Science.gov

Sample records for phraseology general principles

  1. Itch Management: General Principles.

    PubMed

    Misery, Laurent

    2016-01-01

    Like pain, itch is a challenging condition that needs to be managed. Within this setting, the first principle of itch management is to get an appropriate diagnosis to perform an etiology-oriented therapy. In several cases it is not possible to treat the cause, the etiology is undetermined, there are several causes, or the etiological treatment is not effective enough to alleviate itch completely. This is also why there is need for symptomatic treatment. In all patients, psychological support and associated pragmatic measures might be helpful. General principles and guidelines are required, yet patient-centered individual care remains fundamental. PMID:27578069

  2. Itch Management: General Principles.

    PubMed

    Misery, Laurent

    2016-01-01

    Like pain, itch is a challenging condition that needs to be managed. Within this setting, the first principle of itch management is to get an appropriate diagnosis to perform an etiology-oriented therapy. In several cases it is not possible to treat the cause, the etiology is undetermined, there are several causes, or the etiological treatment is not effective enough to alleviate itch completely. This is also why there is need for symptomatic treatment. In all patients, psychological support and associated pragmatic measures might be helpful. General principles and guidelines are required, yet patient-centered individual care remains fundamental.

  3. Archimedes' Principle in General Coordinates

    ERIC Educational Resources Information Center

    Ridgely, Charles T.

    2010-01-01

    Archimedes' principle is well known to state that a body submerged in a fluid is buoyed up by a force equal to the weight of the fluid displaced by the body. Herein, Archimedes' principle is derived from first principles by using conservation of the stress-energy-momentum tensor in general coordinates. The resulting expression for the force is…

  4. Teaching professionalism: general principles.

    PubMed

    Cruess, Richard L; Cruess, Sylvia R

    2006-05-01

    There are educational principles that apply to the teaching of professionalism during undergraduate education and postgraduate training. It is axiomatic that there is a single cognitive base that applies with increasing moral force as students enter medical school, progress to residency or registrar training, and enter practice. While parts of this body of knowledge are easier to teach and learn at different stages of an individual's career, it remains a definable whole at all times and should be taught as such. While the principle that self-reflection on theoretical and real issues encountered in the life of a student, resident or practitioner is essential to the acquisition of experiential learning and the incorporation of the values and behaviors of the professional, the opportunities to provide situations where this can take place will change as an individual progresses through the system, as will the sophistication of the level of learning. Teaching the cognitive base of professionalism and providing opportunities for the internalization of its values and behaviors are the cornerstones of the organization of the teaching of professionalism at all levels. Situated learning theory appears to provide practical guidance as to how this may be implemented. While the application of this theory will vary with the type of curriculum, the institutional culture and the resources available, the principles outlined should remain constant.

  5. The Principle of General Tovariance

    NASA Astrophysics Data System (ADS)

    Heunen, C.; Landsman, N. P.; Spitters, B.

    2008-06-01

    We tentatively propose two guiding principles for the construction of theories of physics, which should be satisfied by a possible future theory of quantum gravity. These principles are inspired by those that led Einstein to his theory of general relativity, viz. his principle of general covariance and his equivalence principle, as well as by the two mysterious dogmas of Bohr's interpretation of quantum mechanics, i.e. his doctrine of classical concepts and his principle of complementarity. An appropriate mathematical language for combining these ideas is topos theory, a framework earlier proposed for physics by Isham and collaborators. Our principle of general tovariance states that any mathematical structure appearing in the laws of physics must be definable in an arbitrary topos (with natural numbers object) and must be preserved under so-called geometric morphisms. This principle identifies geometric logic as the mathematical language of physics and restricts the constructions and theorems to those valid in intuitionism: neither Aristotle's principle of the excluded third nor Zermelo's Axiom of Choice may be invoked. Subsequently, our equivalence principle states that any algebra of observables (initially defined in the topos Sets) is empirically equivalent to a commutative one in some other topos.

  6. Archimedes' principle in general coordinates

    NASA Astrophysics Data System (ADS)

    Ridgely, Charles T.

    2010-05-01

    Archimedes' principle is well known to state that a body submerged in a fluid is buoyed up by a force equal to the weight of the fluid displaced by the body. Herein, Archimedes' principle is derived from first principles by using conservation of the stress-energy-momentum tensor in general coordinates. The resulting expression for the force is applied in Schwarzschild coordinates and in rotating coordinates. Using Schwarzschild coordinates for the case of a spherical mass suspended within a perfect fluid leads to the familiar expression of Archimedes' principle. Using rotating coordinates produces an expression for a centrifugal buoyancy force that agrees with accepted theory. It is then argued that Archimedes' principle ought to be applicable to non-gravitational phenomena, as well. Conservation of the energy-momentum tensor is then applied to electromagnetic phenomena. It is shown that a charged body submerged in a charged medium experiences a buoyancy force in accordance with an electromagnetic analogue of Archimedes' principle.

  7. General principles of antimicrobial therapy.

    PubMed

    Leekha, Surbhi; Terrell, Christine L; Edson, Randall S

    2011-02-01

    Antimicrobial agents are some of the most widely, and often injudiciously, used therapeutic drugs worldwide. Important considerations when prescribing antimicrobial therapy include obtaining an accurate diagnosis of infection; understanding the difference between empiric and definitive therapy; identifying opportunities to switch to narrow-spectrum, cost-effective oral agents for the shortest duration necessary; understanding drug characteristics that are peculiar to antimicrobial agents (such as pharmacodynamics and efficacy at the site of infection); accounting for host characteristics that influence antimicrobial activity; and in turn, recognizing the adverse effects of antimicrobial agents on the host. It is also important to understand the importance of antimicrobial stewardship, to know when to consult infectious disease specialists for guidance, and to be able to identify situations when antimicrobial therapy is not needed. By following these general principles, all practicing physicians should be able to use antimicrobial agents in a responsible manner that benefits both the individual patient and the community.

  8. General principles of antimicrobial therapy.

    PubMed

    Leekha, Surbhi; Terrell, Christine L; Edson, Randall S

    2011-02-01

    Antimicrobial agents are some of the most widely, and often injudiciously, used therapeutic drugs worldwide. Important considerations when prescribing antimicrobial therapy include obtaining an accurate diagnosis of infection; understanding the difference between empiric and definitive therapy; identifying opportunities to switch to narrow-spectrum, cost-effective oral agents for the shortest duration necessary; understanding drug characteristics that are peculiar to antimicrobial agents (such as pharmacodynamics and efficacy at the site of infection); accounting for host characteristics that influence antimicrobial activity; and in turn, recognizing the adverse effects of antimicrobial agents on the host. It is also important to understand the importance of antimicrobial stewardship, to know when to consult infectious disease specialists for guidance, and to be able to identify situations when antimicrobial therapy is not needed. By following these general principles, all practicing physicians should be able to use antimicrobial agents in a responsible manner that benefits both the individual patient and the community. PMID:21282489

  9. 21 CFR 102.5 - General principles.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false General principles. 102.5 Section 102.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION COMMON OR USUAL NAME FOR NONSTANDARDIZED FOODS General Provisions § 102.5 General principles....

  10. Quantum mechanics and the generalized uncertainty principle

    SciTech Connect

    Bang, Jang Young; Berger, Micheal S.

    2006-12-15

    The generalized uncertainty principle has been described as a general consequence of incorporating a minimal length from a theory of quantum gravity. We consider a simple quantum mechanical model where the operator corresponding to position has discrete eigenvalues and show how the generalized uncertainty principle results for minimum uncertainty wave packets.

  11. 5 CFR 551.202 - General principles.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false General principles. 551.202 Section 551.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION UNDER THE FAIR LABOR STANDARDS ACT Exemptions and Exclusions § 551.202 General principles. In...

  12. 5 CFR 551.202 - General principles.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false General principles. 551.202 Section 551.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION UNDER THE FAIR LABOR STANDARDS ACT Exemptions and Exclusions § 551.202 General principles. In...

  13. 5 CFR 551.202 - General principles.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false General principles. 551.202 Section 551.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION UNDER THE FAIR LABOR STANDARDS ACT Exemptions and Exclusions § 551.202 General principles. In...

  14. 5 CFR 551.202 - General principles.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false General principles. 551.202 Section 551.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION UNDER THE FAIR LABOR STANDARDS ACT Exemptions and Exclusions § 551.202 General principles. In...

  15. Deriving and applying generally applicable safety principles

    SciTech Connect

    Spray, S.D.

    1998-08-01

    The nuclear detonation safety of modern nuclear weapons depends on a coordinated safety theme incorporating three general safety principles: isolation, inoperability, and incompatibility. The success of this approach has encouraged them to study whether these and/or other principles might be useful in other applications. Not surprisingly, no additional first-principles (based on physical laws) have been identified. However, a more widely applicable definition and application of the principle-based approach has been developed, resulting in a selection of strategies that are basically subsets and varied combinations of the more general principles above. However, identification of principles to be relied on is only one step in providing a safe design. As one other important example, coordinating overall architecture and strategy is essential: the authors term this a safety theme.

  16. Space flight operations communications phraseology and techniques

    NASA Technical Reports Server (NTRS)

    Noneman, S. R.

    1986-01-01

    Communications are a critical link in space flight operations. Specific communications phraseology and techniques have been developed to allow rapid and clear transfer of information. Communications will be clear and brief through the use of procedural words and phrases. Communications protocols standardize the required information transferred. The voicing of letters and numbers is discussed. The protocols used in air-to-ground communications are given. A glossary of communications terminology is presented in the appendix.

  17. Action principle for the generalized harmonic formulation of general relativity

    SciTech Connect

    Brown, J. David

    2011-10-15

    An action principle for the generalized harmonic formulation of general relativity is presented. The action is a functional of the spacetime metric and the gauge source vector. An action principle for the Z4 formulation of general relativity has been proposed recently by Bona, Bona-Casas, and Palenzuela. The relationship between the generalized harmonic action and the Bona, Bona-Casas, and Palenzuela action is discussed in detail.

  18. 29 CFR 1604.1 - General principles.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false General principles. 1604.1 Section 1604.1 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION GUIDELINES ON DISCRIMINATION BECAUSE... state principles that are applicable not only to employers but also to labor organizations and...

  19. 29 CFR 1604.1 - General principles.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 4 2011-07-01 2011-07-01 false General principles. 1604.1 Section 1604.1 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION GUIDELINES ON DISCRIMINATION BECAUSE... state principles that are applicable not only to employers but also to labor organizations and...

  20. 31 CFR 29.321 - General principle.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... CERTAIN DISTRICT OF COLUMBIA RETIREMENT PROGRAMS Split Benefits Service Performed After June 30, 1997 § 29.321 General principle. Any service performed after June 30, 1997, may never be credited toward...

  1. 21 CFR 104.5 - General principles.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... on the label or in labeling representing, suggesting, or implying any nutritional or other... CONSUMPTION NUTRITIONAL QUALITY GUIDELINES FOR FOODS General Provisions § 104.5 General principles. (a) A nutritional quality guideline prescribes the minimum level or range of nutrient composition...

  2. Pure connection action principle for general relativity.

    PubMed

    Krasnov, Kirill

    2011-06-24

    It has already been known for two decades that general relativity can be reformulated as a certain gauge theory, so that the only dynamical field is an SO(3) connection and the spacetime metric appears as a derived object. However, no simple action principle realizing these ideas has been available. A new elegant action principle for such a "pure connection" formulation of GR is described.

  3. 39 CFR 268.1 - General principles.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... OF CONDUCT § 268.1 General principles. In order to conduct its business, the Postal Service has the... handling it have a legal and ethical obligation to hold it in confidence and to actively protect it from... collected, maintained and used for official Postal Service business. Employees shall be held responsible...

  4. 39 CFR 268.1 - General principles.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... OF CONDUCT § 268.1 General principles. In order to conduct its business, the Postal Service has the... handling it have a legal and ethical obligation to hold it in confidence and to actively protect it from... collected, maintained and used for official Postal Service business. Employees shall be held responsible...

  5. 23 CFR 660.509 - General principles.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 23 Highways 1 2012-04-01 2012-04-01 false General principles. 660.509 Section 660.509 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS SPECIAL... permanent defense installations as they do for highways serving private industrial establishments or...

  6. 5 CFR 551.202 - General principles.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false General principles. 551.202 Section 551.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY... preclude exemption under another category. For example, an engineering technician who fails to meet...

  7. 21 CFR 104.5 - General principles.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false General principles. 104.5 Section 104.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... product shall bear nutrition labeling in accordance with §§ 101.2 and 101.9 of this chapter and all...

  8. 21 CFR 104.5 - General principles.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false General principles. 104.5 Section 104.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... product shall bear nutrition labeling in accordance with §§ 101.2 and 101.9 of this chapter and all...

  9. Teaching General Principles and Applications of Dendrogeomorphology.

    ERIC Educational Resources Information Center

    Butler, David R.

    1987-01-01

    Tree-ring analysis in geomorphology can be incorporated into a number of undergraduate methods in order to reconstruct the history of a variety of geomorphic processes. Discusses dendrochronology, general principles of dendrogeomorphology, field sampling methods, laboratory techniques, and examples of applications. (TW)

  10. 20 CFR 401.140 - General principles.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false General principles. 401.140 Section 401.140 Employees' Benefits SOCIAL SECURITY ADMINISTRATION PRIVACY AND DISCLOSURE OF OFFICIAL RECORDS AND...) The public interest in the disclosure; (c) The rights and expectations of individuals to have...

  11. 20 CFR 401.140 - General principles.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false General principles. 401.140 Section 401.140 Employees' Benefits SOCIAL SECURITY ADMINISTRATION PRIVACY AND DISCLOSURE OF OFFICIAL RECORDS AND...) The public interest in the disclosure; (c) The rights and expectations of individuals to have...

  12. 20 CFR 401.140 - General principles.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false General principles. 401.140 Section 401.140 Employees' Benefits SOCIAL SECURITY ADMINISTRATION PRIVACY AND DISCLOSURE OF OFFICIAL RECORDS AND...) The public interest in the disclosure; (c) The rights and expectations of individuals to have...

  13. 20 CFR 401.140 - General principles.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false General principles. 401.140 Section 401.140 Employees' Benefits SOCIAL SECURITY ADMINISTRATION PRIVACY AND DISCLOSURE OF OFFICIAL RECORDS AND...) The public interest in the disclosure; (c) The rights and expectations of individuals to have...

  14. 18 CFR 358.2 - General principles.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false General principles. 358.2 Section 358.2 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY STANDARDS OF CONDUCT FOR TRANSMISSION PROVIDERS STANDARDS OF CONDUCT § 358.2...

  15. 18 CFR 358.2 - General principles.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false General principles. 358.2 Section 358.2 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY STANDARDS OF CONDUCT FOR TRANSMISSION PROVIDERS STANDARDS OF CONDUCT § 358.2...

  16. 18 CFR 358.2 - General principles.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false General principles. 358.2 Section 358.2 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY STANDARDS OF CONDUCT FOR TRANSMISSION PROVIDERS STANDARDS OF CONDUCT § 358.2...

  17. General Quantum Interference Principle and Duality Computer

    NASA Astrophysics Data System (ADS)

    Long, Gui-Lu

    2006-05-01

    In this article, we propose a general principle of quantum interference for quantum system, and based on this we propose a new type of computing machine, the duality computer, that may outperform in principle both classical computer and the quantum computer. According to the general principle of quantum interference, the very essence of quantum interference is the interference of the sub-waves of the quantum system itself. A quantum system considered here can be any quantum system: a single microscopic particle, a composite quantum system such as an atom or a molecule, or a loose collection of a few quantum objects such as two independent photons. In the duality computer, the wave of the duality computer is split into several sub-waves and they pass through different routes, where different computing gate operations are performed. These sub-waves are then re-combined to interfere to give the computational results. The quantum computer, however, has only used the particle nature of quantum object. In a duality computer, it may be possible to find a marked item from an unsorted database using only a single query, and all NP-complete problems may have polynomial algorithms. Two proof-of-the-principle designs of the duality computer are presented: the giant molecule scheme and the nonlinear quantum optics scheme. We also propose thought experiment to check the related fundamental issues, the measurement efficiency of a partial wave function.

  18. Postoperative infections: general principles and considerations.

    PubMed

    Downey, M S; Lamy, C J

    1990-07-01

    Every surgeon should have a thorough knowledge and awareness of the general principles of postoperative infections. The key to postoperative infections is in their prevention. Even with the most prudent and ardent regimens, however, postoperative wound infections will occasionally occur. Thus, the aforementioned knowledge will allow an improved clinical acumen and permit the early diagnosis of postoperative infection. Early and vigorous local wound care combined with systemic antibiotics are necessary to minimize the potentially debilitating sequelae of the postoperative wound infection.

  19. Lorentz invariance violation and generalized uncertainty principle

    NASA Astrophysics Data System (ADS)

    Tawfik, Abdel Nasser; Magdy, H.; Ali, A. Farag

    2016-01-01

    There are several theoretical indications that the quantum gravity approaches may have predictions for a minimal measurable length, and a maximal observable momentum and throughout a generalization for Heisenberg uncertainty principle. The generalized uncertainty principle (GUP) is based on a momentum-dependent modification in the standard dispersion relation which is conjectured to violate the principle of Lorentz invariance. From the resulting Hamiltonian, the velocity and time of flight of relativistic distant particles at Planck energy can be derived. A first comparison is made with recent observations for Hubble parameter in redshift-dependence in early-type galaxies. We find that LIV has two types of contributions to the time of flight delay Δ t comparable with that observations. Although the wrong OPERA measurement on faster-than-light muon neutrino anomaly, Δ t, and the relative change in the speed of muon neutrino Δ v in dependence on redshift z turn to be wrong, we utilize its main features to estimate Δ v. Accordingly, the results could not be interpreted as LIV. A third comparison is made with the ultra high-energy cosmic rays (UHECR). It is found that an essential ingredient of the approach combining string theory, loop quantum gravity, black hole physics and doubly spacial relativity and the one assuming a perturbative departure from exact Lorentz invariance. Fixing the sensitivity factor and its energy dependence are essential inputs for a reliable confronting of our calculations to UHECR. The sensitivity factor is related to the special time of flight delay and the time structure of the signal. Furthermore, the upper and lower bounds to the parameter, a that characterizes the generalized uncertainly principle, have to be fixed in related physical systems such as the gamma rays bursts.

  20. Sedimentation equilibrium and the generalized Archimedes' principle.

    PubMed

    Parola, Alberto; Buzzaccaro, Stefano; Secchi, Eleonora; Piazza, Roberto

    2013-03-21

    The buoyancy concept is critically re-examined for applications to dispersions of nano-particles, such as colloids, proteins, or macromolecules. It is shown that when the size of the buoyant particle is not too different (say, at most a factor of ten) from the size of the dispersed particles, new intriguing phenomena emerge, leading to the violation of the Archimedes' principle. The resulting buoyancy force depends not only on the volume of the particle and on the mass density of the dispersion, but also on the relative size of the particles, on their geometry, and on the interactions between the buoyant particle and the fluid. Explicit expressions for such a generalized Archimedes' principle are obtained and the results are tested against targeted experiments in colloidal dispersions.

  1. A review of the generalized uncertainty principle.

    PubMed

    Tawfik, Abdel Nasser; Diab, Abdel Magied

    2015-12-01

    Based on string theory, black hole physics, doubly special relativity and some 'thought' experiments, minimal distance and/or maximum momentum are proposed. As alternatives to the generalized uncertainty principle (GUP), the modified dispersion relation, the space noncommutativity, the Lorentz invariance violation, and the quantum-gravity-induced birefringence effects are summarized. The origin of minimal measurable quantities and the different GUP approaches are reviewed and the corresponding observations are analysed. Bounds on the GUP parameter are discussed and implemented in the understanding of recent PLANCK observations of cosmic inflation. The higher-order GUP approaches predict minimal length uncertainty with and without maximum momenta. Possible arguments against the GUP are discussed; for instance, the concern about its compatibility with the equivalence principles, the universality of gravitational redshift and the free fall and law of reciprocal action are addressed. PMID:26512022

  2. A review of the generalized uncertainty principle

    NASA Astrophysics Data System (ADS)

    Nasser Tawfik, Abdel; Magied Diab, Abdel

    2015-12-01

    Based on string theory, black hole physics, doubly special relativity and some ‘thought’ experiments, minimal distance and/or maximum momentum are proposed. As alternatives to the generalized uncertainty principle (GUP), the modified dispersion relation, the space noncommutativity, the Lorentz invariance violation, and the quantum-gravity-induced birefringence effects are summarized. The origin of minimal measurable quantities and the different GUP approaches are reviewed and the corresponding observations are analysed. Bounds on the GUP parameter are discussed and implemented in the understanding of recent PLANCK observations of cosmic inflation. The higher-order GUP approaches predict minimal length uncertainty with and without maximum momenta. Possible arguments against the GUP are discussed; for instance, the concern about its compatibility with the equivalence principles, the universality of gravitational redshift and the free fall and law of reciprocal action are addressed.

  3. A review of the generalized uncertainty principle.

    PubMed

    Tawfik, Abdel Nasser; Diab, Abdel Magied

    2015-12-01

    Based on string theory, black hole physics, doubly special relativity and some 'thought' experiments, minimal distance and/or maximum momentum are proposed. As alternatives to the generalized uncertainty principle (GUP), the modified dispersion relation, the space noncommutativity, the Lorentz invariance violation, and the quantum-gravity-induced birefringence effects are summarized. The origin of minimal measurable quantities and the different GUP approaches are reviewed and the corresponding observations are analysed. Bounds on the GUP parameter are discussed and implemented in the understanding of recent PLANCK observations of cosmic inflation. The higher-order GUP approaches predict minimal length uncertainty with and without maximum momenta. Possible arguments against the GUP are discussed; for instance, the concern about its compatibility with the equivalence principles, the universality of gravitational redshift and the free fall and law of reciprocal action are addressed.

  4. Sedimentation equilibrium and the generalized Archimedes' principle

    NASA Astrophysics Data System (ADS)

    Parola, Alberto; Buzzaccaro, Stefano; Secchi, Eleonora; Piazza, Roberto

    2013-03-01

    The buoyancy concept is critically re-examined for applications to dispersions of nano-particles, such as colloids, proteins, or macromolecules. It is shown that when the size of the buoyant particle is not too different (say, at most a factor of ten) from the size of the dispersed particles, new intriguing phenomena emerge, leading to the violation of the Archimedes' principle. The resulting buoyancy force depends not only on the volume of the particle and on the mass density of the dispersion, but also on the relative size of the particles, on their geometry, and on the interactions between the buoyant particle and the fluid. Explicit expressions for such a generalized Archimedes' principle are obtained and the results are tested against targeted experiments in colloidal dispersions.

  5. Sedimentation equilibrium and the generalized Archimedes' principle.

    PubMed

    Parola, Alberto; Buzzaccaro, Stefano; Secchi, Eleonora; Piazza, Roberto

    2013-03-21

    The buoyancy concept is critically re-examined for applications to dispersions of nano-particles, such as colloids, proteins, or macromolecules. It is shown that when the size of the buoyant particle is not too different (say, at most a factor of ten) from the size of the dispersed particles, new intriguing phenomena emerge, leading to the violation of the Archimedes' principle. The resulting buoyancy force depends not only on the volume of the particle and on the mass density of the dispersion, but also on the relative size of the particles, on their geometry, and on the interactions between the buoyant particle and the fluid. Explicit expressions for such a generalized Archimedes' principle are obtained and the results are tested against targeted experiments in colloidal dispersions. PMID:23534662

  6. Dilaton cosmology, noncommutativity, and generalized uncertainty principle

    SciTech Connect

    Vakili, Babak

    2008-02-15

    The effects of noncommutativity and of the existence of a minimal length on the phase space of a dilatonic cosmological model are investigated. The existence of a minimum length results in the generalized uncertainty principle (GUP), which is a deformed Heisenberg algebra between the minisuperspace variables and their momenta operators. I extend these deformed commutating relations to the corresponding deformed Poisson algebra. For an exponential dilaton potential, the exact classical and quantum solutions in the commutative and noncommutative cases, and some approximate analytical solutions in the case of GUP, are presented and compared.

  7. 14 CFR Sec. 2-1 - Generally accepted accounting principles.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Generally accepted accounting principles... AIR CARRIERS General Accounting Provisions Sec. 2-1 Generally accepted accounting principles. (a) The accounting provisions contained in this part are based on generally accepted accounting principles...

  8. General principles of antibiotic resistance in bacteria.

    PubMed

    Martinez, Jose L

    2014-03-01

    Given the impact of antibiotic resistance on human health, its study is of great interest from a clinical view- point. In addition, antibiotic resistance is one of the few examples of evolution that can be studied in real time. Knowing the general principles involved in the acquisition of antibiotic resistance is therefore of interest to clinicians, evolutionary biologists and ecologists. The origin of antibiotic resistance genes now possessed by human pathogens can be traced back to environmental microorganisms. Consequently, a full understanding of the evolution of antibiotic resistance requires the study of natural environments as well as clinical ecosystems. Updated information on the evolutionary mechanisms behind resistance, indicates that ecological connectivity, founder effect and fitness costs are important bottle- necks that modulate the transfer of resistance from environmental microorganisms to pathogens. PMID:24847651

  9. Generalized uncertainty principle and black hole thermodynamics

    NASA Astrophysics Data System (ADS)

    Gangopadhyay, Sunandan; Dutta, Abhijit; Saha, Anirban

    2014-02-01

    We study the Schwarzschild and Reissner-Nordström black hole thermodynamics using the simplest form of the generalized uncertainty principle (GUP) proposed in the literature. The expressions for the mass-temperature relation, heat capacity and entropy are obtained in both cases from which the critical and remnant masses are computed. Our results are exact and reveal that these masses are identical and larger than the so called singular mass for which the thermodynamics quantities become ill-defined. The expression for the entropy reveals the well known area theorem in terms of the horizon area in both cases upto leading order corrections from GUP. The area theorem written in terms of a new variable which can be interpreted as the reduced horizon area arises only when the computation is carried out to the next higher order correction from GUP.

  10. Rowlands' Duality Principle: A Generalization of Noether's Theorem?

    NASA Astrophysics Data System (ADS)

    Karam, Sabah E.

    This paper will examine a physical principle that has been used in making valid predictions and generalizes established conservation laws. In a previous paper it was shown how Rowlands' zero-totality condition could be viewed as a generalization of Newton's third law of motion. In this paper it will be argued that Rowlands' Duality Principle is a generalization of Noether's Theorem and that the two principles taken together are truly foundational principles that have tamed Metaphysics.

  11. Action principle combining electromagnetism and general relativity

    SciTech Connect

    Moyer, H.G.

    1987-03-01

    The stationary action problem for a single, classical, point particle in external gravitational and electromagnetic fields is written in optimal control format. The relativistic interval is the independent variable and time, space, and action are the five dependent variables. A general metric is used for the space-time manifold so that the equations are manifestly covariant. The form of the system equations guarantees that the particle moves with unit speed with respect to interval. The Lagrangian is a function of the metric tensor and the electromagnetic four-potential, but not of particle parameters such as electric charge q and mass m. The Hamiltonian is not identically zero, unlike those derived in many earlier analyses. A constant of the motion is found that is identified with q/mc/sup 2/. An explanation is presented for the classical inequality mgreater than or equal to0. The trajectories can reduce to geodesics and even further to those governed by Fermat's principle of stationary time.

  12. Principle of least action; some possible generalizations

    SciTech Connect

    Broucke, R.

    1982-08-01

    In this article we draw the attention to an important variational principle in dynamics: the Maupertuis-Jacobi Least Action Principle (MJLAP). This principle compares varied paths with the same energy h. We give two new proofs of the MJLAP (Sections 3 and 8) as well as a new unified variational principle which contains both Hamilton's Principle (HP) and the MJLAP as particular cases (Sections 4 and 9). The article also shows several new methods for the construction of a Lagrangian for a conservative dynamical system. As an example, we illustrate the theory with the classical Harmonic Oscillator Problem (Section 10). Our method is based on the theory of changes of independent variables in a dynamical system. It indirectly shows how a change of independent variable affects the self-adjointness of a dynamical system (Sections 5, 6, 7). Our new Lagrangians contain an arbitrary constant ..cap alpha.., whose meaning needs to be studied, eventually in relation to the concepts of quantification or gauge transformations. The two important values of the constant ..cap alpha.. are 1 (Hamilton's principle) and 1/2 (Maupertuis-Jacobi Least Action Principle).

  13. Incorporation of generalized uncertainty principle into Lifshitz field theories

    SciTech Connect

    Faizal, Mir; Majumder, Barun

    2015-06-15

    In this paper, we will incorporate the generalized uncertainty principle into field theories with Lifshitz scaling. We will first construct both bosonic and fermionic theories with Lifshitz scaling based on generalized uncertainty principle. After that we will incorporate the generalized uncertainty principle into a non-abelian gauge theory with Lifshitz scaling. We will observe that even though the action for this theory is non-local, it is invariant under local gauge transformations. We will also perform the stochastic quantization of this Lifshitz fermionic theory based generalized uncertainty principle.

  14. Obscie osnovy pedagogiki (General Principles of Pedagogics).

    ERIC Educational Resources Information Center

    Korelev, F. F., Ed.; Gmurman, V. E., Ed.

    This document is an English-language abstract (approximately 1,500 words) of a book that forms part of a series of monographs compiled by the Principles of Pedagogy Section of the Institute of the Theory and History of Pedagogy of the Academy of Pedagogical Sciences of the USSR. It gives a comprehensive picture of the history, main categories,…

  15. 43 CFR 2.37 - What general principles govern fees?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false What general principles govern fees? 2.37 Section 2.37 Public Lands: Interior Office of the Secretary of the Interior FREEDOM OF INFORMATION ACT; RECORDS AND TESTIMONY Fees § 2.37 What general principles govern fees? (a) The bureau will charge...

  16. 43 CFR 2.37 - What general principles govern fees?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false What general principles govern fees? 2.37 Section 2.37 Public Lands: Interior Office of the Secretary of the Interior FREEDOM OF INFORMATION ACT; RECORDS AND TESTIMONY Fees § 2.37 What general principles govern fees? (a) The bureau will charge...

  17. 34 CFR 76.530 - General cost principles.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false General cost principles. 76.530 Section 76.530 Education Office of the Secretary, Department of Education STATE-ADMINISTERED PROGRAMS What Conditions Must... CFR 74.27 and 34 CFR 80.22 reference the general cost principles that apply to grants, subgrants...

  18. 29 CFR 2.11 - General principles.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Secretary of Labor GENERAL REGULATIONS Audiovisual Coverage of Administrative Hearings § 2.11 General... involve administrative hearings. If such administrative hearings are held, we encourage their audiovisual coverage. (b) Audiovisual coverage shall be excluded in adjudicatory proceedings involving the rights...

  19. Dose reduction in paediatric MDCT: general principles.

    PubMed

    Paterson, A; Frush, D P

    2007-06-01

    The number of multi-detector array computed tomography (MDCT) examinations performed per annum continues to increase in both the adult and paediatric populations. Estimates from 2003 suggested that CT contributed 17% of a radiology department's workload, yet was responsible for up to 75% of the collective population dose from medical radiation. The effective doses for some CT examinations today overlap with those argued to have an increased risk of cancer. This is especially pertinent for paediatric CT, as children are more radiosensitive than adults (and girls more radiosensitive than boys). In addition, children have a longer life ahead of them, in which radiation induced cancers may become manifest. Radiologists must be aware of these facts and practise the ALARA (as low as is reasonably achievable) principle, when it comes to deciding CT protocols and parameters. PMID:17467387

  20. 12 CFR 330.3 - General principles.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY DEPOSIT.... The availability of deposit insurance is not limited to citizens and residents of the United States... deposit insurance provided by the Act and this part. In addition, deposits denominated in a...

  1. 12 CFR 330.3 - General principles.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY DEPOSIT.... The availability of deposit insurance is not limited to citizens and residents of the United States... deposit insurance provided by the Act and this part. In addition, deposits denominated in a...

  2. 21 CFR 101.13 - general principles.

    Code of Federal Regulations, 2012 CFR

    1996-04-01

    ... content claims FOOD AND DRUGS FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES--CONTINUED FOOD FOR HUMAN CONSUMPTION FOOD LABELING General Provisions Sec. 101.13 Nutrient content claims... supplements). (b) A claim that expressly or implicitly characterizes the level of a nutrient (nutrient...

  3. 43 CFR 24.3 - General jurisdictional principles.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... enactment of Federal fish and wildlife conservation statutes has generally been associated with the... FISH AND WILDLIFE POLICY: STATE-FEDERAL RELATIONSHIPS § 24.3 General jurisdictional principles. (a) In general the States possess broad trustee and police powers over fish and wildlife within their...

  4. 43 CFR 24.3 - General jurisdictional principles.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... enactment of Federal fish and wildlife conservation statutes has generally been associated with the... FISH AND WILDLIFE POLICY: STATE-FEDERAL RELATIONSHIPS § 24.3 General jurisdictional principles. (a) In general the States possess broad trustee and police powers over fish and wildlife within their...

  5. 43 CFR 24.3 - General jurisdictional principles.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... enactment of Federal fish and wildlife conservation statutes has generally been associated with the... FISH AND WILDLIFE POLICY: STATE-FEDERAL RELATIONSHIPS § 24.3 General jurisdictional principles. (a) In general the States possess broad trustee and police powers over fish and wildlife within their...

  6. 43 CFR 24.3 - General jurisdictional principles.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... enactment of Federal fish and wildlife conservation statutes has generally been associated with the... FISH AND WILDLIFE POLICY: STATE-FEDERAL RELATIONSHIPS § 24.3 General jurisdictional principles. (a) In general the States possess broad trustee and police powers over fish and wildlife within their...

  7. 43 CFR 24.3 - General jurisdictional principles.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... enactment of Federal fish and wildlife conservation statutes has generally been associated with the... FISH AND WILDLIFE POLICY: STATE-FEDERAL RELATIONSHIPS § 24.3 General jurisdictional principles. (a) In general the States possess broad trustee and police powers over fish and wildlife within their...

  8. Generalized principles of unchanging total concentration.

    PubMed

    Kottke, Peter A; Fedorov, Andrei G

    2005-09-01

    We consider the transport of multiple reacting species under the continuum assumption in situations such as those that frequently arise in electroanalytical chemistry. Under certain limitations, it has been shown that the total species concentration (as defined by Oldham and Feldberg) of such a system is uniform and constant. In this work, we extend the limits of the previous analysis to enable greater applicability. This is accomplished by using either of two new dependent variables, which are generalizations of the concept of total concentration. Then, conditions are determined under which the dependent variable will be uniform and constant in time. From a practical viewpoint, the described formalism allows one to simplify the multispecies transport problem formulation by eliminating one equation from the system of governing equations.

  9. Gauge theories under incorporation of a generalized uncertainty principle

    SciTech Connect

    Kober, Martin

    2010-10-15

    There is considered an extension of gauge theories according to the assumption of a generalized uncertainty principle which implies a minimal length scale. A modification of the usual uncertainty principle implies an extended shape of matter field equations like the Dirac equation. If there is postulated invariance of such a generalized field equation under local gauge transformations, the usual covariant derivative containing the gauge potential has to be replaced by a generalized covariant derivative. This leads to a generalized interaction between the matter field and the gauge field as well as to an additional self-interaction of the gauge field. Since the existence of a minimal length scale seems to be a necessary assumption of any consistent quantum theory of gravity, the gauge principle is a constitutive ingredient of the standard model, and even gravity can be described as gauge theory of local translations or Lorentz transformations, the presented extension of gauge theories appears as a very important consideration.

  10. A generalization of Fermat's principle for classical and quantum systems

    NASA Astrophysics Data System (ADS)

    Elsayed, Tarek A.

    2014-09-01

    The analogy between dynamics and optics had a great influence on the development of the foundations of classical and quantum mechanics. We take this analogy one step further and investigate the validity of Fermat's principle in many-dimensional spaces describing dynamical systems (i.e., the quantum Hilbert space and the classical phase and configuration space). We propose that if the notion of a metric distance is well defined in that space and the velocity of the representative point of the system is an invariant of motion, then a generalized version of Fermat's principle will hold. We substantiate this conjecture for time-independent quantum systems and for a classical system consisting of coupled harmonic oscillators. An exception to this principle is the configuration space of a charged particle in a constant magnetic field; in this case the principle is valid in a frame rotating by half the Larmor frequency, not the stationary lab frame.

  11. Fluorescent-protein-based probes: general principles and practices.

    PubMed

    Ai, Hui-Wang

    2015-01-01

    An important application of fluorescent proteins is to derive genetically encoded fluorescent probes that can actively respond to cellular dynamics such as pH change, redox signaling, calcium oscillation, enzyme activities, and membrane potential. Despite the large diverse group of fluorescent-protein-based probes, a few basic principles have been established and are shared by most of these probes. In this article, the focus is on these general principles and strategies that guide the development of fluorescent-protein-based probes. A few examples are provided in each category to illustrate the corresponding principles. Since these principles are quite straightforward, others may adapt them to create fluorescent probes for their own interest. Hopefully, the development of the ever-growing family of fluorescent-protein-based probes will no longer be limited to a small number of laboratories specialized in senor development, leading to the situation that biological studies will be bettered assisted by genetically encoded sensors.

  12. Generalized Franck-Condon principle for resonant photoemission

    NASA Astrophysics Data System (ADS)

    Sałek, Paweł; Gel'mukhanov, Faris; Ågren, Hans; Björneholm, Olle; Svensson, Svante

    1999-10-01

    A generalized Franck-Condon (GFC) principle for resonant x-ray Raman scattering and for resonant photoemission in particular is derived and numerically investigated. The GFC amplitudes differ from ordinary FC amplitudes by the presence of photon and photoelectron phase factors which describe the coupling-or interference-of the x-ray photons or Auger electrons with the nuclear motion. With the GFC amplitudes, a Kramers-Heisenberg relation is obtained for vibronic transitions that corrects the so-called lifetime-vibrational interference formula. For resonant photoemission in the soft-x-ray region involving typical bound potential surfaces, the generalization gives a contribution to the FC factors that can amount to 20%. For core excitation above the dissociation threshold, the GFC principle relates to Doppler effects on the ejected photoelectron both for the so-called ``molecular'' and ``atomic'' bands. The role of the GFC principle in direct photoionization is briefly discussed.

  13. 23 CFR 627.5 - General principles and procedures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... project meeting the project criteria in 23 CFR 627.1(a), the STDs shall fulfill the value engineering... Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS VALUE ENGINEERING § 627.5 General principles and procedures. (a) State VE programs. State...

  14. 2 CFR 200.49 - Generally Accepted Accounting Principles (GAAP).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Generally Accepted Accounting Principles (GAAP). 200.49 Section 200.49 Grants and Agreements Office of Management and Budget Guidance for Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GUIDANCE Reserved UNIFORM ADMINISTRATIVE...

  15. 34 CFR 75.530 - General cost principles.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false General cost principles. 75.530 Section 75.530... determining costs applicable to grants and cost-type contracts under grants are specified at 34 CFR 74.27 (for administration of grants to institutions of higher education, and other non-profit organizations) and 34 CFR...

  16. Quaternionic quantization principle in general relativity and supergravity

    NASA Astrophysics Data System (ADS)

    Kober, Martin

    2016-01-01

    A generalized quantization principle is considered, which incorporates nontrivial commutation relations of the components of the variables of the quantized theory with the components of the corresponding canonical conjugated momenta referring to other space-time directions. The corresponding commutation relations are formulated by using quaternions. At the beginning, this extended quantization concept is applied to the variables of quantum mechanics. The resulting Dirac equation and the corresponding generalized expression for plane waves are formulated and some consequences for quantum field theory are considered. Later, the quaternionic quantization principle is transferred to canonical quantum gravity. Within quantum geometrodynamics as well as the Ashtekar formalism, the generalized algebraic properties of the operators describing the gravitational observables and the corresponding quantum constraints implied by the generalized representations of these operators are determined. The generalized algebra also induces commutation relations of the several components of the quantized variables with each other. Finally, the quaternionic quantization procedure is also transferred to 𝒩 = 1 supergravity. Accordingly, the quantization principle has to be generalized to be compatible with Dirac brackets, which appear in canonical quantum supergravity.

  17. The action principle for generalized fluid motion including gyroviscosity

    NASA Astrophysics Data System (ADS)

    Lingam, M.; Morrison, P. J.

    2014-11-01

    A general set of fluid equations that allow for energy-conserving momentum transport by gyroscopic motion of fluid elements is obtained. The equations are produced by a class of action principles that yield a large subset of the known fluid and magnetofluid models, including gyroviscosity. Analysis of the action principle yields broad, model-independent results regarding the conservation laws of energy and linear and angular momenta. The formalism is illustrated by studying fluid models with intrinsic angular momentum that may appear in the contexts of condensed matter, biological, and other areas of physics.

  18. Generalized uncertainty principle: implications for black hole complementarity

    NASA Astrophysics Data System (ADS)

    Chen, Pisin; Ong, Yen Chin; Yeom, Dong-han

    2014-12-01

    At the heart of the black hole information loss paradox and the firewall controversy lies the conflict between quantum mechanics and general relativity. Much has been said about quantum corrections to general relativity, but much less in the opposite direction. It is therefore crucial to examine possible corrections to quantum mechanics due to gravity. Indeed, the Heisenberg Uncertainty Principle is one profound feature of quantum mechanics, which nevertheless may receive correction when gravitational effects become important. Such generalized uncertainty principle [GUP] has been motivated from not only quite general considerations of quantum mechanics and gravity, but also string theoretic arguments. We examine the role of GUP in the context of black hole complementarity. We find that while complementarity can be violated by large N rescaling if one assumes only the Heisenberg's Uncertainty Principle, the application of GUP may save complementarity, but only if certain N -dependence is also assumed. This raises two important questions beyond the scope of this work, i.e., whether GUP really has the proposed form of N -dependence, and whether black hole complementarity is indeed correct.

  19. Some General Principles in Cryogenic Design, Implementation, and Testing

    NASA Technical Reports Server (NTRS)

    Dipirro, Michael James

    2015-01-01

    Brief Course Description: In 2 hours only the most basic principles of cryogenics can be presented. I will concentrate on the differences between a room temperature thermal analysis and cryogenic thermal analysis, namely temperature dependent properties. I will talk about practical materials for thermal contact and isolation. I will finish by describing the verification process and instrumentation used that is unique to cryogenic (in general less than 100K) systems.

  20. Quantum black hole in the generalized uncertainty principle framework

    SciTech Connect

    Bina, A.; Moslehi, A.; Jalalzadeh, S.

    2010-01-15

    In this paper we study the effects of the generalized uncertainty principle (GUP) on canonical quantum gravity of black holes. Through the use of modified partition function that involves the effects of the GUP, we obtain the thermodynamical properties of the Schwarzschild black hole. We also calculate the Hawking temperature and entropy for the modification of the Schwarzschild black hole in the presence of the GUP.

  1. Generalized uncertainty principle in Bianchi type I quantum cosmology

    NASA Astrophysics Data System (ADS)

    Vakili, B.; Sepangi, H. R.

    2007-07-01

    We study a quantum Bianchi type I model in which the dynamical variables of the corresponding minisuperspace obey the generalized Heisenberg algebra. Such a generalized uncertainty principle has its origin in the existence of a minimal length suggested by quantum gravity and sting theory. We present approximate analytical solutions to the corresponding Wheeler DeWitt equation in the limit where the scale factor of the universe is small and compare the results with the standard commutative and noncommutative quantum cosmology. Similarities and differences of these solutions are also discussed.

  2. Constraining the generalized uncertainty principle with cold atoms

    NASA Astrophysics Data System (ADS)

    Gao, Dongfeng; Zhan, Mingsheng

    2016-07-01

    Various theories of quantum gravity predict the existence of a minimum length scale, which implies the Planck-scale modifications of the Heisenberg uncertainty principle to a so-called generalized uncertainty principle (GUP). Previous studies of the GUP focused on its implications for high-energy physics, cosmology, and astrophysics. Here the application of the GUP to low-energy quantum systems, and particularly cold atoms, is studied. Results from the 87Rb atom recoil experiment are used to set upper bounds on parameters in three different GUP proposals. A 1014-level bound on the Ali-Das-Vagenas proposal is found, which is the second best bound so far. A 1026-level bound on Maggiore's proposal is obtained, which turns out to be the best available bound on it.

  3. Minisuperspace dynamics in a generalized uncertainty principle framework

    SciTech Connect

    Battisti, Marco Valerio; Montani, Giovanni

    2008-01-03

    The minisuperspace dynamics of the Friedmann-Robertson-Walker (FRW) and of the Taub Universes in the context of a Generalized Uncertainty Principle is analyzed in detail. In particular, the motion of the wave packets is investigated and, in both the models, the classical singularity appear to be probabilistic suppressed. Moreover, the FRW wave packets approach the Planckian region in a stationary way and no evidences for a Big-Bounce, as predicted in Loop Quantum Cosmology, appear. On the other hand, the Taub wave packets provide the right behavior in predicting an isotropic Universe.

  4. A general maximum entropy framework for thermodynamic variational principles

    SciTech Connect

    Dewar, Roderick C.

    2014-12-05

    Minimum free energy principles are familiar in equilibrium thermodynamics, as expressions of the second law. They also appear in statistical mechanics as variational approximation schemes, such as the mean-field and steepest-descent approximations. These well-known minimum free energy principles are here unified and extended to any system analyzable by MaxEnt, including non-equilibrium systems. The MaxEnt Lagrangian associated with a generic MaxEnt distribution p defines a generalized potential Ψ for an arbitrary probability distribution p-hat, such that Ψ is a minimum at (p-hat) = p. Minimization of Ψ with respect to p-hat thus constitutes a generic variational principle, and is equivalent to minimizing the Kullback-Leibler divergence between p-hat and p. Illustrative examples of min–Ψ are given for equilibrium and non-equilibrium systems. An interpretation of changes in Ψ is given in terms of the second law, although min–Ψ itself is an intrinsic variational property of MaxEnt that is distinct from the second law.

  5. Cosmological constant implementing Mach principle in general relativity

    NASA Astrophysics Data System (ADS)

    Namavarian, Nadereh; Farhoudi, Mehrdad

    2016-10-01

    We consider the fact that noticing on the operational meaning of the physical concepts played an impetus role in the appearance of general relativity (GR). Thus, we have paid more attention to the operational definition of the gravitational coupling constant in this theory as a dimensional constant which is gained through an experiment. However, as all available experiments just provide the value of this constant locally, this coupling constant can operationally be meaningful only in a local area. Regarding this point, to obtain an extension of GR for the large scale, we replace it by a conformal invariant model and then, reduce this model to a theory for the cosmological scale via breaking down the conformal symmetry through singling out a specific conformal frame which is characterized by the large scale characteristics of the universe. Finally, we come to the same field equations that historically were proposed by Einstein for the cosmological scale (GR plus the cosmological constant) as the result of his endeavor for making GR consistent with the Mach principle. However, we declare that the obtained field equations in this alternative approach do not carry the problem of the field equations proposed by Einstein for being consistent with Mach's principle (i.e., the existence of de Sitter solution), and can also be considered compatible with this principle in the Sciama view.

  6. Generalized Uncertainty Principle and Thermostatistics: A Semiclassical Approach

    NASA Astrophysics Data System (ADS)

    Abbasiyan-Motlaq, Mohammad; Pedram, Pouria

    2016-04-01

    We present an exact treatment of the thermodynamics of physical systems in the framework of the generalized uncertainty principle (GUP). Our purpose is to study and compare the consequences of two GUPs that one implies a minimal length while the other predicts a minimal length and a maximal momentum. Using a semiclassical method, we exactly calculate the modified internal energies and heat capacities in the presence of generalized commutation relations. We show that the total shift in these quantities only depends on the deformed algebra not on the system under study. Finally, the modified internal energy for an specific physical system such as ideal gas is obtained in the framework of two different GUPs.

  7. Explaining Compound Generalization in Associative and Causal Learning Through Rational Principles of Dimensional Generalization

    PubMed Central

    Soto, Fabian A.; Gershman, Samuel J.; Niv, Yael

    2014-01-01

    How do we apply learning from one situation to a similar, but not identical, situation? The principles governing the extent to which animals and humans generalize what they have learned about certain stimuli to novel compounds containing those stimuli vary depending on a number of factors. Perhaps the best studied among these factors is the type of stimuli used to generate compounds. One prominent hypothesis is that different generalization principles apply depending on whether the stimuli in a compound are similar or dissimilar to each other. However, the results of many experiments cannot be explained by this hypothesis. Here we propose a rational Bayesian theory of compound generalization that uses the notion of consequential regions, first developed in the context of rational theories of multidimensional generalization, to explain the effects of stimulus factors on compound generalization. The model explains a large number of results from the compound generalization literature, including the influence of stimulus modality and spatial contiguity on the summation effect, the lack of influence of stimulus factors on summation with a recovered inhibitor, the effect of spatial position of stimuli on the blocking effect, the asymmetrical generalization decrement in overshadowing and external inhibition, and the conditions leading to a reliable external inhibition effect. By integrating rational theories of compound and dimensional generalization, our model provides the first comprehensive computational account of the effects of stimulus factors on compound generalization, including spatial and temporal contiguity between components, which have posed longstanding problems for rational theories of associative and causal learning. PMID:25090430

  8. [General principles of tumour biology in visceral surgery].

    PubMed

    Emons, G; Ghadimi, M; Grade, M

    2015-02-01

    Within the last decade, there has been a tremendous progress in understanding the molecular basis of cancer. In particular, the development and the characteristic features of cancer cells are being increasingly understood. The understanding of these molecular characteristics is mandatory for the development of novel, targeted therapeutic strategies and their integration into clinical practice. In addition, tumour genetics play a critically important role for hereditary cancer syndromes, with respect to both diagnostics and clinical decision-making. The aim of this review is to highlight general principles of tumour genetics from a visceral surgeon's point of view, although a comprehensive summary of all aspects would be beyond the scope of this article due to the complexity of the topic.

  9. Generalized Uncertainty Principle and Parikh-Wilczek Tunneling

    NASA Astrophysics Data System (ADS)

    Mehdipour, S. Hamid

    We investigate the modifications of the Hawking radiation by the Generalized Uncertainty Principle (GUP) and the tunneling process. By using the GUP-corrected de Broglie wavelength, the squeezing of the fundamental momentum cell, and consequently a GUP-corrected energy, we find the nonthermal effects which lead to a nonzero statistical correlation function between probabilities of tunneling of two massive particles with different energies. Then the recovery of part of the information from the black hole radiation is feasible. From the other point of view, the inclusion of the effects of quantum gravity as the GUP expression can halt the evaporation process, so that a stable black hole remnant is left behind, including the other part of the black hole information content. Therefore, these features of the Planck-scale corrections may solve the information problem in black hole evaporation.

  10. An interesting consequence of the general principle of relativity

    NASA Astrophysics Data System (ADS)

    Grøn, Øyvind; Jemterud, Torkild

    2016-04-01

    We show that Einstein's general theory of relativity, together with the assumption that the principle of relativity encompasses rotational motion, predicts that in a flat Friedmann-Lemaitre-Robertson-Walker (FLRW) universe model with dust and Lorentz Invariant Vacuum Energy (LIVE), the density parameter of vacuum energy must have the value Ω_{Λ 0}=0.737. The physical mechanism connecting the relativity of rotational motion with the energy density of dark energy is the inertial dragging effect. The predicted value is necessary in order to have perfect inertial dragging, which is required for rotational motion to be relative. If one accepts that due to the impossibility of defining motion for a single particle in an otherwise empty universe, the universe must be constructed so that all types of motion are relative, then this solves the so-called cosmological constant problem.

  11. Entropy principle, non-regular processes, and generalized exploitation procedures

    NASA Astrophysics Data System (ADS)

    Triani, V.; Cimmelli, V. A.

    2012-06-01

    The classical Coleman-Noll approach to the exploitation of the entropy principle regards the classical balances of mass, linear and angular momentum and energy as differential constraints for the entropy inequality, and presupposes that the second law of thermodynamics is a restriction on the constitutive equations describing the material properties [B. D. Coleman and W. Noll, "The thermodynamics of elastic materials with heat conduction and viscosity," Arch. Rational Mech. Anal. 13, 167-178 (1963), 10.1007/BF01262690]. In 1996, Muschik and Ehrentraut proved that this presupposition may be confirmed by a rigorous proof, provided that an amendment to the classical second law of thermodynamics, which asserts that, except in equilibria, reversible process directions in state space do not exist, is postulated ["An amendment to the second law," J. Non-Equilib. Thermodyn. 21, 175-192 (1996), 10.1515/jnet.1996.21.2.175]. In their paper, the authors considered regular processes only. In a recent article [V. Triani and V. A. Cimmelli, "Interpretation of second law of thermodynamics in the presence of interfaces," Continuum. Mech. Thermodyn. 24, 165-174 (2012), 10.1007/s00161-011-0231-8], we proved that the result above remains valid in the presence of interfaces across which the unknown fields suffer jump discontinuities. Here, we show that the same conclusions achieved by Muschik and Ehrentraut and Triani and Cimmelli hold when the classical Coleman-Noll and Liu ["Method of Lagrange multipliers for exploitation of the entropy principle," Arch. Rational Mech. Anal. 46, 131-148 (1972), 10.1007/BF00250688] procedures for the exploitation of the second law, are generalized by considering also the gradients of the fundamental balance equations as constraints for the entropy inequality.

  12. Modeling of space environment impact on nanostructured materials. General principles

    NASA Astrophysics Data System (ADS)

    Voronina, Ekaterina; Novikov, Lev

    2016-07-01

    In accordance with the resolution of ISO TC20/SC14 WG4/WG6 joint meeting, Technical Specification (TS) 'Modeling of space environment impact on nanostructured materials. General principles' which describes computer simulation methods of space environment impact on nanostructured materials is being prepared. Nanomaterials surpass traditional materials for space applications in many aspects due to their unique properties associated with nanoscale size of their constituents. This superiority in mechanical, thermal, electrical and optical properties will evidently inspire a wide range of applications in the next generation spacecraft intended for the long-term (~15-20 years) operation in near-Earth orbits and the automatic and manned interplanetary missions. Currently, ISO activity on developing standards concerning different issues of nanomaterials manufacturing and applications is high enough. Most such standards are related to production and characterization of nanostructures, however there is no ISO documents concerning nanomaterials behavior in different environmental conditions, including the space environment. The given TS deals with the peculiarities of the space environment impact on nanostructured materials (i.e. materials with structured objects which size in at least one dimension lies within 1-100 nm). The basic purpose of the document is the general description of the methodology of applying computer simulation methods which relate to different space and time scale to modeling processes occurring in nanostructured materials under the space environment impact. This document will emphasize the necessity of applying multiscale simulation approach and present the recommendations for the choice of the most appropriate methods (or a group of methods) for computer modeling of various processes that can occur in nanostructured materials under the influence of different space environment components. In addition, TS includes the description of possible

  13. General principles and stages of optimal AFCS design

    NASA Astrophysics Data System (ADS)

    Platonov, A.; Zaitsev, Ie.

    2014-11-01

    The goal of the paper is a discussion of general principle and stages of the optimal analog feedback communication systems (AFCS) design. Previous research devoted to the analysis of particularities of AFCS functioning gave necessary analytical basis for transition to practical design of optimal AFCS. This is new class of communication systems (CS) transmitting the signals, under given bit error rate (BER), with bit rate equal to the capacity of the forward channel and power-bandwidth efficiency attaining the theoretical limit. In the paper, we describe the ordered sequence of the stages of transition from the abstract results to designing of the pre-commercial versions of optimal AFCS considering them as the basic communication link "sensor node (SN)" - "base station" (BS) of the wireless sensor network (WSN). We also show that verified theoretical results enable analytically argued decision making at different stages of designing of the high quality and energy efficient WSN communication links. This facilitates optimisation of the project works schedule, distribution of the tasks and resources for their realization, reduce the time and cost of design.

  14. Uncovering the Extent of the Phraseological Tendency: Towards a Systematic Analysis of Concgrams

    ERIC Educational Resources Information Center

    Cheng, Winnie; Greaves, Chris; Sinclair, John McH.; Warren, Martin

    2009-01-01

    This paper offers an analytical procedure for identifying phraseological variation within "concgrams" (Cheng et al. 2006), which are sets of words that co-occur regardless of constituency variation (e.g. AB and A * B), positional variation (e.g. AB and BA), or both. It argues that examining concgrams takes us closer to more fully appreciating and…

  15. Investigating Academic Phraseology through Combinations of Very Frequent Words: A Methodological Exploration

    ERIC Educational Resources Information Center

    Vincent, Benet

    2013-01-01

    This study demonstrates an approach based on findings from phraseology which can be used to identify potentially useful phrases in a text by starting with continuous or discontinuous sequences of very frequent words. These combinations are then searched in a corpus of academic texts to find their common collocates and ascertain whether the…

  16. Collocational Processing in Light of the Phraseological Continuum Model: Does Semantic Transparency Matter?

    ERIC Educational Resources Information Center

    Gyllstad, Henrik; Wolter, Brent

    2016-01-01

    The present study investigates whether two types of word combinations (free combinations and collocations) differ in terms of processing by testing Howarth's Continuum Model based on word combination typologies from a phraseological tradition. A visual semantic judgment task was administered to advanced Swedish learners of English (n = 27) and…

  17. Adverbials of Result: Phraseology and Functions in the Problem-Solution Pattern

    ERIC Educational Resources Information Center

    Charles, Maggie

    2011-01-01

    This paper combines the use of corpus techniques with discourse analysis in order to investigate adverbials of result in the writing of advanced academic student writers. It focuses in detail on the phraseology and functions of "thus," "therefore," "then," "hence," "so" and "consequently." Two corpora of native-speaker theses are examined: 190,000…

  18. 12 CFR 621.3 - Application of generally accepted accounting principles.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Application of generally accepted accounting principles. 621.3 Section 621.3 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ACCOUNTING AND REPORTING REQUIREMENTS General Rules § 621.3 Application of generally accepted accounting principles. Each institution shall: (a) Prepare...

  19. General rule for boundary conditions from the action principle

    NASA Astrophysics Data System (ADS)

    Steiner, Roee

    2016-03-01

    We construct models where initial and boundary conditions can be found from the fundamental rules of physics, without the need to assume them, they will be derived from the action principle. Those constraints are established from physical viewpoint, and it is not in the form of Lagrange multipliers. We show some examples from the past and some new examples that can be useful, where constraint can be obtained from the action principle. Those actions represent physical models. We show that it is possible to use our rule to get those constraints directly.

  20. Thermodynamics of Black Holes and the Symmetric Generalized Uncertainty Principle

    NASA Astrophysics Data System (ADS)

    Dutta, Abhijit; Gangopadhyay, Sunandan

    2016-06-01

    In this paper, we have investigated the thermodynamics of Schwarzschild and Reissner-Nordström black holes using the symmetric generalised uncertainty principle which contains correction terms involving momentum and position uncertainty. The mass-temperature relationship and the heat capacity for these black holes have been computed using which the critical and remnant masses have been obtained. The entropy is found to satisfy the area law upto leading order logarithmic corrections and corrections of the form A 2 (which is a new finding in this paper) from the symmetric generalised uncertainty principle.

  1. Path Integral for Dirac oscillator with generalized uncertainty principle

    SciTech Connect

    Benzair, H.; Boudjedaa, T.; Merad, M.

    2012-12-15

    The propagator for Dirac oscillator in (1+1) dimension, with deformed commutation relation of the Heisenberg principle, is calculated using path integral in quadri-momentum representation. As the mass is related to momentum, we then adapt the space-time transformation method to evaluate quantum corrections and this latter is dependent from the point discretization interval.

  2. Principle of reciprocity solves the most important problems in bioimpedance and in general in bioelectromagnetism

    NASA Astrophysics Data System (ADS)

    Malmivuo, Jaakko

    2010-04-01

    Though the principle of reciprocity was invented by Hermann von Helmholtz already over 150 years ago, and though it is a very powerful tool in solving various important problems in bioelectromagnetism, it is not generally used. In impedance tomography the measurement sensitivity distribution has generally been misunderstood. This can be easily demonstrated with the principle of reciprocity. Some other applications of the principle of reciprocity are also discussed.

  3. 12 CFR 621.3 - Application of generally accepted accounting principles.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... management and the Farm Credit Administration, in accordance with generally accepted accounting principles... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Application of generally accepted accounting principles. 621.3 Section 621.3 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM...

  4. 12 CFR 621.3 - Application of generally accepted accounting principles.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... management and the Farm Credit Administration, in accordance with generally accepted accounting principles... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Application of generally accepted accounting principles. 621.3 Section 621.3 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM...

  5. 12 CFR 621.3 - Application of generally accepted accounting principles.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... management and the Farm Credit Administration, in accordance with generally accepted accounting principles... 12 Banks and Banking 7 2013-01-01 2013-01-01 false Application of generally accepted accounting principles. 621.3 Section 621.3 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM...

  6. 29 CFR 780.138 - Application of the general principles.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... General Scope of Agriculture âsuch Farming Operationâ-of the Farmer § 780.138 Application of the general... incident to or in conjunction with his farming operations. Such arrangements are distinguished from those... incorporated association of farmers that does not itself engage in farming operations is not engaged...

  7. 29 CFR 780.138 - Application of the general principles.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... General Scope of Agriculture âsuch Farming Operationâ-of the Farmer § 780.138 Application of the general... incident to or in conjunction with his farming operations. Such arrangements are distinguished from those... incorporated association of farmers that does not itself engage in farming operations is not engaged...

  8. 29 CFR 780.138 - Application of the general principles.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... General Scope of Agriculture âsuch Farming Operationâ-of the Farmer § 780.138 Application of the general... incident to or in conjunction with his farming operations. Such arrangements are distinguished from those... incorporated association of farmers that does not itself engage in farming operations is not engaged...

  9. 29 CFR 780.138 - Application of the general principles.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... General Scope of Agriculture âsuch Farming Operationâ-of the Farmer § 780.138 Application of the general... incident to or in conjunction with his farming operations. Such arrangements are distinguished from those... incorporated association of farmers that does not itself engage in farming operations is not engaged...

  10. 29 CFR 780.138 - Application of the general principles.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... General Scope of Agriculture âsuch Farming Operationâ-of the Farmer § 780.138 Application of the general... incident to or in conjunction with his farming operations. Such arrangements are distinguished from those... incorporated association of farmers that does not itself engage in farming operations is not engaged...

  11. A generalized energy principle for a magnetorotational instability model

    NASA Astrophysics Data System (ADS)

    Tassi, Emanuele; Morrison, Phil; Tronko, Natalia

    2012-03-01

    We study the equilibria of the Magnetorotational Instability system by using the noncanonical Hamiltonian approach [1], since it provides variational principles for equilibria that can be used to assess stability. We show that a reduced system of equations derived in [2] is an infinite-dimensional noncanonical Hamiltonian system. The noncanonical Poisson bracket is identified and shown to obey the Jacobi identity, and families of Casimir invariants are obtained. Explicit sufficient conditions for the energy stability of two classes of equilibria are identified by means of the Energy-Casimir method. Comparison between the stability conditions obtained in the two cases indicates that the presence of an equilibirum magnetic field along the direction of the ignorable coordinate does not introduce destabilizing effects. An analogy is found and physically interpreted between terms of the MRI perturbation energy and terms appearing in the energy principle stability analysis of CRMHD for tokamaks [3].[4pt] [1] P. J. Morrison, Rev. Mod. Phys., 70, 467 (1998).[0pt] [2] K. Julien and E. Knobloch, Phil. Trans. Roy. Soc., 386A,1607 (2010).[0pt] [3] R.D. Hazeltine, et. al, Phys. Fluids 28, 2466 (1985).

  12. Physical anthropology: the search for general processes and principles.

    PubMed

    Lasker, G W

    1970-02-01

    Physical anthropology consists of two interdependent types of study: (1) the biological history of man and (2) general biological processes in man (such as mechanisms of evolution and growth). Popular interest may focus on the former, the fascinating story of the origin of man and of specific people, but the latter affords physical anthropology potential practical value in respect to medicine, dentistry, public health, and population policy. The study of general processes is the study of human beings in particular situations, not for what we can learn about these particular populations but for the sake of generalization about mankind anywhere in comparable situations. This is, of course, the purpose of experimental science in general, but in anthropology the method is usually comparative. Long ago the study of the growth of the two sexes and of children in different countries was started on a comparative basis as was the study of the so-called secular change in adult stature. By 1911 Franz Boas had compared the changes in stature and head form of children of several different immigrant groups in the United States. There have since been comparative studies of the amount and distribution of body fat (but not yet adequate comparative measurements of the relation of tissue components to diet and to diseases). Demographic patterns, inbreeding, outbreeding, and their effects are other general problems. The Human Adaptability Project of the International Biological Program promises studies of human response to heat, cold, altitude, and other conditions on a wide international basis. If supported, these could turn physical anthropology's search in a useful direction. The functional biology of people of even out-of-the-way communities will be compared with each other. These studies can yield general statements concerning human response to types of ecological situation including such sociocultural conditions as those of hunting-gathering tribes and urban slums. PMID:19681215

  13. Physical anthropology: the search for general processes and principles.

    PubMed

    Lasker, G W

    1970-02-01

    Physical anthropology consists of two interdependent types of study: (1) the biological history of man and (2) general biological processes in man (such as mechanisms of evolution and growth). Popular interest may focus on the former, the fascinating story of the origin of man and of specific people, but the latter affords physical anthropology potential practical value in respect to medicine, dentistry, public health, and population policy. The study of general processes is the study of human beings in particular situations, not for what we can learn about these particular populations but for the sake of generalization about mankind anywhere in comparable situations. This is, of course, the purpose of experimental science in general, but in anthropology the method is usually comparative. Long ago the study of the growth of the two sexes and of children in different countries was started on a comparative basis as was the study of the so-called secular change in adult stature. By 1911 Franz Boas had compared the changes in stature and head form of children of several different immigrant groups in the United States. There have since been comparative studies of the amount and distribution of body fat (but not yet adequate comparative measurements of the relation of tissue components to diet and to diseases). Demographic patterns, inbreeding, outbreeding, and their effects are other general problems. The Human Adaptability Project of the International Biological Program promises studies of human response to heat, cold, altitude, and other conditions on a wide international basis. If supported, these could turn physical anthropology's search in a useful direction. The functional biology of people of even out-of-the-way communities will be compared with each other. These studies can yield general statements concerning human response to types of ecological situation including such sociocultural conditions as those of hunting-gathering tribes and urban slums.

  14. General principles of medical interconsultation for hospitalised patients.

    PubMed

    Monte-Secades, R; Montero-Ruiz, E; Gil-Díaz, A; Castiella-Herrero, J

    2016-01-01

    Medical interconsultation for hospitalised patients is a regular activity among internal medicine specialists. However, despite its growing impact and importance, a model that defines its characteristics, objectives and information has not been established. This study, conducted by the Shared Care and Interconsultations Group of the Spanish Society of Internal Medicine, proposes a number of general recommendations concerning the method for requesting and responding to hospital medical interconsultations, as well as a format for these interconsultations.

  15. 26 CFR 1.338-1 - General principles; status of old target and new target.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 4 2012-04-01 2012-04-01 false General principles; status of old target and new target. 1.338-1 Section 1.338-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... principles; status of old target and new target. (a) In general—(1) Deemed transaction. Elections...

  16. 26 CFR 1.338-1 - General principles; status of old target and new target.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 4 2013-04-01 2013-04-01 false General principles; status of old target and new target. 1.338-1 Section 1.338-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... principles; status of old target and new target. (a) In general—(1) Deemed transaction. Elections...

  17. 26 CFR 1.338-1 - General principles; status of old target and new target.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 4 2014-04-01 2014-04-01 false General principles; status of old target and new target. 1.338-1 Section 1.338-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... principles; status of old target and new target. (a) In general—(1) Deemed transaction. Elections...

  18. Students' Misunderstandings about the Energy Conservation Principle: A General View to Studies in Literature

    ERIC Educational Resources Information Center

    Tatar, Erdal; Oktay, Munir

    2007-01-01

    This paper serves to review previously reported studies on students' misunderstandings about the energy conservation principle (the first law of thermodynamics). Generally, studies in literature highlighted students' misunderstandings about the energy conservation principle stem from preliminaries about energy concept in daily life. Since prior…

  19. Guiding Principles for Including High School Students with Intellectual Disabilities in General Education Classes

    ERIC Educational Resources Information Center

    Doyle, Mary Beth; Giangreco, Michael

    2013-01-01

    This article provides teachers and administrators with a description of foundational principles and curricular approaches to create meaningful educational experiences for secondary students with intellectual disabilities in inclusive general education classes. The four principles provide: (a) the least dangerous assumption, (b) partial…

  20. Effect of the Generalized Uncertainty Principle on post-inflation preheating

    SciTech Connect

    Chemissany, Wissam; Das, Saurya; Ali, Ahmed Farag; Vagenas, Elias C. E-mail: saurya.das@uleth.ca E-mail: evagenas@academyofathens.gr

    2011-12-01

    We examine effects of the Generalized Uncertainty Principle, predicted by various theories of quantum gravity to replace the Heisenberg's uncertainty principle near the Planck scale, on post inflation preheating in cosmology, and show that it can predict either an increase or a decrease in parametric resonance and a corresponding change in particle production. Possible implications are considered.

  1. A generalized Poisson solver for first-principles device simulations

    NASA Astrophysics Data System (ADS)

    Bani-Hashemian, Mohammad Hossein; Brück, Sascha; Luisier, Mathieu; VandeVondele, Joost

    2016-01-01

    Electronic structure calculations of atomistic systems based on density functional theory involve solving the Poisson equation. In this paper, we present a plane-wave based algorithm for solving the generalized Poisson equation subject to periodic or homogeneous Neumann conditions on the boundaries of the simulation cell and Dirichlet type conditions imposed at arbitrary subdomains. In this way, source, drain, and gate voltages can be imposed across atomistic models of electronic devices. Dirichlet conditions are enforced as constraints in a variational framework giving rise to a saddle point problem. The resulting system of equations is then solved using a stationary iterative method in which the generalized Poisson operator is preconditioned with the standard Laplace operator. The solver can make use of any sufficiently smooth function modelling the dielectric constant, including density dependent dielectric continuum models. For all the boundary conditions, consistent derivatives are available and molecular dynamics simulations can be performed. The convergence behaviour of the scheme is investigated and its capabilities are demonstrated.

  2. A generalized Poisson solver for first-principles device simulations.

    PubMed

    Bani-Hashemian, Mohammad Hossein; Brück, Sascha; Luisier, Mathieu; VandeVondele, Joost

    2016-01-28

    Electronic structure calculations of atomistic systems based on density functional theory involve solving the Poisson equation. In this paper, we present a plane-wave based algorithm for solving the generalized Poisson equation subject to periodic or homogeneous Neumann conditions on the boundaries of the simulation cell and Dirichlet type conditions imposed at arbitrary subdomains. In this way, source, drain, and gate voltages can be imposed across atomistic models of electronic devices. Dirichlet conditions are enforced as constraints in a variational framework giving rise to a saddle point problem. The resulting system of equations is then solved using a stationary iterative method in which the generalized Poisson operator is preconditioned with the standard Laplace operator. The solver can make use of any sufficiently smooth function modelling the dielectric constant, including density dependent dielectric continuum models. For all the boundary conditions, consistent derivatives are available and molecular dynamics simulations can be performed. The convergence behaviour of the scheme is investigated and its capabilities are demonstrated. PMID:26827208

  3. 12 CFR 621.3 - Application of generally accepted accounting principles.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Application of generally accepted accounting principles. 621.3 Section 621.3 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ACCOUNTING AND REPORTING REQUIREMENTS General Rules § 621.3 Application of generally accepted...

  4. Earth Science Principles Pertinent to the General Education Programs in Junior High Schools

    ERIC Educational Resources Information Center

    Henson, Kenneth Tyrone

    1970-01-01

    Presents the procedures, and findings of a study designed to identify principles in astronomy, geology, meterology, oceanography and physical geography pertinent to general education programs in junior high schools. (LC)

  5. A generalized optimization principle for asymmetric branching in fluidic networks

    PubMed Central

    Stephenson, David

    2016-01-01

    When applied to a branching network, Murray’s law states that the optimal branching of vascular networks is achieved when the cube of the parent channel radius is equal to the sum of the cubes of the daughter channel radii. It is considered integral to understanding biological networks and for the biomimetic design of artificial fluidic systems. However, despite its ubiquity, we demonstrate that Murray’s law is only optimal (i.e. maximizes flow conductance per unit volume) for symmetric branching, where the local optimization of each individual channel corresponds to the global optimum of the network as a whole. In this paper, we present a generalized law that is valid for asymmetric branching, for any cross-sectional shape, and for a range of fluidic models. We verify our analytical solutions with the numerical optimization of a bifurcating fluidic network for the examples of laminar, turbulent and non-Newtonian fluid flows. PMID:27493583

  6. A generalized optimization principle for asymmetric branching in fluidic networks

    NASA Astrophysics Data System (ADS)

    Stephenson, David; Lockerby, Duncan A.

    2016-07-01

    When applied to a branching network, Murray's law states that the optimal branching of vascular networks is achieved when the cube of the parent channel radius is equal to the sum of the cubes of the daughter channel radii. It is considered integral to understanding biological networks and for the biomimetic design of artificial fluidic systems. However, despite its ubiquity, we demonstrate that Murray's law is only optimal (i.e. maximizes flow conductance per unit volume) for symmetric branching, where the local optimization of each individual channel corresponds to the global optimum of the network as a whole. In this paper, we present a generalized law that is valid for asymmetric branching, for any cross-sectional shape, and for a range of fluidic models. We verify our analytical solutions with the numerical optimization of a bifurcating fluidic network for the examples of laminar, turbulent and non-Newtonian fluid flows.

  7. Entropy of the Randall-Sundrum brane world with the generalized uncertainty principle

    SciTech Connect

    Kim, Wontae; Park, Young-Jai; Kim, Yong-Wan

    2006-11-15

    By introducing the generalized uncertainty principle, we calculate the entropy of the bulk scalar field on the Randall-Sundrum brane background without any cutoff. We obtain the entropy of the massive scalar field proportional to the horizon area. Here, we observe that the mass contribution to the entropy exists in contrast to all previous results of the usual black hole cases with the generalized uncertainty principle.

  8. Generalized energy principle for flute perturbations in axisymmetric mirror machines

    SciTech Connect

    Lansky, I.M.; Ryutov, D.D.

    1993-01-20

    Axial symmetry is a very desirable property of the mirror devices both for fusion and neutron source applications. The main obstacle to be circumvented in the development of such systems, is the flute instability of axisymmetric mirrors. In recent years there appeared a number of proposals, devoted to the stabilization of the flute perturbations in the framework of axisymmetric magnetic configurations, which are based on the combining of the MHD unstable central cell with various types of end-cell stabilizers. In the present paper we concentrate ourselves just on this scheme, including long solenoid with a uniform field, conjugated with the end stabilizing anchor, intended to provide MHD stability of the system as a whole. The attractive feature of such a configuration is that it allows to exploit finite larmor radius (FLR) effects for the stabilization of the flute perturbations. As is well known, FLR effects, being strong, stabilize all flute modes, except the one with azimuthal number m = 1, corresponding to the ``rigid`` displacement of the plasma column (the ``global`` mode). Consequently, in the conditions when FLR effects dominate, the anchor has to stabilize the ``global` mode only. Bearing in mind a favorable influence of FLR effects we, however, don`t restrict our paper by discussion of only ``global`` mode stability and consider a general case of an arbitrary azimuthal mode.

  9. A generalization of Chetaev's principle for a class of higher order nonholonomic constraints

    NASA Astrophysics Data System (ADS)

    Cendra, Hernán; Ibort, Alberto; de León, Manuel; Martín de Diego, David

    2004-07-01

    The constraint distribution in nonholonomic mechanics has a double role. On the one hand, it is a kinematic constraint, that is, it is a restriction on the motion itself. On the other hand, it is also a restriction on the allowed variations when using D'Alembert's principle to derive the equations of motion. We will show that many systems of physical interest where D'Alembert's principle does not apply can be conveniently modeled within the general idea of the principle of virtual work by the introduction of both kinematic constraints and variational constraints as being independent entities. This includes, for example, elastic rolling bodies and pneumatic tires. Also, D'Alembert's principle and Chetaev's principle fall into this scheme. We emphasize the geometric point of view, avoiding the use of local coordinates, which is the appropriate setting for dealing with questions of global nature, like reduction.

  10. Generalized Fermat's principle and action for light rays in a curved spacetime

    NASA Astrophysics Data System (ADS)

    Frolov, Valeri P.

    2013-09-01

    We start with formulation of the generalized Fermat’s principle for light propagation in a curved spacetime. We apply Pontryagin’s minimum principle of the optimal control theory and obtain an effective Hamiltonian for null geodesics in a curved spacetime. We explicitly demonstrate that dynamical equations for this Hamiltonian correctly reproduce null geodesic equations. Other forms of the action for light rays in a curved spacetime are also discussed.

  11. Communication: Maximum caliber is a general variational principle for nonequilibrium statistical mechanics.

    PubMed

    Hazoglou, Michael J; Walther, Valentin; Dixit, Purushottam D; Dill, Ken A

    2015-08-01

    There has been interest in finding a general variational principle for non-equilibrium statistical mechanics. We give evidence that Maximum Caliber (Max Cal) is such a principle. Max Cal, a variant of maximum entropy, predicts dynamical distribution functions by maximizing a path entropy subject to dynamical constraints, such as average fluxes. We first show that Max Cal leads to standard near-equilibrium results—including the Green-Kubo relations, Onsager's reciprocal relations of coupled flows, and Prigogine's principle of minimum entropy production—in a way that is particularly simple. We develop some generalizations of the Onsager and Prigogine results that apply arbitrarily far from equilibrium. Because Max Cal does not require any notion of "local equilibrium," or any notion of entropy dissipation, or temperature, or even any restriction to material physics, it is more general than many traditional approaches. It also applicable to flows and traffic on networks, for example. PMID:26254635

  12. Capturing Phraseology in an Online Dictionary for Advanced Users of English as a Second Language: A Response to User Needs.

    ERIC Educational Resources Information Center

    McAlpine, Janice; Myles, Johanne

    2003-01-01

    Proposes a new type of English-as-a-Second-Language dictionary--in electronic form--that presents typical phraseology rather than words in isolation. Online, without the constraints of space and linear organization, the dictionary can treat the multiword lexical units and common collocational patterns that cohere around a node word and illustrate…

  13. The entropy of the noncommutative acoustic black hole based on generalized uncertainty principle

    NASA Astrophysics Data System (ADS)

    Anacleto, M. A.; Brito, F. A.; Passos, E.; Santos, W. P.

    2014-10-01

    In this paper we investigate statistical entropy of a 3-dimensional rotating acoustic black hole based on generalized uncertainty principle. In our results we obtain an area entropy and a correction term associated with the noncommutative acoustic black hole when λ introduced in the generalized uncertainty principle takes a specific value. However, in this method, it is not needed to introduce the ultraviolet cut-off and divergences are eliminated. Moreover, the small mass approximation is not necessary in the original brick-wall model.

  14. What buoyancy really is. A generalized Archimedes' principle for sedimentation and ultracentrifugation

    NASA Astrophysics Data System (ADS)

    Piazza, Roberto; Buzzaccaro, Stefano; Secchi, Eleonora; Parola, Alberto

    Particle settling is a pervasive process in nature, and centrifugation is a much versatile separation technique. Yet, the results of settling and ultracentrifugation experiments often appear to contradict the very law on which they are based: Archimedes Principle - arguably, the oldest Physical Law. The purpose of this paper is delving at the very roots of the concept of buoyancy by means of a combined experimental-theoretical study on sedimentation profiles in colloidal mixtures. Our analysis shows that the standard Archimedes' principle is only a limiting approximation, valid for mesoscopic particles settling in a molecular fluid, and we provide a general expression for the actual buoyancy force. This "Generalized Archimedes Principle" accounts for unexpected effects, such as denser particles floating on top of a lighter fluid, which in fact we observe in our experiments.

  15. 20 CFR 604.3 - Able and available requirement-general principles.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...—general principles. (a) A State may pay UC only to an individual who is able to work and available for work for the week for which UC is claimed. (b) Whether an individual is able to work and available for... for an individual under its UC law. (c) The requirement that an individual be able to work...

  16. 20 CFR 604.3 - Able and available requirement-general principles.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...—general principles. (a) A State may pay UC only to an individual who is able to work and available for work for the week for which UC is claimed. (b) Whether an individual is able to work and available for... for an individual under its UC law. (c) The requirement that an individual be able to work...

  17. 20 CFR 604.3 - Able and available requirement-general principles.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...—general principles. (a) A State may pay UC only to an individual who is able to work and available for work for the week for which UC is claimed. (b) Whether an individual is able to work and available for... for an individual under its UC law. (c) The requirement that an individual be able to work...

  18. 20 CFR 604.3 - Able and available requirement-general principles.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...—general principles. (a) A State may pay UC only to an individual who is able to work and available for work for the week for which UC is claimed. (b) Whether an individual is able to work and available for... for an individual under its UC law. (c) The requirement that an individual be able to work...

  19. 20 CFR 604.3 - Able and available requirement-general principles.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...—general principles. (a) A State may pay UC only to an individual who is able to work and available for work for the week for which UC is claimed. (b) Whether an individual is able to work and available for... for an individual under its UC law. (c) The requirement that an individual be able to work...

  20. 49 CFR Appendix E to Part 238 - General Principles of Reliability-Based Maintenance Programs

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Maintenance Programs E Appendix E to Part 238 Transportation Other Regulations Relating to Transportation... STANDARDS Pt. 238, App. E Appendix E to Part 238—General Principles of Reliability-Based Maintenance... reliability beyond the design reliability. (e) When a maintenance program is developed, it includes tasks...

  1. 26 CFR 1.338-1 - General principles; status of old target and new target.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 4 2011-04-01 2011-04-01 false General principles; status of old target and new target. 1.338-1 Section 1.338-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... of old target and new target. (a) In general—(1) Deemed transaction. Elections are available...

  2. 26 CFR 1.338-1 - General principles; status of old target and new target.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 4 2010-04-01 2010-04-01 false General principles; status of old target and new target. 1.338-1 Section 1.338-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... of old target and new target. (a) In general—(1) Deemed transaction. Elections are available...

  3. 43 CFR 419.3 - What general principles govern implementation of the TROA?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... emergencies presenting a clear and immediate danger to public health, life, property, or essential public... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false What general principles govern implementation of the TROA? 419.3 Section 419.3 Public Lands: Interior Regulations Relating to Public...

  4. 21 CFR 570.20 - General principles for evaluating the safety of food additives.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 6 2011-04-01 2011-04-01 false General principles for evaluating the safety of food additives. 570.20 Section 570.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS FOOD ADDITIVES Food...

  5. 21 CFR 170.20 - General principles for evaluating the safety of food additives.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... the safety of a food additive whether he believes the experiments planned will yield data adequate for... 21 Food and Drugs 3 2011-04-01 2011-04-01 false General principles for evaluating the safety of food additives. 170.20 Section 170.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF...

  6. 21 CFR 570.20 - General principles for evaluating the safety of food additives.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false General principles for evaluating the safety of food additives. 570.20 Section 570.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS FOOD ADDITIVES Food...

  7. 21 CFR 170.20 - General principles for evaluating the safety of food additives.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the safety of a food additive whether he believes the experiments planned will yield data adequate for... 21 Food and Drugs 3 2010-04-01 2009-04-01 true General principles for evaluating the safety of food additives. 170.20 Section 170.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF...

  8. 21 CFR 170.20 - General principles for evaluating the safety of food additives.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... food additives. 170.20 Section 170.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVES Food Additive Safety § 170.20 General principles for evaluating the safety of food additives. (a) In reaching...

  9. 21 CFR 170.20 - General principles for evaluating the safety of food additives.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... food additives. 170.20 Section 170.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVES Food Additive Safety § 170.20 General principles for evaluating the safety of food additives. (a) In reaching...

  10. 21 CFR 570.20 - General principles for evaluating the safety of food additives.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... food additives. 570.20 Section 570.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS FOOD ADDITIVES Food Additive Safety § 570.20 General principles for evaluating the safety of food additives. (a) In reaching...

  11. 21 CFR 570.20 - General principles for evaluating the safety of food additives.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... food additives. 570.20 Section 570.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS FOOD ADDITIVES Food Additive Safety § 570.20 General principles for evaluating the safety of food additives. (a) In reaching...

  12. The Basic Principles and Methods of the Music Curriculum for the General Education School.

    ERIC Educational Resources Information Center

    Kabalevskii, Dmitrii

    1988-01-01

    Delineates the foundations of Dmitri Kabalevskii's music curriculum for general education in the Soviet Union. Stresses teaching music as part of life itself. Bases teaching principles and methods on the song, dance, and march, termed "The Three Whales." Offers extensive lesson plans focusing on first grade music activities. (CH)

  13. Using Domain-General Principles to Explain Children's Causal Reasoning Abilities

    ERIC Educational Resources Information Center

    McClelland, James L.; Thompson, Richard M.

    2007-01-01

    A connectionist model of causal attribution is presented, emphasizing the use of domain-general principles of processing and learning previously employed in models of semantic cognition. The model categorizes objects dependent upon their observed 'causal properties' and is capable of making several types of inferences that 4-year-old children have…

  14. 49 CFR Appendix E to Part 238 - General Principles of Reliability-Based Maintenance Programs

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Maintenance Programs E Appendix E to Part 238 Transportation Other Regulations Relating to Transportation... STANDARDS Pt. 238, App. E Appendix E to Part 238—General Principles of Reliability-Based Maintenance... reliability beyond the design reliability. (e) When a maintenance program is developed, it includes tasks...

  15. 21 CFR 312.22 - General principles of the IND submission.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 5 2014-04-01 2014-04-01 false General principles of the IND submission. 312.22 Section 312.22 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE INVESTIGATIONAL NEW DRUG APPLICATION Investigational New Drug...

  16. English Phraseological Units with an Onomastic Element and their Translation Equivalents in Slovene.

    PubMed

    Vrbinc, Marjeta

    2016-04-01

    This article presents the findings of the study where 173 English onomastic phraseological units (PUs) were classified according to their translations into Slovene. Four groups were identified. More than 61% of all PUs belongs to the group where the translation equivalent is either descriptive or represented by a one-word equivalent. This group is followed by two groups amounting to 18.50%, i.e., a group where the English PU is translated idiomatically with a proper name and a group where it is translated idiomatically with the same proper name. The smallest group where the English PU istranslated by means of a different proper name amounts to less than 2%. It is evident that non-idiomatic descriptive translation or one-word equivalents exceed idiomatic translations of any kind, and that the majority of PUs in both languages are highly culture-specific, thus posing problems to non-native speakers in comprehension and translation. PMID:27301236

  17. Victim Injury and Social Distance: A National Test of a General Principle of Conflict.

    PubMed

    Rennison, Callie Marie; Jacques, Scott; Allen, Andrea

    2016-01-01

    Our inquiry focuses on why some violent offenses but not others result in injury to the victim. Building on existing theory nested in the paradigm of pure sociology, we propose and test a general principle of conflict: Victim injury varies directly with social distance. This principle predicts that offenders are more likely to harm victims with whom they are less well acquainted and less similar culturally. We test three hypotheses derived from this principle with data from the National Crime Victimization Survey and find little support for the theory. Rather, findings suggest exactly the opposite of that predicted: As social distance between offender and victim increases, the odds of victim injury decreases. Recommendations of additional research are made. PMID:27302957

  18. Energy distribution of massless particles on black hole backgrounds with generalized uncertainty principle

    SciTech Connect

    Li Zhongheng

    2009-10-15

    We derive new formulas for the spectral energy density and total energy density of massless particles in a general spherically symmetric static metric from a generalized uncertainty principle. Compared with blackbody radiation, the spectral energy density is strongly damped at high frequencies. For large values of r, the spectral energy density diminishes when r grows, but at the event horizon, the spectral energy density vanishes and therefore thermodynamic quantities near a black hole, calculated via the generalized uncertainty principle, do not require any cutoff parameter. We find that the total energy density can be expressed in terms of Hurwitz zeta functions. It should be noted that at large r (low local temperature), the difference between the total energy density and the Stefan-Boltzmann law is too small to be observed. However, as r approaches an event horizon, the effect of the generalized uncertainty principle becomes more and more important, which may be observable. As examples, the spectral energy densities in the background metric of a Schwarzschild black hole and of a Schwarzschild black hole plus quintessence are discussed. It is interesting to note that the maximum of the distribution shifts to higher frequencies when the quintessence equation of state parameter w decreases.

  19. Maximum Principle for General Controlled Systems Driven by Fractional Brownian Motions

    SciTech Connect

    Han Yuecai; Hu Yaozhong; Song Jian

    2013-04-15

    We obtain a maximum principle for stochastic control problem of general controlled stochastic differential systems driven by fractional Brownian motions (of Hurst parameter H>1/2). This maximum principle specifies a system of equations that the optimal control must satisfy (necessary condition for the optimal control). This system of equations consists of a backward stochastic differential equation driven by both fractional Brownian motions and the corresponding underlying standard Brownian motions. In addition to this backward equation, the maximum principle also involves the Malliavin derivatives. Our approach is to use conditioning and Malliavin calculus. To arrive at our maximum principle we need to develop some new results of stochastic analysis of the controlled systems driven by fractional Brownian motions via fractional calculus. Our approach of conditioning and Malliavin calculus is also applied to classical system driven by standard Brownian motions while the controller has only partial information. As a straightforward consequence, the classical maximum principle is also deduced in this more natural and simpler way.

  20. Covariant energy–momentum and an uncertainty principle for general relativity

    SciTech Connect

    Cooperstock, F.I.; Dupre, M.J.

    2013-12-15

    We introduce a naturally-defined totally invariant spacetime energy expression for general relativity incorporating the contribution from gravity. The extension links seamlessly to the action integral for the gravitational field. The demand that the general expression for arbitrary systems reduces to the Tolman integral in the case of stationary bounded distributions, leads to the matter-localized Ricci integral for energy–momentum in support of the energy localization hypothesis. The role of the observer is addressed and as an extension of the special relativistic case, the field of observers comoving with the matter is seen to compute the intrinsic global energy of a system. The new localized energy supports the Bonnor claim that the Szekeres collapsing dust solutions are energy-conserving. It is suggested that in the extreme of strong gravity, the Heisenberg Uncertainty Principle be generalized in terms of spacetime energy–momentum. -- Highlights: •We present a totally invariant spacetime energy expression for general relativity incorporating the contribution from gravity. •Demand for the general expression to reduce to the Tolman integral for stationary systems supports the Ricci integral as energy–momentum. •Localized energy via the Ricci integral is consistent with the energy localization hypothesis. •New localized energy supports the Bonnor claim that the Szekeres collapsing dust solutions are energy-conserving. •Suggest the Heisenberg Uncertainty Principle be generalized in terms of spacetime energy–momentum in strong gravity extreme.

  1. General Principles of Radiation Protection in Fields of Diagnostic Medical Exposure

    PubMed Central

    2016-01-01

    After the rapid development of medical equipment including CT or PET-CT, radiation doses from medical exposure are now the largest source of man-made radiation exposure. General principles of radiation protection from the hazard of ionizing radiation are summarized as three key words; justification, optimization, and dose limit. Because medical exposure of radiation has unique considerations, diagnostic reference level is generally used as a reference value, instead of dose limits. In Korea, medical radiation exposure has increased rapidly. For medical radiation exposure control, Korea has two separate control systems. Regulation is essential to control medical radiation exposure. Physicians and radiologists must be aware of the radiation risks and benefits associated with medical exposure, and understand and implement the principles of radiation protection for patients. The education of the referring physicians and radiologists is also important. PMID:26908991

  2. On the reduction principle for differential equations with piecewise constant argument of generalized type

    NASA Astrophysics Data System (ADS)

    Akhmet, M. U.

    2007-12-01

    In this paper we introduce a new type of differential equations with piecewise constant argument (EPCAG), more general than EPCA [K.L. Cooke, J. Wiener, Retarded differential equations with piecewise constant delays, J. Math. Anal. Appl. 99 (1984) 265-297; J. Wiener, Generalized Solutions of Functional Differential Equations, World Scientific, Singapore, 1993]. The Reduction Principle [V.A. Pliss, The reduction principle in the theory of the stability of motion, Izv. Akad. Nauk SSSR Ser. Mat. 27 (1964) 1297-1324 (in Russian); V.A. Pliss, Integral Sets of Periodic Systems of Differential Equations, Nauka, Moskow, 1977 (in Russian)] is proved for EPCAG. The structure of the set of solutions is specified. We establish also the existence of global integral manifolds of quasilinear EPCAG in the so-called critical case and investigate the stability of the zero solution.

  3. Nonlinear Schrödinger equation from generalized exact uncertainty principle

    NASA Astrophysics Data System (ADS)

    Rudnicki, Łukasz

    2016-09-01

    Inspired by the generalized uncertainty principle, which adds gravitational effects to the standard description of quantum uncertainty, we extend the exact uncertainty principle approach by Hall and Reginatto (2002 J. Phys. A: Math. Gen. 35 3289), and obtain a (quasi)nonlinear Schrödinger equation. This quantum evolution equation of unusual form, enjoys several desired properties like separation of non-interacting subsystems or plane-wave solutions for free particles. Starting with the harmonic oscillator example, we show that every solution of this equation respects the gravitationally induced minimal position uncertainty proportional to the Planck length. Quite surprisingly, our result successfully merges the core of classical physics with non-relativistic quantum mechanics in its extremal form. We predict that the commonly accepted phenomenon, namely a modification of a free-particle dispersion relation due to quantum gravity might not occur in reality.

  4. Generalized uncertainty principle in f(R) gravity for a charged black hole

    SciTech Connect

    Said, Jackson Levi; Adami, Kristian Zarb

    2011-02-15

    Using f(R) gravity in the Palatini formularism, the metric for a charged spherically symmetric black hole is derived, taking the Ricci scalar curvature to be constant. The generalized uncertainty principle is then used to calculate the temperature of the resulting black hole; through this the entropy is found correcting the Bekenstein-Hawking entropy in this case. Using the entropy the tunneling probability and heat capacity are calculated up to the order of the Planck length, which produces an extra factor that becomes important as black holes become small, such as in the case of mini-black holes.

  5. [Protection of genetic data in Spain. Analysis based on the general principles of personal data protection].

    PubMed

    García Amez, Javier

    2006-01-01

    The genetic data is Spain is not regulated specifically, rather, we must look at the regulation on the protection of data of a personal nature. This is turn, establishes a series of general principles to apply to any type of data. Analysing this with other regulations that are dispersed both in the national and international regulations, we can deduce the rights and obligations in this field. This highlights the fact that one can't dispose of the genetic data in the same manner as the personal data.

  6. Impacts of generalized uncertainty principle on black hole thermodynamics and Salecker-Wigner inequalities

    SciTech Connect

    Tawfik, A.

    2013-07-01

    We investigate the impacts of Generalized Uncertainty Principle (GUP) proposed by some approaches to quantum gravity such as String Theory and Doubly Special Relativity on black hole thermodynamics and Salecker-Wigner inequalities. Utilizing Heisenberg uncertainty principle, the Hawking temperature, Bekenstein entropy, specific heat, emission rate and decay time are calculated. As the evaporation entirely eats up the black hole mass, the specific heat vanishes and the temperature approaches infinity with an infinite radiation rate. It is found that the GUP approach prevents the black hole from the entire evaporation. It implies the existence of remnants at which the specific heat vanishes. The same role is played by the Heisenberg uncertainty principle in constructing the hydrogen atom. We discuss how the linear GUP approach solves the entire-evaporation-problem. Furthermore, the black hole lifetime can be estimated using another approach; the Salecker-Wigner inequalities. Assuming that the quantum position uncertainty is limited to the minimum wavelength of measuring signal, Wigner second inequality can be obtained. If the spread of quantum clock is limited to some minimum value, then the modified black hole lifetime can be deduced. Based on linear GUP approach, the resulting lifetime difference depends on black hole relative mass and the difference between black hole mass with and without GUP is not negligible.

  7. Supramolecular chemistry-general principles and selected examples from anion recognition and metallosupramolecular chemistry.

    PubMed

    Albrecht, Markus

    2007-12-01

    This review gives an introduction into supramolecular chemistry describing in the first part general principles, focusing on terms like noncovalent interaction, molecular recognition, self-assembly, and supramolecular function. In the second part those will be illustrated by simple examples from our laboratories. Supramolecular chemistry is the science that bridges the gap between the world of molecules and nanotechnology. In supramolecular chemistry noncovalent interactions occur between molecular building blocks, which by molecular recognition and self-assembly form (functional) supramolecular entities. It is also termed the "chemistry of the noncovalent bond." Molecular recognition is based on geometrical complementarity based on the "key-and-lock" principle with nonshape-dependent effects, e.g., solvatization, being also highly influential. Self-assembly leads to the formation of well-defined aggregates. Hereby the overall structure of the target ensemble is controlled by the symmetry features of the certain building blocks. Finally, the aggregates can possess special properties or supramolecular functions, which are only found in the ensemble but not in the participating molecules. This review gives an introduction on supramolecular chemistry and illustrates the fundamental principles by recent examples from our group.

  8. General proof of the entropy principle for self-gravitating fluid in f ( R) gravity

    NASA Astrophysics Data System (ADS)

    Fang, Xiongjun; Guo, Minyong; Jing, Jiliang

    2016-08-01

    The discussions on the connection between gravity and thermodynamics attract much attention recently. We consider a static self-gravitating perfect fluid system in f ( R) gravity, which is an important theory could explain the accelerated expansion of the universe. We first show that the Tolman-Oppenheimer-Volkoff equation of f ( R) theories can be obtained by thermodynamical method in spherical symmetric spacetime. Then we prove that the maximum entropy principle is also valid for f ( R) gravity in general static spacetimes beyond spherical symmetry. The result shows that if the constraint equation is satisfied and the temperature of fluid obeys Tolmans law, the extrema of total entropy implies other components of gravitational equations. Conversely, if f ( R) gravitational equation hold, the total entropy of the fluid should be extremum. Our work suggests a general and solid connection between f ( R) gravity and thermodynamics.

  9. [General principles of effective communication between physician and patient with selected mental disorders].

    PubMed

    Błaszczyk, Justyna; Bobińska, Kinga; Filip, Maria; Gałecki, Piotr

    2015-04-01

    Faced with the growing frequency of mental disorders occurrence and considering the necessity of improving the patient care, it is particularly important that physicians of different specialties knew the general principles of effective communication with patients who are mentally ill. Equally important is to spread the knowledge of the symptomatology of various mental illnesses. Studies published by the Institute of Psychiatry and Neurology involving persons between 18 and 64 years old, show that 8 millions Poles suffers or suffered from mental disorders. This represents almost 25% of Polish society. The above data confirm, that basic knowledge of criteria for diagnosing mental disorders and their treatment by primary care physicians, determines the success of the entire health care system. It must be taken into consideration that frequently patients seeing general practitioner (GP) are suffering from more than one mental illness or it is accompanied by somatic disease. Adequate communication determines effective treatment. Simple yet exact message, ability to adapt it to patient and problems reported by him, is a valuable means in daily medical practice. It reduces the risk of iatrogenic disorder, encourages the efficiency of the entire therapeutic process. Good cooperation with the patient is also determined by patience, empathy, understanding, and competence. The aim of this study is to present the principles of effective communication between doctor and patient suffering from selected mental disorders. The article defines the concept of communication. It shows symptomatology of primary psychiatric disorders. Moreover, the most common difficulties in relationship between the doctor and the patient had been pointed.

  10. A general principle governs vision-dependent dendritic patterning of retinal ganglion cells.

    PubMed

    Xu, Hong-Ping; Sun, Jin Hao; Tian, Ning

    2014-10-15

    Dendritic arbors of retinal ganglion cells (RGCs) collect information over a certain area of the visual scene. The coverage territory and the arbor density of dendrites determine what fraction of the visual field is sampled by a single cell and at what resolution. However, it is not clear whether visual stimulation is required for the establishment of branching patterns of RGCs, and whether a general principle directs the dendritic patterning of diverse RGCs. By analyzing the geometric structures of RGC dendrites, we found that dendritic arbors of RGCs underwent a substantial spatial rearrangement after eye-opening. Light deprivation blocked both the dendritic growth and the branch patterning, suggesting that visual stimulation is required for the acquisition of specific branching patterns of RGCs. We further showed that vision-dependent dendritic growth and arbor refinement occurred mainly in the middle portion of the dendritic tree. This nonproportional growth and selective refinement suggest that the late-stage dendritic development of RGCs is not a passive stretching with the growth of eyes, but rather an active process of selective growth/elimination of dendritic arbors of RGCs driven by visual activity. Finally, our data showed that there was a power law relationship between the coverage territory and dendritic arbor density of RGCs on a cell-by-cell basis. RGCs were systematically less dense when they cover larger territories regardless of their cell type, retinal location, or developmental stage. These results suggest that a general structural design principle directs the vision-dependent patterning of RGC dendrites.

  11. General Principles for the welfare of animals in production systems: the underlying science and its application.

    PubMed

    Fraser, David; Duncan, Ian J H; Edwards, Sandra A; Grandin, Temple; Gregory, Neville G; Guyonnet, Vincent; Hemsworth, Paul H; Huertas, Stella M; Huzzey, Juliana M; Mellor, David J; Mench, Joy A; Spinka, Marek; Whay, H Rebecca

    2013-10-01

    In 2012, the World Organisation for Animal Health adopted 10 'General Principles for the Welfare of Animals in Livestock Production Systems' to guide the development of animal welfare standards. The General Principles draw on half a century of scientific research relevant to animal welfare: (1) how genetic selection affects animal health, behaviour and temperament; (2) how the environment influences injuries and the transmission of diseases and parasites; (3) how the environment affects resting, movement and the performance of natural behaviour; (4) the management of groups to minimize conflict and allow positive social contact; (5) the effects of air quality, temperature and humidity on animal health and comfort; (6) ensuring access to feed and water suited to the animals' needs and adaptations; (7) prevention and control of diseases and parasites, with humane euthanasia if treatment is not feasible or recovery is unlikely; (8) prevention and management of pain; (9) creation of positive human-animal relationships; and (10) ensuring adequate skill and knowledge among animal handlers. Research directed at animal welfare, drawing on animal behaviour, stress physiology, veterinary epidemiology and other fields, complements more established fields of animal and veterinary science and helps to create a more comprehensive scientific basis for animal care and management.

  12. Stacking Principle and Magic Sizes of Transition Metal Nanoclusters Based on Generalized Wulff Construction

    NASA Astrophysics Data System (ADS)

    Li, S. F.; Zhao, X. J.; Xu, X. S.; Gao, Y. F.; Zhang, Zhenyu

    2013-09-01

    Nanoclusters with extra stability at certain cluster sizes are known as magic clusters with exotic properties. The classic Wulff construction principle, which stipulates that the preferred structure of a cluster should minimize its total surface energy, is often invoked in determining the cluster magicity, resulting in close-shelled Mackay icosahedronal clusters with odd-numbered magic sizes of 13, 55, 147, etc. Here we use transition metal clusters around size 55 as prototypical examples to demonstrate that, in the nanometer regime, the classic Wulff construction principle needs to be generalized to primarily emphasize the edge atom effect instead of the surface energy. Specifically, our detailed calculations show that nanoclusters with much shorter total edge lengths but substantially enlarged total surface areas are energetically much more stable. As a consequence, a large majority of the nanoclusters within the 3d-, 4d-, and 5d-transition metal series are found to be fcc or hcp crystal fragments with much lower edge energies, and the widely perceived magic size of 55 is shifted to its nearby even numbers.

  13. Stacking principle and magic sizes of transition metal nanoclusters based on generalized Wulff construction.

    PubMed

    Li, S F; Zhao, X J; Xu, X S; Gao, Y F; Zhang, Zhenyu

    2013-09-13

    Nanoclusters with extra stability at certain cluster sizes are known as magic clusters with exotic properties. The classic Wulff construction principle, which stipulates that the preferred structure of a cluster should minimize its total surface energy, is often invoked in determining the cluster magicity, resulting in close-shelled Mackay icosahedronal clusters with odd-numbered magic sizes of 13, 55, 147, etc. Here we use transition metal clusters around size 55 as prototypical examples to demonstrate that, in the nanometer regime, the classic Wulff construction principle needs to be generalized to primarily emphasize the edge atom effect instead of the surface energy. Specifically, our detailed calculations show that nanoclusters with much shorter total edge lengths but substantially enlarged total surface areas are energetically much more stable. As a consequence, a large majority of the nanoclusters within the 3d-, 4d-, and 5d-transition metal series are found to be fcc or hcp crystal fragments with much lower edge energies, and the widely perceived magic size of 55 is shifted to its nearby even numbers.

  14. Robotic and mathematical modeling reveal general principles of appendage control and coordination in terrestrial locomotion

    NASA Astrophysics Data System (ADS)

    McInroe, Benjamin; Astley, Henry; Gong, Chaohui; Kawano, Sandy; Schiebel, Perrin; Choset, Howie; Goldman, Daniel I.

    The transition from aquatic to terrestrial life presented new challenges to early walkers, necessitating robust locomotion on complex, flowable substrates (e.g. sand, mud). Locomotion on such substrates is sensitive to limb morphology and kinematics. Although early walker morphologies are known, principles of appendage control remain elusive. To reveal limb control strategies that facilitated the invasion of land, we study both robotic and mathematical models. Robot experiments show that an active tail is critical for robust locomotion on granular media, enabling locomotion even with poor foot placement and limited ability to lift the body. Using a granular resistive force theory model, we construct connection vector fields that reveal how appendage coordination and terrain inclination impact locomotor performance. This model replicates experimental results, showing that moving limbs/tail in phase is most effective (suggesting a locomotor template). Varying limb trajectories and contacts, we find gaits for which tail use can be neutral or harmful, suggesting limb-tail coordination to be a nontrivial aspect of locomotion. Our findings show that robot experiments coupled with geometric mechanics provide a general framework to reveal principles of robust terrestrial locomotion. This work was supported by NSF PoLS.

  15. Enhancement of the capabilities of liquid chromatography-mass spectrometry with derivatization: general principles and applications.

    PubMed

    Xu, Fengguo; Zou, Li; Liu, Ying; Zhang, Zunjian; Ong, Choon Nam

    2011-01-01

    The integration of liquid chromatography-mass spectrometry (LC-MS) with derivatization is a relatively new and unique strategy that could add value and could enhance the capabilities of LC-MS-based technologies. The derivatization process could be carried out in various analytical steps, for example, sampling, storage, sample preparation, HPLC separation, and MS detection. This review presents an overview of derivatization-based LC-MS strategy over the past 10 years and covers both the general principles and applications in the fields of pharmaceutical and biomedical analysis, biomarker and metabolomic research, environmental analysis, and food-safety evaluation. The underlying mechanisms and theories for derivative reagent selection are summarized and highlighted to guide future studies.

  16. Galilean and Lorentz Transformations in a Space with Generalized Uncertainty Principle

    NASA Astrophysics Data System (ADS)

    Tkachuk, V. M.

    2016-07-01

    We consider a space with Generalized Uncertainty Principle (GUP) which can be obtained in the frame of the deformed commutation relations. In the space with GUP we have found transformations relating coordinates and times of moving and rest frames of reference in the first order over the parameter of deformation. In the non-relativistic case we find the deformed Galilean transformation which is rotation in Euclidian space-time. This transformation is similar to the Lorentz one but written for Euclidean space-time where the speed of light is replaced by some velocity related to the parameter of deformation. We show that for relativistic particle in the space with GUP the coordinates of the rest and moving frames of reference satisfy the Lorentz transformation with some effective speed of light.

  17. Quantum corrections to the thermodynamics of Schwarzschild-Tangherlini black hole and the generalized uncertainty principle

    NASA Astrophysics Data System (ADS)

    Feng, Z. W.; Li, H. L.; Zu, X. T.; Yang, S. Z.

    2016-04-01

    We investigate the thermodynamics of Schwarzschild-Tangherlini black hole in the context of the generalized uncertainty principle (GUP). The corrections to the Hawking temperature, entropy and the heat capacity are obtained via the modified Hamilton-Jacobi equation. These modifications show that the GUP changes the evolution of the Schwarzschild-Tangherlini black hole. Specially, the GUP effect becomes susceptible when the radius or mass of the black hole approaches the order of Planck scale, it stops radiating and leads to a black hole remnant. Meanwhile, the Planck scale remnant can be confirmed through the analysis of the heat capacity. Those phenomena imply that the GUP may give a way to solve the information paradox. Besides, we also investigate the possibilities to observe the black hole at the Large Hadron Collider (LHC), and the results demonstrate that the black hole cannot be produced in the recent LHC.

  18. [General principles of effective communication between physician and patient with selected mental disorders].

    PubMed

    Błaszczyk, Justyna; Bobińska, Kinga; Filip, Maria; Gałecki, Piotr

    2015-04-01

    Faced with the growing frequency of mental disorders occurrence and considering the necessity of improving the patient care, it is particularly important that physicians of different specialties knew the general principles of effective communication with patients who are mentally ill. Equally important is to spread the knowledge of the symptomatology of various mental illnesses. Studies published by the Institute of Psychiatry and Neurology involving persons between 18 and 64 years old, show that 8 millions Poles suffers or suffered from mental disorders. This represents almost 25% of Polish society. The above data confirm, that basic knowledge of criteria for diagnosing mental disorders and their treatment by primary care physicians, determines the success of the entire health care system. It must be taken into consideration that frequently patients seeing general practitioner (GP) are suffering from more than one mental illness or it is accompanied by somatic disease. Adequate communication determines effective treatment. Simple yet exact message, ability to adapt it to patient and problems reported by him, is a valuable means in daily medical practice. It reduces the risk of iatrogenic disorder, encourages the efficiency of the entire therapeutic process. Good cooperation with the patient is also determined by patience, empathy, understanding, and competence. The aim of this study is to present the principles of effective communication between doctor and patient suffering from selected mental disorders. The article defines the concept of communication. It shows symptomatology of primary psychiatric disorders. Moreover, the most common difficulties in relationship between the doctor and the patient had been pointed. PMID:25938394

  19. General principles and approaches to wound prevention and care at end of life: an overview .

    PubMed

    Langemo, Diane

    2012-05-01

    The incidence and prevalence of wounds in persons at the end of life is largely unknown, but wounds are estimated to occur in at least one third of hospice patients. At the end of life, healthcare professionals must help the patient and/ or family decide whether the goals of wound prevention and care should focus on healing or palliation. At all times, it is important to consider that a palliative approach does not negate the potential for wound improvement or even closing before death. A review of the literature suggests that, in general, few differences exist between the general principles of wound prevention and care and an optimal palliative care plan. For example, maintenance of a moist wound environment is recommended to facilitate healing in general protocols of care. In end-of-life patients, dressings should be used for general comfort and prevention of skin exposure to wound exudate and to reduce the number of potentially painful dressing changes. Risk factors for tissue breakdown and pressure ulcer development are also similar. Palliative care patients with limited mobility and physical activity are at highest risk for developing pressure ulcers, but measures to help prevent these wounds may have to be adjusted to meet the overall goals of palliative care for a particular patient. Wounds encountered mainly in cancer patients - eg, fungating and radiation wounds - can pose important challenges for healthcare professionals and are very stressful for the patient. Pressure ulcers, fungating, and radiation wounds at the end of life are to be managed palliatively with the overall goal to minimize pain and odor, enhance comfort, and potentially improve the condition of the ulcer. Although research remains limited, it is clear the clinician and patient must balance best wound prevention and management practices while promoting patient dignity, self-esteem, and quality of life.

  20. General properties on applying the principle of minimum sensitivity to high-order perturbative QCD predictions

    NASA Astrophysics Data System (ADS)

    Ma, Yang; Wu, Xing-Gang; Ma, Hong-Hao; Han, Hua-Yong

    2015-02-01

    As one of the key components of perturbative QCD theory, it is helpful to find a systematic and reliable way to set the renormalization scale for a high-energy process. The conventional treatment is to take a typical momentum as the renormalization scale, which assigns an arbitrary range and an arbitrary systematic error to pQCD predictions, leading to the well-known renormalization scheme and scale ambiguities. As a practical solution for such a scale setting problem, the "principle of minimum sensitivity" (PMS) has been proposed in the literature. The PMS suggests to determine an optimal scale for the pQCD approximant of an observable by requiring its slope over the scheme and scale changes to vanish. In this paper, we present a detailed discussion on general properties of the PMS by utilizing three quantities Re+e-, Rτ and Γ (H →b b ¯) up to four-loop QCD corrections. After applying the PMS, the accuracy of pQCD prediction, the pQCD convergence, the pQCD predictive power, etc., are discussed. Furthermore, we compare the PMS with another fundamental scale setting approach, i.e. the principle of maximum conformality (PMC). The PMC is theoretically sound, which follows the renormalization group equation to determine the running behavior of the coupling constant and satisfies the standard renormalization group invariance. Our results show that PMS does provide a practical way to set the effective scale for high-energy process, and the PMS prediction agrees with the PMC one by including enough high-order QCD corrections, both of which shall be more accurate than the prediction under the conventional scale setting. However, the PMS pQCD convergence is an accidental, which usually fails to achieve a correct prediction of unknown high-order contributions with next-to-leading order QCD correction only, i.e. it is always far from the "true" values predicted by including more high-order contributions.

  1. Utilization of the seven principles for good practice in undergraduate education in general chemistry by community college instructors

    NASA Astrophysics Data System (ADS)

    Panther Bishoff, Jennifer

    In recent years, higher education has undergone many changes. The advent of assessment, accountability, and a newfound focus on teaching have required faculty to examine how they are teaching. Administrators and faculty are beginning to recognize that learning is not a "one size fits all" enterprise. To this end, Chickering and Gamson developed an inventory that examined faculty utilization of the Seven Principles of Good Practice in Undergraduate Education. The seven principles included by the authors included faculty-student interaction, cooperative learning, active learning, giving prompt feedback, emphasizing time on task, communicating high expectations, and respecting diverse talents and ways of learning. It was determined by Chickering and Gamson, as well as many other researchers, that these seven principles were hallmarks of successful undergraduate education. Community colleges are important institutions to study, as many students begin their higher education at two-year colleges. Most students are also required to take one or more science classes for their general education requirements; therefore, many students must take at least one general chemistry course. Both community colleges and chemistry are rarely studied in literature, which makes this study important. Community college general chemistry instructors were surveyed using an online version of Chickering and Gamson's Faculty Inventory for the Seven Principles of Good Practice in Undergraduate Education. Responses were analyzed, and it was discovered that not only did instructors utilize the principles to a different extent, but there were also differences between genders as well as between the specific actions related to each principle.

  2. Elucidating the general principles of cell adhesion with a coarse-grained simulation model.

    PubMed

    Chen, Jiawen; Xie, Zhong-Ru; Wu, Yinghao

    2016-01-01

    Cell adhesion plays an indispensable role in coordinating physiological functions in multicellular organisms. During this process, specific types of cell adhesion molecules interact with each other from the opposite sides of neighboring cells. Following this trans-interaction, many cell adhesion molecules further aggregate into clusters through cis interactions. Beyond the molecule level, adhesion can be affected by multiple cellular factors due to the complexity of membrane microenvironments, including its interplay with cell signaling. However, despite tremendous advances in experimental developments, little is understood about the general principles of cell adhesion and its functional impacts. Here a mesoscopic simulation method is developed to tackle this problem. We illustrated that specific spatial patterns of membrane protein clustering are originated from different geometrical arrangements of their binding interfaces, while the size of clusters is closely regulated by molecular flexibility. Different scenarios of cooperation between trans and cis interactions of cell adhesion molecules were further tested. Additionally, impacts of membrane environments on cell adhesion were evaluated, such as the presence of a cytoskeletal meshwork, the membrane tension and the size effect of different membrane proteins on cell surfaces. Finally, by simultaneously simulating adhesion and oligomerization of signaling receptors, we found that the interplay between these two systems can be either positive or negative, closely depending on the spatial and temporal patterns of their molecular interactions. Therefore, our computational model pave the way for understanding the molecular mechanisms of cell adhesion and its biological functions in regulating cell signaling pathways.

  3. Pleasure and pain: teaching neuroscientific principles of hedonism in a large general education undergraduate course.

    PubMed

    Bodnar, Richard J; Stellar, James R; Kraft, Tamar T; Loiacono, Ilyssa; Bajnath, Adesh; Rotella, Francis M; Barrientos, Alicia; Aghanori, Golshan; Olsson, Kerstin; Coke, Tricia; Huang, Donald; Luger, Zeke; Mousavi, Seyed Ali Reza; Dindyal, Trisha; Naqvi, Naveen; Kim, Jung-Yo

    2013-01-01

    In a large (250 registrants) general education lecture course, neuroscience principles were taught by two professors as co-instructors, starting with simple brain anatomy, chemistry, and function, proceeding to basic brain circuits of pleasure and pain, and progressing with fellow expert professors covering relevant philosophical, artistic, marketing, and anthropological issues. With this as a base, the course wove between fields of high relevance to psychology and neuroscience, such as food addiction and preferences, drug seeking and craving, analgesic pain-inhibitory systems activated by opiates and stress, neuroeconomics, unconscious decision-making, empathy, and modern neuroscientific techniques (functional magnetic resonance imaging and event-related potentials) presented by the co-instructors and other Psychology professors. With no formal assigned textbook, all lectures were PowerPoint-based, containing links to supplemental public-domain material. PowerPoints were available on Blackboard several days before the lecture. All lectures were also video-recorded and posted that evening. The course had a Facebook page for after-class conversation and one of the co-instructors communicated directly with students on Twitter in real time during lecture to provide momentary clarification and comment. In addition to graduate student Teaching Assistants (TAs), to allow for small group discussion, ten undergraduate students who performed well in a previous class were selected to serve as discussion leaders. The Discussion Leaders met four times at strategic points over the semester with groups of 20-25 current students, and received one credit of Independent Study, thus creating a course within a course. The course grade was based on weighted scores from two multiple-choice exams and a five-page writing assignment in which each student reviewed three unique, but brief original peer-review research articles (one page each) combined with expository writing on the first

  4. Pleasure and Pain: Teaching Neuroscientific Principles of Hedonism in a Large General Education Undergraduate Course

    PubMed Central

    Bodnar, Richard J.; Stellar, James R.; Kraft, Tamar T.; Loiacono, Ilyssa; Bajnath, Adesh; Rotella, Francis M.; Barrientos, Alicia; Aghanori, Golshan; Olsson, Kerstin; Coke, Tricia; Huang, Donald; Luger, Zeke; Mousavi, Seyed Ali Reza; Dindyal, Trisha; Naqvi, Naveen; Kim, Jung-Yo

    2013-01-01

    In a large (250 registrants) general education lecture course, neuroscience principles were taught by two professors as co-instructors, starting with simple brain anatomy, chemistry, and function, proceeding to basic brain circuits of pleasure and pain, and progressing with fellow expert professors covering relevant philosophical, artistic, marketing, and anthropological issues. With this as a base, the course wove between fields of high relevance to psychology and neuroscience, such as food addiction and preferences, drug seeking and craving, analgesic pain-inhibitory systems activated by opiates and stress, neuroeconomics, unconscious decision-making, empathy, and modern neuroscientific techniques (functional magnetic resonance imaging and event-related potentials) presented by the co-instructors and other Psychology professors. With no formal assigned textbook, all lectures were PowerPoint-based, containing links to supplemental public-domain material. PowerPoints were available on Blackboard several days before the lecture. All lectures were also video-recorded and posted that evening. The course had a Facebook page for after-class conversation and one of the co-instructors communicated directly with students on Twitter in real time during lecture to provide momentary clarification and comment. In addition to graduate student Teaching Assistants (TAs), to allow for small group discussion, ten undergraduate students who performed well in a previous class were selected to serve as discussion leaders. The Discussion Leaders met four times at strategic points over the semester with groups of 20–25 current students, and received one credit of Independent Study, thus creating a course within a course. The course grade was based on weighted scores from two multiple-choice exams and a five-page writing assignment in which each student reviewed three unique, but brief original peer-review research articles (one page each) combined with expository writing on the first

  5. Pleasure and pain: teaching neuroscientific principles of hedonism in a large general education undergraduate course.

    PubMed

    Bodnar, Richard J; Stellar, James R; Kraft, Tamar T; Loiacono, Ilyssa; Bajnath, Adesh; Rotella, Francis M; Barrientos, Alicia; Aghanori, Golshan; Olsson, Kerstin; Coke, Tricia; Huang, Donald; Luger, Zeke; Mousavi, Seyed Ali Reza; Dindyal, Trisha; Naqvi, Naveen; Kim, Jung-Yo

    2013-01-01

    In a large (250 registrants) general education lecture course, neuroscience principles were taught by two professors as co-instructors, starting with simple brain anatomy, chemistry, and function, proceeding to basic brain circuits of pleasure and pain, and progressing with fellow expert professors covering relevant philosophical, artistic, marketing, and anthropological issues. With this as a base, the course wove between fields of high relevance to psychology and neuroscience, such as food addiction and preferences, drug seeking and craving, analgesic pain-inhibitory systems activated by opiates and stress, neuroeconomics, unconscious decision-making, empathy, and modern neuroscientific techniques (functional magnetic resonance imaging and event-related potentials) presented by the co-instructors and other Psychology professors. With no formal assigned textbook, all lectures were PowerPoint-based, containing links to supplemental public-domain material. PowerPoints were available on Blackboard several days before the lecture. All lectures were also video-recorded and posted that evening. The course had a Facebook page for after-class conversation and one of the co-instructors communicated directly with students on Twitter in real time during lecture to provide momentary clarification and comment. In addition to graduate student Teaching Assistants (TAs), to allow for small group discussion, ten undergraduate students who performed well in a previous class were selected to serve as discussion leaders. The Discussion Leaders met four times at strategic points over the semester with groups of 20-25 current students, and received one credit of Independent Study, thus creating a course within a course. The course grade was based on weighted scores from two multiple-choice exams and a five-page writing assignment in which each student reviewed three unique, but brief original peer-review research articles (one page each) combined with expository writing on the first

  6. Precautionary Principles: General Definitions and Specific Applications to Genetically Modified Organisms

    ERIC Educational Resources Information Center

    Lofstedt, Ragnar E.; Fischhoff, Baruch; Fischhoff, Ilya R.

    2002-01-01

    Precautionary principles have been proposed as a fundamental element of sound risk management. Their advocates see them as guiding action in the face of uncertainty, encouraging the adoption of measures that reduce serious risks to health, safety, and the environment. Their opponents may reject the very idea of precautionary principles, find…

  7. 2 CFR Appendix A to Part 225 - General Principles for Determining Allowable Costs

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Contents A. Purpose and Scope 1. Objectives 2. Policy guides 3. Application B. Definitions 1. Approval or... appendix and other appendices to 2 CFR part 225 as “Federal awards”). The principles are for the purpose of... is outside the scope of 2 CFR part 225. 2. Policy guides. a. The application of these principles...

  8. Phase-space-Lagrangian action principle and the generalized K-X theorem. [in covariant coupled equations for plasma dynamics

    NASA Technical Reports Server (NTRS)

    Kaufman, Allan N.

    1987-01-01

    The covariant coupled equations for plasma dynamics and the Maxwell field are expressed as a phase-space-Lagrangian action principle. The linear interaction is transformed to the bilinear beat Hamiltonian by a gauge-invariant Lagrangian Lie transform. The result yields the generalized linear susceptibility directly.

  9. NSF workshop report: discovering general principles of nervous system organization by comparing brain maps across species.

    PubMed

    Striedter, Georg F; Belgard, T Grant; Chen, Chun-Chun; Davis, Fred P; Finlay, Barbara L; Güntürkün, Onur; Hale, Melina E; Harris, Julie A; Hecht, Erin E; Hof, Patrick R; Hofmann, Hans A; Holland, Linda Z; Iwaniuk, Andrew N; Jarvis, Erich D; Karten, Harvey J; Katz, Paul S; Kristan, William B; Macagno, Eduardo R; Mitra, Partha P; Moroz, Leonid L; Preuss, Todd M; Ragsdale, Clifton W; Sherwood, Chet C; Stevens, Charles F; Stüttgen, Maik C; Tsumoto, Tadaharu; Wilczynski, Walter

    2014-05-01

    Efforts to understand nervous system structure and function have received new impetus from the federal Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative. Comparative analyses can contribute to this effort by leading to the discovery of general principles of neural circuit design, information processing, and gene-structure-function relationships that are not apparent from studies on single species. We here propose to extend the comparative approach to nervous system 'maps' comprising molecular, anatomical, and physiological data. This research will identify which neural features are likely to generalize across species, and which are unlikely to be broadly conserved. It will also suggest causal relationships between genes, development, adult anatomy, physiology, and, ultimately, behavior. These causal hypotheses can then be tested experimentally. Finally, insights from comparative research can inspire and guide technological development. To promote this research agenda, we recommend that teams of investigators coalesce around specific research questions and select a set of 'reference species' to anchor their comparative analyses. These reference species should be chosen not just for practical advantages, but also with regard for their phylogenetic position, behavioral repertoire, well-annotated genome, or other strategic reasons. We envision that the nervous systems of these reference species will be mapped in more detail than those of other species. The collected data may range from the molecular to the behavioral, depending on the research question. To integrate across levels of analysis and across species, standards for data collection, annotation, archiving, and distribution must be developed and respected. To that end, it will help to form networks or consortia of researchers and centers for science, technology, and education that focus on organized data collection, distribution, and training. These activities could be supported

  10. NSF workshop report: discovering general principles of nervous system organization by comparing brain maps across species.

    PubMed

    Striedter, Georg F; Belgard, T Grant; Chen, Chun-Chun; Davis, Fred P; Finlay, Barbara L; Güntürkün, Onur; Hale, Melina E; Harris, Julie A; Hecht, Erin E; Hof, Patrick R; Hofmann, Hans A; Holland, Linda Z; Iwaniuk, Andrew N; Jarvis, Erich D; Karten, Harvey J; Katz, Paul S; Kristan, William B; Macagno, Eduardo R; Mitra, Partha P; Moroz, Leonid L; Preuss, Todd M; Ragsdale, Clifton W; Sherwood, Chet C; Stevens, Charles F; Stüttgen, Maik C; Tsumoto, Tadaharu; Wilczynski, Walter

    2014-01-01

    Efforts to understand nervous system structure and function have received new impetus from the federal Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative. Comparative analyses can contribute to this effort by leading to the discovery of general principles of neural circuit design, information processing, and gene-structure-function relationships that are not apparent from studies on single species. We here propose to extend the comparative approach to nervous system 'maps' comprising molecular, anatomical, and physiological data. This research will identify which neural features are likely to generalize across species, and which are unlikely to be broadly conserved. It will also suggest causal relationships between genes, development, adult anatomy, physiology, and, ultimately, behavior. These causal hypotheses can then be tested experimentally. Finally, insights from comparative research can inspire and guide technological development. To promote this research agenda, we recommend that teams of investigators coalesce around specific research questions and select a set of 'reference species' to anchor their comparative analyses. These reference species should be chosen not just for practical advantages, but also with regard for their phylogenetic position, behavioral repertoire, well-annotated genome, or other strategic reasons. We envision that the nervous systems of these reference species will be mapped in more detail than those of other species. The collected data may range from the molecular to the behavioral, depending on the research question. To integrate across levels of analysis and across species, standards for data collection, annotation, archiving, and distribution must be developed and respected. To that end, it will help to form networks or consortia of researchers and centers for science, technology, and education that focus on organized data collection, distribution, and training. These activities could be supported

  11. 77 FR 7125 - Codex Alimentarius Commission: Meeting of the Codex Committee on General Principles

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-10

    ... Principles (CCGP) of the Codex Alimentarius Commission (Codex), which will be held in Paris, France, April 2... Committee is hosted by France. Issues To Be Discussed at the Public Meeting The following items on...

  12. Generalization of Abel's mechanical problem: The extended isochronicity condition and the superposition principle

    SciTech Connect

    Kinugawa, Tohru

    2014-02-15

    This paper presents a simple but nontrivial generalization of Abel's mechanical problem, based on the extended isochronicity condition and the superposition principle. There are two primary aims. The first one is to reveal the linear relation between the transit-time T and the travel-length X hidden behind the isochronicity problem that is usually discussed in terms of the nonlinear equation of motion (d{sup 2}X)/(dt{sup 2}) +(dU)/(dX) =0 with U(X) being an unknown potential. Second, the isochronicity condition is extended for the possible Abel-transform approach to designing the isochronous trajectories of charged particles in spectrometers and/or accelerators for time-resolving experiments. Our approach is based on the integral formula for the oscillatory motion by Landau and Lifshitz [Mechanics (Pergamon, Oxford, 1976), pp. 27–29]. The same formula is used to treat the non-periodic motion that is driven by U(X). Specifically, this unknown potential is determined by the (linear) Abel transform X(U) ∝ A[T(E)], where X(U) is the inverse function of U(X), A=(1/√(π))∫{sub 0}{sup E}dU/√(E−U) is the so-called Abel operator, and T(E) is the prescribed transit-time for a particle with energy E to spend in the region of interest. Based on this Abel-transform approach, we have introduced the extended isochronicity condition: typically, τ = T{sub A}(E) + T{sub N}(E) where τ is a constant period, T{sub A}(E) is the transit-time in the Abel type [A-type] region spanning X > 0 and T{sub N}(E) is that in the Non-Abel type [N-type] region covering X < 0. As for the A-type region in X > 0, the unknown inverse function X{sub A}(U) is determined from T{sub A}(E) via the Abel-transform relation X{sub A}(U) ∝ A[T{sub A}(E)]. In contrast, the N-type region in X < 0 does not ensure this linear relation: the region is covered with a predetermined potential U{sub N}(X) of some arbitrary choice, not necessarily obeying the Abel-transform relation. In discussing

  13. 2 CFR Appendix A to Part 225 - General Principles for Determining Allowable Costs

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... with the Federal Government (collectively referred to in this appendix and other appendices to 2 CFR... in the financing of a particular program or project. The principles are designed to provide that... prohibited by law. Provision for profit or other increment above cost is outside the scope of 2 CFR part...

  14. [General principles of clinical and therapeutic management in postoperative external enteral fistulas].

    PubMed

    Munteanu, Iulia; Stefan, S; Burcoveanu, C; Pădureanu, S; Bulat, C

    2008-01-01

    Postoperative enterocutaneous fistulas represent a frequent complication in the emergency or cancerous digestive surgery. As to the high level of mortality and morbidity caused by this type of postoperative complication (4%), efforts are made to establish the principles of therapeutic management, on the purpose of decreasing these indicators and thus lowering the prolonged hospitalisation afferent costs. PMID:20201248

  15. The linear co-variance between joint muscle torques is not a generalized principle.

    PubMed

    Sande de Souza, Luciane Aparecida Pascucci; Dionísio, Valdeci Carlos; Lerena, Mario Adrian Misailidis; Marconi, Nadia Fernanda; Almeida, Gil Lúcio

    2009-06-01

    In 1996, Gottlieb et al. [Gottlieb GL, Song Q, Hong D, Almeida GL, Corcos DM. Coordinating movement at two joints: A principle of linear covariance. J Neurophysiol 1996;75(4):1760-4] identified a linear co-variance between the joint muscle torques generated at two connected joints. The joint muscle torques changed directions and magnitudes in a synchronized and linear fashion and called it the principle of linear co-variance. Here we showed that this principle cannot hold for some class of movements. Neurologically normal subjects performed multijoint movements involving elbow and shoulder with reversal towards three targets in the sagittal plane without any constraints. The movement kinematics was calculated using the X and Y coordinates of the markers positioned over the joints. Inverse dynamics was used to calculate the joint muscle, interaction and net torques. We found that for the class of voluntary movements analyzed, the joint muscle torques of the elbow and the shoulder were not linearly correlated. The same was observed for the interaction torques. But, the net torques at both joints, i.e., the sum of the interaction and the joint muscle torques were linearly correlated. We showed that by decoupling the joint muscle torques, but keeping the net torques linearly correlated, the CNS was able to generate fast and accurate movements with straight fingertip paths. The movement paths were typical of the ones in which the joint muscle torques were linearly correlated.

  16. Wave function formalism in quantum optics and generalized Huygens-Fresnel principle for N-photon states: derivation and applications

    NASA Astrophysics Data System (ADS)

    Brainis, E.; Emplit, Ph.

    2010-06-01

    Few-photon systems are best described by their wave function rather than by the usual quantum field formalism. In this work, we develop a photon wave function (PWF) formalism suitable for analyzing a wide variety of quantum optical problems related to propagation, diffraction and imaging with quantum states of light. We establish a generalized Huygens-Fresnel (GH-F) principle that describes the propagation of any paraxial N-photon state. This tool is very helpful for predicting photo-detection correlations in space and time due to an initial N-particle entanglement, even in complex situation. The effect of lenses, beam splitters, filters ... on the photon paths can be easily taken into account. We apply the PWF formalism and the GH-F principle to three specific problems in quantum optics. First, we revisit the Hong-Ou-Mandel two-photon interference effect and analyze the effect of photon shape mismatch in space, time and polarization using the PWF formalism. Second, we show how to use the GH-F principle to analyze "ghost" imaging and diffraction experiments with entangled photon pairs such as those realized by Strekalov et al. [Phys. Rev. Lett. 74, 3600 (1995)] and Pittman et al. [Phys. Rev. A 52, R3429 (1995)] in the nineties. Finally, we use the GH-F principle to analyze the resolution enhancement in a recent quantum imaging proposal based on N incoherent single-photon sources [Phys. Rev. Lett. 99, 133603 (2007) and Phys. Rev. A 80, 013820 (2009)].

  17. Quantum statistical entropy and minimal length of 5D Ricci-flat black string with generalized uncertainty principle

    SciTech Connect

    Liu Molin; Gui Yuanxing; Liu Hongya

    2008-12-15

    In this paper, we study the quantum statistical entropy in a 5D Ricci-flat black string solution, which contains a 4D Schwarzschild-de Sitter black hole on the brane, by using the improved thin-layer method with the generalized uncertainty principle. The entropy is the linear sum of the areas of the event horizon and the cosmological horizon without any cutoff and any constraint on the bulk's configuration rather than the usual uncertainty principle. The system's density of state and free energy are convergent in the neighborhood of horizon. The small-mass approximation is determined by the asymptotic behavior of metric function near horizons. Meanwhile, we obtain the minimal length of the position {delta}x, which is restrained by the surface gravities and the thickness of layer near horizons.

  18. General Principles for Measuring Resting Membrane Potential and Ion Concentration Using Fluorescent Bioelectricity Reporters

    PubMed Central

    Adams, Dany Spencer; Levin, Michael

    2014-01-01

    This overview provides the basic information needed to understand, choose, and use fluorescent bioelectricity reporters (FBRs), where bioelectricity is defined as cell processes that involve ions or ion flux. While traditional methods of measuring these characteristics are still valid and necessary, the utility of FBRs has facilitated measurement of these properties under circumstances that are not possible with microelectrodes. Specifically, these dyes can be used to achieve subcellular resolution, to measure many cells simultaneously in vivo, and to track bioelectric gradients over long time periods despite cell movements and divisions. This article covers the basic principles underlying the interpretation of the dye signals, describes essential steps for troubleshooting, optimizing data collection, analysis, and presentation, and provides compilations of information that are useful for choosing FBRs for particular projects. PMID:22474653

  19. Water, Resilience and the Law: From General Concepts and Governance Design Principles to Actionable Mechanisms

    NASA Astrophysics Data System (ADS)

    Hill Clarvis, M.; Allan, A.; Hannah, D. M.

    2013-12-01

    Climate change has significant ramifications for water law and governance, yet, there is strong evidence that legal regulations have often failed to protect environments or promote sustainable development. Scholars have increasingly suggested that the preservation and restoration paradigms of legislation and regulation are no longer adequate for climate change related challenges in complex and cross-scale social-ecological systems. This is namely due to past assumptions of stationarity, uniformitarianism and the perception of ecosystem change as predictable and reversible. This paper reviews the literature on law and resilience and then presents and discusses a set of practical examples of legal mechanisms from the water resources management sector, identified according to a set of guiding principles from the literature on adaptive capacity, adaptive governance as well as adaptive and integrated water resources management. It then assesses the aptness of these different measures according to scientific evidence of increased uncertainty and changing ecological baselines. A review of the best practice examples demonstrates that there are a number of best practice examples attempting to integrate adaptive elements of flexibility, iterativity, connectivity and subsidiarity into a variety of legislative mechanisms, suggesting that there is not as significant a tension between resilience and the law as many scholars have suggested. However, while many of the mechanisms may indeed be suitable for addressing challenges relating to current levels of change and uncertainty, analysis across a broader range of uncertainty highlights challenges relating to more irreversible changes associated with greater levels of warming. Furthermore the paper identifies a set of pre-requisites that are fundamental to the successful implementation of such mechanisms, namely monitoring and data sharing, financial and technical capacity, particularly in nations that are most at risk with the

  20. General Education for the 21st Century: A Quest for Common Principles

    ERIC Educational Resources Information Center

    Word, Andrea

    2012-01-01

    In the early years of the 21st century, general education programs in U.S. postsecondary institutions stand at the center of multiple competing pressures, from demands for accountability to calls for increasing assurances of articulation across institutions. Complicating potential responses to these normative pressures is the challenge inherent in…

  1. Extending the generality of leaf economic design principles in the cycads, an ancient lineage.

    PubMed

    Zhang, Yong-Jiang; Cao, Kun-Fang; Sack, Lawren; Li, Nan; Wei, Xue-Mei; Goldstein, Guillermo

    2015-04-01

    Cycads are the most ancient lineage of living seed plants, but the design of their leaves has received little study. We tested whether cycad leaves are governed by the same fundamental design principles previously established for ferns, conifers and angiosperms, and characterized the uniqueness of this relict lineage in foliar trait relationships. Leaf structure, photosynthesis, hydraulics and nutrient composition were studied in 33 cycad species from nine genera and three families growing in two botanical gardens. Cycads varied greatly in leaf structure and physiology. Similarly to other lineages, light-saturated photosynthetic rate per mass (Am ) was related negatively to leaf mass per area and positively to foliar concentrations of chlorophyll, nitrogen (N), phosphorus and iron, but unlike angiosperms, leaf photosynthetic rate was not associated with leaf hydraulic conductance. Cycads had lower photosynthetic N use efficiency and higher photosynthetic performance relative to hydraulic capacity compared with other lineages. These findings extend the relationships shown for foliar traits in angiosperms to the cycads. This functional convergence supports the modern synthetic understanding of leaf design, with common constraints operating across lineages, even as they highlight exceptional aspects of the biology of this key relict lineage. PMID:25622799

  2. Finding simplicity in complexity: general principles of biological and nonbiological organization.

    PubMed

    Perez Velazquez, Jose L

    2009-08-01

    What differentiates the living from the nonliving? What is life? These are perennial questions that have occupied minds since the beginning of cultures. The search for a clear demarcation between animate and inanimate is a reflection of the human tendency to create borders, not only physical but also conceptual. It is obvious that what we call a living creature, either bacteria or organism, has distinct properties from those of the normally called nonliving. However, searching beyond dichotomies and from a global, more abstract, perspective on natural laws, a clear partition of matter into animate and inanimate becomes fuzzy. Based on concepts from a variety of fields of research, the emerging notion is that common principles of biological and nonbiological organization indicate that natural phenomena arise and evolve from a central theme captured by the process of information exchange. Thus, a relatively simple universal logic that rules the evolution of natural phenomena can be unveiled from the apparent complexity of the natural world. PMID:19669573

  3. [General principles of handling tissues and organs intended for examination in histopathology - pathologists requirements for surgeons].

    PubMed

    Trnková, M

    2014-03-01

    Histopathology has continued to develop into a complex discipline of laboratory medicine in the last 30 years. Implementation of new techniques such as immunohistochemistry, in situ hybridization, molecular pathology and gene profiling yields a large amount of information which is used not only to establish diagnosis, but also for prediction and prognosis. The basic conditions for precision and correctness of this information which directly influence the choice of therapy and the outcome for the patient, and eventually the health and the life of the patient, are obtaining a suitable specimen and the best laboratory processing. The first step in this procedure is collection of samples, fixation and submission to the pathology laboratory - the pre-analytical phase. Knowledge of the principles of this phase and their implementation in daily practice in surgery is of main importance for the quality and quantity of information obtained. We introduce the basic rules for proper handling of different specimens depending on the use of conventional and "new" histopathology methods.

  4. Extending the generality of leaf economic design principles in the cycads, an ancient lineage.

    PubMed

    Zhang, Yong-Jiang; Cao, Kun-Fang; Sack, Lawren; Li, Nan; Wei, Xue-Mei; Goldstein, Guillermo

    2015-04-01

    Cycads are the most ancient lineage of living seed plants, but the design of their leaves has received little study. We tested whether cycad leaves are governed by the same fundamental design principles previously established for ferns, conifers and angiosperms, and characterized the uniqueness of this relict lineage in foliar trait relationships. Leaf structure, photosynthesis, hydraulics and nutrient composition were studied in 33 cycad species from nine genera and three families growing in two botanical gardens. Cycads varied greatly in leaf structure and physiology. Similarly to other lineages, light-saturated photosynthetic rate per mass (Am ) was related negatively to leaf mass per area and positively to foliar concentrations of chlorophyll, nitrogen (N), phosphorus and iron, but unlike angiosperms, leaf photosynthetic rate was not associated with leaf hydraulic conductance. Cycads had lower photosynthetic N use efficiency and higher photosynthetic performance relative to hydraulic capacity compared with other lineages. These findings extend the relationships shown for foliar traits in angiosperms to the cycads. This functional convergence supports the modern synthetic understanding of leaf design, with common constraints operating across lineages, even as they highlight exceptional aspects of the biology of this key relict lineage.

  5. The effect of generalized uncertainty principle on square well, a case study

    SciTech Connect

    Ma, Meng-Sen; Zhao, Ren

    2014-08-15

    According to a special case (β = 0) of the generalized uncertainty relation we derive the energy eigenvalues of the infinite potential well. It is shown that the obtained energy levels are different from the usual result with some correction terms. And the correction terms of the energy eigenvalues are independent of other parameters except α. But the eigenstates will depend on another two parameters besides α.

  6. A Z{sub 3} generalization of Pauli's principle, quark algebra and the Lorentz invariance

    SciTech Connect

    Kerner, Richard

    2012-09-24

    The fundamental difference between bosons and fermions is that they obey two alternative representations of the Z{sub 2} group, resulting in symmetric or anti-symmetric binary commutation relations. Our aim is to explore possibilities offered by ternary Z{sub 3} generalization commutation relations. This leads to cubic and ternary algebras which are a direct generalization of usual commutation relations, with Z{sub 3}-grading replacing the usual Z{sub 2}-grading. Properties and structure of such algebras are discussed, with special interest in a low-dimensional one, with two generators. Invariant cubic forms on such algebras are introduced, and it is shown how the SL(2,C) group arises naturally as the symmetry group preserving these forms. In the case of lowest dimension, with only two generators, it is shown how the cubic combinations of elements of the same Z{sub 3} grade behave like Lorentz spinors, while binary products of elements of this algebra with an element of the conjugate algebra behave like Lorentz vectors. The wave equation generalizing the Dirac operator to the Z{sub 3}-graded case is introduced, whose diagonalization leads to a third-order equation. The solutions of this equation cannot propagate because their exponents always contain non-oscillating real damping factor. We show how certain cubic products can propagate nevertheless. The model suggests the origin of the color SU(3) symmetry obeyed by quark states.

  7. On extracting design principles from biology: I. Method-General answers to high-level design questions for bioinspired robots.

    PubMed

    Haberland, M; Kim, S

    2015-02-02

    When millions of years of evolution suggest a particular design solution, we may be tempted to abandon traditional design methods and copy the biological example. However, biological solutions do not often translate directly into the engineering domain, and even when they do, copying eliminates the opportunity to improve. A better approach is to extract design principles relevant to the task of interest, incorporate them in engineering designs, and vet these candidates against others. This paper presents the first general framework for determining whether biologically inspired relationships between design input variables and output objectives and constraints are applicable to a variety of engineering systems. Using optimization and statistics to generalize the results beyond a particular system, the framework overcomes shortcomings observed of ad hoc methods, particularly those used in the challenging study of legged locomotion. The utility of the framework is demonstrated in a case study of the relative running efficiency of rotary-kneed and telescoping-legged robots.

  8. [General principles of treatment of mine-explosive wounds of ENT-organs].

    PubMed

    Beliakin, S A; Egorov, V I; Luk'ianenko, A V

    2011-11-01

    The relevance of diagnosis and treatment of mine-explosive wounds ENT high. Treatment of explosives, Russian Academy of Sciences-the challenge and consists of a series of sequential steps that need to be applied, taking into account all the particularities of each injury. Concepts of specialized surgical care of the wounded are formulated. The main are: 1) one-stage surgical treatment of comprehensive primary wounds with detent of bone fragments, reconstruction of defects of soft tissue with positive wound and related fascial spatium drainage; 2) general intensive care during the postoperative period, including water-electrolytic balance correction, sympathetic block, controlled hemodilution and adequate analgesia; 3) intensive therapy of postoperative wounds, aimed at creating favorable conditions for its healing and includes targeted selective influence on hemophoresis in the wound and the local proteoclastic processes.

  9. River and Wetland Food Webs in Australia's Wet-Dry Tropics: General Principles and Implications for Management.

    NASA Astrophysics Data System (ADS)

    Douglas, M. M.; Bunn, S. E.; Davies, P. M.

    2005-05-01

    The tropical rivers of northern Australia are internationally recognised for their high ecological and cultural values. They have largely unmodified flow regimes and are comparatively free of the impacts associated with intensive land use. However, there is growing demand for agricultural development and existing pressures, such as weeds and feral animals, threaten their ecological integrity. Using the international literature to provide a conceptual framework and drawing on limited published and unpublished data on rivers in northern Australia, we have derived five general principles about food webs and related ecosystem processes that both characterise tropical rivers of northern Australia and have important implications for their management. These are: (1) Seasonal hydrology is a strong driver of ecosystem processes and food web structure; (2) Hydrological connectivity is largely intact and underpins important terrestrial-aquatic food web subsidies; (3) River and wetland food webs are strongly dependent on algal production; (4) A few common macroconsumers species have a strong influence on benthic food webs; (5) Omnivory is widespread and food chains are short. These principles have implications for the management and protection of tropical rivers and wetlands of northern Australia and provide a framework for the formation of testable hypotheses in future research programs.

  10. Over-constraints and a unified mobility method for general spatial mechanisms Part 2: Application of the principle

    NASA Astrophysics Data System (ADS)

    Lu, Wenjuan; Zeng, Daxing; Huang, Zhen

    2016-01-01

    The pre-research on mobility analysis presented a unified-mobility formula and a methodology based on reciprocal screw theory by HUANG, which focused on classical and modern parallel mechanisms. However its range of application needs to further extend to general multi-loop spatial mechanism. This kind of mechanism is not only more complex in structure but also with strong motion coupling among loops, making the mobility analysis even more complicated, and the relevant research has long been ignored. It is focused on how to apply the new principle for general spatial mechanism to those various multi-loop spatial mechanisms, and some new meaningful knowledge is further found. Several typical examples of the general multi-loop spatial mechanisms with motion couple even strong motion couple are considered. These spatial mechanisms include different closing way: over-constraint appearing in rigid closure, in movable closure, and in dynamic closure as well; these examples also include two different new methods to solve this kind of issue: the way to recognize over-constraints by analyzing relative movement between two connected links and by constructing a virtual loop to recognize over-constraints. In addition, over-constraint determination tabulation is brought to analyze the motion couple. The researches above are all based upon the screw theory. All these multi-loop spatial mechanisms with different kinds of structures can completely be solved by following the directions and examples, and the new mobility theory based on the screw theory is also proved to be valid. This study not only enriches and develops the theory and makes the theory more universal, but also has a special meaning for innovation in mechanical engineering.

  11. Foreign Literature at the Lessons of Individual Reading: Contemporary Methods of Phraseological Units Teaching

    ERIC Educational Resources Information Center

    Davletbaeva, Diana N.; Pankratova, Elena S.; Minjar-Belorucheva, Alla P.; Bashkirova, Karina A.

    2016-01-01

    Relevance of the problem stated in the article is determined by a poor development of the effective PU teaching methods allowing their quick and profound mastering. Besides, a small attention is given to a place of individual reading lessons as the tools of PU teaching. The article aims to present a general review of the use of foreign literature…

  12. GReAT (General Relativity Accuracy Test): a free fall test of Weak Equivalence Principle from stratospheric balloon altitude .

    NASA Astrophysics Data System (ADS)

    Iafolla, V.; Fiorenza, E.; Lefevre, C.; Nozzoli, S.; Peron, R.; Persichini, M.; Reale, A.; Santoli, F.; Lorenzini, E. C.; Shapiro, I. I.; Ashenberg, J.; Bombardelli, C.; Glashow, S.

    GReAT (General Relativity Accuracy Test) is a free fall experiment from stratospheric balloon altitude to test the Weak Equivalence Principle (WEP) with an accuracy of (5 \\cdot 10^{-15}). The key components of the experiments are a very high accuracy (sensitivity close to (10^{-14}) g/(\\sqrt{Hz}) in a 25-s integration time) differential acceleration detector to detect a possible violation of the WEP and the facility necessary to perform the experiment. The detector will be released to free fall inside an evacuated capsule (Einstein elevator) which has been previously dropped from a stratospheric balloon, and will be slowly rotated about a horizontal axis to modulate the gravity signal and then released inside the capsule, immediately after the capsule's release from the balloon. In this paper, we report the progress in the development of the differential accelerometer that must be able to test the WEP with the declared accuracy. Following a brief description of the overall experiment, we present experimental results obtained with a differential accelerometer prototype, in particular the ability of the sensor to reject common-mode noise components. Finally, we present a new configuration of the differential accelerometer which is less sensitive to higher-order mass moments generated by nearby masses.

  13. Qualitative uncertainty principles for the generalized Fourier transform associated to a Dunkl type operator on the real line

    NASA Astrophysics Data System (ADS)

    Mejjaoli, Hatem; Trimèche, Khalifa

    2016-06-01

    In this paper, we prove various mathematical aspects of the qualitative uncertainty principle, including Hardy's, Cowling-Price's theorem, Morgan's theorem, Beurling, Gelfand-Shilov, Miyachi theorems.

  14. Equivalence principles and electromagnetism

    NASA Technical Reports Server (NTRS)

    Ni, W.-T.

    1977-01-01

    The implications of the weak equivalence principles are investigated in detail for electromagnetic systems in a general framework. In particular, it is shown that the universality of free-fall trajectories (Galileo weak equivalence principle) does not imply the validity of the Einstein equivalence principle. However, the Galileo principle plus the universality of free-fall rotation states does imply the Einstein principle.

  15. Transmembrane Communication: General Principles and Lessons from the Structure and Function of the M2 Proton Channel, K+ Channels, and Integrin Receptors

    PubMed Central

    Grigoryan, Gevorg; Moore, David T.; DeGrado, William F.

    2013-01-01

    Signal transduction across biological membranes is central to life. This process generally happens through communication between different domains and hierarchical coupling of information. Here, we review structural and thermodynamic principles behind transmembrane (TM) signal transduction and discuss common themes. Communication between signaling domains can be understood in terms of thermodynamic and kinetic principles, and complex signaling patterns can arise from simple wiring of thermodynamically coupled domains. We relate this to functions of several signal transduction systems: the M2 proton channel from influenza A virus, potassium channels, integrin receptors, and bacterial kinases. We also discuss key features in the structural rearrangements responsible for signal transduction in these systems. PMID:21548783

  16. Transmembrane communication: general principles and lessons from the structure and function of the M2 proton channel, K⁺ channels, and integrin receptors.

    PubMed

    Grigoryan, Gevorg; Moore, David T; DeGrado, William F

    2011-01-01

    Signal transduction across biological membranes is central to life. This process generally happens through communication between different domains and hierarchical coupling of information. Here, we review structural and thermodynamic principles behind transmembrane (TM) signal transduction and discuss common themes. Communication between signaling domains can be understood in terms of thermodynamic and kinetic principles, and complex signaling patterns can arise from simple wiring of thermodynamically coupled domains. We relate this to functions of several signal transduction systems: the M2 proton channel from influenza A virus, potassium channels, integrin receptors, and bacterial kinases. We also discuss key features in the structural rearrangements responsible for signal transduction in these systems.

  17. Application of HACCP principles to control visitor health threats on dairy farms open to the general public.

    PubMed

    Barten, M; Noordhuizen, J P M; Lipman, L J A

    2008-10-01

    An increasing number of Dutch dairy farmers have diversified their activities, often opening their farm up to visitors (tourist accommodation, farm shop, contact with livestock, etc). It is essential to prevent these visitors from having accidents or becoming ill, which could result in financial claims and might harm the reputation of the agricultural sector. This article describes how the hazard analysis critical control points concept and principles (HACCP) can be applied to these activities and integrated with on-farm operational herd health and production management programmes.

  18. An extremum principle for computation of the zone of tooth contact and generalized transmission error of spiral bevel gears

    NASA Technical Reports Server (NTRS)

    Mark, W. D.

    1988-01-01

    For a given set of forces transmitted by the gears, each of the three components of the generalized transmission error of spiral bevel gears is shown to be stationary with respect to small independent variations in the positions of the endpoints of the lines of tooth contact about their true values. The tangential generalized transmission error component is shown to take on a minimum value at the true endpoint positions. A computational procedure based on the method of steepest descent is described for computing the true line of contact endpoint positions and the three components of the generalized transmission error. A method for computing the Fourier series coefficients of the tooth meshing harmonics of the three generalized transmission error components also is provided.

  19. First principles approach to the Abraham-Minkowski controversy for the momentum of light in general linear non-dispersive media

    NASA Astrophysics Data System (ADS)

    Ramos, Tomás; Rubilar, Guillermo F.; Obukhov, Yuri N.

    2015-02-01

    We study the problem of the definition of the energy-momentum tensor of light in general moving non-dispersive media with linear constitutive law. Using the basic principles of classical field theory, we show that for the correct understanding of the problem, one needs to carefully distinguish situations when the material medium is modeled either as a background on which light propagates or as a dynamical part of the total system. In the former case, we prove that the (generalized) Belinfante-Rosenfeld (BR) tensor for the electromagnetic field coincides with the Minkowski tensor. We derive a complete set of balance equations for this open system and show that the symmetries of the background medium are directly related to the conservation of the Minkowski quantities. In particular, for isotropic media, the angular momentum of light is conserved despite of the fact that the Minkowski tensor is non-symmetric. For the closed system of light interacting with matter, we model the material medium as a relativistic non-dissipative fluid and we prove that it is always possible to express the total BR tensor of the closed system either in the Abraham or in the Minkowski separation. However, in the case of dynamical media, the balance equations have a particularly convenient form in terms of the Abraham tensor. Our results generalize previous attempts and provide a first principles basis for a unified understanding of the long-standing Abraham-Minkowski controversy without ad hoc arguments.

  20. 26 CFR 1.336-1 - General principles, nomenclature, and definitions for a section 336(e) election.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... combination thereof, five percent or more, by value, of the stock of target in the qualified stock disposition... of another corporation. Seller includes both a transferor and a distributor of target stock. Generally, all members of a consolidated group that dispose of target stock are treated as a single...

  1. The discovery of the principles of reinforcement, extinction, generalization, and differentiation of conditional reflexes in Pavlov's laboratories.

    PubMed

    Windholz, G

    1989-01-01

    The discovery of reinforcement, extinction, generalization, and differentiation with the conditional reflex method in Pavlov's laboratories is described. Modern American introductory texts show that contemporary understanding of the experimental work on conditioning in Pavlov's laboratories is derived from a 1927 English translation of Pavlov's lectures on the conditional reflexes. The lectures present the discoveries topically, not chronologically. In contrast, this article presents a chronological account of the contributions of S.G. Vul'fson, I.F. Tolochinov, and B.P. Babkin, which led to the conceptualization of reinforcement and extinction, and the work of V.N. Boldyrev and N.A. Kashereninova, which led to the formulation of the concepts of generalization and differentiation. This historical approach avoids giving the impression that the development of the Pavlovian paradigm was a highly systematic pursuit.

  2. An Application of Educational Theories and Principles of Teaching and Learning Communication Skills for General Practitioners in Oman

    PubMed Central

    Al-Wahaibi, Ahmed; Almahrezi, Abdulaziz

    2009-01-01

    This article discusses the crucial role of teaching and learning communication skills for general practitioners, based on the theory of experiential and self-directed learning. It also outlines the proposed ways and methods to teach these communication skills in this project. The patient-doctor interview or what is known as office visit in some countries and consultation in others is the cornerstone of the entire General Practice (GP) or Family Medicine. It is from this process and outcome that the reputation is gained or destroyed. The analysis of the consultation is complicated and varied but is most usefully employed to assess effecacy in terms of achieving the means that are mutually desired by patients and their carers. PMID:22334856

  3. The hypothesis of neuronal interconnectivity as a function of brain size—a general organization principle of the human connectome

    PubMed Central

    Hänggi, Jürgen; Fövenyi, Laszlo; Liem, Franziskus; Meyer, Martin; Jäncke, Lutz

    2014-01-01

    Twenty years ago, Ringo and colleagues proposed that maintaining absolute connectivity in larger compared with smaller brains is computationally inefficient due to increased conduction delays in transcallosal information transfer and expensive with respect to the brain mass needed to establish these additional connections. Therefore, they postulated that larger brains are relatively stronger connected intrahemispherically and smaller brains interhemispherically, resulting in stronger functional lateralization in larger brains. We investigated neuronal interconnections in 138 large and small human brains using diffusion tensor imaging-based fiber tractography. We found a significant interaction between brain size and the type of connectivity. Structural intrahemispheric connectivity is stronger in larger brains, whereas interhemispheric connectivity is only marginally increased in larger compared with smaller brains. Although brain size and gender are confounded, this effect is gender-independent. Additionally, the ratio of interhemispheric to intrahemispheric connectivity correlates inversely with brain size. The hypothesis of neuronal interconnectivity as a function of brain size might account for shorter and more symmetrical interhemispheric transfer times in women and for empirical evidence that visual and auditory processing are stronger lateralized in men. The hypothesis additionally shows that differences in interhemispheric and intrahemispheric connectivity are driven by brain size and not by gender, a finding contradicting a recently published study. Our findings are also compatible with the idea that the more asymmetric a region is, the smaller the density of interhemispheric connections, but the larger the density of intrahemispheric connections. The hypothesis represents an organization principle of the human connectome that might be applied also to non-human animals as suggested by our cross-species comparison. PMID:25426059

  4. Physical principles of hearing

    NASA Astrophysics Data System (ADS)

    Martin, Pascal

    2015-10-01

    The following sections are included: * Psychophysical properties of hearing * The cochlear amplifier * Mechanosensory hair cells * The "critical" oscillator as a general principle of auditory detection * Bibliography

  5. First-principles calculation of defect free energies: General aspects illustrated in the case of bcc Fe

    NASA Astrophysics Data System (ADS)

    Murali, D.; Posselt, M.; Schiwarth, M.

    2015-08-01

    Modeling of nanostructure evolution in solids requires comprehensive data on the properties of defects such as the vacancy and foreign atoms. Since most processes occur at elevated temperatures, not only the energetics of defects in the ground state, but also their temperature-dependent free energies must be known. The first-principles calculation of contributions of phonon and electron excitations to free formation, binding, and migration energies of defects is illustrated in the case of bcc Fe. First of all, the ground-state properties of the vacancy, the foreign atoms Cu, Y, Ti, Cr, Mn, Ni, V, Mo, Si, Al, Co, O, and the O-vacancy pair are determined under constant volume (CV) as well as zero-pressure (ZP) conditions, and relations between the results of both kinds of calculations are discussed. Second, the phonon contribution to defect free energies is calculated within the harmonic approximation using the equilibrium atomic positions determined in the ground state under CV and ZP conditions. In most cases, the ZP-based free formation energy decreases monotonously with temperature, whereas for CV-based data both an increase and a decrease were found. The application of a quasiharmonic correction to the ZP-based data does not modify this picture significantly. However, the corrected data are valid under zero-pressure conditions at higher temperatures than in the framework of the purely harmonic approach. The difference between CV- and ZP-based data is mainly due to the volume change of the supercell since the relative arrangement of atoms in the environment of the defects is nearly identical in the two cases. A simple transformation similar to the quasiharmonic approach is found between the CV- and ZP-based frequencies. Therefore, it is not necessary to calculate these quantities and the corresponding defect free energies separately. In contrast to ground-state energetics, the CV- and ZP-based defect free energies do not become equal with increasing supercell

  6. General principles for the formation and proliferation of a wall-free (L-form) state in bacteria

    PubMed Central

    Mercier, Romain; Kawai, Yoshikazu; Errington, Jeff

    2014-01-01

    The peptidoglycan cell wall is a defining structural feature of the bacterial kingdom. Curiously, some bacteria have the ability to switch to a wall-free or ‘L-form’ state. Although known for decades, the general properties of L-forms are poorly understood, largely due to the lack of systematic analysis of L-forms in the molecular biology era. Here we show that inhibition of peptidoglycan precursor synthesis promotes the generation of L-forms from both Gram-positive and Gram-negative bacteria. We show that the L-forms generated have in common a mechanism of proliferation involving membrane blebbing and tubulation, which is dependent on an altered rate of membrane synthesis. Crucially, this mode of proliferation is independent of the essential FtsZ based division machinery. Our results suggest that the L-form mode of proliferation is conserved across the bacterial kingdom, reinforcing the idea that it could have been used in primitive cells, and opening up its use in the generation of synthetic cells. DOI: http://dx.doi.org/10.7554/eLife.04629.001 PMID:25358088

  7. Designing and Interpreting Limiting Dilution Assays: General Principles and Applications to the Latent Reservoir for Human Immunodeficiency Virus-1.

    PubMed

    Rosenbloom, Daniel I S; Elliott, Oliver; Hill, Alison L; Henrich, Timothy J; Siliciano, Janet M; Siliciano, Robert F

    2015-12-01

    Limiting dilution assays are widely used in infectious disease research. These assays are crucial for current human immunodeficiency virus (HIV)-1 cure research in particular. In this study, we offer new tools to help investigators design and analyze dilution assays based on their specific research needs. Limiting dilution assays are commonly used to measure the extent of infection, and in the context of HIV they represent an essential tool for studying latency and potential curative strategies. Yet standard assay designs may not discern whether an intervention reduces an already miniscule latent infection. This review addresses challenges arising in this setting and in the general use of dilution assays. We illustrate the major statistical method for estimating frequency of infectious units from assay results, and we offer an online tool for computing this estimate. We recommend a procedure for customizing assay design to achieve desired sensitivity and precision goals, subject to experimental constraints. We consider experiments in which no viral outgrowth is observed and explain how using alternatives to viral outgrowth may make measurement of HIV latency more efficient. Finally, we discuss how biological complications, such as probabilistic growth of small infections, alter interpretations of experimental results.

  8. Averting a Disaster with Groundwater Depletion in India: The General Case of Water Management Principles and Development (Invited)

    NASA Astrophysics Data System (ADS)

    Lall, U.

    2013-12-01

    Many countries, including the USA, China, and India are experiencing chronic groundwater depletion. In part this unsustainable water use results from climatic factors that reduce surface water availability and also the recharge to the aquifer system. However, a more critical factor is uncontrolled use for agriculture and energy and mineral processing. Interestingly in places such as India endowments have been politically created that lead to ever increasing use, through the provision of free energy for pumping. Reversing the situation is considered politically challenging, and the concept of metering and payment for what is essentially economic use of water is also considered difficult to apply. In this talk I use the Indian situation as a general example and discuss the role central planning strategies for demand and resource management can play recognizing the private action by millions of users as an inevitable tool that needs to be leveraged without necessarily the high transaction costs that come with monitoring and fee collection for monitored use. Specifically, targeting and stimulating potential cropping strategies and on farm water and energy management emerge as a choice in a difficult management environment. In a broader development context, I argue that the role of private sector aggregators in developing farm to market procurement strategies can play a role in both improving rural economies and providing a trajectory for more efficient water use through technology and crop choice.

  9. Three-year-olds obey the sample size principle of induction: the influence of evidence presentation and sample size disparity on young children's generalizations.

    PubMed

    Lawson, Chris A

    2014-07-01

    Three experiments with 81 3-year-olds (M=3.62years) examined the conditions that enable young children to use the sample size principle (SSP) of induction-the inductive rule that facilitates generalizations from large rather than small samples of evidence. In Experiment 1, children exhibited the SSP when exemplars were presented sequentially but not when exemplars were presented simultaneously. Results from Experiment 3 suggest that the advantage of sequential presentation is not due to the additional time to process the available input from the two samples but instead may be linked to better memory for specific individuals in the large sample. In addition, findings from Experiments 1 and 2 suggest that adherence to the SSP is mediated by the disparity between presented samples. Overall, these results reveal that the SSP appears early in development and is guided by basic cognitive processes triggered during the acquisition of input.

  10. General Principles for Brain Design

    NASA Astrophysics Data System (ADS)

    Josephson, Brian D.

    2006-06-01

    The task of understanding how the brain works has met with only limited success since important design concepts are not as yet incorporated in the analysis. Relevant concepts can be uncovered by studying the powerful methodologies that have evolved in the context of computer programming, raising the question of how the concepts involved there can be realised in neural hardware. Insights can be gained in regard to such issues through the study of the role played by models and representation. These insights lead on to an appreciation of the mechanisms underlying subtle capacities such as those concerned with the use of language. A precise, essentially mathematical account of such capacities is in prospect for the future.

  11. Disruption of long-range gene regulation in human genetic disease: a kaleidoscope of general principles, diverse mechanisms and unique phenotypic consequences.

    PubMed

    Bhatia, Shipra; Kleinjan, Dirk A

    2014-07-01

    The precise control of gene expression programs is crucial for the establishment of the diverse gene activity patterns required for the correct development, patterning and differentiation of the myriad of cell types within an organism. The crucial importance of non-coding regions of the genome in the control of gene regulation is well established and depends on a diverse group of sequence fragments called cis-regulatory elements that reside in these regions. Advances in novel genome-wide techniques have greatly increased the ability to identify potential regulatory elements. In contrast, their functional characterisation and the determination of their diverse modes of action remain a major bottleneck. Greater knowledge of gene expression control is of major importance for human health as disruption of gene regulation has become recognised as a significant cause of human disease. Appreciation of the role of cis-regulatory polymorphism in natural variation and susceptibility to common disease is also growing. While novel techniques such as GWAS and NGS provide the ability to collect large genomic datasets, the challenge for the twenty-first century will be to extract the relevant sequences and how to investigate the functional consequences of disease-associated changes. Here, we review how studies of transcriptional control at selected paradigm disease gene loci have revealed general principles of cis-regulatory logic and regulatory genome organisation, yet also demonstrate how the variety of mechanisms can combine to result in unique phenotypic outcomes. Integration of these principles with the emerging wealth of genome-wide data will provide enhanced insight into the workings of our regulatory genome.

  12. Bernoulli's Principle

    ERIC Educational Resources Information Center

    Hewitt, Paul G.

    2004-01-01

    Some teachers have difficulty understanding Bernoulli's principle particularly when the principle is applied to the aerodynamic lift. Some teachers favor using Newton's laws instead of Bernoulli's principle to explain the physics behind lift. Some also consider Bernoulli's principle too difficult to explain to students and avoid teaching it…

  13. Earth's Earliest Ecosystems in the C: The Use of Microbial Mats to Demonstrate General Principles of Scientific Inquiry and Microbial Ecology

    NASA Technical Reports Server (NTRS)

    Bebout, Brad M.; Bucaria, Robin

    2006-01-01

    Microbial mats are living examples of the most ancient biological communities on Earth. As Earth's earliest ecosystems, they are centrally important to understanding the history of life on our planet and are useful models for the search for life elsewhere. As relatively compact (but complete) ecosystems, microbial mats are also extremely useful for educational activities. Mats may be used to demonstrate a wide variety of concepts in general and microbial ecology, including the biogeochemical cycling of elements, photosynthesis and respiration, and the origin of the Earth's present oxygen containing atmosphere. Microbial mats can be found in a number of common environments accessible to teachers, and laboratory microbial mats can be constructed using materials purchased from biological supply houses. With funding from NASA's Exobiology program, we have developed curriculum and web-based activities centered on the use of microbial mats as tools for demonstrating general principles in ecology, and the scientific process. Our web site (http://microbes.arc.nasa.gov) includes reference materials, lesson plans, and a "Web Lab", featuring living mats maintained in a mini-aquarium. The site also provides information as to how research on microbial mats supports NASA's goals, and various NASA missions. A photo gallery contains images of mats, microscopic views of the organisms that form them, and our own research activities. An animated educational video on the web site uses computer graphic and video microscopy to take students on a journey into a microbial mat. These activities are targeted to a middle school audience and are aligned with the National Science Standards.

  14. Principles of learning.

    PubMed

    Voith, V L

    1986-12-01

    This article discusses some general principles of learning as well as possible constraints and how such principles can apply to horses. A brief review is presented of experiments that were designed to assess learning in horses. The use of behavior modification techniques to treat behavior problems in horses is discussed and several examples of the use of these techniques are provided. PMID:3492241

  15. Earth's Earliest Ecosystems in the Classroom: The Use of Microbial Mats to Illustrate and Demonstrate General Principles of Scientific Inquiry and Microbial Ecology

    NASA Astrophysics Data System (ADS)

    Bebout, B. M.; Bucaria, R.

    2004-12-01

    Microbial mats are living examples of the most ancient biological communities on Earth. As Earth's earliest ecosystems, they are centrally important to understanding the history of life on our planet and are useful models for the search for life elsewhere. As relatively small (but complete) ecosystems, microbial mats are also extremely useful for educational activities. Mats may be used to demonstrate a wide variety of concepts in general and microbial ecology, including the biogeochemical cycling of elements, photosynthesis and respiration, and the and the origin of the Earth's present oxygen containing atmosphere. Microbial mats can be found in a number of common environments accessible to teachers, and laboratory microbial mats can even be constructed using materials purchased from biological supply houses. With funding from NASA's Exobiology program, provided as a supplement to our research funding, we are developing curriculum and web-based activities centered on the use of microbial mats as tools for demonstrating general principles in ecology, and the scientific process. A web site with useful background information and links is now on-line. The curriculum, now in the pilot phase, is an integrated module having Science, Math and Language Art threads. A "Web Lab", featuring living mats maintained in a mini-aquarium, and complete with remotely-operable instrumentation not commonly available in classrooms, will be available to classrooms over the Internet. Using that system, the responses of the mat community to changes in environmental parameters, (e.g., light, pH, flow, and temperature) can be monitored using microsensors. Students will be able to develop hypotheses and propose experiments in the Web Lab to test them. Data from these experiments will be posted in real time and students will be able to collect the data, analyze it, and post results and conclusions back to the web page in a true implementation of the scientific inquiry process. The web site

  16. Principled Narrative

    ERIC Educational Resources Information Center

    MacBeath, John; Swaffield, Sue; Frost, David

    2009-01-01

    This article provides an overview of the "Carpe Vitam: Leadership for Learning" project, accounting for its provenance and purposes, before focusing on the principles for practice that constitute an important part of the project's legacy. These principles framed the dialogic process that was a dominant feature of the project and are presented,…

  17. Buridan's Principle

    NASA Astrophysics Data System (ADS)

    Lamport, Leslie

    2012-08-01

    Buridan's principle asserts that a discrete decision based upon input having a continuous range of values cannot be made within a bounded length of time. It appears to be a fundamental law of nature. Engineers aware of it can design devices so they have an infinitessimal probability of not making a decision quickly enough. Ignorance of the principle could have serious consequences.

  18. Principles of Tendon Transfer.

    PubMed

    Wilbur, Danielle; Hammert, Warren C

    2016-08-01

    Tendon transfers provide a substitute, either temporary or permanent, when function is lost due to neurologic injury in stroke, cerebral palsy or central nervous system lesions, peripheral nerve injuries, or injuries to the musculotendinous unit itself. This article reviews the basic principles of tendon transfer, which are important when planning surgery and essential for an optimal outcome. In addition, concepts for coapting the tendons during surgery and general principles to be followed during the rehabilitation process are discussed. PMID:27387072

  19. Developments of the general relativity accuracy test (GReAT): a ground-based experiment to test the weak equivalence principle

    NASA Astrophysics Data System (ADS)

    Iafolla, V.; Nozzoli, S.; Lorenzini, E. C.; Shapiro, I. I.; Milyukov, V.

    2000-06-01

    Some future tests of the weak equivalence principle (WEP) with laboratory-size proof masses are likely to be conducted in freefall conditions in order to improve the test accuracy substantially. Some years ago the authors of this paper proposed to test the WEP in a vertical freefall inside a capsule released from a high-altitude balloon. The estimated accuracy in testing the WEP, with a 95% confidence level, is a few parts in 1015 in a 30 s freefall. When compared with other proposed orbital freefall experiments and ground-based tests, the vertical freefall retains some key advantages of the former without some of the disadvantages of the latter. Moreover, a two orders of magnitude increase in the accuracy of testing the WEP could be achieved with an affordable experiment that allows us to recover the detector and repeat the launches at short time intervals.

  20. Earth's Earliest Ecosystems in the Classroom: The Use of Microbial Mats to Teach General Principles in Microbial Ecology, and Scientific Inquiry

    NASA Technical Reports Server (NTRS)

    Beboutl, Brad M.; Bucaria, Robin

    2004-01-01

    Microbial mats are living examples of the most ancient biological communities on earth, and may also be useful models for the search for life elsewhere. They are centrally important to Astrobiology. In this lecture, we will present an introduction to microbial mats, as well as an introduction to our web-based educational module on the subject of microbial ecology, featuring living mats maintained in a mini "Web Lab" complete with remotely-operable instrumentation. We have partnered with a number of outreach specialists in order to produce an informative and educational web-based presentation, aspects of which will be exported to museum exhibits reaching a wide audience. On our web site, we will conduct regularly scheduled experimental manipulations, linking the experiments to our research activities, and demonstrating fundamental principles of scientific research.

  1. Variational principles of irreversible processes

    NASA Astrophysics Data System (ADS)

    Ichiyanagi, Masakazu

    1994-07-01

    This article reviews developments of variational principles in the study of irreversible processes during the past three decades or so. The variational principles we consider here are related to entropy production. The purpose of this article is to explicate that we can formulate a variational principle which relates the transport coefficients to microscopic dynamics of fluctuations. The quantum variational principle restricts the nonequilibrium density matrix to a class conforming to the requirement demanded by the second law of thermodynamics. These are various kinds of variational principles according to different stages of a macroscopic system. The three stages are known, which are dynamical, kinetic, and thermodynamical stages. The relationships among these variational principles are discussed from the point of view of the contraction of information about irrelevant components. Nakano's variational principle has close similarity to the Lippmann-Schwinger theory of scattering, in which some incoming and outgoing disturbances have to be considered in a pair. It is also shown that the variational principle of Onsager's type can be reformulated in the form of Hamilton's principle if a generalization of Hamilton's principle proposed by Djukic and Vujanovic is used. A variational principle in the diagrammatic method is also reviewed, which utilizes the generalized Ward-Takahashi relations.

  2. Fermat's Principle Revisited.

    ERIC Educational Resources Information Center

    Kamat, R. V.

    1991-01-01

    A principle is presented to show that, if the time of passage of light is expressible as a function of discrete variables, one may dispense with the more general method of the calculus of variations. The calculus of variations and the alternative are described. The phenomenon of mirage is discussed. (Author/KR)

  3. 48 CFR 49.113 - Cost principles.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Cost principles. 49.113... TERMINATION OF CONTRACTS General Principles 49.113 Cost principles. The cost principles and procedures in the..., negotiating, or determining costs relevant to termination settlements under contracts with other...

  4. Genetic principles.

    PubMed

    Abuelo, D

    1987-01-01

    The author discusses the basic principles of genetics, including the classification of genetic disorders and a consideration of the rules and mechanisms of inheritance. The most common pitfalls in clinical genetic diagnosis are described, with emphasis on the problem of the negative or misleading family history.

  5. Yielding Unexpected Results: Precipitation of Ba[subscript3](PO[subscript4])[subscript2] and Implications for Teaching Solubility Principles in the General Chemistry Curriculum

    ERIC Educational Resources Information Center

    Hazen, Jeffery L.; Cleary, David A.

    2014-01-01

    Precipitation of barium phosphate from aqueous solutions of a barium salt and a phosphate salt forms the basis for a number of conclusions drawn in general chemistry. For example, the formation of a solid white precipitate is offered as evidence that barium phosphate is insoluble. Furthermore, analysis of the supernatant is used to illustrate the…

  6. A multifunction network of computers in a large pathology department. Integration of word processing, data base management, and general purpose computing using network principles.

    PubMed

    Cechner, R L

    1983-04-01

    We report the strategies for design and implementation of a system of compatible mini- and microcomputers intended to improve efficiency of data handling and research in several clinical and academic divisions of a large university hospital department of Pathology. A dedicated, preprogrammed, multiuser, word processing computer and small standalone word processing stations connected to a general purpose minicomputer, using standard network protocols for communication, permit virtually error-free movement of data between computers doing functionally distinct tasks of word processing, data base management, and general scientific computing. User programming is minimized and is done in a simple, well-known, high-level language. We show that cost, thruput, speed, document volume, document size, revision cycle frequency, data base size, and frequency of use are important design criteria and that existing staff can be trained easily to operate the systems.

  7. Radar principles

    NASA Technical Reports Server (NTRS)

    Sato, Toru

    1989-01-01

    Discussed here is a kind of radar called atmospheric radar, which has as its target clear air echoes from the earth's atmosphere produced by fluctuations of the atmospheric index of refraction. Topics reviewed include the vertical structure of the atmosphere, the radio refractive index and its fluctuations, the radar equation (a relation between transmitted and received power), radar equations for distributed targets and spectral echoes, near field correction, pulsed waveforms, the Doppler principle, and velocity field measurements.

  8. American Evaluation Association Guiding Principles for Evaluators

    SciTech Connect

    2009-01-18

    Five principles developed by American Evaluation Associ intended to guide professional practice of evaluators & to inform evaluation clients and the general public about principles they can expect to be upheld by professional evaluators.

  9. Direct Linearization and Adjoint Approaches to Evaluation of Atmospheric Weighting Functions and Surface Partial Derivatives: General Principles, Synergy and Areas of Application

    NASA Technical Reports Server (NTRS)

    Ustino, Eugene A.

    2006-01-01

    This slide presentation reviews the observable radiances as functions of atmospheric parameters and of surface parameters; the mathematics of atmospheric weighting functions (WFs) and surface partial derivatives (PDs) are presented; and the equation of the forward radiative transfer (RT) problem is presented. For non-scattering atmospheres this can be done analytically, and all WFs and PDs can be computed analytically using the direct linearization approach. For scattering atmospheres, in general case, the solution of the forward RT problem can be obtained only numerically, but we need only two numerical solutions: one of the forward RT problem and one of the adjoint RT problem to compute all WFs and PDs we can think of. In this presentation we discuss applications of both the linearization and adjoint approaches

  10. Computational principles of memory.

    PubMed

    Chaudhuri, Rishidev; Fiete, Ila

    2016-03-01

    The ability to store and later use information is essential for a variety of adaptive behaviors, including integration, learning, generalization, prediction and inference. In this Review, we survey theoretical principles that can allow the brain to construct persistent states for memory. We identify requirements that a memory system must satisfy and analyze existing models and hypothesized biological substrates in light of these requirements. We also highlight open questions, theoretical puzzles and problems shared with computer science and information theory. PMID:26906506

  11. Gamma-Ray Telescope and Uncertainty Principle

    ERIC Educational Resources Information Center

    Shivalingaswamy, T.; Kagali, B. A.

    2012-01-01

    Heisenberg's Uncertainty Principle is one of the important basic principles of quantum mechanics. In most of the books on quantum mechanics, this uncertainty principle is generally illustrated with the help of a gamma ray microscope, wherein neither the image formation criterion nor the lens properties are taken into account. Thus a better…

  12. Abolishing the maximum tension principle

    NASA Astrophysics Data System (ADS)

    Dąbrowski, Mariusz P.; Gohar, H.

    2015-09-01

    We find the series of example theories for which the relativistic limit of maximum tension Fmax =c4 / 4 G represented by the entropic force can be abolished. Among them the varying constants theories, some generalized entropy models applied both for cosmological and black hole horizons as well as some generalized uncertainty principle models.

  13. Precautionary principle in international law.

    PubMed

    Saladin, C

    2000-01-01

    The deregulatory nature of trade rules frequently brings them into conflict with the precautionary principle. These rules dominate debate over the content and legal status of the precautionary principle at the international level. The World Trade Organization (WTO), because of its power in settling disputes, is a key player. Many States are concerned to define the precautionary principle consistent with WTO rules, which generally means defining it as simply a component of risk analysis. At the same time, many States, especially environmental and public health policymakers, see the principle as the legal basis for preserving domestic and public health measures in the face of deregulatory pressures from the WTO. The precautionary principle has begun to acquire greater content and to move into the operative articles of legally binding international agreements. It is important to continue this trend.

  14. Tetralogy of Fallot: General Principles of Management.

    PubMed

    Downing, Tacy E; Kim, Yuli Y

    2015-11-01

    Repaired tetralogy of Fallot (TOF) is one of the most common diagnoses encountered when caring for adults with congenital heart disease. Although long-term survival after childhood TOF repair is excellent, morbidity is common and most patients require reintervention in adulthood. This review provides an overview of key surveillance and management issues for adults with TOF, including residual right ventricular outflow tract disease and timing of pulmonary valve replacement, arrhythmias and risk stratification, left-sided heart disease and heart failure, and pregnancy management.

  15. 39 CFR 268.1 - General principles.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... agencies, including the Postal Service, and their employees. In implementation of these requirements, the... Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION PRIVACY OF INFORMATION-EMPLOYEE RULES... need to collect various types of personally identifiable information about its customers, employees...

  16. 16 CFR 260.3 - General principles.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... our previous bathroom tiles.” Example 2: An advertiser claims that “our plastic diaper liner has the most recycled content.” The diaper liner has more recycled content, calculated as a percentage...

  17. 16 CFR 260.3 - General principles.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... our previous bathroom tiles.” Example 2: An advertiser claims that “our plastic diaper liner has the most recycled content.” The diaper liner has more recycled content, calculated as a percentage...

  18. Chemoprevention--history and general principles.

    PubMed

    Wu, Xiangwei; Patterson, Sherri; Hawk, Ernest

    2011-08-01

    Our current understanding of tumourigenesis suggests that cancer develops as a series of cumulative genetic and epigenetic derangements across time culminating in a clone of cells differing from its population of origin in terms of cellular identity, growth control, and its contextual relationship to its environment. Our increasing knowledge of the timing, sequence, frequency, and specific implications of these changes provides unique opportunities for earlier identification of aberrations and preventive interventions. Here we discuss the fundamentals of cancer prevention including the targets, cohorts, agents, endpoints, mechanistic biomarkers, designs, and strategies employed in preventive drug development. There have been many notable successes in this field such as the identification and development of tamoxifen and raloxifene for breast cancer risk reduction, instillational BCG and valrubicin for treatment of preinvasive bladder cancer, and a variety of topical and systemic agents that effectively treat preinvasive neoplastic lesions of the skin. A variety of null or negative developmental endeavours have occurred as well, including trials of beta-carotene for lung cancer prevention, nutritional modifications for colorectal adenoma prevention, and most recently, selenium and alpha-tocopherol for prostate cancer prevention. A third category of prevention trials can be summarized as investigationally successful, but not achieving regulatory success. The development of finasteride and dutasteride for prostate cancer prevention, and celecoxib for colorectal neoplasia prevention fall into this category. In less than four decades, cancer chemoprevention has transformed from a concept to an achievable reality. PMID:22122762

  19. 18 CFR 358.2 - General principles.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... transmission of electric energy in interstate commerce, or with respect to the wholesale sale of natural gas or of electric energy in interstate commerce. (b) As more fully described and implemented in subsequent....2 Section 358.2 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY...

  20. 18 CFR 358.2 - General principles.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... transmission of electric energy in interstate commerce, or with respect to the wholesale sale of natural gas or of electric energy in interstate commerce. (b) As more fully described and implemented in subsequent....2 Section 358.2 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY...

  1. 20 CFR 401.140 - General principles.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Employees' Benefits SOCIAL SECURITY ADMINISTRATION PRIVACY AND DISCLOSURE OF OFFICIAL RECORDS AND... would result in a “clearly unwarranted invasion of personal privacy.” To decide whether a disclosure would be a clearly unwarranted invasion of personal privacy we consider— (a) The sensitivity of...

  2. 16 CFR 260.6 - General principles.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    .... Example 4: A package of paper coffee filters is labeled “These filters were made with a chlorine-free..., but still significant, amount of the same harmful byproducts associated with chlorine bleaching. The... chlorine bleaching. A claim, however, that the filters were “bleached with a process that...

  3. 21 CFR 502.5 - General principles.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... of such ingredient(s) or component(s) in the food has a material bearing on price or consumer acceptance or when the labeling or the appearance of the food may otherwise create an erroneous impression... or absence of such ingredient(s) or component(s) in the food has a material bearing on price...

  4. 21 CFR 102.5 - General principles.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... bearing on price or consumer acceptance or when the labeling or the appearance of the food may otherwise... of such ingredient(s) or component(s) in the food has a material bearing on price or consumer acceptance or when the labeling or the appearance of the food may otherwise create an erroneous...

  5. 21 CFR 102.5 - General principles.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... bearing on price or consumer acceptance or when the labeling or the appearance of the food may otherwise... of such ingredient(s) or component(s) in the food has a material bearing on price or consumer acceptance or when the labeling or the appearance of the food may otherwise create an erroneous...

  6. 21 CFR 102.5 - General principles.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... bearing on price or consumer acceptance or when the labeling or the appearance of the food may otherwise... of such ingredient(s) or component(s) in the food has a material bearing on price or consumer acceptance or when the labeling or the appearance of the food may otherwise create an erroneous...

  7. 21 CFR 502.5 - General principles.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... of such ingredient(s) or component(s) in the food has a material bearing on price or consumer acceptance or when the labeling or the appearance of the food may otherwise create an erroneous impression... or absence of such ingredient(s) or component(s) in the food has a material bearing on price...

  8. 16 CFR 260.6 - General principles.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... bleaching process.” The filters are bleached with a process that releases into the environment a reduced, but still significant, amount of the same harmful byproducts associated with chlorine bleaching. The... chlorine bleaching. A claim, however, that the filters were “bleached with a process that...

  9. 16 CFR 260.6 - General principles.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... bleaching process.” The filters are bleached with a process that releases into the environment a reduced, but still significant, amount of the same harmful byproducts associated with chlorine bleaching. The... chlorine bleaching. A claim, however, that the filters were “bleached with a process that...

  10. Guideline 4: Medication Treatment: General Principles.

    ERIC Educational Resources Information Center

    American Journal on Mental Retardation, 2000

    2000-01-01

    The fourth in seven sets of guidelines based on the consensus of experts in the treatment of psychiatric and behavioral problems in mental retardation (MR) focuses on medication treatment. Guidelines cover strategies of medication management, when to include a medication in the initial treatment plan, and reasons for long-term medication…

  11. General Principles of Organisation of Production.

    ERIC Educational Resources Information Center

    Yazvina, A.

    Briefly described with accompanying photographs are development of employment opportunities for the blind and the current status of production by the blind in the Union of Soviet Socialist Republics. It is explained that with the founding of the All-Russia Society for the Blind in 1925, efforts were made to train the blind in workshops. The return…

  12. 21 CFR 502.5 - General principles.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS... of such ingredient(s) or component(s) in the food has a material bearing on price or consumer... or absence of such ingredient(s) or component(s) in the food has a material bearing on price...

  13. Common Principles and Multiculturalism

    PubMed Central

    Zahedi, Farzaneh; Larijani, Bagher

    2009-01-01

    Judgment on rightness and wrongness of beliefs and behaviors is a main issue in bioethics. Over centuries, big philosophers and ethicists have been discussing the suitable tools to determine which act is morally sound and which one is not. Emerging the contemporary bioethics in the West has resulted in a misconception that absolute westernized principles would be appropriate tools for ethical decision making in different cultures. We will discuss this issue by introducing a clinical case. Considering various cultural beliefs around the world, though it is not logical to consider all of them ethically acceptable, we can gather on some general fundamental principles instead of going to the extremes of relativism and absolutism. Islamic teachings, according to the presented evidence in this paper, fall in with this idea. PMID:23908720

  14. Common principles and multiculturalism.

    PubMed

    Zahedi, Farzaneh; Larijani, Bagher

    2009-01-01

    Judgment on rightness and wrongness of beliefs and behaviors is a main issue in bioethics. Over centuries, big philosophers and ethicists have been discussing the suitable tools to determine which act is morally sound and which one is not. Emerging the contemporary bioethics in the West has resulted in a misconception that absolute westernized principles would be appropriate tools for ethical decision making in different cultures. We will discuss this issue by introducing a clinical case. Considering various cultural beliefs around the world, though it is not logical to consider all of them ethically acceptable, we can gather on some general fundamental principles instead of going to the extremes of relativism and absolutism. Islamic teachings, according to the presented evidence in this paper, fall in with this idea.

  15. Common principles and multiculturalism.

    PubMed

    Zahedi, Farzaneh; Larijani, Bagher

    2009-01-01

    Judgment on rightness and wrongness of beliefs and behaviors is a main issue in bioethics. Over centuries, big philosophers and ethicists have been discussing the suitable tools to determine which act is morally sound and which one is not. Emerging the contemporary bioethics in the West has resulted in a misconception that absolute westernized principles would be appropriate tools for ethical decision making in different cultures. We will discuss this issue by introducing a clinical case. Considering various cultural beliefs around the world, though it is not logical to consider all of them ethically acceptable, we can gather on some general fundamental principles instead of going to the extremes of relativism and absolutism. Islamic teachings, according to the presented evidence in this paper, fall in with this idea. PMID:23908720

  16. Principles of Natural Photosynthesis.

    PubMed

    Krewald, Vera; Retegan, Marius; Pantazis, Dimitrios A

    2016-01-01

    Nature relies on a unique and intricate biochemical setup to achieve sunlight-driven water splitting. Combined experimental and computational efforts have produced significant insights into the structural and functional principles governing the operation of the water-oxidizing enzyme Photosystem II in general, and of the oxygen-evolving manganese-calcium cluster at its active site in particular. Here we review the most important aspects of biological water oxidation, emphasizing current knowledge on the organization of the enzyme, the geometric and electronic structure of the catalyst, and the role of calcium and chloride cofactors. The combination of recent experimental work on the identification of possible substrate sites with computational modeling have considerably limited the possible mechanistic pathways for the critical O-O bond formation step. Taken together, the key features and principles of natural photosynthesis may serve as inspiration for the design, development, and implementation of artificial systems. PMID:26099285

  17. Equivalence Principle and Gravitational Redshift

    SciTech Connect

    Hohensee, Michael A.; Chu, Steven; Mueller, Holger; Peters, Achim

    2011-04-15

    We investigate leading order deviations from general relativity that violate the Einstein equivalence principle in the gravitational standard model extension. We show that redshift experiments based on matter waves and clock comparisons are equivalent to one another. Consideration of torsion balance tests, along with matter-wave, microwave, optical, and Moessbauer clock tests, yields comprehensive limits on spin-independent Einstein equivalence principle-violating standard model extension terms at the 10{sup -6} level.

  18. The average enzyme principle.

    PubMed

    Reznik, Ed; Chaudhary, Osman; Segrè, Daniel

    2013-09-01

    The Michaelis-Menten equation for an irreversible enzymatic reaction depends linearly on the enzyme concentration. Even if the enzyme concentration changes in time, this linearity implies that the amount of substrate depleted during a given time interval depends only on the average enzyme concentration. Here, we use a time re-scaling approach to generalize this result to a broad category of multi-reaction systems, whose constituent enzymes have the same dependence on time, e.g. they belong to the same regulon. This "average enzyme principle" provides a natural methodology for jointly studying metabolism and its regulation.

  19. Principles of Quantum Mechanics

    NASA Astrophysics Data System (ADS)

    Landé, Alfred

    2013-10-01

    Preface; Introduction: 1. Observation and interpretation; 2. Difficulties of the classical theories; 3. The purpose of quantum theory; Part I. Elementary Theory of Observation (Principle of Complementarity): 4. Refraction in inhomogeneous media (force fields); 5. Scattering of charged rays; 6. Refraction and reflection at a plane; 7. Absolute values of momentum and wave length; 8. Double ray of matter diffracting light waves; 9. Double ray of matter diffracting photons; 10. Microscopic observation of ρ (x) and σ (p); 11. Complementarity; 12. Mathematical relation between ρ (x) and σ (p) for free particles; 13. General relation between ρ (q) and σ (p); 14. Crystals; 15. Transition density and transition probability; 16. Resultant values of physical functions; matrix elements; 17. Pulsating density; 18. General relation between ρ (t) and σ (є); 19. Transition density; matrix elements; Part II. The Principle of Uncertainty: 20. Optical observation of density in matter packets; 21. Distribution of momenta in matter packets; 22. Mathematical relation between ρ and σ; 23. Causality; 24. Uncertainty; 25. Uncertainty due to optical observation; 26. Dissipation of matter packets; rays in Wilson Chamber; 27. Density maximum in time; 28. Uncertainty of energy and time; 29. Compton effect; 30. Bothe-Geiger and Compton-Simon experiments; 31. Doppler effect; Raman effect; 32. Elementary bundles of rays; 33. Jeans' number of degrees of freedom; 34. Uncertainty of electromagnetic field components; Part III. The Principle of Interference and Schrödinger's equation: 35. Physical functions; 36. Interference of probabilities for p and q; 37. General interference of probabilities; 38. Differential equations for Ψp (q) and Xq (p); 39. Differential equation for фβ (q); 40. The general probability amplitude Φβ' (Q); 41. Point transformations; 42. General theorem of interference; 43. Conjugate variables; 44. Schrödinger's equation for conservative systems; 45. Schr

  20. "C.R.E.A.T.E."-ing Unique Primary-Source Research Paper Assignments for a Pleasure and Pain Course Teaching Neuroscientific Principles in a Large General Education Undergraduate Course.

    PubMed

    Bodnar, Richard J; Rotella, Francis M; Loiacono, Ilyssa; Coke, Tricia; Olsson, Kerstin; Barrientos, Alicia; Blachorsky, Lauren; Warshaw, Deena; Buras, Agata; Sanchez, Ciara M; Azad, Raihana; Stellar, James R

    2016-01-01

    A large (250 registrants) General Education lecture course, Pleasure and Pain, presented basic neuroscience principles as they related to animal and human models of pleasure and pain by weaving basic findings related to food and drug addiction and analgesic states with human studies examining empathy, social neuroscience and neuroeconomics. In its first four years, the course grade was based on weighted scores from two multiple-choice exams and a five-page review of three unique peer-reviewed research articles. Although well-registered and well-received, 18% of the students received Incomplete grades, primarily due to failing to submit the paper that went largely unresolved and eventually resulted in a failing grade. To rectify this issue, a modified version of the C.R.E.A.T.E. (Consider, Read, Elucidate hypotheses, Analyze and interpret data, Think of the next Experiment) method replaced the paper with eight structured assignments focusing on an initial general-topic article, the introduction-methods, and results-discussion of each of three related peer-review neuroscience-related articles, and a final summary. Compliance in completing these assignments was very high, resulting in only 11 INC grades out of 228 students. Thus, use of the C.R.E.A.T.E. method reduced the percentage of problematic INC grades from 18% to 4.8%, a 73% decline, without changing the overall grade distribution. Other analyses suggested the students achieved a deeper understanding of the scientific process using the C.R.E.A.T.E. method relative to the original term paper assignment. PMID:27385918

  1. "C.R.E.A.T.E."-ing Unique Primary-Source Research Paper Assignments for a Pleasure and Pain Course Teaching Neuroscientific Principles in a Large General Education Undergraduate Course.

    PubMed

    Bodnar, Richard J; Rotella, Francis M; Loiacono, Ilyssa; Coke, Tricia; Olsson, Kerstin; Barrientos, Alicia; Blachorsky, Lauren; Warshaw, Deena; Buras, Agata; Sanchez, Ciara M; Azad, Raihana; Stellar, James R

    2016-01-01

    A large (250 registrants) General Education lecture course, Pleasure and Pain, presented basic neuroscience principles as they related to animal and human models of pleasure and pain by weaving basic findings related to food and drug addiction and analgesic states with human studies examining empathy, social neuroscience and neuroeconomics. In its first four years, the course grade was based on weighted scores from two multiple-choice exams and a five-page review of three unique peer-reviewed research articles. Although well-registered and well-received, 18% of the students received Incomplete grades, primarily due to failing to submit the paper that went largely unresolved and eventually resulted in a failing grade. To rectify this issue, a modified version of the C.R.E.A.T.E. (Consider, Read, Elucidate hypotheses, Analyze and interpret data, Think of the next Experiment) method replaced the paper with eight structured assignments focusing on an initial general-topic article, the introduction-methods, and results-discussion of each of three related peer-review neuroscience-related articles, and a final summary. Compliance in completing these assignments was very high, resulting in only 11 INC grades out of 228 students. Thus, use of the C.R.E.A.T.E. method reduced the percentage of problematic INC grades from 18% to 4.8%, a 73% decline, without changing the overall grade distribution. Other analyses suggested the students achieved a deeper understanding of the scientific process using the C.R.E.A.T.E. method relative to the original term paper assignment.

  2. “C.R.E.A.T.E.”-ing Unique Primary-Source Research Paper Assignments for a Pleasure and Pain Course Teaching Neuroscientific Principles in a Large General Education Undergraduate Course

    PubMed Central

    Bodnar, Richard J.; Rotella, Francis M.; Loiacono, Ilyssa; Coke, Tricia; Olsson, Kerstin; Barrientos, Alicia; Blachorsky, Lauren; Warshaw, Deena; Buras, Agata; Sanchez, Ciara M.; Azad, Raihana; Stellar, James R.

    2016-01-01

    A large (250 registrants) General Education lecture course, Pleasure and Pain, presented basic neuroscience principles as they related to animal and human models of pleasure and pain by weaving basic findings related to food and drug addiction and analgesic states with human studies examining empathy, social neuroscience and neuroeconomics. In its first four years, the course grade was based on weighted scores from two multiple-choice exams and a five-page review of three unique peer-reviewed research articles. Although well-registered and well-received, 18% of the students received Incomplete grades, primarily due to failing to submit the paper that went largely unresolved and eventually resulted in a failing grade. To rectify this issue, a modified version of the C.R.E.A.T.E. (Consider, Read, Elucidate hypotheses, Analyze and interpret data, Think of the next Experiment) method replaced the paper with eight structured assignments focusing on an initial general-topic article, the introduction-methods, and results-discussion of each of three related peer-review neuroscience-related articles, and a final summary. Compliance in completing these assignments was very high, resulting in only 11 INC grades out of 228 students. Thus, use of the C.R.E.A.T.E. method reduced the percentage of problematic INC grades from 18% to 4.8%, a 73% decline, without changing the overall grade distribution. Other analyses suggested the students achieved a deeper understanding of the scientific process using the C.R.E.A.T.E. method relative to the original term paper assignment. PMID:27385918

  3. Information and communication on risks related to medications and proper use of medications for healthcare professionals and the general public: precautionary principle, risk management, communication during and in the absence of crisis situations.

    PubMed

    Molimard, Mathieu; Bernaud, Corine; Lechat, Philippe; Bejan-Angoulvant, Theodora; Benattia, Cherif; Benkritly, Amel; Braunstein, David; Cabut, Sandrine; David, Nadine; Fourrier-Réglat, Annie; Gallet, Benoit; Gersberg, Marta; Goni, Sylvia; Jolliet, Pascale; Lamarque-Garnier, Véronique; Le Jeunne, Claire; Leurs, Irina; Liard, François; Malbezin, Muriel; Micallef, Joelle; Nguon, Marina

    2014-01-01

    Recent drug crises have highlighted the complexity, benefits and risks of medication communication. The difficulty of this communication is due to the diversity of the sources of information and the target audience, the credibility of spokespersons, the difficulty to communicate on scientific uncertainties and the precautionary principle, which is influenced by variable perceptions and tolerances of the risk. Globally, there is a lack of training in risk management with a tendency of modern society to refuse even the slightest risk. Communication on medications is subject to regulatory or legal requirements, often uses tools and messages that are not adapted to the target audience and is often based on a poor knowledge of communication techniques. In order to improve this situation, the available information must be coordinated by reinforcing the unique medication information website and by coordinating communication between authorities by means of a single spokesperson. A particular effort must be made in the field of training in the proper use and risk of medications for both the general population and patients but also for healthcare professionals, by setting up a unified academic on-line teaching platform for continuing medical education on medications and their proper use.

  4. Information and communication on risks related to medications and proper use of medications for healthcare professionals and the general public: precautionary principle, risk management, communication during and in the absence of crisis situations.

    PubMed

    Molimard, Mathieu; Bernaud, Corine; Lechat, Philippe; Bejan-Angoulvant, Theodora; Benattia, Cherif; Benkritly, Amel; Braunstein, David; Cabut, Sandrine; David, Nadine; Fourrier-Réglat, Annie; Gallet, Benoit; Gersberg, Marta; Goni, Sylvia; Jolliet, Pascale; Lamarque-Garnier, Véronique; Le Jeunne, Claire; Leurs, Irina; Liard, François; Malbezin, Muriel; Micallef, Joelle; Nguon, Marina

    2014-01-01

    Recent drug crises have highlighted the complexity, benefits and risks of medication communication. The difficulty of this communication is due to the diversity of the sources of information and the target audience, the credibility of spokespersons, the difficulty to communicate on scientific uncertainties and the precautionary principle, which is influenced by variable perceptions and tolerances of the risk. Globally, there is a lack of training in risk management with a tendency of modern society to refuse even the slightest risk. Communication on medications is subject to regulatory or legal requirements, often uses tools and messages that are not adapted to the target audience and is often based on a poor knowledge of communication techniques. In order to improve this situation, the available information must be coordinated by reinforcing the unique medication information website and by coordinating communication between authorities by means of a single spokesperson. A particular effort must be made in the field of training in the proper use and risk of medications for both the general population and patients but also for healthcare professionals, by setting up a unified academic on-line teaching platform for continuing medical education on medications and their proper use. PMID:25099666

  5. Principles of programming languages: design

    SciTech Connect

    MacLennan, B.J.

    1983-01-01

    An excellent pedagogically oriented text on programming languages in which principles are emphasized more than details, methods more than results, and semantics more than syntax. Many chapter exercises, uniquely constructed and worded. Contents: Emphasis on efficiency: FORTRAN. Elegance and generality: ALGOL-60. Syntactic issues: ALGOL-60. Modularity and data abstraction: ADA. List processing LISP. Object-oriented programming. SMALLTALK. Logic programming: PROLOG. INDEX.

  6. Chemical Principles Revisited: Chemical Equilibrium.

    ERIC Educational Resources Information Center

    Mickey, Charles D.

    1980-01-01

    Describes: (1) Law of Mass Action; (2) equilibrium constant and ideal behavior; (3) general form of the equilibrium constant; (4) forward and reverse reactions; (5) factors influencing equilibrium; (6) Le Chatelier's principle; (7) effects of temperature, changing concentration, and pressure on equilibrium; and (8) catalysts and equilibrium. (JN)

  7. Developmental Principles: Fact or Fiction

    PubMed Central

    Durston, A. J.

    2012-01-01

    While still at school, most of us are deeply impressed by the underlying principles that so beautifully explain why the chemical elements are ordered as they are in the periodic table, and may wonder, with the theoretician Brian Goodwin, “whether there might be equally powerful principles that account for the awe-inspiring diversity of body forms in the living realm”. We have considered the arguments for developmental principles, conclude that they do exist and have specifically identified features that may generate principles associated with Hox patterning of the main body axis in bilaterian metazoa in general and in the vertebrates in particular. We wonder whether this exercise serves any purpose. The features we discuss were already known to us as parts of developmental mechanisms and defining developmental principles (how, and at which level?) adds no insight. We also see little profit in the proposal by Goodwin that there are principles outside the emerging genetic mechanisms that need to be taken into account. The emerging developmental genetic hierarchies already reveal a wealth of interesting phenomena, whatever we choose to call them. PMID:22489210

  8. Compound Verbs in Persian: An Euphemistic Phraseology.

    ERIC Educational Resources Information Center

    Salies, Tania Gastao

    An analysis of the compound verb system of Persian marks constructions euphemistically by producing an indirect order effect and by alternating different compound and simple forms that bear the same denotation but are governed by a rigorous code of ethics. What really carries the semantic reference in these cases is the process of construing…

  9. Principle of least wave change.

    PubMed

    Abramson, N

    1989-05-01

    Fermat's principle of least time has some well-known limitations. It does not, for example, apply to diffraction gratings and holograms, because it does not include the concept of waves. The substitution of least number of waves in flight for least time of flight and the addition of a term that is a function of the grating frequency result in a generalized principle. It is easy to remember because it is based on only the number of waves minus the number of grooves, and it would be especially useful when refraction and diffraction are combined, as, for example, in some holographic optical elements. PMID:2723846

  10. Kepler and Mach's Principle

    NASA Astrophysics Data System (ADS)

    Barbour, Julian

    The definitive ideas that led to the creation of general relativity crystallized in Einstein's thinking during 1912 while he was in Prague. At the centenary meeting held there to mark the breakthrough, I was asked to talk about earlier great work of relevance to dynamics done at Prague, above all by Kepler and Mach. The main topics covered in this chapter are: some little known but basic facts about the planetary motions; the conceptual framework and most important discoveries of Ptolemy and Copernicus; the complete change of concepts that Kepler introduced and their role in his discoveries; the significance of them in Newton's work; Mach's realization that Kepler's conceptual revolution needed further development to free Newton's conceptual world of the last vestiges of the purely geometrical Ptolemaic world view; and the precise formulation of Mach's principle required to place GR correctly in the line of conceptual and technical evolution that began with the ancient Greek astronomers.

  11. Accounting Principles 30G. Interim Guide.

    ERIC Educational Resources Information Center

    Manitoba Dept. of Education and Training, Winnipeg.

    This curriculum guide was developed for a senior-level introductory accounting course for students in high schools in Manitoba. The course introduces Canadian accounting principles and practices; it applies Generally Accepted Accounting Principles (GAAP) to introductory financial accounting. The guide includes the following components: (1) an…

  12. On nonholonomic systems and variational principles

    NASA Astrophysics Data System (ADS)

    Cronström, Christofer; Raita, Tommi

    2009-04-01

    We consider the compatibility of the equations of motion which follow from d'Alembert's principle in the case of a general autonomous nonholonomic mechanical system in N dimensions with those equations which follow for the same system by assuming the validity of a specific variational action principle, in which the nonholonomic conditions are implemented by means of the multiplication rule in the calculus of variations. The equations of motion which follow from the principle of d'Alembert are not identical to the equations which follow from the variational action principle. We give a proof that the solutions to the equations of motion which follow from d'Alembert's principle do not in general satisfy the equations which follow from the action principle with nonholonomic constraints. Thus the principle of d'Alembert and the minimal action principle involving the multiplication rule are not compatible in the case of systems with nonholonomic constraints. For simplicity the proof is given for autonomous systems only, with one general nonholonomic constraint, which is linear in the generalized velocities of the system.

  13. Hooke's Law: Applications of a Recurring Principle

    ERIC Educational Resources Information Center

    Giuliodori, Mauricio J.; Lujan, Heidi L.; Briggs, Whitney S.; Palani, Gurunanthan; DiCarlo, Stephen E.

    2009-01-01

    Students generally approach topics in physiology as a series of unrelated phenomena that share few underlying principles. However, if students recognized that the same underlying principles can be used to explain many physiological phenomena, they may gain a more unified understanding of physiological systems. To address this concern, we…

  14. How Many Principles for Public Health Ethics?

    PubMed

    Coughlin, Steven S

    2008-01-01

    General moral (ethical) principles play a prominent role in certain methods of moral reasoning and ethical decision-making in bioethics and public health. Examples include the principles of respect for autonomy, beneficence, nonmaleficence, and justice. Some accounts of ethics in public health have pointed to additional principles related to social and environmental concerns, such as the precautionary principle and principles of solidarity or social cohesion. This article provides an overview of principle-based methods of moral reasoning as they apply to public health ethics including a summary of advantages and disadvantages of methods of moral reasoning that rely upon general principles of moral reasoning. Drawing upon the literature on public health ethics, examples are provided of additional principles, obligations, and rules that may be useful for analyzing complex ethical issues in public health. A framework is outlined that takes into consideration the interplay of ethical principles and rules at individual, community, national, and global levels. Concepts such as the precautionary principle and solidarity are shown to be useful to public health ethics to the extent that they can be shown to provide worthwhile guidance and information above and beyond principles of beneficence, nonmaleficence, and justice, and the clusters of rules and maxims that are linked to these moral principles. Future directions likely to be productive include further work on areas of public health ethics such as public trust, community empowerment, the rights of individuals who are targeted (or not targeted) by public health interventions, individual and community resilience and wellbeing, and further clarification of principles, obligations, and rules in public health disciplines such as environmental science, prevention and control of chronic and infectious diseases, genomics, and global health. PMID:20072707

  15. How Many Principles for Public Health Ethics?

    PubMed Central

    Coughlin, Steven S.

    2009-01-01

    General moral (ethical) principles play a prominent role in certain methods of moral reasoning and ethical decision-making in bioethics and public health. Examples include the principles of respect for autonomy, beneficence, nonmaleficence, and justice. Some accounts of ethics in public health have pointed to additional principles related to social and environmental concerns, such as the precautionary principle and principles of solidarity or social cohesion. This article provides an overview of principle-based methods of moral reasoning as they apply to public health ethics including a summary of advantages and disadvantages of methods of moral reasoning that rely upon general principles of moral reasoning. Drawing upon the literature on public health ethics, examples are provided of additional principles, obligations, and rules that may be useful for analyzing complex ethical issues in public health. A framework is outlined that takes into consideration the interplay of ethical principles and rules at individual, community, national, and global levels. Concepts such as the precautionary principle and solidarity are shown to be useful to public health ethics to the extent that they can be shown to provide worthwhile guidance and information above and beyond principles of beneficence, nonmaleficence, and justice, and the clusters of rules and maxims that are linked to these moral principles. Future directions likely to be productive include further work on areas of public health ethics such as public trust, community empowerment, the rights of individuals who are targeted (or not targeted) by public health interventions, individual and community resilience and wellbeing, and further clarification of principles, obligations, and rules in public health disciplines such as environmental science, prevention and control of chronic and infectious diseases, genomics, and global health. PMID:20072707

  16. Principles of project management

    NASA Technical Reports Server (NTRS)

    1982-01-01

    The basic principles of project management as practiced by NASA management personnel are presented. These principles are given as ground rules and guidelines to be used in the performance of research, development, construction or operational assignments.

  17. Intuitions, principles and consequences.

    PubMed

    Shaw, A B

    2001-02-01

    Some approaches to the assessment of moral intuitions are discussed. The controlled ethical trial isolates a moral issue from confounding factors and thereby clarifies what a person's intuition actually is. Casuistic reasoning from situations, where intuitions are clear, suggests or modifies principles, which can then help to make decisions in situations where intuitions are unclear. When intuitions are defended by a supporting principle, that principle can be tested by finding extreme cases, in which it is counterintuitive to follow the principle. An approach to the resolution of conflict between valid moral principles, specifically the utilitarian and justice principles, is considered. It is argued that even those who justify intuitions by a priori principles are often obliged to modify or support their principles by resort to the consideration of consequences.

  18. Chemical Principls Exemplified

    ERIC Educational Resources Information Center

    Plumb, Robert C.

    1973-01-01

    Two topics are discussed: (1) Stomach Upset Caused by Aspirin, illustrating principles of acid-base equilibrium and solubility; (2) Physical Chemistry of the Drinking Duck, illustrating principles of phase equilibria and thermodynamics. (DF)

  19. Magnetism: Principles and Applications

    NASA Astrophysics Data System (ADS)

    Craik, Derek J.

    2003-09-01

    If you are studying physics, chemistry, materials science, electrical engineering, information technology or medicine, then you'll know that understanding magnetism is fundamental to success in your studies and here is the key to unlocking the mysteries of magnetism....... You can: obtain a simple overview of magnetism, including the roles of B and H, resonances and special techniques take full advantage of modern magnets with a wealth of expressions for fields and forces develop realistic general design programmes using isoparametric finite elements study the subtleties of the general theory of magnetic moments and their dynamics follow the development of outstanding materials appreciate how magnetism encompasses topics as diverse as rock magnetism, chemical reaction rates, biological compasses, medical therapies, superconductivity and levitation understand the basis and remarkable achievements of magnetic resonance imaging In his new book, Magnetism, Derek Craik throws light on the principles and applications of this fascinating subject. From formulae for calculating fields to quantum theory, the secrets of magnetism are exposed, ensuring that whether you are a chemist or engineer, physicist, medic or materials scientist Magnetism is the book for our course.

  20. Principles of Modern Soccer.

    ERIC Educational Resources Information Center

    Beim, George

    This book is written to give a better understanding of the principles of modern soccer to coaches and players. In nine chapters the following elements of the game are covered: (1) the development of systems; (2) the principles of attack; (3) the principles of defense; (4) training games; (5) strategies employed in restarts; (6) physical fitness…

  1. Chemical Principles Exemplified

    ERIC Educational Resources Information Center

    Plumb, Robert C.

    1970-01-01

    This is the first of a new series of brief ancedotes about materials and phenomena which exemplify chemical principles. Examples include (1) the sea-lab experiment illustrating principles of the kinetic theory of gases, (2) snow-making machines illustrating principles of thermodynamics in gas expansions and phase changes, and (3) sunglasses that…

  2. Energy principles in architectural design

    SciTech Connect

    Dean, E.

    1981-01-01

    A foundation of basic information pertaining to design and energy use in buildings is presented with emphasis on principles and concepts rather than applications of particular solution. Energy impacts of landforms and topography, vegetation, wind and ventilation, and sun on planning and designing the site are discused. General design considerations involving passive heating, cooling, and lighting systems are detailed. For the design of active building systems, heating, cooling, lighting, and HVAC systems are described. (MCW)

  3. 17 CFR 37.6 - Compliance with core principles.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... principles. 37.6 Section 37.6 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION DERIVATIVES TRANSACTION EXECUTION FACILITIES § 37.6 Compliance with core principles. (a) In general. To... transaction execution facility must have the capacity to be, and be, in compliance with the core principles...

  4. 17 CFR 37.6 - Compliance with core principles.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... principles. 37.6 Section 37.6 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION DERIVATIVES TRANSACTION EXECUTION FACILITIES § 37.6 Compliance with core principles. (a) In general. To... transaction execution facility must have the capacity to be, and be, in compliance with the core principles...

  5. Maximum principles for second order dynamic equations on time scales

    NASA Astrophysics Data System (ADS)

    Stehlik, Petr; Thompson, Bevan

    2007-07-01

    This paper establishes some new maximum principles for second order dynamic equations on time scales, including: a strong maximum principle; a generalized maximum principle; and a boundary point lemma. The new results include, as special cases, well-known ideas for ordinary differential equations and difference equations.

  6. 47 CFR 36.2 - Fundamental principles underlying procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...-kilometers is the basic fundamental allocation factor for interexchange circuit plant and exchange trunk... 47 Telecommunication 2 2010-10-01 2010-10-01 false Fundamental principles underlying procedures... Fundamental principles underlying procedures. (a) The following general principles underlie the...

  7. Complementary Huygens Principle for Geometrical and Nongeometrical Optics

    ERIC Educational Resources Information Center

    Luis, Alfredo

    2007-01-01

    We develop a fundamental principle depicting the generalized ray formulation of optics provided by the Wigner function. This principle is formally identical to the Huygens-Fresnel principle but in terms of opposite concepts, rays instead of waves, and incoherent superpositions instead of coherent ones. This ray picture naturally includes…

  8. Communication: General Semantics Perspectives.

    ERIC Educational Resources Information Center

    Thayer, Lee, Ed.

    This book contains the edited papers from the eleventh International Conference on General Semantics, titled "A Search for Relevance." The conference questioned, as a central theme, the relevance of general semantics in a world of wars and human misery. Reacting to a fundamental Korzybski-ian principle that man's view of reality is distorted by…

  9. The Principle of Energetic Consistency

    NASA Technical Reports Server (NTRS)

    Cohn, Stephen E.

    2009-01-01

    A basic result in estimation theory is that the minimum variance estimate of the dynamical state, given the observations, is the conditional mean estimate. This result holds independently of the specifics of any dynamical or observation nonlinearity or stochasticity, requiring only that the probability density function of the state, conditioned on the observations, has two moments. For nonlinear dynamics that conserve a total energy, this general result implies the principle of energetic consistency: if the dynamical variables are taken to be the natural energy variables, then the sum of the total energy of the conditional mean and the trace of the conditional covariance matrix (the total variance) is constant between observations. Ensemble Kalman filtering methods are designed to approximate the evolution of the conditional mean and covariance matrix. For them the principle of energetic consistency holds independently of ensemble size, even with covariance localization. However, full Kalman filter experiments with advection dynamics have shown that a small amount of numerical dissipation can cause a large, state-dependent loss of total variance, to the detriment of filter performance. The principle of energetic consistency offers a simple way to test whether this spurious loss of variance limits ensemble filter performance in full-blown applications. The classical second-moment closure (third-moment discard) equations also satisfy the principle of energetic consistency, independently of the rank of the conditional covariance matrix. Low-rank approximation of these equations offers an energetically consistent, computationally viable alternative to ensemble filtering. Current formulations of long-window, weak-constraint, four-dimensional variational methods are designed to approximate the conditional mode rather than the conditional mean. Thus they neglect the nonlinear bias term in the second-moment closure equation for the conditional mean. The principle of

  10. Hamilton's Principle for Beginners

    ERIC Educational Resources Information Center

    Brun, J. L.

    2007-01-01

    I find that students have difficulty with Hamilton's principle, at least the first time they come into contact with it, and therefore it is worth designing some examples to help students grasp its complex meaning. This paper supplies the simplest example to consolidate the learning of the quoted principle: that of a free particle moving along a…

  11. A critique of principlism.

    PubMed

    Clouser, K D; Gert, B

    1990-04-01

    The authors use the term "principlism" to refer to the practice of using "principles" to replace both moral theory and particular moral rules and ideals in dealing with the moral problems that arise in medical practice. The authors argue that these "principles" do not function as claimed, and that their use is misleading both practically and theoretically. The "principles" are in fact not guides to action, but rather they are merely names for a collection of sometimes superficially related matters for consideration when dealing with a moral problem. The "principles" lack any systematic relationship to each other, and they often conflict with each other. These conflicts are unresolvable, since there is no unified moral theory from which they are all derived. For comparison the authors sketch the advantages of using a unified moral theory. PMID:2351895

  12. [The precautionary principle and the environment].

    PubMed

    de Cózar Escalante, José Manuel

    2005-01-01

    The precautionary principle is a response to uncertainty in the face of risks to health or the environment. In general, it involves taking measures to avoid potential harm, despite lack of scientific certainty. In recent years it has been applied, not without difficulties, as a legal and political principle in many countries, particularly on the European and International level. In spite of the controversy, the precautionary principle has become an integral component of a new paradigm for the creation of public policies needed to meet today's challenges and those of the future.

  13. A New Principle in Physiscs: the Principle "Finiteness", and Some Consequences

    SciTech Connect

    Abraham Sternlieb

    2010-06-25

    In this paper I propose a new principle in physics: the principle of "finiteness". It stems from the definition of physics as a science that deals (among other things) with measurable dimensional physical quantities. Since measurement results, including their errors, are always finite, the principle of finiteness postulates that the mathematical formulation of "legitimate" laws of physics should prevent exactly zero or infinite solutions. Some consequences of the principle of finiteness are discussed, in general, and then more specifically in the fields of special relativity, quantum mechanics, and quantum gravity. The consequences are derived independently of any other theory or principle in physics. I propose "finiteness" as a postulate (like the constancy of the speed of light in vacuum, "c"), as opposed to a notion whose validity has to be corroborated by, or derived theoretically or experimentally from other facts, theories, or principles.

  14. Probing Students' Ideas of the Principle of Equivalence

    ERIC Educational Resources Information Center

    Bandyopadhyay, Atanu; Kumar, Arvind

    2011-01-01

    The principle of equivalence was the first vital clue to Einstein in his extension of special relativity to general relativity, the modern theory of gravitation. In this paper we investigate in some detail students' understanding of this principle in a variety of contexts, when they are undergoing an introductory course on general relativity. The…

  15. 46 CFR 232.2 - General instructions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... other regulatory agencies, or reports using other acceptable accounting methods differing from methods... accepted accounting principles. All contractors shall conform their accounting policies to generally accepted accounting principles (promulgated by the Financial Accounting Standards Board of the...

  16. Artificial intelligence: Principles and applications

    SciTech Connect

    Yazdani, M.

    1986-01-01

    Following the Japanese announcement that they intend to devise, make, and market, in the 1990s, computers incorporating a level of intelligence, a vast amount of energy and expense has been diverted at the field of Artificial Intelligence. Workers for the past 25 years in this discipline have tried to reproduce human behavior on computers and this book presents their achievements and the problems. Subjects include: computer vision, speech processing, robotics, natural language processing expert systems and machine learning. The book also attempts to show the general principles behind the various applications and finally attempts to show their implications for other human endeavors such as philosophy, psychology, and the development of modern society.

  17. Political tolerance of homosexuals: the role of group attitudes and legal principles.

    PubMed

    Riggle, E D; Ellis, A L

    1994-01-01

    Individuals' attitudes toward and acceptance of general legal principles were assessed along with their willingness to extend application of these principles to various social and political groups, including homosexuals. Respondents then indicated their attitudes toward various social and political groups, including the groups to whom they had applied the general principles. Regression analyses were used to determine to what degree acceptance of the general principle and attitude toward the social group predicted application of the general principle to the group. For disliked groups such as the Ku Klux Klan and Nazis, individuals' acceptance of the general principle alone predicted the specific application. For homosexuals, however, the application of the general principle was affected both by acceptance of the general principle and by individuals' attitudes toward homosexuals. The implications of this difference in light of research addressing the cognitive and affective nature of attitudes and attitude change is discussed. PMID:8006417

  18. Archimedes' Principle in Action

    ERIC Educational Resources Information Center

    Kires, Marian

    2007-01-01

    The conceptual understanding of Archimedes' principle can be verified in experimental procedures which determine mass and density using a floating object. This is demonstrated by simple experiments using graduated beakers. (Contains 5 figures.)

  19. Chemical Principles Exemplified

    ERIC Educational Resources Information Center

    Plumb, Robert C.

    1972-01-01

    Collection of two short descriptions of chemical principles seen in life situations: the autocatalytic reaction seen in the bombardier beetle, and molecular potential energy used for quick roasting of beef. Brief reference is also made to methanol lighters. (PS)

  20. Archimedes' principle in action

    NASA Astrophysics Data System (ADS)

    Kireš, Marián

    2007-09-01

    The conceptual understanding of Archimedes' principle can be verified in experimental procedures which determine mass and density using a floating object. This is demonstrated by simple experiments using graduated beakers.

  1. Ethical principles and concepts in medicine.

    PubMed

    Taylor, Robert M

    2013-01-01

    Clinical ethics is the application of ethical theories, principles, rules, and guidelines to clinical situations in medicine. Therefore, clinical ethics is analogous to clinical medicine in that general principles and concepts must be applied intelligently and thoughtfully to unique clinical circumstances. The three major ethical theories are consequentialism, whereby the consequences of an action determine whether it is ethical; deontology, whereby to be ethical is to do one's duty, and virtue ethics, whereby ethics is a matter of cultivating appropriate virtues. In the real world of medicine, most people find that all three perspectives offer useful insights and are complementary rather than contradictory. The most common approach to clinical ethical analysis is principlism. According to principlism, the medical practitioner must attempt to uphold four important principles: respect for patient autonomy, beneficence, nonmaleficence, and justice. When these principles conflict, resolving them depends on the details of the case. Alternative approaches to medical ethics, including the primacy of beneficence, care-based ethics, feminist ethics, and narrative ethics, help to define the limitations of principlism and provide a broader perspective on medical ethics.

  2. The traveltime holographic principle

    NASA Astrophysics Data System (ADS)

    Huang, Yunsong; Schuster, Gerard T.

    2015-01-01

    Fermat's interferometric principle is used to compute interior transmission traveltimes τpq from exterior transmission traveltimes τsp and τsq. Here, the exterior traveltimes are computed for sources s on a boundary B that encloses a volume V of interior points p and q. Once the exterior traveltimes are computed, no further ray tracing is needed to calculate the interior times τpq. Therefore this interferometric approach can be more efficient than explicitly computing interior traveltimes τpq by ray tracing. Moreover, the memory requirement of the traveltimes is reduced by one dimension, because the boundary B is of one fewer dimension than the volume V. An application of this approach is demonstrated with interbed multiple (IM) elimination. Here, the IMs in the observed data are predicted from the migration image and are subsequently removed by adaptive subtraction. This prediction is enabled by the knowledge of interior transmission traveltimes τpq computed according to Fermat's interferometric principle. We denote this principle as the `traveltime holographic principle', by analogy with the holographic principle in cosmology where information in a volume is encoded on the region's boundary.

  3. Spaceborne receivers: Basic principles

    NASA Technical Reports Server (NTRS)

    Stacey, J. M.

    1984-01-01

    The underlying principles of operation of microwave receivers for space observations of planetary surfaces were examined. The design philosophy of the receiver as it is applied to operate functionally as an efficient receiving system, the principle of operation of the key components of the receiver, and the important differences among receiver types are explained. The operating performance and the sensitivity expectations for both the modulated and total power receiver configurations are outlined. The expressions are derived from first principles and are developed through the important intermediate stages to form practicle and easily applied equations. The transfer of thermodynamic energy from point to point within the receiver is illustrated. The language of microwave receivers is applied statistics.

  4. Teaching/learning principles

    NASA Technical Reports Server (NTRS)

    Hankins, D. B.; Wake, W. H.

    1981-01-01

    The potential remote sensing user community is enormous, and the teaching and training tasks are even larger; however, some underlying principles may be synthesized and applied at all levels from elementary school children to sophisticated and knowledgeable adults. The basic rules applying to each of the six major elements of any training course and the underlying principle involved in each rule are summarized. The six identified major elements are: (1) field sites for problems and practice; (2) lectures and inside study; (3) learning materials and resources (the kit); (4) the field experience; (5) laboratory sessions; and (6) testing and evaluation.

  5. 5 CFR 551.401 - Basic principles.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... FAIR LABOR STANDARDS ACT Hours of Work General Provisions § 551.401 Basic principles. (a) All time... or in excess of another applicable overtime work standard under section 7(k) of the Fair Labor Standards Act, agencies shall credit hours of work under § 410.402 of this chapter, part 532 of this...

  6. 5 CFR 551.401 - Basic principles.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... FAIR LABOR STANDARDS ACT Hours of Work General Provisions § 551.401 Basic principles. (a) All time... or in excess of another applicable overtime work standard under section 7(k) of the Fair Labor Standards Act, agencies shall credit hours of work under § 410.402 of this chapter, part 532 of this...

  7. 5 CFR 551.401 - Basic principles.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... FAIR LABOR STANDARDS ACT Hours of Work General Provisions § 551.401 Basic principles. (a) All time... or in excess of another applicable overtime work standard under section 7(k) of the Fair Labor Standards Act, agencies shall credit hours of work under § 410.402 of this chapter, part 532 of this...

  8. 5 CFR 551.401 - Basic principles.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... FAIR LABOR STANDARDS ACT Hours of Work General Provisions § 551.401 Basic principles. (a) All time... or in excess of another applicable overtime work standard under section 7(k) of the Fair Labor Standards Act, agencies shall credit hours of work under § 410.402 of this chapter, part 532 of this...

  9. 5 CFR 551.401 - Basic principles.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... FAIR LABOR STANDARDS ACT Hours of Work General Provisions § 551.401 Basic principles. (a) All time... or in excess of another applicable overtime work standard under section 7(k) of the Fair Labor Standards Act, agencies shall credit hours of work under § 410.402 of this chapter, part 532 of this...

  10. 7 CFR 2500.021 - Guiding principles.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Guiding principles. 2500.021 Section 2500.021 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF ADVOCACY AND OUTREACH, DEPARTMENT OF AGRICULTURE OAO FEDERAL FINANCIAL ASSISTANCE PROGRAMS-GENERAL AWARD ADMINISTRATIVE...

  11. 7 CFR 2500.021 - Guiding principles.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Guiding principles. 2500.021 Section 2500.021 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF ADVOCACY AND OUTREACH, DEPARTMENT OF AGRICULTURE OAO FEDERAL FINANCIAL ASSISTANCE PROGRAMS-GENERAL AWARD ADMINISTRATIVE...

  12. 7 CFR 2500.021 - Guiding principles.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Guiding principles. 2500.021 Section 2500.021 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF ADVOCACY AND OUTREACH, DEPARTMENT OF AGRICULTURE OAO FEDERAL FINANCIAL ASSISTANCE PROGRAMS-GENERAL AWARD ADMINISTRATIVE...

  13. Principles for Teaching Problem Solving. Technical Paper.

    ERIC Educational Resources Information Center

    Foshay, Rob; Kirkley, Jamie

    This Technical Paper focuses on principles for teaching problem solving. Part 1 addresses the need to teach problem solving. Part 2 defines problem solving skills, and describes: general problem solving models of the 1960s and 1970s, current problem solving models, declarative knowledge, mental models, expert versus novice knowledge, procedural…

  14. 43 CFR 1601.0-8 - Principles.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Principles. 1601.0-8 Section 1601.0-8 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR GENERAL MANAGEMENT (1000) PLANNING, PROGRAMMING, BUDGETING Planning §...

  15. 43 CFR 1601.0-8 - Principles.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Principles. 1601.0-8 Section 1601.0-8 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR GENERAL MANAGEMENT (1000) PLANNING, PROGRAMMING, BUDGETING Planning §...

  16. 43 CFR 1601.0-8 - Principles.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Principles. 1601.0-8 Section 1601.0-8 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR GENERAL MANAGEMENT (1000) PLANNING, PROGRAMMING, BUDGETING Planning §...

  17. 43 CFR 1601.0-8 - Principles.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Principles. 1601.0-8 Section 1601.0-8 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR GENERAL MANAGEMENT (1000) PLANNING, PROGRAMMING, BUDGETING Planning §...

  18. The 5-Step Method: Principles and Practice

    ERIC Educational Resources Information Center

    Copello, Alex; Templeton, Lorna; Orford, Jim; Velleman, Richard

    2010-01-01

    This article includes a description of the 5-Step Method. First, the origins and theoretical basis of the method are briefly described. This is followed by a discussion of the general principles that guide the delivery of the method. Each step is then described in more detail, including the content and focus of each of the five steps that include:…

  19. Standards for Quality? A Citical Appraisal of the Berlin Principles for International Rankings of Universities

    ERIC Educational Resources Information Center

    Hägg, Ingemund; Wedlin, Linda

    2013-01-01

    This article discusses the principles developed to assure the quality of international ranking practices for higher education, the so-called Berlin Principles, and the role given to them in the higher education community. While the principles are generally regarded as proper quality assurance principles, they are problematic both in their content…

  20. Principles of sound ecotoxicology.

    PubMed

    Harris, Catherine A; Scott, Alexander P; Johnson, Andrew C; Panter, Grace H; Sheahan, Dave; Roberts, Mike; Sumpter, John P

    2014-03-18

    We have become progressively more concerned about the quality of some published ecotoxicology research. Others have also expressed concern. It is not uncommon for basic, but extremely important, factors to apparently be ignored. For example, exposure concentrations in laboratory experiments are sometimes not measured, and hence there is no evidence that the test organisms were actually exposed to the test substance, let alone at the stated concentrations. To try to improve the quality of ecotoxicology research, we suggest 12 basic principles that should be considered, not at the point of publication of the results, but during the experimental design. These principles range from carefully considering essential aspects of experimental design through to accurately defining the exposure, as well as unbiased analysis and reporting of the results. Although not all principles will apply to all studies, we offer these principles in the hope that they will improve the quality of the science that is available to regulators. Science is an evidence-based discipline and it is important that we and the regulators can trust the evidence presented to us. Significant resources often have to be devoted to refuting the results of poor research when those resources could be utilized more effectively.

  1. Extended Mach Principle.

    ERIC Educational Resources Information Center

    Rosen, Joe

    1981-01-01

    Discusses the meaning of symmetry of the laws of physics and symmetry of the universe and the connection between symmetries and asymmetries of the laws of physics and those of the universe. An explanation of Hamilton's principle is offered. The material is suitable for informal discussions with students. (Author/SK)

  2. Matters of Principle.

    ERIC Educational Resources Information Center

    Martz, Carlton

    1999-01-01

    This issue of "Bill of Rights in Action" looks at individuals who have stood on principle against authority or popular opinion. The first article investigates John Adams and his defense of British soldiers at the Boston Massacre trials. The second article explores Archbishop Thomas Becket's fatal conflict with England's King Henry II. The final…

  3. The Denver principles.

    PubMed

    2000-01-01

    The Denver principles articulate the self empowerment movement of People With AIDS (PWA). The statements, written in 1983 by the Advisory Committee of the People With AIDS, include recommendations on how to support those with disease. It also includes suggestions for people who have AIDS. It concludes by listing the "rights of people with AIDS."

  4. Reprographic Principles Made Easy.

    ERIC Educational Resources Information Center

    Young, J. B.

    Means for reproducing graphic materials are explained. There are several types of processes: those using light sensitive material, those using heat sensitive material, those using photo conductive materials (electrophotography), and duplicating processes using ink. For each of these, the principles behind them are explained, the necessary…

  5. The Idiom Principle Revisited

    ERIC Educational Resources Information Center

    Siyanova-Chanturia, Anna; Martinez, Ron

    2015-01-01

    John Sinclair's Idiom Principle famously posited that most texts are largely composed of multi-word expressions that "constitute single choices" in the mental lexicon. At the time that assertion was made, little actual psycholinguistic evidence existed in support of that holistic, "single choice," view of formulaic language. In…

  6. Principles of Biomedical Ethics

    PubMed Central

    Athar, Shahid

    2012-01-01

    In this presentation, I will discuss the principles of biomedical and Islamic medical ethics and an interfaith perspective on end-of-life issues. I will also discuss three cases to exemplify some of the conflicts in ethical decision-making. PMID:23610498

  7. Principles of Teaching. Module.

    ERIC Educational Resources Information Center

    Rhoades, Joseph W.

    This module on principles of teaching is 1 in a series of 10 modules written for vocational education teacher education programs. It is designed to enable the teacher to do the following: (1) identify subject matter and integrate that subject matter with thought-provoking questions; (2) organize and demonstrate good questioning techniques; and (3)…

  8. Basic Comfort Heating Principles.

    ERIC Educational Resources Information Center

    Dempster, Chalmer T.

    The material in this beginning book for vocational students presents fundamental principles needed to understand the heating aspect of the sheet metal trade and supplies practical experience to the student so that he may become familiar with the process of determining heat loss for average structures. Six areas covered are: (1) Background…

  9. Hydrogen evolution: Guiding principles

    NASA Astrophysics Data System (ADS)

    Xia, Zhenhai

    2016-10-01

    Lower-cost alternatives to platinum electrocatalysts are being explored for the sustainable production of hydrogen, but often trial-and-error approaches are used for their development. Now, principles are elucidated that suggest pathways to rationally design efficient metal-free electrocatalysts based on doped graphene.

  10. General Drafting. Technical Manual.

    ERIC Educational Resources Information Center

    Department of the Army, Washington, DC.

    The manual provides instructional guidance and reference material in the principles and procedures of general drafting and constitutes the primary study text for personnel in drafting as a military occupational specialty. Included is information on drafting equipment and its use; line weights, conventions and formats; lettering; engineering charts…

  11. Qualitative biomechanical principles for application in coaching.

    PubMed

    Knudson, Duane

    2007-01-01

    Many aspects of human movements in sport can be readily understood by Newtonian rigid-body mechanics. Many of these laws and biomechanical principles, however, are counterintuitive to a lot of people. There are also several problems in the application of biomechanics to sports, so the application of biomechanics in the qualitative analysis of sport skills by many coaches has been limited. Biomechanics scholars have long been interested in developing principles that facilitate the qualitative application of biomechanics to improve movement performance and reduce the risk of injury. This paper summarizes the major North American efforts to establish a set of general biomechanical principles of movement, and illustrates how principles can be used to improve the application of biomechanics in the qualitative analysis of sport technique. A coach helping a player with a tennis serve is presented as an example. The standardization of terminology for biomechanical principles is proposed as an important first step in improving the application ofbiomechanics in sport. There is also a need for international cooperation and research on the effectiveness of applying biomechanical principles in the coaching of sport techniques. PMID:17542182

  12. Le Chatelier's principle in replicator dynamics

    NASA Astrophysics Data System (ADS)

    Allahverdyan, Armen E.; Galstyan, Aram

    2011-10-01

    The Le Chatelier principle states that physical equilibria are not only stable, but they also resist external perturbations via short-time negative-feedback mechanisms: a perturbation induces processes tending to diminish its results. The principle has deep roots, e.g., in thermodynamics it is closely related to the second law and the positivity of the entropy production. Here we study the applicability of the Le Chatelier principle to evolutionary game theory, i.e., to perturbations of a Nash equilibrium within the replicator dynamics. We show that the principle can be reformulated as a majorization relation. This defines a stability notion that generalizes the concept of evolutionary stability. We determine criteria for a Nash equilibrium to satisfy the Le Chatelier principle and relate them to mutualistic interactions (game-theoretical anticoordination) showing in which sense mutualistic replicators can be more stable than (say) competing ones. There are globally stable Nash equilibria, where the Le Chatelier principle is violated even locally: in contrast to the thermodynamic equilibrium a Nash equilibrium can amplify small perturbations, though both types of equilibria satisfy the detailed balance condition.

  13. Le Chatelier's principle in replicator dynamics.

    PubMed

    Allahverdyan, Armen E; Galstyan, Aram

    2011-10-01

    The Le Chatelier principle states that physical equilibria are not only stable, but they also resist external perturbations via short-time negative-feedback mechanisms: a perturbation induces processes tending to diminish its results. The principle has deep roots, e.g., in thermodynamics it is closely related to the second law and the positivity of the entropy production. Here we study the applicability of the Le Chatelier principle to evolutionary game theory, i.e., to perturbations of a Nash equilibrium within the replicator dynamics. We show that the principle can be reformulated as a majorization relation. This defines a stability notion that generalizes the concept of evolutionary stability. We determine criteria for a Nash equilibrium to satisfy the Le Chatelier principle and relate them to mutualistic interactions (game-theoretical anticoordination) showing in which sense mutualistic replicators can be more stable than (say) competing ones. There are globally stable Nash equilibria, where the Le Chatelier principle is violated even locally: in contrast to the thermodynamic equilibrium a Nash equilibrium can amplify small perturbations, though both types of equilibria satisfy the detailed balance condition. PMID:22181097

  14. Code of ethics: principles for ethical leadership.

    PubMed

    Flite, Cathy A; Harman, Laurinda B

    2013-01-01

    The code of ethics for a professional association incorporates values, principles, and professional standards. A review and comparative analysis of a 1934 pledge and codes of ethics from 1957, 1977, 1988, 1998, 2004, and 2011 for a health information management association was conducted. Highlights of some changes in the healthcare delivery system are identified as a general context for the codes of ethics. The codes of ethics are examined in terms of professional values and changes in the language used to express the principles of the various codes.

  15. The equivalence principle in a quantum world

    NASA Astrophysics Data System (ADS)

    Bjerrum-Bohr, N. E. J.; Donoghue, John F.; El-Menoufi, Basem Kamal; Holstein, Barry R.; Planté, Ludovic; Vanhove, Pierre

    2015-09-01

    We show how modern methods can be applied to quantum gravity at low energy. We test how quantum corrections challenge the classical framework behind the equivalence principle (EP), for instance through introduction of nonlocality from quantum physics, embodied in the uncertainty principle. When the energy is small, we now have the tools to address this conflict explicitly. Despite the violation of some classical concepts, the EP continues to provide the core of the quantum gravity framework through the symmetry — general coordinate invariance — that is used to organize the effective field theory (EFT).

  16. Action principle for Coulomb collisions in plasmas

    DOE PAGES

    Hirvijoki, Eero

    2016-09-14

    In this study, an action principle for Coulomb collisions in plasmas is proposed. Although no natural Lagrangian exists for the Landau-Fokker-Planck equation, an Eulerian variational formulation is found considering the system of partial differential equations that couple the distribution function and the Rosenbluth-MacDonald-Judd potentials. Conservation laws are derived after generalizing the energy-momentum stress tensor for second order Lagrangians and, in the case of a test-particle population in a given plasma background, the action principle is shown to correspond to the Langevin equation for individual particles.

  17. Derivation of GFDM Based on OFDM Principles

    SciTech Connect

    Hussein Moradi; Behrouz Farhang-Boroujeny

    2015-06-01

    This paper starts with discussing the principle based on which the celebrated orthogonal frequency division multiplexing (OFDM) signals are constructed. It then extends the same principle to construct the newly introduced generalized frequency division multiplexing (GFDM) signals. This novel derivation sheds light on some interesting properties of GFDM. In particular, our derivation seamlessly leads to an implementation of GFDM transmitter which has significantly lower complexity than what has been reported so far. Our derivation also facilitates a trivial understanding of how GFDM (similar to OFDM) can be applied in MIMO channels.

  18. Action principle for Coulomb collisions in plasmas

    NASA Astrophysics Data System (ADS)

    Hirvijoki, Eero

    2016-09-01

    An action principle for Coulomb collisions in plasmas is proposed. Although no natural Lagrangian exists for the Landau-Fokker-Planck equation, an Eulerian variational formulation is found considering the system of partial differential equations that couple the distribution function and the Rosenbluth-MacDonald-Judd potentials. Conservation laws are derived after generalizing the energy-momentum stress tensor for second order Lagrangians and, in the case of a test-particle population in a given plasma background, the action principle is shown to correspond to the Langevin equation for individual particles.

  19. Curriculum structure: principles and strategy.

    PubMed

    Oliver, R; Kersten, H; Vinkka-Puhakka, H; Alpasan, G; Bearn, D; Cema, I; Delap, E; Dummer, P; Goulet, J P; Gugushe, T; Jeniati, E; Jerolimov, V; Kotsanos, N; Krifka, S; Levy, G; Neway, M; Ogawa, T; Saag, M; Sidlauskas, A; Skaleric, U; Vervoorn, M; White, D

    2008-02-01

    This report provides general guidelines for the structure of a curriculum, followed by specific advice on the principles of learning and teaching, the process of restructuring and change leadership and management. It provides examples of several educational philosophies, including vertical and horizontal integration. It discusses the use of competence, learning outcomes, level of degree and assessment and provides a number of recommendations. It does not seek to be prescriptive of time allocation to disciplines within a curriculum. Although this report has been written primarily for those who will develop an undergraduate curriculum, the information may be sufficiently generic to apply to the recent development in graduate entry ('shortened dental' or 'accelerated') courses and to postgraduate degree planning and higher education certificate or diploma courses for other dental care professionals (auxiliaries). The report may have a European bias as progress is made to converge and enhance educational standards in 29 countries with different educational approaches - a microcosm of global collaboration.

  20. First principles of Hamiltonian medicine.

    PubMed

    Crespi, Bernard; Foster, Kevin; Úbeda, Francisco

    2014-05-19

    We introduce the field of Hamiltonian medicine, which centres on the roles of genetic relatedness in human health and disease. Hamiltonian medicine represents the application of basic social-evolution theory, for interactions involving kinship, to core issues in medicine such as pathogens, cancer, optimal growth and mental illness. It encompasses three domains, which involve conflict and cooperation between: (i) microbes or cancer cells, within humans, (ii) genes expressed in humans, (iii) human individuals. A set of six core principles, based on these domains and their interfaces, serves to conceptually organize the field, and contextualize illustrative examples. The primary usefulness of Hamiltonian medicine is that, like Darwinian medicine more generally, it provides novel insights into what data will be productive to collect, to address important clinical and public health problems. Our synthesis of this nascent field is intended predominantly for evolutionary and behavioural biologists who aspire to address questions directly relevant to human health and disease.

  1. First principles of Hamiltonian medicine

    PubMed Central

    Crespi, Bernard; Foster, Kevin; Úbeda, Francisco

    2014-01-01

    We introduce the field of Hamiltonian medicine, which centres on the roles of genetic relatedness in human health and disease. Hamiltonian medicine represents the application of basic social-evolution theory, for interactions involving kinship, to core issues in medicine such as pathogens, cancer, optimal growth and mental illness. It encompasses three domains, which involve conflict and cooperation between: (i) microbes or cancer cells, within humans, (ii) genes expressed in humans, (iii) human individuals. A set of six core principles, based on these domains and their interfaces, serves to conceptually organize the field, and contextualize illustrative examples. The primary usefulness of Hamiltonian medicine is that, like Darwinian medicine more generally, it provides novel insights into what data will be productive to collect, to address important clinical and public health problems. Our synthesis of this nascent field is intended predominantly for evolutionary and behavioural biologists who aspire to address questions directly relevant to human health and disease. PMID:24686937

  2. Principles of Equilibrium Statistical Mechanics

    NASA Astrophysics Data System (ADS)

    Chowdhury, Debashish; Stauffer, Dietrich

    2000-09-01

    This modern textbook provides a complete survey of the broad field of statistical mechanics. Based on a series of lectures, it adopts a special pedagogical approach. The authors, both excellent lecturers, clearly distinguish between general principles and their applications in solving problems. Analogies between phase transitions in fluids and magnets using continuum and spin models are emphasized, leading to a better understanding. Such special features as historical notes, summaries, problems, mathematical appendix, computer programs and order of magnitude estimations distinguish this volume from competing works. Due to its ambitious level and an extensive list of references for technical details on advanced topics, this is equally a must for researchers in condensed matter physics, materials science, polymer science, solid state physics, and astrophysics. From the contents Thermostatics: phase stability, phase equilibria, phase transitions; Statistical Mechanics: calculation, correlation functions, ideal classical gases, ideal quantum gases; Interacting Systems: models, computer simulation, mean-field approximation; Interacting Systems beyond Mean-field Theory: scaling and renormalization group, foundations of statistical mechanics "The present book, however, is unique that it both is written in a very pedagogic, easily comprehensible style, and, nevertheless, goes from the basic principles all the way to these modern topics, containing several chapters on the various approaches of mean field theory, and a chapter on computer simulation. A characteristic feature of this book is that often first some qualitative arguments are given, or a "pedestrians's approach", and then a more general and/or more rigorous derivation is presented as well. Particularly useful are also "supplementary notes", pointing out interesting applications and further developments of the subject, a detailed bibliography, problems and historical notes, and many pedagogic figures."

  3. Principles of Glacier Mechanics

    NASA Astrophysics Data System (ADS)

    Waddington, Edwin D.

    Glaciers are awesome in size and move at a majestic pace, and they frequently occupy spectacular mountainous terrain. Naturally, many Earth scientists are attracted to glaciers. Some of us are even fortunate enough to make a career of studying glacier flow. Many others work on the large, flat polar ice sheets where there is no scenery. As a leader of one of the foremost research projects now studying the flow of mountain glaciers (Storglaciaren, Norway), Roger Hooke is well qualified to describe the principles of glacier mechanics. Principles of Glacier Mechanics is written for upper-level undergraduate students and graduate students with an interest in glaciers and the landforms that glaciers produce. While most of the examples in the text are drawn from valley glacier studies, much of the material is also relevant to “glacier flatland” on the polar ice sheets.

  4. 32 CFR 11.4 - Applicable principles of law.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Accused's acts. As provided in 32 CFR 9.5(c), the prosecution bears the burden of establishing the Accused... 32 National Defense 1 2010-07-01 2010-07-01 false Applicable principles of law. 11.4 Section 11.4... ELEMENTS FOR TRIALS BY MILITARY COMMISSION § 11.4 Applicable principles of law. (a) General intent....

  5. 41 CFR 101-5.303 - Guiding principles.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., the compensation of the employees of the health unit, and other factors of medical economics prevalent... System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 5-CENTRALIZED SERVICES IN FEDERAL BUILDINGS AND COMPLEXES 5.3-Federal Employee Health Services § 101-5.303 Guiding principles. The following principles...

  6. 41 CFR 101-5.303 - Guiding principles.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., the compensation of the employees of the health unit, and other factors of medical economics prevalent... System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 5-CENTRALIZED SERVICES IN FEDERAL BUILDINGS AND COMPLEXES 5.3-Federal Employee Health Services § 101-5.303 Guiding principles. The following principles...

  7. 41 CFR 101-5.303 - Guiding principles.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., the compensation of the employees of the health unit, and other factors of medical economics prevalent... System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 5-CENTRALIZED SERVICES IN FEDERAL BUILDINGS AND COMPLEXES 5.3-Federal Employee Health Services § 101-5.303 Guiding principles. The following principles...

  8. 41 CFR 101-5.303 - Guiding principles.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., the compensation of the employees of the health unit, and other factors of medical economics prevalent... System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 5-CENTRALIZED SERVICES IN FEDERAL BUILDINGS AND COMPLEXES 5.3-Federal Employee Health Services § 101-5.303 Guiding principles. The following principles...

  9. A Simple Model of Entrepreneurship for Principles of Economics Courses

    ERIC Educational Resources Information Center

    Gunter, Frank R.

    2012-01-01

    The critical roles of entrepreneurs in creating, operating, and destroying markets, as well as their importance in driving long-term economic growth are still generally either absent from principles of economics texts or relegated to later chapters. The primary difficulties in explaining entrepreneurship at the principles level are the lack of a…

  10. 17 CFR 37.6 - Compliance with core principles.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Compliance with core... DERIVATIVES TRANSACTION EXECUTION FACILITIES § 37.6 Compliance with core principles. (a) In general. To... transaction execution facility must have the capacity to be, and be, in compliance with the core principles...

  11. Ethical Principles of Psychologists and Code of Conduct.

    ERIC Educational Resources Information Center

    American Psychologist, 2002

    2002-01-01

    Describes the American Psychological Association's Ethical Principles of Psychologists and Code of Conduct, focusing on introduction and applicability; preamble; general principles; and ethical standards (resolving ethical issues, competence, human relations, privacy and confidentiality, advertising and other public statements, record keeping and…

  12. Principles and Practices for Championship Performances in Wheelchair Field Events.

    ERIC Educational Resources Information Center

    Practical Pointers, 1980

    1980-01-01

    The article discusses training and competing in wheelchair sports. General principles of training, including scheduling and content considerations, are listed. Principles for specific wheelchair events (shotput, discus, and javelin) are detailed. A final part addresses training for the wheelchair pentathlon, which includes archery, swimming,…

  13. Pauli Exclusion Principle

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    A principle of quantum theory, devised in 1925 by Wolfgang Pauli (1900-58), which states that no two fermions may exist in the same quantum state. The quantum state of a particle is defined by a set of numbers that describe quantities such as energy, angular momentum and spin. Fermions are particles such as quarks, protons, neutrons and electrons, that have spin = ½ (in units of h/2π, where h is ...

  14. Principles of nuclear geology

    SciTech Connect

    Aswathanarayana, U.

    1985-01-01

    This book treats the basic principles of nuclear physics and the mineralogy, geochemistry, distribution and ore deposits of uranium and thorium. The application of nuclear methodology in radiogenic heat and thermal regime of the earth, radiometric prospecting, isotopic age dating, stable isotopes and cosmic-ray produced isotopes is covered. Geological processes, such as metamorphic chronology, petrogenesis, groundwater movement, and sedimentation rate are focussed on.

  15. Principles of lake sedimentology

    SciTech Connect

    Janasson, L.

    1983-01-01

    This book presents a comprehensive outline on the basic sedimentological principles for lakes, and focuses on environmental aspects and matters related to lake management and control-on lake ecology rather than lake geology. This is a guide for those who plan, perform and evaluate lake sedimentological investigations. Contents abridged: Lake types and sediment types. Sedimentation in lakes and water dynamics. Lake bottom dynamics. Sediment dynamics and sediment age. Sediments in aquatic pollution control programmes. Subject index.

  16. A correspondence principle

    NASA Astrophysics Data System (ADS)

    Hughes, Barry D.; Ninham, Barry W.

    2016-02-01

    A single mathematical theme underpins disparate physical phenomena in classical, quantum and statistical mechanical contexts. This mathematical "correspondence principle", a kind of wave-particle duality with glorious realizations in classical and modern mathematical analysis, embodies fundamental geometrical and physical order, and yet in some sense sits on the edge of chaos. Illustrative cases discussed are drawn from classical and anomalous diffusion, quantum mechanics of single particles and ideal gases, quasicrystals and Casimir forces.

  17. Heisenberg's observability principle

    NASA Astrophysics Data System (ADS)

    Wolff, Johanna

    2014-02-01

    Werner Heisenberg's 1925 paper 'Quantum-theoretical re-interpretation of kinematic and mechanical relations' marks the beginning of quantum mechanics. Heisenberg famously claims that the paper is based on the idea that the new quantum mechanics should be 'founded exclusively upon relationships between quantities which in principle are observable'. My paper is an attempt to understand this observability principle, and to see whether its employment is philosophically defensible. Against interpretations of 'observability' along empiricist or positivist lines I argue that such readings are philosophically unsatisfying. Moreover, a careful comparison of Heisenberg's reinterpretation of classical kinematics with Einstein's argument against absolute simultaneity reveals that the positivist reading does not fit with Heisenberg's strategy in the paper. Instead the appeal to observability should be understood as a specific criticism of the causal inefficacy of orbital electron motion in Bohr's atomic model. I conclude that the tacit philosophical principle behind Heisenberg's argument is not a positivistic connection between observability and meaning, but the idea that a theory should not contain causally idle wheels.

  18. Introducing the Principles of Vegetation Sampling in the Laboratory.

    ERIC Educational Resources Information Center

    Williams, George J.; And Others

    1979-01-01

    Described is a sampling board that has been used in an introductory general ecology course that is inexpensive to construct and that effectively illustrates the principles of vegetation sampling. (Author/BB)

  19. Treatment of coupled fluid-structure interaction problems by a mixed variational principle

    NASA Technical Reports Server (NTRS)

    Felippa, Carlos A.; Ohayon, Roger

    1989-01-01

    A general three-field variational principle is obtained for the motion of an acoustic fluid enclosed in a rigid or flexible container by the method of canonical decomposition applied to a modified form of the wave equation in the displacement potential. The general principle is specialized to a mixed two-field principle that contains the fluid displacement potential and pressure as independent fields. Semidiscrete finite-element equations of motion based on this principle are displayed.

  20. Current fluctuations in nonequilibrium diffusive systems: an additivity principle.

    PubMed

    Bodineau, T; Derrida, B

    2004-05-01

    We formulate a simple additivity principle allowing one to calculate the whole distribution of current fluctuations through a large one dimensional system in contact with two reservoirs at unequal densities from the knowledge of its first two cumulants. This distribution (which in general is non-Gaussian) satisfies the Gallavotti-Cohen symmetry and generalizes the one predicted recently for the symmetric simple exclusion process. The additivity principle can be used to study more complex diffusive networks including loops. PMID:15169476

  1. Principles of tendon transfers.

    PubMed

    Coulet, B

    2016-04-01

    Tendon transfers are carried out to restore functional deficits by rerouting the remaining intact muscles. Transfers are highly attractive in the context of hand surgery because of the possibility of restoring the patient's ability to grip. In palsy cases, tendon transfers are only used when a neurological procedure is contraindicated or has failed. The strategy used to restore function follows a common set of principles, no matter the nature of the deficit. The first step is to clearly distinguish between deficient muscles and muscles that could be transferred. Next, the type of palsy will dictate the scope of the program and the complexity of the gripping movements that can be restored. Based on this reasoning, a surgical strategy that matches the means (transferable muscles) with the objectives (functions to restore) will be established and clearly explained to the patient. Every paralyzed hand can be described using three parameters. 1) Deficient segments: wrist, thumb and long fingers; 2) mechanical performance of muscles groups being revived: high energy-wrist extension and finger flexion that require strong transfers with long excursion; low energy-wrist flexion and finger extension movements that are less demanding mechanically, because they can be accomplished through gravity alone in some cases; 3) condition of the two primary motors in the hand: extrinsics (flexors and extensors) and intrinsics (facilitator). No matter the type of palsy, the transfer surgery follows the same technical principles: exposure, release, fixation, tensioning and rehabilitation. By performing an in-depth analysis of each case and by following strict technical principles, tendon transfer surgery leads to reproducible results; this allows the surgeon to establish clear objectives for the patient preoperatively. PMID:27117119

  2. Equivalence Principle in Cosmology

    NASA Astrophysics Data System (ADS)

    Kopeikin, Sergei

    2014-01-01

    We analyse the Einstein equivalence principle (EEP) for a Hubble observer in Friedmann-Lemaître-Robertson-Walker (FLRW) spacetime. We show that the affine structure of the light cone in the FLRW spacetime should be treated locally in terms of the optical metric gαβ which is not reduced to the Minkowski metric fαβ due to the nonuniform parametrization of the local equations of light propagation with the proper time of the observer's clock. The physical consequence of this difference is that the Doppler shift of radio waves measured locally is affected by the Hubble expansion.

  3. Talus fractures: surgical principles.

    PubMed

    Rush, Shannon M; Jennings, Meagan; Hamilton, Graham A

    2009-01-01

    Surgical treatment of talus fractures can challenge even the most skilled foot and ankle surgeon. Complicated fracture patterns combined with joint dislocation of variable degrees require accurate assessment, sound understanding of principles of fracture care, and broad command of internal fixation techniques needed for successful surgical care. Elimination of unnecessary soft tissue dissection, a low threshold for surgical reduction, liberal use of malleolar osteotomy to expose body fracture, and detailed attention to fracture reduction and joint alignment are critical to the success of treatment. Even with the best surgical care complications are common and seem to correlate with injury severity and open injuries. PMID:19121756

  4. Principles of smile design

    PubMed Central

    Bhuvaneswaran, Mohan

    2010-01-01

    An organized and systematic approach is required to evaluate, diagnose and resolve esthetic problems predictably. It is of prime importance that the final result is not dependent only on the looks alone. Our ultimate goal as clinicians is to achieve pleasing composition in the smile by creating an arrangement of various esthetic elements. This article reviews the various principles that govern the art of smile designing. The literature search was done using PubMed search and Medline. This article will provide a basic knowledge to the reader to bring out a functional stable smile. PMID:21217950

  5. Principles of smile design.

    PubMed

    Bhuvaneswaran, Mohan

    2010-10-01

    An organized and systematic approach is required to evaluate, diagnose and resolve esthetic problems predictably. It is of prime importance that the final result is not dependent only on the looks alone. Our ultimate goal as clinicians is to achieve pleasing composition in the smile by creating an arrangement of various esthetic elements. This article reviews the various principles that govern the art of smile designing. The literature search was done using PubMed search and Medline. This article will provide a basic knowledge to the reader to bring out a functional stable smile.

  6. General Dentist

    MedlinePlus

    ... to your desktop! more... What Is a General Dentist? Article Chapters What Is a General Dentist? General ... Reviewed: January 2012 ?xml:namespace> Related Articles: General Dentists FAGD and MAGD: What Do These Awards Mean? ...

  7. Chemical Principles Revisited: Perspectives on the Uncertainty Principle and Quantum Reality.

    ERIC Educational Resources Information Center

    Bartell, Lawrence S.

    1985-01-01

    Explicates an approach that not only makes the uncertainty seem more useful to introductory students but also helps convey the real meaning of the term "uncertainty." General topic areas addressed include probability amplitudes, rationale behind the uncertainty principle, applications of uncertainty relations, and quantum processes. (JN)

  8. Chemical Principles Revisited: Updating the Atomic Theory in General Chemistry.

    ERIC Educational Resources Information Center

    Whitman, Mark

    1984-01-01

    Presents a descriptive overview of recent achievements in atomic structure to provide instructors with the background necessary to enhance their classroom presentations. Topics considered include hadrons, quarks, leptons, forces, and the unified fields theory. (JN)

  9. 10 CFR 1023.3 - Principles of general applicability.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... oral) regarding any matter at issue in an appeal, nor shall any member of the Board or of the Board's... not be subject to administrative appeal or administrative review. (b) Alternative Dispute Resolution... judges limited to the nature, procedures, and availability of ADR through the Board are permitted...

  10. Symbiosis as a General Principle in Eukaryotic Evolution

    PubMed Central

    Douglas, Angela E.

    2014-01-01

    Eukaryotes have evolved and diversified in the context of persistent colonization by non-pathogenic microorganisms. Various resident microorganisms provide a metabolic capability absent from the host, resulting in increased ecological amplitude and often evolutionary diversification of the host. Some microorganisms confer primary metabolic pathways, such as photosynthesis and cellulose degradation, and others expand the repertoire of secondary metabolism, including the synthesis of toxins that confer protection against natural enemies. A further route by which microorganisms affect host fitness arises from their modulation of the eukaryotic-signaling networks that regulate growth, development, behavior, and other functions. These effects are not necessarily based on interactions beneficial to the host, but can be a consequence of either eukaryotic utilization of microbial products as cues or host–microbial conflict. By these routes, eukaryote–microbial interactions play an integral role in the function and evolutionary diversification of eukaryotes. PMID:24492707

  11. 9 CFR 381.413 - Nutrient content claims; general principles.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., except as permitted by § 381.500(d)(2). (e)(1) Because the use of a “free” or “low” claim before the name... disclaimer is required. (4) “Percent fat free” claims are not authorized by this paragraph. Such claims shall... form commonly understood to be, a breakfast, lunch, dinner, meal, or entrèe. Such representations...

  12. 9 CFR 317.313 - Nutrient content claims; general principles.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... minimum height, except as permitted by § 317.400(d)(2). (e)(1) Because the use of a “free” or “low” claim... attaches (e.g., “lard, a sodium free food”). (f) A nutrient content claim shall be in type size and style.... (4) “Percent fat free” claims are not authorized by this paragraph. Such claims shall comply...

  13. Prophylaxis of migraine: general principles and patient acceptance

    PubMed Central

    D’Amico, Domenico; Tepper, Stewart J

    2008-01-01

    Migraine is a chronic neurological condition with episodic exacerbations. Migraine is highly prevalent, and associated with significant pain, disability, and diminished quality of life. Migraine management is an important health care issue. Migraine management includes avoidance of trigger factors, lifestyle modifications, non-pharmacological therapies, and medications. Pharmacological treatment is traditionally divided into acute or symptomatic treatment, and preventive treatment or prophylaxis. Many migraine patients can be treated using only acute treatment. Patients with severe and/or frequent migraines require long-term preventive therapy. Prophylaxis requires daily administration of anti-migraine compounds with potential adverse events or contraindications, and may also interfere with other concurrent conditions and treatments. These problems may induce patients to reject the idea of a preventive treatment, leading to poor patient adherence. This paper reviews the main factors influencing patient acceptance of anti-migraine prophylaxis, providing practical suggestions to enhance patient willingness to accept pharmacological anti-migraine preventive therapy. We also provide information about the main clinical characteristics of migraine, and their negative consequences. The circumstances warranting prophylaxis in migraine patients as well as the main characteristics of the compounds currently used in migraine prophylaxis will also be briefly discussed, focusing on those aspects which can enhance patient acceptance and adherence. PMID:19337456

  14. 9 CFR 317.313 - Nutrient content claims; general principles.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... absent or present in a certain amount (e.g., “high in oat bran”); or (ii) Suggests that the product... by § 317.2(h) for the net quantity of contents statement, except where the size of the claim is less than two times the required size of the net quantity of contents statement, in which case...

  15. 9 CFR 381.413 - Nutrient content claims; general principles.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... present in a certain amount (e.g., “high in oat bran”); or (ii) Suggests that the product, because of its...) for the net quantity of contents statement, except where the size of the claim is less than two times the required size of the net quantity of contents statement, in which case the disclaimer...

  16. 9 CFR 381.413 - Nutrient content claims; general principles.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... present in a certain amount (e.g., “high in oat bran”); or (ii) Suggests that the product, because of its...) for the net quantity of contents statement, except where the size of the claim is less than two times the required size of the net quantity of contents statement, in which case the disclaimer...

  17. 9 CFR 317.313 - Nutrient content claims; general principles.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... absent or present in a certain amount (e.g., “high in oat bran”); or (ii) Suggests that the product... by § 317.2(h) for the net quantity of contents statement, except where the size of the claim is less than two times the required size of the net quantity of contents statement, in which case...

  18. 9 CFR 317.313 - Nutrient content claims; general principles.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... absent or present in a certain amount (e.g., “high in oat bran”); or (ii) Suggests that the product... by § 317.2(h) for the net quantity of contents statement, except where the size of the claim is less than two times the required size of the net quantity of contents statement, in which case...

  19. 9 CFR 381.413 - Nutrient content claims; general principles.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... present in a certain amount (e.g., “high in oat bran”); or (ii) Suggests that the product, because of its...) for the net quantity of contents statement, except where the size of the claim is less than two times the required size of the net quantity of contents statement, in which case the disclaimer...

  20. 23 CFR 627.5 - General principles and procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... studies. (2) Studies. Value engineering studies shall follow the widely recognized systematic problem-solving analysis process that is used throughout private industry and governmental agencies. Studies must be performed using multi-disciplined teams of individuals not personally involved in the design...

  1. 10 CFR 1023.3 - Principles of general applicability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the record established in each case. Written or oral communication with the Board by or for one party... oral) regarding any matter at issue in an appeal, nor shall any member of the Board or of the...

  2. Generalized Maximum Entropy Principle, Superstatistics and Problem of Networks Classification

    NASA Astrophysics Data System (ADS)

    Gadjiev, Bahruz

    2011-03-01

    In the presented paper the results of superstatistics methods are given to study growing networks with exponential topology. Topologies of strongly inhomogeneous growing networks are determined. In the framework of maximum entropy method the probability distribution of real networks is derived and their classification is discussed.

  3. General principles of single-construct chromosomal gene drive.

    PubMed

    Marshall, John M; Hay, Bruce A

    2012-07-01

    Gene drive systems are genetic elements capable of spreading into a population even if they confer a fitness cost to their host. We consider a class of drive systems consisting of a chromosomally located, linked cluster of genes, the presence of which renders specific classes of offspring arising from specific parental crosses unviable. Under permissive conditions, a number of these elements are capable of distorting the offspring ratio in their favor. We use a population genetic framework to derive conditions under which these elements spread to fixation in a population or induce a population crash. Many of these systems can be engineered using combinations of toxin and antidote genes, analogous to Medea, which consists of a maternal toxin and zygotic antidote. The majority of toxin-antidote drive systems require a critical frequency to be exceeded before they spread into a population. Of particular interest, a Z-linked Medea construct with a recessive antidote is expected to induce an all-male population crash for release frequencies above 50%. We suggest molecular tools that may be used to build these systems, and discuss their relevance to the control of a variety of insect pest species, including mosquito vectors of diseases such as malaria and dengue fever.

  4. 9 CFR 317.313 - Nutrient content claims; general principles.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... formulas and medical foods, as described in 21 CFR 101.13(q)(4). (5) (6) Nutrient content claims that were... product, e.g., “low sodium” or “contains 100 calories.” (2) An implied nutrient content claim is any claim... misleading in any respect (e.g., “100 calories” or “5 grams of fat”), in which case no disclaimer is...

  5. 9 CFR 381.413 - Nutrient content claims; general principles.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... formulas and medical foods, as described in 21 CFR 101.13(q)(4). (5) (6) Nutrient content claims that were... sodium” or “contains 100 calories.” (2) An implied nutrient content claim is any claim that: (i... false or misleading in any respect (e.g., “100 calories” or “5 grams of fat”), in which case...

  6. 2 CFR Appendix A to Part 230 - General Principles

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... income (i.e., gross income earned from federally-supported activities) see § 215.24 of 2 CFR part 215... but the allocability of costs provisions of Appendix A, subsection C.e. of 2 CFR part 225 (OMB Circular A-87); Appendix A, Section C.4. of 2 CFR part 220 (OMB Circular A-21); Section A.4. of...

  7. 2 CFR Appendix A to Part 230 - General Principles

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... income (i.e., gross income earned from federally-supported activities) see § 215.24 of 2 CFR part 215... but the allocability of costs provisions of Appendix A, subsection C.e. of 2 CFR part 225 (OMB Circular A-87); Appendix A, Section C.4. of 2 CFR part 220 (OMB Circular A-21); Section A.4. of...

  8. 2 CFR Appendix A to Part 230 - General Principles

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CFR part 215 Uniform Administrative Requirements for Grants and Agreements with Institutions of Higher... but the allocability of costs provisions of Appendix A, subsection C.e. of 2 CFR part 225 (OMB Circular A-87); Appendix A, Section C.4. of 2 CFR part 220 (OMB Circular A-21); Section A.4. of...

  9. 2 CFR Appendix A to Part 230 - General Principles

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... income (i.e., gross income earned from federally-supported activities) see § 215.24 of 2 CFR part 215... but the allocability of costs provisions of Appendix A, subsection C.e. of 2 CFR part 225 (OMB Circular A-87); Appendix A, Section C.4. of 2 CFR part 220 (OMB Circular A-21); Section A.4. of...

  10. Working with laboratory animals: general principles and practical considerations.

    PubMed

    Wright, K C

    1997-01-01

    Laboratory animals play an indispensable role in research discovery and technological advances, and they will continue to yield basic, exciting, and prodigious information that can enrich the future of people and other animals. For both ethical and scientific reasons, all-individuals whose work requires the use of laboratory animals must take the time to conduct a thorough review of the literature to determine what animal models are available and which are the most relevant, and they must learn and understand the uniqueness of the selected species, breed, and strain. Scientists have the privilege, but not the right, to use animals as experimental subjects. This privilege must not be abused. Therefore, it is imperative that before working with any laboratory animal, you know your "subject." PMID:9152909

  11. Symbiosis as a general principle in eukaryotic evolution.

    PubMed

    Douglas, Angela E

    2014-02-01

    Eukaryotes have evolved and diversified in the context of persistent colonization by non-pathogenic microorganisms. Various resident microorganisms provide a metabolic capability absent from the host, resulting in increased ecological amplitude and often evolutionary diversification of the host. Some microorganisms confer primary metabolic pathways, such as photosynthesis and cellulose degradation, and others expand the repertoire of secondary metabolism, including the synthesis of toxins that confer protection against natural enemies. A further route by which microorganisms affect host fitness arises from their modulation of the eukaryotic-signaling networks that regulate growth, development, behavior, and other functions. These effects are not necessarily based on interactions beneficial to the host, but can be a consequence of either eukaryotic utilization of microbial products as cues or host-microbial conflict. By these routes, eukaryote-microbial interactions play an integral role in the function and evolutionary diversification of eukaryotes.

  12. In vivo confocal imaging: general principles and applications.

    PubMed

    Petroll, W M; Jester, J V; Cavanagh, H D

    1994-01-01

    It is well established that confocal microscopy provides higher resolution images with better rejection of out-of-focus information than conventional light microscopy. The optical sectioning ability of confocal microscopy allows images to be obtained from different depths within a thick tissue specimen, thereby eliminating the need for processing and sectioning procedures. Thus, confocal microscopy has made it possible to view biological tissues under more physiologic conditions than previously possible. The most widespread biological application of confocal microscopy has been in the localization of immunofluorescently labeled proteins in cell culture or within excised blocks of tissue. Because of its noninvasive optical sectioning capability, confocal microscopy is also ideally suited to the study of tissue in intact living animals, although the potential in vivo applications of this paradigm have received less attention. In this paper we trace the development of in vivo confocal microscopy and present examples of current capabilities for both research and clinical use.

  13. Generalized uncertainty principle and self-adjoint operators

    SciTech Connect

    Balasubramanian, Venkat; Das, Saurya; Vagenas, Elias C.

    2015-09-15

    In this work we explore the self-adjointness of the GUP-modified momentum and Hamiltonian operators over different domains. In particular, we utilize the theorem by von-Neumann for symmetric operators in order to determine whether the momentum and Hamiltonian operators are self-adjoint or not, or they have self-adjoint extensions over the given domain. In addition, a simple example of the Hamiltonian operator describing a particle in a box is given. The solutions of the boundary conditions that describe the self-adjoint extensions of the specific Hamiltonian operator are obtained.

  14. 23 CFR 627.5 - General principles and procedures.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... project meeting the project criteria in 23 CFR 627.1(a), the STDs shall fulfill the value engineering...) and (b), 302, 315; and 49 CFR part 18. § 627.1 Purpose and applicability. (a) The purpose of this part... bridge. Final design. Final design has the same meaning as defined in 23 CFR 636.103. Project. A...

  15. Principle or constructive relativity

    NASA Astrophysics Data System (ADS)

    Frisch, Mathias

    Appealing to Albert Einstein's distinction between principle and constructive theories, Harvey Brown has argued for an interpretation of the theory of relativity as a dynamic and constructive theory. Brown's view has been challenged by Michel Janssen and in this paper I investigate their dispute. I argue that their disagreement appears larger than it actually is due to the two frameworks used by Brown and Janssen to express their respective views: Brown's appeal to Einstein's principle-constructive distinction and Janssen's framing of the disagreement as one over the question whether relativity provides a kinematic or a dynamic constraint. I appeal to a distinction between types of theories drawn by H. A. Lorentz two decades before Einstein's distinction to argue that Einstein's distinction represents a false dichotomy. I argue further that the disagreement concerning the kinematics-dynamics distinction is a disagreement about labels but not about substance. There remains a genuine disagreement over the explanatory role of spacetime geometry and here I agree with Brown arguing that Janssen sees a pressing need for an explanation of Lorentz invariance where no further explanation is needed.

  16. Principle of relative locality

    SciTech Connect

    Amelino-Camelia, Giovanni; Freidel, Laurent; Smolin, Lee; Kowalski-Glikman, Jerzy

    2011-10-15

    We propose a deepening of the relativity principle according to which the invariant arena for nonquantum physics is a phase space rather than spacetime. Descriptions of particles propagating and interacting in spacetimes are constructed by observers, but different observers, separated from each other by translations, construct different spacetime projections from the invariant phase space. Nonetheless, all observers agree that interactions are local in the spacetime coordinates constructed by observers local to them. This framework, in which absolute locality is replaced by relative locality, results from deforming energy-momentum space, just as the passage from absolute to relative simultaneity results from deforming the linear addition of velocities. Different aspects of energy-momentum space geometry, such as its curvature, torsion and nonmetricity, are reflected in different kinds of deformations of the energy-momentum conservation laws. These are in principle all measurable by appropriate experiments. We also discuss a natural set of physical hypotheses which singles out the cases of energy-momentum space with a metric compatible connection and constant curvature.

  17. An uncertainty principle for unimodular quantum groups

    SciTech Connect

    Crann, Jason; Kalantar, Mehrdad E-mail: mkalanta@math.carleton.ca

    2014-08-15

    We present a generalization of Hirschman's entropic uncertainty principle for locally compact Abelian groups to unimodular locally compact quantum groups. As a corollary, we strengthen a well-known uncertainty principle for compact groups, and generalize the relation to compact quantum groups of Kac type. We also establish the complementarity of finite-dimensional quantum group algebras. In the non-unimodular setting, we obtain an uncertainty relation for arbitrary locally compact groups using the relative entropy with respect to the Haar weight as the measure of uncertainty. We also show that when restricted to q-traces of discrete quantum groups, the relative entropy with respect to the Haar weight reduces to the canonical entropy of the random walk generated by the state.

  18. The Aristotelian definition of motion and the principle of inertia

    NASA Astrophysics Data System (ADS)

    McLaughlin, Thomas J.

    2001-07-01

    This dissertation argues that Newton's First Law of Motion, also known as the principle of inertia, is compatible with the Aristotelian definition of motion accepted by St. Thomas Aquinas and with the mover causality principle, which follows from that definition. The argument distinguishes Aquinas' general principles of natural philosophy from his more specific principles of nature. Thus, one can abandon Aquinas' geocentric cosmology without rejecting his entire philosophy of nature, which includes principles such as the four causes, the mover causality principle, and the definitions of motion and time. That is, the Aristotelian conception of what motion is as such does not depend upon Aquinas' accounts of gravitational, projectile, and celestial motion. After explaining what Aquinas means by the definition of motion, "the act of a being in potency insofar as it is in potency," I argue that Aquinas' view of the mover causality principle, "whatever is moved is moved by another," has been frequently misunderstood. Aquinas did not hold that the mover causality principle requires a continuously acting mover to sustain a body's motion. I then show, using Newton's examples of the First Law of Motion, his conception of inertia, the common practice of physicists and astronomers, and other arguments, that the principle of inertia requires a version of the mover causality principle that is compatible with Aquinas' own understanding. I then argue that the principle of inertia is distinct from the philosophical framework within which it has been commonly and historically conceived. In this framework, motion is no longer thought of as a coming to be but is considered a first principle or an unchanging primary quality, a view that the principle of inertia seemingly instantiates through the notion of a "state." This philosophical framework distorts the understanding of the principle of inertia. I argue that the principle of inertia is more intelligibly understood in light of the

  19. Principles of vestibular pharmacotherapy.

    PubMed

    Chabbert, C

    2016-01-01

    Ideally, vestibular pharmacotherapy is intended, through specific and targeted molecular actions, to significantly alleviate vertigo symptoms, to protect or repair the vestibular sensory network under pathologic conditions, and to promote vestibular compensation, with the eventual aim of improving the patient's quality of life. In fact, in order to achieve this aim, considerable progress still needs to be made. The lack of information on the etiology of vestibular disorders and the pharmacologic targets to modulate, as well as the technical challenge of targeting a drug to its effective site are some of the main issues yet to be overcome. In this review, my intention is to provide an account of the therapeutic principles that have shaped current vestibular pharmacotherapy and to further explore crucial questions that must be taken into consideration in order to develop targeted and specific pharmacologic therapies for each type and stage of vestibular disorders. PMID:27638072

  20. System level electrochemical principles

    NASA Technical Reports Server (NTRS)

    Thaller, L. H.

    1985-01-01

    The traditional electrochemical storage concepts are difficult to translate into high power, high voltage multikilowatt storage systems. The increased use of electronics, and the use of electrochemical couples that minimize the difficulties associated with the corrective measures to reduce the cell to cell capacity dispersion were adopted by battery technology. Actively cooled bipolar concepts are described which represent some attractive alternative system concepts. They are projected to have higher energy densities lower volumes than current concepts. They should be easier to scale from one capacity to another and have a closer cell to cell capacity balance. These newer storage system concepts are easier to manage since they are designed to be a fully integrated battery. These ideas are referred to as system level electrochemistry. The hydrogen-oxygen regenerative fuel cells (RFC) is probably the best example of the integrated use of these principles.

  1. Neuronavigation. Principles. Surgical technique.

    PubMed

    Ivanov, Marcel; Ciurea, Alexandru Vlad

    2009-01-01

    Neuronavigation and stereotaxy are techniques designed to help neurosurgeons precisely localize different intracerebral pathological processes by using a set of preoperative images (CT, MRI, fMRI, PET, SPECT etc.). The development of computer assisted surgery was possible only after a significant technological progress, especially in the area of informatics and imagistics. The main indications of neuronavigation are represented by the targeting of small and deep intracerebral lesions and choosing the best way to treat them, in order to preserve the neurological function. Stereotaxis also allows lesioning or stimulation of basal ganglia for the treatment of movement disorders. These techniques can bring an important amount of confort both to the patient and to the neurosurgeon. Neuronavigation was introduced in Romania around 2003, in four neurosurgical centers. We present our five-years experience in neuronavigation and describe the main principles and surgical techniques.

  2. Neuronavigation. Principles. Surgical technique.

    PubMed

    Ivanov, Marcel; Ciurea, Alexandru Vlad

    2009-01-01

    Neuronavigation and stereotaxy are techniques designed to help neurosurgeons precisely localize different intracerebral pathological processes by using a set of preoperative images (CT, MRI, fMRI, PET, SPECT etc.). The development of computer assisted surgery was possible only after a significant technological progress, especially in the area of informatics and imagistics. The main indications of neuronavigation are represented by the targeting of small and deep intracerebral lesions and choosing the best way to treat them, in order to preserve the neurological function. Stereotaxis also allows lesioning or stimulation of basal ganglia for the treatment of movement disorders. These techniques can bring an important amount of confort both to the patient and to the neurosurgeon. Neuronavigation was introduced in Romania around 2003, in four neurosurgical centers. We present our five-years experience in neuronavigation and describe the main principles and surgical techniques. PMID:20108488

  3. Dynamical principles in neuroscience

    SciTech Connect

    Rabinovich, Mikhail I.; Varona, Pablo; Selverston, Allen I.; Abarbanel, Henry D. I.

    2006-10-15

    Dynamical modeling of neural systems and brain functions has a history of success over the last half century. This includes, for example, the explanation and prediction of some features of neural rhythmic behaviors. Many interesting dynamical models of learning and memory based on physiological experiments have been suggested over the last two decades. Dynamical models even of consciousness now exist. Usually these models and results are based on traditional approaches and paradigms of nonlinear dynamics including dynamical chaos. Neural systems are, however, an unusual subject for nonlinear dynamics for several reasons: (i) Even the simplest neural network, with only a few neurons and synaptic connections, has an enormous number of variables and control parameters. These make neural systems adaptive and flexible, and are critical to their biological function. (ii) In contrast to traditional physical systems described by well-known basic principles, first principles governing the dynamics of neural systems are unknown. (iii) Many different neural systems exhibit similar dynamics despite having different architectures and different levels of complexity. (iv) The network architecture and connection strengths are usually not known in detail and therefore the dynamical analysis must, in some sense, be probabilistic. (v) Since nervous systems are able to organize behavior based on sensory inputs, the dynamical modeling of these systems has to explain the transformation of temporal information into combinatorial or combinatorial-temporal codes, and vice versa, for memory and recognition. In this review these problems are discussed in the context of addressing the stimulating questions: What can neuroscience learn from nonlinear dynamics, and what can nonlinear dynamics learn from neuroscience?.

  4. Fault Management Guiding Principles

    NASA Technical Reports Server (NTRS)

    Newhouse, Marilyn E.; Friberg, Kenneth H.; Fesq, Lorraine; Barley, Bryan

    2011-01-01

    Regardless of the mission type: deep space or low Earth orbit, robotic or human spaceflight, Fault Management (FM) is a critical aspect of NASA space missions. As the complexity of space missions grows, the complexity of supporting FM systems increase in turn. Data on recent NASA missions show that development of FM capabilities is a common driver for significant cost overruns late in the project development cycle. Efforts to understand the drivers behind these cost overruns, spearheaded by NASA's Science Mission Directorate (SMD), indicate that they are primarily caused by the growing complexity of FM systems and the lack of maturity of FM as an engineering discipline. NASA can and does develop FM systems that effectively protect mission functionality and assets. The cost growth results from a lack of FM planning and emphasis by project management, as well the maturity of FM as an engineering discipline, which lags behind the maturity of other engineering disciplines. As a step towards controlling the cost growth associated with FM development, SMD has commissioned a multi-institution team to develop a practitioner's handbook representing best practices for the end-to-end processes involved in engineering FM systems. While currently concentrating primarily on FM for science missions, the expectation is that this handbook will grow into a NASA-wide handbook, serving as a companion to the NASA Systems Engineering Handbook. This paper presents a snapshot of the principles that have been identified to guide FM development from cradle to grave. The principles range from considerations for integrating FM into the project and SE organizational structure, the relationship between FM designs and mission risk, and the use of the various tools of FM (e.g., redundancy) to meet the FM goal of protecting mission functionality and assets.

  5. Generalized Communities in Networks

    NASA Astrophysics Data System (ADS)

    Newman, M. E. J.; Peixoto, Tiago P.

    2015-08-01

    A substantial volume of research is devoted to studies of community structure in networks, but communities are not the only possible form of large-scale network structure. Here, we describe a broad extension of community structure that encompasses traditional communities but includes a wide range of generalized structural patterns as well. We describe a principled method for detecting this generalized structure in empirical network data and demonstrate with real-world examples how it can be used to learn new things about the shape and meaning of networks.

  6. [The precautionary principle: advantages and risks].

    PubMed

    Tubiana, M

    2001-04-01

    The extension of the precautionary principle to the field of healthcare is the social response to two demands of the population: improved health safety and the inclusion of an informed public in the decision-making process. The necessary balance between cost (treatment-induced risk) and benefit (therapeutic effect) underlies all healthcare decisions. An underestimation or an overestimation of cost, i.e. risk, is equally harmful in public healthcare. A vaccination should be prescribed when its beneficial effect outweighs its inevitable risk. Mandatory vaccination, such as in the case of the Hepatitis B virus, is a health policy requiring some courage because those who benefit will never be aware of its positive effect while those who are victims of the risk could resort to litigation. Defense against such accusations requires an accurate assessment of risk and benefit, which underlines the importance of expertise. Even within the framework of the precautionary principle, it is impossible to act without knowledge, or at least a plausible estimation, of expected effects. Recent affairs (blood contamination, transmissible spongiform encephalitis by growth hormone, and new variant of Creutzfeldt-Jacob disease) illustrate that in such cases the precautionary principle would have had limited impact and it is only when enough knowledge was available that effective action could be taken. Likewise, in current debates concerning the possible risks of electromagnetic fields, cellular phones and radon, research efforts must be given priority. The general public understands intuitively the concept of cost and benefit. For example, the possible health risks of oral contraceptives and hormone replacement therapy were not ignored, but the public has judged that their advantages justify the risk. Estimating risk and benefit and finding a balance between risk and preventive measures could help avoid the main drawbacks of the precautionary principle, i.e. inaction and refusal of

  7. Principles of Naval Engineering.

    ERIC Educational Resources Information Center

    Naval Personnel Program Support Activity, Washington, DC.

    Fundamentals of shipboard machinery, equipment, and engineering plants are presented in this text prepared for engineering officers. A general description is included of the development of naval ships, ship design and construction, stability and buoyancy, and damage and casualty control. Engineering theories are explained on the background of ship…

  8. Energy conservation principles

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This paper and presentation discuss preliminary findings from energy audits conducted in cotton gins in six states including the allocation of motor horse power and kilowatt hours energy consumption per bale. General inferences will be drawn from information collected at gin plants of various bale...

  9. Principles of effective performance measurement

    SciTech Connect

    Stevens, D.F.

    1996-07-01

    As with any endeavor connected with trendy words and phrases, {open_quotes}performance measurement{close_quotes} means different things to different people. To some, performance means {open_quotes}customer satisfaction{close_quotes}, and little, if anything, else. To others, it is productivity; to still others, it is procedural. In most real-world situations there are elements of all three of these dimensions. Whatever your definition of performance, it is important that it be clear in your own mind what you are trying to achieve, and that you make sure that those working with and for you have the same understanding. This paper is written from the point of view that performance is primarily productivity; after acceptable productivity is achieved, performance is customer satisfaction. I consider performance to be procedural only insofar as necessary to maintain legality and propriety. Rather than adopting the standard bureaucratic approach to procedure (i.e., everything not required is forbidden), I believe that consistently excellent performance demands the complementary philosophy: everything not forbidden is permitted. Remember: wars are won by the general who knows when to break the rules. The principles enunciated below are not unique to DOE or to the office environment: They are applicable to any performance measurement program. I have tried, however, to provide examples that apply to the office or that are likely to be familiar to those of us working with office information technology today.

  10. Design principles for riboswitch function.

    PubMed

    Beisel, Chase L; Smolke, Christina D

    2009-04-01

    Scientific and technological advances that enable the tuning of integrated regulatory components to match network and system requirements are critical to reliably control the function of biological systems. RNA provides a promising building block for the construction of tunable regulatory components based on its rich regulatory capacity and our current understanding of the sequence-function relationship. One prominent example of RNA-based regulatory components is riboswitches, genetic elements that mediate ligand control of gene expression through diverse regulatory mechanisms. While characterization of natural and synthetic riboswitches has revealed that riboswitch function can be modulated through sequence alteration, no quantitative frameworks exist to investigate or guide riboswitch tuning. Here, we combined mathematical modeling and experimental approaches to investigate the relationship between riboswitch function and performance. Model results demonstrated that the competition between reversible and irreversible rate constants dictates performance for different regulatory mechanisms. We also found that practical system restrictions, such as an upper limit on ligand concentration, can significantly alter the requirements for riboswitch performance, necessitating alternative tuning strategies. Previous experimental data for natural and synthetic riboswitches as well as experiments conducted in this work support model predictions. From our results, we developed a set of general design principles for synthetic riboswitches. Our results also provide a foundation from which to investigate how natural riboswitches are tuned to meet systems-level regulatory demands. PMID:19381267

  11. Design principles underlying circadian clocks.

    PubMed Central

    Rand, D. A.; Shulgin, B. V.; Salazar, D.; Millar, A. J.

    2004-01-01

    A fundamental problem for regulatory networks is to understand the relation between form and function: to uncover the underlying design principles of the network. Circadian clocks present a particularly interesting instance, as recent work has shown that they have complex structures involving multiple interconnected feedback loops with both positive and negative feedback. While several authors have speculated on the reasons for this, a convincing explanation is still lacking.We analyse both the flexibility of clock networks and the relationships between various desirable properties such as robust entrainment, temperature compensation, and stability to environmental variations and parameter fluctuations. We use this to argue that the complexity provides the flexibility necessary to simultaneously attain multiple key properties of circadian clocks. As part of our analysis we show how to quantify the key evolutionary aims using infinitesimal response curves, a tool that we believe will be of general utility in the analysis of regulatory networks. Our results suggest that regulatory and signalling networks might be much less flexible and of lower dimension than their apparent complexity would suggest. PMID:16849158

  12. What is the outcome of applying principlism?

    PubMed

    Hine, Kristen

    2011-12-01

    The four principles approach to bioethics, an approach most associated with the work of Tom Beauchamp and James Childress, is supposed to provide a framework for reasoning through moral issues in medicine. One might wonder, if one were to guide one's thinking by the method suggested by principlism, will one identify and perform the objectively morally right action? Will one's decision making be justified, and consequently, will the action that flows from that decision itself be justified? In this paper, I show that principlism can, and has been, characterized in these two different ways. I also argue that when it is understood according to the first characterization, the view cannot be put into practice. However, when it is understood as an account of justification, there is reason to think that it is indeed action-guiding. Given the problems that confront the first version of the view, perhaps it is best to understand principlism, and biomedical ethical theories generally, not as action-guiding theories of right action, but rather, as procedures by which one's decisions and actions in medicine can achieve a reasonable degree of moral justification.

  13. Bateman's principle and immunity.

    PubMed Central

    Rolff, Jens

    2002-01-01

    The immunocompetence handicap hypothesis (ICHH) of Folstad and Karter has inspired a large number of studies that have tried to understand the causal basis of parasite-mediated sexual selection. Even though this hypothesis is based on the double function of testosterone, a hormone restricted to vertebrates, studies of invertebrates have tended to provide central support for specific predictions of the ICHH. I propose an alternative hypothesis that explains many of the findings without relying on testosterone or other biochemical feedback loops. This alternative is based on Bateman's principle, that males gain fitness by increasing their mating success whilst females increase fitness through longevity because their reproductive effort is much higher. Consequently, I predict that females should invest more in immunity than males. The extent of this dimorphism is determined by the mating system and the genetic correlation between males and females in immune traits. In support of my arguments, I mainly use studies on insects that share innate immunity with vertebrates and have the advantage that they are easier to study. PMID:11958720

  14. Principles of alternative gerontology

    PubMed Central

    Bilinski, Tomasz; Bylak, Aneta; Zadrag-Tecza, Renata

    2016-01-01

    Surveys of taxonomic groups of animals have shown that contrary to the opinion of most gerontologists aging is not a genuine trait. The process of aging is not universal and its mechanisms have not been widely conserved among species. All life forms are subject to extrinsic and intrinsic destructive forces. Destructive effects of stochastic events are visible only when allowed by the specific life program of an organism. Effective life programs of immortality and high longevity eliminate the impact of unavoidable damage. Organisms that are capable of agametic reproduction are biologically immortal. Mortality of an organism is clearly associated with terminal specialisation in sexual reproduction. The longevity phenotype that is not accompanied by symptoms of senescence has been observed in those groups of animals that continue to increase their body size after reaching sexual maturity. This is the result of enormous regeneration abilities of both of the above-mentioned groups. Senescence is observed when: (i) an organism by principle switches off the expression of existing growth and regeneration programs, as in the case of imago formation in insect development; (ii) particular programs of growth and regeneration of progenitors are irreversibly lost, either partially or in their entirety, in mammals and birds. “We can't solve problems by using the same kind of thinking we used when we created them.” (Ascribed to Albert Einstein) PMID:27017907

  15. Great Lakes Literacy Principles

    NASA Astrophysics Data System (ADS)

    Fortner, Rosanne W.; Manzo, Lyndsey

    2011-03-01

    Lakes Superior, Huron, Michigan, Ontario, and Erie together form North America's Great Lakes, a region that contains 20% of the world's fresh surface water and is home to roughly one quarter of the U.S. population (Figure 1). Supporting a $4 billion sport fishing industry, plus $16 billion annually in boating, 1.5 million U.S. jobs, and $62 billion in annual wages directly, the Great Lakes form the backbone of a regional economy that is vital to the United States as a whole (see http://www.miseagrant.umich.edu/downloads/economy/11-708-Great-Lakes-Jobs.pdf). Yet the grandeur and importance of this freshwater resource are little understood, not only by people in the rest of the country but also by many in the region itself. To help address this lack of knowledge, the Centers for Ocean Sciences Education Excellence (COSEE) Great Lakes, supported by the U.S. National Science Foundation and the National Oceanic and Atmospheric Administration, developed literacy principles for the Great Lakes to serve as a guide for education of students and the public. These “Great Lakes Literacy Principles” represent an understanding of the Great Lakes' influences on society and society's influences on the Great Lakes.

  16. Principles of alternative gerontology.

    PubMed

    Bilinski, Tomasz; Bylak, Aneta; Zadrag-Tecza, Renata

    2016-04-01

    Surveys of taxonomic groups of animals have shown that contrary to the opinion of most gerontologists aging is not a genuine trait. The process of aging is not universal and its mechanisms have not been widely conserved among species. All life forms are subject to extrinsic and intrinsic destructive forces. Destructive effects of stochastic events are visible only when allowed by the specific life program of an organism. Effective life programs of immortality and high longevity eliminate the impact of unavoidable damage. Organisms that are capable of agametic reproduction are biologically immortal. Mortality of an organism is clearly associated with terminal specialisation in sexual reproduction. The longevity phenotype that is not accompanied by symptoms of senescence has been observed in those groups of animals that continue to increase their body size after reaching sexual maturity. This is the result of enormous regeneration abilities of both of the above-mentioned groups. Senescence is observed when: (i) an organism by principle switches off the expression of existing growth and regeneration programs, as in the case of imago formation in insect development; (ii) particular programs of growth and regeneration of progenitors are irreversibly lost, either partially or in their entirety, in mammals and birds. PMID:27017907

  17. Principles of electroanatomic mapping.

    PubMed

    Bhakta, Deepak; Miller, John M

    2008-01-01

    Electrophysiologic testing and radiofrequency ablation have evolved as curative measures for a variety of rhythm disturbances. As experience in this field has grown, ablation is progressively being used to address more complex rhythm disturbances. Paralleling this trend are technological advancements to facilitate these efforts, including electroanatomic mapping (EAM). At present, several different EAM systems utilizing various technologies are available to facilitate mapping and ablation. Use of these systems has been shown to reduce fluoroscopic exposure and radiation dose, with less significant effects on procedural duration and success rates. Among the data provided by EAM are chamber reconstruction, tagging of important anatomic landmarks and ablation lesions, display of diagnostic and mapping catheters without using fluoroscopy, activation mapping, and voltage (or scar) mapping. Several EAM systems have specialized features, such as enhanced ability to map non-sustained or hemodynamically unstable arrhythmias, ability to display diagnostic as well as mapping catheter positions, and wide compatibility with a variety of catheters. Each EAM system has its strengths and weaknesses, and the system chosen must depend upon what data is required for procedural success (activation mapping, substrate mapping, cardiac geometry), the anticipated arrhythmia, the compatibility of the system with adjunctive tools (i.e. diagnostic and ablation catheters), and the operator's familiarity with the selected system. While EAM can offer significant assistance during an EP procedure, their incorrect or inappropriate application can substantially hamper mapping efforts and procedural success, and should not replace careful interpretation of data and strict adherence to electrophysiologic principles.

  18. Principles and the Development of Physical Theory: Case Studies

    NASA Astrophysics Data System (ADS)

    Hovis, Robert Corby

    Three separate articles make up the chapters of this dissertation. They were written with different aims and audiences in mind, but each deals in some way with one or more "principles" that have been invoked in argumentation and explanation in the physical sciences. The principles of concern are propositions which have an "aesthetic" or "foundational" or "philosophical" character and which are (or have been) generally believed to be widely applicable or particularly powerful--for example, the Principle of Plenitude, the Principle of Mathematical Beauty, Occam's Razor, the Cosmological Principle, and the Copernican Principle. Chapter 1 provides an overview of the nature and uses of principles in scientific reasoning and examines in some detail the use of the Principle of Plenitude in the introduction of "tachyons" (faster-than-light particles) into theoretical physics during the 1960s. Chapter 2 is a short biography of P. A. M. Dirac (1902-1984), one of the founders of quantum mechanics, who believed that the Principle of Mathematical Beauty should serve as physicists' guide to truth. Chapter 3 traces the history of the idea of faster-than-light particles in physics since the late 1800s; this idea matured with the rise of the subfield of tachyon physics in the 1960s, and (as mentioned above) physicists appealed to the Principle of Plenitude to argue for the existence of the particles, which are still only hypothetical. According to the thesis developed in these chapters, the epistemological status of principles has evolved over the history of science. While they were once hallowed as a priori truths, in modern science they have increasingly been employed critically, in light of the results of scientific inquiry. That is, science has moved toward making principles testable, subject to rejection or revision, on a par with other scientific propositions.

  19. [The beginning of the first principles: the anthropic principle].

    PubMed

    González de Posada, Francisco

    2004-01-01

    The nowadays classical Anthropic Principle is put both in the historical perspective of the traditional problem of "the place of man in the Universe', and in the confluence of several scientific "border" issues, some of which, due to their problematical nature, are also subject of philosophical analysis. On the one hand, the scientific uses of the Principle, related to the initial and constitutional conditions of "our Universe", are enumerated, as they are supposedly necessary for the appearance and consequent development of Life--up to Man--. On the other, an organized collection of the principles of today's Physics is synthetically exhibited. The object of this work is to determine the intrinsic scientific nature of the Anthropic Principle, and the role it plays in the global frame of the principles of Physics (Astrophysics, Astrobiology and Cosmology).

  20. Non-differentiable variational principles

    NASA Astrophysics Data System (ADS)

    Cresson, Jacky

    2005-07-01

    We develop a calculus of variations for functionals which are defined on a set of non-differentiable curves. We first extend the classical differential calculus in a quantum calculus, which allows us to define a complex operator, called the scale derivative, which is the non-differentiable analogue of the classical derivative. We then define the notion of extremals for our functionals and obtain a characterization in term of a generalized Euler-Lagrange equation. We finally prove that solutions of the Schrödinger equation can be obtained as extremals of a non-differentiable variational principle, leading to an extended Hamilton's principle of least action for quantum mechanics. We compare this approach with the scale relativity theory of Nottale, which assumes a fractal structure of space-time.Résumé (Principes variationnels non différentiable). Nous développons un calcul des variations pour des fonctionnelles définies sur un ensemble de courbes non différentiables. Pour cela, nous étendons le calcul différentiel classique, en calcul appelé calcul quantique, qui nous permet de définir un opérateur à valeur complexes, appelé dérivée d'échelle, qui est l'analogue non différentiable de la dérivée usuelle. On définit alors la notion d'extremale pour ces fonctionnelles pour lesquelles nous obtenons une caractérisation via une équation d'Euler-Lagrange généralisée. On prouve enfin que les solutions de l'équation de Schrödinger peuvent s'obtenir comme solution d'un problème variationnel non différentiable, étendant ainsi le principe de moindre action de Hamilton au cadre de la mécanique quantique. On discute enfin la connexion entre ce travail et la théorie de la relativité d'échelle développée par Nottale, et qui suppose une structure fractale de l'espace-temps.

  1. Principles of ecosystem sustainability

    SciTech Connect

    Chapin, F.S. III; Torn, M.S.; Tateno, Masaki

    1996-12-01

    Many natural ecosystems are self-sustaining, maintaining an characteristic mosaic of vegetation types of hundreds to thousands of years. In this article we present a new framework for defining the conditions that sustain natural ecosystems and apply these principles to sustainability of managed ecosystems. A sustainable ecosystem is one that, over the normal cycle of disturbance events, maintains its characteristics diversity of major functional groups, productivity, and rates of biogeochemical cycling. These traits are determined by a set of four {open_quotes}interactive controls{close_quotes} (climate, soil resource supply, major functional groups of organisms, and disturbance regime) that both govern and respond to ecosystem processes. Ecosystems cannot be sustained unless the interactive controls oscillate within stable bounds. This occurs when negative feedbacks constrain changes in these controls. For example, negative feedbacks associated with food availability and predation often constrain changes in the population size of a species. Linkages among ecosystems in a landscape can contribute to sustainability by creating or extending the feedback network beyond a single patch. The sustainability of managed systems can be increased by maintaining interactive controls so that they form negative feedbacks within ecosystems and by using laws and regulations to create negative feedbacks between ecosystems and human activities, such as between ocean ecosystems and marine fisheries. Degraded ecosystems can be restored through practices that enhance positive feedbacks to bring the ecosystem to a state where the interactive controls are commensurate with desired ecosystem characteristics. The possible combinations of interactive controls that govern ecosystem traits are limited by the environment, constraining the extent to which ecosystems can be managed sustainably for human purposes. 111 refs., 3 figs., 2 tabs.

  2. Principles of Vaccination.

    PubMed

    Zepp, Fred

    2016-01-01

    immunotherapies to tackle diseases such as cancer, Alzheimer's disease, and autoimmune disease. This chapter gives an overview of the key considerations and processes involved in vaccine development. It also describes the basic principles of normal immune respoinses and its their function in defense of infectious agents by vaccination.

  3. Hydrotectonics; principles and relevance

    USGS Publications Warehouse

    Kopf, R.W.

    1982-01-01

    Hydrotectonics combines the principles of hydraulics and rock mechanics. The hypothesis assumes that: (1) no faults are truly planar, (2) opposing noncongruent wavy wallrock surfaces form chambers and bottlenecks along the fault, and (3) most thrusting occurs beneath the water table. These physical constraints permit the following dynamics. Shear displacement accompanying faulting must constantly change the volume of each chamber. Addition of ground water liquefies dry fault breccia to a heavy incompressible viscous muddy breccia I call fault slurry. When the volume of a chamber along a thrust fault decreases faster than its fault slurry can escape laterally, overpressurized slurry is hydraulically injected into the base of near-vertical fractures in the otherwise impervious overriding plate. Breccia pipes commonly form where such fissures intersect. Alternating decrease and increase in volume of the chamber subjects this injection slurry to reversible surges that not only raft and abrade huge clasts sporadically spalled from the walls of the conduit but also act as a forceful hydraulic ram which periodically widens the conduit and extends its top. If the pipe perforates a petroleum reservoir, leaking hydrocarbons float to its top. Sudden faulting may generate a powerful water hammer that can be amplified at some distal narrow ends of the anastomosing plumbing system, where the shock may produce shatter cones. If vented on the Earth's surface, the muddy breccia, now called extrusion slurry, forms a mud volcano. This hypothesis suggests that many highly disturbed features presently attributed to such catastrophic processes as subsurface explosions or meteorite impacts are due to the rheology of tectonic slurry in an intermittently reactivated pressure-relief tube rooted in a powerful reciprocating hydrotectonic pump activated by a long-lived deep-seated thrust fault.

  4. Transcultural care principles, human rights, and ethical considerations.

    PubMed

    Leininger, M

    1991-01-01

    During the past three decades, the author has developed and used some general principles to guide transcultural instruction, practice and research. These principles were developed from my transcultural care theory, research studies and direct clinical experiences, consultation and general writings on the subject [Leininger 1967, 1970, 1973, 1976, 1978, 1979, 1980, 1981, 1984a, 1984b, 1988, 1989, 1990]. The principles include some assumptive premises with regard to universal and diverse considerations of human beings with the importance to know and respect the cultural rights of people in order to provide meaningful, satisfying and appropriate culture care to people. Through the years, a number of nursing students, faculty, and clinicians have used these principles, rights and ethical considerations to guide them in their thinking and to protect client's human and ethical rights. Since many nurses frequently request copies of these statements for teaching, consultation and clinical work, they are published below with this intent in mind.

  5. A closer look at Fermat's principle

    NASA Astrophysics Data System (ADS)

    Se-yuen, Mak

    1986-11-01

    According to Fermat's principle, a ray of light travelling between two points traverses a path such that the time taken is a stationary value. However, in many textbooks the principle is often stated less rigorously by saying that a light ray follows the path of least time. Examples in which a ray traverses a path requiring a non-minimum time are, however, not uncommon for both reflection and refraction at spherical/cylindrical surfaces. Kaushik and Sukheeja (1984) gave an example of a path of maximum time in reflection while Halliday and Resnick (1966) gave an example of a path of maximum time in refraction when the angle of incidence is zero. The author first discusses the general condition for obtaining stationary optical paths in reflection by a spherical surface; then he considers the similar situation in refraction.

  6. The base rate principle and the fairness principle in social judgment.

    PubMed

    Cao, Jack; Banaji, Mahzarin R

    2016-07-01

    Meet Jonathan and Elizabeth. One person is a doctor and the other is a nurse. Who is the doctor? When nothing else is known, the base rate principle favors Jonathan to be the doctor and the fairness principle favors both individuals equally. However, when individuating facts reveal who is actually the doctor, base rates and fairness become irrelevant, as the facts make the correct answer clear. In three experiments, explicit and implicit beliefs were measured before and after individuating facts were learned. These facts were either stereotypic (e.g., Jonathan is the doctor, Elizabeth is the nurse) or counterstereotypic (e.g., Elizabeth is the doctor, Jonathan is the nurse). Results showed that before individuating facts were learned, explicit beliefs followed the fairness principle, whereas implicit beliefs followed the base rate principle. After individuating facts were learned, explicit beliefs correctly aligned with stereotypic and counterstereotypic facts. Implicit beliefs, however, were immune to counterstereotypic facts and continued to follow the base rate principle. Having established the robustness and generality of these results, a fourth experiment verified that gender stereotypes played a causal role: when both individuals were male, explicit and implicit beliefs alike correctly converged with individuating facts. Taken together, these experiments demonstrate that explicit beliefs uphold fairness and incorporate obvious and relevant facts, but implicit beliefs uphold base rates and appear relatively impervious to counterstereotypic facts. PMID:27325760

  7. On a Variational Principle of Hamilton’s Type for Irreversible Processes

    NASA Astrophysics Data System (ADS)

    Ichiyanagi, Masakazu

    1993-08-01

    A new variational principle of Hamilton’s type is proposed which is applicable to odd-order equations of nonequilibrium processes. This theory rests upon a generalization of Hamilton’s principle suggested by Djukic and Vujanovic. It is shown that the principle of the least dissipation of energy can be formulated in the form of Hamilton’s type. A variational principle for the Fokker-Planck equation is also proposed.

  8. Principles of Play for Soccer

    ERIC Educational Resources Information Center

    Ouellette, John

    2004-01-01

    Soccer coaches must understand the principles of play if they want to succeed. The principles of play are the rules of action that support the basic objectives of soccer and the foundation of a soccer coaching strategy. They serve as a set of permanent criteria that coaches can use to evaluate the efforts of their team. In this article, the author…

  9. Ideario Educativo (Principles of Education).

    ERIC Educational Resources Information Center

    Consejo Nacional Tecnico de la Educacion (Mexico).

    This document is an English-language abstract (approximately 1,500 words) which discusses an overall educational policy for Mexico based on Constitutional principles and those of humanism. The basic principles that should guide Mexican education as seen by the National Technical Council for Education are the following: (1) love of country; (2)…

  10. Multimedia Principle in Teaching Lessons

    ERIC Educational Resources Information Center

    Kari Jabbour, Khayrazad

    2012-01-01

    Multimedia learning principle occurs when we create mental representations from combining text and relevant graphics into lessons. This article discusses the learning advantages that result from adding multimedia learning principle into instructions; and how to select graphics that support learning. There is a balance that instructional designers…

  11. Meaty Principles for Environmental Educators.

    ERIC Educational Resources Information Center

    Rockcastle, V. N.

    1985-01-01

    Suggests that educated persons should be exposed to a body of conceptual knowledge which includes basic principles of the biological and physical sciences. Practical examples involving force, sound, light, waves, and density of water are cited. A lesson on animal tracks using principles of force and pressure is also described. (DH)

  12. Hamilton's principle in stochastic mechanics

    NASA Astrophysics Data System (ADS)

    Pavon, Michele

    1995-12-01

    In this paper we establish three variational principles that provide new foundations for Nelson's stochastic mechanics in the case of nonrelativistic particles without spin. The resulting variational picture is much richer and of a different nature with respect to the one previously considered in the literature. We first develop two stochastic variational principles whose Hamilton-Jacobi-like equations are precisely the two coupled partial differential equations that are obtained from the Schrödinger equation (Madelung equations). The two problems are zero-sum, noncooperative, stochastic differential games that are familiar in the control theory literature. They are solved here by means of a new, absolutely elementary method based on Lagrange functionals. For both games the saddle-point equilibrium solution is given by the Nelson's process and the optimal controls for the two competing players are precisely Nelson's current velocity v and osmotic velocity u, respectively. The first variational principle includes as special cases both the Guerra-Morato variational principle [Phys. Rev. D 27, 1774 (1983)] and Schrödinger original variational derivation of the time-independent equation. It also reduces to the classical least action principle when the intensity of the underlying noise tends to zero. It appears as a saddle-point action principle. In the second variational principle the action is simply the difference between the initial and final configurational entropy. It is therefore a saddle-point entropy production principle. From the variational principles it follows, in particular, that both v(x,t) and u(x,t) are gradients of appropriate principal functions. In the variational principles, the role of the background noise has the intuitive meaning of attempting to contrast the more classical mechanical features of the system by trying to maximize the action in the first principle and by trying to increase the entropy in the second. Combining the two variational

  13. Quantum Superposition, Collapse, and the Default Specification Principle

    NASA Astrophysics Data System (ADS)

    Nikkhah Shirazi, Armin

    2014-03-01

    Quantum Superposition and collapse lie at the heart of the difficulty in understanding what quantum mechanics is exactly telling us about reality. We present here a principle which permits one to formulate a simple and general mathematical model that abstracts these features out of quantum theory. A precise formulation of this principle in terms of a set-theoretic axiom added to standard set theory may directly connect the foundations of physics to the foundations of mathematics.

  14. Quantum maximum entropy principle for fractional exclusion statistics.

    PubMed

    Trovato, M; Reggiani, L

    2013-01-11

    Using the Wigner representation, compatibly with the uncertainty principle, we formulate a quantum maximum entropy principle for the fractional exclusion statistics. By considering anyonic systems satisfying fractional exclusion statistic, all the results available in the literature are generalized in terms of both the kind of statistics and a nonlocal description for excluson gases. Gradient quantum corrections are explicitly given at different levels of degeneracy and classical results are recovered when ℏ→0.

  15. Local completeness, drop theorem and Ekeland's variational principle

    NASA Astrophysics Data System (ADS)

    Qiu, Jing-Hui

    2005-11-01

    By using a very general drop theorem in locally convex spaces we obtain some extended versions of Ekeland's variational principle, which only need assume local completeness of some related sets and improve Hamel's recent results. From this, we derive some new versions of Caristi's fixed points theorems. In the framework of locally convex spaces, we prove that Danes' drop theorem, Ekeland's variational principle, Caristi's fixed points theorem and Phelps lemma are equivalent to each other.

  16. An Inconvenient Principle

    NASA Astrophysics Data System (ADS)

    Bellac, Michel Le

    2014-11-01

    At the end of the XIXth century, physics was dominated by two main theories: classical (or Newtonian) mechanics and electromagnetism. To be entirely correct, we should add thermodynamics, which seemed to be grounded on different principles, but whose links with mechanics were progressively better understood thanks to the work of Maxwell and Boltzmann, among others. Classical mechanics, born with Galileo and Newton, claimed to explain the motion of lumps of matter under the action of forces. The paradigm for a lump of matter is a particle, or a corpuscle, which one can intuitively think of as a billiard ball of tiny dimensions, and which will be dubbed a micro-billiard ball in what follows. The second main component of XIXth century physics, electromagnetism, is a theory of the electric and magnetic fields and also of optics, thanks to the synthesis between electromagnetism and optics performed by Maxwell, who understood that light waves are nothing other than a particular case of electromagnetic waves. We had, on the one hand, a mechanical theory where matter exhibiting a discrete character (particles) was carried along well localized trajectories and, on the other hand, a wave theory describing continuous phenomena which did not involve transport of matter. The two theories addressed different domains, the only obvious link being the law giving the force on a charged particle submitted to an electromagnetic field, or Lorentz force. In 1905, Einstein put an end to this dichotomic wave/particle view and launched two revolutions of physics: special relativity and quantum physics. First, he showed that Newton's equations of motion must be modified when the particle velocities are not negligible with respect to that of light: this is the special relativity revolution, which introduces in mechanics a quantity characteristic of optics, the velocity of light. However, this is an aspect of the Einsteinian revolution which will not interest us directly, with the exception

  17. LeChâtelier's Principle in the Sciences

    NASA Astrophysics Data System (ADS)

    Thomsen, Volker B. E.

    2000-02-01

    LeChâtelier's principle of chemical equilibrium is actually a very general statement about systems in equilibrium and their behavior when subjected to external force or stress. Although one almost never finds mention of his name or law in other sciences, analogous principles and concepts do exist. In this note we examine some of the similar forms taken by this chemical principle in the fields of physics, geology, biology, and economics. Lenz's law in physics is an example of electromagnetic equilibrium and the geological principle of isostatic uplift concerns mechanical equilibrium. Both are strictly consequences of conservation of energy. LeChâtelier's principle deals with thermodynamic equilibrium and involves both the first and second laws of thermodynamics. The concept of homeostasis in biology and the economic law of supply and demand are both equilibrium-like principles, but involve systems in the steady state. However, all these principles involve the stability of the system under consideration and the analogies presented may be useful in the teaching of LeChâtelier's principle.

  18. On Generalized Non-holonomic Systems

    NASA Astrophysics Data System (ADS)

    Balseiro, P.; Solomin, J. E.

    2008-04-01

    Generalized non-holonomic mechanical systems are analyzed from a geometric point of view. The existence and uniqueness of solutions, D’Alembert principle, Gauss principle of minimal constraint, the non-holonomic momentum and Gibbs-Appell equations for such systems are studied in an invariant Lagrangian framework.

  19. General Semantics in the Labor Room.

    ERIC Educational Resources Information Center

    Keller, Jo

    This paper provides a review of some basic general semantic principles and then applies them to the area of prenatal classes and labor room practices. It first presents an overview of the principle that language is not a neutral factor in human perceptions but an active, reactive force. Next, it looks at the relationship between language and…

  20. Cosmological implications of the Machian principle

    NASA Astrophysics Data System (ADS)

    Fahr, Hans J.; Zoennchen, Jochen H.

    2006-12-01

    The famous idea of Ernst Mach concerning the non-absolute but relational character of particle inertia is taken up in this paper and is reinvestigated with respect to its cosmological implications. From Thirring’s general relativistic study of the old Newtonian problem of the relativity of rotations in different reference systems, it appears that the equivalence principle with respect to rotating reference systems, if at all, can only be extended to the system of the whole universe, if the mass of the universe scales with the effective radius or extent of the universe. A reanalysis of Thirring’s derivations still reveals this astonishing result, and thus the general question must be posed: how serious this result has to be taken with respect to cosmological implications. As we will show, the equivalence principle is, in fact, fulfilled by a universe with vanishing curvature, i.e. with a curvature parameter k = 0, which just has the critical density ρ _{{crit}} = {3H2 } {8π G}, where H is the Hubble constant. It turns out, however, that this principle can only permanently be fulfilled in an evolving cosmos, if the cosmic mass density, different from its conventional behaviour, varies with the reciprocal of the squared cosmic scale. This, in fact, would automatically be realized, if the mass of each cosmic particle scales with the scale of the universe. The latter fact, on one hand, is a field-theoretical request from a general relativistic field theory which fulfills H. Weyl’s requirement of a conformal scale invariance. On the other hand, it can perhaps also be concluded on purely physical grounds, when taking into account that as source of the cosmic metrics only an effective mass density can be taken. This mass density represents the bare mass density reduced by its mass equivalent of gravitational self-binding energy. Some interesting cosmological conclusions connected with this fact are pointed out in this paper.

  1. Principles and techniques for designing precision machines

    SciTech Connect

    Hale, L C

    1999-02-01

    This thesis is written to advance the reader's knowledge of precision-engineering principles and their application to designing machines that achieve both sufficient precision and minimum cost. It provides the concepts and tools necessary for the engineer to create new precision machine designs. Four case studies demonstrate the principles and showcase approaches and solutions to specific problems that generally have wider applications. These come from projects at the Lawrence Livermore National Laboratory in which the author participated: the Large Optics Diamond Turning Machine, Accuracy Enhancement of High- Productivity Machine Tools, the National Ignition Facility, and Extreme Ultraviolet Lithography. Although broad in scope, the topics go into sufficient depth to be useful to practicing precision engineers and often fulfill more academic ambitions. The thesis begins with a chapter that presents significant principles and fundamental knowledge from the Precision Engineering literature. Following this is a chapter that presents engineering design techniques that are general and not specific to precision machines. All subsequent chapters cover specific aspects of precision machine design. The first of these is Structural Design, guidelines and analysis techniques for achieving independently stiff machine structures. The next chapter addresses dynamic stiffness by presenting several techniques for Deterministic Damping, damping designs that can be analyzed and optimized with predictive results. Several chapters present a main thrust of the thesis, Exact-Constraint Design. A main contribution is a generalized modeling approach developed through the course of creating several unique designs. The final chapter is the primary case study of the thesis, the Conceptual Design of a Horizontal Machining Center.

  2. An Academic Formulas List: New Methods in Phraseology Research

    ERIC Educational Resources Information Center

    Simpson-Vlach, Rita; Ellis, Nick C.

    2010-01-01

    This research creates an empirically derived, pedagogically useful list of formulaic sequences for academic speech and writing, comparable with the Academic Word List (Coxhead 2000), called the Academic Formulas List (AFL). The AFL includes formulaic sequences identified as (i) frequent recurrent patterns in corpora of written and spoken language,…

  3. Le Chatelier's principle with multiple relaxation channels

    NASA Astrophysics Data System (ADS)

    Gilmore, R.; Levine, R. D.

    1986-05-01

    Le Chatelier's principle is discussed within the constrained variational approach to thermodynamics. The formulation is general enough to encompass systems not in thermal (or chemical) equilibrium. Particular attention is given to systems with multiple constraints which can be relaxed. The moderation of the initial perturbation increases as additional constraints are removed. This result is studied in particular when the (coupled) relaxation channels have widely different time scales. A series of inequalities is derived which describes the successive moderation as each successive relaxation channel opens up. These inequalities are interpreted within the metric-geometry representation of thermodynamics.

  4. The uncertainty principle and quantum chaos

    NASA Technical Reports Server (NTRS)

    Chirikov, Boris V.

    1993-01-01

    The conception of quantum chaos is described in some detail. The most striking feature of this novel phenomenon is that all the properties of classical dynamical chaos persist here but, typically, on the finite and different time scales only. The ultimate origin of such a universal quantum stability is in the fundamental uncertainty principle which makes discrete the phase space and, hence, the spectrum of bounded quantum motion. Reformulation of the ergodic theory, as a part of the general theory of dynamical systems, is briefly discussed.

  5. Lagrange's principle in extremum problems with constraints

    NASA Astrophysics Data System (ADS)

    Avakov, E. R.; Magaril-Il'yaev, G. G.; Tikhomirov, V. M.

    2013-06-01

    In this paper a general result concerning Lagrange's principle for so-called smoothly approximately convex problems is proved which encompasses necessary extremum conditions for mathematical and convex programming, the calculus of variations, Lyapunov problems, and optimal control problems with phase constraints. The problem of local controllability for a dynamical system with phase constraints is also considered. In an appendix, results are presented that relate to the development of a 'Lagrangian approach' to problems where regularity is absent and classical approaches are meaningless. Bibliography: 33 titles.

  6. 47 CFR 32.6720 - General and administrative.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... budget analysis and control, and general accounting (accounting principles and procedures and journals...) Occupational medical services; (5) Job analysis and salary programs; (6) Labor relations activities;...

  7. 48 CFR 49.109-1 - General.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false General. 49.109-1 Section 49.109-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.109-1 General. When a termination settlement has...

  8. Generalized Entropic Uncertainty Relations with Tsallis' Entropy

    NASA Technical Reports Server (NTRS)

    Portesi, M.; Plastino, A.

    1996-01-01

    A generalization of the entropic formulation of the Uncertainty Principle of Quantum Mechanics is considered with the introduction of the q-entropies recently proposed by Tsallis. The concomitant generalized measure is illustrated for the case of phase and number operators in quantum optics. Interesting results are obtained when making use of q-entropies as the basis for constructing generalized entropic uncertainty measures.

  9. 14 CFR 1203.300 - General.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false General. 1203.300 Section 1203.300 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM Classification Principles and Considerations § 1203.300 General. In general, the types of...

  10. 14 CFR 1203.300 - General.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true General. 1203.300 Section 1203.300 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM Classification Principles and Considerations § 1203.300 General. In general, the types of...

  11. 14 CFR 1203.300 - General.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false General. 1203.300 Section 1203.300 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM Classification Principles and Considerations § 1203.300 General. In general, the types of...

  12. 14 CFR 1203.300 - General.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false General. 1203.300 Section 1203.300 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM Classification Principles and Considerations § 1203.300 General. In general, the types of...

  13. General Education: The Community College's Unfulfilled Agenda.

    ERIC Educational Resources Information Center

    Vaughan, George B.

    Community colleges have always embraced general education in principle, but have largely failed to deliver a meaningful program of general studies. Definitions of general education stress the importance of teaching the common knowledge, cultural and environmental understanding, skills, values, and attitudes needed by each individual to be an…

  14. 14 CFR § 1203.300 - General.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false General. § 1203.300 Section § 1203.300 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM Classification Principles and Considerations § 1203.300 General. In general, the types of...

  15. Epigenetics: Principles and Practice

    PubMed Central

    Hamilton, James P.

    2011-01-01

    Epigenetics is defined as heritable changes in gene expression that are, unlike mutations, not attributable to alterations in the sequence of DNA. The predominant epigenetic mechanisms are DNA methylation, modifications to chromatin, loss of imprinting and non-coding RNA. Epigenetic regulation of gene expression appears to have long-term effects and wide-ranging effects on health. Diet and environmental exposures may potentially alter the level and scope of epigenetic regulation, thus interesting developments in the study of epigenetics might explain correlations that researchers have found between lifestyle and risk of disease. Aberrant epigenetic patterns have been linked to a number of digestive diseases including Barrett's esophagus, cirrhosis, inflammatory bowel disease, and numerous gastrointestinal malignancies. In fact, many exciting discoveries about epigenetics in general have been made by studying diseases of the gastrointestinal tract and hepatobiliary tree. Epigenetic modifications of DNA in cancer and precancerous lesions offer hope and the promise of novel biomarkers for early cancer detection, prediction, prognosis, and response to treatment. Furthermore, reversal of epigenetic changes represents a potential target of novel therapeutic strategies and medication design. In the future, it is anticipated that innovative diagnostic tests, treatment regimens, and even lifestyle modifications will be based on epigenetic mechanisms and be incorporated into the practice of medicine. PMID:21734376

  16. Basic Principles of Ultrasound

    NASA Astrophysics Data System (ADS)

    Robinson, Teresa M.

    Ultrasound has been used in medicine for at least 50 years. Its current importance can be judged by the fact that, of all the various kinds of diagnostic images produced in the world, 1 in 4 is an ultrasound scan. Ultrasound energy is exactly like sound energy, it is a variation in the pressure within a medium. The only difference is that the rate of variation of pressure, the frequency of the wave, is too rapid for humans to hear. Medical ultrasound lies within a frequency range of 30 kHz to 500 MHz. Generally, the lower frequencies (30 kHz to 3 MHz) are for therapeutic purposes, the higher ones (2 to 40 MHz) are for diagnosis (imaging and Doppler), the very highest (50 to 500 MHz) are for microscopic images. For diagnostic purposes two main techniques are employed; the pulse-echo method is used to create images of tissue distribution; the Doppler effect is used to assess tissue movement and blood flow.

  17. Principles of adhesion.

    PubMed

    Baier, R E

    1992-01-01

    Understanding interfacial phenomena has been of direct relevance and practical benefit to extending the use of dental adhesives. Both surface physics, which describes properties of the inorganic materials' interfacial zones from their actual phase boundaries toward the bulk phases of the solids, and surface chemistry, which describes phenomena at the solid/biological interface and beyond it into the variable organic environment, have been important. High-energy materials include solids that are very hard, have high melting points, strong intermolecular forces, and basically crystalline structures, such as dental enamel. Low-energy materials, such as dentinal collagen, salivary films, and the organic resins of restorative materials, are softer, lower melting, and have weaker intermolecular forces, poorer crystallinity, and surface energies generally less than 100 ergs/cm. It has been a properly renewed emphasis on wetting of dental surfaces and their modification by primer coats, displacing or mixing with water and adsorbed proteinaceous films, that has promoted the success of many recently developed fourth-generation dentin adhesives. Their improved wettability for biological phases correlates directly with their better infiltration and anchoring of composites.

  18. Teaching Evolutionary Theory as General Education.

    ERIC Educational Resources Information Center

    Todd, Paul

    1984-01-01

    Provides a rationale for including evolution as part of a college general education curriculum, discussing the content of evolutionary theory, instructional principles, Darwin's contributions, evolution and religion, and the relationship of evolution with current events. (DMM)

  19. 29 CFR 785.33 - General.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... General. The principles which apply in determining whether or not time spent in travel is working time depend upon the kind of travel involved. The subject is discussed in §§ 785.35 to 785.41, which...

  20. Economic principles motivating social attention in humans.

    PubMed

    Hayden, Benjamin Y; Parikh, Purak C; Deaner, Robert O; Platt, Michael L

    2007-07-22

    We know little about the processes by which we evaluate the opportunity to look at another person. We propose that behavioural economics provides a powerful approach to understanding this basic aspect of social attention. We hypothesized that the decision process culminating in attention to another person follows the same economic principles that govern choices about rewards such as food, drinks and money. Specifically, such rewards are discounted as a function of time, are tradable for other rewards, and reinforce work. Behavioural and neurobiological evidence suggests that looking at other people can also be described as rewarding, but to what extent these economic principles apply to social orienting remains unknown. Here, we show that the opportunity to view pictures of the opposite sex is discounted by delay to viewing, substitutes for money and reinforces work. The reward value of photos of the opposite sex varied with physical attractiveness and was greater in men, suggesting differential utility of acquiring visual information about the opposite sex in men and women. Together, these results demonstrate that choosing whom to look at follows a general set of economic principles, implicating shared neural mechanisms in both social and non-social decision making.

  1. Economic principles motivating social attention in humans.

    PubMed

    Hayden, Benjamin Y; Parikh, Purak C; Deaner, Robert O; Platt, Michael L

    2007-07-22

    We know little about the processes by which we evaluate the opportunity to look at another person. We propose that behavioural economics provides a powerful approach to understanding this basic aspect of social attention. We hypothesized that the decision process culminating in attention to another person follows the same economic principles that govern choices about rewards such as food, drinks and money. Specifically, such rewards are discounted as a function of time, are tradable for other rewards, and reinforce work. Behavioural and neurobiological evidence suggests that looking at other people can also be described as rewarding, but to what extent these economic principles apply to social orienting remains unknown. Here, we show that the opportunity to view pictures of the opposite sex is discounted by delay to viewing, substitutes for money and reinforces work. The reward value of photos of the opposite sex varied with physical attractiveness and was greater in men, suggesting differential utility of acquiring visual information about the opposite sex in men and women. Together, these results demonstrate that choosing whom to look at follows a general set of economic principles, implicating shared neural mechanisms in both social and non-social decision making. PMID:17490943

  2. Principles of allocation of health care resources.

    PubMed Central

    Knox, E G

    1978-01-01

    The methods and principles of allocating centrally provided health care resources to regions and areas are reviewed using the report of the Resource Allocation Working Party (RAWP) (Department of Health and Social Security, 1976) and the consultative document (Department of Health and Social Security, 1976a) as a basis. A range of practical problems arising from these papers (especially the report of the RAWP) is described and traced to the terms of reference. It is concluded that the RAWP misinterpreted aspects of social and administrative reality, and it failed to recognise clearly that the several principles on which it had to work conflicted with each other and demanded decisions of priority. The consequential errors led to (a) an injudicious imposition of 'objectivity' at all levels of allocation, (b) an unjustified insistence that the same method be used at each administrative level in an additive and transitive manner, (c) the exclusion of general practitioner services from their considerations, (d) a failure to delineate those decisions which are in fact political decisions, thus to concatenate them, inappropriately, with technical and professional issues. The main requirement in a revised system is for a mechanism which allocates different priorities to different principles at each appropriate administrative and distributive level, and adapts the working methods of each tier to meet separately defined objectives. PMID:262585

  3. Variational Principle for Planetary Interiors

    NASA Astrophysics Data System (ADS)

    Zeng, Li; Jacobsen, Stein B.

    2016-09-01

    In the past few years, the number of confirmed planets has grown above 2000. It is clear that they represent a diversity of structures not seen in our own solar system. In addition to very detailed interior modeling, it is valuable to have a simple analytical framework for describing planetary structures. The variational principle is a fundamental principle in physics, entailing that a physical system follows the trajectory, which minimizes its action. It is alternative to the differential equation formulation of a physical system. Applying the variational principle to the planetary interior can beautifully summarize the set of differential equations into one, which provides us some insight into the problem. From this principle, a universal mass-radius relation, an estimate of the error propagation from the equation of state to the mass-radius relation, and a form of the virial theorem applicable to planetary interiors are derived.

  4. [Ancient DNA: principles and methodologies].

    PubMed

    De Angelis, Flavio; Scorrano, Gabriele; Rickards, Olga

    2013-01-01

    Paleogenetics is providing increasing evidence about the biological characteristics of ancient populations. This paper examines the guiding principles and methodologies to the study of ancient DNA with constant references to the state of the art in this fascinating disciplin.

  5. Get Provoked: Applying Tilden's Principles.

    ERIC Educational Resources Information Center

    Shively, Carol A.

    1995-01-01

    This address given to the Division of Interpretation, Yellowstone National Park, Interpretive Training, June 1993, examines successes and failures in interpretive programs for adults and children in light of Tilden's principles. (LZ)

  6. No-signaling principle can determine optimal quantum state discrimination.

    PubMed

    Bae, Joonwoo; Hwang, Won-Young; Han, Yeong-Deok

    2011-10-21

    We provide a general framework of utilizing the no-signaling principle in derivation of the guessing probability in the minimum-error quantum state discrimination. We show that, remarkably, the guessing probability can be determined by the no-signaling principle. This is shown by proving that, in the semidefinite programing for the discrimination, the optimality condition corresponds to the constraint that quantum theory cannot be used for a superluminal communication. Finally, a general bound to the guessing probability is presented in a closed form.

  7. Multimodal electromechanical model of piezoelectric transformers by Hamilton's principle.

    PubMed

    Nadal, Clement; Pigache, Francois

    2009-11-01

    This work deals with a general energetic approach to establish an accurate electromechanical model of a piezoelectric transformer (PT). Hamilton's principle is used to obtain the equations of motion for free vibrations. The modal characteristics (mass, stiffness, primary and secondary electromechanical conversion factors) are also deduced. Then, to illustrate this general electromechanical method, the variational principle is applied to both homogeneous and nonhomogeneous Rosen-type PT models. A comparison of modal parameters, mechanical displacements, and electrical potentials are presented for both models. Finally, the validity of the electrodynamical model of nonhomogeneous Rosen-type PT is confirmed by a numerical comparison based on a finite elements method and an experimental identification.

  8. Minimum Principles in Motor Control.

    PubMed

    Engelbrecht, Sascha E.

    2001-06-01

    Minimum (or minimal) principles are mathematical laws that were first used in physics: Hamilton's principle and Fermat's principle of least time are two famous example. In the past decade, a number of motor control theories have been proposed that are formally of the same kind as the minimum principles of physics, and some of these have been quite successful at predicting motor performance in a variety of tasks. The present paper provides a comprehensive review of this work. Particular attention is given to the relation between minimum theories in motor control and those used in other disciplines. Other issues around which the review is organized include: (1) the relation between minimum principles and structural models of motor planning and motor control, (2) the empirically-driven development of minimum principles and the danger of circular theorizing, and (3) the design of critical tests for minimum theories. Some perspectives for future research are discussed in the concluding section of the paper. Copyright 2001 Academic Press. PMID:11401453

  9. Maximum entropy principle and relativistic hydrodynamics

    NASA Astrophysics Data System (ADS)

    van Weert, Ch. G.

    1982-04-01

    A relativistic theory of hydrodynamics applicable beyond the hydrodynamic regime is developed on the basis of the maximum entropy principle. This allows the construction of a unique statistical operator representing the state of the system as specified by the values of the hydrodynamical densities. Special attention is paid to the thermodynamic limit and the virial theorem which leads to an expression for the pressure in terms of the field-theoretic energymomentum tensor of Coleman and Jackiw. It is argued that outside the hydrodynamic regime the notion of a local Gibbs relation, as usually postulated, must be abandoned in general. In the nontext of the linear approximation, the memory-retaining and non-local generalizations of the relativistic Navier-Stokes equations are derived from the underlying Heisenberg equations of motion. The formal similarity to the Zwanzig-Mori description of non-relativistic fluids is expounded.

  10. Positronium, antihydrogen, light, and the equivalence principle

    NASA Astrophysics Data System (ADS)

    Karshenboim, Savely G.

    2016-07-01

    While discussing a certain generic difference in effects of gravity on particles and antiparticles, various neutral particles (i.e. the particles which are identical with their antiparticles) could be a perfect probe. One such neutral particles is the positronium atom, which has been available for precision experiments for a few decades. The other important neutral particle is the photon. Behavior of light in the presence of a gravitational field has been the key both to build and develop the theory of general relativity and to verify it experimentally. The very idea of antigravity for antimatter strongly contradicts both the principles of general relativity and its experimentally verified consequences. Consideration of existing experimental results on photons and positrons makes antigravity impossible and leads to a conclusion that the deviation of the ratio of acceleration of the free fall of particles and antiparticles cannot exceed the level of 1× {10}-5.

  11. Examining the suitability of the principle of subsidiarity for bioethics.

    PubMed

    Kotalik, Jaro

    2010-12-01

    The political and social principle of subsidiarity can be useful as a general principle of bioethics. The principle states that only those decisions and tasks that cannot be effectively decided upon or performed by a supported or subsidized lower level authority ought to be relegated to a more central or higher authority. The concept of subsidiarity has been embedded tacitly in Western political thought for two millennia, but it has been articulated expressly only in the twentieth century. The principle has unique strengths: it is the only principle that addresses the issue of locus of decision making; it is strongly linked to human dignity, democracy, and solidarity; and it can assist in reaching agreements on the common good. There are also potential drawbacks that need to be taken into account when developing rules and guidelines for the principle's application in bioethics. The principle is particularly helpful in public health ethics, but it is also of use in the ethics of personal care and human research ethics. PMID:21338030

  12. 60 FR 30609 - Principles of Public Information

    Federal Register 2010, 2011, 2012, 2013, 2014

    1995-06-09

    ... LIBRARIES AND INFORMATION SCIENCE Principles of Public Information AGENCY: National Commission on Libraries... Commission on Libraries and Information Science (NCLIS) developed and adopted Principles of Public... National Commission on Libraries and Information Science offers these Principles of Public......

  13. The precautionary principle and ecological hazards of genetically modified organisms.

    PubMed

    Giampietro, Mario

    2002-09-01

    This paper makes three points relevant to the application of the precautionary principle to the regulation of GMOs. i) The unavoidable arbitrariness in the application of the precautionary principle reflects a deeper epistemological problem affecting scientific analyses of sustainability. This requires understanding the difference between the concepts of "risk", "uncertainty" and "ignorance". ii) When dealing with evolutionary processes it is impossible to ban uncertainty and ignorance from scientific models. Hence, traditional risk analysis (probability distributions and exact numerical models) becomes powerless. Other forms of scientific knowledge (general principles or metaphors) may be useful alternatives. iii) The existence of ecological hazards per se should not be used as a reason to stop innovations altogether. However, the precautionary principle entails that scientists move away from the concept of "substantive rationality" (trying to indicate to society optimal solutions) to that of "procedural rationality" (trying to help society to find "satisficing" solutions). PMID:12436844

  14. Opinions of Social Workers in Turkey About the Principles on Die with Dignity.

    PubMed

    Duyan, Veli; Serpen, Ayşe Sezen; Duyan, Gülsüm; Yavuz, Sutay

    2016-12-01

    The conditions how people will spend their very last moments are an increasingly debated topic in Turkey. This study is planned to learn the opinions of Social Workers in Turkey on "Principles of a good death." The results of this study reveal that social workers in Turkey agree with principles of a good death in general. The degree of support for some specific principles changes by the sex and age of the participants. Despite the significant support given to principles by social workers, majority of them do not think that these principles are currently followed in medical and care institutions in Turkey.

  15. Principles of Chemistry (by Michael Munowitz)

    NASA Astrophysics Data System (ADS)

    Kovac, Reviewed By Jeffrey

    2000-05-01

    At a time when almost all general chemistry textbooks seem to have become commodities designed by marketing departments to offend no one, it is refreshing to find a book with a unique perspective. Michael Munowitz has written what I can only describe as a delightful chemistry book, full of conceptual insight, that uses a novel and interesting pedagogic strategy. This is a book that has much to recommend it. This is the best-written general chemistry book I have ever read. An editor with whom I have worked recently remarked that he felt his job was to help authors make their writing sing. Well, the writing in Principles of Chemistry sings with the full, rich harmonies and creative inventiveness of the King's Singers or Chanticleer. Here is the first sentence of the introduction: "Central to any understanding of the physical world is one discovery of paramount importance, a truth disarmingly simple yet profound in its implications: matter is not continuous." This is prose to be savored and celebrated. Principles of Chemistry has a distinct perspective on chemistry: the perspective of the physical chemist. The focus is on simplicity, what is common about molecules and reactions; begin with the microscopic and build bridges to the macroscopic. The author's perspective is clear from the organization of the book. After three rather broad introductory chapters, there are four chapters that develop the quantum mechanical theory of atoms and molecules, including a strong treatment of molecular orbital theory. Unlike many books, Principles of Chemistry presents the molecular orbital approach first and introduces valence bond theory later only as an approximation for dealing with more complicated molecules. The usual chapters on descriptive inorganic chemistry are absent (though there is an excellent chapter on organic and biological molecules and reactions as well as one on transition metal complexes). Instead, descriptive chemistry is integrated into the development of

  16. Principles of Chemistry (by Michael Munowitz)

    NASA Astrophysics Data System (ADS)

    Kovac, Reviewed By Jeffrey

    2000-05-01

    At a time when almost all general chemistry textbooks seem to have become commodities designed by marketing departments to offend no one, it is refreshing to find a book with a unique perspective. Michael Munowitz has written what I can only describe as a delightful chemistry book, full of conceptual insight, that uses a novel and interesting pedagogic strategy. This is a book that has much to recommend it. This is the best-written general chemistry book I have ever read. An editor with whom I have worked recently remarked that he felt his job was to help authors make their writing sing. Well, the writing in Principles of Chemistry sings with the full, rich harmonies and creative inventiveness of the King's Singers or Chanticleer. Here is the first sentence of the introduction: "Central to any understanding of the physical world is one discovery of paramount importance, a truth disarmingly simple yet profound in its implications: matter is not continuous." This is prose to be savored and celebrated. Principles of Chemistry has a distinct perspective on chemistry: the perspective of the physical chemist. The focus is on simplicity, what is common about molecules and reactions; begin with the microscopic and build bridges to the macroscopic. The author's perspective is clear from the organization of the book. After three rather broad introductory chapters, there are four chapters that develop the quantum mechanical theory of atoms and molecules, including a strong treatment of molecular orbital theory. Unlike many books, Principles of Chemistry presents the molecular orbital approach first and introduces valence bond theory later only as an approximation for dealing with more complicated molecules. The usual chapters on descriptive inorganic chemistry are absent (though there is an excellent chapter on organic and biological molecules and reactions as well as one on transition metal complexes). Instead, descriptive chemistry is integrated into the development of

  17. Investigating underlying principles to guide health impact assessment

    PubMed Central

    Fakhri, Ali; Maleki, Mohammadreza; Gohari, Mahmoodreza; Harris, Patrick

    2014-01-01

    Background: Many countries conduct Health Impact Assessment (HIA) of their projects and policies to predict their positive and negative health impacts. In recent years many guides have been developed to inform HIA practice, largely reflecting local developments in HIA. These guides have often been designed for specific contexts and specific need, making the choice between guides difficult. The objective of the current study is to identify underlying principles in order to guide HIA practice in Iran. Methods: This study was conducted in three stages: 1) Studies comparing HIA guidelines were reviewed to identify criteria used for comparison seeking emphasized principles. 2) The HIA characteristics extracted from published papers were categorized in order to determine the principles that could guide HIA practice. 3) Finally, these principles were agreed by experts using nominal group technique. Results: The review of the studies comparing HIA guides demonstrated there are no clear comparison criteria for reviewing HIA guides and no study mentioned HIA principles. Investigating the HIA principles from peer-reviewed papers, we found 14 issues. These were, considering of general features in planning and conducting HIAs such as HIA stream, level, timing and type, considering of the wider socio-political and economic context, considering of economic, technical and legal aspects of HIA and capacities for HIA, rationality and comprehensiveness, using appropriate evidence, elaborating on HIA relation to other forms of Impact Assessment, considering of equity, and encouraging intersectoral and interdisciplinary cooperation, involvement of stakeholders and transparency as underlying principles to guide HIA practice. The results emphasize how critical these technical as well as tactical considerations are in the early scoping step of an HIA which plans the conduct of the HIA in reponse to local contextual issues. Conclusion: Determining the principles of HIA from peer

  18. The 4th Thermodynamic Principle?

    SciTech Connect

    Montero Garcia, Jose de la Luz; Novoa Blanco, Jesus Francisco

    2007-04-28

    It should be emphasized that the 4th Principle above formulated is a thermodynamic principle and, at the same time, is mechanical-quantum and relativist, as it should inevitably be and its absence has been one of main the theoretical limitations of the physical theory until today.We show that the theoretical discovery of Dimensional Primitive Octet of Matter, the 4th Thermodynamic Principle, the Quantum Hexet of Matter, the Global Hexagonal Subsystem of Fundamental Constants of Energy and the Measurement or Connected Global Scale or Universal Existential Interval of the Matter is that it is possible to be arrived at a global formulation of the four 'forces' or fundamental interactions of nature. The Einstein's golden dream is possible.

  19. Principles of Virus Structural Organization

    PubMed Central

    Prasad, B.V. Venkataram; Schmid, Michael F

    2013-01-01

    Viruses, the molecular nanomachines infecting hosts ranging from prokaryotes to eukaryotes, come in different sizes, shapes and symmetries. Questions such as what principles govern their structural organization, what factors guide their assembly, how these viruses integrate multifarious functions into one unique structure have enamored researchers for years. In the last five decades, following Caspar and Klug's elegant conceptualization of how viruses are constructed, high resolution structural studies using X-ray crystallography and more recently cryo-EM techniques have provided a wealth of information on structures of variety of viruses. These studies have significantly furthered our understanding of the principles that underlie structural organization in viruses. Such an understanding has practical impact in providing a rational basis for the design and development of antiviral strategies. In this chapter, we review principles underlying capsid formation in a variety of viruses, emphasizing the recent developments along with some historical perspective. PMID:22297509

  20. Principle Paradigms Revisiting the Dublin Core 1:1 Principle

    ERIC Educational Resources Information Center

    Urban, Richard J.

    2012-01-01

    The Dublin Core "1:1 Principle" asserts that "related but conceptually different entities, for example a painting and a digital image of the painting, are described by separate metadata records" (Woodley et al., 2005). While this seems to be a simple requirement, studies of metadata quality have found that cultural heritage…