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Sample records for photon beam therapy

  1. A review on photoneutrons characteristics in radiation therapy with high-energy photon beams.

    PubMed

    Naseri, Alireza; Mesbahi, Asghar

    2010-09-22

    In radiation therapy with high-energy photon beams (E > 10 MeV) neutrons are generated mainly in linacs head thorough (γ,n) interactions of photons with nuclei of high atomic number materials that constitute the linac head and the beam collimation system. These neutrons affect the shielding requirements in radiation therapy rooms and also increase the out-of-field radiation dose of patients undergoing radiation therapy with high-energy photon beams. In the current review, the authors describe the factors influencing the neutron production for different medical linacs based on the performed measurements and Monte Carlo studies in the literature.

  2. Optimization of photon beam energies in gold nanoparticle enhanced arc radiation therapy using Monte Carlo methods.

    PubMed

    Koger, B; Kirkby, C

    2016-12-02

    As a recent area of development in radiation therapy, gold nanoparticle (GNP) enhanced radiation therapy has shown potential to increase tumour dose while maintaining acceptable levels of healthy tissue toxicity. In this study, the effect of varying photon beam energy in GNP enhanced arc radiation therapy (GEART) is quantified through the introduction of a dose scoring metric, and GEART is compared to a conventional radiotherapy treatment. The PENELOPE Monte Carlo code was used to model several simple phantoms consisting of a spherical tumour containing GNPs (concentration: 15 mg Au g(-1) tumour, 0.8 mg Au g(-1) normal tissue) in a cylinder of tissue. Several monoenergetic photon beams, with energies ranging from 20 keV to 6 MeV, as well as 100, 200, and 300 kVp spectral beams, were used to irradiate the tumour in a 360° arc treatment. A dose metric was then used to compare tumour and tissue doses from GEART treatments to a similar treatment from a 6 MV spectrum. This was also performed on a simulated brain tumour using patient computed tomography data. GEART treatments showed potential over the 6 MV treatment for many of the simulated geometries, delivering up to 88% higher mean dose to the tumour for a constant tissue dose, with the effect greatest near a source energy of 50 keV. This effect is also seen with the inclusion of bone in a brain treatment, with a 14% increase in mean tumour dose over 6 MV, while still maintaining acceptable levels of dose to the bone and brain.

  3. Optimization of photon beam energies in gold nanoparticle enhanced arc radiation therapy using Monte Carlo methods

    NASA Astrophysics Data System (ADS)

    Koger, B.; Kirkby, C.

    2016-12-01

    As a recent area of development in radiation therapy, gold nanoparticle (GNP) enhanced radiation therapy has shown potential to increase tumour dose while maintaining acceptable levels of healthy tissue toxicity. In this study, the effect of varying photon beam energy in GNP enhanced arc radiation therapy (GEART) is quantified through the introduction of a dose scoring metric, and GEART is compared to a conventional radiotherapy treatment. The PENELOPE Monte Carlo code was used to model several simple phantoms consisting of a spherical tumour containing GNPs (concentration: 15 mg Au g-1 tumour, 0.8 mg Au g-1 normal tissue) in a cylinder of tissue. Several monoenergetic photon beams, with energies ranging from 20 keV to 6 MeV, as well as 100, 200, and 300 kVp spectral beams, were used to irradiate the tumour in a 360° arc treatment. A dose metric was then used to compare tumour and tissue doses from GEART treatments to a similar treatment from a 6 MV spectrum. This was also performed on a simulated brain tumour using patient computed tomography data. GEART treatments showed potential over the 6 MV treatment for many of the simulated geometries, delivering up to 88% higher mean dose to the tumour for a constant tissue dose, with the effect greatest near a source energy of 50 keV. This effect is also seen with the inclusion of bone in a brain treatment, with a 14% increase in mean tumour dose over 6 MV, while still maintaining acceptable levels of dose to the bone and brain.

  4. Radiation dose enhancement in skin therapy with nanoparticle addition: A Monte Carlo study on kilovoltage photon and megavoltage electron beams

    PubMed Central

    Zheng, Xiao J; Chow, James C L

    2017-01-01

    AIM To investigated the dose enhancement due to the incorporation of nanoparticles in skin therapy using the kilovoltage (kV) photon and megavoltage (MV) electron beams. Monte Carlo simulations were used to predict the dose enhancement when different types and concentrations of nanoparticles were added to skin target layers of varying thickness. METHODS Clinical kV photon beams (105 and 220 kVp) and MV electron beams (4 and 6 MeV), produced by a Gulmay D3225 orthovoltage unit and a Varian 21 EX linear accelerator, were simulated using the EGSnrc Monte Carlo code. Doses at skin target layers with thicknesses ranging from 0.5 to 5 mm for the photon beams and 0.5 to 10 mm for the electron beams were determined. The skin target layer was added with the Au, Pt, I, Ag and Fe2O3 nanoparticles with concentrations ranging from 3 to 40 mg/mL. The dose enhancement ratio (DER), defined as the dose at the target layer with nanoparticle addition divided by the dose at the layer without nanoparticle addition, was calculated for each nanoparticle type, nanoparticle concentration and target layer thickness. RESULTS It was found that among all nanoparticles, Au had the highest DER (5.2-6.3) when irradiated with kV photon beams. Dependence of the DER on the target layer thickness was not significant for the 220 kVp photon beam but it was for 105 kVp beam for Au nanoparticle concentrations higher than 18 mg/mL. For other nanoparticles, the DER was dependent on the atomic number of the nanoparticle and energy spectrum of the photon beams. All nanoparticles showed an increase of DER with nanoparticle concentration during the photon beam irradiations regardless of thickness. For electron beams, the Au nanoparticles were found to have the highest DER (1.01-1.08) when the beam energy was equal to 4 MeV, but this was drastically lower than the DER values found using photon beams. The DER was also found affected by the depth of maximum dose of the electron beam and target thickness. For

  5. Evaluation of a 50-MV Photon Therapy Beam from a Racetrack Microtron Using MCNP4B Monte Carlo Code

    NASA Astrophysics Data System (ADS)

    Gudowska, I.; Sorcini, B.; Svensson, R.

    High energy photon therapy beam from the 50 MV racetrack microtron has been evaluated using the Monte Carlo code MCNP4B. The spatial and energy distribution of photons, radial and depth dose distributions in the phantom are calculated for the stationary and scanned photon beams from different targets. The calculated dose distributions are compared to the experimental data using a silicon diode detector. Measured and calculated depth-dose distributions are in fairly good agreement, within 2-3% for the positions in the range 2-30 cm in the phantom, whereas the larger discrepancies up to 10% are observed in the dose build-up region. For the stationary beams the differences in the calculated and measured radial dose distributions axe about 2-10%.

  6. The use of intensity-modulated radiation therapy photon beams for improving the dose uniformity of electron beams shaped with MLC

    SciTech Connect

    Mosalaei, Homeira; Karnas, Scott; Shah, Sheel; Van Doodewaard, Sharon; Foster, Tim; Chen, Jeff

    2012-04-01

    Electrons are ideal for treating shallow tumors and sparing adjacent normal tissue. Conventionally, electron beams are collimated by cut-outs that are time-consuming to make and difficult to adapt to tumor shape throughout the course of treatment. We propose that electron cut-outs can be replaced using photon multileaf collimator (MLC). Two major problems of this approach are that the scattering of electrons causes penumbra widening because of a large air gap, and available commercial treatment planning systems (TPSs) do not support MLC-collimated electron beams. In this study, these difficulties were overcome by (1) modeling electron beams collimated by photon MLC for a commercial TPS, and (2) developing a technique to reduce electron beam penumbra by adding low-energy intensity-modulated radiation therapy (IMRT) photons (4 MV). We used blocks to simulate MLC shielding in the TPS. Inverse planning was used to optimize boost photon beams. This technique was applied to a parotid and a central nervous system (CNS) clinical case. Combined photon and electron plans were compared with conventional plans and verified using ion chamber, film, and a 2D diode array. Our studies showed that the beam penumbra for mixed beams with 90 cm source to surface distance (SSD) is comparable with electron applicators and cut-outs at 100 cm SSD. Our mixed-beam technique yielded more uniform dose to the planning target volume and lower doses to various organs at risk for both parotid and CNS clinical cases. The plans were verified with measurements, with more than 95% points passing the gamma criteria of 5% in dose difference and 5 mm for distance to agreement. In conclusion, the study has demonstrated the feasibility and potential advantage of using photon MLC to collimate electron beams with boost photon IMRT fields.

  7. Photon beam position monitor

    DOEpatents

    Kuzay, T.M.; Shu, D.

    1995-02-07

    A photon beam position monitor is disclosed for use in the front end of a beamline of a high heat flux and high energy photon source such as a synchrotron radiation storage ring detects and measures the position and, when a pair of such monitors are used in tandem, the slope of a photon beam emanating from an insertion device such as a wiggler or an undulator inserted in the straight sections of the ring. The photon beam position monitor includes a plurality of spaced blades for precisely locating the photon beam, with each blade comprised of chemical vapor deposition (CVD) diamond with an outer metal coating of a photon sensitive metal such as tungsten, molybdenum, etc., which combination emits electrons when a high energy photon beam is incident upon the blade. Two such monitors are contemplated for use in the front end of the beamline, with the two monitors having vertically and horizontally offset detector blades to avoid blade ''shadowing''. Provision is made for aligning the detector blades with the photon beam and limiting detector blade temperature during operation. 18 figs.

  8. Photon beam position monitor

    DOEpatents

    Kuzay, Tuncer M.; Shu, Deming

    1995-01-01

    A photon beam position monitor for use in the front end of a beamline of a high heat flux and high energy photon source such as a synchrotron radiation storage ring detects and measures the position and, when a pair of such monitors are used in tandem, the slope of a photon beam emanating from an insertion device such as a wiggler or an undulator inserted in the straight sections of the ring. The photon beam position monitor includes a plurality of spaced blades for precisely locating the photon beam, with each blade comprised of chemical vapor deposition (CVD) diamond with an outer metal coating of a photon sensitive metal such as tungsten, molybdenum, etc., which combination emits electrons when a high energy photon beam is incident upon the blade. Two such monitors are contemplated for use in the front end of the beamline, with the two monitors having vertically and horizontally offset detector blades to avoid blade "shadowing". Provision is made for aligning the detector blades with the photon beam and limiting detector blade temperature during operation.

  9. Monitor unit calculations for external photon and electron beams: Report of the AAPM Therapy Physics Committee Task Group No. 71

    SciTech Connect

    Gibbons, John P.; Antolak, John A.; Followill, David S.; Huq, M. Saiful; Klein, Eric E.; Lam, Kwok L.; Palta, Jatinder R.; Roback, Donald M.; Reid, Mark; Khan, Faiz M.

    2014-03-15

    A protocol is presented for the calculation of monitor units (MU) for photon and electron beams, delivered with and without beam modifiers, for constant source-surface distance (SSD) and source-axis distance (SAD) setups. This protocol was written by Task Group 71 of the Therapy Physics Committee of the American Association of Physicists in Medicine (AAPM) and has been formally approved by the AAPM for clinical use. The protocol defines the nomenclature for the dosimetric quantities used in these calculations, along with instructions for their determination and measurement. Calculations are made using the dose per MU under normalization conditions, D{sub 0}{sup ′}, that is determined for each user's photon and electron beams. For electron beams, the depth of normalization is taken to be the depth of maximum dose along the central axis for the same field incident on a water phantom at the same SSD, where D{sub 0}{sup ′} = 1 cGy/MU. For photon beams, this task group recommends that a normalization depth of 10 cm be selected, where an energy-dependent D{sub 0}{sup ′} ≤ 1 cGy/MU is required. This recommendation differs from the more common approach of a normalization depth of d{sub m}, with D{sub 0}{sup ′} = 1 cGy/MU, although both systems are acceptable within the current protocol. For photon beams, the formalism includes the use of blocked fields, physical or dynamic wedges, and (static) multileaf collimation. No formalism is provided for intensity modulated radiation therapy calculations, although some general considerations and a review of current calculation techniques are included. For electron beams, the formalism provides for calculations at the standard and extended SSDs using either an effective SSD or an air-gap correction factor. Example tables and problems are included to illustrate the basic concepts within the presented formalism.

  10. Monitor unit calculations for external photon and electron beams: Report of the AAPM Therapy Physics Committee Task Group No. 71.

    PubMed

    Gibbons, John P; Antolak, John A; Followill, David S; Huq, M Saiful; Klein, Eric E; Lam, Kwok L; Palta, Jatinder R; Roback, Donald M; Reid, Mark; Khan, Faiz M

    2014-03-01

    A protocol is presented for the calculation of monitor units (MU) for photon and electron beams, delivered with and without beam modifiers, for constant source-surface distance (SSD) and source-axis distance (SAD) setups. This protocol was written by Task Group 71 of the Therapy Physics Committee of the American Association of Physicists in Medicine (AAPM) and has been formally approved by the AAPM for clinical use. The protocol defines the nomenclature for the dosimetric quantities used in these calculations, along with instructions for their determination and measurement. Calculations are made using the dose per MU under normalization conditions, D'0, that is determined for each user's photon and electron beams. For electron beams, the depth of normalization is taken to be the depth of maximum dose along the central axis for the same field incident on a water phantom at the same SSD, where D'0 = 1 cGy/MU. For photon beams, this task group recommends that a normalization depth of 10 cm be selected, where an energy-dependent D'0 ≤ 1 cGy/MU is required. This recommendation differs from the more common approach of a normalization depth of dm, with D'0 = 1 cGy/MU, although both systems are acceptable within the current protocol. For photon beams, the formalism includes the use of blocked fields, physical or dynamic wedges, and (static) multileaf collimation. No formalism is provided for intensity modulated radiation therapy calculations, although some general considerations and a review of current calculation techniques are included. For electron beams, the formalism provides for calculations at the standard and extended SSDs using either an effective SSD or an air-gap correction factor. Example tables and problems are included to illustrate the basic concepts within the presented formalism.

  11. Introduction to Ion Beam Therapy

    SciTech Connect

    Martisikova, Maria

    2010-01-05

    Presently, ion beam therapy reaches an increasing interest within the field of radiation therapy, which is caused by the promising clinical results obtained in the last decades. Ion beams enable higher dose conformation to the tumor and increased sparing of the surrounding tissue in comparison to the standard therapy using high energy photons. Heavy ions, like carbon, offer in addition increased biological effectiveness, which makes them suitable for treatment of radioresistant tumors. This contribution gives an overview over the physical and biological properties of ion beams. Common fundamental principles of ion beam therapy are summarized and differences between standard therapy with high energy photons, proton and carbon ion therapy are discussed. The technologies used for the beam production and delivery are introduced, with emphasis to the differences between passive and active beam delivery systems. The last part concentrates on the quality assurance in ion therapy. Specialties of dosimetry in medical ion beams are discussed.

  12. Cerenkov light spectrum in an optical fiber exposed to a photon or electron radiation therapy beam

    SciTech Connect

    Lambert, Jamil; Yin Yongbai; McKenzie, David R.; Law, Sue; Suchowerska, Natalka

    2009-06-20

    A Cerenkov signal is generated when energetic charged particles enter the core of an optical fiber. The Cerenkov intensity can be large enough to interfere with signals transmitted through the fiber. We determine the spectrum of the Cerenkov background signal generated in a poly(methyl methacrylate) optical fiber exposed to photon and electron therapeutic beams from a linear accelerator. This spectral measurement is relevant to discrimination of the signal from the background, as in scintillation dosimetry using optical fiber readouts. We find that the spectrum is approximated by the theoretical curve after correction for the wavelength dependent attenuation of the fiber. The spectrum does not depend significantly on the angle between the radiation beam and the axis of the fiber optic but is dependent on the depth in water at which the fiber is exposed to the beam.

  13. Clinical implementation of the Peregrine Monte Carlo dose calculations system for photon beam therapy

    SciTech Connect

    Albright, N; Bergstrom, P M; Daly, T P; Descalle, M; Garrett, D; House, R K; Knapp, D K; May, S; Patterson, R W; Siantar, C L; Verhey, L; Walling, R S; Welczorek, D

    1999-07-01

    PEREGRINE is a 3D Monte Carlo dose calculation system designed to serve as a dose calculation engine for clinical radiation therapy treatment planning systems. Taking advantage of recent advances in low-cost computer hardware, modern multiprocessor architectures and optimized Monte Carlo transport algorithms, PEREGRINE performs mm-resolution Monte Carlo calculations in times that are reasonable for clinical use. PEREGRINE has been developed to simulate radiation therapy for several source types, including photons, electrons, neutrons and protons, for both teletherapy and brachytherapy. However the work described in this paper is limited to linear accelerator-based megavoltage photon therapy. Here we assess the accuracy, reliability, and added value of 3D Monte Carlo transport for photon therapy treatment planning. Comparisons with clinical measurements in homogeneous and heterogeneous phantoms demonstrate PEREGRINE's accuracy. Studies with variable tissue composition demonstrate the importance of material assignment on the overall dose distribution. Detailed analysis of Monte Carlo results provides new information for radiation research by expanding the set of observables.

  14. Bone and mucosal dosimetry in skin radiation therapy: a Monte Carlo study using kilovoltage photon and megavoltage electron beams

    NASA Astrophysics Data System (ADS)

    Chow, James C. L.; Jiang, Runqing

    2012-06-01

    This study examines variations of bone and mucosal doses with variable soft tissue and bone thicknesses, mimicking the oral or nasal cavity in skin radiation therapy. Monte Carlo simulations (EGSnrc-based codes) using the clinical kilovoltage (kVp) photon and megavoltage (MeV) electron beams, and the pencil-beam algorithm (Pinnacle3 treatment planning system) using the MeV electron beams were performed in dose calculations. Phase-space files for the 105 and 220 kVp beams (Gulmay D3225 x-ray machine), and the 4 and 6 MeV electron beams (Varian 21 EX linear accelerator) with a field size of 5 cm diameter were generated using the BEAMnrc code, and verified using measurements. Inhomogeneous phantoms containing uniform water, bone and air layers were irradiated by the kVp photon and MeV electron beams. Relative depth, bone and mucosal doses were calculated for the uniform water and bone layers which were varied in thickness in the ranges of 0.5-2 cm and 0.2-1 cm. A uniform water layer of bolus with thickness equal to the depth of maximum dose (dmax) of the electron beams (0.7 cm for 4 MeV and 1.5 cm for 6 MeV) was added on top of the phantom to ensure that the maximum dose was at the phantom surface. From our Monte Carlo results, the 4 and 6 MeV electron beams were found to produce insignificant bone and mucosal dose (<1%), when the uniform water layer at the phantom surface was thicker than 1.5 cm. When considering the 0.5 cm thin uniform water and bone layers, the 4 MeV electron beam deposited less bone and mucosal dose than the 6 MeV beam. Moreover, it was found that the 105 kVp beam produced more than twice the dose to bone than the 220 kVp beam when the uniform water thickness at the phantom surface was small (0.5 cm). However, the difference in bone dose enhancement between the 105 and 220 kVp beams became smaller when the thicknesses of the uniform water and bone layers in the phantom increased. Dose in the second bone layer interfacing with air was found to be

  15. Photon Collider Physics with Real Photon Beams

    SciTech Connect

    Gronberg, J; Asztalos, S

    2005-11-03

    Photon-photon interactions have been an important probe into fundamental particle physics. Until recently, the only way to produce photon-photon collisions was parasitically in the collision of charged particles. Recent advances in short-pulse laser technology have made it possible to consider producing high intensity, tightly focused beams of real photons through Compton scattering. A linear e{sup +}e{sup -} collider could thus be transformed into a photon-photon collider with the addition of high power lasers. In this paper they show that it is possible to make a competitive photon-photon collider experiment using the currently mothballed Stanford Linear Collider. This would produce photon-photon collisions in the GeV energy range which would allow the discovery and study of exotic heavy mesons with spin states of zero and two.

  16. Dependences of mucosal dose on photon beams in head-and-neck intensity-modulated radiation therapy: a Monte Carlo study

    SciTech Connect

    Chow, James C.L.; Owrangi, Amir M.

    2012-07-01

    Dependences of mucosal dose in the oral or nasal cavity on the beam energy, beam angle, multibeam configuration, and mucosal thickness were studied for small photon fields using Monte Carlo simulations (EGSnrc-based code), which were validated by measurements. Cylindrical mucosa phantoms (mucosal thickness = 1, 2, and 3 mm) with and without the bone and air inhomogeneities were irradiated by the 6- and 18-MV photon beams (field size = 1 Multiplication-Sign 1 cm{sup 2}) with gantry angles equal to 0 Degree-Sign , 90 Degree-Sign , and 180 Degree-Sign , and multibeam configurations using 2, 4, and 8 photon beams in different orientations around the phantom. Doses along the central beam axis in the mucosal tissue were calculated. The mucosal surface doses were found to decrease slightly (1% for the 6-MV photon beam and 3% for the 18-MV beam) with an increase of mucosal thickness from 1-3 mm, when the beam angle is 0 Degree-Sign . The variation of mucosal surface dose with its thickness became insignificant when the beam angle was changed to 180 Degree-Sign , but the dose at the bone-mucosa interface was found to increase (28% for the 6-MV photon beam and 20% for the 18-MV beam) with the mucosal thickness. For different multibeam configurations, the dependence of mucosal dose on its thickness became insignificant when the number of photon beams around the mucosal tissue was increased. The mucosal dose with bone was varied with the beam energy, beam angle, multibeam configuration and mucosal thickness for a small segmental photon field. These dosimetric variations are important to consider improving the treatment strategy, so the mucosal complications in head-and-neck intensity-modulated radiation therapy can be minimized.

  17. Radiation Therapy of Large Intact Breasts Using a Beam Spoiler or Photons with Mixed Energies

    SciTech Connect

    Lief, Eugene P. Hunt, Margie A.; Hong, Linda X.; Amols, Howard I.

    2007-01-01

    Radiation treatment of large intact breasts with separations of more than 24 cm is typically performed using x-rays with energies of 10 MV and higher, to eliminate high-dose regions in tissue. The disadvantage of the higher energy beams is the reduced dose to superficial tissue in the buildup region. We evaluated 2 methods of avoiding this underdosage: (1) a beam spoiler: 1.7-cm-thick Lucite plate positioned in the blocking tray 35 cm from the isocenter, with 15-MV x-rays; and (2) combining 6- and 15-MV x-rays through the same portal. For the beam with the spoiler, we measured the dose distribution for normal and oblique incidence using a film and ion chamber in polystyrene, as well as a scanning diode in a water tank. In the mixed-energy approach, we calculated the dose distributions in the buildup region for different proportions of 6- and 15-MV beams. The dose enhancement due to the beam spoiler exhibited significant dependence upon the source-to-skin distance (SSD), field size, and the angle of incidence. In the center of a 20 x 20-cm{sup 2} field at 90-cm SSD, the beam spoiler raises the dose at 5-mm depth from 77% to 87% of the prescription, while maintaining the skin dose below 57%. Comparison of calculated dose with measurements suggested a practical way of treatment planning with the spoiler-usage of 2-mm 'beam' bolus-a special option offered by in-house treatment planning system. A second method of increasing buildup doses is to mix 6- and 15-MV beams. For example, in the case of a parallel-opposed irradiation of a 27-cm-thick phantom, dose to D{sub max} for each energy, with respect to midplane, is 114% for pure 6-, 107% for 15-MV beam with the spoiler, and 108% for a 3:1 mixture of 15- and 6-MV beams. Both methods are practical for radiation therapy of large intact breasts.

  18. Radiation therapy of large intact breasts using a beam spoiler or photons with mixed energies.

    PubMed

    Lief, Eugene P; Hunt, Margie A; Hong, Linda X; Amols, Howard I

    2007-01-01

    Radiation treatment of large intact breasts with separations of more than 24 cm is typically performed using x-rays with energies of 10 MV and higher, to eliminate high-dose regions in tissue. The disadvantage of the higher energy beams is the reduced dose to superficial tissue in the buildup region. We evaluated 2 methods of avoiding this underdosage: (1) a beam spoiler: 1.7-cm-thick Lucite plate positioned in the blocking tray 35 cm from the isocenter, with 15-MV x-rays; and (2) combining 6- and 15-MV x-rays through the same portal. For the beam with the spoiler, we measured the dose distribution for normal and oblique incidence using a film and ion chamber in polystyrene, as well as a scanning diode in a water tank. In the mixed-energy approach, we calculated the dose distributions in the buildup region for different proportions of 6- and 15-MV beams. The dose enhancement due to the beam spoiler exhibited significant dependence upon the source-to-skin distance (SSD), field size, and the angle of incidence. In the center of a 20 x 20-cm(2) field at 90-cm SSD, the beam spoiler raises the dose at 5-mm depth from 77% to 87% of the prescription, while maintaining the skin dose below 57%. Comparison of calculated dose with measurements suggested a practical way of treatment planning with the spoiler--usage of 2-mm "beam" bolus--a special option offered by in-house treatment planning system. A second method of increasing buildup doses is to mix 6- and 15-MV beams. For example, in the case of a parallel-opposed irradiation of a 27-cm-thick phantom, dose to D(max) for each energy, with respect to midplane, is 114% for pure 6-, 107% for 15-MV beam with the spoiler, and 108% for a 3:1 mixture of 15- and 6-MV beams. Both methods are practical for radiation therapy of large intact breasts.

  19. Radiation Therapy Photon Beams Dose Conformation According to Dose Distribution Around Intracavitary-Applied Brachytherapy Sources

    SciTech Connect

    Jurkovic, Slaven Zauhar, Gordana; Faj, Dario; Radojcic, Deni Smilovic; Svabic, Manda

    2010-04-01

    Intracavitary application of brachytherapy sources followed by external beam radiation is essential for the local treatment of carcinoma of the cervix. Due to very high doses to the central portion of the target volume delivered by brachytherapy sources, this part of the target volume must be shielded while being irradiated by photon beams. Several shielding techniques are available, from rectangular block and standard cervix wedge to more precise, customized step wedge filters. Because the calculation of a step wedge filter's shape was usually based on effective attenuation coefficient, an approach that accounts, in a more precise way, for the scattered radiation, is suggested. The method was verified under simulated clinical conditions using film dosimetry. Measured data for various compensators were compared to the numerically determined sum of the dose distribution around brachytherapy sources and one of compensated beam. Improvements in total dose distribution are demonstrated, using our method. Agreement between calculation and measurements were within 3%. Sensitivity of the method on sources displacement during treatment has also been investigated.

  20. Monitor unit calculations for external photon and electron beams: Report of the AAPM Therapy Physics Committee Task Group No. 71

    PubMed Central

    Gibbons, John P.; Antolak, John A.; Followill, David S.; Huq, M. Saiful; Klein, Eric E.; Lam, Kwok L.; Palta, Jatinder R.; Roback, Donald M.; Reid, Mark; Khan, Faiz M.

    2014-01-01

    A protocol is presented for the calculation of monitor units (MU) for photon and electron beams, delivered with and without beam modifiers, for constant source-surface distance (SSD) and source-axis distance (SAD) setups. This protocol was written by Task Group 71 of the Therapy Physics Committee of the American Association of Physicists in Medicine (AAPM) and has been formally approved by the AAPM for clinical use. The protocol defines the nomenclature for the dosimetric quantities used in these calculations, along with instructions for their determination and measurement. Calculations are made using the dose per MU under normalization conditions, \\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{upgreek} \\usepackage{mathrsfs} \\setlength{\\oddsidemargin}{-69pt} \\begin{document} }{}$D_0^\\prime $\\end{document}D0′, that is determined for each user's photon and electron beams. For electron beams, the depth of normalization is taken to be the depth of maximum dose along the central axis for the same field incident on a water phantom at the same SSD, where \\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{upgreek} \\usepackage{mathrsfs} \\setlength{\\oddsidemargin}{-69pt} \\begin{document} }{}$D_0^\\prime $\\end{document}D0′ = 1 cGy/MU. For photon beams, this task group recommends that a normalization depth of 10 cm be selected, where an energy-dependent \\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{upgreek} \\usepackage{mathrsfs} \\setlength{\\oddsidemargin}{-69pt} \\begin{document} }{}$D_0^\\prime $\\end{document}D0′ ≤ 1 cGy/MU is required. This recommendation differs from the more common approach of a normalization depth of dm, with

  1. Secondary radiation measurements for particle therapy applications: prompt photons produced by (4)He, (12)C and (16)O ion beams in a PMMA target.

    PubMed

    Mattei, I; Bini, F; Collamati, F; De Lucia, E; Frallicciardi, P M; Iarocci, E; Mancini-Terracciano, C; Marafini, M; Muraro, S; Paramatti, R; Patera, V; Piersanti, L; Pinci, D; Rucinski, A; Russomando, A; Sarti, A; Sciubba, A; Solfaroli Camillocci, E; Toppi, M; Traini, G; Voena, C; Battistoni, G

    2017-02-21

    Charged particle beams are used in particle therapy (PT) to treat oncological patients due to their selective dose deposition in tissues with respect to the photons and electrons used in conventional radiotherapy. Heavy (Z  >  1) PT beams can additionally be exploited for their high biological effectiveness in killing cancer cells. Nowadays, protons and carbon ions are used in PT clinical routines. Recently, interest in the potential application of helium and oxygen beams has been growing. With respect to protons, such beams are characterized by their reduced multiple scattering inside the body, increased linear energy transfer, relative biological effectiveness and oxygen enhancement ratio. The precision of PT demands online dose monitoring techniques, crucial to improving the quality assurance of any treatment: possible patient mis-positioning and biological tissue changes with respect to the planning CT scan could negatively affect the outcome of the therapy. The beam range confined in the irradiated target can be monitored thanks to the neutral or charged secondary radiation emitted by the interactions of hadron beams with matter. Among these secondary products, prompt photons are produced by nuclear de-excitation processes, and at present, different dose monitoring and beam range verification techniques based on prompt-γ detection are being proposed. It is hence of importance to perform γ yield measurement in therapeutic-like conditions. In this paper we report on the yields of prompt photons produced by the interaction of helium, carbon and oxygen ion beams with a poly-methyl methacrylate (PMMA) beam stopping target. The measurements were performed at the Heidelberg Ion-Beam Therapy Center (HIT) with beams of different energies. An LYSO scintillator, placed at [Formula: see text] and [Formula: see text] with respect to the beam direction, was used as the photon detector. The obtained γ yields for the carbon ion beams are compared with results from

  2. Secondary radiation measurements for particle therapy applications: prompt photons produced by 4He, 12C and 16O ion beams in a PMMA target

    NASA Astrophysics Data System (ADS)

    Mattei, I.; Bini, F.; Collamati, F.; De Lucia, E.; Frallicciardi, P. M.; Iarocci, E.; Mancini-Terracciano, C.; Marafini, M.; Muraro, S.; Paramatti, R.; Patera, V.; Piersanti, L.; Pinci, D.; Rucinski, A.; Russomando, A.; Sarti, A.; Sciubba, A.; Solfaroli Camillocci, E.; Toppi, M.; Traini, G.; Voena, C.; Battistoni, G.

    2017-02-01

    Charged particle beams are used in particle therapy (PT) to treat oncological patients due to their selective dose deposition in tissues with respect to the photons and electrons used in conventional radiotherapy. Heavy (Z  >  1) PT beams can additionally be exploited for their high biological effectiveness in killing cancer cells. Nowadays, protons and carbon ions are used in PT clinical routines. Recently, interest in the potential application of helium and oxygen beams has been growing. With respect to protons, such beams are characterized by their reduced multiple scattering inside the body, increased linear energy transfer, relative biological effectiveness and oxygen enhancement ratio. The precision of PT demands online dose monitoring techniques, crucial to improving the quality assurance of any treatment: possible patient mis-positioning and biological tissue changes with respect to the planning CT scan could negatively affect the outcome of the therapy. The beam range confined in the irradiated target can be monitored thanks to the neutral or charged secondary radiation emitted by the interactions of hadron beams with matter. Among these secondary products, prompt photons are produced by nuclear de-excitation processes, and at present, different dose monitoring and beam range verification techniques based on prompt-γ detection are being proposed. It is hence of importance to perform γ yield measurement in therapeutic-like conditions. In this paper we report on the yields of prompt photons produced by the interaction of helium, carbon and oxygen ion beams with a poly-methyl methacrylate (PMMA) beam stopping target. The measurements were performed at the Heidelberg Ion-Beam Therapy Center (HIT) with beams of different energies. An LYSO scintillator, placed at {{60}\\circ} and {{90}\\circ} with respect to the beam direction, was used as the photon detector. The obtained γ yields for the carbon ion beams are compared with results from the literature

  3. A comparative dosimetric study on tangential photon beams, intensity-modulated radiation therapy (IMRT) and modulated electron radiotherapy (MERT) for breast cancer treatment

    NASA Astrophysics Data System (ADS)

    Ma, C.-M.; Ding, M.; Li, J. S.; Lee, M. C.; Pawlicki, T.; Deng, J.

    2003-04-01

    Recently, energy- and intensity-modulated electron radiotherapy (MERT) has garnered a growing interest for the treatment of superficial targets. In this work, we carried out a comparative dosimetry study to evaluate MERT, photon beam intensity-modulated radiation therapy (IMRT) and conventional tangential photon beams for the treatment of breast cancer. A Monte Carlo based treatment planning system has been investigated, which consists of a set of software tools to perform accurate dose calculation, treatment optimization, leaf sequencing and plan analysis. We have compared breast treatment plans generated using this home-grown treatment optimization and dose calculation software for these treatment techniques. The MERT plans were planned with up to two gantry angles and four nominal energies (6, 9, 12 and 16 MeV). The tangential photon treatment plans were planned with 6 MV wedged photon beams. The IMRT plans were planned using both multiple-gantry 6 MV photon beams or two 6 MV tangential beams. Our results show that tangential IMRT can reduce the dose to the lung, heart and contralateral breast compared to conventional tangential wedged beams (up to 50% reduction in high dose volume or 5 Gy in the maximum dose). MERT can reduce the maximum dose to the lung by up to 20 Gy and to the heart by up to 35 Gy compared to conventional tangential wedged beams. Multiple beam angle IMRT can significantly reduce the maximum dose to the lung and heart (up to 20 Gy) but it induces low and medium doses to a large volume of normal tissues including lung, heart and contralateral breast. It is concluded that MERT has superior capabilities to achieve dose conformity both laterally and in the depth direction, which will be well suited for treating superficial targets such as breast cancer.

  4. High flux photon beam monitor

    SciTech Connect

    Mortazavi, P.; Woodle, M.; Rarback, H.; Shu, D.; Howells, M.

    1985-01-01

    We have designed two photon beam position monitors for use on our x-ray storage ring beam lines. In both designs, a pair of tungsten blades, separated by a pre-determined gap, intercepts a small fraction of the incoming beam. Due to photoemission, an electrical signal is generated which is proportional to the amount of beam intercepted. The thermal load deposited in the blade is transferred by a heat pipe to a heat exchanger outside the vacuum chamber. A prototype monitor with gap adjustment capability was fabricated and tested at a uv beam line. The results show that the generated electrical signal is a good measurement of the photon beam position. In the following sections, design features and test results are discussed.

  5. The Use of Photon Beams of a Flattening Filter-free Linear Accelerator for Hypofractionated Volumetric Modulated Arc Therapy in Localized Prostate Cancer

    SciTech Connect

    Zwahlen, Daniel R.; Lang, Stephanie; Hrbacek, Jan; Glanzmann, Christoph; Kloeck, Stephan; Najafi, Yousef; Streller, Tino; Studer, Gabriela; Zaugg, Kathrin; Luetolf, Urs M.

    2012-08-01

    Purpose: To evaluate the potential usage of flattening filter-free (FFF) photon beams in the treatment of prostate cancer. Methods and Materials: Volumetric-modulated arc therapy (VMAT) treatment planning was performed for 7 patients using TrueBeam{sup Registered-Sign} linear accelerator and photon beams with (X6, X10) and without (X6FFF, X10FFF) flattening filter. Prescribed dose was 19 Multiplication-Sign 3 Gy = 57 Gy. One or two 360 Degree-Sign arcs with dose rate of 600 MU/min for flattened beams, and 1,200 MU/min for FFF beams were used. Results: No difference was detected between the four beams in PTV coverage, conformity, and homogeneity. Mean body dose and body volume receiving 50% of the prescribed dose decreased with increasing mean energy (r{sup 2} = 0.8275, p < 0.01). X6FFF delivered 3.6% more dose compared with the X6 (p < 0.01). X10FFF delivered 3.0% (p < 0.01), and the X10 5.8% (p < 0.01) less mean body dose compared with X6. There was a significant increase in the mean dose to the rectum for the X10 compared with X6 (2.6%, p < 0.01). Mean dose to the bladder increased by 1.3% for X6FFF and decreased by 2.3% for X10FFF. Using a single arc and FFF, treatment time was reduced by 35% (2 SD = 10%). Conclusion: FFF beams resulted in dose distributions similar to flattened beams. X10FFF beam provided the best solution, sparing rectum and bladder and minimizing whole-body dose. FFF beams lead to a time efficient treatment delivery, particularly when combined with hypofractionated VMAT.

  6. Monte Carlo simulation of photon emission below a few hundred kiloelectronvolts for beam monitoring in carbon ion therapy

    NASA Astrophysics Data System (ADS)

    Yamaguchi, Mitsutaka; Nagao, Yuto; Satoh, Takahiro; Sugai, Hiroyuki; Sakai, Makoto; Arakawa, Kazuo; Kawachi, Naoki

    2017-01-01

    The purpose of this study is to determine whether the main component of the low-energy (63-68 keV) particles emitted perpendicularly to the 12C beam from the 12C-irradiated region in a water phantom is secondary electron bremsstrahlung (SEB). Monte Carlo simulations of a 12C-beam (290 MeV/u) irradiated on a water phantom were performed. A detector was placed beside the water phantom with a lead collimator between the phantom and the detector. To move the Bragg-peak position, a binary filter was placed in an upper stream of the phantom. The energy distributions of the particles incident on the detector and those deposited in the detector were analyzed. The simulation was also performed with suppressed delta-ray and/or bremsstrahlung generation to identify the SEB components. It was found that the particles incident on the detector were predominantly photons and neutrons. The yields of the photons and energy deposition decreased with the suppression of SEB generation. It is concluded that one of the predominant components of the yields in the regions shallower than the Bragg-peak position is due to SEB generation, and these components become significantly smaller in regions deeper than the Bragg-peak position.

  7. Regenerative photonic therapy: Review

    NASA Astrophysics Data System (ADS)

    Salansky, Natasha; Salansky, Norman

    2012-09-01

    After four decades of research of photobiomodulation phenomena in mammals in vitro and in vivo, a solid foundation is created for the use of photobiomodulation in regenerative medicine. Significant accomplishments are achieved in animal models that demonstrate opportunities for photo-regeneration of injured or pathological tissues: skin, muscles and nerves. However, the use of photobiomodulation in clinical studies leads to controversial results while negative or marginal clinical efficacy is reported along with positive findings. A thor ough analysis of requirements to the optical parameters (dosimetry) for high efficacy in photobimodulation led us to the conclusion that there are several misconceptions in the clinical applications of low level laser therapy (LLLT). We present a novel appr oach of regenerative photonic therapy (RPT) for tissue healing and regeneration that overcomes major drawbacks of LLLT. Encouraging clinical results on RPT efficacy are presented. Requirements for RPT approach and vision for its future development for tissue regeneration is discussed.

  8. Long-term Cosmetic Outcomes and Toxicities of Proton Beam Therapy Compared With Photon-Based 3-Dimensional Conformal Accelerated Partial-Breast Irradiation: A Phase 1 Trial

    SciTech Connect

    Galland-Girodet, Sigolène; Pashtan, Itai; MacDonald, Shannon M.; Ancukiewicz, Marek; Hirsch, Ariel E.; Kachnic, Lisa A.; Specht, Michelle; Gadd, Michele; Smith, Barbara L.; Powell, Simon N.; Recht, Abram; Taghian, Alphonse G.

    2014-11-01

    Purpose: To present long-term outcomes of a prospective feasibility trial using either protons or 3-dimensional conformal photon-based (accelerated partial-breast irradiation [APBI]) techniques. Methods and Materials: From October 2003 to April 2006, 98 evaluable patients with stage I breast cancer were treated with APBI (32 Gy in 8 fractions given twice daily) on a prospective clinical trial: 19 with proton beam therapy (PBT) and 79 with photons or mixed photons/electrons. Median follow-up was 82.5 months (range, 2-104 months). Toxicity and patient satisfaction evaluations were performed at each visit. Results: At 7 years, the physician rating of overall cosmesis was good or excellent for 62% of PBT patients, compared with 94% for photon patients (P=.03). Skin toxicities were more common for the PBT group: telangiectasia, 69% and 16% (P=.0013); pigmentation changes, 54% and 22% (P=.02); and other late skin toxicities, 62% and 18% (P=.029) for PBT and photons, respectively. There were no significant differences between the groups in the incidences of breast pain, edema, fibrosis, fat necrosis, skin desquamation, and rib pain or fracture. Patient-reported cosmetic outcomes at 7 years were good or excellent for 92% and 96% of PBT and photon patients, respectively (P=.95). Overall patient satisfaction was 93% for the entire cohort. The 7-year local failure rate for all patients was 6%, with 3 local recurrences in the PBT group (7-year rate, 11%) and 2 in photon-treated patients (4%) (P=.22). Conclusions: Local failure rates of 3-dimensional APBI and PBT were similar in this study. However, PBT, as delivered in this study, led to higher rates of long-term telangiectasia, skin color changes, and skin toxicities. We recommend the use of multiple fields and treatment of all fields per treatment session or the use of scanning techniques to minimize skin toxicity.

  9. Optimization of combined electron and photon beams for breast cancer

    NASA Astrophysics Data System (ADS)

    Xiong, W.; Li, J.; Chen, L.; Price, R. A.; Freedman, G.; Ding, M.; Qin, L.; Yang, J.; Ma, C.-M.

    2004-05-01

    Recently, intensity-modulated radiation therapy and modulated electron radiotherapy have gathered a growing interest for the treatment of breast and head and neck tumours. In this work, we carried out a study to combine electron and photon beams to achieve differential dose distributions for multiple target volumes simultaneously. A Monte Carlo based treatment planning system was investigated, which consists of a set of software tools to perform accurate dose calculation, treatment optimization, leaf sequencing and plan analysis. We compared breast treatment plans generated using this home-grown optimization and dose calculation software for different treatment techniques. Five different planning techniques have been developed for this study based on a standard photon beam whole breast treatment and an electron beam tumour bed cone down. Technique 1 includes two 6 MV tangential wedged photon beams followed by an anterior boost electron field. Technique 2 includes two 6 MV tangential intensity-modulated photon beams and the same boost electron field. Technique 3 optimizes two intensity-modulated photon beams based on a boost electron field. Technique 4 optimizes two intensity-modulated photon beams and the weight of the boost electron field. Technique 5 combines two intensity-modulated photon beams with an intensity-modulated electron field. Our results show that technique 2 can reduce hot spots both in the breast and the tumour bed compared to technique 1 (dose inhomogeneity is reduced from 34% to 28% for the target). Techniques 3, 4 and 5 can deliver a more homogeneous dose distribution to the target (with dose inhomogeneities for the target of 22%, 20% and 9%, respectively). In many cases techniques 3, 4 and 5 can reduce the dose to the lung and heart. It is concluded that combined photon and electron beam therapy may be advantageous for treating breast cancer compared to conventional treatment techniques using tangential wedged photon beams followed by a boost

  10. A new water-equivalent 2D plastic scintillation detectors array for the dosimetry of megavoltage energy photon beams in radiation therapy

    SciTech Connect

    Guillot, Mathieu; Beaulieu, Luc; Archambault, Louis; Beddar, Sam; Gingras, Luc

    2011-12-15

    Purpose: The objective of this work is to present a new 2D plastic scintillation detectors array (2D-PSDA) designed for the dosimetry of megavoltage (MV) energy photon beams in radiation therapy and to characterize its basic performance. Methods: We developed a 2D detector array consisting of 781 plastic scintillation detectors (PSDs) inserted into a plane of a water-equivalent phantom. The PSDs were distributed on a 26 x 26 cm{sup 2} grid, with an interdetector spacing of 10 mm, except for two perpendicular lines centered on the detection plane, where the spacing was 5 mm. Each PSD was made of a 1 mm diameter by 3 mm long cylindrical polystyrene scintillating fiber coupled to a clear nonscintillating plastic optical fiber. All of the light signals emitted by the PSDs were read simultaneously with an optical system at a rate of one measurement per second. We characterized the performance of the optical system, the angular dependency of the device, and the perturbation of dose distributions caused by the hundreds of PSDs inserted into the phantom. We also evaluated the capacity of the system to monitor complex multileaf collimator (MLC) sequences such as those encountered in step-and-shoot intensity modulated radiation therapy (IMRT) plans. We compared our results with calculations performed by a treatment planning system and with measurements taken with a 2D ionization chamber array and with a radiochromic film. Results: The detector array that we developed allowed us to measure doses with an average precision of better than 1% for cumulated doses equal to or greater than 6.3 cGy. Our results showed that the dose distributions produced by the 6-MV photon beam are not perturbed (within {+-}1.1%) by the presence of the hundreds of PSDs located into the phantom. The results also showed that the variations in the beam incidences have little effect on the dose response of the device. For all incidences tested, the passing rates of the gamma tests between the 2D-PSDA and

  11. Proton Beam Therapy Versus Conformal Photon Radiation Therapy for Childhood Craniopharyngioma: Multi-institutional Analysis of Outcomes, Cyst Dynamics, and Toxicity

    SciTech Connect

    Bishop, Andrew J.; Greenfield, Brad; Mahajan, Anita; Paulino, Arnold C.; Okcu, M. Fatih; Allen, Pamela K.; Chintagumpala, Murali; Kahalley, Lisa S.; McAleer, Mary F.; McGovern, Susan L.; Whitehead, William E.; Grosshans, David R.

    2014-10-01

    Purpose: We compared proton beam therapy (PBT) with intensity modulated radiation therapy (IMRT) for pediatric craniopharyngioma in terms of disease control, cyst dynamics, and toxicity. Methods and Materials: We reviewed records from 52 children treated with PBT (n=21) or IMRT (n=31) at 2 institutions from 1996-2012. Endpoints were overall survival (OS), disease control, cyst dynamics, and toxicity. Results: At 59.6 months' median follow-up (PBT 33 mo vs IMRT 106 mo; P<.001), the 3-year outcomes were 96% for OS, 95% for nodular failure-free survival and 76% for cystic failure-free survival. Neither OS nor disease control differed between treatment groups (OS P=.742; nodular failure-free survival P=.546; cystic failure-free survival P=.994). During therapy, 40% of patients had cyst growth (20% requiring intervention); immediately after therapy, 17 patients (33%) had cyst growth (transient in 14), more commonly in the IMRT group (42% vs 19% PBT; P=.082); and 27% experienced late cyst growth (32% IMRT, 19% PBT; P=.353), with intervention required in 40%. Toxicity did not differ between groups. On multivariate analysis, cyst growth was related to visual and hypothalamic toxicity (P=.009 and .04, respectively). Patients given radiation as salvage therapy (for recurrence) rather than adjuvant therapy had higher rates of visual and endocrine (P=.017 and .024, respectively) dysfunction. Conclusions: Survival and disease-control outcomes were equivalent for PBT and IMRT. Cyst growth is common, unpredictable, and should be followed during and after therapy, because it contributes to late toxicity. Delaying radiation therapy until recurrence may result in worse visual and endocrine function.

  12. Proton beam therapy facility

    SciTech Connect

    Not Available

    1984-10-09

    It is proposed to build a regional outpatient medical clinic at the Fermi National Accelerator Laboratory (Fermilab), Batavia, Illinois, to exploit the unique therapeutic characteristics of high energy proton beams. The Fermilab location for a proton therapy facility (PTF) is being chosen for reasons ranging from lower total construction and operating costs and the availability of sophisticated technical support to a location with good access to patients from the Chicago area and from the entire nation. 9 refs., 4 figs., 26 tabs.

  13. Photon-Electron Interaction and Condense Beams

    SciTech Connect

    Chattopadhyay, S.

    1998-11-01

    We discuss beams of charged particles and radiation from multiple perspectives. These include fundamental acceleration and radiation mechanisms, underlying electron-photon interaction, various classical and quantum phase-space concepts and fluctuational interpretations.

  14. Intensity Modulated Radiotherapy with High Energy Photon and Hadron Beams

    NASA Astrophysics Data System (ADS)

    Oelfke, U.

    2004-07-01

    This short contribution will briefly describe the basic concepts of intensity modulated radiation therapy with high energy photons (IMRT) and charged particle beams (IMPT). Dose delivery and optimization strategies like the `Inverse Planning' approach will be explained for both radiation modalities and their potential advantages are demonstrated for characteristic clinical examples. Finally, future development like image guided radiotherapy (IGRT) and adaptive radiation therapy, based on functional imaging methods, will be introduced.

  15. Clinical evidence of particle beam therapy (proton).

    PubMed

    Ogino, Takashi

    2012-04-01

    Proton beam therapy (PBT) makes it possible to deliver a high concentration of radiation to a tumor using its Bragg peak, and it is simple to utilize as its radiobiological characteristics are identical to those of photon beams. PBT has now been used for half a century, and more than 60,000 patients worldwide are reported to have been treated with proton beams. The most significant change to PBT occurred in the 1990s, when the Loma Linda University Medical Center became the first hospital in the world to operate a medically dedicated proton therapy facility. Following its success, similar medically dedicated facilities have been constructed. Internationally, results have demonstrated the therapeutic superiority of PBT over alternative treatment options for several disease sites. Further advances in PBT are expected from both clinical and technological perspectives.

  16. Efficient beaming of self-collimated light from photonic crystals.

    PubMed

    Park, Jong-Moon; Lee, Sun-Goo; Park, Hae Yong; Kim, Jae-Eun

    2008-12-08

    We propose a novel structure for achieving highly efficient beaming of self-collimated light from two-dimensional photonic crystals. The finite-difference time-domain simulations show that both enhanced transmission and highly directional emission of self-collimated beams from photonic crystals are achieved by using the bending and splitting of self-collimated beams in photonic crystals, and also by introducing an antireflection coating-like photonic crystal collimator to the exit surface of the structure. This structure is potentially important for highly efficient coupling of self-collimated beams from photonic crystals into conventional optical fibers and photonic crystal waveguides.

  17. On beam quality and flatness of radiotherapy megavoltage photon beams

    PubMed Central

    Hossain, Murshed; Rhoades, Jeffrey

    2015-01-01

    Ratio of percentage depth dose (PDD) at two depths, PDD at a depth of 10 cm (PDD10), and beam flatness are monitored regularly for radiotherapy beams for quality assurance. The purpose of this study is to understand the effects of changes in one of these parameters on the other. Is it possible to monitor only the beam flatness and not PDD? The investigation has two components. Naturally occurring i.e., unintended changes in PDD ratio and in-plane flatness for 6 and 10 MV photon beams for one particular Siemens Artiste Linac are monitored for a period of about 4 years. Secondly, deliberate changes in the beam parameters are induced by changing the bending magnet current (BMI). Relationships between various beam parameters for unintended changes as well as deliberate changes are characterized. Long term unintentional changes of PDD ratio are found to have no systematic trend. The flatness in the inplane direction for 6 and 10 MV beams show slow increase of 0.43% and 0.75% respectively in about 4 years while the changes in the PDD ratio show no such trend. Over 10% changes in BMI are required to induce changes in the beam quality indices at 2% level. PDD ratio for the 10 MV beam is found to be less sensitive, while the depth of maximum dose, dmax, is more sensitive to the changes in BMI compared to the 6 MV beam. Tolerances are more stringent for PDD10 than PDD ratio for the 10 MV beam. PDD ratio, PDD10, and flatness must be monitored independently. Furthermore, off axis ratio alone cannot be used to monitor flatness. The effect of beam quality change in the absolute dose is clinically insignificant. PMID:26634604

  18. SU-E-T-24: A Dose Volume Comparison in Stereotactic Body Radiation Therapy Using Flattened and Un-Flattened Photon Beams

    SciTech Connect

    Pangam, S

    2015-06-15

    Purpose: Aim of this study is to compare the dose volume characteristics of 6X FFF (flattening Free Filter) Arc and 6X FB (flattened Beam) arc photon plans in SBRT technique. Methods: Eight patients who received linear Accelearator-based SBRT were retrospectively included in this study. A dose of 50 Gy was given to the target in five fractions. Same data set was used to generate plans for both FFF and FB. ITV was generated using maximum intensity projection and critical structures were derived using average intensity projection. PTV obtained by giving 0.5cm margin to ITV. Results: While both modalities can provide satisfactory target dose coverage, the dose to PTV was more heterogeneous in FFF than 6X FB plans in all cases. The doses in all plans were well below institutional constraints for both modalities. Comparing the results of Homogeneity Index(HI), Conformity Index(CI), PTV-D80% volume, D50% volume and D20% volume (Table-1 ) for both techniques, found all the indices are within limits of RTOG guidelines but the 6X FFF is superior in sparing normal tissues in compare with FB. In all cases studied, more treatment time was required for FB treatment delivery for a given prescription. The results indicate that for large dose delivery FFF is preferable as volumetric parameters like HI and CI are better and dose can be delivered in a short span of time. Conclusion: Both Flattened and Unflattened beam SBRT systems can provide adequate dose coverage for target tumor. While the unflattened beams deliver less normal tissue dose than Flattened beams in all cases. The magnitude of differences in normal tissue dose between both modalities was due to beam characterization of the beams. Flattened beam requires more Monitor Units to deliver similar target prescription to the tumor than unflattened beam SBRT systems. The results of this study may provide a general guideline for patient and treatment modality selection based on volumetric, tumor control and normal tissue

  19. Backscatter correction factor for megavoltage photon beam

    SciTech Connect

    Hu, Yida; Zhu, Timothy C.

    2011-10-15

    Purpose: For routine clinical dosimetry of photon beams, it is often necessary to know the minimum thickness of backscatter phantom material to ensure that full backscatter condition exists. Methods: In case of insufficient backscatter thickness, one can determine the backscatter correction factor, BCF(s,d,t), defined as the ratio of absorbed dose measured on the central-axis of a phantom with backscatter thickness of t to that with full backscatter for square field size s and forward depth d. Measurements were performed in SAD geometry for 6 and 15 MV photon beams using a 0.125 cc thimble chamber for field sizes between 10 x 10 and 30 x 30 cm at depths between d{sub max} (1.5 cm for 6 MV and 3 cm for 15 MV) and 20 cm. Results: A convolution method was used to calculate BCF using Monte-Carlo simulated point-spread kernels generated for clinical photon beams for energies between Co-60 and 24 MV. The convolution calculation agrees with the experimental measurements to within 0.8% with the same physical trend. The value of BCF deviates more from 1 for lower energies and larger field sizes. According to our convolution calculation, the minimum BCF occurs at forward depth d{sub max} and 40 x 40 cm field size, 0.970 for 6 MV and 0.983 for 15 MV. Conclusions: The authors concluded that backscatter thickness is 6.0 cm for 6 MV and 4.0 cm for 15 MV for field size up to 10 x 10 cm when BCF = 0.998. If 4 cm backscatter thickness is used, BCF is 0.997 and 0.983 for field size of 10 x 10 and 40 x 40 cm for 6 MV, and is 0.998 and 0.990 for 10 x 10 and 40 x 40 cm for 15 MV, respectively.

  20. Radiological considerations for POE-1 photon shutters, collimators and beam stops of the Biomedical Imaging and Therapy beamline at the Canadian Light Source

    NASA Astrophysics Data System (ADS)

    Asai, Juhachi; Wysokinski, Tomasz W.; Smith, Sheldon; Chapman, Dean

    2008-01-01

    A study of radiation levels due to primary and secondary gas bremsstrahlung is carried out for the BioMedical Imaging and Therapy (BMIT) beamline at the Canadian Light Source (CLS). The BMIT beamline, being built at present, is a major research and diagnostic tool for X-ray imaging and X-ray radiation therapy for animals and humans. For the BMIT beamline to be as flexible as possible, a movable tungsten collimator is designed. This can move vertically and assumes two positions; up and down. The BMIT beamline is, thus, able to perform two modes of operation: one white beam, the other monochromatic. Gas bremsstrahlung produced in the vacuum chamber propagates with synchrotron radiation and may enter the imaging or therapy hutch. In this study, the dose behind the collimator is investigated in each mode by assessing the energy deposition in a water phantom that surrounds the entire copper shutter-tungsten collimator unit. When estimating the dose, particular attention is given to the opening area of the collimator, since this passage leads to the imaging or therapy hutch. Also examined are the doses when a tungsten safety shutter is closed.

  1. Application of spherical diodes for megavoltage photon beams dosimetry

    SciTech Connect

    Barbés, Benigno; Azcona, Juan D.; Burguete, Javier; Martí-Climent, Josep M.

    2014-01-15

    Purpose: External beam radiation therapy (EBRT) usually uses heterogeneous dose distributions in a given volume. Designing detectors for quality control of these treatments is still a developing subject. The size of the detectors should be small to enhance spatial resolution and ensure low perturbation of the beam. A high uniformity in angular response is also a very important feature in a detector, because it has to measure radiation coming from all the directions of the space. It is also convenient that detectors are inexpensive and robust, especially to performin vivo measurements. The purpose of this work is to introduce a new detector for measuring megavoltage photon beams and to assess its performance to measure relative dose in EBRT. Methods: The detector studied in this work was designed as a spherical photodiode (1.8 mm in diameter). The change in response of the spherical diodes is measured regarding the angle of incidence, cumulated irradiation, and instantaneous dose rate (or dose per pulse). Additionally, total scatter factors for large and small fields (between 1 × 1 cm{sup 2} and 20 × 20 cm{sup 2}) are evaluated and compared with the results obtained from some commercially available ionization chambers and planar diodes. Additionally, the over-response to low energy scattered photons in large fields is investigated using a shielding layer. Results: The spherical diode studied in this work produces a high signal (150 nC/Gy for photons of nominal energy of 15 MV and 160 for 6 MV, after 12 kGy) and its angular dependence is lower than that of planar diodes: less than 5% between maximum and minimum in all directions, and 2% around one of the axis. It also has a moderated variation with accumulated dose (about 1.5%/kGy for 15 MV photons and 0.7%/kGy for 6 MV, after 12 kGy) and a low variation with dose per pulse (±0.4%), and its behavior is similar to commercial diodes in total scatter factor measurements. Conclusions: The measurements of relative dose

  2. Photon extrabunching in ultrabright twin beams measured by two-photon counting in a semiconductor

    PubMed Central

    Boitier, F.; Godard, A.; Dubreuil, N.; Delaye, P.; Fabre, C.; Rosencher, E.

    2011-01-01

    For many years twin beams originating from parametric down-converted light beams have aroused great interest and attention in the photonics community. One particular aspect of the twin beams is their peculiar intensity correlation functions, which are related to the coincidence rate of photon pairs. Here we take advantage of the huge bandwidth offered by two-photon absorption in a semiconductor to quantitatively determine correlation functions of twin beams generated by spontaneous parametric down-conversion. Compared with classical incoherent sources, photon extrabunching is unambiguously and precisely measured, originating from exact coincidence between down-converted pairs of photons, travelling in unison. These results strongly establish that two-photon counting in semiconductors is a powerful tool for the absolute measurement of light beam photon correlations at ultrashort timescales. PMID:21829187

  3. Photon beam description in PEREGRINE for Monte Carlo dose calculations

    SciTech Connect

    Cox, L. J., LLNL

    1997-03-04

    Goal of PEREGRINE is to provide capability for accurate, fast Monte Carlo calculation of radiation therapy dose distributions for routine clinical use and for research into efficacy of improved dose calculation. An accurate, efficient method of describing and sampling radiation sources is needed, and a simple, flexible solution is provided. The teletherapy source package for PEREGRINE, coupled with state-of-the-art Monte Carlo simulations of treatment heads, makes it possible to describe any teletherapy photon beam to the precision needed for highly accurate Monte Carlo dose calculations in complex clinical configurations that use standard patient modifiers such as collimator jaws, wedges, blocks, and/or multi-leaf collimators. Generic beam descriptions for a class of treatment machines can readily be adjusted to yield dose calculation to match specific clinical sites.

  4. Valley-dependent beam manipulators based on photonic graphene

    NASA Astrophysics Data System (ADS)

    Deng, Fu-Sheng; Sun, Yong; Dong, Li-Juan; Liu, Yan-Hong; Shi, Yun-Long

    2017-02-01

    Trigonal warping distortion in energy band lifts the degeneracy of two valleys (K and K' points) of graphene. In this situation, electron transport becomes valley dependent, which can be used to design the valley beam splitter, collimator, or guiding device. Here, valley-dependent beam manipulators are designed based on artificial photonic graphene. In this scheme, the finite-size artificial photonic graphene is intentionally designed to realize the novel device functionalities. This kind of valley-dependent beam manipulators can work at an arbitrary range of electromagnetic waves from microwave to visible light. It potentially paves the way for the application of photonic graphene in future integrated photonic devices.

  5. Characteristics of the photon beam from a new 25-MV linear accelerator

    SciTech Connect

    Aldrich, J.E.; Andrew, J.W.; Michaels, H.B.; O'Brien, P.F.

    1985-09-01

    The Therac 25 is a relatively compact therapy machine, the heart of which is a double-pass electron linear accelerator. The electron beam is injected into the accelerator at the treatment head end of the machine and is accelerated back down the arm to an energy of 13 MeV. At this end of the machine a magnet system reflects the beam back into the structure where it gains up to an additional 12 MeV of energy. After leaving the linear accelerator the beam is bent by an achromatic head magnet through 270 degrees to the treatment head. The machine produces eight electron beams and a 25-MV photon beam. In this work only the parameters of the photon beam are addressed based on measurements at the first two clinical sites. Percentage depth doses, tissue phantom ratios, and beam symmetry and stability are presented and discussed.

  6. Characteristics of the photon beam from a new 25-MV linear accelerator.

    PubMed

    Aldrich, J E; Andrew, J W; Michaels, H B; O'Brien, P F

    1985-01-01

    The Therac 25 is a relatively compact therapy machine, the heart of which is a double-pass electron linear accelerator. The electron beam is injected into the accelerator at the treatment head end of the machine and is accelerated back down the arm to an energy of 13 MeV. At this end of the machine a magnet system reflects the beam back into the structure where it gains up to an additional 12 MeV of energy. After leaving the linear accelerator the beam is bent by an achromatic head magnet through 270 degrees to the treatment head. The machine produces eight electron beams and a 25-MV photon beam. In this work only the parameters of the photon beam are addressed based on measurements at the first two clinical sites. Percentage depth doses, tissue phantom ratios, and beam symmetry and stability are presented and discussed.

  7. Formation of collimated beams behind the woodpile photonic crystal

    SciTech Connect

    Trull, J.; Maigyte, L.; Cojocaru, C.; Mizeikis, V.; Malinauskas, M.; Rutkauskas, M.; Peckus, M.; Sirutkaitis, V.; Juodkazis, S.; Staliunas, K.

    2011-09-15

    We experimentally observe formation of narrow laser beams behind the woodpile photonic crystal, when the beam remains well collimated in free propagation behind the crystal. We show that the collimation depends on the input laser beam's focusing conditions, and we interpret theoretically the observed effect by calculating the spatial dispersion of propagation eigenmodes and by numerical simulation of paraxial propagation model.

  8. Out of Field Doses in Clinical Photon and Proton Beam

    NASA Astrophysics Data System (ADS)

    Kubančák, Ján

    2010-01-01

    Out-of-field doses in homogenous cubical polymethylmethacrylate (PMMA) phantom were studied in this work. Measurements were performed in clinical 171 MeV proton and megavoltae photon beam. As detectors, CaSO:Dy thermoluminescent detectors were used. According to expectancy, results showed that out-of-field doses are substantially lower for clinical proton beam in comparison with clinical proton beam.

  9. Evaluation of beam hardening and photon scatter by brass compensator for IMRT.

    PubMed

    Hashimoto, Shimpei; Karasawa, Katsuyuki; Fujita, Yukio; Miyashita, Hisayuki; Chang, Weishan; Kawachi, Toru; Katayose, Tetsurou; Kobayashi, Nao; Kunieda, Etsuo; Saitoh, Hidetoshi

    2012-11-01

    When a brass compensator is set in a treatment beam, beam hardening may take place. This variation of the energy spectrum may affect the accuracy of dose calculation by a treatment planning system and the results of dose measurement of brass compensator intensity modulated radiation therapy (IMRT). In addition, when X-rays pass the compensator, scattered photons are generated within the compensator. Scattered photons may affect the monitor unit (MU) calculation. In this study, to evaluate the variation of dose distribution by the compensator, dose distribution was measured and energy spectrum was simulated using the Monte Carlo method. To investigate the influence of beam hardening for dose measurement using an ionization chamber, the beam quality correction factor was determined. Moreover, to clarify the effect of scattered photons generated within the compensator for the MU calculation, the head scatter factor was measured and energy spectrum analyses were performed. As a result, when X-rays passed the brass compensator, beam hardening occurred and dose distribution was varied. The variation of dose distribution and energy spectrum was larger with decreasing field size. This means that energy spectrum should be reproduced correctly to obtain high accuracy of dose calculation for the compensator IMRT. On the other hand, the influence of beam hardening on k(Q) was insignificant. Furthermore, scattered photons were generated within the compensator, and scattered photons affect the head scatter factor. These results show that scattered photons must be taken into account for MU calculation for brass compensator IMRT.

  10. MO-G-BRF-07: Optical Characterization of Novel Terbium-Doped Nanophosphors Excited by Clinical Electron and Photon Beams for Potential Use in Molecular Imaging Or Photodynamic Therapy

    SciTech Connect

    Darafsheh, A; Paik, T; Tenuto, M; Najmr, S; Friedberg, J; Murray, C; Finlay, J

    2014-06-15

    Purpose: Optical properties of terbium (Tb3+)-doped gadolinium trifluoride (GdF3) nanoplates irradiated by electron and photon beams were investigated for their potential as optical probes. The contribution of induced Cerenkov radiation in exciting the nanophosphors was investigated as well. Methods: The emission spectra of Terbium-doped GdF3 dispersed in hexane, embedded in tissue mimicking phantoms were collected by an optical fiber connected to a CCD-coupled spectrograph, while the samples were irradiated by a medical linear accelerator with electron beams of energies 6, 9, 12, 16, and 20 MeV or X-ray beams of energies of 6, and 15 MV. The contribution of induced Cerenkov radiation in exciting the nanophosphores was investigated in a dedicated experimental apparatus through optical isolation of the samples and also by using 125 kVp X-ray beams whose energy is below the threshold for generating Cerenkov radiation in that medium. Results: Terbium-doped GdF3 nanoplates show characteristic cathodoluminescence emission peaks at 488, 543, 586, and 619 nm, which are responsible for the characteristic f-f transition of terbium ion. In a series of experiments, the contribution of Cerenkov radiation in the luminescence of such nanophosphors was ruled out. Conclusion: We have characterized the optical properties of Terbium-doped GdF3 nanoplates. Such nanocrystals with emission tunability and high surface area that facilitates attachment with targeting reagents are promising in situ light source candidates for molecular imaging or exciting a photosensitizer for ultralow fluence photodynamic therapy. This work is supported by the Department of Radiation Oncology at the University of Pennsylvania, the American Cancer Society through IRG-78-002-28, and the University of Pennsylvania's Nano/Bio Interface Center through NSEC DMR08-32802.

  11. Ion Beam Therapy in Europe

    NASA Astrophysics Data System (ADS)

    Kraft, Gerhard

    2009-03-01

    At present, seven facilities in Europe treat deep-seated tumors with particle beams, six with proton beams and one with carbon ions. Three of these facilities are in Moscow, St. Petersburg and Dubna, Russia. Other facilities include the TSL Uppsala, Sweden, CPO Orsay, France, and PSI Villigen, Switzerland, all for proton therapy, and GSI, Darmstadt, Germany, which utilizes carbon ions only. But only two of these facilities irradiate with scanned ion beams: the Paul Scherer Institute (PSI), Villigen (protons) and the Gesellschaft für Schwerionenforschung (GSI), Darmstadt. These two facilities are experimental units within physics laboratories and have developed the technique of intensity-modulated beam scanning in order to produce irradiation conforming to a 3-D target. There are three proton centers presently under construction in Munich, Essen and Orsay, and the proton facility at PSI has added a superconducting accelerator connected to an isocentric gantry in order to become independent of the accelerator shared with the physics research program. The excellent clinical results using carbon ions at National Institute of Radiological Science (NIRS) in Chiba and GSI have triggered the construction of four new heavy-ion therapy projects (carbon ions and protons), located in Heidelberg, Pavia, Marburg and Kiel. The projects in Heidelberg and Pavia will begin patient treatment in 2009, and the Marburg and Kiel projects will begin in 2010 and 2011, respectively. These centers use different accelerator designs but have the same kind of treatment planning system and use the same approach for the calculation of the biological effectiveness of the carbon ions as developed at GSI [1]. There are many other planned projects in the works. Do not replace the word "abstract," but do replace the rest of this text. If you must insert a hard line break, please use Shift+Enter rather than just tapping your "Enter" key. You may want to print this page and refer to it as a style

  12. Parameterization of photon beam dosimetry for a linear accelerator

    SciTech Connect

    Lebron, Sharon; Barraclough, Brendan; Lu, Bo; Yan, Guanghua; Kahler, Darren; Li, Jonathan G.; Liu, Chihray

    2016-02-15

    Purpose: In radiation therapy, accurate data acquisition of photon beam dosimetric quantities is important for (1) beam modeling data input into a treatment planning system (TPS), (2) comparing measured and TPS modeled data, (3) the quality assurance process of a linear accelerator’s (Linac) beam characteristics, (4) the establishment of a standard data set for comparison with other data, etcetera. Parameterization of the photon beam dosimetry creates a data set that is portable and easy to implement for different applications such as those previously mentioned. The aim of this study is to develop methods to parameterize photon beam dosimetric quantities, including percentage depth doses (PDDs), profiles, and total scatter output factors (S{sub cp}). Methods: S{sub cp}, PDDs, and profiles for different field sizes, depths, and energies were measured for a Linac using a cylindrical 3D water scanning system. All data were smoothed for the analysis and profile data were also centered, symmetrized, and geometrically scaled. The S{sub cp} data were analyzed using an exponential function. The inverse square factor was removed from the PDD data before modeling and the data were subsequently analyzed using exponential functions. For profile modeling, one halfside of the profile was divided into three regions described by exponential, sigmoid, and Gaussian equations. All of the analytical functions are field size, energy, depth, and, in the case of profiles, scan direction specific. The model’s parameters were determined using the minimal amount of measured data necessary. The model’s accuracy was evaluated via the calculation of absolute differences between the measured (processed) and calculated data in low gradient regions and distance-to-agreement analysis in high gradient regions. Finally, the results of dosimetric quantities obtained by the fitted models for a different machine were also assessed. Results: All of the differences in the PDDs’ buildup and the

  13. Proton beam therapy control system

    DOEpatents

    Baumann, Michael A; Beloussov, Alexandre V; Bakir, Julide; Armon, Deganit; Olsen, Howard B; Salem, Dana

    2013-12-03

    A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.

  14. Proton beam therapy control system

    DOEpatents

    Baumann, Michael A.; Beloussov, Alexandre V.; Bakir, Julide; Armon, Deganit; Olsen, Howard B.; Salem, Dana

    2008-07-08

    A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.

  15. Proton beam therapy control system

    DOEpatents

    Baumann, Michael A; Beloussov, Alexandre V; Bakir, Julide; Armon, Deganit; Olsen, Howard B; Salem, Dana

    2013-06-25

    A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.

  16. Proton beam therapy control system

    DOEpatents

    Baumann, Michael A.; Beloussov, Alexandre V.; Bakir, Julide; Armon, Deganit; Olsen, Howard B.; Salem, Dana

    2010-09-21

    A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.

  17. Photonic crystal devices formed by a charged-particle beam

    DOEpatents

    Lin, Shawn-Yu; Koops, Hans W. P.

    2000-01-01

    A photonic crystal device and method. The photonic crystal device comprises a substrate with at least one photonic crystal formed thereon by a charged-particle beam deposition method. Each photonic crystal comprises a plurality of spaced elements having a composition different from the substrate, and may further include one or more impurity elements substituted for spaced elements. Embodiments of the present invention may be provided as electromagnetic wave filters, polarizers, resonators, sources, mirrors, beam directors and antennas for use at wavelengths in the range from about 0.2 to 200 microns or longer. Additionally, photonic crystal devices may be provided with one or more electromagnetic waveguides adjacent to a photonic crystal for forming integrated electromagnetic circuits for use at optical, infrared, or millimeter-wave frequencies.

  18. TH-C-12A-10: Surface Dose Enhancement Using Novel Hybrid Electron and Photon Low-Z Therapy Beams: Monte Carlo Simulation

    SciTech Connect

    Parsons, C; Parsons, D; Robar, J; Kelly, R

    2014-06-15

    Purpose: The introduction of the TrueBeam linac platform provides access to an in-air target assembly making it possible to apply novel treatments using multiple target designs. One such novel treatment uses multiple low-Z targets to enhance surface dose replacing the use of synthetic tissue equivalent material (bolus). This treatment technique will decrease the common dosimetric and set up errors prevalent in using physical treatment accessories like bolus. The groundwork for a novel treatment beam used to enhance surface dose to within 80-100% of the dose at dmax by utilizing low-Z (Carbon) targets of various percent CSDA range thickness operated at 2.5–4 MeV used in conjunction with a clinical 6 MV beam is presented herein. Methods: A standard Monte Carlo model of a Varian Clinac accelerator was developed to manufacturers specifications. Simulations were performed using Be, C, AL, and C, as potential low-Z targets, placed in the secondary target position. The results determined C to be the target material of choice. Simulations of 15, 30 and 60% CSDA range C beams were propagated through slab phantoms. The resulting PDDs were weighted and combined with a standard 6 MV treatment beam. Versions of the experimental targets were installed into a 2100C Clinac and the models were validated. Results: Carbon was shown to be the low-Z material of choice for this project. Using combinations of 15, 30, 60% CSDA beams operated at 2.5 and 4 MeV in combination with a standard 6 MV treatment beam the surface dose was shown to be enhanced to within 80–100% the dose at dmax. Conclusion: The modeled low-Z beams were successfully validated using machined versions of the targets. Water phantom measurements and slab phantom simulations show excellent correlation. Patient simulations are now underway to compare the use of bolus with the proposed novel beams. NSERC.

  19. Optical microscope using an interferometric source of two-color, two-beam entangled photons

    DOEpatents

    Dress, William B.; Kisner, Roger A.; Richards, Roger K.

    2004-07-13

    Systems and methods are described for an optical microscope using an interferometric source of multi-color, multi-beam entangled photons. A method includes: downconverting a beam of coherent energy to provide a beam of multi-color entangled photons; converging two spatially resolved portions of the beam of multi-color entangled photons into a converged multi-color entangled photon beam; transforming at least a portion of the converged multi-color entangled photon beam by interaction with a sample to generate an entangled photon specimen beam; and combining the entangled photon specimen beam with an entangled photon reference beam within a single beamsplitter. An apparatus includes: a multi-refringent device providing a beam of multi-color entangled photons; a condenser device optically coupled to the multi-refringent device, the condenser device converging two spatially resolved portions of the beam of multi-color entangled photons into a converged multi-color entangled photon beam; a beam probe director and specimen assembly optically coupled to the condenser device; and a beam splitter optically coupled to the beam probe director and specimen assembly, the beam splitter combining an entangled photon specimen beam from the beam probe director and specimen assembly with an entangled photon reference beam.

  20. A photon beam position monitor for SSRL beamline 9

    SciTech Connect

    Cerino, J.A.; Rabedeau, T.; Bowen, W.

    1995-10-01

    We present here the concept of a simple one dimensional photon beam position monitor for use with high power synchrotron radiation beams. It has micron resolution, reasonable linearity in an inexpensive design. Most important, is its insensitivity to diffusely scattered low energy radiation from components upstream of the monitor.

  1. Applied photonic therapy in veterinary medicine

    NASA Astrophysics Data System (ADS)

    Wood, Terry R.; McLaren, Brian C.

    2005-04-01

    There can be no question that specific systemic physiological results occur, when red light (660nm) is applied to the skin, it is now more a question of detailed mechanisms. Before gathering statistically signifcant clinical trial data, it is important to first enumerate the type of results observed in practice. Case histories are presented highlighting the use of photonic therapy in veterinary medicine. Over 900 surgical procedures have been performed and documented, utilizing the principles of photonic therapy, and while hemostasis, pain relief, and nausea relief, were the primary goals, the peri-operative death rate, the post-operative seroma, and post-operative infection were reduced to almost zero, and there was a noticeable increase in the healing rate. Scientifically applied photonic therapy, rather than supplanting conventional veterinary medicine, compliments and increases the veterinarian's set of skills. This paper proposes a hypothesis of how 660 nm light applied to specific points on the skin, produces various physiological changes in animals. By using animals, there can be no placebo, hypnotic or psychosomatic confounding effects.

  2. A surface energy spectral study on the bone heterogeneity and beam obliquity using the flattened and unflattened photon beams

    PubMed Central

    Chow, James C.L.; Owrangi, Amir M.

    2016-01-01

    Aim Using flattened and unflattened photon beams, this study investigated the spectral variations of surface photon energy and energy fluence in the bone heterogeneity and beam obliquity. Background Surface dose enhancement is a dosimetric concern when using unflattened photon beam in radiotherapy. It is because the unflattened photon beam contains more low-energy photons which are removed by the flattening filter of the flattened photon beam. Materials and methods We used a water and bone heterogeneity phantom to study the distributions of energy, energy fluence and mean energy of the 6 MV flattened and unflattened photon beams (field size = 10 cm × 10 cm) produced by a Varian TrueBEAM linear accelerator. These elements were calculated at the phantom surfaces using Monte Carlo simulations. The photon energy and energy fluence calculations were repeated with the beam angle turned from 0° to 15°, 30° and 45° in the water and bone phantom. Results Spectral results at the phantom surfaces showed that the unflattened photon beams contained more photons concentrated mainly in the low-energy range (0–2 MeV) than the flattened beams associated with a flattening filter. With a bone layer of 1 cm under the phantom surface and within the build-up region of the 6 MV photon beam, it is found that both the flattened and unflattened beams had slightly less photons in the energy range <0.4 MeV compared to the water phantom. This shows that the presence of the bone decreased the low-energy photon backscatters to the phantom surface. When both the flattened and unflattened photon beams were rotated from 0° to 45°, the number of photon and mean photon energy increased. This indicates that both photon beams became more hardened or penetrate when the beam angle increased. In the presence of bone, the mean energies of both photon beams increased. This is due to the absorption of low-energy photons by the bone, resulting in more beam hardening. Conclusions This study

  3. Photon beam characteristics on the MM50 racetrack microtron and a new approach for beam quality determination.

    PubMed

    Karlsson, M; Nyström, H; Svensson, H

    1993-01-01

    The photon beams of the MM50 racetrack microtron have special characteristics which make them more suitable than conventional photon beams for precision radiation therapy with good dosimetric control. The beam flattening is obtained by the scanning of an elementary beam instead of using a flattening filter. This will give a number of advantages such as the possibility to optimize field flattening to individual field forms and field sizes. The radiation quality is the same across the whole beam, which gives smaller changes in dose profiles with depth and also makes it easier to perform careful dose planning. Beam collimation is mainly performed by a multileaf collimator and the special design of the treatment head gives nearly ideal characteristics for dose determination in an arbitrary point in the treatment fields. The output factor has been shown to depend almost solely on scattering within the treatment field. The conventional methods for beam quality characterization have been found less suitable at high energies and a new method based on HVL measurements in water is proposed.

  4. Measurements and simulations of focused beam for orthovoltage therapy

    SciTech Connect

    Abbas, Hassan; Mahato, Dip N.; Satti, Jahangir; MacDonald, C. A.

    2014-04-15

    Purpose: Megavoltage photon beams are typically used for therapy because of their skin-sparing effect. However, a focused low-energy x-ray beam would also be skin sparing, and would have a higher dose concentration at the focal spot. Such a beam can be produced with polycapillary optics. MCNP5 was used to model dose profiles for a scanned focused beam, using measured beam parameters. The potential of low energy focused x-ray beams for radiation therapy was assessed. Methods: A polycapillary optic was used to focus the x-ray beam from a tungsten source. The optic was characterized and measurements were performed at 50 kV. PMMA blocks of varying thicknesses were placed between optic and the focal spot to observe any variation in the focusing of the beam after passing through the tissue-equivalent material. The measured energy spectrum was used to model the focused beam in MCNP5. A source card (SDEF) in MCNP5 was used to simulate the converging x-ray beam. Dose calculations were performed inside a breast tissue phantom. Results: The measured focal spot size for the polycapillary optic was 0.2 mm with a depth of field of 5 mm. The measured focal spot remained unchanged through 40 mm of phantom thickness. The calculated depth dose curve inside the breast tissue showed a dose peak several centimeters below the skin with a sharp dose fall off around the focus. The percent dose falls below 10% within 5 mm of the focus. It was shown that rotating the optic during scanning would preserve the skin-sparing effect of the focused beam. Conclusions: Low energy focused x-ray beams could be used to irradiate tumors inside soft tissue within 5 cm of the surface.

  5. NLC Polarized Positron Photon Beam Target Thermal Structural Modeling

    SciTech Connect

    Stein, W; Sheppard, J C

    2002-06-11

    The NLC polarized positron photon beam target is a 0.4 radiation length thick titanium target. Energy deposition from one pulse occurs over 266 nano-seconds and results in heating of the target and pressure pulses straining the material. The 22.1 MeV photon beam has a spot size of 0.75 mm and results in a maximum temperature jump of 233 C. Stresses are induced in the material from thermal expansion of the hotter material. Peak effective stresses reach 19 Ksi (1.34 x 10{sup 8} Pa), which is lower than the yield strength of a titanium alloy by a factor of six.

  6. Efficient photon beam dose calculations using DOSXYZnrc with BEAMnrc.

    PubMed

    Kawrakow, I; Walters, B R B

    2006-08-01

    This study examines the efficiencies of doses calculated using DOSXYZnrc for 18 MV (10 X 10 cm2 field size) and 6 MV (10 X 10 cm2 and 20 X 20 cm2 field sizes) photon beams simulated using BEAMnrc. Both phase-space sources and full BEAMnrc simulation sources are used in the DOSXYZnrc calculations. BEAMnrc simulation sources consist of a BEAMnrc accelerator simulation compiled as a shared library and run by the user code (DOSXYZnrc in this case) to generate source particles. Their main advantage is in eliminating the need to store intermediate phase-space files. In addition, the efficiency improvements due to photon splitting and particle recycling in the DOSXYZnrc simulation are examined. It is found that photon splitting increases dose calculation efficiency by a factor of up to 6.5, depending on beam energy, field size, voxel size, and the type of secondary collimation used in the BEAMnrc simulation (multileaf collimator vs photon jaws). The optimum efficiency with photon splitting is approximately 55% higher than that with particle recycling, indicating that, while most of the gain is due to time saved by reusing source particle data, there is significant gain due to the uniform distribution of interaction sites and faster DOSXYZnrc simulation time when photon splitting is employed. Use of optimized directional bremsstrahlung splitting in the BEAMnrc simulation sources increases the efficiency of photon beam simulations sufficiently that the peak efficiencies (i.e., with optimum setting of the photon splitting number) of DOSXYZnrc simulations using these sources are only 3-13% lower than those with phase-space file sources. This points towards eliminating the need for storing intermediate phase-space files.

  7. The Evaluation and Study of Modern Radiation Dosimetry Methods as Applied to Advanced Radiation Therapy Treatments Using Intensity Modulated Megavoltage Photon Beams

    NASA Astrophysics Data System (ADS)

    Stambaugh, Cassandra K. K.

    The purpose of this work is to evaluate quasi-3D arrays for use with intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) and to determine their clinical relevance. This is achieved using a Delta4 from Scandidos and ArcCheck from Sun Nuclear and the associated software. While certain aspects of these devices and software have been previously evaluated, the main goal of this work is to evaluate the new aspects, such as reconstructing dose on a patient CT set, and extending the capabilities. This includes the capability to reconstruct the dose based on a helical delivery as well as studying the dose to a moving target using measurement-guided motion simulations. It was found that Sun Nuclear's ArcCheck/3DVH system exhibited excellent agreement for dose reconstruction for IMRT/VMAT using a traditional C-arm linear accelerator and stringent 2%/2mm comparison constraints. It also is a powerful tool for measurement-guided dose estimates for moving targets, allowing for many simulations to be performed based on one measurement and the target motion data. For dose reconstruction for a helical delivery, the agreement was not as good for the stringent comparison but was reasonable for the clinically acceptable 3%/3mm comparison. Scandidos' Delta4 shows good agreement with stringent 2%/2mm constraints for its dose reconstruction on the phantom. However, the dose reconstruction on the patient CT set was poor and needs more work. Overall, it was found that quasi-3D arrays are powerful tools for dose reconstruction and treatment plan comparisons. The ability to reconstruct the dose allows for a dose resolution comparable to the treatment plan, which negates the previous issues with inadequate sampling and resolution issues found when just comparing the diodes. The ability to quickly and accurately compare many plans and target motions with minimum setup makes the quasi-3D array an attractive tool for both commissioning and patient specific

  8. Metastable Krypton Beam Source via Two-Photon Pumping Technique

    SciTech Connect

    Wong, W.W.; Young, L.

    2003-01-01

    Metastable beams of rare gas atoms have wide applications in chemical analysis of samples, as well as in aiding understanding of fundamental processes and physical attributes. Most current sources of metastable rare gas atomic beams, however, are limited in their flux density, which greatly reduces their utility in applications such as low level trace analysis and precision measurements. Previous work has demonstrated feasibility of metastable krypton production via two-photon pumping, and this paper extends that possibility into beam form. Further optimization on this scheme, moreover, promises 100-fold increase of metastable krypton flux density over that of an rf-driven discharge.

  9. Application of Cerenkov radiation generated in plastic optical fibers for therapeutic photon beam dosimetry.

    PubMed

    Jang, Kyoung Won; Yagi, Takahiro; Pyeon, Cheol Ho; Yoo, Wook Jae; Shin, Sang Hun; Jeong, Chiyoung; Min, Byung Jun; Shin, Dongho; Misawa, Tsuyoshi; Lee, Bongsoo

    2013-02-01

    A Cerenkov fiber-optic dosimeter (CFOD) is fabricated using plastic optical fibers to measure Cerenkov radiation induced by a therapeutic photon beam. We measured the Cerenkov radiation generated in optical fibers in various irradiation conditions to evaluate the usability of Cerenkov radiation for a photon beam therapy dosimetry. As a results, the spectral peak of Cerenkov radiation was measured at a wavelength of 515 nm, and the intensity of Cerenkov radiation increased linearly with increasing irradiated length of the optical fiber. Also, the intensity peak of Cerenkov radiation was measured in the irradiation angle range of 30 to 40 deg. In the results of Monte Carlo N-particle transport code simulations, the relationship between fluxes of electrons over Cerenkov threshold energy and energy deposition of a 6 MV photon beam had a nearly linear trend. Finally, percentage depth doses for the 6 MV photon beam could be obtained using the CFOD and the results were compared with those of an ionization chamber. Here, the mean dose difference was about 0.6%. It is anticipated that the novel and simple CFOD can be effectively used for measuring depth doses in radiotherapy dosimetry.

  10. Future Directions in Ion Beam Therapy

    NASA Astrophysics Data System (ADS)

    Habermehl, Daniel; Combs, Stephanie; Debus, Jürgen

    There is a growing interest in ion beam therapy (IBT) worldwide which has led to an increasing number of new treatment facilities. This development is accompanied by intensive radiobiological, physical and clinical research of both proton therapy (PT) and carbon ion radiotherapy (CIRT). Current developments in IBT with high impact for future challenges will be summarized in this chapter.

  11. Plastic scintillator block as photon beam monitor for EGRET calibration

    NASA Technical Reports Server (NTRS)

    Lin, Y. C.; Hofstadter, R.; Nolan, P. L.; Walker, A. H.; Mattox, J. R.; Hughes, E. B.

    1991-01-01

    The EGRET (Energetic Gamma Ray Experiment Telescope) detector has been calibrated at SLAC (Stanford Linear Accelerator) and, to a lesser degree, at the MIT Bates Linear Accelerator Center. To monitor the photon beams for the calibration, a plastic scintillator block, 5 cm x 5 cm in cross section, 15 cm in length, and viewed by a single photomultiplier tube, was used for the entire beam energy range of 15 MeV to 10 GeV. The design operation, and method of analysis of the beam intensity are presented. A mathematical framework has been developed to treat the general case of a beam with multiphoton beam pulses and with a background component. A procedure to deal with the fluctuations of the beam intensity over a data-taking period was also developed. The photon beam monitor is physically sturdy, electronically steady, simple to construct, and easy to operate. Its major merits lie in its sheer simplicity of construction and operation and in the wide energy range it can cover.

  12. Radial Moment Calculations of Coupled Electron-Photon Beams

    SciTech Connect

    FRANKE,BRIAN C.; LARSEN,EDWARD W.

    2000-07-19

    The authors consider the steady-state transport of normally incident pencil beams of radiation in slabs of material. A method has been developed for determining the exact radial moments of 3-D beams of radiation as a function of depth into the slab, by solving systems of 1-D transport equations. They implement these radial moment equations in the ONEBFP discrete ordinates code and simulate energy-dependent, coupled electron-photon beams using CEPXS-generated cross sections. Modified P{sub N} synthetic acceleration is employed to speed up the iterative convergence of the 1-D charged particle calculations. For high-energy photon beams, a hybrid Monte Carlo/discrete ordinates method is examined. They demonstrate the efficiency of the calculations and make comparisons with 3-D Monte Carlo calculations. Thus, by solving 1-D transport equations, they obtain realistic multidimensional information concerning the broadening of electron-photon beams. This information is relevant to fields such as industrial radiography, medical imaging, radiation oncology, particle accelerators, and lasers.

  13. Radiosurgery with unflattened 6-MV photon beams.

    PubMed

    O'Brien, P F; Gillies, B A; Schwartz, M; Young, C; Davey, P

    1991-01-01

    One of the major drawbacks to doing stereotactic radiosurgery with a linear accelerator is the long time required to deliver the target dose. Single fractions of 25 Gy delivered at the isocenter and at depth in the skull may require beam times in excess of 15 min for a typical linear accelerator with a maximum dose rate of 250 cGy/min in tissue. In an effort to decrease the treatment time for this technique, the flattening filter has been removed from an AECL Therac-6 linear accelerator and the characteristics of the resulting beam have been measured. Flatness is acceptable for the field sizes used with this technique and the dose rate is increased by a factor of 2.75.

  14. Particle beam therapy (hadrontherapy): basis for interest and clinical experience.

    PubMed

    Orecchia, R; Zurlo, A; Loasses, A; Krengli, M; Tosi, G; Zurrida, S; Zucali, P; Veronesi, U

    1998-03-01

    The particle or hadron beams deployed in radiotherapy (protons, neutrons and helium, carbon, oxygen and neon ions) have physical and radiobiological characteristics which differ from those of conventional radiotherapy beams (photons) and which offer a number of theoretical advantages over conventional radiotherapy. After briefly describing the properties of hadron beams in comparison to photons, this review discusses the indications for hadrontherapy and analyses accumulated experience on the use of this modality to treat mainly neoplastic lesions, as published by the relatively few hadrontherapy centres operating around the world. The analysis indicates that for selected patients and tumours (particularly uveal melanomas and base of skull/spinal chordomas and chondrosarcomas), hadrontherapy produces greater disease-free survival. The advantages of hadrontherapy are most promisingly realised when used in conjunction with modern patient positioning, radiation delivery and focusing techniques (e.g. on-line imaging, three-dimensional conformal radiotherapy) developed to improve the efficacy of photon therapy. Although the construction and running costs of hadrontherapy units are considerably greater than those of conventional facilities, a comprehensive analysis that considers all the costs, particularly those resulting from the failure of less effective conventional radiotherapy, might indicate that hadrontherapy could be cost effective. In conclusion, the growing interest in this form of treatment seems to be fully justified by the results obtained to date, although more efficacy and dosing studies are required.

  15. Integral window/photon beam position monitor and beam flux detectors for x-ray beams

    DOEpatents

    Shu, Deming; Kuzay, Tuncer M.

    1995-01-01

    A monitor/detector assembly in a synchrotron for either monitoring the position of a photon beam or detecting beam flux may additionally function as a vacuum barrier between the front end and downstream segment of the beamline in the synchrotron. A base flange of the monitor/detector assembly is formed of oxygen free copper with a central opening covered by a window foil that is fused thereon. The window foil is made of man-made materials, such as chemical vapor deposition diamond or cubic boron nitrate and in certain configurations includes a central opening through which the beams are transmitted. Sensors of low atomic number materials, such as aluminum or beryllium, are laid on the window foil. The configuration of the sensors on the window foil may be varied depending on the function to be performed. A contact plate of insulating material, such as aluminum oxide, is secured to the base flange and is thereby clamped against the sensor on the window foil. The sensor is coupled to external electronic signal processing devices via a gold or silver lead printed onto the contact plate and a copper post screw or alternatively via a copper screw and a copper spring that can be inserted through the contact plate and coupled to the sensors. In an alternate embodiment of the monitor/detector assembly, the sensors are sandwiched between the window foil of chemical vapor deposition diamond or cubic boron nitrate and a front foil made of similar material.

  16. High intensity X/γ photon beams for nuclear physics and photonics

    NASA Astrophysics Data System (ADS)

    Serafini, L.; Alesini, D.; Bacci, N.; Bliss, N.; Cassou, K.; Curatolo, C.; Drebot, I.; Dupraz, K.; Giribono, A.; Petrillo, V.; Palumbo, L.; Vaccarezza, C.; Variola, A.; Zomer, F.

    2016-05-01

    In this manuscript we review the challenges of Compton backscattering sources in advancing photon beam performances in the 1 - 20 MeV energy range, underlining the design criteria bringing to maximum spectral luminosity and briefly describing the main achievements in conceiving and developing new devices (multi-bunch RF cavities and Laser recirculators) for the case of ELI-NP Gamma Beam System (ELI-NP-GBS).

  17. Two-dimensional silicon-based detectors for ion beam therapy

    NASA Astrophysics Data System (ADS)

    Martišíková, M.; Granja, C.; Jakůbek, J.; Hartmann, B.; Telsemeyer, J.; Huber, L.; Brons, S.; Pospíšil, S.; Jäkel, O.

    2012-02-01

    Radiation therapy with ion beams is a highly precise kind of cancer treatment. As ion beams traverse material, the highest ionization density occurs at the end of their path. Due to this Bragg-peak, ion beams enable higher dose conformation to the tumor and increased sparing of the surrounding tissue, in comparison to standard radiation therapy using high energy photons. Ions heavier than protons offer in addition increased biological effectiveness and lower scattering. The Heidelberg Ion Beam Therapy Center (HIT) is a state-of-the-art ion beam therapy facility and the first hospital-based facility in Europe. It provides proton and carbon ion treatments. A synchrotron is used for ion acceleration. For dose delivery to the patient, narrow pencil-like beams are scanned over the target volume.

  18. A pencil beam algorithm for helium ion beam therapy

    SciTech Connect

    Fuchs, Hermann; Stroebele, Julia; Schreiner, Thomas; Hirtl, Albert; Georg, Dietmar

    2012-11-15

    Purpose: To develop a flexible pencil beam algorithm for helium ion beam therapy. Dose distributions were calculated using the newly developed pencil beam algorithm and validated using Monte Carlo (MC) methods. Methods: The algorithm was based on the established theory of fluence weighted elemental pencil beam (PB) kernels. Using a new real-time splitting approach, a minimization routine selects the optimal shape for each sub-beam. Dose depositions along the beam path were determined using a look-up table (LUT). Data for LUT generation were derived from MC simulations in water using GATE 6.1. For materials other than water, dose depositions were calculated by the algorithm using water-equivalent depth scaling. Lateral beam spreading caused by multiple scattering has been accounted for by implementing a non-local scattering formula developed by Gottschalk. A new nuclear correction was modelled using a Voigt function and implemented by a LUT approach. Validation simulations have been performed using a phantom filled with homogeneous materials or heterogeneous slabs of up to 3 cm. The beams were incident perpendicular to the phantoms surface with initial particle energies ranging from 50 to 250 MeV/A with a total number of 10{sup 7} ions per beam. For comparison a special evaluation software was developed calculating the gamma indices for dose distributions. Results: In homogeneous phantoms, maximum range deviations between PB and MC of less than 1.1% and differences in the width of the distal energy falloff of the Bragg-Peak from 80% to 20% of less than 0.1 mm were found. Heterogeneous phantoms using layered slabs satisfied a {gamma}-index criterion of 2%/2mm of the local value except for some single voxels. For more complex phantoms using laterally arranged bone-air slabs, the {gamma}-index criterion was exceeded in some areas giving a maximum {gamma}-index of 1.75 and 4.9% of the voxels showed {gamma}-index values larger than one. The calculation precision of the

  19. High-efficiency beam bending using graded photonic crystals.

    PubMed

    Oner, B B; Turduev, M; Kurt, H

    2013-05-15

    We explore beam-bending properties of graded index (GRIN) waveguide with hyperbolic secant profile. The transmission efficiency and bandwidth features are extracted for GRIN photonic crystal (PC) media composed of dielectric rods. Light guiding performance of the GRIN PC medium is analyzed for 90° and 180° waveguide bends. The finite-difference time-domain method is deployed to investigate the performance of the designed GRIN waveguides. By the help of proposed photonic configuration, bending of light is achieved with a high efficiency within a broad bandwidth, which promotes the use of GRIN PC structures for efficient light-bending purposes.

  20. Photon Beam Diagnostics for VISA FEL

    SciTech Connect

    Murokh, A.; Pellegrini, C.; Rosenzweig, J.; Frigola, P.; Musumeci, P.; Tremaine, A.; Babzien, M.; Ben-Zvi, I.; Doyuran, A.; Johnson, E.; Skaritka, J.; Wang, X.J.; Van Bibber, K.; Hill, J.M.; LeSage, G.P.; Nguyen, D.; Cornacchia, M.

    1999-11-05

    The VISA (Visible to Infrared SASE Amplifier) project is designed to be a SASE-FEL driven to saturation in the sub-micron wavelength region. Its goal is to test various aspects of the existing theory of Self-Amplified Spontaneous Emission, as well as numerical codes. Measurements include: angular and spectral distribution of the FEL light at the exit and inside of the undulator; electron beam micro-bunching using CTR; single-shot time resolved measurements of the pulse profile, using auto-correlation technique and FROG algorithm. The diagnostics are designed to provide maximum information on the physics of the SASE-FEL process, to ensure a close comparison of the experimental results with theory and simulations.

  1. Workshop on photon activation therapy: proceedings

    SciTech Connect

    Fairchild, R.G.

    1985-04-18

    This Workshop was held concurrently with an IAEA Research Coordination Meeting on Exploration of the Possibility of High-LET Radiation for Non-conventional Radiotherapy in Cancer. The Workshop on Photon Activation Therapy (PAT) was given as a special session on April 18, as it was thoght PAT might eventually be found to be attractive to developing countries, which is a major concern of the IAEA. An effort was made to bring together representatives of the various groups known to be actively working on PAT; these included investigators from Sweden and Japan as well as the US. It is hoped that this compendium of papers will be of use to those currently active in this developing field, as well as to those who might join this area of endeavor in the future.

  2. On bolus for megavoltage photon and electron radiation therapy

    SciTech Connect

    Vyas, Vedang; Palmer, Lisa; Mudge, Ray; Jiang, Runqing; Fleck, Andre; Schaly, Bryan; Osei, Ernest; Charland, Paule

    2013-10-01

    Frequently, in radiation therapy one must treat superficial lesions on cancer patients; these are at or adjacent to the skin. Megavoltage photon radiotherapy penetrates through the skin to irradiate deep-seated tumors, with skin-sparing property. Hence, to treat superficial lesions, one must use a layer of scattering material to feign as the skin surface. Although megavoltage electron beams are used for superficial treatments, one occasionally needs to enhance the dose near the surface. Such is the function of a “bolus,” a natural or synthetically developed material that acts as a layer of tissue to provide a more effective treatment to the superficial lesions. Other uses of boluses are to correct for varying surface contours and to add scattering material around the patient's surface. Materials used as bolus vary from simple water to metal and include various mixtures and compounds. Even with the modernization of the technology for external-beam therapy and the emergence of various commercial boluses, the preparation and utilization of a bolus in clinical radiotherapy remains an art. Considering the varying experiences and practices, this paper briefly summarizes available boluses that have been proposed and are employed in clinical radiotherapy. Although this review is not exhaustive, it provides some initial guidance and answers questions that may arise in clinical practice.

  3. Projection imaging of photon beams by the Cerenkov effect

    SciTech Connect

    Glaser, Adam K.; Davis, Scott C.; McClatchy, David M.; Zhang, Rongxiao; Pogue, Brian W.; Gladstone, David J.

    2013-01-15

    Purpose: A novel technique for beam profiling of megavoltage photon beams was investigated for the first time by capturing images of the induced Cerenkov emission in water, as a potential surrogate for the imparted dose in irradiated media. Methods: A high-sensitivity, intensified CCD camera (ICCD) was configured to acquire 2D projection images of Cerenkov emission from a 4 Multiplication-Sign 4 cm{sup 2} 6 MV linear accelerator (LINAC) x-ray photon beam operating at a dose rate of 400 MU/min incident on a water tank with transparent walls. The ICCD acquisition was gated to the LINAC sync pulse to reduce background light artifacts, and the measurement quality was investigated by evaluating the signal to noise ratio and measurement repeatability as a function of delivered dose. Monte Carlo simulations were used to derive a calibration factor for differences between the optical images and deposited dose arising from the anisotropic angular dependence of Cerenkov emission. Finally, Cerenkov-based beam profiles were compared to a percent depth dose (PDD) and lateral dose profile at a depth of d{sub max} from a reference dose distribution generated from the clinical Varian ECLIPSE treatment planning system (TPS). Results: The signal to noise ratio was found to be 20 at a delivered dose of 66.6 cGy, and proportional to the square root of the delivered dose as expected from Poisson photon counting statistics. A 2.1% mean standard deviation and 5.6% maximum variation in successive measurements were observed, and the Monte Carlo derived calibration factor resulted in Cerenkov emission images which were directly correlated to deposited dose, with some spatial issues. The dose difference between the TPS and PDD predicted by Cerenkov measurements was within 20% in the buildup region with a distance to agreement (DTA) of 1.5-2 mm and {+-}3% at depths beyond d{sub max}. In the lateral profile, the dose difference at the beam penumbra was within {+-}13% with a DTA of 0-2 mm

  4. New limits on hidden photons from past electron beam dumps

    NASA Astrophysics Data System (ADS)

    Andreas, Sarah; Niebuhr, Carsten; Ringwald, Andreas

    2012-11-01

    Hidden sectors with light extra U(1) gauge bosons, so-called hidden photons, have recently attracted some attention because they are a common feature of physics beyond the Standard Model like string theory and supersymmetry and additionally are phenomenologically of great interest regarding recent astrophysical observations. The hidden photon is already constrained by various laboratory experiments and presently searched for in running as well as upcoming experiments. We summarize the current status of limits on hidden photons from past electron beam dump experiments including two new limits from such experiments at the High Energy Accelerator Research Organization in Japan (KEK) and the Laboratoire de l’accelérateur linéaire (LAL, Orsay) that have so far not been considered. All our limits take into account the experimental acceptances obtained from Monte Carlo simulations.

  5. Scanned Carbon Pencil Beams for Tumor Therapy

    NASA Astrophysics Data System (ADS)

    Gemmel, A.; Saito, N.; Chaudhri, N.; Lü; chtenborg, R.; Schardt, D.; Rietzel, E.; Bert, Ch.

    2009-03-01

    At GSI a fully active beam application has been developed for tumor therapy with carbon ions. In this so-called rasterscan system the tumor volume is typically split into ˜60 slices of iso-energies taken from a list of 252 energies ranging from ˜90-430 MeV/u (range: 1.8-30.7 cm). The energies can be combined with variable beam diameters and intensities. For each iso-energy slice beam is requested from the synchrotron and delivered as a narrow pencil beam (beam's full width at half maximum 3-10 mm). For lateral target coverage this pencil beam is deflected to several hundreds of grid positions per iso-energy slice by orthogonal dipole magnets. At each grid position an optimized number of particles is deposited intensity-controlled, i.e. ionization chambers monitor the dose deposition and trigger deflection to the next grid position once the required dose level is achieved. This method allows intensity-modulated treatment fields necessary to deposit a uniform biological effective dose. Additionally, it allows for simultaneous optimization of multiple fields that allow better sparing of organs at risk partially or fully surrounded by the tumor. Scanned beam delivery facilitates target conformal and homogeneous dose delivery for stationary targets. For tumors located in the head & neck as well as tumors in the pelvic region very promising results were achieved in the carbon therapy pilot project started at GSI in 1993. A comparable project is conducted at Paul-Scherrer-Institut (PSI) in Switzerland with a scanned proton beam. One of the current research topics is the treatment of moving targets such as lung tumors. Scanned beam delivery requires but also offers possibilities to conformably irradiate moving target sites.

  6. Consistency check of photon beam physical data after recommissioning process

    NASA Astrophysics Data System (ADS)

    Kadman, B.; Chawapun, N.; Ua-apisitwong, S.; Asakit, T.; Chumpu, N.; Rueansri, J.

    2016-03-01

    In radiotherapy, medical linear accelerator (Linac) is the key system used for radiation treatments delivery. Although, recommissioning was recommended after major modification of the machine by AAPM TG53, but it might not be practical in radiotherapy center with heavy workloads. The main purpose of this study was to compare photon beam physical data between initial commissioning and recommissioning of 6 MV Elekta Precise linac. The parameters for comparing were the percentage depth dose (PDD) and beam profiles. The clinical commissioning test cases followed IAEA-TECDOC-1583 were planned on REF 91230 IMRT Dose Verification Phantom by Philips’ Pinnacle treatment planning system. The Delta4PT was used for dose distribution verification with 90% passing criteria of the gamma index (3%/3mm). Our results revealed that the PDDs and beam profiles agreed within a tolerance limit recommended by TRS430. Most of the point doses and dose distribution verification passed the acceptance criteria. This study showed the consistency of photon beam physical data after recommissioning process. There was a good agreement between initial commissioning and recommissioning within a tolerance limit, demonstrated that the full recommissioning process might not be required. However, in the complex treatment planning geometry, the initial data should be applied with great caution.

  7. Fan-beam intensity modulated proton therapy

    PubMed Central

    Hill, Patrick; Westerly, David; Mackie, Thomas

    2013-01-01

    Purpose: This paper presents a concept for a proton therapy system capable of delivering intensity modulated proton therapy using a fan beam of protons. This system would allow present and future gantry-based facilities to deliver state-of-the-art proton therapy with the greater normal tissue sparing made possible by intensity modulation techniques. Methods: A method for producing a divergent fan beam of protons using a pair of electromagnetic quadrupoles is described and particle transport through the quadrupole doublet is simulated using a commercially available software package. To manipulate the fan beam of protons, a modulation device is developed. This modulator inserts or retracts acrylic leaves of varying thickness from subsections of the fan beam. Each subsection, or beam channel, creates what effectively becomes a beam spot within the fan area. Each channel is able to provide 0–255 mm of range shift for its associated beam spot, or stop the beam and act as an intensity modulator. Results of particle transport simulations through the quadrupole system are incorporated into the MCNPX Monte Carlo transport code along with a model of the range and intensity modulation device. Several design parameters were investigated and optimized, culminating in the ability to create topotherapy treatment plans using distal-edge tracking on both phantom and patient datasets. Results: Beam transport calculations show that a pair of electromagnetic quadrupoles can be used to create a divergent fan beam of 200 MeV protons over a distance of 2.1 m. The quadrupole lengths were 30 and 48 cm, respectively, with transverse field gradients less than 20 T/m, which is within the range of water-cooled magnets for the quadrupole radii used. MCNPX simulations of topotherapy treatment plans suggest that, when using the distal edge tracking delivery method, many delivery angles are more important than insisting on narrow beam channel widths in order to obtain conformal target coverage

  8. Fan-beam intensity modulated proton therapy

    SciTech Connect

    Hill, Patrick; Westerly, David; Mackie, Thomas

    2013-11-15

    Purpose: This paper presents a concept for a proton therapy system capable of delivering intensity modulated proton therapy using a fan beam of protons. This system would allow present and future gantry-based facilities to deliver state-of-the-art proton therapy with the greater normal tissue sparing made possible by intensity modulation techniques.Methods: A method for producing a divergent fan beam of protons using a pair of electromagnetic quadrupoles is described and particle transport through the quadrupole doublet is simulated using a commercially available software package. To manipulate the fan beam of protons, a modulation device is developed. This modulator inserts or retracts acrylic leaves of varying thickness from subsections of the fan beam. Each subsection, or beam channel, creates what effectively becomes a beam spot within the fan area. Each channel is able to provide 0–255 mm of range shift for its associated beam spot, or stop the beam and act as an intensity modulator. Results of particle transport simulations through the quadrupole system are incorporated into the MCNPX Monte Carlo transport code along with a model of the range and intensity modulation device. Several design parameters were investigated and optimized, culminating in the ability to create topotherapy treatment plans using distal-edge tracking on both phantom and patient datasets.Results: Beam transport calculations show that a pair of electromagnetic quadrupoles can be used to create a divergent fan beam of 200 MeV protons over a distance of 2.1 m. The quadrupole lengths were 30 and 48 cm, respectively, with transverse field gradients less than 20 T/m, which is within the range of water-cooled magnets for the quadrupole radii used. MCNPX simulations of topotherapy treatment plans suggest that, when using the distal edge tracking delivery method, many delivery angles are more important than insisting on narrow beam channel widths in order to obtain conformal target coverage

  9. Intermediate Megavoltage Photon Beams for Improved Lung Cancer Treatments

    PubMed Central

    Zhang, Ying; Feng, Yuanming; Ahmad, Munir; Ming, Xin; Zhou, Li; Deng, Jun

    2015-01-01

    The goal of this study is to evaluate the effects of intermediate megavoltage (3-MV) photon beams on SBRT lung cancer treatments. To start with, a 3-MV virtual beam was commissioned on a commercial treatment planning system based on Monte Carlo simulations. Three optimized plans (6-MV, 3-MV and dual energy of 3- and 6-MV) were generated for 31 lung cancer patients with identical beam configuration and optimization constraints for each patient. Dosimetric metrics were evaluated and compared among the three plans. Overall, planned dose conformity was comparable among three plans for all 31 patients. For 21 thin patients with average short effective path length (< 10 cm), the 3-MV plans showed better target coverage and homogeneity with dose spillage index R50% = 4.68±0.83 and homogeneity index = 1.26±0.06, as compared to 4.95±1.01 and 1.31±0.08 in the 6-MV plans (p < 0.001). Correspondingly, the average/maximum reductions of lung volumes receiving 20 Gy (V20Gy), 5 Gy (V5Gy), and mean lung dose (MLD) were 7%/20%, 9%/30% and 5%/10%, respectively in the 3-MV plans (p < 0.05). The doses to 5% volumes of the cord, esophagus, trachea and heart were reduced by 9.0%, 10.6%, 11.4% and 7.4%, respectively (p < 0.05). For 10 thick patients, dual energy plans can bring dosimetric benefits with comparable target coverage, integral dose and reduced dose to the critical structures, as compared to the 6-MV plans. In conclusion, our study indicated that 3-MV photon beams have potential dosimetric benefits in treating lung tumors in terms of improved tumor coverage and reduced doses to the adjacent critical structures, in comparison to 6-MV photon beams. Intermediate megavoltage photon beams (< 6-MV) may be considered and added into current treatment approaches to reduce the adjacent normal tissue doses while maintaining sufficient tumor dose coverage in lung cancer radiotherapy. PMID:26672752

  10. Matching of electron and photon beams with a multi-leaf collimator.

    PubMed

    Karlsson, M; Zackrisson, B

    1993-12-01

    Multi-leaf collimators (MLCs) are offered as an accessory to many accelerators for radiation therapy. However, beam edges generated with these collimators are not as smooth as can be achieved with individually made blocks. The clinical drawbacks and benefits of this ripple were evaluated both for single field treatments and for combined adjacent fields of different beam qualities. In this investigation the MLC-collimated beams of the MM50 racetrack microtron were studied. The distance between the field edge and the 90% isodose was measured at the reference depth for four beam qualities (20 MV photons and 10, 20 and 50 MeV electrons). This distance was found to vary from approximately 6 mm for straight beam edges (i.e., all collimator leaves aligned) to approximately 2 mm from the tip of the leaves for a saw-tooth shaped beam edge. The over- and under-dosage in the joint between combined adjacent fields was found to be typically +/- 10% in small volumes. Improved clinical techniques using adjacent photon and electron fields with the same isocentre and source position (without moving the gantry) have been developed. For treatments of the breast, including the mammary chain, a uniform dose distribution was created with special attention given to the irradiation of the heart and lung outside the target volume. A method for head and neck treatments was optimised to give uniform dose distribution in the joint between the photon and electron fields and a method of treating the mediastinum, including the chest wall in front of the left lung, was analysed with respect to dose uniformity in the tumour and shielding of the lung.

  11. Photonic metallic nanostructures in photodynamic therapy

    NASA Astrophysics Data System (ADS)

    Ion, Rodica-Mariana; Fierascu, R. C.; Dumitriu, Irina

    2009-01-01

    Plasmons are resonant modes that involve the interaction between free charges and light. Nanoparticle-based photonic explorers have been developed for photodynamic therapy (PDT). PDT has been widely used in both oncological (e.g., tumors) and nononcological (e.g., age-related macular degeneration, localized infection, and nonmalignant skin conditions) applications. Three primary components are involved in PDT: light, a photosensitizing drug, and oxygen. The photosensitizer adsorbs light energy, which it then transfers to molecular oxygen to create an activated form of oxygen called singlet oxygen. The singlet oxygen is a cytotoxic agent and reacts rapidly with cellular components to cause damage that ultimately leads to cell death and tumor destruction. The changed topography of the film surface after deposition is caused by a local material transport and a material separation between formed particles (probably AgNO3) and an embedding polymer matrix as chitosan. This paper focuses on the current use of injectable in situ Au/(Ag)/chitosan hydrogels in cancer photodynamic treatment. Formulation protocols for their cytotoxic properties, their effect on cell growth in vitro and inhibition of tumor growth in vivo using mouse models, are discussed.

  12. Deconfinement of Quarks with TeV Attosecond Photon Beams

    NASA Astrophysics Data System (ADS)

    Stefan, V. Alexander

    2010-02-01

    Recently, I have proposed a novel heuristic method for the deconfinement of quarks.footnotetextM. Gell-Mann. The Quark and the Jaguar: Adventures in the Simple and the Complex (New York, NY: W.H. Freeman and Co., 1994) [cf. M. Gell-Mann, The Garden of Live Flowers in: V. Stefan (Editor), Physics and Society. Essays Honoring Victor Frederick Weisskopf (Springer, 1998), pp. 109-121]. It proceeds in two phases.footnotetextV. Alexander Stefan, On a Heuristic Point of View About Inertial Deconfinement of Quarks, American Physical Society, 2009 APS April Meeting, May 2-5, 2009, abstract #E1.038. Firstly, a frozen hydrogen pellet is inertially confined by the ultra-intense lasers up to a solid state density. Secondly, a solid state nano-pellet is ``punched'' by the photon beam created in the beat wave driven free electron laser (BW-FEL), leading to the ``rapture'' (in a ``karate chop'' model) of the ``MIT Bag''footnotetextJ. I. Friedman and H. Kendall, Viki, in: V. Stefan (Editor), Physics and Society. (Springer, 1998), pp. 103-108]. before the asymptotically free quarks move apart. Hereby, I propose TeV, a few 100s attosecond, photon beams in interaction with the nano-pellet. The threshold ``rapture force'' of the TeV attosecond photon is 10^7 N. )

  13. Secondary Neutron Doses for Several Beam Configurations for Proton Therapy

    SciTech Connect

    Shin, Dongho; Yoon, Myonggeun; Kwak, Jungwon; Shin, Jungwook; Lee, Se Byeong Park, Sung Yong; Park, Soah; Kim, Dae Yong; Cho, Kwan Ho

    2009-05-01

    Purpose: To compare possible neutron doses produced in scanning and scattering modes, with the latter assessed using a newly built passive-scattering proton beam line. Methods and Materials: A 40 x 30.5 x 30-cm water phantom was irradiated with 230-MeV proton beams using a gantry angle of 270{sup o}, a 10-cm-diameter snout, and a brass aperture with a diameter of 7 cm and a thickness of 6.5 cm. The secondary neutron doses during irradiation were measured at various points using CR-39 detectors, and these measurements were cross-checked using a neutron survey meter with a 22-cm range and a 5-cm spread-out Bragg peak. Results: The maximum doses due to secondary neutrons produced by a scattering beam-delivery system were on the order of 0.152 mSv/Gy and 1.17 mSv/Gy at 50 cm from the beam isocenter in the longitudinal (0{sup o}) and perpendicular (90{sup o}) directions, respectively. The neutron dose equivalent to the proton absorbed dose, measured from 10 cm to 100 cm from the isocenter, ranged from 0.071 mSv/Gy to 1.96 mSv/Gy in the direction of the beam line (i.e., {phi} = 0 deg.). The largest neutron dose, of 3.88 mSv/Gy, was observed at 135{sup o} and 25 cm from the isocenter. Conclusions: Although the secondary neutron doses in proton therapy were higher when a scattering mode rather than a scanning mode was used, they did not exceed the scattered photon dose in typical photon treatments.

  14. Beam alignment test for therapy accelerators

    SciTech Connect

    Lutz, W.R.; Larsen, R.D.; Bjarngard, B.D.

    1981-12-01

    Beam spot displacement, collimator asymmetry, and movement of either collimator or gantry rotational axis can cause misalignment of the X ray beam from a therapy accelerator. A test method, sensitive to all the above problems, consists of double-exposing a film, located at the isocenter, for two gantry positions, 180/sup o/ apart. Opposite halves of the field are blocked for each exposure. A lateral shift of one half with respect to the other indicates the presence of one of the problems mentioned above. Additional tests are described, each of which is sensitive to only one of the problems and capable of quantifying the error.

  15. Beam alignment tests for therapy accelerators

    SciTech Connect

    Lutz, W.R.; Larsen, R.D.; Bjarngard, B.E.

    1981-12-01

    Beam spot displacement, collimator asymmetry, and movement of either collimator or gantry rotational axis can cause misalignment of the X ray beam from a therapy accelerator. A test method, sensitive to all the above problems, consists of double-exposing a film, located at the isocenter, for two gantry positions, 180/sup 0/ apart. Opposite halves of the field are blocked for each exposure. A lateral shift of one half with respect to the other indicates the presence of one of the problems mentioned above. Additional tests are described, each of which is sensitive to only one of the problems and capable of quantifying the error.

  16. Mechanically tunable photonic crystal split-beam nanocavity

    NASA Astrophysics Data System (ADS)

    Lin, Tong; Zou, Yongchao; Zhou, Guangya; Chau, Fook Siong; Deng, Jie

    2016-03-01

    Photonic crystal split-beam nanocavities allow for ultra-sensitive optomechanical transductions but are degraded due to their relatively low optical quality factors. We report our recent work in designing a new type of one-dimensional photonic crystal split-beam nanocavity optimized for an ultra-high optical quality factor. The design is based on the combination of the deterministic method and hill-climbing algorithm. The latter is the simplest and most straightforward method of the local search algorithm, which provides the local maximum of the chosen quality factors. This split-beam nanocavity is made up of two mechanical uncoupled cantilever beams with Bragg mirrors patterned onto it and separated by a 75 nm air gap. Experimental results emphasize that the quality factor of the second order TE mode can be as high as 19,900. Additionally, one beam of the device is actuated in the lateral direction with the aid of a NEMS actuator and the quality factor maintains quite well even there's a lateral offset up to 64 nm. We also apply Fano resonance to further increase the Q-factor by constructing two interfering channels. Before tuning, the original Q-factor is 60,000; it's noteworthy that the topmost Q-factor reaches 67,000 throughout out-of-plane electrostatic force tuning. The dynamic mechanical modes of two devices is analyzed as well. Potentially promising applications, such as ultra-sensitive optomechanical torque sensor, local tuning of fano resonance, all-optical-reconfigurable filters etc, are foreseen.

  17. Characterization of electron contamination in megavoltage photon beams

    SciTech Connect

    Medina, Antonio Lopez; Teijeiro, Antonio; Garcia, Juan; Esperon, Jorge; Terron, J. Antonio; Ruiz, Diego P.; Carrion, Maria C.

    2005-05-01

    The purpose of the present study is to characterize electron contamination in photon beams in different clinical situations. Variations with field size, beam modifier (tray, shaping block) and source-surface distance (SSD) were studied. Percentage depth dose measurements with and without a purging magnet and replacing the air by helium were performed to identify the two electron sources that are clearly differentiated: air and treatment head. Previous analytical methods were used to fit the measured data, exploring the validity of these models. Electrons generated in the treatment head are more energetic and more important for larger field sizes, shorter SSD, and greater depths. This difference is much more noticeable for the 18 MV beam than for the 6 MV beam. If a tray is used as beam modifier, electron contamination increases, but the energy of these electrons is similar to that of electrons coming from the treatment head. Electron contamination could be fitted to a modified exponential curve. For machine modeling in a treatment planning system, setting SSD at 90 cm for input data could reduce errors for most isocentric treatments, because they will be delivered for SSD ranging from 80 to 100 cm. For very small field sizes, air-generated electrons must be considered independently, because of their different energetic spectrum and dosimetric influence.

  18. Characterization of electron contamination in megavoltage photon beams.

    PubMed

    Lopez Medina, Antonio; Teijeiro, Antonio; Garcia, Juan; Esperon, Jorge; Terron, J Antonio; Ruiz, Diego P; Carrion, Maria C

    2005-05-01

    The purpose of the present study is to characterize electron contamination in photon beams in different clinical situations. Variations with field size, beam modifier (tray, shaping block) and source-surface distance (SSD) were studied. Percentage depth dose measurements with and without a purging magnet and replacing the air by helium were performed to identify the two electron sources that are clearly differentiated: air and treatment head. Previous analytical methods were used to fit the measured data, exploring the validity of these models. Electrons generated in the treatment head are more energetic and more important for larger field sizes, shorter SSD, and greater depths. This difference is much more noticeable for the 18 MV beam than for the 6 MV beam. If a tray is used as beam modifier, electron contamination increases, but the energy of these electrons is similar to that of electrons coming from the treatment head. Electron contamination could be fitted to a modified exponential curve. For machine modeling in a treatment planning system, setting SSD at 90 cm for input data could reduce errors for most isocentric treatments, because they will be delivered for SSD ranging from 80 to 100 cm. For very small field sizes, air-generated electrons must be considered independently, because of their different energetic spectrum and dosimetric influence.

  19. Cardiac single-photon emission-computed tomography using combinedcone-beam/fan-beam collimation

    SciTech Connect

    Gullberg, Grant T.; Zeng, Gengsheng L.

    2004-12-03

    The objective of this work is to increase system sensitivity in cardiac single-photon emission-computed tomography (SPECT) studies without increasing patient imaging time. For imaging the heart, convergent collimation offers the potential of increased sensitivity over that of parallel-hole collimation. However, if a cone-beam collimated gamma camera is rotated in a planar orbit, the projection data obtained are not complete. Two cone-beam collimators and one fan-beam collimator are used with a three-detector SPECT system. The combined cone-beam/fan-beam collimation provides a complete set of data for image reconstruction. The imaging geometry is evaluated using data acquired from phantom and patient studies. For the Jaszazck cardiac torso phantom experiment, the combined cone-beam/fan-beam collimation provided 1.7 times greater sensitivity than standard parallel-hole collimation (low-energy high-resolution collimators). Also, phantom and patient comparison studies showed improved image quality. The combined cone-beam/fan-beam imaging geometry with appropriate weighting of the two data sets provides improved system sensitivity while measuring sufficient data for artifact free cardiac images.

  20. Multi-photon resonance phenomena using Laguerre-Gaussian beams

    NASA Astrophysics Data System (ADS)

    Hamideh Kazemi, Seyedeh; Mahmoudi, Mohammad

    2016-12-01

    We study the influence of laser profile on the linewidth of the optical spectrum of multi-photon resonance phenomena. First, we investigate the dependence of the absorption spectrum on the laser profile in a two-level system. Thanks to the Laguerre-Gaussian field, the linewidth of the one-photon optical pumping and two-photon absorption peaks are explicitly narrower than that obtained with a Gaussian field. In the next section, it is shown that, compared to the Gaussian fields, the Laguerre-Gaussian ones reduce the linewidth of the optical spectrum in the coherent population trapping. Interestingly, it turns out that the use of a Laguerre-Gaussian beam makes the linewidth of the spectrum narrower as compared with a Gaussian one in Doppler-broadened electromagnetically induced transparency. Moreover, we study the effect of the laser profile on the Autler-Townes doublet structure in the absorption spectrum for a laser-driven four-level atomic system. We also consider the different values of the Laguerre-Gaussian mode beam waist, and, perhaps more remarkably, we find that for the small waist values, the Autler-Townes doublet can be removed and a prominent narrow central peak appears in the absorption spectrum. Finally, we investigate the effect of the laser profile on the linewidth of the sub-natural three-photon absorption peak of double dark resonance. The differences in the linewidth are quite large, offering potential applications in metrology and isotope separation methods. Our results can be used for super ultra-high resolution laser spectroscopy and to improve the resolution of the technology of isotope/isomer separation and photo-biology even at essential overlap of the spectra of the different particles.

  1. Use of flattening filter-free photon beams in treating medulloblastoma: a dosimetric evaluation.

    PubMed

    Anchineyan, Pichandi; Mani, Ganesh K; Amalraj, Jerrin; Karthik, Balaji; Anbumani, Surega

    2014-01-01

    Aim. To evaluate the dosimetric benefits of flattening filter-free (FFF) photon beams in intensity modulated radiation therapy (IMRT) and Rapid Arc (RA) over conventional CSI methods. Methods and Materials. Five patients treated with IMRT using static multileaf collimators (MLC) were randomly selected for this retrospective study. Dynamic MLC IMRT, RA, and conformal therapy (3DCRT) were iterated with the same CT data sets with and without flattening filter photons. Total dose prescribed was 28.80 Gy in 16 fractions. Dosimetric parameters such as D max⁡, D min⁡, D mean, V 95%, V 107%, DHI, and CI for PTV and D max⁡, D mean, V 80%, V 50%, V 30%, and V 10% for OARs were extracted from DVHs. Beam on time (BOT) for various plans was also compared. Results. FFF RA therapy (6F_RA) resulted in highly homogeneous and conformal doses throughout the craniospinal axis. 3DCRT resulted in the highest V 107% (SD) 46.97 ± 28.6, whereas flattening filter (FF) and FFF dynamic IMRT had a minimum V 107%. 6F_RA and 6F_DMLC resulted in lesser doses to thyroid, eyes, esophagus, liver, lungs, and kidneys. Conclusion. FFF IMRT and FFF RA for CSI have definite dosimetric advantages over 3DCRT technique in terms of target coverage and OAR sparing. Use of FFF in IMRT resulted in 50% reduction in BOT, thereby increasing the treatment efficiency.

  2. Packaging consideration of two-dimensional polymer-based photonic crystals for laser beam steering

    NASA Astrophysics Data System (ADS)

    Dou, Xinyuan; Chen, Xiaonan; Chen, Maggie Yihong; Wang, Alan Xiaolong; Jiang, Wei; Chen, Ray T.

    2009-02-01

    In this paper, we report the theoretical study of polymer-based photonic crystals for laser beam steering which is based on the superprism effect as well as the experiment fabrication of the two dimensional photonic crystals for the laser beam steering. Superprism effect, the principle for beam steering, was separately studied in details through EFC (Equifrequency Contour) analysis. Polymer based photonic crystals were fabricated through double exposure holographic interference method using SU8-2007. The experiment results were also reported.

  3. Proton-beam therapy for prostate cancer.

    PubMed

    Kagan, A Robert; Schulz, Robert J

    2010-01-01

    The treatment options for prostate cancer include prostatectomy, external-beam irradiation, brachytherapy, cryosurgery, focused ultrasound, hormonal therapy, watchful waiting, and various combinations of these modalities. Because the prostate abuts the bladder and rectum, the dose distributions of external-beam irradiations and the accuracy of their placement play crucial roles in the probability of tumor cure and the incidence of posttreatment complications. Principal among the newer radiation technologies is proton-beam therapy (PBT), whose dose distributions make it possible to deliver higher tumor doses and smaller doses to surrounding normal tissues than from x-ray systems. However, as the 10-year cause-specific survival for early-stage disease treated by radiation therapy now exceeds 90%, and with severe late toxicities in the range of 2% to 3%, randomized clinical trials provide the only means to demonstrate improved outcomes from PBT. Short of the data provided by such trials, the efficacy of PBT can be gleaned only from reports in the clinical literature, and, to date, these reports are equivocal. In view of the current health care crisis and the higher costs of PBT for prostate cancer, it is reasonable to assess the viability of this in-vogue but not-so-new technology.

  4. Repeated proton beam therapy for hepatocellular carcinoma

    SciTech Connect

    Hashimoto, Takayuki |. E-mail: hashimoto@pmrc.tsukuba.ac.jp; Tokuuye, Koichi |; Fukumitsu, Nobuyoshi |; Igaki, Hiroshi |; Hata, Masaharu |; Kagei, Kenji |; Sugahara, Shinji; Ohara, Kiyoshi; Matsuzaki, Yasushi; Akine, Yasuyuki |

    2006-05-01

    Purpose: To retrospectively evaluate the safety and effectiveness of repeated proton beam therapy for newly developed or recurrent hepatocellular carcinoma (HCC). Methods and Materials: From June 1989 through July 2000, 225 patients with HCC underwent their first course of proton beam therapy at University of Tsukuba. Of them, 27 with 68 lesions who had undergone two or more courses were retrospectively reviewed in this study. Median interval between the first and second course was 24.5 months (range 3.3-79.8 months). Median total dose of 72 Gy in 16 fractions and 66 Gy in 16 fractions were given for the first course and the rest of the courses, respectively. Results: The 5-year survival rate and median survival period from the beginning of the first course for the 27 patients were 55.6% and 62.2 months, respectively. Five-year local control rate for the 68 lesions was 87.8%. Of the patients, 1 with Child-Pugh class B and another with class C before the last course suffered from acute hepatic failure. Conclusions: Repeated proton beam therapy for HCC is safe when the patient has a target in the peripheral region of the liver and liver function is Child-Pugh class A.

  5. Reduction of metal artifacts: beam hardening and photon starvation effects

    NASA Astrophysics Data System (ADS)

    Yadava, Girijesh K.; Pal, Debashish; Hsieh, Jiang

    2014-03-01

    The presence of metal-artifacts in CT imaging can obscure relevant anatomy and interfere with disease diagnosis. The cause and occurrence of metal-artifacts are primarily due to beam hardening, scatter, partial volume and photon starvation; however, the contribution to the artifacts from each of them depends on the type of hardware. A comparison of CT images obtained with different metallic hardware in various applications, along with acquisition and reconstruction parameters, helps understand methods for reducing or overcoming such artifacts. In this work, a metal beam hardening correction (BHC) and a projection-completion based metal artifact reduction (MAR) algorithms were developed, and applied on phantom and clinical CT scans with various metallic implants. Stainless-steel and Titanium were used to model and correct for metal beam hardening effect. In the MAR algorithm, the corrupted projection samples are replaced by the combination of original projections and in-painted data obtained by forward projecting a prior image. The data included spine fixation screws, hip-implants, dental-filling, and body extremity fixations, covering range of clinically used metal implants. Comparison of BHC and MAR on different metallic implants was used to characterize dominant source of the artifacts, and conceivable methods to overcome those. Results of the study indicate that beam hardening could be a dominant source of artifact in many spine and extremity fixations, whereas dental and hip implants could be dominant source of photon starvation. The BHC algorithm could significantly improve image quality in CT scans with metallic screws, whereas MAR algorithm could alleviate artifacts in hip-implants and dentalfillings.

  6. Detector dose response in megavoltage small photon beams. II. Pencil beam perturbation effects

    SciTech Connect

    Bouchard, Hugo Duane, Simon; Kamio, Yuji; Palmans, Hugo; Seuntjens, Jan

    2015-10-15

    Purpose: To quantify detector perturbation effects in megavoltage small photon fields and support the theoretical explanation on the nature of quality correction factors in these conditions. Methods: In this second paper, a modern approach to radiation dosimetry is defined for any detector and applied to small photon fields. Fano’s theorem is adapted in the form of a cavity theory and applied in the context of nonstandard beams to express four main effects in the form of perturbation factors. The pencil-beam decomposition method is detailed and adapted to the calculation of perturbation factors and quality correction factors. The approach defines a perturbation function which, for a given field size or beam modulation, entirely determines these dosimetric factors. Monte Carlo calculations are performed in different cavity sizes for different detection materials, electron densities, and extracameral components. Results: Perturbation effects are detailed with calculated perturbation functions, showing the relative magnitude of the effects as well as the geometrical extent to which collimating or modulating the beam impacts the dosimetric factors. The existence of a perturbation zone around the detector cavity is demonstrated and the approach is discussed and linked to previous approaches in the literature to determine critical field sizes. Conclusions: Monte Carlo simulations are valuable to describe pencil beam perturbation effects and detail the nature of dosimetric factors in megavoltage small photon fields. In practice, it is shown that dosimetric factors could be avoided if the field size remains larger than the detector perturbation zone. However, given a detector and beam quality, a full account for the detector geometry is necessary to determine critical field sizes.

  7. Interferometric source of multi-color, multi-beam entangled photons with mirror and mixer

    DOEpatents

    Dress, William B.; Kisner, Roger A.; Richards, Roger K.

    2004-06-01

    53 Systems and methods are described for an interferometric source of multi-color, multi-beam entangled photons. An apparatus includes: a multi-refringent device optically coupled to a source of coherent energy, the multi-refringent device providing a beam of multi-color entangled photons; a condenser device optically coupled to the multi-refringent device, the condenser device i) including a mirror and a mixer and ii) converging two spatially resolved portions of the beam of multi-color entangled photons into a converged multi-color entangled photon beam; a tunable phase adjuster optically coupled to the condenser device, the tunable phase adjuster changing a phase of at least a portion of the converged multi-color entangled photon beam to generate a first interferometeric multi-color entangled photon beam; and a beam splitter optically coupled to the condenser device, the beam splitter combining the first interferometeric multi-color entangled photon beam with a second interferometric multi-color entangled photon beam.

  8. Forked grating coupler optical vortex beam interface for silicon photonics

    NASA Astrophysics Data System (ADS)

    Nadovich, Christopher T.; Kosciolek, Derek J.; Jemison, William D.; Crouse, David T.

    2016-09-01

    The forked grating coupler (FGC) is a novel low-profile device compatible with silicon photonics that is capable of sensitive detection or efficient radiation of Optical Vortex (OV) light beams conveying orbital optical angular momentum (OAM). The FGC device combines the idea of a Bragg coupler with the forked hologram to create an integrated optics device that can selectively and efficiently couple selected optical vortex modes at near-normal incidence into planar confined dielectric waveguide modes of a photonic IC. FGCs retain many of the advantages of Bragg couplers, including convenience of placement and fabrication, reasonable bandwidth, small size, and CMOS process compatibility. In this work, prototype designs of FGC structures for 1550 nm wavelength have been developed for implementation on silicon on insulator (SOI) substrate. Fully vectorial three-dimensional (3D) electromagnetic simulation has allowed performance to be optimized over a range of structural parameters. Results have been evaluated against optical performance metrics including overall efficiency, mode match efficiency, and crosstalk between OV modes. Candidate FGC devices have been fabricated on SOI with e-beam lithography and tested optically. Tolerance to etch depth error has been evaluated.

  9. Proton-Beam Therapy for Olfactory Neuroblastoma

    SciTech Connect

    Nishimura, Hideki . E-mail: westvill@med.kobe-u.ac.jp; Ogino, Takashi; Kawashima, Mitsuhiko; Nihei, Keiji; Arahira, Satoko; Onozawa, Masakatsu; Katsuta, Shoichi; Nishio, Teiji

    2007-07-01

    Purpose: To analyze the feasibility and efficacy of proton-beam therapy (PBT) for olfactory neuroblastoma (ONB) as a definitive treatment, by reviewing our preliminary experience. Olfactory neuroblastoma is a rare disease, and a standard treatment strategy has not been established. Radiation therapy for ONB is challenging because of the proximity of ONBs to critical organs. Proton-beam therapy can provide better dose distribution compared with X-ray irradiation because of its physical characteristics, and is deemed to be a feasible treatment modality. Methods and Materials: A retrospective review was performed on 14 patients who underwent PBT for ONB as definitive treatment at the National Cancer Center Hospital East (Kashiwa, Chiba, Japan) from November 1999 to February 2005. A total dose of PBT was 65 cobalt Gray equivalents (Gy{sub E}), with 2.5-Gy{sub E} once-daily fractionations. Results: The median follow-up period for surviving patients was 40 months. One patient died from disseminated disease. There were two persistent diseases, one of which was successfully salvaged with surgery. The 5-year overall survival rate was 93%, the 5-year local progression-free survival rate was 84%, and the 5-year relapse-free survival rate was 71%. Liquorrhea was observed in one patient with Kadish's stage C disease (widely destroying the skull base). Most patients experienced Grade 1 to 2 dermatitis in the acute phase. No other adverse events of Grade 3 or greater were observed according to the RTOG/EORTC acute and late morbidity scoring system. Conclusions: Our preliminary results of PBT for ONB achieved excellent local control and survival outcomes without serious adverse effects. Proton-beam therapy is considered a safe and effective modality that warrants further study.

  10. Design of a fast multileaf collimator for radiobiological optimized IMRT with scanned beams of photons, electrons, and light ions.

    PubMed

    Svensson, Roger; Larsson, Susanne; Gudowska, Irena; Holmberg, Rickard; Brahme, Anders

    2007-03-01

    Intensity modulated radiation therapy is rapidly becoming the treatment of choice for most tumors with respect to minimizing damage to the normal tissues and maximizing tumor control. Today, intensity modulated beams are most commonly delivered using segmental multileaf collimation, although an increasing number of radiation therapy departments are employing dynamic multileaf collimation. The irradiation time using dynamic multileaf collimation depends strongly on the nature of the desired dose distribution, and it is difficult to reduce this time to less than the sum of the irradiation times for all individual peak heights using dynamic leaf collimation [Svensson et al., Phys. Med. Biol. 39, 37-61 (1994)]. Therefore, the intensity modulation will considerably increase the total treatment time. A more cost-effective procedure for rapid intensity modulation is using narrow scanned photon, electron, and light ion beams in combination with fast multileaf collimator penumbra trimming. With this approach, the irradiation time is largely independent of the complexity of the desired intensity distribution and, in the case of photon beams, may even be shorter than with uniform beams. The intensity modulation is achieved primarily by scanning of a narrow elementary photon pencil beam generated by directing a narrow well focused high energy electron beam onto a thin bremsstrahlung target. In the present study, the design of a fast low-weight multileaf collimator that is capable of further sharpening the penumbra at the edge of the elementary scanned beam has been simulated, in order to minimize the dose or radiation response of healthy tissues. In the case of photon beams, such a multileaf collimator can be placed relatively close to the bremsstrahlung target to minimize its size. It can also be flat and thin, i.e., only 15-25 mm thick in the direction of the beam with edges made of tungsten or preferably osmium to optimize the sharpening of the penumbra. The low height of

  11. Design of a fast multileaf collimator for radiobiological optimized IMRT with scanned beams of photons, electrons, and light ions

    SciTech Connect

    Svensson, Roger; Larsson, Susanne; Gudowska, Irena; Holmberg, Rickard; Brahme, Anders

    2007-03-15

    Intensity modulated radiation therapy is rapidly becoming the treatment of choice for most tumors with respect to minimizing damage to the normal tissues and maximizing tumor control. Today, intensity modulated beams are most commonly delivered using segmental multileaf collimation, although an increasing number of radiation therapy departments are employing dynamic multileaf collimation. The irradiation time using dynamic multileaf collimation depends strongly on the nature of the desired dose distribution, and it is difficult to reduce this time to less than the sum of the irradiation times for all individual peak heights using dynamic leaf collimation [Svensson et al., Phys. Med. Biol. 39, 37-61 (1994)]. Therefore, the intensity modulation will considerably increase the total treatment time. A more cost-effective procedure for rapid intensity modulation is using narrow scanned photon, electron, and light ion beams in combination with fast multileaf collimator penumbra trimming. With this approach, the irradiation time is largely independent of the complexity of the desired intensity distribution and, in the case of photon beams, may even be shorter than with uniform beams. The intensity modulation is achieved primarily by scanning of a narrow elementary photon pencil beam generated by directing a narrow well focused high energy electron beam onto a thin bremsstrahlung target. In the present study, the design of a fast low-weight multileaf collimator that is capable of further sharpening the penumbra at the edge of the elementary scanned beam has been simulated, in order to minimize the dose or radiation response of healthy tissues. In the case of photon beams, such a multileaf collimator can be placed relatively close to the bremsstrahlung target to minimize its size. It can also be flat and thin, i.e., only 15-25 mm thick in the direction of the beam with edges made of tungsten or preferably osmium to optimize the sharpening of the penumbra. The low height of

  12. Sulfonated aluminum phthalocyanines for two-photon photodynamic cancer therapy: the effect of the excitation wavelength

    NASA Astrophysics Data System (ADS)

    Wang, J.; Li, W.; Yu, H. B.; Cheung, N. H.; Chen, J. Y.

    2014-03-01

    Sulfonated aluminum phthalocyanine (AlPcS) is a well-studied photosensitizer which has been widely used in research and in clinical applications of the photodynamic therapy of cancers. Conventionally, one-photon excitation was used, but it was unknown whether two-photon excitation of AlPcS was equally effective. In this study, the two-photon absorption cross sections of AlPcS at near infrared wavelengths were deduced from femtosecond (fs) laser-induced fluorescence. We found that the two-photon absorption cross section of AlPcS was strongly dependent on the excitation wavelength. It was about 19 GM when excited at 800 nm, but grew to 855 GM when excited at 750 nm. The 750 nm fs-laser-induced fluorescence images of AlPcS in human nasopharyngeal carcinoma cells were clearly visible while the corresponding images were very dim when excited at 800 nm. Singlet oxygen production was 13 times higher when excited at 750 nm relative to 800 nm. Our subsequent in vitro experiments showed that 750 nm two-photon excitation with an unfocused fs laser beam damaged cancer cells in a light-dose-dependent manner typical of photodynamic therapy (PDT). The killing at 750 nm was about 9-10 times more efficient than at 800 nm. These results demonstrated for the first time that AlPcS has good potential for two-photon PDT of cancers.

  13. Investigations of high mobility single crystal chemical vapor deposition diamond for radiotherapy photon beam monitoring

    SciTech Connect

    Tromson, D.; Descamps, C.; Tranchant, N.; Bergonzo, P.; Nesladek, M.; Isambert, A.

    2008-03-01

    The intrinsic properties of diamond make this material theoretically very suitable for applications in medical physics. Until now ionization chambers have been fabricated from natural stones and are commercialized by PTW, but their fairly high costs and long delivery times have often limited their use in hospital. The properties of commercialized intrinsic polycrystalline diamond were investigated in the past by many groups. The results were not completely satisfactory due to the nature of the polycrystalline material itself. In contrast, the recent progresses in the growth of high mobility single crystal synthetic diamonds prepared by chemical vapor deposition (CVD) technique offer new alternatives. In the framework of the MAESTRO project (Methods and Advanced Treatments and Simulations for Radio Oncology), the CEA-LIST is studying the potentialities of synthetic diamond for new techniques of irradiation such as intensity modulated radiation therapy. In this paper, we present the growth and characteristics of single crystal diamond prepared at CEA-LIST in the framework of the NoRHDia project (Novel Radiation Hard CVD Diamond Detector for Hadrons Physics), as well as the investigations of high mobility single crystal CVD diamond for radiotherapy photon beam monitoring: dosimetric analysis performed with the single crystal diamond detector in terms of stability and repeatability of the response signal, signal to noise ratio, response speed, linearity of the signal versus the absorbed dose, and dose rate. The measurements performed with photon beams using radiotherapy facilities demonstrate that single crystal CVD diamond is a good alternative for air ionization chambers for beam quality control.

  14. Neutron beam design, development, and performance for neutron capture therapy

    SciTech Connect

    Harling, O.K.; Bernard, J.A. ); Zamenhof, R.G. )

    1990-01-01

    The report presents topics presented at a workshop on neutron beams and neutron capture therapy. Topics include: neutron beam design; reactor-based neutron beams; accelerator-based neutron beams; and dosimetry and treatment planning. Individual projects are processed separately for the databases. (CBS)

  15. Simultaneous two-photon excitation of photodynamic therapy agents

    SciTech Connect

    Wachter, E.A.; Fisher, W.G. |; Partridge, W.P.; Dees, H.C.; Petersen, M.G.

    1998-01-01

    The spectroscopic and photochemical properties of several photosensitive compounds are compared using conventional single-photon excitation (SPE) and simultaneous two-photon excitation (TPE). TPE is achieved using a mode-locked titanium:sapphire laser, the near infrared output of which allows direct promotion of non-resonant TPE. Excitation spectra and excited state properties of both type 1 and type 2 photodynamic therapy (PDT) agents are examined.

  16. Rf-synchronized imaging for particle and photon beam characterizations

    SciTech Connect

    Lumpkin, A.H.

    1993-07-01

    The usefulness of imaging electro-optics for rf-driven accelerators can be enhanced by synchronizing the instruments to the system fundamental frequency or an appropriate subharmonic. This step allows one to obtain micropulse bunch length and phase during a series of linac bunches or storage ring passes. Several examples now exist of the use of synchroscan and dual-sweep streak cameras and/or image dissector tubes to access micropulse scale phenomena (10 to 30 ps) during linac and storage ring operations in the US, Japan, and Europe. As space permits, selections will be presented from the list of phase stability phenomena on photoelectric injectors, micropulse length during a macropulse, micropulse elongation effects, transverse Wakefield effects within a micropulse, and submicropulse phenomena on a stored beam. Potential applications to the subsystems of the Advanced Photon Source (APS) will be briefly addressed.

  17. A 4 MV flattening filter-free beam: commissioning and application to conformal therapy and volumetric modulated arc therapy

    NASA Astrophysics Data System (ADS)

    Stevens, S. W.; Rosser, K. E.; Bedford, J. L.

    2011-07-01

    Recent studies have indicated that radiotherapy treatments undertaken on a flattening filter-free (FFF) linear accelerator have a number of advantages over treatments undertaken on a conventional linear accelerator. In addition, 4 MV photon beams may give improved isodose coverage for some treatment volumes at air/tissue interfaces, compared to when utilizing the clinical standard of 6 MV photons. In order to investigate these benefits, FFF beams were established on an Elekta Beam Modulator linear accelerator for 4 MV photons. Commissioning beam data were obtained for open and wedged fields. The measured data were then imported into a treatment planning system and a beam model was commissioned. The beam model was optimized to improve dose calculations at shallow, clinically relevant depths. Following verification, the beam model was utilized in a treatment planning study, including volumetric modulated arc therapy, for a selection of lung, breast/chest wall and larynx patients. Increased dose rates of around 800 MU min-1 were recorded for open fields (relative to 320 MU min-1 for filtered open fields) and reduced head scatter was inferred from output factor measurements. Good agreement between planned and delivered dose was observed in verification of treatment plans. The planning study indicated that with a FFF beam, equivalent (and in some cases improved) isodose profiles could be achieved for small lung and larynx treatment volumes relative to 4 MV filtered treatments. Furthermore, FFF treatments with wedges could be replicated using open fields together with an 'effective wedge' technique and isocentre shift. Clinical feasibility of a FFF beam was therefore demonstrated, with beam modelling, treatment planning and verification being successfully accomplished.

  18. [Depth dose characteristics of photon beams released from a scanning-type racetrack microtron].

    PubMed

    Sato, Tomoharu

    2002-06-01

    The MM50 is a racetrack microtron that can emit photon beams or electron beams up to 50 MeV. The MM22 using the scanning beam method and the MM22 using a flattening filter method both to flatten the emission field and a water phantom with particular function measurable of PDD etc. in an accelerator using the scanning beam method to make up the PDD curve of photon beams from the linear accelerator. The Clinac21EX was thus employed. The maximum depth of beam flux was shallow, the gradient of the flux decrement large, the surface dose large, and the estimated nominal energy low to the same nominal energy. From these findings, it can be said that thorough comprehension of the characteristics of beam flux properties for these units is necessary when photon beams are to be used.

  19. On the conversion of infrared radiation from fission reactor-based photon engine into parallel beam

    NASA Astrophysics Data System (ADS)

    Gulevich, Andrey V.; Levchenko, Vladislav E.; Loginov, Nicolay I.; Kukharchuk, Oleg F.; Evtodiev, Denis A.; Zrodnikov, Anatoly V.

    2002-01-01

    The efficiency of infrared radiation conversion from photon engine based on fission reactor into parallel photon beam is discussed. Two different ways of doing that are considered. One of them is to use the parabolic mirror to convert of infrared radiation into parallel photon beam. The another one is based on the use of special lattice consisting of numerous light conductors. The experimental facility and some results are described. .

  20. THE PAIR BEAM PRODUCTION SPECTRUM FROM PHOTON-PHOTON ANNIHILATION IN COSMIC VOIDS

    SciTech Connect

    Schlickeiser, R.; Ibscher, D.; Elyiv, A.; Miniati, F. E-mail: ibscher@tp4.rub.de E-mail: fm@phys.ethz.ch

    2012-10-20

    Highly beamed relativistic e {sup {+-}}-pair energy distributions result in double photon collisions of the beamed gamma rays from TeV blazars at cosmological distances with the isotropically distributed extragalactic background light (EBL) in the intergalactic medium. The typical energies k {sub 0} {approx_equal} 10{sup -7} in units of m{sub e}c {sup 2} of the EBL are more than 10 orders of magnitude smaller than the observed gamma-ray energies k {sub 1} {>=} 10{sup 7}. Using the limit k {sub 0} << k {sub 1}, we demonstrate that the angular distribution of the generated pairs in the lab frame is highly beamed in the direction of the initial gamma-ray photons. For the astrophysically important case of power-law distributions of the emitted gamma-ray beam up to the maximum energy M interacting with Wien-type N(k {sub 0}){proportional_to}k{sup q} {sub 0}exp (- k {sub 0}/{Theta}) soft photon distributions with total number density N {sub 0}, we calculate analytical approximations for the electron production spectrum. For distant objects with luminosity distances d{sub L} >> r {sub 0} = ({sigma} {sub T} N {sub 0}){sup -1} = 0.49N {sup -1} {sub 0} Mpc (with Thomson cross section {sigma} {sub T}), the implied large values of the optical depth {tau}{sub 0} = d{sub L} /r {sub 0} indicate that the electron production spectra differ at energies inside and outside the interval [({Theta}ln {tau}{sub 0}){sup -1}, {tau}{sub 0}/{Theta}], given the maximum gamma-ray energy M >> {Theta}{sup -1}. In the case M >> {Theta}{sup -1}, the production spectrum is strongly peaked near E {approx_equal} {Theta}{sup -1}, being exponentially reduced at small energies and decreasing with the steep power law {proportional_to}E {sup -1-p} up to the maximum energy E = M - (1/2).

  1. Calculation of energy deposition, photon and neutron production in proton therapy of thyroid gland using MCNPX.

    PubMed

    Mowlavi, Ali Asghar; Fornasie, Maria Rosa; de Denaro, Mario

    2011-01-01

    In this study, the MCNPX code has been used to simulate a proton therapy in thyroid gland, in order to calculate the proton energy deposition in the target region. As well as, we have calculated the photon and neutron production spectra due to proton interactions with the tissue. We have considered all the layers of tissue, from the skin to the thyroid gland, and an incident high energy pencil proton beam. The results of the simulation show that the best proton energy interval, to cover completely the thyroid tissue, is from 42 to 54 MeV, assuming that the thyroid gland has a 14 mm thickness and is located 11.2mm under the skin surface. The most percentage of deposited energy (78%) is related to the 54 MeV proton energy beam. Total photon and neutron production are linear and polynomial second order functions of the proton energy, respectively.

  2. Photons for Therapy: Targeted Photodynamic Therapy for Infected and Contaminated Wounds

    DTIC Science & Technology

    2004-09-01

    RTO-MP-HFM-109 30 - 1 Photons for Therapy : Targeted Photodynamic Therapy for Infected and Contaminated Wounds Michael R Hamblin Faten Gad...unknown antibiotic susceptibility. Rationale: Previously workers have used photodynamic therapy to kill bacteria in vitro, but the use of this approach...play in preventing and treating infection in combat wounds. 1.0 INTRODUCTION Photodynamic therapy (PDT) is a therapy for cancer and other diseases

  3. Two-Photon-Absorption Scheme for Optical Beam Tracking

    NASA Technical Reports Server (NTRS)

    Ortiz, Gerardo G.; Farr, William H.

    2011-01-01

    A new optical beam tracking approach for free-space optical communication links using two-photon absorption (TPA) in a high-bandgap detector material was demonstrated. This tracking scheme is part of the canonical architecture described in the preceding article. TPA is used to track a long-wavelength transmit laser while direct absorption on the same sensor simultaneously tracks a shorter-wavelength beacon. The TPA responsivity was measured for silicon using a PIN photodiode at a laser beacon wavelength of 1,550 nm. As expected, the responsivity shows a linear dependence with incident power level. The responsivity slope is 4.5 x 10(exp -7) A/W2. Also, optical beam spots from the 1,550-nm laser beacon were characterized on commercial charge coupled device (CCD) and complementary metal-oxide semiconductor (CMOS) imagers with as little as 13.7 microWatts of optical power (see figure). This new tracker technology offers an innovative solution to reduce system complexity, improve transmit/receive isolation, improve optical efficiency, improve signal-to-noise ratio (SNR), and reduce cost for free-space optical communications transceivers.

  4. Beaming Properties of Energetic Electrons and Photons Inside Thunderstorms

    NASA Astrophysics Data System (ADS)

    Cramer, Eric; Briggs, Michael

    2017-01-01

    It has been well established that thunderstorm environments allow relativistic runaway electron avalanches (RREAs) to develop under the influence of strong electric fields. This process can be seeded by external sources, such as cosmic-ray secondary electrons. The resulting bremsstrahlung x-rays and gamma rays that are emitted, propagate through the atmosphere and into space where they are detected by orbiting spacecraft, e.g. NASA Fermi. These high energy radiation blasts are known as Terrestrial Gamma-ray Flashes (TGFs). Using a Monte Carlo particle simulation, we show beaming characteristics of these electrons and photons such as the angular distribution, energy spectra, and the radial distribution from the thunderstorm source to the observation point of orbiting spacecraft. These features are related to the thunderstorm electric field, Earth's geomagnetic field, and the potential inside the thundercloud region. Observations of TGFs made by the Gamma-ray Burst Monitor (GBM) will also be discussed, as well as a future multipoint CubeSat mission targeted to measure the beaming geometry of the gamma rays. This material is based upon work supported by the National Science Foundation under Grant Number 1524533.

  5. Asymmetric 2D spatial beam filtering by photonic crystals

    NASA Astrophysics Data System (ADS)

    Gailevicius, D.; Purlys, V.; Maigyte, L.; Gaizauskas, E.; Peckus, M.; Gadonas, R.; Staliunas, K.

    2016-04-01

    Spatial filtering techniques are important for improving the spatial quality of light beams. Photonic crystals (PhCs) with a selective spatial (angular) transmittance can also provide spatial filtering with the added benefit transversal symmetries, submillimeter dimensions and monolithic integration in other devices, such as micro-lasers or semiconductor lasers. Workable bandgap PhC configurations require a modulated refractive index with period lengths that are approximately less than the wavelength of radiation. This imposes technical limitations, whereby the available direct laser write (DLW) fabrication techniques are limited in resolution and refractive index depth. If, however, a deflection mechanism is chosen instead, a functional filter PhC can be produced that is operational in the visible wavelength regime. For deflection based PhCs glass is an attractive choice as it is highly stable medium. 2D and 3D PhC filter variations have already been produced on soda-lime glass. However, little is known about how to control the scattering of PhCs when approaching the smallest period values. Here we look into the internal structure of the initially symmetric geometry 2D PhCs and associating it with the resulting transmittance spectra. By varying the DLW fabrication beam parameters and scanning algorithms, we show that such PhCs contain layers that are comprised of semi-tilted structure voxels. We show the appearance of asymmetry can be compensated in order to circumvent some negative effects at the cost of potentially maximum scattering efficiency.

  6. Absolute calibration of photon-number-resolving detectors with an analog output using twin beams

    SciTech Connect

    Peřina, Jan; Haderka, Ondřej; Allevi, Alessia; Bondani, Maria

    2014-01-27

    A method for absolute calibration of a photon-number resolving detector producing analog signals as the output is developed using a twin beam. The method gives both analog-to-digital conversion parameters and quantum detection efficiency for the photon fields. Characteristics of the used twin beam are also obtained. A simplified variant of the method applicable to fields with high signal to noise ratios and suitable for more intense twin beams is suggested.

  7. Propagation behavior of incoherent beams in one-dimensional photonic crystals.

    PubMed

    Ding, Fei-Na; Chen, Yuan-Yuan; Shi, Jie-Long

    2010-03-01

    The propagation properties of Gaussian Schell-model spatially incoherent beams through a one-dimensional photonic crystal (1DPC) are investigated. The dynamical evolution of incoherent beams in 1DPC and the Goos-Hänchen lateral shift of the transmitted beams are obtained. The mutual effects of coherence and bandgap of the PC on the evolution of incoherent beams are analyzed. The incidence angle of the incoherent beam also has an influence on the incoherent electric field and the lateral shift.

  8. Fast optimization and dose calculation in scanned ion beam therapy

    SciTech Connect

    Hild, S.; Graeff, C.; Trautmann, J.; Kraemer, M.; Zink, K.; Durante, M.; Bert, C.

    2014-07-15

    Purpose: Particle therapy (PT) has advantages over photon irradiation on static tumors. An increased biological effectiveness and active target conformal dose shaping are strong arguments for PT. However, the sensitivity to changes of internal geometry complicates the use of PT for moving organs. In case of interfractionally moving objects adaptive radiotherapy (ART) concepts known from intensity modulated radiotherapy (IMRT) can be adopted for PT treatments. One ART strategy is to optimize a new treatment plan based on daily image data directly before a radiation fraction is delivered [treatment replanning (TRP)]. Optimizing treatment plans for PT using a scanned beam is a time consuming problem especially for particles other than protons where the biological effective dose has to be calculated. For the purpose of TRP, fast optimization and fast dose calculation have been implemented into the GSI in-house treatment planning system (TPS) TRiP98. Methods: This work reports about the outcome of a code analysis that resulted in optimization of the calculation processes as well as implementation of routines supporting parallel execution of the code. To benchmark the new features, the calculation time for therapy treatment planning has been studied. Results: Compared to the original version of the TPS, calculation times for treatment planning (optimization and dose calculation) have been improved by a factor of 10 with code optimization. The parallelization of the TPS resulted in a speedup factor of 12 and 5.5 for the original version and the code optimized version, respectively. Hence the total speedup of the new implementation of the authors' TPS yielded speedup factors up to 55. Conclusions: The improved TPS is capable of completing treatment planning for ion beam therapy of a prostate irradiation considering organs at risk in this has been overseen in the review process. Also see below 6 min.

  9. SU-E-T-796: Variation of Surface Photon Energy Spectra On Bone Heterogeneity and Beam Obliquity Between Flattened and Unflattened Beam

    SciTech Connect

    Chow, J; Owrangi, A; Grigorov, G

    2015-06-15

    Purpose: This study investigates the spectra of surface photon energy and energy fluence in the bone heterogeneity and beam obliquity using flattened and unflattened photon beams. The spectra were calculated in a bone and water phantom using Monte Carlo simulation (the EGSnrc code). Methods: Spectra of energy, energy fluence and mean energy of the 6 MV flattened and unflattened photon beams (field size = 10 × 10 cm{sup 2}) produced by a Varian TrueBEAM linear accelerator were calculated at the surfaces of a bone and water phantom using Monte Carlo simulations. The spectral calculations were repeated with the beam angles turned from 0° to 15°, 30° and 45° in the phantoms. Results: It is found that the unflattened photon beams contained more photons in the low-energy range of 0 – 2 MeV than the flattened beams with a flattening filter. Compared to the water phantom, both the flattened and unflattened beams had slightly less photons in the energy range < 0.4 MeV when a bone layer of 1 cm is present under the phantom surface. This shows that the presence of the bone decreased the low-energy photons backscattered to the phantom surface. When the photon beams were rotated from 0° to 45°, the number of photon and mean photon energy increased with the beam angle. This is because both the flattened and unflattened beams became more hardened when the beam angle increased. With the bone heterogeneity, the mean energies of both photon beams increased correspondingly. This is due to the absorption of low-energy photons by the bone, resulting in more significant beam hardening. Conclusion: The photon spectral information is important in studies on the patient’s surface dose enhancement when using unflattened photon beams in radiotherapy.

  10. Poster — Thur Eve — 37: Respiratory gating with an Elekta flattening filter free photon beam

    SciTech Connect

    Péloquin, S; Furstoss, C; Munger, P; Wierzbicki, W; Carrier, J-F

    2014-08-15

    In cases where surgery is not possible for lung cancer treatment, stereotactic body radiation therapy (SBRT) may be an option. One problem when treating this type of cancer is the motion of the lungs caused by the patient's respiration. It is possible to reduce the impact of this movement with the use of respiratory gating. By combining respiratory gating with a flattening filter free (FFF) photon beam linac, the increased treatment time caused by a reduced beam-on time of respiratory gating methods can be compensated by the inherent increased dose rate of FFF beams. This project's aim is to create hardware and software interfaces allowing free respiration gating on an Elekta Synergy-S linac specially modified to deliver 6 MV FFF photon beams. First, a printed circuit board was created for reading the signal from a Bellows Belt from Philips (a respiration monitor belt) and transmitting an On/Off signal to the accelerator. A software was also developed to visualize patient respiration. Secondly, a FFF model was created with the Pinnacle treatment planning system from Philips. Gamma (Γ) analysis (2%, 2 mm) was used to evaluate model. For fields going from 5.6 × 5.6 to 12 × 12 cm{sup 2}, central axis depth dose model fitting shows an average gamma value of 0.2 and 100% of gamma values remain under the Γ = 1 limit. For smaller fields (0.8 × 0.8 and 1.6 × 1.6 cm{sup 2}), Pinnacle has more trouble trying to fit the measurements, overestimating dose in penumbra and buildup regions.

  11. Proton and photon beams interaction with radiosensitizing agents in human glioblastoma cells

    NASA Astrophysics Data System (ADS)

    Lafiandra, M.

    2016-03-01

    In oncological field, chemoradiotherapy treatments that combine radiations to radiosensitizing chemical agents are spreading out. The aim of this kind of treatment is to obtain a better tumor local control and at the same time to reduce the distant failure. The combination of radiation with microtubule-stabilizing agents is very promising in cancer therapy. In the present study, the combination of clinical proton beams and the microtubule-stabilizing agent Epothilone B has been investigated in human glioblastoma cells cultured in vitro. Photon beams have been used for comparison. Cell survival has been evaluated by colony forming assay and the interaction mechanism between radiation and Epothilone B has been investigated: survival curves relative to the combined treatment (protons or photons with Epothilone B) showed a linear trend, different from the linear quadratic behavior found with radiation alone. The analysis performed showed a synergism in the radiation-drug interaction. Thus, Epothilone B in conjunction with radiation acts as a radiosensitizer. Finally proton Relative Biological Effectiveness has been determined and results are reported in this paper.

  12. Overview of Light-Ion Beam Therapy

    SciTech Connect

    Chu, William T.

    2006-03-16

    compared to those in conventional (photon) treatments. Wilson wrote his personal account of this pioneering work in 1997. In 1954 Cornelius Tobias and John Lawrence at the Radiation Laboratory (former E.O. Lawrence Berkeley National Laboratory) of the University of California, Berkeley performed the first therapeutic exposure of human patients to hadron (deuteron and helium ion) beams at the 184-Inch Synchrocyclotron. By 1984, or 30 years after the first proton treatment at Berkeley, programs of proton radiation treatments had opened at: University of Uppsala, Sweden, 1957; the Massachusetts General Hospital-Harvard Cyclotron Laboratory (MGH/HCL), USA, 1961; Dubna (1967), Moscow (1969) and St Petersburg (1975) in Russia; Chiba (1979) and Tsukuba (1983) in Japan; and Villigen, Switzerland, 1984. These centers used the accelerators originally constructed for nuclear physics research. The experience at these centers has confirmed the efficacy of protons and light ions in increasing the tumor dose relative to normal tissue dose, with significant improvements in local control and patient survival for several tumor sites. M.R. Raju reviewed the early clinical studies. In 1990, the Loma Linda University Medical Center in California heralded in the age of dedicated medical accelerators when it commissioned its proton therapy facility with a 250-MeV synchrotron. Since then there has been a relatively rapid increase in the number of hospital-based proton treatment centers around the world, and by 2006 there are more than a dozen commercially-built facilities in use, five new facilities under construction, and more in planning stages. In the 1950s larger synchrotrons were built in the GeV region at Brookhaven (3-GeV Cosmotron) and at Berkeley (6-GeV Bevatron), and today most of the world's largest accelerators are synchrotrons. With advances in accelerator design in the early 1970s, synchrotrons at Berkeley and Princeton accelerated ions with atomic numbers between 6 and 18, at

  13. SU-E-T-577: Obliquity Factor and Surface Dose in Proton Beam Therapy

    SciTech Connect

    Das, I; Andersen, A; Coutinho, L

    2015-06-15

    Purpose: The advantage of lower skin dose in proton beam may be diminished creating radiation related sequalae usually seen with photon and electron beams. This study evaluates the surface dose as a complex function of beam parameters but more importantly the effect of beam angle. Methods: Surface dose in proton beam depends on the beam energy, source to surface distance, the air gap between snout and surface, field size, material thickness in front of surface, atomic number of the medium, beam angle and type of nozzle (ie double scattering, (DS), uniform scanning (US) or pencil beam scanning (PBS). Obliquity factor (OF) is defined as ratio of surface dose in 0° to beam angle Θ. Measurements were made in water phantom at various beam angles using very small microdiamond that has shown favorable beam characteristics for high, medium and low proton energy. Depth dose measurements were performed in the central axis of the beam in each respective gantry angle. Results: It is observed that surface dose is energy dependent but more predominantly on the SOBP. It is found that as SSD increases, surface dose decreases. In general, SSD, and air gap has limited impact in clinical proton range. High energy has higher surface dose and so the beam angle. The OF rises with beam angle. Compared to OF of 1.0 at 0° beam angle, the value is 1.5, 1.6, 1,7 for small, medium and large range respectively for 60 degree angle. Conclusion: It is advised that just like range and SOBP, surface dose should be clearly understood and a method to reduce the surface dose should be employed. Obliquity factor is a critical parameter that should be accounted in proton beam therapy and a perpendicular beam should be used to reduce surface dose.

  14. Upgrading prostate cancer following proton beam therapy.

    PubMed

    Logan, Jennifer K; Rais-Bahrami, Soroush; Merino, Maria J; Pinto, Peter A

    2015-01-01

    Pre- and post-radiation therapy (RT) effects on prostate histology have not been rigorously studied, but there appears to be a correlation between escalating radiation dosage and increasing post-RT histologic changes. Despite this dose-response relationship, radiation-induced changes may be heterogenous among different patients and even within a single tumor. When assessing residual tumor it is important to understand biopsy evaluation in the post-RT setting. We present the case of a poorly differentiated prostate adenocarcinoma following proton beam RT in a 45-year-old man with pre-RT Gleason 4 + 3 = 7 disease diagnosed in the setting of an elevated serum prostate-specific antigen level.

  15. Combined modulated electron and photon beams planned by a Monte-Carlo-based optimization procedure for accelerated partial breast irradiation.

    PubMed

    Palma, Bianey Atriana; Sánchez, Ana Ureba; Salguero, Francisco Javier; Arráns, Rafael; Sánchez, Carlos Míguez; Zurita, Amadeo Walls; Hermida, María Isabel Romero; Leal, Antonio

    2012-03-07

    The purpose of this study was to present a Monte-Carlo (MC)-based optimization procedure to improve conventional treatment plans for accelerated partial breast irradiation (APBI) using modulated electron beams alone or combined with modulated photon beams, to be delivered by a single collimation device, i.e. a photon multi-leaf collimator (xMLC) already installed in a standard hospital. Five left-sided breast cases were retrospectively planned using modulated photon and/or electron beams with an in-house treatment planning system (TPS), called CARMEN, and based on MC simulations. For comparison, the same cases were also planned by a PINNACLE TPS using conventional inverse intensity modulated radiation therapy (IMRT). Normal tissue complication probability for pericarditis, pneumonitis and breast fibrosis was calculated. CARMEN plans showed similar acceptable planning target volume (PTV) coverage as conventional IMRT plans with 90% of PTV volume covered by the prescribed dose (D(p)). Heart and ipsilateral lung receiving 5% D(p) and 15% D(p), respectively, was 3.2-3.6 times lower for CARMEN plans. Ipsilateral breast receiving 50% D(p) and 100% D(p) was an average of 1.4-1.7 times lower for CARMEN plans. Skin and whole body low-dose volume was also reduced. Modulated photon and/or electron beams planned by the CARMEN TPS improve APBI treatments by increasing normal tissue sparing maintaining the same PTV coverage achieved by other techniques. The use of the xMLC, already installed in the linac, to collimate photon and electron beams favors the clinical implementation of APBI with the highest efficiency.

  16. Evaluation of multileaf collimator design for a photon beam.

    PubMed

    Galvin, J M; Smith, A R; Moeller, R D; Goodman, R L; Powlis, W D; Rubenstein, J; Solin, L J; Michael, B; Needham, M; Huntzinger, C J

    1992-01-01

    Various aspects of multileaf collimator (MLC) design are examined relative to clinical requirements. The characteristics studied included: (a) irregular field edge definition or "effective" penumbra, (b) optimum field coverage for the multileaf portion of the field, and (c) leaf velocity. A film dosimetry technique was developed to measure the rapid 2-dimensional change in dose at an edge defined by a multileaf collimator with the segments staggered. The method applies a correction factor which allows for the changing ratio of scattered to primary photons at the field edge so that the energy dependence of the film is corrected. Stepped lead alloy blocks were irradiated with 6 MV photons to obtain films simulating a double-focused multileaf collimator, and the results were compared to films of fields shaped with standard divergent blocks. The effect of the shape of the leaf face (the end of the leaf) on penumbra was also studied. Proper shaping of the leaf ends may eliminate the need to exactly match beam divergence so that the mechanical of the collimator system is simplified. Leaves having several different end shapes and moving horizontally to intercept a vertical beam were compared to the divergent design where a straight face moves along an arc. The measurements showed that the "effective" penumbra (measured as the distance from the 80 to 20% isodose lines) for the multileaf collimator is a function of the angle between the direction of leaf motion and the edge defined by the leaves. In addition, all leaf end shapes showed some increase in penumbra compared to standard divergent blocking and also had increasing penumbra width as they moved over or back from the field center line. A total of 459 treatment fields and six disease sites were examined to determine the percentage of fields potentially shaped by multileaf segments of specified length. This study showed 93% of the fields had lengths of 30 cm or less and 99% had widths of 25 cm or less. A study

  17. Exotic radiation from a photonic crystal excited by an ultrarelativistic electron beam.

    PubMed

    Horiuchi, N; Ochiai, T; Inoue, J; Segawa, Y; Shibata, Y; Ishi, K; Kondo, Y; Kanbe, M; Miyazaki, H; Hinode, F; Yamaguti, S; Ohtaka, K

    2006-11-01

    We report the observation of an exotic radiation (unconventional Smith-Purcell radiation) from a one-dimensional photonic crystal. The physical origin of the exotic radiation is direct excitation of the photonic bands by an ultrarelativistic electron beam. The spectrum of the exotic radiation follows photonic bands of a certain parity, in striking contrast to the conventional Smith-Purcell radiation, which shows solely a linear dispersion. Key ingredients for the observation are the facts that the electron beam is in an ultrarelativistic region and that the photonic crystal is finite. The origin of the radiation was identified by comparison of experimental and theoretical results.

  18. Proton beam therapy in Japan: current and future status.

    PubMed

    Sakurai, Hideyuki; Ishikawa, Hitoshi; Okumura, Toshiyuki

    2016-10-01

    The number of patients treated by proton beam therapy in Japan since 2000 has increased; in 2016, 11 proton facilities were available to treat patients. Notably, proton beam therapy is very useful for pediatric cancer; since the pediatric radiation dose to normal tissues should be reduced as much as possible because of the effect of radiation on growth, intellectual development, endocrine organ function and secondary cancer development. Hepatocellular carcinoma is common in Asia, and most of the studies of proton beam therapy for liver cancer have been reported by Japanese investigators. Proton beam therapy is also a standard treatment for nasal and paranasal lesions and lesions at the base of the skull, because the radiation dose to critical organs such as the eyes, optic nerves and central nervous system can be reduced with proton beam therapy. For prostate cancer, comparative studies that address adverse effects, safety, patient quality of life and socioeconomic issues should be performed to determine the appropriate use of proton beam therapy for prostate cancer. Regarding new proton beam therapy applications, experience with proton beam therapy combined with chemotherapy is limited, although favorable outcomes have been recently reported for locally advanced lung cancer, esophageal cancer and pancreatic cancer. Therefore, 'chemoproton' therapy appears to be a very attractive field for further clinical investigations. In conclusion, there are cost issues and considerations regarding national insurance for the use of proton beam therapy in Japan. Further studies and discussions are needed to address the use of proton beam therapy for several types of cancers, and for maintaining the quality of life of patients while retaining a high cure rate.

  19. Respiratory gating for proton beam scanning versus photon 3D-CRT for breast cancer radiotherapy.

    PubMed

    Flejmer, Anna M; Edvardsson, Anneli; Dohlmar, Frida; Josefsson, Dan; Nilsson, Mats; Witt Nyström, Petra; Dasu, Alexandru

    2016-05-01

    Background Respiratory gating and proton therapy have both been proposed to reduce the cardiopulmonary burden in breast cancer radiotherapy. This study aims to investigate the additional benefit of proton radiotherapy for breast cancer with and without respiratory gating. Material and methods Twenty left-sided patients were planned on computed tomography (CT)-datasets acquired during enhanced inspiration gating (EIG) and free-breathing (FB), using photon three-dimensional conformal radiation therapy (3D-CRT) and scanned proton beams. Ten patients received treatment to the whole breast only (WBO) and 10 were treated to the breast and the regional lymph nodes (BRN). Dosimetric parameters characterizing the coverage of target volumes and the cardiopulmonary burden were compared using a paired, two-tailed Student's t-test. Results Protons ensured comparable or better target coverage than photons in all patients during both EIG and FB. The heterogeneity index decreased from 12% with photons to about 5% with protons. The mean dose to the ipsilateral lung was reduced in BRN patients from 12 Gy to 7 Gy  (RBE) in EIG and from 14 Gy to 6-7 Gy (RBE) in FB, while for WBO patients all values were about 5-6 Gy (RBE). The mean dose to heart decreased by a factor of four in WBO patients [from 1.1 Gy to 0.3 Gy (RBE) in EIG and from 2.1 Gy to 0.5 Gy (RBE) in FB] and 10 in BRN patients [from 2.1 Gy to 0.2 Gy (RBE) in EIG and from 3.4 Gy to 0.3 Gy (RBE) in FB]. Similarly, the mean and the near maximum dose to the left anterior descending artery (LAD) were significantly lower (p < 0.05) with protons in comparison with photons. Conclusion Proton spot scanning has a high potential to reduce the irradiation of organs at risk and other normal tissues for most patients, beyond what could be achieved with EIG and photon therapy. The largest dose sparing has been seen for BRN patients, both in terms of cardiopulmonary burden and integral dose.

  20. Microdosimetry in ion-beam therapy

    NASA Astrophysics Data System (ADS)

    Magrin, Giulio; Mayer, Ramona

    2015-05-01

    The information of the dose is not sufficiently describing the biological effects of ions on tissue since it does not express the radiation quality, i.e. the heterogeneity of the processes due to the slowing-down and the fragmentation of the particles when crossing a target. Depending on different circumstances, the radiation quality can be determined using measurements, calculations, or simulations. Microdosimeters are the primary tools used to provide the experimental information of the radiation quality and their role is becoming crucial for the recent clinical developments in particular with carbon ion therapy. Microdosimetry is strongly linked to the biological effectiveness of the radiation since it provides the physical parameters which explicitly distinguish the radiation for its capability of damaging cells. In the framework of ion-beam therapy microdosimetry can be used in the preparation of the treatment to complement radiobiological experiments and to analyze the modification of the radiation quality in phantoms. A more ambitious goal is to perform the measurements during the irradiation procedure to determine the non-targeted radiation and, more importantly, to monitor the modification of the radiation quality inside the patient. These procedures provide the feedback of the treatment directly beneficial for the single patient but also for the characterization of the biological effectiveness in general with advantages for all future treatment. Traditional and innovative tools are currently under study and an outlook of present experience and future development is presented here.

  1. Femtosecond correlated photon echo in CdS crystal under two-photon excitation by two pairs of crossed laser beams

    NASA Astrophysics Data System (ADS)

    Samartsev, V. V.; Leontiev, A. V.; Mitrofanova, T. G.

    2015-07-01

    We consider the possibility of observing a femtosecond correlated photon echo (FCPE) under two-photon excitation of CdS crystal by two pairs of crossed laser beams. The peculiarities of FCPE signals and their possible applications are discussed.

  2. Analyzing the characteristics of 6 MV photon beam at low monitor unit settings

    PubMed Central

    Nithya, L.; Raj, N. Arunai Nambi; Rathinamuthu, Sasikumar

    2016-01-01

    Analyzing the characteristics of a low monitor unit (MU) setting is essential, particularly for intensity-modulated techniques. Intensity modulation can be achieved through intensity-modulated radiotherapy (IMRT) or volumetric-modulated arc therapy (VMAT). There is possibility for low MUs in the segments of IMRT and VMAT plans. The minimum MU/segment must be set by the physicist in the treatment planning system at the time of commissioning. In this study, the characteristics such as dose linearity, stability, flatness, and symmetry of 6 MV photon beam of a Synergy linear accelerator at low MU settings were investigated for different dose rates. The measurements were performed for Synergy linear accelerator using a slab phantom with a FC65-G chamber and Profiler 2. The MU linearity was studied for 1–100 MU using a field size of 10 cm ×10 cm. The linearity error for 1 MU was 4.2%. Flatness of the beam was deteriorated in 1 MU condition. The beam stability and symmetry was well within the specification. Using this study, we conclude that the treatment delivered with <3 MU may result in uncertainty in dose delivery. To ensure the correct dose delivery with less uncertainty, it is recommended to use ≥3 MU as the minimum MU per segment in IMRT and VMAT plans. PMID:27051168

  3. Evaluation of dosimetric properties of 6 MV & 10 MV photon beams from a linear accelerator with no flattening filter

    NASA Astrophysics Data System (ADS)

    Pearson, David

    A linear accelerator manufactured by Elekta, equipped with a multi leaf collimation (MLC) system has been modelled using Monte Carlo simulations with the photon flattening filter removed. The purpose of this investigation was to show that more efficient and more accurate Intensity Modulated Radiation Therapy (IMRT) treatments can be delivered from a standard linear accelerator with the flattening filter removed from the beam. A range of simulations of 6 MV and 10 MV photon were studied and compared to a model of a standard accelerator which included the flattening filter for those beams. Measurements using a scanning water phantom were also performed after the flattening filter had been removed. We show here that with the flattening filter removed, an increase to the dose on the central axis by a factor of 2.35 and 4.18 is achieved for 6 MV and 10 MV photon beams respectively using a standard 10x 10cm2 field size. A comparison of the dose at points at the field edges led to the result that, removal of the flattening filter reduced the dose at these points by approximately 10% for the 6 MV beam over the clinical range of field sizes. A further consequence of removing the flattening filter was the softening of the photon energy spectrum leading to a steeper reduction in dose at depths greater than dmax. Also studied was the electron contamination brought about by the removal of the filter. To reduce this electron contamination and thus reduce the skin dose to the patient we consider the use of an electron scattering foil in the beam path. The electron scattering foil had very little effect on dmax. From simulations of a standard 6MV beam, a filter-free beam and a filter-free beam with electron scattering foil, we deduce that the proportion of electrons in the photon beam is 0.35%, 0.28% and 0.27%, consecutively. In short, higher dose rates will result in decreased treatment times and the reduced dose outside of the field is indicative of reducing the dose to the

  4. Proton Arc Reduces Range Uncertainty Effects and Improves Conformality Compared With Photon Volumetric Modulated Arc Therapy in Stereotactic Body Radiation Therapy for Non-Small Cell Lung Cancer

    SciTech Connect

    Seco, Joao; Gu, Guan; Marcelos, Tiago; Kooy, Hanne; Willers, Henning

    2013-09-01

    Purpose: To describe, in a setting of non-small cell lung cancer (NSCLC), the theoretical dosimetric advantages of proton arc stereotactic body radiation therapy (SBRT) in which the beam penumbra of a rotating beam is used to reduce the impact of range uncertainties. Methods and Materials: Thirteen patients with early-stage NSCLC treated with proton SBRT underwent repeat planning with photon volumetric modulated arc therapy (Photon-VMAT) and an in-house-developed arc planning approach for both proton passive scattering (Passive-Arc) and intensity modulated proton therapy (IMPT-Arc). An arc was mimicked with a series of beams placed at 10° increments. Tumor and organ at risk doses were compared in the context of high- and low-dose regions, represented by volumes receiving >50% and <50% of the prescription dose, respectively. Results: In the high-dose region, conformality index values are 2.56, 1.91, 1.31, and 1.74, and homogeneity index values are 1.29, 1.22, 1.52, and 1.18, respectively, for 3 proton passive scattered beams, Passive-Arc, IMPT-Arc, and Photon-VMAT. Therefore, proton arc leads to a 30% reduction in the 95% isodose line volume to 3-beam proton plan, sparing surrounding organs, such as lung and chest wall. For chest wall, V30 is reduced from 21 cm{sup 3} (3 proton beams) to 11.5 cm{sup 3}, 12.9 cm{sup 3}, and 8.63 cm{sup 3} (P=.005) for Passive-Arc, IMPT-Arc, and Photon-VMAT, respectively. In the low-dose region, the mean lung dose and V20 of the ipsilateral lung are 5.01 Gy(relative biological effectiveness [RBE]), 4.38 Gy(RBE), 4.91 Gy(RBE), and 5.99 Gy(RBE) and 9.5%, 7.5%, 9.0%, and 10.0%, respectively, for 3-beam, Passive-Arc, IMPT-Arc, and Photon-VMAT, respectively. Conclusions: Stereotactic body radiation therapy with proton arc and Photon-VMAT generate significantly more conformal high-dose volumes than standard proton SBRT, without loss of coverage of the tumor and with significant sparing of nearby organs, such as chest wall. In addition

  5. Beam-Gas and Thermal Photon Scattering in the NLC Main Linac as a Source of Beam Halo (LCC-0051)

    SciTech Connect

    Tenenbaum, P

    2004-03-19

    Scattering of primary beam electrons off of residual gas molecules or blackbody radiation photons in the NLC main linac has been identified as a potential source of beam haloes which must be collimated in the beam delivery system. We consider the contributions from four scattering mechanisms: inelastic thermal-photon scattering, elastic beam-gas (Coulomb) scattering inelastic beam-gas (Bremsstrahlung) scattering, and atomic-electron scattering. In each case we develop the formalism necessary to estimate the backgrounds generated in the main linac, and determine the expected number of off-energy or large-amplitude particles from each process, assuming a main linac injection energy of 8 GeV and extraction energy of 500 GeV.

  6. SU-E-T-597: Parameterization of the Photon Beam Dosimetry for a Commercial Linear Accelerator

    SciTech Connect

    Lebron, S; Lu, B; Yan, G; Kahler, D; Li, J; Barraclough, B; Liu, C

    2015-06-15

    Purpose: In radiation therapy, accurate data acquisition of photon beam dosimetric quantities is important for (1) beam modeling data input into a treatment planning system (TPS), (2) comparing measured and TPS modelled data, (3) a linear accelerator’s (linac) beam characteristics quality assurance process, and (4) establishing a standard data set for data comparison, etcetera. Parameterization of the photon beam dosimetry creates a portable data set that is easy to implement for different applications such as those previously mentioned. The aim of this study is to develop methods to parameterize photon percentage depth doses(PDD), profiles, and total scatter output factors(Scp). Methods: Scp, PDDs and profiles for different field sizes (from 2×2 to 40×40cm{sup 2}), depths and energies were measured in a linac using a three-dimensional water tank. All data were smoothed and profile data were also centered, symmetrized and geometrically scaled. The Scp and PDD data were analyzed using exponential functions. For modelling of open and wedge field profiles, each side was divided into three regions described by exponential, sigmoid and Gaussian equations. The model’s equations were chosen based on the physical principles described by these dosimetric quantities. The equations’ parameters were determined using a least square optimization method with the minimal amount of measured data necessary. The model’s accuracy was then evaluated via the calculation of absolute differences and distance–to–agreement analysis in low gradient and high gradient regions, respectively. Results: All differences in the PDDs’ buildup and the profiles’ penumbra regions were less than 2 mm and 0.5 mm, respectively. Differences in the low gradient regions were 0.20 ± 0.20% and 0.50 ± 0.35% for PDDs and profiles, respectively. For Scp data, all differences were less than 0.5%. Conclusion: This novel analytical model with minimum measurement requirements proved to accurately

  7. Azimuthal and radial shaping of vortex beams generated in twisted nonlinear photonic crystals.

    PubMed

    Shemer, Keren; Voloch-Bloch, Noa; Shapira, Asia; Libster, Ana; Juwiler, Irit; Arie, Ady

    2013-12-15

    We experimentally demonstrate that the orbital angular momentum (OAM) of a second harmonic (SH) beam, generated within twisted nonlinear photonic crystals, depends both on the OAM of the input pump beam and on the quasi-angular momentum of the crystal. In addition, when the pump's radial index is zero, the radial index of the SH beam is equal to that of the nonlinear crystal. Furthermore, by mixing two noncollinear pump beams in this crystal, we generate, in addition to the SH beams, a new "virtual beam" having multiple values of OAM that are determined by the nonlinear process.

  8. Electron and photon beams from a 50 MeV racetrack microtron.

    PubMed

    Brahme, A; Kraepelien, T; Svensson, H

    1980-01-01

    The quality of broad high energy photon and electron beams can be improved considerably by the scanning of elementary narrow beams. Dose distributions produced in this way have advantages with respect to improved dose gradients and therapeutic ranges for electrons and lower surface doses, increased depth doses and half value depths for photons. The possibility of giving the whole therapeutic dose in a single local pulse of short duration is discussed as a new method to protect superficial tissues.

  9. Photon-number statistics of twin beams: Self-consistent measurement, reconstruction, and properties

    SciTech Connect

    Peřina, Jan Jr.; Haderka, Ondřej; Michálek, Václav

    2014-12-04

    A method for the determination of photon-number statistics of twin beams using the joint signal-idler photocount statistics obtained by an iCCD camera is described. It also provides absolute quantum detection efficiency of the camera. Using the measured photocount statistics, quasi-distributions of integrated intensities are obtained. They attain negative values occurring in characteristic strips an a consequence of pairing of photons in twin beams.

  10. Highly integrated optical phased arrays: photonic integrated circuits for optical beam shaping and beam steering

    NASA Astrophysics Data System (ADS)

    Heck, Martijn J. R.

    2016-06-01

    Technologies for efficient generation and fast scanning of narrow free-space laser beams find major applications in three-dimensional (3D) imaging and mapping, like Lidar for remote sensing and navigation, and secure free-space optical communications. The ultimate goal for such a system is to reduce its size, weight, and power consumption, so that it can be mounted on, e.g. drones and autonomous cars. Moreover, beam scanning should ideally be done at video frame rates, something that is beyond the capabilities of current opto-mechanical systems. Photonic integrated circuit (PIC) technology holds the promise of achieving low-cost, compact, robust and energy-efficient complex optical systems. PICs integrate, for example, lasers, modulators, detectors, and filters on a single piece of semiconductor, typically silicon or indium phosphide, much like electronic integrated circuits. This technology is maturing fast, driven by high-bandwidth communications applications, and mature fabrication facilities. State-of-the-art commercial PICs integrate hundreds of elements, and the integration of thousands of elements has been shown in the laboratory. Over the last few years, there has been a considerable research effort to integrate beam steering systems on a PIC, and various beam steering demonstrators based on optical phased arrays have been realized. Arrays of up to thousands of coherent emitters, including their phase and amplitude control, have been integrated, and various applications have been explored. In this review paper, I will present an overview of the state of the art of this technology and its opportunities, illustrated by recent breakthroughs.

  11. Highly integrated optical phased arrays: photonic integrated circuits for optical beam shaping and beam steering

    NASA Astrophysics Data System (ADS)

    Heck, Martijn J. R.

    2017-01-01

    Technologies for efficient generation and fast scanning of narrow free-space laser beams find major applications in three-dimensional (3D) imaging and mapping, like Lidar for remote sensing and navigation, and secure free-space optical communications. The ultimate goal for such a system is to reduce its size, weight, and power consumption, so that it can be mounted on, e.g. drones and autonomous cars. Moreover, beam scanning should ideally be done at video frame rates, something that is beyond the capabilities of current opto-mechanical systems. Photonic integrated circuit (PIC) technology holds the promise of achieving low-cost, compact, robust and energy-efficient complex optical systems. PICs integrate, for example, lasers, modulators, detectors, and filters on a single piece of semiconductor, typically silicon or indium phosphide, much like electronic integrated circuits. This technology is maturing fast, driven by high-bandwidth communications applications, and mature fabrication facilities. State-of-the-art commercial PICs integrate hundreds of elements, and the integration of thousands of elements has been shown in the laboratory. Over the last few years, there has been a considerable research effort to integrate beam steering systems on a PIC, and various beam steering demonstrators based on optical phased arrays have been realized. Arrays of up to thousands of coherent emitters, including their phase and amplitude control, have been integrated, and various applications have been explored. In this review paper, I will present an overview of the state of the art of this technology and its opportunities, illustrated by recent breakthroughs.

  12. Spatial mapping of the biologic effectiveness of scanned particle beams: towards biologically optimized particle therapy

    PubMed Central

    Guan, Fada; Bronk, Lawrence; Titt, Uwe; Lin, Steven H.; Mirkovic, Dragan; Kerr, Matthew D.; Zhu, X. Ronald; Dinh, Jeffrey; Sobieski, Mary; Stephan, Clifford; Peeler, Christopher R.; Taleei, Reza; Mohan, Radhe; Grosshans, David R.

    2015-01-01

    The physical properties of particles used in radiation therapy, such as protons, have been well characterized, and their dose distributions are superior to photon-based treatments. However, proton therapy may also have inherent biologic advantages that have not been capitalized on. Unlike photon beams, the linear energy transfer (LET) and hence biologic effectiveness of particle beams varies along the beam path. Selective placement of areas of high effectiveness could enhance tumor cell kill and simultaneously spare normal tissues. However, previous methods for mapping spatial variations in biologic effectiveness are time-consuming and often yield inconsistent results with large uncertainties. Thus the data needed to accurately model relative biological effectiveness to guide novel treatment planning approaches are limited. We used Monte Carlo modeling and high-content automated clonogenic survival assays to spatially map the biologic effectiveness of scanned proton beams with high accuracy and throughput while minimizing biological uncertainties. We found that the relationship between cell kill, dose, and LET, is complex and non-unique. Measured biologic effects were substantially greater than in most previous reports, and non-linear surviving fraction response was observed even for the highest LET values. Extension of this approach could generate data needed to optimize proton therapy plans incorporating variable RBE. PMID:25984967

  13. Mixing intensity modulated electron and photon beams: combining a steep dose fall-off at depth with sharp and depth-independent penumbras and flat beam profiles.

    PubMed

    Korevaar, E W; Heijmen, B J; Woudstra, E; Huizenga, H; Brahme, A

    1999-09-01

    For application in radiotherapy, intensity modulated high-energy electron and photon beams were mixed to create dose distributions that feature: (a) a steep dose fall-off at larger depths, similar to pure electron beams, (b) flat beam profiles and sharp and depth-independent beam penumbras, as in photon beams, and (c) a selectable skin dose that is lower than for pure electron beams. To determine the required electron and photon beam fluence profiles, an inverse treatment planning algorithm was used. Mixed beams were realized at a MM50 racetrack microtron (Scanditronix Medical AB, Sweden), and evaluated by the dose distributions measured in a water phantom. The multileaf collimator of the MM50 was used in a static mode to shape overlapping electron beam segments, and the dynamic multileaf collimation mode was used to realize the intensity modulated photon beam profiles. Examples of mixed beams were generated at electron energies of up to 40 MeV. The intensity modulated electron beam component consists of two overlapping concentric fields with optimized field sizes, yielding broad, fairly depth-independent overall beam penumbras. The matched intensity modulated photon beam component has high fluence peaks at the field edges to sharpen this penumbra. The combination of the electron and the photon beams yields dose distributions with the characteristics (a)-(c) mentioned above.

  14. Cherenkov imaging during volumetric modulated arc therapy for real-time radiation beam tracking and treatment response monitoring

    NASA Astrophysics Data System (ADS)

    Andreozzi, Jacqueline M.; Zhang, Rongxiao; Glaser, Adam K.; Gladstone, David J.; Jarvis, Lesley A.; Pogue, Brian W.

    2016-03-01

    External beam radiotherapy utilizes high energy radiation to target cancer with dynamic, patient-specific treatment plans. The otherwise invisible radiation beam can be observed via the optical Cherenkov photons emitted from interaction between the high energy beam and tissue. Using a specialized camera-system, the Cherenkov emission can thus be used to track the radiation beam on the surface of the patient in real-time, even for complex cases such as volumetric modulated arc therapy (VMAT). Two patients undergoing VMAT of the head and neck were imaged and analyzed, and the viability of the system to provide clinical feedback was established.

  15. Comparison of Gafchromic EBT2 and EBT3 films for clinical photon and proton beams

    SciTech Connect

    Reinhardt, S.; Hillbrand, M.; Wilkens, J. J.; Assmann, W.

    2012-08-15

    Purpose: Dose verification in highly conformal radiation therapy such as IMRT or proton therapy can benefit from the high spatial resolution offered by radio-chromic films such as Gafchromic EBT or EBT2. Recently, a new generation of these films, EBT3, has become available. The composition and thickness of the sensitive layer are the same as for the previous EBT2 films. The most important change is the symmetric layer configuration to eliminate side orientation dependence, which is reported for EBT2 films. Methods: The general film characteristics such as sensitivity to read-out orientation and postexposure darkening evolution of the new EBT3 film are evaluated. Film response has been investigated in clinical photon and proton beams and compared to former EBT2 films. Quenching effects in the proton Bragg peak region have been studied for both, EBT2 and EBT3 films. Results: The general performance of EBT3 is comparable to EBT2, and the orientation dependence with respect to film side is completely eliminated in EBT3 films. Response differences of EBT2 and EBT3 films are of the same order of magnitude as batch-to-batch variations observed for EBT2 films. No significant difference has been found for both generations of EBT films between photon and proton exposure. Depth dose measurements of EBT2 and EBT3 show an excellent agreement, though underestimating dose by up to 20% in the Bragg peak region. Conclusions: The symmetric configuration of EBT3 presents a major improvement for film handling. EBT3 has similar dosimetric performance as its precursor EBT2 and can, thus, be applied to dose verification in IMRT in the same way. For dose verification in proton therapy the underresponse in the Bragg peak region has to be taken into account.

  16. Dosimetric properties of a scanned beam microtron at low monitor unit settings: importance for conformal therapy.

    PubMed

    Humm, J L; Larsson, A; Lief, E P

    1996-03-01

    The dosimetric stability, linearity, dose rate dependence, and flatness of both photon and electron beams have been evaluated for a racetrack microtron at low monitor unit settings. For photons, the variation in dosimetric output about the mean is < 0.4% at 100 monitor units (MU), < 1% at 10 MU, and < 4% at 2 MU. The output dependence on the dose rate varied by < 0.6% between 85-300 MU/min. Flatness and symmetry for the 25- and 50-MV beams showed deviations of < 3% at both dmax and 10-cm depths, and only slightly > 3% at 20 cm, even at only 3 MU, in contrast with other scanned beam accelerators. Broad electron beams on the microtron are created by the superposition of the elementary beam pulses either directly from the scan magnets, or after their broadening through a scattering foil. The dosimetric instability both with and without the foil was less than 0.6% for both the 25- and 50-MeV electrons. Dose nonlinearity was < 1% above 10 MU. Field flatness was determined for scan matrices designed to produce a flat field both with and without a scattering foil. Symmetry and flatness deviations were < 3% for both electron energies when a scattering foil was used, even for a single scan. The variation of the electron dose per monitor unit between dose rates of 85-300 MU/min was < 1% (25 MeV) and < 4% (50 MeV) when a scattering foil was used, but as high as 22% (25 MeV) and 36% (50 MeV) for broad beams generated by elementary beam pulses directly from the scanning magnets. The microtron exhibits dosimetric properties which fulfill the recommendations of Task Groups 21 and 25. Based on the stability of the scanned beam at low monitor unit settings, the microtron can be used for 3-D conformal therapy with both photons and electrons.

  17. Beam control and multi-color routing with spatial photonic defect modes.

    PubMed

    Wang, Xiaosheng; Chen, Zhigang

    2009-09-14

    We demonstrate tunable re-directing, blocking, and splitting of a light beam along defect channels based on spatial bandgap guidance in two-dimensional photonic lattices. We show the possibility for linear control of beam propagation and multicolor routing with specially designed junctions and surface structures embedded in otherwise uniform square lattices.

  18. Investigation of the possibility of using photoneutron beams for radiation therapy.

    PubMed

    Brahme, A; Montelius, A; Nordell, B; Reuthal, M; Svensson, H

    1980-11-01

    The possibility has been investigated of using electrons accelerated by a 50 MeV racetrack microtron for generation of photoneutron beams for radiation therapy. Central axis depth-dose curves have been measured in an A-150 tissue-equivalent phantom. Neutron half-value depths between 4.4 and 5.2 g cm-2 were obtained at an SSD of 100 cm for different converter materials and target geometries. At an absorbed dose ratio of 1:1 for neutrons and photons at the dose maximum, the total absorbed dose rates are estimated to be 0.1 Gy min-1 at 100 micronA electron current and a SSD of 100 cm. At a depth of 5 cm the neutron to photon absorbed dose ratio is typically 1:2 and the OER is expected to be about 1.8. Some dose distributional and radiobiological advantages of a physically mixed beam of neutrons and photons for external beam radiation therapy are discussed.

  19. What to Know about External Beam Radiation Therapy

    MedlinePlus

    ... wife and children.” U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health About the treatment: What is external beam radiation therapy? ■ It is a common cancer treatment that ...

  20. Modeling silicon diode energy response factors for use in therapeutic photon beams.

    PubMed

    Eklund, Karin; Ahnesjö, Anders

    2009-10-21

    Silicon diodes have good spatial resolution, which makes them advantageous over ionization chambers for dosimetry in fields with high dose gradients. However, silicon diodes overrespond to low-energy photons, that are more abundant in scatter which increase with large fields and larger depths. We present a cavity-theory-based model for a general response function for silicon detectors at arbitrary positions within photon fields. The model uses photon and electron spectra calculated from fluence pencil kernels. The incident photons are treated according to their energy through a bipartition of the primary beam photon spectrum into low- and high-energy components. Primary electrons from the high-energy component are treated according to Spencer-Attix cavity theory. Low-energy primary photons together with all scattered photons are treated according to large cavity theory supplemented with an energy-dependent factor K(E) to compensate for energy variations in the electron equilibrium. The depth variation of the response for an unshielded silicon detector has been calculated for 5 x 5 cm(2), 10 x 10 cm(2) and 20 x 20 cm(2) fields in 6 and 15 MV beams and compared with measurements showing that our model calculates response factors with deviations less than 0.6%. An alternative method is also proposed, where we show that one can use a correlation with the scatter factor to determine the detector response of silicon diodes with an error of less than 3% in 6 MV and 15 MV photon beams.

  1. Thomson scattering of polarized photons in an intense laser beam

    SciTech Connect

    Byung Yunn

    2006-02-21

    We present a theoretical analysis of the Thomson scattering of linearly and circularly polarized photons from a pulsed laser by electrons. The analytical expression for the photon distribution functions presented in this paper should be useful to designers of Thomson scattering experiments.

  2. Two photons on an atomic beam splitter: Nonlinear scattering and induced correlations

    NASA Astrophysics Data System (ADS)

    Roulet, Alexandre; Le, Huy Nguyen; Scarani, Valerio

    2016-03-01

    Optical emitters strongly coupled to photons propagating in one-dimensional waveguides are a promising platform for optical quantum information processing. Here, we present a theoretical study of the scattering of two indistinguishable photons on a single two-level atom in a Hong-Ou-Mandel setup. By computing the dynamics, we can describe the system at any time of the scattering event. This allows us to highlight the one-to-one correspondence between the saturation of the atom and the effective interaction induced between the photons. Furthermore, we discuss the integrability of the atomic beam splitter and provide an intuitive picture for the correlations observed between the outgoing photons.

  3. Entanglement of Photon-Added Nonlinear Coherent States Via a Beam Splitter

    NASA Astrophysics Data System (ADS)

    Honarasa, Gholamreza; Bagheri, Alireza; Gharaati, Abdolrasoul

    2016-10-01

    Nonlinear coherent states, photon-added coherent states and photon-added nonlinear coherent states are three of the important generalizations of standard coherent states. In this article, a photon-added nonlinear coherent state and a vacuum state are injected on two input modes of a beam splitter and the entanglement of the output state is investigated using linear entropy as the measure. Then, the impact of nonclassicality of the photon-added nonlinear coherent state on entanglement of the output state is studied.

  4. Review of ion beam therapy: Present and Future

    SciTech Connect

    Alonso, Jose R.

    2000-06-01

    First therapy efforts at the Bevalac using neon ions took place in the 70's and 80's. Promising results led to construction of HIMAC in Chiba Japan, and more recently to therapy trials at GSI. Both these facilities are now treating patients with carbon beams. Advances in both accelerator technology and beam delivery have taken place at these two centers. Plans are well along for new facilities in Europe and Japan.

  5. Hyperfractionated Concomitant Boost Proton Beam Therapy for Esophageal Carcinoma

    SciTech Connect

    Mizumoto, Masashi; Sugahara, Shinji; Okumura, Toshiyuki; Hashimoto, Takayuki; Oshiro, Yoshiko; Fukumitsu, Nobuyoshi; Nakahara, Akira; Terashima, Hideo; Tsuboi, Koji; Sakurai, Hideyuki

    2011-11-15

    Purpose: To evaluate the efficacy and safety of hyperfractionated concomitant boost proton beam therapy (PBT) for patients with esophageal cancer. Methods and Materials: The study participants were 19 patients with esophageal cancer who were treated with hyperfractionated photon therapy and PBT between 1990 and 2007. The median total dose was 78 GyE (range, 70-83 GyE) over a median treatment period of 48 days (range, 38-53 days). Ten of the 19 patients were at clinical T Stage 3 or 4. Results: There were no cases in which treatment interruption was required because of radiation-induced esophagitis or hematologic toxicity. The overall 1- and 5-year actuarial survival rates for all 19 patients were 79.0% and 42.8%, respectively, and the median survival time was 31.5 months (95% limits: 16.7- 46.3 months). Of the 19 patients, 17 (89%) showed a complete response within 4 months after completing treatment and 2 (11%) showed a partial response, giving a response rate of 100% (19/19). The 1- and 5-year local control rates for all 19 patients were 93.8% and 84.4 %, respectively. Only 1 patient had late esophageal toxicity of Grade 3 at 6 months after hyperfractionated PBT. There were no other nonhematologic toxicities, including no cases of radiation pneumonia or cardiac failure of Grade 3 or higher. Conclusions: The results suggest that hyperfractionated PBT is safe and effective for patients with esophageal cancer. Further studies are needed to establish the appropriate role and treatment schedule for use of PBT for esophageal cancer.

  6. Treatment planning, optimization, and beam delivery technqiues for intensity modulated proton therapy

    NASA Astrophysics Data System (ADS)

    Sengbusch, Evan R.

    Physical properties of proton interactions in matter give them a theoretical advantage over photons in radiation therapy for cancer treatment, but they are seldom used relative to photons. The primary barriers to wider acceptance of proton therapy are the technical feasibility, size, and price of proton therapy systems. Several aspects of the proton therapy landscape are investigated, and new techniques for treatment planning, optimization, and beam delivery are presented. The results of these investigations suggest a means by which proton therapy can be delivered more efficiently, effectively, and to a much larger proportion of eligible patients. An analysis of the existing proton therapy market was performed. Personal interviews with over 30 radiation oncology leaders were conducted with regard to the current and future use of proton therapy. In addition, global proton therapy market projections are presented. The results of these investigations serve as motivation and guidance for the subsequent development of treatment system designs and treatment planning, optimization, and beam delivery methods. A major factor impacting the size and cost of proton treatment systems is the maximum energy of the accelerator. Historically, 250 MeV has been the accepted value, but there is minimal quantitative evidence in the literature that supports this standard. A retrospective study of 100 patients is presented that quantifies the maximum proton kinetic energy requirements for cancer treatment, and the impact of those results with regard to treatment system size, cost, and neutron production is discussed. This study is subsequently expanded to include 100 cranial stereotactic radiosurgery (SRS) patients, and the results are discussed in the context of a proposed dedicated proton SRS treatment system. Finally, novel proton therapy optimization and delivery techniques are presented. Algorithms are developed that optimize treatment plans over beam angle, spot size, spot spacing

  7. Fabrication of novel three-dimensional photonic crystals using multi-beam interference lithography

    NASA Astrophysics Data System (ADS)

    Ramanan, Vinayak

    Optical Communications has seen an explosion in recent times with new types of devices and materials. In the last decade, considerable study has been devoted to the control of the optical properties of materials and guiding the propagation of light through the use of photonic crystals. Photonic crystals are materials with a periodic arrangement of dielectric medium in one, two or three dimensions, with periodicities on the order of the wavelength of the electromagnetic radiation in use. Photonic crystals exhibit photonic band gaps depending on their geometry and refractive index. Holographic lithography has been proven to be an attractive technique for the creation of large area, defect-free, three-dimensional photonic crystals. Structures with potential in photonic applications are fabricated in the photoresist SU-8, through concurrent exposure with four non-coplanar coherent beams of laser radiation. Polymer-air structures with face centered cubic symmetry are used as a template to create higher refractive index contrast photonic crystals by infilling using Atomic Layer Deposition and Chemical Vapor Deposition. These photonic crystals exhibit excellent optical properties with strong reflectance peaks at the calculated band gap frequencies. Two-photon polymerization is used to demonstrate the ability to create designed defect structures such as waveguides in silicon-air photonic crystals. Genetic algorithms are demonstrated as a technique to design an interference lithography experiment. A four-beam setup with beams originating in opposite hemispheres and linear polarizations is found to generate a structure with diamond symmetry and a large complete photonic band gap. Band gap studies on structures that possess both high band gap and high contrast are performed. The optical setup for a diamond structure utilizing two right-angled prisms is discussed and promising experimental results are presented.

  8. Integration and evaluation of automated Monte Carlo simulations in the clinical practice of scanned proton and carbon ion beam therapy.

    PubMed

    Bauer, J; Sommerer, F; Mairani, A; Unholtz, D; Farook, R; Handrack, J; Frey, K; Marcelos, T; Tessonnier, T; Ecker, S; Ackermann, B; Ellerbrock, M; Debus, J; Parodi, K

    2014-08-21

    Monte Carlo (MC) simulations of beam interaction and transport in matter are increasingly considered as essential tools to support several aspects of radiation therapy. Despite the vast application of MC to photon therapy and scattered proton therapy, clinical experience in scanned ion beam therapy is still scarce. This is especially the case for ions heavier than protons, which pose additional issues like nuclear fragmentation and varying biological effectiveness. In this work, we present the evaluation of a dedicated framework which has been developed at the Heidelberg Ion Beam Therapy Center to provide automated FLUKA MC simulations of clinical patient treatments with scanned proton and carbon ion beams. Investigations on the number of transported primaries and the dimension of the geometry and scoring grids have been performed for a representative class of patient cases in order to provide recommendations on the simulation settings, showing that recommendations derived from the experience in proton therapy cannot be directly translated to the case of carbon ion beams. The MC results with the optimized settings have been compared to the calculations of the analytical treatment planning system (TPS), showing that regardless of the consistency of the two systems (in terms of beam model in water and range calculation in different materials) relevant differences can be found in dosimetric quantities and range, especially in the case of heterogeneous and deep seated treatment sites depending on the ion beam species and energies, homogeneity of the traversed tissue and size of the treated volume. The analysis of typical TPS speed-up approximations highlighted effects which deserve accurate treatment, in contrast to adequate beam model simplifications for scanned ion beam therapy. In terms of biological dose calculations, the investigation of the mixed field components in realistic anatomical situations confirmed the findings of previous groups so far reported only in

  9. Heavy Charged Particle Radiobiology: Using Enhanced Biological Effectiveness and Improved Beam Focusing to Advance Cancer Therapy

    PubMed Central

    Allen, Christopher; Borak, Thomas B.; Tsujii, Hirohiko; Nickoloff, Jac A.

    2011-01-01

    Ionizing radiation causes many types of DNA damage, including base damage and single- and double-strand breaks. Photons, including X-rays and γ-rays, are the most widely used type of ionizing radiation in radiobiology experiments, and in radiation cancer therapy. Charged particles, including protons and carbon ions, are seeing increased use as an alternative therapeutic modality. Although the facilities needed to produce high energy charged particle beams are more costly than photon facilities, particle therapy has shown improved cancer survival rates, reflecting more highly focused dose distributions and more severe DNA damage to tumor cells. Despite early successes of charged particle radiotherapy, there is room for further improvement, and much remains to be learned about normal and cancer cell responses to charged particle radiation. PMID:21376738

  10. Heavy charged particle radiobiology: using enhanced biological effectiveness and improved beam focusing to advance cancer therapy.

    PubMed

    Allen, Christopher; Borak, Thomas B; Tsujii, Hirohiko; Nickoloff, Jac A

    2011-06-03

    Ionizing radiation causes many types of DNA damage, including base damage and single- and double-strand breaks. Photons, including X-rays and γ-rays, are the most widely used type of ionizing radiation in radiobiology experiments, and in radiation cancer therapy. Charged particles, including protons and carbon ions, are seeing increased use as an alternative therapeutic modality. Although the facilities needed to produce high energy charged particle beams are more costly than photon facilities, particle therapy has shown improved cancer survival rates, reflecting more highly focused dose distributions and more severe DNA damage to tumor cells. Despite early successes of charged particle radiotherapy, there is room for further improvement, and much remains to be learned about normal and cancer cell responses to charged particle radiation.

  11. Hollow Gaussian beam generation through nonlinear interaction of photons with orbital angular momentum

    NASA Astrophysics Data System (ADS)

    Chaitanya, N. Apurv; Jabir, M. V.; Banerji, J.; Samanta, G. K.

    2016-09-01

    Hollow Gaussian beams (HGB) are a special class of doughnut shaped beams that do not carry orbital angular momentum (OAM). Such beams have a wide range of applications in many fields including atomic optics, bio-photonics, atmospheric science, and plasma physics. Till date, these beams have been generated using linear optical elements. Here, we show a new way of generating HGBs by three-wave mixing in a nonlinear crystal. Based on nonlinear interaction of photons having OAM and conservation of OAM in nonlinear processes, we experimentally generated ultrafast HGBs of order as high as 6 and power >180 mW at 355 nm. This generic concept can be extended to any wavelength, timescales (continuous-wave and ultrafast) and any orders. We show that the removal of azimuthal phase of vortices does not produce Gaussian beam. We also propose a new and only method to characterize the order of the HGBs.

  12. Hollow Gaussian beam generation through nonlinear interaction of photons with orbital angular momentum

    PubMed Central

    Chaitanya, N. Apurv; Jabir, M. V.; Banerji, J.; Samanta, G. K.

    2016-01-01

    Hollow Gaussian beams (HGB) are a special class of doughnut shaped beams that do not carry orbital angular momentum (OAM). Such beams have a wide range of applications in many fields including atomic optics, bio-photonics, atmospheric science, and plasma physics. Till date, these beams have been generated using linear optical elements. Here, we show a new way of generating HGBs by three-wave mixing in a nonlinear crystal. Based on nonlinear interaction of photons having OAM and conservation of OAM in nonlinear processes, we experimentally generated ultrafast HGBs of order as high as 6 and power >180 mW at 355 nm. This generic concept can be extended to any wavelength, timescales (continuous-wave and ultrafast) and any orders. We show that the removal of azimuthal phase of vortices does not produce Gaussian beam. We also propose a new and only method to characterize the order of the HGBs. PMID:27581625

  13. Analytical considerations of beam hardening in medical accelerator photon spectra.

    PubMed

    Kleinschmidt, C

    1999-09-01

    Beam hardening is a well-known phenomenon for therapeutic accelerator beams passing through matter in narrow beam geometry. This study assesses quantitatively the magnitude of beam hardening of therapeutic beams in water. A formal concept of beam hardening is proposed which is based on the decrease of the mean attenuation coefficient with depth. On the basis of this concept calculations of beam hardening effects are easily performed by means of a commercial spreadsheet program. Published accelerator spectra and the tabulated values of attenuation coefficients serve as input for these calculations. It is shown that the mean attenuation coefficient starts at depth zero with an almost linear decrease and then slowly levels off to a limit value. A similar behavior is found for the beam hardening coefficient. A physically reasonable, semianalytical model is given which fits the data better than previously published functions. The energy dependence of the initial attenuation coefficient is evaluated and shown. It fits well to published experimental data. The initial beam hardening coefficient, however, shows no energy dependence. Its mean value (eta0) approximately 0.006 cm(-1)) is also in close agreement to the measured data.

  14. Surface dose measurements and comparison of unflattened and flattened photon beams

    PubMed Central

    Sigamani, Ashokkumar; Nambiraj, Arunai; Yadav, Girigesh; Giribabu, Ananda; Srinivasan, Karthikeyan; Gurusamy, Venkadamanickam; Raman, Kothanda; Karunakaran, Kaviarasu; Thiyagarajan, Rajesh

    2016-01-01

    The purpose of this study was to evaluate the central axis dose in the build-up region and the surface dose of a 6 MV and 10 MV flattened photon beam (FB) and flattening filter free (FFF) therapeutic photon beam for different square field sizes (FSs) for a Varian Truebeam linear accelerator using parallel-plate ionization chamber and Gafchromic film. Knowledge of dosimetric characteristics in the build-up region and surface dose of the FFF is essential for clinical care. The dose measurements were also obtained empirically using two different commonly used dosimeters: a p-type photon semiconductor dosimeter and a cylindrical ionization chamber. Surface dose increased linearly with FS for both FB and FFF photon beams. The surface dose values of FFF were higher than the FB FSs. The measured surface dose clearly increases with increasing FS. The FFF beams have a modestly higher surface dose in the build-up region than the FB. The dependence of source to skin distance (SSD) is less significant in FFF beams when compared to the flattened beams at extended SSDs. PMID:27217619

  15. Beam hardening artefacts in computed tomography with photon counting, charge integrating and energy weighting detectors: a simulation study.

    PubMed

    Shikhaliev, Polad M

    2005-12-21

    Photon counting x-ray imaging provides efficient rejection of the electronics noise, no pulse height (Swank) noise, less noise due to optimal photon energy weighting and the possibility of energy resolved image acquisition. These advantages apply also to CT when projection data are acquired using a photon counting detector. However, photon counting detectors assign a weighting factor of 1 to all detected photons whereas the weighting factor of a charge integrating detector is proportional to the energy of the detected photon. Therefore, data collected by photon counting and charge integrating detectors represent the 'hardening' of the photon beam passed through the object differently. This affects the beam hardening artefacts in the reconstructed CT images. This work represents the first comparative evaluation of the effect of photon counting, charge integrating and energy weighting photon detectors on beam hardening artefacts in CT. Beam hardening artefacts in CT images were evaluated for 20 cm and 14 cm diameter water cylinders with bone and low contrast inserts, at 120 kVp and 90 kVp x-ray tube voltages, respectively. It was shown that charge integrating results in 1.8% less beam hardening artefacts from bone inserts (i.e., CT numbers in the 'shadow' of the bone are less by 1.8% as compared to CT numbers over the periphery of the image), as compared to photon counting. However, optimal photon energy weighting, which provides highest SNR, results in 7.7% higher beam hardening artefacts from bone inserts as compared to photon counting. The magnitude of the 'cupping' artefacts was lower by 1% for charge integrating and higher by 6.1% for energy weighting acquisitions as compared to photon counting. Only the photon counting systems provide an accurate representation of the beam hardening effect due to its flat energy weighting. Because of their energy dependent weighting factors, the charge integrating and energy weighting systems do not provide accurate

  16. Photodynamic therapy by in situ nonlinear photon conversion

    NASA Astrophysics Data System (ADS)

    Kachynski, A. V.; Pliss, A.; Kuzmin, A. N.; Ohulchanskyy, T. Y.; Baev, A.; Qu, J.; Prasad, P. N.

    2014-06-01

    In photodynamic therapy, light is absorbed by a therapy agent (photosensitizer) to generate reactive oxygen, which then locally kills diseased cells. Here, we report a new form of photodynamic therapy in which nonlinear optical interactions of near-infrared laser radiation with a biological medium in situ produce light that falls within the absorption band of the photosensitizer. The use of near-infrared radiation, followed by upconversion to visible or ultraviolet light, provides deep tissue penetration, thus overcoming a major hurdle in treatment. By modelling and experiment, we demonstrate activation of a known photosensitizer, chlorin e6, by in situ nonlinear optical upconversion of near-infrared laser radiation using second-harmonic generation in collagen and four-wave mixing, including coherent anti-Stokes Raman scattering, produced by cellular biomolecules. The introduction of coherent anti-Stokes Raman scattering/four-wave mixing to photodynamic therapy in vitro increases the efficiency by a factor of two compared to two-photon photodynamic therapy alone, while second-harmonic generation provides a fivefold increase.

  17. In situ synchrotron x-ray photon beam characterization

    SciTech Connect

    Kyele, Nicholas R.; Silfhout, Roelof G. van; Manolopoulos, Spyros; Nikitenko, S.

    2007-03-15

    We have investigated two in situ methods of measuring x-ray beam parameters such as integrated intensity, position, and intensity distribution. These virtually transparent methods both rely on the collection of scattered radiation from a thin amorphous foil. The scattered radiation is collected by an active pixel sensor placed below the foil, well out of the direction of the beam path. These methods measure a cross-sectional image of the beam as opposed to a profile or beam centroid position provided by existing in situ detection methods. We present the results of measurements taken at a third generation synchrotron radiation source and provide analytical methods of deriving beam profile, position, and absolute intensity.

  18. Generation of highly confined optical bottle beams by exploiting the photonic nanojet effect

    NASA Astrophysics Data System (ADS)

    Kim, Myun-Sik; Scharf, Toralf; Mühlig, Stefan; Rockstuhl, Carsten; Herzig, Hans Peter

    2012-03-01

    We report on the generation of photonic nanojets, which resemble optical bottle beams. They are realized by manipulating the illumination of dielectric microspheres. As illumination we use the outer region of deliberately truncated Bessel-Gauss beam or a focused Gaussian beam with intentionally induced spherical aberrations. For the Bessel-Gauss beam possessing a single side lobe only, the nanojet spot resembles an optical bottle beam with a strong confinement due to the nanojet effect. When multiple side lobes of the aberrated focal spot are used, a chain of 3D optical bottle beams appears. We show the 3D intensity distributions close to the spot and discuss the main characteristics of such optical bottle beams.

  19. Compact beam splitters with deep gratings for miniature photonic integrated circuits: design and implementation aspects.

    PubMed

    Chen, Chin-Hui; Klamkin, Jonathan; Nicholes, Steven C; Johansson, Leif A; Bowers, John E; Coldren, Larry A

    2009-09-01

    We present an extensive study of an ultracompact grating-based beam splitter suitable for photonic integrated circuits (PICs) that have stringent density requirements. The 10 microm long beam splitter exhibits equal splitting, low insertion loss, and also provides a high extinction ratio in an integrated coherent balanced receiver. We further present the design strategies for avoiding mode distortion in the beam splitter and discuss optimization of the widths of the detectors to improve insertion loss and extinction ratio of the coherent receiver circuit. In our study, we show that the grating-based beam splitter is a competitive technology having low fabrication complexity for ultracompact PICs.

  20. A beam monitor using silicon pixel sensors for hadron therapy

    NASA Astrophysics Data System (ADS)

    Wang, Zhen; Zou, Shuguang; Fan, Yan; Liu, Jun; Sun, Xiangming; Wang, Dong; Kang, Huili; Sun, Daming; Yang, Ping; Pei, Hua; Huang, Guangming; Xu, Nu; Gao, Chaosong; Xiao, Le

    2017-03-01

    We report the design and test results of a beam monitor developed for online monitoring in hadron therapy. The beam monitor uses eight silicon pixel sensors, Topmetal-II-, as the anode array. Topmetal-II- is a charge sensor designed in a CMOS 0.35 μm technology. Each Topmetal-II- sensor has 72×72 pixels and the pixel size is 83×83 μm2. In our design, the beam passes through the beam monitor without hitting the electrodes, making the beam monitor especially suitable for monitoring heavy ion beams. This design also reduces radiation damage to the beam monitor itself. The beam monitor is tested with a carbon ion beam at the Heavy Ion Research Facility in Lanzhou (HIRFL). Results indicate that the beam monitor can measure position, incidence angle and intensity of the beam with a position resolution better than 20 μm, angular resolution about 0.5° and intensity statistical accuracy better than 2%.

  1. Applying a polynomial formula to photon beam output and equivalent square field.

    PubMed

    Chen, F S

    1990-01-01

    The polynomial formula proposed by Chen [Med. Phys. 15, 348 (1988)] in calculating the electron beam output from a Therac 20 linear accelerator has been applied to generating the output factor of various machines with photon energies ranging from 100 kVp to 18 MeV. The calculated outputs are within 1% of the measured values. This formula can be very useful to the physicist in preparing an output table of photon beams or electron beams for a therapeutic unit. An equation is derived from this formula to calculate the equivalent square. The derivation shows that only under special circumstances is the equivalent square field equivalent to 2ab/(a + b); otherwise the equivalent square field depends on the formula's parameters as well as the sides of the rectangular field. These parameters, in turn, are dependent on the photon energy, the medium irradiated, and the collimator design.

  2. Applying a polynomial formula to photon beam output and equivalent square field

    SciTech Connect

    Chen, F. )

    1990-05-01

    The polynomial formula proposed by Chen (Med. Phys. {bold 15}, 348 (1988)) in calculating the electron beam output from a Therac 20 linear accelerator has been applied to generating the output factor of various machines with photon energies ranging from 100 kVp to 18 MeV. The calculated outputs are within 1% of the measured values. This formula can be very useful to the physicist in preparing an output table of photon beams or electron beams for a therapeutic unit. An equation is derived from this formula to calculate the equivalent square. The derivation shows that only under special circumstances is the equivalent square field equivalent to 2{ital ab}/({ital a}+{ital b}); otherwise the equivalent square field depends on the formula's parameters as well as the sides of the rectangular field. These parameters, in turn, are dependent on the photon energy, the medium irradiated, and the collimator design.

  3. Signatures of light-beam spatial filtering in a three-dimensional photonic crystal

    SciTech Connect

    Maigyte, L.; Trull, J.; Cojocaru, C.; Gertus, T.; Peckus, M.; Sirutkaitis, V.; Staliunas, K.

    2010-10-15

    We report experimental evidence of spatial filtering of light beams by three-dimensional, low-refraction-index-contrast photonic crystals. The photonic crystals were fabricated in a glass bulk, where the refraction index has been periodically modulated using tightly focused femtosecond laser pulses. We observe filtered areas in the angular distributions of the transmitted radiation, and we interpret the observations by theoretical and numerical study of light propagation in index-modulated material in paraxial model.

  4. Simultaneous two-photon excitation of photodynamic therapy agents

    NASA Astrophysics Data System (ADS)

    Wachter, Eric A.; Partridge, W. P., Jr.; Fisher, Walter G.; Dees, Craig; Petersen, Mark G.

    1998-07-01

    The spectroscopic and photochemical properties of several photosensitive compounds are compared using conventional single-photon excitation (SPE) and simultaneous two-photon excitation (TPE). TPE is achieved using a mode-locked titanium:sapphire laser, the near infrared output of which allows direct promotion of non-resonant TPE. Excitation spectra and excited state properties of both type I and type II photodynamic therapy (PDT) agents are examined. In general, while SPE and TPE selection rules may be somewhat different, the excited state photochemical properties are equivalent for both modes of excitation. In vitro promotion of a two-photon photodynamic effect is demonstrated using bacterial and human breast cancer models. These results suggest that use of TPE may be beneficial for PDT, since the technique allows replacement of visible or ultraviolet excitation with non- damaging near infrared light. Further, a comparison of possible excitation sources for TPE indicates that the titanium:sapphire laser is exceptionally well suited for non- linear excitation of PDT agents in biological systems due to its extremely short pulse width and high repetition rate; these features combine to effect efficient PDT activation with minimal potential for non-specific biological damage.

  5. Three-dimensional dynamic photonic crystal creation by four laser beams interference in colloidal quantum dots

    NASA Astrophysics Data System (ADS)

    Smirnov, A. M.; Mantsevich, V. N.; Ezhova, K. V.; Tikhonov, I. V.; Dneprovskii, V. S.

    2016-04-01

    We investigate a simple way to create dynamic photonic crystals with different lattice symmetry by interference of four non-coplanar laser beams in colloidal solution of CdSe/ZnS quantum dots (QDs). The formation of dynamic photonic crystal was confirmed by the observed diffraction of the beams that have excited photonic crystal at the angles equal to that calculated for the corresponding three-dimensional lattice (self-diffraction regime). Self-diffraction from an induced 3D transient photonic crystal has been discovered in the case of resonant excitation of the excitons (electron - hole transitions) in CdSe/ZnS QDs (highly absorbing colloidal solution) by powerful beams of mode-locked laser with picosecond pulse duration. Self-diffraction arises for four laser beams intersecting in the cell with colloidal CdSe/ZnS QDs due to the induced 3D dynamic photonic crystal. The physical processes that arise in CdSe/ZnS QDs and are responsible for the observed self-action effects are discussed.

  6. Calculation of the characteristics of clinical high-energy photon beams with EGS5-MPI

    NASA Astrophysics Data System (ADS)

    Shimizu, M.; Morishita, Y.; Kato, M.; Kurosawa, T.; Tanaka, T.; Takata, N.; Saito, N.

    2014-03-01

    A graphite calorimeter has been developed as a Japanese primary standard of absorbed dose to water in the high-energy photon beams from a clinical linac. To obtain conversion factors for the graphite calorimeter, the beam characteristics of the high-energy photon beams from the clinical linac at National Metrology Institute of Japan were calculated with the EGS5 Monte Carlo simulation code. To run the EGS5 code on High Performance Computing machines that have more than 1000 CPU cores, we developed the EGS5 parallelisation package "EGS5-MPI" by implementing a message-passing interface. We calculated the photon energy spectra, which are in good agreement with those previously calculated by D. Sheikh-Bagheri and D. W. O. Rogers (Med. Phys. 29 3). We also estimated the percentage-depth-dose distributions of photon beams from the linac using the calculated photon energy spectra. These calculated percentage-depth-dose distributions were compared with our measured distributions and were found they are in good agreement as well. We will calculate conversion factors for the graphite calorimeter using our results.

  7. Genetic algorithms optimization of photonic crystal fibers for half diffraction angle reduction of output beam.

    PubMed

    Lu, Jyun-Hong; Cai, Dong-Po; Tsai, Ya-Lun; Chen, Chii-Chang; Lin, Chu-En; Yen, Ta-Jen

    2014-09-22

    In this work, we optimize the structure of the photonic crystal fibers by using genetic algorithms to provide strong light confinement in fiber and small half diffraction angle of output beam. Furthermore, this article shows the potentials of this study, such as optimizing three purposes at the same time and the arbitrary structure design is achieved. We report two optimized results obtained by different optimization conditions. The results show that the half diffraction angle of the output beam of the photonic crystal fibers can be reduced.

  8. Measurement of Electron Beam Polarization from Unstrained Bulk GaAs via Two Photon Photoemission

    SciTech Connect

    J L McCarter, T J Gay, J Hansknecht, M Poelker, M L Stutzman

    2011-06-01

    This paper describes measurements of the beam polarization and quantum efficiency for photoemission using two-photon excitation from unstrained bulk GaAs illuminated with pulsed, high intensity 1560nm laser light. Quantum efficiency is linearly proportional to 1560nm peak laser intensity, which was varied in three independent ways, indicating that the emitted electrons are promoted from the valence to the conduction band via two-photon absorption. Beam polarization was measured using a microMott polarimeter, with a value of 16.8(4)% polarization at 1560nm, which is roughly half the measured value of 33.4(8)% using 778 nm light.

  9. Nondestructive inspection of explosive materials using linearly polarized two-colored photon beam

    NASA Astrophysics Data System (ADS)

    Toyokawa, H.; Hayakawa, T.; Shizuma, T.; Hajima, R.; Masuda, K.; Ohgaki, H.

    2011-10-01

    A nondestructive inspection method for screening explosive materials that are hidden in passenger vehicles, trucks, and cargo containers with radiation shielding was presented. The method was examined experimentally using linearly polarized two-colored photon beam. A sample object was irradiated with the photon beam, followed by an emission of gamma-rays in nuclear resonance fluorescence. The gamma-rays from oxygen and nitrogen emitted through nuclear resonance fluorescence were measured using high-purity germanium detectors. We were able to evaluate the element concentration ratio.

  10. NLC Polarized Positron Photon Beam Target Thermal Structural Modeling(LCC-0087)

    SciTech Connect

    Stein, W.

    2003-10-07

    The NLC polarized positron photon beam target is a 0.4 radiation length thick titanium target. Energy deposition from one pulse occurs over 266 nano-seconds and results in heating of the target and pressure pulses straining the material. The 22.1 MeV photon beam has a spot size of 0.75 mm and results in a maximum temperature jump of 233 C. Stresses are induced in the material from thermal expansion of the hotter material. Peak effective stresses reach 19 Ksi (1.34 x 10{sup 8} Pa), which is lower than the yield strength of a titanium alloy by a factor of six.

  11. Nanophotonic ensembles for targeted multi-photon photodynamic therapy

    NASA Astrophysics Data System (ADS)

    Spangler, Charles W.; Meng, Fanqing; Gong, Aijun; Drobizhev, Mikhail A.; Karotki, Aliaksandr; Rebane, Aleksander, II

    2004-06-01

    There has been a dramatic increase in the application of new technologies for the treatment of cancerous tumors over the past decade, but for the most part, the treatment of most tumors still involves some combination of invasive surgery, chemotherapy and radiation treatments. Photodynamic therapy (PDT), which involves the activation of an administered compound with laser light followed by a series of events leading to programmed cell death of the tumor, has been proposed as a noninvasive alternative treatment to replace the standard surgery/chemotherapy/radiation protocol. However, currently approved PDT agents operate in the Visible portion of the spectrum, and laser light in this region cannot penetrate the skin more than a few millimeters. Two-photon irradiation using more highly penetrating Near-infrared (NIR) light in the tissue transparency window (700-1000 nm) has been proposed for the treatment of subcutaneous tumors, but most porphyrins exhibit extremely small two-photon cross-sections. Classical PDT also suffers from the lengthy time necessary for accumulation at the tumor site, a relative lack of discrimination between healthy and diseased tissue, particularly at the tumor margins, and difficulty in clearing from the system in a reasonable amount of time. We have recently discovered a new design paradigm for porphyrins with greatly enhanced two-photon cross-sections, and are now proposing a nano-ensemble that would also incorporate small molecule targeting agents, and possibly one-photon NIR imaging agents along with these porphyrins in one therapeutic agent. Thus these ensembles would incorporate targeting/imaging/PDT functions in one therapeutic agent, and hold the promise of single-session outpatient treatment of a large variety of subcutaneous tumors.

  12. Acceptance criteria for flattening filter-free photon beam from standard medical electron linear accelerator: AERB task group recommendations

    PubMed Central

    Sahani, G.; Sharma, S. D.; Sharma, P. K. Dash; Deshpande, D. D.; Negi, P. S.; Sathianarayanan, V. K.; Rath, G. K.

    2014-01-01

    Medical electron linear accelerators with the capability of generating unflat photon (flattening filter-free, FFF) beams are also available commercially for clinical applications in radiotherapy. However, the beam characteristics evaluation criteria and parameters are not yet available for such photon beams. Atomic Energy Regulatory Board (AERB) of India constituted a Task Group comprising experts from regulatory agency, advisory body/research and technical institutions, and clinical radiotherapy centers in the country to evolve and recommend the acceptance criteria for the flattening filter-free (FFF) photon beams. The Task Group thoroughly reviewed the literature and inputs of the manufactures/suppliers of the FFF linac and recommended a set of dosimetry parameters for evaluating the characteristics of the unflat photon beam. The recommendations included the evaluation of quality index, degree of unflatness, difference in percentage surface dose between flat and unflat photon beams, percentage depth dose at 10 cm depth, off-axis-ratios and radiation beam penumbra. The recommended parameters were evaluated for FFF photon beams generated by three different models of the linac, and it was observed that recommended evaluation methods are simple and easy to be implemented with the existing dosimetry and quality assurance infrastructure of the linac facilities of the radiotherapy departments. Recommendations were also made for periodic quality control check of the unflat photon beams and constancy evaluation in the beam characteristics. PMID:25525307

  13. Photon distribution at the output of a beam splitter for imbalanced input states

    NASA Astrophysics Data System (ADS)

    Nakazato, Hiromichi; Pascazio, Saverio; Stobińska, Magdalena; Yuasa, Kazuya

    2016-02-01

    In the Hong-Ou-Mandel interferometric scheme, two identical photons that illuminate a balanced beam splitter always leave through the same exit port. Similar effects have been predicted and (partially) experimentally confirmed for multiphoton Fock-number states. In the limit of large photon numbers, the output distribution follows a (1-x2) -1 /2 law, where x is the normalized imbalance in the output photon numbers at the two output ports. We derive an analytical formula that is also valid for imbalanced input photon numbers with a large total number of photons, and focus on the extent to which the hypothesis of perfect balanced input can be relaxed, discussing the robustness and universal features of the output distribution.

  14. A microwave beam waveguide undulator for a brilliant above 100 keV photon source.

    SciTech Connect

    Kang, Y. W.

    1999-04-19

    For generation of photons above 100-keV with a magnetic field strength in the range 0.2-0.5 Tesla, an undulator wavelength {lambda}{sub u} shorter than 5 mm may be needed with beam in the Advanced Photon Source (APS) storage ring. A microwave beam waveguide undulator system has been investigated for generation of such light. The waveguide structure consists of two parallel reflector surfaces that can be derived from an elliptically cylindrical waveguide. The structure can support deflecting TE{sub m0} modes with very low microwave loss. A microwave ring resonator circuit employing the beam waveguide is considered to construct an undulator with the above requirement. Microwave properties of the beam waveguide structure have been investigated, and the design criteria for a microwave undulator are discussed.

  15. Cascaded two-photon spectroscopy of Yb atoms with a transportable effusive atomic beam apparatus

    NASA Astrophysics Data System (ADS)

    Song, Minsoo; Yoon, Tai Hyun

    2013-02-01

    We present a transportable effusive atomic beam apparatus for cascaded two-photon spectroscopy of the dipole-forbidden transition (6s2 1S0↔ 6s7s 1S0) of Yb atoms. An ohmic-heating effusive oven is designed to have a reservoir volume of 1.6 cm3 and a high degree of atomic beam collimation angle of 30 mrad. The new atomic beam apparatus allows us to detect the spontaneously cascaded two-photons from the 6s7s1S0 state via the intercombination 6s6p3P1 state with a high signal-to-noise ratio even at the temperature of 340 °C. This is made possible in our apparatus because of the enhanced atomic beam flux and superior detection solid angle.

  16. Commissioning of a medical accelerator photon beam Monte Carlo simulation using wide-field profiles

    NASA Astrophysics Data System (ADS)

    Pena, J.; Franco, L.; Gómez, F.; Iglesias, A.; Lobato, R.; Mosquera, J.; Pazos, A.; Pardo, J.; Pombar, M.; Rodríguez, A.; Sendón, J.

    2004-11-01

    A method for commissioning an EGSnrc Monte Carlo simulation of medical linac photon beams through wide-field lateral profiles at moderate depth in a water phantom is presented. Although depth-dose profiles are commonly used for nominal energy determination, our study shows that they are quite insensitive to energy changes below 0.3 MeV (0.6 MeV) for a 6 MV (15 MV) photon beam. Also, the depth-dose profile dependence on beam radius adds an additional uncertainty in their use for tuning nominal energy. Simulated 40 cm × 40 cm lateral profiles at 5 cm depth in a water phantom show greater sensitivity to both nominal energy and radius. Beam parameters could be determined by comparing only these curves with measured data.

  17. White beam slits and pink beam slits for the hard x-ray nanoprobe beamline at the Advanced Photon Source.

    SciTech Connect

    Benson, C.; Jaski, Y.; Maser, J.; Powers, T.; Schmidt, O.; Rossi, E.

    2007-01-01

    A new type of slit has been designed for use in the hard x-ray nanoprobe beamline at the Advanced Photon Source (APS). The design incorporates monolithic GlidCop slit bodies mounted to commercially available x-y drive systems. Long, tapered apertures with adjacent water-cooling channels intercept the x-ray beam, removing the high heat load produced by two collinear APS undulators. The apertures are L-shaped and provide both horizontal and vertical slits. The beam-defining edges, positioned at the end of the tapered surfaces, consist of two sets of tungsten blades. These blades produce an exit beam with sharp corners and assure a clean cut-off for the white beam edges. The slit assembly is designed to allow overlap of the slit edges to stop the beam. The white beam slit design accommodates 3100 W of total power with a peak power density of 763 W/mm2. The pink beam slit design accommodates 400 W of total power with a peak power density of 180 W/mm2. Detailed thermal analyses were performed to verify the slits accuracy under full beam loading. The new concept allows beamline operations to 180 mA with a simplified design approach.

  18. White Beam Slits and Pink Beam Slits for the Hard X-ray Nanoprobe Beamline at the Advanced Photon Source

    SciTech Connect

    Benson, C.; Jaski, Y.; Powers, T.; Schmidt, O.; Rossi, E.; Maser, J.

    2007-01-19

    A new type of slit has been designed for use in the hard x-ray nanoprobe beamline at the Advanced Photon Source (APS). The design incorporates monolithic GlidCop slit bodies mounted to commercially available x-y drive systems. Long, tapered apertures with adjacent water-cooling channels intercept the x-ray beam, removing the high heat load produced by two collinear APS undulators. The apertures are L-shaped and provide both horizontal and vertical slits. The beam-defining edges, positioned at the end of the tapered surfaces, consist of two sets of tungsten blades. These blades produce an exit beam with sharp corners and assure a clean cut-off for the white beam edges. The slit assembly is designed to allow overlap of the slit edges to stop the beam.The white beam slit design accommodates 3100 W of total power with a peak power density of 763 W/mm2. The pink beam slit design accommodates 400 W of total power with a peak power density of 180 W/mm2. Detailed thermal analyses were performed to verify the slits' accuracy under full beam loading. The new concept allows beamline operations to 180 mA with a simplified design approach.

  19. Simulation of a 6 MV Elekta Precise Linac photon beam using GATE/GEANT4.

    PubMed

    Grevillot, L; Frisson, T; Maneval, D; Zahra, N; Badel, J-N; Sarrut, D

    2011-02-21

    The GEANT4-based GATE Monte Carlo (MC) platform was initially focused on PET and SPECT simulations. The new release v6.0 (February 2010) proposes new tools dedicated for radiation therapy simulations. In this work, we investigated some part of this extension and proposed a general methodology for Linac simulations. Details of the modeling of a 6 MV photon beam delivered by an Elekta Precise Linac, with radiation fields ranging from 5 × 5 to 30 × 30 cm(2) at the isocenter are presented. Comparisons were performed with measurements in water. The simulations were performed in two stages: first, the patient-independent part was simulated and a phase space (PhS) was built above the secondary collimator. Then, a multiple source model (MSM) derived from the PhS was proposed to simulate the photon fluence interacting with the patient-dependent part. The selective bremsstrahlung splitting (SBS) variance reduction technique proposed in GATE was used in order to speed up the accelerator head simulation. Further investigations showed that the SBS can be safely used without biasing the simulations. Additional comparisons with full simulations performed on the EGEE grid, in a single stage from the electron source to the water phantom, allowed the evaluation of the MSM. The proposed MSM allowed for calculating depth dose and transverse profiles in 48 hours on a single 2.8 GHz CPU, with a statistical uncertainty of 0.8% for a 10 × 10 cm(2) radiation field, using voxels of 5 × 5 × 5 mm(3). Good agreement between simulations and measurements in water was observed, with dose differences of about 1% and 2% for depth doses and dose profiles, respectively. Additional gamma index comparisons were performed; more than 90% of the points for all simulations passed the 3%/3 mm gamma criterion. To our knowledge, this feasibility study is the first one illustrating the potential of GATE for external radiotherapy applications.

  20. Simulation of a 6 MV Elekta Precise Linac photon beam using GATE/GEANT4

    NASA Astrophysics Data System (ADS)

    Grevillot, L.; Frisson, T.; Maneval, D.; Zahra, N.; Badel, J.-N.; Sarrut, D.

    2011-02-01

    The GEANT4-based GATE Monte Carlo (MC) platform was initially focused on PET and SPECT simulations. The new release v6.0 (February 2010) proposes new tools dedicated for radiation therapy simulations. In this work, we investigated some part of this extension and proposed a general methodology for Linac simulations. Details of the modeling of a 6 MV photon beam delivered by an Elekta Precise Linac, with radiation fields ranging from 5 × 5 to 30 × 30 cm2 at the isocenter are presented. Comparisons were performed with measurements in water. The simulations were performed in two stages: first, the patient-independent part was simulated and a phase space (PhS) was built above the secondary collimator. Then, a multiple source model (MSM) derived from the PhS was proposed to simulate the photon fluence interacting with the patient-dependent part. The selective bremsstrahlung splitting (SBS) variance reduction technique proposed in GATE was used in order to speed up the accelerator head simulation. Further investigations showed that the SBS can be safely used without biasing the simulations. Additional comparisons with full simulations performed on the EGEE grid, in a single stage from the electron source to the water phantom, allowed the evaluation of the MSM. The proposed MSM allowed for calculating depth dose and transverse profiles in 48 hours on a single 2.8 GHz CPU, with a statistical uncertainty of 0.8% for a 10 × 10 cm2 radiation field, using voxels of 5 × 5 × 5 mm3. Good agreement between simulations and measurements in water was observed, with dose differences of about 1% and 2% for depth doses and dose profiles, respectively. Additional gamma index comparisons were performed; more than 90% of the points for all simulations passed the 3%/3 mm gamma criterion. To our knowledge, this feasibility study is the first one illustrating the potential of GATE for external radiotherapy applications.

  1. Polarity correction factor for flattening filter free photon beams in several cylindrical ionization chambers.

    PubMed

    Ogata, Toshiyuki; Uehara, Kazuyuki; Nakayama, Masao; Tsudou, Shinji; Masutani, Takashi; Okayama, Takanobu

    2016-07-01

    In this study, we aimed to compare the polarity correction factor in ionization chambers for flattening filter free (FFF) photon beams and flattening filter (FF) beams. Measurements were performed with both 6 and 10 MV FFF and FF beams. Five commercial ionization chambers were evaluated: PTW TN30013; IBA Dosimetry CC01, CC04, and CC13; and Exradin A12S. Except for the CC01 ionization chamber, the other four chambers showed less than a 0.3 % difference in the polarity effect between the FFF and the FF beams. The CC01 chamber showed a strong field-size-dependence, unlike the other chambers. The polarity effect for all chambers with FFF beams did not change with the dose rate. Except in the case of the CC01 chamber, the difference in the polarity effect between FFF and FF beams was not significant.

  2. Interaction of Photon Vortex Beams with Atomic Matter

    NASA Astrophysics Data System (ADS)

    Solyanik, Maria; Afanasev, Andrei; Carlson, Carl E.

    2017-01-01

    In our work we consider helical Bessel beams' (BB's) propagation and interaction with isotropic matter. Dynamical properties of the beams with non-zero orbital angular momentum (OAM), which are determined by spatial degrees of freedom and polarization, modify the fundamental processes in light-matter interactions. Circular dichroism of BBs propagating in hydrogen gas was considered within the frame of studying the vortex beams' attenuation due to photoabsorption in hydrogen gas. In this case, the phenomenon is due to the topology of the wave front, contrary to the zero OAM case, when the change in polarization state is due to matter inhomogeneity. The effect of circular dichroism has been predicted by calculating the beam ellipticity evolution when traversing an isotropic target. According to our results, the BBs' transverse ellipticity profile has a structure of concentric circular maxima which correspond to minima of the intensity. The characteristic polarization singularity arises on the beam axis as the result of interaction with matter. It is shown, that even for the case of the paraxial approximation the effect of circular dichroism takes place. These signatures can be used for theoretical and experimental analysis of the interactions of optical vortices with atomic matter.

  3. Extended calibration range for prompt photon emission in ion beam irradiation

    NASA Astrophysics Data System (ADS)

    Bellini, F.; Boehlen, T. T.; Chin, M. P. W.; Collamati, F.; De Lucia, E.; Faccini, R.; Ferrari, A.; Lanza, L.; Mancini-Terracciano, C.; Marafini, M.; Mattei, I.; Morganti, S.; Ortega, P. G.; Patera, V.; Piersanti, L.; Russomando, A.; Sala, P. R.; Sarti, A.; Sciubba, A.; Solfaroli Camillocci, E.; Voena, C.

    2014-05-01

    Monitoring the dose delivered during proton and carbon ion therapy is still a matter of research. Among the possible solutions, several exploit the measurement of the single photon emission from nuclear decays induced by the irradiation. To fully characterize such emission the detectors need development, since the energy spectrum spans the range above the MeV that is not traditionally used in medical applications. On the other hand, a deeper understanding of the reactions involving gamma production is needed in order to improve the physic models of Monte Carlo codes, relevant for an accurate prediction of the prompt-gamma energy spectrum. This paper describes a calibration technique tailored for the range of energy of interest and reanalyzes the data of the interaction of a 80 MeV/u fully stripped carbon ion beam with a Poly-methyl methacrylate target. By adopting the FLUKA simulation with the appropriate calibration and resolution a significant improvement in the agreement between data and simulation is reported.

  4. Measurement of percentage depth dose and lateral beam profile for kilovoltage x-ray therapy beams.

    PubMed

    Li, X A; Ma, C M; Salhani, D

    1997-12-01

    In this work, nine commonly used dosimetry detectors have been investigated to determine suitable relative dosimeters for kilovoltage x-ray beams. By comparison with the Monte Carlo calculated data, it was determined that for the detectors studied the PTW N23342, Markus and NACP parallel-plate chambers are more suitable for the measurement of percentage depth dose (PDD) data for this beam quality range with an uncertainty of about 3%. A diode detector may be used to measure the PDD for the 100 kVp beam, but it is not suitable for higher energies (300 kVp). The Capintec parallel-plate chamber may be adequate for medium-energy photons, but it has a slightly higher uncertainty for low-energy x-rays (100 kVp). For the measurement of beam profiles, diode and film yield incorrect profile tails, which can be corrected using the RK ionization chamber.

  5. Modelling 6 MV photon beams of a stereotactic radiosurgery system for Monte Carlo treatment planning

    NASA Astrophysics Data System (ADS)

    Deng, Jun; Guerrero, Thomas; Ma, C.-M.; Nath, Ravinder

    2004-05-01

    The goal of this work is to build a multiple source model to represent the 6 MV photon beams from a Cyberknife stereotactic radiosurgery system for Monte Carlo treatment planning dose calculations. To achieve this goal, the 6 MV photon beams have been characterized and modelled using the EGS4/BEAM Monte Carlo system. A dual source model has been used to reconstruct the particle phase space at a plane immediately above the secondary collimator. The proposed model consists of two circular planar sources for the primary photons and the scattered photons, respectively. The dose contribution of the contaminant electrons was found to be in the order of 10-3 of the total maximum dose and therefore has been omitted in the source model. Various comparisons have been made to verify the dual source model against the full phase space simulated using the EGS4/BEAM system. The agreement in percent depth dose (PDD) curves and dose profiles between the phase space and the source model was generally within 2%/1 mm for various collimators (5 to 60 mm in diameter) at 80 to 100 cm source-to-surface distances (SSD). Excellent agreement (within 1%/1 mm) was also found between the dose distributions in heterogeneous lung and bone geometry calculated using the original phase space and those calculated using the source model. These results demonstrated the accuracy of the dual source model for Monte Carlo treatment planning dose calculations for the Cyberknife system.

  6. Two-photon polymerization of a three dimensional structure using beams with orbital angular momentum

    SciTech Connect

    Zhang, Shi-Jie; Li, Yan Liu, Zhao-Pei; Ren, Jin-Li; Xiao, Yun-Feng; Yang, Hong; Gong, Qihuang

    2014-08-11

    The focus of a beam with orbital angular momentum exhibits internal structure instead of an elliptical intensity distribution of a Gaussian beam, and the superposition of Gauss-Laguerre beams realized by two-dimensional phase modulation can generate a complex three-dimensional (3D) focus. By taking advantage of the flexibility of this 3D focus tailoring, we have fabricated a 3D microstructure with high resolution by two-photon polymerization with a single exposure. Furthermore, we have polymerized an array of double-helix structures that demonstrates optical chirality.

  7. Generation of terahertz hollow beams by a photonic quasi-crystal flat lens

    NASA Astrophysics Data System (ADS)

    Feng, Bo; Liu, Exian; Wang, Ziming; Cai, Weicheng; Liu, Hongfei; Wang, Shuo; Liang, Taiyuan; Xiao, Wei; Liu, Jianjun

    2016-06-01

    We have designed a decagonal photonic quasi-crystal (PQC) flat lens, which turns an incident terahertz (THz) plane wave into a hollow beam easily and flexibly. The features of the THz hollow beam can be controlled by varying the parameters of a point defect in the center of the lens, i.e., the PQC flat lens can be used as a flexible tool for THz optical captivity or optical tweezer. The results showing that an airy disk, whose mean beam width is similar to the incident wavelength and power-in-the-bucket (PIB) is more than 96%, can be generated in the far field.

  8. Design of the beam shut-off current monitor upgrade for the Advanced Photon Source

    SciTech Connect

    Pietryla, A.; Decker, G.

    2000-05-05

    Plans to eliminate the positron accumulator ring (PAR) from the Advanced Photon Source (APS) injector complex have created the need for a device to limit the allowable beam charge injected into the APS injector synchrotrons. The beam shut-off current monitor (BESOCM) was chosen to provide this function. This new application of the BESOCM provided the opportunity to explore new design philosophies. Two design goals were to de-emphasize reliance on external signals and to become insensitive to timing variations. Both of these goals were accomplished by deriving the trigger directly from the beam. This paper will discuss the features of the new BESOCM design and present data demonstrating its function.

  9. Dosimetry and techniques for simultaneous hyperthermia and external beam radiation therapy.

    PubMed

    Straube, W L; Klein, E E; Moros, E G; Low, D A; Myerson, R J

    2001-01-01

    An increased biological effect is realized when hyperthermia and radiation therapy are combined simultaneously. To take advantage of this effect, techniques have been developed that combine existing hyperthermia devices with a linear accelerator. This allows concomitant delivery of either ultrasound or microwave hyperthermia with photon radiation therapy. Two techniques have been used clinically: the orthogonal technique, in which the microwave or ultrasound beam and the radiation beam are orthogonal to one another, and the en face technique, in which the ultrasound or microwave beam and the radiation beam travel into the tumour through the same treatment window. The en face technique has necessitated the development of special attachments so that the hyperthermia device can be mounted to the linear accelerator and so that non-uniform portions of the hyperthermia device can be removed from the radiation beam. For microwave therapy, applicators are mounted onto the linear accelerator using the compensating filter tray holder. For ultrasound, special reflector devices are mounted to a frame that is mounted onto the compensating filter tray holder of the linear accelerator. Because the linear accelerator is an isocentric device, the height of the radiation source is fixed, and this has necessitated specially designed devices so that the ultrasound support system is compatible with the linear accelerator. The treatment setups for both the en face technique and the orthogonal technique require the interaction of both hyperthermia and radiation therapy personnel and equipment. The dosimetry and day-to-day operations for each technique are unique. The simulation for the en face technique is much different from the simulation of a normal radiation treatment and requires the presence of a hyperthermia physicist. Also, for the en face technique, the attenuation of the microwave applicator and the thickness and attenuation of the ultrasound reflector system are taken into

  10. Is Prostate Cancer a Good Candidate for Ion Beam Therapy?

    NASA Astrophysics Data System (ADS)

    Rossi, Carl J.

    Organ-confined prostate cancer now constitutes one of the most commonly treated malignancies with ion beam therapy (IBT). Because of this, questions have been raised regarding the efficacy and cost-effectiveness of such treatment. This chapter details the clinical results obtained with both proton and carbon ion therapy, discusses ongoing clinical trials, and seeks to place IBT in the context of other technological evolutions in radiation oncology.

  11. Radiation beam therapy evolution: From X-rays to hadrons

    SciTech Connect

    Khoroshkov, V. S.

    2006-10-15

    The history of external radiation beam therapy (radiotherapy)-in particular, proton therapy (PT)-is brietly outlined. Two possible strategies in increasing the efficacy of radiotherapy are considered. The radiotherapy methods and techniques are brietly described. The possibilities of PT in providing effective treatment and the main achievements are demonstrated. The state of the art in the PT development involving the active creation of large clinical PT centers since 1990 is analyzed.

  12. Effects on the photon beam from an electromagnetic array used for patient localization and tumor tracking.

    PubMed

    Zou, Wei; Betancourt, Ricardo; Yin, Lingshu; Metz, James; Avery, Stephen; Kassaee, Alireza

    2013-05-06

    One of the main components in a Calypso 4D localization and tracking system is an electromagnetic array placed above patients that is used for target monitoring during radiation treatment. The beam attenuation and beam spoiling properties of the Calypso electromagnetic array at various beam angles were investigated. Measurements were performed on a Varian Clinac iX linear accelerator with 6 MV and 15 MV photon beams. The narrow beam attenuation properties were measured under a field size of 1 cm × 1 cm, with a photon diode placed in a cylindrical graphite buildup cap. The broad beam attenuation properties were measured under a field size of 10 cm × 10 cm, with a 0.6 cc cylindrical Farmer chamber placed in a polystyrene buildup cap. Beam spoiling properties of the array were studied by measuring depth-dose change from the array under a field size of 10 cm × 10 cm in a water-equivalent plastic phantom with an embedded Markus parallel plate chamber. Change in depth doses were measured with the array placed at distances of 2, 5, and 10 cm from the phantom surface. Narrow beam attenuation and broad beam attenuation from the array were found to be less than 2%-3% for both 6 MV and 15 MV beams at angles less than 40°, and were more pronounced at more oblique angles. Spoiling effects are appreciable at beam buildup region, but are insignificant at depths beyond dmax. Dose measurements in a QA phantom using patient IMRT and VMAT treatment plans were shown to have less than 2.5% dose difference with the Calypso array. The results indicate that the dose difference due to the placement of Calypso array is clinically insignificant.

  13. Measurement of electron beam polarization from unstrained GaAs via two-photon photoemission

    SciTech Connect

    McCarter, James L.; Afanasev, A.; Gay, T. J.; Hansknecht, John C.; Kechiantz, A.; Poelker, B. Matthew

    2014-02-01

    Two-photon absorption of 1560 nm light was used to generate polarized electron beams from unstrained GaAs photocathodes of varying thickness: 625 {mu}m, 0.32 {mu}m, and 0.18 {mu}m. For each photocathode, the degree of spin polarization of the photoemitted beam was less than 50%, contradicting earlier predictions based on simple quantum mechanical selection rules for spherically-symmetric systems but consistent with the more sophisticated model of Bhat et al. (Phys. Rev. B 71 (2005) 035209). Polarization via two-photon absorption was the highest from the thinnest photocathode sample and comparable to that obtained via one-photon absorption (using 778 nm light), with values 40.3 +- 1.0% and 42.6 +- 1.0%, respectively.

  14. Designing and Dosimetry of a Shield for Photon Fields of Radiation Therapy in Oral Cavity Cancer.

    PubMed

    Jabbari, Keyvan; Senobari, Somayeh; Roayaei, Mahnaz; Rostampour, Masoumeh

    2015-01-01

    The cancer of oral cavity is related to lesions of mucous membrane of tongue and gum that can be treated with radiation therapy. A lateral photon field can be used to treat this kind of tumor, which has a side-effect on normal tissue in the opposite side of the oral cavity. In this study the dosimetric effect of the various shields in oral cavity is evaluated. In this study, a special phantom similar to the structure of oral cavity with capability of film dosimetry was designed and constructed. The various shield slabs were made of five materials: Lead, Plexiglas, Acrylic resin, Silicon and Plaster. For irradiation, Cobalt 60 (60Co) and 6 MV photon beams were used. The film dosimetry before and after the shield was performed using GAFCHROMIC EBT2 films. The film before the shield measures the magnitude of backscattering radiation from the shield. The prescribed dose was 150 cGy. Results showed that 3 cm of the lead in both energies had the maximum absorption of radiation. The absorbed dose to opposite side of shield for 6 MV photon beams and 60Co were 21 and 32 cGy, respectively. The minimum attenuation on radiation was observed in silicon shield for which the dose of opposite side were 116 and 147 cGy for 6 MV and 60Co respectively. The maximum backscattered dose was measured 177 cGy and 219 cGy using 3 cm thickness of lead, which was quite considerable. The minimum backscattering where for acrylic resin 101 and 118 cGy for 6 MV and cobalt. In this study, it was concluded that the amount of backscattering for 3 cm Lead shield is quite considerable and increases the dose significantly. A composite layer of shield with 1-2 cm lead and 1 cm acrylic resin can have the protective effect and low backscattering radiation at the same time.

  15. Designing and Dosimetry of a Shield for Photon Fields of Radiation Therapy in Oral Cavity Cancer

    PubMed Central

    Jabbari, Keyvan; Senobari, Somayeh; Roayaei, Mahnaz; Rostampour, Masoumeh

    2015-01-01

    The cancer of oral cavity is related to lesions of mucous membrane of tongue and gum that can be treated with radiation therapy. A lateral photon field can be used to treat this kind of tumor, which has a side-effect on normal tissue in the opposite side of the oral cavity. In this study the dosimetric effect of the various shields in oral cavity is evaluated. In this study, a special phantom similar to the structure of oral cavity with capability of film dosimetry was designed and constructed. The various shield slabs were made of five materials: Lead, Plexiglas, Acrylic resin, Silicon and Plaster. For irradiation, Cobalt 60 (60Co) and 6 MV photon beams were used. The film dosimetry before and after the shield was performed using GAFCHROMIC EBT2 films. The film before the shield measures the magnitude of backscattering radiation from the shield. The prescribed dose was 150 cGy. Results showed that 3 cm of the lead in both energies had the maximum absorption of radiation. The absorbed dose to opposite side of shield for 6 MV photon beams and 60Co were 21 and 32 cGy, respectively. The minimum attenuation on radiation was observed in silicon shield for which the dose of opposite side were 116 and 147 cGy for 6 MV and 60Co respectively. The maximum backscattered dose was measured 177 cGy and 219 cGy using 3 cm thickness of lead, which was quite considerable. The minimum backscattering where for acrylic resin 101 and 118 cGy for 6 MV and cobalt. In this study, it was concluded that the amount of backscattering for 3 cm Lead shield is quite considerable and increases the dose significantly. A composite layer of shield with 1–2 cm lead and 1 cm acrylic resin can have the protective effect and low backscattering radiation at the same time. PMID:26120570

  16. Assessment of radiotherapy photon beams: A practical and low cost methodology

    NASA Astrophysics Data System (ADS)

    Reis, C. Q. M.; Nicolucci, P.

    2017-02-01

    Dosimetric properties of radiation beams used in radiotherapy are directly related to the energy spectrum produced by the treatment unit. Therefore, the development of methodologies to evaluate in a simple and accurate way the spectra of clinical beams can help establishing the quality control of the treatment. The purpose of this study is to present a practical and low cost methodology for determining primary spectra of radiotherapy photon beams from transmission measurements in attenuators of aluminum and using the method of the inverse Laplace transform. Monte Carlo simulation with PENELOPE code was used in order to evaluate and validate the reconstructed spectra by the calculation of dosimetric parameters that characterize the beam. Percentage depth dose values simulated with a 6 MV reconstructed spectrum shows maximum difference of 4.4% when compared to values measured at the corresponding clinical beam. For a 10 MV beam that difference was around 4.2%. Results obtained in this study confirm the adequacy of the proposed methodology for assessing primary photon beams produced by clinical accelerators.

  17. Laser-driven beam lines for delivering intensity modulated radiation therapy with particle beams

    NASA Astrophysics Data System (ADS)

    Hofmann, K. M.; Schell, S.; Wilkens, J. J.

    2013-07-01

    Laser-accelerated particles can provide a promising opportunity for radiation therapy of cancer. Potential advantages arise from combining a compact, cost-efficient treatment unit with the physical advantages in dose delivery of charged particle beams. We consider different dose delivery schemes and the required devices to design a possible treatment unit. The secondary radiation produced in several beam line elements remains a challenge to be addressed.

  18. Laser-driven beam lines for delivering intensity modulated radiation therapy with particle beams

    SciTech Connect

    Hofmann, K. M.; Schell, S.; Wilkens, J. J.

    2013-07-26

    Laser-accelerated particles can provide a promising opportunity for radiation therapy of cancer. Potential advantages arise from combining a compact, cost-efficient treatment unit with the physical advantages in dose delivery of charged particle beams. We consider different dose delivery schemes and the required devices to design a possible treatment unit. The secondary radiation produced in several beam line elements remains a challenge to be addressed.

  19. Photon spectra calculation for an Elekta linac beam using experimental scatter measurements and Monte Carlo techniques.

    PubMed

    Juste, B; Miro, R; Campayo, J M; Diez, S; Verdu, G

    2008-01-01

    The present work is centered in reconstructing by means of a scatter analysis method the primary beam photon spectrum of a linear accelerator. This technique is based on irradiating the isocenter of a rectangular block made of methacrylate placed at 100 cm distance from surface and measuring scattered particles around the plastic at several specific positions with different scatter angles. The MCNP5 Monte Carlo code has been used to simulate the particles transport of mono-energetic beams to register the scatter measurement after contact the attenuator. Measured ionization values allow calculating the spectrum as the sum of mono-energetic individual energy bins using the Schiff Bremsstrahlung model. The measurements have been made in an Elekta Precise linac using a 6 MeV photon beam. Relative depth and profile dose curves calculated in a water phantom using the reconstructed spectrum agree with experimentally measured dose data to within 3%.

  20. Interaction of nonthermal muon beam with electron-positron-photon plasma: A thermal field theory approach

    SciTech Connect

    Noorian, Zainab; Eslami, Parvin; Javidan, Kurosh

    2013-11-15

    Interaction of a muon beam with hot dense QED plasma is investigated. Plasma system contains electrons and positrons with Fermi-Dirac distribution and Bose-Einstein distributed photons while the beam particles have nonthermal distribution. The energy loss of the beam particles during the interaction with plasma is calculated to complete leading order of interaction in terms of the QED coupling constant using thermal field theory approach. The screening effects of the plasma are computed consistently using resummation of perturbation theory with hard thermal loop approximation according to the Braaten-Pisarski method. Time evolution of the plasma characteristics and also plasma identifications during the interaction are investigated. Effects of the nonthermal parameter of the beam distribution on the energy exchange and the evolution of plasma-beam system are also explained.

  1. A comparison of phantom scatter from flattened and flattening filter free high-energy photon beams

    SciTech Connect

    Richmond, Neil; Allen, Vince; Daniel, Jim; Dacey, Rob; Walker, Chris

    2015-04-01

    Flattening filter free (FFF) photon beams have different dosimetric properties from those of flattened beams. The aim of this work was to characterize the collimator scatter (S{sub c}) and total scatter (S{sub cp}) from 3 FFF beams of differing quality indices and use the resulting mathematical fits to generate phantom scatter (S{sub p}) data. The similarities and differences between S{sub p} of flattened and FFF beams are described. S{sub c} and S{sub cp} data were measured for 3 flattened and 3 FFF high-energy photon beams (Varian 6 and 10 MV and Elekta 6 MV). These data were fitted to logarithmic power law functions with 4 numerical coefficients. The agreement between our experimentally determined flattened beam S{sub p} and published data was within ± 1.2% for all 3 beams investigated and all field sizes from 4 × 4 to 40 × 40 cm{sup 2}. For the FFF beams, S{sub p} was only within 1% of the same flattened beam published data for field sizes between 6 × 6 and 14 × 14 cm{sup 2}. Outside this range, the differences were much greater, reaching − 3.2%, − 4.5%, and − 4.3% for the fields of 40 × 40 cm{sup 2} for the Varian 6-MV, Varian 10-MV, and Elekta 6-MV FFF beams, respectively. The FFF beam S{sub p} increased more slowly with increasing field size than that of the published and measured flattened beam of a similar reference field size quality index, i.e., there is less Phantom Scatter than that found with flattened beams for a given field size. This difference can be explained when the fluence profiles of the flattened and FFF beams are considered. The FFF beam has greatly reduced fluence off axis, especially as field size increases, compared with the flattened beam profile; hence, less scatter is generated in the phantom reaching the central axis.

  2. Design of a Compton camera for 3D prompt-γ imaging during ion beam therapy

    NASA Astrophysics Data System (ADS)

    Roellinghoff, F.; Richard, M.-H.; Chevallier, M.; Constanzo, J.; Dauvergne, D.; Freud, N.; Henriquet, P.; Le Foulher, F.; Létang, J. M.; Montarou, G.; Ray, C.; Testa, E.; Testa, M.; Walenta, A. H.

    2011-08-01

    We investigate, by means of Geant4 simulations, a real-time method to control the position of the Bragg peak during ion therapy, based on a Compton camera in combination with a beam tagging device (hodoscope) in order to detect the prompt gamma emitted during nuclear fragmentation. The proposed set-up consists of a stack of 2 mm thick silicon strip detectors and a LYSO absorber detector. The γ emission points are reconstructed analytically by intersecting the ion trajectories given by the beam hodoscope and the Compton cones given by the camera. The camera response to a polychromatic point source in air is analyzed with regard to both spatial resolution and detection efficiency. Various geometrical configurations of the camera have been tested. In the proposed configuration, for a typical polychromatic photon point source, the spatial resolution of the camera is about 8.3 mm FWHM and the detection efficiency 2.5×10-4 (reconstructable photons/emitted photons in 4π). Finally, the clinical applicability of our system is considered and possible starting points for further developments of a prototype are discussed.

  3. Field match verification during combination proton, photon, and electron therapy for oligometastatic inflammatory breast cancer

    SciTech Connect

    Amos, Richard A.; Woodward, Wendy A.

    2012-01-01

    Postmastectomy radiation therapy (PMRT) has been shown in randomized trials to improve overall survival for patients with locally advanced breast cancer. The standard PMRT clinical target volume (CTV) encompasses the chest wall and undissected regional lymphatics. Conformal isodose distributions covering the standard CTV with acceptable dose limits to normal tissue can typically be achieved with a combination of photon and electron fields. Field borders are marked on the patient's skin using a light field projection of each beam and are subsequently used to verify daily field matching clinically. Initial imaging of a patient with oligometastatic inflammatory breast cancer demonstrated direct extension of disease from the involved internal mammary lymph node chain into the anterior mediastinum as the only site of metastatic disease. The patient achieved a pathologic complete response to neoadjuvant chemotherapy and underwent mastectomy. The initial sites of gross disease, including the anterior mediastinal node was included in the CTV for PMRT, and treatment planning demonstrated a clear advantage to the inclusion of proton fields in this case. The absence of a light source on the proton delivery system that accurately projects proton field edges onto the patient's skin posed a significant challenge for daily verification of proton-to-photon and -electron field matching. Proton field-specific radiographic imaging devices were designed and used such that proton field edges could be delineated on the patient's skin and used for daily matching with photon and electron fields. Manufacture of the imaging devices was quick and inexpensive. Weekly verification of proton field alignment with the proton field delineation on the skin demonstrated agreement within 3-mm tolerance. The patient remains with no evidence of disease 18 months after completing radiation. Other patients with similar indications may benefit from multimodality radiation therapy.

  4. A Polarized High-Energy Photon Beam for Production of Exotic Mesons

    SciTech Connect

    Senderovich, Igor

    2012-01-01

    This work describes design, prototyping and testing of various components of the Jefferson Lab Hall D photon beamline. These include coherent bremsstrahlung radiators to be used in this facility for generating the photon beam, a fine resolution hodoscope for the facility's tagging spectrometer, and a photon beam position sensor for stabilizing the beam on a collimator. The principal instrumentation project was the hodoscope: its design, implementation and beam testing will be thoroughly described. Studies of the coherent bremsstrahlung radiators involved X-ray characterization of diamond crystals to identify the appropriate line of manufactured radiators and the proper techniques for thinning them to the desired specification of the beamline. The photon beam position sensor project involved completion of a designed detector and its beam test. The results of these shorter studies will also be presented. The second part of this work discusses a Monte Carlo study of a possible photo-production and decay channel in the GlueX experiment that will be housed in the Hall D facility. Specifically, the γ p → Xp → b1 π → ω π+1 π-1 channel was studied including its Amplitude Analysis. This exercise attempted to generate a possible physics signal, complete with internal angular momentum states, and be able to reconstruct the signal in the detector and find the proper set of JPC quantum numbers through an amplitude fit. Derivation of the proper set of amplitudes in the helicity basis is described, followed by a discussion of the implementation, generation of the data sets, reconstruction techniques, the amplitude fit and results of this study.

  5. SU-E-T-221: Investigation of Lower Energy (< 6 MV) Photon Beams for Cancer Radiotherapy

    SciTech Connect

    Zhang, Y; Ming, X; Feng, Y; Zhou, L; Ahmad, M; Deng, J; Nguyen, K; Griffin, M

    2014-06-01

    Purpose: To study the potential applications of the lower energy (< 6MV) photon beams in the radiotherapeutic management of pediatric cancer and lung cancer patients. Methods: Photon beams of 2, 3, 4, 5 and 6MV were first simulated with EGS4/BEAM and then used for Monte-Carlo dose calculations. For four pediatric patients with abdominal and brain lesions, six 3D-conformal radiotherapy (3DCRT) plans were generated using single photon energy (2 to 6MV) or mixed energies (3 and 6MV). Furthermore, a virtual machine of 3 and 6MV was commissioned in a treatment planning system (TPS) based on Monte-Carlo simulated data. Three IMRT plans of a lung cancer patient were generated on this virtual machine. All plans were normalized to D95% of target dose for 6MV plan and then compared in terms of integral dose and OAR sparing. Results: For the four pediatric patients, the integral dose for the 2, 3, 4 and 5MV plans increased by 9%, 5%, 3.5%, 1.7%, respectively as compared to 6MV. Almost all OARs in the 2MV plan received more than 10% more doses than 6MV. Mixed energy 3DCRT plans were of the same quality as 6MV plans. For the lung IMRT plans, both the 3MV plan and the mixed beam plan showed better OAR sparing in comparison to 6MV plan. Specifically, the maximum and mean doses to the spinal cord in the mixed energy plan were lower by 21% and 16%, respectively. Conclusion: Single lower energy photon beam was found to be inferior to 6MV in the radiotherapy of pediatric patients and lung cancer patients when the integral doses and the doses to the OARs were considered. However, mixed energy plans combining low with high energy beams showed significant OAR sparing while maintaining the same PTV coverage. Investigation with more patient data is ongoing for further confirmation.

  6. Proton beam therapy for the treatment of prostate cancer.

    PubMed

    Pugh, Thomas J; Lee, Andrew K

    2014-01-01

    Through unique physical dose deposition properties, proton beam therapy (PBT) potentiates radiation dose escalation to target tissue while minimizing radiation exposure to nontarget organs. Proton beam therapy has been used to treat prostate cancer for several decades; however, access to proton centers has been restricted to the limited number of proton centers. Because of recent enhancements in availability and treatment delivery systems, interest in PBT has been burgeoning among oncologists, industry experts, and prostate cancer patients. As a result, the importance of understanding the collective experience to date and technical aspects of PBT delivery has become increasingly important in cancer medicine. This review article is intended to discuss the fundamentals of PBT treatment, critically review the literature on PBT for localized prostate cancer, and describe the continued development of proton beam technology for the treatment of prostate cancer.

  7. On Monte Carlo modeling of megavoltage photon beams: A revisited study on the sensitivity of beam parameters

    SciTech Connect

    Chibani, Omar; Moftah, Belal; Ma, C.-M. Charlie

    2011-01-15

    Purpose: To commission Monte Carlo beam models for five Varian megavoltage photon beams (4, 6, 10, 15, and 18 MV). The goal is to closely match measured dose distributions in water for a wide range of field sizes (from 2x2 to 35x35 cm{sup 2}). The second objective is to reinvestigate the sensitivity of the calculated dose distributions to variations in the primary electron beam parameters. Methods: The GEPTS Monte Carlo code is used for photon beam simulations and dose calculations. The linear accelerator geometric models are based on (i) manufacturer specifications, (ii) corrections made by Chibani and Ma [''On the discrepancies between Monte Carlo dose calculations and measurements for the 18 MV Varian photon beam,'' Med. Phys. 34, 1206-1216 (2007)], and (iii) more recent drawings. Measurements were performed using pinpoint and Farmer ionization chambers, depending on the field size. Phase space calculations for small fields were performed with and without angle-based photon splitting. In addition to the three commonly used primary electron beam parameters (E{sub AV} is the mean energy, FWHM is the energy spectrum broadening, and R is the beam radius), the angular divergence ({theta}) of primary electrons is also considered. Results: The calculated and measured dose distributions agreed to within 1% local difference at any depth beyond 1 cm for different energies and for field sizes varying from 2x2 to 35x35 cm{sup 2}. In the penumbra regions, the distance to agreement is better than 0.5 mm, except for 15 MV (0.4-1 mm). The measured and calculated output factors agreed to within 1.2%. The 6, 10, and 18 MV beam models use {theta}=0 deg., while the 4 and 15 MV beam models require {theta}=0.5 deg. and 0.6 deg., respectively. The parameter sensitivity study shows that varying the beam parameters around the solution can lead to 5% differences with measurements for small (e.g., 2x2 cm{sup 2}) and large (e.g., 35x35 cm{sup 2}) fields, while a perfect agreement is

  8. Real-time in vivo Cherenkoscopy imaging during external beam radiation therapy.

    PubMed

    Zhang, Rongxiao; Gladstone, David J; Jarvis, Lesley A; Strawbridge, Rendall R; Jack Hoopes, P; Friedman, Oscar D; Glaser, Adam K; Pogue, Brian W

    2013-11-01

    Cherenkov radiation is induced when charged particles travel through dielectric media (such as biological tissue) faster than the speed of light through that medium. Detection of this radiation or excited luminescence during megavoltage external beam radiotherapy (EBRT) can allow emergence of a new approach to superficial dose estimation, functional imaging, and quality assurance for radiation therapy dosimetry. In this letter, the first in vivo Cherenkov images of a real-time Cherenkoscopy during EBRT are presented. The imaging system consisted of a time-gated intensified charge coupled device (ICCD) coupled with a commercial lens. The ICCD was synchronized to the linear accelerator to detect Cherenkov photons only during the 3.25-μs radiation bursts. Images of a tissue phantom under irradiation show that the intensity of Cherenkov emission is directly proportional to radiation dose, and images can be acquired at 4.7 frames/s with SNR>30. Cherenkoscopy was obtained from the superficial regions of a canine oral tumor during planned, Institutional Animal Care and Use Committee approved, conventional (therapeutically appropriate) EBRT irradiation. Coregistration between photography and Cherenkoscopy validated that Cherenkov photons were detected from the planned treatment region. Real-time images correctly monitored the beam field changes corresponding to the planned dynamic wedge movement, with accurate extent of overall beam field, and expected cold and hot regions.

  9. Preliminary studies of PQS PET detector module for dose verification of carbon beam therapy

    NASA Astrophysics Data System (ADS)

    Kim, H.-I.; An, S. Jung; Lee, C. Y.; Jo, W. J.; Min, E.; Lee, K.; Kim, Y.; Joung, J.; Chung, Y. H.

    2014-05-01

    PET imaging can be used to verify dose distributions of therapeutic particle beams such as carbon ion beams. The purpose of this study was to develop a PET detector module which was designed for an in-beam PET scanner geometry integrated into a carbon beam therapy system, and to evaluate its feasibility as a monitoring system of patient dose distribution. A C-shaped PET geometry was proposed to avoid blockage of the carbon beam by the detector modules. The proposed PET system consisted of 14 detector modules forming a bore with 30.2 cm inner diameter for brain imaging. Each detector module is composed of a 9 × 9 array of 4.0 mm × 4.0 mm × 20.0 mm LYSO crystal module optically coupled with four 29 mm diameter PMTs using Photomultiplier-quadrant-sharing (PQS) technique. Because the crystal pixel was identified based upon the distribution of scintillation lights of four PMTs, the design of the reflector between crystal elements should be well optimized. The optical design of reflectors was optimized using DETECT2000, a Monte Carlo code for light photon transport. A laser-cut reflector set was developed using the Enhanced Specular Reflector (ESR, 3M Co.) mirror-film with a high reflectance of 98% and a thickness of 0.064 mm. All 81 crystal elements of detector module were identified. Our result demonstrates that the C-shaped PET system is under development and we present the first reconstructed image.

  10. Beam-bending in spatially variant photonic crystals at telecommunications wavelengths

    NASA Astrophysics Data System (ADS)

    Digaum, Jennefir L.; Sharma, Rashi; Batista, Daniel; Pazos, Javier J.; Rumpf, Raymond C.; Kuebler, Stephen M.

    2016-03-01

    This work reports the fabrication of micron-scale spatially variant photonic crystals (SVPCs) and their use for steering light beams through turns with bending radius Rbend on the order of ten times the optical wavelength λ0. Devices based on conventional photonic crystals, metamaterials, plasmonics and transformation optics have all been explored for controlling light beams and steering them through tight turns. These devices offer promise for photonic interconnects, but they are based on exotic materials, including metals, that make them impractically lossy or difficult to fabricate. Waveguides can also be used to steer light using total internal reflection; however, Rbend of a waveguide must be hundreds of times λ0 to guide light efficiently, which limits their use in optical circuits. SVPCs are spatially variant 3D lattices which can be created in transparent, low-refractive-index media and used to control the propagation of light through the self-collimation effect. SVPCs were fabricated by multi-photon lithography using the commercially available photo-polymer IP-DIP. The SVPCs were structurally and optically characterized and found to be capable of bending light having λ0 = 1.55 μm through a 90-degree turn with Rbend = 10 μm. Curved waveguides with Rbend = 15 μm and 35 μm were also fabricated using IP-DIP and optically characterized. The SVPCs were able to steer the light beams through tighter turns than either waveguide and with higher efficiency.

  11. Experimental verification of a commercial Monte Carlo-based dose calculation module for high-energy photon beams

    NASA Astrophysics Data System (ADS)

    Künzler, Thomas; Fotina, Irina; Stock, Markus; Georg, Dietmar

    2009-12-01

    The dosimetric performance of a Monte Carlo algorithm as implemented in a commercial treatment planning system (iPlan, BrainLAB) was investigated. After commissioning and basic beam data tests in homogenous phantoms, a variety of single regular beams and clinical field arrangements were tested in heterogeneous conditions (conformal therapy, arc therapy and intensity-modulated radiotherapy including simultaneous integrated boosts). More specifically, a cork phantom containing a concave-shaped target was designed to challenge the Monte Carlo algorithm in more complex treatment cases. All test irradiations were performed on an Elekta linac providing 6, 10 and 18 MV photon beams. Absolute and relative dose measurements were performed with ion chambers and near tissue equivalent radiochromic films which were placed within a transverse plane of the cork phantom. For simple fields, a 1D gamma (γ) procedure with a 2% dose difference and a 2 mm distance to agreement (DTA) was applied to depth dose curves, as well as to inplane and crossplane profiles. The average gamma value was 0.21 for all energies of simple test cases. For depth dose curves in asymmetric beams similar gamma results as for symmetric beams were obtained. Simple regular fields showed excellent absolute dosimetric agreement to measurement values with a dose difference of 0.1% ± 0.9% (1 standard deviation) at the dose prescription point. A more detailed analysis at tissue interfaces revealed dose discrepancies of 2.9% for an 18 MV energy 10 × 10 cm2 field at the first density interface from tissue to lung equivalent material. Small fields (2 × 2 cm2) have their largest discrepancy in the re-build-up at the second interface (from lung to tissue equivalent material), with a local dose difference of about 9% and a DTA of 1.1 mm for 18 MV. Conformal field arrangements, arc therapy, as well as IMRT beams and simultaneous integrated boosts were in good agreement with absolute dose measurements in the

  12. SU-E-T-238: Deriving Electron Contamination Spectra From Pure and Clinical Photon Beams

    SciTech Connect

    Smit, C; Plessis, F du

    2015-06-15

    Purpose: To extract the electron contamination energy spectra for an Elekta Precise Linac, based on pure photon and measured clinical beam percentage depth dose data. And to include this as an additional source in isource 4 in DOSXYZnrc. Methods: A pure photon beam was simulated for the Linac using isource 4 in the DOSXYZnrc Monte Carlo (MC) code. Percentage depth dose (PDD) data were extracted afterwards for a range of field sizes (FS). These simulated dose data were compared to actual measured dose PDD data, with the data normalized at 10 cm depth. The resulting PDD data resembled the electron contamination depth dose. Since the dose fall-off is a strictly decreasing function, a method was adopted to derive the contamination electron spectrum. Afterwards this spectrum was used in a DOSXYZnrc MC simulation run to verify that the original electron depth dose could be replicated. Results: Various square aperture FS’s for 6, 8 and 15 megavolt (MV) photon beams were modeled, simulated and compared to their respective actual measured PDD data. As FS increased, simulated pure photon depth-dose profiles shifted deeper, thus requiring electron contamination to increase the surface dose. The percentage of electron weight increased with increase in FS. For a FS of 15×15 cm{sup 2}, the percentage electron weight is 0.1%, 0.2% and 0.4% for 6, 8 and 15 MV beams respectively. Conclusion: From the PDD results obtained, an additional electron contamination source was added to the photon source model so that simulation and measured PDD data could match within 2 % / 2 mm gamma-index criteria. The improved source model could assure more accurate simulations of surface doses. This research project was funded by the South African Medical Research Council (MRC) with funds from National Treasury under its Economic Competitiveness and Support package.

  13. WE-A-207-02: Electron Beam Therapy - Current Status and Future Directions

    SciTech Connect

    Wu, Q.

    2015-06-15

    In memory of the significant contribution of Dr. Jacques Ovadia to electron beam techniques, this session will review recent, advanced techniques which are reinvigorating the science of electron beam radiation therapy. Recent research efforts in improving both the applicability and quality of the electron beam therapy will be discussed, including modulated electron beam radiotherapy (MERT) and dynamic electron arc radiotherapy (DEAR). Learning Objectives: To learn about recent advances in electron beam therapy, including modulated electron beam therapy and dynamic electron arc therapy (DEAR). Put recent advances in the context of work that Dr. Ovadia pursued during his career in medical physics.

  14. Combining tissue-phantom ratios to provide a beam-quality specifier for flattening filter free photon beams

    SciTech Connect

    Dalaryd, Mårten Knöös, Tommy; Ceberg, Crister

    2014-11-01

    Purpose: There are currently several commercially available radiotherapy treatment units without a flattening filter in the beam line. Unflattened photon beams have an energy and lateral fluence distribution that is different from conventional beams and, thus, their attenuation properties differ. As a consequence, for flattening filter free (FFF) beams, the relationship between the beam-quality specifier TPR{sub 20,10} and the Spencer–Attix restricted water-to-air mass collision stopping-power ratios, (L{sup -}/ρ){sub air}{sup water}, may have to be refined in order to be used with equivalent accuracy as for beams with a flattening filter. The purpose of this work was twofold. First, to study the relationship between TPR{sub 20,10} and (L{sup -}/ρ){sub air}{sup water} for FFF beams, where the flattening filter has been replaced by a metal plate as in most clinical FFF beams. Second, to investigate the potential of increasing the accuracy in determining (L{sup -}/ρ){sub air}{sup water} by adding another beam-quality metric, TPR{sub 10,5}. The relationship between (L{sup -}/ρ){sub air}{sup water} and %dd(10){sub x} for beams with and without a flattening filter was also included in this study. Methods: A total of 24 realistic photon beams (10 with and 14 without a flattening filter) from three different treatment units have been used to calculate (L{sup -}/ρ){sub air}{sup water}, TPR{sub 20,10}, and TPR{sub 10,5} using the EGSnrc Monte Carlo package. The relationship between (L{sup -}/ρ){sub air}{sup water} and the dual beam-quality specifier TPR{sub 20,10} and TPR{sub 10,5} was described by a simple bilinear equation. The relationship between the photon beam-quality specifier %dd(10){sub x} used in the AAPM’s TG-51 dosimetry protocol and (L{sup -}/ρ){sub air}{sup water} was also investigated for the beams used in this study, by calculating the photon component of the percentage depth dose at 10 cm depth with SSD 100 cm. Results: The calculated (L{sup -}/

  15. Beam angle selection incorporation of anatomical heterogeneities for pencil beam scanning charged-particle therapy

    NASA Astrophysics Data System (ADS)

    Toramatsu, Chie; Inaniwa, Taku

    2016-12-01

    In charged particle therapy with pencil beam scanning (PBS), localization of the dose in the Bragg peak makes dose distributions sensitive to lateral tissue heterogeneities. The sensitivity of a PBS plan to lateral tissue heterogeneities can be reduced by selecting appropriate beam angles. The purpose of this study is to develop a fast and accurate method of beam angle selection for PBS. The lateral tissue heterogeneity surrounding the path of the pencil beams at a given angle was quantified with the heterogeneity number representing the variation of the Bragg peak depth across the cross section of the beams using the stopping power ratio of body tissues with respect to water. To shorten the computation time, one-dimensional dose optimization was conducted along the central axis of the pencil beams as they were directed by the scanning magnets. The heterogeneity numbers were derived for all possible beam angles for treatment. The angles leading to the minimum mean heterogeneity number were selected as the optimal beam angle. Three clinical cases of head and neck cancer were used to evaluate the developed method. Dose distributions and their robustness to setup and range errors were evaluated for all tested angles, and their relation to the heterogeneity numbers was investigated. The mean heterogeneity number varied from 1.2 mm-10.6 mm in the evaluated cases. By selecting a field with a low mean heterogeneity number, target dose coverage and robustness against setup and range errors were improved. The developed method is simple, fast, accurate and applicable for beam angle selection in charged particle therapy with PBS.

  16. First experimental-based characterization of oxygen ion beam depth dose distributions at the Heidelberg Ion-Beam Therapy Center

    NASA Astrophysics Data System (ADS)

    Kurz, C.; Mairani, A.; Parodi, K.

    2012-08-01

    Over the last decades, the application of proton and heavy-ion beams to external beam radiotherapy has rapidly increased. Due to the favourable lateral and depth dose profile, the superposition of narrow ion pencil beams may enable a highly conformal dose delivery to the tumour, with better sparing of the surrounding healthy tissue in comparison to conventional radiation therapy with photons. To fully exploit the promised clinical advantages of ion beams, an accurate planning of the patient treatments is required. The clinical treatment planning system (TPS) at the Heidelberg Ion-Beam Therapy Center (HIT) is based on a fast performing analytical algorithm for dose calculation, relying, among others, on laterally integrated depth dose distributions (DDDs) simulated with the FLUKA Monte Carlo (MC) code. Important input parameters of these simulations need to be derived from a comparison of the simulated DDDs with measurements. In this work, the first measurements of 16O ion DDDs at HIT are presented with a focus on the determined Bragg peak positions and the understanding of factors influencing the shape of the distributions. The measurements are compared to different simulation approaches aiming to reproduce the acquired data at best. A simplified geometrical model is first used to optimize important input parameters, not known a priori, in the simulations. This method is then compared to a more realistic, but also more time-consuming simulation approach better accounting for the experimental set-up and the measuring process. The results of this work contributed to a pre-clinical oxygen ion beam database, which is currently used by a research TPS for corresponding radio-biological cell experiments. A future extension to a clinical database used by the clinical TPS at HIT is foreseen. As a side effect, the performed investigations showed that the typical water equivalent calibration approach of experimental data acquired with water column systems leads to slight

  17. Compact terahertz wave polarization beam splitter using photonic crystal.

    PubMed

    Mo, Guo-Qiang; Li, Jiu-Sheng

    2016-09-01

    Electromagnetic polarization conveys valuable information for signal processing. Manipulation of a terahertz wave polarization state exhibits tremendous potential in developing applications of terahertz science and technology. We propose an approach to efficiently split transverse-electric and transverse-magnetic polarized terahertz waves into different propagation directions over the frequency range from 0.9998 to 1.0007 THz. Both the plane wave expansion method and the finite-difference time-domain method are used to calculate and analyze the transmission characteristics of the proposed device. The present device is very compact and the total size is 1.02  mm×0.99  mm. This polarization beam splitter performance indicates that the structure has a potential application for forthcoming terahertz-wave integrated circuit fields.

  18. Two-photon excitation photodynamic therapy with Photofrin

    NASA Astrophysics Data System (ADS)

    Karotki, Aliaksandr; Khurana, Mamta; Lepock, James R.; Wilson, Brian C.

    2005-09-01

    Photodynamic therapy (PDT) based on simultaneous two-photon (2-γ) excitation has a potential advantage of highly targeted treatment by means of nonlinear localized photosensitizer excitation. One of the possible applications of 2-γ PDT is a treatment of exodus age-related macular degeneration where highly targeted excitation of photosensitizer in neovasculature is vital for reducing collateral damage to healthy surrounding tissue. To investigate effect of 2-γ PDT Photofrin was used as an archetypal photosensitizer. First, 2-γ absorption properties of Photofrin in the 750 - 900 nm excitation wavelength range were investigated. It was shown that above 800 nm 2-γ interaction was dominant mode of excitation. The 2-γ cross section of Photofrin was rather small and varied between 5 and 10 GM (1 GM = 10-50 cm4s/photon) in this wavelength range. Next, endothelial cells treated with Photofrin were used to model initial effect of 2-γ PDT on neovasculature. Ultrashort laser pulses provided by mode-locked Ti:sapphire laser (pulse duration at the sample 300 fs, repetition rate 90 MHz, mean laser power 10 mW, excitation wavelength 850 nm) were used for the excitation of the photosensitizer. Before 2-γ excitation of the Photofrin cells formed a single continuous sheet at the bottom of the well. The tightly focused laser light was scanned repeatedly over the cell layer. After irradiation the cell layer of the control cells stayed intact while cells treated with photofrin became clearly disrupted. The light doses required were high (6300 Jcm(-2) for ~ 50% killing), but 2-γ cytotoxicity was unequivocally demonstrated.

  19. Peripheral photon and neutron doses from prostate cancer external beam irradiation.

    PubMed

    Bezak, Eva; Takam, Rundgham; Marcu, Loredana G

    2015-12-01

    Peripheral photon and neutron doses from external beam radiotherapy (EBRT) are associated with increased risk of carcinogenesis in the out-of-field organs; thus, dose estimations of secondary radiation are imperative. Peripheral photon and neutron doses from EBRT of prostate carcinoma were measured in Rando phantom. (6)LiF:Mg,Cu,P and (7)LiF:Mg,Cu,P glass-rod thermoluminescence dosemeters (TLDs) were inserted in slices of a Rando phantom followed by exposure to 80 Gy with 18-MV photon four-field 3D-CRT technique. The TLDs were calibrated using 6- and 18-MV X-ray beam. Neutron dose equivalents measured with CR-39 etch-track detectors were used to derive readout-to-neutron dose conversion factor for (6)LiF:Mg,Cu,P TLDs. Average neutron dose equivalents per 1 Gy of isocentre dose were 3.8±0.9 mSv Gy(-1) for thyroid and 7.0±5.4 mSv Gy(-1) for colon. For photons, the average dose equivalents per 1 Gy of isocentre dose were 0.2±0.1 mSv Gy(-1) for thyroid and 8.1±9.7 mSv Gy(-1) for colon. Paired (6)LiF:Mg,Cu,P and (7)LiF:Mg,Cu,P TLDs can be used to measure photon and neutron doses simultaneously. Organs in close proximity to target received larger doses from photons than those from neutrons whereas distally located organs received higher neutron versus photon dose.

  20. An analytical formalism to calculate phantom scatter factors for flattening filter free (FFF) mode photon beams.

    PubMed

    Chung, Heeteak; Prado, Karl L; Yi, Byong Yong

    2014-02-21

    Phantom Scatter Factors, Sp in the Khan formalism (Khan et al 1980 J. Radiat. Oncol. Biol. Phys. 6 745-51) describe medium-induced changes in photon-beam intensity as a function of size of the beam. According to the British Journal of Radiology, Supplement 25, megavoltage phantom scatter factors are invariant as a function of photon-beam energy. However, during the commissioning of an accelerator with flattening filter free (FFF) photon beams (Varian TrueBeam(TM) 6-MV FFF and 10-MV FFF), differences were noted in phantom scatter between the filtered beams and FFF-mode beams. The purpose of this work was to evaluate this difference and provide an analytical formalism to explain the phantom scatter differences between FFF-mode and the filtered mode. An analytical formalism was devised to demonstrate the source of phantom scatter differences between the filtered and the FFF-mode beams. The reason for the differences in the phantom scatter factors between the filtered and the FFF-mode beams is hypothesized to be the non-uniform beam profiles of the FFF-mode beams. The analytical formalism proposed here is based on this idea, taking the product of the filtered phantom scatter factors and the ratio of the off-axis ratio between the FFF-mode and the filtered beams. All measurements were performed using a Varian TrueBeam(TM) linear accelerator with photon energies of 6-MV and 10-MV in both filtered and FFF-modes. For all measurements, a PTW Farmer type chamber and a Scanditronix CC04 cylindrical ionization were used. The in-water measurements were made at depth dose maximum and 100 cm source-to-axis distance. The in-air measurements were done at 100 cm source-to-axis distance with appropriate build-up cap. From these measurements, the phantom scatter factors were derived for the filtered beams and the FFF-mode beams for both energies to be evaluated against the phantoms scatter factors calculated using the proposed algorithm. For 6-MV, the difference between the measured

  1. Analysis of a photonic nanojet assuming a focused incident beam instead of a plane wave

    NASA Astrophysics Data System (ADS)

    Dong, Aotuo; Su, Chin

    2014-12-01

    The analysis of a photonic nanojet formed by dielectric spheres almost always assumes that the incident field is a plane wave. In this work, using vector spherical harmonics representations, we analyze the case of a more realistic incident field consisting of a focused beam formed by a microscope objective. Also included is the situation in which the sphere is not at the focal plane of the focus beam. We find that the dimension of the nanojet beam waist is less sensitive with respect to the azimuthal angle when compared with the plane wave case. Also, by shifting the particle away from the focal plane, the nanojet beam waist can be positioned outside the particle which otherwise would be inside or at the particle surface. Inherently, no such adjustment is possible with an incident plane wave assumption.

  2. Nano-scale processes behind ion-beam cancer therapy

    NASA Astrophysics Data System (ADS)

    Surdutovich, Eugene; Garcia, Gustavo; Mason, Nigel; Solov'yov, Andrey V.

    2016-04-01

    This topical issue collates a series of papers based on new data reported at the third Nano-IBCT Conference of the COST Action MP1002: Nanoscale Insights into Ion Beam Cancer Therapy, held in Boppard, Germany, from October 27th to October 31st, 2014. The Nano-IBCT COST Action was launched in December 2010 and brought together more than 300 experts from different disciplines (physics, chemistry, biology) with specialists in radiation damage of biological matter from hadron-therapy centres, and medical institutions. This meeting followed the first and the second conferences of the Action held in October 2011 in Caen, France and in May 2013 in Sopot, Poland respectively. This conference series provided a focus for the European research community and has highlighted the pioneering research into the fundamental processes underpinning ion beam cancer therapy. Contribution to the Topical Issue "COST Action Nano-IBCT: Nano-scale Processes Behind Ion-Beam Cancer Therapy", edited by Andrey V. Solov'yov, Nigel Mason, Gustavo Garcia and Eugene Surdutovich.

  3. Sparing of tissue by using micro-slit-beam radiation therapy reduces neurotoxicity compared with broad-beam radiation therapy

    PubMed Central

    Mukumoto, Naritoshi; Nakayama, Masao; Akasaka, Hiroaki; Shimizu, Yasuyuki; Osuga, Saki; Miyawaki, Daisuke; Yoshida, Kenji; Ejima, Yasuo; Miura, Yasushi; Umetani, Keiji; Kondoh, Takeshi; Sasaki, Ryohei

    2017-01-01

    Micro-slit-beam radiation therapy (MRT) using synchrotron-generated X-ray beams allows for extremely high-dose irradiation. However, the toxicity of MRT in central nervous system (CNS) use is still unknown. To gather baseline toxicological data, we evaluated mortality in normal mice following CNS-targeted MRT. Male C57BL/6 J mice were head-fixed in a stereotaxic frame. Synchrotron X-ray-beam radiation was provided by the SPring-8 BL28B2 beam-line. For MRT, radiation was delivered to groups of mice in a 10 × 12 mm unidirectional array consisting of 25-μm-wide beams spaced 100, 200 or 300 μm apart; another group of mice received the equivalent broad-beam radiation therapy (BRT) for comparison. Peak and valley dose rates of the MRT were 120 and 0.7 Gy/s, respectively. Delivered doses were 96–960 Gy for MRT, and 24–120 Gy for BRT. Mortality was monitored for 90 days post-irradiation. Brain tissue was stained using hematoxylin and eosin to evaluate neural structure. Demyelination was evaluated by Klüver–Barrera staining. The LD50 and LD100 when using MRT were 600 Gy and 720 Gy, respectively, and when using BRT they were 80 Gy and 96 Gy, respectively. In MRT, mortality decreased as the center-to-center beam spacing increased from 100 μm to 300 μm. Cortical architecture was well preserved in MRT, whereas BRT induced various degrees of cerebral hemorrhage and demyelination. MRT was able to deliver extremely high doses of radiation, while still minimizing neuronal death. The valley doses, influenced by beam spacing and irradiated dose, could represent important survival factors for MRT. PMID:27422939

  4. Dosimetric effects on small-field beam-modeling for stereotactic body radiation therapy

    NASA Astrophysics Data System (ADS)

    Cho, Woong; Kim, Suzy; Kim, Jung-In; Wu, Hong-Gyun; Jung, Joo-Young; Kim, Min-Joo; Suh, Tae-Suk; Kim, Jin-Young; Kim, Jong Won

    2015-02-01

    The treatment planning of stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT) requires high accuracy of dosimetric data for small radiation fields. The dosimetric effects on the beam-modeling process of a treatment planning system (TPS) were investigated using different measured small-field data sets. We performed small-field dosimetry with three detectors: a CC13 ion chamber, a CC01 ion chamber, and an edge detector. Percentage depth doses (PDDs) and dose profiles for field sizes given by 3 × 3 cm2, 2 × 2 cm2, and 1 × 1 cm2 were obtained for 6 MV and 15 MV photon beams. Each measured data set was used as data input for a TPS, in which a beam-modeling process was implemented using the collapsed cone convolution (CCC) algorithm for dose calculation. The measured data were used to generate six beam-models based on each combination of detector type and photon energy, which were then used to calculate the corresponding PDDs and dose profiles for various depths and field sizes. Root mean square differences (RMSDs) between the calculated and the measured doses were evaluated for the PDDs and the dose profiles. The RMSDs of PDDs beyond the maximum dose depth were within an accuracy of 0.2-0.6%, being clinically acceptable. The RMSDs of the dose profiles corresponding to the CC13, the CC01, and the edge detector were 2.80%, 1.49%, and 1.46% for a beam energy of 6 MV and 2.34%, 1.15%, and 1.44% for a beam energy of 15 MV, respectively. The calculated results for the CC13 ion chamber showed the most discrepancy compared to the measured data, due to the relatively large sensitive volume of this detector. However, the calculated dose profiles for the detectors were not significantly different from another. The physical algorithm used in the beam-modeling process did not seem to be sensitive to blurred data measured with detectors with large sensitive volumes. Each beam-model was used to clinically evaluate lung and lymphatic node SBRT plans

  5. 21 CFR 892.5710 - Radiation therapy beam-shaping block.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Radiation therapy beam-shaping block. 892.5710... (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES Therapeutic Devices § 892.5710 Radiation therapy beam-shaping block. (a) Identification. A radiation therapy beam-shaping block is a device made of a...

  6. 21 CFR 892.5710 - Radiation therapy beam-shaping block.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Radiation therapy beam-shaping block. 892.5710... (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES Therapeutic Devices § 892.5710 Radiation therapy beam-shaping block. (a) Identification. A radiation therapy beam-shaping block is a device made of a...

  7. 21 CFR 892.5710 - Radiation therapy beam-shaping block.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Radiation therapy beam-shaping block. 892.5710... (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES Therapeutic Devices § 892.5710 Radiation therapy beam-shaping block. (a) Identification. A radiation therapy beam-shaping block is a device made of a...

  8. 21 CFR 892.5710 - Radiation therapy beam-shaping block.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Radiation therapy beam-shaping block. 892.5710... (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES Therapeutic Devices § 892.5710 Radiation therapy beam-shaping block. (a) Identification. A radiation therapy beam-shaping block is a device made of a...

  9. 21 CFR 892.5710 - Radiation therapy beam-shaping block.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Radiation therapy beam-shaping block. 892.5710... (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES Therapeutic Devices § 892.5710 Radiation therapy beam-shaping block. (a) Identification. A radiation therapy beam-shaping block is a device made of a...

  10. Laser-driven beam lines for delivering intensity modulated radiation therapy with particle beams

    PubMed Central

    Hofmann, Kerstin M; Schell, Stefan; Wilkens, Jan J

    2012-01-01

    Abstract Laser-accelerated particles are a promising option for radiation therapy of cancer by potentially combining a compact, cost-efficient treatment unit with the physical advantages of charged particle beams. To design such a treatment unit we consider different dose delivery schemes and analyze the necessary devices in the required particle beam line for each case. Furthermore, we point out that laser-driven treatment units may be ideal tools for motion adaptation during radiotherapy. Reasons for this are the potential of a flexible gantry and the time structure of the beam with high particle numbers in ultrashort bunches. One challenge that needs to be addressed is the secondary radiation produced in several beam line elements. (© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) PMID:22930653

  11. Laser-driven beam lines for delivering intensity modulated radiation therapy with particle beams.

    PubMed

    Hofmann, Kerstin M; Schell, Stefan; Wilkens, Jan J

    2012-11-01

    Laser-accelerated particles are a promising option for radiation therapy of cancer by potentially combining a compact, cost-efficient treatment unit with the physical advantages of charged particle beams. To design such a treatment unit we consider different dose delivery schemes and analyze the necessary devices in the required particle beam line for each case. Furthermore, we point out that laser-driven treatment units may be ideal tools for motion adaptation during radiotherapy. Reasons for this are the potential of a flexible gantry and the time structure of the beam with high particle numbers in ultrashort bunches. One challenge that needs to be addressed is the secondary radiation produced in several beam line elements.

  12. Monte Carlo-based energy response studies of diode dosimeters in radiotherapy photon beams.

    PubMed

    Arun, C; Palani Selvam, T; Dinkar, Verma; Munshi, Prabhat; Kalra, Manjit Singh

    2013-01-01

    This study presents Monte Carlo-calculated absolute and normalized (relative to a (60)Co beam) sensitivity values of silicon diode dosimeters for a variety of commercially available silicon diode dosimeters for radiotherapy photon beams in the energy range of (60)Co-24 MV. These values were obtained at 5 cm depth along the central axis of a water-equivalent phantom of 10 cm × 10 cm field size. The Monte Carlo calculations were based on the EGSnrc code system. The diode dosimeters considered in the calculations have different buildup materials such as aluminum, brass, copper, and stainless steel + epoxy. The calculated normalized sensitivity values of the diode dosimeters were then compared to previously published measured values for photon beams at (60)Co-20 MV. The comparison showed reasonable agreement for some diode dosimeters and deviations of 5-17 % (17 % for the 3.4 mm brass buildup case for a 10 MV beam) for some diode dosimeters. Larger deviations of the measurements reflect that these models of the diode dosimeter were too simple. The effect of wall materials on the absorbed dose to the diode was studied and the results are presented. Spencer-Attix and Bragg-Gray stopping power ratios (SPRs) of water-to-diode were calculated at 5 cm depth in water. The Bragg-Gray SPRs of water-to-diode compare well with Spencer-Attix SPRs for ∆ = 100 keV and above at all beam qualities.

  13. One- and two-photon absorption in solution: The effects of a passive auxiliary beam

    SciTech Connect

    Ford, J. S.; Andrews, D. L.

    2014-07-21

    The efficiencies of one- and two-photon absorption by chromophores in solution may be significantly modified by a sufficiently intense beam of off-resonant light. A molecular analysis based on quantum electrodynamics (QED) fully accounts for this phenomenon of laser-modified absorption. A time-dependent perturbation-theory treatment describes the process in terms of stimulated forward Rayleigh-scattering of the auxiliary beam occurring simultaneously with the absorption interaction(s). Our formulation accommodates media modifications to the basic character of light-matter interactions, taking into account the refractive and dispersive properties of a solution-phase environment. This introduces the bulk refractive index of the solvent directly into the QED framework. The measurable electronic response of molecules freely rotating in solution is defined by an average of all orientations. We explicitly derive fixed-orientation and rotationally averaged calculations for the Fermi-rule rate of laser-modified one- and two-photon absorption. For a given beam polarization geometry, the solution-phase molecular response is expressible as a set of natural invariant scalars. These results reveal details of the dependence on the beam polarisations and on the rotationally averaged molecular response: we illustrate the breadth of variation available via geometric manipulation of beam polarization, and raise new possibilities for quantum weak measurements of laser states.

  14. One- and two-photon absorption in solution: the effects of a passive auxiliary beam.

    PubMed

    Ford, J S; Andrews, D L

    2014-07-21

    The efficiencies of one- and two-photon absorption by chromophores in solution may be significantly modified by a sufficiently intense beam of off-resonant light. A molecular analysis based on quantum electrodynamics (QED) fully accounts for this phenomenon of laser-modified absorption. A time-dependent perturbation-theory treatment describes the process in terms of stimulated forward Rayleigh-scattering of the auxiliary beam occurring simultaneously with the absorption interaction(s). Our formulation accommodates media modifications to the basic character of light-matter interactions, taking into account the refractive and dispersive properties of a solution-phase environment. This introduces the bulk refractive index of the solvent directly into the QED framework. The measurable electronic response of molecules freely rotating in solution is defined by an average of all orientations. We explicitly derive fixed-orientation and rotationally averaged calculations for the Fermi-rule rate of laser-modified one- and two-photon absorption. For a given beam polarization geometry, the solution-phase molecular response is expressible as a set of natural invariant scalars. These results reveal details of the dependence on the beam polarisations and on the rotationally averaged molecular response: we illustrate the breadth of variation available via geometric manipulation of beam polarization, and raise new possibilities for quantum weak measurements of laser states.

  15. One- and two-photon absorption in solution: The effects of a passive auxiliary beam

    NASA Astrophysics Data System (ADS)

    Ford, J. S.; Andrews, D. L.

    2014-07-01

    The efficiencies of one- and two-photon absorption by chromophores in solution may be significantly modified by a sufficiently intense beam of off-resonant light. A molecular analysis based on quantum electrodynamics (QED) fully accounts for this phenomenon of laser-modified absorption. A time-dependent perturbation-theory treatment describes the process in terms of stimulated forward Rayleigh-scattering of the auxiliary beam occurring simultaneously with the absorption interaction(s). Our formulation accommodates media modifications to the basic character of light-matter interactions, taking into account the refractive and dispersive properties of a solution-phase environment. This introduces the bulk refractive index of the solvent directly into the QED framework. The measurable electronic response of molecules freely rotating in solution is defined by an average of all orientations. We explicitly derive fixed-orientation and rotationally averaged calculations for the Fermi-rule rate of laser-modified one- and two-photon absorption. For a given beam polarization geometry, the solution-phase molecular response is expressible as a set of natural invariant scalars. These results reveal details of the dependence on the beam polarisations and on the rotationally averaged molecular response: we illustrate the breadth of variation available via geometric manipulation of beam polarization, and raise new possibilities for quantum weak measurements of laser states.

  16. Projection imaging of photon beams by the Čerenkov effect

    PubMed Central

    Glaser, Adam K.; Davis, Scott C.; McClatchy, David M.; Zhang, Rongxiao; Pogue, Brian W.; Gladstone, David J.

    2013-01-01

    Purpose: A novel technique for beam profiling of megavoltage photon beams was investigated for the first time by capturing images of the induced Čerenkov emission in water, as a potential surrogate for the imparted dose in irradiated media. Methods: A high-sensitivity, intensified CCD camera (ICCD) was configured to acquire 2D projection images of Čerenkov emission from a 4 × 4 cm2 6 MV linear accelerator (LINAC) x-ray photon beam operating at a dose rate of 400 MU/min incident on a water tank with transparent walls. The ICCD acquisition was gated to the LINAC sync pulse to reduce background light artifacts, and the measurement quality was investigated by evaluating the signal to noise ratio and measurement repeatability as a function of delivered dose. Monte Carlo simulations were used to derive a calibration factor for differences between the optical images and deposited dose arising from the anisotropic angular dependence of Čerenkov emission. Finally, Čerenkov-based beam profiles were compared to a percent depth dose (PDD) and lateral dose profile at a depth of dmax from a reference dose distribution generated from the clinical Varian ECLIPSE treatment planning system (TPS). Results: The signal to noise ratio was found to be 20 at a delivered dose of 66.6 cGy, and proportional to the square root of the delivered dose as expected from Poisson photon counting statistics. A 2.1% mean standard deviation and 5.6% maximum variation in successive measurements were observed, and the Monte Carlo derived calibration factor resulted in Čerenkov emission images which were directly correlated to deposited dose, with some spatial issues. The dose difference between the TPS and PDD predicted by Čerenkov measurements was within 20% in the buildup region with a distance to agreement (DTA) of 1.5–2 mm and ±3% at depths beyond dmax. In the lateral profile, the dose difference at the beam penumbra was within ±13% with a DTA of 0–2 mm, ±5% in the central beam region

  17. Magnetic fields with photon beams: dose calculation using electron multiple-scattering theory.

    PubMed

    Jette, D

    2000-08-01

    Strong transverse magnetic fields can produce large dose enhancements and reductions in localized regions of a patient under irradiation by a photon beam. We have developed a new equation of motion for the transport of charged particles in an arbitrary magnetic field, incorporating both energy loss and multiple scattering. Key to modeling the latter process is a new concept, that of "typical scattered particles." The formulas which we have arrived at are particularly applicable to the transport of, and deposition of energy by, Compton electrons and pair-production electrons and positrons generated within a medium by a photon beam, and we have shown qualitatively how large dose enhancements and reductions can occur. A companion article examines this dose modification effect through systematic Monte Carlo simulations.

  18. Determination of Endpoint Energy and Bremsstrahlung Spectra for High-Energy Radiation-Therapy Beams

    NASA Astrophysics Data System (ADS)

    Landry, Danny Joe

    Few attempts have been made to experimentally determine thick-target bremsstrahlung spectra of megavoltage therapy beams. For spectral studies using the Compton scattering technique, sodium iodine (NaI) detectors with relatively poor energy resolution have been used. Other experimental techniques for determining spectra are generally not suited for a clinical environment with the inherent time and space constraints. To gather more spectral information than previously obtained in the region near the endpoint energy, the use of a high-resolution intrinsic-germanium (Ge) detector was proposed. A response function matrix was determined from experimentally obtained pulse height distributions on the multichannel analyzer. The distributions were for nine various monoenergetic sources between 280 adn 1525 keV. The response function was used to convert the measured pulse height distributions to photon flux spectra using an iterative approximation technique with a computer. Photon flux spectra from the Sagittaire Linear Accelerator were obtained at average-electron endpoint energies of 15, 20, and 25 MeV. Two spectra were measured at the 25 MeV setting; one spectrum was measured along the central axis and one spectrum at 4(DEGREES) off axis. Photon spectra were also obtained for a Van de Graaff generator at the nominal endpoint energies of 2.2, 2.35, and 2.5 MeV. The results for both the linac and the Van de Graaff generator were compared with theoretical spectra and previously measured spectra where available. Also, photon spectra from a Theratron-80 (('60)Co) unit were determined for three field sizes and for a 10 x 10 cm. field with a lucite tray or a 45(DEGREES) wedge in the beam. The resulting spectra were compared to previously measured ('60)Co spectra.

  19. Linearly polarised photon beams at ELSA and measurement of the beam asymmetry in π0_{} photoproduction off the proton

    NASA Astrophysics Data System (ADS)

    Elsner, D.; Bantes, B.; Bartholomy, O.; Bayadilov, D. E.; Beck, R.; Beloglazov, Y. A.; Castelijns, R.; Crede, V.; Ehmanns, A.; Essig, K.; Ewald, R.; Fabry, I.; Frommberger, F.; Fornet-Ponse, K.; Fuchs, M.; Funke, C.; Gridnev, A. B.; Gutz, E.; Hillert, W.; Höffgen, S.; Hoffmeister, P.; Horn, I.; Jaegle, I.; Junkersfeld, J.; Kalinowsky, H.; Klein, Frank; Klein, Friedrich; Klempt, E.; Konrad, M.; Kotulla, M.; Krusche, B.; Löhner, H.; Lopatin, I. V.; Lotz, J.; Lugert, S.; Menze, D.; Mertens, T.; Messchendorp, J. G.; Metag, V.; Morales, C.; Nanova, M.; Novinski, D. V.; Novotny, R.; Ostrick, M.; Pant, L. M.; van Pee, H.; Pfeiffer, M.; Sarantsev, A. V.; Schmidt, C.; Schmieden, H.; Schoch, B.; Shende, S.; Süle, A.; Sumachev, V. V.; Szczepanek, T.; Thoma, U.; Trnka, D.; Walther, D.; Weinheimer, C.; Wendel, C.

    2009-03-01

    At the electron accelerator ELSA a linearly polarised tagged photon beam is produced by coherent bremsstrahlung off a diamond crystal. Orientation and energy range of the linear polarisation can be deliberately chosen by accurate positioning of the crystal with a goniometer. The degree of polarisation is determined by the form of the scattered electron spectrum. Good agreement between experiment and expectations on the basis of the experimental conditions is obtained. Polarisation degrees of ensuremath P_{γ}=40 % are typically achieved at half of the primary electron energy. The determination of ensuremath P_{γ} is confirmed by measuring the beam asymmetry, Σ , in π0_{} photoproduction and by a comparison of the results to independent measurements using laser backscattering.

  20. Tight control of light beams in photonic crystals with spatially-variant lattice orientation.

    PubMed

    Digaum, Jennefir L; Pazos, Javier J; Chiles, Jeffrey; D'Archangel, Jeffrey; Padilla, Gabriel; Tatulian, Adrian; Rumpf, Raymond C; Fathpour, Sasan; Boreman, Glenn D; Kuebler, Stephen M

    2014-10-20

    Spatially-variant photonic crystals (SVPCs), in which the orientation of the unit cell changes as a function of position, are shown to be capable of abruptly controlling light beams using just low index materials and can be made to have high polarization selectivity. Multi-photon direct laser writing in the photo-polymer SU-8 was used to fabricate three-dimensional SVPCs that direct the flow of light around a 90 degree bend. The lattice spacing and fill factor were maintained nearly constant throughout the structure. The SVPCs were characterized at a wavelength of 2.94 μm by scanning the faces with optical fibers and the results were compared to electromagnetic simulations. The lattices were shown to direct infrared light of one polarization through sharp bends while the other polarization propagated straight through the SVPC. This work introduces a new scheme for controlling light that should be useful for integrated photonics.

  1. Using photon funnels based on metamaterial cloaks to compress electromagnetic wave beams.

    PubMed

    Ma, Hua; Qu, Shaobo; Xu, Zhuo; Wang, Jiafu

    2008-08-10

    Based on the metamaterial cloaking technique, we propose the use of a new photon funnel to compress a plane electromagnetic (EM) wave. The theoretical analysis and numerical simulations indicate that the compression ratio can be designed optionally and the compressed wave beam remains the original wave shape without any distortions. Here we apply the method to EM waves but it can be applied to acoustic waves and other fields as well.

  2. Dosimetric study of thermoluminescent detectors in clinical photon beams using liquid water and PMMA phantoms.

    PubMed

    Matsushima, Luciana C; Veneziani, Glauco R; Sakuraba, Roberto K; da Cruz, José C; Campos, Letícia L

    2012-07-01

    The purpose of this study was the dosimetric evaluation of thermoluminescent detectors of calcium sulphate doped with dysprosium (CaSO4:Dy) produced by IPEN compared to the TL response of lithium fluoride doped with magnesium and titanium (LiF:Mg,Ti) dosimeters and microdosimeters produced by Harshaw Chemical Company to clinical photon beams dosimetry (6 and 15 MV) using liquid water and PMMA phantoms.

  3. Flattening Filter-Free Beams in Intensity-Modulated Radiotherapy and Volumetric Modulated Arc Therapy for Sinonasal Cancer

    PubMed Central

    Huang, Bao-Tian

    2016-01-01

    Purpose To evaluate the dosimetric impacts of flattening filter-free (FFF) beams in intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) for sinonasal cancer. Methods For fourteen cases, IMRT and VMAT planning was performed using 6-MV photon beams with both conventional flattened and FFF modes. The four types of plans were compared in terms of target dose homogeneity and conformity, organ-at-risk (OAR) sparing, number of monitor units (MUs) per fraction, treatment time and pure beam-on time. Results FFF beams led to comparable target dose homogeneity, conformity, increased number of MUs and lower doses to the spinal cord, brainstem and normal tissue, compared with flattened beams in both IMRT and VMAT. FFF beams in IMRT resulted in improvements by up to 5.4% for sparing of the contralateral optic structures, with shortened treatment time by 9.5%. However, FFF beams provided comparable overall OAR sparing and treatment time in VMAT. With FFF mode, VMAT yielded inferior homogeneity and superior conformity compared with IMRT, with comparable overall OAR sparing and significantly shorter treatment time. Conclusions Using FFF beams in IMRT and VMAT is feasible for the treatment of sinonasal cancer. Our results suggest that the delivery mode of FFF beams may play an encouraging role with better sparing of contralateral optic OARs and treatment efficiency in IMRT, but yield comparable results in VMAT. PMID:26734731

  4. Dosimetric characterization of CyberKnife radiosurgical photon beams using polymer gels

    SciTech Connect

    Pantelis, E.; Antypas, C.; Petrokokkinos, L.; Karaiskos, P.; Papagiannis, P.; Kozicki, M.; Georgiou, E.; Sakelliou, L.; Seimenis, I.

    2008-06-15

    Dose distributions registered in water equivalent, polymer gel dosimeters were used to measure the output factors and off-axis profiles of the radiosurgical photon beams employed for CyberKnife radiosurgery. Corresponding measurements were also performed using a shielded silicon diode commonly employed for CyberKnife commissioning, the PinPoint ion chamber, and Gafchromic EBT films, for reasons of comparison. Polymer gel results of this work for the output factors of the 5, 7.5, and 10 mm diameter beams are (0.702{+-}0.029), (0.872{+-}0.039), and (0.929{+-}0.041), respectively. Comparison of polymer gel and diode measurements shows that the latter overestimate output factors of the two small beams (5% for the 5 mm beam and 3% for the 7.5 mm beams). This is attributed to the nonwater equivalence of the high atomic number silicon material of the diode detector. On the other hand, the PinPoint chamber is found to underestimate output factors up to 10% for the 5 mm beam due to volume averaging effects. Polymer gel and EBT film output factor results are found in close agreement for all beam sizes, emphasizing the importance of water equivalence and fine detector sensitive volume for small field dosimetry. Relative off-axis profile results are in good agreement for all dosimeters used in this work, with noticeable differences observed only in the PinPoint estimate of the 80%-20% penumbra width, which is relatively overestimated.

  5. Vector meson and associated strangeness production using a linearly polarized photon beam at Jefferson Lab

    SciTech Connect

    Philip L. Cole

    2004-09-01

    The set of experiments forming the g8a run took place in the summer of 2001 in Hall B of Jefferson Lab. The g8a run was the commissioning experiment for the linearly-polarized photon beam at CLAS. The aim of these experiments is to improve the understanding of the underlying symmetry of the quark degrees of freedom in the nucleon, the nature of the parity exchange between the incident photon and the target nucleon, and the mechanism of associated strangeness production in electromagnetic reactions. A beam of tagged and collimated linearly polarized photons (energy range 1.8-2.2 GeV) in conjunction with the large solid angle coverage of CLAS make possible the extraction of the differential cross-sections and polarization observables for the photoproduction of vector mesons and kaons. The reaction channels are under investigation to search for possibly missing nucleon resonances. An overview of the experiment and preliminary results on the measurement of the photon asymmetries of the aforementioned reactions will be presented in this paper.

  6. Nonlinear Interaction of the Beat-Photon Beams with the Brain Neurocenters: Laser Neurophysics

    NASA Astrophysics Data System (ADS)

    Stefan, V. Alexander

    2010-03-01

    I propose a novel mechanism for laser-brain interaction: Nonlinear interaction of ultrashort pulses of beat-photon, (φ1-- φ2), or double-photon, (φ1+φ2), footnotetextMaria Goeppert-Mayer, "Uber Elementarakte mit zwei Quantenspr"ungen, Ann Phys 9, 273, 95. (1931). beams with the corrupted brain neurocenters, causing a particular neurological disease. The open-scull cerebral tissue can be irradiated with the beat-photon pulses in the range of several 100s fs, with the laser irradiances in the range of a few mW/cm^2, repetition rate of a few 100s Hz, and in the frequency range of 700-1300nm generated in the beat-wave driven free electron laser.footnotetextV. Alexander Stefan, The Interaction of Photon Beams with the DNA Molecules: Genomic Medical Physics. American Physical Society, 2009 APS March Meeting, March 16-20, 2009, abstract #K1.276; V. Stefan, B. I. Cohen, and C. Joshi, Nonlinear Mixing of Electromagnetic Waves in Plasmas Science 27 January 1989:Vol. 243. no. 4890, pp. 494 -- 500 (January 1989). This method may prove to be an effective mechanism in the treatment of neurological diseases: Parkinson's, Lou Gehrig's, and others.

  7. Three-photon resonant atomic excitation in spatially incoherent laser beams

    SciTech Connect

    Peet, Victor; Shchemeljov, Sergei

    2003-10-01

    Two-color excitation by spatially coherent and incoherent laser beams has been used to study three-photon-resonant excitation and subsequent ionization of xenon in conditions, when internally generated sum-frequency field plays an important role in excitation of atomic resonances through interfering one-photon excitation pathway. We show that the incoherence in one of the pumping fields reduces the efficiency of generated sum-frequency field, and thus suppresses the interference between the three- and the one-photon excitation channels. The degree of suppression is controlled by varying the crossing angle between coherent and incoherent laser beams. We show that ionization profiles can be analyzed on the basis of the well-studied interference of one- and three-photon transition amplitudes, but with pumping field decomposed into multiple small-scale uncorrelated domains where coherent process of four-wave mixing occurs. The gain length for a coherent process in these domains depends on the coherence degree and excitation geometry. It gives a possibility of controlling the contribution of coherent processes to the excitation of multiphoton resonances.

  8. The influence of bowtie filtration on x-ray photons distribution in cone beam CT

    NASA Astrophysics Data System (ADS)

    Jiang, Shanghai; Feng, Peng; Wei, Biao; He, Peng; Deng, Luzhen; Zhang, Wei

    2015-10-01

    Bowtie filters are used to modulate an incoming x-ray beam as a function of the angle of the x-ray to balance the photon flux on a detector array. Because of their key roles in radiation dose reduction and multi-energy imaging, bowtie filters have attracted a major attention in modern X-ray computed tomography (CT). However, few researches are concerned on the effects of the structure and materials for the bowtie filter in the Cone Beam CT (CBCT). In this study, the influence of bowtie filters' structure and materials on X-ray photons distribution are analyzed using Monte Carlo (MC) simulations by MCNP5 code. In the current model, the phantom was radiated by virtual X-ray source (its' energy spectrum calculated by SpekCalc program) filtered using bowtie, then all photons were collected through array photoncounting detectors. In the process above, two bowtie filters' parameters which include center thickness (B), edge thickness (controlled by A), changed respectively. Two kinds of situation are simulated: 1) A=0.036, B=1, 2, 3, 4, 5, 6mm and the material is aluminum; 2) A=0.016, 0.036, 0.056, 0.076, 0.096, B=2mm and the material is aluminum. All the X-ray photons' distribution are measured through MCNP. The results show that reduction in center thickness and edge thickness can reduce the number of background photons in CBCT. Our preliminary research shows that structure parameters of bowtie filter can influence X-ray photons, furthermore, radiation dose distribution, which provide some evidences in design of bowtie filter for reducing radiation dose in CBCT.

  9. Proton Beam Therapy for Aged Patients With Hepatocellular Carcinoma

    SciTech Connect

    Hata, Masaharu Tokuuye, Koichi; Sugahara, Shinji; Tohno, Eriko; Nakayama, Hidetsugu; Fukumitsu, Nobuyoshi; Mizumoto, Masashi; Abei, Masato; Shoda, Junichi; Minami, Manabu; Akine, Yasuyuki

    2007-11-01

    Purpose: To investigate the safety and efficacy of proton beam therapy for aged patients with hepatocellular carcinoma (HCC). Methods and Materials: Twenty-one patients aged {>=}80 years with HCC underwent proton beam therapy. At the time of irradiation, patient age ranged from 80 to 85 years (median, 81 years). Hepatic tumors were solitary in 17 patients and multiple in 4. Tumor size ranged from 10 to 135 mm (median, 40 mm) in maximum diameter. Ten, 5, and 6 patients received proton beam irradiation with total doses of 60 Gy in 10 fractions, 66 Gy in 22 fractions, and 70 Gy in 35 fractions, respectively, according to tumor location. Results: All irradiated tumors were controlled during the follow-up period of 6-49 months (median, 16 months). Five patients showed new hepatic tumors outside the irradiated volume, 2-13 months after treatment, and 1 of them also had lung metastasis. The local progression-free and disease-free rates were 100% and 72% at 3 years, respectively. Of 21 patients, 7 died 6-49 months after treatment; 2 patients each died of trauma and old age, and 1 patient each died of HCC, pneumonia, and arrhythmia. The 3-year overall, cause-specific, and disease-free survival rates were 62%, 88%, and 51%, respectively. No therapy-related toxicity of Grade {>=} 3 but thrombocytopenia in 2 patients was observed. Conclusions: Proton beam therapy seems to be tolerable, effective, and safe for aged patients with HCC. It may contribute to prolonged survival due to tumor control.

  10. Production and dosimetry of simultaneous therapeutic photons and electrons beam by linear accelerator: A Monte Carlo study

    SciTech Connect

    Khledi, Navid; Sardari, Dariush; Arbabi, Azim; Ameri, Ahmad; Mohammadi, Mohammad

    2015-02-24

    Depending on the location and depth of tumor, the electron or photon beams might be used for treatment. Electron beam have some advantages over photon beam for treatment of shallow tumors to spare the normal tissues beyond of the tumor. In the other hand, the photon beam are used for deep targets treatment. Both of these beams have some limitations, for example the dependency of penumbra with depth, and the lack of lateral equilibrium for small electron beam fields. In first, we simulated the conventional head configuration of Varian 2300 for 16 MeV electron, and the results approved by benchmarking the Percent Depth Dose (PDD) and profile of the simulation and measurement. In the next step, a perforated Lead (Pb) sheet with 1mm thickness placed at the top of the applicator holder tray. This layer producing bremsstrahlung x-ray and a part of the electrons passing through the holes, in result, we have a simultaneous mixed electron and photon beam. For making the irradiation field uniform, a layer of steel placed after the Pb layer. The simulation was performed for 10×10, and 4×4 cm2 field size. This study was showed the advantages of mixing the electron and photon beam by reduction of pure electron's penumbra dependency with the depth, especially for small fields, also decreasing of dramatic changes of PDD curve with irradiation field size.

  11. Correlation study of a beam-position monitor and a photon-beam-position monitor in the PLS-II

    NASA Astrophysics Data System (ADS)

    Kim, Changbum; Shin, Seunghwan; Hwang, Ilmoon; Lee, Byung-Joon; Joo, Young-Do; Ha, Taekyun; Yoon, Jong Chel; Kim, Ghyung Hwa; Kim, Mungyung; Lee, Eun Hee; Kim, Ilyou; Huang, Jung-Yun

    2015-01-01

    The beam stability is one of the most important issues for the user service of the synchrotron radiation facility. After the upgrade of the Pohang Light Source (PLS-II), the electron-beam orbit is maintained within a root-mean-squred (rms) 1- μm range by using an orbit feedback system. However, that does not guarantee the radiation stability at the end of the beamline because unknown factors, such as focusing mirrors and double-crystal monocrometers, are present in the beamline. As a first step to solve this problem, photon-beam-position monitors (PBPMs) are installed in the front ends of the beamline to monitor the radiation stability. If the radiation is stable at the starting point of the beamline, we can move to the other components downstream that make the radiation unstable. In this paper, a correlation study will be presented between the beam-position monitor (BPM) and the PBPM. In addition, the effect of the orbit feedback system on the correlation will be described.

  12. Ecliptic method for the determination of backscatter into the beam monitor chambers in photon beams of medical accelerators.

    PubMed

    Sanz, Darío Esteban; Alvarez, Guillermo Daniel; Nelli, Flavio Enrico

    2007-03-21

    A new method to measure the effect of the backscatter into the beam monitor chambers in linear accelerators is introduced from first principles. The technique, applicable to high-energy photon beams, is similar to the well-known telescopic method although here the heavy blocks are replaced by a very small, centred block on the shadow tray, thus the name 'ecliptic method'. This effect, caused mainly by backscattering from the secondary collimators, is known to be an output factor constituent and must be accounted for when detailed calculations involving the machine's head are required. Since its magnitude is generally small, experimental errors might obscure the behaviour of the phenomenon. Consequently, the procedure introduced goes along with an uncertainty assessment. Our theory was confirmed via measurements in cobalt-60 beams, where the studied effect does not contribute to the output factor. Measurements were also performed on our Saturne 41 linear accelerator and the results were qualitatively similar to those described elsewhere. The collimation systems were studied separately by varying one jaw setting while keeping the other at its maximum value. In the light of these results, we deduced an algorithm that can correlate the former data with the effect of backscattering to the beam monitor chambers for any rectangular field within 0.5%, which is of the order of the experimental uncertainty (0.6%). As we show, the experimental procedure is safe, simple, not invasive for the linac and requires only basic dosimetry equipment.

  13. Highly Effective Light Beam Diffraction on Holographic PDLC Photonic Structure, Controllable by the Spatially Inhomogeneous Electric Field

    NASA Astrophysics Data System (ADS)

    Semkin, A. O.; Sharangovich, S. N.

    In this work the highly effiective light beam diffraction on holographic photonic structure formed in polymer-dispersed liquid crystal (PDLCs) is theoretically described. The ability to manage its diffraction characteristics by the spatially inhomogeneous electric field is also shown.

  14. Relative biological damage in and out of field of 6, 10 and 18 MV clinical photon beams

    NASA Astrophysics Data System (ADS)

    Ezzati, A. O.

    2016-08-01

    The lower energy of scattered radiation in and out of a megavoltage (MV) photon beam suggests that relative biological damage (RBD) may change from in- to out-of-field regions for unit absorbed dose. Because of high linear energy transfer (LET) and potential of causing severe damage to the DNA, low-energy (10 eV-1 keV) slowing down electrons should be included in radiation biological damage calculations. In this study RBD was calculated in and out of field of 6, 10 and 18 MV clinical photon beams including low-energy slowing down electrons in the track length estimated method. Electron spectra at energies higher than 2 keV were collected in a water phantom at different depths and off-axis points by using the MCNP code. A new extrapolation method was used to estimate the electron spectra at energies lower than 2 keV. The obtained spectra at energies lower than 2 keV merged with spectra at energies higher than 2 keV by using continuity of the spectra. These spectra were used as an input to a validated microdosimetric Monte Carlo (MC) code, MC damage simulation (MCDS), to calculate the RBD of induced DSB in DNA at points in and out of the primary radiation field under fully aerobic (100% O2 and anoxic (0% O2 conditions. There was an observable difference in the energy spectra for electrons for points in the primary radiation field and those points out of field. RBD had maximum variation, 11% in 6 MV photons at field size of 20×20 cm2. This variation was less than 11% for 10 and 18 MV photons and field sizes smaller than 20×20 cm2. Our simulations also showed that under the anoxic condition, RBD increases up to 6% for 6 and 10 MV photons and the 20×20 cm2 field size. This work supports the hypothesis that in megavoltage treatments out-of-field radiation quality can vary enough to have an impact on RBD per unit dose and that this may play a role as the radiation therapy community explores biological optimization as a tool to assist treatment planning.

  15. A GSH-activatable ruthenium(ii)-azo photosensitizer for two-photon photodynamic therapy.

    PubMed

    Zeng, Leli; Kuang, Shi; Li, Guanying; Jin, Chengzhi; Ji, Liangnian; Chao, Hui

    2017-02-07

    A glutathione (GSH)-activatable ruthenium(ii)-azo photosensitizer was prepared. The complex had low toxicity towards cells under dark conditions. It exhibited excellent phototoxicity under two-photon excitation (810 nm) and thus was developed as a two-photon photodynamic anticancer agent for cancer therapy.

  16. A Novel Approach to Postmastectomy Radiation Therapy Using Scanned Proton Beams

    SciTech Connect

    Depauw, Nicolas; Batin, Estelle; Daartz, Julianne; Rosenfeld, Anatoly; Adams, Judith; Kooy, Hanne; MacDonald, Shannon; Lu, Hsiao-Ming

    2015-02-01

    Purpose: Postmastectomy radiation therapy (PMRT), currently offered at Massachusetts General Hospital, uses proton pencil beam scanning (PBS) with intensity modulation, achieving complete target coverage of the chest wall and all nodal regions and reduced dose to the cardiac structures. This work presents the current methodology for such treatment and the ongoing effort for its improvements. Methods and Materials: A single PBS field is optimized to ensure appropriate target coverage and heart/lung sparing, using an in–house-developed proton planning system with the capability of multicriteria optimization. The dose to the chest wall skin is controlled as a separate objective in the optimization. Surface imaging is used for setup because it is a suitable surrogate for superficial target volumes. In order to minimize the effect of beam range uncertainties, the relative proton stopping power ratio of the material in breast implants was determined through separate measurements. Phantom measurements were also made to validate the accuracy of skin dose calculation in the treatment planning system. Additionally, the treatment planning robustness was evaluated relative to setup perturbations and patient breathing motion. Results: PBS PMRT planning resulted in appropriate target coverage and organ sparing, comparable to treatments by passive scattering (PS) beams but much improved in nodal coverage and cardiac sparing compared to conventional treatments by photon/electron beams. The overall treatment time was much shorter than PS and also shorter than conventional photon/electron treatment. The accuracy of the skin dose calculation by the planning system was within ±2%. The treatment was shown to be adequately robust relative to both setup uncertainties and patient breathing motion, resulting in clinically satisfying dose distributions. Conclusions: More than 25 PMRT patients have been successfully treated at Massachusetts General Hospital by using single-PBS fields

  17. Effect of Scanning Beam for Superficial Dose in Proton Therapy.

    PubMed

    Moskvin, Vadim P; Estabrook, Neil C; Cheng, Chee-Wai; Das, Indra J; Johnstone, Peter A S

    2015-10-01

    Proton beam delivery technology is under development to minimize the scanning spot size for uniform dose to target, but it is also known that the superficial dose could be as high as the dose at Bragg peak for narrow and small proton beams. The objective of this study is to explore the characteristics of dose distribution at shallow depths using Monte Carlo simulation with the FLUKA code for uniform scanning (US) and discrete spot scanning (DSS) proton beams. The results show that the superficial dose for DSS is relatively high compared to US. Additionally, DSS delivers a highly heterogeneous dose to the irradiated surface for comparable doses at Bragg peak. Our simulation shows that the superficial dose can become as high as the Bragg peak when the diameter of the proton beam is reduced. This may compromise the advantage of proton beam therapy for sparing normal tissue, making skin dose a limiting factor for the clinical use of DSS. Finally, the clinical advantage of DSS may not be essential for treating uniform dose across a large target, as in craniospinal irradiation (CSI).

  18. The bremsstrahlung tagged photon beam in Hall B at the Jefferson Laboratory

    SciTech Connect

    Daniel I. Sober; Hall Crannell; Alberto Longhi; Scott Matthews; James T. O'Brien; Barry L. Berman; William Briscoe; Philip L. Cole; James Connelly; W.R. Dodge; Luc Y. Murphy; S.A. Phillips; Michael Dugger; David Lawrence; Barry G. Ritchie; Elton Smith; J.M. Lambert; Eric P.M. Anciant; Gerad Audit; Thierry Auger; Claude Marchand; Michael Klusman; James Napolitano; M.A. Khandaker; Carlos Salgado; Adam Sarty

    2000-02-01

    We describe the design and commissioning of the photon tagging beamline installed in experimental Hall B at the Thomas Jefferson National Accelerator Facility (Jlab). This system can tag photon energies over a range from 20% to 95% of the incident electron energy, and is capable of operation with beam energies up to 6.1 GeV. A single dipole magnet is combined with a hodoscope containing two planar arrays of plastic scintillators to detect energy-degraded electrons from a thin bremsstrahlung radiator. The first layer of 384 partially overlapping small scintillators provides photon energy resolution, while the second layer of 61 larger scintillators provides the timing resolution necessary to form a coincidence with the corresponding nuclear interaction triggered by the tagged photon. The definitions of overlap channels in the first counter plane and of geometric correlation between the two planes are determined using digitized time information from the individual counters. Auxiliary beamline devices are briefly described, and performance results to date under real operating conditions are presented. The entire photon-tagging system has met or exceeded its design goals.

  19. Monte Carlo simulation on pre-clinical irradiation: A heterogeneous phantom study on monoenergetic kilovoltage photon beams

    NASA Astrophysics Data System (ADS)

    Chow, James C. L.

    2012-10-01

    This study investigated radiation dose variations in pre-clinical irradiation due to the photon beam energy and presence of tissue heterogeneity. Based on the same mouse computed tomography image dataset, three phantoms namely, heterogeneous, homogeneous and bone homogeneous were used. These phantoms were generated by overriding the relative electron density of no voxel (heterogeneous), all voxel (homogeneous) and the bone voxel (bone homogeneous) to one. 360° photon arcs with beam energies of 50 - 1250 keV were used in mouse irradiations. Doses in the above phantoms were calculated using the EGSnrc-based DOSXYZnrc code through the DOSCTP. Monte Carlo simulations were carried out in parallel using multiple nodes in a high-performance computing cluster. It was found that the dose conformity increased with the increase of the photon beam energy from the keV to MeV range. For the heterogeneous mouse phantom, increasing the photon beam energy from 50 keV to 1250 keV increased seven times the dose deposited at the isocenter. For the bone dose enhancement, the mean dose was 2.7 times higher when the bone heterogeneity was not neglected using the 50 keV photon beams in the mouse irradiation. Bone dose enhancement affecting the mean dose was found in the photon beams with energy range of 50 - 200 keV and the dose enhancement decreased with an increase of the beam energy. Moreover, the MeV photon beam had a higher dose at the isocenter, and a better dose conformity compared to the keV beam.

  20. Characteristics of Movement-Induced Dose Reduction in Target Volume: A Comparison Between Photon and Proton Beam Treatment

    SciTech Connect

    Yoon, Myonggeun; Shin, Dongho; Kwak, Jungwon; Park, Soah; Lim, Young Kyung; Kim, Dongwook; Park, Sung Yong Lee, Se Byeong; Shin, Kyung Hwan; Kim, Tae Hyun; Cho, Kwan Ho

    2009-10-01

    We compared the main characteristics of movement-induced dose reduction during photon and proton beam treatment, based on an analysis of dose-volume histograms. To simulate target movement, a target contour was delineated in a scanned phantom and displaced by 3 to 20 mm. Although the dose reductions to the target in the 2 treatment systems were similar for transverse (perpendicular to beam direction) target motion, they were completely different for longitudinal (parallel to beam direction) target motion. While both modalities showed a relationship between the degree of target shift and the reduction in dose coverage, dose reduction showed a strong directional dependence in proton beam treatment. Clinical simulation of target movement for a prostate cancer patient showed that, although coverage and conformity indices for a 6-mm lateral movement of the prostate were reduced by 9% and 16%, respectively, for proton beam treatment, they were reduced by only 1% and 7%, respectively, for photon treatment. This difference was greater for a 15-mm target movement in the lateral direction, which lowered the coverage and conformity indices by 34% and 54%, respectively, for proton beam treatment, but changed little during photon treatment. In addition, we found that the equivalent uniform dose (EUD) and homogeneity index show similar characteristics during target movement. These results suggest that movement-induced dose reduction differs significantly between photon and proton beam treatment. Attention should be paid to the target margin in proton beam treatment due to the distinct characteristics of heavy ion beams.

  1. Characterization of a Fricke dosimeter at high energy photon and electron beams used in radiotherapy.

    PubMed

    Moussous, O; Khoudri, S; Benguerba, M

    2011-12-01

    The dosimetric features of the Fricke dosimeter in clinical linear accelerator beams are considered. Experimental data were obtained using various nominal energies 6 and 18 MV, 12 and 15 MeV, including the (60)Co γ-ray beam. The calibration of the dosimeters was performed using the ionization chamber as a reference dosimeter. Some general characteristics of Fricke dosimeter such as energy dependence, optical density (OD)-dose relationship, reproducibility, accuracy, dose rate dependence were analyzed. The Fricke solution shows linearity in OD-dose relationship, energy independence and a good reproducibility over the energy range investigated. The Fricke dosimeter was found to be suitable for carrying out absorbed dose to water measurements in the calibration of high energy electron and photon beams.

  2. Photonuclear dose calculations for high-energy photon beams from Siemens and Varian linacs.

    PubMed

    Chibani, Omar; Ma, Chang-Ming Charlie

    2003-08-01

    The dose from photon-induced nuclear particles (neutrons, protons, and alpha particles) generated by high-energy photon beams from medical linacs is investigated. Monte Carlo calculations using the MCNPX code are performed for three different photon beams from two different machines: Siemens 18 MV, Varian 15 MV, and Varian 18 MV. The linac head components are simulated in detail. The dose distributions from photons, neutrons, protons, and alpha particles are calculated in a tissue-equivalent phantom. Neutrons are generated in both the linac head and the phantom. This study includes (a) field size effects, (b) off-axis dose profiles, (c) neutron contribution from the linac head, (d) dose contribution from capture gamma rays, (e) phantom heterogeneity effects, and (f) effects of primary electron energy shift. Results are presented in terms of absolute dose distributions and also in terms of DER (dose equivalent ratio). The DER is the maximum dose from the particle (neutron, proton, or alpha) divided by the maximum photon dose, multiplied by the particle quality factor and the modulation scaling factor. The total DER including neutrons, protons, and alphas is about 0.66 cSv/Gy for the Siemens 18 MV beam (10 cm x 10 cm). The neutron DER decreases with decreasing field size while the proton (or alpha) DER does not vary significantly except for the 1 cm x 1 cm field. Both Varian beams (15 and 18 MV) produce more neutrons, protons, and alphas particles than the Siemens 18 MV beam. This is mainly due to their higher primary electron energies: 15 and 18.3 MeV, respectively, vs 14 MeV for the Siemens 18 MV beam. For all beams, neutrons contribute more than 75% of the total DER, except for the 1 cm x 1 cm field (approximately 50%). The total DER is 1.52 and 2.86 cSv/Gy for the 15 and 18 MV Varian beams (10 cm x 10 cm), respectively. Media with relatively high-Z elements like bone may increase the dose from heavy charged particles by a factor 4. The total DER is sensitive to

  3. Tuning beam power-splitting characteristics through modulating a photonic crystal slab’s output surface

    NASA Astrophysics Data System (ADS)

    Feng, Shuai; Xiao, Ting-Hui; Gan, Lin; Wang, Yi-Quan

    2017-01-01

    Light-beam-splitting characteristics are theoretically and experimentally studied in 2D square-lattice photonic crystals (PhCs) with delicately designed and modulated output surfaces. Compared with the traditional branch-waveguide and self-collimation-type PhC splitters, our proposed structure can not only split the input light beam into different numbers of branches but also realize the adjustment of their relative light intensities in each branch. Moreover, the influence of a light beam’s incident angle on both the output branch beams’ relative intensity and propagation direction is investigated. This proposed light beam splitter is able to work within a broad frequency range, and the propagation directions of the output split beams can be modified with the incident beam’s frequency. In addition, when the PhC device becomes thicker, a kind of light-beam-focusing phenomenon is observed. Advantageously, our light-beam-splitting device has no restriction as to the incident light beam’s location and width, so it is much more convenient and practical for achieving optical connection with other functional devices in complicated, large-scale, all-optical integrated circuits.

  4. Commissioning measurements for photon beam data on three TrueBeam linear accelerators, and comparison with Trilogy and Clinac 2100 linear accelerators.

    PubMed

    Beyer, Gloria P

    2013-01-07

    This study presents the beam data measurement results from the commissioning of three TrueBeam linear accelerators. An additional evaluation of the measured beam data within the TrueBeam linear accelerators contrasted with two other linear accelerators from the same manufacturer (i.e., Clinac and Trilogy) was performed to identify and evaluate any differences in the beam characteristics between the machines and to evaluate the possibility of beam matching for standard photon energies. We performed a comparison of commissioned photon beam data for two standard photon energies (6 MV and 15 MV) and one flattening filter-free ("FFF") photon energy (10 FFF) between three different TrueBeam linear accelerators. An analysis of the beam data was then performed to evaluate the reproducibility of the results and the possibility of "beam matching" between the TrueBeam linear accelerators. Additionally, the data from the TrueBeam linear accelerator was compared with comparable data obtained from one Clinac and one Trilogy linear accelerator models produced by the same manufacturer to evaluate the possibility of "beam matching" between the TrueBeam linear accelerators and the previous models. The energies evaluated between the linear accelerator models are the 6 MV for low energy and the 15 MV for high energy. PDD and output factor data showed less than 1% variation and profile data showed variations within 1% or 2 mm between the three TrueBeam linear accelerators. PDD and profile data between the TrueBeam, the Clinac, and Trilogy linear accelerators were almost identical (less than 1% variation). Small variations were observed in the shape of the profile for 15 MV at shallow depths (< 5 cm) probably due to the differences in the flattening filter design. A difference in the penumbra shape was observed between the TrueBeam and the other linear accelerators; the TrueBeam data resulted in a slightly greater penumbra width. The diagonal scans demonstrated significant differences

  5. An experiment of X-ray photon-photon elastic scattering with a Laue-case beam collider

    NASA Astrophysics Data System (ADS)

    Yamaji, T.; Inada, T.; Yamazaki, T.; Namba, T.; Asai, S.; Kobayashi, T.; Tamasaku, K.; Tanaka, Y.; Inubushi, Y.; Sawada, K.; Yabashi, M.; Ishikawa, T.

    2016-12-01

    We report a search for photon-photon elastic scattering in vacuum in the X-ray region at an energy in the center of mass system of ωcms = 6.5keV for which the QED cross section is σQED = 2.5 ×10-47m2. An X-ray beam provided by the SACLA X-ray Free Electron Laser is split and the two beamlets are made to collide at right angle, with a total integrated luminosity of (1.24 ± 0.08) ×1028m-2. No signal X rays from the elastic scattering that satisfy the correlation between energy and scattering angle were detected. We obtain a 95% C.L. upper limit for the scattering cross section of 1.9 ×10-27m2 at ωcms = 6.5keV. The upper limit is the lowest upper limit obtained so far by keV experiments.

  6. SU-E-T-781: Using An Electronic Portal Imaging Device (EPID) for Correlating Linac Photon Beam Energies

    SciTech Connect

    Yaddanapudi, S; Cai, B; Sun, B; Noel, C; Goddu, S; Mutic, S

    2015-06-15

    Purpose: Electronic portal imaging devices (EPIDs) have proven to be useful for measuring several parameters of interest in linear accelerator (linac) quality assurance (QA). The purpose of this project was to evaluate the feasibility of using EPIDs for determining linac photon beam energies. Methods: Two non-clinical Varian TrueBeam linacs (Varian Medical Systems, Palo Alto, CA) with 6MV and 10MV photon beams were used to perform the measurements. The linacs were equipped with an amorphous silicon based EPIDs (aSi1000) that were used for the measurements. We compared the use of flatness versus percent depth dose (PDD) for predicting changes in linac photon beam energy. PDD was measured in 1D water tank (Sun Nuclear Corporation, Melbourne FL) and the profiles were measured using 2D ion-chamber array (IC-Profiler, Sun Nuclear) and the EPID. Energy changes were accomplished by varying the bending magnet current (BMC). The evaluated energies conformed with the AAPM TG142 tolerance of ±1% change in PDD. Results: BMC changes correlating with a ±1% change in PDD corresponded with a change in flatness of ∼1% to 2% from baseline values on the EPID. IC Profiler flatness values had the same correlation. We observed a similar trend for the 10MV beam energy changes. Our measurements indicated a strong correlation between changes in linac photon beam energy and changes in flatness. For all machines and energies, beam energy changes produced change in the uniformity (AAPM TG-142), varying from ∼1% to 2.5%. Conclusions: EPID image analysis of beam profiles can be used to determine linac photon beam energy changes. Flatness-based metrics or uniformity as defined by AAPM TG-142 were found to be more sensitive to linac photon beam energy changes than PDD. Research funding provided by Varian Medical Systems. Dr. Sasa Mutic receives compensation for providing patient safety training services from Varian Medical Systems, the sponsor of this study.

  7. Variation of sensitometric curves of radiographic films in high energy photon beams.

    PubMed

    Danciu, C; Proimos, B S; Rosenwald, J C; Mijnheer, B J

    2001-06-01

    Film dosimetry is an important tool for the verification of irradiation techniques. The shape of the sensitometric curve depends on the type of film as well as on the irradiation and processing conditions. Existing data concerning the influence of irradiation geometry on the sensitometric curve are conflicting. In particular the variation of optical density, OD, with field size and depth in a phantom shows large differences in magnitude between various authors. This variation, as well as the effect of beam energy and film plane orientation on OD, was therefore investigated for two types of film, Kodak X-Omat V and Agfa Structurix D2. Films were positioned in a solid phantom, either perpendicular or (almost) parallel to the beam axis, and irradiated to different dose levels using various photon beams (Co-60, 6 MV, 15 MV, 18 MV, 45 MV). It was found that the sensitometric curves of the Kodak film derived at different depths are almost identical for the four x-ray beams. For the Kodak film the differences in OD with depth are less than 2%, except for the Co-60 beam, where the difference is about 4% at 10 cm depth for a 15 cm x 15 cm field. The slope of the sensitometric curve of the Agfa film is somewhat more dependent on photon beam energy, depth and field size. The sensitometric curves of both types of film are almost independent of the film plane orientation, except for shallow depths. For Co-60 and for the same dose, the Kodak and Agfa films gave at dose maximum an OD lower by 4% and 6%, respectively, for the parallel compared to the perpendicular geometry. Good dosimetric results can be obtained if films from the same batch are irradiated with small to moderate field sizes (up to about 15 cm x 15 cm), at moderate depths (up to about 15 cm), using a single calibration curve, e.g., for a 10 cm x 10 cm field.

  8. Assessment of ionization chamber correction factors in photon beams using a time saving strategy with PENELOPE code.

    PubMed

    Reis, C Q M; Nicolucci, P

    2016-02-01

    The purpose of this study was to investigate Monte Carlo-based perturbation and beam quality correction factors for ionization chambers in photon beams using a saving time strategy with PENELOPE code. Simulations for calculating absorbed doses to water using full spectra of photon beams impinging the whole water phantom and those using a phase-space file previously stored around the point of interest were performed and compared. The widely used NE2571 ionization chamber was modeled with PENELOPE using data from the literature in order to calculate absorbed doses to the air cavity of the chamber. Absorbed doses to water at reference depth were also calculated for providing the perturbation and beam quality correction factors for that chamber in high energy photon beams. Results obtained in this study show that simulations with phase-space files appropriately stored can be up to ten times shorter than using a full spectrum of photon beams in the input-file. Values of kQ and its components for the NE2571 ionization chamber showed good agreement with published values in the literature and are provided with typical statistical uncertainties of 0.2%. Comparisons to kQ values published in current dosimetry protocols such as the AAPM TG-51 and IAEA TRS-398 showed maximum percentage differences of 0.1% and 0.6% respectively. The proposed strategy presented a significant efficiency gain and can be applied for a variety of ionization chambers and clinical photon beams.

  9. Particle selection and beam collimation system for laser-accelerated proton beam therapy.

    PubMed

    Luo, Wei; Fourkal, Eugene; Li, Jinsheng; Ma, Chang-Ming

    2005-03-01

    In a laser-accelerated proton therapy system, the initial protons have broad energy and angular distributions, which are not suitable for direct therapeutic applications. A compact particle selection and collimation device is needed to deliver small pencil beams of protons with desired energy spectra. In this work, we characterize a superconducting magnet system that produces a desired magnetic field configuration to spread the protons with different energies and emitting angles for particle selection. Four magnets are set side by side along the beam axis; each is made of NbTi wires which carry a current density of approximately 10(5) A/cm2 at 4.2 K, and produces a magnetic field of approximately 4.4 T in the corresponding region. Collimation is applied to both the entrance and the exit of the particle selection system to generate a desired proton pencil beam. In the middle of the magnet system, where the magnetic field is close to zero, a particle selection collimator allows only the protons with desired energies to pass through for therapy. Simulations of proton transport in the presence of the magnetic field show that the selected protons have successfully refocused on the beam axis after passing through the magnetic field with the optimal magnet system. The energy spread for any given characteristic proton energy has been obtained. It is shown that the energy spread is a function of the magnetic field strength and collimator size and reaches the full width at half maximum of 25 MeV for 230 MeV protons. Dose distributions have also been calculated with the GEANT3 Monte Carlo code to study the dosimetric properties of the laser-accelerated proton beams for radiation therapy applications.

  10. Multi-strip silicon sensors for beam array monitoring in micro-beam radiation therapy.

    PubMed

    Alagoz, E; Brauer-Krisch, E; Bravin, A; Cornelius, I; Fournier, P; Hansen, T E; Kok, A; Lerch, M; Monakhov, E; Morse, J; Pacifico, N; Petasecca, M; Povoli, M; Requard, H; Rozenfeld, A D; Salome, M; Sandaker, H; Stugu, B

    2016-12-01

    We present here the latest results from tests performed at the ESRF ID17 and ID21 beamlines for the characterization of novel beam monitors for Microbeam Radiation Therapy (MRT), which is currently being implemented at ID17. MRT aims at treating solid tumors by exploiting an array of evenly spaced microbeams, having an energy spectrum distributed between 27 and 600keV and peaking at 100keV. Given the high instantaneous dose delivered (up to 20kGy/s), the position and the intensity of the microbeams has to be precisely and instantly monitored. For this purpose, we developed dedicated silicon microstrip beam monitors. We have successfully characterized them, both with a microbeam array at ID17, and a submicron scanning beam at ID21. We present here the latest results obtained in recent tests along with an outlook on future developments.

  11. Performance of MACACO Compton telescope for ion-beam therapy monitoring: first test with proton beams.

    PubMed

    Solevi, Paola; Muñoz, Enrique; Solaz, Carles; Trovato, Marco; Dendooven, Peter; Gillam, John E; Lacasta, Carlos; Oliver, Josep F; Rafecas, Magdalena; Torres-Espallardo, Irene; Llosá, Gabriela

    2016-07-21

    In order to exploit the advantages of ion-beam therapy in a clinical setting, delivery verification techniques are necessary to detect deviations from the planned treatment. Efforts are currently oriented towards the development of devices for real-time range monitoring. Among the different detector concepts proposed, Compton cameras are employed to detect prompt gammas and represent a valid candidate for real-time range verification. We present the first on-beam test of MACACO, a Compton telescope (multi-layer Compton camera) based on lanthanum bromide crystals and silicon photo-multipliers. The Compton telescope was first characterized through measurements and Monte Carlo simulations. The detector linearity was measured employing (22)Na and Am-Be sources, obtaining about 10% deviation from linearity at 3.44 MeV. A spectral image reconstruction algorithm was tested on synthetic data. Point-like sources emitting gamma rays with energy between 2 and 7 MeV were reconstructed with 3-5 mm resolution. The two-layer Compton telescope was employed to measure radiation emitted from a beam of 150 MeV protons impinging on a cylindrical PMMA target. Bragg-peak shifts were achieved via adjustment of the PMMA target location and the resulting measurements used during image reconstruction. Reconstructed Bragg peak profiles proved sufficient to observe peak-location differences within 10 mm demonstrating the potential of the MACACO Compton Telescope as a monitoring device for ion-beam therapy.

  12. Performance of MACACO Compton telescope for ion-beam therapy monitoring: first test with proton beams

    NASA Astrophysics Data System (ADS)

    Solevi, Paola; Muñoz, Enrique; Solaz, Carles; Trovato, Marco; Dendooven, Peter; Gillam, John E.; Lacasta, Carlos; Oliver, Josep F.; Rafecas, Magdalena; Torres-Espallardo, Irene; Llosá, Gabriela

    2016-07-01

    In order to exploit the advantages of ion-beam therapy in a clinical setting, delivery verification techniques are necessary to detect deviations from the planned treatment. Efforts are currently oriented towards the development of devices for real-time range monitoring. Among the different detector concepts proposed, Compton cameras are employed to detect prompt gammas and represent a valid candidate for real-time range verification. We present the first on-beam test of MACACO, a Compton telescope (multi-layer Compton camera) based on lanthanum bromide crystals and silicon photo-multipliers. The Compton telescope was first characterized through measurements and Monte Carlo simulations. The detector linearity was measured employing 22Na and Am-Be sources, obtaining about 10% deviation from linearity at 3.44 MeV. A spectral image reconstruction algorithm was tested on synthetic data. Point-like sources emitting gamma rays with energy between 2 and 7 MeV were reconstructed with 3-5 mm resolution. The two-layer Compton telescope was employed to measure radiation emitted from a beam of 150 MeV protons impinging on a cylindrical PMMA target. Bragg-peak shifts were achieved via adjustment of the PMMA target location and the resulting measurements used during image reconstruction. Reconstructed Bragg peak profiles proved sufficient to observe peak-location differences within 10 mm demonstrating the potential of the MACACO Compton Telescope as a monitoring device for ion-beam therapy.

  13. Development of dose delivery verification by PET imaging of photonuclear reactions following high energy photon therapy

    NASA Astrophysics Data System (ADS)

    Janek, S.; Svensson, R.; Jonsson, C.; Brahme, A.

    2006-11-01

    A method for dose delivery monitoring after high energy photon therapy has been investigated based on positron emission tomography (PET). The technique is based on the activation of body tissues by high energy bremsstrahlung beams, preferably with energies well above 20 MeV, resulting primarily in 11C and 15O but also 13N, all positron-emitting radionuclides produced by photoneutron reactions in the nuclei of 12C, 16O and 14N. A PMMA phantom and animal tissue, a frozen hind leg of a pig, were irradiated to 10 Gy and the induced positron activity distributions were measured off-line in a PET camera a couple of minutes after irradiation. The accelerator used was a Racetrack Microtron at the Karolinska University Hospital using 50 MV scanned photon beams. From photonuclear cross-section data integrated over the 50 MV photon fluence spectrum the predicted PET signal was calculated and compared with experimental measurements. Since measured PET images change with time post irradiation, as a result of the different decay times of the radionuclides, the signals from activated 12C, 16O and 14N within the irradiated volume could be separated from each other. Most information is obtained from the carbon and oxygen radionuclides which are the most abundant elements in soft tissue. The predicted and measured overall positron activities are almost equal (-3%) while the predicted activity originating from nitrogen is overestimated by almost a factor of two, possibly due to experimental noise. Based on the results obtained in this first feasibility study the great value of a combined radiotherapy-PET-CT unit is indicated in order to fully exploit the high activity signal from oxygen immediately after treatment and to avoid patient repositioning. With an RT-PET-CT unit a high signal could be collected even at a dose level of 2 Gy and the acquisition time for the PET could be reduced considerably. Real patient dose delivery verification by means of PET imaging seems to be

  14. Development of dose delivery verification by PET imaging of photonuclear reactions following high energy photon therapy.

    PubMed

    Janek, S; Svensson, R; Jonsson, C; Brahme, A

    2006-11-21

    A method for dose delivery monitoring after high energy photon therapy has been investigated based on positron emission tomography (PET). The technique is based on the activation of body tissues by high energy bremsstrahlung beams, preferably with energies well above 20 MeV, resulting primarily in 11C and 15O but also 13N, all positron-emitting radionuclides produced by photoneutron reactions in the nuclei of 12C, 16O and 14N. A PMMA phantom and animal tissue, a frozen hind leg of a pig, were irradiated to 10 Gy and the induced positron activity distributions were measured off-line in a PET camera a couple of minutes after irradiation. The accelerator used was a Racetrack Microtron at the Karolinska University Hospital using 50 MV scanned photon beams. From photonuclear cross-section data integrated over the 50 MV photon fluence spectrum the predicted PET signal was calculated and compared with experimental measurements. Since measured PET images change with time post irradiation, as a result of the different decay times of the radionuclides, the signals from activated 12C, 16O and 14N within the irradiated volume could be separated from each other. Most information is obtained from the carbon and oxygen radionuclides which are the most abundant elements in soft tissue. The predicted and measured overall positron activities are almost equal (-3%) while the predicted activity originating from nitrogen is overestimated by almost a factor of two, possibly due to experimental noise. Based on the results obtained in this first feasibility study the great value of a combined radiotherapy-PET-CT unit is indicated in order to fully exploit the high activity signal from oxygen immediately after treatment and to avoid patient repositioning. With an RT-PET-CT unit a high signal could be collected even at a dose level of 2 Gy and the acquisition time for the PET could be reduced considerably. Real patient dose delivery verification by means of PET imaging seems to be

  15. Pitfalls of tungsten multileaf collimator in proton beam therapy

    SciTech Connect

    Moskvin, Vadim; Cheng, Chee-Wai; Das, Indra J.

    2011-12-15

    Purpose: Particle beam therapy is associated with significant startup and operational cost. Multileaf collimator (MLC) provides an attractive option to improve the efficiency and reduce the treatment cost. A direct transfer of the MLC technology from external beam radiation therapy is intuitively straightforward to proton therapy. However, activation, neutron production, and the associated secondary cancer risk in proton beam should be an important consideration which is evaluated. Methods: Monte Carlo simulation with FLUKA particle transport code was applied in this study for a number of treatment models. The authors have performed a detailed study of the neutron generation, ambient dose equivalent [H*(10)], and activation of a typical tungsten MLC and compared with those obtained from a brass aperture used in a typical proton therapy system. Brass aperture and tungsten MLC were modeled by absorber blocks in this study, representing worst-case scenario of a fully closed collimator. Results: With a tungsten MLC, the secondary neutron dose to the patient is at least 1.5 times higher than that from a brass aperture. The H*(10) from a tungsten MLC at 10 cm downstream is about 22.3 mSv/Gy delivered to water phantom by noncollimated 200 MeV beam of 20 cm diameter compared to 14 mSv/Gy for the brass aperture. For a 30-fraction treatment course, the activity per unit volume in brass aperture reaches 5.3 x 10{sup 4} Bq cm{sup -3} at the end of the last treatment. The activity in brass decreases by a factor of 380 after 24 h, additional 6.2 times after 40 days of cooling, and is reduced to background level after 1 yr. Initial activity in tungsten after 30 days of treating 30 patients per day is about 3.4 times higher than in brass that decreases only by a factor of 2 after 40 days and accumulates to 1.2 x 10{sup 6} Bq cm{sup -3} after a full year of operation. The daily utilization of the MLC leads to buildup of activity with time. The overall activity continues to increase

  16. Nuclear Structure Observable with Polarized Target and Polarized Real Photon Beam at Mainz Microtron

    NASA Astrophysics Data System (ADS)

    Paudyal, Dilli

    2016-09-01

    The nucleon polarizabilities are fundamental structure observables, like the nucleon mass or charge. While the electric (αE 1) and magnetic (βM 1) scalar polarizabilities of the nucleon have been measured, little effort has been made to extract the spin dependent polarizabilities. These nucleon polarizabilities, γE1E1 ,γM1M1 ,γM1E2 and γE1M2 describe the spin response of a proton to electric and magnetic dipole and quadrupole interactions. We plan to extract them using polarized photon beam and polarized target at the MAMI tagged photon facility in Mainz, Germany. This requires precise measurement of the double polarization observable ∑2 z which is sensitive to these polarizabilities. The ∑2 z is measured via a circularly polarized photon beam on a longitudinally polarized butanol target in the resonance region (E = 250 - 310 MeV). Together with constraints from αE 1 and βM 1, the forward spin polarizability (γ0) , and QCD based models, should allow us to extract all four spin polarizabilities. This presentation will be focused on the preliminary experimental results for the measurement of ∑2 z at different energies and angles. Supported by the Natural Sciences and Engineering Research Council of Canada (NSERC).

  17. Dosimetric consequences of pencil beam width variations in scanned beam particle therapy

    NASA Astrophysics Data System (ADS)

    Chanrion, M. A.; Ammazzalorso, F.; Wittig, A.; Engenhart-Cabillic, R.; Jelen, U.

    2013-06-01

    Scanned ion beam delivery enables the highest degree of target dose conformation attainable in external beam radiotherapy. Nominal pencil beam widths (spot sizes) are recorded during treatment planning system commissioning. Due to changes in the beam-line optics, the actual spot sizes may differ from these commissioning values, leading to differences between planned and delivered dose. The purpose of this study was to analyse the dosimetric consequences of spot size variations in particle therapy treatment plans. For 12 patients with skull base tumours and 12 patients with prostate carcinoma, scanned-beam carbon ion and proton treatment plans were prepared and recomputed simulating spot size changes of (1) ±10% to simulate the typical magnitude of fluctuations, (2) ±25% representing the worst-case scenario and (3) ±50% as a part of a risk analysis in case of fault conditions. The primary effect of the spot size variation was a dose deterioration affecting the target edge: loss of target coverage and broadening of the lateral penumbra (increased spot size) or overdosage and contraction of the lateral penumbra (reduced spot size). For changes ⩽25%, the resulting planning target volume mean 95%-isodose line coverage (CI-95%) deterioration was ranging from negligible to moderate. In some cases changes in the dose to adjoining critical structures were observed.

  18. Design study of a superconducting gantry for carbon beam therapy

    NASA Astrophysics Data System (ADS)

    Kim, J.; Yoon, M.

    2016-09-01

    This paper describes beam-optics design of a gantry for carbon ions in cancer therapy accelerators. A compact design is important for such a gantry. The designed gantry is compact such that its size is comparable to the size of the existing proton gantries. This is made possible by introducing superconducting double helical coils for dipole magnets. The gantry optics is designed in such a way that it provides rotation-invariant optics, a variable beam size, and point-to-parallel scanning of a beam. For large-aperture magnet, a three-dimensional magnetic field distribution is obtained by invoking a computer code, and a number of particles are tracked by integrating equations of motion numerically together with a three-dimensional interpolation. The beam-shape distortion due to the fringe field is reduced to an acceptable level by optimizing the coil windings with the help of a genetic algorithm. Higher-order transfer coefficients are calculated and shown to be reduced greatly with appropriate optimization of the coil windings.

  19. Breast Radiotherapy with Mixed Energy Photons; a Model for Optimal Beam Weighting.

    PubMed

    Birgani, Mohammadjavad Tahmasebi; Fatahiasl, Jafar; Hosseini, Seyed Mohammad; Bagheri, Ali; Behrooz, Mohammad Ali; Zabiehzadeh, Mansour; Meskani, Reza; Gomari, Maryam Talaei

    2015-01-01

    Utilization of high energy photons (>10 MV) with an optimal weight using a mixed energy technique is a practical way to generate a homogenous dose distribution while maintaining adequate target coverage in intact breast radiotherapy. This study represents a model for estimation of this optimal weight for day to day clinical usage. For this purpose, treatment planning computed tomography scans of thirty-three consecutive early stage breast cancer patients following breast conservation surgery were analyzed. After delineation of the breast clinical target volume (CTV) and placing opposed wedge paired isocenteric tangential portals, dosimeteric calculations were conducted and dose volume histograms (DVHs) were generated, first with pure 6 MV photons and then these calculations were repeated ten times with incorporating 18 MV photons (ten percent increase in weight per step) in each individual patient. For each calculation two indexes including maximum dose in the breast CTV (Dmax) and the volume of CTV which covered with 95% Isodose line (VCTV, 95%IDL) were measured according to the DVH data and then normalized values were plotted in a graph. The optimal weight of 18 MV photons was defined as the intersection point of Dmax and VCTV, 95%IDL graphs. For creating a model to predict this optimal weight multiple linear regression analysis was used based on some of the breast and tangential field parameters. The best fitting model for prediction of 18 MV photons optimal weight in breast radiotherapy using mixed energy technique, incorporated chest wall separation plus central lung distance (Adjusted R2=0.776). In conclusion, this study represents a model for the estimation of optimal beam weighting in breast radiotherapy using mixed photon energy technique for routine day to day clinical usage.

  20. SU-E-T-142: Effect of the Bone Heterogeneity On the Unflattened and Flattened Photon Beam Dosimetry: A Monte Carlo Comparison

    SciTech Connect

    Chow, J; Owrangi, A

    2014-06-01

    Purpose: This study compared the dependence of depth dose on bone heterogeneity of unflattened photon beams to that of flattened beams. Monte Carlo simulations (the EGSnrc-based codes) were used to calculate depth doses in phantom with a bone layer in the buildup region of the 6 MV photon beams. Methods: Heterogeneous phantom containing a bone layer of 2 cm thick at a depth of 1 cm in water was irradiated by the unflattened and flattened 6 MV photon beams (field size = 10×10 cm{sup 2}). Phase-space files of the photon beams based on the Varian TrueBeam linac were generated by the Geant4 and BEAMnrc codes, and verified by measurements. Depth doses were calculated using the DOSXYZnrc code with beam angles set to 0° and 30°. For dosimetric comparison, the above simulations were repeated in a water phantom using the same beam geometry with the bone layer replaced by water. Results: Our results showed that the beam output of unflattened photon beams was about 2.1 times larger than the flattened beams in water. Comparing the water phantom to the bone phantom, larger doses were found in water above and below the bone layer for both the unflattened and flattened photon beams. When both beams were turned 30°, the deviation of depth dose between the bone and water phantom became larger compared to that with beam angle equal to 0°. Dose ratio of the unflattened and flattened photon beams showed that the unflattened beam has larger depth dose in the buildup region compared to the flattened beam. Conclusion: Although the unflattened photon beam had different beam output and quality compared to the flattened, dose enhancements due to the bone scatter were found similar. However, we discovered that depth dose deviation due to the presence of bone was sensitive to the beam obliquity.

  1. The clinical potential of high energy, intensity and energy modulated electron beams optimized by simulated annealing for conformal radiation therapy

    NASA Astrophysics Data System (ADS)

    Salter, Bill Jean, Jr.

    Purpose. The advent of new, so called IVth Generation, external beam radiation therapy treatment machines (e.g. Scanditronix' MM50 Racetrack Microtron) has raised the question of how the capabilities of these new machines might be exploited to produce extremely conformal dose distributions. Such machines possess the ability to produce electron energies as high as 50 MeV and, due to their scanned beam delivery of electron treatments, to modulate intensity and even energy, within a broad field. Materials and methods. Two patients with 'challenging' tumor geometries were selected from the patient archives of the Cancer Therapy and Research Center (CTRC), in San Antonio Texas. The treatment scheme that was tested allowed for twelve, energy and intensity modulated beams, equi-spaced about the patient-only intensity was modulated for the photon treatment. The elementary beams, incident from any of the twelve allowed directions, were assumed parallel, and the elementary electron beams were modeled by elementary beam data. The optimal arrangement of elementary beam energies and/or intensities was optimized by Szu-Hartley Fast Simulated Annealing Optimization. Optimized treatment plans were determined for each patient using both the high energy, intensity and energy modulated electron (HIEME) modality, and the 6 MV photon modality. The 'quality' of rival plans were scored using three different, popular objective functions which included Root Mean Square (RMS), Maximize Dose Subject to Dose and Volume Limitations (MDVL - Morrill et. al.), and Probability of Uncomplicated Tumor Control (PUTC) methods. The scores of the two optimized treatments (i.e. HIEME and intensity modulated photons) were compared to the score of the conventional plan with which the patient was actually treated. Results. The first patient evaluated presented a deeply located target volume, partially surrounding the spinal cord. A healthy right kidney was immediately adjacent to the tumor volume, separated

  2. Proton beam writing of long, arbitrary structures for micro/nano photonics and fluidics applications

    NASA Astrophysics Data System (ADS)

    Udalagama, Chammika; Teo, E. J.; Chan, S. F.; Kumar, V. S.; Bettiol, A. A.; Watt, F.

    2011-10-01

    The last decade has seen proton beam writing maturing into a versatile lithographic technique able to produce sub-100 nm, high aspect ratio structures with smooth side walls. However, many applications in the fields of photonics and fluidics require the fabrication of structures with high spatial resolution that extends over several centimetres. This cannot be achieved by purely magnetic or electrostatic beam scanning due to the large off-axis beam aberrations in high demagnification systems. As a result, this has limited us to producing long straight structures using a combination of beam and stage scanning. In this work we have: (1) developed an algorithm to include any arbitrary pattern into the writing process by using a more versatile combination of beam and stage scanning while (2) incorporating the use of the ubiquitous AutoCAD DXF (drawing exchange format) into the design process. We demonstrate the capability of this approach in fabricating structures such as Y-splitters, Mach-Zehnder modulators and microfluidic channels that are over several centimetres in length, in polymer. We also present optimisation of such parameters as scanning speed and scanning loops to improve on the surface roughness of the structures. This work opens up new possibilities of using CAD software in PBW for microphotonics and fluidics device fabrication.

  3. Spin-orbit photonic interaction engineering of Bessel beams (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Aleksanyan, Artur; Brasselet, Etienne

    2016-09-01

    Interaction between the polarization and spatial degrees of freedom of a light field has become a powerful tool to tailor the amplitude and phase of light beams. This usually implies the use of space-variant photonic elements involving sophisticated fabrication technologies. Here we report on the optical spin-orbit engineering of the intensity, phase, and polarization structure of Bessel light beams using a homogeneous birefringent axicon. Various kinds of spatially modulated free-space light fields are predicted depending on the nature of the incident light field impinging on the birefringent axicon. In particular, we present the generation of bottle beam arrays, hollow beams with periodic modulation of the core size, and hollow needle beams with periodic modulation of the orbital angular momentum. An experimental attempt is also reported. The proposed structured light fields may find applications in long-distance optical manipulation endowed with self-healing features, periodic atomic waveguides, contactless handling of high aspect ratio micro-objects, and optical shearing of matter.

  4. Comparisons of the Codes of Practice IAEA TRS 277 and TRS 398: High Energy Photons and Electron Beams

    NASA Astrophysics Data System (ADS)

    Gutiérrez-Castillo, J. G.; Torres-Calderón, A.; Fragoso-Valdéz, F. R.; Álvarez-Romero, J. T.

    2004-09-01

    This work presents the calibration for: 6, 8, 10, 12, 14, 15 and 18 MeV electron beams, also to 6 and 15 MV photons beams. Beams that are generated by an accelerator Elekta Linac SL 18. The calibration is performed in terms of absorbed dose to water Dw. It is determined by two different protocols: the code of practice of the International Atomic Energy Agency (IAEA) TRS 277 for ionization chambers calibrated on air kerma NK, and the code of practice TRS 398 for ionization chambers calibrated on absorbed dose to water ND,W. Two independent dosimeters were used with two ionization chambers each one, respectively. The first one, a dosimeter PTW model UNIDOS with Markus type chamber (plane parallel) for electrons, and Farmer type chamber (cylindrical) for photons, both chambers calibrated in NK. The second dosimeter Scanditronix model DOSE 1 with plane parallel chamber (electrons) and cylindrical chamber (photons), both chambers calibrated in terms of ND,W. In the case of photon beams, the TPR was measured for 6 and 15 MV, also the profiles were determined in order to verify the flatness and symmetry of the beam: ±3%. The quality for electrons beams were estimated by means of the Dmax, R80, R50 and Rp. The results obtained for the absorbed dose quotients DW,Q(dmax)277398 are: Electrons, 0.976⩽ DW,Q(dmax)277398⩽ 1.001; Photons: 1.001 ⩽ DW,Q(dmax)277398 ⩽ 1.003.

  5. Combined photon-electron beams in the treatment of the supraclavicular lymph nodes in breast cancer: A novel technique that achieves adequate coverage while reducing lung dose.

    PubMed

    Salem, Ahmed; Mohamad, Issa; Dayyat, Abdulmajeed; Kanaa'n, Haitham; Sarhan, Nasim; Roujob, Ibrahim; Salem, Abdel-Fattah; Afifi, Shatha; Jaradat, Imad; Mubiden, Rasmi; Almousa, Abdelateif

    2015-01-01

    Radiation pneumonitis is a well-documented side effect of radiation therapy for breast cancer. The purpose of this study was to compare combined photon-electron, photon-only, and electron-only plans in the radiation treatment of the supraclavicular lymph nodes. In total, 13 patients requiring chest wall and supraclavicular nodal irradiation were planned retrospectively using combined photon-electron, photon-only, and electron-only supraclavicular beams. A dose of 50Gy over 25 fractions was prescribed. Chest wall irradiation parameters were fixed for all plans. The goal of this planning effort was to cover 95% of the supraclavicular clinical target volume (CTV) with 95% of the prescribed dose and to minimize the volume receiving ≥ 105% of the dose. Comparative end points were supraclavicular CTV coverage (volume covered by the 95% isodose line), hotspot volume, maximum radiation dose, contralateral breast dose, mean total lung dose, total lung volume percentage receiving at least 20 Gy (V(20 Gy)), heart volume percentage receiving at least 25 Gy (V(25 Gy)). Electron and photon energies ranged from 8 to 18 MeV and 4 to 6 MV, respectively. The ratio of photon-to-electron fractions in combined beams ranged from 5:20 to 15:10. Supraclavicular nodal coverage was highest in photon-only (mean = 96.2 ± 3.5%) followed closely by combined photon-electron (mean = 94.2 ± 2.5%) and lowest in electron-only plans (mean = 81.7 ± 14.8%, p < 0.001). The volume of tissue receiving ≥ 105% of the prescription dose was higher in the electron-only (mean = 69.7 ± 56.1 cm(3)) as opposed to combined photon-electron (mean = 50.8 ± 40.9 cm(3)) and photon-only beams (mean = 32.2 ± 28.1 cm(3), p = 0.114). Heart V(25 Gy) was not statistically different among the plans (p = 0.999). Total lung V(20 Gy) was lowest in electron-only (mean = 10.9 ± 2.3%) followed by combined photon-electron (mean = 13.8 ± 2.3%) and highest in photon-only plans (mean = 16.2 ± 3%, p < 0.001). As expected

  6. Combined photon-electron beams in the treatment of the supraclavicular lymph nodes in breast cancer: A novel technique that achieves adequate coverage while reducing lung dose

    SciTech Connect

    Salem, Ahmed; Mohamad, Issa; Dayyat, Abdulmajeed; Kanaa’n, Haitham; Sarhan, Nasim; Roujob, Ibrahim; Salem, Abdel-Fattah; Afifi, Shatha; Jaradat, Imad; Mubiden, Rasmi; Almousa, Abdelateif

    2015-10-01

    Radiation pneumonitis is a well-documented side effect of radiation therapy for breast cancer. The purpose of this study was to compare combined photon-electron, photon-only, and electron-only plans in the radiation treatment of the supraclavicular lymph nodes. In total, 13 patients requiring chest wall and supraclavicular nodal irradiation were planned retrospectively using combined photon-electron, photon-only, and electron-only supraclavicular beams. A dose of 50 Gy over 25 fractions was prescribed. Chest wall irradiation parameters were fixed for all plans. The goal of this planning effort was to cover 95% of the supraclavicular clinical target volume (CTV) with 95% of the prescribed dose and to minimize the volume receiving ≥ 105% of the dose. Comparative end points were supraclavicular CTV coverage (volume covered by the 95% isodose line), hotspot volume, maximum radiation dose, contralateral breast dose, mean total lung dose, total lung volume percentage receiving at least 20 Gy (V{sub 20} {sub Gy}), heart volume percentage receiving at least 25 Gy (V{sub 25} {sub Gy}). Electron and photon energies ranged from 8 to 18 MeV and 4 to 6 MV, respectively. The ratio of photon-to-electron fractions in combined beams ranged from 5:20 to 15:10. Supraclavicular nodal coverage was highest in photon-only (mean = 96.2 ± 3.5%) followed closely by combined photon-electron (mean = 94.2 ± 2.5%) and lowest in electron-only plans (mean = 81.7 ± 14.8%, p < 0.001). The volume of tissue receiving ≥ 105% of the prescription dose was higher in the electron-only (mean = 69.7 ± 56.1 cm{sup 3}) as opposed to combined photon-electron (mean = 50.8 ± 40.9 cm{sup 3}) and photon-only beams (mean = 32.2 ± 28.1 cm{sup 3}, p = 0.114). Heart V{sub 25} {sub Gy} was not statistically different among the plans (p = 0.999). Total lung V{sub 20} {sub Gy} was lowest in electron-only (mean = 10.9 ± 2.3%) followed by combined photon-electron (mean = 13.8 ± 2.3%) and highest in photon

  7. Propagation of an X-ray beam modified by a photonic crystal.

    PubMed

    Kohn, V G; Snigireva, I; Snigirev, A

    2014-07-01

    A method of calculating the transmission of hard X-ray radiation through a perfect and well oriented photonic crystal and the propagation of the X-ray beam modified by a photonic crystal in free space is developed. The method is based on the approximate solution of the paraxial equation at short distances, from which the recurrent formula for X-ray propagation at longer distances is derived. A computer program for numerical simulation of images of photonic crystals at distances just beyond the crystal up to several millimetres was created. Calculations were performed for Ni inverted photonic crystals with the [111] axis of the face-centred-cubic structure for distances up to 0.4 mm with a step size of 4 µm. Since the transverse periods of the X-ray wave modulation are of several hundred nanometres, the intensity distribution of such a wave is changed significantly over the distance of several micrometres. This effect is investigated for the first time.

  8. Studies of a proton phase beam monitor for range verification in proton therapy

    SciTech Connect

    Werner, T.; Golnik, C.; Enghardt, W.; Petzoldt, J.; Kormoll, T.; Pausch, G.; Straessner, A.; Roemer, K.; Dreyer, A.; Hueso-Gonzalez, F.; Enghardt, W.

    2015-07-01

    A primary subject of the present research in particle therapy is to ensure the precise irradiation of the target volume. The prompt gamma timing (PGT) method provides one possibility for in vivo range verification during the irradiation of patients. Prompt gamma rays with high energies are emitted promptly due to nuclear reactions of protons with tissue. The arrival time of these gammas to the detector reflects the stopping process of the primary protons in tissue and are directly correlated to the range. Due to the time resolution of the detector and the proton bunch time spread, as well as drifts of the bunch phase with respect to the accelerator frequency, timing spectra are smeared out and compromise the accuracy of range information intended for future clinical applications. Nevertheless, counteracting this limitation and recovering range information from the PGT measured spectra, corrections using a phase beam monitor can be performed. A first prototype of phase beam monitor was tested at GSI Darmstadt, where measurements of the energy profile of the ion bunches were performed. At the ELBE accelerator Helmholtz-Zentrum Dresden-Rossendorf (HZDR), set up to provide bremsstrahlung photons in very short pulses, a constant fraction algorithm for the incoming digital signals was evaluated, which is used for optimizing the time resolution. Studies of scattering experiments with different thin targets and detector positions are accomplished at Oncoray Dresden, where a clinical proton beam is available. These experiments allow a basic characterization of the proton bunch structure and the detection yield. (authors)

  9. Why diamond dimensions and electrode geometry are crucial for small photon beam dosimetry

    SciTech Connect

    Marsolat, F.; Tromson, D.; Tranchant, N.; Pomorski, M.; Bergonzo, P.; Bassinet, C.; Huet, C.; Buchheit, I.; Marchesi, V.; Gaudaire-Josset, S.; Lisbona, A.; Lazaro, D.; Hugon, R.

    2015-12-21

    Recent use of very small photon beams (down to 4 mm) in stereotactic radiotherapy requires new detectors to accurately determine the delivered dose. Diamond detectors have been presented in the literature as an attractive candidate for this application, due to their small detection volume and the diamond atomic number (Z = 6) which is close to water effective atomic number (Zeff ∼ 7.42). However, diamond exhibits a density 3.51 times greater than that of water and recent studies using Monte Carlo simulations have demonstrated the drawback of a high-density detector on small beam output factors. The current study focuses on geometrical parameters of diamond detector, namely, the diamond dimensions and the electrode geometry, in order to solve the dosimetric issues still observed in small photon beams with diamond detectors. To give better insights to these open questions, we have used both computational method and experimental analysis. This study highlighted that reducing diamond dimensions is crucial for small beam output factor measurements and to limit the influence of its high density. Furthermore, electrodes covering the whole diamond surface were essential for a dose rate independence of the diamond detector. The optimal dosimeter derived from this work presented small diamond dimensions of approximately 1 × 1 × 0.15 mm{sup 3}, with diamond-like-carbon electrodes covering the whole diamond surface. A dose rate independence of this diamond detector (better than 0.5% over a wide range of dose rates available on a stereotactic dedicated facility) was obtained due to the electrode geometry. Concerning the output factor measurements, a good agreement (better than 1.1%) was observed between this carbon material detector and two types of passive dosimeters (LiF microcubes and EBT2 radiochromic films) for all beam sizes except the smallest field of 0.6 × 0.6 cm{sup 2} with a deviation of 2.6%. This new study showed the high performance

  10. A feasibility study of Dynamic Phantom scanner for quality assurance of photon beam profiles at various gantry angles.

    PubMed

    Zhang, Yunkai; Hsi, Wen C; Chu, James C H; Bernard, Damian B; Abrams, Ross A

    2005-01-01

    The effect of gantry rotation on beam profiles of photon and electron beams is an important issue in quality assurance for radiotherapy. To address variations in the profiles of photon and electron beams at different gantry angles, a Dynamic Phantom scanner composed of a 20 x 12 x 6 cm3 scanning Lucite block was designed as a cross-beam-profile scanner. To our knowledge, differences between scanned profiles acquired at different gantry angles with a small size Lucite block and those acquired a full-size (60 x 60 x 50 cm3) water phantom have not been previously investigated. We therefore performed a feasibility study for a first prototype Dynamic Phantom scanner without a gantry attachment mount. Radiation beams from a Varian LINAC 21EX and 2100C were used. Photon beams (6 MV and 18 MV) were shaped by either collimator jaws or a Varian 120 Multileaf (MLC) collimator, and electron beams (6 MeV, 12 MeV, and 20 MeV) were shaped by a treatment cone. To investigate the effect on profiles by using a Lucite block, a quantitative comparison of scanned profiles with the Dynamic Phantom and a full-size water phantom was first performed at a 0 degrees gantry angle for both photon and electron beams. For photon beam profiles defined by jaws at 1.0 cm and 5.0 cm depths of Lucite (i.e., at 1.1 cm and 5.7 cm depth of water), a good agreement (less than 1% variation) inside the field edge was observed between profiles scanned with the Dynamic Phantom and with a water phantom. The use of Lucite in the Dynamic Phantom resulted in reduced penumbra width (about 0.5 mm out of 5 mm to 8mm) and reduced (1% to 2%) scatter dose beyond the field edges for both 6 MV and 18 MV beams, compared with the water phantom scanner. For profiles of the MLC-shaped 6 MV photon beam, a similar agreement was observed. For profiles of electron beams scanned at 2.9 cm depth of Lucite (i.e., at 3.3 cm depth of water), larger disagreements in profiles (3% to 4%) and penumbra width (3 mm to 4 mm out of 12 mm

  11. Photon beam dose distributions for patients with implanted temporary tissue expanders

    NASA Astrophysics Data System (ADS)

    Asena, A.; Kairn, T.; Crowe, S. B.; Trapp, J. V.

    2015-01-01

    This study examines the effects of temporary tissue expanders (TTEs) on the dose distributions of photon beams in breast cancer radiotherapy treatments. EBT2 radiochromic film and ion chamber measurements were taken to quantify the attenuation and backscatter effects of the inhomogeneity. Results illustrate that the internal magnetic port present in a tissue expander causes a dose reduction of approximately 25% in photon tangent fields immediately downstream of the implant. It was also shown that the silicone elastomer shell of the tissue expander reduced the dose to the target volume by as much as 8%. This work demonstrates the importance for an accurately modelled high-density implant in the treatment planning system for post-mastectomy breast cancer patients.

  12. Shielding and Radiation Protection in Ion Beam Therapy Facilities

    NASA Astrophysics Data System (ADS)

    Wroe, Andrew J.; Rightnar, Steven

    Radiation protection is a key aspect of any radiotherapy (RT) department and is made even more complex in ion beam therapy (IBT) by the large facility size, secondary particle spectra and intricate installation of these centers. In IBT, large and complex radiation producing devices are used and made available to the public for treatment. It is thus the responsibility of the facility to put in place measures to protect not only the patient but also the general public, occupationally and nonoccupationally exposed personnel working within the facility, and electronics installed within the department to ensure maximum safety while delivering maximum up-time.

  13. Instrumentation and Beam Dynamics Study of Advanced Electron-Photon Facility in Indiana University

    SciTech Connect

    Luo, Tianhuan

    2011-08-01

    The Advanced eLectron-PHoton fAcility (ALPHA) is a compact electron accelerator under construction and being commissioned at the Indiana University Center for Exploration of Energy and Matter (CEEM). In this thesis, we have studied the refurbished Cooler Injector Synchrotron (CIS) RF cavity using both the transmission line model and SUPERFISH simulation. Both low power and high power RF measurements have been carried out to characterize the cavity. Considering the performance limit of ferrite, we have designed a new ferrite loaded, co-axial quarter wave like cavity with similar structure but a more suitable ferrite material. We have also designed a traveling wave stripline kicker for fast extraction by POISSON and Microwave Studio. The strips geometry is trimmed to maximize the uniformity of the kicking field and match the impedance of the power cables. The time response simulation shows the kicker is fast enough for machine operation. The pulsed power supply requirement has also been specified. For the beam diagnosis in the longitudinal direction, we use a wideband Wall Gap Monitor (WGM) served in CIS. With proper shielding and amplification to get good WGM signal, we have characterized the injected and extracted beam signal in single pass commissioning, and also verified the debunching effect of the ALPHA storage ring. A modulation-demodulation signal processing method is developed to measure the current and longitudinal profile of injected beam. By scanning the dipole strength in the injection line, we have reconstructed the tomography of the longitudinal phase space of the LINAC beam. In the accumulation mode, ALPHA will be operated under a low energy and high current condition, where intra beam scattering (IBS) becomes a dominant effect on the beam emittance. A self consistent simulation, including IBS effect, gas scattering and linear coupling, has been carried out to calculate the emittance of the stored beam.

  14. Efficiency improvements for ion chamber calculations in high energy photon beams

    SciTech Connect

    Wulff, J.; Zink, K.; Kawrakow, I.

    2008-04-15

    This article presents the implementation of several variance reduction techniques that dramatically improve the simulation efficiency of ion chamber dose and perturbation factor calculations. The cavity user code for the EGSnrc Monte Carlo code system is extended by photon cross-section enhancement (XCSE), an intermediate phase-space storage (IPSS) technique, and a correlated sampling (CS) scheme. XCSE increases the density of photon interaction sites inside and in the vicinity of the chamber and results - in combination with a Russian Roulette game for electrons that cannot reach the cavity volume - in an increased efficiency of up to a factor of 350 for calculating dose in a Farmer type chamber placed at 10 cm depth in a water phantom. In combination with the IPSS and CS techniques, the efficiency for the calculation of the central electrode perturbation factor P{sub cel} can be increased by up to three orders of magnitude for a single chamber location and by nearly four orders of magnitude when considering the P{sub cel} variation with depth or with distance from the central axis in a large field photon beam. The intermediate storage of the phase-space properties of particles entering a volume that contains many possible chamber locations leads to efficiency improvements by a factor larger than 500 when computing a profile of chamber doses in the field of a linear accelerator photon beam. All techniques are combined in a new EGSnrc user code egs{sub c}hamber. Optimum settings for the variance reduction parameters are investigated and are reported for a Farmer type ion chamber. A few example calculations illustrating the capabilities of the egs{sub c}hamber code are presented.

  15. Design and fabrication of Si-based photonic crystal stamps with electron beam lithography (EBL)

    NASA Astrophysics Data System (ADS)

    Jannesary, Reyhaneh; Bergmair, Iris; Zamiri, Saeid; Hingerl, Kurt; Hubbard, Graham; Abbott, Steven; Chen, Qin; Allsopp, Duncan

    2009-05-01

    The quest for mass replication has established technologies like nanoimprinting via hard stamps or PDMS stamps, where the stamps are usually produced via Electron Beam Lithography (EBL) for applications in the microelectronic industry. On the other hand, nanopatterning with self ordered structures1 or via holographic patterns provide the basis for large area imprints for applications for example, antireflection coatings based on biomimetic motheyes2. In this work we report on a technology for enabling the mass replication of custom-designed and e-beam lithographically prepared structures via establishing novel roll to roll nanoimprint processes for pattern transfer into UV curable pre-polymers. The new nano-fabrication technology is based on the concept of Disposal Master Technology (DMT) capable of patterning areas up to 1 x 1 m2 and is suitable for mass volume manufacturing of large area arrays of sub-wavelength photonic elements. As an example to show the potential of the application of the new nanoimprint technologies, we choose the fabrication of a photonic crystal (PhC) structure with integrated light coupling devices for low loss interconnection between PhC lightwave circuits and optical fibre systems. We present two methods for fabrication of nanoimprint lithography stamps in Si substrate. In the first method optimized electron beam lithography (EBL) and lift-off patterning of a 15-nm thick Cr mask, and then the pattern transfer into Si using reacting ion etching (RIE) with SF6 as etch gas. In the first method, we use 200nm of positive resist PMMA 950K for EBL exposure. In this method, resist thickness, exposure dose, development time and parameter for etching have been optimized and a photonic crystal of Si-rods in air was fabricated. In the second method lift-off has not been performed and metal mask has been used as master. The subsequent steps for fabricating the master will be presented in detail.

  16. Heuristic optimization of the scanning path of particle therapy beams.

    PubMed

    Pardo, J; Donetti, M; Bourhaleb, F; Ansarinejad, A; Attili, A; Cirio, R; Garella, M A; Giordanengo, S; Givehchi, N; La Rosa, A; Marchetto, F; Monaco, V; Pecka, A; Peroni, C; Russo, G; Sacchi, R

    2009-06-01

    Quasidiscrete scanning is a delivery strategy for proton and ion beam therapy in which the beam is turned off when a slice is finished and a new energy must be set but not during the scanning between consecutive spots. Different scanning paths lead to different dose distributions due to the contribution of the unintended transit dose between spots. In this work an algorithm to optimize the scanning path for quasidiscrete scanned beams is presented. The classical simulated annealing algorithm is used. It is a heuristic algorithm frequently used in combinatorial optimization problems, which allows us to obtain nearly optimal solutions in acceptable running times. A study focused on the best choice of operational parameters on which the algorithm performance depends is presented. The convergence properties of the algorithm have been further improved by using the next-neighbor algorithm to generate the starting paths. Scanning paths for two clinical treatments have been optimized. The optimized paths are found to be shorter than the back-and-forth, top-to-bottom (zigzag) paths generally provided by the treatment planning systems. The gamma method has been applied to quantify the improvement achieved on the dose distribution. Results show a reduction of the transit dose when the optimized paths are used. The benefit is clear especially when the fluence per spot is low, as in the case of repainting. The minimization of the transit dose can potentially allow the use of higher beam intensities, thus decreasing the treatment time. The algorithm implemented for this work can optimize efficiently the scanning path of quasidiscrete scanned particle beams. Optimized scanning paths decrease the transit dose and lead to better dose distributions.

  17. In vitro studies of the efficiency of two-photon activation of photodynamic therapy agents

    NASA Astrophysics Data System (ADS)

    Khurana, Mamta; Karotki, Aliaksandr; Collins, Hazel; Anderson, Harry L.; Wilson, Brian C.

    2006-09-01

    Age related macular degeneration (AMD) is a major cause of severe vision loss in the older population, due to ingrowth of new leaky blood vessels (neovasculature) from the choriocapillaris, which results in destruction of photoreceptors in the fovea and loss of central vision. "Standard" one-photon (1-γ) photodynamic therapy (PDT) using Visudyne (R) is an approved method of AMD treatment but has the potential to damage healthy tissues lying above and below the neovasculature due to photosensitizer accumulation and its wide-beam 1-γ excitation. Highly-targeted two-photon (2-γ) excitation may avoid this, since, due to its non-linear intensity dependence, the probability of 2-γ excitation is greatest in the focal plane, which intrinsically avoids out-of-focus damage to healthy tissues. The aim of the present study is to evaluate the 2-γ efficiency of Visudyne and to compare it to the archetypal photosensitizer Photofrin (R). Since neovascular endothelium is targeted in AMD, an endothelial cell line (YPEN-1) was selected as the in vitro model. 2-γ PDT was delivered using tightly focused ~300 fs laser pulses from a Ti:sapphire laser operating at 850 nm with 90 MHz pulse repetition rate. An assay was developed for quantification of the cellular damage using the permeability stain Hoechst 33258 and the viability stain SYTOX. Visudyne (LD 50= dose to kill 50% of cells: 500 J/cm2, 10 M, 7.2 μg/ml) was about an order of magnitude more effective than Photofrin (LD50 : 7500 J/cm2, ~42 μM, 25 μg/ml). We also demonstrate for the first time the quadratic dependence of the cellular response to 2-γ PDT. This in vitro work will lead to the design of optimized in vivo studies in animal models of AMD.

  18. Partial wave analysis of 3 π with pion and photon beams

    NASA Astrophysics Data System (ADS)

    Jackura, Andrew; Mikhasenko, Mikhail; Szczepaniak, Adam; Ketzer, Bernhard; Joint Physics Analysis Center Collaboration

    2016-09-01

    We present some results on the analysis of 3 π resonances from peripheral scattering of pions off of nuclear targets. The analysis is motivated by the recent release of the largest data set on diffractively produced three pions by the COMPASS collaboration. The model emphasizes the 3 π production process and their final state interactions which satisfy S-matrix principles. We apply our model to fit partial wave intensities and relative phases from COMPASS in the JPC =2-+ sector and search for resonances. We then discuss the extension of our formalism to photon beams to be used in the GlueX experiment.

  19. Dirac leaky-wave antennas for continuous beam scanning from photonic crystals.

    PubMed

    Memarian, Mohammad; Eleftheriades, George V

    2015-01-05

    Leaky-Wave Antennas (LWAs) enable directive and scannable radiation patterns, which are highly desirable attributes at terahertz, infrared and optical frequencies. However, a LWA is generally incapable of continuous beam scanning through broadside, due to an open stopband in its dispersion characteristic. This issue is yet to be addressed at frequencies beyond microwaves, mainly as existing microwave solutions (for example, transmission line metamaterials) are unavailable at these higher frequencies. Here we report leaky-wave radiation from the interface of a photonic crystal (PC) with a Dirac-type dispersion and air. The resulting Dirac LWA (DLWA) can radiate at broadside, chiefly owing to the closed Γ-point bandgap of the Dirac PC. Thus, the DLWA can continuously scan a directive beam over a wide range of angles by varying the frequency. These DLWAs can be designed at microwave as well as terahertz to optical frequencies, with feasible dimensions and low losses.

  20. Study on the consistency of the voxel of two photon polymerization with inclined beam

    NASA Astrophysics Data System (ADS)

    Cheng, Kai; Zhou, Xiaoqin; Zheng, Xu; Lin, Jieqiong

    2016-12-01

    In the process of two photon polymerization, the focused beam should be perpendicular to the materials to be processed. But actually it is hard to control, because of the errors of the optical system and the three-dimensional motion platform. So, the inconsistencies of voxels in size and angle due to the errors mentioned above will seriously impact the surface quality of the products. In this paper, the size, angle and location of the titled voxels formed by inclined beam are simulated according to matrix optics and polymerization theory. According to the simulation results, a method for angle errors compensation with the aid of scanning galvanometer is proposed. Although the angle of the voxels can be controlled by scanning galvanometer, but the deflection angles of the scanning galvanometer have a certain range, it should be lower than 3°, or the deformation of the voxels will be serious. Therefore the consistency of the voxel in both size and angle will be ensured.

  1. Characteristics of an 18 MV photon beam from a Therac 20 Medical Linear Accelerator.

    PubMed

    Patterson, M S; Shragge, P C

    1981-01-01

    The 18 MV photon beam characteristics of a Therac 20 Medical Linear Accelerator manufactured by Atomic Energy of Canada Ltd, are presented. Tissue phantom ratios (TRP's) and percent depth dose data are given; for a 10 x 10 cm field, the percent depth dose at a depth of 10 cm is 78.5 (SSD 100 cm). The relative dose factors (RDF'S) are given and are analyzed to elucidate the relative contributions from phantom scatter, collimator scatter, and backscatter from the top of the collimators into the monitor chambers. The effect of field size and depth on the penumbra is described. Crossplots of the beam at a depth of 5 cm indicate that the flattening filter could be improved; there are hot spots of 108% near the corners of 40 x 40 fields.

  2. Characteristics of an 18 MV photon beam from a Therac 20 Medical Linear Accelerator

    SciTech Connect

    Patterson, M.S.; Shragge, P.C.

    1981-05-01

    The 18 MV photon beam characteristics of a Therac 20 Medical Linear Accelerator manufactured by Atomic Energy of Canada Ltd, are presented. Tissue phantom ratios (TPR's) and percent depth dose data are given; for a 10 x 10 cm field, the percent depth dose at a depth of 10 cm is 78.5 (SSD 100 cm). The relative dose factors (RDF'S) are given and are analyzed to elucidate the relative contributions from phantom scatter, collimator scatter, and backscatter from the top of the collimators into the monitor chambers. The effect of field size and depth on the penumbra is described. Crossplots of the beam at a depth of 5 cm indicate that the flattening filter could be improved; there are hot spots of 108% near the corners of 40 x 40 fields.

  3. Two-dimensional beam steering using a thermo-optic silicon photonic optical phased array

    NASA Astrophysics Data System (ADS)

    Rabinovich, William S.; Goetz, Peter G.; Pruessner, Marcel W.; Mahon, Rita; Ferraro, Mike S.; Park, Doe; Fleet, Erin; DePrenger, Michael J.

    2016-11-01

    Many components for free-space optical (FSO) communication systems have shrunken in size over the last decade. However, the steering systems have remained large and power hungry. Nonmechanical beam steering offers a path to reducing the size of these systems. Optical phased arrays can allow integrated beam steering elements. One of the most important aspects of an optical phased array technology is its scalability to a large number of elements. Silicon photonics can potentially offer this scalability using CMOS foundry techniques. A phased array that can steer in two dimensions using the thermo-optic effect is demonstrated. No wavelength tuning of the input laser is needed and the design allows a simple control system with only two inputs. A benchtop FSO link with the phased array in both transmit and receive mode is demonstrated.

  4. Optimization of photon beam energy in aperture-based inverse planning.

    PubMed

    St-Hilaire, Jason; Sévigny, Caroline; Beaulieu, Frédéric; Gingras, Luc; Tremblay, Daniel; Beaulieu, Luc

    2009-09-03

    Optimal choice of beam energy in radiation therapy is easy in many well-documented cases, but less obvious in some others. Low-energy beams may provide better conformity around the target than their high-energy counterparts due to reduced lateral scatter, but they also contribute to overdosage of peripheral normal tissue. Beam energy was added as an optimization parameter in an automatic aperture-based inverse planning system. We have investigated two sites (prostate and lung), representative of deep-seated and moderately deep-seated tumors. For each case and different numbers of beam incidences, four plans were optimized: 6 MV, 23 MV, and mixed energy plans with one or two energies per incidence. Each plan was scored with a dose-volume cost function. Cost function values, number of segments, monitor units, dose-volume parameters and isodose distributions were compared. For the prostate and lung cases, energy mixing improved plans in terms of cost function values, with a more important reduction for a small number of beam incidences. Use of high energy allows better peripheral tissue sparing, while keeping similar target coverage and sensitive structures avoidance. Low energy contribution to monitor units usually increased with the number of beam incidences. Thus, for deep-seated and moderately deep-seated tumors, energy optimization can produce interesting plans with less peripheral dose and monitor units than for low energy alone.

  5. Characteristics of kilovoltage x-ray beams used for cone-beam computed tomography in radiation therapy.

    PubMed

    Ding, George X; Duggan, Dennis M; Coffey, Charles W

    2007-03-21

    The purpose of this investigation is to characterize the beams produced by a kilovoltage (kV) imager integrated into a linear accelerator (Varian on-board imager integrated into the Trilogy accelerator) for acquiring high resolution volumetric cone-beam computed tomography (CBCT) images of the patient on the treatment table. The x-ray tube is capable of generating photon spectra with kVp values between 40 and 125 kV. The Monte Carlo simulations were used to study the characteristics of kV beams and the properties of imaged target scatters. The Monte Carlo results were benchmarked against measurements, and excellent agreements were obtained. We also studied the effect of including the electron impact ionization (EII), and the simulation showed that the characteristic radiation is increased significantly in the energy spectra when EII is included. Although only slight beam hardening is observed in the spectra of all photons after passing through the phantom target, there is a significant difference in the spectra and angular distributions between scattered and primary photons. The results also show that the photon fluence distributions are significantly altered by adding bow tie filters. The results indicate that a combination of large cone-beam field size and large imaged target significantly increases scatter-to-primary ratios for photons that reach the detector panel. For phantoms 10 cm, 20 cm and 30 cm thick of water placed at the isocentre, the scatter-to-primary ratios are 0.94, 3.0 and 7.6 respectively for an open 125 kVp CBCT beam. The Monte Carlo simulations show that the increase of the scatter is proportional to the increase of the imaged volume, and this also applies to scatter-to-primary ratios. This study shows both the magnitude and the characteristics of scattered x-rays. The knowledge obtained from this investigation may be useful in the future design of the image detector to improve the image quality.

  6. Characteristics of kilovoltage x-ray beams used for cone-beam computed tomography in radiation therapy

    NASA Astrophysics Data System (ADS)

    Ding, George X.; Duggan, Dennis M.; Coffey, Charles W.

    2007-03-01

    The purpose of this investigation is to characterize the beams produced by a kilovoltage (kV) imager integrated into a linear accelerator (Varian on-board imager integrated into the Trilogy accelerator) for acquiring high resolution volumetric cone-beam computed tomography (CBCT) images of the patient on the treatment table. The x-ray tube is capable of generating photon spectra with kVp values between 40 and 125 kV. The Monte Carlo simulations were used to study the characteristics of kV beams and the properties of imaged target scatters. The Monte Carlo results were benchmarked against measurements, and excellent agreements were obtained. We also studied the effect of including the electron impact ionization (EII), and the simulation showed that the characteristic radiation is increased significantly in the energy spectra when EII is included. Although only slight beam hardening is observed in the spectra of all photons after passing through the phantom target, there is a significant difference in the spectra and angular distributions between scattered and primary photons. The results also show that the photon fluence distributions are significantly altered by adding bow tie filters. The results indicate that a combination of large cone-beam field size and large imaged target significantly increases scatter-to-primary ratios for photons that reach the detector panel. For phantoms 10 cm, 20 cm and 30 cm thick of water placed at the isocentre, the scatter-to-primary ratios are 0.94, 3.0 and 7.6 respectively for an open 125 kVp CBCT beam. The Monte Carlo simulations show that the increase of the scatter is proportional to the increase of the imaged volume, and this also applies to scatter-to-primary ratios. This study shows both the magnitude and the characteristics of scattered x-rays. The knowledge obtained from this investigation may be useful in the future design of the image detector to improve the image quality.

  7. Quantitative analysis of beam delivery parameters and treatment process time for proton beam therapy

    SciTech Connect

    Suzuki, Kazumichi; Gillin, Michael T.; Sahoo, Narayan; Zhu, X. Ronald; Lee, Andrew K.; Lippy, Denise

    2011-07-15

    Purpose: To evaluate patient census, equipment clinical availability, maximum daily treatment capacity, use factor for major beam delivery parameters, and treatment process time for actual treatments delivered by proton therapy systems. Methods: The authors have been recording all beam delivery parameters, including delivered dose, energy, range, spread-out Bragg peak widths, gantry angles, and couch angles for every treatment field in an electronic medical record system. We analyzed delivery system downtimes that had been recorded for every equipment failure and associated incidents. These data were used to evaluate the use factor of beam delivery parameters, the size of the patient census, and the equipment clinical availability of the facility. The duration of each treatment session from patient walk-in and to patient walk-out of the treatment room was measured for 82 patients with cancers at various sites. Results: The yearly average equipment clinical availability in the last 3 yrs (June 2007-August 2010) was 97%, which exceeded the target of 95%. Approximately 2200 patients had been treated as of August 2010. The major disease sites were genitourinary (49%), thoracic (25%), central nervous system (22%), and gastrointestinal (2%). Beams have been delivered in approximately 8300 treatment fields. The use factor for six beam delivery parameters was also evaluated. Analysis of the treatment process times indicated that approximately 80% of this time was spent for patient and equipment setup. The other 20% was spent waiting for beam delivery and beam on. The total treatment process time can be expressed by a quadratic polynomial of the number of fields per session. The maximum daily treatment capacity of our facility using the current treatment processes was estimated to be 133 {+-} 35 patients. Conclusions: This analysis shows that the facility has operated at a high performance level and has treated a large number of patients with a variety of diseases. The use

  8. SU-D-213-01: Transparent Photon Detector For The Online Monitoring Of IMRT Beams

    SciTech Connect

    Delorme, R; Arnoud, Y; Fabbro, R; Boyer, B; Rossetto, O; Gallin-Martel, L; Gallin-Martel, M; Pelissier, A; Fonteille, I

    2015-06-15

    Purpose: An innovative Transparent Detector for Radiotherapy (TraDeRa) has been developed. The detector aims at real-time monitoring of modulated beam ahead of the patient during delivery sessions, with a field cover up to 40×40 cm {sup 2}. Methods: TraDeRa consists in a pixelated matrix of ionization chambers with a patented electrodes design. An in-house designed specific integrated circuit allows to extract the signal and provides a real-time map of beam intensity and shape, at the linac pulse-scale. The measurements under irradiation are made with a 6 MV clinical X-Ray beam. Dose calculations are performed with the Monte Carlo code PENELOPE, modeling the full accelerator head and the TraDeRa detector. Results: A 2 % attenuation of the beam was measured in the presence of TraDeRa and the PENELOPE dosimetric study showed no significant modification of the photon beam properties. TraDeRa detects error leaf position as small as 1 mm compared to a reference field, for both static and modulated fields. In addition, measurements are accurate over a large dynamic range from low intensity signals, as inter-leaves leaks, to very high intensities as obtained on the medical line of the European Synchrotron Radiation Facility. The detector is fully operational for conventional and high dose rate beams as FFF modes (up to 2400 MU/min). Conclusion: The current version of TraDeRa shows promising results for IMRT quality assurance (QA), allowing pulse-scale monitoring of the beam and high sensitivity for errors detection. The attenuation is small enough not to hinder the irradiation while keeping the beam upstream of the patient under constant control. A final prototype under development will include 1600 independent electrodes, half of them with a high resolution centered on the beam axis. This compact detector provides an independent set of measurements for a better QA. Funding support : This work was supported by the LABEX PRIMES (ANR-11-LABX-0063) of Universite de Lyon

  9. Development and characterization of a three-dimensional radiochromic film stack dosimeter for megavoltage photon beam dosimetry

    SciTech Connect

    McCaw, Travis J. Micka, John A.; DeWerd, Larry A.

    2014-05-15

    Purpose: Three-dimensional (3D) dosimeters are particularly useful for verifying the commissioning of treatment planning and delivery systems, especially with the ever-increasing implementation of complex and conformal radiotherapy techniques such as volumetric modulated arc therapy. However, currently available 3D dosimeters require extensive experience to prepare and analyze, and are subject to large measurement uncertainties. This work aims to provide a more readily implementable 3D dosimeter with the development and characterization of a radiochromic film stack dosimeter for megavoltage photon beam dosimetry. Methods: A film stack dosimeter was developed using Gafchromic{sup ®} EBT2 films. The dosimeter consists of 22 films separated by 1 mm-thick spacers. A Virtual Water™ phantom was created that maintains the radial film alignment within a maximum uncertainty of 0.3 mm. The film stack dosimeter was characterized using simulations and measurements of 6 MV fields. The absorbed-dose energy dependence and orientation dependence of the film stack dosimeter were investigated using Monte Carlo simulations. The water equivalence of the dosimeter was determined by comparing percentage-depth-dose (PDD) profiles measured with the film stack dosimeter and simulated using Monte Carlo methods. Film stack dosimeter measurements were verified with thermoluminescent dosimeter (TLD) microcube measurements. The film stack dosimeter was also used to verify the delivery of an intensity-modulated radiation therapy (IMRT) procedure. Results: The absorbed-dose energy response of EBT2 film differs less than 1.5% between the calibration and film stack dosimeter geometries for a 6 MV spectrum. Over a series of beam angles ranging from normal incidence to parallel incidence, the overall variation in the response of the film stack dosimeter is within a range of 2.5%. Relative to the response to a normally incident beam, the film stack dosimeter exhibits a 1% under-response when the

  10. Experimental determination of the effective point of measurement of cylindrical ionization chambers for high-energy photon and electron beams.

    PubMed

    Huang, Yanxiao; Willomitzer, Christian; Zakaria, Golam Abu; Hartmann, Guenther H

    2010-01-01

    Measurements of depth-dose curves in water phantom using a cylindrical ionization chamber require that its effective point of measurement is located at the measuring depth. Recommendations for the position of the effective point of measurement with respect to the central axis valid for high-energy electron and photon beams are given in dosimetry protocols. According to these protocols, the use of a constant shift P(eff) is currently recommended. However, this is still based on a very limited set of experimental results. It is therefore expected that an improved knowledge of the exact position of the effective point of measurement will further improve the accuracy of dosimetry. Recent publications have revealed that the position of the effective point of measurement is indeed varying with beam energy, field size and also with chamber geometry. The aim of this study is to investigate whether the shift of P(eff) can be taken to be constant and independent from the beam energy. An experimental determination of the effective point of measurement is presented based on a comparison between cylindrical chambers and a plane-parallel chamber using conventional dosimetry equipment. For electron beams, the determination is based on the comparison of halfvalue depth R(50) between the cylindrical chamber of interest and a well guarded plane-parallel Roos chamber. For photon beams, the depth of dose maximum, d(max), the depth of 80% dose, d(80), and the dose parameter PDD(10) were used. It was again found that the effective point of measurement for both, electron and photon beams Dosimetry, depends on the beam energy. The deviation from a constant value remains very small for photons, whereas significant deviations were found for electrons. It is therefore concluded that use of a single upstream shift value from the centre of the cylindrical chamber as recommended in current dosimetry protocols is adequate for photons, however inadequate for accurate electron beam dosimetry.

  11. Watt-class high-power, high-beam-quality photonic-crystal lasers

    NASA Astrophysics Data System (ADS)

    Hirose, Kazuyoshi; Liang, Yong; Kurosaka, Yoshitaka; Watanabe, Akiyoshi; Sugiyama, Takahiro; Noda, Susumu

    2014-05-01

    The applications of surface-emitting lasers, in particular vertical-cavity surface-emitting lasers (VCSELs), are currently being extended to various low-power fields including communications and interconnections. However, the fundamental difficulties in increasing their output power by more than several milliwatts while maintaining single-mode operation prevent their application in high-power fields such as material processing, laser medicine and nonlinear optics, despite their advantageous properties of circular beams, the absence of catastrophic optical damage, and their suitability for two-dimensional integration. Here, we demonstrate watt-class high-power, single-mode operation by a two-dimensional photonic-crystal surface-emitting laser under room-temperature, continuous-wave conditions. The two-dimensional band-edge resonant effect of a photonic crystal formed by metal-organic chemical vapour deposition enables a 1,000 times broader coherent-oscillation area, which results in a high beam quality of M2 <= 1.1, narrowing the focus spot by two orders of magnitude compared to VCSELs. Our demonstration promises to realize innovative high-power applications for surface-emitting lasers.

  12. Neutron contamination of Varian Clinac iX 10 MV photon beam using Monte Carlo simulation

    NASA Astrophysics Data System (ADS)

    Yani, S.; Tursinah, R.; Rhani, M. F.; Soh, R. C. X.; Haryanto, F.; Arif, I.

    2016-03-01

    High energy medical accelerators are commonly used in radiotherapy to increase the effectiveness of treatments. As we know neutrons can be emitted from a medical accelerator if there is an incident of X-ray that hits any of its materials. This issue becomes a point of view of many researchers. The neutron contamination has caused many problems such as image resolution and radiation protection for patients and radio oncologists. This study concerns the simulation of neutron contamination emitted from Varian Clinac iX 10 MV using Monte Carlo code system. As neutron production process is very complex, Monte Carlo simulation with MCNPX code system was carried out to study this contamination. The design of this medical accelerator was modelled based on the actual materials and geometry. The maximum energy of photons and neutron in the scoring plane was 10.5 and 2.239 MeV, respectively. The number and energy of the particles produced depend on the depth and distance from beam axis. From these results, it is pointed out that the neutron produced by linac 10 MV photon beam in a typical treatment is not negligible.

  13. Monte Carlo photon beam modeling and commissioning for radiotherapy dose calculation algorithm.

    PubMed

    Toutaoui, A; Ait chikh, S; Khelassi-Toutaoui, N; Hattali, B

    2014-11-01

    The aim of the present work was a Monte Carlo verification of the Multi-grid superposition (MGS) dose calculation algorithm implemented in the CMS XiO (Elekta) treatment planning system and used to calculate the dose distribution produced by photon beams generated by the linear accelerator (linac) Siemens Primus. The BEAMnrc/DOSXYZnrc (EGSnrc package) Monte Carlo model of the linac head was used as a benchmark. In the first part of the work, the BEAMnrc was used for the commissioning of a 6 MV photon beam and to optimize the linac description to fit the experimental data. In the second part, the MGS dose distributions were compared with DOSXYZnrc using relative dose error comparison and γ-index analysis (2%/2 mm, 3%/3 mm), in different dosimetric test cases. Results show good agreement between simulated and calculated dose in homogeneous media for square and rectangular symmetric fields. The γ-index analysis confirmed that for most cases the MGS model and EGSnrc doses are within 3% or 3 mm.

  14. Two dimensional thermo-optic beam steering using a silicon photonic optical phased array

    NASA Astrophysics Data System (ADS)

    Mahon, Rita; Preussner, Marcel W.; Rabinovich, William S.; Goetz, Peter G.; Kozak, Dmitry A.; Ferraro, Mike S.; Murphy, James L.

    2016-03-01

    Components for free space optical communication terminals such as lasers, amplifiers, and receivers have all seen substantial reduction in both size and power consumption over the past several decades. However, pointing systems, such as fast steering mirrors and gimbals, have remained large, slow and power-hungry. Optical phased arrays provide a possible solution for non-mechanical beam steering devices that can be compact and lower in power. Silicon photonics is a promising technology for phased arrays because it has the potential to scale to many elements and may be compatible with CMOS technology thereby enabling batch fabrication. For most free space optical communication applications, two-dimensional beam steering is needed. To date, silicon photonic phased arrays have achieved two-dimensional steering by combining thermo-optic steering, in-plane, with wavelength tuning by means of an output grating to give angular tuning, out-of-plane. While this architecture might work for certain static communication links, it would be difficult to implement for moving platforms. Other approaches have required N2 controls for an NxN element phased array, which leads to complexity. Hence, in this work we demonstrate steering using the thermo-optic effect for both dimensions with a simplified steering mechanism requiring only two control signals, one for each steering dimension.

  15. A phantom study on the behavior of Acuros XB algorithm in flattening filter free photon beams.

    PubMed

    Muralidhar, K R; Pangam, Suresh; Srinivas, P; Athar Ali, Mirza; Priya, V Sujana; Komanduri, Krishna

    2015-01-01

    To study the behavior of Acuros XB algorithm for flattening filter free (FFF) photon beams in comparison with the anisotropic analytical algorithm (AAA) when applied to homogeneous and heterogeneous phantoms in conventional and RapidArc techniques. Acuros XB (Eclipse version 10.0, Varian Medical Systems, CA, USA) and AAA algorithms were used to calculate dose distributions for both 6X FFF and 10X FFF energies. RapidArc plans were created on Catphan phantom 504 and conventional plans on virtual homogeneous water phantom 30 × 30 × 30 cm(3), virtual heterogeneous phantom with various inserts and on solid water phantom with air cavity. Dose at various inserts with different densities were measured in both AAA and Acuros algorithms. The maximum % variation in dose was observed in (-944 HU) air insert and minimum in (85 HU) acrylic insert in both 6X FFF and 10X FFF photons. Less than 1% variation observed between -149 HU and 282 HU for both energies. At -40 HU and 765 HU Acuros behaved quite contrarily with 10X FFF. Maximum % variation in dose was observed in less HU values and minimum variation in higher HU values for both FFF energies. Global maximum dose observed at higher depths for Acuros for both energies compared with AAA. Increase in dose was observed with Acuros algorithm in almost all densities and decrease at few densities ranging from 282 to 643 HU values. Field size, depth, beam energy, and material density influenced the dose difference between two algorithms.

  16. Two-photon excitation of porphyrin-functionalized porous silicon nanoparticles for photodynamic therapy.

    PubMed

    Secret, Emilie; Maynadier, Marie; Gallud, Audrey; Chaix, Arnaud; Bouffard, Elise; Gary-Bobo, Magali; Marcotte, Nathalie; Mongin, Olivier; El Cheikh, Khaled; Hugues, Vincent; Auffan, Mélanie; Frochot, Céline; Morère, Alain; Maillard, Philippe; Blanchard-Desce, Mireille; Sailor, Michael J; Garcia, Marcel; Durand, Jean-Olivier; Cunin, Frédérique

    2014-12-03

    Porous silicon nanoparticles (pSiNPs) act as a sensitizer for the 2-photon excitation of a pendant porphyrin using NIR laser light, for imaging and photodynamic therapy. Mannose-functionalized pSiNPs can be vectorized to MCF-7 human breast cancer cells through a mannose receptor-mediated endocytosis mechanism to provide a 3-fold enhancement of the 2-photon PDT effect.

  17. Commissioning of a Varian Clinac iX 6 MV photon beam using Monte Carlo simulation

    NASA Astrophysics Data System (ADS)

    Dirgayussa, I. Gde Eka; Yani, Sitti; Rhani, M. Fahdillah; Haryanto, Freddy

    2015-09-01

    Monte Carlo modelling of a linear accelerator is the first and most important step in Monte Carlo dose calculations in radiotherapy. Monte Carlo is considered today to be the most accurate and detailed calculation method in different fields of medical physics. In this research, we developed a photon beam model for Varian Clinac iX 6 MV equipped with MilleniumMLC120 for dose calculation purposes using BEAMnrc/DOSXYZnrc Monte Carlo system based on the underlying EGSnrc particle transport code. Monte Carlo simulation for this commissioning head LINAC divided in two stages are design head Linac model using BEAMnrc, characterize this model using BEAMDP and analyze the difference between simulation and measurement data using DOSXYZnrc. In the first step, to reduce simulation time, a virtual treatment head LINAC was built in two parts (patient-dependent component and patient-independent component). The incident electron energy varied 6.1 MeV, 6.2 MeV and 6.3 MeV, 6.4 MeV, and 6.6 MeV and the FWHM (full width at half maximum) of source is 1 mm. Phase-space file from the virtual model characterized using BEAMDP. The results of MC calculations using DOSXYZnrc in water phantom are percent depth doses (PDDs) and beam profiles at depths 10 cm were compared with measurements. This process has been completed if the dose difference of measured and calculated relative depth-dose data along the central-axis and dose profile at depths 10 cm is ≤ 5%. The effect of beam width on percentage depth doses and beam profiles was studied. Results of the virtual model were in close agreement with measurements in incident energy electron 6.4 MeV. Our results showed that photon beam width could be tuned using large field beam profile at the depth of maximum dose. The Monte Carlo model developed in this study accurately represents the Varian Clinac iX with millennium MLC 120 leaf and can be used for reliable patient dose calculations. In this commissioning process, the good criteria of dose

  18. Commissioning of a Varian Clinac iX 6 MV photon beam using Monte Carlo simulation

    SciTech Connect

    Dirgayussa, I Gde Eka Yani, Sitti; Haryanto, Freddy; Rhani, M. Fahdillah

    2015-09-30

    Monte Carlo modelling of a linear accelerator is the first and most important step in Monte Carlo dose calculations in radiotherapy. Monte Carlo is considered today to be the most accurate and detailed calculation method in different fields of medical physics. In this research, we developed a photon beam model for Varian Clinac iX 6 MV equipped with MilleniumMLC120 for dose calculation purposes using BEAMnrc/DOSXYZnrc Monte Carlo system based on the underlying EGSnrc particle transport code. Monte Carlo simulation for this commissioning head LINAC divided in two stages are design head Linac model using BEAMnrc, characterize this model using BEAMDP and analyze the difference between simulation and measurement data using DOSXYZnrc. In the first step, to reduce simulation time, a virtual treatment head LINAC was built in two parts (patient-dependent component and patient-independent component). The incident electron energy varied 6.1 MeV, 6.2 MeV and 6.3 MeV, 6.4 MeV, and 6.6 MeV and the FWHM (full width at half maximum) of source is 1 mm. Phase-space file from the virtual model characterized using BEAMDP. The results of MC calculations using DOSXYZnrc in water phantom are percent depth doses (PDDs) and beam profiles at depths 10 cm were compared with measurements. This process has been completed if the dose difference of measured and calculated relative depth-dose data along the central-axis and dose profile at depths 10 cm is ≤ 5%. The effect of beam width on percentage depth doses and beam profiles was studied. Results of the virtual model were in close agreement with measurements in incident energy electron 6.4 MeV. Our results showed that photon beam width could be tuned using large field beam profile at the depth of maximum dose. The Monte Carlo model developed in this study accurately represents the Varian Clinac iX with millennium MLC 120 leaf and can be used for reliable patient dose calculations. In this commissioning process, the good

  19. Monte Carlo study of the energy and angular dependence of the response of plastic scintillation detectors in photon beams

    SciTech Connect

    Wang, Lilie L. W.; Klein, David; Beddar, A. Sam

    2010-10-15

    Purpose: By using Monte Carlo simulations, the authors investigated the energy and angular dependence of the response of plastic scintillation detectors (PSDs) in photon beams. Methods: Three PSDs were modeled in this study: A plastic scintillator (BC-400) and a scintillating fiber (BCF-12), both attached by a plastic-core optical fiber stem, and a plastic scintillator (BC-400) attached by an air-core optical fiber stem with a silica tube coated with silver. The authors then calculated, with low statistical uncertainty, the energy and angular dependences of the PSDs' responses in a water phantom. For energy dependence, the response of the detectors is calculated as the detector dose per unit water dose. The perturbation caused by the optical fiber stem connected to the PSD to guide the optical light to a photodetector was studied in simulations using different optical fiber materials. Results: For the energy dependence of the PSDs in photon beams, the PSDs with plastic-core fiber have excellent energy independence within about 0.5% at photon energies ranging from 300 keV (monoenergetic) to 18 MV (linac beam). The PSD with an air-core optical fiber with a silica tube also has good energy independence within 1% in the same photon energy range. For the angular dependence, the relative response of all the three modeled PSDs is within 2% for all the angles in a 6 MV photon beam. This is also true in a 300 keV monoenergetic photon beam for PSDs with plastic-core fiber. For the PSD with an air-core fiber with a silica tube in the 300 keV beam, the relative response varies within 1% for most of the angles, except in the case when the fiber stem is pointing right to the radiation source in which case the PSD may over-response by more than 10%. Conclusions: At {+-}1% level, no beam energy correction is necessary for the response of all three PSDs modeled in this study in the photon energy ranges from 200 keV (monoenergetic) to 18 MV (linac beam). The PSD would be even closer

  20. Photon and electron collimator effects on electron output and abutting segments in energy modulated electron therapy

    SciTech Connect

    Olofsson, Lennart; Karlsson, Magnus G.; Karlsson, Mikael

    2005-10-15

    In energy modulated electron therapy a large fraction of the segments will be arranged as abutting segments where inhomogeneities in segment matching regions must be kept as small as possible. Furthermore, the output variation between different segments should be minimized and must in all cases be well predicted. For electron therapy with add-on collimators, both the electron MLC (eMLC) and the photon MLC (xMLC) contribute to these effects when an xMLC tracking technique is utilized to reduce the x-ray induced leakage. Two add-on electron collimator geometries have been analyzed using Monte Carlo simulations: One isocentric eMLC geometry with an isocentric clearance of 35 cm and air or helium in the treatment head, and one conventional proximity geometry with a clearance of 5 cm and air in the treatment head. The electron fluence output for 22.5 MeV electrons is not significantly affected by the xMLC if the shielding margins are larger than 2-3 cm. For small field sizes and 9.6 MeV electrons, the isocentric design with helium in the treatment head or shielding margins larger than 3 cm is needed to avoid a reduced electron output. Dose inhomogeneity in the matching region of electron segments is, in general, small when collimator positions are adjusted to account for divergence in the field. The effect of xMLC tracking on the electron output can be made negligible while still obtaining a substantially reduced x-ray leakage contribution. Collimator scattering effects do not interfere significantly when abutting beam techniques are properly applied.

  1. A controllable single photon beam-splitter as a node of a quantum network

    NASA Astrophysics Data System (ADS)

    Kumar, Santosh; Gautam, Gaurav; Ghosh, Saikat; Kumar, Deepak; Indian Institute of Technology, Kanpur, India Collaboration; Jawaharlal Nehru University, New Delhi, India Collaboration

    2016-05-01

    A theoretical model for a controlled single-photon beam-splitter is proposed and analysed. It consists of two crossed optical-cavities with overlapping waists, dynamically coupled to a single flying atom. The system is shown to route a single photon with near-unity efficiency in an effective ``weak-coupling'' regime. Furthermore, two such nodes, forming a segment of a quantum network, are shown to perform several controlled quantum operations. All one-qubit operations involve a transfer of a photon from one cavity to another in a single node, while two-qubit operations involve transfer from one node to a next one, coupled via an optical fiber. Novel timing protocols for classical optical fields are found to simplify possible experimental realizations along with achievable effective parameter regime. This model can be extended to various other physical systems including gated quantum dots, circuit-QED or opto-mechanical elements. This work is supported by DST-SERB, and DAE, Government of India.

  2. Photon generator

    DOEpatents

    Srinivasan-Rao, Triveni

    2002-01-01

    A photon generator includes an electron gun for emitting an electron beam, a laser for emitting a laser beam, and an interaction ring wherein the laser beam repetitively collides with the electron beam for emitting a high energy photon beam therefrom in the exemplary form of x-rays. The interaction ring is a closed loop, sized and configured for circulating the electron beam with a period substantially equal to the period of the laser beam pulses for effecting repetitive collisions.

  3. Charged Particle Therapy with Mini-Segmented Beams

    PubMed Central

    Dilmanian, F. Avraham; Eley, John G.; Rusek, Adam; Krishnan, Sunil

    2015-01-01

    One of the fundamental attributes of proton therapy and carbon ion therapy is the ability of these charged particles to spare tissue distal to the targeted tumor. This significantly reduces normal tissue toxicity and has the potential to translate to a wider therapeutic index. Although, in general, particle therapy also reduces dose to the proximal tissues, particularly in the vicinity of the target, dose to the skin and to other very superficial tissues tends to be higher than that of megavoltage x-rays. The methods presented here, namely, “interleaved carbon minibeams” and “radiosurgery with arrays of proton and light ion minibeams,” both utilize beams segmented into arrays of parallel “minibeams” of about 0.3 mm incident-beam size. These minibeam arrays spare tissues, as demonstrated by synchrotron x-ray experiments. An additional feature of particle minibeams is their gradual broadening due to multiple Coulomb scattering as they penetrate tissues. In the case of interleaved carbon minibeams, which do not broaden much, two arrays of planar carbon minibeams that remain parallel at target depth, are aimed at the target from 90° angles and made to “interleave” at the target to produce a solid radiation field within the target. As a result, the surrounding tissues are exposed only to individual carbon minibeam arrays and are therefore spared. The method was used in four-directional geometry at the NASA Space Radiation Laboratory to ablate a 6.5-mm target in a rabbit brain at a single exposure with 40 Gy physical absorbed dose. Contrast-enhanced magnetic resonance imaging and histology 6-month later showed very focal target necrosis with nearly no damage to the surrounding brain. As for minibeams of protons and light ions, for which the minibeam broadening is substantial, measurements at MD Anderson Cancer Center in Houston, TX, USA; and Monte Carlo simulations showed that the broadening minibeams will merge with their neighbors at a certain

  4. Consequences of removing the flattening filter from linear accelerators in generating high dose rate photon beams for clinical applications: A Monte Carlo study verified by measurement

    NASA Astrophysics Data System (ADS)

    Ishmael Parsai, E.; Pearson, David; Kvale, Thomas

    2007-08-01

    An Elekta SL-25 medical linear accelerator (Elekta Oncology Systems, Crawley, UK) has been modelled using Monte Carlo simulations with the photon flattening filter removed. It is hypothesized that intensity modulated radiation therapy (IMRT) treatments may be carried out after the removal of this component despite it's criticality to standard treatments. Measurements using a scanning water phantom were also performed after the flattening filter had been removed. Both simulated and measured beam profiles showed that dose on the central axis increased, with the Monte Carlo simulations showing an increase by a factor of 2.35 for 6 MV and 4.18 for 10 MV beams. A further consequence of removing the flattening filter was the softening of the photon energy spectrum leading to a steeper reduction in dose at depths greater than the depth of maximum dose. A comparison of the points at the field edge showed that dose was reduced at these points by as much as 5.8% for larger fields. In conclusion, the greater photon fluence is expected to result in shorter treatment times, while the reduction in dose outside of the treatment field is strongly suggestive of more accurate dose delivery to the target.

  5. Direct calibration in megavoltage photon beams using Monte Carlo conversion factor: validation and clinical implications.

    PubMed

    Wright, Tracy; Lye, Jessica E; Ramanathan, Ganesan; Harty, Peter D; Oliver, Chris; Webb, David V; Butler, Duncan J

    2015-01-21

    The Australian Radiation Protection and Nuclear Safety Agency (ARPANSA) has established a method for ionisation chamber calibrations using megavoltage photon reference beams. The new method will reduce the calibration uncertainty compared to a (60)Co calibration combined with the TRS-398 energy correction factor. The calibration method employs a graphite calorimeter and a Monte Carlo (MC) conversion factor to convert the absolute dose to graphite to absorbed dose to water. EGSnrc is used to model the linac head and doses in the calorimeter and water phantom. The linac model is validated by comparing measured and modelled PDDs and profiles. The relative standard uncertainties in the calibration factors at the ARPANSA beam qualities were found to be 0.47% at 6 MV, 0.51% at 10 MV and 0.46% for the 18 MV beam. A comparison with the Bureau International des Poids et Mesures (BIPM) as part of the key comparison BIPM.RI(I)-K6 gave results of 0.9965(55), 0.9924(60) and 0.9932(59) for the 6, 10 and 18 MV beams, respectively, with all beams within 1σ of the participant average. The measured kQ values for an NE2571 Farmer chamber were found to be lower than those in TRS-398 but are consistent with published measured and modelled values. Users can expect a shift in the calibration factor at user energies of an NE2571 chamber between 0.4-1.1% across the range of calibration energies compared to the current calibration method.

  6. Dose assessment for the fetus considering scattered and secondary radiation from photon and proton therapy when treating a brain tumor of the mother

    NASA Astrophysics Data System (ADS)

    Geng, Changran; Moteabbed, Maryam; Seco, Joao; Gao, Yiming; Xu, X. George; Ramos-Méndez, José; Faddegon, Bruce; Paganetti, Harald

    2016-01-01

    The goal of this work was to determine the scattered photon dose and secondary neutron dose and resulting risk for the sensitive fetus from photon and proton radiotherapy when treating a brain tumor during pregnancy. Anthropomorphic pregnancy phantoms with three stages (3-, 6-, 9-month) based on ICRP reference parameters were implemented in Monte Carlo platform TOPAS, to evaluate the scattered dose and secondary neutron dose and dose equivalent. To evaluate the dose equivalent, dose averaged quality factors were considered for neutrons. This study compared three treatment modalities: passive scattering and pencil beam scanning proton therapy (PPT and PBS) and 6-MV 3D conformal photon therapy. The results show that, for 3D conformal photon therapy, the scattered photon dose equivalent to the fetal body increases from 0.011 to 0.030 mSv per treatment Gy with increasing stage of gestation. For PBS, the neutron dose equivalent to the fetal body was significantly lower, i.e. increasing from 1.5  ×  10-3 to 2.5  ×  10-3 mSv per treatment Gy with increasing stage of gestation. For PPT, the neutron dose equivalent of the fetus decreases from 0.17 to 0.13 mSv per treatment Gy with the growing fetus. The ratios of dose equivalents to the fetus for a 52.2 Gy(RBE) course of radiation therapy to a typical CT scan of the mother’s head ranged from 3.4-4.4 for PBS, 30-41 for 3D conformal photon therapy and 180-500 for PPT, respectively. The attained dose to a fetus from the three modalities is far lower than the thresholds of malformation, severe mental retardation and lethal death. The childhood cancer excessive absolute risk was estimated using a linear no-threshold dose-response relationship. The risk would be 1.0 (95% CI: 0.6, 1.6) and 0.1 (95% CI:  -0.01, 0.52) in 105 for the 9-month fetus for PBS with a prescribed dose of 52.2 Gy(RBE). The increased risks for PPT and photon therapy are about two and one orders of magnitude larger than that for PBS

  7. Dose assessment for the fetus considering scattered and secondary radiation from photon and proton therapy when treating a brain tumor of the mother.

    PubMed

    Geng, Changran; Moteabbed, Maryam; Seco, Joao; Gao, Yiming; Xu, X George; Ramos-Méndez, José; Faddegon, Bruce; Paganetti, Harald

    2016-01-21

    The goal of this work was to determine the scattered photon dose and secondary neutron dose and resulting risk for the sensitive fetus from photon and proton radiotherapy when treating a brain tumor during pregnancy. Anthropomorphic pregnancy phantoms with three stages (3-, 6-, 9-month) based on ICRP reference parameters were implemented in Monte Carlo platform TOPAS, to evaluate the scattered dose and secondary neutron dose and dose equivalent. To evaluate the dose equivalent, dose averaged quality factors were considered for neutrons. This study compared three treatment modalities: passive scattering and pencil beam scanning proton therapy (PPT and PBS) and 6-MV 3D conformal photon therapy. The results show that, for 3D conformal photon therapy, the scattered photon dose equivalent to the fetal body increases from 0.011 to 0.030 mSv per treatment Gy with increasing stage of gestation. For PBS, the neutron dose equivalent to the fetal body was significantly lower, i.e. increasing from 1.5 × 10(-3) to 2.5 × 10(-3) mSv per treatment Gy with increasing stage of gestation. For PPT, the neutron dose equivalent of the fetus decreases from 0.17 to 0.13 mSv per treatment Gy with the growing fetus. The ratios of dose equivalents to the fetus for a 52.2 Gy(RBE) course of radiation therapy to a typical CT scan of the mother's head ranged from 3.4-4.4 for PBS, 30-41 for 3D conformal photon therapy and 180-500 for PPT, respectively. The attained dose to a fetus from the three modalities is far lower than the thresholds of malformation, severe mental retardation and lethal death. The childhood cancer excessive absolute risk was estimated using a linear no-threshold dose-response relationship. The risk would be 1.0 (95% CI: 0.6, 1.6) and 0.1 (95% CI: -0.01, 0.52) in 10(5) for the 9-month fetus for PBS with a prescribed dose of 52.2 Gy(RBE). The increased risks for PPT and photon therapy are about two and one orders of magnitude larger than that for PBS, respectively. We can

  8. SU-E-T-637: Age and Batch Dependence of Gafchromic EBT Films in Photon and Proton Beam Dosimetry

    SciTech Connect

    Das, I; Akino, Y

    2014-06-15

    Purpose: Gafchrmoic films have undergone significant changes in characteristic over time reflected by HS, EBT, EBT2, EBT3 name. Interand intra- EBT film variability have been studied and found to be significant. However, age and lot/batch type have not been studied in various radiation beams that are investigated in this study. Methods: Thirteen sets of films; 2 EBT, 6 EBT2 and 5 EBT3 films with different lot number and expiration date were acquired. Films were cut longitudinally in 3 cm width and sandwiched between two solid water slabs that were placed in a water phantom to eliminate air gap. Each set of films were irradiated longitudinally at dmax with 6 and 15 MV photon beams as well as in reference condition (16 cm range, 10 cm SOBP) in our uniform scanning proton beam. Films were scanned using an Epson flatbed scanner (ES-10000G) after 48 hours to achieve full polymerization. The profiles were compared with the depth-dose measured with ionization chamber and net optical density (net OD) were calculated. Results: The net OD versus dose for EBT, EBT2 and EBT3 films of different age showed similar trend but with different slope. Even after calibration, differences are clearly visible in net OD in proton and photon beams. A net OD difference of nearly 0.5 is observed in photon but this was limited to 0.2–0.3 in proton beam. This relates to 20% and 15% dosimetric difference in photon and proton beam respectively over age and type of film. Conclusion: Net OD related to dose is dependent on the age and lot of the film in both photon and proton beams. It is concluded that before any set of film is used, a calibration film should be used for a meaningful dosimetry. The expired films showed larger OD variation compared to unexpired films.

  9. Partial Breast Radiation Therapy With Proton Beam: 5-Year Results With Cosmetic Outcomes

    SciTech Connect

    Bush, David A.; Do, Sharon; Lum, Sharon; Garberoglio, Carlos; Mirshahidi, Hamid; Patyal, Baldev; Grove, Roger; Slater, Jerry D.

    2014-11-01

    Purpose: We updated our previous report of a phase 2 trial using proton beam radiation therapy to deliver partial breast irradiation (PBI) in patients with early stage breast cancer. Methods and Materials: Eligible subjects had invasive nonlobular carcinoma with a maximal dimension of 3 cm. Patients underwent partial mastectomy with negative margins; axillary lymph nodes were negative on sampling. Subjects received postoperative proton beam radiation therapy to the surgical bed. The dose delivered was 40 Gy in 10 fractions, once daily over 2 weeks. Multiple fields were treated daily, and skin-sparing techniques were used. Following treatment, patients were evaluated with clinical assessments and annual mammograms to monitor toxicity, tumor recurrence, and cosmesis. Results: One hundred subjects were enrolled and treated. All patients completed the assigned treatment and were available for post-treatment analysis. The median follow-up was 60 months. Patients had a mean age of 63 years; 90% had ductal histology; the average tumor size was 1.3 cm. Actuarial data at 5 years included ipsilateral breast tumor recurrence-free survival of 97% (95% confidence interval: 100%-93%); disease-free survival of 94%; and overall survival of 95%. There were no cases of grade 3 or higher acute skin reactions, and late skin reactions included 7 cases of grade 1 telangiectasia. Patient- and physician-reported cosmesis was good to excellent in 90% of responses, was not changed from baseline measurements, and was well maintained throughout the entire 5-year follow-up period. Conclusions: Proton beam radiation therapy for PBI produced excellent ipsilateral breast recurrence-free survival with minimal toxicity. The treatment proved to be adaptable to all breast sizes and lumpectomy cavity configurations. Cosmetic results appear to be excellent and unchanged from baseline out to 5 years following treatment. Cosmetic results may be improved over those reported with photon

  10. Internal scatter, the unavoidable major component of the peripheral dose in photon-beam radiotherapy

    NASA Astrophysics Data System (ADS)

    Chofor, Ndimofor; Harder, Dietrich; Willborn, Kay C.; Poppe, Björn

    2012-03-01

    In clinical photon beams, the dose outside the geometrical field limits is produced by photons originating from (i) head leakage, (ii) scattering at the beam collimators and the flattening filter (head scatter) and (iii) scattering from the directly irradiated region of the patient or phantom (internal scatter). While the first two components can be modified, e.g. by reinforcement of shielding components or by re-modeling the filter system, internal scatter remains an unavoidable contributor to the peripheral dose. Its relative magnitude compared to the other components, its numerical variation with beam energy, field size and off-axis distance as well as its spectral distribution are evaluated in this study. We applied a detailed Monte Carlo (MC) model of our 6/15 MV Siemens Primus linear accelerator beam head, provided with ideal head leakage shielding conditions (multi-leaf collimator without gaps) to assess the head scatter contribution. Experimental values obtained under real shielding conditions were used to evaluate the head leakage contribution. It was found that the MC-computed internal scatter doses agree with the results of our previous measurements, that internal scatter is the major contributor to the peripheral dose in the near periphery while head leakage prevails in the far periphery, and that the lateral decline of the internal scatter dose can be represented by the sum of two exponentials, with an asymptotic tenth value of 18 to 19 cm. Internal scatter peripheral doses from various elementary beams are additive, so that their sum increases approximately in proportion with field size. The ratio between normalized internal scatter doses at 6 and 15 MV is approximately 2:1. The energy fluence spectra of the internal scatter component at all points of interest outside the field have peaks near 500 keV. The fact that the energy-shifted internal scatter constitutes the major contributor to the dose in the near periphery has a general bearing for

  11. Measuring linac photon beam energy through EPID image analysis of physically wedged fields

    SciTech Connect

    Dawoud, S. M. Weston, S. J.; Bond, I.; Ward, G. C.; Rixham, P. A.; Mason, J.; Huckle, A.; Sykes, J. R.

    2014-02-15

    Purpose: Electronic portal imaging devices (EPIDs) have proven to be useful tools for measuring several parameters of interest in linac quality assurance (QA). However, a method for measuring linac photon beam energy using EPIDs has not previously been reported. In this report, such a method is devised and tested, based on fitting a second order polynomial to the profiles of physically wedged beams, where the metric of interest is the second order coefficientα. The relationship between α and the beam quality index [percentage depth dose at 10 cm depth (PDD{sub 10})] is examined to produce a suitable calibration curve between these two parameters. Methods: Measurements were taken in a water-tank for beams with a range of energies representative of the local QA tolerances about the nominal value 6 MV. In each case, the beam quality was found in terms of PDD{sub 10} for 100 × 100 mm{sup 2} square fields. EPID images of 200 × 200 mm{sup 2} wedged fields were then taken for each beam and the wedge profile was fitted in MATLAB 2010b (The MathWorks, Inc., Natick, MA). α was then plotted against PDD{sub 10} and fitted with a linear relation to produce the calibration curve. The uncertainty in α was evaluated by taking five repeat EPID images of the wedged field for a beam of 6 MV nominal energy. The consistency of measuring α was found by taking repeat measurements on a single linac over a three month period. The method was also tested at 10 MV by repeating the water-tank crosscalibration for a range of energies centered approximately about a 10 MV nominal value. Finally, the calibration curve from the test linac and that from a separate clinical machine were compared to test consistency of the method across machines in a matched fleet. Results: The relationship betweenα and PDD{sub 10} was found to be strongly linear (R{sup 2} = 0.979) while the uncertainty in α was found to be negligible compared to that associated with measuring PDD{sub 10} in the water-tank (

  12. T-shaped polarization beam splitter based on two-dimensional photonic crystal waveguide structures

    NASA Astrophysics Data System (ADS)

    Li, Xinlan; Shen, Hongjun; Li, Ting; Liu, Jie; Huang, Xianjian

    2016-12-01

    A T-shaped polarization beam splitter based on two-dimensional photonic crystal is proposed, which is composed of three waveguides: one input and two output. Unpolarized beams incident from the input port will be separated into two different polarization modes and outputted individually by two different coupling structures. Simulation results can be obtained by the finite-difference time-domain (FDTD) method. In the normalized frequency range of 0.3456 < ω α /2π {}c < 0.37, multiple frequencies can obtain high transmission efficiency simultaneously for both TE and TM modes. And the degree of polarization is very closed to 1 for both output ports at this frequency range. When the normalized frequency f=0.3534 ω α /2π {}c, the transmission efficiency, respectively, is 88 % and 91 % for TE modes and TM modes. The extinction ratio is all 30dB for both modes. The polarization beam splitter attains the requirement we expected by analyzing simulation results.

  13. Synchrotron beam test of a photon counting pixel prototype based on Double-SOI technology

    NASA Astrophysics Data System (ADS)

    Zhou, Y.; Lu, Y.; Hashimoto, R.; Nishimura, R.; Kishimoto, S.; Arai, Y.; Ouyang, Q.

    2017-01-01

    The overall noise performances and first synchrotron beam measurement results of CPIXETEG3b, the first counting type Silicon-On-Insulator (SOI) pixel sensor prototype without crosstalk issue, are reported. The prototype includes a 64 × 64 pixel matrix with 50 μm pitch size. Each pixel consists of an N-in-P charge collection diode, a charge sensitive preamplifier, a shaper, a discriminator with thresholds adjustable by an in-pixel 4-bit DAC, and a 6-bit counter. The study was performed using the beam line 14A at KEK Photon Factory (KEK-PF) . The homogeneous response of the prototype, including charging-sharing effects between pixels were studied. 16 keV and 8 keV monochromatic small size (~ 10 μm diameter) X-ray beams were used for the charge sharing study, and a flat-field was added for homogenous response investigation. The overall detector homogeneity and the influence of basic detector parameters on charge sharing between pixels has been investigated.

  14. Protons, Photons, and the Prostate - Is There Emerging Evidence in the Ongoing Discussion on Particle Therapy for the Treatment of Prostate Cancer?

    PubMed

    Schiller, Kilian C; Habl, Gregor; Combs, Stephanie E

    2016-01-01

    Proton therapy is actively and repeatedly discussed within the framework of particle therapy for the treatment of prostate cancer (PC). The argument in favor of treating the prostate with protons is partly financial: given that small volumes are treated, treatment times are low, resulting in a hypothetical high patient throughput. However, such considerations should not form the basis of medical decision-making. There are also physical and biological arguments which further support the use of particle therapy for PC. The only relevant randomized data currently available is the study by Zietman and colleagues, comparing a high to a low proton boost, resulting in a significant increase in PSA-free survival in the experimental (high dose) arm (1). With modern photon treatments and image-guided radiotherapy (IGRT), equally high doses can be applied with photons and, thus, a randomized trial comparing high-end photons to protons is warranted. For high-linear energy transfer (LET) particles, such as carbon ions, the increase in relative biological effectiveness could potentially convert into an improvement in outcome. Additionally, through the physical differences of protons and carbon ions, the steeper dose gradient with carbon ions and the lack of beam broadening in the carbon beam lead to a superior dose distribution supporting the idea of hypofractionation. Biological and clinical data are emerging, however, has practice-changing evidence already arrived?

  15. Protons, Photons, and the Prostate – Is There Emerging Evidence in the Ongoing Discussion on Particle Therapy for the Treatment of Prostate Cancer?

    PubMed Central

    Schiller, Kilian C.; Habl, Gregor; Combs, Stephanie E.

    2016-01-01

    Proton therapy is actively and repeatedly discussed within the framework of particle therapy for the treatment of prostate cancer (PC). The argument in favor of treating the prostate with protons is partly financial: given that small volumes are treated, treatment times are low, resulting in a hypothetical high patient throughput. However, such considerations should not form the basis of medical decision-making. There are also physical and biological arguments which further support the use of particle therapy for PC. The only relevant randomized data currently available is the study by Zietman and colleagues, comparing a high to a low proton boost, resulting in a significant increase in PSA-free survival in the experimental (high dose) arm (1). With modern photon treatments and image-guided radiotherapy (IGRT), equally high doses can be applied with photons and, thus, a randomized trial comparing high-end photons to protons is warranted. For high-linear energy transfer (LET) particles, such as carbon ions, the increase in relative biological effectiveness could potentially convert into an improvement in outcome. Additionally, through the physical differences of protons and carbon ions, the steeper dose gradient with carbon ions and the lack of beam broadening in the carbon beam lead to a superior dose distribution supporting the idea of hypofractionation. Biological and clinical data are emerging, however, has practice-changing evidence already arrived? PMID:26858936

  16. Imaging Changes in Pediatric Intracranial Ependymoma Patients Treated With Proton Beam Radiation Therapy Compared to Intensity Modulated Radiation Therapy

    SciTech Connect

    Gunther, Jillian R.; Sato, Mariko; Chintagumpala, Murali; Ketonen, Leena; Jones, Jeremy Y.; Allen, Pamela K.; Paulino, Arnold C.; Okcu, M. Fatih; Su, Jack M.; Weinberg, Jeffrey; Boehling, Nicholas S.; Khatua, Soumen; Adesina, Adekunle; Dauser, Robert; Whitehead, William E.; Mahajan, Anita

    2015-09-01

    Purpose: The clinical significance of magnetic resonance imaging (MRI) changes after radiation therapy (RT) in children with ependymoma is not well defined. We compared imaging changes following proton beam radiation therapy (PBRT) to those after photon-based intensity modulated RT (IMRT). Methods and Materials: Seventy-two patients with nonmetastatic intracranial ependymoma who received postoperative RT (37 PBRT, 35 IMRT) were analyzed retrospectively. MRI images were reviewed by 2 neuroradiologists. Results: Sixteen PBRT patients (43%) developed postradiation MRI changes at 3.8 months (median) with resolution by 6.1 months. Six IMRT patients (17%) developed changes at 5.3 months (median) with 8.3 months to resolution. Mean age at radiation was 4.4 and 6.9 years for PBRT and IMRT, respectively (P=.06). Age at diagnosis (>3 years) and time of radiation (≥3 years) was associated with fewer imaging changes on univariate analysis (odds ratio [OR]: 0.35, P=.048; OR: 0.36, P=.05). PBRT (compared to IMRT) was associated with more frequent imaging changes, both on univariate (OR: 3.68, P=.019) and multivariate (OR: 3.89, P=.024) analyses. Seven (3 IMRT, 4 PBRT) of 22 patients with changes had symptoms requiring intervention. Most patients were treated with steroids; some PBRT patients also received bevacizumab and hyperbaric oxygen therapy. None of the IMRT patients had lasting deficits, but 2 patients died from recurrent disease. Three PBRT patients had persistent neurological deficits, and 1 child died secondarily to complications from radiation necrosis. Conclusions: Postradiation MRI changes are more common with PBRT and in patients less than 3 years of age at diagnosis and treatment. It is difficult to predict causes for development of imaging changes that progress to clinical significance. These changes are usually self-limiting, but some require medical intervention, especially those involving the brainstem.

  17. The energy dependence of the lateral dose response functions of detectors with various densities in photon-beam dosimetry

    NASA Astrophysics Data System (ADS)

    Khee Looe, Hui; Harder, Dietrich; Poppe, Björn

    2017-02-01

    The lateral dose response function is a general characteristic of the volume effect of a detector used for photon dosimetry in a water phantom. It serves as the convolution kernel transforming the true absorbed dose to water profile, which would be produced within the undisturbed water phantom, into the detector-measured signal profile. The shape of the lateral dose response function characterizes (i) the volume averaging attributable to the detector’s size and (ii) the disturbance of the secondary electron field associated with the deviation of the electron density of the detector material from the surrounding water. In previous work, the characteristic dependence of the shape of the lateral dose response function upon the electron density of the detector material was studied for 6 MV photons by Monte Carlo simulation of a wall-less voxel-sized detector (Looe et al 2015 Phys. Med. Biol. 60 6585-07). This study is here continued for 60Co gamma rays and 15 MV photons in comparison with 6 MV photons. It is found (1) that throughout these photon spectra the shapes of the lateral dose response functions are retaining their characteristic dependence on the detector’s electron density, and (2) that their energy-dependent changes are only moderate. This appears as a practical advantage because the lateral dose response function can then be treated as practically invariant across a clinical photon beam in spite of the known changes of the photon spectrum with increasing distance from the beam axis.

  18. Enhanced two-photon fluorescence imaging and therapy of cancer cells via Gold@bridged silsesquioxane nanoparticles.

    PubMed

    Croissant, Jonas; Maynadier, Marie; Mongin, Olivier; Hugues, Vincent; Blanchard-Desce, Mireille; Chaix, Arnaud; Cattoën, Xavier; Wong Chi Man, Michel; Gallud, Audrey; Gary-Bobo, Magali; Garcia, Marcel; Raehm, Laurence; Durand, Jean-Olivier

    2015-01-21

    A two-photon photosensitizer with four triethoxysilyl groups is synthesized through the click reaction. This photosensitizer allows the design of bridged silsesquioxane (BS) nanoparticles through a sol-gel process; moreover, gold core BS shells or BS nanoparticles decorated with gold nanospheres are synthesized. An enhancement of the two-photon properties is noted with gold and the nanoparticles are efficient for two-photon imaging and two-photon photodynamic therapy of cancer cells.

  19. Rationale for and Preliminary Results of Proton Beam Therapy for Mediastinal Lymphoma

    SciTech Connect

    Li Jing; Dabaja, Bouthaina; Reed, Valerie; Allen, Pamela K.; Cai, Haihong; Amin, Mayankkumar V.; Garcia, John A.; Cox, James D.

    2011-09-01

    Purpose: To evaluate the potential of three-dimensional proton beam therapy (3D-PBT) for reducing doses to normal structures in patients with mediastinal lymphomas compared with conventional photon radiation therapy (RT). Methods and Materials: We treated 10 consecutive patients with mediastinal masses from lymphomas with 3D-PBT between July 2007 and February 2009 to 30.6-50.4 cobalt-Gray equivalents (CGE). Of those patients, 7 had primary refractory or recurrent disease, and 8 had Hodgkin lymphoma. Dosimetric endpoints were compared with those from conventional RT plans. Results: PBT delivered lower mean doses to the lung (6.2 vs. 9.5 Gy), esophagus (9.5 vs. 22.3 Gy), and heart (8.8 vs. 17.7 Gy) but not the breasts (5.9 vs. 6.1 Gy) than did conventional RT. Percentages of lung, esophagus, heart, and coronary artery (particularly the left anterior descending artery) volumes receiving radiation were consistently lower in the 3D-PBT plans over a wide range of radiation doses. Of the 7 patients who had residual disease on positron emission tomography before PBT, 6 (86%) showed a complete metabolic response. Conclusions: In patients with mediastinal lymphomas, 3D-PBT produced significantly lower doses to the lung, esophagus, heart, and coronary arteries than did the current conventional RT. These lower doses would be expected to reduce the risk of late toxicities in these major organs.

  20. Intraoperative electron beam radiation therapy (IOEBRT) for carcinoma of the exocrine pancreas

    SciTech Connect

    Dobelbower, R.R. Jr.; Konski, A.A.; Merrick, H.W. III; Bronn, D.G.; Schifeling, D.; Kamen, C. )

    1991-01-01

    The abdominal cavities of 50 patients were explored in a specially constructed intraoperative radiotherapy operating amphitheater at the Medical College of Ohio. Twenty-six patients were treated with intraoperative and postoperative precision high dose external beam therapy, 12 with intraoperative irradiation but no external beam therapy, and 12 with palliative surgery alone. All but two patients completed the postoperative external beam radiation therapy as initially prescribed. The median survival time for patients treated with palliative surgery alone was 4 months, and that for patients treated with intraoperative radiotherapy without external beam therapy was 3.5 months. Patients undergoing intraoperative irradiation and external beam radiation therapy had a median survival time of 10.5 months. Four patients died within 30 days of surgery and two patients died of gastrointestinal hemorrhage 5 months posttreatment.

  1. Scatter correction for cone-beam CT in radiation therapy

    PubMed Central

    Zhu, Lei; Xie, Yaoqin; Wang, Jing; Xing, Lei

    2009-01-01

    Cone-beam CT (CBCT) is being increasingly used in modern radiation therapy for patient setup and adaptive replanning. However, due to the large volume of x-ray illumination, scatter becomes a rather serious problem and is considered as one of the fundamental limitations of CBCT image quality. Many scatter correction algorithms have been proposed in literature, while a standard practical solution still remains elusive. In radiation therapy, the same patient is scanned repetitively during a course of treatment, a natural question to ask is whether one can obtain the scatter distribution on the first day of treatment and then use the data for scatter correction in the subsequent scans on different days. To realize this scatter removal scheme, two technical pieces must be in place: (i) A strategy to obtain the scatter distribution in on-board CBCT imaging and (ii) a method to spatially match a prior scatter distribution with the on-treatment CBCT projection data for scatter subtraction. In this work, simple solutions to the two problems are provided. A partially blocked CBCT is used to extract the scatter distribution. The x-ray beam blocker has a strip pattern, such that partial volume can still be accurately reconstructed and the whole-field scatter distribution can be estimated from the detected signals in the shadow regions using interpolation∕extrapolation. In the subsequent scans, the patient transformation is determined using a rigid registration of the conventional CBCT and the prior partial CBCT. From the derived patient transformation, the measured scatter is then modified to adapt the new on-treatment patient geometry for scatter correction. The proposed method is evaluated using physical experiments on a clinical CBCT system. On the Catphan©600 phantom, the errors in Hounsfield unit (HU) in the selected regions of interest are reduced from about 350 to below 50 HU; on an anthropomorphic phantom, the error is reduced from 15.7% to 5.4%. The proposed

  2. Scatter correction for cone-beam CT in radiation therapy

    SciTech Connect

    Zhu Lei; Xie Yaoqin; Wang Jing; Xing Lei

    2009-06-15

    Cone-beam CT (CBCT) is being increasingly used in modern radiation therapy for patient setup and adaptive replanning. However, due to the large volume of x-ray illumination, scatter becomes a rather serious problem and is considered as one of the fundamental limitations of CBCT image quality. Many scatter correction algorithms have been proposed in literature, while a standard practical solution still remains elusive. In radiation therapy, the same patient is scanned repetitively during a course of treatment, a natural question to ask is whether one can obtain the scatter distribution on the first day of treatment and then use the data for scatter correction in the subsequent scans on different days. To realize this scatter removal scheme, two technical pieces must be in place: (i) A strategy to obtain the scatter distribution in on-board CBCT imaging and (ii) a method to spatially match a prior scatter distribution with the on-treatment CBCT projection data for scatter subtraction. In this work, simple solutions to the two problems are provided. A partially blocked CBCT is used to extract the scatter distribution. The x-ray beam blocker has a strip pattern, such that partial volume can still be accurately reconstructed and the whole-field scatter distribution can be estimated from the detected signals in the shadow regions using interpolation/extrapolation. In the subsequent scans, the patient transformation is determined using a rigid registration of the conventional CBCT and the prior partial CBCT. From the derived patient transformation, the measured scatter is then modified to adapt the new on-treatment patient geometry for scatter correction. The proposed method is evaluated using physical experiments on a clinical CBCT system. On the Catphan(c)600 phantom, the errors in Hounsfield unit (HU) in the selected regions of interest are reduced from about 350 to below 50 HU; on an anthropomorphic phantom, the error is reduced from 15.7% to 5.4%. The proposed method

  3. The Role of Hypofractionated Radiation Therapy with Photons, Protons, and Heavy Ions for Treating Extracranial Lesions

    PubMed Central

    Laine, Aaron Michael; Pompos, Arnold; Timmerman, Robert; Jiang, Steve; Story, Michael D.; Pistenmaa, David; Choy, Hak

    2016-01-01

    Traditionally, the ability to deliver large doses of ionizing radiation to a tumor has been limited by radiation-induced toxicity to normal surrounding tissues. This was the initial impetus for the development of conventionally fractionated radiation therapy, where large volumes of healthy tissue received radiation and were allowed the time to repair the radiation damage. However, advances in radiation delivery techniques and image guidance have allowed for more ablative doses of radiation to be delivered in a very accurate, conformal, and safe manner with shortened fractionation schemes. Hypofractionated regimens with photons have already transformed how certain tumor types are treated with radiation therapy. Additionally, hypofractionation is able to deliver a complete course of ablative radiation therapy over a shorter period of time compared to conventional fractionation regimens making treatment more convenient to the patient and potentially more cost-effective. Recently, there has been an increased interest in proton therapy because of the potential further improvement in dose distributions achievable due to their unique physical characteristics. Furthermore, with heavier ions the dose conformality is increased and, in addition, there is potentially a higher biological effectiveness compared to protons and photons. Due to the properties mentioned above, charged particle therapy has already become an attractive modality to further investigate the role of hypofractionation in the treatment of various tumors. This review will discuss the rationale and evolution of hypofractionated radiation therapy, the reported clinical success with initially photon and then charged particle modalities, and further potential implementation into treatment regimens going forward. PMID:26793619

  4. Recommendations for the referral of patients for proton-beam therapy, an Alberta Health Services report: a model for Canada?

    PubMed Central

    Patel, S.; Kostaras, X.; Parliament, M.; Olivotto, I.A.; Nordal, R.; Aronyk, K.; Hagen, N.

    2014-01-01

    Background Compared with photon therapy, proton-beam therapy (pbt) offers compelling advantages in physical dose distribution. Worldwide, gantry-based proton facilities are increasing in number, but no such facilities exist in Canada. To access pbt, Canadian patients must travel abroad for treatment at high cost. In the face of limited access, this report seeks to provide recommendations for the selection of patients most likely to benefit from pbt and suggests an out-of-country referral process. Methods The medline, embase, PubMed, and Cochrane databases were systematically searched for studies published between January 1990 and May 2014 that evaluated clinical outcomes after pbt. A draft report developed through a review of evidence was externally reviewed and then approved by the Alberta Health Services Cancer Care Proton Therapy Guidelines steering committee. Results Proton therapy is often used to treat tumours close to radiosensitive tissues and to treat children at risk of developing significant late effects of radiation therapy (rt). In uncontrolled and retrospective studies, local control rates with pbt appear similar to, or in some cases higher than, photon rt. Randomized trials comparing equivalent doses of pbt and photon rt are not available. Summary Referral for pbt is recommended for patients who are being treated with curative intent and with an expectation for long-term survival, and who are able and willing to travel abroad to a proton facility. Commonly accepted indications for referral include chordoma and chondrosarcoma, intraocular melanoma, and solid tumours in children and adolescents who have the greatest risk for long-term sequelae. Current data do not provide sufficient evidence to recommend routine referral of patients with most head-and-neck, breast, lung, gastrointestinal tract, and pelvic cancers, including prostate cancer. It is recommended that all referrals be considered by a multidisciplinary team to select appropriate cases. PMID

  5. Transmission characteristics of high-power 589-nm laser beam in photonic crystal fiber

    NASA Astrophysics Data System (ADS)

    Ito, Meguru; Hayano, Yutaka; Saito, Norihito; Akagawa, Kazuyuki; Kato, Mayumi; Saito, Yoshihiko; Takazawa, Akira; Takami, Hideki; Iye, Masanori; Wada, Satoshi; Colley, Stephen A.; Dinkins, Matthew C.; Eldred, Michael; Golota, Taras I.; Guyon, Olivier; Hattori, Masayuki; Oya, Shin; Watanabe, Makoto

    2006-06-01

    We are developing Laser Guide Star Adaptive Optics (LGSAO) system for Subaru Telescope at Hawaii, Mauna Kea. We achieved an all-solid-state 589.159 nm laser in sum-frequency generation. Output power at 589.159 nm reached 4W in quasi-continuous-wave operation. To relay the laser beam from laser location to laser launching telescope, we used an optical fiber because the optical fiber relay is more flexible and easier than mirror train. However, nonlinear scattering effect, especially stimulated Raman scattering (SRS) and stimulated Brillouin scattering (SBS), will happen when the inputted laser power increases, i.e., intensity at the fiber core exceed each threshold. In order to raise the threshold levels of each nonlinear scattering, we adopt photonic crystal fiber (PCF). Because the PCF can be made larger core than usual step index fiber (SIF), one can reduce the intensity in the core. We inputted the high power laser into the PCF whose mode field diameter (MFD) is 14 μm and the SIF whose MFD is 5 μm, and measured the transmission characteristics of them. In the case of the SIF, the SRS was happen when we inputted 2 W. On the other hand, the SRS and the SBS were not induced in the PCF even for an input power of 4 W. We also investigated polarization of the laser beam transmitting through the PCF. Because of the fact that the backscattering efficiency of exciting the sodium layer with a narrowband laser is dependent on the polarization state of the incident beam, we tried to control the polarization of the laser beam transmitted the PCF. We constructed the system which can control the polarization of input laser and measure the output polarization. The PCF showed to be able to assume as a double refraction optical device, and we found that the output polarization is controllable by injecting beam with appropriate polarization through the PCF. However, the Laser Guide Star made by the beam passed through the PCF had same brightness as the state of the polarization.

  6. A phantom study on the behavior of Acuros XB algorithm in flattening filter free photon beams

    PubMed Central

    Muralidhar, K. R.; Pangam, Suresh; Srinivas, P.; Athar Ali, Mirza; Priya, V. Sujana; Komanduri, Krishna

    2015-01-01

    To study the behavior of Acuros XB algorithm for flattening filter free (FFF) photon beams in comparison with the anisotropic analytical algorithm (AAA) when applied to homogeneous and heterogeneous phantoms in conventional and RapidArc techniques. Acuros XB (Eclipse version 10.0, Varian Medical Systems, CA, USA) and AAA algorithms were used to calculate dose distributions for both 6X FFF and 10X FFF energies. RapidArc plans were created on Catphan phantom 504 and conventional plans on virtual homogeneous water phantom 30 × 30 × 30 cm3, virtual heterogeneous phantom with various inserts and on solid water phantom with air cavity. Dose at various inserts with different densities were measured in both AAA and Acuros algorithms. The maximum % variation in dose was observed in (−944 HU) air insert and minimum in (85 HU) acrylic insert in both 6X FFF and 10X FFF photons. Less than 1% variation observed between −149 HU and 282 HU for both energies. At −40 HU and 765 HU Acuros behaved quite contrarily with 10X FFF. Maximum % variation in dose was observed in less HU values and minimum variation in higher HU values for both FFF energies. Global maximum dose observed at higher depths for Acuros for both energies compared with AAA. Increase in dose was observed with Acuros algorithm in almost all densities and decrease at few densities ranging from 282 to 643 HU values. Field size, depth, beam energy, and material density influenced the dose difference between two algorithms. PMID:26500400

  7. High speed e-beam writing for large area photonic nanostructures — a choice of parameters

    NASA Astrophysics Data System (ADS)

    Li, Kezheng; Li, Juntao; Reardon, Christopher; Schuster, Christian S.; Wang, Yue; Triggs, Graham J.; Damnik, Niklas; Müenchenberger, Jana; Wang, Xuehua; Martins, Emiliano R.; Krauss, Thomas F.

    2016-09-01

    Photonic nanostructures are used for many optical systems and applications. However, some high-end applications require the use of electron-beam lithography (EBL) to generate such nanostructures. An important technological bottleneck is the exposure time of the EBL systems, which can exceed 24 hours per 1 cm2. Here, we have developed a method based on a target function to systematically increase the writing speed of EBL. As an example, we use as the target function the fidelity of the Fourier Transform spectra of nanostructures that are designed for thin film light trapping applications, and optimize the full parameter space of the lithography process. Finally, we are able to reduce the exposure time by a factor of 5.5 without loss of photonic performance. We show that the performances of the fastest written structures are identical to the original ones within experimental error. As the target function can be varied according to different purposes, the method is also applicable to guided mode resonant grating and many other areas. These findings contribute to the advancement of EBL and point towards making the technology more attractive for commercial applications.

  8. Delivery of modulated electron beams with conventional photon multi-leaf collimators

    NASA Astrophysics Data System (ADS)

    Klein, Eric E.; Mamalui-Hunter, Maria; Low, Daniel A.

    2009-01-01

    Electron beam radiotherapy is an accepted method to treat shallow tumors. However, modulation of electrons to customize dose distributions has not readily been achieved. Studies of bolus and tertiary collimation systems have been met with limitations. We pursue the use of photon multi-leaf collimators (MLC) for modulated electron radiotherapy (MERT) to achieve customized distributions for potential clinical use. As commercial planning systems do not support the use of MLC with electrons, planning was conducted using Monte Carlo calculations. Segmented and dynamic modulated delivery of multiple electron segments was configured, calculated and delivered for validation. Delivery of electrons with segmented or dynamic leaf motion was conducted. A phantom possessing an idealized stepped target was planned and optimized with subsequent validation by measurements. Finally, clinical treatment plans were conducted for post-mastectomy and cutaneous lymphoma of the scalp using forward optimization techniques. Comparison of calculations and measurements was successful with agreement of ±2%/2 mm for the energies, segment sizes, depths tested for delivered segments for the dynamic and segmented delivery. Clinical treatment plans performed provided optimal dose coverage of the target while sparing distal organs at risk. Execution of plans using an anthropomorphic phantom to ensure safe and efficient delivery was conducted. Our study validates that MERT is not only possible using the photon MLC, but the efficient and safe delivery inherent with the dynamic delivery provides an ideal technique for shallow tumor treatment.

  9. High speed e-beam writing for large area photonic nanostructures — a choice of parameters

    PubMed Central

    Li, Kezheng; Li, Juntao; Reardon, Christopher; Schuster, Christian S.; Wang, Yue; Triggs, Graham J.; Damnik, Niklas; Müenchenberger, Jana; Wang, Xuehua; Martins, Emiliano R.; Krauss, Thomas F.

    2016-01-01

    Photonic nanostructures are used for many optical systems and applications. However, some high-end applications require the use of electron-beam lithography (EBL) to generate such nanostructures. An important technological bottleneck is the exposure time of the EBL systems, which can exceed 24 hours per 1 cm2. Here, we have developed a method based on a target function to systematically increase the writing speed of EBL. As an example, we use as the target function the fidelity of the Fourier Transform spectra of nanostructures that are designed for thin film light trapping applications, and optimize the full parameter space of the lithography process. Finally, we are able to reduce the exposure time by a factor of 5.5 without loss of photonic performance. We show that the performances of the fastest written structures are identical to the original ones within experimental error. As the target function can be varied according to different purposes, the method is also applicable to guided mode resonant grating and many other areas. These findings contribute to the advancement of EBL and point towards making the technology more attractive for commercial applications. PMID:27633902

  10. A study of the characteristics of radiation contaminants within a clinically useful photon beam.

    PubMed

    Krithivas, G; Rao, S N

    1985-01-01

    Contaminant radiation within a therapeutic beam has been studied for accelerator-produced 24-MV x rays by a direct measurement utilizing independent jaws. A carefully positioned diode was exposed to secondary radiation for various collimator settings that project field sizes between [10 X (0 + 5)] and [26 X (0 + 13)] cm at a source-to-axis distance of 1 m. [The notation [L X (W1 + W2)] means the projected field area due to lower (L) and upper (W1, W2) jaws.] Measurements were taken by placing polystyrene sheets with density thicknesses ranging from 0.21 to 4.53 g cm-2 in front of the detector. The data strongly demonstrate that with increasing field size, the ratio of the dose due to electrons to that due to photons increases rapidly. The characteristic feature of the electron depth dose curves may be linked to the observed shift in the depth of dose maximum (dmax) with field size. Data taken with a magnetic field of 0.15 T permit analysis of photons and electrons with regard to their intensity, energy, and behavior in a phantom. From an analysis of 12.5 X 12.5 cm data, various radiation components have been studied and are correlated with the observed contaminants.

  11. Carbon nanodots featuring efficient FRET for two-photon photodynamic cancer therapy with a low fs laser power density.

    PubMed

    Wang, Jing; Zhang, Zehui; Zha, Shuai; Zhu, Yinyan; Wu, Peiyi; Ehrenberg, Benjamin; Chen, Ji-Yao

    2014-11-01

    The 5,10,15,20-tetrakis(1-methyl 4-pyridinio) porphyrins (TMPyP), a photosensitizer used for photodynamic therapy of cancers (PDT), were linked to carbon dots (CDots) to form the conjugates of CDot-TMPyP by the electrostatic force. The 415 nm emission band of CDots was well overlapped with the absorption band of TMPyP, so that the Cdots in conjugates can work as donor to transfer the energy to TMPyP moiety by fluorescence resonance energy transfer (FRET) with an FRET efficiency of 45%, determined by the fluorescence lifetime change between the free CDots and conjugated CDots. The two-photon absorption cross section (TPACS) of TMPyP is as low as 110 GM and the TMPyP thus be not suitable for two-photon PDT. Whereas the CDots have high TPACS, and their TPACS are excitation wavelength dependent with the maximum value of 15000 GM at 700 nm. Therefore, the conjugates of CDot-TMPyP were explored for two-photon excitation (TPE) PDT. The two-photon image of CDot-TMPyP in Hela cells was clearly seen under the excitation of a 700 nm femto-second (fs) laser. The singlet oxygen production of CDot-TMPyP was also much higher than that of TMPyP alone under TPE of a 700 nm fs laser. The in vitro PDT killing was further achieved with CDot-TMPyP by TPE of the 700 nm fs laser. Particularly herein the low power density of fs laser from unfocused laser beam was successfully used to carry out the TPE PDT, because of the high TPACS of CDots. These results demonstrate that the CDot-TMPyP conjugates are promising for TPE PDT and needed to investigate further.

  12. Optical cone beam tomography of Cherenkov-mediated signals for fast 3D dosimetry of x-ray photon beams in water

    SciTech Connect

    Glaser, Adam K. E-mail: Brian.W.Pogue@dartmouth.edu; Andreozzi, Jacqueline M.; Zhang, Rongxiao; Pogue, Brian W. E-mail: Brian.W.Pogue@dartmouth.edu; Gladstone, David J.

    2015-07-15

    Purpose: To test the use of a three-dimensional (3D) optical cone beam computed tomography reconstruction algorithm, for estimation of the imparted 3D dose distribution from megavoltage photon beams in a water tank for quality assurance, by imaging the induced Cherenkov-excited fluorescence (CEF). Methods: An intensified charge-coupled device coupled to a standard nontelecentric camera lens was used to tomographically acquire two-dimensional (2D) projection images of CEF from a complex multileaf collimator (MLC) shaped 6 MV linear accelerator x-ray photon beam operating at a dose rate of 600 MU/min. The resulting projections were used to reconstruct the 3D CEF light distribution, a potential surrogate of imparted dose, using a Feldkamp–Davis–Kress cone beam back reconstruction algorithm. Finally, the reconstructed light distributions were compared to the expected dose values from one-dimensional diode scans, 2D film measurements, and the 3D distribution generated from the clinical Varian ECLIPSE treatment planning system using a gamma index analysis. A Monte Carlo derived correction was applied to the Cherenkov reconstructions to account for beam hardening artifacts. Results: 3D light volumes were successfully reconstructed over a 400 × 400 × 350 mm{sup 3} volume at a resolution of 1 mm. The Cherenkov reconstructions showed agreement with all comparative methods and were also able to recover both inter- and intra-MLC leaf leakage. Based upon a 3%/3 mm criterion, the experimental Cherenkov light measurements showed an 83%–99% pass fraction depending on the chosen threshold dose. Conclusions: The results from this study demonstrate the use of optical cone beam computed tomography using CEF for the profiling of the imparted dose distribution from large area megavoltage photon beams in water.

  13. Optical cone beam tomography of Cherenkov-mediated signals for fast 3D dosimetry of x-ray photon beams in water

    PubMed Central

    Glaser, Adam K.; Andreozzi, Jacqueline M.; Zhang, Rongxiao; Pogue, Brian W.; Gladstone, David J.

    2015-01-01

    Purpose: To test the use of a three-dimensional (3D) optical cone beam computed tomography reconstruction algorithm, for estimation of the imparted 3D dose distribution from megavoltage photon beams in a water tank for quality assurance, by imaging the induced Cherenkov-excited fluorescence (CEF). Methods: An intensified charge-coupled device coupled to a standard nontelecentric camera lens was used to tomographically acquire two-dimensional (2D) projection images of CEF from a complex multileaf collimator (MLC) shaped 6 MV linear accelerator x-ray photon beam operating at a dose rate of 600 MU/min. The resulting projections were used to reconstruct the 3D CEF light distribution, a potential surrogate of imparted dose, using a Feldkamp–Davis–Kress cone beam back reconstruction algorithm. Finally, the reconstructed light distributions were compared to the expected dose values from one-dimensional diode scans, 2D film measurements, and the 3D distribution generated from the clinical Varian ECLIPSE treatment planning system using a gamma index analysis. A Monte Carlo derived correction was applied to the Cherenkov reconstructions to account for beam hardening artifacts. Results: 3D light volumes were successfully reconstructed over a 400 × 400 × 350 mm3 volume at a resolution of 1 mm. The Cherenkov reconstructions showed agreement with all comparative methods and were also able to recover both inter- and intra-MLC leaf leakage. Based upon a 3%/3 mm criterion, the experimental Cherenkov light measurements showed an 83%–99% pass fraction depending on the chosen threshold dose. Conclusions: The results from this study demonstrate the use of optical cone beam computed tomography using CEF for the profiling of the imparted dose distribution from large area megavoltage photon beams in water. PMID:26133613

  14. SU-E-T-608: Perturbation Corrections for Alanine Dosimeters in Different Phantom Materials in High-Energy Photon Beams

    SciTech Connect

    Voigts-Rhetz, P von; Czarnecki, D; Anton, M; Zink, K

    2015-06-15

    Purpose: Alanine dosimeters are often used for in-vivo dosimetry purposes in radiation therapy. In a Monte Carlo study the influence of 20 different surrounding/phantom materials for alanine dosimeters was investigated. The investigations were performed in high-energy photon beams, covering the whole range from {sup 60}Co up to 25 MV-X. The aim of the study is the introduction of a perturbation correction k{sub env} for alanine dosimeters accounting for the environmental material. Methods: The influence of different surrounding materials on the response of alanine dosimeters was investigated with Monte Carlo simulations using the EGSnrc code. The photon source was adapted with BEAMnrc to a {sup 60}Co unit and an Elekta (E{sub nom}=6, 10, 25 MV-X) linear accelerator. Different tissue-equivalent materials ranging from cortical bone to lung were investigated. In addition to available phantom materials, some material compositions were taken and scaled to different electron densities. The depth of the alanine detectors within the different phantom materials corresponds to 5 cm depth in water, i.e. the depth is scaled according to the electron density (n{sub e}/n{sub e,w}) of the corresponding phantom material. The dose was scored within the detector volume once for an alanine/paraffin mixture and once for a liquid water voxel. The relative response, the ratio of the absorbed dose to alanine to the absorbed dose to water, was calculated and compared to the corresponding ratio under reference conditions. Results: For each beam quality the relative response r and the correction factor for the environment kenv was calculated. k{sub env}=0.9991+0.0049 *((n{sub e}/n{sub e,w})−0.7659){sup 3} Conclusion: A perturbation correction factor k{sub env} accounting for the phantom environment has been introduced. The response of the alanine dosimeter can be considered independent of the surrounding material for relative electron densities (n{sub e}/n{sub e,w}) between 1 and 1.4. For

  15. ``Entangled'' free-induction decay in CdS crystal under two-photon excitation by two crossed laser beams

    NASA Astrophysics Data System (ADS)

    Leontiev, A. V.; Lobkov, V. S.; Mitrofanova, T. G.; Shmelyov, A. G.; Samartsev, V. V.

    2012-09-01

    A new method of two-photon excitation of femtosecond signals of ``entangled'' free induction decay (EFID) by two crossed 790-nm laser beams in a CdS crystal at room temperature has been realized for the first time. This ``entangled'' (through the wave vectors) coherent response appears only in the case when the photons involved to the process of two-photon excitation of the sample belong to the different laser beams. This technique allows one to separate the EFID signal from the exciting femtosecond pulses and to vary the response wavelength by varying the angle between their wave vectors. The most optimal case occurs when the angle between the wave vectors of exciting pulses as well as the angle between each of these wave vectors and that of the response is equal to 60°.

  16. CONV--convolution for responses to a finite diameter photon beam incident on multi-layered tissues.

    PubMed

    Wang, L; Jacques, S L; Zheng, L

    1997-11-01

    A convolution program (CONV) solving responses to a collimated finite diameter photon beam perpendicularly incident on a multi-layered tissue has been coded in ANSI Standard C, hence, the program can be executed on various computers. The program, employing an extended trapezoidal rule for integration, convolves the responses to an infinitely narrow photon beam computed by a companion program (MCML). Dynamic data allocation is used for CONV as well as MCML, therefore, the number of tissue layers and grid elements of the grid system can be varied at run time. The potential error due to not scoring the first photon-tissue interactions separately is illustrated. The program, including the source code, has been in the public domain since 1992 and can be downloaded from the web site at http:(/)/biomed.tamu.edu/-lw.

  17. Fast Pencil Beam Dose Calculation for Proton Therapy Using a Double-Gaussian Beam Model.

    PubMed

    da Silva, Joakim; Ansorge, Richard; Jena, Rajesh

    2015-01-01

    The highly conformal dose distributions produced by scanned proton pencil beams (PBs) are more sensitive to motion and anatomical changes than those produced by conventional radiotherapy. The ability to calculate the dose in real-time as it is being delivered would enable, for example, online dose monitoring, and is therefore highly desirable. We have previously described an implementation of a PB algorithm running on graphics processing units (GPUs) intended specifically for online dose calculation. Here, we present an extension to the dose calculation engine employing a double-Gaussian beam model to better account for the low-dose halo. To the best of our knowledge, it is the first such PB algorithm for proton therapy running on a GPU. We employ two different parameterizations for the halo dose, one describing the distribution of secondary particles from nuclear interactions found in the literature and one relying on directly fitting the model to Monte Carlo simulations of PBs in water. Despite the large width of the halo contribution, we show how in either case the second Gaussian can be included while prolonging the calculation of the investigated plans by no more than 16%, or the calculation of the most time-consuming energy layers by about 25%. Furthermore, the calculation time is relatively unaffected by the parameterization used, which suggests that these results should hold also for different systems. Finally, since the implementation is based on an algorithm employed by a commercial treatment planning system, it is expected that with adequate tuning, it should be able to reproduce the halo dose from a general beam line with sufficient accuracy.

  18. System and method for delivery of neutron beams for medical therapy

    DOEpatents

    Nigg, D.W.; Wemple, C.A.

    1999-07-06

    A neutron delivery system that provides improved capability for tumor control during medical therapy is disclosed. The system creates a unique neutron beam that has a bimodal or multi-modal energy spectrum. This unique neutron beam can be used for fast-neutron therapy, boron neutron capture therapy (BNCT), or both. The invention includes both an apparatus and a method for accomplishing the purposes of the invention. 5 figs.

  19. System and method for delivery of neutron beams for medical therapy

    DOEpatents

    Nigg, David W.; Wemple, Charles A.

    1999-01-01

    A neutron delivery system that provides improved capability for tumor control during medical therapy. The system creates a unique neutron beam that has a bimodal or multi-modal energy spectrum. This unique neutron beam can be used for fast-neutron therapy, boron neutron capture therapy (BNCT), or both. The invention includes both an apparatus and a method for accomplishing the purposes of the invention.

  20. Comparison of the Effects of High-Energy Photon Beam Irradiation (10 and 18 MV) on 2 Types of Implantable Cardioverter-Defibrillators

    SciTech Connect

    Hashii, Haruko; Hashimoto, Takayuki; Okawa, Ayako; Shida, Koichi; Isobe, Tomonori; Hanmura, Masahiro; Nishimura, Tetsuo; Aonuma, Kazutaka; Sakae, Takeji; Sakurai, Hideyuki

    2013-03-01

    Purpose: Radiation therapy for cancer may be required for patients with implantable cardiac devices. However, the influence of secondary neutrons or scattered irradiation from high-energy photons (≥10 MV) on implantable cardioverter-defibrillators (ICDs) is unclear. This study was performed to examine this issue in 2 ICD models. Methods and Materials: ICDs were positioned around a water phantom under conditions simulating clinical radiation therapy. The ICDs were not irradiated directly. A control ICD was positioned 140 cm from the irradiation isocenter. Fractional irradiation was performed with 18-MV and 10-MV photon beams to give cumulative in-field doses of 600 Gy and 1600 Gy, respectively. Errors were checked after each fraction. Soft errors were defined as severe (change to safety back-up mode), moderate (memory interference, no changes in device parameters), and minor (slight memory change, undetectable by computer). Results: Hard errors were not observed. For the older ICD model, the incidences of severe, moderate, and minor soft errors at 18 MV were 0.75, 0.5, and 0.83/50 Gy at the isocenter. The corresponding data for 10 MV were 0.094, 0.063, and 0 /50 Gy. For the newer ICD model at 18 MV, these data were 0.083, 2.3, and 5.8 /50 Gy. Moderate and minor errors occurred at 18 MV in control ICDs placed 140 cm from the isocenter. The error incidences were 0, 1, and 0 /600 Gy at the isocenter for the newer model, and 0, 1, and 6 /600Gy for the older model. At 10 MV, no errors occurred in control ICDs. Conclusions: ICD errors occurred more frequently at 18 MV irradiation, which suggests that the errors were mainly caused by secondary neutrons. Soft errors of ICDs were observed with high energy photon beams, but most were not critical in the newer model. These errors may occur even when the device is far from the irradiation field.

  1. Improving the neutron-to-photon discrimination capability of detectors used for neutron dosimetry in high energy photon beam radiotherapy.

    PubMed

    Irazola, L; Terrón, J A; Bedogni, R; Pola, A; Lorenzoli, M; Sánchez-Nieto, B; Gómez, F; Sánchez-Doblado, F

    2016-09-01

    The increasing interest of the medical community to radioinduced second malignancies due to photoneutrons in patients undergoing high-energy radiotherapy, has stimulated in recent years the study of peripheral doses, including the development of some dedicated active detectors. Although these devices are designed to respond to neutrons only, their parasitic photon response is usually not identically zero and anisotropic. The impact of these facts on measurement accuracy can be important, especially in points close to the photon field-edge. A simple method to estimate the photon contribution to detector readings is to cover it with a thermal neutron absorber with reduced secondary photon emission, such as a borated rubber. This technique was applied to the TNRD (Thermal Neutron Rate Detector), recently validated for thermal neutron measurements in high-energy photon radiotherapy. The positive results, together with the accessibility of the method, encourage its application to other detectors and different clinical scenarios.

  2. Predicted Rates of Secondary Malignancies From Proton Versus Photon Radiation Therapy for Stage I Seminoma

    SciTech Connect

    Simone, Charles B.; Kramer, Kevin; O'Meara, William P.; Bekelman, Justin E.; Belard, Arnaud; McDonough, James; O'Connell, John

    2012-01-01

    Purpose: Photon radiotherapy has been the standard adjuvant treatment for stage I seminoma. Single-dose carboplatin therapy and observation have emerged as alternative options due to concerns for acute toxicities and secondary malignancies from radiation. In this institutional review board-approved study, we compared photon and proton radiotherapy for stage I seminoma and the predicted rates of excess secondary malignancies for both treatment modalities. Methods and Material: Computed tomography images from 10 consecutive patients with stage I seminoma were used to quantify dosimetric differences between photon and proton therapies. Structures reported to be at increased risk for secondary malignancies and in-field critical structures were contoured. Reported models of organ-specific radiation-induced cancer incidence rates based on organ equivalent dose were used to determine the excess absolute risk of secondary malignancies. Calculated values were compared with tumor registry reports of excess secondary malignancies among testicular cancer survivors. Results: Photon and proton plans provided comparable target volume coverage. Proton plans delivered significantly lower mean doses to all examined normal tissues, except for the kidneys. The greatest absolute reduction in mean dose was observed for the stomach (119 cGy for proton plans vs. 768 cGy for photon plans; p < 0.0001). Significantly more excess secondary cancers per 10,000 patients/year were predicted for photon radiation than for proton radiation to the stomach (4.11; 95% confidence interval [CI], 3.22-5.01), large bowel (0.81; 95% CI, 0.39-1.01), and bladder (0.03; 95% CI, 0.01-0.58), while no difference was demonstrated for radiation to the pancreas (0.02; 95% CI, -0.01-0.06). Conclusions: For patients with stage I seminoma, proton radiation therapy reduced the predicted secondary cancer risk compared with photon therapy. We predict a reduction of one additional secondary cancer for every 50 patients

  3. Evaluation of Electron Contamination in Cancer Treatment with Megavoltage Photon Beams: Monte Carlo Study

    PubMed Central

    Seif, F.; Bayatiani, M. R.

    2015-01-01

    Background Megavoltage beams used in radiotherapy are contaminated with secondary electrons. Different parts of linac head and air above patient act as a source of this contamination. This contamination can increase damage to skin and subcutaneous tissue during radiotherapy. Monte Carlo simulation is an accurate method for dose calculation in medical dosimetry and has an important role in optimization of linac head materials. The aim of this study was to calculate electron contamination of Varian linac. Materials and Method The 6MV photon beam of Varian (2100 C/D) linac was simulated by Monte Carlo code, MCNPX, based on its company’s instructions. The validation was done by comparing the calculated depth dose and profiles of simulation with dosimetry measurements in a water phantom (error less than 2%). The Percentage Depth Dose (PDDs), profiles and contamination electron energy spectrum were calculated for different therapeutic field sizes (5×5 to 40×40 cm2) for both linacs. Results The dose of electron contamination was observed to rise with increase in field size. The contribution of the secondary contamination electrons on the surface dose was 6% for 5×5 cm2 to 27% for 40×40 cm2, respectively. Conclusion Based on the results, the effect of electron contamination on patient surface dose cannot be ignored, so the knowledge of the electron contamination is important in clinical dosimetry. It must be calculated for each machine and considered in Treatment Planning Systems. PMID:25973409

  4. External audit of photon beams by mailed film dosimetry: feasibility study

    NASA Astrophysics Data System (ADS)

    Novotny, J.; Gomola, I.; Izewska, J.; Huyskens, D.; Dutreix, A.

    1997-07-01

    A feasibility study for mailed film dosimetry has been performed. The global reproducibility of the method is better than 2%. It is shown that the normalized sensitometric curve does not depend on photon beam quality in the range from Co-60 -rays to 18 MV x-rays, although the dose per optical density decreases when the energy increases. The fading of the latent image before film processing is only 3% per month and the normalized sensitometric curve is not modified after a period of 51 days between irradiation and processing. Sets of films were mailed to three different institutes for irradiation and returned for processing and evaluation after more than two months in order to verify that mailing of irradiated and unprocessed films does not produce unwanted artefacts. Finally the feasibility of external audits with mailed film dosimetry is illustrated by comparison of beam profiles measured with films and ionization chambers in a polystyrene phantom.

  5. Analysis of ionic mobilities in liquid isooctane with low dose radiotherapy pulsed photon beams

    NASA Astrophysics Data System (ADS)

    Pardo-Montero, J.; Tegami, S.; Gago-Arias, A.; González-Castaño, D. M.; Holzscheiter, M. H.; Gómez, F.

    2012-09-01

    In this work we present a model of signal temporal development in ionization chambers and we use it to determine ionic mobilities and relative densities of charge carriers in non-ultrapure liquid isooctane using a liquid-filled ionization chamber dosimeter. The detector has been irradiated with a low dose rate, short pulsed photon beam generated with a medical LINAC. Ionic mobilities have been obtained by studying the temporal development of the readout signal and fitting it to a model for low dose rate beams where recombination is negligible. The best fit has been obtained for 3 ionic species with mobilities k1 = (2.22±0.22) × 10-8, k2 = (3.37±0.43) × 10-8, k3 = (19.69±2.59) × 10-8 m2 V-1 s-1 and relative densities n1 = 0.5 (n1 is not a fitting parameter), n2 = 0.23±0.03 and n3 = 0.27±0.03.

  6. SU-E-T-359: Measurement of Various Metrics to Determine Changes in Megavoltage Photon Beam Energy

    SciTech Connect

    Gao, S; Balter, P; Rose, M; Simon, W

    2014-06-01

    Purpose: To examine the relationship between photon beam energy and various metrics for energy on the flattened and flattening filter free (FFF) beams generated by the Varian TrueBeam. Methods: Energy changes were accomplished by adjusting the bending magnet current ±10% from the nominal value for the 4, 6, 8, and 10 MV flattened and 6 and 10 MV FFF beams. Profiles were measured for a 30×30 cm{sup 2} field using a 2D ionization chamber array and a 3D water Scanner which was also used to measure PDDs. For flattened beams we compared several energy metrics; PDD at 10 cm depth in water (PDD(10)); the variation over the central 80% of the field (Flat); and the average of the highest reading along each diagonal divided by the CAX value, diagonal normalized flatness (FDN). For FFF beams we examined PDD(10), FDN, and the width of a chosen isodose level in a 30×30 cm{sup 2} field (W(d%)). Results: Changes in PDD(10) were nearly linear with changes in energy for both flattened and FFF beams as were changes in FDN. Changes in W(d%) were also nearly linear with energy for the FFF beams. PDD(10) was not as sensitive to changes in energy compared to the other metrics for either flattened or FFF beams. Flat was not as sensitive to changes in energy compared to FDN for flattened beams and its behavior depends on depth. FDN was the metric that had the highest sensitivity to the changes in energy for flattened beams while W(d%) was the metric that had highest sensitivity to the changes in energy for FFF beams. Conclusions: The metric FDN was found to be most sensitive to energy changes for flattened beams, while the W(d%) was most sensitive to energy changes for FFF beams.

  7. The effect of energy spectrum change on DNA damage in and out of field in 10-MV clinical photon beams.

    PubMed

    Ezzati, A O; Xiao, Y; Sohrabpour, M; Studenski, M T

    2015-01-01

    The aim of this study was to quantify the DNA damage induced in a clinical megavoltage photon beam at various depths in and out of the field. MCNPX was used to simulate 10 × 10 and 20 × 20 cm(2) 10-MV photon beams from a clinical linear accelerator. Photon and electron spectra were collected in a water phantom at depths of 2.5, 12.5 and 22.5 cm on the central axis and at off-axis points out to 10 cm. These spectra were used as an input to a validated microdosimetric Monte Carlo code, MCDS, to calculate the RBE of induced DSB in DNA at points in and out of the primary radiation field at three depths. There was an observable difference in the energy spectra for photons and electrons for points in the primary radiation field and those points out of field. In the out-of-field region, the mean energy for the photon and electron spectra decreased by a factor of about six and three from the in-field mean energy, respectively. Despite the differences in spectra and mean energy, the change in RBE was <1 % from the in-field region to the out-of-field region at any depth. There was no significant change in RBE regardless of the location in the phantom. Although there are differences in both the photon and electron spectra, these changes do not correlate with a change in RBE in a clinical MV photon beam as the electron spectra are dominated by electrons with energies >20 keV.

  8. An in-beam PET system for monitoring ion-beam therapy: test on phantoms using clinical 62 MeV protons

    NASA Astrophysics Data System (ADS)

    Camarlinghi, N.; Sportelli, G.; Battistoni, G.; Belcari, N.; Cecchetti, M.; Cirrone, G. A. P.; Cuttone, G.; Ferretti, S.; Kraan, A.; Retico, A.; Romano, F.; Sala, P.; Straub, K.; Tramontana, A.; Del Guerra, A.; Rosso, V.

    2014-04-01

    Ion therapy allows the delivery of highly conformal dose taking advantage of the sharp depth-dose distribution at the Bragg-peak. However, patient positioning errors and anatomical uncertainties can cause dose distortions. To exploit the full potential of ion therapy, an accurate monitoring system of the ion range is needed. Among the proposed methods to monitor the ion range, Positron Emission Tomography (PET) has proven to be the most mature technique, allowing to reconstruct the β+ activity generated in the patient by the nuclear interaction of the ions, that can be acquired during or after the treatment. Taking advantages of the spatial correlation between positron emitters created along the ions path and the dose distribution, it is possible to reconstruct the ion range. Due to the high single rates generated during the beam extraction, the acquisition of the β+ activity is typically performed after the irradiation (cyclotron) or in between the synchrotron spills. Indeed the single photon rate can be one or more orders of magnitude higher than normal for cyclotron. Therefore, acquiring the activity during the beam irradiation requires a detector with a very short dead time. In this work, the DoPET detector, capable of sustaining the high event rate generated during the cyclotron irradiation, is presented. The capability of the system to acquire data during and after the irradiation will be demonstrated by showing the reconstructed activity for different PMMA irradiations performed using clinical dose rates and the 62 MeV proton beam at the CATANA-LNS-INFN. The reconstructed activity widths will be compared with the results obtained by simulating the proton beam interaction with the FLUKA Monte Carlo. The presented data are in good agreement with the FLUKA Monte Carlo.

  9. Two-color interference effect involving three-photon atomic excitation and four-wave mixing in crossed laser beams

    SciTech Connect

    Peet, V.

    2007-09-15

    Through multiphoton ionization measurements, the polarization effects in destructive quantum interference under three-photon resonant excitation have been studied. Recent observations [V. Peet, Phys. Rev. A 74, 033406 (2006)] have indicated that contrary to the well-known pattern of a total suppression of resonance excitation, the destructive interference becomes incomplete if three-photon transition is driven by crossed beams with orthogonal polarization planes. These observations have been tested for a more general case of two-color excitation and very similar polarization-dependent anomalies in the interference character have been registered. It has been shown that the destructive interference is modified and the resonance excitation does occur if two crossed laser beams have opposite circular polarizations. The pressure-induced evolution of the uncanceled ionization peaks has the ratio of blue shift to width close to 0.5 exactly as it is known for resonance ionization peaks registered under excitation by counterpropagating laser beams.

  10. Characterization of a new commercial single crystal diamond detector for photon- and proton-beam dosimetry

    PubMed Central

    Akino, Yuichi; Gautam, Archana; Coutinho, Len; Würfel, Jan; Das, Indra J.

    2015-01-01

    A synthetic single crystal diamond detector (SCDD) is commercially available and is characterized for radiation dosimetry in various radiation beams in this study. The characteristics of the commercial SCDD model 60019 (PTW) with 6- and 15-MV photon beams, and 208-MeV proton beams, were investigated and compared with the pre-characterized detectors: Semiflex (model 31010) and PinPoint (model 31006) ionization chambers (PTW), the EDGE diode detector (Sun Nuclear Corp) and the SFD Stereotactic Dosimetry Diode Detector (IBA). To evaluate the effects of the pre-irradiation, the diamond detector, which had not been irradiated on the day, was set up in the water tank, and the response to 100 MU was measured every 20 s. The depth–dose and profiles data were collected for various field sizes and depths. For all radiation types and field sizes, the depth–dose data of the diamond chamber showed identical curves to those of the ionization chambers. The profile of the diamond detector was very similar to those of the EDGE and SFD detectors, although the Semiflex and PinPoint chambers showed volume-averaging effects in the penumbrae region. The temperature dependency was within 0.7% in the range of 4–41°C. A dose of 900 cGy and 1200 cGy was needed to stabilize the chamber to the level within 0.5% and 0.2%, respectively. The PTW type 60019 SCDD detector showed suitable characteristics for radiation dosimetry, for relative dose, depth–dose and profile measurements for a wide range of field sizes. However, at least 1000 cGy of pre-irradiation will be needed for accurate measurements. PMID:26268483

  11. A patient-specific Monte Carlo dose-calculation method for photon beams.

    PubMed

    Wang, L; Chui, C S; Lovelock, M

    1998-06-01

    A patient-specific, CT-based, Monte Carlo dose-calculation method for photon beams has been developed to correctly account for inhomogeneity in the patient. The method employs the EGS4 system to sample the interaction of radiation in the medium. CT images are used to describe the patient geometry and to determine the density and atomic number in each voxel. The user code (MCPAT) provides the data describing the incident beams, and performs geometry checking and energy scoring in patient CT images. Several variance reduction techniques have been implemented to improve the computation efficiency. The method was verified with measured data and other calculations, both in homogeneous and inhomogeneous media. The method was also applied to a lung treatment, where significant differences in dose distributions, especially in the low-density region, were observed when compared with the results using an equivalent pathlength method. Comparison of the DVHs showed that the Monte Carlo calculated plan predicted an underdose of nearly 20% to the target, while the maximum doses to the cord and the heart were increased by 25% and 33%, respectively. These results suggested that the Monte Carlo method may have an impact on treatment designs, and also that it can be used as a benchmark to assess the accuracy of other dose calculation algorithms. The computation time for the lung case employing five 15-MV wedged beams, with an approximate field size of 13 X 13 cm and the dose grid size of 0.375 cm, was less than 14 h on a 175-MHz computer with a standard deviation of 1.5% in the high-dose region.

  12. Simultaneous two-photon activation of type-I photodynamic therapy agents.

    PubMed

    Fisher, W G; Partridge, W P; Dees, C; Wachter, E A

    1997-08-01

    The excitation and emission properties of several psoralen derivatives are compared using conventional single-photon excitation and simultaneous two-photon excitation (TPE). Two-photon excitation is effected using the output of a mode-locked titanium: sapphire laser, the near infrared output of which is used to promote nonresonant TPE directly. Specifically, the excitation spectra and excited-state properties of 8-methoxypsoralen and 4'-aminomethyl-4,5,8-trimethylpsoralen are shown to be equivalent using both modes of excitation. Further, in vitro feasibility of two-photon photodynamic therapy (PDT) is demonstrated using Salmonella typhimurium. Two-photon excitation may be beneficial in the practice of PDT because it would allow replacement of visible or UV excitation light with highly penetrating, nondamaging near infrared light and could provide a means for improving localization of therapy. Comparison of possible laser excitation sources for PDT reveals the titanium: sapphire laser to be exceptionally well suited for nonlinear excitation of PDT agents in biological systems due to its extremely short pulse width and high repetition rate that together provide efficient PDT activation and greatly reduced potential for biological damage.

  13. Reference photon dosimetry data and reference phase space data for the 6 MV photon beam from Varian Clinac 2100 series linear accelerators

    SciTech Connect

    Cho, Sang Hyun; Vassiliev, Oleg N.; Lee, Seungsoo; Liu, H. Helen; Ibbott, Geoffrey S.; Mohan, Radhe

    2005-01-01

    The current study presents the reference photon dosimetry data (RPDD) and reference phase space data (RPSD) for the 6 MV photon beam from Varian 2100 series linear accelerators. The RPDD provide the basic photon dosimetry data, typically collected during the initial commissioning of a new linear accelerator, including output factors, depth dose data, and beam profile data in air and in water. The RPSD provide the full phase space information, such as position, direction, and energy for each particle generated inside the head of any particular linear accelerator in question. The dosimetric characteristics of the 6 MV photon beam from the majority of the aforementioned accelerators, which are unaltered from the manufacturer's original specifications, can be fully described with these two data sets within a clinically acceptable uncertainty ({approx}{+-}2%). The current study also presents a detailed procedure to establish the RPDD and RPSD using measured data and Monte Carlo calculations. The RPDD were constructed by compiling our own measured data and the average data based on the analysis of more than 50 sets of measured data from the Radiological Physics Center (RPC) and 10 sets of clinical dosimetry data obtained from 10 different institutions participating in the RPC's quality assurance monitoring program. All the measured data from the RPC and the RPC-monitored institutions were found to be within a statistically tight range (i.e., 1{sigma}{approx_equal}1% or less) for each dosimetric quantity. The manufacturer's standard data, except for in-air off-axis factors that are available only from the current study, were compared with the RPDD, showing that the manufacturer's standard data could also be used as the RPDD for the photon beam studied in this study. The RPSD were obtained from Monte Carlo calculations using the BEAMnrc/DOSXYZnrc code system with 6.2 MeV (a spread of 3% full width at half maximum) and 1.0 mm full width at half maximum as the values of the

  14. The Evolution of External Beam Radiation Therapy (EBRT) from a Technological Perspective.

    NASA Astrophysics Data System (ADS)

    Detorie, Nicholas

    2008-03-01

    Since the discovery of x-rays by Roentgen in 1895 ionizing radiations have been used as a treatment for cancer. Such treatments have been based on either implantation of radioactive materials at the site of disease or by aiming external radiation beams at the diseased site. This later method is referred to as teletherapy because the beams originate from a location outside of the body distant from the disease site itself. A brief review of the basic radiation biology will be given to illustrate the rationale for therapeutic use of ionizing radiations and the effects of beam energy and beam type- particulate or photon. The remainder of the presentation will focus on the technological teletherapy developments supported by the required physical properties of the beams and their associated characteristics that make them suitable for patient treatments. Chronological highlights will include the following sources or devices: superficial x-rays, orthovaltage x-rays, megavoltage x-rays and Cobalt 60 photons, electron beams, neutron beams, negative pi mesons, protons, and heavy ions. The presentation will illustrate how the physical beam properties have been incorporated into modern radiation treatment devices, many of which are equipped with radiation imaging capability. Such devices include: linacs equipped with multileaf collimators for beam shaping and intensity modulation, the Gamma Knife for precise and accurate irradiation of brain tumors or arterial-venous malformations (AVM), the robotic arm based Cyber Knife, and the Helical Tomotherapy unit.

  15. Optimal energy for cell radiosensitivity enhancement by gold nanoparticles using synchrotron-based monoenergetic photon beams.

    PubMed

    Rahman, Wan Nordiana; Corde, Stéphanie; Yagi, Naoto; Abdul Aziz, Siti Aishah; Annabell, Nathan; Geso, Moshi

    2014-01-01

    Gold nanoparticles have been shown to enhance radiation doses delivered to biological targets due to the high absorption coefficient of gold atoms, stemming from their high atomic number (Z) and physical density. These properties significantly increase the likelihood of photoelectric effects and Compton scattering interactions. Gold nanoparticles are a novel radiosensitizing agent that can potentially be used to increase the effectiveness of current radiation therapy techniques and improve the diagnosis and treatment of cancer. However, the optimum radiosensitization effect of gold nanoparticles is strongly dependent on photon energy, which theoretically is predicted to occur in the kilovoltage range of energy. In this research, synchrotron-generated monoenergetic X-rays in the 30-100 keV range were used to investigate the energy dependence of radiosensitization by gold nanoparticles and also to determine the photon energy that produces optimum effects. This investigation was conducted using cells in culture to measure dose enhancement. Bovine aortic endothelial cells with and without gold nanoparticles were irradiated with X-rays at energies of 30, 40, 50, 60, 70, 81, and 100 keV. Trypan blue exclusion assays were performed after irradiation to determine cell viability. Cell radiosensitivity enhancement was indicated by the dose enhancement factor which was found to be maximum at 40 keV with a value of 3.47. The dose enhancement factor obtained at other energy levels followed the same direction as the theoretical calculations based on the ratio of the mass energy absorption coefficients of gold and water. This experimental evidence shows that the radiosensitization effect of gold nanoparticles varies with photon energy as predicted from theoretical calculations. However, prediction based on theoretical assumptions is sometimes difficult due to the complexity of biological systems, so further study at the cellular level is required to fully characterize the effects

  16. Quantification of beam complexity in intensity-modulated radiation therapy treatment plans

    SciTech Connect

    Du, Weiliang Cho, Sang Hyun; Zhang, Xiaodong; Kudchadker, Rajat J.; Hoffman, Karen E.

    2014-02-15

    Purpose: Excessive complexity in intensity-modulated radiation therapy (IMRT) plans increases the dose uncertainty, prolongs the treatment time, and increases the susceptibility to changes in patient or target geometry. To date, the tools for quantitative assessment of IMRT beam complexity are still lacking. In this study, The authors have sought to develop metrics to characterize different aspects of beam complexity and investigate the beam complexity for IMRT plans of different disease sites. Methods: The authors evaluated the beam complexity scores for 65 step-and-shoot IMRT plans from three sites (prostate, head and neck, and spine) and 26 volumetric-modulated arc therapy (VMAT) plans for the prostate. On the basis of the beam apertures and monitor unit weights of all segments, the authors calculated the mean aperture area, extent of aperture shape irregularity, and degree of beam modulation for each beam. Then the beam complexity values were averaged to obtain the complexity metrics of the IMRT plans. The authors studied the correlation between the beam complexity metrics and the quality assurance (QA) results. Finally, the effects of treatment planning parameters on beam complexity were studied. Results: The beam complexity scores were not uniform among the prostate IMRT beams from different gantry angles. The lateral beams had larger monitor units and smaller shape irregularity, while the anterior-posterior beams had larger modulation values. On average, the prostate IMRT plans had the smallest aperture irregularity, beam modulation, and normalized monitor units; the head and neck IMRT plans had large beam irregularity and beam modulation; and the spine stereotactic radiation therapy plans often had small beam apertures, which may have been associated with the relatively large discrepancies between planned and QA measured doses. There were weak correlations between the beam complexity scores and the measured dose errors. The prostate VMAT beams showed

  17. Nanodosimetric measurements and calculations in a neutron therapy beam.

    PubMed

    Grindborg, J-E; Lillhök, J E; Lindborg, L; Gudowska, I; Söderberg, J; Carlsson, G Alm; Nikjoo, H

    2007-01-01

    A comparison of calculated and measured values of the dose mean lineal energy (y(D)) for the former neutron therapy beam at Louvain-la-Neuve is reported. The measurements were made with wall-less tissue-equivalent proportional counters using the variance-covariance method and simulating spheres with diameters between 10 nm and 15 microm. The calculated y(D)-values were obtained from simulated energy distributions of neutrons and charged particles inside an A-150 phantom and from published y(D)-values for mono-energetic ions. The energy distributions of charged particles up to oxygen were determined with the SHIELD-HIT code using an MCNPX simulated neutron spectrum as an input. The mono-energetic ion y(D)-values in the range 3-100 nm were taken from track-structure simulations in water vapour done with PITS/KURBUC. The large influence on the dose mean lineal energy from the light ion (A > 4) absorbed dose fraction, may explain an observed difference between experiment and calculation. The latter being larger than earlier reported result. Below 50 nm, the experimental values increase while the calculated decrease.

  18. 3D printed plastics for beam modulation in proton therapy.

    PubMed

    Lindsay, C; Kumlin, J; Jirasek, A; Lee, R; Martinez, D M; Schaffer, P; Hoehr, C

    2015-06-07

    Two 3D printing methods, fused filament fabrication (FFF) and PolyJet™ (PJ) were investigated for suitability in clinical proton therapy (PT) energy modulation. Measurements of printing precision, printed density and mean stopping power are presented. FFF is found to be accurate to 0.1 mm, to contain a void fraction of 13% due to air pockets and to have a mean stopping power dependent on geometry. PJ was found to print accurate to 0.05 mm, with a material density and mean stopping power consistent with solid poly(methyl methacrylate) (PMMA). Both FFF and PJ were found to print significant, sporadic defects associated with sharp edges on the order of 0.2 mm. Site standard PT modulator wheels were printed using both methods. Measured depth-dose profiles with a 74 MeV beam show poor agreement between PMMA and printed FFF wheels. PJ printed wheel depth-dose agreed with PMMA within 1% of treatment dose except for a distal falloff discrepancy of 0.5 mm.

  19. 3D printed plastics for beam modulation in proton therapy

    NASA Astrophysics Data System (ADS)

    Lindsay, C.; Kumlin, J.; Jirasek, A.; Lee, R.; Martinez, D. M.; Schaffer, P.; Hoehr, C.

    2015-06-01

    Two 3D printing methods, fused filament fabrication (FFF) and PolyJet™ (PJ) were investigated for suitability in clinical proton therapy (PT) energy modulation. Measurements of printing precision, printed density and mean stopping power are presented. FFF is found to be accurate to 0.1 mm, to contain a void fraction of 13% due to air pockets and to have a mean stopping power dependent on geometry. PJ was found to print accurate to 0.05 mm, with a material density and mean stopping power consistent with solid poly(methyl methacrylate) (PMMA). Both FFF and PJ were found to print significant, sporadic defects associated with sharp edges on the order of 0.2 mm. Site standard PT modulator wheels were printed using both methods. Measured depth-dose profiles with a 74 MeV beam show poor agreement between PMMA and printed FFF wheels. PJ printed wheel depth-dose agreed with PMMA within 1% of treatment dose except for a distal falloff discrepancy of 0.5 mm.

  20. Proton Beam Therapy Interference With Implanted Cardiac Pacemakers

    SciTech Connect

    Oshiro, Yoshiko Sugahara, Shinji; Noma, Mio; Sato, Masato; Sakakibara, Yuzuru; Sakae, Takeji; Hayashi, Yasutaka; Nakayama, Hidetsugu; Tsuboi, Koji; Fukumitsu, Nobuyoshi; Kanemoto, Ayae; Hashimoto, Takayuki; Tokuuye, Koichi

    2008-11-01

    Purpose: To investigate the effect of proton beam therapy (PBT) on implanted cardiac pacemaker function. Methods and Materials: After a phantom study confirmed the safety of PBT in patients with cardiac pacemakers, we treated 8 patients with implanted pacemakers using PBT to a total tumor dose of 33-77 gray equivalents (GyE) in dose fractions of 2.2-6.6 GyE. The combined total number of PBT sessions was 127. Although all pulse generators remained outside the treatment field, 4 patients had pacing leads in the radiation field. All patients were monitored by means of electrocardiogram during treatment, and pacemakers were routinely examined before and after PBT. Results: The phantom study showed no effect of neutron scatter on pacemaker generators. In the study, changes in heart rate occurred three times (2.4%) in 2 patients. However, these patients remained completely asymptomatic throughout the PBT course. Conclusions: PBT can result in pacemaker malfunctions that manifest as changes in pulse rate and pulse patterns. Therefore, patients with cardiac pacemakers should be monitored by means of electrocardiogram during PBT.

  1. Characterization of rare-earth-doped nanophosphors for photodynamic therapy excited by clinical ionizing radiation beams

    NASA Astrophysics Data System (ADS)

    Darafsheh, Arash; Najmr, Stan; Paik, Taejong; Tenuto, Michael E.; Murray, Christopher B.; Finlay, Jarod C.; Friedberg, Joseph S.

    2015-03-01

    We investigated the optical properties of novel terbium (Tb3+)-doped nanophosphors with various host compounds irradiated by clinical electron, photon, and proton beams for their potential as optical probes. The emission spectra of nanophosphors embedded in tissue-mimicking phantoms were collected by an optical fiber connected to a CCD-coupled spectrograph while the samples were irradiated with electron and photon beams generated by a medical linear accelerator and proton beams generated by a clinical cyclotron. We characterized the luminescence of such nanophosphors as a function of the beam energy and observed a dose dependency of the luminescence signal. We demonstrated x-ray luminescence, cathodoluminescence, and ionoluminescence of the nanophosphors in clinical ionizing radiation fields, which indicates their potential as downconverters of high-energy radiation into visible light.

  2. Wave-mixing interference in three-photon resonant atomic excitation with cross-polarized angled beams

    SciTech Connect

    Peet, V.

    2006-09-15

    Three-photon excitation and associated wave mixing near the 6s and 6s{sup '} resonances of xenon have been studied utilizing resonance-enhanced multiphoton ionization in angled beams with different polarizations. It has been shown that a complete cancellation of three-photon resonant atomic excitation caused by the well-known destructive wave-mixing interference occurs in s and p polarization of angled beams but distinct resonance ionization enhancement is observed when pump beams have orthogonal polarization planes. Pressure-induced evolution of the resonance ionization peak in cross-polarized beams is identical to that observed with counterpropagating beams. The reason for such resonance ionization enhancement is unknown and cannot be explained within the frame work of existing theory. The effect may result from some peculiarities of wave-mixing interference in a multilevel atomic system, where different degenerate magnetic sublevels of the upper atomic state and multiple interfering excitation processes are involved. Another possibility is that the resonance ionization enhancement results from a process where weak counterpropagating light is generated within the excitation region of cross-polarized angled beams.

  3. A virtual source model of electron contamination of a therapeutic photon beam.

    PubMed

    Sikora, M; Alber, M

    2009-12-21

    The most efficient way of generating particles for Monte Carlo (MC) dose calculation is through a virtual source model (VSM) of the linear accelerator head. We have previously developed a VSM based on three sources: a primary photon source, a secondary photon source and an electron contamination source (Sikora et al 2007). In this work, we present an improvement of the electron contamination source. The VSM of contamination electrons (eVSM) is derived from a full MC simulation of the accelerator head with the BEAMnrc MC system. It comprises a Gaussian source located at the base of the flattening filter. The eVSM models two effects: an energy-dependent source diameter and an angular dependence of the particle fluence. The air scatter of the contamination electrons is approximated by energetic properties of the eVSM so that explicit in-air transport is not required during MC simulation of the dose distributions in the patient. The calculations of electron dose distributions were compared between the eVSM and the full MC simulation. Good agreement was achieved for various rectangular field sizes as well as for complex conformal segment shapes for the contamination electrons of 6 and 15 MV beams. The 3D dose evaluation of the surface dose in a CT-based patient geometry shows high accuracy (2%/2 mm) of the eVSM for both energies. The model has one tunable parameter, the mean energy of the spectrum at the patient surface. High accuracy and efficiency of particle generation make the eVSM a valuable virtual source of contamination electrons for MC treatment planning systems.

  4. Low-energy broad-beam photon shielding data for constituents of concrete.

    PubMed

    Ogundare, Folorunso O; Ogundele, Samuel A; Akerele, Olumide O; Balogun, Fatai A

    2012-03-08

    The ability of concrete to attenuate ionizing radiation intensity is assessed using its linear or mass attenuation coefficient. In this work, the broad-beam linear and mass attenuation coefficients of different types of soils and cements used for making concrete were measured at different photon energies (60-1333 keV), nearly spanning the diagnostic photon energy range, using a NaI detector. The mass attenuation coefficients of cement decreased from 0.133 ± 0.002 at 60 keV to 0.047 ± 0.003 at 1332.5 keV. For soils, the mass attenuation coefficient of those collected from the beach was the highest, decreasing from 0.176 ± 0.003 cm²/g at 60 keV to 0.054 ± 0.001 cm²/g at 1332.5 keV. Land soils had the least value, decreasing from 0.124 ± 0.002 cm²/g at 60 keV to 0.044 ± 0.003 cm²/g at 1332.5 keV. Limestone had smaller mass attenuation coefficients than the cement produced using it. The implication of the above is that for making concrete, beach sand should be preferred as the sand component of the concrete. Models of the form μ(L) = A(E) exp[B(E)ρ] and μ(m) = αln(E)+β are proposed for fitting the linear attenuation coefficient and mass attenuation coefficient data, respectively.

  5. Proton Beam Therapy and Concurrent Chemotherapy for Esophageal Cancer

    SciTech Connect

    Lin, Steven H.; Komaki, Ritsuko; Liao Zhongxing; Wei, Caimiao; Myles, Bevan; Guo Xiaomao; Palmer, Matthew; Mohan, Radhe; Swisher, Stephen G.; Hofstetter, Wayne L.; Ajani, Jaffer A.; Cox, James D.

    2012-07-01

    Purpose: Proton beam therapy (PBT) is a promising modality for the management of thoracic malignancies. We report our preliminary experience of treating esophageal cancer patients with concurrent chemotherapy (CChT) and PBT (CChT/PBT) at MD Anderson Cancer Center. Methods and Materials: This is an analysis of 62 esophageal cancer patients enrolled on a prospective study evaluating normal tissue toxicity from CChT/PBT from 2006 to 2010. Patients were treated with passive scattering PBT with two- or three-field beam arrangement using 180 to 250 MV protons. We used the Kaplan-Meier method to assess time-to-event outcomes and compared the distributions between groups using the log-rank test. Results: The median follow-up time was 20.1 months for survivors. The median age was 68 years (range, 38-86). Most patients were males (82%) who had adenocarcinomas (76%) and Stage II-III disease (84%). The median radiation dose was 50.4 Gy (RBE [relative biologic equivalence]) (range, 36-57.6). The most common grade 2 to 3 acute toxicities from CChT/PBT were esophagitis (46.8%), fatigue (43.6%), nausea (33.9%), anorexia (30.1%), and radiation dermatitis (16.1%). There were two cases of grade 2 and 3 radiation pneumonitis and two cases of grade 5 toxicities. A total of 29 patients (46.8%) received preoperative CChT/PBT, with one postoperative death. The pathologic complete response (pCR) rate for the surgical cohort was 28%, and the pCR and near CR rates (0%-1% residual cells) were 50%. While there were significantly fewer local-regional recurrences in the preoperative group (3/29) than in the definitive CChT/PBT group (16/33) (log-rank test, p = 0.005), there were no differences in distant metastatic (DM)-free interval or overall survival (OS) between the two groups. Conclusions: This is the first report of patients treated with PBT/CChT for esophageal cancer. Our data suggest that this modality is associated with a few severe toxicities, but the pathologic response and clinical

  6. Comparison of intensity modulated radiotherapy (IMRT) with intensity modulated particle therapy (IMPT) using fixed beams or an ion gantry for the treatment of patients with skull base meningiomas

    PubMed Central

    2012-01-01

    Background To examine the potential improvement in treatment planning for patients with skull base meningioma using IMRT compared to carbon ion or proton beams with and without a gantry. Methods Five patients originally treated with photon IMRT were selected for the study. Ion beams were chosen using a horizontal beam or an ion gantry. Intensity controlled raster scanning and the intensity modulated particle therapy mode were used for plan optimization. The evaluation included analysis of dose-volume histograms of the target volumes and organs at risk. Results In comparison with carbon and proton beams only with horizontal beams, carbon ion treatment plans could spare the OARs more and concentrated on the target volumes more than proton and photon IMRT treatment plans. Using only a horizontal fixed beam, satisfactory plans could be achieved for skull base tumors. Conclusion The results of the case studies showed that using IMPT has the potential to overcome the lack of a gantry for skull base tumors. Carbon ion plans offered slightly better dose distributions than proton plans, but the differences were not clinically significant with established dose prescription concepts. PMID:22439607

  7. Adjustment procedure for beam alignment in scanned ion-beam therapy

    NASA Astrophysics Data System (ADS)

    Saraya, Y.; Takeshita, E.; Furukawa, T.; Hara, Y.; Mizushima, K.; Saotome, N.; Tansho, R.; Shirai, T.; Noda, K.

    2016-09-01

    Control of the beam position for three-dimensional pencil-beam scanning is important because the position accuracy of the beam significantly impacts the alignment of the irradiation field. To suppress this effect, we have developed a simple procedure for beamline tuning. At first, beamline tuning is performed with steering magnets and fluorescent screen monitors to converge the beam's trajectory to a central orbit. Misalignment between the beam's position and the reference axis is checked by using the verification system, which consists of a screen monitor and an acrylic phantom. If the beam position deviates from the reference axis, two pairs of steering magnets, which are placed on downstream of the beam transport line, will be corrected. These adjustments are iterated until the deviations for eleven energies of the beam are within 0.5 mm of the reference axis. To demonstrate the success of our procedure, we used our procedure to perform beam commissioning at the Kanagawa Cancer Center.

  8. Optimization of beam quality for photon-counting spectral computed tomography in head imaging: simulation study

    PubMed Central

    Chen, Han; Xu, Cheng; Persson, Mats; Danielsson, Mats

    2015-01-01

    Abstract. Head computed tomography (CT) plays an important role in the comprehensive evaluation of acute stroke. Photon-counting spectral detectors, as promising candidates for use in the next generation of x-ray CT systems, allow for assigning more weight to low-energy x-rays that generally contain more contrast information. Most importantly, the spectral information can be utilized to decompose the original set of energy-selective images into several basis function images that are inherently free of beam-hardening artifacts, a potential advantage for further improving the diagnosis accuracy. We are developing a photon-counting spectral detector for CT applications. The purpose of this work is to determine the optimal beam quality for material decomposition in two head imaging cases: nonenhanced imaging and K-edge imaging. A cylindrical brain tissue of 16-cm diameter, coated by a 6-mm-thick bone layer and 2-mm-thick skin layer, was used as a head phantom. The imaging target was a 5-mm-thick blood vessel centered in the head phantom. In K-edge imaging, two contrast agents, iodine and gadolinium, with the same concentration (5  mg/mL) were studied. Three parameters that affect beam quality were evaluated: kVp settings (50 to 130 kVp), filter materials (Z=13 to 83), and filter thicknesses [0 to 2 half-value layer (HVL)]. The image qualities resulting from the varying x-ray beams were compared in terms of two figures of merit (FOMs): squared signal-difference-to-noise ratio normalized by brain dose (SDNR2/BD) and that normalized by skin dose (SDNR2/SD). For nonenhanced imaging, the results show that the use of the 120-kVp spectrum filtered by 2 HVL copper (Z=29) provides the best performance in both FOMs. When iodine is used in K-edge imaging, the optimal filter is 2 HVL iodine (Z=53) and the optimal kVps are 60 kVp in terms of SDNR2/BD and 75 kVp in terms of SDNR2/SD. A tradeoff of 65 kVp was proposed to lower the potential risk of skin injuries if a

  9. Effects of electron beam parameters and velocity spread on radio frequency output of a photonic band gap cavity gyrotron oscillator

    NASA Astrophysics Data System (ADS)

    Singh, Ashutosh; Jain, P. K.

    2015-09-01

    In this paper, the effects of electron beam parameters and velocity spread on the RF behavior of a metallic photonic band gap (PBG) cavity gyrotron operating at 35 GHz with TE041-like mode have been theoretically demonstrated. PBG cavity is used here to achieve a single mode operation of the overmoded cavity. The nonlinear time-dependent multimode analysis has been used to observe the beam-wave interaction behavior of the PBG cavity gyrotron, and a commercially available PIC code "CST Particle Studio" has been reconfigured to obtain 3D simulation results in order to validate the analytical values. The output power for this typical PBG gyrotron has been obtained ˜108 kW with ˜15.5% efficiency in a well confined TE041-like mode, while all other competing modes have significantly low values of power output. The output power and efficiency of a gyrotron depend highly on the electron beam parameters and velocity spread. The influence of several electron beam parameters, e.g., beam voltage, beam current, beam velocity pitch factor, and DC magnetic field, on the PBG gyrotron operations has been investigated. This study would be helpful in optimising the electron beam parameters and estimating accurate RF output power of the high frequency PBG cavity based gyrotron oscillators.

  10. Effects of electron beam parameters and velocity spread on radio frequency output of a photonic band gap cavity gyrotron oscillator

    SciTech Connect

    Singh, Ashutosh; Jain, P. K.

    2015-09-15

    In this paper, the effects of electron beam parameters and velocity spread on the RF behavior of a metallic photonic band gap (PBG) cavity gyrotron operating at 35 GHz with TE{sub 041}–like mode have been theoretically demonstrated. PBG cavity is used here to achieve a single mode operation of the overmoded cavity. The nonlinear time-dependent multimode analysis has been used to observe the beam-wave interaction behavior of the PBG cavity gyrotron, and a commercially available PIC code “CST Particle Studio” has been reconfigured to obtain 3D simulation results in order to validate the analytical values. The output power for this typical PBG gyrotron has been obtained ∼108 kW with ∼15.5% efficiency in a well confined TE{sub 041}–like mode, while all other competing modes have significantly low values of power output. The output power and efficiency of a gyrotron depend highly on the electron beam parameters and velocity spread. The influence of several electron beam parameters, e.g., beam voltage, beam current, beam velocity pitch factor, and DC magnetic field, on the PBG gyrotron operations has been investigated. This study would be helpful in optimising the electron beam parameters and estimating accurate RF output power of the high frequency PBG cavity based gyrotron oscillators.

  11. Malfunctions of Implantable Cardiac Devices in Patients Receiving Proton Beam Therapy: Incidence and Predictors

    SciTech Connect

    Gomez, Daniel R.; Poenisch, Falk; Pinnix, Chelsea C.; Sheu, Tommy; Chang, Joe Y.; Memon, Nada; Mohan, Radhe; Rozner, Marc A.; Dougherty, Anne H.

    2013-11-01

    Purpose: Photon therapy has been reported to induce resets of implanted cardiac devices, but the clinical sequelae of treating patients with such devices with proton beam therapy (PBT) are not well known. We reviewed the incidence of device malfunctions among patients undergoing PBT. Methods and Materials: From March 2009 through July 2012, 42 patients with implanted cardiac implantable electronic devices (CIED; 28 pacemakers and 14 cardioverter-defibrillators) underwent 42 courses of PBT for thoracic (23, 55%), prostate (15, 36%), liver (3, 7%), or base of skull (1, 2%) tumors at a single institution. The median prescribed dose was 74 Gy (relative biological effectiveness; range 46.8-87.5 Gy), and the median distance from the treatment field to the CIED was 10 cm (range 0.8-40 cm). Maximum proton and neutron doses were estimated for each treatment course. All CIEDs were checked before radiation delivery and monitored throughout treatment. Results: Median estimated peak proton and neutron doses to the CIED in all patients were 0.8 Gy (range 0.13-21 Gy) and 346 Sv (range 11-1100 mSv). Six CIED malfunctions occurred in 5 patients (2 pacemakers and 3 defibrillators). Five of these malfunctions were CIED resets, and 1 patient with a defibrillator (in a patient with a liver tumor) had an elective replacement indicator after therapy that was not influenced by radiation. The mean distance from the proton beam to the CIED among devices that reset was 7.0 cm (range 0.9-8 cm), and the mean maximum neutron dose was 655 mSv (range 330-1100 mSv). All resets occurred in patients receiving thoracic PBT and were corrected without clinical incident. The generator for the defibrillator with the elective replacement indicator message was replaced uneventfully after treatment. Conclusions: The incidence of CIED resets was about 20% among patients receiving PBT to the thorax. We recommend that PBT be avoided in pacing-dependent patients and that patients with any type of CIED receiving

  12. Diamond detector in absorbed dose measurements in high-energy linear accelerator photon and electron beams.

    PubMed

    Ravichandran, Ramamoorthy; Binukumar, John Pichy; Al Amri, Iqbal; Davis, Cheriyathmanjiyil Antony

    2016-03-08

    Diamond detectors (DD) are preferred in small field dosimetry of radiation beams because of small dose profile penumbras, better spatial resolution, and tissue-equivalent properties. We investigated a commercially available 'microdiamond' detector in realizing absorbed dose from first principles. A microdiamond detector, type TM 60019 with tandem electrometer is used to measure absorbed doses in water, nylon, and PMMA phantoms. With sensitive volume 0.004 mm3, radius 1.1mm, thickness 1 x10(-3) mm, the nominal response is 1 nC/Gy. It is assumed that the diamond detector could collect total electric charge (nC) developed during irradiation at 0 V bias. We found that dose rate effect is less than 0.7% for changing dose rate by 500 MU/min. The reproducibility in obtaining readings with diamond detector is found to be ± 0.17% (1 SD) (n = 11). The measured absorbed doses for 6 MV and 15 MV photons arrived at using mass energy absorption coefficients and stop-ping power ratios compared well with Nd, water calibrated ion chamber measured absorbed doses within 3% in water, PMMA, and nylon media. The calibration factor obtained for diamond detector confirmed response variation is due to sensitivity due to difference in manufacturing process. For electron beams, we had to apply ratio of electron densities of water to carbon. Our results qualify diamond dosimeter as a transfer standard, based on long-term stability and reproducibility. Based on micro-dimensions, we recommend these detectors for pretreatment dose verifications in small field irradiations like stereotactic treatments with image guidance.

  13. Physical and engineering aspect of carbon beam therapy

    NASA Astrophysics Data System (ADS)

    Kanai, Tatsuaki; Kanematsu, Nobuyuki; Minohara, Shinichi; Yusa, Ken; Urakabe, Eriko; Mizuno, Hideyuki; Iseki, Yasushi; Kanazawa, Mitsutaka; Kitagawa, Atsushi; Tomitani, Takehiro

    2003-08-01

    Conformal irradiation system of HIMAC has been up-graded for a clinical trial using a technique of a layer-stacking method. The system has been developed for localizing irradiation dose to target volume more effectively than the present irradiation dose. With dynamic control of the beam modifying devices, a pair of wobbler magnets, and multileaf collimator and range shifter, during the irradiation, more conformal radiotherapy can be achieved. The system, which has to be adequately safe for patient irradiations, was constructed and tested from a viewpoint of safety and the quality of the dose localization realized. A secondary beam line has been constructed for use of radioactive beam in heavy-ion radiotherapy. Spot scanning method has been adapted for the beam delivery system of the radioactive beam. Dose distributions of the spot beam were measured and analyzed taking into account of aberration of the beam optics. Distributions of the stopped positron-emitter beam can be observed by PET. Pencil beam of the positron-emitter, about 1 mm size, can also be used for measurements ranges of the test beam in patients using positron camera. The positron camera, consisting of a pair of Anger-type scintillation detectors, has been developed for this verification before treatment. Wash-out effect of the positron-emitter was examined using the positron camera installed. In this report, present status of the HIMAC irradiation system is described in detail.

  14. Physical and engineering aspect of carbon beam therapy

    SciTech Connect

    Kanai, Tatsuaki; Kanematsu, Nobuyuki; Minohara, Shinichi; Yusa, Ken; Urakabe, Eriko; Kanazawa, Mitsutaka; Kitagawa, Atsushi; Tomitani, Takehiro; Mizuno, Hideyuki; Iseki, Yasushi

    2003-08-26

    Conformal irradiation system of HIMAC has been up-graded for a clinical trial using a technique of a layer-stacking method. The system has been developed for localizing irradiation dose to target volume more effectively than the present irradiation dose. With dynamic control of the beam modifying devices, a pair of wobbler magnets, and multileaf collimator and range shifter, during the irradiation, more conformal radiotherapy can be achieved. The system, which has to be adequately safe for patient irradiations, was constructed and tested from a viewpoint of safety and the quality of the dose localization realized. A secondary beam line has been constructed for use of radioactive beam in heavy-ion radiotherapy. Spot scanning method has been adapted for the beam delivery system of the radioactive beam. Dose distributions of the spot beam were measured and analyzed taking into account of aberration of the beam optics. Distributions of the stopped positron-emitter beam can be observed by PET. Pencil beam of the positron-emitter, about 1 mm size, can also be used for measurements ranges of the test beam in patients using positron camera. The positron camera, consisting of a pair of Anger-type scintillation detectors, has been developed for this verification before treatment. Wash-out effect of the positron-emitter was examined using the positron camera installed. In this report, present status of the HIMAC irradiation system is described in detail.

  15. Proton Beam Therapy and Accountable Care: The Challenges Ahead

    SciTech Connect

    Elnahal, Shereef M.; Kerstiens, John; Helsper, Richard S.; Zietman, Anthony L.; Johnstone, Peter A.S.

    2013-03-15

    Purpose: Proton beam therapy (PBT) centers have drawn increasing public scrutiny for their high cost. The behavior of such facilities is likely to change under the Affordable Care Act. We modeled how accountable care reform may affect the financial standing of PBT centers and their incentives to treat complex patient cases. Methods and Materials: We used operational data and publicly listed Medicare rates to model the relationship between financial metrics for PBT center performance and case mix (defined as the percentage of complex cases, such as pediatric central nervous system tumors). Financial metrics included total daily revenues and debt coverage (daily revenues − daily debt payments). Fee-for-service (FFS) and accountable care (ACO) reimbursement scenarios were modeled. Sensitivity analyses were performed around the room time required to treat noncomplex cases: simple (30 minutes), prostate (24 minutes), and short prostate (15 minutes). Sensitivity analyses were also performed for total machine operating time (14, 16, and 18 h/d). Results: Reimbursement under ACOs could reduce daily revenues in PBT centers by up to 32%. The incremental revenue gained by replacing 1 complex case with noncomplex cases was lowest for simple cases and highest for short prostate cases. ACO rates reduced this incremental incentive by 53.2% for simple cases and 41.7% for short prostate cases. To cover daily debt payments after ACO rates were imposed, 26% fewer complex patients were allowable at varying capital costs and interest rates. Only facilities with total machine operating times of 18 hours per day would cover debt payments in all scenarios. Conclusions: Debt-financed PBT centers will face steep challenges to remain financially viable after ACO implementation. Paradoxically, reduced reimbursement for noncomplex cases will require PBT centers to treat more such cases over cases for which PBT has demonstrated superior outcomes. Relative losses will be highest for those

  16. Highly indistinguishable photons from deterministic quantum-dot microlenses utilizing three-dimensional in situ electron-beam lithography

    PubMed Central

    Gschrey, M.; Thoma, A.; Schnauber, P.; Seifried, M.; Schmidt, R.; Wohlfeil, B.; Krüger, L.; Schulze, J. -H.; Heindel, T.; Burger, S.; Schmidt, F.; Strittmatter, A.; Rodt, S.; Reitzenstein, S.

    2015-01-01

    The success of advanced quantum communication relies crucially on non-classical light sources emitting single indistinguishable photons at high flux rates and purity. We report on deterministically fabricated microlenses with single quantum dots inside which fulfil these requirements in a flexible and robust quantum device approach. In our concept we combine cathodoluminescence spectroscopy with advanced in situ three-dimensional electron-beam lithography at cryogenic temperatures to pattern monolithic microlenses precisely aligned to pre-selected single quantum dots above a distributed Bragg reflector. We demonstrate that the resulting deterministic quantum-dot microlenses enhance the photon-extraction efficiency to (23±3)%. Furthermore we prove that such microlenses assure close to pure emission of triggered single photons with a high degree of photon indistinguishability up to (80±7)% at saturation. As a unique feature, both single-photon purity and photon indistinguishability are preserved at high excitation power and pulsed excitation, even above saturation of the quantum emitter. PMID:26179766

  17. Dynamic PET/CT measurements of induced positron activity in a prostate cancer patient after 50-MV photon radiation therapy

    PubMed Central

    2013-01-01

    Background The purpose of this work was to reveal the research interest value of positron emission tomography (PET) imaging in visualizing the induced tissue activity post high-energy photon radiation treatment. More specifically, the focus was on the possibility of retrieving data such as tissue composition and physical half-lives from dynamic PET acquisitions, as positron-emitting radionuclides such as 15O, 11C, and 13N are produced in vivo during radiation treatment with high-energy photons (>15 MeV). The type, amount, and distribution of induced positron-emitting radionuclides depend on the irradiated tissue cross section, the photon spectrum, and the possible perfusion-driven washout. Methods A 62-year-old man diagnosed with prostate cancer was referred for palliative radiation treatment of the pelvis minor. A total dose of 8 Gy was given using high-energy photon beams (50 MV) with a racetrack microtron, and 7 min after the end of irradiation, the patient was positioned in a PET/computed tomography (CT) camera, and a list-mode acquisition was performed for 30 min. Two volumes of interests (VOIs) were positioned on the dynamic PET/CT images, one in the urinary bladder and the other in the subcutaneous fat. Analysis of the measured relative count rate was performed in order to compute the tissue compositions and physical half-lives in the two regions. Results Dynamic analysis from the two VOIs showed that the decay constants of activated oxygen and carbon could be deduced. Calculation of tissue composition from analyzing the VOI containing subcutaneous fat only moderately agreed with that of the tabulated International Commission on Radiation Units & Measurements (ICRU) data of the adipose tissue. However, the same analysis for the bladder showed a good agreement with that of the tabulated ICRU data. Conclusions PET can be used in visualizing the induced activity post high-energy photon radiation treatment. Despite the very low count rate in this specific

  18. Comparison of characteristics of photon and electron beams generated by Philips/Elekta and Varian linear accelerators.

    PubMed

    Song, Haijun; Xiao, Ying; Galvin, James M

    2002-06-01

    Commissioning data of the common energy of 6 MV photon beams are analyzed for seven Philips/ Elekta linacs of five different models: SL 75/5, SL 15, SL 25, SLi Precise, and SLi. The observed beam quality %dd(10)x of 67.7% +/- 0.3 agrees with the manufacturer's specification of 67.5% +/- 2% but with a much smaller variation, suggesting the possibility of a more accurate beam quality guideline for acceptance commissioning of these linac models. Field size factors are less uniform, especially for the biggest field size of 40 x 40 cm2, but all agree within 1.1% between the five models. These 6 MV photon beams are also shown to be 0.4 MV harder than the Varian 2100C model. For commissioning electron beams generated by the Philips/Elekta models SL 15, SLi Precise and SLi, guidelines can be found from this work for the following parameters: actual field size at 100 SSD (up to +/- 0.6%) (different from manufacturer specified values at 95 SSD), and virtual source distance (up to +/- 0.7%). Significant differences are seen for R50 (up to 3.7 mm), sigma-theta-x, effective source distance, and cone size factor. However, except for R50 where Varian 2100C datasets are not available for comparison, the differences between the different Philips/Elekta models are comparable to those between the same Varian 2100C model linacs measured by us and Watts.

  19. [Measurement of peak correction factor of Farmer chamber for calibration of flattening filter free (FFF) clinical photon beams].

    PubMed

    Kontra, Gábor; Major, Tibor; Polgár, Csaba

    2015-06-01

    Farmer-type ionization chambers are considered the most reliable detectors and for this reason they are most frequently used for the calibration of photon beams of medical linear accelerators. Flattening filter free (FFF) photon beams of linear accelerators have recently started to be used in radiotherapy. The dose profile of FFF beams is peaked in the center of the field and the dose distribution will be inhomogeneous along the axis of the 2.3 cm long measuring volume of the Farmer chamber. The peaked radiation field will result in volume averaging effects in the large Farmer chamber, therefore this chamber will underestimate the true central axis dose. Our objective was to determine the value of the peak correction factor (Kp) of Farmer-type chamber with measurements to avoid the underestimation of the central axis dose during the calibration of FFF radiation fields. Measurements were made with 6 MV and 10 MV flattened (6X and 10X) and FFF beams (6XFFF and 10XFFF) of a Varian TrueBeam medical linear accelerator in a solid water phantom at 10 cm depth. The source surface distance (SSD) was 100 cm, the field size was 10×10 cm and the dose rate was always 400 MU/min during the measurements. We delivered 100 MU in each measurement and the absorbed dose to water was calculated according to the IAEA TRS-398 dosimetry protocol. The measured signals of the ionization chambers were always corrected for the ion recombination loss. The ion recombination correction factors (Kr) were determined with the two-voltage method separately for the used ion chambers and for flattened and unflattened beams. First, we measured the dose to water with PTW TM30012 Farmer chamber in 6XFFF and 6X beams, then calculated the ratio of doses of 6XFFF and 6X beams (R6,Farmer). Immediately after this we repeated the above measurements with PTW TM31010 Semiflex chamber and determined the ratio of doses of 6XFFF and 6X beams again (R6,Semiflex). The length of the sensitive volume of the Semiflex

  20. Quantum correlations by four-wave mixing in an atomic vapor in a nonamplifying regime: Quantum beam splitter for photons

    SciTech Connect

    Glorieux, Quentin; Guidoni, Luca; Guibal, Samuel; Likforman, Jean-Pierre; Coudreau, Thomas

    2011-11-15

    We study the generation of intensity quantum correlations using four-wave mixing in a rubidium vapor. The absence of cavities in these experiments allows to deal with several spatial modes simultaneously. In the standard amplifying configuration, we measure relative intensity squeezing up to 9.2 dB below the standard quantum limit. We also theoretically identify and experimentally demonstrate an original regime where, despite no overall amplification, quantum correlations are generated. In this regime, a four-wave mixing setup can play the role of a photonic beam splitter with nonclassical properties, that is, a device that splits a coherent state input into two quantum-correlated beams.

  1. Micro-metric electronic patterning of a topological band structure using a photon beam

    NASA Astrophysics Data System (ADS)

    Golden, Mark; Frantzeskakis, Emmanouil; de Jong, Nick; Huang, Yingkai; Wu, Dong; Pan, Yu; de Visser, Anne; van Heumen, Erik; van Bay, Tran; Zwartsenberg, Berend; Pronk, Pieter; Varier Ramankutty, Shyama; Tytarenko, Alona; Xu, Nan; Plumb, Nick; Shi, Ming; Radovic, Milan; Varkhalov, Andrei

    2015-03-01

    The only states crossing EF in ideal, 3D TIs are topological surface states. Single crystals of Bi2Se3andBi2Te3 are too defective to exhibit bulk-insulating behaviour, and ARPES shows topologically trivial 2DEGs at EF in the surface region due to downward band bending. Ternary & quaternary alloys of Bi /Te /Se /Sb hold promise for obtaining bulk-insulating crystals. Here we report ARPES data from quaternary, bulk-insulating, Bi-based TIs. Shortly after cleavage in UHV, downward band bending pulls the bulk conduction band below EF, once again frustrating the ``topological only'' ambition for the Fermi surface. However, there is light at the end of the tunnel: we show that a super-band-gap photon beam generates a surface photovoltage sufficient to flatten the bands, thereby recovering the ideal, ``topological only'' situation. In our bulk-insulating quaternary TIs, this effect is local in nature, and permits the writing of arbitrary, micron-sized patterns in the topological energy landscape at the surface. Support from FOM, NWO and the EU is gratefully acknowledged.

  2. Note: Spectrometer with multichannel photon-counting detector for beam emission spectroscopy in magnetic fusion devices

    SciTech Connect

    Lizunov, A.; Khilchenko, A.; Khilchenko, V.; Kvashnin, A.; Zubarev, P.

    2015-12-15

    A spectrometer based on a linear array photomultiplier tube (PMT) has been developed and calibrated. A 0.635 m focal length Czerny-Turner monochromator combined with a coupling optics provides an image of a narrow 0.5 nm spectral range with a resolution of 0.015 nm/channel on a 32-anode PMT. The system aims at spectroscopy of D{sub α} or H{sub α} lines emitted by a diagnostic atomic beam in a plasma (primarily a motional Stark effect diagnostics). To record a low photon flux of ∼10{sup 6} s{sup −1} per channel with the time resolution of 100 μs, a pulse counting approach has been used. Wideband amplifiers scale single-electron pulses and transmit them to a digital data processing core hardwired in a programmable logic matrix. Calibrations have shown that the aberration-limited instrument function fits to a single detector channel of 1 mm width. Pilot results of passive measurements of D{sub α} light emission from the plasma confined in a magnetic trap are presented.

  3. The practical application of scintillation dosimetry in small-field photon-beam radiotherapy.

    PubMed

    Burke, Elisa; Poppinga, Daniela; Schönfeld, Andreas A; Harder, Dietrich; Poppe, Björn; Looe, Hui Khee

    2017-03-22

    Plastic scintillation detectors are a new instrument of stereotactic photon-beam dosimetry. The clinical application of the plastic scintillation detector Exradin W1 at the Siemens Artiste and Elekta Synergy accelerators is a matter of current interest. In order to reduce the measurement uncertainty, precautions have to be taken with regard to the geometrical arrangement of the scintillator, the light-guide fiber and the photodiode in the radiation field. To determine the "Cerenkov light ratio" CLR with a type A uncertainty below 1%, the Cerenkov calibration procedure for small-field measurements based on the two-channel spectral method was used. Output factors were correctly measured with the W1 for field sizes down to 0.5×0.5cm(2) with a type A uncertainty of 1.8%. Measurements of small field dose profiles and percentage depth dose curves were carried out with the W1 using automated water phantom profile scans, and a type A uncertainty for dose maxima of 1.4% was achieved. The agreement with a synthetic diamond detector (microDiamond, PTW Freiburg) and a plane parallel ionization chamber (Roos chamber, PTW Freiburg) in relative dose measurements was excellent. In oversight of all results, the suitability of the plastic scintillation detector Exradin W1 for clinical dosimetry under stereotactic conditions, in particular the tried and tested procedures for CLR determination, output factor measurement and automated dose profile scans in water phantoms, have been confirmed.

  4. Note: Spectrometer with multichannel photon-counting detector for beam emission spectroscopy in magnetic fusion devices

    NASA Astrophysics Data System (ADS)

    Lizunov, A.; Khilchenko, A.; Khilchenko, V.; Kvashnin, A.; Zubarev, P.

    2015-12-01

    A spectrometer based on a linear array photomultiplier tube (PMT) has been developed and calibrated. A 0.635 m focal length Czerny-Turner monochromator combined with a coupling optics provides an image of a narrow 0.5 nm spectral range with a resolution of 0.015 nm/channel on a 32-anode PMT. The system aims at spectroscopy of Dα or Hα lines emitted by a diagnostic atomic beam in a plasma (primarily a motional Stark effect diagnostics). To record a low photon flux of ˜106 s-1 per channel with the time resolution of 100 μs, a pulse counting approach has been used. Wideband amplifiers scale single-electron pulses and transmit them to a digital data processing core hardwired in a programmable logic matrix. Calibrations have shown that the aberration-limited instrument function fits to a single detector channel of 1 mm width. Pilot results of passive measurements of Dα light emission from the plasma confined in a magnetic trap are presented.

  5. Experimental Observations of Nuclear Activity in Deuterated Materials Subjected to a Low-Energy Photon Beam

    NASA Technical Reports Server (NTRS)

    Steinetz, Bruce M.; Benyo, Theresa L.; Pines, Vladimir; Pines, Marianna; Forsley, Lawrence P.; Westmeyer, Paul A.; Chait, Arnon; Becks, Michael D.; Martin, Richard E.; Hendricks, Robert C.; Penney, Nicholas; Marsolais, Annette M.; Kamm, Tracy R.

    2017-01-01

    Exposure of highly deuterated materials to a low-energy (nom. 2 MeV) photon beam resulted in nuclear activity of both the parent metals of hafnium and erbium and a witness material (molybdenum) mixed with the reactants. Gamma spectral analysis of all deuterated materials, ErD2.8+C36D74+Mo and HfD2+C36D74+Mo, showed that nuclear processes had occurred as shown by unique gamma signatures. For the deuterated erbium specimens, posttest gamma spectra showed evidence of radioisotopes of erbium ((163)Er and (171)Er) and of molybdenum ((99)Mo and (101)Mo) and by beta decay, technetium (99mTc and 101Tc). For the deuterated hafnium specimens, posttest gamma spectra showed evidence of radioisotopes of hafnium (180mHf and 181Hf) and molybdenum ((99)Mo and (101)Mo), and by beta decay, technetium ((99m)Tc and (101)Tc). In contrast, when either the hydrogenated or non-gas-loaded erbium or hafnium materials were exposed to the gamma flux, the gamma spectra revealed no new isotopes. Neutron activation materials showed evidence of thermal and epithermal neutrons. CR-39 solid-state nuclear track detectors showed evidence of fast neutrons with energies between 1.4 and 2.5 MeV and several instances of triple tracks, indicating (is) greater than 10 MeV neutrons. Further study is required to determine the mechanism causing the nuclear activity.

  6. Treatment of extensive scalp lesions with segmental intensity-modulated photon therapy

    SciTech Connect

    Bedford, James L. . E-mail: James.Bedford@icr.ac.uk; Childs, Peter J.; Hansen, Vibeke Nordmark; Warrington, Alan P.; Mendes, Ruheena L.; Glees, John P.

    2005-08-01

    Purpose: To compare static electron therapy, electron arc therapy, and photon intensity-modulated radiation therapy (IMRT) for treatment of extensive scalp lesions and to examine the dosimetric accuracy of the techniques. Methods and Materials: A retrospective treatment-planning study was performed to evaluate the relative merits of static electron fields, arcing electron fields, and five-field photon IMRT. Thermoluminescent dosimeters (TLD) were used to verify the accuracy of the techniques. The required thickness of bolus was investigated, and an anthropomorphic phantom was also used to examine the effects of air gaps between the wax bolus used for the IMRT technique and the patient's scalp. Results: Neither static nor arcing electron techniques were able to provide a reliable coverage of the planning target volume (PTV), owing to obliquity of the fields in relation to the scalp. The IMRT technique considerably improved PTV dose uniformity, though it irradiated a larger volume of brain. Either 0.5 cm or 1.0 cm of wax bolus was found to be suitable. Air gaps of up to 1 cm between the bolus and the patient's scalp were correctly handled by the treatment-planning system and had negligible influence on the dose to the scalp. Conclusions: Photon IMRT provides a feasible alternative to electron techniques for treatment of large scalp lesions, resulting in improved homogeneity of dose to the PTV but with a moderate increase in dose to the brain.

  7. Relative measurements of fast neutron contamination in 18-MV photon beams from two linear accelerators and a betatron.

    PubMed

    Gur, D; Bukovitz, G; Rosen, J C; Holmes, B G

    1979-01-01

    Fast neutron contamination in photon beams in the 20 MV range have been reported in recent years. In order to determine if the variations were due mainly to differences in measurement procedures, or inherent in the design of the accelerators, three different 18-MV (BJR) photon beams were compared using identical analytical techniques. The units studied were a Philips SL/75-20 and a Siemens Mevatron-20 linear accelerators and a Schimadzu betatron. Gamma spectroscopy of an activated aluminum foil was the method used. By comparing the relative amounts of neutron contamination, errors associated with absolute measurements such as detector efficiency and differences in activation foils were eliminated. Fast neutron contaminations per rad of x rays in a ratio of 6.7:3.7:1 were found for the Philips, Schimadzu and Siemens accelerators, respectively.

  8. Measurement of therapeutic photon beams-induced Cerenkov radiation generated in PMMA- and PS-based plastic optical fibers

    NASA Astrophysics Data System (ADS)

    Lee, Bongsoo; Shin, Sang Hun; Yoo, Wook Jae; Jang, Kyoung Won

    2016-10-01

    In this study, we characterized Cerenkov radiation generated in polystyrene (PS)- and polymethyl methacrylate (PMMA)-based plastic optical fibers (POFs) to select an adequate optical fiber for producing Cerenkov radiation. To determine the relationship between the absorbed dose and the intensity of Cerenkov radiation, we calculated the energy depositions of photon beams and fluxes of electrons inducing Cerenkov radiation using the Monte Carlo N-Particle eXtended code. Also, intensities of Cerenkov radiation generated in PS- and PMMA-based POFs were measured as functions of dose rate and monitor unit. At last, therapeutic photon beams-induced Cerenkov radiation in PS- and PMMA-based POFs was measured according to depths of solid water phantom.

  9. Dosimetric variation due to the photon beam energy in the small-animal irradiation: A Monte Carlo study

    SciTech Connect

    Chow, James C. L.; Leung, Michael K. K.; Lindsay, Patricia E.; Jaffray, David A.

    2010-10-15

    Purpose: The impact of photon beam energy and tissue heterogeneities on dose distributions and dosimetric characteristics such as point dose, mean dose, and maximum dose was investigated in the context of small-animal irradiation using Monte Carlo simulations based on the EGSnrc code. Methods: Three Monte Carlo mouse phantoms, namely, heterogeneous, homogeneous, and bone homogeneous were generated based on the same mouse computed tomography image set. These phantoms were generated by overriding the tissue type of none of the voxels (heterogeneous), all voxels (homogeneous), and only the bone voxels (bone homogeneous) to that of soft tissue. Phase space files of the 100 and 225 kVp photon beams based on a small-animal irradiator (XRad225Cx, Precision X-Ray Inc., North Branford, CT) were generated using BEAMnrc. A 360 deg. photon arc was simulated and three-dimensional (3D) dose calculations were carried out using the DOSXYZnrc code through DOSCTP in the above three phantoms. For comparison, the 3D dose distributions, dose profiles, mean, maximum, and point doses at different locations such as the isocenter, lung, rib, and spine were determined in the three phantoms. Results: The dose gradient resulting from the 225 kVp arc was found to be steeper than for the 100 kVp arc. The mean dose was found to be 1.29 and 1.14 times higher for the heterogeneous phantom when compared to the mean dose in the homogeneous phantom using the 100 and 225 kVp photon arcs, respectively. The bone doses (rib and spine) in the heterogeneous mouse phantom were about five (100 kVp) and three (225 kVp) times higher when compared to the homogeneous phantom. However, the lung dose did not vary significantly between the heterogeneous, homogeneous, and bone homogeneous phantom for the 225 kVp compared to the 100 kVp photon beams. Conclusions: A significant bone dose enhancement was found when the 100 and 225 kVp photon beams were used in small-animal irradiation. This dosimetric effect, due to

  10. External Beam Radiation Therapy Enhances Local Control in Pigmented Villonodular Synovitis

    SciTech Connect

    Horoschak, Melissa; Tran, Phuoc T. Bachireddy, Pavan; West, Robert B.; Mohler, David; Beaulieu, Christopher F.; Kapp, Daniel S.; Donaldson, Sarah S.

    2009-09-01

    Purpose: Pigmented villonodular synovitis (PVNS) is a rare proliferative disorder of the synovium with locally aggressive behavior. We reviewed our experience using radiation therapy in the treatment of PVNS. Materials and Methods: Seventeen patients with 18 sites of PVNS were treated with radiation between 1993 and 2007. Cases were retrospectively reviewed for patient information, treatment parameters, complications, and outcome. Seven sites were primary presentations and 11 were recurrent with an average of 2.5 prior surgical interventions. The most common location was the knee joint (67%). Cytoreductive surgery was performed before radiation therapy in 16/18 sites with all having proven or suspected residual disease. Radiation was delivered using 4-15 MV photons with an average total dose 34 Gy (range, 20-36 Gy). Seventeen of 18 sites (94%) had postradiotherapy imaging. Results: With average follow-up of 46 months (range, 8-181 months), initial local control was achieved in 75% (12/16) of the sites with prior cytoreductive surgery (mean time to recurrence, 38 months). Ultimate local control was 100% after repeat resection (mean follow-up, 61 months). Two additional sites without prior cytoreductive surgery showed growth after radiotherapy (mean time to documented growth, 10.5 months). Seventeen of the 18 involved joints (94%) were scored as excellent or good PVNS-related function, one site (5%) as fair function, and no site with poor function. No patient required amputation; and there were no Grade 3/4 treatment-related complications. Conclusion: Postoperative external beam radiation is effective in preventing disease recurrence and should be offered following maximal cytoreduction to enhance local control in PVNS.

  11. On the role of ion-based imaging methods in modern ion beam therapy

    NASA Astrophysics Data System (ADS)

    Magallanes, L.; Brons, S.; Marcelos, T.; Takechi, M.; Voss, B.; Jäkel, O.; Rinaldi, I.; Parodi, K.

    2014-11-01

    External beam radiotherapy techniques have the common aim to maximize the radiation dose to the target while sparing the surrounding healthy tissues. The inverted and finite depth-dose profile of ion beams (Bragg peak) allows for precise dose delivery and conformai dose distribution. Furthermore, increased radiobiological effectiveness of ions enhances the capability to battle radioresistant tumors. Ion beam therapy requires a precise determination of the ion range, which is particularly sensitive to range uncertainties. Therefore, novel imaging techniques are currently investigated as a tool to improve the quality of ion beam treatments. Approaches already clinically available or under development are based on the detection of secondary particles emitted as a result of nuclear reactions (e.g., positron-annihilation or prompt gammas, charged particles) or transmitted high energy primary ion beams. Transmission imaging techniques make use of the beams exiting the patient, which have higher initial energy and lower fluence than the therapeutic ones. At the Heidelberg Ion Beam Therapy Center, actively scanned energetic proton and carbon ion beams provide an ideal environment for the investigation of ion-based radiography and tomography. This contribution presents the rationale of ion beam therapy, focusing on the role of ion-based transmission imaging methods towards the reduction of range uncertainties and potential improvement of treatment planning.

  12. On the role of ion-based imaging methods in modern ion beam therapy

    SciTech Connect

    Magallanes, L. Rinaldi, I.; Brons, S.; Marcelos, T. Parodi, K.; Takechi, M.; Voss, B.; Jäkel, O.

    2014-11-07

    External beam radiotherapy techniques have the common aim to maximize the radiation dose to the target while sparing the surrounding healthy tissues. The inverted and finite depth-dose profile of ion beams (Bragg peak) allows for precise dose delivery and conformai dose distribution. Furthermore, increased radiobiological effectiveness of ions enhances the capability to battle radioresistant tumors. Ion beam therapy requires a precise determination of the ion range, which is particularly sensitive to range uncertainties. Therefore, novel imaging techniques are currently investigated as a tool to improve the quality of ion beam treatments. Approaches already clinically available or under development are based on the detection of secondary particles emitted as a result of nuclear reactions (e.g., positron-annihilation or prompt gammas, charged particles) or transmitted high energy primary ion beams. Transmission imaging techniques make use of the beams exiting the patient, which have higher initial energy and lower fluence than the therapeutic ones. At the Heidelberg Ion Beam Therapy Center, actively scanned energetic proton and carbon ion beams provide an ideal environment for the investigation of ion-based radiography and tomography. This contribution presents the rationale of ion beam therapy, focusing on the role of ion-based transmission imaging methods towards the reduction of range uncertainties and potential improvement of treatment planning.

  13. Transfer of the UK absorbed dose primary standard for photon beams from the research linac to the clinical linac at NPL

    NASA Astrophysics Data System (ADS)

    Pearce, J. A. D.; Shipley, D. R.; Duane, S.

    2011-10-01

    An Elekta Synergy clinical linac facility is now in routine use at the National Physical Laboratory (NPL). For the purpose of therapy-level dosimetry, this has replaced the NPL research linac, which is over 40 years old, and in which the NPL absorbed dose primary standard for high-energy photons was established. This standard has been disseminated to clinical beams by interpolation of the calibration factor as a function of tissue phantom ratio TPR20/10. In this work the absorbed dose standard has been commissioned in all the beams produced by the Elekta Synergy linac. Reference standard ionization chambers have been calibrated in terms of absorbed dose to graphite and this calibration has been converted to one in terms of absorbed dose to water. The results have been combined with the calibration in 60Co γ-rays to obtain measured values for the quality-dependent correction, kQ, for these reference standard chambers used in the Elekta beams. The resulting data are consistent with the interpolated kQ to within 0.4%, which is less than the combined standard uncertainty of kQ, 0.56%.

  14. Rb based alkali antimonide high quantum efficiency photocathodes for bright electron beam sources and photon detection applications

    NASA Astrophysics Data System (ADS)

    Cultrera, L.; Gulliford, C.; Bartnik, A.; Lee, H.; Bazarov, I.

    2017-02-01

    High quantum efficiency alkali antimonide photocathodes have been grown over both stainless steel and glass substrates using sequential evaporation of Sb, K, Rb, and Cs. Quantum efficiencies well above 25% have been measured at 400 nm. A bi-alkali Rb-K-Sb photocathode grown on a stainless steel substrate has been installed in a high voltage DC gun at Cornell University and the intrinsic electron beam emittance was measured at different photon energies.

  15. Calibration of Fast Fiber-Optic Beam Loss Monitors for the Advanced Photon Source Storage Ring Superconducting Undulators

    SciTech Connect

    Dooling, J.; Harkay, K.; Ivanyushenkov, Y.; Sajaev, V.; Xiao, A.; Vella, Andrea K.

    2015-01-01

    We report on the calibration and use of fast fiber-optic (FO) beam loss monitors (BLMs) in the Advanced Photon Source storage ring (SR). A superconducting undulator prototype (SCU0) has been operating in SR Sector 6 (“ID6”) since the beginning of CY2013, and another undulator SCU1 (a 1.1-m length undulator that is three times the length of SCU0) is scheduled for installation in Sector 1 (“ID1”) in 2015. The SCU0 main coil often quenches during beam dumps. MARS simulations have shown that relatively small beam loss (<1 nC) can lead to temperature excursions sufficient to cause quenchingwhen the SCU0windings are near critical current. To characterize local beam losses, high-purity fused-silica FO cables were installed in ID6 on the SCU0 chamber transitions and in ID1 where SCU1 will be installed. These BLMs aid in the search for operating modes that protect the SCU structures from beam-loss-induced quenching. In this paper, we describe the BLM calibration process that included deliberate beam dumps at locations of BLMs. We also compare beam dump events where SCU0 did and did not quench.

  16. Photonic dual RF beam reception of an X band phased array antenna using a photonic crystal fiber-based true-time-delay beamformer.

    PubMed

    Subbaraman, Harish; Chen, Maggie Yihong; Chen, Ray T

    2008-12-01

    We report dual RF beam reception of an X band phased array antenna using a photonic crystal fiber (PCF)-based delay network. Each incoming RF signal can be independently received, and the angle of arrival can be determined based on the delay time-dependent wavelength. Two RF signals with frequencies 8.4 and 12 GHz impinge upon an X-band antenna array from -7.4 degrees and -21.2 degrees . These signals are detected, and the angle of arrival is determined with a very good degree of accuracy using PCF-based true-time delay. The total number of RF beams that can be simultaneously detected is limited by the hardware availability and the bandwidth of the wavelength differentiation capability of the system.

  17. Optical beam induced current measurements based on two-photon absorption process in 4H-SiC bipolar diodes

    SciTech Connect

    Hamad, H.; Raynaud, C.; Bevilacqua, P.; Tournier, D.; Planson, D.; Vergne, B.

    2014-02-24

    Using a pulsed green laser with a wavelength of 532 nm, a duration pulse of ∼1 ns, and a mean power varying between 1 and 100 mW, induced photocurrents have been measured in 4H-SiC bipolar diodes. Considering the photon energy (2.33 eV) and the bandgap of 4H-SiC (3.2 eV), the generation of electron-hole pair by the conventional single photon absorption process should be negligible. The intensity of the measured photocurrents depends quadratically on the power beam intensity. This clearly shows that they are generated using two-photon absorption process. As in conventional OBIC (Optical Beam Induced Current), the measurements give an image of the electric field distribution in the structure under test, and the minority carrier lifetime can be extracted from the decrease of the photocurrent at the edge of the structure. The extracted minority carrier lifetime of 210 ns is consistent with results obtained in case of single photon absorption.

  18. Imaging and characterization of primary and secondary radiation in ion beam therapy

    NASA Astrophysics Data System (ADS)

    Granja, Carlos; Martisikova, Maria; Jakubek, Jan; Opalka, Lukas; Gwosch, Klaus

    2016-07-01

    Imaging in ion beam therapy is an essential and increasingly significant tool for treatment planning and radiation and dose deposition verification. Efforts aim at providing precise radiation field characterization and online monitoring of radiation dose distribution. A review is given of the research and methodology of quantum-imaging, composition, spectral and directional characterization of the mixed-radiation fields in proton and light ion beam therapy developed by the IEAP CTU Prague and HIT Heidelberg group. Results include non-invasive imaging of dose deposition and primary beam online monitoring.

  19. SU-E-J-91: Novel Epitaxial Silicon Array for Quality Assurance in Photon and Proton Therapy

    SciTech Connect

    Talamonti, C; Zani, M; Scaringella, M; Bruzzi, M; Bucciolini, M; Menichelli, D; Friedl, F

    2014-06-01

    Purpose: to demonstrate suitability of a novel silicon array for measuring the dose properties of highly conformal photon and proton beams. Methods: prototype under test is a 24cm long linear array prototype, although the underlying technology is suitable to construct 2D arrays as well. It is based on a 64pixels monolithic sensor with 1mm pixel pitch, made of epitaxial ptype silicon. Thanks to design modularity, more sensors can be placed side by side without breaking pixel pitch. Flattened and unflattened photon beams, as well as proton radiation from a cyclotron in pencil beam scanning mode, were considered. Measurements of beam characteristics as percentage depth doses, dose profiles, output factors and energy response, which are necessary to deliver radiation with high precision and reliability, were performed. Results: Dose rate independence with photons was verified in the dose per pulse range 0.03 to 2mGy. Results clearly indicate nondependence of the detector sensitivity both for flattened and unflattened beams, with a variation of at most 0.5percentage. OFs were obtained for field with a lateral size ranging from 0.8cm to 16cm and the results are in good agreement with ion chamber A1SL, max difference less than 1.5percentage. Field sizes and beam penumbra were measured and compared to EBT film results. Concerning proton beams, sensitivity independence on dose rate was verified by changing the beam current in the interval 2-130Gy/s. Field sizes and beam penumbra measurements are in agreement with data taken with a scintillating 2D array with 0.5mm resolution IBA Lynx, and a better penumbra definition than an array of ionization chambers IBA MatriXX is reached. Conclusion: The device is a novel and valuable tool for QA both for photon and proton dose delivery. All measurements demonstrated its capability to measure with high spatial resolution many crucial properties of the RT beam.

  20. Comparison of Head Scatter Factor for 6MV and 10MV flattened (FB) and Unflattened (FFF) Photon Beam using indigenously Designed Columnar Mini Phantom

    PubMed Central

    Ashokkumar, Sigamani; Nambi Raj, N Arunai; Sinha, Sujit Nath; Yadav, Girigesh; Thiyagarajan, Rajesh; Raman, Kothanda; Mishra, Manindra Bhushan

    2014-01-01

    To measure and compare the head scatter factor for flattened (FB) and unflattened (FFF) of 6MV and 10MV photon beam using indigenously designed mini phantom. A columnar mini phantom was designed as recommended by AAPM Task Group 74 with low and high atomic number materials at 10 cm (mini phantom) and at approximately twice the depth of maximum dose water equivalent thickness (brass build-up cap). Scatter in the accelerator (Sc) values of 6MV-FFF photon beams are lesser than that of the 6MV-FB photon beams (0.66-2.8%; Clinac iX, 2300CD) and (0.47-1.74%; True beam) for field sizes ranging from 10 × 10 cm2 to 40 × 40 cm2. Sc values of 10MV-FFF photon beams are lesser (0.61-2.19%; True beam) than that of the 10MV-FB photons beams for field sizes ranging from 10 × 10 cm2 to 40 × 40 cm2. The SSD had no influence on head scatter for both flattened and unflattened beams and irrespective of head design of the different linear accelerators. The presence of field shaping device influences the Sc values. The collimator exchange effect reveals that the opening of the upper jaw increases Sc irrespective of FB or FFF photon beams and different linear accelerators, and it is less significant in FFF beams. Sc values of 6MV-FB square field were in good agreement with that of AAPM, TG-74 published data for Varian (Clinac iX, 2300CD) accelerator. Our results confirm that the removal of flattening filter decreases in the head scatter factor compared to flattened beam. This could reduce the out-of-field dose in advanced treatment delivery techniques. PMID:25190997

  1. Intelligence-guided beam angle optimization in treatment planning of intensity-modulated radiation therapy.

    PubMed

    Yan, Hui; Dai, Jian-Rong

    2016-10-01

    An intelligence guided approach based on fuzzy inference system (FIS) was proposed to automate beam angle optimization in treatment planning of intensity-modulated radiation therapy (IMRT). The model of FIS is built on inference rules in describing the relationship between dose quality of IMRT plan and irradiated region of anatomical structure. Dose quality of IMRT plan is quantified by the difference between calculated and constraint doses of the anatomical structures in an IMRT plan. Irradiated region of anatomical structure is characterized by the metric, covered region of interest, which is the region of an anatomical structure under radiation field while beam's eye-view is conform to target volume. Initially, an IMRT plan is created with a single beam. The dose difference is calculated for the input of FIS and the output of FIS is obtained with processing of fuzzy inference. Later, a set of candidate beams is generated for replacing the current beam. This process continues until no candidate beams is found. Then the next beam is added to the IMRT plan and optimized in the same way as the previous beam. The new beam keeps adding to the IMRT plan until the allowed beam number is reached. Two spinal cases were investigated in this study. The preliminary results show that dose quality of IMRT plans achieved by this approach is better than those achieved by the default approach with equally spaced beam setting. It is effective to find the optimal beam combination of IMRT plan with the intelligence-guided approach.

  2. Commissioning kilovoltage cone-beam CT beams in a radiation therapy treatment planning system.

    PubMed

    Alaei, Parham; Spezi, Emiliano

    2012-11-08

    The feasibility of accounting of the dose from kilovoltage cone-beam CT in treatment planning has been discussed previously for a single cone-beam CT (CBCT) beam from one manufacturer. Modeling the beams and computing the dose from the full set of beams produced by a kilovoltage cone-beam CT system requires extensive beam data collection and verification, and is the purpose of this work. The beams generated by Elekta X-ray volume imaging (XVI) kilovoltage CBCT (kV CBCT) system for various cassettes and filters have been modeled in the Philips Pinnacle treatment planning system (TPS) and used to compute dose to stack and anthropomorphic phantoms. The results were then compared to measurements made using thermoluminescent dosimeters (TLDs) and Monte Carlo (MC) simulations. The agreement between modeled and measured depth-dose and cross profiles is within 2% at depths beyond 1 cm for depth-dose curves, and for regions within the beam (excluding penumbra) for cross profiles. The agreements between TPS-calculated doses, TLD measurements, and Monte Carlo simulations are generally within 5% in the stack phantom and 10% in the anthropomorphic phantom, with larger variations observed for some of the measurement/calculation points. Dose computation using modeled beams is reasonably accurate, except for regions that include bony anatomy. Inclusion of this dose in treatment plans can lead to more accurate dose prediction, especially when the doses to organs at risk are of importance.

  3. Applications of the Monte Carlo Code Geant to Particle Beam Therapy

    NASA Astrophysics Data System (ADS)

    Szymanowski, H.; Fuchs, T.; Nill, S.; Wilkens, J. J.; Pflugfelder, D.; Oelfke, U.; Glinec, Y.; Faure, J.; Malka, V.

    2006-04-01

    We report on the use of the Monte Carlo simulation code GEANT for two different applications in the field of particle beam therapy. The first application relates to the planning of intensity-modulated proton therapy (IMPT) treatments. An important issue is thereby the accurate prediction of the dose while irradiating complex inhomogeneous patient geometries. We developed an improved method to account for tissue inhomogeneities in pencil beam algorithms. We show that GEANT3 can be successfully used to validate the new model before its integration in our treatment planning system. Another project concerns the investigation of the potential of high-energy particles produced by laser-plasma interactions for radiotherapy. GEANT4 simulations of the dosimetric properties of an experimental laser-accelerated electron beam were performed. They show that this technique may be very attractive for the development of new therapy beam modalities such as very-high energy (170 MeV) electrons.

  4. Energy calibration of energy-resolved photon-counting pixel detectors using laboratory polychromatic x-ray beams

    NASA Astrophysics Data System (ADS)

    Youn, Hanbean; Han, Jong Chul; Kam, Soohwa; Yun, Seungman; Kim, Ho Kyung

    2014-10-01

    Recently, photon-counting detectors capable of resolving incident x-ray photon energies have been considered for use in spectral x-ray imaging applications. For reliable use of energy-resolved photon-counting detectors (ERPCDs), energy calibration is an essential procedure prior to their use because variations in responses from each pixel of the ERPCD for incident photons, even at the same energy, are inevitable. Energy calibration can be performed using a variety of methods. In all of these methods, the photon spectra with well-defined peak energies are recorded. Every pixel should be calibrated on its own. In this study, we suggest the use of a conventional polychromatic x-ray source (that is typically used in laboratories) for energy calibration. The energy calibration procedure mainly includes the determination of the peak energies in the spectra, flood-field irradiation, determination of peak channels, and determination of calibration curves (i.e., the slopes and intercepts of linear polynomials). We applied a calibration algorithm to a CdTe ERPCD comprised of 128×128 pixels with a pitch of 0.35 mm using highly attenuated polychromatic x-ray beams to reduce the pulse pile-up effect, and to obtain a narrow-shaped spectrum due to beam hardening. The averaged relative error in calibration curves obtained from 16,384 pixels was about 0.56% for 59.6 keV photons from an Americium radioisotope. This pixel-by-pixel energy calibration enhanced the signal- and contrast-to-noise ratios in images, respectively, by a factor of ~5 and 3 due to improvement in image homogeneity, compared to those obtained without energy calibration. One secondary finding of this study was that the x-ray photon spectra obtained using a common algorithm for computing x-ray spectra reasonably described the peaks in the measured spectra, which implies easier peak detection without the direct measurement of spectra using a separate spectrometer. The proposed method will be a useful alternative to

  5. Potential clinical impact of laser-accelerated beams in cancer ion therapy

    NASA Astrophysics Data System (ADS)

    Obcemea, Ceferino

    2016-09-01

    In this article, I present three advantages of plasma-accelerated ion beams for cancer therapy. I discuss how: 1. low-emittance and well-collimated beams are advantageous in proximal normal tissue-sparing; 2. highly-peaked quasi-monoenergetic beams are ideal for fast energy selection and switching in Pencil Beam Scanning (PBS) as a treatment delivery; 3. high fluence and ultra-short pulse delivery produce collective excitations in the medium and enhance the stopping power. This in turn produces denser ionization track signatures (spurs, blobs, etc.) in target tumors, higher linear energy transfer, higher Bragg peak, and higher radiobiological effectiveness at the micro-level.

  6. Treatment of cancer of the pancreas by intraoperative electron beam therapy: physical and biological aspects

    SciTech Connect

    Bagne, F.R.; Dobelbower, R.R. Jr.; Milligan, A.J.; Bronn, D.G.

    1989-01-01

    Radiation therapy has had a significant and an expanded role in the management of cancer of the pancreas during the last decade. In particular, for locally advanced disease, radiation therapy has improved the median survival of patients to 1 year. Intraoperative electron beam therapy has been applied to unresectable and resectable pancreatic cancer in an attempt to enhance local control of disease and to improve patient survival. This paper presents a survey of the role of radiation therapy in treatment of cancer of the pancreas, provides information on the radiobiological aspects of this treatment modality and details the physical and dosimetric characteristics of intraoperative radiation therapy with electrons. Presented are the design specifics of an applicator system, central axis beam data, applicator parameters, dose distribution data, shielding, treatment planning and means of verification. Emphasis is placed on the collaboration and cooperation necessary for all members of the intraoperative radiation therapy team including surgeons, radiation therapists, medical physicists, anesthesiologists, technologists, and nurses.29 references.

  7. Reference radiochromic film dosimetry in kilovoltage photon beams during CBCT image acquisition

    SciTech Connect

    Tomic, Nada; Devic, Slobodan; DeBlois, Francois; Seuntjens, Jan

    2010-03-15

    Purpose: A common approach for dose assessment during cone beam computed tomography (CBCT) acquisition is to use thermoluminescent detectors for skin dose measurements (on patients or phantoms) or ionization chamber (in phantoms) for body dose measurements. However, the benefits of a daily CBCT image acquisition such as margin reduction in planning target volume and the image quality must be weighted against the extra dose received during CBCT acquisitions. Methods: The authors describe a two-dimensional reference dosimetry technique for measuring dose from CBCT scans using the on-board imaging system on a Varian Clinac-iX linear accelerator that employs the XR-QA radiochromic film model, specifically designed for dose measurements at low energy photons. The CBCT dose measurements were performed for three different body regions (head and neck, pelvis, and thorax) using humanoid Rando phantom. Results: The authors report on both surface dose and dose profiles measurements during clinical CBCT procedures carried out on a humanoid Rando phantom. Our measurements show that the surface doses per CBCT scan can range anywhere between 0.1 and 4.7 cGy, with the lowest surface dose observed in the head and neck region, while the highest surface dose was observed for the Pelvis spot light CBCT protocol in the pelvic region, on the posterior side of the Rando phantom. The authors also present results of the uncertainty analysis of our XR-QA radiochromic film dosimetry system. Conclusions: Radiochromic film dosimetry protocol described in this work was used to perform dose measurements during CBCT acquisitions with the one-sigma dose measurement uncertainty of up to 3% for doses above 1 cGy. Our protocol is based on film exposure calibration in terms of ''air kerma in air,'' which simplifies both the calibration procedure and reference dosimetry measurements. The results from a full Monte Carlo investigation of the dose conversion of measured XR-QA film dose at the surface into

  8. On-ground calibration of AGILE-GRID with a photon beam: results and lessons for the future

    NASA Astrophysics Data System (ADS)

    Cattaneo, P. W.; Rappoldi, A.

    2013-06-01

    On the AGILE satellite, there is the Gamma Ray Imaging Detector (GRID) consisting of a Silicon Tracker (ST), a Cesium Iodide Mini-Calorimeter and an Anti-Coincidence system of plastic scintillator bars. The ST needs a calibration with a γ-ray beam to validate the simulation used to calculate the detector response versus the energy and the direction of the γ rays. A tagged γ-ray beam line was designed at the Beam Test Facility of the Laboratori Nazionali of Frascati, generated by an electron beam through bremsstrahlung in a position-sensitive target. The γ-ray energy is deduced by the difference with the post-bremsstrahlung electron energy [P. W. Cattaneo, et al., Characterization of a tagged γ-ray beam line at the daΦne beam test facility, Nucl. Instr. and Meth. A 674 (2012) 55-66; P. W. Cattaneo, et al., First results about on-ground calibration of the silicon tracker for the agile satellite, Nucl. Instr. and Meth. A 630(1) (2011) 251-257.]. The electron energy is measured by a spectrometer consisting of a dipole magnet and an array of position sensitive silicon strip detectors, the Photon Tagging System (PTS). In this paper the setup and the calibration of AGILE performed in 2005 are described.

  9. Thermal management and prototype testing of Compton scattering X-ray beam position monitor for the Advanced Photon Source Upgrade

    NASA Astrophysics Data System (ADS)

    Lee, S. H.; Yang, B. X.; Collins, J. T.; Ramanathan, M.

    2017-02-01

    Accurate and stable x-ray beam position monitors (XBPMs) are key elements in obtaining the desired user beam stability in the Advanced Photon Source Upgrade. In the next-generation XBPMs for the canted-undulator front ends, where two undulator beams are separated by 1.0 mrad, the lower beam power (<10 kW) per undulator allows us to explore lower-cost solutions based on Compton scattering from a diamond placed edge-on to the x-ray beam. Because of the high peak power density of the x-ray beams, this diamond experiences high temperatures and has to be clamped to a water-cooled heat spreader using thermal interface materials (TIMs), which play a key role in reducing the temperature of the diamond. To evaluate temperature changes through the interface via thermal simulations, the thermal contact resistance (TCR) of TIMs at an interface between two solid materials under even contact pressure must be known. This paper addresses the TCR measurements of several TIMs, including gold, silver, pyrolytic graphite sheet, and 3D graphene foam. In addition, a prototype of a Compton-scattering XBPM with diamond blades was installed at APS Beamline 24-ID-A in May 2015 and has been tested. This paper presents the design of the Compton-scattering XBPM, and compares thermal simulation results obtained for the diamond blade of this XBPM by the finite element method with in situ empirical measurements obtained by using reliable infrared technology.

  10. Air cavity effects on the radition dose to the larynx using Co-60, 6 MV, and 10 MV photon beams

    SciTech Connect

    Niroomand-Rad, A.; Harter, K.W.; Thobejane, S.; Bertrand, K.

    1994-07-30

    The purpose was to determine the perturbation effect in the surface layers of lesions located in the air-tumor tissues interface of larynx using {sup 60}Co, 6 MV, and 10 MV photon beams. Thermoluminescent dosimeters (TLDs) were embedded at 16 measurement locations in slab no. 8 of a humanoid phantom and exposed to two lateral-opposed beams using standard 7 {times} 7 cm fields. Similarly, radiographic and radiochromic films were placed between slabs no. 7 and no. 8 of the humanoid phantom and exposed to two lateral-opposed radiation beams. The dosimeters were irradiated with {sup 60}Co, 6 MV, and 10 MV photon beams. Computer tomography (CT) treatment planning without inhomogeneity correction was performed. At the tissue-air interface, the average measured percentage dose (% dose{sub m}) is about (108.7 {+-} 4.8%) with TLD data, (96.8 {+-} 2.5%) with radiographic film data, and (100.8 {+-} 4.9%) with radiochromic film data. Similarly, in the central part of the cavity, the % dose{sub m} is (98.4 {+-} 3.1)% with TLD data, (94.3 {+-} 3.3)% with radiographic film data, and (91.7 {+-} 5.0)% with radiochromic film data. Using the CT-based generated dose distribution (without inhomogeneity correction), the average calculated percentage dose (% dose{sub c}) is (98.7 {+-} 1.0%) at the tissue-air interface and 98% in the central part of the air cavity. For the beam energies studied, the variation from the % dose {sub m} at the tissue-air interface for a given dosimetry technique is relatively small and therefore should not be significant in clinical settings. The variation from the % dose{sub m} at the tissue-air interface is more significant for lower energies. This variation is about 4.3% for 10 MV photon beam, therefore, while institutional practice favors lower energy ({sup 60}Co to 6 MV) for node-negative glottic cancers, physical/dosimetric evidence offers no disadvantage to the use of higher energy photons. 10 refs., 7 figs., 2 tabs.

  11. Craniospinal Irradiation Techniques: A Dosimetric Comparison of Proton Beams With Standard and Advanced Photon Radiotherapy

    SciTech Connect

    Yoon, Myonggeun; Shin, Dong Ho; Kim, Jinsung; Kim, Jong Won; Kim, Dae Woong; Park, Sung Yong; Lee, Se Byeong; Kim, Joo Young; Park, Hyeon-Jin; Park, Byung Kiu; Shin, Sang Hoon

    2011-11-01

    Purpose: To evaluate the dosimetric benefits of advanced radiotherapy techniques for craniospinal irradiation in cancer in children. Methods and Materials: Craniospinal irradiation (CSI) using three-dimensional conformal radiotherapy (3D-CRT), tomotherapy (TOMO), and proton beam treatment (PBT) in the scattering mode was planned for each of 10 patients at our institution. Dosimetric benefits and organ-specific radiation-induced cancer risks were based on comparisons of dose-volume histograms (DVHs) and on the application of organ equivalent doses (OEDs), respectively. Results: When we analyzed the organ-at-risk volumes that received 30%, 60%, and 90% of the prescribed dose (PD), we found that PBT was superior to TOMO and 3D-CRT. On average, the doses delivered by PBT to the esophagus, stomach, liver, lung, pancreas, and kidney were 19.4 Gy, 0.6 Gy, 0.3 Gy, 2.5 Gy, 0.2 Gy, and 2.2 Gy for the PD of 36 Gy, respectively, which were significantly lower than the doses delivered by TOMO (22.9 Gy, 4.5 Gy, 6.1 Gy, 4.0 Gy, 13.3 Gy, and 4.9 Gy, respectively) and 3D-CRT (34.6 Gy, 3.6 Gy, 8.0 Gy, 4.6 Gy, 22.9 Gy, and 4.3 Gy, respectively). Although the average doses delivered by PBT to the chest and abdomen were significantly lower than those of 3D-CRT or TOMO, these differences were reduced in the head-and-neck region. OED calculations showed that the risk of secondary cancers in organs such as the stomach, lungs, thyroid, and pancreas was much higher when 3D-CRT or TOMO was used than when PBT was used. Conclusions: Compared with photon techniques, PBT showed improvements in most dosimetric parameters for CSI patients, with lower OEDs to organs at risk.

  12. Accelerator Based Neutron Beams for Neutron Capture Therapy

    SciTech Connect

    Yanch, Jacquelyn C.

    2003-04-11

    The DOE-funded accelerator BNCT program at the Massachusetts Institute of Technology has resulted in the only operating accelerator-based epithermal neutron beam facility capable of generating significant dose rates in the world. With five separate beamlines and two different epithermal neutron beam assemblies installed, we are currently capable of treating patients with rheumatoid arthritis in less than 15 minutes (knee joints) or 4 minutes (finger joints) or irradiating patients with shallow brain tumors to a healthy tissue dose of 12.6 Gy in 3.6 hours. The accelerator, designed by Newton scientific Incorporated, is located in dedicated laboratory space that MIT renovated specifically for this project. The Laboratory for Accelerator Beam Applications consists of an accelerator room, a control room, a shielded radiation vault, and additional laboratory space nearby. In addition to the design, construction and characterization of the tandem electrostatic accelerator, this program also resulted in other significant accomplishments. Assemblies for generating epithermal neutron beams were designed, constructed and experimentally evaluated using mixed-field dosimetry techniques. Strategies for target construction and target cooling were implemented and tested. We demonstrated that the method of submerged jet impingement using water as the coolant is capable of handling power densities of up to 6 x 10(sup 7) W/m(sup 2) with heat transfer coefficients of 10(sup 6)W/m(sup 2)-K. Experiments with the liquid metal gallium demonstrated its superiority compared with water with little effect on the neutronic properties of the epithermal beam. Monoenergetic proton beams generated using the accelerator were used to evaluate proton RBE as a function of LET and demonstrated a maximum RBE at approximately 30-40 keV/um, a finding consistent with results published by other researchers. We also developed an experimental approach to biological intercomparison of epithermal beams and

  13. Verification of the pure alanine in PMMA tube dosimeter applicability for dosimetry of radiotherapy photon beams: a feasibility study.

    PubMed

    Al-Karmi, Anan M; Ayaz, Ali Asghar H; Al-Enezi, Mamdouh S; Abdel-Rahman, Wamied; Dwaikat, Nidal

    2015-09-01

    Alanine dosimeters in the form of pure alanine powder in PMMA plastic tubes were investigated for dosimetry in a clinical application. Electron paramagnetic resonance (EPR) spectroscopy was used to measure absorbed radiation doses by detection of signals from radicals generated in irradiated alanine. The measurements were performed for low-dose ranges typical for single-fraction doses often used in external photon beam radiotherapy. First, the dosimeters were irradiated in a solid water phantom to establish calibration curves in the dose range from 0.3 to 3 Gy for 6 and 18 MV X-ray beams from a clinical linear accelerator. Next, the dosimeters were placed at various locations in an anthropomorphic pelvic phantom to measure the dose delivery of a conventional four-field box technique treatment plan to the pelvis. Finally, the doses measured with alanine dosimeters were compared against the doses calculated with a commercial treatment planning system (TPS). The results showed that the alanine dosimeters have a highly sensitive dose response with good linearity and no energy dependence in the dose range and photon beams used in this work. Also, a fairly good agreement was found between the in-phantom dose measurements with alanine dosimeters and the TPS dose calculations. The mean value of the ratios of measured to calculated dose values was found to be near unity. The measured points in the in-field region passed dose-difference acceptance criterion of 3% and those in the penumbral region passed distance-to-agreement acceptance criterion of 3 mm. These findings suggest that the pure alanine powder in PMMA tube dosimeter is a suitable option for dosimetry of radiotherapy photon beams.

  14. Photon frequency-mode matching using acousto-optic frequency beam splitters

    SciTech Connect