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Sample records for pittsburgh pa usa

  1. RadNet Air Data From Pittsburgh, PA

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Pittsburgh, PA from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  2. 75 FR 81469 - Safety Zone; Allegheny River, Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ...-2010-1082 and are available online by going to http://www.regulations.gov , inserting USCG-2010-1082 in.... 2064; Department of Homeland Security Delegation No. 0170.1. 0 2. Add Sec. 165.T08-1082 to read as follows: Sec. 165.T08-1082 Safety Zone; Allegheny River, Pittsburgh, PA. (a) Location. The following...

  3. [Proceedings of the] International Conference on Educational Data Mining (EDM) (3rd, Pittsburgh, PA, July 11-13, 2010)

    ERIC Educational Resources Information Center

    Baker, Ryan S. J. d., Ed.; Merceron, Agathe, Ed.; Pavlik, Philip I., Jr., Ed.

    2010-01-01

    The Third International Conference on Data Mining (EDM 2010) was held in Pittsburgh, PA, USA. It follows the second conference at the University of Cordoba, Spain, on July 1-3, 2009 and the first edition of the conference held in Montreal in 2008, and a series of workshops within the AAAI, AIED, EC-TEL, ICALT, ITS, and UM conferences. EDM 2011…

  4. 75 FR 56866 - Special Local Regulation; Monongahela River, Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-17

    ... special local regulation is needed to safeguard participants of the Pittsburgh Dragon Boat Festival from... because immediate action is needed to safeguard participants during the Pittsburgh Dragon Boat Festival... immediate action is needed to safeguard participants during the Pittsburgh Dragon Boat Festival from...

  5. 76 FR 55471 - Pittsburgh & West Virginia Railroad-Abandonment Exemption-in Allegheny County, PA; Wheeling...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-07

    ... Surface Transportation Board Pittsburgh & West Virginia Railroad--Abandonment Exemption--in Allegheny County, PA; Wheeling & Lake Erie Railway Company-- Discontinuance of Service Exemption--in Allegheny County, PA Pittsburgh & West Virginia Railroad (PWV) and Wheeling & Lake Erie Railway Company (WLE...

  6. Lifestyle characteristics assessment of Japanese in Pittsburgh, USA.

    PubMed

    Hirooka, Nobutaka; Takedai, Teiichi; D'Amico, Frank

    2012-04-01

    Lifestyle-related chronic diseases such as cancer and cardiovascular disease are the greatest public health concerns. Evidence shows Japanese immigrants to a westernized environment have higher incidence of lifestyle-related diseases. However, little is known about lifestyle characteristics related to chronic diseases for Japanese in a westernized environment. This study is examining the gap in lifestyle by comparing the lifestyle prevalence for Japanese in the US with the Japanese National Data (the National Health and Nutrition Survey in Japan, J-NHANS) as well as the Japan National Health Promotion in the twenty-first Century (HJ21) goals. Japanese adults were surveyed in Pittsburgh, USA, regarding their lifestyle (e.g., diet, exercise, smoking, stress, alcohol, and oral hygiene). The prevalence was compared with J-NHANS and HJ21 goals. Ninety-three responded (response rate; 97.9%). Japanese men (n = 38) and women (n = 55) in Pittsburgh smoke less than Japanese in Japan (P < 0.001 for both genders). Japanese in Pittsburgh perform less physical activity in daily life and have lower prevalence of walking more than 1 h per day (P < 0.001 for both genders). Japanese women in Pittsburgh have significantly higher prevalence of stress than in Japan (P = 0.004). Japanese men in Pittsburgh do not reach HJ21 goal in weight management, BMI, use of medicine or alcohol to sleep, and sleep quality. Japanese women in Pittsburgh do not reach HJ21 goal in weight management and sleep quality. In conclusion, healthy lifestyle promotion including exercise and physical activity intervention for Japanese living in a westernized environment is warranted.

  7. 75 FR 13488 - Expansion of Foreign-Trade Zone 33: Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Expansion of Foreign-Trade Zone 33: Pittsburgh, PA Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as amended (19 U.S.C. 81a-81u), the Foreign-Trade...

  8. 76 FR 72673 - Foreign-Trade Zone 33-Pittsburgh, PA; Application for Reorganization/Expansion

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Foreign-Trade Zone 33--Pittsburgh, PA; Application for Reorganization/Expansion An application has been submitted to the Foreign-Trade Zones (FTZ) Board (the Board) by the Regional...

  9. 77 FR 69591 - Expansion and Reorganization of Foreign-Trade Zone 33 Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Expansion and Reorganization of Foreign-Trade Zone 33 Pittsburgh, PA Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as amended (19 U.S.C. 81a-81u), the...

  10. Vulnerability studies and integrated assessments for hazard risk reduction in Pittsburgh, PA (Invited)

    NASA Astrophysics Data System (ADS)

    Klima, K.

    2013-12-01

    Today's environmental problems stretch beyond the bounds of most academic disciplines, and thus solutions require an interdisciplinary approach. For instance, the scientific consensus is changes in the frequency and severity of many types of extreme weather events are increasing (IPCC 2012). Yet despite our efforts to reduce greenhouse gases, we continue to experience severe weather events such as Superstorm Sandy, record heat and blizzards, and droughts. These natural hazards, combined with increased vulnerability and exposure, result in longer-lasting disruptions to critical infrastructure and business continuity throughout the world. In order to protect both our lives and the economy, we must think beyond the bounds of any one discipline to include an integrated assessment of relevant work. In the wake of recent events, New York City, Washington, DC, Chicago, and a myriad of other cities have turned to their academic powerhouses for assistance in better understanding their vulnerabilities. This talk will share a case study of the state of integrated assessments and vulnerability studies of energy, transportation, water, real estate, and other main sectors in Pittsburgh, PA. Then the talk will use integrated assessment models and other vulnerability studies to create coordinated sets of climate projections for use by the many public agencies and private-sector organizations in the region.

  11. Social Contact Networks and Mixing among Students in K-12 Schools in Pittsburgh, PA.

    PubMed

    Guclu, Hasan; Read, Jonathan; Vukotich, Charles J; Galloway, David D; Gao, Hongjiang; Rainey, Jeanette J; Uzicanin, Amra; Zimmer, Shanta M; Cummings, Derek A T

    2016-01-01

    Students attending schools play an important role in the transmission of influenza. In this study, we present a social network analysis of contacts among 1,828 students in eight different schools in urban and suburban areas in and near Pittsburgh, Pennsylvania, United States of America, including elementary, elementary-middle, middle, and high schools. We collected social contact information of students who wore wireless sensor devices that regularly recorded other devices if they are within a distance of 3 meters. We analyzed these networks to identify patterns of proximal student interactions in different classes and grades, to describe community structure within the schools, and to assess the impact of the physical environment of schools on proximal contacts. In the elementary and middle schools, we observed a high number of intra-grade and intra-classroom contacts and a relatively low number of inter-grade contacts. However, in high schools, contact networks were well connected and mixed across grades. High modularity of lower grades suggests that assumptions of homogeneous mixing in epidemic models may be inappropriate; whereas lower modularity in high schools suggests that homogenous mixing assumptions may be more acceptable in these settings. The results suggest that interventions targeting subsets of classrooms may work better in elementary schools than high schools. Our work presents quantitative measures of age-specific, school-based contacts that can be used as the basis for constructing models of the transmission of infections in schools.

  12. Social Contact Networks and Mixing among Students in K-12 Schools in Pittsburgh, PA

    PubMed Central

    Guclu, Hasan; Read, Jonathan; Vukotich, Charles J.; Galloway, David D.; Gao, Hongjiang; Rainey, Jeanette J.; Uzicanin, Amra; Zimmer, Shanta M.; Cummings, Derek A. T.

    2016-01-01

    Students attending schools play an important role in the transmission of influenza. In this study, we present a social network analysis of contacts among 1,828 students in eight different schools in urban and suburban areas in and near Pittsburgh, Pennsylvania, United States of America, including elementary, elementary-middle, middle, and high schools. We collected social contact information of students who wore wireless sensor devices that regularly recorded other devices if they are within a distance of 3 meters. We analyzed these networks to identify patterns of proximal student interactions in different classes and grades, to describe community structure within the schools, and to assess the impact of the physical environment of schools on proximal contacts. In the elementary and middle schools, we observed a high number of intra-grade and intra-classroom contacts and a relatively low number of inter-grade contacts. However, in high schools, contact networks were well connected and mixed across grades. High modularity of lower grades suggests that assumptions of homogeneous mixing in epidemic models may be inappropriate; whereas lower modularity in high schools suggests that homogenous mixing assumptions may be more acceptable in these settings. The results suggest that interventions targeting subsets of classrooms may work better in elementary schools than high schools. Our work presents quantitative measures of age-specific, school-based contacts that can be used as the basis for constructing models of the transmission of infections in schools. PMID:26978780

  13. View of the Warrington Avenue Bridge portal, inbound from Pittsburgh ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of the Warrington Avenue Bridge portal, inbound from Pittsburgh - Pittsburgh & Castle Shannon Railroad, Warrington Avenue Bridge, Overbrook Trolley Line, Crossing Warrington Avenue, Pittsburgh, Allegheny County, PA

  14. View of the Warrington Avenue Bridge portal, outbound from Pittsburgh ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of the Warrington Avenue Bridge portal, outbound from Pittsburgh - Pittsburgh & Castle Shannon Railroad, Warrington Avenue Bridge, Overbrook Trolley Line, Crossing Warrington Avenue, Pittsburgh, Allegheny County, PA

  15. 8. Photocopy of original drawing belonging to the Pittsburgh Department ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Photocopy of original drawing belonging to the Pittsburgh Department of Public Works, (n.d.). DRAWING NO. 1978: DETAILS AROUND EXPANSION SHOES. - North Side Point Bridge, Spanning Allegheny River at Point of Pittsburgh, Pittsburgh, Allegheny County, PA

  16. 75 FR 9867 - University of Pittsburgh, et al

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE International Trade Administration University of Pittsburgh, et al.; Notice of Consolidated Decision on...., NW. Washington, DC. Docket Number: 09-069. Applicant: University of Pittsburgh, Pittsburgh, PA...

  17. PERSPECTIVE VIEW FROM NORTHWEST OF PITTSBURGH HIGH SCHOOL FOR THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PERSPECTIVE VIEW FROM NORTHWEST OF PITTSBURGH HIGH SCHOOL FOR THE CREATIVE AND PERFORMING ARTS, BUILT 2003 BY THE FIRM OF MACLACHLAN CORNELIUS AND FILONI. - Pittsburgh High School for the Creative & Performing Arts, 111 Ninth Street, Pittsburgh, Allegheny County, PA

  18. Pittsburgh-Tuskegee Prostate Training Program

    DTIC Science & Technology

    2015-07-01

    ORGANIZATION: University of Pittsburgh Pittsburgh, PA 15213-2303 REPORT DATE: July 2015 TYPE OF REPORT: Final PREPARED FOR: U.S. Army Medical...ADDRESS(ES) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER University of Pittsburgh Office of Research 123 University Place Pittsburgh PA...15260 Tuskegee University Office of Sponsored Projects 4th Floor Carnegie Hall Tuskegee AL 36088 9. SPONSORING / MONITORING AGENCY NAME(S) AND

  19. Emerald ash borer and the urban forest: Changes in landslide potential due to canopy loss scenarios in the City of Pittsburgh, PA.

    PubMed

    Pfeil-McCullough, Erin; Bain, Daniel J; Bergman, Jeffery; Crumrine, Danielle

    2015-12-01

    Emerald ash borer is expected to kill thousands of ash trees in the eastern U.S. This research develops tools to predict the effect of ash tree loss from the urban canopy on landslide susceptibility in Pittsburgh, PA. A spatial model was built using the SINMAP (Stability INdex MAPping) model coupled with spatially explicit scenarios of tree loss (0%, 25%, 50%, and 75% loss of ash trees from the canopy). Ash spatial distributions were estimated via Monte Carlo methods and available vegetation plot data. Ash trees are most prevalent on steeper slopes, likely due to urban development patterns. Therefore, ash loss disproportionately increases hillslope instability. A 75% loss of ash resulted in roughly 800 new potential landslide initiation locations. Sensitivity testing reveals that variations in rainfall rates, and friction angles produce minor changes to model results relative to the magnitude of parameter variation, but reveal high model sensitivity to soil density and root cohesion values. The model predictions demonstrate the importance of large canopy species to urban hillslope stability, particularly on steep slopes and in areas where soils tend to retain water. To improve instability predictions, better characterization of urban soils, particularly spatial patterns of compaction and species specific root cohesion is necessary. The modeling framework developed in this research will enhance assessment of changes in landslide risk due to tree mortality, improving our ability to design economically and ecologically sustainable urban systems.

  20. A Comparative Study of Complementary and Alternative Medicine Use Among Heterosexually and Lesbian Identified Women: Data from the ESTHER Project (Pittsburgh, PA, 2003–2006)

    PubMed Central

    Matthews, Alicia; Markovic, Nina; Youk, Ada; Danielson, Michelle E.; Talbott, Evelyn O.

    2010-01-01

    Abstract Objectives The prevalence of complementary and alternative medicine (CAM) use among women in the United States is high. Little is known about how CAM use may differ based on sexual orientation. Study aims were to measure the prevalence of CAM use in a community sample of women, explore differences in CAM use patterns by sexual orientation, and identify correlates of CAM use. Design/subjects Analyses were based on women (Total N = 879; n = 479 lesbians) enrolled in the Epidemiologic STudy of HEalth Risk in Women (ESTHER) Project, a cross-sectional heart-disease risk-factor study. Settings/location Data were collected through convenience sampling of adult females in Pittsburgh, PA (2003–2006). Outcome measures Main outcome measures included lifetime and past 12-month CAM use, and types of CAM modalities used in the past 12 months. Results The prevalence of having ever used CAM was 49.8%, with 42% having reported CAM use within the past 12 months. Lesbians had greater odds of having ever used CAM (adjusted odds ratio [AOR] = 1.68 [95% confidence interval (CI): 1.23, 2.28]) and of having used CAM in the past 12 months (AOR = 1.44 [CI: 1.06, 1.97]) than heterosexuals. In multivariate analyses, correlates of lifetime and past 12-month CAM use included being lesbian, white, higher educated, and a large-city resident; experiencing perceived discrimination in a health care setting; and having a greater spirituality rating and a history of a diagnosed mental health disorder. Past 12-month CAM use was also associated with having a provider of usual health care. Among women who used CAM within the past 12 months, heterosexuals had significantly higher yoga participation rates than lesbians. Conclusions Sexual orientation is important in understanding lifetime and past 12-month CAM use. Because of the high prevalence of CAM use found in this study, medical practitioners should inquire about the CAM practices of female patients, particularly lesbians

  1. Relationships between 700 hPa height anomalies and 1 April snowpack accumulations in the western USA

    USGS Publications Warehouse

    McCabe, G.J.; Legates, D.R.

    1995-01-01

    Relationships between atmospheric circulation and the temporal and spatial distribution of snowpack accumulations in the western USA are examined. In general, above-average snowpack accumulations are associated with negative 700 hPa height anomalies over the eastern North Pacific Ocean and the western USA. These anomalies are indicative of anomalous cyclonic circulation, which produces an anomalous westerly flow of moist air from the eastern North Pacific Ocean into the western USA and increases winter precipitation and snowpack accumulations. Below-average snowpack accumulations at most of the snowcourse stations are associated with positive 700 hPa anomalies over the western USA. -from Authors

  2. VIEW OF SOUTH END OF TUNNEL UNDERNEATH PITTSBURGH & LAKE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF SOUTH END OF TUNNEL UNDERNEATH PITTSBURGH & LAKE ERIE RIGHT OF WAY. THE SIGN READS "ACCIDENTS JUST DON'T HAPPEN, THEY ARE CAUSED". - Pittsburgh Steel Company, Monessen Works, Donner Avenue, Monessen, Westmoreland County, PA

  3. Boiler & Tank Shop, north elevation. The Pittsburgh, Chartiers & ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Boiler & Tank Shop, north elevation. The Pittsburgh, Chartiers & Youghiogheny Railway (PC&Y) bridge is at far right. - Pittsburgh & Lake Erie Railroad, Locomotive Repair Shops, River Road at Chartiers Avenue, McKees Rocks, Allegheny County, PA

  4. Re-suspension of lead contaminated urban soil as a dominant source of atmospheric lead in Birmingham, Chicago, Detroit and Pittsburgh, USA

    NASA Astrophysics Data System (ADS)

    Laidlaw, Mark A. S.; Zahran, Sammy; Mielke, Howard W.; Taylor, Mark P.; Filippelli, Gabriel M.

    2012-03-01

    Soils in older areas of cities are highly contaminated by lead, due largely to past use of lead additives in gasoline, the use of lead in exterior paints, and industrial lead sources. Soils are not passive repositories and periodic re-suspension of fine lead contaminated soil dust particulates (or aerosols) may create seasonal variations of lead exposure for urban dwellers. Atmospheric soil and lead aerosol data from the Interagency Monitoring of Protected Visual Environments (IMPROVE) database were obtained for Pittsburgh (Pennsylvania), Detroit (Michigan), Chicago (Illinois), and Birmingham (Alabama), USA. In this study the temporal variations of atmospheric soil and lead aerosols in these four US cities were examined to determine whether re-suspended lead contaminated urban soil was the dominant source of atmospheric lead. Soil and lead-in-air concentrations were examined to ascertain whether lead aerosols follow seasonal patterns with highest concentrations during the summer and/or autumn. In addition, atmospheric soil and lead aerosol concentrations on weekends and Federal Government holidays were compared to weekdays to evaluate the possibility that automotive turbulence results in re-suspension of lead contaminated urban soil. The results show that the natural logs of atmospheric soil and lead aerosols were associated in Pittsburgh from April 2004 to July 2005 (R2 = 0.31, p < 0.01), Detroit from November 2003 to July 2005 (R2 = 0.49, p <0.01), Chicago from November 2003 to August 2005 (R2 = 0.32, p < 0.01), and Birmingham from May 2004 to December 2006 (R2 = 0.47, p < 0.01). Atmospheric soil and lead aerosols followed seasonal patterns with highest concentrations during the summer and/or autumn. Atmospheric soil and lead aerosols are 3.15 and 3.12 times higher, respectively, during weekdays than weekends and Federal Government holidays, suggesting that automotive traffic turbulence plays a significant role in re-suspension of contaminated roadside soils and

  5. 15. Photocopy of original drawing belonging to the Pittsburgh Department ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Photocopy of original drawing belonging to the Pittsburgh Department of Public Works, (n.d.). DRAWING NO. 2002: ORNAMENTAL IRON & BRONZE, LOCATION PLAN AND BRONZE TABLETS. - North Side Point Bridge, Spanning Allegheny River at Point of Pittsburgh, Pittsburgh, Allegheny County, PA

  6. 3. Photocopy of original drawing belonging to the Pittsburgh Department ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Photocopy of original drawing belonging to the Pittsburgh Department of Public Works, (n.d.). DRAWING NO. 1963: STRESS AND SECTION SHEET FOR 531' STEEL SPANS. - North Side Point Bridge, Spanning Allegheny River at Point of Pittsburgh, Pittsburgh, Allegheny County, PA

  7. 13. Photocopy of original drawing belonging to the Pittsburgh Department ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Photocopy of original drawing belonging to the Pittsburgh Department of Public Works, (n.d.). DRAWING NO. 2000: ORNAMENTAL IRON & BRONZE DETAILS, UPPER PART OF PORTALS. - North Side Point Bridge, Spanning Allegheny River at Point of Pittsburgh, Pittsburgh, Allegheny County, PA

  8. 11. Photocopy of original drawing belonging to the Pittsburgh Department ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Photocopy of original drawing belonging to the Pittsburgh Department of Public Works, (n.d.). DRAWING NO. 1998: ORNAMENTAL IRON & BRONZE DETAILS, LOWER PART OF PORTALS. - North Side Point Bridge, Spanning Allegheny River at Point of Pittsburgh, Pittsburgh, Allegheny County, PA

  9. 12. Photocopy of original drawing belonging to the Pittsburgh Department ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Photocopy of original drawing belonging to the Pittsburgh Department of Public Works, (n.d.). DRAWING NO. 1999: ORNAMENTAL IRON & BRONZE DETAILS, UPPER PART OF PORTALS. - North Side Point Bridge, Spanning Allegheny River at Point of Pittsburgh, Pittsburgh, Allegheny County, PA

  10. 10. Photocopy of original drawing belonging to the Pittsburgh Department ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Photocopy of original drawing belonging to the Pittsburgh Department of Public Works, (n.d.). DRAWING NO. 1997: ORNAMENTAL IRON & BRONZE, FRONT ELEVATION OF SOUTH PORTAL. - North Side Point Bridge, Spanning Allegheny River at Point of Pittsburgh, Pittsburgh, Allegheny County, PA

  11. 14. Photocopy of original drawing belonging to the Pittsburgh Department ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Photocopy of original drawing belonging to the Pittsburgh Department of Public Works, (n.d.). DRAWING NO. 2001: ORNAMENTAL IRON & BRONZE, REAR ELEVATION OF PORTALS AND DETAILS. - North Side Point Bridge, Spanning Allegheny River at Point of Pittsburgh, Pittsburgh, Allegheny County, PA

  12. 49 CFR 372.211 - Pittsburgh, PA.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... commerce, not under common control, management, or arrangement for a continuous carriage or shipment to or...) and (c) of this section, and (e) All of any municipality wholly surrounded, or so surrounded...

  13. Pittsburgh, Pennsylvania: Solar in Action (Brochure)

    SciTech Connect

    Not Available

    2011-10-01

    This brochure provides an overview of the challenges and successes of Pittsburgh, PA, a 2007 Solar America City awardee, on the path toward becoming a solar-powered community. Accomplishments, case studies, key lessons learned, and local resource information are given.

  14. 77 FR 47671 - TA-W-81,520, T-Mobile USA, Inc., Call Center, Allentown, PA; TA-W-81,520G, T-Mobile USA, Inc...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ... Employment and Training Administration TA-W-81,520, T-Mobile USA, Inc., Call Center, Allentown, PA; TA- W-81,520G, T-Mobile USA, Inc., Headquarters Office, Bellevue, WA; Amended Certification Regarding... to Apply for Worker Adjustment Assistance on July 11, 2012, applicable to workers of T-Mobile...

  15. Acid aerosols in the Pittsburgh Metropolitan area

    NASA Astrophysics Data System (ADS)

    McCurdy, Thomas; Zelenka, Michael P.; Lawrence, Philip M.; Houston, Robert M.; Burton, Robert

    This article presents data on ambient concentrations of selected acidic aerosols at four existing monitoring sites in the Pittsburgh PA metropolitan area. The data were collected by staff of the Allegheny County Health Department, Division of Air Quality during the summer and fall of 1993. The sampling protocol was focused on obtaining 24 h-average ammonia, ammonium, acidic sulfates, and particle strong acids data on a 2 to 3 day cycle. The data were obtained using Harvard University School of Public Health's "Short-HEADS" annular denuder sampling train. The Pittsburgh area is of interest because it is downwind of a major regional source of sulfur and nitrogen emissions from coal-burning power plants: the Ohio River Valley. The data presented here indicate that ground-level concentrations of acidic aerosols in Pittsburgh are highly correlated spatially and that many pollutants are higher on days when ground-level wind direction vectors indicate that wind is coming from the southwest rather than from the Pittsburgh source area itself. The monitoring site that is most upwind of the Pittsburgh source area - South Fayette - has particle strong acid levels about twice those of sites closer in to the Pittsburgh central business district.

  16. Immunology in Pittsburgh.

    PubMed

    Finn, Olivera J; Salter, Russell D

    2006-01-01

    The University of Pittsburgh School of Medicine has a long tradition of excellence in immunology research and training. Faculty, students, and postdoctoral fellows walk through hallways that are pictorial reminders of the days when Dr. Jonas Salk worked here to develop the polio vaccine, or when Dr. Niels Jerne chaired the Microbiology Department and worked on perfecting the Jerne Plaque Assay for antibody-producing cells. Colleagues and postdoctoral fellows of Professor Salk are still on the faculty of the University of Pittsburgh Medical School as are graduate students of Professor Jerne. A modern research building, the 17 story high Biomedical Science Tower, is a vivid reminder of the day when Dr. Thomas Starzl arrived in Pittsburgh and started building the most prominent solid-organ-transplant program in the world. The immunology research that developed around the problem of graft rejection and tolerance induction trained numerous outstanding students and fellows. Almost 20 yr ago, the University of Pittsburgh founded the University of Pittsburgh Cancer Institute (UPCI) with the renowned immunologist Dr. Ronald Herberman at its helm. This started a number of new research initiatives in cancer immunology and immunotherapy. A large number of outstanding young investigators, as well as several well-established tumor immunologists, were recruited to Pittsburgh at that time.

  17. Pittsburgh School Gets Energized.

    ERIC Educational Resources Information Center

    Hill, Willliam W.

    2002-01-01

    Describes a project designed to create an energy efficient high school in the diocese of Pittsburgh. The project will save over $850,000 in energy, operations, and maintenance costs over fifteen years. The design improves the physical premises as well by adding windows and eliminating fluorescent lighting. Offers tips for developing similar…

  18. Our Pittsburgh Constellation

    NASA Astrophysics Data System (ADS)

    Turnshek, Diane

    2015-08-01

    Riding on the Pittsburgh mayor’s keen interest in astronomy and the ongoing change of 40,000 city lights from mercury and sodium vapor to shielded LEDs, we organized a series of city-wide celestial art projects to bring attention to the skies over Pittsburgh. Light pollution public talks were held at the University of Pittsburgh’s Allegheny Observatory and other colleges. Earth Hour celebrations kicked off an intensive year of astronomy outreach in the city. Lights went out on March 28, 2015 from 8:30 to 9:30 pm in over fifty buildings downtown and in Oakland (the “Eds and Meds” center, where many Pittsburgh universities and hospitals are located). Our art contest was announced at the De-Light Pittsburgh celebration at the Carnegie Science Center during Astronomy Weekend. “Our Pittsburgh Constellation” is an interactive Google map of all things astronomical in the city. Different colored stars mark locations of planetariums, star parties, classes, observatories, lecture series, museums, telescope manufacturers and participating art galleries. Contest entrants submitted artwork depicting their vision of the constellation figure that incorporates and connects all the “stars” in our custom city map. Throughout the year, over a dozen artists ran workshops on painting star clusters, galaxies, nebulae, comets, planets and aurorae with discussions of light pollution solutions and scientific explanations of what the patrons were painting, including demonstrations with emission tubes and diffraction grating glasses. We will display the celestial art created in this International Year of Light at an art gallery as part of the City’s Department of Innovation & Performance March 2016 Earth Hour gala. We are thankful for the Astronomical Footprint grant from the Heinz Endowments, which allowed us to bring the worlds of science and art together to enact social change.

  19. 75 FR 10505 - FCI USA, LLC, Including On-Site Leased Workers From Manpower, Inc., Mount Union, PA; Amended...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-08

    ... Employment and Training Administration FCI USA, LLC, Including On-Site Leased Workers From Manpower, Inc... January 22, 2010, applicable to workers of FCI USA, LLC, including on-site leased workers from Manpower... issued as follows: All workers of FCI USA, LLC, including on-site leased workers from Manpower, Inc...

  20. 75 FR 10822 - FCI USA, LLC Including On-Site Leased Workers From Manpower, Inc.; Mount Union, PA; Amended...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ... Employment and Training Administration FCI USA, LLC Including On-Site Leased Workers From Manpower, Inc... January 22, 2010, applicable to workers of FCI USA, LLC, including on-site leased workers from Manpower... issued as follows: All workers of FCI USA, LLC, including on-site leased workers from Manpower, Inc...

  1. Nutrition Education--1973. Part 7--School Nutrition Education Programs. Hearings Held Pittsburgh, Pa., May 25, 1973. Hearings Before the Select Committee on Nutrition and Human Needs of the United States Senate, Ninety-third Congress, First Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Select Committee on Nutrition and Human Needs.

    The following witnesses testified before these hearings of the Select Committee on Nutrition and Human Needs: Mrs. G. Marsh, area consultant, Division of Food and Nutrition Services, Pennsylvania Department of Education; Mrs. G. Chegwidden, director, School Food Service, Franklin Regional School District, Murrysville, Pa.; Mr. S. Lympany, senior…

  2. Public health assessment addendum for Letterkenny Army Depot, USA Letterkenny Southeast Area, Chambersburg, Franklin County, Pennsylvania, Region 3. CERCLIS No. PA6213820503 and USA Letterkenny, Property Disposal Office Area, Chambersburg, Franklin County, Pennsylvania. CERCLIS No. PA2210090054. Final report

    SciTech Connect

    Not Available

    1993-05-25

    The Letterkenny Army Depot (Letterkenny) is five miles north of Chambersburg, in Franklin County, Pennsylvania. The US Army Depot consists of two National Priorities List (NPL) sites: USA Letterkenny Southeast Area (hereafter referred to as the SE Area) and USA Letterkenny - Property Disposal Office Area (hereafter referred to as the PDO Area). A public health assessment of those combined sites was released by the Agency for Toxic Substances and Disease Registry on September 30, 1988 (Appendix 1). The previous public health assessment combined discussion of both NPL sites due to similar contaminants and pathways. Since the release of the previous public health assessment, new environmental, community health concerns, and health outcome data have become available, warranting this addendum.

  3. The Pittsburgh Sleep Diary

    NASA Technical Reports Server (NTRS)

    Monk, T. H.; Reynolds CF, 3. d.; Kupfer, D. J.; Buysse, D. J.; Coble, P. A.; Hayes, A. J.; Machen, M. A.; Petrie, S. R.; Ritenour, A. M.

    1994-01-01

    Increasingly, there is a need in both research and clinical practice to document and quantify sleep and waking behaviors in a comprehensive manner. The Pittsburgh Sleep Diary (PghSD) is an instrument with separate components to be completed at bedtime and waketime. Bedtime components relate to the events of the day preceding the sleep, waketime components to the sleep period just completed. Two-week PghSD data is presented from 234 different subjects, comprising 96 healthy young middle-aged controls, 37 older men, 44 older women, 29 young adult controls and 28 sleep disorders patients in order to demonstrate the usefulness, validity and reliability of various measures from the instrument. Comparisons are made with polysomnographic and actigraphic sleep measures, as well as personality and circadian type questionnaires. The instrument was shown to have sensitivity in detecting differences due to weekends, age, gender, personality and circadian type, and validity in agreeing with actigraphic estimates of sleep timing and quality. Over a 12-31 month delay, PghSD measures of both sleep timing and sleep quality showed correlations between 0.56 and 0.81 (n = 39, P < 0.001).

  4. The Pittsburgh Sleep Diary

    NASA Technical Reports Server (NTRS)

    Monk, T. H.; Reynolds CF, 3. d.; Kupfer, D. J.; Buysse, D. J.; Coble, P. A.; Hayes, A. J.; Machen, M. A.; Petrie, S. R.; Ritenour, A. M.

    1994-01-01

    Increasingly, there is a need in both research and clinical practice to document and quantify sleep and waking behaviors in a comprehensive manner. The Pittsburgh Sleep Diary (PghSD) is an instrument with separate components to be completed at bedtime and waketime. Bedtime components relate to the events of the day preceding the sleep, waketime components to the sleep period just completed. Two-week PghSD data is presented from 234 different subjects, comprising 96 healthy young middle-aged controls, 37 older men, 44 older women, 29 young adult controls and 28 sleep disorders patients in order to demonstrate the usefulness, validity and reliability of various measures from the instrument. Comparisons are made with polysomnographic and actigraphic sleep measures, as well as personality and circadian type questionnaires. The instrument was shown to have sensitivity in detecting differences due to weekends, age, gender, personality and circadian type, and validity in agreeing with actigraphic estimates of sleep timing and quality. Over a 12-31 month delay, PghSD measures of both sleep timing and sleep quality showed correlations between 0.56 and 0.81 (n = 39, P < 0.001).

  5. 76 FR 47993 - Safety Zone; Allegheny River; Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-08

    ... safety zone on the Allegheny River from mile marker 5.7 to mile marker 5.9 (the parking area on either... marker 5.9 (the parking area on either side of the 13th Street boat ramp), extending 300 feet from the... parking area on either side of the 13th Street boat ramp), extending 300 feet from the right descending...

  6. EnviroAtlas - Pittsburgh, PA - Greenspace Proximity Gradient

    EPA Pesticide Factsheets

    In any given 1-square meter point in this EnviroAtlas dataset, the value shown gives the percentage of square meters of greenspace within 1/4 square kilometer centered over the given point. Green space is defined as Trees & Forest and Grass & Herbaceous. Water is shown as -99999 in this dataset to distinguish it from land areas with very low green space. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

  7. EnviroAtlas - Pittsburgh, PA - Land Cover by Block Group

    EPA Pesticide Factsheets

    This EnviroAtlas dataset describes the percentage of each block group that is classified as impervious, forest, and green space. Forest is combination of trees and forest and woody wetlands. Green space is a combination of trees and forest, grass and herbaceous, agriculture, woody wetlands, and emergent wetlands. Wetlands includes both Woody and Emergent Wetlands. This dataset also includes the area per capita for each block group for impervious, forest, and green space land cover. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

  8. 76 FR 27892 - Special Local Regulation; Allegheny River, Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ... from the hazards of marine traffic. Entry into, movement within, and departure from this Coast Guard... hazards imposed by marine traffic. The date of the Venture Outdoors Festival is tied to numerous other... safeguard participants of the Venture Outdoors Festival from the hazards of marine traffic. Discussion...

  9. EnviroAtlas - Pittsburgh, PA - Proximity to Parks

    EPA Pesticide Factsheets

    This EnviroAtlas dataset shows the approximate walking distance from a park entrance at any given location within the EnviroAtlas community boundary. The zones are estimated in 1/4 km intervals up to 1km then in 1km intervals up to 5km. Park entrances were included in this analysis if they were within 5km of the community boundary. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

  10. EnviroAtlas - Pittsburgh, PA - Park Access by Block Group

    EPA Pesticide Factsheets

    This EnviroAtlas dataset shows the block group population that is within and beyond an easy walking distance (500m) of a park entrance. Park entrances were included in this analysis if they were within 5km of the EnviroAtlas community boundary. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

  11. Pittsburgh Adapts to Changing Times.

    ERIC Educational Resources Information Center

    States, Deidre

    1985-01-01

    The Samuel F. B. Morse School, built in 1874 and closed in 1980, is a historic landmark in Pittsburgh, Pennsylvania. Now the building serves as low-income housing for 70 elderly tenants and is praised as being an imaginative and creative use of an old school structure. (MLF)

  12. Pittsburgh Tuskegee Prostate Training Program

    DTIC Science & Technology

    2014-05-01

    education.   15 . SUBJECT TERMS prostate cancer, health disparities, training, education, tumor biology 16. SECURITY CLASSIFICATION OF: 17...Year (2013) December 2012 – March 2013, Tuskegee University sophomore trainees will be selected as “Prostate Cancer Scholars” for summer internship... sophomore trainees will be selected as “Prostate Cancer Scholars” for summer internship at the University of Pittsburgh. This is being reported on

  13. Environmental Survey preliminary report, Pittsburgh Energy Technology Center, Pittsburgh, Pennsylvania

    SciTech Connect

    Not Available

    1988-09-01

    This report presents the preliminary findings from the first phase of the Environmental Survey of the US Department of Energy (DOE) Pittsburgh Energy Technology Center (PETC) conducted December 7--11, 1987. The Survey is being conducted by an interdisciplinary team of environmental specialists, led and managed by the Office of Environment, Safety and Health's Office of Environmental Audit. Individual team specialists are outside experts being supplied by a private contractor. The objective of the Survey is to identify environmental problems and areas of environmental risk associated with PETC. The Survey covers all environmental media and all areas of environmental regulation. It is being performed in accordance with the DOE Environmental Survey Manual. This phase of the Survey involves the review of existing site environmental data, observations of the operations carried on at PETC, and interviews with site personnel. The Survey team developed a Sampling and Analysis (S A) Plan to assist in further assessing certain environmental problems identified during its on-site Survey activities at PETC. The S A Plan will be executed by the Oak Ridge National Laboratory (ORNL). When completed, the Plan's results will be incorporated into the PETC Survey findings for inclusion into the Environmental Survey Summary Report. 64 refs., 23 figs., 29 tabs.

  14. 77 FR 77016 - Foreign-Trade Zone 33 - Pittsburgh, Pennsylvania Notification of Proposed Export Production...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-31

    ... Export Production Activity Tsudis Chocolate Company (Chocolate Confectionery Bars) Pittsburgh, PA Tsudis Chocolate Company (Tsudis), an operator of FTZ 33, submitted a notification of proposed export production... production of chocolate confectionery bars for export (no shipments for U.S. consumption would occur). For...

  15. Pittsburgh Registry of Infant Multiplets (PRIM).

    PubMed

    Strassberg, Melissa; Peters, Katherine; Marazita, Mary; Ganger, Jennifer; Watt-Morse, Margaret; Murrelle, Lenn; Tarter, Ralph; Vanyukov, Michael

    2002-10-01

    This paper describes the Pittsburgh Registry of Infant Multiplets (PRIM; Pittsburgh, Pennsylvania), the results of pilot research conducted in this registry, and the plans for future studies. The main focus of the registry is on psychological development and the risk for behavioral disorders. Particularly, characteristics associated with antisociality and the risk for substance use disorders (e.g., aggressivity, hyperactivity/impulsivity), as well as language development and other traits (e.g., dental health) are among the research targets.

  16. Defending the Pittsburgh Waterways Against Catastrophic Disruption

    DTIC Science & Technology

    2012-06-01

    economy is dependent upon coal to produce low cost energy and to manufacture steel. The Three Rivers region of Pittsburgh, Pennsylvania—consisting of...find new delivery routes. The Three Rivers region of Pittsburgh, Pennsylvania sits on one of the richest coal reserves in the U.S.. The Monongahela...navigable waters in the Eastern United States (Figure 1). Coal and other commodities are transported into and out of the region via barge on this river

  17. The Community Education Project: Pittsburgh, Pennsylvania.

    ERIC Educational Resources Information Center

    Beachler, Judith Anne

    This paper outlines aspects of a community education project, which involved the Community College of Allegheny County (CCAC) and other educational institutions and community service agencies in Pittsburgh in the provision of adult and continuing education and adult and family recreation programs. After section I provides background information on…

  18. Pittsburgh Building "Nation" of 9th Graders

    ERIC Educational Resources Information Center

    Gewertz, Catherine

    2007-01-01

    Bitter experience has shown Pittsburgh, Pennsylvania, that if students are going to leave school, they are most likely to do it between the 8th and 9th grades. To combat that problem, the school district has launched a full-on campaign to get its rising freshmen into high school and keep them there. Two weeks before school opened, the district…

  19. The Community Education Project: Pittsburgh, Pennsylvania.

    ERIC Educational Resources Information Center

    Beachler, Judith Anne

    This paper outlines aspects of a community education project, which involved the Community College of Allegheny County (CCAC) and other educational institutions and community service agencies in Pittsburgh in the provision of adult and continuing education and adult and family recreation programs. After section I provides background information on…

  20. Field strategies for the calibration and validation of high-resolution forest carbon maps: Scaling from plots to a three state region MD, DE, & PA, USA.

    NASA Astrophysics Data System (ADS)

    Dolan, K. A.; Huang, W.; Johnson, K. D.; Birdsey, R.; Finley, A. O.; Dubayah, R.; Hurtt, G. C.

    2016-12-01

    In 2010 Congress directed NASA to initiate research towards the development of Carbon Monitoring Systems (CMS). In response, our team has worked to develop a robust, replicable framework to quantify and map aboveground forest biomass at high spatial resolutions. Crucial to this framework has been the collection of field-based estimates of aboveground tree biomass, combined with remotely detected canopy and structural attributes, for calibration and validation. Here we evaluate the field- based calibration and validation strategies within this carbon monitoring framework and discuss the implications on local to national monitoring systems. Through project development, the domain of this research has expanded from two counties in MD (2,181 km2), to the entire state of MD (32,133 km2), and most recently the tri-state region of MD, PA, and DE (157,868 km2) and covers forests in four major USDA ecological providences. While there are approximately 1000 Forest Inventory and Analysis (FIA) plots distributed across the state of MD, 60% fell in areas considered non-forest or had conditions that precluded them from being measured in the last forest inventory. Across the two pilot counties, where population and landuse competition is high, that proportion rose to 70% Thus, during the initial phases of this project 850 independent field plots were established for model calibration following a random stratified design to insure the adequate representation of height and vegetation classes found across the state, while FIA data were used as an independent data source for validation. As the project expanded to cover the larger spatial tri-state domain, the strategy was flipped to base calibration on more than 3,300 measured FIA plots, as they provide a standardized, consistent and available data source across the nation. An additional 350 stratified random plots were deployed in the Northern Mixed forests of PA and the Coastal Plains forests of DE for validation.

  1. NARSTO EPA SS PITTSBURGH GAS PM PROPERTY DATA

    Atmospheric Science Data Center

    2014-04-25

    NARSTO EPA SS PITTSBURGH GAS PM PROPERTY DATA Project Title:  NARSTO Discipline:  Tropospheric Chemistry Field Campaigns Aerosols Level:  L2 ... Data Guide Documents:  Pittsburgh Gas PM Property Guide Pittsburgh Project Plan  (PDF) ...

  2. The Pittsburgh Promise: A Community's Commitment to Its Young People

    ERIC Educational Resources Information Center

    Ghubril, Saleem

    2013-01-01

    The nonprofit community-based organization Pittsburgh Promise aims to help revitalize Pittsburgh and its public school system by offering college scholarships to any Pittsburgh Public School graduate who meets the academic requirements. Executive director Saleem Ghubril spoke with "Voices in Urban Education" guest editor Jacob Mishook…

  3. 78 FR 5137 - Safety Zone; Monongahela River, Charleroi, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-24

    ... established with minimal notice when ideal work conditions are identified. The Captain of the Port Pittsburgh... of guard wall upstream of Lock and Dam 4 in Charleroi, PA. This event poses hazardous conditions on... forecasts will be used to determine the most suitable conditions for demolition operations. Advanced...

  4. Airborne gamma-ray spectrometer and magnetometer survey, Cleveland Quadrangle (PA,OH), Erie Quadrangle (PA), Warren Quadrangle (PA), and Pittsburgh Quadrangle (PA). Volume 1. Final report

    SciTech Connect

    Not Available

    1982-01-01

    Data were collected by a helicopter equipped with a gamma-ray spectrometer with a large crystal volume, and with a high sensitivity proton precession magnetometer. The radiometric system was calibrated at the Walker Field Calibration pads and the Lake Mead Dynamic Test Range. Data quality was ensured during the survey by daily test flights and equipment checks. Radiometric data were corrected for live time, aircraft and equipment background, cosmic background, atmospheric radon, Compton scatter, and altitude dependence. The corrected data were statistically evaluated, plotted, and contoured to produce anomaly maps based on the radiometric response of individual geological units. The anomalies were interpreted and an interpretation map produced. Volume I contains a description of the systems used in the survey, a discussion of the calibration of the systems, the data collection procedures, the data processing procedures, the data presentation, the interpretation rationale, and the interpretation methodology.

  5. Interprofessional Forum and Competition, University of Pittsburgh.

    PubMed

    Meyer, Susan M

    2010-01-01

    Initiated in fall 2008, the annual Interprofessional Forum introduces the theme of interprofessional collaboration to an audience of approximately 600 first-year students drawn from the University of Pittsburgh Schools of the Health Sciences (dental medicine, health and rehabilitation sciences, medicine, nursing, pharmacy, and public health). The required 2-hour program targets the following learning outcomes and goals: Illustrate the areas of expertise of various health professionals who provide patient care; Explore the importance of teamwork among health care providers from the patient's perspective, as well as to provide "complete" care and optimized patient functionality and quality of life; and Describe how health professions education programs are addressing interprofessional team skills and practice models.

  6. Pittsburgh and the Arts or How My Eye Was Formed.

    ERIC Educational Resources Information Center

    Roschwalb, Susanne A.

    The way the author's experiences of the city of Pittsburgh (Pennsylvania) shaped her visual literacy are explored. Along with the imagery of the steel mills, she experienced some artistic opportunities that helped shape the foundation of her life in art. Although no American city was as extensively industrialized as Pittsburgh, it was the artistic…

  7. Photographic copy of construction drawing, dated November 10, 1930, Pittsburgh ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of construction drawing, dated November 10, 1930, Pittsburgh Des Moines Steel Company, Pittsburgh, Pennsylvania, in possession of Selfridge Base Museum, Mt. Clemens, Michigan. SELFRIDGE FIELD ERECTION DRAWING, CONTRACT NO. 1895, SHEET NO. 15 - Selfridge Field, Building No. 7200, South of George Avenue between Walnut & Beach Streets, Mount Clemens, Macomb County, MI

  8. University-Urban Interface Program. Pittsburgh Goals: Some Issues.

    ERIC Educational Resources Information Center

    Nehnevajsa, Jiri

    The Pittsburgh Goals Study about which this speech centers is SO 004 019. Issues identified by the leaders questioned which seem particularly crucial for the next five years in the development of Pittsburgh are: pollution control; public welfare system; drug problem; health services; low cost housing; rapid transit. Two more issues, Metropolitan…

  9. Value-Added Models for the Pittsburgh Public Schools

    ERIC Educational Resources Information Center

    Johnson, Matthew; Lipscomb, Stephen; Gill, Brian; Booker, Kevin; Bruch, Julie

    2012-01-01

    At the request of Pittsburgh Public Schools (PPS) and the Pittsburgh Federation of Teachers (PFT), Mathematica has developed value-added models (VAMs) that aim to estimate the contributions of individual teachers, teams of teachers, and schools to the achievement growth of their students. The authors' work in estimating value-added in Pittsburgh…

  10. 7. PORTAL ELEVATION, LOOKING SE. SINGLE BRIDGE IS PITTSBURGH, FORT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. PORTAL ELEVATION, LOOKING SE. SINGLE BRIDGE IS PITTSBURGH, FORT WAYNE & CHICAGO RAILWAY; PAIR OF BRIDGES ARE ABANDONED LAKE SHORE AND MICHIGAN SOUTHERN RAILROAD (HAER No. IL-161). - Pittsburgh, Fort Wayne & Chicago Railway, Calumet River Bridge, Spanning Calumet River, east of Chicago Skyway (I-90), Chicago, Cook County, IL

  11. PORTAL ELEVATION, LOOKING SE. SINGLE BRIDGE IS PITTSBURGH, FORT WAYNE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PORTAL ELEVATION, LOOKING SE. SINGLE BRIDGE IS PITTSBURGH, FORT WAYNE & CHICAGO RAILWAY; PAIR OF BRIDGES ARE ABANDONED LAKE SHORE AND MICHIGAN SOUTHERN RAILROAD (HAER No. IL-161). - Pittsburgh, Fort Wayne & Chicago Railway, Calumet River Bridge, Spanning Calumet River, east of Chicago Skyway (I-90), Chicago, Cook County, IL

  12. Pittsburgh and the Arts or How My Eye Was Formed.

    ERIC Educational Resources Information Center

    Roschwalb, Susanne A.

    The way the author's experiences of the city of Pittsburgh (Pennsylvania) shaped her visual literacy are explored. Along with the imagery of the steel mills, she experienced some artistic opportunities that helped shape the foundation of her life in art. Although no American city was as extensively industrialized as Pittsburgh, it was the artistic…

  13. 75 FR 24961 - Pittsburgh Area Maritime Security Committee; Vacancies

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-06

    ... SECURITY Coast Guard Pittsburgh Area Maritime Security Committee; Vacancies AGENCY: Coast Guard, DHS... the Pittsburgh Area Maritime Security Committee (AMSC) to submit their application for membership, to... Security Act (MTSA) of 2002 (Pub. L. 107-295) added section 70112 to Title 46 of the U.S. Code,...

  14. Water resources of the Pittsburgh area, Pennsylvania

    USGS Publications Warehouse

    Noecker, Max; Greenman, D.W.; Beamer, N.H.

    1954-01-01

    The per capita use of water in the Pittsburgh area in 1951 was 2, 000 gallons per day fgpd) or twice the per capita use in Pennsylvania as a whole. An average of about 3, 040 million gallons of water was withdrawn from the streams and from the ground each day. Of this amount, nearly 190 million gallons per day (mgd), or 6 percent, was for domestic public water supply. Industry, including public utilities generating steam for electric energy, used approximately 2, 900 mgd, of which about 42 mgd was purchased from public supply sources. In spite of this tremendous demand for water, a sufficient quantity was available to satisfy the needs of the area without serious difficulty. Acid mine drainage presents the greatest single pollution problem in the Pittsburgh area at the present time (1953) because no practical means has been found for its control. The waters of several of the rivers are strongly acid for this reason. Of the three major rivers in the area, Monongahela River waters have the greatest acid concentration and Allegheny River waters the least. Untreated domestic and industrial wastes are additional sources of stream pollution in the area. Much of the water is hard and corrosive, and occasionally has objectionable color, odor, and taste. The treatment used by public water-supply systems using river water is adequate at all times for removal of water-borne causes of disease. Attention is being concentrated on improving the quality of present supplies rather than developing new supplies from upstream tributaries. Present supplies are being improved by providing treatment facilities for disposal of wastes,, by reduction of acid mine drainage discharged into the streams, and by providing storage to augment low flows. The underground water resources are vitally important to the area. The use of ground water in the Pittsburgh area has doubled in the past two decades and in 1951 more ground water was used in Allegheny County than in any other county in

  15. 78 FR 22285 - Notice of Inventory Completion: Carnegie Museum of Natural History, Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ... from Emerson Cemetery, in Hancock County, ME. This notice is published as part of the National Park... minimum, one individual were removed from the Emerson Cemetery near Lake Alamoosook, in Orland, Hancock... tribes desire to maintain ancestral burials and cemeteries undisturbed. Orland, ME, is within...

  16. Einstein's lecture in Pittsburgh, PA, December 1934: A note on further visual documentation

    NASA Astrophysics Data System (ADS)

    Topper, David; Vincent, Dwight

    2016-05-01

    Two newly discovered photographs of Einstein's 1934 lecture derivation of the energy-mass equivalence, popularly written as E = M c 2 , are analyzed for clues as to how the only visually documented blackboard lecture of his famous equation progressed. A previous analysis is supplemented with the new information.

  17. EnviroAtlas - Pittsburgh, PA - Estimated Intersection Density of Walkable Roads

    EPA Pesticide Factsheets

    This EnviroAtlas dataset estimates the intersection density of walkable roads within a 750 meter radius of any given 10 meter pixel in the community. Intersections are defined as any point where 3 or more roads meet and density is calculated using kernel density, where closer intersections are weighted higher than further intersections. Intersection density is highly correlated with walking for transportation. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

  18. European Security: Towards 2000 Held in Pittsburgh, PA on 25-26 September 1991

    DTIC Science & Technology

    1991-09-26

    about the future direction of the European security system. This is hardly surprising. Coming as they did at the end of a period in which, as Raymond...security and stability? What role should existing institutions play in future European security arrangements? How can strategy be designed when there is no...States in devising and maintaining a post Cold War security system in Europe? What is the future role of the United States in European security

  19. POLLUTION PREVENTION OPPORTUNITY ASSESSMENT - U.S. POSTAL SERVICE POST OFFICES, PITTSBURGH, PA AREA

    EPA Science Inventory

    The United States Postal Service (USPS) in cooperation with EPA’s National Risk Management Research Laboratory (NRMRL) is engaged in an effort to integrate waste prevention and recycling activities into the waste management programs at Postal facilities. This report describ...

  20. EnviroAtlas - Pittsburgh, PA - Estimated Percent Green Space Along Walkable Roads

    EPA Pesticide Factsheets

    This EnviroAtlas dataset estimates green space along walkable roads. Green space within 25 meters of the road centerline is included and the percentage is based on the total area between street intersections. Green space provides valuable benefits to neighborhood residents and walkers by providing shade, improved aesthetics, and outdoor gathering spaces. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets ).

  1. 75 FR 38146 - Pittsburgh Coatings, Inc., Ambridge, PA; Notice of Revised Determination on Reconsideration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-01

    ..., Pennsylvania, who are engaged in employment related to the production of coated and painted structural steel... Register on May 20, 2010 (75 FR 28301). The workers were engaged in employment related to the production of painted and coated structural steel. The negative determination was based on the Department's...

  2. EnviroAtlas - Pittsburgh, PA - Residents with Potential Window Views of Trees by Block Group

    EPA Pesticide Factsheets

    This EnviroAtlas dataset shows the total block group population and the percentage of the block group population that has little access to potential window views of trees at home. Having little potential access to window views of trees is defined as having no trees & forest land cover within 50 meters. The window views are considered potential because the procedure does not account for presence or directionality of windows in one's home. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

  3. POLLUTION PREVENTION OPPORTUNITY ASSESSMENT - U.S. POSTAL SERVICE POST OFFICES, PITTSBURGH, PA AREA

    EPA Science Inventory

    The United States Postal Service (USPS) in cooperation with EPA’s National Risk Management Research Laboratory (NRMRL) is engaged in an effort to integrate waste prevention and recycling activities into the waste management programs at Postal facilities. This report describ...

  4. Best Practices Case Study: S&A Homes, East Liberty, PIttsburgh, PA

    SciTech Connect

    2010-12-01

    S&A Homes worked with Building America's IBACOS and architects Pfaffmann & Associates and Moss Associates to design energy-efficient homes for urban in-fill lots. This is a new market for S&A Homes, which builds over 500 homes a year using suburban designs.

  5. MFG-IRAP University of Pittsburgh.

    PubMed

    Baragi, V M

    1998-07-01

    The University of Pittsburgh is developing an MFG-IRAP gene therapy for the potential treatment of arthritis. Clinical studies have commenced, including one trial in arthritis patients [225365]. A retrovirus (MFG-IRAP) is used in the ex vivo transfer of a cDNA encoding the human interleukin-1 receptor antagonist (IL-1ra). The therapy is being tested in post-menopausal women, and involves the removal of some of their synovium, which is then transfected with the IRAP gene and reimplanted into the joint. The production of IL-1, 6, 8 and PGE2 is monitored [188197]. In the first clinical trial, a 68-year old woman received cultured synovial cells, transfected with the gene, in two knuckles. Two other knuckles received normal cells and acted as a control. The therapy was well-tolerated and successful transfer and expression of the therapeutic gene were detected. Three further post-menopausal women less than 75 years old are undergoing treatment and nine will be recruited all together [233384]. The initial studies were sponsored by Procter & Gamble [156779]. In rabbits, expression of IL-1ra in the lavage fluid of knees was evident for 4 to 6 weeks following ex vivo introduction of the gene into the synovial lining by the retrovirus construct. Levels were sufficient to offer protection in the inflammatory antigen-induced arthritis model [248952].

  6. City of Pittsburgh 2012 Technical Assistance Project Documents

    EPA Pesticide Factsheets

    Each report describes a design for a section of the City of Pittsburgh that was chosen in partnership with 3 Rivers Wet Wet Weather to address stormwater management and provide other green infrastructure benefits.

  7. 11. SOUTHWEST ELEVATION, SHOT FROM ADJACENT SCRAP YARD. Pittsburgh, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. SOUTHWEST ELEVATION, SHOT FROM ADJACENT SCRAP YARD. - Pittsburgh, Fort Wayne & Chicago Railway, Calumet River Bridge, Spanning Calumet River, east of Chicago Skyway (I-90), Chicago, Cook County, IL

  8. EPA Brownfields Grants will help revitalize Pittsburgh properties

    EPA Pesticide Factsheets

    PHILADELPHIA (Aug. 24, 2015) - The U.S. Environmental Protection Agency today announced the award of $400,000 in brownfields grants to Pittsburgh's North Side Industrial Development Company (NSIDC). The funding will be used to assess abandone

  9. Looking at the Right Data in the Right Way: Pittsburgh Public Schools

    ERIC Educational Resources Information Center

    Lavorini, Peter

    2013-01-01

    The Pittsburgh Promise is a nonprofit organization that grants college scholarships to all Pittsburgh Public Schools students meeting the academic requirements. Thanks to the Pittsburgh Promise, the children of Pittsburgh have an opportunity that few other children in the country do: to attend college without the additional, often insurmountable…

  10. POLLUTION PREVENTION OPPORTUNITY ASSESSMENT UNITED STATES ARMY CORPS OF ENGINEERS PITTSBURGH ENGINEER WAREHOUSE AND REPAIR STATION AND EMSWORTH LOCKS AND DAMS PITTSBURGH, PENNSYLVANIA

    EPA Science Inventory

    This report summarizes work conducted at the United States Army Corps of Engineers (USACE) Pittsburgh Engineering Warehouse and Repair Station (PEWARS) and Emsworth Locks and Dams in Pittsburgh, Pennsylvania under the U.S. Environmental Protection Agency's (EPA's) Waste Reduction...

  11. POLLUTION PREVENTION OPPORTUNITY ASSESSMENT UNITED STATES ARMY CORPS OF ENGINEERS PITTSBURGH ENGINEER WAREHOUSE AND REPAIR STATION AND EMSWORTH LOCKS AND DAMS PITTSBURGH, PENNSYLVANIA

    EPA Science Inventory

    This report summarizes work conducted at the United States Army Corps of Engineers (USACE) Pittsburgh Engineering Warehouse and Repair Station (PEWARS) and Emsworth Locks and Dams in Pittsburgh, Pennsylvania under the U.S. Environmental Protection Agency's (EPA's) Waste Reduction...

  12. A Heat Vulnerability Index and Adaptation Solutions for Pittsburgh, Pennsylvania.

    PubMed

    Bradford, Kathryn; Abrahams, Leslie; Hegglin, Miriam; Klima, Kelly

    2015-10-06

    With increasing evidence of global warming, many cities have focused attention on response plans to address their populations' vulnerabilities. Despite expected increased frequency and intensity of heat waves, the health impacts of such events in urban areas can be minimized with careful policy and economic investments. We focus on Pittsburgh, Pennsylvania and ask two questions. First, what are the top factors contributing to heat vulnerability and how do these characteristics manifest geospatially throughout Pittsburgh? Second, assuming the City wishes to deploy additional cooling centers, what placement will optimally address the vulnerability of the at risk populations? We use national census data, ArcGIS geospatial modeling, and statistical analysis to determine a range of heat vulnerability indices and optimal cooling center placement. We find that while different studies use different data and statistical calculations, all methods tested locate additional cooling centers at the confluence of the three rivers (Downtown), the northeast side of Pittsburgh (Shadyside/Highland Park), and the southeast side of Pittsburgh (Squirrel Hill). This suggests that for Pittsburgh, a researcher could apply the same factor analysis procedure to compare data sets for different locations and times; factor analyses for heat vulnerability are more robust than previously thought.

  13. A Heat Vulnerability Index and Adaptation Solutions for Pittsburgh, Pennsylvania

    NASA Astrophysics Data System (ADS)

    Klima, K.; Abrahams, L.; Bradford, K.; Hegglin, M.

    2015-12-01

    With increasing evidence of global warming, many cities have focused attention on response plans to address their populations' vulnerabilities. Despite expected increased frequency and intensity of heat waves, the health impacts of such events in urban areas can be minimized with careful policy and economic investments. We focus on Pittsburgh, Pennsylvania and ask two questions. First, what are the top factors contributing to heat vulnerability and how do these characteristics manifest geospatially throughout Pittsburgh? Second, assuming the City wishes to deploy additional cooling centers, what placement will optimally address the vulnerability of the at risk populations? We use national census data, ArcGIS geospatial modeling, and statistical analysis to determine a range of heat vulnerability indices and optimal cooling center placement. We find that while different studies use different data and statistical calculations, all methods tested locate additional cooling centers at the confluence of the three rivers (Downtown), the northeast side of Pittsburgh (Shadyside/ Highland Park), and the southeast side of Pittsburgh (Squirrel Hill). This suggests that for Pittsburgh, a researcher could apply the same factor analysis procedure to compare datasets for different locations and times; factor analyses for heat vulnerability are more robust than previously thought.

  14. Preparing for Local Adaptation: Understanding Flood Risk Perceptions in Pittsburgh

    NASA Astrophysics Data System (ADS)

    Klima, K.; Wong-Parodi, G.

    2015-12-01

    The City of Pittsburgh experiences numerous floods every year. Aging and insufficient infrastructure contribute to flash floods and to over 20 billion gallons of combined sewer overflows annually, contaminating Pittsburgh's streets, basements, and waterways. Climate change is expected to further exacerbate this problem by causing more intense and more frequent extreme precipitation events in Western Pennsylvania. For a stormwater adaptation plan to be implemented effectively, the City will need informed public support. One way to achieve public understanding and support is through effective communication of the risks, benefits, and uncertainties of local flooding hazards and adaptation methods. In order to develop these communications effectively, the city and its partners will need to know what knowledge and attitudes the residents of Pittsburgh already hold about flood risks. Here we seek to (1) identify Pittsburgh residents' knowledge level, risk perception and attitudes towards flooding and storm water management, and (2) pre-test communications meant to inform and empower Pittsburghers about flood risks and adaptation strategies. We conduct a city-wide survey of 10,000 Pittsburgh renters and homeowners from four life situations: high risk, above poverty; high-risk, below poverty; low risk, above poverty; and low-risk, below poverty. Mixed media recruitment strategies (online and paper-based solicitations guided/organized by community organizations) assist in reaching all subpopulations. Preliminary results suggest participants know what stormwater runoff is, but have a weak understanding of how stormwater interacts with natural and built systems. Furthermore, although participants have a good understanding of the difference between green and gray infrastructure, this does not translate into a change in their willingness to pay for green infrastructure adaptation. This suggests additional communications about flood risks and adaptation strategies.

  15. Prevalence of Clostridium difficile in Uncooked Ground Meat Products from Pittsburgh, Pennsylvania

    PubMed Central

    Marsh, Jane W.; Schlackman, Jessica L.; Harrison, Lee H.

    2012-01-01

    The prevalence of Clostridium difficile in retail meat samples has varied widely. The food supply may be a source for C. difficile infections. A total of 102 ground meat and sausage samples from 3 grocers in Pittsburgh, PA, were cultured for C. difficile. Brand A pork sausages were resampled between May 2011 and January 2012. Two out of 102 (2.0%) meat products initially sampled were positive for C. difficile; both were pork sausage from brand A from the same processing facility (facility A). On subsequent sampling of brand A products, 10/19 samples from processing facility A and 1/10 samples from 3 other facilities were positive for C. difficile. The isolates recovered were inferred ribotype 078, comprising 6 genotypes. The prevalence of C. difficile in retail meat may not be as high as previously reported in North America. When contamination occurs, it may be related to events at processing facilities. PMID:22504814

  16. Time of travel of water in the Ohio River, Pittsburgh to Cincinnati

    USGS Publications Warehouse

    Steacy, Robert E.

    1961-01-01

    This report presents a procedure for estimating the time of travel of water in the Ohio River from Pittsburgh, Pa., to Cincinnati, Ohio, under various river stage conditions. This information is primarily for use by civil defense officials and by others concerned with problems involving travel time of river water. Tables and charts are presented to show, for a particular stage or discharge at Cincinnati, the average time it would take for water to travel through the entire reach from Pittsburgh, or through successive intermediate segments of the reach. For example, when the discharge at Cincinnati is 200,000 cfs, travel time from Pittsburgh to Cincinnati, a distance of 470 miles, averages about 7 days; and for discharges of more than 200,000 cfs, the travel time decreases very slowly with increasing discharge. When the discharge is 30,000 cfs, travel time is about 28 days; and for discharges of less than 30,000 cfs, the travel time increases very rapidly with decreasing discharge. Estimates of travel time at low discharge are subject to large errors. Statistical analysis of the possible variations of upstream discharge for a given discharge at Cincinnati indicates that the shortest probable travel time from Pittsburgh to Cincinnati ranges from 56 percent of that under average conditions when the discharge at Cincinnati is 15,000 cfs to 93 percent of that under average conditions when the discharge at Cincinnati is 894,000 cfs. A chart showing the time distribution of flow at Cincinnati is presented so that the probable travel time of Ohio River water can be determined for any time of the year. This chart provides information which, when applied to the time-of-travel chart, shows that the most probable travel time of water from Pittsburgh to Cincinnati ranges from 160 hours in February to 1,250 hours in September. Also presented is a flow-duration curve that can be used to predict future discharges and, subsequently, times of travel, for use in long-range planning

  17. Simplified Space Conditioning in Low-Load Homes: Results from Pittsburgh, Pennsylvania, New Construction Unoccupied Test House

    SciTech Connect

    Poerschke, Andrew; Stecher, Dave

    2014-06-01

    Field testing was performed in a new construction unoccupied test house in Pittsburgh, PA. Four air-based heating, ventilation, and air conditioning distribution systems—a typical airflow ducted system to the bedrooms, a low airflow ducted system to the bedrooms, a system with transfer fans to the bedrooms, and a system with no ductwork to the bedrooms—were evaluated during heating, cooling, and midseason conditions. The relative ability of each system was assessed with respect to relevant Air Conditioning Contractors of America and ASHRAE standards for house temperature uniformity and stability, respectively.

  18. The Pittsburgh Girls Study: Overview and Initial Findings

    ERIC Educational Resources Information Center

    Keenan, Kate; Hipwell, Alison; Chung, Tammy; Stepp, Stephanie; Stouthamer-Loeber, Magda; Loeber, Rolf; McTigue, Kathleen

    2010-01-01

    The Pittsburgh Girls Study is a longitudinal, community-based study of 2,451 girls who were initially recruited when they were between the ages of 5 and 8 years. The primary aim of the study was testing developmental models of conduct disorder, major depressive disorder, and their co-occurrence in girls. In the current article, we summarize the…

  19. The "Pittsburgh Courier" and Black Workers in 1942.

    ERIC Educational Resources Information Center

    Washburn, Pat

    In early 1942, the "Pittsburgh Courier," the largest black newspaper in the United States, began its Double V campaign stressing the right of black workers to have equality at home when blacks were fighting inequality abroad. An examination of the campaign, however, reveals that it was dead by the end of the year, while substantial gains…

  20. The Pittsburgh Project - Part I: Community Growth and Survival.

    ERIC Educational Resources Information Center

    Taylor, Jerome

    This paper presents a summary of the first part of the Pittsburgh Project. It deals with white racialism. "Racialism" is a term that is used differently, explained differently, and deployed differently to account for a heterogeneous range of social phenomena. Not uncommonly, assumptions are made that racialism is a unitary rather than a…

  1. Sexism in Textbooks in Pittsburgh Public Schools, Grades K-5.

    ERIC Educational Resources Information Center

    Scardina, Florence

    Thirty-six textbooks used by the Pittsburgh public schools at grade levels K-5 were reviewed to see how they treat girls vs. boys and men vs. women. Language, reading, science, social studies, and mathematics texts were evaluated. Blatant sexism is found in all areas. Different ideas of behavior and mores are propagated for boys than for girls;…

  2. The Pittsburgh Girls Study: Overview and Initial Findings

    ERIC Educational Resources Information Center

    Keenan, Kate; Hipwell, Alison; Chung, Tammy; Stepp, Stephanie; Stouthamer-Loeber, Magda; Loeber, Rolf; McTigue, Kathleen

    2010-01-01

    The Pittsburgh Girls Study is a longitudinal, community-based study of 2,451 girls who were initially recruited when they were between the ages of 5 and 8 years. The primary aim of the study was testing developmental models of conduct disorder, major depressive disorder, and their co-occurrence in girls. In the current article, we summarize the…

  3. A Discussion of the Pittsburgh Reading Conference Papers.

    ERIC Educational Resources Information Center

    Samuels, S. J.

    Reviews and evaluative comments concerning the 11 papers read during the April 1976 portion of the Pittsburgh conference on the theory and practice of beginning reading are included in this document. Before the papers are reviewed, information is presented on some questions posed at the conference within the context of two issues that were raised…

  4. An Evaluation of the Pittsburgh Reading is FUNdamental Program.

    ERIC Educational Resources Information Center

    Boldovici, John A.; And Others

    A study of one of the model "Reading is FUNdamental" (RIF) programs located in Pittsburgh, Pennsylvania, was made to determine the success of the program and to formulate suggestions for changes. RIF is a program in which free or inexpensive books are made available in a community through schools, libraries, and other local organizations…

  5. The "Pittsburgh Courier's" Double V Campaign in 1942.

    ERIC Educational Resources Information Center

    Washburn, Pat

    In February 1942, a letter to the editor of the Pittsburgh "Courier," the nation's largest black owned newspaper, started the "Double V" (for victory at home and victory abroad) campaign, which stressed the right of blacks to have equality in the United States since they were fighting inequality abroad. As the…

  6. Pathways to Sustainability for Carnegie Library of Pittsburgh. Research Brief

    ERIC Educational Resources Information Center

    Li, Jennifer

    2008-01-01

    Like many U.S. public libraries, Carnegie Library of Pittsburgh faces financial uncertainty. CLP asked RAND to identify critical factors that affect the library's financial stability and to develop a framework to assess how these factors can be managed to provide a more stable financial base. RAND researchers reviewed the literature and…

  7. Perspectives on Art Therapy: The Proceedings of the Pittsburgh Conference on Art Therapy (2nd, Pittsburgh, Pennsylvania, May 20, 1977).

    ERIC Educational Resources Information Center

    Roth, Ellen A., Ed.; Rubin, Judith A., Ed.

    The proceedings of the 2nd annual Pittsburgh Conference on Art Therapy (with handicapped persons) consists of 44 items including full length papers, summaries of previously published papers, descriptions of workshops, and a limited number of abstracts (submitted by those who chose not to present a paper or workshop description). The papers are…

  8. Perspectives on Art Therapy: The Proceedings of the Pittsburgh Conference on Art Therapy (2nd, Pittsburgh, Pennsylvania, May 20, 1977).

    ERIC Educational Resources Information Center

    Roth, Ellen A., Ed.; Rubin, Judith A., Ed.

    The proceedings of the 2nd annual Pittsburgh Conference on Art Therapy (with handicapped persons) consists of 44 items including full length papers, summaries of previously published papers, descriptions of workshops, and a limited number of abstracts (submitted by those who chose not to present a paper or workshop description). The papers are…

  9. Recommendations from the AIA/SEI Workshop on Research Advances Required for Real-Time Software Systems in the 1990s Held in Pittsburgh, Pennsylvania on 13-14 September 1989

    DTIC Science & Technology

    1989-09-14

    MS WT-1 7 (513) 255-3947 Dallas, TX 75265-0003 (214) 266-7791 Walt Scacchi Assistant Professor Daniel P. Siewiorek University of Southern California...Pittsburgh, PA 15213-3890 scacchi @pollux.usc.edu (412) 268-2570 arpanet:dps@a.gp.cs.cmu.edu Lui Sha Senior Member of the Technical Staff David R. Smith

  10. Bettis Atomic Power Laboratory. Bettis-Pittsburgh Site environmental summary report

    SciTech Connect

    2000-08-01

    This summary report provides a description of the nature and environmental aspects of work and facilities at the Bettis-Pittsburgh site, an historical perspective of Bettis-Pittsburgh operations that is not provided by the annual reports, and background information pertinent to understanding the environmental aspects of Bettis-Pittsburgh operations.

  11. The upper pennsylvanian pittsburgh coal bed: Resources and mine models

    USGS Publications Warehouse

    Watson, W.D.; Ruppert, L.F.; Tewalt, S.J.; Bragg, L.J.

    2001-01-01

    The U.S. Geological Survey recently completed a digital coal resource assessment model of the Upper Pennsylvanian Pittsburgh coal bed, which indicates that after subtracting minedout coal, 16 billion short tons (14 billion tonnes) remain of the original 34 billion short tons (31 billion tonnes) of coal. When technical, environmental, and social restrictions are applied to the remaining Pittsburgh coal model, only 12 billion short tons (11 billion tonnes) are available for mining. Our assessment models estimate that up to 0.61 billion short tons (0.55 billion tonnes), 2.7 billion short tons (2.4 billion tonnes), and 8.5 billion short tons (7.7 billion tonnes) could be available for surface mining, continuous mining, and longwall mining, respectively. This analysis is an example of a second-generation regional coal availability study designed to model recoverability characteristics for all the major coal beds in the United States. ?? 2001 International Association for Mathematical Geology.

  12. Pittsburgh Registry of Infant Multiplets (PRIM): an update.

    PubMed

    Jenkins, Elizabeth A; Maher, Brion S; Marazita, Mary L; Tarter, Ralph E; Ganger, Jennifer B; Watt-Morse, Margaret; Vanyukov, Michael M

    2006-12-01

    This article is an updated review of the Pittsburgh Registry of Infant Multiplets including recruitment methods, data collection, and results of pilot studies conducted in this registry. The main goal of the registry is to study psychological development. The risk for behavior disorders including substance use disorders, as well as language development and dental health are among research targets. Pilot data on the heritability of minor physical anomalies and neuropsychological characteristics (Continuous Performance Test) are reported.

  13. Preparing for local adaptation: Understanding flood risk perceptions in Pittsburgh

    NASA Astrophysics Data System (ADS)

    Wong-Parodi, G.; Klima, K.

    2016-12-01

    In cities such as Pittsburgh, aging and insufficient infrastructure contributes to flashfloods and numerous combined sewer overflows annually, contaminating streets, basements and waterways. Climate change is expected to further exacerbate this problem by causing more intense and more frequent extreme events in Western Pennsylvania. For a storm water adaptation plan to be implemented successfully, the City of Pittsburgh will need informed public support. One way to achieve public understanding and support is through effective communication of the risks, benefits, and uncertainties of local flooding hazards and adaptation methods. In order to develop risk communications effectively, the City and its partners will need to know what knowledge and attitudes the residents of Pittsburgh already hold about flood risks. To that end we surveyed 1,376 Pittsburgh residents on a variety of flood risk topics through an online or paper survey in Fall 2015. On balance, residents were relatively knowledgeable about storm water and see the City's current infrastructure as being inadequate to meet future risk. Moreover, they see the risk of runoff events as increasing and especially among those who live in hazardous flood areas. Residents expressed interest in having a dedicated fund to deal with runoff events. Among those queried about their willingness-to-pay, those asked to pay $15 were most interested in a dedicated fund and for green infrastructure (as opposed to gray infrastructure) in particular. Finally, while most residents favored green infrastructure in terms of its attractiveness and perceived affects on mitigating climate change many did not see it as effective at addressing flooding as gray infrastructure. We found people understand the risk and are open to doing something about it. However, more guidance and information on appropriate ways to adapt locally in terms that make sense to residents could enhance informed support for adaptation measures.

  14. Abstracts of Papers Presented at the 2005 Pittsburgh Conference

    PubMed Central

    Stockwell, Peter B.

    2005-01-01

    To attend or not to attend, that is the question. The Pittsburgh Conference continues to pose this conundrum to conferees and exhibitors alike. This year's conference was the first to be presented without a set of paper abstracts—a good thing some would say but this old codger always used the paper abstracts to select papers of interest to our readership and to seek a full publication. The exhibit took its usual format but it seemed that there were less manufacturers present. The information presented to the attendees was also lacking and many companies' details were missing from the final program book, an omission no doubt on their behalf—my company was one of these—however I feel sure that past Pittcon organizers would have been more persistent in getting the required details for the audience. As is now the norm, many of the presentations take the form of posters displayed within the exhibition area. Without a driver to get the audience there, the traffic was slow, to say the least. Lecture presentations were also attended in a mixed fashion. So the Pittsburgh Conference show moves on, and again next year it will be held in Orlando from 12 March to 17 March 2006. No doubt I will be there making it a straight 31 in a row; in Pittsburgh Conference terms I am just a beginner with many of the attendees making more shows in a run than that. Selected abstracts dealing with topics of interest to the readers of this journal follow—hopefully many of these groups will be willing to publish their work either within this journal or elsewhere. PMID:18924631

  15. The Pittsburgh Fatigability Scale for Older Adults: Development and Validation

    PubMed Central

    Glynn, Nancy W.; Santanasto, Adam J.; Simonsick, Eleanor M.; Boudreau, Robert M.; Beach, Scott R.; Schulz, Richard; Newman, Anne B.

    2016-01-01

    OBJECTIVES To describe the development of the Pittsburgh Fatigability Scale (PFS) and establish its reliability and concurrent and convergent validity against performance measures. DESIGN Cross-sectional. SETTING University of Pittsburgh, Pittsburgh, Pennsylvania. PARTICIPANTS Scale development sample: 1,013 individuals aged 60 and older from two registries; validation sample: 483 adults aged 60 and older from the Baltimore Longitudinal Study of Aging (BLSA). MEASUREMENTS The scale development sample and BLSA participants self-administered an initial 26-item perceived fatigability scale. BLSA participants also completed measures of performance fatigability (perceived exertion from a standard treadmill task and performance deterioration from a fast-paced long-distance corridor walk), a 6-m usual-paced corridor walk, and five timed chair stands. RESULTS Principal components analysis with varimax rotation reduced the 26-item scale to the 10-item PFS. The PFS showed strong internal consistency (Cronbach’s alpha 0.88) and excellent test–retest reliability (intraclass correlation 0.86). In the validation sample, PFS scores, adjusted for age, sex, and race, were greater for those with high performance fatigability, slow gait speed, worse physical function, and lower fitness, with differences between high and low fatigability ranging from 3.2 to 5.1 points (P < .001). CONCLUSION The 10-item PFS physical fatigability score is a valid and reliable measure of perceived fatigability in older adults and can serve as an adjunct to performance- based fatigability measures for identifying older adults at risk of mobility limitation in clinical and research settings. PMID:25556993

  16. Cofiring Wood and Coal to Stoker Boilers in Pittsburgh

    SciTech Connect

    Cobb, J.T., Jr.; Elder, W.W.

    1997-07-01

    The prime objective of the University of Pittsburgh's overall wood/coal cofiring program is the successful introduction of commercial cofiring of urban wood wastes into the stoker boilers of western Pennsylvania. Central to this objective is the demonstration test at the Pittsburgh Brewing Company. In this test the project team is working to show that two commercially-available clean wood wastes - tub-ground pallet waste and chipped clearance wood - can be included in the fuel fed daily to an industrial stoker boiler. Irrespective of its economic outcome, the technical success of the demonstration at the brewery will allow the local air quality regulation agency to permit a parametric test at the Bellefield Boiler Plant. The objective of this test is to obtain comprehensive data on all key parameters of this operational boiler while firing wood with coal. The data would then be used for thorough generic technical and economic analyses. The technical analysis would be added to the open literature for the general planning and operational guidance for boiler owners and operators. The economic analysis would gage the potential for providing this stoker fuel commercially in an urban setting and for purchasing it regularly for combustion in an urban stoker boiler.

  17. Selective agglomeration of a Pittsburgh Seam coal with isooctane

    SciTech Connect

    Lai, R.; Killmeyer, R.; Utz, B.; Richardson, A.; Sinha, K.

    1992-01-01

    The Pittsburgh Energy Technology Center initiated a research program in 1989 to investigate the fundamentals of selective agglomeration as applied to the cleaning of coals. The results of the initial study with Bruceton mine, Pittsburgh seam coal, using isooctane as an agglomerant, have been published. Subsequent to the successful reduction of the ash content of Bruceton coal to less than 0.9% after two cleaning stages, the study was extended to compare a coal from the same seam, but from Ohio. In the previous parameter optimization tests with Bruceton coal, particle size and slurry pH were found to be important parameters governing coal cleanability. Other researchers have obtained similar conclusions of the effects of particle size and coal slurry pH on the cleanability of various coals. In this study, the effects of these parameters on the cleanability of Powhatan coal were examined. Particle size reduction kinetics was examined first. Effects of size reduction (degree of mineral matter liberation), oil (isooctane)-to-coal ratio, and slurry pH on mineral matter rejection and combustible recovery were also examined. A petrographic comparison was conducted on the Powhatan and Bruceton coals to examine the degree of pyrite liberation as a function of particle size to elucidate why one coal from the same seam can be cleaned significantly better than another. (VC)

  18. Creating a Methodology for Coordinating High-resolution Air Quality Improvement Map and Greenhouse Gas Mitigation Strategies in Pittsburgh City

    NASA Astrophysics Data System (ADS)

    Shi, J.; Donahue, N. M.; Klima, K.; Blackhurst, M.

    2016-12-01

    In order to tradeoff global impacts of greenhouse gases with highly local impacts of conventional air pollution, researchers require a method to compare global and regional impacts. Unfortunately, we are not aware of a method that allows these to be compared, "apples-to-apples". In this research we propose a three-step model to compare possible city-wide actions to reduce greenhouse gases and conventional air pollutants. We focus on Pittsburgh, PA, a city with consistently poor air quality that is interested in reducing both greenhouse gases and conventional air pollutants. First, we use the 2013 Pittsburgh Greenhouse Gas Inventory to update the Blackhurst et al. model and conduct a greenhouse gas abatement potentials and implementation costs of proposed greenhouse gas reduction efforts. Second, we use field tests for PM2.5, NOx, SOx, organic carbon (OC) and elemental carbon (EC) data to inform a Land-use Regression Model for local air pollution at a 100m x 100m spatial level, which combined with a social cost of air pollution model (EASIUR) allows us to calculate economic social damages. Third, we combine these two models into a three-dimensional greenhouse gas cost abatement curve to understand the implementation costs and social benefits in terms of air quality improvement and greenhouse gas abatement for each potential intervention. We anticipated such results could provide policy-maker insights in green city development.

  19. Proceedings, 1995 meeting of the Northern Global Change Program; 1995 March 14-16; Pittsburgh, PA. : Introduction/Environmental Change

    Treesearch

    John Hom; Richard Birdsey; Kelly O' Brian; eds.

    1996-01-01

    Contains articles presented at the 1995 Northern Global Change Program meeting on the following topics: monitoring and predicting regional environmental change, responses of northern tree species to regional stress, responses of ecosystem processes to regional stress, forest and landscape responses to regional stress and management activities, human-forest interactions...

  20. EnviroAtlas - Pittsburgh, PA - Domestic Water Use per Day by U.S. Census Block Group

    EPA Pesticide Factsheets

    As included in this EnviroAtlas dataset, the community level domestic water use was calculated using locally available water use data per capita in gallons of water per day (GPD), distributed dasymetrically, and summarized by census block group. Domestic water use, as defined in this case, is intended to represent residential indoor and outdoor water use (e.g., cooking hygiene, landscaping, pools, etc.) for primary residences (i.e., excluding second homes and tourism rentals). For the purposes of this metric, these publicly-supplied estimates are also applied and considered representative of local self-supplied water use. Domestic water demand was calculated and applied using the Pennsylvania Department of Environmental Protection (PADEP) PWS Service Areas layer, population served per provider, and average water use per provider. Within the EnviroAtlas study area, there are 43 service providers with 2010-2013 estimates ranging from 34 to 102 GPD.This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can

  1. Annual Conference on Magnetism and Magnetic Materials, 29th, Pittsburgh, PA, November 8-11, 1983, Proceedings

    SciTech Connect

    Hasegawa, R.; Koon, N.C.; Cooper, B.R.

    1984-03-15

    Various topics on magnetism and magnetic materials are addressed. The subjects considered include: spin glasses, amorphous magnetism, actinide and rare earth intermetallics, magnetic excitation, itinerant magnetism and magnetic structure, valence instabilities, Kondo effect, transport and Hall effects, mixed valence and Kondo compounds, superconductivity and magnetism, d and f electron magnetism and superconductivity, Fe-based microcrystalline and permanent magnetic alloys, hard and soft magnetic materials, and magnetooptics. Also discussed are: numerical methods for magnetic field computation, recording theory and experiments, recording heads and media, magnetic studies via hyperfine interactions, magnetic semiconductors, magnet insulators, transition metal systems, random fields, critical phenomena and magnetoelastic effects and resonance, surfaces and interfaces, magnetostatic waves and resonance, bubble materials and implantation, bubble devices and physics, magnetic separation, ferrofluids, magnetochemistry, new techniques and materials, and new applications.

  2. The Pittsburgh Girls Studies: Overview and Initial Findings

    PubMed Central

    Keenan, Kate; Hipwell, Alison; Chung, Tammy; Stepp, Stephanie; Stouthamer-Loeber, Magda; Loeber, Rolf; McTigue, Kathleen

    2010-01-01

    The Pittsburgh Girls Study is a longitudinal, community–based study of 2,451 girls who were initially recruited when they were between the ages of 5 and 8 years. The primary aim of the study was testing developmental models of conduct disorder (CD), major depressive disorder (MDD), and their co-occurrence in girls. In the current paper, we summarize the published findings from the past 5 years of the PGS and place those results in the context of what it known to date about developmental psychopathology in girls. Key results suggest that DSM-IV mental disorders tend to have an insidious onset often beginning with sub-syndromal symptom manifestation and that there appear to be shared and unique developmental precursors to disorder in subgroups of girls based on race and poverty. PMID:20589562

  3. Psychiatric sequelae after traumatic injury: the Pittsburgh Regatta accident.

    PubMed

    Martini, D R; Ryan, C; Nakayama, D; Ramenofsky, M

    1990-01-01

    Accidental injury in a child is sudden, often violent, and emotionally stressful, particularly when it is accompanied by hospitalization and rehabilitation. The following case report examines the presence of post-traumatic stress disorder and other psychiatric illnesses in five children involved in a boating accident during the 1988 Pittsburgh Regatta and considered severity of injury as well as complicating psychosocial stressors in the development of the disorders. The presence of symptoms was not related to the nature or extent of the injury but was instead the by-product of additional factors, including level of family stress, coping styles of the patient and family, positive psychiatric history in the child and/or family, and experience in effectively dealing with stressful episodes in the past.

  4. Lighting retrofits at the Pittsburgh Zoo and Aviary

    SciTech Connect

    Sadowski, E.C.

    1995-09-01

    The Pittsburgh Zoo occupies approximately 52 acres in the City`s Highland Park. Thirty structures serve as animal holding facilities, public display buildings, classrooms, food service facilities, offices, warehouses, a veterinary hospital, and gift shops. The cost of energy for heating, cooling, lighting, pumping, food service, etc. is approximately $280,000 a year. Of this, about 79 percent, or $220,000, is spent for electricity. About 20 percent ($44,000) of that electricity cost is spent directly on lighting. In mid-1992 a series of retrofits to the lighting systems in the Zoo`s buildings was begun. These were completed in mid-1994. These improvements cost $127,690, and they are expected to reduce electricity costs by $24,500 a year. The most interesting projects were carried out in the Tropical Forest Building, the Aqua Zoo, and the Niches of the World Building.

  5. Translating the Pittsburgh Sleep Quality Index into Arabic.

    PubMed

    Suleiman, Khaled H; Yates, Bernice C; Berger, Ann M; Pozehl, Bunny; Meza, Jane

    2010-03-01

    This descriptive correlational study describes the translation process and the psychometric testing of the Pittsburgh Sleep Quality Index (PSQI). The PSQI has been successfully translated into Arabic and back-translated into English by 10 Arabic bilingual translators. Then the PSQI is tested in a sample of 35 healthy Arabic bilinguals.The internal consistency reliability for the Global PSQI demonstrates borderline acceptability (Cronbach's alpha = .65). The reliability is further supported by moderate to high correlations between five PSQI components and the global PSQI score (r = .53 to .82, p < .01). Convergent validity is supported by the global PSQI correlating strongly with the Insomnia Severity Index (r = .76) and moderately with the related construct of the Medical Outcome Study Short Form-36 vitality subscale (r = -.33). Further testing of the PSQI is needed in a larger Arabic population, both clinical and healthy populations, living in their native countries.

  6. The Pittsburgh Girls Study: overview and initial findings.

    PubMed

    Keenan, Kate; Hipwell, Alison; Chung, Tammy; Stepp, Stephanie; Stouthamer-Loeber, Magda; Loeber, Rolf; McTigue, Kathleen

    2010-01-01

    The Pittsburgh Girls Study is a longitudinal, community-based study of 2,451 girls who were initially recruited when they were between the ages of 5 and 8 years. The primary aim of the study was testing developmental models of conduct disorder, major depressive disorder, and their co-occurrence in girls. In the current article, we summarize the published findings from the past 5 years of the PGS and place those results in the context of what it known to date about developmental psychopathology in girls. Key results suggest that DSM-IV mental disorders tend to have an insidious onset often beginning with subsyndromal symptom manifestation, and that there appear to be shared and unique developmental precursors to disorder in subgroups of girls based on race and poverty.

  7. Aging and space flight: findings from the University of Pittsburgh

    NASA Technical Reports Server (NTRS)

    Monk, T. H.

    1999-01-01

    For more than a decade, the Sleep and Chronobiology Center (SCC) at the University of Pittsburgh has received funding from the National Institute on Aging (NIA), the National Institute of Mental Health (NIMH) and the National Aeronautics and Space Administration (NASA) in order to study the sleep and circadian rhythms of healthy older people, as well as the sleep and circadian rhythms of astronauts and cosmonauts. We have always been struck by the strong synergism between the two endeavors. What happens to the sleep and circadian rhythms of people removed from the terrestrial time cues of Earth is in many ways similar to what happens to people who are advancing in years. Most obviously, sleep is shorter and sleep depth is reduced, but there are also more subtle similarities between the two situations, both in circadian rhythms and in sleep, and in the adaptive strategies needed to enhance 24h zeitgebers.

  8. Aging and space flight: findings from the University of Pittsburgh

    NASA Technical Reports Server (NTRS)

    Monk, T. H.

    1999-01-01

    For more than a decade, the Sleep and Chronobiology Center (SCC) at the University of Pittsburgh has received funding from the National Institute on Aging (NIA), the National Institute of Mental Health (NIMH) and the National Aeronautics and Space Administration (NASA) in order to study the sleep and circadian rhythms of healthy older people, as well as the sleep and circadian rhythms of astronauts and cosmonauts. We have always been struck by the strong synergism between the two endeavors. What happens to the sleep and circadian rhythms of people removed from the terrestrial time cues of Earth is in many ways similar to what happens to people who are advancing in years. Most obviously, sleep is shorter and sleep depth is reduced, but there are also more subtle similarities between the two situations, both in circadian rhythms and in sleep, and in the adaptive strategies needed to enhance 24h zeitgebers.

  9. An organizational survey of the Pittsburgh Energy Technology Center

    SciTech Connect

    Stock, D.A.; Shurberg, D.A.; Haber, S.B.

    1991-09-01

    An Organizational Survey (OS) was administrated at the Pittsburgh Energy Technology Center (PETC) that queried employees on the subjects of organizational culture, various aspects of communications, employee commitment, work group cohesion, coordination of work, environmental, safety, and health concerns, hazardous nature of work, safety and overall job satisfaction. The purpose of the OS is to measure in a quantitative and objective way the notion of ``culture``; that is, the values attitudes, and beliefs of the individuals working within the organization. In addition, through the OS, a broad sample of individuals can be reached that would probably not be interviewed or observed during the course of a typical assessment. The OS also provides a descriptive profile of the organization at one point in time that can then be compared to a profile taken at a different point in time to assess changes in the culture of the organization.

  10. An organizational survey of the Pittsburgh Energy Technology Center

    SciTech Connect

    Stock, D.A.; Shurberg, D.A.; Haber, S.B.

    1991-09-01

    An Organizational Survey (OS) was administrated at the Pittsburgh Energy Technology Center (PETC) that queried employees on the subjects of organizational culture, various aspects of communications, employee commitment, work group cohesion, coordination of work, environmental, safety, and health concerns, hazardous nature of work, safety and overall job satisfaction. The purpose of the OS is to measure in a quantitative and objective way the notion of culture''; that is, the values attitudes, and beliefs of the individuals working within the organization. In addition, through the OS, a broad sample of individuals can be reached that would probably not be interviewed or observed during the course of a typical assessment. The OS also provides a descriptive profile of the organization at one point in time that can then be compared to a profile taken at a different point in time to assess changes in the culture of the organization.

  11. Pneumonia caused by Pittsburgh pneumonia agent: radiologic manifestations

    SciTech Connect

    Muder, R.R.; Reddy, S.C.; Yu, V.L.; Kroboth, F.J.

    1984-03-01

    Using an objective scoring system, chest radiographs were reviewed in 23 cases of pneumonia due to the Pittsburgh pneumonia agent (PPA, Tatlockia micdadei, Legionella micdadei), including six cases of pneumonia with simultaneous isolation of PPA and L pneumophila (Legionnaires' disease). Infiltrates were typically segmental to lobar; nodular infiltrates were noted in three cases. Spread to additional lobes after presentation occurred in four of 17 PPA infections. Pneumonia caused by both PPA and L pneumophila was unusually severe, with involvement of all lobes occurring in four of six cases, compared with one of 17 cases of PPA infection (p>0.02). Radiographic severity did not correlate with underlying disease, immune status, or outcome. The majority of patients receiving erythromycin demonstrated objective radiologic improvement. In a patients, population that included nonimmunosuppressed patient, nodule formation and rapid radiologic progression were not found to be characteristic of PPA pneumonia.

  12. Lighting retrofits at the Pittsburgh Zoo and Aviary

    SciTech Connect

    Sadowski, E.C.

    1995-06-01

    Energy bills for the Pittsburgh Zoo typically total $280,000 a year, of which about $220,000 are spent on electricity. Until recently, lighting accounted for 20 percent of this electricity use. This translated into an annual cost of $44,000. Recent advances in lighting technology have made it possible to perform lighting retrofits in Zoo facilities that reduce energy costs while also providing improved light quality and better lit and more natural looking exhibits and animal holding areas. Through an investment of $127,690 in these projects from mid-1992 through mid-1994, the Zoo expects to realize an annual savings in electricity costs of $24,500 and further savings from a reduction in maintenance and plant replacement costs. Retrofits to the lighting systems in the Tropical Forest Building, the Aquarium, and the Niches of the World Building were the most interesting and are described in detail. Providing a sufficient amount of ultraviolet light to maintain the health of reptiles was a particular challenge in the Niches of the World Building. Lack of separate meters and additions to the Zoo have made the determination of the actual performance of these retrofit projects impossible. A similar retrofit project at the Pittsburgh Aviary (now the National Aviary) in 1989 through 1990 provides savings figures that should be comparable to those expected at the Zoo, however. This project cost $100,000 and saved $21,008 in electricity costs during the first year of operation. Maintenance costs were reduced by approximately $5000 a year.

  13. Guide to Historic Hungarian Places in Greater Pittsburgh. Educational Curriculum Kit 3.

    ERIC Educational Resources Information Center

    Boros-Kazai, Andrew

    This booklet is a guide to buildings and other sites which have played a significant role in the history of the Hungarian community in Pittsburgh (Pennsylvania). A brief summary of the significance or present use is provided for: (1) the Hungarian Nationality room at the University of Pittsburgh's Cathedral of Learning; (2) special collections of…

  14. Psychometric Analysis of the Pittsburgh Insomnia Rating Scale among University Population of Poor Sleepers in India.

    PubMed

    Veqar, Zubia; Moiz, Jamal Ali; Hussain, Mohammed Ejaz

    2014-04-01

    Pittsburgh insomnia rating scale is a 65 item self administered open source questionnaire. The scale is widely used in clinical practice but its psychometric properties are not well established. Therefore keeping in mind this lacuna the current study was designed for university population of poor sleepers in India. The purpose of this study was to establish the Pittsburgh sleep Quality Index test- retest reliability, validity and internal consistency of Pittsburgh insomnia rating scale. Twenty five subjects were randomly chosen from the screened population of poor sleepers. Pittsburgh insomnia rating scale, Pittsburgh sleep quality index and Insomnia severity index were administered on test day. Retest was administered after one week. Eight males and seventeen females with mean age 24 + 7.04 were recruited. The test retest reliability for Pittsburgh insomnia rating scale total score showed excellent reliability (ICC2,1-0.93). The results also show that the total score is moderately correlated with Pittsburgh sleep Quality Index (r-0.31) and moderately correlated with Insomnia severity index (r-0.49). Internal consistency for the test was excellent (Cronbach's alpha- 0.930). The study findings suggest that Pittsburgh insomnia rating scale has excellent internal consistency, test-retest reliability and good validity for university population of poor sleepers in India. It is an important first line of assessment scale for screening of sleep problems.

  15. Estimating Teacher and School Effectiveness in Pittsburgh: Value-Added Modeling and Results. Final Report

    ERIC Educational Resources Information Center

    Lipscomb, Stephen; Gill, Brian; Booker, Kevin; Johnson, Matthew

    2010-01-01

    At the request of Pittsburgh Public Schools (PPS) and the Pittsburgh Federation of Teachers (PFT), Mathematica is developing value-added models (VAMs) that aim to estimate the contributions of individual teachers, teams of teachers, and schools to the achievement growth of their students. The analyses described in this report are intended as an…

  16. PRISM: Pittsburgh Research-Based Instructional Supervisory Model. A Staff Development Program.

    ERIC Educational Resources Information Center

    Wallace, Richard C., Jr.

    Addressing the Pittsburgh public school system's need for staff evaluation, Pittsburgh's Research-Based Instructional Supervisory Model (PRISM) is an adaptation of Madeline Hunter's materials on effective teaching and Theodore Forte's synthesis of Hunter's materials in his "Workshop on Instructional Skills." While total PRISM…

  17. Forging a New Partnership: The Story of Teacher Union and School District Collaboration in Pittsburgh

    ERIC Educational Resources Information Center

    Hamill, Sean D.

    2011-01-01

    This paper documents Pittsburgh's transformation from a typical, adversarial district-union dynamic to one of deep, substantive collaboration over the course of several years. This work has catapulted Pittsburgh to the vanguard of efforts to improve teacher effectiveness, and helped secure more than $80 million in philanthropic and federal grants.…

  18. The Impact of The University of Pittsburgh on the Local Economy.

    ERIC Educational Resources Information Center

    Pittsburgh Univ., PA. University Urban Interface Program.

    One of the projects selected for the University Urban Interface Program at the University of Pittsburgh was that of studying the impact of the university on the city of Pittsburgh. In pursuing this goal, studies were made of university-related local business volume; value of local business property committed to university-related business; credit…

  19. The Impact of the University of Pittsburgh on the Local Economy. Methodological Appendix.

    ERIC Educational Resources Information Center

    Pittsburgh Univ., PA. University Urban Interface Program.

    This document presents the procedures used, the results of, and recommendations concerning a study designed to determine the impact of the University of Pittsburgh on the local economy. Findings include the following expenditures by faculty, staff and students in the Pittsburgh area: (1) Colleges related local business volume--$177.3 million; (2)…

  20. Homeopathy in the USA.

    PubMed

    Thomas, P

    2001-04-01

    Homeopathy was introduced into the USA by Hans Burch Gram in 1825. It developed largely through immigration of German homeopaths. The first homeopathic medical college was established in Allentown, PA in 1835. The American institute of Homeopathy (AIH) was founded in 1844. The American Medical Association was founded in 1847 and pursued policies hostile to homeopathy from the outset. Eclectic medicine was widespread in nineteenth century medicine, one of the greatest homeopaths, JT Kent had originally been an eclectic. The International Hahnemannian Association split from the AIH in 1880. The Flexner Report of 1910 resulted in many homeopathic medical colleges being closed down. Homeopathy in the USA was in steep decline from the 1920s to the 1960s but has had a strong recovery since the 1970s.

  1. National Dam Inspection Program, Big Beaver Dam (Pa No Name Number 14, NDI Number PA 00258, PennDER Number 4-11), Ohio River Basin, Tributary of Clark’s Run, Beaver County, Pennsylvania. Phase I Inspection Report,

    DTIC Science & Technology

    1980-02-01

    the Allegheny Group , Pennsylvanian System. These members consist of cyclic sequences of shale, sandstone, limestone, and coal. It is estimated that the...4, GEOLOGIC MAP Blg Beaver Dom NDI No. PA 00258 Beaver County c Reproduced from Greater Pittsburgh Region Geologic Map. -A% 0 4 Compiled by W. R...Wagner and others, 1975 N Scale: One Inch Equals Approximately Two Miles See Legend, Next Page GEOLOGY MAP LEGEND GROUP FORMATION DESCRIPTION Alluvium

  2. PM10 air pollution exposure during pregnancy and term low birth weight in Allegheny County, PA, 1994-2000.

    PubMed

    Xu, Xiaohui; Sharma, Ravi K; Talbott, Evelyn O; Zborowski, Jeanne V; Rager, Judy; Arena, Vincent C; Volz, Conrad Dan

    2011-03-01

    Low birth weight has been associated with increased risks of mortality and/or morbidity in childhood and adulthood. Epidemiological studies suggest that maternal exposure to air pollution, especially particulate matter during pregnancy, is associated with an increased risk of delivering a low birth weight infant. The aim of this study is to explore the association between exposure to particulate matter (PM10) during pregnancy and term low birth weight (LBW: birth weight <2,500 g and gestation age ≥ 37 weeks). Birth data from the Allegheny County Health Department, Pittsburgh, PA, USA and PM10 air data generated with inverse-distance interpolation by RAND's Center for Population Health and Health Disparities, were obtained. The study population consisted of all term singleton live births (gestational age ≥ 37 weeks) born between January 1, 1994 to December 31, 2000. Infants with birth weight <2,500 g were classified as LBW. Logistic regression with robust variance estimation was performed to estimate the odds ratios of LBW per inter-quartile range increase in PM10. The results showed that the odds ratios of term LBW per inter-quartile range increase in PM10 were 1.13 (95% CI: 1.02-1.25) during the first trimester and 1.10 (95% CI: 1.00-1.22) during the second trimester after adjustment for other important covariates, respectively. The findings of the study support the hypothesis that exposure to PM10 is associated with increased levels of term LBW. Further studies are warranted to corroborate these findings.

  3. Pittsburgh compound B and the postmortem diagnosis of Alzheimer disease.

    PubMed

    Niedowicz, Dana M; Beckett, Tina L; Matveev, Sergey; Weidner, Adam M; Baig, Irfan; Kryscio, Richard J; Mendiondo, Marta S; LeVine, Harry; Keller, Jeffrey N; Murphy, M Paul

    2012-10-01

    Deposition of the amyloid-β (Aβ) peptide in neuritic plaques is a requirement for the diagnosis of Alzheimer disease (AD). Although the continued development of in vivo imaging agents such as Pittsburgh compound B (PiB) is promising, the diagnosis of AD is still challenging. This can be partially attributed to our lack of a detailed understanding of the interrelationship between the various pools and species of Aβ and other common indices of AD pathology. We hypothesized that recent advances in our ability to accurately measure Aβ postmortem (for example, using PiB), could form the basis of a simple means to deliver an accurate AD diagnosis. We conducted a comprehensive analysis of the amount of Aβ40 and Aβ42 in increasingly insoluble fractions, oligomeric Aβ, and fibrillar Aβ (as defined by PiB binding), as well as plaques (diffuse and neuritic), and neurofibrillary tangles in autopsy specimens from age-matched, cognitively normal controls (n = 23) and AD (n = 22) cases, across multiple brain regions. Both PiB binding and the amount of sodium dodecyl sulfate (SDS)-soluble Aβ were able to predict disease status; however, SDS-soluble Aβ was a better measure. Oligomeric Aβ was not a predictor of disease status. PiB binding was strongly related to plaque count, although diffuse plaques were a stronger correlate than neuritic plaques. Although postmortem PiB binding was somewhat useful in distinguishing AD from control cases, SDS-soluble Aβ measured by standard immunoassay was substantially better. These findings have important implications for the development of imaging-based biomarkers of AD. Copyright © 2012 American Neurological Association.

  4. The 1985 pittsburgh conference: a special instrumentation report.

    PubMed

    1985-03-29

    For the first time in its 36 years of operation, the Pittsburgh Conference and Exposition on Analytical Chemistry and Applied Spectroscopy had a sharp drop in attendance-down 16 percent to 20,731. That loss was attributed to the fact that the meeting was held in New Orleans for the first time, and most of the lost attendees were students and young professionals who had previously come for only 1 day. The number of exhibitors and the number of booths, however, were both up about 15 percent, to 730 and 1856, respectively. A large proportion of that increase was contributed by foreign companies exhibiting for the first time, but there were also some well-known names, such as General Electric and Xerox, making first forays into analytical chemistry. There was also a sharp increase in the number and type of instruments displayed. "The key skill now in analytical chemistry," says Perkin-Elmer president Horace McDonell, Jr., "may be simply finding the right tool to obtain the answers you need." The predominant theme of the show, as it has been for the past few years, was automation of both laboratories and instruments. That trend is having major effects in chemical laboratories, but it is also affecting the instrument companies themselves. At large companies such as Varian, Beckman, and Perkin-Elmer, as much as 50 percent of the research and development budget is now going toward development of software-a much higher percentage than it was even 5 years ago. Another trend in automation also seemed clear at the show. As recently as 2 or 3 years ago, much of the available software for chemistry was designed for Apple and similar computers. Now, the laboratory standard is the IBM PC. As a representative of another company that manufactures computers noted with only slight exaggeration, "There's probably not a booth on the floor that doesn't have one."

  5. Smoky ol' town: the significance of Pittsburgh in U.S. air pollution history

    SciTech Connect

    James Longhurst

    2007-06-15

    Pittsburgh came to be - and came to be dirtybecause of location, location, and location. Two navigable rivers met in the middle of a forest, and combined to form a third river. This was an irresistible meeting point for settlement, trade, and industry. It was an added bonus that this meeting point was at the center of the 'Pittsburgh seam' of coal. While the natural advantages of geography and geology initiated development, Pittsburgh's growth soon attracted man-made transportation networks to import resources from its hinterland and spread finished materials through the Midwest. As the city boomed into an industrial metropolis - the Iron City, the Steel City - through the late 19th and early 20th centuries, the smoke only became worse, and Pittsburgh became known, nationally and even internationally, for its dirt, grime, and filth. For many of the city's workers and businessmen, smoke was a sign of progress and economic success. From small-scale iron production, to the process of refining coal into 'coke,' to the Bessemer steel process, to J.P. Morgan and Andrew Carnegie's creation of the vertically-integrated U.S. Steel corporation, to the pioneering use of 'byproduct' coke ovens, Pittsburgh was home to successive technologies for transforming raw materials into finished or refined goods. Pittsburgh is both singular and representative; its story is at the forefront of pollution history, but the forces, trends, and events the city witnessed were the same in many cities across the nation. So while it is true that A&WMA's headquarters are in Pittsburgh for a reason, it is also true that its membership is spread across the nation and the world. That membership will most likely find something in these four themes from Pittsburgh's history that is representative of their own study. 7 refs., 3 photos.

  6. PaR-PaR laboratory automation platform.

    PubMed

    Linshiz, Gregory; Stawski, Nina; Poust, Sean; Bi, Changhao; Keasling, Jay D; Hillson, Nathan J

    2013-05-17

    Labor-intensive multistep biological tasks, such as the construction and cloning of DNA molecules, are prime candidates for laboratory automation. Flexible and biology-friendly operation of robotic equipment is key to its successful integration in biological laboratories, and the efforts required to operate a robot must be much smaller than the alternative manual lab work. To achieve these goals, a simple high-level biology-friendly robot programming language is needed. We have developed and experimentally validated such a language: Programming a Robot (PaR-PaR). The syntax and compiler for the language are based on computer science principles and a deep understanding of biological workflows. PaR-PaR allows researchers to use liquid-handling robots effectively, enabling experiments that would not have been considered previously. After minimal training, a biologist can independently write complicated protocols for a robot within an hour. Adoption of PaR-PaR as a standard cross-platform language would enable hand-written or software-generated robotic protocols to be shared across laboratories.

  7. PaR-PaR Laboratory Automation Platform

    SciTech Connect

    Linshiz, G; Stawski, N; Poust, S; Bi, CH; Keasling, JD; Hilson, NJ

    2013-05-01

    Labor-intensive multistep biological tasks, such as the construction and cloning of DNA molecules, are prime candidates for laboratory automation. Flexible and biology-friendly operation of robotic equipment is key to its successful integration in biological laboratories, and the efforts required to operate a robot must be much smaller than the alternative manual lab work. To achieve these goals, a simple high-level biology-friendly robot programming language is needed. We have developed and experimentally validated such a language: Programming a Robot (PaR-PaR). The syntax and compiler for the language are based on computer science principles and a deep understanding of biological workflows. PaR-PaR allows researchers to use liquid-handling robots effectively, enabling experiments that would not have been considered previously. After minimal training, a biologist can independently write complicated protocols for a robot within an hour. Adoption of PaR-PaR as a standard cross-platform language would enable hand-written or software-generated robotic protocols to be shared across laboratories.

  8. Particulate Air Pollution and the Rate of Hospitalization for Congestive Heart Failure among Medicare Beneficiaries in Pittsburgh, Pennsylvania.

    PubMed Central

    Wellenius, Gregory A.; Bateson, Thomas F.; Mittleman, Murray A.; Schwartz., Joel

    2006-01-01

    We used a case-crossover approach to evaluate the association between ambient air pollution and the rate of hospitalization for congestive heart failure (CHF) among Medicare recipients (age ≥ 65) residing in Allegheny County (Pittsburgh area), PA, during 1987–1999. We also explored effect modification by age, gender, and specific secondary diagnoses. During follow-up, there were 55,019 admissions with a primary diagnosis of CHF. We found that particulate matter with aerodynamic diameter ≤ 10 μm (PM10), carbon monoxide (CO), nitrogen dioxide (NO2), and sulfur dioxide – but not ozone – were positively and significantly associated with the rate of admission on the same day in single-pollutant models. The strongest associations were observed with CO, NO2 and PM10. The associations with CO and NO2 were the most robust in two-pollutant models, remaining statistically significant even after adjusting for other pollutants. Patients with a recent myocardial infarction were at greater risk of particulate-related admission, but there was otherwise no significant effect modification by age, gender, or other secondary diagnoses. These results suggest that short-term elevations in air pollution from traffic-related sources may trigger acute cardiac decompensation of heart failure patients and that those with certain comorbid conditions may be more susceptible to these effects. PMID:15901623

  9. Can someone call my PA?

    PubMed

    Dowsing, T; Chellamuthu, P; Powell, N; Forbes-Pyman, R

    2014-01-01

    The aim of this paper is to outline the background of the Physician Associate (known in the USA as physician assistant¹) role in the USA and follow its recent journey to the UK where it is becoming a rapidly developing new healthcare role. Through the use of two case studies from UK Hospital Trusts who are currently utilising Physician Associates (PAs) in their workforce we describe the implementation and development opportunities for the role, with particular reference to their role in Acute Medicine teams of the future.

  10. The Power of Place: Social network characteristics, perceived neighborhood features, and psychological distress among African Americans in the historic Hill District in Pittsburgh, Pennsylvania

    PubMed Central

    Flórez, Karen R.; Ghosh-Dastidar, Madhumita (Bonnie); Beckman, Robin; de la Haye, Kayla; Duru, O. Kenrik; Abraído-Lanza, Ana F.; Dubowitz, Tamara

    2016-01-01

    African American neighborhoods have been historically targeted for urban renewal projects, which impact social composition and resident’s health. The Hill District in Pittsburgh, PA is such a neighborhood. This research sought to investigate the extent to which social networks and perceived neighborhood social cohesion and safety were associated with psychological distress among residents in an African American neighborhood undergoing urban renewal, before the implementation of major neighborhood changes. Findings revealed a modest, significant inverse association between social network size and psychological distress (β=−0.006, p<0.01), even after controlling for age, employment, education and income. Perceived neighborhood safety predicted decreased psychological distress (β=−1.438, p<0.01), but not social cohesion, which is consistent with past research. Findings suggest that social networks protect against psychological distress, but neighborhood perceptions are also paramount. PMID:27612324

  11. The Power of Place: Social Network Characteristics, Perceived Neighborhood Features, and Psychological Distress Among African Americans in the Historic Hill District in Pittsburgh, Pennsylvania.

    PubMed

    Flórez, Karen R; Ghosh-Dastidar, Madhumita Bonnie; Beckman, Robin; de la Haye, Kayla; Duru, Obidiugwu Kenrik; Abraído-Lanza, Ana F; Dubowitz, Tamara

    2016-09-01

    African American neighborhoods have been historically targeted for urban renewal projects, which impact social composition and resident's health. The Hill District in Pittsburgh, PA is such a neighborhood. This research sought to investigate the extent to which social networks and perceived neighborhood social cohesion and safety were associated with psychological distress among residents in an African American neighborhood undergoing urban renewal, before the implementation of major neighborhood changes. Findings revealed a modest, significant inverse association between social network size and psychological distress (β = -0.006, p < .01), even after controlling for age, employment, education, and income. Perceived neighborhood safety predicted decreased psychological distress (β = -1.438, p < .01), but not social cohesion, which is consistent with past research. Findings suggest that social networks protect against psychological distress, but neighborhood perceptions are also paramount. © Society for Community Research and Action 2016.

  12. Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation.

    PubMed

    Villeneuve, Sylvia; Rabinovici, Gil D; Cohn-Sheehy, Brendan I; Madison, Cindee; Ayakta, Nagehan; Ghosh, Pia M; La Joie, Renaud; Arthur-Bentil, Samia Kate; Vogel, Jacob W; Marks, Shawn M; Lehmann, Manja; Rosen, Howard J; Reed, Bruce; Olichney, John; Boxer, Adam L; Miller, Bruce L; Borys, Ewa; Jin, Lee-Way; Huang, Eric J; Grinberg, Lea T; DeCarli, Charles; Seeley, William W; Jagust, William

    2015-07-01

    Amyloid-β, a hallmark of Alzheimer's disease, begins accumulating up to two decades before the onset of dementia, and can be detected in vivo applying amyloid-β positron emission tomography tracers such as carbon-11-labelled Pittsburgh compound-B. A variety of thresholds have been applied in the literature to define Pittsburgh compound-B positron emission tomography positivity, but the ability of these thresholds to detect early amyloid-β deposition is unknown, and validation studies comparing Pittsburgh compound-B thresholds to post-mortem amyloid burden are lacking. In this study we first derived thresholds for amyloid positron emission tomography positivity using Pittsburgh compound-B positron emission tomography in 154 cognitively normal older adults with four complementary approaches: (i) reference values from a young control group aged between 20 and 30 years; (ii) a Gaussian mixture model that assigned each subject a probability of being amyloid-β-positive or amyloid-β-negative based on Pittsburgh compound-B index uptake; (iii) a k-means cluster approach that clustered subjects into amyloid-β-positive or amyloid-β-negative based on Pittsburgh compound-B uptake in different brain regions (features); and (iv) an iterative voxel-based analysis that further explored the spatial pattern of early amyloid-β positron emission tomography signal. Next, we tested the sensitivity and specificity of the derived thresholds in 50 individuals who underwent Pittsburgh compound-B positron emission tomography during life and brain autopsy (mean time positron emission tomography to autopsy 3.1 ± 1.8 years). Amyloid at autopsy was classified using Consortium to Establish a Registry for Alzheimer's Disease (CERAD) criteria, unadjusted for age. The analytic approaches yielded low thresholds (standard uptake value ratiolow = 1.21, distribution volume ratiolow = 1.08) that represent the earliest detectable Pittsburgh compound-B signal, as well as high thresholds (standard

  13. Meeting the Challenges of Multicultural Education. The Third Report from the Evaluation of Pittsburgh's Prospect Multicultural Education Center.

    ERIC Educational Resources Information Center

    Nettles, Saundra Murray; McHugh, Barbara; Gottfredson, Gary D.

    This is the third report from the evaluation of the Multicultural Education Program in Pittsburgh (Pennsylvania), a major effort to address racial and ethnic diversity in a middle school. Section 1 of the report provides background on the multicultural education movement and the aims of the Pittsburgh program. Section 2 describes the status of the…

  14. How Roebling did it: Building the world's first wire-rope suspension aqueduct in 1840s Pittsburgh

    NASA Astrophysics Data System (ADS)

    Gibbon, Donald L.

    2006-05-01

    The noted bridge designed John Roebling introduced his wire-rope suspension concept in Pittsburgh on a wooden aqueduct. His design was later implemented in bridges in Pittsburgh and elsewhere, including New York's Brooklyn Bridge. This article describes Roebling's work based on reviews of his notes and other historical documents.

  15. PaTH: towards a learning health system in the Mid-Atlantic region

    PubMed Central

    Amin, Waqas; Tsui, Fuchiang (Rich); Borromeo, Charles; Chuang, Cynthia H; Espino, Jeremy U; Ford, Daniel; Hwang, Wenke; Kapoor, Wishwa; Lehmann, Harold; Martich, G Daniel; Morton, Sally; Paranjape, Anuradha; Shirey, William; Sorensen, Aaron; Becich, Michael J; Hess, Rachel

    2014-01-01

    The PaTH (University of Pittsburgh/UPMC, Penn State College of Medicine, Temple University Hospital, and Johns Hopkins University) clinical data research network initiative is a collaborative effort among four academic health centers in the Mid-Atlantic region. PaTH will provide robust infrastructure to conduct research, explore clinical outcomes, link with biospecimens, and improve methods for sharing and analyzing data across our diverse populations. Our disease foci are idiopathic pulmonary fibrosis, atrial fibrillation, and obesity. The four network sites have extensive experience in using data from electronic health records and have devised robust methods for patient outreach and recruitment. The network will adopt best practices by using the open-source data-sharing tool, Informatics for Integrating Biology and the Bedside (i2b2), at each site to enhance data sharing using centrally defined common data elements, and will use the Shared Health Research Information Network (SHRINE) for distributed queries across the network. PMID:24821745

  16. Higher Education Sustainability in Pittsburgh: Highlights from the AASHE 2011 Campus Tours

    ERIC Educational Resources Information Center

    Srinivasamohan, Ashwini; Walton, Judy; Wagner, Margo

    2012-01-01

    This quote by ecologist, "Silent Spring" author and Chatham University alum Rachel Carson reminds us of the everyday tenacity needed in working to advance a sustainable and just world. This publication celebrates that tenacity in the higher education sector, specifically among institutions in the Pittsburgh area. Historically known for…

  17. 78 FR 22843 - Foreign-Trade Zone 33-Pittsburgh, Pennsylvania, Authorization of Export Production Activity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-17

    ... Production Activity, Tsudis Chocolate Company (Chocolate Confectionery Bars), Pittsburgh, Pennsylvania On December 4, 2012, Tsudis Chocolate Company, submitted a notification of proposed export production activity... liquid chocolate admitted to FTZ 33 must be re-exported. Dated: April 11, 2013. Andrew McGilvray...

  18. The Center on Race and Social Problems at the University of Pittsburgh

    ERIC Educational Resources Information Center

    Davis, Larry E.; Bangs, Ralph L.

    2007-01-01

    In 2002, the School of Social Work at the University of Pittsburgh established the Center on Race and Social Problems (CRSP). CRSP, which is the first race research center to be housed in a school of social work, has six foci: economic disparities; educational disparities; interracial group relations; mental health; youth, families, and elderly;…

  19. Pittsburgh Area Preschool Association Publication: Selected Articles (Volume 8, No. 1-4).

    ERIC Educational Resources Information Center

    Frank, Mary, Ed.

    This compilation of short reports distributed to preschool teachers in the Pittsburgh area covers four main topics: (1) Adoption (2) Expressive Art Therapy, (3) The Infant, and (4) Learning Disorders in Young Children. The adoption section includes reports pertaining to the adoption process in Pennsylvania, adoptive parents' legal rights, medical…

  20. Boundary Spanning in Homeless Children's Education: Notes from an Emergent Faculty Role in Pittsburgh

    ERIC Educational Resources Information Center

    Miller, Peter M.

    2009-01-01

    Purpose: This From the Field article describes an emerging model of boundary spanning leadership in homeless education. Drawing from the pilot program that is being implemented in conjunction with the Homeless Children's Education Fund in Pittsburgh, the article identifies areas of promise and potential limits to university faculty involvement…

  1. Processing the CONSOL Energy, Inc. Mine Maps and Records Collection at the University of Pittsburgh

    ERIC Educational Resources Information Center

    Rougeux, Debora A.

    2011-01-01

    This article describes the efforts of archivists and student assistants at the University of Pittsburgh's Archives Service Center to organize, describe, store, and provide timely and efficient access to over 8,000 maps of underground coal mines in southwestern Pennsylvania, as well the records that accompanied them, donated by CONSOL Energy, Inc.…

  2. Mapping Multiple Perspectives: Research Reports of the University of Pittsburgh Social Cartography Project, 1993-1996.

    ERIC Educational Resources Information Center

    Paulston, Rolland G.; And Others

    The Department of Administrative and Policy Studies (APS), University of Pittsburgh (Pennsylvania), completed six research reports about its Conceptual Mapping Project. The reports reproduced here originally appeared in the "Occasional Paper Series" of the APS. They are presented in order of the chronological appearance as follows: (1)…

  3. The Institutional Subordination of Contested Issues: The Case of Pittsburgh's Steelworkers and Ministers.

    ERIC Educational Resources Information Center

    McClure, Kevin R.

    1996-01-01

    Analyzes a case where a group of local steelworkers in the Pittsburgh, Pennsylvania area, in conjunction with a small group of Protestant ministers, sought to gain public support for the redress of grievances, and how their subordination by the United Steel Workers' union and the Lutheran Church influenced their rhetorical activities. (SR)

  4. Pittsburgh Board of Public Education Task Force on Adolescent Pregnancy and Parenting: Minority Report.

    ERIC Educational Resources Information Center

    Kaleida, Phillip; And Others

    This minority report is a rebuttal to the recommendations made by the Task Force on Adolescent Pregnancy and Parenting of the Pittsburgh Board of Public Education. It takes issue with the way in which decisions were made and especially with the recommendation to establish school-based clinics (SBCs) in or near high risk schools. This minority…

  5. Collaborative Intervention Approaches for At-Risk Youth: The Pittsburgh Experience.

    ERIC Educational Resources Information Center

    Denton, Stanley E.; Davis, Lawrence E.

    In 1987, the Board of Education of the Pittsburgh (Pennsylvania) Public Schools set goals for reducing the achievement gap between black students and white students and improving the educational outcomes of all low achievers, regardless of race. This paper summarizes programs, most involving parents, community leaders, and the corporate sector in…

  6. Transferring Academic Credits Among Different Institutions: An Example of Policy at the University of Pittsburgh.

    ERIC Educational Resources Information Center

    Kleppick, Annabelle L.; Hiller, Marc D.

    Current policies and practices governing the transfer of credit at the University of Pittsburgh were reviewed. Both the general policies of the university and the specific policies of the School of General Studies, the degree granting unit, were included for study. Consideration has been given to expediting the progress of mature adults through…

  7. Teacher Quality Roadmap: Improving Policies and Practices in Pittsburgh Public Schools

    ERIC Educational Resources Information Center

    Gonzalez, Angel; Kumar, Sudipti; Waymack, Nancy

    2014-01-01

    The Pittsburgh Public Schools study is the 12th district study since the National Council on Teacher Quality (NCTQ) began studying districts in-depth in 2009. The intent of these studies is to give select communities a comprehensive look at what is happening in their local school districts that may be either helping or hurting teacher quality, and…

  8. Higher Education Sustainability in Pittsburgh: Highlights from the AASHE 2011 Campus Tours

    ERIC Educational Resources Information Center

    Srinivasamohan, Ashwini; Walton, Judy; Wagner, Margo

    2012-01-01

    This quote by ecologist, "Silent Spring" author and Chatham University alum Rachel Carson reminds us of the everyday tenacity needed in working to advance a sustainable and just world. This publication celebrates that tenacity in the higher education sector, specifically among institutions in the Pittsburgh area. Historically known for…

  9. Framework for Collaboration: Integrating School and Human Services Data in Pittsburgh. OCD Special Report

    ERIC Educational Resources Information Center

    University of Pittsburgh Office of Child Development, 2011

    2011-01-01

    This Special Report discusses how the Allegheny County Department of Human Services and Pittsburgh Public Schools took a major step toward closing a knowledge gap that prevents schools and human service agencies around the country from developing a deeper understanding of the children in their systems and collaborating on more effective, better…

  10. The Nonprofit Clinic at the University of Pittsburgh: Preparing Students for Transition to Professional Settings

    ERIC Educational Resources Information Center

    Kearns, Kevin P.

    2014-01-01

    The Nonprofit Clinic at the University of Pittsburgh gives graduate students the opportunity to serve as management consultants to nonprofit organizations. This article describes the learning objectives, logistics, and outcomes of the Nonprofit Clinic. Bloom's 1956 taxonomy of learning objectives is employed to assess learning outcomes.

  11. The Use of Research Libraries: A Comment about the Pittsburgh Study and Its Critics.

    ERIC Educational Resources Information Center

    Peat, W. Leslie

    1981-01-01

    Reviews the controversy surrounding the Pittsburgh study of library circulation and collection usage and proposes the use of citation analysis techniques as an acceptable method for measuring research use of a research library which will complement circulation studies. Five references are listed. (RAA)

  12. Processing the CONSOL Energy, Inc. Mine Maps and Records Collection at the University of Pittsburgh

    ERIC Educational Resources Information Center

    Rougeux, Debora A.

    2011-01-01

    This article describes the efforts of archivists and student assistants at the University of Pittsburgh's Archives Service Center to organize, describe, store, and provide timely and efficient access to over 8,000 maps of underground coal mines in southwestern Pennsylvania, as well the records that accompanied them, donated by CONSOL Energy, Inc.…

  13. The Nonprofit Clinic at the University of Pittsburgh: Preparing Students for Transition to Professional Settings

    ERIC Educational Resources Information Center

    Kearns, Kevin P.

    2014-01-01

    The Nonprofit Clinic at the University of Pittsburgh gives graduate students the opportunity to serve as management consultants to nonprofit organizations. This article describes the learning objectives, logistics, and outcomes of the Nonprofit Clinic. Bloom's 1956 taxonomy of learning objectives is employed to assess learning outcomes.

  14. THE LIBERTY ELEMENTARY SCHOOL, NEW LIFE FOR OLD SCHOOLS. PITTSBURGH DESIGN STUDY.

    ERIC Educational Resources Information Center

    Great Cities Research Council, Chicago, IL.

    A STUDY OF AN OLD SCHOOL BUILDING AND ITS NEIGHBORHOOD IS REPORTED, INCLUDING A DESCRIPTION OF EACH. A DESCRIPTION OF PITTSBURGH MASTER PLANS FOR ACHIEVING EDUCATIONAL EXCELLENCE AND RACIAL AND CULTURAL INTEGRATION INTRODUCES THE PAPER. URBAN DESIGN SOLUTIONS FOR THE NEIGHBORHOOD INCLUDE DISCUSSIONS OF NEW HOUSING, TRAFFIC CIRCULATION, PARKING…

  15. Education, Employment, and the Economy. An Examination of Work-Related Education in Greater Pittsburgh.

    ERIC Educational Resources Information Center

    Glennan, Thomas K., Jr.; And Others

    A study described Pittsburgh's education and training system for producing skilled and semiskilled workers and sought to identify challenges that the system will face as the area's economy strives for increased vitality. The study addressed multiple education and training functions, including preparing youth for productive careers, supporting the…

  16. The Center on Race and Social Problems at the University of Pittsburgh

    ERIC Educational Resources Information Center

    Davis, Larry E.; Bangs, Ralph L.

    2007-01-01

    In 2002, the School of Social Work at the University of Pittsburgh established the Center on Race and Social Problems (CRSP). CRSP, which is the first race research center to be housed in a school of social work, has six foci: economic disparities; educational disparities; interracial group relations; mental health; youth, families, and elderly;…

  17. Beyond Pittsburgh: protocols for controlled non-heart-beating cadaver organ recovery.

    PubMed

    Spielman, B; McCarthy, C S

    1995-12-01

    Much of the ethical debate about controlled non-heart-beating cadaver (NHBC) organ recovery has focused on the University of Pittsburgh Medical Center (UPMC) protocol. Some commentators have voiced serious reservations about the ethical acceptability of that protocol; others have argued that the protocol contains sufficiently stringent ethical safeguards to warrant a limited and carefully monitored trial at UPMC. UPMC is not the only organization pursuing controlled NHBC organ procurement, however. The study of organ procurement organizations described in this article suggests that controlled NHBC organ procurement is a practice that, if not yet widespread, is certainly no longer isolated to a few organizations in which it is carefully monitored. Rather, it is being carried out under a variety of circumstances, many of which are less carefully constrained ethically than at the University of Pittsburgh Medical Center. The next stage of the ethical debate should focus on issues that are arising in a variety of settings as the practice spreads.

  18. The Pittsburgh Oral-Facial Cleft study: expanding the cleft phenotype. Background and justification.

    PubMed

    Weinberg, Seth M; Neiswanger, Katherine; Martin, Rick A; Mooney, Mark P; Kane, Alex A; Wenger, Sharon L; Losee, Joseph; Deleyiannis, Frederick; Ma, Lian; De Salamanca, Javier E; Czeizel, Andrew E; Marazita, Mary L

    2006-01-01

    The Pittsburgh Oral-Facial Cleft study was begun in 1993 with the primary goal of identifying genes involved in nonsyndromic orofacial clefts in a variety of populations worldwide. Based on the results from a number of pilot studies and preliminary genetic analyses, a new research focus was added to the Pittsburgh Oral-Facial Cleft study in 1999: to elucidate the role that associated phenotypic features play in the familial transmission patterns of orofacial clefts in order to expand the definition of the nonsyndromic cleft phenotype. The purpose of this paper is to provide a comprehensive review of phenotypic features associated with nonsyndromic orofacial clefts. These features include fluctuating and directional asymmetry, non-right-handedness, dermatoglyphic patterns, craniofacial morphology, orbicularis oris muscle defects, dental anomalies, structural brain and vertebral anomalies, minor physical anomalies, and velopharyngeal incompetence.

  19. A Description of the Building Materials Data Base for Pittsburgh, Pennsylvania.

    DTIC Science & Technology

    1986-04-01

    The 21 material types grouped into five material types. APAINT Painted wood (excl. stained) Painted steel Painted aluminum Painted masonry Painted...skylights was observed in Pittsburgh. It had 10 skylights (ITEM2, SKYM), made of bare aluminum . . Six buildings with flashing material, FLMAlT, were...identifly0 46 Sloped’ c flat’ ___- ___ Surface a e" (sq 1t)- ROOF-MOUNTED APPARATUS Vents, flues, and stacks: painted,’ bare galvanized,’ bare aluminum

  20. U.S. Army Corps of Engineers Civil Works Pittsburgh District Recovery Act Implementation

    DTIC Science & Technology

    2010-09-30

    Brief: Audit of the U.S. Army Corps of Engineers Civil Works Pittsburgh District Recovery Act Implementation What We Did Our objective was to...09-15, “Updated Implementing Guidance for the American Recovery and Reinvestment Act of 2009,” April 3, 2009. Specifically, our objective was to... Creek Lake, and Upper Ohio Navigation Study. The three projects had several planned or already awarded contracts funded under the Recovery Act

  1. New Whole-House Solutions Case Study: Evaluating Through-Wall Air Transfer Fans, Pittsburgh, Pennsylvania

    SciTech Connect

    2014-10-01

    In this project, Building America team IBACOS performed field testing in a new construction unoccupied test house in Pittsburgh, Pennsylvania, to evaluate heating, ventilating, and air conditioning (HVAC) distribution systems during heating, cooling, and midseason conditions. The team evaluated a market-available through-wall air transfer fan system that provides air to the bedrooms.The relative ability of this system was considered with respect to relevant Air Conditioning Contractors of America and ASHRAE standards for house temperature uniformity and stability.

  2. Environmental Assessment of Proposed Wing Headquarters Facility at Pittsburgh International Airport Air Reserve Station, Pennsylvania

    DTIC Science & Technology

    2005-03-01

    meter MSC Medium specific concentrations MSW municipal solid waste MS4 municipal separate storm sewer systems NAAQS National Ambient Air Quality...achieve a level of water quality that provides for the protection and propagation of fish, shellfish , and wildlife; and recreation in and on the water...Township Municipal Authority’s sanitary sewer lines and sewage treatment facility. Pittsburgh IAP ARS’ wastewater is carried off base via one 15-inch sewer

  3. Environmental Assessment of Proposed Wing Headquarters Facility at Pittsburgh International Airport Air Reserve Station, Pennsylvania

    DTIC Science & Technology

    2005-05-24

    paint LEED Leadership in Energy & Environmental Design mBtu million British Thermal Units mg/m3 milligrams per cubic meter MSC Medium specific...quality that provides for the protection and propagation of fish, shellfish , and wildlife; and recreation in and on the water. Executive Order (EO) 11988...sanitary sewer lines and sewage treatment facility. Pittsburgh IAP ARS’ wastewater is carried off base via one 15-inch sewer main, which runs along the

  4. Urban hydrology in a rugged, old place: emerging lessons from Pittsburgh (Invited)

    NASA Astrophysics Data System (ADS)

    Bain, D. J.; Hopkins, K. G.; Pfeil McCullough, E. K.

    2013-12-01

    Cities on rugged landscapes mantled by clay-rich soils are rare, and therefore under-characterized, despite the rich challenges in the management of coupled human-hydrologic systems. Pittsburgh, Pennsylvania inherits a high relief landscape imparted by mega-drainage following the last glacial maximum. Since European occupation, and throughout the growth of Pittsburgh, simply finding sufficient flat areas to inhabit have led to radical changes to the landscape with clear implications for hydrological function. Over the last several years, examination of these coupled topographical-hydrological changes with particular attention to reconstruction of historical processes has revealed interesting dynamics. In particular, the tendency to utilize flat ridgelines has created fluvial systems with unusual burial pattens in Pittsburgh. This burial exacerbates changes to urban hydrographs and likely requires extensive engineering in the uplands to re-establish sustainable flow regimes, challenges that will grow as urban re-population processes continue and urban lands grow scarcer. Further, these historical patterns of development can create negative feedbacks to the human-hydrologic system during natural disturbances of forest, as intact forests are disproportionately located on steep slopes. Additionally, both the use of available fill materials to flatten the landscape and changes to riparian geomorphology resulting from increased sediment supplies impart structural legacies to the system resulting in unexpected changes to surface water chemistry. Continued examination and synthesis of interactions between landscape modification and hydrology in Pittsburgh will ultimately characterize an important end-member of urban systems, providing clarity in our efforts to manage urban human-hydrological systems.

  5. Pittsburgh Regional Healthcare Initiative puts new spin on improving healthcare quality.

    PubMed

    2002-11-01

    For nearly 4 years, the Pittsburgh Regional Healthcare Initiative (PRHI) has been working to improve the way healthcare is delivered in southwestern Pennsylvania by combining the voices and resources of hospitals, providers, the business community, insurers, health plans, and federal agencies. As one example of borrowing from business, the PRHI has created a new learning and management system, called Perfecting Patient Care, which is based on the Toyota Production System model and is now being used successfully in hospitals.

  6. Environmental assessment report for proposed wastewater treatment facility at the Pittsburgh Energy Technology Center. Final report

    SciTech Connect

    Not Available

    1981-07-01

    A proposed wastewater treatment facility is to be constructed at the US Department of Energy's Pittsburgh Energy Technology Center (PETC). The facility consists of three parts (water treatment plant, south pump station, and north pump station) and is to be constructed in three areas. The facility is designed to treat surface runoff from PETC before it washes into Lick Run. Legal ramifications and environmental consequences are discussed.

  7. Does a positive Pittsburgh Compound B scan in a patient with dementia equal Alzheimer disease?

    PubMed

    Ducharme, Simon; Guiot, Marie-Christine; Nikelski, James; Chertkow, Howard

    2013-07-01

    The clinical role of amyloid brain positron emission tomographic imaging in the diagnosis of Alzheimer disease is currently being formulated. The specificity of a positive amyloid scan is a matter of contention. An 83-year-old Canadian man presented with a 5-year history of predominantly short-term memory loss and functional impairment. Clinical evaluation revealed significant, gradually progressive short-term memory loss in the absence of any history of strokes or other neuropsychiatric symptoms. The patient met clinical criteria for probable Alzheimer disease but had a higher than expected burden of white matter disease on magnetic resonance imaging. A positron emission tomographic Pittsburgh Compound B scan was highly positive in typical Alzheimer disease distribution. The patient died of an intracerebral hemorrhage 6 months after the assessment. Autopsy revealed cerebral amyloid angiopathy in the complete absence of amyloid plaques or neurofibrillary tangles. This patient demonstrates that a positive Pittsburgh Compound B scan in a patient with clinical dementia meeting criteria for probable Alzheimer disease is not proof of an Alzheimer disease pathophysiological process. A positive Pittsburgh Compound B scan in typical Alzheimer disease distribution in a patient with dementia can be secondary to cerebral amyloid angiopathy alone.

  8. National Dam Inspection Program. Crabapple Dam (NDI Number PA 00907, PennDER Number 26-32) Ohio River Basin, Crabapple Run, Fayette County, Pennsylvania. Phase I Inspection Report,

    DTIC Science & Technology

    1980-07-01

    7 D-A091 529 ACKENHEIL AND ASSOCIATES INC PITTSBURGH PA F/6 13/13 NATIONAL DAM INSPECTION PROGRAM. CRABAPPLE DAM (NDI NUMBER PA 0-ETC(U) JUL B8 J P...HANNAN, J E BARRICK DAC 31- BOC-0026 UNCLASSIFIE NLE2IIIIIIIhIIIl EIIIIIIIIIIIII 0OHI0 RIVER BASIN CRABAPPLE RUN FAYETTE COUNTY PENNSYLVANIA NDI No. PA...00907 :E- 1rŘ PENN DER No. 26-32 me CRABAPPLE DAM STEPHEN VINCINSKI and GEORGE THOMAS PHASE I INSPECTION REPORT NATIONAL DAM INSPECTION PROGRAM J 1

  9. Air Quality from Early Pittsburgh to the Present: The Science of Change

    NASA Astrophysics Data System (ADS)

    Davidson, Cliff

    2009-03-01

    Throughout Pittsburgh's history over the past 250 years, coal reserves in the city and nearby have influenced its economy, demographics, and environmental quality. They have also played a major role in determining air quality in the region. For example, Pittsburgh became famous for its high particle loadings as early as the beginning of the nineteenth century, when the first complaints about air quality in the city were recorded. Nevertheless, residents tolerated the high coal smoke levels since jobs depended on the iron works, steel mills, and other industries. When natural gas was discovered just east of the city in the 1870's and replaced coal for some applications, particle concentrations decreased. But the local supplies of natural gas ran short several years later, and as industry continued to expand in the 1890's the city went back to the use of coal as its primary fuel. The return to smoky air was met with resistance that marked the beginning of sustained public outcry and initiation of several air pollution studies. The next half century was marked by periods of occasional high and low concentration, the latter due to events such as the financial panic of 1907 and the depression of the 1930's. It was not until the 1940's that effective regulations were passed to reduce smoky conditions. Particle levels fell throughout the 1950's and 1960's, and eventually the decline of heavy industry in Pittsburgh led to relatively clean air in many parts of the city. Over the past few decades, airborne particle concentrations averaged across the Pittsburgh region have remained below their earlier levels. However, there are still ``hot spots'' of high concentration resulting from regional background coming from upwind areas and emissions of some large sources that have continued to operate in the Pittsburgh region. Furthermore, the composition of airborne particles in the city has changed from earlier times. Such particles are now the result of emissions from sources in

  10. Nine Radar Images of Asteroid PA8

    NASA Image and Video Library

    2012-11-26

    Images of asteroid 2007 PA8 have been generated with data collected by NASA Goldstone Solar System Radar. The images of 2007 PA8 reveal possible craters, boulders, an irregular, asymmetric shape, and very slow rotation.

  11. The relationship between the University of Pittsburgh School of Medicine and the University of Pittsburgh Medical Center--a profile in synergy.

    PubMed

    Levine, Arthur S; Detre, Thomas P; McDonald, Margaret C; Roth, Loren H; Huber, George A; Brignano, Mary Germann; Danoff, Sandra N; Farner, David M; Masnick, Jeffrey L; Romoff, Jeffrey A

    2008-09-01

    In the synergistic evolution of their research, educational, and clinical programs, the University of Pittsburgh (Pitt) School of Medicine (SOM) and the University of Pittsburgh Medical Center (UPMC) have followed one core principle: What is good for one is good for both. The collaboration is underpinned by UPMC's commitment to its community mission, including support for the academic and research objectives of the SOM. UPMC's conceptual origin was fostered by its experience with Western Psychiatric Institute and Clinic in the 1970s. Over time, UPMC acquired other hospitals through merger and negotiation and, by 2008, had grown into a $7 billion global health enterprise. From the outset, the senior leaders of both UPMC and Pitt committed to collaborative decision making on all key issues. Under this coordinated decision-making model, UPMC oversees all clinical activity, including that from a consolidated physicians' practice plan. Pitt remains the guardian of all academic priorities, particularly faculty-based research. UPMC's steady financial success underpins the model. A series of interrelated agreements formally defines the relationship between Pitt and UPMC, including shared board seats and UPMC's committed ongoing financial support of the SOM. In addition, the two institutions have jointly made research growth a priority. The payoff from this dynamic has been a steadily growing Pitt research portfolio; enhanced growth, visibility, and stature for UPMC, the SOM, and Pitt as a whole; and the sustained success of UPMC's clinical enterprise, which now has an international scope. Given the current stagnation in the National Institutes of Health budget, the Pitt-UPMC experience may be instructive to other academic health centers.

  12. ETV STATEMENT - PHYSICAL REMOVAL OF CRYPTOSPORIDIUM OOCYSTS AND GIARDIA CYSTS IN DRINKING WATER - ZENON ZEEWEED ZW500 ULTRAFILTRATION MEMBRANE SYSTEM AT PITTSBURGH, PA

    EPA Science Inventory

    Verification testing of the ZENON Environmental Inc. ZeeWeed ZW500 UF Drinking Water System was conducted from 2/6-3/7/99. The treatment system underwent Giardia and Cryptosporidium removal challenge testing on 3/2/99 and demonstrated a 5.3 log10 removal of Giardia cysts and a 6...

  13. Bridges to the Future: Building Linkages for Institutional Research. North East Association for Institutional Research Annual Conference Proceedings (27th, Pittsburgh, PA, November 4-7, 2000).

    ERIC Educational Resources Information Center

    North East Association for Institutional Research.

    This document contains papers, summaries of panel presentations, and work share meetings from the annual conference of the North East Association for Institutional Research. The papers are: (1) "The Influence of Personality Traits, Pre-College Characteristics, and Co-Curricular Experiences on College Outcomes" (Karen W. Bauer); (2)…

  14. ETV STATEMENT - PHYSICAL REMOVAL OF CRYPTOSPORIDIUM OOCYSTS AND GIARDIA CYSTS IN DRINKING WATER - ZENON ZEEWEED ZW500 ULTRAFILTRATION MEMBRANE SYSTEM AT PITTSBURGH, PA

    EPA Science Inventory

    Verification testing of the ZENON Environmental Inc. ZeeWeed ZW500 UF Drinking Water System was conducted from 2/6-3/7/99. The treatment system underwent Giardia and Cryptosporidium removal challenge testing on 3/2/99 and demonstrated a 5.3 log10 removal of Giardia cysts and a 6...

  15. Creating New Meanings in Leading Learning. Proceedings [of the] National Conference on Alternative and External Degree Programs for Adults (22nd, Pittsburgh, PA, October 9-12, 2002).

    ERIC Educational Resources Information Center

    American Council on Education, Washington, DC.

    These proceedings are comprised of 25 presentations divided into 5 "tracks." Section I, Diversity and Social Justice, has "Free to Learn with Body and Soul Jazz Divas, Beat Poets, and Street Preachers" (Ferrante, Belcastro); "Clashing Cultures in Our Classrooms" (Gabrich, Rothenberger); "Encouraging Adults in…

  16. Developments in experimental techniques in heat transfer and combustion; Proceedings of the Twenty-fourth National Heat Transfer Conference and Exhibition, Pittsburgh, PA, Aug. 9-12, 1987

    NASA Astrophysics Data System (ADS)

    Warrington, R. O., Jr.; Chen, M. M.; Felske, J. D.; Grosshandler, W. L.

    1987-08-01

    This volume includes articles related to the developments in experimental techniques in heat transfer and in combustion. Papers are presented on high-resolution heat-transfer-coefficient maps applicable to compound-curve surfaces using liquid crystals in a transient wind tunnel, an instrument for the measurement of the heat flux distribution along a contour of a surface at uniform temperature, an advanced viscometric thermometer for steady and unsteady states temperature measurement in electric or magnetic fields, the development of a thermopile-based deposition sensor, and the measurement of surface heat flux, using the Peltier effect. Consideration is also given to a new method of experimentally determining heat transfer coefficients in direct-contact bubble evaporation, temperature measurements by light scattering methods, the design calibration and error analysis of instrumentation for heat transfer in internal combustion, the application of an electrodynamic balance to study mass transfer from a single particle, single droplet studies in a hot high-pressure environment, and the measurement of flame propagation through a moving mixture.

  17. Measurements of Natural Radioactivity in Submicron Aerosols in the Pittsburgh Area.

    NASA Astrophysics Data System (ADS)

    Marley, N.; Gaffney, J. S.

    2002-12-01

    Natural radionuclides can be useful in evaluating the transport of ozone and aerosols in the troposphere. We have used natural radioactivity to estimate apparent residence times for submicron aerosols in the troposphere by looking at the disequilibrium of lead-210 with its daughters bismuth-210 (5-day half-life) and polonium-210 (138-day half-life). We have also measured the activity of beryllium-7 on fine aerosols to examine potential upper-air transport into the tropospheric boundary layer. Two sites in the Pittsburgh area during the summer of 2001 were sampled for beryllium-7, lead-210, bismuth-210, and polonium-210 on fine aerosols by using a Sierra Impactor (Stage 4) that allowed a nominal 1-micrometer cutoff diameter. One site was located approximately 5 km east of downtown Pittsburgh, on a rooftop next to Schenley Park (40.4395o N latitude and 79.9405o W longitude, elevation 310 m). A second site was located at the U.S. Department of Energy National Energy Technology Laboratory (NETL) Ambient Air Monitoring Station, approximately 15 km south of downtown Pittsburgh (40.30655 deg N latitude and 79.9794 deg W longitude, elevation 325 m). At both sites, 24-hour samples were collected from July 22 to July 30, 2001. Nine samples were taken at the NETL site, and six were taken at the Schenley Park site. The method for determining the lead-210 and its daughters will be described briefly. Apparent residence times ranged from 10-46 days, with an average of 23 days. Data indicate that little wind-blown soil or dust affected the area during the study. The importance of fine aerosol transport will be emphasized. The authors wish to thank Donald Martello of the NETL and Natalie J. Anderson of Carnegie Mellon University for sample collection. This work was supported by the United States Department of Energy, Atmospheric Chemistry Program.

  18. Indoor allergen sensitization and the risk of asthma and eczema in children in Pittsburgh.

    PubMed

    McHugh, Brook M; MacGinnitie, Andrew J

    2011-01-01

    Several studies have shown that sensitization to cockroach and mouse allergens is correlated with presence and severity of asthma, especially among children living in inner cities. This study evaluated the prevalence of positive skin testing to indoor allergens in the Pittsburgh area and the association with asthma and eczema. A retrospective analysis was performed of 540 children from the Pittsburgh area who underwent skin testing to indoor allergens. Presence of asthma and eczema were determined by parent and/or physician report. Asthma and eczema are not significantly more frequent among children who had positive skin testing to cockroaches or mice. However, asthma was more common among children who had positive skin testing to dogs (odds ratio [OR], 1.4; 95% CI, 1.23-1.65), cats (OR, 1.4; 95% CI, 1.21-1.58), and dust mites (OR, 1.2; 95% CI, 1.03-1.37). Eczema was more common in children who had positive skin testing to cats (OR, 1.5; 95% CI, 1.14-2.02). Both asthma (OR, 1.4; 95% CI, 1.18-1.58) and eczema (OR, 1.4; 95% CI, 1.07-1.92) were more prevalent among children with any positive skin test. We did not find that sensitization to cockroaches or mice was correlated with the diagnosis or asthma or eczema in the Pittsburgh area. However, sensitization to any allergen, and to cats and/or dogs specifically, was associated with diagnosis of both asthma and eczema. Our result suggests that allergic sensitization is associated with these diseases, but the implicated allergens may vary.

  19. Building America Case Study: Evaluating Through-Wall Air Transfer Fans, Pittsburgh, Pennsylvania (Fact Sheet)

    SciTech Connect

    Not Available

    2014-10-01

    In this project, Building America team IBACOS performed field testing in a new construction unoccupied test house in Pittsburgh, Pennsylvania to evaluate heating, ventilating, and air conditioning (HVAC) distribution systems during heating, cooling, and midseason conditions. Four air-based HVAC distribution systems were assessed:-a typical airflow ducted system to the bedrooms, a low airflow ducted system to the bedrooms, a system with transfer fans to the bedrooms, and a system with no ductwork to the bedrooms. The relative ability of each system was considered with respect to relevant Air Conditioning Contractors of America and ASHRAE standards for house temperature uniformity and stability, respectively.

  20. Reclaim Northside: An Environmental Justice Approach to Address Vacant Land in Pittsburgh.

    PubMed

    Teixeira, Samantha; Sing, Evaine

    2016-01-01

    Urban decline, disinvestment, and blight have not traditionally been addressed by the environmental conservation movement. In this article, we describe an environmental justice-focused intervention located in Pittsburgh, Pennsylvania, that aimed to increase community empowerment to address urban environmental injustices by training residents to reclaim vacant land. We use a case study approach to illustrate resident perceptions of the impact of vacant land and urban decay. The results suggest that these residents viewed vacancy as an important indicator of community well-being and social inequality. We use a social and environmental justice framework to describe results and implications for practitioners and researchers.

  1. Coal reserves of the Pittsburgh (No.8) bed in Belmont County, Ohio

    USGS Publications Warehouse

    Berryhill, Henry L.

    1955-01-01

    Remaining coal reserves totaling 1,929 million tons have been appraised in the Pittsburgh (No. 8) coal bed in Belmont County, Ohio. Of these, 508 million tons are classified as measured and 1,421 million tons are classified as indicated. All the coal has less than 1,000 feet of overburden, and most of it is of high volatile A bituminous rank. This estimate is based on field work by the United States Geological Survey, supplemented by data from the fries of the Ohio Geological Survey and from mine and drill-hole records provided by mining companies.

  2. Improved wastewater treatment at Wheeling-Pittsburgh Steel Corporations`s Steubenville East Coke Plant

    SciTech Connect

    Goshe, A.J.; Nodianos, M.J.

    1995-12-01

    Wheeling-Pittsburgh Steel Corporation recently improved its wastewater treatment at it`s by-products coke plant. This has led to greatly improved effluent quality. Excess ammonia liquor, along with wastewater from the light oil recovery plant, desulfurization facility, and coal pile runoff, must be treated prior to being discharged into the Ohio River. This is accomplished using a biological wastewater treatment plant to remove 99.99% of the organic contaminants and ammonia. Biologically treated, clarified wastewater is now polished in the newly constructed tertiary treatment plant.

  3. X-rays for Acute Knee Injuries: Pre- and Post- Pittsburgh Decision Rules Implementation. A District General Hospital Experience.

    PubMed

    El Ashry, Saad R; El Gamal, Tarek A; Challagundla, Sudhakar R; Ntala, Chara A; Nagy, Ahmed M; Crane, Evan O

    2016-10-28

    We wanted to assess the number of unnecessary radiographs done for acute knee injury patients and the accuracy of the Pittsburgh decision rules. A retrospective observational study was done to look at the acute knee injury patients presented to a district general hospital Accident and Emergency Department from August 2011 till August 2013. We assessed the following parameters: sex, age, mechanism of injury, weight-bearing status and incidence of fractures in patients subjected to plain radiograph. A prospective study was then done from April 2014- August 2014 following implementation of the Pittsburgh decision rules. 24% of the patients had knee X-ray, compared to 72.12% in the first cycle. 36.8% had fracture, compared to 6.1% first cycle, with 66.7 % reduction in x-rays. Pittsburgh decision rules sensitivity was 100% and specificity 85.3%, positive predictive value 45.8% and accuracy 87%. 1. The Pittsburgh decision rules is highly sensitive, specific and accurate in determining the need of X-ray in acute knee Injuries. 2. We found that the Pittsburgh decision rules performs well in our hospital, which coincides with previously published literature.

  4. Elements related to attrition of women faculty at the University of Pittsburgh, School of Medicine: A case study

    NASA Astrophysics Data System (ADS)

    Gandhi, Pooja

    Recent studies have shown that the number of women faculty in academic medicine is much lesser than the number of women that are graduating from medical schools. Many academic institutes face the challenge of retaining talented faculty and this attrition from academic medicine prevents career advancement of women faculty. This case study attempts to identify some of the reasons for dissatisfaction that may be related to the attrition of women medical faculty at the University of Pittsburgh, School of Medicine. Data was collected using a job satisfaction survey, which consisted of various constructs that are part of a faculty's job and proxy measures to gather the faculty's intent to leave their current position at the University of Pittsburgh or academic medicine in general. The survey results showed that although women faculty were satisfied with their job at the University of Pittsburgh, there are some important factors that influenced their decision of potentially dropping out. The main reasons cited by the women faculty were related to funding pressures, work-life balance, mentoring of junior faculty and the amount of time spent on clinical responsibilities. The analysis of proxy measures showed that if women faculty decided to leave University of Pittsburgh, it would most probably be due to better opportunity elsewhere followed by pressure to get funding. The results of this study aim to provide the School of Medicine at the University of Pittsburgh with information related to attrition of its women faculty and provide suggestions for implications for policy to retain their women faculty.

  5. Evaluation of Sleep Quality in Patients With Nasal Septal Deviation via the Pittsburgh Sleep Quality Index.

    PubMed

    Kara, Medine; Erdoğan, Halil; Güçlü, Oğuz; Sahin, Hasan; Dereköy, Fevzi Sefa

    2016-10-01

    To investigate the effect of nasal septum deviation, without obstructive sleep apnea, on sleep quality. The present case-controlled study enrolled patients older than 16 years with nasal septum deviation who attended the Otorhinolaryngology Clinic between December 2013 and July 2014. The control group was selected from patients attending the clinic for another complaint. Sleep quality was evaluated via the Pittsburgh Sleep Quality Index, and differences between the groups were compared using the Mann-Whitney U test. During the study period, 55 patients with nasal septum deviation were included in the study group, and the control group consisted of 51 patients with no complaints of nasal obstruction. Compared with the control group, patients with nasal septum deviation were found to be significantly higher (P <0.05) in all parameters of Pittsburgh Sleep Quality Index. The presence of nasal septum deviation with nasal obstruction should be investigated in patients with sleep disorders. If any pathology is present, opening the nasal passages should be ensured and sleep disorders reevaluated.

  6. Pest status of the brown marmorated stink bug, Halyomorpha halys (Stal) in the USA

    USDA-ARS?s Scientific Manuscript database

    Since its initial discovery in Allentown, PA, USA, the brown marmorated stink bug (BMSB), Halyomorpha halys (Heteroptera: Pentatomidae), has now officially been detected in 37 states and the District of Columbia in the USA. Isolated populations also exist in Switzerland and Canada. This Asian spec...

  7. Rely-Guarantee Protocols

    DTIC Science & Technology

    2014-05-01

    University Pittsburgh, PA 15213 1School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA. 2Faculdade de Ciências e Tecnologia ...additional examples that are not in the ECOOP paper. This work was partially supported by Fundação para a Ciência e Tecnologia (Portuguese Foundation

  8. Classification of contour deformities after massive weight loss: the applicability of the Pittsburgh Rating Scale in The Netherlands.

    PubMed

    van der Beek, E S J; Verveld, C J; van Ramshorst, B; Kon, M; Mink van der Molen, A B

    2013-08-01

    The Pittsburgh Rating Scale is the only validated classification system of skin deformities occurring after massive weight loss. The purpose of this study was to replicate the validation of the Pittsburgh Rating Scale classification and to evaluate its usefulness in the treatment of massive weight-loss patients in The Netherlands. Thirteen trained observers applied the Pittsburgh Rating Scale to photographs of 25 patients. These photographs showed the 10 regions of the body for which the Pittsburgh Rating Scale is designed. Six of the observers were medical specialists, three were medical interns in plastic surgery and four observers were specialised nurse practitioners. As a measure of inter-rater agreement we calculated the intraclass correlation with a threshold value of 0.6 for good validity. The observers also answered 11 questions about the scale's usefulness in daily practice. In two consecutive tests the photographs of 10 regions were scored, which resulted in a total of 20 observations per patient. Sixty percent of the intraclass correlation values were below the threshold of 0.6 for good validity. The mean intraclass correlation value was 0.577. The Pittsburgh Rating Scale could not be validated as a reliable classification system for skin deformities after massive weight loss. The scale however seems to be a good first step in a challenging task. There was no doubt among the observers that a good classification system would be beneficial for adequate treatment. A modified Pittsburgh Rating Scale should include, besides anatomical parameters, functional disability and hygienic impairment scores and perioperative risk factors. Copyright © 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

  9. View of hammer nameplate (Chambersburg Engineering Company, Chambersburg, Penna USA) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of hammer nameplate (Chambersburg Engineering Company, Chambersburg, Penna USA) and view north of Tony Talotta (heavy forger), Paul Azcharka (hammer operator), and Morty Hoffman (hammer operator helper) forging eyebolts. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Structure Shop, League Island, Philadelphia, Philadelphia County, PA

  10. 75 FR 69468 - Metlife Moosic, PA, Metlife Clarks Summit, PA; Notice of Affirmative Determination Regarding...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Metlife Moosic, PA, Metlife Clarks Summit, PA; Notice of Affirmative Determination Regarding Application for Reconsideration By application dated August 2, 2010, the...

  11. RIVERBANK AND MEADOW, LOOKING SOUTHEAST. PA148 AND PA149 CAN BE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    RIVERBANK AND MEADOW, LOOKING SOUTHEAST. PA-1-48 AND PA-1-49 CAN BE PAIRED TO FORM A PANORAMA SHOWING THE RELATIONSHIP BETWEEN THE RIVERBANK AND THE MEADOW - John Bartram House & Garden, 54th Street & Lindbergh Boulevard, Philadelphia, Philadelphia County, PA

  12. 1997 environmental monitoring report for the Bettis Atomic Power Laboratory, Pittsburgh Site

    SciTech Connect

    1997-12-31

    The 1997 results for the Bettis-Pittsburgh radiological and nonradiological environmental monitoring programs are presented. The results demonstrate that the existing procedures ensured that releases to the environment during 1997 were in accordance with applicable Federal, State, County, and local regulations. Evaluation of the environmental data indicates tat current operations at the Site continue to have no adverse effect on human health and the quality of the environment. A conservative assessment of radiation exposure to the general public as a result of Site operations demonstrates that the dose received by any member of the public was well below the most restrictive dose limits established by the Environmental Protection Agency, the Nuclear Regulatory Commission, and the US Department of Energy. A risk assessment of potentially exposed populations to chemical residues in the environment at the Site demonstrates that these residues do not pose any significant risk to human health or the environment.

  13. 2003 Environmental Monitoring Report for the Bettis Atomic Power Laboratory Pittsburgh Site

    SciTech Connect

    2003-12-31

    The 2003 results for the Bettis-Pittsburgh radiological and nonradiological environmental monitoring programs are presented. The results demonstrate that the existing procedures ensured that releases to the environment during 2003 were in accordance with applicable Federal, State, County, and local regulations. Evaluation of the environmental data indicates that current operations at the Site continue to have no adverse effect on human health and the quality of the environment. A conservative assessment of radiation exposure to the general public as a result of Site operations demonstrates that the dose received by any member of the public was well below the most restrictive dose limits established by the Environmental Protection Agency, the Nuclear Regulatory Commission, and the U.S. Department of Energy. A risk assessment of potentially exposed populations to chemical residues in the environment at the Site demonstrates that any potential risk posed by these residues in much less than the risks encountered in normal everyday life.

  14. Confirmatory factor analysis of the Pittsburgh Sleep Quality Index in rheumatoid arthritis patients.

    PubMed

    Nicassio, Perry M; Ormseth, Sarah R; Custodio, Mara K; Olmstead, Richard; Weisman, Michael H; Irwin, Michael R

    2014-01-01

    The purpose of this research was to evaluate the factor structure of the Pittsburgh Sleep Quality Index (PSQI) in rheumatoid arthritis (RA). The sample included 107 patients with RA, 88 females and seven males, with an average age of 56.09 years, recruited from the greater Southern California area. Confirmatory factor analysis evaluated single, two- and three-factor models. The single factor solution yielded a poor fit to the data. While the three-factor solution had the best fit, the two-factor solution, comprised of sleep efficiency and perceived sleep quality factors, was optimal because it had very good fit, and acceptable reliability for its individual factors. Clinical indices were consistently correlated with the sleep quality factor, but not with the sleep efficiency factor.

  15. 1999 environmental monitoring report for the Bettis Atomic Power Laboratory, Pittsburgh Site

    SciTech Connect

    2000-12-01

    The 1999 results for the Bettis-Pittsburgh radiological and nonradiological environmental monitoring programs are presented. The results demonstrate that the existing procedures ensured that releases to the environment during 1999 were in accordance with applicable Federal, State, County, and local regulations. Evaluation of the environmental data indicates that current operations at the Site continue to have no adverse effect on human health and the quality of the environment. A conservative assessment of radiation exposure to the general public as a result of Site operations demonstrates that the dose received by any member of the public was well below the most restrictive dose limits established by the Environmental Protection Agency, the Nuclear Regulatory Commission, and the US Department of Energy. A risk assessment of potentially exposed populations to chemical residues in the environment at the Site demonstrates that these residues do not pose any significant risk to human health or the environment.

  16. Development of the Nimbus/Pittsburgh axial flow left ventricular assist system.

    PubMed

    Butler, K; Thomas, D; Antaki, J; Borovetz, H; Griffith, B; Kameneva, M; Kormos, R; Litwak, P

    1997-07-01

    Nimbus, Inc. and the University of Pittsburgh's School of Medicine have been collaborators developing rotary blood pump technology since 1992. Currently, a major focus is on an implantable left ventricular assist system (LVAS) that utilizes an electric powered axial flow blood pump. In addition to the blood pump, a major development item is the electronic controller and the control algorithm for modulating the pump speed in response to varying physiologic demands. Methods being used in developing the axial flow LVAS include the use of computational fluid dynamic modeling of the interior flow field of the pump, flow visualization of the flow field using laser based imaging, and computer simulation of blood pump-physiological interactions as well as an extensive in vivo test program. Results to date include successful in vivo tests of blood pumps with nonlubricated bearings and demonstrations of auto speed control using electrical current as the observable parameter.

  17. Structural Validity of the Pittsburgh Sleep Quality Index in Chinese Undergraduate Students

    PubMed Central

    Guo, Suran; Sun, Wenmei; Liu, Chang; Wu, Siwei

    2016-01-01

    The purpose of this study was to examine the structural validity of the Pittsburgh Sleep Quality Index (PSQI) in Chinese undergraduate students. A cross-sectional questionnaire survey with 631 Chinese undergraduate students was conducted, and the questionnaire package included a measure of demographic characteristics, PSQI, Chinese editions of Center for Epidemiologic Studies-Depression, State- Trait Anxiety Inventory, Rumination Response Scale, and Perceived Social Support Scale. Results showed that the item “use of sleep medicine” was not suitable for use with this population, that a two-factor model provided the best fit to the data as assessed through confirmatory factor analysis, and that other indices were consistently correlated with the sleep quality but not the sleep efficiency factor. PMID:27551270

  18. Confirmatory Factor Analysis of the Pittsburgh Sleep Quality Index in Rheumatoid Arthritis Patients

    PubMed Central

    Nicassio, Perry M.; Ormseth, Sarah R.; Custodio, Mara K.; Olmstead, Richard; Weisman, Michael H.; Irwin, Michael R.

    2014-01-01

    The purpose of this research was to evaluate the factor structure of the Pittsburgh Sleep Quality Index (PSQI) in rheumatoid arthritis (RA). The sample included 107 patients with RA, 88 females and seven males, with an average age of 56.09 years, recruited from the greater Southern California area. Confirmatory factor analysis evaluated single, two- and three-factor models. The single factor solution yielded a poor fit to the data. While the three-factor solution had the best fit, the two-factor solution, comprised of sleep efficiency and perceived sleep quality factors, was optimal because it had very good fit, and acceptable reliability for its individual factors. Clinical indices were consistently correlated with the sleep quality factor, but not with the sleep efficiency factor. PMID:23390921

  19. Fostering Student Interest in Neurological Surgery: The University of Pittsburgh Experience.

    PubMed

    Kashkoush, Ahmed; Feroze, Rafey; Myal, Stephanie; Prabhu, Arpan V; Sansosti, Alexandra; Tonetti, Daniel; Agarwal, Nitin

    2017-08-30

    Early involvement and research in neurosurgery can increase chances for medical students to successfully matriculate into residency. This study reports the creation of a Neurological Surgery Interest Group (NSIG) at the University of Pittsburgh School of Medicine and shares its activities over two academic years. In October 2014, the University of Pittsburgh School of Medicine's NSIG was created to augment medical student interest in neurosurgery. The group consisted of four appointed officers for a membership base of 100 students. In June 2015, a neurosurgery resident and faculty member joined as mentors. A research committee of 14 medical students was created to conduct collaborative research projects with the department. In August of 2015 and 2016, surveys were sent out to the research committee regarding research productivity. The NSIG hosted 17 medical student-oriented events over two years including didactic and suturing workshops, senior faculty panels, post-match talks, and a neurosurgery networking dinner. A survey of students about scholarly achievement in neurosurgery reported 17 accepted publications in peer-reviewed journals with a mean impact factor of 3.5 ± 2.5. Ten abstracts were submitted to the 2015 and 2016 American Association of Neurological Surgeons Scientific Meetings with a 100% acceptance rate. An increase in the number of students matching from our institution into neurosurgery residencies was observed following the group's inception. An NSIG can be mutually beneficial to both medical students and an institution's neurosurgical department. This study's findings may be applied to numerous specialties and across various academic institutions. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. Validity and reliability of the Taiwanese version of the Pittsburgh Sleep Quality Index in cancer patients.

    PubMed

    Tzeng, Jann Inn; Fu, Ya-Wen; Lin, Chia-Chin

    2012-01-01

    Sleep disturbance remains a common symptom among cancer patients. Assessment of sleep disturbance in cancer patients is hindered by infrequent use of standardized tools for sleep management. The purposes of this study were to validate the Taiwanese version of the Pittsburgh Sleep Quality Index (PSQI-T) and to determine detection cut-off points in cancer patients. A cross-sectional and descriptive correlational design. A sample of 205 Taiwanese patients with various cancer diagnoses. The survey included the Pittsburgh Sleep Quality Index-Taiwanese version, the MD Anderson Symptom Inventory-Taiwanese version, the Brief Fatigue Inventory-Taiwanese version, the seven-day sleep log, and Manual of Mental Disorders, Fourth Edition. The internal consistency Cronbach's alpha for the PSQI was 0.79. Test-retest reliability was 0.91 for the global score over a 20- to 28-day interval in a sample of 16 patients. Construct validity was established by a significant relationship of the PSQI-T global score to the total symptom severity score and the fatigue severity score. Convergent validity was examined by correlating the PSQI-T scores and scores of the DSM-IV and scores on the seven-day sleep log. Known-group validity was established by comparing PSQI-T scores for patients having low fatigue levels and those having high fatigue levels. Receiver-operating characteristic (ROC) curves were used to determine the detection cut-off points. We found that a PSQI-T global score of 8 generates the best sensitivity and specificity for measuring sleep disturbance in cancer patients. The PSQI-T is a reliable, valid, and sensitive instrument for measuring sleep quality among Taiwanese cancer patients. Copyright © 2011 Elsevier Ltd. All rights reserved.

  1. Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B.

    PubMed

    Price, Julie C; Klunk, William E; Lopresti, Brian J; Lu, Xueling; Hoge, Jessica A; Ziolko, Scott K; Holt, Daniel P; Meltzer, Carolyn C; DeKosky, Steven T; Mathis, Chester A

    2005-11-01

    A valid quantitative imaging method for the measurement of amyloid deposition in humans could improve Alzheimer's disease (AD) diagnosis and antiamyloid therapy assessment. Our group developed Pittsburgh Compound-B (PIB), an amyloid-binding radiotracer, for positron emission tomography (PET). The current study was aimed to further validate PIB PET through quantitative imaging (arterial input) and inclusion of subjects with mild cognitive impairment (MCI). Pittsburgh Compound-B studies were performed in five AD, five MCI, and five control subjects and five subjects were retested within 20 days. Magnetic resonance images were acquired for partial volume correction and region-of-interest definition (e.g., posterior cingulate: PCG; cerebellum: CER). Data were analyzed using compartmental and graphical approaches. Regional distribution volume (DV) values were normalized to the reference region (CER) to yield DV ratios (DVRs). Good agreement was observed between compartmental and Logan DVR values (e.g., PCG: r=0.89, slope=0.91); the Logan results were less variable. Nonspecific PIB retention was similar across subjects (n=15, Logan CER DV: 3.63+/-0.48). Greater retention was observed in AD cortical areas, relative to controls (P<0.05). The PIB retention in MCI subjects appeared either 'AD-like' or 'control-like'. The mean test/retest variation was approximately 6% in primary areas-of-interest. The Logan analysis was the method-of-choice for the PIB PET data as it proved stable, valid, and promising for future larger studies and voxel-based statistical analyses. This study also showed that it is feasible to perform quantitative PIB PET imaging studies that are needed to validate simpler methods for routine use across the AD disease spectrum.

  2. A geostatistical approach to predicting sulfur content in the Pittsburgh coal bed

    USGS Publications Warehouse

    Watson, W.D.; Ruppert, L.F.; Bragg, L.J.; Tewalt, S.J.

    2001-01-01

    The US Geological Survey (USGS) is completing a national assessment of coal resources in the five top coal-producing regions in the US. Point-located data provide measurements on coal thickness and sulfur content. The sample data and their geologic interpretation represent the most regionally complete and up-to-date assessment of what is known about top-producing US coal beds. The sample data are analyzed using a combination of geologic and Geographic Information System (GIS) models to estimate tonnages and qualities of the coal beds. Traditionally, GIS practitioners use contouring to represent geographical patterns of "similar" data values. The tonnage and grade of coal resources are then assessed by using the contour lines as references for interpolation. An assessment taken to this point is only indicative of resource quantity and quality. Data users may benefit from a statistical approach that would allow them to better understand the uncertainty and limitations of the sample data. To develop a quantitative approach, geostatistics were applied to the data on coal sulfur content from samples taken in the Pittsburgh coal bed (located in the eastern US, in the southwestern part of the state of Pennsylvania, and in adjoining areas in the states of Ohio and West Virginia). Geostatistical methods that account for regional and local trends were applied to blocks 2.7 mi (4.3 km) on a side. The data and geostatistics support conclusions concerning the average sulfur content and its degree of reliability at regional- and economic-block scale over the large, contiguous part of the Pittsburgh outcrop, but not to a mine scale. To validate the method, a comparison was made with the sulfur contents in sample data taken from 53 coal mines located in the study area. The comparison showed a high degree of similarity between the sulfur content in the mine samples and the sulfur content represented by the geostatistically derived contours. Published by Elsevier Science B.V.

  3. Psychometric Properties of the Pittsburgh Sleep Quality Index (PSQI) in a Cohort of Peruvian Pregnant Women

    PubMed Central

    Zhong, Qiu-Yue; Gelaye, Bizu; Sánchez, Sixto E.; Williams, Michelle A.

    2015-01-01

    Study Objectives: We sought to evaluate the construct validity and factor structure of the Spanish-language version of the Pittsburgh Sleep Quality Index (PSQI) among pregnant Peruvian women. Methods: A cohort of 642 women were interviewed at ≤ 16 weeks of gestation. During interview, we ascertained information about lifestyles, demographics, sleep characteristics, and mood symptoms. Stress induced sleep disturbance, depressive symptoms, and anxiety symptoms were evaluated using the Ford Insomnia Response to Stress Test (FIRST), Patient Health Questionnaire-9 (PHQ-9), and Generalized Anxiety Disorder-7 (GAD-7) assessment scales, respectively. Consistency indices, exploratory and confirmatory factor analyses, correlations, and logistic regressions were used. Results: Both exploratory and confirmatory factor analyses indicated a three-factor solution: sleep quality, sleep efficiency, and sleep medication. We observed significantly positive correlations of the PSQI with the FIRST (0.42), the PHQ-9 (0.49), and the GAD-7 (0.46). Poor sleepers (PSQI global score > 5) had significantly increased odds of experiencing stress-induced sleep disturbance (odds ratio, OR = 3.57; 95% CI: 2.40, 5.31), depression (OR = 5.48; 95% CI: 3.58, 8.37), and generalized anxiety disorder (OR = 4.57; 95% CI: 3.08, 6.76). Conclusions: The Spanish-language version of the PSQI instrument was found to have good construct validity among pregnant Peruvian women. Consistent with some other studies, the PSQI was found to have a three-factor structure. Further assessment and validation studies are needed to determine whether the three, factor-specific scoring of the PSQI is favored over the PSQI global score in diverse populations. Citation: Zhong QY, Gelaye B, Sánchez SE, Williams MA. Psychometric properties of the Pittsburgh Sleep Quality Index (PSQI) in a cohort of Peruvian pregnant women. J Clin Sleep Med 2015;11(8):869–877. PMID:25845902

  4. Creating an infrastructure for training in the responsible conduct of research: the University of Pittsburgh's experience.

    PubMed

    Barnes, Barbara E; Friedman, Charles P; Rosenberg, Jerome L; Russell, Joanne; Beedle, Ari; Levine, Arthur S

    2006-02-01

    In response to public concerns about the consequences of research misconduct, academic institutions have become increasingly cognizant of the need to implement comprehensive, effective training in the responsible conduct of research (RCR) for faculty, staff, students, and external collaborators. The ability to meet this imperative is challenging as universities confront declining financial resources and increasing complexity of the research enterprise. The authors describe the University of Pittsburgh's design, implementation, and evaluation of a Web-based, institution-wide RCR training program called Research and Practice Fundamentals (RPF). This project, established in 2000, was embedded in the philosophy, organizational structure, and technology developed through the Integrated Advanced Information Management Systems grant from the National Library of Medicine. Utilizing a centralized, comprehensive approach, the RPF system provides an efficient mechanism for deploying content to a large, diverse cohort of learners and supports the needs of research administrators by providing access to information about who has successfully completed the training. During its first 3 years of operation, the RPF served over 17,000 users and issued more than 38,000 training certificates. The 18 modules that are currently available address issues required by regulatory mandates and other content areas important to the research community. RPF users report high levels of satisfaction with content and ease of using the system. Future efforts must explore methods to integrate non-RCR education and training into a centralized, cohesive structure. The University of Pittsburgh's experience with the RPF demonstrates the importance of developing an infrastructure for training that is comprehensive, scalable, reliable, centralized, affordable, and sustainable.

  5. Partners in Pittsburgh Public Schools' Excellence for All Initiative: Findings from the First Year of Implementation. Documented Briefing. DB-544-FFE

    ERIC Educational Resources Information Center

    Tharp-Taylor, Shannah; Nelson, Catherine Awsumb; Dembosky, Jacob W.; Gill, Brian

    2007-01-01

    The Pittsburgh Public School District asked the RAND Corporation to monitor the first year's implementation (2006-2007) of Excellence for All (EFA) and provide feedback to district staff, the board, and other stakeholders. The Pittsburgh Public School District leadership developed EFA with the aim of increasing student achievement by improving…

  6. Using a Merit-Based Scholarship Program to Increase Rates of College Enrollment in an Urban School District: The Case of the Pittsburgh Promise

    ERIC Educational Resources Information Center

    Bozick, Robert; Gonzalez, Gabriella; Engberg, John

    2015-01-01

    The Pittsburgh Promise is a scholarship program that provides $5,000 per year toward college tuition for public high school graduates in Pittsburgh, Pennsylvania who earned a 2.5 GPA and a 90% attendance record. This study used a difference-in-difference design to assess whether the introduction of the Promise scholarship program directly…

  7. Using a Merit-Based Scholarship Program to Increase Rates of College Enrollment in an Urban School District: The Case of the Pittsburgh Promise

    ERIC Educational Resources Information Center

    Bozick, Robert; Gonzalez, Gabriella; Engberg, John

    2015-01-01

    The Pittsburgh Promise is a scholarship program that provides $5,000 per year toward college tuition for public high school graduates in Pittsburgh, Pennsylvania who earned a 2.5 GPA and a 90% attendance record. This study used a difference-in-difference design to assess whether the introduction of the Promise scholarship program directly…

  8. Academic Advising in The College of Arts and Sciences at The University of Pittsburgh. A Descriptive Report.

    ERIC Educational Resources Information Center

    Koloc, Fred; And Others

    Undergraduate academic advising at University of Pittsburgh's College of Arts and Sciences (CAS) occurs at two levels: freshmen-sophomore and junior-senior. The advising center assigns freshmen and sophomores advisors who are graduate students. In addition to discussing courses and plans, students fill out registration forms each term with their…

  9. A Delphi Assessment Study for the Pittsburgh Regional Library Center. Programs and Services to Be Implemented in PRLC by 1982.

    ERIC Educational Resources Information Center

    Penland, Patrick R.; And Others

    Two rounds of questionnaires were distributed to the 176 members of the Pittsburgh Regional Library Center in order to achieve a consensus on the refinement and prioritization of possible library services and programs by members of the center. Respondents were asked to assign a single importance score to each of the services listed; the first…

  10. Report on the Study of Library Use at Pitt by Professor Allen Kent, et al. (A Pittsburgh Reply).

    ERIC Educational Resources Information Center

    MacLeod, Murdo J.; Barkowski, Casimir

    This report from the Senate Library Committee at the University of Pittsburgh evaluates a widely publicized study of monograph and periodical use conducted at Pitt by Professor Allen Kent and his associates from 1975-1977. Areas of the study which are examined include structure in text and footnotes, and experimental design, execution, and…

  11. Creating Social Connections in Higher Education: Insights from the Campus Canines Program at the University of Pittsburgh

    ERIC Educational Resources Information Center

    Camaioni, Nicole

    2013-01-01

    The overall purpose of this study was to capture the relationships made during the Campus Canines Program, an animal-assisted activity program, at the University of Pittsburgh. Meaningful social relationships create greater educational satisfaction. These social relationships are an important piece to creating and sustaining student involvement,…

  12. Creating Social Connections in Higher Education: Insights from the Campus Canines Program at the University of Pittsburgh

    ERIC Educational Resources Information Center

    Camaioni, Nicole

    2013-01-01

    The overall purpose of this study was to capture the relationships made during the Campus Canines Program, an animal-assisted activity program, at the University of Pittsburgh. Meaningful social relationships create greater educational satisfaction. These social relationships are an important piece to creating and sustaining student involvement,…

  13. The Investigation of Demand for a Rapid Document Delivery Service for the University of Pittsburgh Library System. Final Report.

    ERIC Educational Resources Information Center

    Montgomery, K. Leon; And Others

    A joint project of the University of Pittsburgh Library System and the School of Library and Information Science investigated the need for a rapid document delivery service within the University Library System (ULS). Two instruments were designed to answer questions about library patrons' uses of bibliographic citations retrieved in online…

  14. 78 FR 69878 - AT&T Corporation, a Subsidiary of AT&T Inc., Business Billing Customer Care, Pittsburgh...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-21

    ... Employment and Training Administration AT&T Corporation, a Subsidiary of AT&T Inc., Business Billing Customer... apply for Trade Adjustment Assistance (TAA) applicable to workers and former workers of AT&T Corporation, a subsidiary of AT&T Inc., Business Billing Customer Care, Pittsburgh, Pennsylvania (subject firm...

  15. Findings From the Pittsburgh Youth Study: Cognitive Impulsivity and Intelligence as Predictors of the Age-Crime Curve

    ERIC Educational Resources Information Center

    Loeber, Rolf; Menting, Barbara; Lynam, Donald R.; Moffitt, Terri E.; Stouthamer-Loeber, Magda; Stallings, Rebecca; Farrington, David P.; Pardini, Dustin

    2012-01-01

    Objective: This article first summarizes key research findings from the Pittsburgh Youth Study from 1987 to the present, and focuses on delinquency in 1,517 young men who have been followed up from late childhood into their 20s. Second, the article addresses how indicators of self-control prospectively predict later offending, and whether the…

  16. Child Developmental Impact of Pittsburgh's Early Childhood Initiative (ECI) in High-Risk Communities: First-Phase Authentic Evaluation Research.

    ERIC Educational Resources Information Center

    Bagnato, Stephen J.; Suen, Hoi K.; Brickley, Dale; Smith-Jones, Janell; Dettore, Ernie

    2002-01-01

    This study used an "enhanced constructed comparison group" statistical model to conduct longitudinal research on the child developmental impact of Pittsburgh's early childhood initiative (ECI), a partnership to provide high-quality early care and education for children in high-risk neighborhoods. First-phase findings indicate that…

  17. Meeting the Challenges of Multicultural Education: A Report from the Evaluation of Pittsburgh's Prospect Multicultural Education Center.

    ERIC Educational Resources Information Center

    Gottfredson, Gary D.; And Others

    This report presents an evaluation of the Multicultural Education Demonstration Program in Pittsburgh (Pennsylvania), an effort to address racial and ethnic diversity in a middle school. The report covers the implementation of the program since its inception in May 1989 through the beginning of the 1991-92 school year. It describes the program's…

  18. Meeting the Challenges of Multicultural Education. The Second Report from the Evaluation of Pittsburgh's Prospect Multicultural Education Center.

    ERIC Educational Resources Information Center

    McHugh, Barbara; And Others

    This report describes a study from May 1989 through 1991-92 of the implementation and status of the Multicultural Education Program being developed in the Pittsburgh (Pennsylvania) public schools. It also includes the perspectives of participating students, staff, and parents. The multicultural education demonstration in the Prospect Center…

  19. Symposium on Emerging Areas in Applied Mathematics Held in Pittsburgh, Pennsylvania on 24-26 June 1985.

    DTIC Science & Technology

    1985-12-17

    General Motors Research Laboratories, Michigan; Numerical Solution of Partial Differential Equations II, James Boland, University of Pittsburgh, and...University, and Alexander P. Morgan, General Motors Research Laboratories, Michigan; Optimization of Large Engineering Systems, Vadim Komkov...Inc. , David Sartori; Pratt & Whitney Aircraft, Leon Seitelman; General Motors Research Laboratories, James Cavendish; Bettis Atomic Power Laboratories

  20. 75 FR 6635 - Foreign-Trade Zone 33-Pittsburgh, Pennsylvania, Expansion of Manufacturing Authority, Subzone 33E...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-10

    ... Foreign-Trade Zones Board Foreign-Trade Zone 33--Pittsburgh, Pennsylvania, Expansion of Manufacturing..., Pennsylvania An application has been submitted to the Foreign-Trade Zones Board (the Board) by the Regional... the Foreign-Trade Zones Act, as amended (19 U.S.C. 81a-81u), and the regulations of the Board (15...

  1. Findings From the Pittsburgh Youth Study: Cognitive Impulsivity and Intelligence as Predictors of the Age-Crime Curve

    ERIC Educational Resources Information Center

    Loeber, Rolf; Menting, Barbara; Lynam, Donald R.; Moffitt, Terri E.; Stouthamer-Loeber, Magda; Stallings, Rebecca; Farrington, David P.; Pardini, Dustin

    2012-01-01

    Objective: This article first summarizes key research findings from the Pittsburgh Youth Study from 1987 to the present, and focuses on delinquency in 1,517 young men who have been followed up from late childhood into their 20s. Second, the article addresses how indicators of self-control prospectively predict later offending, and whether the…

  2. Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study.

    PubMed

    Leuzy, Antoine; Chiotis, Konstantinos; Hasselbalch, Steen G; Rinne, Juha O; de Mendonça, Alexandre; Otto, Markus; Lleó, Alberto; Castelo-Branco, Miguel; Santana, Isabel; Johansson, Jarkko; Anderl-Straub, Sarah; von Arnim, Christine A F; Beer, Ambros; Blesa, Rafael; Fortea, Juan; Herukka, Sanna-Kaisa; Portelius, Erik; Pannee, Josef; Zetterberg, Henrik; Blennow, Kaj; Nordberg, Agneta

    2016-09-01

    The aim of this study was to assess the agreement between data on cerebral amyloidosis, derived using Pittsburgh compound B positron emission tomography and (i) multi-laboratory INNOTEST enzyme linked immunosorbent assay derived cerebrospinal fluid concentrations of amyloid-β42; (ii) centrally measured cerebrospinal fluid amyloid-β42 using a Meso Scale Discovery enzyme linked immunosorbent assay; and (iii) cerebrospinal fluid amyloid-β42 centrally measured using an antibody-independent mass spectrometry-based reference method. Moreover, we examined the hypothesis that discordance between amyloid biomarker measurements may be due to interindividual differences in total amyloid-β production, by using the ratio of amyloid-β42 to amyloid-β40 Our study population consisted of 243 subjects from seven centres belonging to the Biomarkers for Alzheimer's and Parkinson's Disease Initiative, and included subjects with normal cognition and patients with mild cognitive impairment, Alzheimer's disease dementia, frontotemporal dementia, and vascular dementia. All had Pittsburgh compound B positron emission tomography data, cerebrospinal fluid INNOTEST amyloid-β42 values, and cerebrospinal fluid samples available for reanalysis. Cerebrospinal fluid samples were reanalysed (amyloid-β42 and amyloid-β40) using Meso Scale Discovery electrochemiluminescence enzyme linked immunosorbent assay technology, and a novel, antibody-independent, mass spectrometry reference method. Pittsburgh compound B standardized uptake value ratio results were scaled using the Centiloid method. Concordance between Meso Scale Discovery/mass spectrometry reference measurement procedure findings and Pittsburgh compound B was high in subjects with mild cognitive impairment and Alzheimer's disease, while more variable results were observed for cognitively normal and non-Alzheimer's disease groups. Agreement between Pittsburgh compound B classification and Meso Scale Discovery/mass spectrometry reference

  3. Non-random geographic distribution of patients with cutaneous T-cell lymphoma in the Greater Pittsburgh Area.

    PubMed

    Moreau, Jacqueline F; Buchanich, Jeanine M; Geskin, Jacob Z; Akilov, Oleg E; Geskin, Larisa J

    2014-07-15

    Environmental hazards may play a role in the etiology of cutaneous T-cell lymphoma (CTCL). Some studies have found an increased incidence of CTCL among workers in chemical science, transportation, and manufacturing industries, but other studies have not. This discrepancy may be attributable to population migration, complicating accurate assessment of lifetime exposures. The Pittsburgh population has very low migration rates and most CTCL patients seen at the University of Pittsburgh Medical Center (UPMC) Cutaneous Lymphoma Center are life-long local residents. The Greater Pittsburgh Area used to be an industrial hub. There are residential communities positioned within close proximity to inactive industrial sites that continue to contain pollutants. To determine whether CTCL patients' residences cluster within specific Pittsburgh regions, in particular, those with high levels of environmental pollutants. Our study included patients diagnosed with CTCL at the UPMC Cutaneous Lymphoma Center between 2000 and 2012. We mapped the longitudinal and latitudinal coordinates of patients' residences at diagnosis, superfund sites, toxic release inventory sites, particular matter levels, and dermatologists' offices using ArcMap 10.1. We then performed a SaTScan analysis using zip codes to assess for geographic clustering of patients' residences in the Pittsburgh metropolitan statistical area. We assessed for a correlation between case distribution and both environmental hazards sites and dermatologist density in the area. We identified 274 patients with CTCL in the Greater Pittsburgh area. We identified a statistically significant geographic cluster (p<.001) in zip code 15213, which is the most densely populated neighborhood in Pittsburgh and the site of the region's only CTCL clinic. We observed no relationship between the locations of superfund sites, toxic release inventory sites, or particular matter levels and CTCL case distribution. Our findings do not support an

  4. Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study

    PubMed Central

    Leuzy, Antoine; Chiotis, Konstantinos; Hasselbalch, Steen G.; Rinne, Juha O.; de Mendonça, Alexandre; Otto, Markus; Lleó, Alberto; Castelo-Branco, Miguel; Santana, Isabel; Johansson, Jarkko; Anderl-Straub, Sarah; von Arnim, Christine A. F.; Beer, Ambros; Blesa, Rafael; Fortea, Juan; Herukka, Sanna-Kaisa; Portelius, Erik; Pannee, Josef; Zetterberg, Henrik; Blennow, Kaj

    2016-01-01

    The aim of this study was to assess the agreement between data on cerebral amyloidosis, derived using Pittsburgh compound B positron emission tomography and (i) multi-laboratory INNOTEST enzyme linked immunosorbent assay derived cerebrospinal fluid concentrations of amyloid-β42; (ii) centrally measured cerebrospinal fluid amyloid-β42 using a Meso Scale Discovery enzyme linked immunosorbent assay; and (iii) cerebrospinal fluid amyloid-β42 centrally measured using an antibody-independent mass spectrometry-based reference method. Moreover, we examined the hypothesis that discordance between amyloid biomarker measurements may be due to interindividual differences in total amyloid-β production, by using the ratio of amyloid-β42 to amyloid-β40. Our study population consisted of 243 subjects from seven centres belonging to the Biomarkers for Alzheimer’s and Parkinson’s Disease Initiative, and included subjects with normal cognition and patients with mild cognitive impairment, Alzheimer’s disease dementia, frontotemporal dementia, and vascular dementia. All had Pittsburgh compound B positron emission tomography data, cerebrospinal fluid INNOTEST amyloid-β42 values, and cerebrospinal fluid samples available for reanalysis. Cerebrospinal fluid samples were reanalysed (amyloid-β42 and amyloid-β40) using Meso Scale Discovery electrochemiluminescence enzyme linked immunosorbent assay technology, and a novel, antibody-independent, mass spectrometry reference method. Pittsburgh compound B standardized uptake value ratio results were scaled using the Centiloid method. Concordance between Meso Scale Discovery/mass spectrometry reference measurement procedure findings and Pittsburgh compound B was high in subjects with mild cognitive impairment and Alzheimer’s disease, while more variable results were observed for cognitively normal and non-Alzheimer’s disease groups. Agreement between Pittsburgh compound B classification and Meso Scale Discovery/mass spectrometry

  5. 78 FR 45282 - Pennsylvania Disaster #PA-00058

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-26

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00058 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... determined to be adversely affected by the disaster: Primary Counties: Clearfield; Fayette;...

  6. 32 CFR 701.123 - PA fees.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... duplication for free. (1) DON activities shall waive fees automatically if the direct cost for reproduction of... made on a case-to-case basis. (c) PA fee deposits. Checks or money orders shall be made payable to...

  7. 78 FR 47814 - Pennsylvania Disaster # PA-00059

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-06

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00059 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY.... Small Business Administration, Processing And Disbursement Center, 14925 Kingsport Road, Fort Worth, TX...

  8. A simple model for predicting lung cancer occurrence in a lung cancer screening program: The Pittsburgh Predictor.

    PubMed

    Wilson, David O; Weissfeld, Joel

    2015-07-01

    A user-friendly method for assessing lung cancer risk may help standardize selection of current and former smokers for screening. We evaluated a simple 4-factor model, the Pittsburgh Predictor, against two well-known, but more complicated models for predicting lung cancer risk. Trained against outcomes observed in the National Lung Screening Trial (NLST), the Pittsburgh Predictor used four risk factors, duration of smoking, smoking status, smoking intensity, and age, to predict 6-year lung cancer incidence. After calibrating the Bach and PLCOM2012 models to outcomes observed in the low-dose computed tomography arm of the NLST, we compared model calibration, discrimination, and clinical usefulness (net benefit) in the NLST and Pittsburgh Lung Screening Study (PLuSS) populations. The Pittsburgh Predictor, Bach, and PLCOM2012 represented risk equally well, except for the tendency of PLCOM2012 to overestimate risk in subjects at highest risk. Relative to the Pittsburgh Predictor, Bach and PLCOM2012 increased the area under the receiver operator characteristic curve by 0.007-0.009 and 0.012-0.021 units, respectively, depending on study population. Across a clinically relevant span of 6-year lung cancer risk thresholds (0.01-0.05), Bach and PLCOM2012 increased net benefit by less than 0.1% in NLST and 0.3% in PLuSS. In exchange for a small reduction in prediction accuracy, a simpler lung cancer risk prediction model may facilitate standardized procedures for advising and selecting patients with respect to lung cancer screening. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  9. Oxidation of gas-phase protactinium ions, Pa+ and Pa2+: formation and properties of PaO2(2+)(g), protactinyl.

    PubMed

    Santos, Marta; de Matos, António Pires; Marçalo, Joaquim; Gibson, John K; Haire, Richard G; Tyagi, Rajni; Pitzer, Russell M

    2006-05-04

    Oxidation reactions of bare and ligated, monopositive, and dipositive Pa ions in the gas phase were studied by Fourier transform ion cyclotron resonance mass spectrometry. Seven oxidants were employed, ranging from the thermodynamically robust N(2)O to the relatively weak CH(2)O-all oxidized Pa(+) to PaO(+) and PaO(+) to PaO(2)(+). On the basis of experimental observations, it was established that D[Pa(+)-O] and D[OPa(+)-O] > or = 751 kJ mol(-1). Estimates for D[Pa(+)-O], D[OPa(+)-O], IE[PaO], and IE[PaO(2)] were also obtained. The seven oxidants reacted with Pa(2+) to produce PaO(2+), indicating that D[Pa(2+)-O] > or = 751 kJ mol(-1). A particularly notable finding was the oxidation of PaO(2+) by N(2)O to PaO(2)(2+), a species, which formally comprises Pa(VI). Collision-induced dissociation of PaO(2)(2+) suggested the protactinyl connectivity, {O-Pa-O}(2+). The experimentally determined IE[PaO(2)(+)] approximately 16.6 eV is in agreement with self-consistent-field and configuration interaction calculations for PaO(2)(+) and PaO(2)(2+). These calculations provide insights into the electronic structures of these ions and indicate the participation of 5f orbitals in bonding and a partial "6p hole" in the case of protactinyl. It was found that PaO(2)(2+) catalyzes the oxidation of CO by N(2)O-such O atom transport via a dipositive metal oxide ion is distinctive. It was also observed that PaO(2)(2+) is capable of activating H(2) to form the stable PaO(2)H(2+) ion.

  10. Functional Characterization of Phalaenopsis aphrodite Flowering Genes PaFT1 and PaFD

    PubMed Central

    Jang, Seonghoe; Choi, Sang-Chul; Li, Hsing-Yi; An, Gynheung; Schmelzer, Elmon

    2015-01-01

    We show that the key flowering regulators encoded by Phalaenopsis aphrodite FLOWERING LOCUS T1 (PaFT1) and PaFD share high sequence homologies to these from long-day flowering Arabidopsis and short-day flowering rice. Interestingly, PaFT1 is specifically up-regulated during flowering inductive cooling treatment but is not subjected to control by photoperiod in P. aphrodite. Phloem or shoot apex-specific expression of PaFT1 restores the late flowering of Arabidopsis ft mutants. Moreover, PaFT1 can suppress the delayed flowering caused by SHORT VEGATATIVE PHASE (SVP) overexpression as well as an active FRIGIDA (FRI) allele, indicating the functional conservation of flowering regulatory circuit in different plant species. PaFT1 promoter:GUS in Arabidopsis showed similar staining pattern to that of Arabidopsis FT in the leaves and guard cells but different in the shoot apex. A genomic clone or heat shock-inducible expression of PaFT1 is sufficient to the partial complementation of the ft mutants. Remarkably, ectopic PaFT1 expression also triggers precocious heading in rice. To further demonstrate the functional conservation of the flowering regulators, we show that PaFD, a bZIP transcription factor involved in flowering promotion, interacts with PaFT1, and PaFD partially complemented Arabidopsis fd mutants. Transgenic rice expressing PaFD also flowered early with increased expression of rice homologues of APETALA1 (AP1). Consistently, PaFT1 knock-down Phalaenopsis plants generated by virus-induced gene silencing exhibit delayed spiking. These studies suggest functional conservation of FT and FD genes, which may have evolved and integrated into distinct regulatory circuits in monopodial orchids, Arabidopsis and rice that promote flowering under their own inductive conditions. PMID:26317412

  11. Functional Characterization of Phalaenopsis aphrodite Flowering Genes PaFT1 and PaFD.

    PubMed

    Jang, Seonghoe; Choi, Sang-Chul; Li, Hsing-Yi; An, Gynheung; Schmelzer, Elmon

    2015-01-01

    We show that the key flowering regulators encoded by Phalaenopsis aphrodite FLOWERING LOCUS T1 (PaFT1) and PaFD share high sequence homologies to these from long-day flowering Arabidopsis and short-day flowering rice. Interestingly, PaFT1 is specifically up-regulated during flowering inductive cooling treatment but is not subjected to control by photoperiod in P. aphrodite. Phloem or shoot apex-specific expression of PaFT1 restores the late flowering of Arabidopsis ft mutants. Moreover, PaFT1 can suppress the delayed flowering caused by SHORT VEGATATIVE PHASE (SVP) overexpression as well as an active FRIGIDA (FRI) allele, indicating the functional conservation of flowering regulatory circuit in different plant species. PaFT1 promoter:GUS in Arabidopsis showed similar staining pattern to that of Arabidopsis FT in the leaves and guard cells but different in the shoot apex. A genomic clone or heat shock-inducible expression of PaFT1 is sufficient to the partial complementation of the ft mutants. Remarkably, ectopic PaFT1 expression also triggers precocious heading in rice. To further demonstrate the functional conservation of the flowering regulators, we show that PaFD, a bZIP transcription factor involved in flowering promotion, interacts with PaFT1, and PaFD partially complemented Arabidopsis fd mutants. Transgenic rice expressing PaFD also flowered early with increased expression of rice homologues of APETALA1 (AP1). Consistently, PaFT1 knock-down Phalaenopsis plants generated by virus-induced gene silencing exhibit delayed spiking. These studies suggest functional conservation of FT and FD genes, which may have evolved and integrated into distinct regulatory circuits in monopodial orchids, Arabidopsis and rice that promote flowering under their own inductive conditions.

  12. 231Pa and 233Pa Neutron-Induced Fission Data Analysis

    SciTech Connect

    Maslov, V.M.; Tetereva, N.A.; Baba, M.; Hasegawa, A.; Kornilov, N.V.; Kagalenko, A.B.

    2005-05-24

    The 231Pa and 233Pa neutron-induced fission cross-section database is analyzed within the Hauser-Feshbach approach. The consistency of neutron-induced fission cross-section data and data extracted from transfer reactions is investigated. The fission probabilities of Pa, fissioning in 231,233Pa(n,nf) reactions, are defined by fitting (3He,d) or (3He,t) transfer-reaction data. The present estimate of the 233Pa(n,f) fission cross section above the emissive fission threshold is supported by smooth level-density parameter systematics, validated in the case of the 231Pa(n,f) data description up to En =20 MeV.

  13. Fecal-indicator bacteria in the Allegheny, Monongahela, and Ohio Rivers, near Pittsburgh, Pennsylvania, July-September 2001

    USGS Publications Warehouse

    Fulton, John W.; Buckwalter, Theodore F.

    2004-01-01

    This report presents the results of a study by the Allegheny County Health Department (ACHD) and the U.S. Geological Survey (USGS) to determine the concentrations of fecal-indicator bacteria in the Allegheny, Monongahela, and Ohio Rivers (Three Rivers) in Allegheny County, Pittsburgh, Pa. Water-quality samples and river-discharge measurements were collected from July to September 2001 during dry- (72-hour dry antecedent period), mixed-, and wet-weather (48-hour dry antecedent period and at least 0.3 inch of rain in a 6-hour period) conditions at five sampling sites on the Three Rivers in Allegheny County. Water samples were collected weekly to establish baseline conditions and during successive days after three wet-weather events. Water samples were analyzed for fecal-indicator organisms including fecal-coliform (FC) bacteria, Escherichia coli (E. coli), and enterococci bacteria. Water samples were collected by the USGS and analyzed by the ACHD Laboratory. At each site, left-bank and right-bank surface-water samples were collected in addition to a composite sample (discharge-weighted sample representative of the channel cross section as a whole) at each site. Fecal-indicator bacteria reported in bank and composite samples were used to evaluate the distribution and mixing of bacteria-source streams in receiving waters such as the Three Rivers. Single-event concentrations of enterococci, E. coli, and FC during dry-weather events were greater than State and Federal water-quality standards (WQS) in 11, 28, and 28 percent of the samples, respectively; during mixed-weather events, concentrations of fecal-indicator bacteria were greater than WQS in 28, 37, and 43 percent of the samples, respectively; and during wet-weather events, concentrations of fecal-indicator bacteria were greater than WQS in 56, 71, and 81 percent of samples, respectively. Single-event, wet-weather concentrations exceeded those during dry-weather events for all sites except the Allegheny River at

  14. 1996 environmental monitoring report for the Bettis Atomic Power Laboratory, Pittsburgh Site

    SciTech Connect

    1996-12-31

    The 1996 results for the Bettis-Pittsburgh radiological and non-radiological environmental monitoring programs are presented. The primary mission of the Bettis Laboratory has been directed toward the design, development, testing, and operation of nuclear reactor propulsion plants for naval surface and submarine vessels. The results obtained from the monitoring programs demonstrate that the existing procedures ensured that releases to the environment during 1996 were in accordance with applicable federal, state, county, and local regulations. Evaluation of the environmental data indicated that the current operations at the Site continue to have no adverse effect on the quality of the environment. A conservative assessment of radiation exposure to the general public as a result of Site operations demonstrated that the dose received by any member of the public was well below the most restrictive dose limits established by the Environmental Protection Agency, the Nuclear Regulatory Commission and the US Department of Energy. A risk assessment of potentially exposed populations to chemical residues in the environment at the Site demonstrated that these residues do not pose any significant health risk.

  15. Adaptation of a 3-factor model for the Pittsburgh Sleep Quality Index in Portuguese older adults.

    PubMed

    Becker, Nathália Brandolim; de Neves Jesus, Saul

    2017-05-01

    The present study examined the factor structure of the Pittsburgh Sleep Quality Index (PSQI) in a sample of older Portuguese adults using a cross-validation approach. Design is a cross-sectional. A convenience sample of 204 community-dwelling older adults (M=70.05, SD=7.15) were included. The global sleep quality (GSQ) score ranged from 0 to 18 with a mean of 5.98 (SD±3.45). The distribution showed that gender and perception of oneself as healthy influences GSQ in this sample. Cronbach's α was 0.69, but increased to 0.70 if the "use of sleep medication" component was deleted. Exploratory factor analysis (EFA) demonstrated two factor model is better than one factor, and a model fit with good indices (chi-square=8.649, df=8, p=0.373). Confirmatory factor analysis (CFA) was performed on the single factor, two factor, and three factor models, with and without the "use of sleep medications" component. The best model was the 3-factor model without the "use of sleep medications" component (chi-square=1.214, df=6, GFI=0.997, AGFI=0.918, CFI=0.986, RMSEA=0.046). The adaptation of the model is similar to the original model, with the only change being the exclusion of the "use of medications to sleep" component. We suggest using that component as a complementary qualitative assessment of health. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

  16. Factor structure of the Chinese version of the Pittsburgh sleep quality index in breast cancer patients.

    PubMed

    Ho, Rainbow T H; Fong, Ted C T

    2014-05-01

    The Pittsburgh Sleep Quality Index (PSQI) is used extensively to assess subjective sleep disturbance in cancer populations. Although previous studies on the PSQI suggested a better fit for a two- or three-factor model than the original one-factor model, none accounted for the indicator-specific effect between sleep duration and habitual sleep efficiency. This study evaluated the PSQI's dimensionality and its convergent validity with cancer-related psychopathological states in female breast cancer patients. The PSQI was administered to 197 women with breast cancer. Confirmatory factor analysis examined the relative fit of one-, two-, three-, and revised one-factor models. The PSQI's convergent validity was evaluated via bivariate correlations between the PSQI factor scores and measures of anxiety, depression, fatigue, pain, and quality of life. Confirmatory factor analyses showed an adequate fit for the revised one-factor model with the PSQI global score as the overall index of sleep disturbance. Although the revised one- and two-factor solutions showed statistically equivalent model fits, the one-factor model was selected due to utility reasons. The severity of sleep dysfunction that the PSQI global score represented was positively correlated with anxiety, depression, fatigue, pain, and reduced quality of life. The results support the PSQI's original unidimensional structure, demonstrating that the PSQI global score is a valid and parsimonious measure for assessing and screening sleep dysfunction in cancer patients. Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

  17. Reconstruction of the 1994 Pittsburgh Airplane Accident Using a Computer Simulation

    NASA Technical Reports Server (NTRS)

    Parks, Edwin K.; Bach, Ralph E., Jr.; Shin, Jae Ho

    1998-01-01

    On September 8, 1994, a Boeing 737-300 passenger airplane was on a downwind approach to the Pittsburgh International Airport at an altitude of 5000 feet above ground level (6000 feet MSL). While in a shallow left turn onto a downwind approach heading, the airplane crossed into the vortex trail of a Boeing 727 flying in the same approach pattern about 4 miles ahead. The B-737 airplane rolled and turned sharply to the left, exited the vortex wake and plunged into the ground. Weather was not a factor in the accident. The airplane was equipped with a 11+ channel digital Flight Data Recorder (FDR) and a multiple channel Cockpit Voice Recorder (CVR). Both recorders were recovered from the crash site and provided excellent data for the development of an accident scenario. Radar tracking of the two airplanes as well as the indicated air speed (IAS) perturbations clearly visible on the B-737 FDR recordings indicate that the upset was apparently initiated by the airplane's crossing into the wake of the B-727 flying ahead in the same traffic pattern. A 6 degree-of-freedom simulation program for the B-737 airplane using MATLAB and SIMULINK was constructed. The simulation was initialized at the stabilized flight conditions of the airplane about 13 seconds prior to its entry into the vortex trail of the B-727 airplane. By assuming a certain combination of control inputs, it was possible to produce a simulated motion that closely matched that recorded on the FDR.

  18. Evaluation of sleep disorders in cancer patients based on Pittsburgh Sleep Quality Index.

    PubMed

    Akman, Tulay; Yavuzsen, Tugba; Sevgen, Zeynep; Ellidokuz, Hulya; Yilmaz, Ahmet Ugur

    2015-07-01

    Insomnia, poor sleep quality and short sleep durations are the most common problems seen in cancer patients. More studies are needed about sleep disorders in cancer patients. In our study, we aimed to investigate the prevalence of sleep disorders and the impact of these problems on the quality of life in cancer patients. Pittsburgh Sleep Quality Index (PSQI) was given to a total of 314 patients. The psychometric evaluation of the Turkish version of PSQI in cancer patients revealed that 127 (40.4%) patients had global PSQI scores >5, indicating poor sleep quality. There was no statistically significant relationship between PSQI scores and sexuality, marital status, cancer stage and chemotherapy type (P > 0.05); while the patients with bone and visceral metastasis had much lower PSQI scores (P = 0.006). Patients with Eastern Cooperative Oncology Group performance scores of 3 or more had also significantly lower PSQI scores (P = 0.02). In conclusion, PSQI questionnaire may be used to evaluate the sleep disorders in cancer patients. Consistent use of multi-item measures such as PSQI with established reliability and validity would improve our understanding of difficulties experienced by cancer patients with chronic insomnia. © 2015 John Wiley & Sons Ltd.

  19. Progress on development of the Nimbus-University of Pittsburgh axial flow left ventricular assist system.

    PubMed

    Thomas, D C; Butler, K C; Taylor, L P; Le Blanc, P; Rintoul, T C; Petersen, T V; Griffith, B P; Kormos, R L; Borovetz, H S; Litwak, P; Kameneva, M V; Choi, S; Burgreen, G W; Wu, Z; Antaki, J F

    1998-01-01

    Nimbus Inc. (Rancho Cordova, CA) and the University of Pittsburgh have completed the second year of development of a totally implanted axial flow blood pump under the National Institutes of Health Innovative Ventricular Assist System Program. The focus this year has been on completing pump hydraulic development and addressing the development of the other key system components. Having demonstrated satisfactory pump hydraulic and biocompatibility performance, pump development has focused on design features that improve pump manufacturability. A controller featuring full redundancy has been designed and is in the breadboard test phase. Initial printed circuit layout of this circuit has shown it to be appropriately sized at 5 x 6 cm to be compatible with implantation. A completely implantable system requires the use of a transcutaneous energy transformer system (TETS) and a diagnostic telemetry system. The TETS power circuitry has been redesigned incorporating an improved, more reliable operating topography. A telemetry circuit is undergoing characterization testing. Closed loop speed control algorithms are being tested in vitro and in vivo with good success. Eleven in vivo tests were conducted with durations from 1 to 195 days. Endurance pumps have passed the 6 month interval with minimal bearing wear. All aspects of the program continue to function under formal quality assurance.

  20. Continued development of the Nimbus/University of Pittsburgh (UOP) axial flow left ventricular assist system.

    PubMed

    Thomas, D C; Butler, K C; Taylor, L P; Le Blanc, P; Griffith, B P; Kormos, R L; Borovetz, H S; Litwak, P; Kameneva, M V; Choi, S; Burgreen, G W; Wagner, W R; Wu, Z; Antaki, J F

    1997-01-01

    Nimbus and the University of Pittsburgh (UOP) have continued the development of a totally implanted axial flow blood pump under the National Institutes of Health (NIH) Innovative Ventricular Assist System (IVAS) program. This 62 cc device has an overall length of 84 mm and an outer diameter of 34.5 mm. The inner diameter of the blood pump is 12 mm. It is being designed to be a totally implanted permanent device. A key achievement during the past year was the completion of the Model 2 pump design. Ten of these pumps have been fabricated and are being used to conduct in vitro and in vivo experiments to evaluate the performance of different materials and hydraulic components. Efforts for optimizing the closed loop speed control have continued using mathematical modeling, computer simulations, and in vitro and in vivo testing. New hydraulic blade designs have been tested using computational fluid dynamics (CFD) and flow visualization. A second generation motor was designed with improved efficiency. To support the new motor, a new motor controller fabricated as a surface mount PC board has been completed. The program is now operating under a formal QA system.

  1. Compliance with periodontal maintenance at the University of Pittsburgh: Retrospective analysis of 315 cases.

    PubMed

    Famili, Pouran; Short, Elizabeth

    2010-01-01

    Maintenance care is the most important part of periodontal treatment because maintenance - adherence to the schedule of recall dental appointments after treatment - is believed to be the key in preventing the recurrence of periodontal disease. This article is a retrospective analysis of 315 cases from the Department of Periodontics and Preventive Dentistry at the University of Pittsburgh to determine compliance with periodontal maintenance schedules over a two-year period. Following the completion of periodontal surgical treatment, patients were placed on a regimen of maintenance care that included recalls every three months, professional prophylaxis by the hygiene faculty, and repeated instructions in home self-care. Medical records and patient charts of 315 subjects were selected randomly and reviewed in terms of the patient's attending the scheduled recall visit. It was hypothesized that female subjects would show better compliance with the maintenance care regimen than male subjects, as suggested in the literature. Among the 315 subjects, 112 (54 women and 58 men) followed the recommended recall schedule; 30% ultimately returned for the three-month prophylaxis recall visit after the initial periodontal surgical appointment, and thus were considered to have complied with the suggested maintenance program. The investigators failed to reject the stated hypothesis that women would display better compliance than men (p = 0.3).

  2. New wastewater treatment facility at Wheeling-Pittsburgh Steel`s Steubenville East Coke Plant

    SciTech Connect

    Nodianos, M.J.; Goshe, A.J.

    1995-07-01

    With stricter wastewater regulatory limits on the horizon and a consent decree issued by the Federal Environmental Protection Agency, Wheeling-Pittsburgh Steel Corp. opted to upgrade the existing biological treatment plant and construct a terminal treatment plant for organic polishing at the Steubenville East Coke Plant. Prior to this project, three main sources were treated at the biological treatment plant prior to being discharged to the Ohio River, those being excess flushing liquor, benzol interceptor sump water from the light oil recovery plant and direct cooler condensate from the desulfurization facility. Additionally, storm water and other contaminated process waste streams are now treated at the plant along with the previously mentioned sources. Bio plant effluent is then treated at the newly constructed terminal treatment plant where it is passed through sand filters for solids removal and carbon filters where any remaining organic constituents are removed. The new system treats an average of 700,000 gal of wastewater per day, compared to 450,000 gal/day before modifications. As a result of the upgraded system, phenolic compounds and ammonias have been dramatically reduced in coke plant wastewater returning to the Ohio River.

  3. Economic impact and policy implications from urban shared transportation: The case of Pittsburgh's shared bike system.

    PubMed

    Pelechrinis, Konstantinos; Zacharias, Christos; Kokkodis, Marios; Lappas, Theodoros

    2017-01-01

    During the last years the number of cities that have installed and started operating shared bike systems has significantly increased. These systems provide an alternative and sustainable mean of transportation to the city dwellers. Apart from the energy sustainability benefits, shared bike systems can have a positive effect on residents' health, air quality and the overall condition of the currently crumbling road network infrastructure. Anecdotal stories and survey studies have also identified that bike lanes have a positive impact on local businesses. In this study, driven by the rapid adoption of shared bike systems by city governments and their potential positive effects on a number of urban life facets we opt to study and quantify the value of these systems. We focus on a specific aspect of this value and use evidence from the real estate market in the city of Pittsburgh to analyze the effect on dwellers' properties of the shared bike system installed in the city in June 2015. We use quasi-experimental techniques and find that the shared bike system led to an increase in the housing prices (both sales and rental prices) in the zip codes where shared bike stations were installed. We further bring into the light potential negative consequences of this impact (i.e., gentrification) and discuss/propose two public policies that can exploit the impact of the system for the benefit of both the local government as well as the city dwellers.

  4. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.

    PubMed

    Klunk, William E; Engler, Henry; Nordberg, Agneta; Wang, Yanming; Blomqvist, Gunnar; Holt, Daniel P; Bergström, Mats; Savitcheva, Irina; Huang, Guo-feng; Estrada, Sergio; Ausén, Birgitta; Debnath, Manik L; Barletta, Julien; Price, Julie C; Sandell, Johan; Lopresti, Brian J; Wall, Anders; Koivisto, Pernilla; Antoni, Gunnar; Mathis, Chester A; Långström, Bengt

    2004-03-01

    This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p = 0.0001). Large increases also were observed in parietal (1.71-fold, p = 0.0002), temporal (1.52-fold, p = 0.002), and occipital (1.54-fold, p = 0.002) cortex and the striatum (1.76-fold, p = 0.0001). PIB retention was equivalent in AD patients and controls in areas known to be relatively unaffected by amyloid deposition (such as subcortical white matter, pons, and cerebellum). Studies in three young (21 years) and six older healthy controls (69.5 +/- 11 years) showed low PIB retention in cortical areas and no significant group differences between young and older controls. In cortical areas, PIB retention correlated inversely with cerebral glucose metabolism determined with 18F-fluorodeoxyglucose. This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.

  5. Reliability and validity of the Brazilian version of the Pittsburgh Sleep Quality Index in adolescents.

    PubMed

    Passos, Muana H P; Silva, Hítalo A; Pitangui, Ana C R; Oliveira, Valéria M A; Lima, Alaine S; Araújo, Rodrigo C

    To evaluate the reliability and validity of the Brazilian version of the Pittsburgh Sleep Quality Index. 309 adolescents, subdivided into a sample of 209 subjects, of whom 25 were reassessed, and another sample of 100 adolescents. Reliability was assessed using Cronbach's α-values, intraclass correlation coefficient, Standard Error of Measure, Minimum Detectable Change, and Bland-Altman plotting. Exploratory analysis of the questionnaire components was performed based on the sample of 209 adolescents. Confirmatory factor analysis was performed with a sample of 100 individuals. The sample of 209 participants had a mean age of 14.38 (±1.94) years, comprising 80 (38.3%) girls and 129 (61.7%) boys. The sample of 100 adolescents had a mean age of 13.66 (±2.35) years, comprising 51 (51%) girls and 49 (49%) boys. The questionnaire obtained a Standard Error of Measure=1.12 and Minimum Detectable Change=3.10. Cronbach's α was 0.71 and the Intraclass Correlation Coefficient was 0.65 (95% CI: 0.21-0.85). The factor analysis showed that the best model of components was the one that consisted of two factors, excluding the component on the use of sleep medications. The questionnaire showed high internal consistency and moderate reliability. Furthermore, a model with two factors seems to be the most appropriate to evaluate the quality of sleep in adolescents. Copyright © 2016 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.

  6. Pittsburgh Compound-B (PiB) binds amyloid β-protein protofibrils.

    PubMed

    Yamin, Ghiam; Teplow, David B

    2017-01-01

    The neuropathology of Alzheimer's disease (AD) includes amyloid plaque formation by the amyloid β-protein (Aβ) and intracellular paired helical filament formation by tau protein. These neuropathogenetic features correlate with disease progression and have been revealed in brains of AD patients using positron emission tomography (PET). One of the most useful positron emission tomography imaging agents has been Pittsburgh Compound-B (PiB). However, since its introduction in 2002, substantial evidence has accumulated suggesting that Aβ oligomerization and protofibril formation, rather than fibril formation per se, may be the more important pathogenetic event in AD. Detecting protofibrils and oligomeric forms of Aβ thus may be of value. We report here the results of experiments to determine whether PiB binds to oligomers or protofibrils formed by Aβ40 and Aβ42. We observed strong binding to Aβ42 fibrils, significant binding to protofibrils, and weaker binding to Aβ42 oligomers. PiB also binds Aβ40 fibrils, but its binding to Aβ40 protofibrils and oligomers is substantially lower than for that observed for Aβ42.

  7. Lessons learned: the unintended consequences of policy decisions affecting maternity services for Pittsburgh's African Americans.

    PubMed

    Carson, Carolyn

    2007-01-01

    In the Pittsburgh region, as elsewhere, the Black infant mortality rate, reflecting overall health disparities, is higher than the rate for White babies. This study suggests that the answer to the infant mortality racial disparity question may lie partially in the characteristics and availability of prenatal care as well as broader changes in the social and economic environment. Numerous known risk factors associated with infant mortality have been present for as long as statistics have been recorded. Only wide ranging comprehensive programs will combat such factors as low income, education, teenage motherhood, unemployment, and inadequate housing. The other more specific factors of low birth weight and inadequate prenatal care, however, can be addressed by providing adequate prenatal care in a setting that is accessible and designed specifically with the cultural awareness and concerns of the African American community in mind. The strategies of fifty years ago offer some insights that are worth noting as policy planners begin to design and implement new programs to combat the continuing tragedy of African American infant mortality.

  8. Validation of the Pittsburgh sleep quality index in community dwelling Ethiopian adults.

    PubMed

    Salahuddin, Mohammed; Maru, Tarekegn Tesfaye; Kumalo, Abera; Pandi-Perumal, Seithikurippu R; Bahammam, Ahmed S; Manzar, Md Dilshad

    2017-03-27

    The applicability of the Pittsburgh Sleep Quality Index (PSQI) in screening of insomnia is demonstrated in various populations. But, the tool has not been validated in a sample of Ethiopians. Therefore, this study aimed to assess its psychometric properties in community dwelling Ethiopian adults. Participants (n = 311, age = 25.5 ± 6.0 years and body mass index = 22.1 ± 2.3 kg/m(2)) from Mizan-Aman town, Southwest Ethiopia completed the PSQI and a semi-structured questionnaire for socio-demographics. Clinical interview for screening of insomnia according to the International Classification of Sleep Disorders was carried out as a concurrent validation measure. Overall, the PSQI scale did not have floor effect and ceiling effects. Moderate internal consistency (Cronbach's alpha was 0.59) and sufficient internal homogeneity as indicated by correlation coefficient between component scores and the global PSQI score was found. The PSQI was of good value for screening insomnia with optimal cut-off scores of 5.5 (sensitivity 82%, specificity 56.2%) and the area under the curve, 0.78 (p < 0.0001). The PSQI has unidimensional factor structure in the Ethiopian community adults for screening insomnia. The PSQI has good psychometric validity in screening for insomnia among Ethiopians adults.

  9. Stream reconnaissance for nutrients and other water-quality parameters, Greater Pittsburgh Region, Pennsylvania

    USGS Publications Warehouse

    Beall, Robert M.

    1975-01-01

    Eighty-five stream sites in and near the six-county Greater Pittsburgh Region were sampled in mid-June 1971 in mid-October 1972. Data are reported for 89 sites because 4 substitute sites were sampled in the second period. Drainage areas of the basins sampled ranged from 4.1 to 19,5000 square miles (10.6 to 50,500 square kilometres). The chemical analyses included constituents of three general classes: (1) nutrients, (2) activity indicators, and (3) dominant anions. Modification of the natural chemical and physical characteristics of the surface waters by man's activities is evident in some of the data. However, the activities are so diverse in type and in areal extent that their influence in terms of cause and effect is often obscure. Nutrient concentrations were high enough to indicate potential problems at about a quarter of the sampling sites. Temperature, dissolved oxygen, and pH values indicated a generally favorable capacity for regeneration or recovery from degradation, although a number a streams east of the Allegheny and Monongahela Rivers are marginal or lacking in the capacity. Regionally, sulfate is the dominant ion and was observed in concentrations of 40 milligrams per litre or more at 90 percent of the sites. Bicarbonate exceeded 100 milligrams per litre at 22 sites. A moderate to high degree of mineralization, as indicated by conductance readings of more than 500 micromhos per cetrimetre at half of the sampling sites, is a characteristic of the region's surface waters.

  10. Health hazard evaluation report No. HETA 90-010-2170, LTV Steel Company, Pittsburgh, Pennsylvania

    SciTech Connect

    Kinnes, G.M.; Letts, D.

    1991-12-01

    In response to a request from the United Steelworkers of America, an investigation was made of possible causative agents for allergic contact dermatitis in workers who clean the coke oven gas inlets at the LTV Steel Company (SIC-3312), Pittsburgh, Pennsylvania. The LTV Steel coke oven facility consists of five batteries, with a total of 315 by-product ovens. Almost 3 years ago a skin problem of potential occupational origin was identified among the heaters, helpers and patchers. A list of 26 workers with skin problems was developed by the union and management and provided to NIOSH investigators. The suspected causative agent was a condensate from coke oven underfiring gas which collected on gas nozzle seats in the gas heating pipes of specific batteries. The nine employees diagnosed as having occupational allergic contact dermatitis tested positive to at least one of the coke oven gas condensate fractions. Many compounds were identified in the condensate sample. The authors conclude that the dermatitis in some workers was probably caused by contact with the coke oven gas condensates. The authors recommend measures intended to prevent contact with the condensates.

  11. Guide to the availability of hydrologic data, Greater Pittsburgh region, Pennsylvania

    USGS Publications Warehouse

    Beall, Robert M.

    1976-01-01

    A great variety of hydrologic data are collected by many governmental agencies and other entities for diverse purposes. Some of the data are compiled and reported in readily available, widely known publications; some are not. Continuing requests for information on the locations of data collection sites and on the sources of data have suggested the need for a guide to that information. Presently active primary-data-collection sites have been located on a map of the Greater Pittsburgh region (Allegheny, Armstrong, Beaver, Butler, Washington, and Westmoreland Counties in southwestern Pennsylvania), and the sources of data--by publication or responsible agency-have been described. Secondary data collection sites have not been shown on the map, but several agencies involved in this activity have been listed. Hydrologic data are collected at the following numbers of identified sites under the auspices of federal, state, and interstate organizations: Precipitation or temperature .......... 39 Surface-water stage or discharge ...... 82 Surface-water quality ................. 69 Ground-water levels ................... 7

  12. Reconstruction of the 1994 Pittsburgh Airplane Accident Using a Computer Simulation

    NASA Technical Reports Server (NTRS)

    Parks, Edwin K.; Bach, Ralph E., Jr.; Shin, Jae Ho

    1998-01-01

    On September 8, 1994, a Boeing 737-300 passenger airplane was on a downwind approach to the Pittsburgh International Airport at an altitude of 5000 feet above ground level (6000 feet MSL). While in a shallow left turn onto a downwind approach heading, the airplane crossed into the vortex trail of a Boeing 727 flying in the same approach pattern about 4 miles ahead. The B-737 airplane rolled and turned sharply to the left, exited the vortex wake and plunged into the ground. Weather was not a factor in the accident. The airplane was equipped with a 11+ channel digital Flight Data Recorder (FDR) and a multiple channel Cockpit Voice Recorder (CVR). Both recorders were recovered from the crash site and provided excellent data for the development of an accident scenario. Radar tracking of the two airplanes as well as the indicated air speed (IAS) perturbations clearly visible on the B-737 FDR recordings indicate that the upset was apparently initiated by the airplane's crossing into the wake of the B-727 flying ahead in the same traffic pattern. A 6 degree-of-freedom simulation program for the B-737 airplane using MATLAB and SIMULINK was constructed. The simulation was initialized at the stabilized flight conditions of the airplane about 13 seconds prior to its entry into the vortex trail of the B-727 airplane. By assuming a certain combination of control inputs, it was possible to produce a simulated motion that closely matched that recorded on the FDR.

  13. Preferred Physical Characteristics of Vaginal Film Microbicides for HIV Prevention in Pittsburgh Women.

    PubMed

    Fan, Maria D; Kramzer, Lindsay F; Hillier, Sharon L; Chang, Judy C; Meyn, Leslie A; Rohan, Lisa C

    2017-05-01

    Unprotected heterosexual intercourse is the leading cause of HIV acquisition in women. Due to the complex nature of correct and consistent condom use by both men and women, developing alternative female-controlled HIV prevention options is a global health priority. Vaginal films containing antiretroviral drugs are a potential delivery system for the prevention of HIV acquisition through sexual contact. In this study, we explored women's preferences regarding physical characteristics of microbicide vaginal films through questionnaires and focus groups. Eighty-four sexually active, ethnically diverse women 18-30 years of age from Pittsburgh, Pennsylvania, participated in the study. Women visually and manually examined a variety of vaginal films, as well as three other vaginal products undergoing evaluation for HIV prevention: tablet, ring, and gel. Means and standard deviations or frequencies and 95 % confidence intervals were calculated for questionnaire data. Focus groups were audio-recorded, transcribed verbatim, and coded for content analysis. Women most frequently preferred vaginal films to be smooth and thin (63 %), translucent (48 %), and 2″ × 2″ square size (36 %). Driving these preferences were five major themes: ease and accuracy of use, desire for efficacy, discretion, intravaginal comfort and minimal impact, and minimizing disruption of sexual mood/activities. Women's preferences for various microbicide vaginal film physical attributes represented a balance of multiple values. In general, women desired a comfortable, efficacious, easy to use, and minimally intrusive product.

  14. Clinicopathologic and 11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer’s disease spectrum

    PubMed Central

    Lowe, Val J.; Graff-Radford, Neill R.; Liesinger, Amanda M.; Cannon, Ashley; Przybelski, Scott A.; Rawal, Bhupendra; Parisi, Joseph E.; Petersen, Ronald C.; Kantarci, Kejal; Ross, Owen A.; Duara, Ranjan; Knopman, David S.; Jack, Clifford R.; Dickson, Dennis W.

    2015-01-01

    Thal amyloid phase, which describes the pattern of progressive amyloid-β plaque deposition in Alzheimer’s disease, was incorporated into the latest National Institute of Ageing – Alzheimer’s Association neuropathologic assessment guidelines. Amyloid biomarkers (positron emission tomography and cerebrospinal fluid) were included in clinical diagnostic guidelines for Alzheimer’s disease dementia published by the National Institute of Ageing – Alzheimer’s Association and the International Work group. Our first goal was to evaluate the correspondence of Thal amyloid phase to Braak tangle stage and ante-mortem clinical characteristics in a large autopsy cohort. Second, we examined the relevance of Thal amyloid phase in a prospectively-followed autopsied cohort who underwent ante-mortem 11C-Pittsburgh compound B imaging; using the large autopsy cohort to broaden our perspective of 11C-Pittsburgh compound B results. The Mayo Clinic Jacksonville Brain Bank case series (n = 3618) was selected regardless of ante-mortem clinical diagnosis and neuropathologic co-morbidities, and all assigned Thal amyloid phase and Braak tangle stage using thioflavin-S fluorescent microscopy. 11C-Pittsburgh compound B studies from Mayo Clinic Rochester were available for 35 participants scanned within 2 years of death. Cortical 11C-Pittsburgh compound B values were calculated as a standard uptake value ratio normalized to cerebellum grey/white matter. In the high likelihood Alzheimer’s disease brain bank cohort (n = 1375), cases with lower Thal amyloid phases were older at death, had a lower Braak tangle stage, and were less frequently APOE-ε4 positive. Regression modelling in these Alzheimer’s disease cases, showed that Braak tangle stage, but not Thal amyloid phase predicted age at onset, disease duration, and final Mini-Mental State Examination score. In contrast, Thal amyloid phase, but not Braak tangle stage or cerebral amyloid angiopathy predicted 11C-Pittsburgh compound

  15. Clinicopathologic and 11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer's disease spectrum.

    PubMed

    Murray, Melissa E; Lowe, Val J; Graff-Radford, Neill R; Liesinger, Amanda M; Cannon, Ashley; Przybelski, Scott A; Rawal, Bhupendra; Parisi, Joseph E; Petersen, Ronald C; Kantarci, Kejal; Ross, Owen A; Duara, Ranjan; Knopman, David S; Jack, Clifford R; Dickson, Dennis W

    2015-05-01

    Thal amyloid phase, which describes the pattern of progressive amyloid-β plaque deposition in Alzheimer's disease, was incorporated into the latest National Institute of Ageing - Alzheimer's Association neuropathologic assessment guidelines. Amyloid biomarkers (positron emission tomography and cerebrospinal fluid) were included in clinical diagnostic guidelines for Alzheimer's disease dementia published by the National Institute of Ageing - Alzheimer's Association and the International Work group. Our first goal was to evaluate the correspondence of Thal amyloid phase to Braak tangle stage and ante-mortem clinical characteristics in a large autopsy cohort. Second, we examined the relevance of Thal amyloid phase in a prospectively-followed autopsied cohort who underwent ante-mortem (11)C-Pittsburgh compound B imaging; using the large autopsy cohort to broaden our perspective of (11)C-Pittsburgh compound B results. The Mayo Clinic Jacksonville Brain Bank case series (n = 3618) was selected regardless of ante-mortem clinical diagnosis and neuropathologic co-morbidities, and all assigned Thal amyloid phase and Braak tangle stage using thioflavin-S fluorescent microscopy. (11)C-Pittsburgh compound B studies from Mayo Clinic Rochester were available for 35 participants scanned within 2 years of death. Cortical (11)C-Pittsburgh compound B values were calculated as a standard uptake value ratio normalized to cerebellum grey/white matter. In the high likelihood Alzheimer's disease brain bank cohort (n = 1375), cases with lower Thal amyloid phases were older at death, had a lower Braak tangle stage, and were less frequently APOE-ε4 positive. Regression modelling in these Alzheimer's disease cases, showed that Braak tangle stage, but not Thal amyloid phase predicted age at onset, disease duration, and final Mini-Mental State Examination score. In contrast, Thal amyloid phase, but not Braak tangle stage or cerebral amyloid angiopathy predicted (11)C-Pittsburgh compound B

  16. Insights into the chemistry of new particle formation and growth events in Pittsburgh based on aerosol mass spectrometry.

    PubMed

    Zhang, Qi; Stanier, Charles O; Canagaratna, Manjula R; Jayne, John T; Worsnop, Douglas R; Pandis, Spyros N; Jimenez, Jose L

    2004-09-15

    New particle formation and growth events have been observed in several urban areas and are of concern due to their potential negative effects on human health. The main purpose of this study was to investigate the chemistry of ultrafine particles during the growth phase of the frequently observed nucleation events in Pittsburgh (approximately 100 events per year) and therefore infer the mechanisms of new particle growth in the urban troposphere. An Aerodyne aerosol mass spectrometer (AMS) and two SMPS systems were deployed at the U.S. EPA Pittsburgh Supersite during September 2002. Significant nucleation events were observed in 3 out of the 16 days of this deployment, including one of the 10 strongest nucleation events observed in Pittsburgh over a period of 15 months. These events appear to be representative of the climatology of new particle formation and growth in the Pittsburgh region. Distinctive growth of sulfate, ammonium, organics, and nitrate in the ultrafine mode (33-60 nm in a vacuum aerodynamic diameter or approximately 18-33 nm in physical diameter) was observed during each of these three events, with sulfate always being the first (and the fastest) species to increase. Ultrafine ammonium usually increased 10-40 min later than sulfate, causing the ultrafine mode particles to be more acidic during the initial stages of the nucleation events. Significant increase of ultrafine organics often happened after 11:00 a.m., when photochemistry is more intense. This observation coupled with a parallel increase of ultrafine m/z 44, a mass fragment generally representative of oxygenated organic compounds, indicates that secondary organic species contribute significantly to the growth of particles at a relatively later time of the event. Among all these four species, nitrate was always a minor component of the ultrafine particles and contributed the least to the new particle growth.

  17. 78 FR 4967 - Pennsylvania Disaster #PA-00057

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-23

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00057 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... locations. The following areas have been determined to be adversely affected by the disaster:...

  18. 78 FR 60366 - Pennsylvania Disaster #PA-00064

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-01

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster PA-00064 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... Application Deadline Date: 06/24/2014. ADDRESSES: Submit completed loan applications to: U.S. Small...

  19. 32 CFR 701.113 - PA exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.113 PA exemptions. (a) Exempt systems of records. 5 U.S.C. 552a authorizes SECNAV to adopt rules designating eligible systems of records as exempt from... responsible for proposing an exemption rule. Exempt systems of records are identified at...

  20. 76 FR 5647 - Pennsylvania Disaster #PA-00036

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-01

    ... ADMINISTRATION Pennsylvania Disaster PA-00036 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Pennsylvania dated 01/25/2011. Incident: Apartment Building Fire. Incident Period: 01/10/2011. Effective Date:...

  1. 77 FR 65044 - Pennsylvania Disaster #PA-00054

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-24

    ... ADMINISTRATION Pennsylvania Disaster PA-00054 AGENCY: U.S. Small Business Administration. ACTION: Notice SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Pennsylvania dated 10/18/2012. Incident: Cheltenham Township Condominium Complex Fire. Incident Period:...

  2. 75 FR 2165 - Pennsylvania Disaster #PA-00030

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-14

    ... ADMINISTRATION Pennsylvania Disaster PA-00030 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Pennsylvania dated 01/07/2010. Incident: Bellefonte Borough Apartment Complex Fire. Incident Period:...

  3. 77 FR 60004 - Pennsylvania Disaster #PA-00053

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... ADMINISTRATION Pennsylvania Disaster PA-00053 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Pennsylvania dated 09/21/2012. Incident: Apartment Building Fire in Bellefonte Borough. Incident Period:...

  4. Allegheny County, PA: Mobilizing To Reduce Juvenile Crime.

    ERIC Educational Resources Information Center

    Hsia, Heidi M.

    Juvenile crime and its immediate and long-term economic and human costs have become a national concern. Programs to prevent and reduce delinquency have developed across the country and one such program in Allegheny County, Pennsylvania (which includes Pittsburgh) is described in this bulletin. The Allegheny program exemplifies a large-scale,…

  5. Confirmatory Factor Analysis of the Pittsburgh Sleep Quality Index in Women with Hot Flashes

    PubMed Central

    Otte, Julie L.; Rand, Kevin L.; Landis, Carol A.; Paudel, Misti L.; Newton, Katherine M.; Woods, Nancy; Carpenter, Janet S.

    2015-01-01

    Objective Women report poor sleep quality during various stages of the menopause transition and post-menopause, especially those with hot flashes. Sleep measurements vary widely due to the copious instruments available. The Pittsburgh Sleep Quality Index (PSQI) is a frequently used questionnaire that produces a single score for sleep quality. This one-factor structure has not received consistent support in the literature. The goal of this analysis was to determine the best factor structure of the PSQI in women with hot flashes. Methods A confirmatory factor analysis was conducted on the PSQI baseline data from three randomized controlled clinical trials enrolling peri- and postmenopausal women with hot flashes (N=849) from the Menopause Strategies: Finding Lasting Answers for Symptoms and Health (MsFLASH) network. Several a priori factor models were compared. Results One- and two-factor models did not fit the data. A three-factor model comprising Sleep Efficiency, Perceived Sleep Quality, and Daily Disturbance showed good fit; however, the sleep medication item was dropped due to poor fit and low rates of sleep medication use. The three-factor model was examined in African American (AA) and Caucasian subsamples and found to be similar in both groups; however, two items showed small group differences in strength as indicators. Conclusions Sleep quality in midlife women with hot flashes, as measured by the PSQI, appears to comprise three correlated factors. Minor measurement differences detected between groups are of research interest, but do not necessitate different scoring practices. Additional research is needed to further define sleep quality and its associations with health-related outcomes. PMID:25944520

  6. Confirmatory factor analysis of the Pittsburgh Sleep Quality Index in women with hot flashes.

    PubMed

    Otte, Julie L; Rand, Kevin L; Landis, Carol A; Paudel, Misti L; Newton, Katherine M; Woods, Nancy; Carpenter, Janet S

    2015-11-01

    Women, especially those with hot flashes, report poor sleep quality during various stages of the menopausal transition and postmenopause. Sleep measurements vary widely because of the copious instruments available. The Pittsburgh Sleep Quality Index (PSQI) is a frequently used questionnaire that produces a single score for sleep quality. This one-factor structure has not received consistent support in the literature. The goal of this analysis was to determine the best factor structure of the PSQI in women with hot flashes. A confirmatory factor analysis was conducted on PSQI baseline data from three randomized controlled clinical trials enrolling perimenopausal and postmenopausal women with hot flashes (N = 849) from the Menopause Strategies: Finding Lasting Answers for Symptoms and Health network. Several a priori factor models were compared. One-factor and two-factor models did not fit the data. A three-factor model comprising sleep efficiency, perceived sleep quality, and daily disturbance showed good fit; however, the sleep medication item was dropped because of poor fit and low rates of sleep medication use. The three-factor model was examined in African-American and white subsamples and was found to be similar in both groups; however, two items showed small group differences in strength as indicators. Sleep quality in midlife women with hot flashes, as measured by the PSQI, seems to comprise three correlated factors. Minor measurement differences detected between groups are of research interest but do not necessitate different scoring practices. Additional research is needed to further define sleep quality and its associations with health-related outcomes.

  7. Factor analysis of the Pittsburgh Sleep Quality Index in breast cancer survivors.

    PubMed

    Otte, Julie L; Rand, Kevin L; Carpenter, Janet S; Russell, Kathleen M; Champion, Victoria L

    2013-03-01

    Sleep is a significant problem in breast cancer survivors (BCS) and measured frequently using the Pittsburgh Sleep Quality Index (PSQI). Thus, it is important to evaluate its factor structure. The two-process model of sleep regulation was the theoretical framework for this study. To perform a confirmatory factor analysis of the PSQI in BCS and compare results between African-American and Caucasian BCS. This was a secondary analysis of cross-sectional data using local and regional health care facilities and Eastern Cooperative Oncology Group referrals. The study included 1174 nondepressed BCS (90% Caucasian), with a mean age of 57 years and median PSQI global scores at the cutoff for poor sleep (median=6.00, interquartile range=4.00-9.00). Measurements included self-reported demographics, medical history, depression, and sleep. Acceptable fit was not reached for the traditional one-factor model that would be consistent with current PSQI scoring or for alternative models in the published literature from other populations. A new two-factor model (i.e., sleep efficiency and perceived sleep quality) best fit the data but nested-model comparisons by race showed different relationships by race for 1) sleep quality-sleep latency and 2) sleep efficiency-sleep quality. Results were inconsistent with current PSQI scoring that assumes a single global factor and with previously published literature. Although a new two-factor model best fit the data, further quantitative and qualitative analyses are warranted to validate our results in other populations before revising PSQI scoring recommendations. Additional recommendations are described for research. Copyright © 2013 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.

  8. Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-B.

    PubMed

    Butters, Meryl A; Klunk, William E; Mathis, Chester A; Price, Julie C; Ziolko, Scott K; Hoge, Jessica A; Tsopelas, Nicholas D; Lopresti, Brian J; Reynolds, Charles F; DeKosky, Steven T; Meltzer, Carolyn C

    2008-01-01

    There is increasing evidence for an empiric link between late-life depression and Alzheimer disease (AD). The neuropathology of AD, previously only confirmed at autopsy, may now be detectable in vivo using selective imaging ligands for beta-amyloid. Positron emission tomography (PET) with [11C] 6-OH-BTA-1 [Pittsburgh Compound-B (PiB)] has shown high tracer retention in cortical areas in patients with clinical diagnoses of probable AD and low retention in age-matched controls. We also previously reported variable PiB retention in patients with mild cognitive impairment (MCI). In this study, we used PiB-PET to evaluate whether amyloid is present in elders with treated major depression, many of whom have persistent cognitive impairment. We evaluated 9 subjects with remitted major depression [3M: 6F, mean (SD) age=71.8(5.7) y]. Seven of the 9 depressed subjects also met criteria for the diagnosis of MCI. PiB-PET data from healthy elders [n=8; mean (SD) age=71.5(3.0) y] were used for comparison. PET was acquired with arterial sampling and PiB retention was quantified using magnetic resonance imaging-guided cortical regions and graphical analysis of time-activity data; arterial line failure led to exclusion of 1 depressed subject. The data demonstrated variably elevated PiB retention. PiB retention in the 2 depressed subjects with normal cognitive ability was in the range of nondepressed cognitively normal subjects. PiB retention in 3 of the 6 depressed subjects with MCI fell in the range of subjects with AD. PiB retention in the remaining 3 depressed subjects with cooccurring MCI was variable and generally was intermediate to the other subjects. Our findings are consistent with and supportive of the hypothesis that depression may herald the development of AD in some individuals.

  9. Genetic and environmental influences on different components of the Pittsburgh Sleep Quality Index and their overlap.

    PubMed

    Barclay, Nicola L; Eley, Thalia C; Buysse, Daniel J; Rijsdijk, Fruhling V; Gregory, Alice M

    2010-05-01

    To examine the extent to which genetic and environmental factors influence components of sleep quality; the degree to which these components co-occur; and genetic and environmental influences on this co-occurrence. Twin study. Population based twin registry across the U.K. Four hundred twenty monozygotic twins, 773 dizygotic twins, and 363 siblings (mode age = 20 years; range 18 to 27 years). N/A. The Pittsburgh Sleep Quality Index (PSQI) assessed 7 components of sleep quality which overlap to varying degrees. Genetic influence on individual components ranged from 0% to 47%. The remaining source of variance was non-shared environment, except for "sleep duration", for which shared environmental influences were important. Phenotypic correlations between components ranged from 0.22 to 0.61. Bivariate analyses indicated substantial overlap between genes influencing phenotypes (10 of 15 correlations were > or = 0.69); and in general, genetic influence accounted for roughly half the association (> 40% in 9 of 15 correlations). Non-shared environmental influences were in general less correlated across variables (11 of 15 were < 0.4), but owing to their greater influence on each variable, still accounted for roughly half of each association (> or = 40% in 12 of 15 correlations). Genetic and non-shared environmental factors are most important in explaining individual differences with regards to different components of sleep quality, although shared environment may influence sleep duration. The pattern of overlap in the genetic and environmental influences accounting for the associations between components of sleep quality is consistent with that seen in other areas of developmental psychopathology of general genes and specific non-shared environmental influences.

  10. Validity of the Pittsburgh Sleep Quality Index in Indian University Students

    PubMed Central

    Manzar, Md. Dilshad; Moiz, Jamal A.; Zannat, Wassilatul; Spence, David W.; Pandi-Perumal, Seithikurippu R.; Hussain, M. Ejaz

    2015-01-01

    Objectives Despite the demonstrated utility of the Pittsburgh Sleep Quality Index (PSQI) in various demographic groups, it has never been validated in a sample of Indian subjects. To extend and confirm the PSQI’s applicability for South Asian subjects, this preliminary study aimed to assess its psychometric and diagnostic validity in a sample of university students. Methods Forty-seven male students were recruited from Jamia Millia Islamia, a public central university in New Delhi, India. The mean age of the students was 23.4±3.9 years, and they had a mean body mass index (BMI) of 23.3±3.3kg/m2. The PSQI was administered to all subjects and overnight polysomnographic testing was carried out as a concurrent validation measure. Results Cronbach’s alpha for the questionnaire was found to be 0.736. Internal homogeneity was high, with the majority of correlations between questionnaire component scores and the summed global score being significant (p<0.010). Criterion validity-correlations between the PSQI global score and polysomnography (PSG) measures were low. However, the questionnaire component scores and the related polysomnographic measures did show some significant relationships. The optimal cut-off scores for distinguishing students with/without sleep problems was >6 and was generated using receiver operating characteristic curve analysis. The area under the curve, sensitivity, specificity, positive and negative likelihood ratios at the cut-off score were 0.838 (p<0.0001), 75.0%, 88.9%, 6.75, and 0.280, respectively. Conclusion The study found evidence that the PSQI had internal consistency, internal homogeneity, and diagnostic characteristics that compared well with PSG among a sample of young adult male students in India. This supports the applicability and certain aspects of the validity of the PSQI in the population. PMID:26171126

  11. Experience with multimodality telepathology at the University of Pittsburgh Medical Center.

    PubMed

    Pantanowitz, Liron; Wiley, Clayton A; Demetris, Anthony; Lesniak, Andrew; Ahmed, Ishtiaque; Cable, William; Contis, Lydia; Parwani, Anil V

    2012-01-01

    Several modes of telepathology exist including static (store-and-forward), dynamic (live video streaming or robotic microscopy), and hybrid technology involving whole slide imaging (WSI). Telepathology has been employed at the University of Pittsburgh Medical Center (UPMC) for over a decade at local, national, and international sites. All modes of telepathology have been successfully utilized to exploit our institutions subspecialty expertise and to compete for pathology services. This article discusses the experience garnered at UPMC with each of these teleconsultation methods. Static and WSI telepathology systems have been utilized for many years in transplant pathology using a private network and client-server architecture. Only minor clinically significant differences of opinion were documented. In hematopathology, the CellaVision(®) system is used to transmit, via email, static images of blood cells in peripheral blood smears for remote interpretation. While live video streaming has remained the mode of choice for providing immediate adequacy assessment of cytology specimens by telecytology, other methods such as robotic microscopy have been validated and shown to be effective. Robotic telepathology has been extensively used to remotely interpret intra-operative neuropathology consultations (frozen sections). Adoption of newer technology and increased pathologist experience has improved accuracy and deferral rates in teleneuropathology. A digital pathology consultation portal (https://pathconsult.upmc.com/) was recently created at our institution to facilitate digital pathology second opinion consults, especially for WSI. The success of this web-based tool is the ability to handle vendor agnostic, large image files of digitized slides, and ongoing user-friendly customization for clients and teleconsultants. It is evident that the practice of telepathology at our institution has evolved in concert with advances in technology and user experience. Early and

  12. Description of interview data regarding Pittsburgh and confluence toxic chemical accidents

    SciTech Connect

    Rogers, G.O.; Shumpert, B.L.; Sorensen, J.H.

    1990-11-01

    Evacuation is the protective action most often recommended in response to chemical releases in the United States. The appropriateness of a decision to evacuate depends on whether the affected areas can be cleared of residents before it is contaminated by the chemical release. In determining whether an evacuation can be completed in time, emergency officials must consider both technical and behavioral aspects. The technical components can be readily conceived and quantified. In contrast, the behavioral components are much more abstract and more difficult to estimate. This report summarizes the univariate analysis of responses to surveys conducted in two communities where evacuation was recommended following train derailments involving hazardous chemicals. The surveys were designed to identify the actions taken by residents upon receiving the emergency warning; determine when people received the warning, decided to take action, and implemented the action; and ascertain factors that might explain the nature and timing of their actions. The surveys were conducted in the Bloomfield section of Pittsburgh, Pennsylvania, and in the town of Confluence, Pennsylvania. The study confirms that compliance with an emergency warning to evacuate varies and that potentially dangerous delays can be expected. Significant differences were noted, however, in the rate and speed of compliance in the two communities. The surveys provide information on several factors that may be useful in determining the reasons for differences in the responses from the two communities as well as differences among individual respondents. Such factors include the time of day when the accident occurred, where the respondent was at the time, whether the family was together, previous disaster experience, pet ownership, the content of the warning message, and demographic characteristics. 4 refs., 4 figs., 18 tabs.

  13. Imaging Alzheimer Pathology in Late-Life Depression With PET and Pittsburgh Compound-B

    PubMed Central

    Butters, Meryl A.; Klunk, William E.; Mathis, Chester A.; Price, Julie C.; Ziolko, Scott K.; Hoge, Jessica A.; Tsopelas, Nicholas D.; Lopresti, Brian J.; Reynolds, Charles F.; DeKosky, Steven T.; Meltzer, Carolyn C.

    2009-01-01

    There is increasing evidence for an empiric link between late-life depression and Alzheimer disease (AD). The neuropathology of AD, previously only confirmed at autopsy, may now be detectable in vivo using selective imaging ligands for β-amyloid. Positron emission tomography (PET) with [11C] 6-OH-BTA-1 [Pittsburgh Compound-B (PiB)] has shown high tracer retention in cortical areas in patients with clinical diagnoses of probable AD and low retention in age-matched controls. We also previously reported variable PiB retention in patients with mild cognitive impairment (MCI). In this study, we used PiB-PET to evaluate whether amyloid is present in elders with treated major depression, many of whom have persistent cognitive impairment. We evaluated 9 subjects with remitted major depression [3M: 6F, mean (SD) age=71.8(5.7) y]. Seven of the 9 depressed subjects also met criteria for the diagnosis of MCI. PiB-PET data from healthy elders [n=8; mean (SD) age=71.5(3.0) y] were used for comparison. PET was acquired with arterial sampling and PiB retention was quantified using magnetic resonance imaging-guided cortical regions and graphical analysis of time-activity data; arterial line failure led to exclusion of 1 depressed subject. The data demonstrated variably elevated PiB retention. PiB retention in the 2 depressed subjects with normal cognitive ability was in the range of nondepressed cognitively normal subjects. PiB retention in 3 of the 6 depressed subjects with MCI fell in the range of subjects with AD. PiB retention in the remaining 3 depressed subjects with cooccurring MCI was variable and generally was intermediate to the other subjects. Our findings are consistent with and supportive of the hypothesis that depression may herald the development of AD in some individuals. PMID:18580591

  14. Imaging brain amyloid in nondemented young adults with Down syndrome using Pittsburgh compound B.

    PubMed

    Handen, Benjamin L; Cohen, Ann D; Channamalappa, Umapathy; Bulova, Peter; Cannon, Sheila A; Cohen, William I; Mathis, Chester A; Price, Julie C; Klunk, William E

    2012-11-01

    Down syndrome (DS) is one of the most common causes of intellectual disability. Although DS accounts for only 15% of all individuals with intellectual disabilities, adults with DS account for approximately 60% of individuals with intellectual disabilities and Alzheimer's disease. This is thought to be because of overproduction of the β-amyloid (Aβ) protein due to trisomy for the Aβ precursor protein gene on chromosome 21. Pittsburgh compound B (PiB) is a noninvasive in vivo positron emission tomography tracer used to image amyloid deposition in living humans. Studies using PiB have shown an age-dependent asymptomatic amyloid deposition in more than 20% of the cognitively normal elderly population. Presymptomatic carriers of presenilin (PS-1) and Aβ precursor protein gene mutations who are destined to develop Alzheimer's disease also show preclinical amyloid deposition. This report describes a pilot study involving the use of PiB in seven adults with DS (age: 20-44 years). Compared with objective cutoffs for amyloid positivity in older non-DS cognitively normal control subjects, only two of the seven DS subjects (age: 38 and 44 years) showed increased PiB retention. The remaining five subjects aged between 20 and 35 years showed no detectable increase in PiB retention. Interestingly, the two subjects who showed elevated PiB retention showed a striatal-predominant pattern similar to that previously reported for PS-1 mutation carriers. These results demonstrate the feasibility of conducting PiB positron emission tomography scanning in this special population, and suggest a link between Aβ overproduction and early striatal deposition of fibrillar Aβ. Copyright © 2012 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

  15. Imaging brain amyloid in nondemented young adults with Down syndrome using Pittsburgh compound B

    PubMed Central

    Handen, Benjamin L.; Cohen, Ann D.; Channamalappa, Umapathy; Bulova, Peter; Cannon, Sheila A.; Cohen, William I.; Mathis, Chester A.; Price, Julie C.; Klunk, William E.

    2012-01-01

    Down syndrome (DS) is one of the most common causes of intellectual disability. Although DS accounts for only 15% of all individuals with intellectual disabilities, adults with DS account for approximately 60% of individuals with intellectual disabilities and Alzheimer’s disease. This is thought to be because of overproduction of the β-amyloid (Aβ) protein due to trisomy for the Aβ precursor protein gene on chromosome 21. Pittsburgh compound B (PiB) is a noninvasive in vivo positron emission tomography tracer used to image amyloid deposition in living humans. Studies using PiB have shown an age-dependent asymptomatic amyloid deposition in more than 20% of the cognitively normal elderly population. Presymptomatic carriers of presenilin (PS-1) and Aβ precursor protein gene mutations who are destined to develop Alzheimer’s disease also show preclinical amyloid deposition. This report describes a pilot study involving the use of PiB in seven adults with DS (age: 20–44 years). Compared with objective cutoffs for amyloid positivity in older non-DS cognitively normal control subjects, only two of the seven DS subjects (age: 38 and 44 years) showed increased PiB retention. The remaining five subjects aged between 20 and 35 years showed no detectable increase in PiB retention. Interestingly, the two subjects who showed elevated PiB retention showed a striatal-predominant pattern similar to that previously reported for PS-1 mutation carriers. These results demonstrate the feasibility of conducting PiB positron emission tomography scanning in this special population, and suggest a link between Aβ overproduction and early striatal deposition of fibrillar Aβ. PMID:23102120

  16. Reduced binding of Pittsburgh Compound-B in areas of white matter hyperintensities.

    PubMed

    Goodheart, A E; Tamburo, E; Minhas, D; Aizenstein, H J; McDade, E; Snitz, B E; Price, J C; Mathis, C A; Lopez, O L; Klunk, W E; Cohen, A D

    2015-01-01

    The amyloid imaging agent, Pittsburgh Compound-B, binds with high affinity to β-amyloid (Aβ) in the brain, and it is well established that PiB also shows non-specific retention in white matter (WM). However, little is known about retention of PiB in areas of white matter hyperintensities (WMH), abnormalities commonly seen in older adults. Further, it is hypothesized that WMH are related to both cognitive dysfunction and Aβ deposition. The goal of the present study was to explore PiB retention in both normal-appearing WM (NAWM) and WMH in a group of elderly, cognitively normal individuals. In a group of cognitively normal elderly (n = 64; 86.5 ± 2.6 years) two analyses were applied: (1) ROIs were placed over periventricular areas in which WMH caps are commonly seen on all subjects, regardless of WMH burden or size. (2) Subject-specific maps of NAWM and WMH were co-registered with the PiB-PET images and mean SUVR values were calculated in these NAWM and WMH maps. PiB retention was significantly reduced in the ROIs of subjects with high WMH compared to subjects with low WMH. Additionally, in subjects with high WMH, there was significantly lower PiB retention in subject-specific maps of WMH compared to NAWM, which was not observed in subjects with low WMH, likely because of the small size of WMH maps in this group. These data suggest that WM in areas of WMH binds PiB less effectively than does normal WM. Further exploration of this phenomenon may lead to insights about the molecular basis of the non-specific retention of amyloid tracers in white matter.

  17. (Pittsburgh Energy Technology Center): Quarterly technical progress report for the period ending December 31, 1986

    SciTech Connect

    Not Available

    1987-08-01

    In the Clean Coal Technology program, a series of fact-finding inquiries for the four proposals assigned to the Pittsburgh Energy Technology Center for negotiation was completed. Responses were received from each of the four proposers: Coal Tech Corp.; Ohio Ontario Clean Fuels, Inc.; Babcock and Wilcox; and Energy and Environmental Research Corp. All aspects of the Cooperative Agreement with Coal Tech Corp. were negotiated and the agreement was signed on December 24, 1986. Funding of the project, a demonstration of an advanced cyclone coal combustor, will be shared equally by DOE and Coal Tech Corp. Negotiations concerning the three other clean coal projects are proceeding, with all agreements anticipated to be finalized by September 30, 1987. Research in flue gas cleanup technology continued to produce important results. A PETC researcher was issued a patent on October 6 for inventing an advanced flue gas cleanup process. Hydrate Addition at Low Temperature (HALT) technology is a relatively low-cost, retrofittable method to clean coal-fired flue gas. DOE is sponsoring a 5-MW/sub e/ proof-of-concept test of this technology at Ohio Edison's Toronto Station under contract with Dravo Corp. Also under PETC's Flue Gas Cleanup Program, the University of North Dakota Energy Research Center (UNDERC) has developed a highly effective sorbent furnace injection concept based on pressure hydrated lime for SO/sub 2/ emissions control. As part of its contract with DOE to conduct proof-of-concept testing of the PETC Copper Oxide Process, UOP, Inc. has begun the first of two planned tests designed to determine the durability of the sorbent used in the process. The sorbent consists of aluminum oxide spheres impregnated with copper oxide. These tests will establish the long-term stability of the sorbent and provide data for scale-up of the process to the proof-of-concept level.

  18. The reliability and validity of the Korean version of the Pittsburgh Sleep Quality Index.

    PubMed

    Sohn, Seung Il; Kim, Do Hyung; Lee, Mi Young; Cho, Yong Won

    2012-09-01

    The Pittsburgh Sleep Quality Index (PSQI) is a self-reported questionnaire that measures sleep quality during the previous month. The aims of this study were to analyze the reliability and validity of the Korean version of the PSQI (PSQI-K) and to evaluate its usefulness. We developed the PSQI-K, which involved translating the original PSQI into Korean and then translating back into English to check its accuracy. We tested the validity of the PSQI-K on a total of 394 individuals: 261 with poor sleep (primary insomnia, n = 211; narcolepsy, n = 50) and 133 with good sleep. All subjects completed the PSQI-K, 285 had overnight nocturnal polysomnography, and 53 were randomly selected for a retest with the questionnaire after 2-4 weeks without any intervening treatment. The mean PSQI-K global scores in each group were analyzed after adjusting for age and sex. Cronbach's α coefficient for internal consistency of the total score of the PSQI-K was 0.84 which shows high reliability. Sensitivity and specificity for distinguishing poor and good sleepers were 0.943 and 0.844 using the best cutoff point of 8.5. The total and component scores of the PSQI-K for insomnia and narcolepsy were significantly higher than those for controls (p < 0.05). The test-retest correlation coefficient was 0.65 for the total score (p < 0.001). There was no significant difference between the two values using the paired t tests. The PSQI-K is a reliable and valid questionnaire for evaluating sleep quality in patients with sleep disorders.

  19. Postmortem Pittsburgh Compound B (PiB) binding increases with Alzheimer's disease progression.

    PubMed

    Beckett, Tina L; Webb, Robin L; Niedowicz, Dana M; Holler, Christopher J; Matveev, Sergey; Baig, Irfan; LeVine, Harry; Keller, Jeffrey N; Murphy, M Paul

    2012-01-01

    The development of imaging reagents is of considerable interest in the Alzheimer's disease (AD) field. Some of these, such as Pittsburgh Compound B (PiB), were designed to bind to the amyloid-β peptide (Aβ), the major component of amyloid deposits in the AD brain. Although these agents were designed for imaging amyloid deposits in vivo, a major avenue of evaluation relies on postmortem cross validation with established indices of AD pathology. In this study, we evaluated changes in the postmortem binding of PiB and its relationship to other aspects of Aβ-related pathology in a series of AD cases and age-matched controls. We also examined cases of preclinical AD (PCAD) and amnestic mild cognitive impairment (MCI), both considered early points in the AD continuum. PiB binding was found to increase with the progression of the disease and paralleled increases in the less soluble forms of Aβ, including SDS-stable Aβ oligomers. Increased PiB binding and its relationship to Aβ was only significant in a brain region vulnerable to the development of AD pathology (the superior and middle temporal gyri) but not in an unaffected region (cerebellum). This implies that the amyloid deposited in disease-affected regions may possess fundamental, brain region specific characteristics that may not as yet be fully appreciated. These data support the idea that PiB is a useful diagnostic tool for AD, particularly in the early stage of the disease, and also show that PiB could be a useful agent for the discovery of novel disease-related properties of amyloid.

  20. Racial differences in type of alcoholic beverage consumed during adolescence in the Pittsburgh Girls Study.

    PubMed

    Chung, Tammy; Pedersen, Sarah L; Kim, Kevin H; Hipwell, Alison E; Stepp, Stephanie D

    2014-01-01

    White, compared with Black, adolescents have higher rates of alcohol use and show more rapid increases in alcohol use. Racial differences in type of alcohol beverage (i.e., beer, wine, and liquor) consumed by youth have received scant attention, and little is known regarding changes in type of alcohol beverage consumed during adolescence, when experimentation may transition to more regular use. This study used repeated measures latent class analysis to identify distinct profiles that represent change in type of alcohol beverage consumed across ages 11 to 18 and to examine predictors (e.g., caretaker alcohol use, perceived peer alcohol use, ease in accessing alcohol, perceived neighborhood risk indicated by witnessing drug dealing), most of which were measured at ages 11 to 12, of alcohol use profiles in the Pittsburgh Girls Study (n = 2,171; 57% Black, 43% White), a community sample with annual follow-ups. Among Black girls, 2 profiles were identified: Low Use (76%), and Alcohol Use involving primarily liquor starting around age 15 (24%). Among White girls, 4 profiles were identified: Wine sippers (11%); a Low Use profile with low probability of drinking until age 18, when use of beer and liquor increased (52%); an Increasing Use profile with increased probability of drinking beer and liquor starting at age 15 (23%); and a High Alcohol Use profile, starting with use of wine, then shifting to use primarily of beer and liquor after age 13 (14%). Separate risk factor analyses conducted by race indicated similar predictors for Black and White girls: perceived ease in accessing alcohol, witnessing neighborhood drug dealing, and perceived peer alcohol use were each associated with heavier drinking profiles. Longitudinal profiles of type of alcoholic beverages, within and across racial groups, can guide the tailoring of interventions to address developmentally salient turning points in alcohol use for specific subgroups of girls. Copyright © 2013 by the Research Society

  1. Racial differences in type of alcoholic beverage consumed during adolescence in the Pittsburgh Girls Study

    PubMed Central

    Chung, Tammy; Pedersen, Sarah L.; Kim, Kevin H.; Hipwell, Alison E.; Stepp, Stephanie D.

    2013-01-01

    Background White, compared to Black, adolescents have higher rates of alcohol use, and show more rapid increases in alcohol use. Racial differences in type of alcohol beverage (i.e., beer, wine, liquor) consumed by youth have received scant attention, and little is known regarding changes in type of alcohol beverage consumed during adolescence, when experimentation may transition to more regular use. Methods This study used repeated measures latent class analysis to identify distinct profiles that represent change in type of alcohol beverage consumed across ages 11–18, and to examine predictors (e.g., caretaker alcohol use, perceived peer alcohol use, ease in accessing alcohol, perceived neighborhood risk indicated by witnessing drug dealing), most of which were measured at ages 11–12, of alcohol use profiles in the Pittsburgh Girls Study (n=2,171; 57% Black, 43% White), a community sample with annual follow-ups. Results Among Black girls, 2 profiles were identified: Low Use (76%), and Alcohol Use involving primarily liquor starting around age 15 (24%). Among White girls, 4 profiles were identified: Wine sippers (11%); a Low Use profile with low probability of drinking until age 18, when use of beer and liquor increased (52%); an Increasing Use profile with increased probability of drinking beer and liquor starting at age 15 (23%); and a High Alcohol Use profile, starting with use of wine, then shifting to use primarily of beer and liquor after age 13 (14%). Separate risk factor analyses conducted by race indicated similar predictors for Black and White girls: perceived ease in accessing alcohol, witnessing neighborhood drug dealing, and perceived peer alcohol use were each associated with heavier drinking profiles. Conclusions Longitudinal profiles of type of alcoholic beverages, within and across racial groups, can guide the tailoring of interventions to address developmentally salient turning points in alcohol use for specific subgroups of girls. PMID

  2. Psychometric Properties of the Pittsburgh Sleep Quality Index (PSQI) in a Cohort of Peruvian Pregnant Women.

    PubMed

    Zhong, Qiu-Yue; Gelaye, Bizu; Sánchez, Sixto E; Williams, Michelle A

    2015-08-15

    We sought to evaluate the construct validity and factor structure of the Spanish-language version of the Pittsburgh Sleep Quality Index (PSQI) among pregnant Peruvian women. A cohort of 642 women were interviewed at ≤ 16 weeks of gestation. During interview, we ascertained information about lifestyles, demographics, sleep characteristics, and mood symptoms. Stress induced sleep disturbance, depressive symptoms, and anxiety symptoms were evaluated using the Ford Insomnia Response to Stress Test (FIRST), Patient Health Questionnaire-9 (PHQ-9), and Generalized Anxiety Disorder-7 (GAD-7) assessment scales, respectively. Consistency indices, exploratory and confirmatory factor analyses, correlations, and logistic regressions were used. Both exploratory and confirmatory factor analyses indicated a three-factor solution: sleep quality, sleep efficiency, and sleep medication. We observed significantly positive correlations of the PSQI with the FIRST (0.42), the PHQ-9 (0.49), and the GAD-7 (0.46). Poor sleepers (PSQI global score > 5) had significantly increased odds of experiencing stress-induced sleep disturbance (odds ratio, OR = 3.57; 95% CI: 2.40, 5.31), depression (OR = 5.48; 95% CI: 3.58, 8.37), and generalized anxiety disorder (OR = 4.57; 95% CI: 3.08, 6.76). The Spanish-language version of the PSQI instrument was found to have good construct validity among pregnant Peruvian women. Consistent with some other studies, the PSQI was found to have a three-factor structure. Further assessment and validation studies are needed to determine whether the three, factor-specific scoring of the PSQI is favored over the PSQI global score in diverse populations. © 2015 American Academy of Sleep Medicine.

  3. Ethnic Differences in Positive Alcohol Expectancies During Childhood: The Pittsburgh Girls Study

    PubMed Central

    Chung, Tammy; Hipwell, Alison; Loeber, Rolf; White, Helene Raskin; Stouthamer-Loeber, Magda

    2008-01-01

    Background Positive expectancies about alcohol's effects are more likely to be endorsed with increasing age through adolescence, and the strength of positive alcohol expectancies in children appears to differ by ethnicity. Little is known about the extent to which differences in a measure's psychometric properties as a function of development and ethnicity may account for changes that are observed over time and ethnic differences. This study used measurement invariance methods to examine ethnic differences in the development of alcohol expectancies, and examined risk factors associated with girls’ positive expectancies. Methods African-American (56%) and Caucasian (44%) girls (n = 570) in the age 7 cohort of the Pittsburgh Girls Study, and the girl's primary caretaker, were followed annually for 4 years (ages 7−10). Girls reported on alcohol expectancies at each wave, and physical aggression at Year 1. In Year 1, caretakers reported on neighborhood drug use, their own substance-related problems, and depression in the girl. Structural equation modeling was used to examine measurement invariance of positive alcohol expectancies, and to test associations of risk factors to initial level and change in expectancies. Results Five of 8 positive alcohol expectancy items showed measurement equivalence for African-American and Caucasian girls in cross-sectional, but not longitudinal, analyses. Measurement equivalence over ages 7−10 was demonstrated for Caucasian girls, and over ages 7−8 and 9−10 (i.e., a two-part model) for African-American girls. Risk factor analyses indicated that, for Caucasian girls, greater physical aggression was associated with higher initial positive expectancies. Conclusions Some developmental change and ethnic differences in the performance of positive expectancy items were identified, highlighting the utility of measurement invariance methods. Risk factor analyses suggest the potential benefit of targeted alcohol prevention interventions

  4. Effect of PaCO2 and PaO2 on lidocaine and articaine toxicity.

    PubMed

    Barcelos, K C; Furtado, D P; Ramacciato, J C; Cabral, A M; Haas, D A

    2010-01-01

    Alterations in arterial PaCO₂ can influence local anesthetic toxicity. The objective of this study was to evaluate the effect of stress-induced changes in PaCO₂ and PaO₂ on the seizure threshold of lidocaine and articaine. Lidocaine (2% with 1 : 100,000 epinephrine) or articaine (4% with 1 : 100,000 epinephrine) was administered intravenously under rest or stress conditions to 36 rats separated into 4 groups. Propranolol and prazosin were administered preoperatively to minimize cardiovascular effects of epinephrine. Mean arterial pressure (MAP), heart rate (HR), and arterial pH, PaCO₂, and PaO₂ were measured. Results showed no differences in MAP, HR, or pH. Stress significantly increased the latency period for the first tonic-clonic seizure induced by a toxic dose of both lidocaine and articaine (P < .05). Seizures were brought on more rapidly by articaine. No significant difference between toxic doses of lidocaine and articaine was noted. Stress raised the seizure threshold dose for both drugs and significantly (P < .01) increased arterial PaO₂ from 94.0 ± 1.90 mm Hg to 113.0 ± 2.20 mm Hg, and reduced PaCO₂ from 36.0 ± 0.77 mm Hg to 27.0 ± 0.98 mm Hg. In conclusion, reduction in PaCO₂ and/or increase in PaO₂ raised the seizure threshold of lidocaine and articaine. This study also confirmed that lidocaine and articaine have equipotent central nervous system toxicity.

  5. Effect of PaCO2 and PaO2 on Lidocaine and Articaine Toxicity

    PubMed Central

    Barcelos, K.C; Furtado, D.P; Ramacciato, J.C; Cabral, A.M; Haas, D.A

    2010-01-01

    Alterations in arterial PaCO2 can influence local anesthetic toxicity. The objective of this study was to evaluate the effect of stress-induced changes in PaCO2 and PaO2 on the seizure threshold of lidocaine and articaine. Lidocaine (2% with 1 ∶ 100,000 epinephrine) or articaine (4% with 1 ∶ 100,000 epinephrine) was administered intravenously under rest or stress conditions to 36 rats separated into 4 groups. Propranolol and prazosin were administered preoperatively to minimize cardiovascular effects of epinephrine. Mean arterial pressure (MAP), heart rate (HR), and arterial pH, PaCO2, and PaO2 were measured. Results showed no differences in MAP, HR, or pH. Stress significantly increased the latency period for the first tonic-clonic seizure induced by a toxic dose of both lidocaine and articaine (P < .05). Seizures were brought on more rapidly by articaine. No significant difference between toxic doses of lidocaine and articaine was noted. Stress raised the seizure threshold dose for both drugs and significantly (P < .01) increased arterial PaO2 from 94.0 ± 1.90 mm Hg to 113.0 ± 2.20 mm Hg, and reduced PaCO2 from 36.0 ± 0.77 mm Hg to 27.0 ± 0.98 mm Hg. In conclusion, reduction in PaCO2 and/or increase in PaO2 raised the seizure threshold of lidocaine and articaine. This study also confirmed that lidocaine and articaine have equipotent central nervous system toxicity. PMID:20843225

  6. Technical Insights for Saltstone PA Maintenance

    SciTech Connect

    Flach, G.; Sarkar, S.; Mahadevan, S.; Kosson, D.

    2011-07-20

    The Cementitious Barriers Partnership (CBP) is a collaborative program sponsored by the US DOE Office of Waste Processing. The objective of the CBP is to develop a set of computational tools to improve understanding and prediction of the long-term structural, hydraulic, and chemical performance of cementitious barriers and waste forms used in nuclear applications. CBP tools are expected to better characterize and reduce the uncertainties of current methodologies for assessing cementitious barrier performance and increase the consistency and transparency of the assessment process, as the five-year program progresses. In September 2009, entering its second year of funded effort, the CBP sought opportunities to provide near-term tangible support to DOE Performance Assessments (PAs). The Savannah River Saltstone Disposal Facility (SDF) was selected for the initial PA support effort because (1) cementitious waste forms and barriers play a prominent role in the performance of the facility, (2) certain important long-term behaviors of cementitious materials composing the facility are uncertain, (3) review of the SDF PA by external stakeholders is ongoing, and (4) the DOE contractor responsible for the SDF PA is open to receiving technical assistance from the CBP. A review of the current (SRR Closure & Waste Disposal Authority 2009) and prior Saltstone PAs (e.g., Cook et al. 2005) suggested five potential opportunities for improving predictions. The candidate topics considered were (1) concrete degradation from external sulfate attack, (2) impact of atmospheric exposure to concrete and grout before closure, such as accelerated slag and Tc-99 oxidation, (3) mechanistic prediction of geochemical conditions, (4) concrete degradation from rebar corrosion due to carbonation, and (5) early age cracking from drying and/or thermal shrinkage. The candidate topics were down-selected considering the feasibility of addressing each issue within approximately six months, and

  7. Fluoranthene degradation in Pseudomonas alcaligenes PA-10.

    PubMed

    Gordon, L; Dobson, A D

    2001-01-01

    Pseudomonas alcaligenes strain PA-10 degrades the four-ring polycyclic aromatic hydrocarbon fluoranthene, co-metabolically. HPLC analysis of the growth medium identified four intermediates, 9-fluorenone-1-carboxylic acid; 9-hydroxy-1-fluorene carboxylic acid; 9-fluorenone and 9-fluorenol, formed during fluoranthene degradation. Pre-exposure of PA-10 to 9-fluorenone-1-carboxylic acid and 9-hydroxy-1-fluorene-carboxylic acid resulted in increases in fluoranthene removal, while pre-exposure to 9-fluorenone and 9-fluorenol resulted in a decrease in fluoranthene degradation. The rate of indole transformation was similarly affected by pre-exposure to these metabolic intermediates, indicating a link between fluoranthene degradation and indigo formation in this strain.

  8. Structure investigations of PP-PA blends

    NASA Astrophysics Data System (ADS)

    Janicki, Jaroslaw; Wlochowicz, Andrzej; Slusarczyk, Czeslaw

    1997-02-01

    In the paper we have used the SAXS method in order to determine the supermolecular structure parameters, including the transition layer thickness, of polypropylene/polyamide-6 (PP/PA) blends. The transition layer thickness has been obtained by means of two methods elaborated by Koberstein and co-workers and by Ruland, respectively. Both these methods assume that changes of the electron density in the transition region can be described by a Gaussian function with a standard deviation (sigma) . The parameter (sigma) have been determined graphically from the appropriate plots. Then, the thickness of the phase boundary E was estimated as (root)12(sigma) . The investigated PP/PA blends are multiphase systems and the problem of determination of the boundary width is more complicated because the meaning of Porod's law must be considered with caution. This problem is discussed based on wide range of the investigated samples prepared over various pressure and crystallization temperature conditions.

  9. {sup 231}Pa photofission cross section

    SciTech Connect

    Soldatov, A.S.; Rudnikov, V.E.; Smirenkin, G.N.

    1995-12-01

    The measurements of the {sup 231}Pa yield and cross section photofission in the energy range 7-9 MeV are presented. These measurements are a continuation of similar measurements performed for the {gamma}-ray energy range 4.8-7 MeV. The entire collection of experimental data which combine the results obtained in the present work and in Ref. 1 was analyzed.

  10. Graphs for Isotopes of 91-Pa (Protactinium)

    NASA Astrophysics Data System (ADS)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides a graphic representation of nucleon separation energies and residual interaction parameters for isotopes of the chemical element 91-Pa (Protactinium, atomic number Z = 91).

  11. Fidelity to Theory in PA Intervention Research.

    PubMed

    Keller, Colleen; Fleury, Julie; Sidani, Souraya; Ainsworth, Barbara

    2009-04-01

    Research using theory-based interventions to promote regular physical activity (PA) has increased substantially over the past decade. The purpose of this article is to provide a review and summary of PA intervention research specific to fidelity to intervention theory, providing an overview of the concept of fidelity to intervention theory, defining the evaluative components of fidelity: (a) conceptualization of the problem, (b) operationalization of the theory, (c) specification of mediating processes, and (d) specification of outcome variables. Using journal scans and computerized literature database searches, the authors identified 470 PA activity intervention studies that incorporated a theoretical perspective. A validity framework explicated by was used to summarize intervention research in light of fidelity to intervention theory. In all, 15 intervention studies met the inclusion criteria and were incorporated into the review. Theoretical models for health behavior change, including social cognitive theory (SCT), cognitive behavioral theory (CBT), the transtheoretical model (TTM, the TTM combined with SCT), the reversal theory (theory of psychological reversals), and the disconnected values theory, were used as a basis for intervention design and evaluation.

  12. Sensor Kinase PA4398 Modulates Swarming Motility and Biofilm Formation in Pseudomonas aeruginosa PA14

    PubMed Central

    Strehmel, Janine; Neidig, Anke; Nusser, Michael; Geffers, Robert; Brenner-Weiss, Gerald

    2014-01-01

    Pseudomonas aeruginosa is an opportunistic human pathogen that is able to sense and adapt to numerous environmental stimuli by the use of transcriptional regulators, including two-component regulatory systems. In this study, we demonstrate that the sensor kinase PA4398 is involved in the regulation of swarming motility and biofilm formation in P. aeruginosa PA14. A PA4398− mutant strain was considerably impaired in swarming motility, while biofilm formation was increased by approximately 2-fold. The PA4398− mutant showed no changes in growth rate, rhamnolipid synthesis, or the production of the Pel exopolysaccharide but exhibited levels of the intracellular second messenger cyclic dimeric GMP (c-di-GMP) 50% higher than those in wild-type cells. The role of PA4398 in gene regulation was investigated by comparing the PA4398− mutant to the wild-type strain by using microarray analysis, which demonstrated that 64 genes were up- or downregulated more than 1.5-fold (P < 0.05) under swarming conditions. In addition, more-sensitive real-time PCR studies were performed on genes known to be involved in c-di-GMP metabolism. Among the dysregulated genes were several involved in the synthesis and degradation of c-di-GMP or in the biosynthesis, transport, or function of the iron-scavenging siderophores pyoverdine and pyochelin, in agreement with the swarming phenotype observed. By analyzing additional mutants of selected pyoverdine- and pyochelin-related genes, we were able to show that not only pvdQ but also pvdR, fptA, pchA, pchD, and pchH are essential for the normal swarming behavior of P. aeruginosa PA14 and may also contribute to the swarming-deficient phenotype of the PA4398− mutant in addition to elevated c-di-GMP levels. PMID:25501476

  13. Proteasome activators, PA28γ and PA200, play indispensable roles in male fertility.

    PubMed

    Huang, Lin; Haratake, Kousuke; Miyahara, Hatsumi; Chiba, Tomoki

    2016-03-22

    Protein degradation mediated by the proteasome is important for the protein homeostasis. Various proteasome activators, such as PA28 and PA200, regulate the proteasome function. Here we show double knockout (dKO) mice of Psme3 and Psme4 (genes for PA28γ and PA200), but not each single knockout mice, are completely infertile in male. The dKO sperms exhibited remarkable defects in motility, although most of them showed normal appearance in morphology. The proteasome activity of the mutant sperms decreased notably, and the sperms were strongly positive with ubiquitin staining. Quantitative analyses of proteins expressed in dKO sperms revealed up-regulation of several proteins involved in oxidative stress response. Furthermore, increased 8-OHdG staining was observed in dKO sperms head, suggesting defective response to oxidative damage. This report verified PA28γ and PA200 play indispensable roles in male fertility, and provides a novel insight into the role of proteasome activators in antioxidant response.

  14. Proteasome activators, PA28γ and PA200, play indispensable roles in male fertility

    PubMed Central

    Huang, Lin; Haratake, Kousuke; Miyahara, Hatsumi; Chiba, Tomoki

    2016-01-01

    Protein degradation mediated by the proteasome is important for the protein homeostasis. Various proteasome activators, such as PA28 and PA200, regulate the proteasome function. Here we show double knockout (dKO) mice of Psme3 and Psme4 (genes for PA28γ and PA200), but not each single knockout mice, are completely infertile in male. The dKO sperms exhibited remarkable defects in motility, although most of them showed normal appearance in morphology. The proteasome activity of the mutant sperms decreased notably, and the sperms were strongly positive with ubiquitin staining. Quantitative analyses of proteins expressed in dKO sperms revealed up-regulation of several proteins involved in oxidative stress response. Furthermore, increased 8-OHdG staining was observed in dKO sperms head, suggesting defective response to oxidative damage. This report verified PA28γ and PA200 play indispensable roles in male fertility, and provides a novel insight into the role of proteasome activators in antioxidant response. PMID:27003159

  15. Health care reform in the USA: Recommendations from USA and non-USA radiologists.

    PubMed

    Burke, Lauren Mb; Martin, Diego R; Bader, Till; Semelka, Richard C

    2012-02-28

    To compare the opinions and recommendations of imaging specialists from United States (USA) and non-USA developed nations for USA health care reform. A survey was emailed out to 18 imaging specialists from 17 non-USA developed nation countries and 14 radiologists within the USA regarding health care reform. The questionnaire contained the following questions: what are the strengths of your health care system, what problems are present in your nation's health care system, and what recommendations do you have for health care reform in the USA. USA and non-USA radiologists received the same questionnaire. Strengths of the USA health care system include high quality care, autonomy, and access to timely care. Twelve of 14 (86%) USA radiologists identified medicolegal action as a major problem in their health care system and felt that medicolegal reform was a critical aspect of health care reform. None of the non-USA radiologists identified medicolegal aspects as a problem in their own country nor identified it as a subject for USA health care reform. Eleven of 14 (79%) USA radiologists and 16/18 (89%) non-USA radiologists identified universal health care coverage as an important recommendation for reform. Without full universal coverage, meaningful health care reform will likely require medicolegal reform as an early and important aspect of improved and efficient health care.

  16. Indoor air sampling for fine particulate matter and black carbon in industrial communities in Pittsburgh.

    PubMed

    Tunno, Brett J; Naumoff Shields, Kyra; Cambal, Leah; Tripathy, Sheila; Holguin, Fernando; Lioy, Paul; Clougherty, Jane E

    2015-12-01

    Impacts of industrial emissions on outdoor air pollution in nearby communities are well-documented. Fewer studies, however, have explored impacts on indoor air quality in these communities. Because persons in northern climates spend a majority of their time indoors, understanding indoor exposures, and the role of outdoor air pollution in shaping such exposures, is a priority issue. Braddock and Clairton, Pennsylvania, industrial communities near Pittsburgh, are home to an active steel mill and coke works, respectively, and the population experiences elevated rates of childhood asthma. Twenty-one homes were selected for 1-week indoor sampling for fine particulate matter (PM2.5) and black carbon (BC) during summer 2011 and winter 2012. Multivariate linear regression models were used to examine contributions from both outdoor concentrations and indoor sources. In the models, an outdoor infiltration component explained 10 to 39% of variability in indoor air pollution for PM2.5, and 33 to 42% for BC. For both PM2.5 models and the summer BC model, smoking was a stronger predictor than outdoor pollution, as greater pollutant concentration increases were identified. For winter BC, the model was explained by outdoor pollution and an open windows modifier. In both seasons, indoor concentrations for both PM2.5 and BC were consistently higher than residence-specific outdoor concentration estimates. Mean indoor PM2.5 was higher, on average, during summer (25.8±22.7 μg/m3) than winter (18.9±13.2 μg/m3). Contrary to the study's hypothesis, outdoor concentrations accounted for only little to moderate variability (10 to 42%) in indoor concentrations; a much greater proportion of PM2.5 was explained by cigarette smoking. Outdoor infiltration was a stronger predictor for BC compared to PM2.5, especially in winter. Our results suggest that, even in industrial communities of high outdoor pollution concentrations, indoor activities--particularly cigarette smoking--may play a larger

  17. Consideration of optimal time window for Pittsburgh compound B PET summed uptake measurements.

    PubMed

    McNamee, Rebecca L; Yee, Seong-Hwan; Price, Julie C; Klunk, William E; Rosario, Bedda; Weissfeld, Lisa; Ziolko, Scott; Berginc, Michael; Lopresti, Brian; Dekosky, Steven; Mathis, Chester A

    2009-03-01

    The standardized uptake value ratio (SUVR, or summed tissue ratio) has been used effectively in Pittsburgh compound B (PiB) PET studies to distinguish subjects who have significant amyloid-beta deposition in their brain from those who do not. Relative to quantitative measurements, advantages of the SUVR are improved study feasibility and low test-retest variation; disadvantages include inherent bias (PiB retention overestimation) and potential for time-varying outcomes. The PiB SUVR has proven to be highly correlated with quantitative outcomes and to allow reliable detection of significant group differences (or effective contrasts). In this work, regional PiB SUVRs were examined across 9 time windows to select the window that provided the best trade-offs between bias, correlation, and effective contrast. A total of 40 dynamic PiB PET studies were performed on controls (n = 16), patients with Alzheimer disease (AD; n = 11), and patients with mild cognitive impairment (MCI; n = 13) (555 MBq [15 mCi], 90-min scan, and arterial blood sampling). The SUVR was computed for five 20-min and four 30-min windows that spanned the 30- to 90-min postinjection period. The SUVRs were compared with Logan graphical distribution volume ratio (DVR) measurements (35-90 min), determined with arterial blood as input and without arterial blood as input (cerebellum as reference). Greater correlation and more bias were generally observed for the SUVR measurement at later times than at earlier times (relative to DVR). The effective contrast between the control and AD PiB SUVRs was slightly better for earlier data than for later data. The temporal dynamics of the SUVR measurement indicated greater stability in the measurement at 40 min after injection. The 50- to 70-min time window provided a good compromise between physiologic validity, stability, sensitivity, and clinical feasibility across the control, MCI, and AD subject data examined in this study. The 40- to 60-min period demonstrated

  18. Consideration of Optimal Time Window for Pittsburgh Compound B PET Summed Uptake Measurements

    PubMed Central

    McNamee, Rebecca L.; Yee, Seong-Hwan; Price, Julie C.; Klunk, William E.; Rosario, Bedda; Weissfeld, Lisa; Ziolko, Scott; Berginc, Michael; Lopresti, Brian; DeKosky, Steven; Mathis, Chester A.

    2009-01-01

    The standardized uptake value ratio (SUVR, or summed tissue ratio) has been used effectively in Pittsburgh compound B (PiB) PET studies to distinguish subjects who have significant amyloid-β deposition in their brain from those who do not. Relative to quantitative measurements, advantages of the SUVR are improved study feasibility and low test–retest variation; disadvantages include inherent bias (PiB retention overestimation) and potential for time-varying outcomes. The PiB SUVR has proven to be highly correlated with quantitative outcomes and to allow reliable detection of significant group differences (or effective contrasts). In this work, regional PiB SUVRs were examined across 9 time windows to select the window that provided the best trade-offs between bias, correlation, and effective contrast. Methods A total of 40 dynamic PiB PET studies were performed on controls (n =16), patients with Alzheimer disease (AD; n =11), and patients with mild cognitive impairment (MCI; n = 13) (555 MBq [15 mCi], 90-min scan, and arterial blood sampling). The SUVR was computed for five 20-min and four 30-min windows that spanned the 30- to 90-min postinjection period. The SUVRs were compared with Logan graphical distribution volume ratio (DVR) measurements (35–90 min), determined with arterial blood as input and without arterial blood as input (cerebellum as reference). Results Greater correlation and more bias were generally observed for the SUVR measurement at later times than at earlier times (relative to DVR). The effective contrast between the control and AD PiB SUVRs was slightly better for earlier data than for later data. The temporal dynamics of the SUVR measurement indicated greater stability in the measurement at 40 min after injection. Conclusion The 50- to 70-min time window provided a good compromise between physiologic validity, stability, sensitivity, and clinical feasibility across the control, MCI, and AD subject data examined in this study. The 40- to

  19. Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis.

    PubMed

    Lopresti, Brian J; Klunk, William E; Mathis, Chester A; Hoge, Jessica A; Ziolko, Scott K; Lu, Xueling; Meltzer, Carolyn C; Schimmel, Kurt; Tsopelas, Nicholas D; DeKosky, Steven T; Price, Julie C

    2005-12-01

    PET studies have been performed using the amyloid binding radiotracer Pittsburgh Compound B (PIB). Previous quantitative analyses using arterial blood showed that the Logan graphical analysis using 90 min of emission data (ART90) provided a reliable measure of PIB retention. This work reports on simplified methods of analysis for human PIB imaging. PIB PET scans were conducted in 24 subjects (6 Alzheimer's disease [AD], 10 mild cognitive impairment [MCI], 8 controls) with arterial blood sampling. Retest scans were performed on 8 subjects (3 AD, 1 MCI, 4 controls) within 28 d. Data were analyzed over 60 and 90 min using the Logan analysis and (a) metabolite-corrected input functions based on arterial plasma (ART60, ART90), (b) carotid artery time-activity data with a population average metabolite correction (CAR60, CAR90); and (c) cerebellar reference tissue (CER60, CER90). Data also were analyzed using the simplified reference tissue method (SRTM60, SRTM90) and a single-scan method based on late-scan ratios of standardized uptake values (SUVR60, SUVR90). All methods of analysis examined effectively discerned regional differences between AD and control subjects in amyloid-laden cortical regions, although the performance of the simplified methods varied in terms of bias, test-retest variability, intersubject variability, and effect size. CAR90 best agreed with ART90 distribution volume ratio (DVR) measures across brain regions and subject groups and demonstrated satisfactory test-retest variability (+/-7.1% across regions). CER90 and CER60 showed negative biases relative to ART90 in high-DVR subjects but had the lowest test-retest variability. The single-scan SUV-based methods showed the largest effect sizes for AD and control group differences and performed well in terms of intersubject and test-retest variability. Of the simplified methods for PIB analysis examined, CAR90 provided DVR measures that were most comparable to ART90; CER90 was the most reproducible and

  20. Presence of Panulirus argus virus 1 (PaV1) in juvenile spiny lobsters Panulirus argus from the Caribbean coast of Mexico.

    PubMed

    Huchin-Mian, Juan Pablo; Rodríguez-Canul, Rossanna; Arias-Bañuelos, Efrain; Simá-Alvarez, Raúl; Pérez-Vega, Juan A; Briones-Fourzán, Patricia; Lozano-Alvarez, Enrique

    2008-04-01

    Macroscopic evidence, histological sections, transmission electron microscopy (TEM) evaluation, and PCR analyses of 25 apparently diseased juvenile spiny lobsters Panulirus argus from the reef lagoon of Puerto Morelos, Mexico, showed the presence of Panulirus argus Virus 1 (PaV1). Cowdry Type A intranuclear viral inclusions were observed in histological analyses, icosahedral viral particles were observed by TEM, and PCR using specific primers for PaV1 amplified a fragment of 499 bp. This is the first report of PaV1 infecting P. argus outside the Florida Keys, USA.

  1. Ambient fine particulate concentrations and chemical composition at two sampling sites in metropolitan Pittsburgh: a 2001 intensive summer study

    NASA Astrophysics Data System (ADS)

    Modey, William K.; Eatough, Delbert J.; Anderson, Richard R.; Martello, Donald V.; Takahama, Satoshi; Lucas, Leonard J.; Davidson, Cliff I.

    The concentration and chemical composition of ambient fine particulate material (PM 2.5) is reported for two sampling sites in the Pittsburgh, Pennsylvania metropolitan area: the Department of Energy, National Energy Technology Laboratory (NETL) PM study site south of the city center, and the Carnegie Mellon Pittsburgh Air Quality Study (PAQS) site 5 km east of central Pittsburgh established with funding by the EPA Supersites Program and by DOE-NETL. Data from these sampling sites were characterized by one to three-day episodes with PM 2.5 concentrations (constructed from the sum of the chemical components) exceeding 40.0 μg m -3. The episodes were dominated by high concentrations of ammonium sulfate. The fine particle concentrations were compared with meteorological data from surface weather maps and a Hybrid Single Particle Lagrangian Integrated Trajectory model (HYSPLIT model), with back-trajectories estimated over 24 h. High PM 2.5 concentrations were associated with transition from a high pressure to a low pressure regime in advance of an approaching frontal system indicating long-range transport of pollutants. In contrast, fine particulate organic material appeared to be dominated by nearby sources. Distinct differences were observed in the diurnal variations in concentration between the two sites. The NETL site showed clear maximum concentrations of semi-volatile organic material (SVOM) during midday, and minimum concentrations of nonvolatile organic compounds in the afternoon. In contrast, the Carnegie Mellon PAQS site showed an absence of diurnal variation in SVOM, but still with minimum concentrations of nonvolatile organic compounds in the afternoon and evening. Neither site showed significant diurnal variation in ammonium sulfate.

  2. Sensor kinase PA4398 modulates swarming motility and biofilm formation in Pseudomonas aeruginosa PA14.

    PubMed

    Strehmel, Janine; Neidig, Anke; Nusser, Michael; Geffers, Robert; Brenner-Weiss, Gerald; Overhage, Joerg

    2015-02-01

    Pseudomonas aeruginosa is an opportunistic human pathogen that is able to sense and adapt to numerous environmental stimuli by the use of transcriptional regulators, including two-component regulatory systems. In this study, we demonstrate that the sensor kinase PA4398 is involved in the regulation of swarming motility and biofilm formation in P. aeruginosa PA14. APA4398 mutant strain was considerably impaired in swarming motility, while biofilm formation was increased by approximately 2-fold. The PA4398 mutant showed no changes in growth rate, rhamnolipid synthesis, or the production of the Pel exopolysaccharide but exhibited levels of the intracellular second messenger cyclic dimeric GMP (c-di-GMP) 50% higher than those in wild-type cells. The role of PA4398 in gene regulation was investigated by comparing the PA4398 mutant to the wildtype strain by using microarray analysis, which demonstrated that 64 genes were up- or downregulated more than 1.5-fold (P<0.05) under swarming conditions. In addition, more-sensitive real-time PCR studies were performed on genes known to be involved in c-di-GMP metabolism. Among the dysregulated genes were several involved in the synthesis and degradation of c-di-GMP or in the biosynthesis, transport, or function of the iron-scavenging siderophores pyoverdine and pyochelin, in agreement with the swarming phenotype observed. By analyzing additional mutants of selected pyoverdine- and pyochelin-related genes,we were able to show that not only pvdQ but also pvdR, fptA, pchA, pchD, and pchH are essential for the normal swarming behavior of P. aeruginosa PA14 and may also contribute to the swarming-deficient phenotype of the PA4398 mutant in addition to elevated c-di-GMP levels.

  3. The USA PATRIOT Act.

    ERIC Educational Resources Information Center

    Minow, Mary; Coyle, Karen; Kaufman, Paula

    2002-01-01

    Explains the USA PATRIOT (Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism) Act, passed after the September 11 terrorist attacks, and its implications for libraries and patron records. Considers past dealings with the FBI; court orders; search warrants; wiretaps; and subpoenas. Includes:…

  4. The USA PATRIOT Act.

    ERIC Educational Resources Information Center

    Minow, Mary; Coyle, Karen; Kaufman, Paula

    2002-01-01

    Explains the USA PATRIOT (Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism) Act, passed after the September 11 terrorist attacks, and its implications for libraries and patron records. Considers past dealings with the FBI; court orders; search warrants; wiretaps; and subpoenas. Includes:…

  5. Simplified Space Conditioning in Low-Load Homes: Results from Pittsburgh, Pennsylvania, New Construction Unoccupied Test House

    SciTech Connect

    Poerschke, A.; Stecher, D.

    2014-06-01

    Field testing was performed in a new construction unoccupied test house in Pittsburgh, Pennsylvania. Four air-based heating, ventilation, and air conditioning distribution systems--a typical airflow ducted system to the bedrooms, a low airflow ducted system to the bedrooms, a system with transfer fans to the bedrooms, and a system with no ductwork to the bedrooms--were evaluated during heating, cooling, and midseason conditions. The relative ability of each system was assessed with respect to relevant Air Conditioning Contractors of America and ASHRAE standards for house temperature uniformity and stability, respectively.

  6. Final report on EURAMET.M.P-S12 — Bilateral supplementary comparison of the national pressure standards of CMI and INRIM in the range 300 Pa to 15 kPa of negative gauge pressure

    NASA Astrophysics Data System (ADS)

    Krajícek, Zdenek; Bergoglio, Mercede; Pražák, Dominik; Pasqualin, Stefano

    2014-01-01

    This report describes a EURAMET bilateral supplementary comparison between Czech CMI and Italian INRIM in low negative gauge pressure in gas (nitrogen), denoted as EURAMET.M.P-S12. The digital non-rotating pressure balance FPG8601 manufactured by Fluke/DH-Instruments, USA is normally used for gauge and absolute pressures in the range from 1 Pa to 15 kPa, but with some modifications it can be used also for the negative gauge pressures in the same range. During the preparation of the visit of INRIM at CMI for the last comparison within the framework of EURAMET.M.P-K4.2010, it was agreed to also perform an additional comparison in the range from 300 Pa to 15 kPa of negative gauge pressure. The measurements were performed in October 2012. Both institutes successfully proved their equivalence in all the tested points in the range from 300 Pa to 15 kPa of negative gauge pressure in a comparison that had, so far, been unique. . Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  7. Amyloid Imaging With Carbon 11–Labeled Pittsburgh Compound B for Traumatic Brain Injury

    PubMed Central

    Hong, Young T.; Veenith, Tonny; Dewar, Deborah; Outtrim, Joanne G.; Mani, Vaithianadan; Williams, Claire; Pimlott, Sally; Hutchinson, Peter J. A.; Tavares, Adriana; Canales, Roberto; Mathis, Chester A.; Klunk, William E.; Aigbirhio, Franklin I.; Coles, Jonathan P.; Baron, Jean-Claude; Pickard, John D.; Fryer, Tim D.; Stewart, William; Menon, David K.

    2014-01-01

    OBJECTIVES To image amyloid deposition in patients with traumatic brain injury (TBI) using carbon 11–labeled Pittsburgh Compound B ([11C]PiB) positron emission tomography (PET) and to validate these findings using tritium-labeled PiB ([3H]PiB) autoradiography and immunocytochemistry in autopsy-acquired tissue. DESIGN, SETTING, AND PARTICIPANTS In vivo PET at tertiary neuroscience referral center and ex vivo immunocytochemistry of autopsy-acquired brain tissue from a neuropathology archive. [11C]PiB PET was used to image amyloid deposition in 11 controls (median [range] age, 35 [24–60] years) and in 15 patients (median [range] age, 33 [21–50] years) between 1 and 361 days after a TBI. [3H]PiB autoradiography and immunocytochemistry for β-amyloid (Aβ) and β-amyloid precursor protein in brain tissue were obtained from separate cohorts of 16 patients (median [range] age, 46 [21–70] years) who died between 3 hours and 56 days after a TBI and 7 controls (median [range] age, 61 [29–71] years) who died of other causes. MAIN OUTCOMES AND MEASURES We quantified the [11C]PiB distribution volume ratio and standardized uptake value ratio in PET images. The distribution volume ratio and the standardized uptake value ratio were measured in cortical gray matter, white matter, and multiple cortical and white matter regions of interest, as well as in striatal and thalamic regions of interest. We examined [3H]PiB binding and Aβ and β-amyloid precursor protein immunocytochemistry in autopsy-acquired brain tissue. RESULTS Compared with the controls, the patients with TBI showed significantly increased [11C]PiB distribution volume ratios in cortical gray matter and the striatum (corrected P < .05 for both), but not in the thalamus or white matter. Increases in [11C]PiB distribution volume ratios in patients with TBI were seen across most cortical subregions, were replicated using comparisons of standardized uptake value ratios, and could not be accounted for by

  8. Apparatus to measure the vapor pressure of slowly decomposing compounds from 1 Pa to 105 Pa

    PubMed Central

    Berg, Robert F.

    2016-01-01

    This article describes an apparatus and method for measuring vapor pressures in the range from 1 Pa to 105 Pa. Its three distinctive elements are : (1) the static pressure measurements were made with only a small temperature difference between the vapor and the condensed phase, (2) the sample was degassed in situ, and (3) the temperature range extended up to 200 °C. The apparatus was designed to measure metal-organic precursors, which often are toxic, pyrophoric, or unstable. Vapor pressures are presented for naphthalene, ferrocene, diethyl phthalate, and TEMAH (tetrakisethylmethylaminohafnium). Also presented are data for the temperature-dependent decomposition rate of TEMAH. PMID:27274567

  9. Experimental particle physics at the University of Pittsburgh. Progress report, 1 November 1993--31 October 1994

    SciTech Connect

    Engels, E. Jr.; Shepard, P.F.; Thompson, J.A.

    1994-05-01

    Task A involves the study of kaon decays. The overall physics focus of the current work is rare and semi-rare decays of the {phi} and the short-lived kaon, with an emphasis on those aspects needed in preparation for the proposed {Phi}-factory measurements of CPT violation. Another aspect of the rare kaon decay work is E865 at BNL, a search for K{sup +} yields {pi}{sup +}{mu}{sup +}e{sup {minus}}, a lepton number violating process. Pittsburgh`s E865 responsibilities are the design and construction of the Cerenkov counters. The major goals of task B are as follows: (1) the analysis of the E706 (direct photon production) data taken during the 1987--1988 and 1990--1991 target runs at Fermilab and (2) the continuation of work within SVXII group of the CDF collaboration. The CDF program involves a dedicated effort towards the design of the silicon vertex detector upgrade, SVXII.

  10. 18. Pennsylvania Railroad: Brick Arch Viaduct. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. Pennsylvania Railroad: Brick Arch Viaduct. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 87.44. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  11. 4. COBBS CREEK BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. COBBS CREEK BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, MP 5.73 - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  12. 28. Poquessing Creek Bridge. Philadelphia, Philadelphia Co., PA. Sec. 1101, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. Poquessing Creek Bridge. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 74.20. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  13. 5. ISLAND ROAD BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. ISLAND ROAD BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, MP 5.58. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  14. 21. Schuylkill River Bridge. Philadelphia, Philadelphia Co., PA. Sec. 1101, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. Schuylkill River Bridge. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 87.14. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  15. 19. Pennsylvania Railroad: Brick Arch Viaduct. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. Pennsylvania Railroad: Brick Arch Viaduct. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 87.44. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  16. 6. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. Sec. 1101, MP 3.11. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  17. 7. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. Sec. 1101, MP 3.11. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  18. 22. Schuylkill River Bridge. Philadelphia, Philadelphia Co., PA. Sec. 1101, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. Schuylkill River Bridge. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 87.14. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  19. 23. North Philadelphia Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. North Philadelphia Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 84.55. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  20. 27. Pennypack Creek Bridge. Philadelphia, Philadelphia Co., PA. Sec. 1101, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    27. Pennypack Creek Bridge. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 76.70. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  1. 20. Zoo Substation. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. Zoo Substation. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 87.25. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  2. 94. FONTHILL (19081912), SOUTH ELEVATION. SAME VIEW AS PA10764. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    94. FONTHILL (1908-1912), SOUTH ELEVATION. SAME VIEW AS PA-107-64. - Moravian Pottery & Tile Works, Southwest side of State Route 313 (Swamp Road), Northwest of East Court Street, Doylestown, Bucks County, PA

  3. Chicago, Illinois, USA

    NASA Technical Reports Server (NTRS)

    1990-01-01

    In this late winter scene of Chicago, Illinois, USA (42.0N, 87.5W) the light dusting of snow has actually enhanced the determination of the cities street pattern, parks and other cultural features. Sited at the south end of Lake Michigan, Chicago has long served as an industrial, transportation and communications center for the midwest. The obvious snowline on the ground enables meteorologists to trace the regional groundtracks of winter storms.

  4. Chicago, Illinois, USA

    NASA Technical Reports Server (NTRS)

    1990-01-01

    In this late winter scene of Chicago, Illinois, USA (41.5N, 87.0W) the light dusting of snow has actually enhanced the determination of the cities street pattern, parks and other cultural features. Sited at the south end of Lake Michigan, Chicago has long served as an industrial, transportation and communications center for the midwest. The obvious snowline on the ground enables meteorologists to trace the regional groundtracks of winter storms.

  5. Chicago, Illinois, USA

    NASA Image and Video Library

    1990-03-04

    In this late winter scene of Chicago, Illinois, USA (41.5N, 87.0W) the light dusting of snow has actually enhanced the determination of the cities street pattern, parks and other cultural features. Sited at the south end of Lake Michigan, Chicago has long served as an industrial, transportation and communications center for the midwest. The obvious snowline on the ground enables meteorologists to trace the regional groundtracks of winter storms.

  6. PaDe - The particle detection program

    NASA Astrophysics Data System (ADS)

    Ott, T.; Drolshagen, E.; Koschny, D.; Poppe, B.

    2016-01-01

    This paper introduces the Particle Detection program PaDe. Its aim is to analyze dust particles in the coma of the Jupiter-family comet 67P/Churyumov-Gerasimenko which were recorded by the two OSIRIS (Optical, Spectroscopic, and Infrared Remote Imaging System) cameras onboard the ESA spacecraft Rosetta, see e.g. Keller et al. (2007). In addition to working with the Rosetta data, the code was modified to work with images from meteors. It was tested with data recorded by the ICCs (Intensified CCD Cameras) of the CILBO-System (Canary Island Long-Baseline Observatory) on the Canary Islands; compare Koschny et al. (2013). This paper presents a new method for the position determination of the observed meteors. The PaDe program was written in Python 3.4. Its original intent is to find the trails of dust particles in space from the OSIRIS images. For that it determines the positions where the trail starts and ends. They were found using a fit following the so-called error function (Andrews, 1998) for the two edges of the profiles. The positions where the intensities fall to the half maximum were found to be the beginning and end of the particle. In the case of meteors, this method can be applied to find the leading edge of the meteor. The proposed method has the potential to increase the accuracy of the position determination of meteors dramatically. Other than the standard method of finding the photometric center, our method is not influenced by any trails or wakes behind the meteor. This paper presents first results of this ongoing work.

  7. Legionellaceae in the hospital water-supply. Epidemiological link with disease and evaluation of a method for control of nosocomial legionnaires' disease and Pittsburgh pneumonia.

    PubMed

    Best, M; Yu, V L; Stout, J; Goetz, A; Muder, R R; Taylor, F

    1983-08-06

    An epidemiological link was found between contamination of a hospital water-supply by Legionella pneumophila and by Pittsburgh pneumonia agent (PPA) and subsequent cases of nosocomial legionnaires' disease and Pittsburgh pneumonia. The extent of L pneumophila isolation from the water-supply paralleled the occurrence of disease. Whenever L pneumophila was isolated from more than 30% of ten selected water sites, nosocomial legionellosis occurred. The temperature of the hot water tanks was raised to 60-77 degrees C for 72 h, and water outlets were flushed for 30 min with hot water. A decline in numbers of L pneumophila and PPA in the water-supply was followed by a fall in the incidence of legionnaires' disease and Pittsburgh pneumonia. In addition, intermittent raising of the temperature in the hot water system decreased both the number of months in which disease occurred and the proportion of nosocomial pneumonias caused by these organisms.

  8. 76 FR 59503 - Establishment of Class E Airspace; Lebanon, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ... TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Lebanon, PA... Class E airspace at Lebanon, PA, to accommodate new Standard Instrument Approach Procedures that have... proposed rulemaking to amend Class E airspace 700 feet above the surface, at Lebanon, PA (76 FR 39038...

  9. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... personnel who work with privacy records/information. A PA self-assessment evaluation form is provided at... 32 National Defense 5 2011-07-01 2011-07-01 false PA self assessments/inspections. 701.124 Section... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.124 PA self assessments...

  10. American Uveitis Society Meeting October 30, 1995 Marriott Marquis Hotel, Atlanta, GA, USA.

    PubMed

    Meisler, D M; Chern, K C

    1996-01-01

    1 Retinal vascular occlusion and scleroderma. Tessler H, Flores-Guevara J, Goldstein D, Chicago, IL, USA. 2 MHC Class II antigen expression in ciliary body in spontaneous and experimental uveitis. Kalsow C, Zhavoronkova M, Dwyer A, Rochester, NY & Scottsville, NY, USA. 3 IL-10 in the vitreous of patients with intraocular lymphoma. Whitcup S, Solomon D, Nussenblatt R, Chan C-C, Bethesda, MD, USA 4 Iris juvenile xanthogranuloma studied by immunohistochemistry. Shields J, Shields C, Eagle R, DePotter P, Collins M, Philadelphia, PA, USA. 5 Outcomes analysis in with JRA-associated uveitis. Dana M-R, Merayo-Lloves J, Foster C, Boston MA, USA. 6 Persistent glaucoma secondary to periocular steroids. Akduman L, Conway M, Burchfield J, Kolker A, Black D, DelPriore L, Kaplan H, St. Louis, MO, USA 7 The use of itraconazole in ocular histoplasmosis Callanan D, Fish G, Dallas, TX, USA 8 Succesful treatment of macular hole secondary to sympathetic ophthalmia. Cano J, Diaz M, Navea A, Ruiz C, Castilla M. Barcelona, Spain. 9 HLA-DR2+ intermediate uveitis. Pulido J, Tang W, Han D, Mieler W. Milwaukee, WI, USA. 10 Vein occlusion in AIDS misdiagnosed as CMV retinitis. Park K, Marx J, Rao N. Los Angeles, CA, USA. 11 HIV-associated foveal hemorrhage. Crews K, Zimmerman P, Lohner S. Salt Lake City, UT, USA. 12 Cytomegalovirus papillitis in patients with AIDS. Patel S, Rutzen A, Marx J, Thach A, Chong L, Rao N, Los Angeles, CA, USA. 13 Recurrence rate of CMV retinitis following the ganciclovir implant and pars plans vitrectomy and silicone oil. Marx J, Thach A, Rao N, Chong L. Los Angeles, CA, USA.

  11. Parrot Bornavirus (PaBV)-2 isolate causes different disease patterns in cockatiels than PaBV-4.

    PubMed

    Piepenbring, Anne K; Enderlein, Dirk; Herzog, Sibylle; Al-Ibadi, Basim; Heffels-Redmann, Ursula; Heckmann, Julia; Lange-Herbst, Hildburg; Herden, Christiane; Lierz, Michael

    2016-01-01

    Psittaciform 1 bornavirus (PaBV) has already been shown to be the aetiologic agent of proventricular dilatation disease, a significant disease of birds. However, the pathogenesis of PaBV infection has not yet been resolved and valid data regarding the pathogenicity of different PaBV species are lacking. Thus, the present study was aimed to characterize the influence of two different PaBV species on the course of disease. Eighteen cockatiels were inoculated intracerebrally (i.c.) or intravenously (i.v.) with a PaBV-2 isolate under the same conditions as in a previous study using PaBV-4. Birds were surveyed and sampled for 33 weeks to analyse the course of infection and disease in comparison to that of PaBV-4. Similar to PaBV-4, PaBV-2 induced a persistent infection with seroconversion (from day 6 p.i. onwards) and shedding of viral RNA (from day 27 p.i. onwards). However, in contrast to PaBV-4, more birds displayed clinical signs and disease progression was more severe. After PaBV-2 infection, 12 birds exhibited clinical signs and 10 birds revealed a dilated proventriculus in necropsy. After PaBV-4 infection only four birds revealed clinical signs and seven birds showed a dilatation of the proventriculus. Clinically, different courses of disease were observed after PaBV-2 infection, mainly affecting the gastrointestinal tract. This had not been detected after PaBV-4 infection where more neurological signs were noted. The results provide evidence for different disease patterns according to different PaBV species, allowing the comparison between the infection with two PaBV species, and thus underlining the role of viral and individual host factors for disease outcome.

  12. 32 CFR 701.120 - Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...” exemption under the PA, delete any information about other persons and explain in the response letter that “information not about you” was deleted from the response. There is no PA exemption to claim and no appeal... in anticipation of litigation, the entire file is considered releasable under the PA. However, if the...

  13. 32 CFR 701.120 - Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...” exemption under the PA, delete any information about other persons and explain in the response letter that “information not about you” was deleted from the response. There is no PA exemption to claim and no appeal... in anticipation of litigation, the entire file is considered releasable under the PA. However, if the...

  14. 32 CFR 701.120 - Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...” exemption under the PA, delete any information about other persons and explain in the response letter that “information not about you” was deleted from the response. There is no PA exemption to claim and no appeal... in anticipation of litigation, the entire file is considered releasable under the PA. However, if the...

  15. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke.

    PubMed

    Saver, Jeffrey L; Goyal, Mayank; Bonafe, Alain; Diener, Hans-Christoph; Levy, Elad I; Pereira, Vitor M; Albers, Gregory W; Cognard, Christophe; Cohen, David J; Hacke, Werner; Jansen, Olav; Jovin, Tudor G; Mattle, Heinrich P; Nogueira, Raul G; Siddiqui, Adnan H; Yavagal, Dileep R; Baxter, Blaise W; Devlin, Thomas G; Lopes, Demetrius K; Reddy, Vivek K; du Mesnil de Rochemont, Richard; Singer, Oliver C; Jahan, Reza

    2015-06-11

    Among patients with acute ischemic stroke due to occlusions in the proximal anterior intracranial circulation, less than 40% regain functional independence when treated with intravenous tissue plasminogen activator (t-PA) alone. Thrombectomy with the use of a stent retriever, in addition to intravenous t-PA, increases reperfusion rates and may improve long-term functional outcome. We randomly assigned eligible patients with stroke who were receiving or had received intravenous t-PA to continue with t-PA alone (control group) or to undergo endovascular thrombectomy with the use of a stent retriever within 6 hours after symptom onset (intervention group). Patients had confirmed occlusions in the proximal anterior intracranial circulation and an absence of large ischemic-core lesions. The primary outcome was the severity of global disability at 90 days, as assessed by means of the modified Rankin scale (with scores ranging from 0 [no symptoms] to 6 [death]). The study was stopped early because of efficacy. At 39 centers, 196 patients underwent randomization (98 patients in each group). In the intervention group, the median time from qualifying imaging to groin puncture was 57 minutes, and the rate of substantial reperfusion at the end of the procedure was 88%. Thrombectomy with the stent retriever plus intravenous t-PA reduced disability at 90 days over the entire range of scores on the modified Rankin scale (P<0.001). The rate of functional independence (modified Rankin scale score, 0 to 2) was higher in the intervention group than in the control group (60% vs. 35%, P<0.001). There were no significant between-group differences in 90-day mortality (9% vs. 12%, P=0.50) or symptomatic intracranial hemorrhage (0% vs. 3%, P=0.12). In patients receiving intravenous t-PA for acute ischemic stroke due to occlusions in the proximal anterior intracranial circulation, thrombectomy with a stent retriever within 6 hours after onset improved functional outcomes at 90 days. (Funded

  16. uPA deficiency exacerbates muscular dystrophy in MDX mice

    PubMed Central

    Suelves, Mònica; Vidal, Berta; Serrano, Antonio L.; Tjwa, Marc; Roma, Josep; López-Alemany, Roser; Luttun, Aernout; de Lagrán, María Martínez; Díaz, Maria Àngels; Jardí, Mercè; Roig, Manuel; Dierssen, Mara; Dewerchin, Mieke; Carmeliet, Peter; Muñoz-Cánoves, Pura

    2007-01-01

    Duchenne muscular dystrophy (DMD) is a fatal and incurable muscle degenerative disorder. We identify a function of the protease urokinase plasminogen activator (uPA) in mdx mice, a mouse model of DMD. The expression of uPA is induced in mdx dystrophic muscle, and the genetic loss of uPA in mdx mice exacerbated muscle dystrophy and reduced muscular function. Bone marrow (BM) transplantation experiments revealed a critical function for BM-derived uPA in mdx muscle repair via three mechanisms: (1) by promoting the infiltration of BM-derived inflammatory cells; (2) by preventing the excessive deposition of fibrin; and (3) by promoting myoblast migration. Interestingly, genetic loss of the uPA receptor in mdx mice did not exacerbate muscular dystrophy in mdx mice, suggesting that uPA exerts its effects independently of its receptor. These findings underscore the importance of uPA in muscular dystrophy. PMID:17785520

  17. Historical carbon footprinting and implications for sustainability planning: a case study of the Pittsburgh region.

    PubMed

    Hoesly, Rachel; Blackhurst, Mike; Matthews, H Scott; Miller, Jeffrey F; Maples, Amy; Pettit, Matthew; Izard, Catherine; Fischbeck, Paul

    2012-04-17

    This study estimates fossil-based CO(2) emissions and energy use from 1900-2000 for Allegheny County, PA. Total energy use and emissions increased from 1900 to 1970, reflecting the significant industrial, economic, and population growth that occurred in Allegheny County. From 1970 to 2000, Allegheny County experienced a 30% decrease in total emissions and energy use from peak values, primarily because of a decline in industrial activity (40% decrease in value added) and the loss of a quarter of its population. Despite these dramatic economic and demographic transitions, per capita emissions remained stable from 1970 to 2000, buoyed by relatively stable or slightly increasing emissions in the commercial and transportation sectors. Allegheny County's history suggests the scale of change needed to achieve local emissions reductions may be significant; given years of major technological, economic, and demographic changes, per capita emissions in 1940 were nearly the same in 2000. Most local governments are planning emissions reductions rates that exceed 1% per year, which deviate significantly from historical trends. Our results suggest additional resources and improved planning paradigms are likely necessary to achieve significant emissions reductions, especially for areas where emissions are still increasing.

  18. Global update: USA.

    PubMed

    Matthews, Kirstin R W

    2011-11-01

    The NIH, which has an annual budget of over US$31 billion, is the world's largest biomedical research agency and is a major strength for science in the USA. Despite the political nature of stem cell research, this area of science has flourished across the country. In 2010, the NIH funded approximately US$1.3 billion in stem cell research. According to the ISI Web of Science, more than 4000 US-authored stem cell publications were produced in 2010 - approximately 40% of the world total. The average citation rate was 4.12 per article, with six articles amassing 100 citations in less than 18 months after release.

  19. “Food is directed to the area”: African Americans’ perceptions of the neighborhood nutrition environment in Pittsburgh

    PubMed Central

    Quinn, Sandra C.; Kriska, Andrea M.; Thomas, Stephen B.

    2011-01-01

    Studies have shown racial disparities in neighborhood access to healthy food in the United States. We used a mixed methods approach employing geographic information systems, focus groups, and a survey to examine African Americans’ perceptions of the neighborhood nutrition environment in Pittsburgh. We found that African Americans perceive that supermarkets serving their community offer produce and meats of poorer quality than branches of the same supermarket serving White neighborhoods (p<0.001). Unofficial taxis or jitneys, on which many African Americans are reliant, provide access from only certain stores; people are therefore forced to patronize these stores even though they are perceived to be of poorer quality. Community-generated ideas to tackle the situation include ongoing monitoring of supermarkets serving the Black community. We conclude that stores should make every effort to be responsive to the perceptions and needs of their clients and provide an environment that enables healthy eating. PMID:21169050

  20. Distribution, prevalence, and genetic analysis of Panulirus argus virus 1 (PaV1) from the Caribbean Sea.

    PubMed

    Moss, Jessica; Behringer, Donald; Shields, Jeffrey D; Baeza, Antonio; Aguilar-Perera, Alfonso; Bush, Phillippe G; Dromer, Clement; Herrera-Moreno, Alejandro; Gittens, Lester; Matthews, Thomas R; McCord, Michael R; Schärer, Michelle T; Reynal, Lionel; Truelove, Nathanial; Butler, Mark J

    2013-05-27

    The pathogenic virus Panulirus argus virus 1 (PaV1) was first discovered in Caribbean spiny lobsters Panulirus argus from the Florida Keys (USA) in 1999 and has since been reported in Belize, Mexico, and Cuba; its distribution in the wider Caribbean is unknown. We collected tissue samples from adult spiny lobsters from 30 locations in 14 countries bordering the Caribbean Sea and used molecular diagnostics to assay for the presence of PaV1. PaV1 occurred primarily in the northern areas of the Caribbean, where its prevalence was highest. The virus was not found in lobsters from the southeastern Caribbean, and its prevalence was lowest in the southwestern Caribbean. DNA sequence analysis was performed on a fragment of the viral DNA to examine the genetic diversity of PaV1 on a Caribbean-wide scale. Sequence variation in the viral DNA fragment was high, with 61 unique alleles identified from 9 areas. The sharing of viral alleles in lobsters from distant locations supports the hypothesis of a strong genetic connectivity among lobsters within the Caribbean, and further supports the hypothesis that postlarvae infected with PaV1 may serve to disperse the virus over long distances.

  1. Findings from the Pittsburgh Youth Study: cognitive impulsivity and intelligence as predictors of the age-crime curve.

    PubMed

    Loeber, Rolf; Menting, Barbara; Lynam, Donald R; Moffitt, Terri E; Stouthamer-Loeber, Magda; Stallings, Rebecca; Farrington, David P; Pardini, Dustin

    2012-11-01

    This article first summarizes key research findings from the Pittsburgh Youth Study from 1987 to the present, and focuses on delinquency in 1,517 young men who have been followed up from late childhood into their 20s. Second, the article addresses how indicators of self-control prospectively predict later offending, and whether the prediction shows individual difference in the age-crime curve, particularly the up-slope, peak, and down-slope of that curve. Longitudinal analyses were conducted on a sample of boys in the middle sample of the Pittsburgh Youth Study (n = 422), whose cognitive impulsivity and intelligence were assessed at about age 12 years. Criminal records on the sample were until age 28. The results show that cognitive impulsivity and intelligence, measured between ages 12 and 13 by means of psychometric tests, predicted the age-crime curve. The age-arrest curve was substantially higher in boys with high cognitive impulsivity and in boys with low IQ. However, there was a significant interaction between cognitive impulsivity and intelligence. For boys with high IQ, cognitive impulsivity was associated with a greater escalation in the prevalence of offending during early adolescence, followed by a more rapid decline in offending as boys entered early adulthood with a slight subsequent increase in criminal offending then occurring late 20. In contrast, there was no evidence that cognitive impulsivity independently influenced criminal offending at any developmental period for boys with low IQ. The results are discussed in terms of interventions to reduce individuals' delinquency from childhood through early adulthood and lower the age-crime curve for populations. However, the association was complex because it was moderated by both age and intelligence. Copyright © 2012. Published by Elsevier Inc.

  2. Te mahi niho hauora ki Ratana Pa: the dental health project at Ratana Pa.

    PubMed

    Broughton, J

    1995-09-01

    Following the success of a dental health project provided for Maori communities along the Wanganui River by the Royal New Zealand Dental Corps, the people of Ratana Pa, 20 km south of Wanganui, requested a similar service. Funding for a pilot project was provided by the Central Regional Health Authority through Good Health Wanganui. The project was a joint venture between the Health Committee of Ratana Pa and Dental Health of Good Health Wanganui. The dental health of the people at Ratana Pa was generally poor, featuring a high rate of decay and serious periodontal disease. Severe halitosis was common. As a result of poor oral health, many patients, especially young women, were whakama, a state of embarrassment and shame that caused them to keep their teeth hidden. An increase in self-esteem and greater interest in dental health occurred after treatment. A second treatment phase began in March 1995. This community-driven Maori health initiative, in partnership with a Regional Health Authority, fulfils obligations under the Treaty of Waitangi.

  3. New Jersey, USA

    NASA Image and Video Library

    1982-03-30

    STS003-10-606 (30 March 1982) --- The entire state of New Jersey (39.5N, 74.5W) is seen in great detail in this photograph. Philadelphia, PA on the west bank of the Delaware River and Camden, NJ on the east bank of this natural boundary, are easily seen as well as the coastal resort of Atlantic City. Further north, New York City and most of Long Island can be seen in fair detail while further inland, the northern Appalachian Mountains can be seen going diagonal across the scene. Photo credit: NASA

  4. Art, Science & Visual Literacy: Selected Readings from the Annual Conference of the International Visual Literacy Association (24th, Pittsburgh, Pennsylvania, September 30-October 4, 1992).

    ERIC Educational Resources Information Center

    Braden, Roberts A., Ed.; And Others

    Following an introductory paper on Pittsburgh and the arts, 57 conference papers are presented under the following four major categories: (1) "Imagery, Science and the Arts," including discovery in art and science, technology and art, visual design of newspapers, multimedia science education, science learning and interactive videodisc technology,…

  5. Art, Science & Visual Literacy: Selected Readings from the Annual Conference of the International Visual Literacy Association (24th, Pittsburgh, Pennsylvania, September 30-October 4, 1992).

    ERIC Educational Resources Information Center

    Braden, Roberts A., Ed.; And Others

    Following an introductory paper on Pittsburgh and the arts, 57 conference papers are presented under the following four major categories: (1) "Imagery, Science and the Arts," including discovery in art and science, technology and art, visual design of newspapers, multimedia science education, science learning and interactive videodisc technology,…

  6. Education for Highway Engineering and Highway Transport. Report of the Regional Conference Held at University of Pittsburgh, Friday, November 26, 1920. Bulletin, 1921, No. 47

    ERIC Educational Resources Information Center

    Johnson, Pyke; John, Walton C.

    1921-01-01

    This bulletin provides information on the proceedings of the regional conference on education for highway engineering and highway transport that was held at the University of Pittsburgh on November 26, 1920, under the direction of the highway and highway transport education committee. The purpose of this report is: (1) To stimulate greater…

  7. EVALUATION OF THE CMB AND PMF MODELS USING ORGANIC MOLECULAR MARKERS IN FINE PARTICULATE MATTER COLLECTED DURING THE PITTSBURGH AIR QUALITY STUDY

    EPA Science Inventory

    This research investigated different strategies for source apportionment of airborne fine particulate matter (PM2.5) collected as part of the Pittsburgh Air Quality Study. Two source receptor models were used, the EPA Chemical Mass Balance 8.2 (CMB) and EPA Positive Matrix Facto...

  8. EVALUATION OF THE CMB AND PMF MODELS USING ORGANIC MOLECULAR MARKERS IN FINE PARTICULATE MATTER COLLECTED DURING THE PITTSBURGH AIR QUALITY STUDY

    EPA Science Inventory

    This research investigated different strategies for source apportionment of airborne fine particulate matter (PM2.5) collected as part of the Pittsburgh Air Quality Study. Two source receptor models were used, the EPA Chemical Mass Balance 8.2 (CMB) and EPA Positive Matrix Facto...

  9. Focusing on Achievement in the Pittsburgh Public Schools: Report of the Strategic Support Team of the Council of the Great City Schools

    ERIC Educational Resources Information Center

    Council of the Great City Schools, 2007

    2007-01-01

    The Pittsburgh Public School district is one of many urban school systems across the country that is struggling to boost student performance and regain the respect of its community. Achievement gaps are wide; student achievement is low; and public confidence is fragile. To begin addressing these issues, the Council of the Great City Schools…

  10. Evaluating the national air toxics assessment (NATA): Comparison of predicted and measured air toxics concentrations, risks, and sources in Pittsburgh, Pennsylvania

    NASA Astrophysics Data System (ADS)

    Logue, Jennifer M.; Small, Mitchell J.; Robinson, Allen L.

    2011-01-01

    The National Air Toxics Assessment (NATA) is an ongoing modeling effort by the Environmental Protection Agency to predict air toxics concentrations, sources, and risks at the census tract level throughout the continental United States. To evaluate NATA, archived data collected at seven sites in and around Pittsburgh, Pennsylvania were compared to 2002 NATA predictions. The sites represent 3 different source regimes (mobile dominated, industrial point source dominated, and background). The evaluation considered 49 air toxics (37 gas-phase organics, 10 metals, coke oven emissions and diesel particulate matter); NATA's performance was judged based on model-measurement comparisons of concentrations, health risks, and source contributions. On a concentration basis, NATA performance varied widely ranging from excellent for carbon tetrachloride to differences of more than a factor of 100 for low concentration chlorinated compounds. However, predicted concentrations were generally within a factor of 2 of measured values for air toxics that were estimated to be the primary cancer risk drivers; therefore NATA provided reasonable estimates of the additive cancer risks and risk ranking of air toxics. NATA performs better on average in Pittsburgh than nationwide. Comparison of source apportionment results indicates that NATA consistently underestimated concentrations of compounds emitted by large point sources as well as concentrations of chlorinated compounds, but overestimated the risks from mobile sources in Pittsburgh. Therefore, in Pittsburgh, NATA sufficiently prioritizes air toxics that drive potential cancer risks, but does not identify the sources of these priority air toxics.

  11. Detroit, Michigan, USA

    NASA Image and Video Library

    2017-09-27

    Detroit, Michigan, USA Sensor: L7 ETM+ Acquisition Date: December 11, 2001 Path/Row: 20/30 Lat/Long: 42.330/-83.046 Detroit, Michigan, is commonly referred to as Motor City because of the many automobile manufacturing plants located in the city. It is the largest city in Michigan, with a population approaching one million. Credit: NASA/Goddard/Landsat NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

  12. Proteasome Activators, PA28α and PA28β, Govern Development of Microvascular Injury in Diabetic Nephropathy and Retinopathy

    PubMed Central

    Mahmoudpour, Ali

    2016-01-01

    Diabetic nephropathy (DN) and diabetic retinopathy (DR) are major complications of type 1 and type 2 diabetes. DN and DR are mainly caused by injury to the perivascular supporting cells, the mesangial cells within the glomerulus, and the pericytes in the retina. The genes and molecular mechanisms predisposing retinal and glomerular pericytes to diabetic injury are poorly characterized. In this study, the genetic deletion of proteasome activator genes, PA28α and PA28β genes, protected the diabetic mice in the experimental STZ-induced diabetes model against renal injury and retinal microvascular injury and prolonged their survival compared with wild type STZ diabetic mice. The improved wellbeing and reduced renal damage was associated with diminished expression of Osteopontin (OPN) and Monocyte Chemoattractant Protein-1 (MCP-1) in the glomeruli of STZ-injected PA28α/PA28β double knockout (Pa28αβDKO) mice and also in cultured mesangial cells and retinal pericytes isolated from Pa28αβDKO mice that were grown in high glucose. The mesangial PA28-mediated expression of OPN under high glucose conditions was suppressed by peptides capable of inhibiting the binding of PA28 to the 20S proteasome. Collectively, our findings demonstrate that diabetic hyperglycemia promotes PA28-mediated alteration of proteasome activity in vulnerable perivascular cells resulting in microvascular injury and development of DN and DR. PMID:27830089

  13. Deconvolution and Quantification of Primary and Oxygenated Organic Aerosols: Technique Development and Applications to the Pittsburgh AMS Datasets

    NASA Astrophysics Data System (ADS)

    Zhang, Q.; Jimenez, J.; Alfarra, R.; Allan, J.; Coe, H.; Worsnop, D.; Canagaratna, M.

    2004-12-01

    A new technique has been developed to deconvolve and quantify the mass concentrations of primary and oxygenated organic aerosol (POA and OOA) using highly time-resolved organic mass spectral data obtained with an Aerodyne Aerosol Mass Spectrometer (AMS). OOA may comprise secondary organic aerosol (SOA) as well as oxidized POA. This technique involves a series of multivariate linear regressions that use mass-to-charge ratios (m/z's) 57 (mostly C4H9+) and 44 (mostly CO2+), the identified AMS mass spectral tracers for POA and OOA, respectively, as the initial principal components followed by an iterative algorithm to evaluate and "purify" POA and OOA mass spectral tracers. We have applied this technique to the AMS organic aerosol data acquired at the EPA Pittsburgh Supersite during September 2002 and have observed excellent agreement between the reconstructed organic concentrations (= POA + OOA) and the measured values (r2 = 0.997, slope = 0.998). The reconstructed organic data matrix (size = 3199 time steps x 300 m/z's) explains 99% of the variance in the measured time series. The extracted mass spectrum of POA shows high similarity to those of diesel exhaust sampled during a chase study, lab-measured lubricating oil, and freshly emitted traffic aerosols measured in urban environments. The spectrum of OOA closely resembles those of aged organic aerosols sampled in remote areas and also shows similarity with the spectrum of fulvic acid-a humic-like substance that is ubiquitous in the environment and has previously been used as an analogue to represent polyacid compounds found in highly processed and oxidized atmospheric organic aerosols. Organic aerosols in Pittsburgh during Sept. 2002 are mainly oxygenated, on average consisting of ~ 70% OOA (likely mainly secondary in nature). Pronounced diurnal variations in the POA/OOA contributions to organic mass have been observed, with the contribution of POA peaking in the morning rush hours while that of OOA is largest in

  14. ETV REPORT - PHYSICAL REMOVAL OF CRYPTOSPORIDIUM OOCYSTS AND GIARDIA CYSTS IN DRINKING WATER AQUASOURCE NORTH AMERICA ULTRAFILTRATION SYSTEM A35 AT PITTSBURGH, PA. - NSF00/07/EPADW395

    EPA Science Inventory

    Verification testing of the Aquasource Ultrafiltration Treatment System Model A35 was conducted from 12/1 - 12/31/98. The treatment system underwent microbial challenge testing on 1/22/99 and demonstrated a 5.5 log10 removal of Giardia cysts and a 6.5 log10 removal of Cryptospori...

  15. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT PHYSICAL REMOVAL OF CRYPTOSPORIDIUM OOCYSTS AND GIARDIA CYSTS IN DRINKING WATER PALL CORPORATION WPM-1 MICROFILTRATION SYSTEM AT PITTSBURGH, PA - NSF 00/09/EPADW395

    EPA Science Inventory

    Verification testing of the Pall Corporation WPM-1 Microfiltration Pilot System was conducted from February 3 to March 5, 1999. The Pall WPM-1 membrane is a hollow fiber type microfiltration membrane made of polyvinylidenefluoride (PVDF). It has a 0.1 micrometer ( m) nominal por...

  16. Genome Sequence of Pseudomonas chlororaphis Strain PA23

    PubMed Central

    Loewen, Peter C.; Villenueva, Jacylyn; Fernando, W. G. Dilantha

    2014-01-01

    Pseudomonas chlororaphis strain PA23 is a plant-beneficial bacterium that is able to suppress disease caused by the fungal pathogen Sclerotinia sclerotiorum through a process known as biological control. Here we present a 7.1-Mb assembly of the PA23 genome. PMID:25035328

  17. Evaluation of ID-PaGIA syphilis antibody test.

    PubMed

    Naaber, Paul; Makoid, Ene; Aus, Anneli; Loivukene, Krista; Poder, Airi

    2009-01-01

    Laboratory diagnosis of syphilis is usually accomplished by serology. There are currently a large number of different commercial treponemal tests available that vary in format, sensitivity and specificity. To evaluate the ID-PaGIA Syphilis Antibody Test as an alternative to other specific treponemal tests for primary screening or confirmation of diagnosis. Serum samples from healthy adults (n = 100) were used for detection of specificity of ID-PaGIA. To evaluate sensitivity of ID-PaGIA serum samples (n = 101) from patients with confirmed or suspected syphilis were tested for syphilis antibodies with FTA-Abs IgM, ID-PaGIA, ELISA IgM and TPHA tests. No false-positive results were found with ID-PaGIA. Sensitivity of various treponemal tests was the following: FTA-Abs IgM: 95.5%, ID-PaGIA and ELISA IgM: 94%, and TPHA 75%. The positive and negative predictive values of ID-PaGIA were 100 and 89.5%, respectively. Compared with other treponemal tests ID-PaGIA has excellent sensitivity and specificity.

  18. 32 CFR 701.109 - Privacy Act (PA) appeals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 5 2014-07-01 2014-07-01 false Privacy Act (PA) appeals. 701.109 Section 701.109 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.109 Privacy Act (PA) appeals....

  19. 32 CFR 701.109 - Privacy Act (PA) appeals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 5 2013-07-01 2013-07-01 false Privacy Act (PA) appeals. 701.109 Section 701.109 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.109 Privacy Act (PA) appeals....

  20. Map of the Johnson Company's works, Johnstown, PA. Scale 1 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Map of the Johnson Company's works, Johnstown, PA. Scale 1 inch - 50 ft, July 16, 1983. Revised to June 28, 1897, company drawing no. 13080. (photograph of drawing held at the Johnstown Corporation General Office, Johnstown, Pennsylvania) - Johnson Steel Street Rail Company, 525 Central Avenue, Johnstown, Cambria County, PA

  1. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false PA self assessments/inspections. 701.124 Section 701.124 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.124 PA self assessments...

  2. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 5 2013-07-01 2013-07-01 false PA self assessments/inspections. 701.124 Section 701.124 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.124 PA self assessments...

  3. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false PA self assessments/inspections. 701.124 Section 701.124 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.124 PA self assessments...

  4. 33 CFR 110.67 - Delaware River, Essington, Pa.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Delaware River, Essington, Pa. 110.67 Section 110.67 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.67 Delaware River, Essington, Pa. North of...

  5. 33 CFR 110.67 - Delaware River, Essington, Pa.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Delaware River, Essington, Pa. 110.67 Section 110.67 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.67 Delaware River, Essington, Pa. North of...

  6. 33 CFR 110.67 - Delaware River, Essington, Pa.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Delaware River, Essington, Pa. 110.67 Section 110.67 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.67 Delaware River, Essington, Pa. North of...

  7. 33 CFR 110.67 - Delaware River, Essington, Pa.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Delaware River, Essington, Pa. 110.67 Section 110.67 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.67 Delaware River, Essington, Pa. North of...

  8. 32 CFR 701.109 - Privacy Act (PA) appeals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false Privacy Act (PA) appeals. 701.109 Section 701.109 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.109 Privacy Act (PA) appeals. (a...

  9. 32 CFR 701.109 - Privacy Act (PA) appeals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false Privacy Act (PA) appeals. 701.109 Section 701.109 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.109 Privacy Act (PA) appeals. (a...

  10. 78 FR 26243 - Amendment of Class E Airspace; Easton, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Easton, PA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E Airspace at... Federal Register a notice of proposed rulemaking (NPRM) to amend Class E airspace at Easton, PA (78...

  11. 78 FR 48297 - Amendment of Class E Airspace; Bedford, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Bedford, PA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E Airspace at... proposed rulemaking (NPRM) to amend Class E airspace at Bedford County Airport, Bedford, PA. (78 FR...

  12. Observations of 231Pa/ 235U disequilibrium in volcanic rocks

    NASA Astrophysics Data System (ADS)

    Pickett, David A.; Murrell, Michael T.

    1997-04-01

    We present here the first survey of ( 231Pa/ 235U) ratios in volcanic rocks; such measurements are made possible by new mass spectrometric techniques. The data place new constraints on the timing and extent of magma source and evolutionary processes, particularly due to the sensitivity of the 231Pa- 235U pair and its intermediate time scale ( 231Pat 1/2 = 33 ky). ( 231Pa/ 235U) is found to vary widely, from 0.2 in carbonatites to 1.1-2.9 in basalts and 0.9-2.2 in arcs. Substantial Pa enrichment is nearly ubiquitous, suggestive of the relative incompatibility of Pa, qualitatively consistent with available partitioning data. The level of 231Pa- 235U disequilibrium typically far exceeds that of 230Th- 238U and is comparable to 226Ra- 230Th. The high ( 231Pa/ 235U) ratios in MORB and other basalts reflect a large degree of discrimination between two incompatible elements, posing challenges for modelling of melt generation and migration. Fundamental differences in ( 231Pa/ 235U) among different basaltic environments are likely related to contrasts in melting zone conditions (e.g., melting rate). Strong ( 231Pa/ 235U) disequilibria in continental basalts, for which ( 230Th/ 238U) disequilibria are small or absent, demonstrate that Pa-U fractionation is possible in both garnet and spinel mantle stability fields. In arcs, correlation of ( 231Pa/ 235U) and ( 230Th/ 238U) is consistent with U enrichment via slab-derived fluids, a process which is additional to the still dominant Pa enrichment. An important new constraint is provided by the observation that the near-equilibrium ( 230Th/ 238U) common to arcs and continental basalts is not typically accompanied by near-equilibrium ( 231Pa/ 235U), arguing against the influence of long magma history, crustal material, or equilibrium mantle sources in affecting decay-series ratios. Small sample sets from two silicic centers illustrate: (1) recent, rapid U enrichment in the magma chamber (El Chichón); and (2) the failure of

  13. Elucidating Protactinium Hydrolysis: The Relative Stabilities of PaO2(H2O)(+) and PaO(OH)2(+).

    PubMed

    Dau, Phuong D; Wilson, Richard E; Gibson, John K

    2015-08-03

    It is demonstrated that the gas-phase oxo-exchange of PaO2(+) with water is substantially faster than that of UO2(+), indicating that the Pa-O bonds are more susceptible to activation and formation of the bis-hydroxide intermediate, PaO(OH)2(+). To elucidate the nature of the water adduct of PaO2(+), hydration of PaO2(+) and UO2(+), as well as collision induced dissociation (CID) and ligand-exchange of the water adducts of PaO2(+) and UO2(+), was studied. The results indicate that, in contrast to UO2(H2O)(+), the protactinium oxo bis-hydroxide isomer, PaO(OH)2(+), is produced as a gas-phase species close in energy to the hydrate isomer, PaO2(H2O)(+). CID behavior similar to that of Th(OH)3(+) supports the assignment as PaO(OH)2(+). The gas-phase results are consistent with the spontaneous hydrolysis of PaO2(+) in aqueous solution, this in contrast to later AnO2(+) (An = U, Np, Pu), which forms stable hydrates in both solution and gas phase. In view of the known propensity for Th(IV) to hydrolyze, and previous gas-phase studies of other AnO2(+), it is concluded that the stabilities of oxo-hydroxides relative to oxide hydrates decreases in the order: Th(IV) > Pa(V) > U(V) > Np(V) > Pu(V). This trend suggests increasing covalency and decreasing ionicity of An-O bonds upon proceeding across the actinide series.

  14. Dengue in Florida (USA)

    PubMed Central

    Rey, Jorge R.

    2014-01-01

    Florida (USA), particularly the southern portion of the State, is in a precarious situation concerning arboviral diseases. The geographic location, climate, lifestyle, and the volume of travel and commerce are all conducive to arbovirus transmission. During the last decades, imported dengue cases have been regularly recorded in Florida, and the recent re-emergence of dengue as a major public health concern in the Americas has been accompanied by a steady increase in the number of imported cases. In 2009, there were 28 cases of locally transmitted dengue in Key West, and in 2010, 65 cases were reported. Local transmission was also reported in Martin County in 2013 (29 cases), and isolated locally transmitted cases were also reported from other counties in the last five years. Dengue control and prevention in the future will require close cooperation between mosquito control and public health agencies, citizens, community and government agencies, and medical professionals to reduce populations of the vectors and to condition citizens and visitors to take personal protection measures that minimize bites by infected mosquitoes. PMID:26462955

  15. PA014-- Deception and Doubt --Strategies for Undermining and Supporting Global Climate Science--PA014

    NASA Astrophysics Data System (ADS)

    Nelson, C.

    2012-12-01

    DECEPTION AND DOUBT--STRATEGIES FOR UNDERMINING AND SUPPORTING GLOBAL CLIMATE SCIENCE--PA014 The fundamental strategy for undermining confidence in the now substantial scientific consensus about global warming is to sow doubt about the degree of consensus. Rather than mount an obvious anti-science stance, commercial interests seek to champion science, arguing for better science, more complete and definitive science. This strategy has a sixty-year history, beginning with the tobacco industry in the 1950s and proceeding through the chemical, energy, paint, and other industries. Thousands of faculty members have quietly sold themselves as public spokespersons or confidential consultants to industry in the service of this strategy. A multipart program--involving educating people about this history and exposing faculty collaboration--may help free climate science from those who aim to distort its conclusions.

  16. Association of Socioeconomic Status with Mortality in Type 1 Diabetes: The Pittsburgh Epidemiology of Diabetes Complications (EDC) Study

    PubMed Central

    Secrest, Aaron M; Costacou, Tina; Gutelius, Bruce; Miller, Rachel G; Songer, Thomas J; Orchard, Trevor J

    2011-01-01

    Purpose Socioeconomic status (SES) as a risk factor for mortality in type 1 diabetes (T1D) has not been adequately studied prospectively Methods Complete clinical and SES (income, education, occupation) data were available for 317 T1D participants in the Pittsburgh Epidemiology of Diabetes Complications Study within 4 years of age 28 (chosen to maximize income, education, and occupational potential, and to minimize the SES effect of advanced diabetes complications). Vital status was determined as of 1/1/2008. Results Over a median 16 years of follow-up, 34 (10.7%) deaths occurred (SMR=4.1, 95% CI, 2.7–5.5). SMRs did not differ from the general population for those in the highest education and income groups, whereas in those with low SES, SMRs were increased. Mortality rates were 3 times lower for individuals with versus without a college degree (p=0.004) and nearly 4 times lower for the highest versus lower income groups (p=0.04). In Cox models adjusting for diabetes duration and sex, education was the only SES measure predictive of mortality (HR=3.0, 1.2–7.8), but lost significance after adjusting for HbA1c, non-HDL cholesterol, hypertension, and microalbuminuria (HR=2.1, 0.8–5.6). Conclusions The strong association of education with mortality in T1D is partially mediated by better glycemic, lipid and blood pressure control. PMID:21458730

  17. Reliability and validity of the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale in older men.

    PubMed

    Spira, Adam P; Beaudreau, Sherry A; Stone, Katie L; Kezirian, Eric J; Lui, Li-Yung; Redline, Susan; Ancoli-Israel, Sonia; Ensrud, Kristine; Stewart, Anita

    2012-04-01

    The Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS) are commonly used to quantify sleep and excessive daytime sleepiness in older adults. These measures, however, have not been comprehensively evaluated for their psychometrics in older men. We determined the internal consistency reliability and construct validity of the PSQI and ESS in a sample of older men. Participants were 3,059 men (mean age = 76.4 years) in the Osteoporotic Fractures in Men Study (MrOS) who completed the two questionnaires, wrist actigraphy, and a range of additional psychosocial and health measures. Internal consistency was adequate for the PSQI (Cronbach's α =.69) and the ESS (α = .70) total scores. PSQI daytime dysfunction and sleep medications components were weakly associated with the total score, but their removal did not notably improve internal consistency. PSQI and ESS totals were associated with each other and with theoretically related variables (ie, actigraphic variables, depressive symptoms, mobility/instrumental activities of daily living, health-related quality of life) in expected directions. The PSQI differentiated participants reporting no sleep disorder from those reporting particular disorders more reliably than the ESS. In general, we found evidence of the internal consistency reliability and construct validity of the PSQI and ESS in older men. Despite low correlation with the PSQI global score, the PSQI daytime dysfunction and sleep medications components do not appreciably reduce the PSQI total score's reliability or validity in older men.

  18. Structural and construct validity of the Czech version of the Pittsburgh Sleep Quality Index in chronic insomnia.

    PubMed

    Dudysová, Daniela; Malá, Ivana; Mladá, Karolína; Saifutdinova, Elizaveta; Koprivova, Jana; Sos, Peter

    2017-02-01

    The Pittsburgh Sleep Quality Index (PSQI) is one of the widely used and recommended measures of assessing sleep quality in chronic insomnia; however certain psychometric properties of the questionnaire are still unknown in this group of patients. The present study aimed to examine the internal consistency, and structural and convergent validity of the Czech version of the PSQI in chronic insomnia patients. The usefulness of the standard and alternative scoring systems was also investigated in relation to symptoms of sleepiness, insomnia, depression, and anxiety. In our study, 105 participants filled out a series of questionnaires including PSQI, Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), and Beck Depression and Anxiety Inventories (BDI, BAI). The internal consistency of the questionnaire using Cronbach's alpha was 0.608. A series of confirmatory factor analyses revealed adequate fit for three structures. A three-factor model descriptively stood out among the rest but subsequent correlational analyses did not provide sufficient support for accepting an alternative scoring model. The results highlight the issue of structural variance of the PSQI and in chronic insomnia point to the important role of the PSQI components of daytime dysfunction and sleep disturbances in showing comorbid symptoms with daytime sleepiness and psychopathology.

  19. A study of parabens and bisphenol A in surface water and fish brain tissue from the Greater Pittsburgh Area.

    PubMed

    Renz, Lara; Volz, Conrad; Michanowicz, Drew; Ferrar, Kyle; Christian, Charles; Lenzner, Diana; El-Hefnawy, Talal

    2013-05-01

    Pollution from xenoestrogens has been discovered in the aquatic environment of the Greater Pittsburgh Area and is suspected to be caused by the failing sewer system. Personal care products and plasticizers have the potential to enter the water supply though treated and untreated sewage. Many of these compounds are suspected xenoestrogens. Paraben detection in surface waters was as follows: methyl paraben ranged between 2.2 to 17.3 ppt; ethyl paraben was not detectable; propyl paraben was detected at 9.2 and 12.0 ppt; butyl paraben was detected at 0.2 ppt. BPA was detected between 0.6 and 15.4 ppt. Estrogenic potential of extracts from fish brain tissue was tested via Bromodeoxyuridine MCF-7 analysis and paired with HPLC-MS to investigate the presence of xenoestrogens. All samples were non-detectable for parabens. BPA was detected in 44 of the 58 samples, with a range from non-detectable to 120 pg/g. BCFs were calculated. Results were statistically significant for location of capture (p < 0.05) and correlation existed between estrogenicity and BPA.

  20. Sliding friction study of the oscillating translational motion for steel on PA66 and PA46 type materials

    NASA Astrophysics Data System (ADS)

    Lates, M. T.; Velicu, R. G.; Papuc, R.

    2016-08-01

    The paper presents the study of the friction, by using tests, in the sliding translational oscillating motion of the steel on PA46 relative to the steel on PA66 type materials by considering as variables the testing parameters as: the load, the velocity and the operating temperature. The paper starts with a study of the literature and, according to that, presents the main conclusions regarding the sliding friction of the steel on PA66 and PA46 type materials and identifies the lacks of the results. The tests are performed on an oscillating motion type tribometer module. First, it is made a running-in program, for each of the materials, at 25 and 90°C, a load of 5 N and a frequency of 1 Hz for one hour; after that, there are performed tests at 90°C and 120°C, at loads of 3 N, 5 N, 7 N and at frequencies at 0.25 Hz, 5 Hz and 1 Hz. The results are presented for the PA46 type material relative to the PA66 material. The conclusions indicate in which conditions and with which advantages are used the PA66 and PA46 polyamides in the case of oscillating translational motions.

  1. SFE/SFHTA/AFCE consensus on primary aldosteronism, part 1: Epidemiology of PA, who should be screened for sporadic PA?

    PubMed

    Baguet, Jean-Philippe; Steichen, Olivier; Mounier-Véhier, Claire; Gosse, Philippe

    2016-07-01

    Depending on the study, the prevalence of primary aldosteronism (PA) in patients with hypertension varies from 6 to 18%. Prevalence is higher in each of the following conditions, any one of which requires screening for PA: severe hypertension (systolic blood pressure [BP]≥180mmHg and/or diastolic BP≥110mmHg); resistant hypertension (systolic BP≥140mmHg and/or diastolic BP≥90mmHg despite adherence to a tritherapy including a thiazide diuretic); hypertension associated with hypokalemia (either spontaneous or associated with a diuretic); Hypertension or hypokalemia associated with adrenal incidentaloma. It should be borne in mind that PA can induce hypertension without hypokalemia or, less frequently, hypokalemia without hypertension. Finally, as cardiovascular and renal morbidity in PA is greater than in essential hypertension of equivalent level, screening for PA is indicated when cardiovascular or renal morbidity is more severe than predicted from BP level.

  2. Biogeography in 231Pa/230Th ratios and a balanced 231Pa budget for the Pacific Ocean

    NASA Astrophysics Data System (ADS)

    Hayes, Christopher T.; Anderson, Robert F.; Fleisher, Martin Q.; Serno, Sascha; Winckler, Gisela; Gersonde, Rainer

    2014-04-01

    The ratio of unsupported protactinium-231 to thorium-230 in marine sediments, (Pa/Th)xs, is potentially sensitive to several processes of oceanographic and climatological interest: deep ocean circulation, marine biological productivity (as it relates to total particle flux) and particle composition (specifically, biogenic opal and authigenic Mn). In order to attribute variations in (Pa/Th)xs observed in sediment records to changes in specific processes through time, a better understanding of the chemical cycling of these elements in the modern ocean is necessary. To this end, a survey was undertaken of (Pa/Th)xs in surface sediments from the subarctic Pacific (SO202-INOPEX expedition) in combination with a Pacific-wide compilation of published data. Throughout the Pacific, (Pa/Th)xs is robustly correlated with the opal content of sediments. In the North and equatorial Pacific, simultaneous positive correlations with productivity indicators suggest that boundary scavenging and opal scavenging combine to enhance the removal of Pa in the eastern equatorial Pacific and subarctic Pacific. Deep ocean water mass ageing (>3.5 km) associated with the Pacific overturning appears to play a secondary role in determining the basin scale distribution of (Pa/Th)xs. A basin-wide extrapolation of Pa removal is performed which suggests that the Pacific Pa budget is nearly in balance. We hypothesize that through time (Pa/Th)xs distributions in the Pacific could define the evolving boundaries of contrasting biogeographic provinces in the North Pacific, while the influence of hydrothermal scavenging of Pa potentially confounds this approach in the South Pacific.

  3. Cold response in Phalaenopsis aphrodite and characterization of PaCBF1 and PaICE1.

    PubMed

    Peng, Po-Hsin; Lin, Chia-Hui; Tsai, Hui-Wen; Lin, Tsai-Yun

    2014-09-01

    Phalaenopsis is a winter-blooming orchid genus commonly cultivated in tropical Asian countries. Because orchids are one of the most economically important flower crops in Taiwan, it is crucial to understand their response to cold and other abiotic stresses. The present study focused on gene regulation of P. aphrodite in response to abiotic stress, mainly cold. Our results demonstrate that P. aphrodite is sensitive to low temperatures, especially in its reproductive stage. We found that after exposure to 4°C, plants in the vegetative stage maintained better membrane integrity and photosynthetic capacity than in the flowering stage. At the molecular level, C-repeat binding factor1 (PaCBF1) and its putative target gene dehydrin1 (PaDHN1) mRNAs were induced by cold, whereas inducer of CBF expression1 (PaICE1) mRNA was constitutively expressed. PaICE1 transactivated MYC motifs in the PaCBF1 promoter, indicating that up-regulation of PaCBF1 may be mediated by the binding of PaICE1 to MYC motifs. Overexpression of PaCBF1 in transgenic Arabidopsis induced AtCOR6.6 and RD29a without cold stimulus and maintained better membrane integrity after cold stress. Herein, we present evidence that cold induction of PaCBF1 transcripts in P. aphrodite may be transactivated by PaICE1 and consequently protect plants from cold damage through up-regulation of cold-regulated (COR) genes, such as DHN. To our knowledge, this study is the first report of the isolation and characterization of CBF, DHN and ICE genes in the Orchidaceae family.

  4. Microfluidic manufacture of rt-PA-loaded echogenic liposomes

    PubMed Central

    Kandadai, Madhuvanthi A.; Mukherjee, Prithviraj; Shekhar, Himanshu; Shaw, George J.; Papautsky, Ian; Holland, Christy K.

    2016-01-01

    Echogenic liposomes (ELIP), loaded with recombinant tissue-type plasminogen activator (rt-PA) and microbubbles that act as cavitation nuclei, are under development for ultrasound-mediated thrombolysis. Conventional manufacturing techniques produce a polydisperse rt-PA-loaded ELIP population with only a small percentage of particles containing microbubbles. Further, a polydisperse population of rt-PA-loaded ELIP has a broadband frequency response with complex bubble dynamics when exposed to pulsed ultrasound. In this work, a microfluidic flow-focusing device was used to generate monodisperse rt-PA-loaded ELIP (µtELIP) loaded with a perfluorocarbon gas. The rt-PA associated with the µtELIP was encapsulated within the lipid shell as well as intercalated within the lipid shell. The µtELIP had a mean diameter of 5 µm, a resonance frequency of 2.2 MHz, and were found to be stable for at least 30 min in 0.5%bovine serum albumin. Additionally, 35 % of µtELIP particles were estimated to contain microbubbles, an order of magnitude higher than that reported previously for batch-produced rt-PA-loaded ELIP. These findings emphasize the advantages offered by microfluidic techniques for improving the encapsulation efficiency of both rt-PA and perflurocarbon microbubbles within echogenic liposomes. PMID:27206512

  5. The Online Bioinformatics Resources Collection at the University of Pittsburgh Health Sciences Library System—a one-stop gateway to online bioinformatics databases and software tools

    PubMed Central

    Chen, Yi-Bu; Chattopadhyay, Ansuman; Bergen, Phillip; Gadd, Cynthia; Tannery, Nancy

    2007-01-01

    To bridge the gap between the rising information needs of biological and medical researchers and the rapidly growing number of online bioinformatics resources, we have created the Online Bioinformatics Resources Collection (OBRC) at the Health Sciences Library System (HSLS) at the University of Pittsburgh. The OBRC, containing 1542 major online bioinformatics databases and software tools, was constructed using the HSLS content management system built on the Zope® Web application server. To enhance the output of search results, we further implemented the Vivísimo Clustering Engine®, which automatically organizes the search results into categories created dynamically based on the textual information of the retrieved records. As the largest online collection of its kind and the only one with advanced search results clustering, OBRC is aimed at becoming a one-stop guided information gateway to the major bioinformatics databases and software tools on the Web. OBRC is available at the University of Pittsburgh's HSLS Web site (). PMID:17108360

  6. Productivity improvement for longwall development

    SciTech Connect

    Whipkey, K.

    2005-08-01

    Industry survey reveals coal operators thoughts about the use of different techniques to keep development ahead of longwall production. Factors considered that can optimise productivity include mine design (the number of entries, size of pillars etc.), work schedules, preventative maintenance programs and good management. The article was adapted from a presentation to Longwall USA 2005, in June 2005 (Pittsburgh, PA, USA). 3 figs.

  7. FrogwatchUSA

    USGS Publications Warehouse

    Droege, S.

    2002-01-01

    full text: Frogs and toads are perhaps the most approachable and available of all our wildlife. In many, if not most places, they are abundant. In wetter parts of the East, almost anyone outside on a warm rainy night in spring will hear their dream-like calls, bellows, trills and snores. Even in the deserts of the Southwest, a nocturnal trip after a summer monsoon will yield toads moving across the roads toward a cacophonous orgy of mating and calling in the roadside ditches and desert pools. Birds share with frogs and toads this same sense of presence in our daily lives. But the difference is that birds are like the attractive neighbor who just never gives you the time of day, while frogs are more like the troglodyte who appears regularly to chat, philosophize, and have a beer. Uninvited, frogs appear in our water gardens, toads are on our stoops in the morning, we catch them when we are kids, raise their babies in the aquarium, and feel sorry when we find we have run them over with the lawnmower. When concerns about declining populations of amphibians reached the mass media, the Secretaries' office became involved. In addition to using traditional research mechanisms to investigate the problem, the Secretary also wanted to involve the public directly. The combination of high public appeal and the relative ease with which frog calls can be learned made a large-scale monitoring program for frogs and toads possible. What emerged was a program called Frogwatch USA, modeled after a successful Canadian program with a similar name. A web site was created (www.frogwatch.org) that presented potential frogwatchers with directions and a way to register their site online as well as enter their data. Observers chose where to count frogs depending on what they felt was important. For some it was their backyard, others chose vulnerable wetlands in their neighborhoods, or spots on local refuges and parks. Initially funded at $8,000 a year and then after two years increased to

  8. Apportionment of ambient primary and secondary pollutants during a 2001 summer study in Pittsburgh using U.S. Environmental Protection Agency UNMIX.

    PubMed

    Anderson, Richard R; Martello, Donald V; Lucas, Leonard J; Davidson, Cliff I; Modey, William K; Eatough, Delbert J

    2006-09-01

    Apportionment of primary and secondary pollutants during the summer 2001 Pittsburgh Air Quality Study (PAQS) is reported. Several sites were included in PAQS, with the main site (the supersite) adjacent to the Carnegie Mellon University campus in Schenley Park. One of the additional sampling sites was located at the National Energy Technology Laboratory, located approximately 18 km southeast of downtown Pittsburgh. Fine particulate matter (PM2.5) mass, gas-phase volatile organic material (VOM), particulate semivolatile and nonvolatile organic material (NVOM), and ammonium sulfate were apportioned at the two sites into their primary and secondary contributions using the U.S. Environmental Protection Agency UNMIX 2.3 multivariate receptor modeling and analysis software. A portion of each of these species was identified as originating from gasoline and diesel primary mobile sources. Some of the organic material was formed from local secondary transformation processes, whereas the great majority of the secondary sulfate was associated with regional transformation contributions. The results indicated that the diurnal patterns of secondary gas-phase VOM and particulate semivolatile and NVOM were not correlated with secondary ammonium sulfate contributions but were associated with separate formation pathways. These findings are consistent with the bulk of the secondary ammonium sulfate in the Pittsburgh area being the result of contributions from distant transport and, thus, decoupled from local activity involving organic pollutants in the metropolitan area.

  9. View south of hydraulic hammer in boilermakers shop (probably the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View south of hydraulic hammer in boilermakers shop (probably the oldest piece of equipment in the yard, originally powered by steam) nameplate: United Engineers and FDRY. Co. Pittsburgh, Pa, USA Davy Brothers LTD. Patents - Aug 1, 1905, Feb, 1901, Sept 8, 1908 - 10000 lbs. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Structure Shop, League Island, Philadelphia, Philadelphia County, PA

  10. Orion PA-1 Flight Test Crew Module Back at Dryden

    NASA Image and Video Library

    The boilerplate Orion crew module and separation ring that was flown in the Launch Abort system PA-1 flight test at White Sands Missile Range, N.M., May 6 were airlifted back to NASA Dryden at Edwa...

  11. RadNet Air Data From Bloomsburg, PA

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Bloomsburg, PA from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  12. RadNet Air Data From Philadelphia, PA

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Philadelphia, PA from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  13. 78 FR 7848 - Pennsylvania Disaster Number PA-00057

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00057 AGENCY: U.S. Small Business Administration. ACTION.... ADDRESSES: Submit completed loan applications to: U.S. Small Business Administration, Processing...

  14. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... SECNAVINST 5210.8D). These reports shall be made available to PA program officials and to CNO (DNS-36)/CMC... until the next self-assessment is completed. Make these reports available, upon request, to CNO (DNS-36...

  15. LePaProGen—lepton pair production generator

    NASA Astrophysics Data System (ADS)

    Dydyshka, Ya. V.; Yermolchyk, V. L.; Suarez, J. H.; Shumeiko, N. M.

    2017-09-01

    A Monte Carlo generator "LePaProGen" for simulation of lepton pair production at hadron colliders is presented. Higher order electroweak radiative effects are implemented. A new algorithm for selection of the optimal phase space parameterization is applied.

  16. Former Baldwin Hardware Corp. – Reading, PA PAD00235083

    EPA Pesticide Factsheets

    EPA is announcing its proposed decision that includes groundwater remediation, soil vapor capture and treatment as well as restrictions on land and groundwater uses under RCRA for the Baldwin Hardware Corporation facility in Reading PA, EPA ID PAD00235083

  17. 14. Photocopy of original drawing, Bethlehem Steel Company (Bethlehem, PA) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Photocopy of original drawing, Bethlehem Steel Company (Bethlehem, PA) 1928 (Source: Vermont Agency of Transportation) CENTER SECTION TRUSS DETAILS - Jeffersonville Bridge, Spanning Lamoille River on Vermont Route 15, Cambridge, Lamoille County, VT

  18. 15. Photocopy of original drawing, Bethlehem Steel Company (Bethlehem, PA) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Photocopy of original drawing, Bethlehem Steel Company (Bethlehem, PA) 1928 (Source: Vermont Agency of Transportation) DETAILS OF PORTALS AND TOP LATERALS - Jeffersonville Bridge, Spanning Lamoille River on Vermont Route 15, Cambridge, Lamoille County, VT

  19. 13. Photocopy of original drawing, Bethlehem Steel Company (Bethlehem, PA) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Photocopy of original drawing, Bethlehem Steel Company (Bethlehem, PA) 1928 (Source: Vermont Agency of Transportation) STEEL SUPERSTRUCTURE - Jeffersonville Bridge, Spanning Lamoille River on Vermont Route 15, Cambridge, Lamoille County, VT

  20. 16. Photocopy of original drawing, Bethlehem Steel Company (Bethlehem, PA) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Photocopy of original drawing, Bethlehem Steel Company (Bethlehem, PA) 1928 (Source: Vermont Agency of Transportation) END SECTION TRUSS DETAILS - Jeffersonville Bridge, Spanning Lamoille River on Vermont Route 15, Cambridge, Lamoille County, VT

  1. 12. Photocopy of original drawing, Bethlehem Steel Company (Bethlehem, PA) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Photocopy of original drawing, Bethlehem Steel Company (Bethlehem, PA) 1928 (Source: Vermont Agency of Transportation) PLAN AND PROFILE - Jeffersonville Bridge, Spanning Lamoille River on Vermont Route 15, Cambridge, Lamoille County, VT

  2. 76 FR 70528 - Pennsylvania Disaster Number PA-00044

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00044 AGENCY: U.S. Small Business Administration. ACTION... unchanged. (Catalog of Federal Domestic Assistance Numbers 59002 and 59008) James E. Rivera, Associate...

  3. 76 FR 70527 - Pennsylvania Disaster Number PA-00042

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00042 AGENCY: U.S. Small Business Administration. ACTION... unchanged. (Catalog of Federal Domestic Assistance Numbers 59002 and 59008) James E. Rivera Associate...

  4. 76 FR 72994 - Pennsylvania Disaster Number PA-00045

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00045 AGENCY: U.S. Small Business Administration. ACTION... Federal Domestic Assistance Numbers 59002 and 59008) James E. Rivera, Associate Administrator for Disaster...

  5. Construct validity and factor structure of the Pittsburgh Sleep Quality Index among pregnant women in a Pacific-Northwest cohort.

    PubMed

    Qiu, Chunfang; Gelaye, Bizu; Zhong, Qiu-Yue; Enquobahrie, Daniel A; Frederick, Ihunnaya O; Williams, Michelle A

    2016-03-01

    Poor sleep quality during pregnancy is associated with adverse obstetric and neuropsychiatric outcomes. Despite its routine use as a sleep quality assessment scale among men and non-pregnant women, the psychometric properties of the Pittsburgh Sleep Quality Index (PSQI) have not been assessed among US pregnant women. We sought to evaluate the construct validity and factor structure of the PSQI among 1488 pregnant women. A structured interview was used to collect information about demographics and sleep characteristics in early pregnancy. The Patient Health Questionnaire-9 (PHQ-9) and the Depression, Anxiety, and Stress Scale-21 (DASS-21) were used to assess symptoms of depression, anxiety, and stress. Consistency indices, exploratory and confirmatory factor analyses (EFA and CFA), correlations, and logistic regression procedures were used. The reliability coefficient, Cronbach's alpha for the PSQI items was 0.74. Results of the EFA showed that a rotated factor solution for the PSQI contained two factors with eigenvalues >1.0 accounting for 52.8 % of the variance. The PSQI was significantly positively correlated with the PHQ-9 (r s = 0.48) and DASS-21 (r s = 0.42) total scores. Poor sleepers (PSQI global score >5) had increased odds of experiencing depression (OR = 6.47; 95 % CI = 4.56-9.18), anxiety (OR = 3.59; 95 % CI = 2.45-5.26), and stress (OR = 4.37; 95 % CI = 2.88-6.65) demonstrating evidence of good construct validity. CFA results corroborated the two-factor structure finding from the EFA and yielded reassuring measures indicating goodness of fit (comparative fit index = 0.975) and accuracy (root mean square error of approximation = 0.035). The PSQI has good construct validity and reliability for assessing sleep quality among pregnant women.

  6. The Pittsburgh Sleep Quality Index in a multi-ethnic Asian population contains a three-factor structure.

    PubMed

    Koh, Hiromi W L; Lim, Raymond Boon Tar; Chia, Kee Seng; Lim, Wei Yen

    2015-12-01

    The Pittsburgh Sleep Quality Index (PSQI) is a widely used measure for assessing sleep impairment. Although it was developed as a unidimensional instrument, there is much debate that it contains multidimensional latent constructs. We examined the dimensionality of the underlying factor structure of PSQI in Singapore, a rapidly industrialising Asian country with multi-ethnicities representing the Chinese, Malays and Indians. The PSQI was administered through an interviewer-based questionnaire in two separate population-based cross-sectional surveys. An explanatory factor analysis (EFA) was first used to explore the underlying construct of the PSQI in both studies. Then, a confirmatory factor analysis (CFA) was conducted to evaluate an optimal factor model by comparing against other possible models identified in EFA. There are three correlated yet distinguishable factors that account for an individual's sleep experience from the same best-fit model obtained in both studies: perceived sleep quality, daily disturbances and sleep efficiency. Our three-factor structure of PSQI is superior to the originally intended unidimensional model. Our model also shows the best-fit indices when compared to the previously reported single-factor, two-factor and three-factor (by Cole et al.) models in a multi-ethnic Asian population. There is strong evidence that the PSQI contains a three-factor rather than a unidimensional structure in a multi-ethnic Asian population. Scoring the PSQI along their multidimensional perspectives may provide a more accurate understanding of the relationship between sleep impairment and health conditions rather than using a single global score.

  7. Associations between Socioeconomic Status and Major Complications in Type 1 Diabetes: The Pittsburgh Epidemiology of Diabetes Complication (EDC) Study

    PubMed Central

    Secrest, Aaron M.; Costacou, Tina; Gutelius, Bruce; Miller, Rachel G.; Songer, Thomas J.; Orchard, Trevor J.

    2011-01-01

    Purpose To understand the effect of socioeconomic status (SES) on the risk of complications in type 1 diabetes (T1D), we explored the relationship between SES and major diabetes complications in a prospective, observational T1D cohort study. Methods Complete data were available for 317 T1D persons within 4 years of age 28 (ages 24–32) in the Pittsburgh Epidemiology of Diabetes Complications Study. Age 28 was selected to maximize income, education, and occupation potential, and minimize the effect of advanced diabetes complications on SES. Results The incidences over 1–20 years follow-up of end-stage renal disease (ESRD) and coronary artery disease (CAD) were 2–3 times higher for T1D individuals without, compared to those with a college degree (p<0.05 for both), while autonomic neuropathy (AN) incidence was significantly higher for low income and/or non-professional participants (p<0.05 for both). HbA1c was inversely associated only with income level. In sex- and diabetes duration-adjusted Cox models, lower education predicted ESRD (HR=2.9, 95% CI, 1.1–7.7) and CAD (HR=2.5, 1.3–4.9), whereas lower income predicted AN (HR=1.7, 1.0–2.9) and lower extremity arterial disease (HR=3.7, 1.1–11.9). Conclusions These associations, partially mediated by clinical risk factors, suggest that lower SES T1D individuals may have poorer self-management and, thus, more diabetes complications. PMID:21458731

  8. Psychometric evaluation and feasibility of the Greek Pittsburgh Sleep Quality Index (GR-PSQI) in patients with cancer receiving chemotherapy.

    PubMed

    Kotronoulas, Grigorios C; Papadopoulou, Constantina N; Papapetrou, Anastasia; Patiraki, Elisabeth

    2011-11-01

    Quality of sleep in patients with cancer is regarded as of utmost importance. The aim of the present study was to assess psychometric properties and feasibility of the Greek version of the Pittsburgh Sleep Quality Index (GR-PSQI). Following a "forward-backward" procedure, the scale was translated into Greek. The GR-PSQI was administered as a self-report instrument to 209 consecutive patients with cancer during active-phase chemotherapy treatment. For stability analysis purposes, a subgroup of 60 patients completed the GR-PSQI on two occasions, 14-21 days apart. All participants also completed the Insomnia Severity Index, the Epworth Sleepiness Scale-Greek version, a Sleep Quality-Visual Analogue Scale and the Hospital Anxiety and Depression Scale-Greek version. Validity and reliability analyses were performed for GR-PSQI data. The Chronbach's alpha for the global GR-PSQI score was 0.76. Test-retest reliability analysis for the global GR-PSQI score yielded a high intra-class correlation coefficient of 0.82 (p < 0.001). Exploratory factor analysis generated a two-factor structure for the GR-PSQI, [quality of nocturnal sleep] and [daily disturbances and management of sleep problems]. This construct was further supported by its high correlations with similar content instruments, as well as by the instrument's ability to discriminate well between contrasting groups of patients with different levels of anxiety, depression and performance status. The present findings support the GR-PSQI as a reliable, stable over time and valid sleep quality instrument when administered to patients with cancer during chemotherapy treatment; however, it is suggested that the use of a two-factor scoring method (instead of the traditional unidimensional) could improve its sensitivity in this patient group.

  9. Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimer's disease with Pittsburgh Compound B.

    PubMed

    Raji, Cyrus A; Becker, James T; Tsopelas, Nicholas D; Price, Julie C; Mathis, Chester A; Saxton, Judith A; Lopresti, Brian J; Hoge, Jessica A; Ziolko, Scott K; DeKosky, Steven T; Klunk, William E

    2008-07-30

    We evaluated the region-to-region correlation, laterality and asymmetry of amyloid deposition in subjects with mild cognitive impairment (MCI) or Alzheimer's disease (AD) using the amyloid tracer, Pittsburgh Compound B (PiB). Seventeen subjects, including 7 with MCI (MMSE 26.7+/-2.4) and 10 with AD (MMSE of 24.8+/-2.7) underwent PiB imaging. Measures of laterality (i.e., group-wise predilection for right or left) and asymmetry (i.e., group-wise predilection for unequal PiB retention between the two hemispheres) were calculated for 17 Regions of Interest (ROIs). Regional correlations were calculated along with within-group and between-groups statistical analyses of laterality and asymmetry metrics. The median correlation between PiB retention across all pairs of ROIs was 0.65, with highest correlations found in areas of highest PiB retention (r=0.74). Overall, PiB retention was symmetric bilaterally, but there was PiB laterality in MCI in dorsal frontal cortex [(t(6)=3.05, p=0.02, L>R] and sensory-motor area [t(6)=3.10, p=0.02, L>R] and in AD in the occipital pole (t(9)=-2.63, p=0.03, R>L). The most significant asymmetries in PiB retention were found in sub-cortical white matter (t(6)=3.99, p=0.01) and middle precuneus [(t(6)=3.57, p=0.01] in MCI, and in lateral temporal cortex (t(9)=3.02, p=0.01) and anterior ventral striatum [t(9)=2.37, p=0.04] in AD. No group differences (AD versus MCI) were detected in laterality [F (1, 15)=0.15, p=0.7] or asymmetry [F (1, 15)=0.7, p=0.42].

  10. Exploration of dimensionality and psychometric properties of the Pittsburgh Sleep Quality Index in cases with temporomandibular disorders

    PubMed Central

    2014-01-01

    Background This study assessed the dimensional structure of sleep quality with the Pittsburgh Sleep Quality Index (PSQI) and investigated its psychometric properties in cases with temporomandibular disorders (TMD). Methods A convenience sample of 609 TMD cases (age: 37.1 ± 13.1 yrs, 18–67 yrs, 85% female) of the multi-center Validation Project meeting Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) and with sufficient PSQI data were included in this study. To investigate PSQI scores’ dimensionality, exploratory factor analysis was used. Factors were identified using the Scree plot. To investigate internal consistency, Cronbach’s alpha was calculated. Analyses were separately performed for TMD cases with (N = 496) and TMD cases withouta pain-related diagnosis (N = 113). Results The mean PSQI score for all TMD cases was 7.1 ± 4.0 units, range: 0–19. The exploratory factor analysis identified one factor for cases with at least one pain-related TMD diagnosis as well as one factor for cases with a pain-free TMD diagnosis that explained 41% of the variance in cases with pain-related TMD and 37% in cases with pain-free TMD. Internal consistency for PSQI scores was alpha of 0.75 in cases with pain-related TMD, alpha of 0.66 in cases with pain-free TMD and alpha = 0.75 for all TMD cases. Conclusions Sleep quality in TMD patients is a unidimensional construct and can therefore be represented by one summary score; a finding that is in line with previous reports in TMD patients. PMID:24443942

  11. The Pediocin PA-1 Accessory Protein Ensures Correct Disulfide Bond Formation in the Antimicrobial Peptide Pediocin PA-1.

    PubMed

    Oppegård, Camilla; Fimland, Gunnar; Anonsen, Jan Haug; Nissen-Meyer, Jon

    2015-05-19

    Peptides, in contrast to proteins, are generally not large enough to form stable and well-defined three-dimensional structures. However, peptides are still able to form correct disulfide bonds. Using pediocin-like bacteriocins, we have examined how this may be achieved. Some pediocin-like bacteriocins, such as pediocin PA-1 and sakacin P[N24C+44C], have four cysteines. There are three possible ways by which the four cysteines may combine to form two disulfide bonds, and the three variants are expected to be produced in approximately equal amounts if their formation is random. Pediocin PA-1 and sakacin P[N24C+44C] with correct disulfide bonds were the main products when they were secreted by the pediocin PA-1 ABC transporter and accessory protein, but when they were secreted by the corresponding secretion machinery for sakacin A, a pediocin-like bacteriocin with one disulfide bond (two cysteines), peptides with all three possible disulfide bonds were produced in approximately equal amounts. All five cysteines in the pediocin PA-1 ABC transporter and the two cysteines (that form a CxxC motif) in the accessory protein were individually replaced with serines to examine their involvement in disulfide bond formation in pediocin PA-1. The Cys86Ser mutation in the accessory protein caused a 2-fold decrease in the amount of pediocin PA-1 with correct disulfide bonds, while the Cys83Ser mutation nearly abolished the production of pediocin PA-1 and resulted in the production of all three disufide bond variants in equal amounts. The Cys19Ser mutation in the ABC transporter completely abolished secretion of pediocin PA-1, suggesting that Cys19 is in the proteolytic active site and involved in cleaving the prebacteriocin. Replacing the other four cysteines in the ABC transporter with serines caused a slight reduction in the overall amount of secreted pediocin PA-1, but the relative amount with the correct disulfide bonds remained large. These results indicate that the pediocin

  12. Detection of anthrax protective antigen (PA) using europium labeled anti-PA monoclonal antibody and time-resolved fluorescence ◊

    PubMed Central

    Stoddard, Robyn A.; Quinn, Conrad P.; Schiffer, Jarad M.; Boyer, Anne E.; Goldstein, Jason; Bagarozzi, Dennis A.; Soroka, Stephen D.; Dauphin, Leslie A.; Hoffmaster, Alex R.

    2015-01-01

    Inhalation anthrax is a rare but acute infectious disease following adsorption of Bacillus anthracis spores through the lungs. The disease has a high fatality rate if untreated, but early and correct diagnosis has a significant impact on case patient recovery. The early symptoms of inhalation anthrax are, however, non-specific and current anthrax diagnostics are primarily dependent upon culture and confirmatory real-time PCR. Consequently, there may be a significant delay in diagnosis and targeted treatment. Rapid, culture-independent diagnostic tests are therefore needed, particularly in the context of a large scale emergency response. The aim of this study was to evaluate the ability of monoclonal antibodies to detect anthrax toxin proteins that are secreted early in the course of B. anthracis infection using a time-resolved fluorescence (TRF) immunoassay. We selected monoclonal antibodies that could detect protective antigen (PA), as PA83 and also PA63 and LF in the lethal toxin complex. The assay reliable detection limit (RDL) was 6.63 × 10−6 μM (0.551 ng/ml) for PA83 and 2.51 × 10−5 μM (1.58 ng/ml) for PA63. Despite variable precision and accuracy of the assay, PA was detected in 9 out of 10 sera samples from anthrax confirmed case patients with cutaneous (n=7), inhalation (n=2), and gastrointestinal (n=1) disease. Anthrax Immune Globulin (AIG), which has been used in treatment of clinical anthrax, interfered with detection of PA. This study demonstrates a culture-independent method of diagnosing anthrax through use of monoclonal antibodies to detect PA and LF in the lethal toxin complex. PMID:24857756

  13. Detection of anthrax protective antigen (PA) using europium labeled anti-PA monoclonal antibody and time-resolved fluorescence.

    PubMed

    Stoddard, Robyn A; Quinn, Conrad P; Schiffer, Jarad M; Boyer, Anne E; Goldstein, Jason; Bagarozzi, Dennis A; Soroka, Stephen D; Dauphin, Leslie A; Hoffmaster, Alex R

    2014-06-01

    Inhalation anthrax is a rare but acute infectious disease following adsorption of Bacillus anthracis spores through the lungs. The disease has a high fatality rate if untreated, but early and correct diagnosis has a significant impact on case patient recovery. The early symptoms of inhalation anthrax are, however, non-specific and current anthrax diagnostics are primarily dependent upon culture and confirmatory real-time PCR. Consequently, there may be a significant delay in diagnosis and targeted treatment. Rapid, culture-independent diagnostic tests are therefore needed, particularly in the context of a large scale emergency response. The aim of this study was to evaluate the ability of monoclonal antibodies to detect anthrax toxin proteins that are secreted early in the course of B. anthracis infection using a time-resolved fluorescence (TRF) immunoassay. We selected monoclonal antibodies that could detect protective antigen (PA), as PA83 and also PA63 and LF in the lethal toxin complex. The assay reliable detection limit (RDL) was 6.63×10(-6)μM (0.551ng/ml) for PA83 and 2.51×10(-5)μM (1.58ng/ml) for PA63. Despite variable precision and accuracy of the assay, PA was detected in 9 out of 10 sera samples from anthrax confirmed case patients with cutaneous (n=7), inhalation (n=2), and gastrointestinal (n=1) disease. Anthrax Immune Globulin (AIG), which has been used in treatment of clinical anthrax, interfered with detection of PA. This study demonstrates a culture-independent method of diagnosing anthrax through the use of monoclonal antibodies to detect PA and LF in the lethal toxin complex. Published by Elsevier B.V.

  14. Insights Into the PA Neutral Atom: from AN Evaluation of PA2+ Outer-Core Correlation Energy Calculations

    NASA Astrophysics Data System (ADS)

    Mrozik, Michael K.; Pitzer, Russell M.; Bursten, Bruce E.

    2010-06-01

    Since the identification of f-orbital contribution to the bonding in PaO+, investigations into Pa cations have hoped to characterize as many of the electronic states possible.1 Electronic states of the Pan+ (n=0-4) ions have been investigated using multi-reference spin-orbit configuration interaction (MR-SOCI). Initial investigations using Dunning style correlation consistent double-{ζ} basis sets are re-examined with a larger triple-{ζ} basis, with the hope of supporting the order of electronic states. Calculations using Hartree-Fock and CI calculations on the neutral atom did not produce the known order of states. A case study was deemed necessary on similar electron configurations present in the low energy states of Pa2+ more specifically those generated from the 5f26d1 and 5f16d2 configurations. Comparison in the Pa2+ ion is complicated by the lack of experimental results, but the states are presumed to be similar sequence as those in the neutral atom, with the addition of two electrons in the 7s shell. In evaluating the impact of inclusion of the outer core, calculations including valence-outer core correlation were completed for the 5d, 6s, and 6p shells of the Pa2+ ion. The magnitude of these individual shell correlation calculations will allow for identification of the energy level shifts associated with even and odd configurations, better describing the energy order in both the Pa2+ ion case study and for the neutral Pa atom. Upon completion of this aspect of the Pa neutral atom study, the knowledge of the energy levels in the Pan+ (n=0-4) family of ions will be greatly expanded, and may yield a model for future studies of atomic actinide systems. Gibson {et al.} Organometallics 2007, 26, 3947-3956.

  15. Public transit generates new physical activity: Evidence from individual GPS and accelerometer data before and after light rail construction in a neighborhood of Salt Lake City, Utah, USA

    PubMed Central

    Miller, Harvey J.; Tribby, Calvin P.; Brown, Barbara B.; Smith, Ken R.; Werner, Carol M.; Wolf, Jean; Wilson, Laura; Simas Oliveira, Marcelo G.

    2015-01-01

    Poor health outcomes from insufficient physical activity (PA) are a persistent public health issue. Public transit is often promoted for positive influence on PA. Although there is cross-sectional evidence that transit users have higher PA levels, this may be coincidental or shifted from activities such as recreational walking. We use a quasi-experimental design to test if light rail transit (LRT) generated new PA in a neighborhood of Salt Lake City, Utah, USA. Participants (n=536) wore Global Positioning System (GPS) receivers and accelerometers before (2012) and after (2013) LRT construction. We test within-person differences in individuals’ PA time based on changes in transit usage pre- versus post-intervention. We map transit-related PA to detect spatial clustering of PA around the new transit stops. We analyze within-person differences in PA time based on daily transit use and estimate the effect of daily transit use on PA time controlling for socio-demographic variables. Results suggest that transit use directly generates new PA that is not shifted from other PA. This supports the public health benefits from new high quality public transit such as LRT. PMID:26340643

  16. Public transit generates new physical activity: Evidence from individual GPS and accelerometer data before and after light rail construction in a neighborhood of Salt Lake City, Utah, USA.

    PubMed

    Miller, Harvey J; Tribby, Calvin P; Brown, Barbara B; Smith, Ken R; Werner, Carol M; Wolf, Jean; Wilson, Laura; Oliveira, Marcelo G Simas

    2015-11-01

    Poor health outcomes from insufficient physical activity (PA) are a persistent public health issue. Public transit is often promoted for positive influence on PA. Although there is cross-sectional evidence that transit users have higher PA levels, this may be coincidental or shifted from activities such as recreational walking. We use a quasi-experimental design to test if light rail transit (LRT) generated new PA in a neighborhood of Salt Lake City, Utah, USA. Participants (n=536) wore Global Positioning System (GPS) receivers and accelerometers before (2012) and after (2013) LRT construction. We test within-person differences in individuals' PA time based on changes in transit usage pre- versus post-intervention. We map transit-related PA to detect spatial clustering of PA around the new transit stops. We analyze within-person differences in PA time based on daily transit use and estimate the effect of daily transit use on PA time controlling for socio-demographic variables. Results suggest that transit use directly generates new PA that is not shifted from other PA. This supports the public health benefits from new high quality public transit such as LRT. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Crystal structure of the flavoenzyme PA4991 from Pseudomonas aeruginosa

    SciTech Connect

    Jacewicz, Agata; Schnell, Robert; Lindqvist, Ylva; Schneider, Gunter

    2016-01-22

    PA4991 is a FAD-dependent oxidoreductase from the pathogen P. aeruginosa that is essential for virulence and survival in the infected host. The structure of this enzyme, determined to 2.4 Å resolution, reveals that PA4991 belongs to the GR{sub 2} family of flavoenzymes. The locus PA4991 in Pseudomonas aeruginosa encodes an open reading frame that has been identified as essential for the virulence and/or survival of this pathogenic organism in the infected host. Here, it is shown that this gene encodes a monomeric FAD-binding protein of molecular mass 42.2 kDa. The structure of PA4991 was determined by a combination of molecular replacement using a search model generated with Rosetta and phase improvement by a low-occupancy heavy-metal derivative. PA4991 belongs to the GR{sub 2} family of FAD-dependent oxidoreductases, comprising an FAD-binding domain typical of the glutathione reductase family and a second domain dominated by an eight-stranded mixed β-sheet. Most of the protein–FAD interactions are via the FAD-binding domain, but the isoalloxazine ring is located at the domain interface and interacts with residues from both domains. A comparison with the structurally related glycine oxidase and glycerol-3-phosphate dehydrogenase shows that in spite of very low amino-acid sequence identity (<18%) several active-site residues involved in substrate binding in these enzymes are conserved in PA4991. However, enzymatic assays show that PA4991 does not display amino-acid oxidase or glycerol-3-phosphate dehydrogenase activities, suggesting that it requires different substrates for activity.

  18. Brightside Academy: Pittsburgh, Pennsylvania

    ERIC Educational Resources Information Center

    Horn, Sarah

    2009-01-01

    Since its inception in 1992, Brightside Academy has been providing quality care to children six weeks to 12 years old. Operating 49 locations in Pennsylvania, Ohio, and New York, the company is committed to strengthening learners and respecting families. Currently, the organization provides early education for 6,700 children on a daily basis. 90%…

  19. 75 FR 7407 - Airworthiness Directives; Piper Aircraft, Inc. Models PA-32R-301T and PA-46-350P Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-19

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; Piper Aircraft, Inc... airworthiness directive (AD) for certain Piper Aircraft, Inc. Models PA-32R-301T and PA-46-350P airplanes. This... installed on certain Piper Aircraft, Inc. Models PA-32R-301T and PA-46-350P airplanes are failing. The V...

  20. 231Pa systematics in postglacial volcanic rocks from Iceland

    NASA Astrophysics Data System (ADS)

    Turner, Simon; Kokfelt, Thomas; Hoernle, Kaj; Lundstrom, Craig; Hauff, Folkmar

    2016-07-01

    Several recent studies have highlighted the potential of combined 238U-230Th and 235U-231Pa systematics to constrain upwelling rates and the role of recycled mafic lithologies in mantle plume-derived basalts. Accordingly, we present measurements of the 231Pa concentrations from 26 mafic volcanic rocks from Iceland, including off-axis basalts from the Snaefellsnes Peninsula, to complement previously published 238U-230Th-226Ra data. 231Pa concentrations vary from 27 to 624 fg/g and (231Pa/235U) ratios from 1.12 to 2.11 with the exception of one anomalous sample from the Southeast Rift which has a 231Pa deficit with (231Pa/235U) = 0.86. An important new result is that basalts from the Southeast Rift and the Snaefellsnes Peninsula define a trend at relatively low (231Pa/235U) for a given (230Th/238U) ratio. Many of the remaining samples fall in or around the global field for ocean island basalts but those from the Mid-Iceland Belt and the Southwest Rift/Reykjanes Peninsula extend to higher (231Pa/235U) ratios at a given (230Th/238U), similar to mid-ocean ridge basalts. In principle, these lavas could result from melting of peridotite at lower pressures. However, there is no reason to suspect that the Mid-Iceland Belt and the Southwest Rift lavas reflect shallower melting than elsewhere in Iceland. In our preferred model, these lavas reflect melting of garnet peridotite whereas those from the Southeast Rift and the Snaefellsnes Peninsula contain a significant contribution (up to 20%) of melt from garnet pyroxenite. This is consistent with incompatible trace element and radiogenic isotope evidence for recycled oceanic crust in these lavas. There is increasing agreement that the displacement of ocean island basalts to lower (231Pa/235U) ratios at a given (230Th/238U), compared to mid-ocean ridge basalts, reflects the role of recycled mafic lithologies such as garnet pyroxenite as well as higher average pressures of melting. It now seems likely that this interpretation may

  1. Crystal structure of the flavoenzyme PA4991 from Pseudomonas aeruginosa

    PubMed Central

    Jacewicz, Agata; Schnell, Robert; Lindqvist, Ylva; Schneider, Gunter

    2016-01-01

    The locus PA4991 in Pseudomonas aeruginosa encodes an open reading frame that has been identified as essential for the virulence and/or survival of this pathogenic organism in the infected host. Here, it is shown that this gene encodes a monomeric FAD-binding protein of molecular mass 42.2 kDa. The structure of PA4991 was determined by a combination of molecular replacement using a search model generated with Rosetta and phase improvement by a low-occupancy heavy-metal derivative. PA4991 belongs to the GR2 family of FAD-dependent oxidoreductases, comprising an FAD-binding domain typical of the glutathione reductase family and a second domain dominated by an eight-stranded mixed β-sheet. Most of the protein–FAD interactions are via the FAD-binding domain, but the isoalloxazine ring is located at the domain interface and interacts with residues from both domains. A comparison with the structurally related glycine oxidase and glycerol-3-phosphate dehydrogenase shows that in spite of very low amino-acid sequence identity (<18%) several active-site residues involved in substrate binding in these enzymes are conserved in PA4991. However, enzymatic assays show that PA4991 does not display amino-acid oxidase or glycerol-3-phosphate dehydrogenase activities, suggesting that it requires different substrates for activity. PMID:26841760

  2. Morphological studies on block copolymer modified PA 6 blends

    NASA Astrophysics Data System (ADS)

    Poindl, M.; Bonten, C.

    2014-05-01

    Recent studies show that compounding polyamide 6 (PA 6) with a PA 6 polyether block copolymers made by reaction injection molding (RIM) or continuous anionic polymerization in a reactive extrusion process (REX) result in blends with high impact strength and high stiffness compared to conventional rubber blends. In this paper, different high impact PA 6 blends were prepared using a twin screw extruder. The different impact modifiers were an ethylene propylene copolymer, a PA PA 6 polyether block copolymer made by reaction injection molding and one made by reactive extrusion. To ensure good particle matrix bonding, the ethylene propylene copolymer was grafted with maleic anhydride (EPR-g-MA). Due to the molecular structure of the two block copolymers, a coupling agent was not necessary. The block copolymers are semi-crystalline and partially cross-linked in contrast to commonly used amorphous rubbers which are usually uncured. The combination of different analysis methods like atomic force microscopy (AFM), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) gave a detailed view in the structure of the blends. Due to the partial cross-linking, the particles of the block copolymers in the blends are not spherical like the ones of ethylene propylene copolymer. The differences in molecular structure, miscibility and grafting of the impact modifiers result in different mechanical properties and different blend morphologies.

  3. Morphological studies on block copolymer modified PA 6 blends

    SciTech Connect

    Poindl, M. E-mail: christian.bonten@ikt.uni-stuttgart.de; Bonten, C. E-mail: christian.bonten@ikt.uni-stuttgart.de

    2014-05-15

    Recent studies show that compounding polyamide 6 (PA 6) with a PA 6 polyether block copolymers made by reaction injection molding (RIM) or continuous anionic polymerization in a reactive extrusion process (REX) result in blends with high impact strength and high stiffness compared to conventional rubber blends. In this paper, different high impact PA 6 blends were prepared using a twin screw extruder. The different impact modifiers were an ethylene propylene copolymer, a PA PA 6 polyether block copolymer made by reaction injection molding and one made by reactive extrusion. To ensure good particle matrix bonding, the ethylene propylene copolymer was grafted with maleic anhydride (EPR-g-MA). Due to the molecular structure of the two block copolymers, a coupling agent was not necessary. The block copolymers are semi-crystalline and partially cross-linked in contrast to commonly used amorphous rubbers which are usually uncured. The combination of different analysis methods like atomic force microscopy (AFM), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) gave a detailed view in the structure of the blends. Due to the partial cross-linking, the particles of the block copolymers in the blends are not spherical like the ones of ethylene propylene copolymer. The differences in molecular structure, miscibility and grafting of the impact modifiers result in different mechanical properties and different blend morphologies.

  4. Efficacy of histotripsy combined with rt-PA in vitro

    NASA Astrophysics Data System (ADS)

    Bader, Kenneth B.; Haworth, Kevin J.; Shekhar, Himanshu; Maxwell, Adam D.; Peng, Tao; McPherson, David D.; Holland, Christy K.

    2016-07-01

    Histotripsy, a form of therapeutic ultrasound that uses the mechanical action of microbubble clouds for tissue ablation, is under development to treat chronic deep vein thrombosis (DVT). We hypothesize that combining thrombolytic agents with histotripsy will enhance clot lysis. Recombinant tissue plasminogen activator (rt-PA) and rt-PA-loaded echogenic liposomes that entrain octafluoropropane microbubbles (OFP t-ELIP) were used in combination with highly shocked histotripsy pulses. Fully retracted porcine venous clots, with similar features of DVT occlusions, were exposed either to histotripsy pulses alone (peak negative pressures of 7-20 MPa), histotripsy and OFP t-ELIP, or histotripsy and rt-PA. Microbubble cloud activity was monitored with passive cavitation imaging during histotripsy exposure. The power levels of cavitation emissions from within the clot were not statistically different between treatment types, likely due to the near instantaneous rupture and destruction of OFP t-ELIP. The thrombolytic efficacy was significantly improved in the presence of rt-PA. These results suggest the combination of histotripsy and rt-PA could serve as a potent therapeutic strategy for the treatment of DVT.

  5. Cross-cultural adaptation of the assistive technology device - Predisposition assessment (ATD PA) for use in Brazil (ATD PA Br).

    PubMed

    Alves, Ana Cristina de Jesus; Matsukura, Thelma Simões; Scherer, Marcia J

    2017-02-01

    The purpose of this study is to conduct a cross-cultural adaptation of the Assistive Technology Device Predisposition Assessment (ATD PA) for use in Brazil. The selection of the Assistive Technology Device Predisposition Assessment (ATD PA) was determined by previous literature reviews of articles published in 2014 and 2016 in six databases with the terms "assistive device" or "assistive technology" or "self-help device" combined with "evidence-based practice" or "framework" or "measurement scale" or "model and outcome assessment". This review indicated that the conceptual model of Assistive Technology (AT) most discussed in the literature was the Matching Person and Technology (MPT) model, and this finding determined the selection of ATD PA as an assessment within the MPT portfolio of measures. The procedures for cross-cultural adaptation were as follows: Equivalence of Concept, Semantic and Operational. Five experts were asked to translate 725 items and these translations were evaluated and a high level of agreement was demonstrated. The Portuguese version, Avaliação de Tecnologia Assistiva - Predisposição ao Uso - ATD PA Br, was derived from the original version in English (ATD PA). The ATD PA Br will support professionals and people with disabilities in Brazil to better select AT devices according to the clients' needs. Implications for rehabilitation Provides a systematic way of selecting assistive technology devices for the use of individuals with disabilities according to the Brazilian reality. A systematic way of selecting the assistive technology that can help decrease the abandonment of the assistive technology use. The use of the Matching Person and Technology theorical model and of the assessment ATD PA Br is essential to guide the researches and clinical practice in Brazil.

  6. Calibration of PM2.5 mass concentrations used in the Pittsburgh Aerosol Research and Inhalation Epidemiology Study

    NASA Astrophysics Data System (ADS)

    Bilonick, Richard A.; Connell, Daniel P.; Talbott, Evelyn O.; Xue, Tao; Rager, Judith R.

    2015-08-01

    Fifteen different types of PM2.5 mass concentration samplers were used by seven different monitoring networks at 47 locations in the Pittsburgh, Pennsylvania, region from 1999 to 2008. The samplers included Federal Reference Method (FRM) samplers, speciation samplers, tapered element oscillating microbalance (TEOM) samplers, and others. The different measurement principles used in these designs tended to lead to systematic differences (biases) when measuring the same quantity, and to differences in the typical size of random errors (imprecision) introduced by each type of sampler. Bias can take different forms either as a constant bias or as a non-constant (scale) bias, which depends on the size of the quantity being measured. The objective of the work presented here was to simultaneously calibrate the measurements made by these different samplers to remove relative biases (both constant and non-constant) so that all of the available PM2.5 data could be used interchangeably to develop exposure estimates for a retrospective epidemiology study. In order to accomplish this, we used linked temperature-stratified structural equation models, nonlinear regression models, and nonlinear mixed effects models. Applying these methods we constructed a comprehensive measurement error model that included both systematic error and random error components, and derived calibration equations that can be applied to place all of the PM2.5 mass concentration measurements on the same scale. The FRM sampler was used as the reference scale although the parameter estimates are invariant to this choice. Results showed that: (1) 50 °C TEOM samplers tended to show a large downward bias relative to the FRM sampler at low temperatures, and the magnitude of this bias decreased according to a nonlinear (sigmoidal) pattern with increasing temperature, (2) speciation samplers and other integrated samplers generally showed smaller biases relative to the FRM sampler that were not temperature

  7. Binding of (11)C-Pittsburgh compound-B correlated with white matter injury in hypertensive small vessel disease.

    PubMed

    Hashimoto, Tetsuya; Yokota, Chiaki; Koshino, Kazuhiro; Temma, Takashi; Yamazaki, Makoto; Iguchi, Satoshi; Shimomura, Ryo; Uehara, Toshiyuki; Funatsu, Naoko; Hino, Tenyu; Minematsu, Kazuo; Iida, Hidehiro; Toyoda, Kazunori

    2017-04-01

    (11)C-Pittsburgh compound-B ((11)C-PIB) positron emission tomography (PET) is used to visualize and quantify amyloid deposition in the brain cortex in pathological conditions such as Alzheimer's disease (AD). Intense (11)C-PIB retention is also observed in the white matter (WM) of both healthy individuals and AD patients. However, the clinical implications of this retention in brain WM have not been clarified. We investigated the relationship between the extent of white matter lesions (WMLs) and the binding potential of (11)C-PIB (BPND) in the WM in patients with hypertensive small vessel disease. We further examined the relationship between the extent of WMLs and BPND in WML and in normal-appearing white matter (NAWM). Twenty-one hypertensive vasculopathy patients, without AD and major cerebral arterial stenosis and/or occlusion, were enrolled (9 women, 68 ± 7 years). Regions of WML and NAWM were extracted using magnetization-prepared rapid gradient-echo and fluid-attenuated inversion recovery of magnetic resonance images. Volumes of interest (VOIs) were set in the cortex-subcortex, basal ganglia, and centrum semiovale (CS). BPND in the cortex-subcortex, basal ganglia, CS, WML, and NAWM were estimated on (11)C-PIB PET using Logan graphical analysis with cerebellar regions as references. The relationships between WML volume and BPND in each region were examined by linear regression analysis. BPND was higher in the CS and basal ganglia than in the cortex-subcortex regions. WML volume had a significant inverse correlation with BPND in the CS (Slope = -0.0042, R (2)  = 0.44, P < 0.01). For intra WM comparison, BPND in NAWM was significantly higher than that in WML. In addition, although there were no correlations between WML volume and BPND in WML, WML volume was significantly correlated inversely with BPND in NAWM (Slope = -0.0017, R (2)  = 0.26, P = 0.02). (11)C-PIB could be a marker of not only cortical amyloid-β deposition but also

  8. The impact of three recent coal-fired power plant closings on Pittsburgh air quality: A natural experiment.

    PubMed

    Russell, Marie C; Belle, Jessica H; Liu, Yang

    2017-01-01

    Relative to the rest of the United States, the region of southwestern Pennsylvania, including metropolitan Pittsburgh, experiences high ambient concentrations of fine particulate matter (PM2.5), which is known to be associated with adverse respiratory and cardiovascular health impacts. This study evaluates whether the closing of three coal-fired power plants within the southwestern Pennsylvania region resulted in a significant decrease in PM2.5 concentration. Both PM2.5 data obtained from EPA ground stations in the study region and aerosol optical depth (AOD) data retrieved from the Moderate Resolution Imaging Spectroradiometer (MODIS) instruments onboard the Terra and Aqua satellites were used to investigate regional air quality from January 2011 through December 2014. The impact of the plant closings on PM2.5 concentration and AOD was evaluated using a series of generalized additive models. The model results show that monthly fuel consumption of the Elrama plant, which closed in October of 2012, and monthly fuel consumption of both the Mitchell and Hatfield's Ferry plants, which closed in October of 2013, were significant predictors of both PM2.5 concentration and AOD at EPA ground stations in the study region, after controlling for multiple meteorological factors and long-term, region-wide air quality improvements. The model's power to predict PM2.5 concentration increased from an adjusted R(2) of 0.61 to 0.68 after excluding data from ground stations with higher uncertainty due to recent increases in unconventional natural gas extraction activities. After preliminary analyses of mean PM2.5 concentration and AOD showed a downward trend following each power plant shutdown, results from a series of generalized additive models confirmed that the activity of the three plants that closed, measured by monthly fuel consumption, was highly significant in predicting both AOD and PM2.5 at 12 EPA ground stations; further research on PM2.5 emissions from unconventional

  9. Characterizing Regional Correlation, Laterality and Symmetry of Amyloid Deposition in Mild Cognitive Impairment and Alzheimer's Disease with Pittsburgh Compound B

    PubMed Central

    Raji, Cyrus A.; Becker, James T.; Tsopelas, Nicholas D.; Price, Julie C.; Mathis, Chester A.; Saxton, Judith A.; Lopresti, Brian J.; Hoge, Jessica A.; Ziolko, Scott K.; DeKosky, Steven T.; Klunk, William E.

    2008-01-01

    We evaluated the region-to-region correlation, laterality and asymmetry of amyloid deposition in subjects with mild cognitive impairment (MCI) or Alzheimer's Disease (AD) using the amyloid tracer, Pittsburgh-Compound B (PiB). Seventeen subjects, including 7 with MCI (MMSE 26.7 ± 2.4) and 10 with AD (MMSE of 24.8 ± 2.7) underwent PiB imaging. Measures of laterality (i.e. group-wise predilection for right or left) and asymmetry (i.e. group-wise predilection for unequal PiB retention between the two hemispheres) were calculated for seventeen Regions of Interest (ROIs). Regional correlations were calculated along with within-group and between-groups statistical analyses of laterality and asymmetry metrics. The median correlation between PiB retention across all pairs of ROIs was 0.65, with highest correlations found in areas of highest PiB retention, (r = 0.74). Overall, PiB retention was symmetric bilaterally, but there was PiB laterality in MCI in dorsal frontal cortex [(t(6) = 3.05, p = 0.02, L>R] and sensory-motor area [t(6) = 3.10, p = 0.02, L>R] and in AD in the occipital pole (t(9) = −2.63, p = 0.03, R>L). The most significant asymmetries in PiB retention were found in sub-cortical white matter (t(6) = 3.99, p = 0.01) and middle precuneus [(t(6) = 3.57, p = 0.01] in MCI, and in lateral temporal cortex (t(9) = 3.02, p = 0.01) and anterior ventral striatum [t(9) = 2.37, p = 0.04] in AD. No group differences (AD versus MCI) were detected in laterality [F (1,15)= 0.15, p= 0.7] or asymmetry [F (1, 15) = 0.7, p = 0.42]. PMID:18582948

  10. Dyslexia Laws in the USA

    ERIC Educational Resources Information Center

    Youman, Martha; Mather, Nancy

    2013-01-01

    Throughout the various states of the USA, the appropriate identification of dyslexia and the timely provision of interventions are characterized by variability and inconsistency. Several states have recognized the existence of this disorder and the well-established need for services. These states have taken proactive steps to implement laws and…

  11. Dyslexia Laws in the USA

    ERIC Educational Resources Information Center

    Youman, Martha; Mather, Nancy

    2013-01-01

    Throughout the various states of the USA, the appropriate identification of dyslexia and the timely provision of interventions are characterized by variability and inconsistency. Several states have recognized the existence of this disorder and the well-established need for services. These states have taken proactive steps to implement laws and…

  12. USA Science and Engineering Festival

    NASA Image and Video Library

    2010-10-22

    Visitors crowd the NASA exhibits during the USA Science and Engineering Festival, Saturday, Oct. 23, 2010, on the National Mall in Washington. NASA, joined with more than 500 science organizations this weekend to inspire the next generation of scientists and engineers during the first national science and engineering festival held in the nation's capital. Photo Credit: (NASA/Paul E. Alers)

  13. USA Science and Engineering Festival

    NASA Image and Video Library

    2010-10-22

    Participants look through telescopes to observe the Sun during the USA Science and Engineering Festival, Saturday, Oct. 23, 2010, at Freedom Plaza in Washington. NASA, joined with more than 500 science organizations this weekend to inspire the next generation of scientists and engineers during the first national science and engineering festival held in the nation's capital. Photo Credit: (NASA/Paul E. Alers)

  14. USA Science and Engineering Festival

    NASA Image and Video Library

    2010-10-22

    Visitors to the USA Science and Engineering Festival look over the many exhibits, Saturday, Oct. 23, 2010, at Freedom Plaza in Washington. NASA, joined with more than 500 science organizations this weekend to inspire the next generation of scientists and engineers during the first national science and engineering festival held in the nation's capital. Photo Credit: (NASA/Paul E. Alers)

  15. [Hyalomatrix PA(®) in skin substitutes. About 10 cases].

    PubMed

    Perrot, P; Dellière, V; Brancati, A; Duteille, F

    2011-04-01

    During the surgical treatment of burns and reconstructive surgery, we can use autografts, allografts, xenografts or dermal substitutes. Acellular dermal substitutes, implantable medical devices of class III are composed mostly of collagen but also, more recently, derivatives of hyaluronic acid (Hyalomatrix PA(®)). Their mechanism of action is based on revascularization and colonization by fibroblasts of the patient. They are then used to screen for delayed epidermal grafting (2-stage procedure for Integra(®), Matriderm(®) 2mm, Renoskin(®), Hyalomatrix PA(®)) or simultaneous (1-time procedure for IntegraSL(®), Matriderm(®) 1mm). We report 10 cases of clinical use of Hyalomatrix PA(®) in the service of burns and plastic surgery of Nantes. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

  16. 77 FR 6587 - Startek USA, Inc. Alexandria, LA; Startek USA, Inc., Collinsville, VA; Amended Certification...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-08

    ... Employment and Training Administration Startek USA, Inc. Alexandria, LA; Startek USA, Inc., Collinsville, VA..., applicable to workers of StarTek USA, Inc., Alexandria, Louisiana. The workers are engaged in the supply of..., Virginia location of StarTek USA, Inc. supplied call center services such as sales and technical...

  17. Shuttle GPS R/PA configuration and specification study

    NASA Technical Reports Server (NTRS)

    Booth, R. W. D.

    1979-01-01

    Changes in the technical specifications for a global positioning system (GPS) receiving system dedicated to space shuttle use are presented. Various hardware functions including acquisition, tracking, and measurement are emphasized. The anti-jam performance of the baseline GPS systems are evaluated. Other topics addressed include: the impact on R/PA design of the use of ground based transmitters; problems involved with the use of single channel tests sets; utility of various R/PA antenna interconnections topologies; the choice of the averaging interval for delta range measurements; and the use of interferometry techniques for the computation of orbiter attitude were undertaken.

  18. Accreditation and implications of clinical postgraduate PA training programs.

    PubMed

    Hussaini, Sobia S; Bushardt, Reamer L; Gonsalves, Wanda C; Hilton, Virginia O; Hornberger, Brad J; Labagnara, Frank A; OʼHara, Kevin M; Sasek, Cody; Smith, Benjamin J; Williams, Jennifer S

    2016-05-01

    No consensus definition exists for postgraduate physician assistant (PA) training. This report from the AAPA Task Force on Accreditation of Postgraduate PA Training Programs describes the types of clinical training programs and their effects on hiring and compensation of PAs. Although completing a postgraduate program appears to have no effect on compensation, PAs who complete these programs may be favored in the hiring process and frequently report greater confidence in their skills. More research is needed and program accreditation is key to monitoring the effectiveness of these programs.

  19. Impact of telemedicine implementation in thrombolytic use for acute ischemic stroke: the University of Pittsburgh Medical Center telestroke network experience.

    PubMed

    Amorim, Edilberto; Shih, Min-Mei; Koehler, Steven A; Massaro, Lori L; Zaidi, Syed F; Jumaa, Mouhammad A; Reddy, Vivek K; Hammer, Maxim D; Jovin, Tudor G; Wechsler, Lawrence R

    2013-05-01

    Intravenous thrombolysis is the only therapy for acute ischemic stroke that is approved by the US Food and Drug Association. The use of telemedicine in stroke makes it possible to bring the expertise of academic stroke centers to underserved areas, potentially increasing the quality of stroke care. All consecutive admissions for stroke were reviewed for 1 year before telemedicine implementation and for variable periods thereafter. A retrospective review identified 2588 admissions for acute stroke between March 2005 and December 2008 at 12 hospitals participating in a telestroke network, including 919 patients before telemedicine was available and 1669 patients after telemedicine was available. The primary outcome measure was the rate of intravenous tissue plasminogen activator (IV tPA) use before and after telemedicine implementation. One hundred thirty-nine patients received IV tPA in both study phases, with 26 (2.8%) patients treated before starting telemedicine and 113 (6.8%) after starting telemedicine (P < .001). Incorrect treatment decisions occurred 7 times (0.39%), with 2 (0.2%) pretelemedicine and 5 (0.3%) posttelemedicine (P = .70). Arrivals within 3 hours from symptom onset were more frequent in the posttelemedicine compared to the pretelemedicine phases (55 [6%] vs 159 [9.5%]; P = .002). Among the patients treated with IV tPA, symptomatic intracranial hemorrhage occurred in 2 patients (1 [10.7%] pretelemedicine vs 1 [1.8%] posttelemedicine; P = .34). Telestroke implementation was associated with an increased rate of thrombolytic use in remote hospitals within the telemedicine network. Copyright © 2013 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  20. Apportionment of ambient primary and secondary fine particulate matter during a 2001 summer intensive study at the CMU Supersite and NETL Pittsburgh site.

    PubMed

    Eatough, Delbert J; Mangelson, Nolan F; Anderson, Richard R; Martello, Donald V; Pekney, Natalie J; Davidson, Cliff I; Modey, William K

    2007-10-01

    Gaseous and particulate pollutant concentrations associated with five samples per day collected during a July 2001 summer intensive study at the Pittsburgh Carnegie Mellon University (CMU) Supersite were used to apportion fine particulate matter (PM2.5) into primary and secondary contributions using PMF2. Input to the PMF2 analysis included the concentrations of PM2.5 nonvolatile and semivolatile organic material, elemental carbon (EC), ammonium sulfate, trace element components, gas-phase organic material, and NO(x), NO2, and O3 concentrations. A total of 10 factors were identified. These factors are associated with emissions from various sources and facilities including crustal material, gasoline combustion, diesel combustion, and three nearby sources high in trace metals. In addition, four secondary sources were identified, three of which were associated with secondary products of local emissions and were dominated by organic material and one of which was dominated by secondary ammonium sulfate transported to the CMU site from the west and southwest. The three largest contributors to PM2.5 were secondary transported material (dominated by ammonium sulfate) from the west and southwest (49%), secondary material formed during midday photochemical processes (24%), and gasoline combustion emissions (11%). The other seven sources accounted for the remaining 16% of the PM2.5. Results obtained at the CMU site were comparable to results previously reported at the National Energy Technology Laboratory (NETL), located approximately 18 km south of downtown Pittsburgh. The major contributor at both sites was material transported from the west and southwest. Some difference in nearby sources could be attributed to meteorology as evaluated by HYSPLIT model back-trajectory calculations. These findings are consistent with the majority of the secondary ammonium sulfate in the Pittsburgh area being the result of contributions from distant transport, and thus decoupled from local

  1. Oxidation of Gas-Phase Protactinium Ions, Pa+ and Pa2+: Formation and Properties of PaO22+(g), Protactinyl

    SciTech Connect

    Santos, M.; de Matos, A. Pires; Marcalo, J.; Gibson, John K; Haire, Richard {Dick} G; Tyagi, R.; Pitzer, R. M.

    2006-01-01

    Oxidation reactions of bare and ligated, monopositive, and dipositive Pa ions in the gas phase were studied by Fourier transform ion cyclotron resonance mass spectrometry. Seven oxidants were employed, ranging from the thermodynamically robust N{sub 2}O to the relatively weak CH{sub 2}O - all oxidized Pa{sup +} to PaO{sup +} and PaO{sup +} to PaO{sub 2}{sup +}. On the basis of experimental observations, it was established that D[Pa{sup +}-O] and D[OPa{sup +}-O] {ge} 751 kJ mol{sup -1}. Estimates for D[Pa{sup +}-O], D[OPa{sup +}-O], IE[PaO], and IE[PaO{sub 2}] were also obtained. The seven oxidants reacted with Pa{sup 2+} to produce PaO{sup 2+}, indicating that D[Pa{sup 2+}-O] {ge} 751 kJ mol{sup -1}. A particularly notable finding was the oxidation of PaO{sup 2+} by N{sub 2}O to PaO{sub 2}{sup 2+}, a species, which formally comprises Pa(VI). Collision-induced dissociation of PaO{sub 2}{sup 2+} suggested the protactinyl connectivity, {l_brace}O-Pa-O{r_brace}{sup 2+}. The experimentally determined IE[PaO{sub 2}{sup +}] {approx} 16.6 eV is in agreement with self-consistent-field and configuration interaction calculations for PaO{sub 2}{sup +} and PaO{sub 2}{sup 2+}. These calculations provide insights into the electronic structures of these ions and indicate the participation of 5f orbitals in bonding and a partial '6p hole' in the case of protactinyl. It was found that PaO{sub 2}{sup 2+} catalyzes the oxidation of CO by N{sub 2}O - such O atom transport via a dipositive metal oxide ion is distinctive. It was also observed that PaO{sub 2}{sup 2+} is capable of activating H{sub 2} to form the stable PaO{sub 2}H{sup 2+} ion.

  2. 14. FROM 30th STREET COACH YARDS, LOOKING WEST, ABUTS PA3813 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. FROM 30th STREET COACH YARDS, LOOKING WEST, ABUTS PA-38-13 AND PA-38-15. - Pennsylvania Railroad, West Philadelphia Elevated, Parallel to Schuylkill River, north of Arsenal Bridge, Philadelphia, Philadelphia County, PA

  3. First trimester exposure to ambient air pollution, pregnancy complications and adverse birth outcomes in Allegheny County, PA.

    PubMed

    Lee, Pei-Chen; Roberts, James M; Catov, Janet M; Talbott, Evelyn O; Ritz, Beate

    2013-04-01

    Despite numerous studies of air pollution and adverse birth outcomes, few studies have investigated preeclampsia and gestational hypertension, two pregnancy disorders with serious consequences for both mother and infant. Relying on hospital birth records, we conducted a cohort study identifying 34,705 singleton births delivered at Magee-Women's Hospital in Pittsburgh, PA between 1997 and 2002. Particle (<10 μm-PM10; <2.5 μm-PM2.5) and ozone (O3) exposure concentrations in the first trimester of pregnancy were estimated using the space-time ordinary Kriging interpolation method. We employed multiple logistic regression estimate associations between first trimester exposures and preeclampsia, gestational hypertension, preterm delivery, and small for gestational age (SGA) infants. PM2.5 and O3 exposures were associated with preeclampsia (adjusted OR = 1.15, 95% CI = 0.96-1.39 per 4.0 μg/m(3) increase in PM2.5; adjusted OR = 1.12, 95% CI = 0.89-1.42 per 16.8 ppb increase in O3), gestational hypertension (for PM2.5 OR = 1.11, 95 % CI = 1.00-1.23; for O3 OR = 1.12, 95 % CI = 0.97-1.29), and preterm delivery (for PM2.5 ORs = 1.10, 95% CI = 1.01-1.20; for O3 ORs = 1.23, 95% CI = 1.01-1.50). Smaller 5-8 % increases in risk were also observed for PM10 with gestational hypertension and SGA, but not preeclampsia. Our data suggest that first trimester exposure to particles, mostly PM2.5, and ozone, may increase the risk of developing preeclampsia and gestational hypertension, as well as preterm delivery and SGA.

  4. Apparatus to measure the vapor pressure of slowly decomposing compounds from 1 Pa to 10(5) Pa.

    PubMed

    Berg, Robert F

    2015-11-01

    This article describes an apparatus and method for measuring vapor pressures in the range from 1 Pa to 10(5) Pa. Its three distinctive elements are : (1) the static pressure measurements were made with only a small temperature difference between the vapor and the condensed phase, (2) the sample was degassed in situ, and (3) the temperature range extended up to 200 °C. The apparatus was designed to measure metal-organic precursors, which often are toxic, pyrophoric, or unstable. Vapor pressures are presented for naphthalene, ferrocene, diethyl phthalate, and TEMAH (tetrakisethylmethylaminohafnium). Also presented are data for the temperature-dependent decomposition rate of TEMAH.

  5. PA103 Container Pallet MIL-STD-1660 Tests.

    DTIC Science & Technology

    1996-02-01

    Research, Development and Engineering Center (ARDEC) to conduct MIL- STD -1660 tests on PA103 containers unitized on a pallet with dunnage assemblies...supplied by Olin Ordnance. This report contains test results with the palletized unit load tested failing to meet MIL- STD -1660, Design Criteria for

  6. 76 FR 61130 - Pennsylvania Disaster Number PA-00044

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-03

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Pennsylvania Disaster Number PA-00044 AGENCY: U.S. Small Business Administration. ACTION.../2011 is hereby amended to include the following areas as adversely affected by the disaster:...

  7. ANALYSIS OF ATMOSPHERE DEPOSITION SAMPLES FROM EASTON, PA

    EPA Science Inventory

    The report gives results of an analysis of samples of tenacious atmospheric deposits on exposed surfaces (e.g., automobiles and houses) in an industrial area near Easton, PA. The analysis was made at the request of the State of Pennsylvania. The Pennsylvania Department of Environ...

  8. 76 FR 68803 - Pennsylvania Disaster Number PA-00044

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ... [Federal Register Volume 76, Number 215 (Monday, November 7, 2011)] [Notices] [Page 68803] [FR Doc... Disaster Number PA-00044 AGENCY: U.S. Small Business Administration. ACTION: Amendment 3. SUMMARY: This is... remains unchanged. (Catalog of Federal Domestic Assistance Numbers 59002 and 59008) James E. Rivera...

  9. 78 FR 48296 - Amendment of Class E Airspace; Factoryville, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Factoryville, PA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E... in the Federal Register a notice of proposed rulemaking (NPRM) to amend Class E airspace at...

  10. 77 FR 45240 - Establishment of Class E Airspace; Quakertown, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-31

    ... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Quakertown, PA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action establishes Class E... published in the Federal Register a notice of proposed rulemaking to establish Class E airspace...

  11. 77 FR 16669 - Establishment of Class E Airspace; Bellefonte, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    ... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Bellefonte, PA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action establishes Class E... Federal Register a notice of proposed rulemaking (NPRM) to establish Class E airspace 700 feet above...

  12. 76 FR 28895 - Safety Zone; Ohio River, Sewickley, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-19

    ... based on the USACE's Ohio River Navigation Charts (Chart 1, January 2003). (b) Effective date. This rule... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Ohio River, Sewickley, PA AGENCY: Coast... zone on specified waters of the Ohio River in Sewickley, Pennsylvania. The safety zone is needed to...

  13. Tissue Plasminogen Activator (tPA) Mediates Neurotoxin-Induced Cell Death and Microglial Activation

    DTIC Science & Technology

    2001-07-01

    Alzheimer’s disease and stroke. Tissue plasminogen activator (tPA), a protease converting plasminogen to plasmin, is necessary for neurodegeneration. In mice lacking tPA (tPA-/1), neurons are resistant to neurotoxic death. Delivery of tPA into tpA-/- mice restores susceptibility to neuronal death, indicating that tPA is neurotoxic in the context of excitotoxic injury. Although tPA is synthesized by neurons, the increase in tPA upon injury derives primarily from activated microglia, the immune cells of the brain. Microglia in tPA-/- mice demonstrate reduced activation.

  14. Diabetes Prevention and Treatment Programs for Western PA FY04 and FY05

    DTIC Science & Technology

    2009-05-01

    Michelle Noschese, Monica Dinardo, Glory Koerbel, Michelle Curll, Melissa Saul, Mary Korytkowski. Impact of a Targeted Glycemic Management...Hospital: Experience with 50 Patients using Continuous Subcutaneous Insulin Infusions Michelle Noschese, Amy Calabrese Donihi, Kris Ruppert, Monica...Jim Barron (consultant) Academic Site Participant: University of Pittsburgh Diabetes Institute; Linda Siminerio, director; Janice McWilliams, project

  15. Draft Genome Sequences of Pseudomonas fluorescens Strains PA4C2 and PA3G8 and Pseudomonas putida PA14H7, Three Biocontrol Bacteria against Dickeya Phytopathogens

    PubMed Central

    Cigna, Jérémy; Raoul des Essarts, Yannick; Mondy, Samuel; Hélias, Valérie; Beury-Cirou, Amélie

    2015-01-01

    Pseudomonas fluorescens strains PA4C2 and PA3G8 and Pseudomonas putida strain PA14H7 were isolated from potato rhizosphere and show an ability to inhibit the growth of Dickeya phytopathogens. Here, we report their draft genome sequences, which provide a basis for understanding the molecular mechanisms involved in antibiosis against Dickeya. PMID:25635023

  16. USA Science and Engineering Festival

    NASA Image and Video Library

    2010-10-23

    Young visitors to the inaugural USA Science and Engineering Festival at the National Mall in Washington, D.C., learn about the life cycle of a star at an exhibit sponsored by the John C. Stennis Space Center Education Office. Stennis personnel participated in the final weekend of the Oct. 10-24 festival with education activities and to present information on its new Spaced Out Sports Design Challenge.

  17. Houston/Galveston, Texas, USA

    NASA Image and Video Library

    1991-09-18

    In this view of Houston/Galveston, Texas, USA (29.5N, 95.5W), heavy spring rains emphasize the several bodies of water in the area. Even though partially cloud covered, the progressive nature of the Houston highway and freeway system can easily be observed in this highly detailed view. To the south, the NASA, Clear Lake area just off of Galveston Bay can easily be seen. In the center, is the downtown business district.

  18. USA Science and Engineering Festival

    NASA Image and Video Library

    2010-10-22

    Children react as a tiny Mars Rover rolls over their backs at the USA Science and Engineering Festival, Saturday, Oct. 23, 2010, at Freedom Plaza in Washington. NASA, joined with more than 500 science organizations this weekend to inspire the next generation of scientists and engineers during the first national science and engineering festival held in the nation's capital. Photo Credit: (NASA/Paul E. Alers)

  19. USA Science and Engineering Festival

    NASA Image and Video Library

    2010-10-22

    Visitors to the USA Science and Engineering Festival look on at one of the many exhibits, Saturday, Oct. 23, 2010, on the National Mall in Washington. NASA, joined with more than 500 science organizations this weekend to inspire the next generation of scientists and engineers during the first national science and engineering festival held in the nation's capital. Photo Credit: (NASA/Paul E. Alers)

  20. USA Science and Engineering Festival

    NASA Image and Video Library

    2010-10-22

    Priniciples of air flow are explained to visitors to the wind tunnel exhibit at the USA Science and Engineering Festival, Saturday, Oct. 23, 2010, at Freedom Plaza in Washington. NASA, joined with more than 500 science organizations this weekend to inspire the next generation of scientists and engineers during the first national science and engineering festival held in the nation's capital. Photo Credit: (NASA/Paul E. Alers)

  1. USA Science and Engineering Festival

    NASA Image and Video Library

    2010-10-22

    A young girl watches as her paper airplane is flown in a small wind tunnel during the USA Science and Engineering Festival, Saturday, Oct. 23, 2010, at Freedom Plaza in Washington. NASA, joined with more than 500 science organizations this weekend to inspire the next generation of scientists and engineers during the first national science and engineering festival held in the nation's capital. Photo Credit: (NASA/Paul E. Alers)

  2. Thunderstorm, Texas Gulf Coast, USA

    NASA Image and Video Library

    1990-04-29

    This thunderstorm along the Texas Gulf Coast (29.0N, 95.0W), USA is seen as the trailing edge of a large cloud mass formed along the leading edge of a spring frontal system stretching northwest to southeast across the Texas Gulf Coast. This system brought extensive severe weather and flooding to parts of Texas and surrounding states. Muddy water discharging from coastal streams can be seen in the shallow Gulf of Mexico as far south as Lavaca Bay.

  3. Neutralisation of uPA with a monoclonal antibody reduces plasmin formation and delays skin wound healing in tPA-deficient mice.

    PubMed

    Jögi, Annika; Rønø, Birgitte; Lund, Ida K; Nielsen, Boye S; Ploug, Michael; Høyer-Hansen, Gunilla; Rømer, John; Lund, Leif R

    2010-09-15

    Proteolytic degradation by plasmin and metalloproteinases is essential for epidermal regeneration in skin wound healing. Plasminogen deficient mice have severely delayed wound closure as have mice simultaneously lacking the two plasminogen activators, urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA). In contrast, individual genetic deficiencies in either uPA or tPA lead to wound healing kinetics with no or only slightly delayed closure of skin wounds. To evaluate the therapeutic potential in vivo of a murine neutralizing antibody directed against mouse uPA we investigated the efficacy in skin wound healing of tPA-deficient mice. Systemic administration of the anti-mouse uPA monoclonal antibody, mU1, to tPA-deficient mice caused a dose-dependent delay of skin wound closure almost similar to the delayed kinetics observed in uPA;tPA double-deficient mice. Analysis of wound extracts showed diminished levels of plasmin in the mU1-treated tPA-deficient mice. Immunohistochemistry revealed that fibrin accumulated in the wounds of such mU1-treated tPA-deficient mice and that keratinocyte tongues were aberrant. Together these abnormalities lead to compromised epidermal closure. Our findings demonstrate that inhibition of uPA activity with a monoclonal antibody in adult tPA-deficient mice mimics the effect of simultaneous genetic ablation of uPA and tPA. Thus, application of the murine inhibitory mU1 antibody provides a new and highly versatile tool to interfere with uPA-activity in vivo in mouse models of disease.

  4. Psychometric Characteristics of the Pittsburgh Sleep Quality Index in English Speaking Non-Hispanic Whites and English and Spanish Speaking Hispanics of Mexican Descent

    PubMed Central

    Tomfohr, Lianne M.; Schweizer, C. Amanda; Dimsdale, Joel E.; Loredo, José S.

    2013-01-01

    Study Objectives: The current study investigated the factor structure of the Pittsburgh Sleep Quality Index (PSQI) among English speaking non-Hispanic whites (NHW) and English and Spanish speaking Hispanics of Mexican descent (HMD). Design: The PSQI was administered during a telephone interview. In order to test the factor structure of the PSQI structure across ethnic/language groups, multiple group confirmatory analysis with covariates (MIMIC) was employed. The 1- and 3-factor versions of the PSQI previously reported in the literature were examined. Setting: San Diego County. Participants: Community-dwelling English speaking, NHW (n = 1,698) and English (n = 654) and Spanish (n = 792) speaking HMD. Measurement and Results: A single-factor scoring model fit across language/ethnic groups; however, a 3-factor model provided a better than the 1-factor model in all language/ethnic groups. The subscale sleep medications loaded poorly and was removed from all models. Conclusion: Across groups, a 3-factor model of the PSQI more reliably assessed sleep quality than a single-factor global score. Results indicate that the 3-factor structure of the PSQI was uniform across English speaking NHW and English and Spanish speaking HMD. Citation: Tomfohr LM; Schweizer CA; Dimsdale JE; Loredo JS. Psychometric characteristics of the Pittsburgh Sleep Quality Index in English speaking non-Hispanic whites and English and Spanish speaking Hispanics of Mexican descent. J Clin Sleep Med 2013;9(1):61-66. PMID:23319906

  5. The Online Bioinformatics Resources Collection at the University of Pittsburgh Health Sciences Library System--a one-stop gateway to online bioinformatics databases and software tools.

    PubMed

    Chen, Yi-Bu; Chattopadhyay, Ansuman; Bergen, Phillip; Gadd, Cynthia; Tannery, Nancy

    2007-01-01

    To bridge the gap between the rising information needs of biological and medical researchers and the rapidly growing number of online bioinformatics resources, we have created the Online Bioinformatics Resources Collection (OBRC) at the Health Sciences Library System (HSLS) at the University of Pittsburgh. The OBRC, containing 1542 major online bioinformatics databases and software tools, was constructed using the HSLS content management system built on the Zope Web application server. To enhance the output of search results, we further implemented the Vivísimo Clustering Engine, which automatically organizes the search results into categories created dynamically based on the textual information of the retrieved records. As the largest online collection of its kind and the only one with advanced search results clustering, OBRC is aimed at becoming a one-stop guided information gateway to the major bioinformatics databases and software tools on the Web. OBRC is available at the University of Pittsburgh's HSLS Web site (http://www.hsls.pitt.edu/guides/genetics/obrc).

  6. Psychometric assessment of subjective sleep quality using the Japanese version of the Pittsburgh Sleep Quality Index (PSQI-J) in psychiatric disordered and control subjects.

    PubMed

    Doi, Y; Minowa, M; Uchiyama, M; Okawa, M; Kim, K; Shibui, K; Kamei, Y

    2000-12-27

    Subjective sleep quality has been identified as an important clinical construct in psychiatric disordered patients. The Pittsburgh Sleep Quality Index (PSQI), one of the most widely used standardized measures to assess subjective sleep quality, generates a global score and scores seven components. The present study psychometrically assessed clinical profiles of subjective sleep quality in 82 control and 92 psychiatric disordered subjects (primary insomnia, n=14; major depression, n=30; generalized anxiety disorder, n=24; and schizophrenia, n=24), using the Japanese version of the Pittsburgh Sleep Quality Index (PSQI-J). The overall reliability coefficient of the PSQI-J was high (Cronbach's alpha=0.77). Correlation coefficients between the PSQI-J global and component scores were statistically significant. The PSQI-J global and component mean scores were significantly higher in psychiatric disordered subjects than control subjects, except for the component of sleep duration. Using a cut-off point of 5.5 in the PSQI-J global score, estimations of sensitivity and specificity provided 85.7 and 86.6% for primary insomnia, 80.0 and 86.6% for major depression, 83.3 and 86.6% for generalized anxiety disorder, and 83.3 and 86.6% for schizophrenia, respectively. The present study supports the utility of the PSQI-J as a reliable and valid measure for subjective sleep quality in clinical practice and research.

  7. Evaluation of latent tuberculous infection and treatment completion for refugees in Philadelphia, PA, 2010-2012.

    PubMed

    Subedi, P; Drezner, K A; Dogbey, M C; Newbern, E C; Yun, K; Scott, K C; Garland, J M; Altshuler, M J; Johnson, C C

    2015-05-01

    Philadelphia, PA, USA. To compare the evaluation and treatment of latent tuberculous infection (LTBI) in refugees seen at member clinics of the Philadelphia Refugee Health Collaborative (PRHC) vs. non-PRHC clinics. Refugees with Class B (non-communicable) tuberculosis (TB) admitted to the United States from 2010 to 2012 who were being treated at PRHC clinics were compared to those treated at non-PRHC clinics. Odds ratios (ORs) for attending a follow-up appointment, completing treatment, and time from arrival to the United States to the first TB screening test were calculated. Of the 2094 refugees who arrived in Philadelphia in 2010-2012, the Philadelphia Department of Public Health was notified of 149 who required additional evaluation for TB. Among these, 57 (38.3%) were confirmed to have LTBI, and none were diagnosed with active TB. All LTBI cases were recommended for anti-tuberculosis prophylaxis and 43 (75.4%) completed treatment. Refugees receiving care from PRHC clinics were more likely to be screened within 30 days of arrival (OR 4.70, 95%CI 2.12-10.44), attend a follow-up appointment (OR 4.53, 95%CI 1.36-16.27), and complete treatment (OR 9.44, 95%CI 2.39-37.3). Refugees who attended PRHC clinics were more likely to be evaluated promptly and to complete LTBI treatment. The PRHC clinics serve as a model for communities seeking to improve refugee health care.

  8. FOREWORD: CCM Second International Seminar: Pressure Metrology from 1 kPa to 1 GPa

    NASA Astrophysics Data System (ADS)

    Molinar, G. F.

    1994-01-01

    The Comité Consultatif pour la Masse et les Grandeurs Apparentées (CCM), through its High Pressure and Medium Pressure Working Groups, organized this Second International Seminar on Pressure Metrology from 1 kPa to 1 GPa, which was held at the Laboratoire National d'Essais (LNE), Paris, France, from 2 to 4 June 1993. The scope of the seminar was to review the state of the art of pressure measurements in the 1 kPa to I GPa pressure range and to present innovative contributions by standards laboratories, universities and industry. The seminar was organized in six sessions: liquid-column manometers; piston gauge pressure standards; properties of liquids and gases relevant to pressure metrology; pressure transducers and transfer standards; pressure standard comparison (methods and results); dynamic pressure measurements. Each session opened with the presentation of a review paper on major requirements in that field and, at the end of the seminar, a general discussion was organized on the actual limits of accuracy of static and dynamic pressure measurements in fluid media, and the fundamental problems in pressure metrology between 1 kPa and 1 GPa. The seminar was attended by sixty scientists from twenty-four countries, all working in the field of pressure measurements. Forty-nine papers were presented. The participation of scientists from so many countries indicates the importance of pressure metrology from the scientific and industrial points of view. Most papers were presented by scientists from national standards laboratories, with eight papers from universities and four from industry. Eleven papers reported the results of cooperative work involving metrological institutions dealing with high pressure, generally national standards laboratories, an indication that scientific links are already well established at this level. Links are also strengthening between industry and standards laboratories. Although industrial participation at the seminar was relatively small

  9. Enhanced Production of Pediocin PA-1 and Coproduction of Nisin and Pediocin PA-1 by Lactococcus lactis

    PubMed Central

    Horn, Nikki; Martínez, María I.; Martínez, José M.; Hernández, Pablo E.; Gasson, Michael J.; Rodríguez, Juan M.; Dodd, Helen M.

    1999-01-01

    The production and secretion of class II bacteriocins share a number of features that allow the interchange of genetic determinants between certain members of this group of antimicrobial peptides. Lactococcus lactis IL1403 encodes translocatory functions able to recognize and mediate secretion of lactococcin A. The ability of this strain to also produce the pediococcal bacteriocin pediocin PA-1, has been demonstrated previously by the introduction of a chimeric gene, composed of sequences encoding the leader of lactococcin A and the mature part of pediocin PA-1 (N. Horn, M. I. Martínez, J. M. Martínez, P. E. Hernández, M. J. Gasson, J. M. Rodríguez, and H. M. Dodd, Appl. Environ. Microbiol. 64:818–823, 1998). This heterologous expression system has been developed further with the introduction of the lactococcin A-dedicated translocatory function genes, lcnC and lcnD, and their effect on bacteriocin yields in various lactococcal hosts was assessed. The copy number of lcnC and lcnD influenced production levels, as did the particular strain employed as host. Highest yields were achieved with L. lactis IL1403, which generated pediocin PA-1 at a level similar to that for the parental strain, Pediococcus acidilactici 347, representing a significant improvement over previous systems. The genetic determinants required for production of pediocin PA-1 were introduced into the nisin-producing strain L. lactis FI5876, where both pediocin PA-1 and nisin A were simultaneously produced. The implications of coproduction of these two industrially relevant antimicrobial agents by a food-grade organism are discussed. PMID:10508073

  10. Impact of National Physical Activity and Health Guidelines and Documents on Research on Teaching K-12 Physical Education in U.S.A.

    ERIC Educational Resources Information Center

    Li, Weidong; Xiang, Ping; Gao, Zan; Shen, Bo; Yin, Zhihua; Kong, Qingtao

    2016-01-01

    Purpose: This study examined the impact of published national physical activity (PA) and health guidelines, documents, and initiatives on the evolution of research on teaching K-12 physical education (PE) in U.S.A. from 1996 to October 2013. Methods: A total of 262 peer-reviewed, data-based journal articles meeting our inclusion and exclusion…

  11. Impact of National Physical Activity and Health Guidelines and Documents on Research on Teaching K-12 Physical Education in U.S.A.

    ERIC Educational Resources Information Center

    Li, Weidong; Xiang, Ping; Gao, Zan; Shen, Bo; Yin, Zhihua; Kong, Qingtao

    2016-01-01

    Purpose: This study examined the impact of published national physical activity (PA) and health guidelines, documents, and initiatives on the evolution of research on teaching K-12 physical education (PE) in U.S.A. from 1996 to October 2013. Methods: A total of 262 peer-reviewed, data-based journal articles meeting our inclusion and exclusion…

  12. Notification: Northwest Indian Fisheries Commission’s Puget Sound Protection and Restoration Implementation cooperative agreements PA00J32201 and PA00J91201

    EPA Pesticide Factsheets

    May 27, 2016. The EPA OIG plans to begin preliminary research on the Northwest Indian Fisheries Commission’s (NWIFC’s) Puget Sound Protection and Restoration Implementation cooperative agreements PA00J32201 and PA00J91201.

  13. Genomic structural characterization and transcriptional expression analysis of proteasome activator PA28α and PA28β subunits from Oplegnathus fasciatus.

    PubMed

    Kasthuri, Saranya Revathy; Umasuthan, Navaneethaiyer; Whang, Ilson; Kim, Eunmi; Park, Hae-Chul; Lee, Jehee

    2013-10-01

    Proteasomes are multicatalytic subunit complexes involved in the degradation of cytosolic proteins and antigen presentation. In this study, we have characterized the alpha and beta subunits of proteasome activator complex from rock bream at the molecular level. RbPA28α and RbPA28β possessed the characteristic features of the subunits identified from mammals and teleosts. The RbPA28α and RbPA28β proteasome subunits contained a proline-rich motif (Region A), subunit-specific insert in the region corresponding to the KEKE motif of the known PA28α (Region B), conserved activation loop (Region C), a potential protein kinase C recognition site (Region D) and a highly homologous C-terminal region (Region E) among all three PA28 subunits. Multiple sequence alignment and pairwise alignment revealed that RbPA28α and RbPA28β proteins shared high homology with the teleosts and mammals. RbPA28α and RbPA28β genome possessed 11 exons interrupted by 10 introns. In silico promoter analysis of RbPA28α and RbPA28β revealed various transcription factor-binding sites displaying their regulation under various stress conditions. Tissue distribution profiling showed a higher expression in blood and gills. Transcriptional expression analysis of RbPA28α and RbPA28β showed up-regulation in the immune tissues following LPS and poly I:C challenges, providing further evidence for the immunological role of RbPA28α and RbPA28β.

  14. Structure of a putative acetyltransferase (PA1377) from Pseudomonas aeruginosa

    SciTech Connect

    Davies, Anna M.; Tata, Renée; Chauviac, François-Xavier; Sutton, Brian J.; Brown, Paul R.

    2008-05-01

    The crystal structure of an acetyltransferase encoded by the gene PA1377 from Pseudomonas aeruginosa has been determined at 2.25 Å resolution. Comparison with a related acetyltransferase revealed a structural difference in the active site that was taken to reflect a difference in substrate binding and/or specificity between the two enzymes. Gene PA1377 from Pseudomonas aeruginosa encodes a 177-amino-acid conserved hypothetical protein of unknown function. The structure of this protein (termed pitax) has been solved in space group I222 to 2.25 Å resolution. Pitax belongs to the GCN5-related N-acetyltransferase family and contains all four sequence motifs conserved among family members. The β-strand structure in one of these motifs (motif A) is disrupted, which is believed to affect binding of the substrate that accepts the acetyl group from acetyl-CoA.

  15. Demonstration Assessment of LED Roadway Lighting: Philadelphia, PA

    SciTech Connect

    Royer, Michael P.; Tuenge, Jason R.; Poplawski, Michael E.

    2012-09-01

    For this demonstration assessment, 10 different groups of LED luminaires were installed at three sites in Philadelphia, PA. Each of the three sites represented a different set of conditions, most importantly with regard to the incumbent HPS luminaires, which were nominally 100 W, 150 W, and 250 W. The performance of each product was evaluated based on manufacturer data, illuminance calculations, field measurements of illuminance, and the subjective impressions of both regular and expert observers.

  16. Pa0148 from Pseudomonas aeruginosa Catalyzes the Deamination of Adenine†

    PubMed Central

    Goble, Alissa M.; Zhang, Zhening; Sauder, J. Michael; Burley, Stephen K.; Swaminathan, Subramanyam; Raushel, Frank M.

    2011-01-01

    Four proteins from NCBI cog1816, previously annotated as adenosine deaminases, have been subjected to structural and functional characterization. Pa0148 (Pseudomonas aeruginosa PAO1), AAur1117 (Arthrobacter aurescens TC1), Sgx9403e, and Sgx9403g, have been purified and their substrate profiles determined. Adenosine is not a substrate for any of these enzymes. All of these proteins will deaminate adenine to produce hypoxanthine with values of kcat/Km that exceed 105 M−1s−1. These enzymes will also accept 6-chloropurine, 6-methoxypurine, N-6-methyladenine, and 2,6-diaminopurine as alternate substrates. X-ray structures of Pa0148 and AAur1117 have been determined and reveal nearly identical distorted (β/α)8-barrels with a single zinc ion that is characteristic of members of the amidohydrolase superfamily. Structures of Pa0148 with adenine, 6-chloropurine and hypoxanthine were also determined thereby permitting identification of the residues responsible for coordinating the substrate and product. PMID:21710971

  17. PA-30 Twin Comanche - NASA 808 in flight

    NASA Technical Reports Server (NTRS)

    1979-01-01

    Dryden Flight Research Center's Piper PA-30 Twin Commanche, which helped validate the RPRV concept, descends to a remotely controlled landing on Rogers Dry Lake, unassisted by the onboard pilot. A Piper PA-30 Twin Commanche, known as NASA 808, was used at the NASA Dryden Flight Research Center as a rugged workhorse in a variety of research projects associated with both general aviation and military projects. In the early 1970s, the PA-30, serial number 301498, was used to test a flight technique used to fly Remotely Piloted Research Vehicles (RPRV's). The technique was first tested with the cockpit windows of the light aircraft blacked out while the pilot flew the aircraft utilizing a television monitor which gave him a 'pilot's eye' view ahead of the aircraft. Later pilots flew the aircraft from a ground cockpit, a procedure used with all RPRV's. TV and two-way telemetry allow the pilot to be in constant control of the aircraft. The apparatus mounted over the cockpit is a special fish eye lens camera, used to obtain images that are transmitted to the ground based cockpit. This project paved the way for sophisticated, highly successful research programs involving high risk spin, stall, and flight control conditions, such as the HiMAT and the subscale F-15 remotely piloted vehicles. Over the years, NASA 808 has also been used for spin and stall research related to general aviation aircraft and also research to alleviate wake vortices behind large jetliners.

  18. PA-30 Twin Comanche - NASA 808 in flight

    NASA Image and Video Library

    1971-10-08

    Dryden Flight Research Center's Piper PA-30 Twin Commanche, which helped validate the RPRV concept, descends to a remotely controlled landing on Rogers Dry Lake, unassisted by the onboard pilot. A Piper PA-30 Twin Commanche, known as NASA 808, was used at the NASA Dryden Flight Research Center as a rugged workhorse in a variety of research projects associated with both general aviation and military projects. In the early 1970s, the PA-30, serial number 301498, was used to test a flight technique used to fly Remotely Piloted Research Vehicles (RPRV's). The technique was first tested with the cockpit windows of the light aircraft blacked out while the pilot flew the aircraft utilizing a television monitor which gave him a "pilot's eye" view ahead of the aircraft. Later pilots flew the aircraft from a ground cockpit, a procedure used with all RPRV's. TV and two-way telemetry allow the pilot to be in constant control of the aircraft. The apparatus mounted over the cockpit is a special fish eye lens camera, used to obtain images that are transmitted to the ground based cockpit. This project paved the way for sophisticated, highly successful research programs involving high risk spin, stall, and flight control conditions, such as the HiMAT and the subscale F-15 remotely piloted vehicles. Over the years, NASA 808 has also been used for spin and stall research related to general aviation aircraft and also research to alleviate wake vortices behind large jetliners.

  19. Thermal degradation of PA66 during laser transmission welding

    NASA Astrophysics Data System (ADS)

    Wang, Xiao; Guo, Dehui; Chen, Guochun; Jiang, Hairong; Meng, Dongdong; Yan, Zhang; Liu, Huixia

    2016-09-01

    The thermal degradation of materials strongly influences the weld strength in laser transmission welding (LTW). Weld strength decreases at high temperatures because of material thermal degradation. Hence, it is necessary to investigate this phenomenon. Thermal degradation of polyamide 66 (PA66) was predicted by combining a pyrolysis kinetic model with a 3-D transient thermal model. Thermogravimetric analysis (TGA) was used to study the pyrolysis characteristic of PA66. The TGA data were used to obtain kinetic parameters of PA66 using an nth order model in MATLAB. In addition, material conversion as a function of temperature (time) was analyzed using this kinetic reaction model containing the relevant kinetic parameters. A 3-D transient thermal model based on a volumetric heat source was developed. The temperature-time data of the point located at the maximum temperature was predicted through this thermal analysis model under different weld parameters. This study demonstrates that the predicted power at which the material starts to degrade is generally consistent with the power at which shear strength begins to decrease. The present studies lay a theoretical foundation for the investigation of thermal degradation during LTW.

  20. Pa0148 from Pseudomonas aeruginosa Catalyzes the Deamination of Adenine

    SciTech Connect

    A Goble; Z Zhang; J Sauder; S Burley; S Swaminathan; F Raushel

    2011-12-31

    Four proteins from NCBI cog1816, previously annotated as adenosine deaminases, have been subjected to structural and functional characterization. Pa0148 (Pseudomonas aeruginosa PAO1), AAur1117 (Arthrobacter aurescens TC1), Sgx9403e, and Sgx9403g have been purified and their substrate profiles determined. Adenosine is not a substrate for any of these enzymes. All of these proteins will deaminate adenine to produce hypoxanthine with k{sub cat}/K{sub m} values that exceed 10{sup 5} M{sup -1} s{sup -1}. These enzymes will also accept 6-chloropurine, 6-methoxypurine, N-6-methyladenine, and 2,6-diaminopurine as alternate substrates. X-ray structures of Pa0148 and AAur1117 have been determined and reveal nearly identical distorted ({beta}/{alpha}){sub 8} barrels with a single zinc ion that is characteristic of members of the amidohydrolase superfamily. Structures of Pa0148 with adenine, 6-chloropurine, and hypoxanthine were also determined, thereby permitting identification of the residues responsible for coordinating the substrate and product.