Sample records for pittsburgh pa usa

  1. RadNet Air Data From Pittsburgh, PA

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Pittsburgh, PA from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  2. [Proceedings of the] International Conference on Educational Data Mining (EDM) (3rd, Pittsburgh, PA, July 11-13, 2010)

    ERIC Educational Resources Information Center

    Baker, Ryan S. J. d., Ed.; Merceron, Agathe, Ed.; Pavlik, Philip I., Jr., Ed.

    2010-01-01

    The Third International Conference on Data Mining (EDM 2010) was held in Pittsburgh, PA, USA. It follows the second conference at the University of Cordoba, Spain, on July 1-3, 2009 and the first edition of the conference held in Montreal in 2008, and a series of workshops within the AAAI, AIED, EC-TEL, ICALT, ITS, and UM conferences. EDM 2011…

  3. Martin Luther King, Jr. East Busway in Pittsburgh, PA

    DOT National Transportation Integrated Search

    1987-10-01

    The Port Authority of Allegheny County (PAT), the primary public transit operator in Pittsburgh, PA, built an exclusive roadway for buses which opened for service in February 1983. The two-lane, 6.8-mile facility serves the eastern suburbs via a righ...

  4. 76 FR 47993 - Safety Zone; Allegheny River; Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-08

    ... hazards associated with the Guyasuta Days Festival fireworks display. Entry into, movement within, and... possible hazards associated with the Guyasuta Days Festival fireworks display that will occur in the city... during the Guyasuta Days Festival fireworks display that will occur in the city of Pittsburgh, PA on...

  5. Lifestyle characteristics assessment of Japanese in Pittsburgh, USA.

    PubMed

    Hirooka, Nobutaka; Takedai, Teiichi; D'Amico, Frank

    2012-04-01

    Lifestyle-related chronic diseases such as cancer and cardiovascular disease are the greatest public health concerns. Evidence shows Japanese immigrants to a westernized environment have higher incidence of lifestyle-related diseases. However, little is known about lifestyle characteristics related to chronic diseases for Japanese in a westernized environment. This study is examining the gap in lifestyle by comparing the lifestyle prevalence for Japanese in the US with the Japanese National Data (the National Health and Nutrition Survey in Japan, J-NHANS) as well as the Japan National Health Promotion in the twenty-first Century (HJ21) goals. Japanese adults were surveyed in Pittsburgh, USA, regarding their lifestyle (e.g., diet, exercise, smoking, stress, alcohol, and oral hygiene). The prevalence was compared with J-NHANS and HJ21 goals. Ninety-three responded (response rate; 97.9%). Japanese men (n = 38) and women (n = 55) in Pittsburgh smoke less than Japanese in Japan (P < 0.001 for both genders). Japanese in Pittsburgh perform less physical activity in daily life and have lower prevalence of walking more than 1 h per day (P < 0.001 for both genders). Japanese women in Pittsburgh have significantly higher prevalence of stress than in Japan (P = 0.004). Japanese men in Pittsburgh do not reach HJ21 goal in weight management, BMI, use of medicine or alcohol to sleep, and sleep quality. Japanese women in Pittsburgh do not reach HJ21 goal in weight management and sleep quality. In conclusion, healthy lifestyle promotion including exercise and physical activity intervention for Japanese living in a westernized environment is warranted.

  6. 78 FR 22285 - Notice of Inventory Completion: Carnegie Museum of Natural History, Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ....R50000] Notice of Inventory Completion: Carnegie Museum of Natural History, Pittsburgh, PA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Carnegie Museum of Natural History has... associated funerary objects should submit a written request to the Carnegie Museum of Natural History. If no...

  7. EnviroAtlas -Pittsburgh, PA- One Meter Resolution Urban Land Cover Data (2010)

    EPA Pesticide Factsheets

    The EnviroAtlas Pittsburgh, PA land cover map was generated from United States Department of Agriculture (USDA) National Agricultural Imagery Program (NAIP) four band (red, green, blue, and near infrared) aerial photography at 1 m spatial resolution. Imagery was collected on multiple dates in June 2010. Five land cover classes were mapped: water, impervious surfaces, soil and barren land, trees and forest, and grass and herbaceous non-woody vegetation. An accuracy assessment of 500 completely random and 81 stratified random points yielded an overall accuracy of 86.57 percent. The area mapped is defined by the US Census Bureau's 2010 Urban Statistical Area for Pittsburgh, PA. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

  8. EnviroAtlas -Pittsburgh, PA- One Meter Resolution Urban Land Cover Data (2010) Web Service

    EPA Pesticide Factsheets

    This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://www.epa.gov/enviroatlas).The EnviroAtlas Pittsburgh, PA land cover map was generated from United States Department of Agriculture (USDA) National Agricultural Imagery Program (NAIP) four band (red, green, blue, and near infrared) aerial photography at 1 m spatial resolution. Imagery was collected on multiple dates in June 2010. Five land cover classes were mapped: water, impervious surfaces, soil and barren land, trees and forest, and grass and herbaceous non-woody vegetation. An accuracy assessment of 500 completely random and 81 stratified random points yielded an overall accuracy of 86.57 percent. The area mapped is defined by the US Census Bureau's 2010 Urban Statistical Area for Pittsburgh, PA. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

  9. 75 FR 9867 - University of Pittsburgh, et al

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... DEPARTMENT OF COMMERCE International Trade Administration University of Pittsburgh, et al.; Notice of Consolidated Decision on Applications for Duty-Free Entry of Electron Microscopes This is a...: University of Pittsburgh, Pittsburgh, PA 15260. Instrument: Electron Microscope. Manufacturer: JEOL, Ltd...

  10. 75 FR 56866 - Special Local Regulation; Monongahela River, Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-17

    ... participants of the Pittsburgh Dragon Boat Festival from the hazards imposed by marine traffic. Entry into the... Pittsburgh Dragon Boat Festival from the hazards imposed by marine traffic, and re-scheduling the event is... Festival from the hazards imposed by marine traffic, and re-scheduling the event is contrary to the public...

  11. PERSPECTIVE VIEW FROM NORTHWEST OF PITTSBURGH HIGH SCHOOL FOR THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PERSPECTIVE VIEW FROM NORTHWEST OF PITTSBURGH HIGH SCHOOL FOR THE CREATIVE AND PERFORMING ARTS, BUILT 2003 BY THE FIRM OF MACLACHLAN CORNELIUS AND FILONI. - Pittsburgh High School for the Creative & Performing Arts, 111 Ninth Street, Pittsburgh, Allegheny County, PA

  12. 3. Photocopy of original drawing belonging to the Pittsburgh Department ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Photocopy of original drawing belonging to the Pittsburgh Department of Public Works, (n.d.). DRAWING NO. 1963: STRESS AND SECTION SHEET FOR 531' STEEL SPANS. - North Side Point Bridge, Spanning Allegheny River at Point of Pittsburgh, Pittsburgh, Allegheny County, PA

  13. VIEW LOOKING NORTHEAST WITH OPEN HEARTH TO THE LEFT, PITTSBURGH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW LOOKING NORTHEAST WITH OPEN HEARTH TO THE LEFT, PITTSBURGH & LAKE ERIE RAILROAD TRACKS CENTER. - Pittsburgh Steel Company, Monessen Works, Open Hearth Plant, Donner Avenue, Monessen, Westmoreland County, PA

  14. Vulnerability studies and integrated assessments for hazard risk reduction in Pittsburgh, PA (Invited)

    NASA Astrophysics Data System (ADS)

    Klima, K.

    2013-12-01

    Today's environmental problems stretch beyond the bounds of most academic disciplines, and thus solutions require an interdisciplinary approach. For instance, the scientific consensus is changes in the frequency and severity of many types of extreme weather events are increasing (IPCC 2012). Yet despite our efforts to reduce greenhouse gases, we continue to experience severe weather events such as Superstorm Sandy, record heat and blizzards, and droughts. These natural hazards, combined with increased vulnerability and exposure, result in longer-lasting disruptions to critical infrastructure and business continuity throughout the world. In order to protect both our lives and the economy, we must think beyond the bounds of any one discipline to include an integrated assessment of relevant work. In the wake of recent events, New York City, Washington, DC, Chicago, and a myriad of other cities have turned to their academic powerhouses for assistance in better understanding their vulnerabilities. This talk will share a case study of the state of integrated assessments and vulnerability studies of energy, transportation, water, real estate, and other main sectors in Pittsburgh, PA. Then the talk will use integrated assessment models and other vulnerability studies to create coordinated sets of climate projections for use by the many public agencies and private-sector organizations in the region.

  15. Evidence for Type Ia Supernova Diversity from Ultraviolet Observations with the Hubble Space Telescope

    DTIC Science & Technology

    2012-04-20

    Observational Cosmology , NASA Goddard Space Flight Center, Code 665, Greenbelt, MD 20771, USA 31 Enrico Fermi Institute, Department of Physics, and Kavli...Institute for Cosmological Physics, University of Chicago, Chicago, IL 60637, USA 32 Department of Physics and Astronomy, Rutgers, the State University...Austin, TX 78712, USA 59 Pittsburgh Particle Physics, Astrophysics, and Cosmology Center (Pitt-PACC), University of Pittsburgh, Pittsburgh, PA 15260, USA

  16. 77 FR 47671 - TA-W-81,520, T-Mobile USA, Inc., Call Center, Allentown, PA; TA-W-81,520G, T-Mobile USA, Inc...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ... DEPARTMENT OF LABOR Employment and Training Administration TA-W-81,520, T-Mobile USA, Inc., Call Center, Allentown, PA; TA- W-81,520G, T-Mobile USA, Inc., Headquarters Office, Bellevue, WA; Amended... of T-Mobile USA, Inc., Call Center, Allentown, Pennsylvania (TA-W-81,520), Fort Lauderdale, Florida...

  17. 76 FR 55471 - Pittsburgh & West Virginia Railroad-Abandonment Exemption-in Allegheny County, PA; Wheeling...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-07

    ... Pittsburgh & West Virginia Railroad (PWV) and Wheeling & Lake Erie Railway Company (WLE) (collectively... Abandonments and Discontinuances of Service for PWV to abandon, and for WLE to discontinue its sublease rights... Service Zip Code 15220. Currently, PWV leases the line to Norfolk Southern Railway Company (NSR), which in...

  18. EnviroAtlas - Pittsburgh, PA - Ecosystem Services by Block Group

    EPA Pesticide Factsheets

    This EnviroAtlas dataset presents environmental benefits of the urban forest in 1,089 block groups in Pittsburgh, Pennsylvania. Carbon attributes, temperature reduction, pollution removal and value, and runoff effects are calculated for each block group using i-Tree models (www.itreetools.org), local weather data, pollution data, EPA provided city boundary and land cover data, and U.S. Census derived block group boundary data. This dataset was produced by the US Forest Service to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

  19. Development of a Formal Theory of Agent-Based Computing for System Evaluation and System-Design Guidance

    DTIC Science & Technology

    2004-06-01

    Department of EE and Computer Science University of Michigan Ann Arbor, MI 48109, USA pollackm@eecs.umich.edu Sujata Banerjeez Info. Sci. & Telecom. Dept...University of Pittsburgh Pittsburgh, PA 15260, USA sujata @tele.pitt.edu Abstract An important aspect of Business to Business E- Commerce is the agile

  20. Immunology in Pittsburgh.

    PubMed

    Finn, Olivera J; Salter, Russell D

    2006-01-01

    The University of Pittsburgh School of Medicine has a long tradition of excellence in immunology research and training. Faculty, students, and postdoctoral fellows walk through hallways that are pictorial reminders of the days when Dr. Jonas Salk worked here to develop the polio vaccine, or when Dr. Niels Jerne chaired the Microbiology Department and worked on perfecting the Jerne Plaque Assay for antibody-producing cells. Colleagues and postdoctoral fellows of Professor Salk are still on the faculty of the University of Pittsburgh Medical School as are graduate students of Professor Jerne. A modern research building, the 17 story high Biomedical Science Tower, is a vivid reminder of the day when Dr. Thomas Starzl arrived in Pittsburgh and started building the most prominent solid-organ-transplant program in the world. The immunology research that developed around the problem of graft rejection and tolerance induction trained numerous outstanding students and fellows. Almost 20 yr ago, the University of Pittsburgh founded the University of Pittsburgh Cancer Institute (UPCI) with the renowned immunologist Dr. Ronald Herberman at its helm. This started a number of new research initiatives in cancer immunology and immunotherapy. A large number of outstanding young investigators, as well as several well-established tumor immunologists, were recruited to Pittsburgh at that time.

  1. Rely-Guarantee Protocols

    DTIC Science & Technology

    2014-05-01

    University Pittsburgh, PA 15213 1School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA. 2Faculdade de Ciências e Tecnologia ...additional examples that are not in the ECOOP paper. This work was partially supported by Fundação para a Ciência e Tecnologia (Portuguese Foundation

  2. 77 FR 77016 - Foreign-Trade Zone 33 - Pittsburgh, Pennsylvania Notification of Proposed Export Production...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-31

    ... Confectionery Bars) Pittsburgh, PA Tsudis Chocolate Company (Tsudis), an operator of FTZ 33, submitted a... the facility would involve the production of chocolate confectionery bars for export (no shipments for... markets, FTZ procedures could exempt Tsudis from customs duty payments on the foreign status material used...

  3. The Eighth Data Release Of The Sloan Digital Sky Survey: First Data From SDSS-3

    DTIC Science & Technology

    2011-04-01

    Sunspot, NM 88349, USA 14 Center for Cosmology and Particle Physics, New York University, 4 Washington Place, New York, NY 10003, USA 15 Department of...Park, PA 16802, USA 18 Institute of Cosmology and Gravitation (ICG), Dennis Sciama Building, Burnaby Road, University of Portsmouth, Portsmouth, PO1 3FX... Cosmology , Carnegie Mellon University, Pittsburgh, P.A. 15213, USA 26 Yale Center for Astronomy and Astrophysics, Yale University, New Haven, CT 06520

  4. Pittsburgh-Tuskegee Prostate Training Program

    DTIC Science & Technology

    2013-05-01

    February 2012, Tuskegee University sophomore trainees will be selected as “Prostate Cancer Scholars” for summer internship at the University of...selected as “Prostate Cancer Scholars” for summer internship at the University of Pittsburgh. This is being reported on as the second group of... internship at the University of Pittsburgh. February – April 2012, Trainees will be selectively paired with University of Pittsburgh Faculty

  5. Our Pittsburgh Constellation

    NASA Astrophysics Data System (ADS)

    Turnshek, Diane

    2015-08-01

    Riding on the Pittsburgh mayor’s keen interest in astronomy and the ongoing change of 40,000 city lights from mercury and sodium vapor to shielded LEDs, we organized a series of city-wide celestial art projects to bring attention to the skies over Pittsburgh. Light pollution public talks were held at the University of Pittsburgh’s Allegheny Observatory and other colleges. Earth Hour celebrations kicked off an intensive year of astronomy outreach in the city. Lights went out on March 28, 2015 from 8:30 to 9:30 pm in over fifty buildings downtown and in Oakland (the “Eds and Meds” center, where many Pittsburgh universities and hospitals are located). Our art contest was announced at the De-Light Pittsburgh celebration at the Carnegie Science Center during Astronomy Weekend. “Our Pittsburgh Constellation” is an interactive Google map of all things astronomical in the city. Different colored stars mark locations of planetariums, star parties, classes, observatories, lecture series, museums, telescope manufacturers and participating art galleries. Contest entrants submitted artwork depicting their vision of the constellation figure that incorporates and connects all the “stars” in our custom city map. Throughout the year, over a dozen artists ran workshops on painting star clusters, galaxies, nebulae, comets, planets and aurorae with discussions of light pollution solutions and scientific explanations of what the patrons were painting, including demonstrations with emission tubes and diffraction grating glasses. We will display the celestial art created in this International Year of Light at an art gallery as part of the City’s Department of Innovation & Performance March 2016 Earth Hour gala. We are thankful for the Astronomical Footprint grant from the Heinz Endowments, which allowed us to bring the worlds of science and art together to enact social change.

  6. Emerald ash borer and the urban forest: Changes in landslide potential due to canopy loss scenarios in the City of Pittsburgh, PA.

    PubMed

    Pfeil-McCullough, Erin; Bain, Daniel J; Bergman, Jeffery; Crumrine, Danielle

    2015-12-01

    Emerald ash borer is expected to kill thousands of ash trees in the eastern U.S. This research develops tools to predict the effect of ash tree loss from the urban canopy on landslide susceptibility in Pittsburgh, PA. A spatial model was built using the SINMAP (Stability INdex MAPping) model coupled with spatially explicit scenarios of tree loss (0%, 25%, 50%, and 75% loss of ash trees from the canopy). Ash spatial distributions were estimated via Monte Carlo methods and available vegetation plot data. Ash trees are most prevalent on steeper slopes, likely due to urban development patterns. Therefore, ash loss disproportionately increases hillslope instability. A 75% loss of ash resulted in roughly 800 new potential landslide initiation locations. Sensitivity testing reveals that variations in rainfall rates, and friction angles produce minor changes to model results relative to the magnitude of parameter variation, but reveal high model sensitivity to soil density and root cohesion values. The model predictions demonstrate the importance of large canopy species to urban hillslope stability, particularly on steep slopes and in areas where soils tend to retain water. To improve instability predictions, better characterization of urban soils, particularly spatial patterns of compaction and species specific root cohesion is necessary. The modeling framework developed in this research will enhance assessment of changes in landslide risk due to tree mortality, improving our ability to design economically and ecologically sustainable urban systems. Copyright © 2015 Elsevier B.V. All rights reserved.

  7. View south of hydraulic hammer in boilermakers shop (probably the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View south of hydraulic hammer in boilermakers shop (probably the oldest piece of equipment in the yard, originally powered by steam) nameplate: United Engineers and FDRY. Co. Pittsburgh, Pa, USA Davy Brothers LTD. Patents - Aug 1, 1905, Feb, 1901, Sept 8, 1908 - 10000 lbs. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Structure Shop, League Island, Philadelphia, Philadelphia County, PA

  8. Simplified Space Conditioning in Low-Load Homes: Results from Pittsburgh, Pennsylvania, New Construction Unoccupied Test House

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Poerschke, Andrew; Stecher, Dave

    2014-06-01

    Field testing was performed in a new construction unoccupied test house in Pittsburgh, PA. Four air-based heating, ventilation, and air conditioning distribution systems—a typical airflow ducted system to the bedrooms, a low airflow ducted system to the bedrooms, a system with transfer fans to the bedrooms, and a system with no ductwork to the bedrooms—were evaluated during heating, cooling, and midseason conditions. The relative ability of each system was assessed with respect to relevant Air Conditioning Contractors of America and ASHRAE standards for house temperature uniformity and stability, respectively.

  9. Value-Added Models for the Pittsburgh Public Schools

    ERIC Educational Resources Information Center

    Johnson, Matthew; Lipscomb, Stephen; Gill, Brian; Booker, Kevin; Bruch, Julie

    2012-01-01

    At the request of Pittsburgh Public Schools (PPS) and the Pittsburgh Federation of Teachers (PFT), Mathematica has developed value-added models (VAMs) that aim to estimate the contributions of individual teachers, teams of teachers, and schools to the achievement growth of their students. The authors' work in estimating value-added in Pittsburgh…

  10. POLLUTION PREVENTION OPPORTUNITY ASSESSMENT UNITED STATES ARMY CORPS OF ENGINEERS PITTSBURGH ENGINEER WAREHOUSE AND REPAIR STATION AND EMSWORTH LOCKS AND DAMS PITTSBURGH, PENNSYLVANIA

    EPA Science Inventory

    This report summarizes work conducted at the United States Army Corps of Engineers (USACE) Pittsburgh Engineering Warehouse and Repair Station (PEWARS) and Emsworth Locks and Dams in Pittsburgh, Pennsylvania under the U.S. Environmental Protection Agency's (EPA's) Waste Reduction...

  11. University-School-Community Partnership as Vehicle for Leadership, Service, and Change: A Critical Brokerage Perspective

    ERIC Educational Resources Information Center

    Hopson, Rodney; Miller, Peter; Lovelace, Temple S.

    2016-01-01

    Using a critical brokerage perspective to advance theoretical insights in the development of a community university partnership and understanding of the organizational embeddedness of a community empowerment agency in Pittsburgh, PA, USA, this article suggests that partnerships between American universities and communities are perfect vehicles for…

  12. Social Contact Networks and Mixing among Students in K-12 Schools in Pittsburgh, PA

    PubMed Central

    Guclu, Hasan; Read, Jonathan; Vukotich, Charles J.; Galloway, David D.; Gao, Hongjiang; Rainey, Jeanette J.; Uzicanin, Amra; Zimmer, Shanta M.; Cummings, Derek A. T.

    2016-01-01

    Students attending schools play an important role in the transmission of influenza. In this study, we present a social network analysis of contacts among 1,828 students in eight different schools in urban and suburban areas in and near Pittsburgh, Pennsylvania, United States of America, including elementary, elementary-middle, middle, and high schools. We collected social contact information of students who wore wireless sensor devices that regularly recorded other devices if they are within a distance of 3 meters. We analyzed these networks to identify patterns of proximal student interactions in different classes and grades, to describe community structure within the schools, and to assess the impact of the physical environment of schools on proximal contacts. In the elementary and middle schools, we observed a high number of intra-grade and intra-classroom contacts and a relatively low number of inter-grade contacts. However, in high schools, contact networks were well connected and mixed across grades. High modularity of lower grades suggests that assumptions of homogeneous mixing in epidemic models may be inappropriate; whereas lower modularity in high schools suggests that homogenous mixing assumptions may be more acceptable in these settings. The results suggest that interventions targeting subsets of classrooms may work better in elementary schools than high schools. Our work presents quantitative measures of age-specific, school-based contacts that can be used as the basis for constructing models of the transmission of infections in schools. PMID:26978780

  13. Social Contact Networks and Mixing among Students in K-12 Schools in Pittsburgh, PA.

    PubMed

    Guclu, Hasan; Read, Jonathan; Vukotich, Charles J; Galloway, David D; Gao, Hongjiang; Rainey, Jeanette J; Uzicanin, Amra; Zimmer, Shanta M; Cummings, Derek A T

    2016-01-01

    Students attending schools play an important role in the transmission of influenza. In this study, we present a social network analysis of contacts among 1,828 students in eight different schools in urban and suburban areas in and near Pittsburgh, Pennsylvania, United States of America, including elementary, elementary-middle, middle, and high schools. We collected social contact information of students who wore wireless sensor devices that regularly recorded other devices if they are within a distance of 3 meters. We analyzed these networks to identify patterns of proximal student interactions in different classes and grades, to describe community structure within the schools, and to assess the impact of the physical environment of schools on proximal contacts. In the elementary and middle schools, we observed a high number of intra-grade and intra-classroom contacts and a relatively low number of inter-grade contacts. However, in high schools, contact networks were well connected and mixed across grades. High modularity of lower grades suggests that assumptions of homogeneous mixing in epidemic models may be inappropriate; whereas lower modularity in high schools suggests that homogenous mixing assumptions may be more acceptable in these settings. The results suggest that interventions targeting subsets of classrooms may work better in elementary schools than high schools. Our work presents quantitative measures of age-specific, school-based contacts that can be used as the basis for constructing models of the transmission of infections in schools.

  14. A Heat Vulnerability Index and Adaptation Solutions for Pittsburgh, Pennsylvania.

    PubMed

    Bradford, Kathryn; Abrahams, Leslie; Hegglin, Miriam; Klima, Kelly

    2015-10-06

    With increasing evidence of global warming, many cities have focused attention on response plans to address their populations' vulnerabilities. Despite expected increased frequency and intensity of heat waves, the health impacts of such events in urban areas can be minimized with careful policy and economic investments. We focus on Pittsburgh, Pennsylvania and ask two questions. First, what are the top factors contributing to heat vulnerability and how do these characteristics manifest geospatially throughout Pittsburgh? Second, assuming the City wishes to deploy additional cooling centers, what placement will optimally address the vulnerability of the at risk populations? We use national census data, ArcGIS geospatial modeling, and statistical analysis to determine a range of heat vulnerability indices and optimal cooling center placement. We find that while different studies use different data and statistical calculations, all methods tested locate additional cooling centers at the confluence of the three rivers (Downtown), the northeast side of Pittsburgh (Shadyside/Highland Park), and the southeast side of Pittsburgh (Squirrel Hill). This suggests that for Pittsburgh, a researcher could apply the same factor analysis procedure to compare data sets for different locations and times; factor analyses for heat vulnerability are more robust than previously thought.

  15. A Heat Vulnerability Index and Adaptation Solutions for Pittsburgh, Pennsylvania

    NASA Astrophysics Data System (ADS)

    Klima, K.; Abrahams, L.; Bradford, K.; Hegglin, M.

    2015-12-01

    With increasing evidence of global warming, many cities have focused attention on response plans to address their populations' vulnerabilities. Despite expected increased frequency and intensity of heat waves, the health impacts of such events in urban areas can be minimized with careful policy and economic investments. We focus on Pittsburgh, Pennsylvania and ask two questions. First, what are the top factors contributing to heat vulnerability and how do these characteristics manifest geospatially throughout Pittsburgh? Second, assuming the City wishes to deploy additional cooling centers, what placement will optimally address the vulnerability of the at risk populations? We use national census data, ArcGIS geospatial modeling, and statistical analysis to determine a range of heat vulnerability indices and optimal cooling center placement. We find that while different studies use different data and statistical calculations, all methods tested locate additional cooling centers at the confluence of the three rivers (Downtown), the northeast side of Pittsburgh (Shadyside/ Highland Park), and the southeast side of Pittsburgh (Squirrel Hill). This suggests that for Pittsburgh, a researcher could apply the same factor analysis procedure to compare datasets for different locations and times; factor analyses for heat vulnerability are more robust than previously thought.

  16. NARSTO EPA SS PITTSBURGH MET DATA

    Atmospheric Science Data Center

    2018-04-06

    ... Surface Pressure Solar Irradiance Ultraviolet Radiation Order Data:  Earthdata Search:   Order Data ... Earth Related Data:  Environmental Protection Agency Supersites Pittsburgh, Pennsylvania SCAR-B ...

  17. Preparing for Local Adaptation: Understanding Flood Risk Perceptions in Pittsburgh

    NASA Astrophysics Data System (ADS)

    Klima, K.; Wong-Parodi, G.

    2015-12-01

    The City of Pittsburgh experiences numerous floods every year. Aging and insufficient infrastructure contribute to flash floods and to over 20 billion gallons of combined sewer overflows annually, contaminating Pittsburgh's streets, basements, and waterways. Climate change is expected to further exacerbate this problem by causing more intense and more frequent extreme precipitation events in Western Pennsylvania. For a stormwater adaptation plan to be implemented effectively, the City will need informed public support. One way to achieve public understanding and support is through effective communication of the risks, benefits, and uncertainties of local flooding hazards and adaptation methods. In order to develop these communications effectively, the city and its partners will need to know what knowledge and attitudes the residents of Pittsburgh already hold about flood risks. Here we seek to (1) identify Pittsburgh residents' knowledge level, risk perception and attitudes towards flooding and storm water management, and (2) pre-test communications meant to inform and empower Pittsburghers about flood risks and adaptation strategies. We conduct a city-wide survey of 10,000 Pittsburgh renters and homeowners from four life situations: high risk, above poverty; high-risk, below poverty; low risk, above poverty; and low-risk, below poverty. Mixed media recruitment strategies (online and paper-based solicitations guided/organized by community organizations) assist in reaching all subpopulations. Preliminary results suggest participants know what stormwater runoff is, but have a weak understanding of how stormwater interacts with natural and built systems. Furthermore, although participants have a good understanding of the difference between green and gray infrastructure, this does not translate into a change in their willingness to pay for green infrastructure adaptation. This suggests additional communications about flood risks and adaptation strategies.

  18. Pittsburgh and the Arts or How My Eye Was Formed.

    ERIC Educational Resources Information Center

    Roschwalb, Susanne A.

    The way the author's experiences of the city of Pittsburgh (Pennsylvania) shaped her visual literacy are explored. Along with the imagery of the steel mills, she experienced some artistic opportunities that helped shape the foundation of her life in art. Although no American city was as extensively industrialized as Pittsburgh, it was the artistic…

  19. Detection of isolated cerebrovascular beta-amyloid with Pittsburgh compound B.

    PubMed

    Greenberg, Steven M; Grabowski, Thomas; Gurol, M Edip; Skehan, Maureen E; Nandigam, R N Kaveer; Becker, John A; Garcia-Alloza, Monica; Prada, Claudia; Frosch, Matthew P; Rosand, Jonathan; Viswanathan, Anand; Smith, Eric E; Johnson, Keith A

    2008-11-01

    Imaging of cerebrovascular beta-amyloid (cerebral amyloid angiopathy) is complicated by the nearly universal overlap of this pathology with Alzheimer's pathology. We performed positron emission tomographic imaging with Pittsburgh Compound B on 42-year-old man with early manifestations of Iowa-type hereditary cerebral amyloid angiopathy, a form of the disorder with little or no plaque deposits of fibrillar beta-amyloid. The results demonstrated increased Pittsburgh Compound B retention selectively in occipital cortex, sparing regions typically labeled in Alzheimer's disease. These results offer compelling evidence that Pittsburgh Compound B positron emission tomography can noninvasively detect isolated cerebral amyloid angiopathy before overt signs of tissue damage such as hemorrhage or white matter lesions.

  20. Municipal Fleet Vehicle Electrification and Photovoltaic Power In the City of Pittsburgh.

    DOT National Transportation Integrated Search

    2016-01-01

    This document reports the results of a cost benefit analysis on potential photovoltaic projects : in Pittsburgh and electrifying the citys light duty civilian vehicle fleet. Currently the : city of Pittsburgh has a civilian passenger vehicle fleet...

  1. Pathology informatics questions and answers from the University of Pittsburgh pathology residency informatics rotation.

    PubMed

    Harrison, James H

    2004-01-01

    Effective pathology practice increasingly requires familiarity with concepts in medical informatics that may cover a broad range of topics, for example, traditional clinical information systems, desktop and Internet computer applications, and effective protocols for computer security. To address this need, the University of Pittsburgh (Pittsburgh, Pa) includes a full-time, 3-week rotation in pathology informatics as a required component of pathology residency training. To teach pathology residents general informatics concepts important in pathology practice. We assess the efficacy of the rotation in communicating these concepts using a short-answer examination administered at the end of the rotation. Because the increasing use of computers and the Internet in education and general communications prior to residency training has the potential to communicate key concepts that might not need additional coverage in the rotation, we have also evaluated incoming residents' informatics knowledge using a similar pretest. This article lists 128 questions that cover a range of topics in pathology informatics at a level appropriate for residency training. These questions were used for pretests and posttests in the pathology informatics rotation in the Pathology Residency Program at the University of Pittsburgh for the years 2000 through 2002. With slight modification, the questions are organized here into 15 topic categories within pathology informatics. The answers provided are brief and are meant to orient the reader to the question and suggest the level of detail appropriate in an answer from a pathology resident. A previously published evaluation of the test results revealed that pretest scores did not increase during the 3-year evaluation period, and self-assessed computer skill level correlated with pretest scores, but all pretest scores were low. Posttest scores increased substantially, and posttest scores did not correlate with the self-assessed computer skill level

  2. Prevalence of Clostridium difficile in uncooked ground meat products from Pittsburgh, Pennsylvania.

    PubMed

    Curry, Scott R; Marsh, Jane W; Schlackman, Jessica L; Harrison, Lee H

    2012-06-01

    The prevalence of Clostridium difficile in retail meat samples has varied widely. The food supply may be a source for C. difficile infections. A total of 102 ground meat and sausage samples from 3 grocers in Pittsburgh, PA, were cultured for C. difficile. Brand A pork sausages were resampled between May 2011 and January 2012. Two out of 102 (2.0%) meat products initially sampled were positive for C. difficile; both were pork sausage from brand A from the same processing facility (facility A). On subsequent sampling of brand A products, 10/19 samples from processing facility A and 1/10 samples from 3 other facilities were positive for C. difficile. The isolates recovered were inferred ribotype 078, comprising 6 genotypes. The prevalence of C. difficile in retail meat may not be as high as previously reported in North America. When contamination occurs, it may be related to events at processing facilities.

  3. The Impact of The University of Pittsburgh on the Local Economy.

    ERIC Educational Resources Information Center

    Pittsburgh Univ., PA. University Urban Interface Program.

    One of the projects selected for the University Urban Interface Program at the University of Pittsburgh was that of studying the impact of the university on the city of Pittsburgh. In pursuing this goal, studies were made of university-related local business volume; value of local business property committed to university-related business; credit…

  4. NARSTO EPA SS PITTSBURGH GAS PM PROPERTY DATA

    Atmospheric Science Data Center

    2018-04-09

    ... Sizer Nephelometer Aerosol Collector SMPS - Scanning Mobility Particle Sizer Fluorescence Spectroscopy ... Get Google Earth Related Data:  Environmental Protection Agency Supersites Pittsburgh, Pennsylvania ...

  5. The Pulse of Allegheny County and Pittsburgh.

    DOT National Transportation Integrated Search

    2016-01-01

    Cities are increasingly equipped with low-resolution cameras. They are cheap to : buy, install, and maintain, and thus are usually the choice of departments of : transportation and their contractors. Pittsburgh or New York City have networks of : hun...

  6. City of Pittsburgh 2012 Technical Assistance Project Documents

    EPA Pesticide Factsheets

    Each report describes a design for a section of the City of Pittsburgh that was chosen in partnership with 3 Rivers Wet Wet Weather to address stormwater management and provide other green infrastructure benefits.

  7. Training in pathology informatics: implementation at the University of Pittsburgh.

    PubMed

    Harrison, James H; Stewart, Jimmie

    2003-08-01

    Pathology informatics is generally recognized as an important component of pathology training, but the scope, form, and goals of informatics training vary substantially between pathology residency programs. The Training and Education Committee of the Association for Pathology Informatics (API TEC) has developed a standard set of knowledge and skills objectives that are recommended for inclusion in pathology informatics training and may serve to standardize and formalize training programs in this area. The University of Pittsburgh (Pittsburgh, Pa) core rotation in pathology informatics includes most of these goals and is offered as an implementation model for pathology informatics training. The core rotation in pathology informatics is a 3-week, full-time rotation including didactic sessions and hands-on laboratories. Topics include general desktop computing and the Internet, but the primary focus of the rotation is vocabulary and concepts related to enterprise and pathology information systems, pathology practice, and research. The total contact time is 63 hours, and a total of 19 faculty and staff contribute. Pretests and posttests are given at the start and end of the rotation. Performance and course evaluation data were collected for 3 years (a total of 21 residents). The rotation implements 84% of the knowledge objectives and 94% of the skills objectives recommended by the API TEC. Residents scored an average of about 20% on the pretest and about 70% on the posttest for an average increase during the course of 50%. Posttest scores did not correlate with pretest scores or self-assessed computer skill level. The size of the pretest/posttest difference correlated negatively with the pretest scores and self-assessed computing skill level. Pretest scores were generally low regardless of whether residents were familiar with desktop computing and productivity applications, indicating that even residents who are computer "savvy" have limited knowledge of pathology

  8. Creating a Methodology for Coordinating High-resolution Air Quality Improvement Map and Greenhouse Gas Mitigation Strategies in Pittsburgh City

    NASA Astrophysics Data System (ADS)

    Shi, J.; Donahue, N. M.; Klima, K.; Blackhurst, M.

    2016-12-01

    In order to tradeoff global impacts of greenhouse gases with highly local impacts of conventional air pollution, researchers require a method to compare global and regional impacts. Unfortunately, we are not aware of a method that allows these to be compared, "apples-to-apples". In this research we propose a three-step model to compare possible city-wide actions to reduce greenhouse gases and conventional air pollutants. We focus on Pittsburgh, PA, a city with consistently poor air quality that is interested in reducing both greenhouse gases and conventional air pollutants. First, we use the 2013 Pittsburgh Greenhouse Gas Inventory to update the Blackhurst et al. model and conduct a greenhouse gas abatement potentials and implementation costs of proposed greenhouse gas reduction efforts. Second, we use field tests for PM2.5, NOx, SOx, organic carbon (OC) and elemental carbon (EC) data to inform a Land-use Regression Model for local air pollution at a 100m x 100m spatial level, which combined with a social cost of air pollution model (EASIUR) allows us to calculate economic social damages. Third, we combine these two models into a three-dimensional greenhouse gas cost abatement curve to understand the implementation costs and social benefits in terms of air quality improvement and greenhouse gas abatement for each potential intervention. We anticipated such results could provide policy-maker insights in green city development.

  9. Can the Ottawa and Pittsburgh rules reduce requests for radiography in patients referred to acute knee clinics?

    PubMed Central

    Zang, TT; Tamimi, N; Haddad, FS

    2013-01-01

    Our aim was to study the role of the Ottawa and Pittsburgh rules to reduce the unnecessary use of radiographs following knee injury. We prospectively reviewed 106 patients who were referred to our clinic over a 3-month period. The Ottawa and Pittsburgh rules were applied to individual patients to evaluate the need for radiography. One hundred and one patients (95%) had radiography of their knee. Five patients (5%) had a fracture of their knee and in all cases, the Ottawa and Pittsburgh knee rules were fulfilled. Using the Ottawa rules, 27 radiographs (25%) could have been avoided without missing a fracture. Using the Pittsburgh rules, 32 radiographs (30%) could have been avoided. The Ottawa and Pittsburgh rules have a high sensitivity for the detection of knee fractures. Their use can aid efficient clinical evaluation without adverse clinical outcome and may reduce healthcare costs. PMID:23827289

  10. Can the Ottawa and Pittsburgh rules reduce requests for radiography in patients referred to acute knee clinics?

    PubMed

    Konan, S; Zang, T T; Tamimi, N; Haddad, F S

    2013-04-01

    Our aim was to study the role of the Ottawa and Pittsburgh rules to reduce the unnecessary use of radiographs following knee injury. We prospectively reviewed 106 patients who were referred to our clinic over a 3-month period. The Ottawa and Pittsburgh rules were applied to individual patients to evaluate the need for radiography. One hundred and one patients (95%) had radiography of their knee. Five patients (5%) had a fracture of their knee and in all cases, the Ottawa and Pittsburgh knee rules were fulfilled. Using the Ottawa rules, 27 radiographs (25%) could have been avoided without missing a fracture. Using the Pittsburgh rules, 32 radiographs (30%) could have been avoided. The Ottawa and Pittsburgh rules have a high sensitivity for the detection of knee fractures. Their use can aid efficient clinical evaluation without adverse clinical outcome and may reduce healthcare costs.

  11. Improving School Leadership through Support, Evaluation, and Incentives: The Pittsburgh Principal Incentive Program. Monograph

    ERIC Educational Resources Information Center

    Hamilton, Laura S.; Engberg, John; Steiner, Elizabeth D.; Nelson, Catherine Awsumb; Yuan, Kun

    2012-01-01

    In 2007, the Pittsburgh Public Schools (PPS) received funding from the U.S. Department of Education's Teacher Incentive Fund (TIF) program to implement the Pittsburgh Urban Leadership System for Excellence (PULSE), a set of reforms designed to improve the quality of school leadership throughout the district. A major component of PULSE is the…

  12. Estimating Teacher and School Effectiveness in Pittsburgh: Value-Added Modeling and Results. Final Report

    ERIC Educational Resources Information Center

    Lipscomb, Stephen; Gill, Brian; Booker, Kevin; Johnson, Matthew

    2010-01-01

    At the request of Pittsburgh Public Schools (PPS) and the Pittsburgh Federation of Teachers (PFT), Mathematica is developing value-added models (VAMs) that aim to estimate the contributions of individual teachers, teams of teachers, and schools to the achievement growth of their students. The analyses described in this report are intended as an…

  13. A Small, For-Profit College Unnerves Pittsburgh Academics.

    ERIC Educational Resources Information Center

    Borrego, Anne Marie

    2001-01-01

    Explores how Pittsburgh's traditional colleges did not fight the for-profit University of Phoenix when it arrived, but are now going after a tiny for-profit institution, Potomac College, that wants to expand into the area. The colleges claim the school unnecessarily duplicates offerings they provide. (EV)

  14. Semi-Supervised Multiple Feature Analysis for Action Recognition

    DTIC Science & Technology

    2013-11-26

    Technology and Electrical Engineering, University of Queensland, Brisbane, Australia ( e -mail: sen.wang@uq.edu.au; yi.yang@uq.edu.au). Z. Ma is with...the Language Technologies Institute, Carnegie Mellon Univer- sity, Pittsburgh, PA 15213 USA ( e -mail: kevinma@cs.cmu.edu). X. Li is with the School of...Service Computing in Cyber Physical Society, Chongqing University, Chongqing, China ( e -mail: xueli@itee.uq.edu.au). C. Pang is with the Australian e

  15. Preparing for local adaptation: Understanding flood risk perceptions in Pittsburgh

    NASA Astrophysics Data System (ADS)

    Wong-Parodi, G.; Klima, K.

    2016-12-01

    In cities such as Pittsburgh, aging and insufficient infrastructure contributes to flashfloods and numerous combined sewer overflows annually, contaminating streets, basements and waterways. Climate change is expected to further exacerbate this problem by causing more intense and more frequent extreme events in Western Pennsylvania. For a storm water adaptation plan to be implemented successfully, the City of Pittsburgh will need informed public support. One way to achieve public understanding and support is through effective communication of the risks, benefits, and uncertainties of local flooding hazards and adaptation methods. In order to develop risk communications effectively, the City and its partners will need to know what knowledge and attitudes the residents of Pittsburgh already hold about flood risks. To that end we surveyed 1,376 Pittsburgh residents on a variety of flood risk topics through an online or paper survey in Fall 2015. On balance, residents were relatively knowledgeable about storm water and see the City's current infrastructure as being inadequate to meet future risk. Moreover, they see the risk of runoff events as increasing and especially among those who live in hazardous flood areas. Residents expressed interest in having a dedicated fund to deal with runoff events. Among those queried about their willingness-to-pay, those asked to pay $15 were most interested in a dedicated fund and for green infrastructure (as opposed to gray infrastructure) in particular. Finally, while most residents favored green infrastructure in terms of its attractiveness and perceived affects on mitigating climate change many did not see it as effective at addressing flooding as gray infrastructure. We found people understand the risk and are open to doing something about it. However, more guidance and information on appropriate ways to adapt locally in terms that make sense to residents could enhance informed support for adaptation measures.

  16. Perspectives on Art Therapy: The Proceedings of the Pittsburgh Conference on Art Therapy (2nd, Pittsburgh, Pennsylvania, May 20, 1977).

    ERIC Educational Resources Information Center

    Roth, Ellen A., Ed.; Rubin, Judith A., Ed.

    The proceedings of the 2nd annual Pittsburgh Conference on Art Therapy (with handicapped persons) consists of 44 items including full length papers, summaries of previously published papers, descriptions of workshops, and a limited number of abstracts (submitted by those who chose not to present a paper or workshop description). The papers are…

  17. Alternative Fuels Data Center: Pittsburgh Livery Company Transports

    Science.gov Websites

    Customers in Alternative Fuel VehiclesA> Pittsburgh Livery Company Transports Customers in hybrid, propane, and natural gas vehicles to transport customers. For information about this project Television Related Videos Photo of a car Electric Vehicles Charge up at State Parks in West Virginia Dec. 9

  18. Forging a New Partnership: The Story of Teacher Union and School District Collaboration in Pittsburgh

    ERIC Educational Resources Information Center

    Hamill, Sean D.

    2011-01-01

    This paper documents Pittsburgh's transformation from a typical, adversarial district-union dynamic to one of deep, substantive collaboration over the course of several years. This work has catapulted Pittsburgh to the vanguard of efforts to improve teacher effectiveness, and helped secure more than $80 million in philanthropic and federal grants.…

  19. A Discussion of the Pittsburgh Reading Conference Papers.

    ERIC Educational Resources Information Center

    Samuels, S. J.

    Reviews and evaluative comments concerning the 11 papers read during the April 1976 portion of the Pittsburgh conference on the theory and practice of beginning reading are included in this document. Before the papers are reviewed, information is presented on some questions posed at the conference within the context of two issues that were raised…

  20. The Pittsburgh Girls Study: Overview and Initial Findings

    ERIC Educational Resources Information Center

    Keenan, Kate; Hipwell, Alison; Chung, Tammy; Stepp, Stephanie; Stouthamer-Loeber, Magda; Loeber, Rolf; McTigue, Kathleen

    2010-01-01

    The Pittsburgh Girls Study is a longitudinal, community-based study of 2,451 girls who were initially recruited when they were between the ages of 5 and 8 years. The primary aim of the study was testing developmental models of conduct disorder, major depressive disorder, and their co-occurrence in girls. In the current article, we summarize the…

  1. Carbon-11-Pittsburgh compound B positron emission tomography imaging of amyloid deposition in presenilin 1 mutation carriers.

    PubMed

    Knight, William D; Okello, Aren A; Ryan, Natalie S; Turkheimer, Federico E; Rodríguez Martinez de Llano, Sofia; Edison, Paul; Douglas, Jane; Fox, Nick C; Brooks, David J; Rossor, Martin N

    2011-01-01

    (11)Carbon-Pittsburgh compound B positron emission tomography studies have suggested early and prominent amyloid deposition in the striatum in presenilin 1 mutation carriers. This cross-sectional study examines the (11)Carbon-Pittsburgh compound B positron emission tomography imaging profiles of presymptomatic and mildly affected (mini-mental state examination ≥ 20) carriers of seven presenilin 1 mutations, comparing them with groups of controls and symptomatic sporadic Alzheimer's disease cases. Parametric ratio images representing (11)Carbon-Pittsburgh compound B retention from 60 to 90 min were created using the pons as a reference region and nine regions of interest were studied. We confirmed that increased amyloid load may be detected in presymptomatic presenilin 1 mutation carriers with (11)Carbon-Pittsburgh compound B positron emission tomography and that the pattern of retention is heterogeneous. Comparison of presenilin 1 and sporadic Alzheimer's disease groups revealed significantly greater thalamic retention in the presenilin 1 group and significantly greater frontotemporal retention in the sporadic Alzheimer's disease group. A few individuals with presenilin 1 mutations showed increased cerebellar (11)Carbon-Pittsburgh compound B retention suggesting that this region may not be as suitable a reference region in familial Alzheimer's disease.

  2. Abstracts of Papers Presented at the 2005 Pittsburgh Conference

    PubMed Central

    Stockwell, Peter B.

    2005-01-01

    To attend or not to attend, that is the question. The Pittsburgh Conference continues to pose this conundrum to conferees and exhibitors alike. This year's conference was the first to be presented without a set of paper abstracts—a good thing some would say but this old codger always used the paper abstracts to select papers of interest to our readership and to seek a full publication. The exhibit took its usual format but it seemed that there were less manufacturers present. The information presented to the attendees was also lacking and many companies' details were missing from the final program book, an omission no doubt on their behalf—my company was one of these—however I feel sure that past Pittcon organizers would have been more persistent in getting the required details for the audience. As is now the norm, many of the presentations take the form of posters displayed within the exhibition area. Without a driver to get the audience there, the traffic was slow, to say the least. Lecture presentations were also attended in a mixed fashion. So the Pittsburgh Conference show moves on, and again next year it will be held in Orlando from 12 March to 17 March 2006. No doubt I will be there making it a straight 31 in a row; in Pittsburgh Conference terms I am just a beginner with many of the attendees making more shows in a run than that. Selected abstracts dealing with topics of interest to the readers of this journal follow—hopefully many of these groups will be willing to publish their work either within this journal or elsewhere. PMID:18924631

  3. Abstracts of papers presented at the 2005 pittsburgh conference.

    PubMed

    Stockwell, Peter B

    2005-01-01

    To attend or not to attend, that is the question. The Pittsburgh Conference continues to pose this conundrum to conferees and exhibitors alike. This year's conference was the first to be presented without a set of paper abstracts-a good thing some would say but this old codger always used the paper abstracts to select papers of interest to our readership and to seek a full publication. The exhibit took its usual format but it seemed that there were less manufacturers present. The information presented to the attendees was also lacking and many companies' details were missing from the final program book, an omission no doubt on their behalf-my company was one of these-however I feel sure that past Pittcon organizers would have been more persistent in getting the required details for the audience. As is now the norm, many of the presentations take the form of posters displayed within the exhibition area. Without a driver to get the audience there, the traffic was slow, to say the least. Lecture presentations were also attended in a mixed fashion. So the Pittsburgh Conference show moves on, and again next year it will be held in Orlando from 12 March to 17 March 2006. No doubt I will be there making it a straight 31 in a row; in Pittsburgh Conference terms I am just a beginner with many of the attendees making more shows in a run than that. Selected abstracts dealing with topics of interest to the readers of this journal follow-hopefully many of these groups will be willing to publish their work either within this journal or elsewhere.

  4. Air Quality from Early Pittsburgh to the Present: The Science of Change

    NASA Astrophysics Data System (ADS)

    Davidson, Cliff

    2009-03-01

    Throughout Pittsburgh's history over the past 250 years, coal reserves in the city and nearby have influenced its economy, demographics, and environmental quality. They have also played a major role in determining air quality in the region. For example, Pittsburgh became famous for its high particle loadings as early as the beginning of the nineteenth century, when the first complaints about air quality in the city were recorded. Nevertheless, residents tolerated the high coal smoke levels since jobs depended on the iron works, steel mills, and other industries. When natural gas was discovered just east of the city in the 1870's and replaced coal for some applications, particle concentrations decreased. But the local supplies of natural gas ran short several years later, and as industry continued to expand in the 1890's the city went back to the use of coal as its primary fuel. The return to smoky air was met with resistance that marked the beginning of sustained public outcry and initiation of several air pollution studies. The next half century was marked by periods of occasional high and low concentration, the latter due to events such as the financial panic of 1907 and the depression of the 1930's. It was not until the 1940's that effective regulations were passed to reduce smoky conditions. Particle levels fell throughout the 1950's and 1960's, and eventually the decline of heavy industry in Pittsburgh led to relatively clean air in many parts of the city. Over the past few decades, airborne particle concentrations averaged across the Pittsburgh region have remained below their earlier levels. However, there are still ``hot spots'' of high concentration resulting from regional background coming from upwind areas and emissions of some large sources that have continued to operate in the Pittsburgh region. Furthermore, the composition of airborne particles in the city has changed from earlier times. Such particles are now the result of emissions from sources in

  5. An Evaluation of the Pittsburgh Reading is FUNdamental Program.

    ERIC Educational Resources Information Center

    Boldovici, John A.; And Others

    A study of one of the model "Reading is FUNdamental" (RIF) programs located in Pittsburgh, Pennsylvania, was made to determine the success of the program and to formulate suggestions for changes. RIF is a program in which free or inexpensive books are made available in a community through schools, libraries, and other local organizations…

  6. The upper pennsylvanian pittsburgh coal bed: Resources and mine models

    USGS Publications Warehouse

    Watson, W.D.; Ruppert, L.F.; Tewalt, S.J.; Bragg, L.J.

    2001-01-01

    The U.S. Geological Survey recently completed a digital coal resource assessment model of the Upper Pennsylvanian Pittsburgh coal bed, which indicates that after subtracting minedout coal, 16 billion short tons (14 billion tonnes) remain of the original 34 billion short tons (31 billion tonnes) of coal. When technical, environmental, and social restrictions are applied to the remaining Pittsburgh coal model, only 12 billion short tons (11 billion tonnes) are available for mining. Our assessment models estimate that up to 0.61 billion short tons (0.55 billion tonnes), 2.7 billion short tons (2.4 billion tonnes), and 8.5 billion short tons (7.7 billion tonnes) could be available for surface mining, continuous mining, and longwall mining, respectively. This analysis is an example of a second-generation regional coal availability study designed to model recoverability characteristics for all the major coal beds in the United States. ?? 2001 International Association for Mathematical Geology.

  7. Mental Health Services in the Pittsburgh Public Schools; 1967-1968.

    ERIC Educational Resources Information Center

    Richman, Vivien

    The 1967-68 mental health services (MHS) program in the Pittsburgh public school system, number of children served, studies undertaken, and other staff activities are considered. A research study of perceptual-motor dysfunction among emotionally disturbed, educable mentally handicapped, and normal children, and two perceptual surveys developed for…

  8. Pest status of the brown marmorated stink bug, Halyomorpha halys (Stal) in the USA

    USDA-ARS?s Scientific Manuscript database

    Since its initial discovery in Allentown, PA, USA, the brown marmorated stink bug (BMSB), Halyomorpha halys (Heteroptera: Pentatomidae), has now officially been detected in 37 states and the District of Columbia in the USA. Isolated populations also exist in Switzerland and Canada. This Asian spec...

  9. University Urban Interface Study. The Pittsburgh Goals Study: A Summary.

    ERIC Educational Resources Information Center

    Nehnevajsa, Jiri; Coleman, Alan N.

    The main purpose of this study was to determine the extent to which community consensus existed regarding a variety of major changes in Pittsburgh and the extent to which widely differing perspectives of community leaders might contribute to conflict, or at least significant difficulties, on these issues. A pragmatic secondary objective was to…

  10. Truth, Love and Campus Expansion. The University of Pittsburgh Experience.

    ERIC Educational Resources Information Center

    Shaw, Paul C.

    This document provides a descriptive analysis of the University of Pittsburgh's experience with campus expansion during a 2 1/2 year period from fall 1970 to spring 1973. Part one describes a background and overview of campus expansion, a description of selective Oakland demographic characteristics, a discussion of the first major conflict with…

  11. Sexism in Textbooks in Pittsburgh Public Schools, Grades K-5.

    ERIC Educational Resources Information Center

    Scardina, Florence

    Thirty-six textbooks used by the Pittsburgh public schools at grade levels K-5 were reviewed to see how they treat girls vs. boys and men vs. women. Language, reading, science, social studies, and mathematics texts were evaluated. Blatant sexism is found in all areas. Different ideas of behavior and mores are propagated for boys than for girls;…

  12. PaR-PaR Laboratory Automation Platform

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Linshiz, G; Stawski, N; Poust, S

    2013-05-01

    Labor-intensive multistep biological tasks, such as the construction and cloning of DNA molecules, are prime candidates for laboratory automation. Flexible and biology-friendly operation of robotic equipment is key to its successful integration in biological laboratories, and the efforts required to operate a robot must be much smaller than the alternative manual lab work. To achieve these goals, a simple high-level biology-friendly robot programming language is needed. We have developed and experimentally validated such a language: Programming a Robot (PaR-PaR). The syntax and compiler for the language are based on computer science principles and a deep understanding of biological workflows. PaR-PaRmore » allows researchers to use liquid-handling robots effectively, enabling experiments that would not have been considered previously. After minimal training, a biologist can independently write complicated protocols for a robot within an hour. Adoption of PaR-PaR as a standard cross-platform language would enable hand-written or software-generated robotic protocols to be shared across laboratories.« less

  13. PaR-PaR laboratory automation platform.

    PubMed

    Linshiz, Gregory; Stawski, Nina; Poust, Sean; Bi, Changhao; Keasling, Jay D; Hillson, Nathan J

    2013-05-17

    Labor-intensive multistep biological tasks, such as the construction and cloning of DNA molecules, are prime candidates for laboratory automation. Flexible and biology-friendly operation of robotic equipment is key to its successful integration in biological laboratories, and the efforts required to operate a robot must be much smaller than the alternative manual lab work. To achieve these goals, a simple high-level biology-friendly robot programming language is needed. We have developed and experimentally validated such a language: Programming a Robot (PaR-PaR). The syntax and compiler for the language are based on computer science principles and a deep understanding of biological workflows. PaR-PaR allows researchers to use liquid-handling robots effectively, enabling experiments that would not have been considered previously. After minimal training, a biologist can independently write complicated protocols for a robot within an hour. Adoption of PaR-PaR as a standard cross-platform language would enable hand-written or software-generated robotic protocols to be shared across laboratories.

  14. Water resources of the Pittsburgh area, Pennsylvania

    USGS Publications Warehouse

    Noecker, Max; Greenman, D.W.; Beamer, N.H.

    1954-01-01

    The per capita use of water in the Pittsburgh area in 1951 was 2, 000 gallons per day fgpd) or twice the per capita use in Pennsylvania as a whole. An average of about 3, 040 million gallons of water was withdrawn from the streams and from the ground each day. Of this amount, nearly 190 million gallons per day (mgd), or 6 percent, was for domestic public water supply. Industry, including public utilities generating steam for electric energy, used approximately 2, 900 mgd, of which about 42 mgd was purchased from public supply sources. In spite of this tremendous demand for water, a sufficient quantity was available to satisfy the needs of the area without serious difficulty. Acid mine drainage presents the greatest single pollution problem in the Pittsburgh area at the present time (1953) because no practical means has been found for its control. The waters of several of the rivers are strongly acid for this reason. Of the three major rivers in the area, Monongahela River waters have the greatest acid concentration and Allegheny River waters the least. Untreated domestic and industrial wastes are additional sources of stream pollution in the area. Much of the water is hard and corrosive, and occasionally has objectionable color, odor, and taste. The treatment used by public water-supply systems using river water is adequate at all times for removal of water-borne causes of disease. Attention is being concentrated on improving the quality of present supplies rather than developing new supplies from upstream tributaries. Present supplies are being improved by providing treatment facilities for disposal of wastes,, by reduction of acid mine drainage discharged into the streams, and by providing storage to augment low flows. The underground water resources are vitally important to the area. The use of ground water in the Pittsburgh area has doubled in the past two decades and in 1951 more ground water was used in Allegheny County than in any other county in

  15. EnviroAtlas - Pittsburgh, PA - Near Road Tree Buffer

    EPA Pesticide Factsheets

    This EnviroAtlas dataset addresses the tree buffer along heavily traveled roads. The roads are interstates, arterials, and collectors within the EnviroAtlas community boundary. Forest is defined as Trees & Forest. Sufficient tree bufferage is defined as 25% coverage within the circular moving window with a radius of 14.5m at any given point along the roadway. There are potential negative health effects for those living in a location without a sufficient tree buffer. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

  16. A Precarious Ecstasy: Beyond Temporality in Self and Other

    ERIC Educational Resources Information Center

    Nolan, Greg

    2016-01-01

    This article explores Levinas's [1961/1969. "Totality and infinity." (A. Lingis, Trans.). Pittsburgh, PA: Duquesne University Press; 1981/1997. "Otherwise than being or beyond essence." (A. Lingis, Trans.). Pittsburgh, PA: Duquesne University Press] ideas on relational proximity in the face of the Other and, through meeting,…

  17. THE PITTSBURGH AIR POLLUTION EPISODE OF NOVEMBER 17-21 1975: AIR QUALITY

    EPA Science Inventory

    In November 1975 a serious air stagnation problem developed over Western Pennsylvania, with extremely heavy air pollution in the Pittsburgh area. The U.S. Environmental Protection Agency's Health Effects Research Laboratory (HERL) mobilized a team of air monitoring and epidemiolo...

  18. Elements related to attrition of women faculty at the University of Pittsburgh, School of Medicine: A case study

    NASA Astrophysics Data System (ADS)

    Gandhi, Pooja

    Recent studies have shown that the number of women faculty in academic medicine is much lesser than the number of women that are graduating from medical schools. Many academic institutes face the challenge of retaining talented faculty and this attrition from academic medicine prevents career advancement of women faculty. This case study attempts to identify some of the reasons for dissatisfaction that may be related to the attrition of women medical faculty at the University of Pittsburgh, School of Medicine. Data was collected using a job satisfaction survey, which consisted of various constructs that are part of a faculty's job and proxy measures to gather the faculty's intent to leave their current position at the University of Pittsburgh or academic medicine in general. The survey results showed that although women faculty were satisfied with their job at the University of Pittsburgh, there are some important factors that influenced their decision of potentially dropping out. The main reasons cited by the women faculty were related to funding pressures, work-life balance, mentoring of junior faculty and the amount of time spent on clinical responsibilities. The analysis of proxy measures showed that if women faculty decided to leave University of Pittsburgh, it would most probably be due to better opportunity elsewhere followed by pressure to get funding. The results of this study aim to provide the School of Medicine at the University of Pittsburgh with information related to attrition of its women faculty and provide suggestions for implications for policy to retain their women faculty.

  19. Clinicopathologic and 11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer’s disease spectrum

    PubMed Central

    Lowe, Val J.; Graff-Radford, Neill R.; Liesinger, Amanda M.; Cannon, Ashley; Przybelski, Scott A.; Rawal, Bhupendra; Parisi, Joseph E.; Petersen, Ronald C.; Kantarci, Kejal; Ross, Owen A.; Duara, Ranjan; Knopman, David S.; Jack, Clifford R.; Dickson, Dennis W.

    2015-01-01

    Thal amyloid phase, which describes the pattern of progressive amyloid-β plaque deposition in Alzheimer’s disease, was incorporated into the latest National Institute of Ageing – Alzheimer’s Association neuropathologic assessment guidelines. Amyloid biomarkers (positron emission tomography and cerebrospinal fluid) were included in clinical diagnostic guidelines for Alzheimer’s disease dementia published by the National Institute of Ageing – Alzheimer’s Association and the International Work group. Our first goal was to evaluate the correspondence of Thal amyloid phase to Braak tangle stage and ante-mortem clinical characteristics in a large autopsy cohort. Second, we examined the relevance of Thal amyloid phase in a prospectively-followed autopsied cohort who underwent ante-mortem 11C-Pittsburgh compound B imaging; using the large autopsy cohort to broaden our perspective of 11C-Pittsburgh compound B results. The Mayo Clinic Jacksonville Brain Bank case series (n = 3618) was selected regardless of ante-mortem clinical diagnosis and neuropathologic co-morbidities, and all assigned Thal amyloid phase and Braak tangle stage using thioflavin-S fluorescent microscopy. 11C-Pittsburgh compound B studies from Mayo Clinic Rochester were available for 35 participants scanned within 2 years of death. Cortical 11C-Pittsburgh compound B values were calculated as a standard uptake value ratio normalized to cerebellum grey/white matter. In the high likelihood Alzheimer’s disease brain bank cohort (n = 1375), cases with lower Thal amyloid phases were older at death, had a lower Braak tangle stage, and were less frequently APOE-ε4 positive. Regression modelling in these Alzheimer’s disease cases, showed that Braak tangle stage, but not Thal amyloid phase predicted age at onset, disease duration, and final Mini-Mental State Examination score. In contrast, Thal amyloid phase, but not Braak tangle stage or cerebral amyloid angiopathy predicted 11C-Pittsburgh compound

  20. 77 FR 50012 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-20

    ..., Amdt 2 Oklahoma City, OK, Will Rogers World, Takeoff Minimums and Obstacle DP, Amdt 1 Portland, OR... CLOSE PARALLEL), Amdt 4, CANCELED Philadelphia, PA, Philadelphia Intl, ILS PRM RWY 27L (SIMULTANEOUS CLOSE PARALLEL), Amdt 3, CANCELED Pittsburgh, PA, Allegheny County, ILS OR LOC RWY 10, Amdt 6 Pittsburgh...

  1. The Pittsburgh Sleep Diary

    NASA Technical Reports Server (NTRS)

    Monk, T. H.; Reynolds CF, 3. d.; Kupfer, D. J.; Buysse, D. J.; Coble, P. A.; Hayes, A. J.; Machen, M. A.; Petrie, S. R.; Ritenour, A. M.

    1994-01-01

    Increasingly, there is a need in both research and clinical practice to document and quantify sleep and waking behaviors in a comprehensive manner. The Pittsburgh Sleep Diary (PghSD) is an instrument with separate components to be completed at bedtime and waketime. Bedtime components relate to the events of the day preceding the sleep, waketime components to the sleep period just completed. Two-week PghSD data is presented from 234 different subjects, comprising 96 healthy young middle-aged controls, 37 older men, 44 older women, 29 young adult controls and 28 sleep disorders patients in order to demonstrate the usefulness, validity and reliability of various measures from the instrument. Comparisons are made with polysomnographic and actigraphic sleep measures, as well as personality and circadian type questionnaires. The instrument was shown to have sensitivity in detecting differences due to weekends, age, gender, personality and circadian type, and validity in agreeing with actigraphic estimates of sleep timing and quality. Over a 12-31 month delay, PghSD measures of both sleep timing and sleep quality showed correlations between 0.56 and 0.81 (n = 39, P < 0.001).

  2. Coalbed gas potential in the Pittsburgh-Huntington synclinorium, northern West Virginia

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Patchen, D.G.; Schwietering, J.F.; Repine, T.E.

    1991-03-01

    The West Virginia Geological and Economic Survey (WVGES) received a subcontract from the Texas Bureau of Economic Geology to conduct a geologic evaluation of critical production parameters for coalbed methane resources in the northern Appalachian coal basin. The study area is a northeast-southwest-trending ellipse that coincides with the axis of the Pittsburgh-Huntington Synclinorium in north central West Virginia and southwestern Pennsylvania. Coalbed gas resources there have been estimated to be 61 bcf in previous work funded by the Gas Research institute. Data used in that study were mainly core descriptions and drillers' logs from coal exploration cores. The current researchmore » will integrate data from the WVGES' coal, oil and gas, and ground water databases to more carefully determine the number and thicknesses of coals below the Pittsburgh, and their hydrologic setting. Main objectives are to determine: the number of coals present; the geographic and stratigraphic positions of the thickest coals; locations of depocenters with stacked coals; the pressure regime of the area and geologic factors contributing to it; ground-water circulation patterns; and the presence of any potentiometric anomalies. Local and regional stratigraphic and structural cross sections and lithofacies and coal occurrence maps will be made for the coal-bearing interval below the Pittsburgh coal to show the distribution, structural attitude, and depositional systems. Regional and local control of structural elements, including fractures, on gas producibility from coalbeds will be determined. Gas and water production data will be collected from two small areas of current production and mapped and compared to maps of geologic parameters. The goal is to measure the effect on production of geologic parameters in these coalbed gas fields, and determine the locations of other 'sweet spots' in these coal beds.« less

  3. Presence of Panulirus argus virus 1 (PaV1) in juvenile spiny lobsters Panulirus argus from the Caribbean coast of Mexico.

    PubMed

    Huchin-Mian, Juan Pablo; Rodríguez-Canul, Rossanna; Arias-Bañuelos, Efrain; Simá-Alvarez, Raúl; Pérez-Vega, Juan A; Briones-Fourzán, Patricia; Lozano-Alvarez, Enrique

    2008-04-01

    Macroscopic evidence, histological sections, transmission electron microscopy (TEM) evaluation, and PCR analyses of 25 apparently diseased juvenile spiny lobsters Panulirus argus from the reef lagoon of Puerto Morelos, Mexico, showed the presence of Panulirus argus Virus 1 (PaV1). Cowdry Type A intranuclear viral inclusions were observed in histological analyses, icosahedral viral particles were observed by TEM, and PCR using specific primers for PaV1 amplified a fragment of 499 bp. This is the first report of PaV1 infecting P. argus outside the Florida Keys, USA.

  4. Lighting retrofits at the Pittsburgh Zoo and Aviary

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sadowski, E.C.

    Energy bills for the Pittsburgh Zoo typically total $280,000 a year, of which about $220,000 are spent on electricity. Until recently, lighting accounted for 20 percent of this electricity use. This translated into an annual cost of $44,000. Recent advances in lighting technology have made it possible to perform lighting retrofits in Zoo facilities that reduce energy costs while also providing improved light quality and better lit and more natural looking exhibits and animal holding areas. Through an investment of $127,690 in these projects from mid-1992 through mid-1994, the Zoo expects to realize an annual savings in electricity costs ofmore » $24,500 and further savings from a reduction in maintenance and plant replacement costs. Retrofits to the lighting systems in the Tropical Forest Building, the Aquarium, and the Niches of the World Building were the most interesting and are described in detail. Providing a sufficient amount of ultraviolet light to maintain the health of reptiles was a particular challenge in the Niches of the World Building. Lack of separate meters and additions to the Zoo have made the determination of the actual performance of these retrofit projects impossible. A similar retrofit project at the Pittsburgh Aviary (now the National Aviary) in 1989 through 1990 provides savings figures that should be comparable to those expected at the Zoo, however. This project cost $100,000 and saved $21,008 in electricity costs during the first year of operation. Maintenance costs were reduced by approximately $5000 a year.« less

  5. Teacher Quality Roadmap: Improving Policies and Practices in Pittsburgh Public Schools

    ERIC Educational Resources Information Center

    Gonzalez, Angel; Kumar, Sudipti; Waymack, Nancy

    2014-01-01

    The Pittsburgh Public Schools study is the 12th district study since the National Council on Teacher Quality (NCTQ) began studying districts in-depth in 2009. The intent of these studies is to give select communities a comprehensive look at what is happening in their local school districts that may be either helping or hurting teacher quality, and…

  6. 77 FR 38271 - Voluntary Termination of Foreign-Trade Subzone 33B Verosol USA, Inc. Kennedy Township, Allegheny...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-27

    ... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [Order No. 1829] Voluntary Termination of Foreign-Trade Subzone 33B Verosol USA, Inc. Kennedy Township, Allegheny County, PA Pursuant to the authority... the establishment of Foreign-Trade Subzone 33B at the Verosol USA, Inc., plant in Kennedy Township...

  7. View of hammer nameplate (Chambersburg Engineering Company, Chambersburg, Penna USA) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of hammer nameplate (Chambersburg Engineering Company, Chambersburg, Penna USA) and view north of Tony Talotta (heavy forger), Paul Azcharka (hammer operator), and Morty Hoffman (hammer operator helper) forging eyebolts. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Structure Shop, League Island, Philadelphia, Philadelphia County, PA

  8. Higher Education Sustainability in Pittsburgh: Highlights from the AASHE 2011 Campus Tours

    ERIC Educational Resources Information Center

    Srinivasamohan, Ashwini; Walton, Judy; Wagner, Margo

    2012-01-01

    This quote by ecologist, "Silent Spring" author and Chatham University alum Rachel Carson reminds us of the everyday tenacity needed in working to advance a sustainable and just world. This publication celebrates that tenacity in the higher education sector, specifically among institutions in the Pittsburgh area. Historically known for…

  9. Partners in Pittsburgh Public Schools' Excellence for All Initiative: Findings from the First Year of Implementation. Documented Briefing. DB-544-FFE

    ERIC Educational Resources Information Center

    Tharp-Taylor, Shannah; Nelson, Catherine Awsumb; Dembosky, Jacob W.; Gill, Brian

    2007-01-01

    The Pittsburgh Public School District asked the RAND Corporation to monitor the first year's implementation (2006-2007) of Excellence for All (EFA) and provide feedback to district staff, the board, and other stakeholders. The Pittsburgh Public School District leadership developed EFA with the aim of increasing student achievement by improving…

  10. Pittsburgh Area Preschool Association Publication: Selected Articles (Volume 8, No. 1-4).

    ERIC Educational Resources Information Center

    Frank, Mary, Ed.

    This compilation of short reports distributed to preschool teachers in the Pittsburgh area covers four main topics: (1) Adoption (2) Expressive Art Therapy, (3) The Infant, and (4) Learning Disorders in Young Children. The adoption section includes reports pertaining to the adoption process in Pennsylvania, adoptive parents' legal rights, medical…

  11. 76 FR 29176 - Airworthiness Directives; Piper Aircraft, Inc. PA-23, PA-31, and PA-42 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-20

    ...-0218; Directorate Identifier 2009-CE-006-AD] RIN 2120-AA64 Airworthiness Directives; Piper Aircraft... (AD) that applies to Piper Aircraft, Inc. PA-23, PA-31, and PA-42 airplanes. The existing AD currently... Federal holidays. For service information identified in this AD, contact Piper Aircraft, Inc., 2926 Piper...

  12. The Power of Place: Social Network Characteristics, Perceived Neighborhood Features, and Psychological Distress Among African Americans in the Historic Hill District in Pittsburgh, Pennsylvania.

    PubMed

    Flórez, Karen R; Ghosh-Dastidar, Madhumita Bonnie; Beckman, Robin; de la Haye, Kayla; Duru, Obidiugwu Kenrik; Abraído-Lanza, Ana F; Dubowitz, Tamara

    2016-09-01

    African American neighborhoods have been historically targeted for urban renewal projects, which impact social composition and resident's health. The Hill District in Pittsburgh, PA is such a neighborhood. This research sought to investigate the extent to which social networks and perceived neighborhood social cohesion and safety were associated with psychological distress among residents in an African American neighborhood undergoing urban renewal, before the implementation of major neighborhood changes. Findings revealed a modest, significant inverse association between social network size and psychological distress (β = -0.006, p < .01), even after controlling for age, employment, education, and income. Perceived neighborhood safety predicted decreased psychological distress (β = -1.438, p < .01), but not social cohesion, which is consistent with past research. Findings suggest that social networks protect against psychological distress, but neighborhood perceptions are also paramount. © Society for Community Research and Action 2016.

  13. Magnetic Field-Induced Phase Transformation in Magnetic Shape Memory Alloys with High Actuation Stress and Work Output

    DTIC Science & Technology

    2010-05-03

    Mechanisms for Advanced Properties in Phase Transforming Materials , Materials Science & Technology 2009 Conference, October 25-29, 2009, Pittsburgh, PA...Advanced Properties in Phase Transforming Materials , Materials Science & Technology 2009 Conference, October 25-29, 2009, Pittsburgh, PA, 2009. 11...observed materials behavior. Indeed, measured materials properties were found not to be the exact indication of the materials real response

  14. The Center on Race and Social Problems at the University of Pittsburgh

    ERIC Educational Resources Information Center

    Davis, Larry E.; Bangs, Ralph L.

    2007-01-01

    In 2002, the School of Social Work at the University of Pittsburgh established the Center on Race and Social Problems (CRSP). CRSP, which is the first race research center to be housed in a school of social work, has six foci: economic disparities; educational disparities; interracial group relations; mental health; youth, families, and elderly;…

  15. Final report on EURAMET.M.P-S12 — Bilateral supplementary comparison of the national pressure standards of CMI and INRIM in the range 300 Pa to 15 kPa of negative gauge pressure

    NASA Astrophysics Data System (ADS)

    Krajícek, Zdenek; Bergoglio, Mercede; Pražák, Dominik; Pasqualin, Stefano

    2014-01-01

    This report describes a EURAMET bilateral supplementary comparison between Czech CMI and Italian INRIM in low negative gauge pressure in gas (nitrogen), denoted as EURAMET.M.P-S12. The digital non-rotating pressure balance FPG8601 manufactured by Fluke/DH-Instruments, USA is normally used for gauge and absolute pressures in the range from 1 Pa to 15 kPa, but with some modifications it can be used also for the negative gauge pressures in the same range. During the preparation of the visit of INRIM at CMI for the last comparison within the framework of EURAMET.M.P-K4.2010, it was agreed to also perform an additional comparison in the range from 300 Pa to 15 kPa of negative gauge pressure. The measurements were performed in October 2012. Both institutes successfully proved their equivalence in all the tested points in the range from 300 Pa to 15 kPa of negative gauge pressure in a comparison that had, so far, been unique. . Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  16. IDENTIFYING A SUSCEPTIBLE SUBGROUP: EFFECTS OF THE PITTSBURGH AIR POLLUTION EPISODE UPON SCHOOL CHILDREN

    EPA Science Inventory

    Pulmonary function test results on 224 parochial schoolchildren collected during and after the Pittsburgh air pollution episode of November 1975 were reanalyzed to determine whether a small subgroup of susceptible children could be defined. Individual regressions of three-quarter...

  17. 78 FR 22843 - Foreign-Trade Zone 33-Pittsburgh, Pennsylvania, Authorization of Export Production Activity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-17

    ..., Pennsylvania, Authorization of Export Production Activity, Tsudis Chocolate Company (Chocolate Confectionery Bars), Pittsburgh, Pennsylvania On December 4, 2012, Tsudis Chocolate Company, submitted a notification... restriction requiring that all foreign-status liquid chocolate admitted to FTZ 33 must be re-exported. Dated...

  18. Changing fuel use behavior: the Pittsburgh smoke control movement, 1940-1950

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tarr, J.A.

    1981-12-01

    Local policy development in Pittsburgh brought about cleaner air by influencing change in the household use of fuel and combustion equipment. By a combination of media campaigns, voluntary organizations, technical advisers, and business and labor leaders, the public was convinced of the necessity to reduce air pollution. The unique aspect is that the public accepted the costs of a long-range policy decision through education and persuasion. 20 refs.

  19. Liver Procurement for Orthotopic Transplantation: An Analysis of the Pittsburgh Experience

    PubMed Central

    Van Thiel, David H.; Schade, Robert R.; Hakala, Thomas R.; Starzl, Thomas E.; Denny, Donald

    2010-01-01

    The incidence of prospective organ donors in the United States and the techniques which are to used to guarantee their optimal use after identification are analyzed. Attitudes of the public and health professionals toward organ donation are discussed. The organization of the Pittsburgh Organ Procurement Agency and its relationship to other such agencies is described. Finally, the presently used techniques of liver salvaging and preservation are outlined. PMID:6363261

  20. Community-acquired Legionella micdadei (Pittsburgh pneumonia agent) infection in Sweden.

    PubMed

    Bäck, E; Schvarcz, R; Kallings, I

    1983-01-01

    The first case of Legionella micdadei (Pittsburgh Pneumonia Agent) infection in Sweden is presented. A previously healthy 68-yr-old man fell ill with diarrhoea, fever, and mental confusion. Subsequently chest roentgenography revealed pneumonic infiltrates and a seroconversion to L. micdadei was shown. No source or transmission of infection was established. The only notable event was that the patient had been drinking rain-water from a barrel 1 day prior to his illness. An alimentary route of infection was considered.

  1. Thermomechanical Transitions in Polyphosphazenes.

    DTIC Science & Technology

    1980-08-08

    ADAOB8 119 PITTSBURGH UNIV PA DEPT OF METALLURGICAL AND MATERI --ETC F/6 11/9 THERMOMECHANICAL TRANSITIONS IN POLYPHOSPHAZENES.(U) AUG B0 I C CHOY, J...Metallurgical and Materials Engr._____ University of Pittsburgh METALLURGICAL AND MATERIALS ENGINEERING University of Pittsburgh Pittsburgh, Pennsylvania...15261 _ _ _ _ ,80 818 05, THERMOMECHANICAL TRANSITIONS IN POLYPHOSPHAZENES I. C. Choy and J. H. Magill Dept. of Metallurgical and Materials Engr

  2. EnviroAtlas - Pittsburgh, PA - Near Road Block Group Summary

    EPA Pesticide Factsheets

    This EnviroAtlas dataset addresses the tree buffer along heavily traveled roads. The roads are interstates, arterials, and collectors within the EnviroAtlas community boundary. Forest is defined as Trees & Forest. Sufficient tree bufferage is defined as 25% coverage within the circular moving window with a radius of 14.5m at any given point along the roadway. There are potential negative health effects for those living in a location without a sufficient tree buffer. Those populations are estimated here using dasymetric data calculated for the EnviroAtlas. There are potential negative health effects for those living in a location without a sufficient tree buffer. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

  3. 75 FR 81469 - Safety Zone; Allegheny River, Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 [Docket No. USCG-2010-1082] RIN 1625... indicated in this preamble as being available in the docket are part of docket USCG-2010-1082 and are available online by going to http://www.regulations.gov , inserting USCG-2010-1082 in the ``Keyword'' box...

  4. THE QUEST FOR RACIAL EQUALITY IN THE PITTSBURGH PUBLIC SCHOOLS. ANNUAL REPORT, 1965.

    ERIC Educational Resources Information Center

    Pittsburgh Board of Public Education, PA.

    THIS REPORT FURNISHES AN ACCOUNT OF THE POLICIES OF THE PITTSBURGH PUBLIC SCHOOLS ON RACIAL INTEGRATION AND EQUALITY OF EDUCATIONAL OPPORTUNITY. PRINCIPLES, PRACTICES, AND PLANS FOR THE FUTURE ARE DETAILED, AND SPECIAL PROBLEM AREAS ARE IDENTIFIED. COMPENSATORY EDUCATION, EVEN IF IT IMPLIES DELAYED INTEGRATION IN SOME INSTANCES, IS SEEN AS THE…

  5. The Use of Research Libraries: A Comment about the Pittsburgh Study and Its Critics.

    ERIC Educational Resources Information Center

    Peat, W. Leslie

    1981-01-01

    Reviews the controversy surrounding the Pittsburgh study of library circulation and collection usage and proposes the use of citation analysis techniques as an acceptable method for measuring research use of a research library which will complement circulation studies. Five references are listed. (RAA)

  6. The Institutional Subordination of Contested Issues: The Case of Pittsburgh's Steelworkers and Ministers.

    ERIC Educational Resources Information Center

    McClure, Kevin R.

    1996-01-01

    Analyzes a case where a group of local steelworkers in the Pittsburgh, Pennsylvania area, in conjunction with a small group of Protestant ministers, sought to gain public support for the redress of grievances, and how their subordination by the United Steel Workers' union and the Lutheran Church influenced their rhetorical activities. (SR)

  7. Report of the NIH Panel to Define Principles of Therapy of HIV Infection and Guidelines for the Use of Antiretroviral Agents in HIV-Infected Adults and Adolescents. Vol. 47/No. RR-5.

    DTIC Science & Technology

    1998-04-25

    MA David Cooper, M.D. National Center for HIV Epidemiology and Clinical Research Sydney, NSW, Australia Stephen Follansbee, M.D. Davies...National Association of People with AIDS Washington, DC David Barr, J.D. Forum for Collaborative HIV Research Washington, DC Samuel Bozzette, M.D...Mellors, M.D. University of Pittsburgh Pittsburgh, PA David Nash, M.D. Thomas Jefferson University Philadelphia, PA Sallie Perryman New York

  8. Ex Vivo Machine Perfusion in CTA with a Novel Oxygen Carrier System to Enhance Graft Preservation and Immunologic Outcomes

    DTIC Science & Technology

    2015-10-01

    Pittsburgh, PA 15213 REPORT DATE: October 2015 TYPE OF REPORT: Annual Report PREPARED FOR: U.S. Army Medical Research and Materiel Command...Pittsburgh, Pa 15213-3320 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) U.S. Army Medical Research and...lamina elastic f. vasa vasorum involvement g. perivascular edema h. erythrocyte extravasation i. leukocyte adhesion j. leukocyte infiltration

  9. Advancements for continuous miners

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fiscor, S.

    2007-06-15

    Design changes and new technology make the modern continuous miner more user friendly. Two of the major manufacturers, Joy Mining Machinery and DBT, both based near Pittsburgh, PA, USA, have recently acquired other OEMs to offer a greater product line. Joy's biggest development in terms of improving cutting time is the FACEBOSS Control System which has an operator assistance element and Joy Surface Reporting Software (JSRP). Joy's WetHead continuous miners have excellent performance. DBT is researching ways to make the machines more reliable with new drive systems. It has also been experimenting with water sprays to improve dust suppression. 4more » photos.« less

  10. Using a Merit-Based Scholarship Program to Increase Rates of College Enrollment in an Urban School District: The Case of the Pittsburgh Promise

    ERIC Educational Resources Information Center

    Bozick, Robert; Gonzalez, Gabriella; Engberg, John

    2015-01-01

    The Pittsburgh Promise is a scholarship program that provides $5,000 per year toward college tuition for public high school graduates in Pittsburgh, Pennsylvania who earned a 2.5 GPA and a 90% attendance record. This study used a difference-in-difference design to assess whether the introduction of the Promise scholarship program directly…

  11. Pittsburgh Regional Healthcare Initiative puts new spin on improving healthcare quality.

    PubMed

    2002-11-01

    For nearly 4 years, the Pittsburgh Regional Healthcare Initiative (PRHI) has been working to improve the way healthcare is delivered in southwestern Pennsylvania by combining the voices and resources of hospitals, providers, the business community, insurers, health plans, and federal agencies. As one example of borrowing from business, the PRHI has created a new learning and management system, called Perfecting Patient Care, which is based on the Toyota Production System model and is now being used successfully in hospitals.

  12. Data Integration: Charting a Path Forward to 2035

    DTIC Science & Technology

    2011-02-14

    New York, NY: Gotham Books, 2004. Seligman , Len. Mitre Corporation, e-mail interview, 6 Dec 2010. Singer, P.W. Wired for War: The Robotics...articles.aspx (accessed 4 Dec 2010). Ultra-Large-Scale Systems: The Software Challenge of the Future. Study lead Linda Northrup. Pittsburgh, PA: Carnegie...Virtualization?‖ 1. 41 Ultra-Large-Scale Systems: The Software Challenge of the Future. Study lead Linda Northrup. Pittsburgh, PA: Carnegie Mellon Software

  13. Question Generation via Overgenerating Transformations and Ranking

    DTIC Science & Technology

    2009-01-01

    School of Computer Science Carnegie Mellon University 5000 Forbes Ave., Pittsburgh, PA 15213 www.lti.cs.cmu.edu c©2009, Michael Heilman and Noah A...PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Carnegie Mellon University ,School of Computer Science,5000 Forbes Ave,Pittsburgh,PA,15213 8...1967), in particular those that view a question as a transformation of a canonical declarative sentence ( Chomsky , 1973). In computational linguistics

  14. Functional Characterization of Phalaenopsis aphrodite Flowering Genes PaFT1 and PaFD

    PubMed Central

    Jang, Seonghoe; Choi, Sang-Chul; Li, Hsing-Yi; An, Gynheung; Schmelzer, Elmon

    2015-01-01

    We show that the key flowering regulators encoded by Phalaenopsis aphrodite FLOWERING LOCUS T1 (PaFT1) and PaFD share high sequence homologies to these from long-day flowering Arabidopsis and short-day flowering rice. Interestingly, PaFT1 is specifically up-regulated during flowering inductive cooling treatment but is not subjected to control by photoperiod in P. aphrodite. Phloem or shoot apex-specific expression of PaFT1 restores the late flowering of Arabidopsis ft mutants. Moreover, PaFT1 can suppress the delayed flowering caused by SHORT VEGATATIVE PHASE (SVP) overexpression as well as an active FRIGIDA (FRI) allele, indicating the functional conservation of flowering regulatory circuit in different plant species. PaFT1 promoter:GUS in Arabidopsis showed similar staining pattern to that of Arabidopsis FT in the leaves and guard cells but different in the shoot apex. A genomic clone or heat shock-inducible expression of PaFT1 is sufficient to the partial complementation of the ft mutants. Remarkably, ectopic PaFT1 expression also triggers precocious heading in rice. To further demonstrate the functional conservation of the flowering regulators, we show that PaFD, a bZIP transcription factor involved in flowering promotion, interacts with PaFT1, and PaFD partially complemented Arabidopsis fd mutants. Transgenic rice expressing PaFD also flowered early with increased expression of rice homologues of APETALA1 (AP1). Consistently, PaFT1 knock-down Phalaenopsis plants generated by virus-induced gene silencing exhibit delayed spiking. These studies suggest functional conservation of FT and FD genes, which may have evolved and integrated into distinct regulatory circuits in monopodial orchids, Arabidopsis and rice that promote flowering under their own inductive conditions. PMID:26317412

  15. Pittsburgh 2013 Energy Baseline: Consumption, Trends & Opportunities

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tarka, Thomas J.; James III, Robert E.; Withum, Jeffrey A.

    2017-03-01

    The United States (U.S.) Department of Energy (DOE) and the National Energy Technology Laboratory (NETL) are working in conjunction with the City of Pittsburgh (City) to transform how energy is produced, transported, and consumed in the City. This transformation will rely on 21st Century Energy Infrastructure designs, which leverage advanced technology and design techniques to modernize energy infrastructure, create new business models and markets, and expand technology research and development opportunities. Achieving this vision will require developing solutions that are unique to the City: its climate, topography, energy needs, resources, and existing infrastructure.a In this way, the City will demonstratemore » what the American “City of the Future” looks like, with all its attendant environmental, economic, and job-creation benefits. It will also serve as a template for other cities seeking to reinvent their energy systems.« less

  16. RIVERBANK AND MEADOW, LOOKING SOUTHEAST. PA148 AND PA149 CAN BE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    RIVERBANK AND MEADOW, LOOKING SOUTHEAST. PA-1-48 AND PA-1-49 CAN BE PAIRED TO FORM A PANORAMA SHOWING THE RELATIONSHIP BETWEEN THE RIVERBANK AND THE MEADOW - John Bartram House & Garden, 54th Street & Lindbergh Boulevard, Philadelphia, Philadelphia County, PA

  17. 12. Photocopy of lithograph (source unknown) The Armor Lithograph Company, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Photocopy of lithograph (source unknown) The Armor Lithograph Company, Ltd., Pittsburgh, Pennsylvania, ca. 1888 COURTHOUSE AND JAIL, FROM THE WEST - Allegheny County Courthouse & Jail, 436 Grant Street (Courthouse), 420 Ross Street (Jail), Pittsburgh, Allegheny County, PA

  18. Framework for Collaboration: Integrating School and Human Services Data in Pittsburgh. OCD Special Report

    ERIC Educational Resources Information Center

    University of Pittsburgh Office of Child Development, 2011

    2011-01-01

    This Special Report discusses how the Allegheny County Department of Human Services and Pittsburgh Public Schools took a major step toward closing a knowledge gap that prevents schools and human service agencies around the country from developing a deeper understanding of the children in their systems and collaborating on more effective, better…

  19. Gordon Research Conference in Organometallic Chemistry, held August 16-20, 1982 Andover, New Hampshire.

    DTIC Science & Technology

    1983-03-01

    Guido MLS 33 Mbtts, Graham MLS 31 Air Products and Chemicals , Inc . University of Pittsburgh PO Box 538 Chemistry Dept. Allentown, PA 18105 Pittsburgh... Products and Chemicals Inc . Boston College P0 Box 538, Corp Science Ctr. Chestnut Hill, MA 02167 AllenCwn, PA 18105 Nicholas, Paul Carriage 4 McGinnis...CA 94025 Dept of Chnmaistry Evanston, IL 60201 Organcietallic Chemistry Registration List -5- Marsella, John MLS 26 Nicholas, Kenneth MLS 31 Air

  20. Using the Feature Exchange Language in the Next Generation Controller

    DTIC Science & Technology

    1990-08-01

    IFCTE DEC 28 The Robotics InstituteCarnegie Mellon University Pittsburgh, PA 15213 LI 4 August 1990 Copyright 0 1990 Carnegie Mellon University The work...ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER The Robotics Institute Carnegie Mellon University CMU-RI-TR-90-19 Pittsburgh, PA...Basic Syntax 3.1.1. The Grammar The design of FEL syntax is based on a few simple concepts: (1) sentences, (2) verbs, (3) attributes with associated

  1. Public health assessment addendum for Letterkenny Army Depot, USA Letterkenny Southeast Area, Chambersburg, Franklin County, Pennsylvania, Region 3. CERCLIS No. PA6213820503 and USA Letterkenny, Property Disposal Office Area, Chambersburg, Franklin County, Pennsylvania. CERCLIS No. PA2210090054. Final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1993-05-25

    The Letterkenny Army Depot (Letterkenny) is five miles north of Chambersburg, in Franklin County, Pennsylvania. The US Army Depot consists of two National Priorities List (NPL) sites: USA Letterkenny Southeast Area (hereafter referred to as the SE Area) and USA Letterkenny - Property Disposal Office Area (hereafter referred to as the PDO Area). A public health assessment of those combined sites was released by the Agency for Toxic Substances and Disease Registry on September 30, 1988 (Appendix 1). The previous public health assessment combined discussion of both NPL sites due to similar contaminants and pathways. Since the release of themore » previous public health assessment, new environmental, community health concerns, and health outcome data have become available, warranting this addendum.« less

  2. The Nonprofit Clinic at the University of Pittsburgh: Preparing Students for Transition to Professional Settings

    ERIC Educational Resources Information Center

    Kearns, Kevin P.

    2014-01-01

    The Nonprofit Clinic at the University of Pittsburgh gives graduate students the opportunity to serve as management consultants to nonprofit organizations. This article describes the learning objectives, logistics, and outcomes of the Nonprofit Clinic. Bloom's 1956 taxonomy of learning objectives is employed to assess learning outcomes.

  3. 76 FR 57796 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-16

    ... CP Solomon at MP-PT 352.5 near Pittsburgh, PA, with an absolute block to be established in advance of... Solomon. 3. Operations on the Fort Wayne Line, Pittsburgh Division, from CP Rochester at MP-PC 29.5, near...

  4. Reduced-Order Modeling for Optimization and Control of Complex Flows

    DTIC Science & Technology

    2010-11-30

    Statistics Colloquium, Auburn, AL, (January 2009). 16. University of Pittsburgh, Mathematics Colloquium, Pittsburgh, PA, (February 2009). 17. Goethe ...Center for Scientific Computing, Goethe University Frankfurt am Main, Ger- many, (June 2009). 18. Air Force Institute of Technology, Wright-Patterson

  5. 31 CFR 351.86 - What is the role of Federal Reserve Banks and Branches?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., Maine, Massachusetts, New Hampshire, New Jersey (northern half), New York, Rhode Island, Vermont, Puerto Rico, Virgin Islands. Federal Reserve Bank, Pittsburgh Branch, 717 Grant Street, Pittsburgh, PA 15219... half), Maryland, Mississippi (southern half), North Carolina, South Carolina, Tennessee (eastern half...

  6. 31 CFR 359.71 - What is the role of Federal Reserve Banks and Branches?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., Maine, Massachusetts, New Hampshire, New Jersey (Northern half), New York, Rhode Island, Vermont, Puerto Rico, Virgin Islands. Federal Reserve Bank, Pittsburgh Branch, 717 Grant Street, Pittsburgh, PA 15219...), Maryland, Mississippi (southern half), North Carolina, South Carolina, Tennessee (eastern half), Virginia...

  7. Biennial Guidance Test Symposium (16th) Held in Holloman Air Force Base, New Mexico on October 5-7, 1993. Volume 1

    DTIC Science & Technology

    1993-10-01

    Michael Swamp, Contraves Inc., Pittsburgh PA; Dr. Michael D. Hooser, CIGTF, Holloman AFB NM Hig h Stability Large Centrifuge Test Bed 305 Dr. Louis A...DeMore, Robert Anticole, and Hans Riggenbach, Contraves Inc, Pittsburgh PA; Dr. Michael D. Hooser, CIGTF, Holloman AFB NM vi SESSION V-A: WEAPONS...power spectral density of input are also frozen out, allowing very low loss referred noise) of 10’ HzŖ below 100 Hz. springs. The input coils are

  8. Prosperity in Pittsburgh. Special Librarians Gather to Reaffirm the Ties that Bind this Varied and Growing Association

    ERIC Educational Resources Information Center

    Library Journal, 1973

    1973-01-01

    Everything, for the second year in a row, seemed to be looking up for the Special Libraries Association as it gathered in Pittsburgh in June. This article is a brief report on the conference. (Author/SJ)

  9. Detection of Isolated Cerebrovascular β-Amyloid with Pittsburgh Compound B

    PubMed Central

    Greenberg, SM; Grabowski; Gurol, ME; Skehan, ME; Nandigam, RNK; Becker, JA; Garcia-Alloza, M; Prada, C; Frosch, MP; Rosand, J; Viswanathan, A; Smith, EE; Johnson, KA

    2008-01-01

    Imaging of cerebrovascular β-amyloid (cerebral amyloid angiopathy, CAA) is complicated by this pathology’s nearly universal overlap with Alzheimer pathology. We performed PET imaging with Pittsburgh Compound B (PiB) on 42-year old man with early manifestations of Iowa-type hereditary CAA, a form of the disorder with little or no plaque deposits of fibrillar β-amyloid. The results demonstrated elevated PiB retention selectively in occipital cortex, sparing regions typically labeled in Alzheimer disease. These results offer compelling evidence that PiB-PET can noninvasively detect isolated CAA prior to overt signs of tissue damage such as hemorrhage or white matter lesions. PMID:19067370

  10. Endovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke

    PubMed Central

    Broderick, Joseph P.; Palesch, Yuko Y.; Demchuk, Andrew M.; Yeatts, Sharon D.; Khatri, Pooja; Hill, Michael D.; Jauch, Edward C.; Jovin, Tudor G.; Yan, Bernard; Silver, Frank L.; von Kummer, Rüdiger; Molina, Carlos A.; Demaerschalk, Bart M.; Budzik, Ronald; Clark, Wayne M.; Zaidat, Osama O.; Malisch, Tim W.; Goyal, Mayank; Schonewille, Wouter J.; Mazighi, Mikael; Engelter, Stefan T.; Anderson, Craig; Spilker, Judith; Carrozzella, Janice; Ryckborst, Karla J.; Janis, L. Scott; Martin, Renée H.; Foster, Lydia D.; Tomsick, Thomas A.

    2013-01-01

    BACKGROUND Endovascular therapy is increasingly used after the administration of intravenous tissue plasminogen activator (t-PA) for patients with moderate-to-severe acute ischemic stroke, but whether a combined approach is more effective than intravenous t-PA alone is uncertain. METHODS We randomly assigned eligible patients who had received intravenous t-PA within 3 hours after symptom onset to receive additional endovascular therapy or intravenous t-PA alone, in a 2:1 ratio. The primary outcome measure was a modified Rankin scale score of 2 or less (indicating functional independence) at 90 days (scores range from 0 to 6, with higher scores indicating greater disability). RESULTS The study was stopped early because of futility after 656 participants had undergone randomization (434 patients to endovascular therapy and 222 to intravenous t-PA alone). The proportion of participants with a modified Rankin score of 2 or less at 90 days did not differ significantly according to treatment (40.8% with endovascular therapy and 38.7% with intravenous t-PA; absolute adjusted difference, 1.5 percentage points; 95% confidence interval [CI], −6.1 to 9.1, with adjustment for the National Institutes of Health Stroke Scale [NIHSS] score [8–19, indicating moderately severe stroke, or ≥20, indicating severe stroke]), nor were there significant differences for the predefined subgroups of patients with an NIHSS score of 20 or higher (6.8 percentage points; 95% CI, −4.4 to 18.1) and those with a score of 19 or lower (−1.0 percentage point; 95% CI, −10.8 to 8.8). Findings in the endovascular-therapy and intravenous t-PA groups were similar for mortality at 90 days (19.1% and 21.6%, respectively; P = 0.52) and the proportion of patients with symptomatic intracerebral hemorrhage within 30 hours after initiation of t-PA (6.2% and 5.9%, respectively; P = 0.83). CONCLUSIONS The trial showed similar safety outcomes and no significant difference in functional independence with

  11. Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice

    PubMed Central

    Lund, Leif R; Green, Kirsty A; Stoop, Allart A; Ploug, Michael; Almholt, Kasper; Lilla, Jennifer; Nielsen, Boye S; Christensen, Ib J; Craik, Charles S; Werb, Zena; Danø, Keld; Rømer, John

    2006-01-01

    Simultaneous ablation of the two known activators of plasminogen (Plg), urokinase-type (uPA) and the tissue-type (tPA), results in a substantial delay in skin wound healing. However, wound closure and epidermal re-epithelialization are significantly less impaired in uPA;tPA double-deficient mice than in Plg-deficient mice. Skin wounds in uPA;tPA-deficient mice treated with the broad-spectrum matrix metalloproteinase (MMP) inhibitor galardin (N-[(2R)-2-(hydroxamido-carbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide) eventually heal, whereas skin wounds in galardin-treated Plg-deficient mice do not heal. Furthermore, plasmin is biochemically detectable in wound extracts from uPA;tPA double-deficient mice. In vivo administration of a plasma kallikrein (pKal)-selective form of the serine protease inhibitor ecotin exacerbates the healing impairment of uPA;tPA double-deficient wounds to a degree indistinguishable from that observed in Plg-deficient mice, and completely blocks the activity of pKal, but not uPA and tPA in wound extracts. These findings demonstrate that an additional plasminogen activator provides sufficient plasmin activity to sustain the healing process albeit at decreased speed in the absence of uPA, tPA and galardin-sensitive MMPs and suggest that pKal plays a role in plasmin generation. PMID:16763560

  12. Processing the CONSOL Energy, Inc. Mine Maps and Records Collection at the University of Pittsburgh

    ERIC Educational Resources Information Center

    Rougeux, Debora A.

    2011-01-01

    This article describes the efforts of archivists and student assistants at the University of Pittsburgh's Archives Service Center to organize, describe, store, and provide timely and efficient access to over 8,000 maps of underground coal mines in southwestern Pennsylvania, as well the records that accompanied them, donated by CONSOL Energy, Inc.…

  13. 78 FR 73584 - CSX Transportation, Inc.-Corporate Family Merger Exemption-Buffalo, Rochester and Pittsburgh Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-06

    ..., Inc.--Corporate Family Merger Exemption-- Buffalo, Rochester and Pittsburgh Company CSX Transportation... jointly filed a verified notice of exemption under 49 CFR 1180.2(d)(3) for a corporate family transaction... intends to merge BR&P into CSXT on or after that date. This is a transaction within a corporate family of...

  14. EnviroAtlas - Pittsburgh, PA - Estimated Intersection Density of Walkable Roads

    EPA Pesticide Factsheets

    This EnviroAtlas dataset estimates the intersection density of walkable roads within a 750 meter radius of any given 10 meter pixel in the community. Intersections are defined as any point where 3 or more roads meet and density is calculated using kernel density, where closer intersections are weighted higher than further intersections. Intersection density is highly correlated with walking for transportation. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

  15. 76 FR 27892 - Special Local Regulation; Allegheny River, Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ... established to safeguard participants of the Venture Outdoors Festival from the hazards of marine traffic... participants during the Venture Outdoors Festival marine event from the hazards imposed by marine traffic. The date of the Venture Outdoors Festival is tied to numerous other events and cannot be changed at this...

  16. EnviroAtlas - Pittsburgh, PA - 51m Riparian Buffer Vegetated Cover

    EPA Pesticide Factsheets

    This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is vegetated. There is a potential for decreased water quality in areas where the riparian buffer is less vegetated. The displayed line represents the center of the analyzed riparian buffer. The water bodies analyzed include hydrologically connected streams, rivers, connectors, reservoirs, lakes/ponds, ice masses, washes, locks, and rapids within the Atlas Area. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

  17. EnviroAtlas - Pittsburgh, PA - 51m Riparian Buffer Forest Cover

    EPA Pesticide Factsheets

    This EnviroAtlas dataset describes the percentage of a 51-m riparian buffer that is forested. There is a potential for decreased water quality in areas where the riparian buffer is less forested. The displayed line represents the center of the analyzed riparian buffer. The water bodies analyzed include hydrologically connected streams, rivers, connectors, reservoirs, lakes/ponds, ice masses, washes, locks, and rapids within the Atlas Area. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

  18. Fostering Student Interest in Neurologic Surgery: The University of Pittsburgh Experience.

    PubMed

    Kashkoush, Ahmed; Feroze, Rafey; Myal, Stephanie; Prabhu, Arpan V; Sansosti, Alexandra; Tonetti, Daniel; Agarwal, Nitin

    2017-12-01

    Early involvement and research in neurosurgery can increase chances for medical students to matriculate successfully into residency. This study reports the creation of a Neurological Surgery Interest Group (NSIG) at the University of Pittsburgh School of Medicine and shares its activities over 2 academic years. In October 2014, the University of Pittsburgh School of Medicine's NSIG was created to augment medical student interest in neurosurgery. The group consisted of 4 appointed officers for a membership base of 100 students. In June 2015, a neurosurgery resident and faculty member joined as mentors. A research committee of 14 medical students was created to conduct collaborative research projects with the department. In August of 2015 and 2016, surveys were sent out to the research committee regarding research productivity. The NSIG hosted 17 medical student-oriented events over 2 years, including didactic and suturing workshops, senior faculty panels, postmatch talks, and a neurosurgery networking dinner. A survey of students about scholarly achievement in neurosurgery reported 17 accepted publications in peer-reviewed journals with a mean impact factor of 3.5 ± 2.5. Ten abstracts were submitted to the 2015 and 2016 American Association of Neurological Surgeons Scientific Meetings, with a 100% acceptance rate. An increase in the number of students matching from our institution into neurosurgery residencies was observed following the group's inception. An NSIG can be mutually beneficial to both medical students and an institution's neurosurgical department. This study's findings may be applied to numerous specialties and across various academic institutions. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. Lighting retrofits at the Pittsburgh Zoo and Aviary

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sadowski, E.C.

    The Pittsburgh Zoo occupies approximately 52 acres in the City`s Highland Park. Thirty structures serve as animal holding facilities, public display buildings, classrooms, food service facilities, offices, warehouses, a veterinary hospital, and gift shops. The cost of energy for heating, cooling, lighting, pumping, food service, etc. is approximately $280,000 a year. Of this, about 79 percent, or $220,000, is spent for electricity. About 20 percent ($44,000) of that electricity cost is spent directly on lighting. In mid-1992 a series of retrofits to the lighting systems in the Zoo`s buildings was begun. These were completed in mid-1994. These improvements cost $127,690,more » and they are expected to reduce electricity costs by $24,500 a year. The most interesting projects were carried out in the Tropical Forest Building, the Aqua Zoo, and the Niches of the World Building.« less

  20. Transcripts of Regional Hearings, Seattle, Washington: Annex L to Adjusting to the Drawdown Report of the Defense Conversion Commission

    DTIC Science & Technology

    1992-09-24

    California, and MagLev , Inc., in 2 Pittsburgh, Pennsylvania. 3 Also, panel recommendations from the New York Defense Spending and 4 Impact Report...enhancement and job development. Examples of these consortiums include Calstart in Los Angeles, Ca. and Maglev , Inc. in Pittsburgh, Pa. - Panel

  1. Structure and activity of the Pseudomonas aeruginosa hotdog-fold thioesterases PA5202 and PA2801.

    PubMed

    Gonzalez, Claudio F; Tchigvintsev, Anatoli; Brown, Greg; Flick, Robert; Evdokimova, Elena; Xu, Xiaohui; Osipiuk, Jerzy; Cuff, Marianne E; Lynch, Susan; Joachimiak, Andrzej; Savchenko, Alexei; Yakunin, Alexander F

    2012-06-15

    The hotdog fold is one of the basic protein folds widely present in bacteria, archaea and eukaryotes. Many of these proteins exhibit thioesterase activity against fatty acyl-CoAs and play important roles in lipid metabolism, cellular signalling and degradation of xenobiotics. The genome of the opportunistic pathogen Pseudomonas aeruginosa contains over 20 genes encoding predicted hotdog-fold proteins, none of which have been experimentally characterized. We have found that two P. aeruginosa hotdog proteins display high thioesterase activity against 3-hydroxy-3-methylglutaryl-CoA and glutaryl-CoA (PA5202), and octanoyl-CoA (PA2801). Crystal structures of these proteins were solved (at 1.70 and 1.75 Å for PA5202 and PA2801 respectively) and revealed a hotdog fold with a potential catalytic carboxylate residue located on the long α-helix (Asp(57) in PA5202 and Glu(35) in PA2801). Alanine residue replacement mutagenesis of PA5202 identified four residues (Asn(42), Arg(43), Asp(57) and Thr(76)) that are critical for its activity and are located in the active site. A P. aeruginosa PA5202 deletion strain showed an increased secretion of the antimicrobial pigment pyocyanine and an increased expression of genes involved in pyocyanin biosynthesis, suggesting a functional link between PA5202 activity and pyocyanin production. Thus the P. aeruginosa hotdog thioesterases PA5202 and PA2801 have similar structures, but exhibit different substrate preferences and functions.

  2. The Effects of the Air Cast Sports Stirrup on Postural Sway in Normal Males

    DTIC Science & Technology

    1993-01-01

    Pittsburgh Pittsburgh, PAI Paula Sammarone, MA, ATC Date Rangos School of Health Sciences I Director, Athletic Training Duquesne University I Pittsburgh, PA I...sprain occurs, tearing of the ligaments also occur, which results in de- afferentization of the articular nerves (20). 1 Several treatment modalities...intermediate ranges. Articular nerve fibers have lower tensile strength than collagen fibers (21). Since most inversion injuries of the ankle result in some

  3. 76 FR 41556 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-14

    ... Cannon at MP-PT 118.9 near Duncannon, PA to CP Solomon at MP-PT 352.5 near Pittsburgh, PA, with the... between CP Bloom at MP-PT 351.6 near Pittsburg, PA and CP Solomon. Operations on the Fort Wayne Line...

  4. Case volumes of intra-arterial and intravenous treatment of ischemic stroke in the USA.

    PubMed

    Hirsch, J A; Yoo, A J; Nogueira, R G; Verduzco, L A; Schwamm, L H; Pryor, J C; Rabinov, J D; González, R G

    2009-07-01

    Ischemic stroke is a major cause of disability and death in the USA. Intravenous tissue plasminogen activator (t-PA) remains underutilized. With the development of newer intra-arterial reperfusion therapies, there is increased opportunity to address the more devastating large-vessel occlusions. We seek to identify the numbers of patients with stroke treated with intravenous and intra-arterial therapies, as well as to estimate the potential number of intra-arterial cases in the foreseeable future. We performed a literature search to determine case volumes of intravenous t-PA use. We extrapolated the current case volume of intra-arterial stroke therapies from the numbers of cases in which the Merci retrieval device was used. In order to estimate the potential numbers of intra-arterial stroke cases, we characterized the percentage of patients with stroke who received intra-arterial therapy at two leading stroke centers. We applied these percentages to the numbers of patients with stroke seen at the top 100, 200 and 500 stroke centers by volume. The rate of intravenous t-PA use is 2.4-3.6%, resulting in 15 000-22 000 cases/year in the USA. The estimated case volume of intra-arterial therapies is 3500-7200 in 2006. Based on data from St. Luke's Brain and Stroke Institute and Massachusetts General Hospital, approximately 5-20% of patients with ischemic stroke can be treated with intra-arterial therapies. Extrapolating this to the top 500 stroke centers by volume, the potential number of intra-arterial cases in the USA is 10 400-41 500/year. Based on the current numbers of intra-arterial cases, our theoretical model identifies a potential for significant growth of this stroke therapy.

  5. Targeting Histone Abnormality in Triple-Negative Breast Cancer

    DTIC Science & Technology

    2015-08-01

    Oncology Pediatric Hematology/Oncology BMT & CT Conference, Childrens Hospital of Pittsburgh, Pittsburgh, PA University of Pittsburgh, Winter...Release; Distribution Unlimited The views, opinions and/or findings contained in this report are those of the author( s ) and should not be construed as...ELEMENT NUMBER N/A 6. AUTHOR( S ) 5d. PROJECT NUMBER N/A Nancy E. Davidson, M.D. 5e. TASK NUMBER N/A E-Mail:davidsonne@upmc.edu 5f. WORK

  6. Structure and activity of the Pseudomonas aeruginosa hotdog-fold thioesterases PA5202 and PA2801

    PubMed Central

    Gonzalez, Claudio F.; Tchigvintsev, Anatoli; Brown, Greg; Flick, Robert; Evdokimova, Elena; Xu, Xiaohui; Osipiuk, Jerzy; Cuff, Marianne E.; Lynch, Susan; Joachimiak, Andrzej; Savchenko, Alexei; Yakunin, Alexander F.

    2013-01-01

    The hotdog fold is one of the basic protein folds widely present in bacteria, archaea, and eukaryotes. Many of these proteins exhibit thioesterase activity against fatty acyl-CoAs and play important roles in lipid metabolism, cellular signaling, and degradation of xenobiotics. The genome of the opportunistic pathogen Pseudomonas aeruginosa contains over 20 genes encoding predicted hotdog-fold proteins, none of which have been experimentally characterized. We have found that two P. aeruginosa hotdog proteins display high thioesterase activity against 3-hydroxy-3-methylglutaryl-CoA and glutaryl-CoA (PA5202), and octanoyl-CoA (PA2801). Crystal structures of these proteins were solved (1.70 and 1.75 Å) and revealed a hotdog fold with a potential catalytic carboxylate residue located on the long alpha helix (Asp57 in PA5202 and Glu35 in PA2801). Alanine replacement mutagenesis of PA5202 identified four residues (Asn42, Arg43, Asp57, and Thr76), which are critical for activity and are located in the active site. A P. aeruginosa PA5202 deletion strain showed an increased secretion of the antimicrobial pigment pyocyanine and an increased expression of genes involved in pyocyanin biosynthesis suggesting a functional link between the PA5202 activity and pyocyanin production. Thus, the P. aeruginosa hotdog thioesterases PA5202 and PA2801 have similar structures, but exhibit different substrate preferences and functions. PMID:22439787

  7. Pharmacodynamic evaluation of clopidogrel plus PA32540: the Spaced PA32540 With Clopidogrel Interaction Gauging (SPACING) study.

    PubMed

    Gurbel, P A; Bliden, K P; Fort, J; Zhang, Y; Plachetka, J R; Antonino, M; Gesheff, M; Tantry, U S

    2011-12-01

    PA32540 combines 325 mg enteric-coated (EC) aspirin (ASA) with 40 mg immediate-release omeprazole; its influence on the antiplatelet effect of clopidogrel (C) is unknown. In this randomized, open-label study, subjects (n = 30) were treated with (i) 300 mg C + 325 mg ECASA followed by 75 mg C + 325 mg ECASA on days 2-7, (ii) 300 mg C + PA32540 followed by 75 mg C + PA32540 on days 2-7, or (iii) PA32540 in the morning + 300 mg C 10 h later on day 1 and PA32540 in the morning + 75 mg C 10 h later on days 2-7. We analyzed the noninferiority of PA32540 relative to ECASA, as defined by the upper bound of the 95% confidence interval ≤10% for the difference in least-square means of platelet inhibition between the treatments. As compared to ECASA+C, synchronous treatment of PA32540+C was not noninferior, whereas the spacing strategy of PA32540+C was noninferior. Spacing the administration of PA32540 and clopidogrel lessens the interaction observed with synchronous administration; PA32540 administration with clopidogrel may be associated with a different antiplatelet profile.

  8. Creating Social Connections in Higher Education: Insights from the Campus Canines Program at the University of Pittsburgh

    ERIC Educational Resources Information Center

    Camaioni, Nicole

    2013-01-01

    The overall purpose of this study was to capture the relationships made during the Campus Canines Program, an animal-assisted activity program, at the University of Pittsburgh. Meaningful social relationships create greater educational satisfaction. These social relationships are an important piece to creating and sustaining student involvement,…

  9. Improved wastewater treatment at Wheeling-Pittsburgh Steel Corporations`s Steubenville East Coke Plant

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Goshe, A.J.; Nodianos, M.J.

    1995-12-01

    Wheeling-Pittsburgh Steel Corporation recently improved its wastewater treatment at it`s by-products coke plant. This has led to greatly improved effluent quality. Excess ammonia liquor, along with wastewater from the light oil recovery plant, desulfurization facility, and coal pile runoff, must be treated prior to being discharged into the Ohio River. This is accomplished using a biological wastewater treatment plant to remove 99.99% of the organic contaminants and ammonia. Biologically treated, clarified wastewater is now polished in the newly constructed tertiary treatment plant.

  10. PersonA: Persuasive social network for physical Activity.

    PubMed

    Ayubi, Soleh U; Parmanto, Bambang

    2012-01-01

    Advances in physical activity (PA) monitoring devices provide ample opportunities for innovations in the way the information produced by these devices is used to encourage people to have more active lifestyles. One such innovation is expanding the current use of the information from self-management to social support. We developed a Persuasive social network for physical Activity (PersonA) that combines automatic input of physical activity data, a smartphone, and a social networking system (SNS). This paper describes the motivation for and overarching design of the PersonA and its functional and non-functional features. PersonA is designed to intelligently and automatically receive raw PA data from the sensors in the smartphone, calculate the data into meaningful PA information, store the information on a secure server, and show the information to the users as persuasive and real-time feedbacks or publish the information to the SNS to generate social support. The implementation of self-monitoring, social support, and persuasive concepts using currently available technologies has the potential for promoting healthy lifestyle, greater community participation, and higher quality of life. We also expect that PersonA will enable health professionals to collect in situ data related to physical activity. The platform is currently being used and tested to improve PA level of three groups of users in Pittsburgh, PA, USA.

  11. Measuring stigma in children receiving mental health treatment: Validation of the Paediatric Self-Stigmatization Scale (PaedS).

    PubMed

    Kaushik, A; Papachristou, E; Dima, D; Fewings, S; Kostaki, E; Ploubidis, G B; Kyriakopoulos, M

    2017-06-01

    Research on the impact of stigma associated with mental illness in children is scarce. Considering the known negative effects of stigma associated with mental illness in adults, it is crucial to explore the stigma experienced by children who access mental health treatment. However, no scale measuring self-stigmatization in younger children is available to date. This study aimed to develop and validate such a scale, the Paediatric Self-Stigmatization Scale (PaedS). A total of 156 children (119 receiving outpatient and 37 receiving inpatient treatment), aged 8-12 years, completed the PaedS, the Self-Perception Profile for Children and the Pediatric Quality of Life Inventory (PedsQL - Child Report, ages 8-12). In addition, parents completed the PedsQL (Parent Report for Children, ages 8-12), the Strengths and Difficulties Questionnaire (SDQ) and a modified subscale of the PaedS measuring the children's rejection by others due to their mental health difficulties. A confirmatory factor analysis showed that a four-factor structure, comprising Societal Devaluation, Personal Rejection, Self-Stigma and Secrecy scales, had excellent fit to the data (CFI=0.95; TLI=0.95; RMSEA=0.05). Child-reported PaedS scores were positively correlated with parental-reported PaedS scores and negatively with PedsQL, the SDQ, and 5 out of 6 subscales of the Self-Perception Profile for Children, suggesting adequate convergent validity (all P-values<0.05). The PaedS is a valid instrument, which is hoped to advance the understanding of self-stigmatization in children with mental health difficulties and contribute to its prevention. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  12. The Headwaters District: A History of the Pittsburgh District, U.S. Army Corps of Engineers

    DTIC Science & Technology

    1978-01-01

    bridges an average of 52 days each year and small towboats were obstructed 17.7 days a year. Sibert recommended in 1904 that the government require...not "unreasonable" obstructions , but his successor William Howard Taft disagreed and appointed an investigating board which in 1911 recommended the...Senator William B. Rodgers, Jr ., uniting political and civic leaders of the Pittsburgh vicinity in a campaign for federal flood control. They pressed

  13. An Experimental System for Research on Dynamic Skills Training.

    DTIC Science & Technology

    1981-09-01

    Bogey to be intercepted. The student enters B1 . The system then displays a recommended intercept heading, say 270 degrees. The student must now send this...DRIVE LRDC OTTAWA, CANADA K1A 0K2 UNIVERSITY OF PITTSBURGH 3939 O’HARA STREET ERIC Facility-Acquisitions PITTSBURGH, PA 15213 4833 Rugby Avenue Bethesda

  14. New Whole-House Solutions Case Study: Evaluating Through-Wall Air Transfer Fans, Pittsburgh, Pennsylvania

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    2014-10-01

    In this project, Building America team IBACOS performed field testing in a new construction unoccupied test house in Pittsburgh, Pennsylvania, to evaluate heating, ventilating, and air conditioning (HVAC) distribution systems during heating, cooling, and midseason conditions. The team evaluated a market-available through-wall air transfer fan system that provides air to the bedrooms.The relative ability of this system was considered with respect to relevant Air Conditioning Contractors of America and ASHRAE standards for house temperature uniformity and stability.

  15. Enzyme-linked immunosorbent assay using a recombinant baculovirus-expressed Bacillus anthracis protective antigen (PA): measurement of human anti-PA antibodies.

    PubMed Central

    Iacono-Connors, L C; Novak, J; Rossi, C; Mangiafico, J; Ksiazek, T

    1994-01-01

    We developed an antigen capture enzyme-linked immunosorbent assay (ELISA) which does not require purified protective antigen (PA) for detection of human antibodies to Bacillus anthracis PA. Lysates of Spodoptera frugiperda (Sf-9) cells infected with recombinant baculovirus containing the PA gene were used as the source of PA to develop the ELISA. Recombinant PA from crude Sf-9 cell lysates or PA purified from B. anthracis Sterne strain was captured by an anti-PA monoclonal antibody coated onto microtiter plates. We demonstrated that human serum antibody titers to PA were identical in the ELISA whether we used crude Sf-9 cell lysates containing recombinant baculovirus-expressed PA or purified Sterne PA. Finally, false-positive results observed in a direct ELISA were eliminated with this antigen capture ELISA. Thus, the antigen capture ELISA with crude preparations of baculovirus-expressed PA is reliable, safe, and inexpensive for determining anti-PA antibody levels in human sera. PMID:7496927

  16. A chronicle of PA journals.

    PubMed

    Hooker, Roderick S

    2017-02-01

    At its semicentennial mark, the PA profession appears to be flourishing. Over the past 50 years, a number of journals have emerged to highlight the development of the profession and offer observations on it. The Physician Associate Journal, launched in 1970, was the first foray into PA reporting. Following this small effort, a dozen journals or newspapers came into print, lasted for a while, and then were replaced or died. Of journals that survived to the present, four are in English and one in Dutch. Three of the five journals are association-based, and four produce clinical articles; publication is monthly, quarterly, or semiannually. Two journals produce original health services research or studies on the PA education process and have citable track records. Readership of all journals is growing, and collectively these periodicals produce a body of scholarly work that clarifies the PA as a healthcare professional growing on a world stage. This article describes the journalistic history of one aspect of PA development.

  17. Bridge: Intelligent Tutoring with Intermediate Representations

    DTIC Science & Technology

    1988-05-01

    Research and Development Center and Psychology Department University of Pittsburgh Pittsburgh, PA. 15260 The Artificial Intelligence and Psychology...problem never introduces more than one unfamiliar plan. Inteligent Tutoring With Intermediate Representations - Bonar and Cunniigbam 4 You must have a... Inteligent Tutoring With ntermediate Representations - Bonar and Cunningham 7 The requirements are specified at four differcnt levels, corresponding to

  18. EnviroAtlas - Pittsburgh, PA - Estimated Percent Tree Cover Along Walkable Roads

    EPA Pesticide Factsheets

    This EnviroAtlas dataset estimates tree cover along walkable roads. The road width is estimated for each road and percent tree cover is calculated in a 8.5 meter strip beginning at the estimated road edge. Percent tree cover is calculated for each block between road intersections. Tree cover provides valuable benefits to neighborhood residents and walkers by providing shade, improved aesthetics, and outdoor gathering spaces. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

  19. Oral Health in a Sample of Pregnant Women from Northern Appalachia (2011–2015)

    PubMed Central

    Neiswanger, Katherine; McNeil, Daniel W.; Foxman, Betsy; Govil, Manika; Cooper, Margaret E.; Weyant, Robert J.; Shaffer, John R.; Crout, Richard J.; Simhan, Hyagriv N.; Beach, Scott R.; Chapman, Stella; Zovko, Jayme G.; Brown, Linda J.; Strotmeyer, Stephen J.; Maurer, Jennifer L.; Marazita, Mary L.

    2015-01-01

    Background. Chronic poor oral health has a high prevalence in Appalachia, a large region in the eastern USA. The Center for Oral Health Research in Appalachia (COHRA) has been enrolling pregnant women and their babies since 2011 in the COHRA2 study of genetic, microbial, and environmental factors involved in oral health in Northern Appalachia. Methods. The COHRA2 protocol is presented in detail, including inclusion criteria (healthy, adult, pregnant, US Caucasian, English speaking, and nonimmunocompromised women), recruiting (two sites: Pittsburgh, Pennsylvania, and West Virginia, USA), assessments (demographic, medical, dental, psychosocial/behavioral, and oral microbial samples and DNA), timelines (longitudinal from pregnancy to young childhood), quality control, and retention rates. Results. Preliminary oral health and demographic data are presented in 727 pregnant women, half from the greater Pittsburgh region and half from West Virginia. Despite similar tooth brushing and flossing habits, COHRA2 women in West Virginia have significantly worse oral health than the Pittsburgh sample. Women from Pittsburgh are older and more educated and have less unemployment than the West Virginia sample. Conclusions. We observed different prevalence of oral health and demographic variables between pregnant women from West Virginia (primarily rural) and Pittsburgh (primarily urban). These observations suggest site-specific differences within Northern Appalachia that warrant future studies. PMID:26089906

  20. Male mental health problems, psychopathy, and personality traits: key findings from the first 14 years of the Pittsburgh Youth Study.

    PubMed

    Loeber, R; Farrington, D P; Stouthamer-Loeber, M; Moffitt, T E; Caspi, A; Lynam, D

    2001-12-01

    This paper reviews key findings on juvenile mental health problems in boys, psychopathy, and personality traits, obtained in the first 14 years of studies using data from the Pittsburgh Youth Study. This is a study of 3 samples, each of about 500 boys initially randomly drawn from boys in the 1st, 4th, and 7th grades of public schools in Pittsburgh. The boys have been followed regularly, initially each half year, and later at yearly intervals. Currently, the oldest boys are about 25 years old, whereas the youngest boys are about 19. Findings are presented on the prevalence and interrelation of disruptive behaviors, ADHD, and depressed mood. Results concerning risk factors for these outcomes are reviewed. Psychological factors such as psychopathy, impulsivity, and personality are described. The paper closes with findings on service delivery of boys with mental health problems.

  1. Identification of novel amino acid residues of influenza virus PA-X that are important for PA-X shutoff activity by using yeast.

    PubMed

    Oishi, Kohei; Yamayoshi, Seiya; Kawaoka, Yoshihiro

    2018-03-01

    The influenza A virus protein PA-X comprises an N-terminal PA region and a C-terminal PA-X-specific region. PA-X suppresses host gene expression, termed shutoff, via mRNA cleavage. Although the endonuclease active site in the N-terminal PA region of PA-X and basic amino acids in the C-terminal PA-X-specific region are known to be important for PA-X shutoff activity, other amino acids may also play a role. Here, we used yeast to identify novel amino acids of PA-X that are important for PA-X shutoff activity. Unlike wild-type PA-X, most PA-X mutants predominantly localized in the cytoplasm, indicating that these mutations decreased the shutoff activity of PA-X by affecting PA-X translocation to the nucleus. Mapping of the identified amino acids onto the N-terminal structure of PA revealed that some of them likely contribute to the formation of the endonuclease active site of PA. Copyright © 2018. Published by Elsevier Inc.

  2. A Study of Problems and Stress of Southeast Asian Students with Accompanying Families at the University of Pittsburgh.

    ERIC Educational Resources Information Center

    Ruetrakul, Pimon

    The perceptions of Southeast Asian graduate students at the University of Pittsburgh were explored. The students were asked to elucidate the problems which arose as they and their families adapted to the American experience. Findings are reported in seven categories. They are the following: (1) academic expenses did not cause financial problems…

  3. Dual Mode Thin Film Bulk Acoustic Resonators (FBARs) Based on AlN, ZnO and GaN Films with Tilted c-Axis Orientation

    DTIC Science & Technology

    2010-01-01

    TERMS MEMS , acoustic wave devices, acoustic wave sensors Qing-Ming Wang University of Pittsburgh 123 University Place University Club Pittsburgh, PA...resonators,” Proc. SPIE Vol. 6223, 62230I, Micro ( MEMS ) and Nanotechnologies for Space Applications; Thomas George, Zhong-Yang Cheng; Eds. (May...microelectromechanical resonators has been recognized as a technological challenge in the current microelectronics and MEMS development. The

  4. Defining the challenges of the Modern Analytical Laboratory (CPSA USA 2014): the risks and reality of personalized healthcare.

    PubMed

    Weng, Naidong; Needham, Shane; Lee, Mike

    2015-01-01

    The 17th Annual Symposium on Clinical and Pharmaceutical Solutions through Analysis (CPSA) 29 September-2 October 2014, was held at the Sheraton Bucks County Hotel, Langhorne, PA, USA. The CPSA USA 2014 brought the various analytical fields defining the challenges of the modern analytical laboratory. Ongoing discussions focused on the future application of bioanalysis and other disciplines to support investigational new drugs (INDs) and new drug application (NDA) submissions, clinical diagnostics and pathology laboratory personnel that support patient sample analysis, and the clinical researchers that provide insights into new biomarkers within the context of the modern laboratory and personalized medicine.

  5. 1984-1985 ANSMET Season

    NASA Astrophysics Data System (ADS)

    Sandford, Scott

    The Antarctic Search for Meteorites program (ANSMET), under the overall direction of W. A. Cassidy (University of Pittsburgh, Pittsburgh, Pa.), continued its work of past years by conducting an expedition to southern Victoria Land during the 1984-1985 austral summer. Party members included Cassidy, Catherine King-Frazier (James Madison University, Harrisonburg, Va.), Scott Sandford (Washington University, St. Louis, Mo.), John Schutt (University of Pittsburgh), Roberta Score (National Aeronautics and Space Administration/Johnson Space Center, Houston, Tex.), Carl Thompson (a freelance mountaineer from Canterbury, New Zealand), and Robert Walker (Washington University).

  6. Aging and space flight: findings from the University of Pittsburgh

    NASA Technical Reports Server (NTRS)

    Monk, T. H.

    1999-01-01

    For more than a decade, the Sleep and Chronobiology Center (SCC) at the University of Pittsburgh has received funding from the National Institute on Aging (NIA), the National Institute of Mental Health (NIMH) and the National Aeronautics and Space Administration (NASA) in order to study the sleep and circadian rhythms of healthy older people, as well as the sleep and circadian rhythms of astronauts and cosmonauts. We have always been struck by the strong synergism between the two endeavors. What happens to the sleep and circadian rhythms of people removed from the terrestrial time cues of Earth is in many ways similar to what happens to people who are advancing in years. Most obviously, sleep is shorter and sleep depth is reduced, but there are also more subtle similarities between the two situations, both in circadian rhythms and in sleep, and in the adaptive strategies needed to enhance 24h zeitgebers.

  7. Sino-U.S. partnerships in research, education, and patient care: The experience of the University of Pittsburgh and UPMC.

    PubMed

    Levine, Arthur S; McDonald, Margaret C; Bogosta, Charles E

    2017-10-01

    In 2011, the University of Pittsburgh School of Medicine (UPSOM) and Tsinghua University formed a partnership to further the education of Tsinghua medical students. These students come to UPSOM as visiting research scholars for two years of their eight-year MD curriculum. During this time, the students, who have completed four years at Tsinghua, work full-time in medical school laboratories and research programs of their choice, essentially functioning as graduate students. In their first two months in Pittsburgh, the scholars have a one-week orientation to biomedical research, followed by two-week rotations in four labs selected on the basis of the scholars' scientific interests, after which they choose one of these labs for the remainder of the two years. Selected labs may be in basic science departments, basic science divisions of clinical departments, or specialized centers that focus on approaches like simulation and modeling. The Tsinghua students also have a brief exposure to clinical medicine. UPSOM has also formed a similar partnership with Central South University Xiangya School of Medicine in Changsha, Hunan Province. The Xiangya students come to UPSOM for two years of research training after their sixth year and, thus, unlike the Tsinghua students, have already completed their clinical rotations. UPSOM faculty members have also paved the way for UPMC (University of Pittsburgh Medical Center), UPSOM's clinical partner, to engage with clinical centers in China. Major relationships involving advisory, training, managerial, and/or equity roles exist with Xiangya International Medical Center, KingMED Diagnostics, First Chengmei Medical Industry Group, and Macare Women's Hospital. Both UPSOM and UPMC are actively exploring other clinical and academic opportunities in China.

  8. Validation of the French version of the Pittsburgh Sleep Quality Index Addendum for posttraumatic stress disorder

    PubMed Central

    Ait-Aoudia, Malik; Levy, Pierre P.; Bui, Eric; Insana, Salvatore; de Fouchier, Capucine; Germain, Anne; Jehel, Louis

    2013-01-01

    Background Sleep disturbances are one of the main complaints of patients with trauma-related disorders. The original Pittsburgh Sleep Quality Index Addendum for PTSD (PSQI-A) is self-report instrument developed to evaluate posttraumatic stress disorder (PTSD)-specific sleep disturbances in trauma-exposed individuals. However, to date, the PSQI-A has not yet been translated nor validated in French. Objective The present study aims to: a) translate the PSQI-A into French, and b) examine its psychometric properties. Method Seventy-three adult patients (mean age=40.3 [SD=15.0], 75% females) evaluated in a specialized psychotraumatology unit completed the French versions of the PSQI-A, Pittsburgh Sleep Quality Index (PSQI), Hospital Anxiety and Depression Scale (HADS), and Impact Event Scale-Revised (IES-R). Results The French version of the PSQI-A showed satisfactory internal consistency, inter-item correlations, item correlations with the total score, convergent validity with PTSD and anxiety measures, and divergent validity with a depression measure. Conclusion Our findings support the use of the French version of the PSQI-A for both clinical care and research. The French version of the PSQI-A is an important addition to the currently available instruments that can be used to examine trauma-related sleep disturbances among French-speaking individuals. PMID:24044071

  9. Sliding friction study of the oscillating translational motion for steel on PA66 and PA46 type materials

    NASA Astrophysics Data System (ADS)

    Lates, M. T.; Velicu, R. G.; Papuc, R.

    2016-08-01

    The paper presents the study of the friction, by using tests, in the sliding translational oscillating motion of the steel on PA46 relative to the steel on PA66 type materials by considering as variables the testing parameters as: the load, the velocity and the operating temperature. The paper starts with a study of the literature and, according to that, presents the main conclusions regarding the sliding friction of the steel on PA66 and PA46 type materials and identifies the lacks of the results. The tests are performed on an oscillating motion type tribometer module. First, it is made a running-in program, for each of the materials, at 25 and 90°C, a load of 5 N and a frequency of 1 Hz for one hour; after that, there are performed tests at 90°C and 120°C, at loads of 3 N, 5 N, 7 N and at frequencies at 0.25 Hz, 5 Hz and 1 Hz. The results are presented for the PA46 type material relative to the PA66 material. The conclusions indicate in which conditions and with which advantages are used the PA66 and PA46 polyamides in the case of oscillating translational motions.

  10. Inadequate Sleep and Exercise Associated with Burnout and Depression Among Medical Students.

    PubMed

    Wolf, Megan R; Rosenstock, Jason B

    2017-04-01

    The authors studied whether low levels of exercise or inadequate sleep correlated with higher levels of burnout and depression in medical students. Medical students of all years at the University of Pittsburgh School of Medicine, Pittsburgh, PA, USA, were invited to participate in an anonymous online survey in Fall 2012 and Winter 2013. Validated measures were used to assess exercise, sleep, burnout, and depression. Response rates were 28.7 % at the beginning of the school year and 22.6 % at the middle of the school year. Burnout rates overall were 22.4 % at the beginning of the year and 19.2 % in the middle of the year. Eight percent of students screened positive for depression at the beginning of the year and 9.3 % in the middle of the year. Decreased exercise frequency was significantly correlated with lower professional efficacy. Pathological sleepiness was significantly associated with a higher prevalence of burnout. Inadequate sleep correlated with significantly lower professional efficacy and higher exhaustion scores. Burnout was associated with a positive depression screen. Positive depression screening, pathological sleepiness, and sleeping less than 7 h a night were independent predictors of burnout. Sleep habits, exercise, and a positive depression screen were associated with burnout risk within the medical student population.

  11. 75 FR 69468 - Metlife Moosic, PA, Metlife Clarks Summit, PA; Notice of Affirmative Determination Regarding...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-12

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-73,210; TA-W-73,210A] Metlife Moosic, PA, Metlife Clarks Summit, PA; Notice of Affirmative Determination Regarding Application for Reconsideration By application dated August 2, 2010, the petitioners requested administrative reconsideration of...

  12. Bug Distribution and Pattern Classification.

    DTIC Science & Technology

    1985-07-15

    Center Educational Psychology University of Leyden San Diego. CA 92152 Urbana. IL 61801 Education Research Center oernaavelaan 2 Dr. Erling B. Andersen...Dr. Dattprasad rlivgi 23314 EN Leyden Department of Statistics Syracuse University The NETHERLANDS 3tudiestraede 6 Department of Psychology 1455...Rebecca Hetter Learning R&D Center Navy Personnel R&D Center University of Pittsburgh Ms. Kathleen Moreno Code 62 Pittsburgh, PA 15260 Navy Personnel R

  13. Behavior and Attitudes under Crisis Conditions: Selected Issues and Findings.

    DTIC Science & Technology

    1984-02-01

    1617 Cathedral of Learning, Univ. of Pittsburgh 4851A Pittsburgh, PA 15260 It. CONTROLLING OFFICE NAME AND ADDRESS 12. REPORT DATE February 1984Federal...rests. The research design primarily consists of the examination of available research on conjunction with crises. This examination seeks three lofty...necessarily compares such attitudes and behaviors to those associated with non -crisis conditions. This objective seeks an answer to the fundamental

  14. Using Theory and Simulation to Design Self-Healing Surfaces

    DTIC Science & Technology

    2007-11-16

    blends, microcapsules Anna C. Balazs University of Pittsburgh Office of Sponsored Programs 3700 O’Hara St Pittsburgh, PA 15260 - REPORT DOCUMENTATION PAGE...novel computational approach (P5) to simulate the rolling motion of fluid-driven, particle-filled microcapsules along heterogeneous, adhesive substrates...established guidelines for designing particle-filled microcapsules that perform a “repair and go” function and could ultimately be used to restore

  15. 32 CFR 701.120 - Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA/FOIA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Privacy Program § 701.120 Processing requests that cite or imply PA, Freedom of Information (FOIA), or PA... maximum release of information allowed under the Acts. (d) Processing time limits. DON activities shall... 32 National Defense 5 2010-07-01 2010-07-01 false Processing requests that cite or imply PA...

  16. Final report on EURAMET.M.P-K4.2010: Key and supplementary comparison of national pressure standards in the range 1 Pa to 15 kPa of absolute and gauge pressure

    NASA Astrophysics Data System (ADS)

    Krajíček, Zdeněk; Bergoglio, Mercede; Jousten, Karl; Otal, Pierre; Sabuga, Wladimir; Saxholm, Sari; Pražák, Dominik; Vičar, Martin

    2014-01-01

    This report describes a EURAMET comparison of five European National Metrology Institutes in low gauge and absolute pressure in gas (nitrogen), denoted as EURAMET.M.P-K4.2010. Its main intention is to state equivalence of the pressure standards, in particular those based on the technology of force-balanced piston gauges such as e.g. FRS by Furness Controls, UK and FPG8601 by DHI-Fluke, USA. It covers the range from 1 Pa to 15 kPa, both gauge and absolute. The comparison in absolute mode serves as a EURAMET Key Comparison which can be linked to CCM.P-K4 and CCM.P-K2 via PTB. The comparison in gauge mode is a supplementary comparison. The comparison was carried out from September 2008 till October 2012. The participating laboratories were the following: CMI, INRIM, LNE, MIKES, PTB-Berlin (absolute pressure 1 kPa and below) and PTB-Braunschweig (absolute pressure 1 kPa and above and gauge pressure). CMI was the pilot laboratory and provided a transfer standard for the comparison. This transfer standard was also the laboratory standard of CMI at the same time, which resulted in a unique and logistically difficult star comparison. Both in gauge and absolute pressures all the participating institutes successfully proved their equivalence with respect to the reference value and all also proved mutual bilateral equivalences in all the points. All the participating laboratories are also equivalent with the reference values of CCM.P-K4 and CCM.P-K2 in the relevant points. The comparison also proved the ability of FPG8601 to serve as a transfer standard. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  17. PaTrx1 and PaTrx3, two cytosolic thioredoxins of the filamentous ascomycete Podospora anserina involved in sexual development and cell degeneration.

    PubMed

    Malagnac, Fabienne; Klapholz, Benjamin; Silar, Philippe

    2007-12-01

    In various organisms, thioredoxins are known to be involved in the reduction of protein disulfide bonds and in protecting the cell from oxidative stress. Genes encoding thioredoxins were found by searching the complete genome sequence of the filamentous ascomycete Podospora anserina. Among them, PaTrx1, PaTrx2, and PaTrx3 are predicted to be canonical cytosolic proteins without additional domains. Targeted disruption of PaTrx1, PaTrx2, and PaTrx3 shows that PaTrx1 is the major thioredoxin involved in sulfur metabolism. Deletions have no effect on peroxide resistance; however, data show that either PaTrx1 or PaTrx3 is necessary for sexual reproduction and for the development of the crippled growth cell degeneration (CG), processes that also required the PaMpk1 mitogen-activated protein kinase (MAPK) pathway. Since PaTrx1 PaTrx3 mutants show not an enhancement but rather an impairment in CG, it seems unlikely that PaTrx1 and PaTrx3 thioredoxins participate in the inhibition of this MAPK pathway. Altogether, these results underscore a role for thioredoxins in fungal development.

  18. A geostatistical approach to predicting sulfur content in the Pittsburgh coal bed

    USGS Publications Warehouse

    Watson, W.D.; Ruppert, L.F.; Bragg, L.J.; Tewalt, S.J.

    2001-01-01

    The US Geological Survey (USGS) is completing a national assessment of coal resources in the five top coal-producing regions in the US. Point-located data provide measurements on coal thickness and sulfur content. The sample data and their geologic interpretation represent the most regionally complete and up-to-date assessment of what is known about top-producing US coal beds. The sample data are analyzed using a combination of geologic and Geographic Information System (GIS) models to estimate tonnages and qualities of the coal beds. Traditionally, GIS practitioners use contouring to represent geographical patterns of "similar" data values. The tonnage and grade of coal resources are then assessed by using the contour lines as references for interpolation. An assessment taken to this point is only indicative of resource quantity and quality. Data users may benefit from a statistical approach that would allow them to better understand the uncertainty and limitations of the sample data. To develop a quantitative approach, geostatistics were applied to the data on coal sulfur content from samples taken in the Pittsburgh coal bed (located in the eastern US, in the southwestern part of the state of Pennsylvania, and in adjoining areas in the states of Ohio and West Virginia). Geostatistical methods that account for regional and local trends were applied to blocks 2.7 mi (4.3 km) on a side. The data and geostatistics support conclusions concerning the average sulfur content and its degree of reliability at regional- and economic-block scale over the large, contiguous part of the Pittsburgh outcrop, but not to a mine scale. To validate the method, a comparison was made with the sulfur contents in sample data taken from 53 coal mines located in the study area. The comparison showed a high degree of similarity between the sulfur content in the mine samples and the sulfur content represented by the geostatistically derived contours. Published by Elsevier Science B.V.

  19. A Simulation of High Latitude F-Layer Instabilities in the Presence of Magnetosphere-Ionosphere Coupling.

    DTIC Science & Technology

    1985-07-08

    Equatorial spread F: recent observations and a new intepretation , J. Geophys. Res., 77, 5625, 1972. Basu, S., S. Basu, E. MacKenzie, W.R. Coley, W.B. Hanson...HOPKINS ROAD LAUREL, MD 20810 DR. R. GREENWALD DR. C. MENG UNIVERSITY OF PITTSBURGH PITTSBURGH, PA 15213 DR. N. ZABUSKY DR. M. BIONDI DR. E. OVERMAN 26 FILMED 9-85 DTIC RJa. I - rlt -6 ,I, a~l O -3

  20. Remote Patient Management in a Mammographic Screening Environment in Underserved Areas

    DTIC Science & Technology

    2005-09-01

    PERFORMING ORGANIZATION NAME(S) AND ADDRESS( ES ) 8. PERFORMING ORGANIZATION REPORT NUMBER University of Pittsburgh Pittsburgh, PA 15260 9. SPONSORING...MONITORING AGENCY NAME(S) AND ADDRESS( ES ) 10. SPONSOR/MONITOR’S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012...Langer, JL Lichtenfeld, JR Osuch, LN Reynolds, ES de Paredes, RE Williams, "Responsibilities of the mammography facility," In: Quality determinants of

  1. Some Ecological Contexts of Attitudes Concerning Issues of Civil Defense.

    DTIC Science & Technology

    1983-03-01

    Urban Research AEAWOKUINMER University of Pittsburgh 48121 Pittsburgh, PA 15260 It. CONTROLLING OFFICE NAME AND ADDRESS IS. REPORT OATS March, 1983...Federal Emergency Management Agency 13. NUJMBER OF PAGES Washington, D.C. 2047227 14. MONITORING AGENCY NAME & AODRIESS(lf different 1mm Controlling ...period and prior to any Presidential action) is also quite credible (since in such a process, the individual families " control ," so to say, the time of

  2. Detection of anthrax protective antigen (PA) using europium labeled anti-PA monoclonal antibody and time-resolved fluorescence ◊

    PubMed Central

    Stoddard, Robyn A.; Quinn, Conrad P.; Schiffer, Jarad M.; Boyer, Anne E.; Goldstein, Jason; Bagarozzi, Dennis A.; Soroka, Stephen D.; Dauphin, Leslie A.; Hoffmaster, Alex R.

    2015-01-01

    Inhalation anthrax is a rare but acute infectious disease following adsorption of Bacillus anthracis spores through the lungs. The disease has a high fatality rate if untreated, but early and correct diagnosis has a significant impact on case patient recovery. The early symptoms of inhalation anthrax are, however, non-specific and current anthrax diagnostics are primarily dependent upon culture and confirmatory real-time PCR. Consequently, there may be a significant delay in diagnosis and targeted treatment. Rapid, culture-independent diagnostic tests are therefore needed, particularly in the context of a large scale emergency response. The aim of this study was to evaluate the ability of monoclonal antibodies to detect anthrax toxin proteins that are secreted early in the course of B. anthracis infection using a time-resolved fluorescence (TRF) immunoassay. We selected monoclonal antibodies that could detect protective antigen (PA), as PA83 and also PA63 and LF in the lethal toxin complex. The assay reliable detection limit (RDL) was 6.63 × 10−6 μM (0.551 ng/ml) for PA83 and 2.51 × 10−5 μM (1.58 ng/ml) for PA63. Despite variable precision and accuracy of the assay, PA was detected in 9 out of 10 sera samples from anthrax confirmed case patients with cutaneous (n=7), inhalation (n=2), and gastrointestinal (n=1) disease. Anthrax Immune Globulin (AIG), which has been used in treatment of clinical anthrax, interfered with detection of PA. This study demonstrates a culture-independent method of diagnosing anthrax through use of monoclonal antibodies to detect PA and LF in the lethal toxin complex. PMID:24857756

  3. Evaluation of ID-PaGIA syphilis antibody test.

    PubMed

    Naaber, Paul; Makoid, Ene; Aus, Anneli; Loivukene, Krista; Poder, Airi

    2009-01-01

    Laboratory diagnosis of syphilis is usually accomplished by serology. There are currently a large number of different commercial treponemal tests available that vary in format, sensitivity and specificity. To evaluate the ID-PaGIA Syphilis Antibody Test as an alternative to other specific treponemal tests for primary screening or confirmation of diagnosis. Serum samples from healthy adults (n = 100) were used for detection of specificity of ID-PaGIA. To evaluate sensitivity of ID-PaGIA serum samples (n = 101) from patients with confirmed or suspected syphilis were tested for syphilis antibodies with FTA-Abs IgM, ID-PaGIA, ELISA IgM and TPHA tests. No false-positive results were found with ID-PaGIA. Sensitivity of various treponemal tests was the following: FTA-Abs IgM: 95.5%, ID-PaGIA and ELISA IgM: 94%, and TPHA 75%. The positive and negative predictive values of ID-PaGIA were 100 and 89.5%, respectively. Compared with other treponemal tests ID-PaGIA has excellent sensitivity and specificity.

  4. 4. BASEMENT WALL BENEATH SOUTH PASSAGE SHOWING STEAM TUNNEL OPENING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. BASEMENT WALL BENEATH SOUTH PASSAGE SHOWING STEAM TUNNEL OPENING IN SOUTH WALL. - Pennsylvania Railroad Station, South Baggage Passage & Canopy, 1101 Liberty Avenue, Pittsburgh, Allegheny County, PA

  5. Building America Case Study: Evaluating Through-Wall Air Transfer Fans, Pittsburgh, Pennsylvania (Fact Sheet)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    2014-10-01

    In this project, Building America team IBACOS performed field testing in a new construction unoccupied test house in Pittsburgh, Pennsylvania to evaluate heating, ventilating, and air conditioning (HVAC) distribution systems during heating, cooling, and midseason conditions. Four air-based HVAC distribution systems were assessed:-a typical airflow ducted system to the bedrooms, a low airflow ducted system to the bedrooms, a system with transfer fans to the bedrooms, and a system with no ductwork to the bedrooms. The relative ability of each system was considered with respect to relevant Air Conditioning Contractors of America and ASHRAE standards for house temperature uniformity andmore » stability, respectively.« less

  6. PaTrx1 and PaTrx3, Two Cytosolic Thioredoxins of the Filamentous Ascomycete Podospora anserina Involved in Sexual Development and Cell Degeneration▿ †

    PubMed Central

    Malagnac, Fabienne; Klapholz, Benjamin; Silar, Philippe

    2007-01-01

    In various organisms, thioredoxins are known to be involved in the reduction of protein disulfide bonds and in protecting the cell from oxidative stress. Genes encoding thioredoxins were found by searching the complete genome sequence of the filamentous ascomycete Podospora anserina. Among them, PaTrx1, PaTrx2, and PaTrx3 are predicted to be canonical cytosolic proteins without additional domains. Targeted disruption of PaTrx1, PaTrx2, and PaTrx3 shows that PaTrx1 is the major thioredoxin involved in sulfur metabolism. Deletions have no effect on peroxide resistance; however, data show that either PaTrx1 or PaTrx3 is necessary for sexual reproduction and for the development of the crippled growth cell degeneration (CG), processes that also required the PaMpk1 mitogen-activated protein kinase (MAPK) pathway. Since PaTrx1 PaTrx3 mutants show not an enhancement but rather an impairment in CG, it seems unlikely that PaTrx1 and PaTrx3 thioredoxins participate in the inhibition of this MAPK pathway. Altogether, these results underscore a role for thioredoxins in fungal development. PMID:17933907

  7. The Pittsburgh-Based Project To Train Educational R & D Personnel. Research Training Through a Multiple System Consortium, Paper Number 1.

    ERIC Educational Resources Information Center

    Heathers, Glen

    The Learning Research and Development Center at the University of Pittsburgh, as part of a consortium of 15 educational agencies, is the prime contractor for a project to design, conduct, and diffuse training programs for educational R & D personnel. Four training programs in the areas of curriculum development and the design and conduct of local…

  8. FOREWORD: CCM Second International Seminar: Pressure Metrology from 1 kPa to 1 GPa

    NASA Astrophysics Data System (ADS)

    Molinar, G. F.

    1994-01-01

    The Comité Consultatif pour la Masse et les Grandeurs Apparentées (CCM), through its High Pressure and Medium Pressure Working Groups, organized this Second International Seminar on Pressure Metrology from 1 kPa to 1 GPa, which was held at the Laboratoire National d'Essais (LNE), Paris, France, from 2 to 4 June 1993. The scope of the seminar was to review the state of the art of pressure measurements in the 1 kPa to I GPa pressure range and to present innovative contributions by standards laboratories, universities and industry. The seminar was organized in six sessions: liquid-column manometers; piston gauge pressure standards; properties of liquids and gases relevant to pressure metrology; pressure transducers and transfer standards; pressure standard comparison (methods and results); dynamic pressure measurements. Each session opened with the presentation of a review paper on major requirements in that field and, at the end of the seminar, a general discussion was organized on the actual limits of accuracy of static and dynamic pressure measurements in fluid media, and the fundamental problems in pressure metrology between 1 kPa and 1 GPa. The seminar was attended by sixty scientists from twenty-four countries, all working in the field of pressure measurements. Forty-nine papers were presented. The participation of scientists from so many countries indicates the importance of pressure metrology from the scientific and industrial points of view. Most papers were presented by scientists from national standards laboratories, with eight papers from universities and four from industry. Eleven papers reported the results of cooperative work involving metrological institutions dealing with high pressure, generally national standards laboratories, an indication that scientific links are already well established at this level. Links are also strengthening between industry and standards laboratories. Although industrial participation at the seminar was relatively small

  9. 49. AUXILARY CHAMBER, EAST SIDE AIRLOCK LOOKING SOUTHEAST FROM INTERIOR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    49. AUXILARY CHAMBER, EAST SIDE AIRLOCK LOOKING SOUTHEAST FROM INTERIOR (LOCATION HHH) - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  10. 75 FR 75963 - Export Trade Certificate of Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ... location). The controlling entity remains the Carlyle Group, Washington, DC; Computer Sciences Corporation..., Littleton, CO; RTI International Materials Inc., has moved from Niles, OH, to Pittsburgh, PA; Science...

  11. EVALUATION OF THE CMB AND PMF MODELS USING ORGANIC MOLECULAR MARKERS IN FINE PARTICULATE MATTER COLLECTED DURING THE PITTSBURGH AIR QUALITY STUDY

    EPA Science Inventory

    This research investigated different strategies for source apportionment of airborne fine particulate matter (PM2.5) collected as part of the Pittsburgh Air Quality Study. Two source receptor models were used, the EPA Chemical Mass Balance 8.2 (CMB) and EPA Positive Matrix Facto...

  12. Variability in clinical prevalence of PaV1 in Caribbean spiny lobsters occupying commercial casitas over a large bay in Mexico.

    PubMed

    Candia-Zulbarán, Rebeca I; Briones-Fourzán, Patricia; Negrete-Soto, Fernando; Barradas-Ortiz, Cecilia; Lozano-Álvarez, Enrique

    2012-08-27

    In Bahía de la Ascensión, Mexico, the fishery for spiny lobsters Panulirus argus is based on the extensive use of casitas, large artificial shelters that can harbor the full size range of these highly gregarious lobsters. The discovery of a pathogenic virus in these lobsters (Panulirus argus virus 1, or PaV1) has raised concern about its potential effects on casita-based fisheries. Because in Bahía de la Ascensión visibly infected lobsters represent an immediate loss of revenue, we examined variability in clinical prevalence of PaV1 (percentage of lobsters visibly infected) in thousands of lobsters sampled from the commercial catch at the onset of 3 consecutive fishing years, and from 530 casitas distributed over 3 zones within the bay during 2 fishing and 2 closed seasons. In the commercial catch (lobsters 67 to 147 mm carapace length [CL]), clinical prevalence of PaV1 was low and was not affected by year or sex. In lobsters (9.2 to 115.0 mm CL) that occupied casitas, clinical prevalence of PaV1 varied with sampling season and was always higher in juveniles than in subadults or adults, but was consistently lower in one zone relative to the other 2 zones. The average clinical prevalence of PaV1 in this bay was statistically similar to the average clinical prevalence reported in Cuba, where casitas are also used, and in Florida Bay, USA, where casitas are not used. To date, PaV1 has had no discernible impact on the lobster fishery in Bahía de la Ascensión, suggesting that clinical prevalence is not influenced by the use of casitas per se.

  13. 33. FUEL HANDLING BUILDING (LOCATION A), INTERIOR LOOKING NORTH FROM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    33. FUEL HANDLING BUILDING (LOCATION A), INTERIOR LOOKING NORTH FROM ABOVE CLEAN ROOM - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  14. 50. BOILER CHAMBER No. 1, LOOKING SOUTHEAST BETWEEN CHAMBER AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    50. BOILER CHAMBER No. 1, LOOKING SOUTHEAST BETWEEN CHAMBER AND ENCLOSURE (LOCATION III) - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  15. 74. ERECTION AND WELDING OF WEST BOILER CHAMBER, DECEMBER 21, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    74. ERECTION AND WELDING OF WEST BOILER CHAMBER, DECEMBER 21, 1955 (LOOKING NORTHEAST) - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  16. 75 FR 55739 - Export Trade Certificate of Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-14

    ... Carlyle Group, Washington, DC; Computer Sciences Corporation (CSC) moved from El Segundo, CA, to Falls... Niles, OH, to Pittsburgh, PA; Science Applications International Corporation has moved from San Diego...

  17. Historic American Buildings Survey, A.S. Burns, Photographer December, 1933 HOUSE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Historic American Buildings Survey, A.S. Burns, Photographer December, 1933 HOUSE IN PENNSYLVANIA - Structures on Old National Trail, House in Pennsylvania, U.S. Route 40, Pittsburgh, Allegheny County, PA

  18. Historic American Buildings Survey, A.S. Burns, Photographer December, 1933 DETAIL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Historic American Buildings Survey, A.S. Burns, Photographer December, 1933 DETAIL OF BRIDGE IN PENNSYLVANIA - Structures on Old National Trail, Bridge, U.S. Route 40, Pittsburgh, Allegheny County, PA

  19. Simplified Space Conditioning in Low-Load Homes: Results from Pittsburgh, Pennsylvania, New Construction Unoccupied Test House

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Poerschke, A.; Stecher, D.

    2014-06-01

    Field testing was performed in a new construction unoccupied test house in Pittsburgh, Pennsylvania. Four air-based heating, ventilation, and air conditioning distribution systems--a typical airflow ducted system to the bedrooms, a low airflow ducted system to the bedrooms, a system with transfer fans to the bedrooms, and a system with no ductwork to the bedrooms--were evaluated during heating, cooling, and midseason conditions. The relative ability of each system was assessed with respect to relevant Air Conditioning Contractors of America and ASHRAE standards for house temperature uniformity and stability, respectively.

  20. Impact of National Physical Activity and Health Guidelines and Documents on Research on Teaching K-12 Physical Education in U.S.A.

    ERIC Educational Resources Information Center

    Li, Weidong; Xiang, Ping; Gao, Zan; Shen, Bo; Yin, Zhihua; Kong, Qingtao

    2016-01-01

    Purpose: This study examined the impact of published national physical activity (PA) and health guidelines, documents, and initiatives on the evolution of research on teaching K-12 physical education (PE) in U.S.A. from 1996 to October 2013. Methods: A total of 262 peer-reviewed, data-based journal articles meeting our inclusion and exclusion…

  1. 61. BOILER CHAMBER No. 2, LOOKING SOUTHWEST BETWEEN CHAMBER AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    61. BOILER CHAMBER No. 2, LOOKING SOUTHWEST BETWEEN CHAMBER AND CONCRETE ENCLOSURE (LOCATION PPP) - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  2. 72. VISITOR'S CENTER, MODEL OF BOILER CHAMBER, AUXILIARY CHAMBER, REACTOR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    72. VISITOR'S CENTER, MODEL OF BOILER CHAMBER, AUXILIARY CHAMBER, REACTOR AND CANAL (LOCATION T) - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  3. 29. MAIN CONTROL ROOM, PANELS WEST OF MAIN CONTROL AREA, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. MAIN CONTROL ROOM, PANELS WEST OF MAIN CONTROL AREA, LOOKING SOUTH (LOCATION Q) - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  4. 28. MAIN CONTROL ROOM, PANELS WEST OF MAIN CONTROL AREA, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. MAIN CONTROL ROOM, PANELS WEST OF MAIN CONTROL AREA, LOOKING NORTH (LOCATION Q) - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  5. 20. Jack E. Boucher, Photogtapher, May 1974. CLOSEUP VIEW OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. Jack E. Boucher, Photogtapher, May 1974. CLOSE-UP VIEW OF PAULI-LENTICULAR TRUSS SYSTEM, CENTRAL AREA. - Smithfield Street Bridge, Spanning Monongahela River on Smithfield Street, Pittsburgh, Allegheny County, PA

  6. Looking south at a chemical mixing tank for boiler feedwater. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking south at a chemical mixing tank for boiler feedwater. - Wheeling-Pittsburgh Steel Corporation, Allenport Works, Boiler House, Route 88 on West bank of Monongahela River, Allenport, Washington County, PA

  7. 6. VIEW NORTH, LOWER STATION EAST SIDE. Monongahela Incline ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. VIEW NORTH, LOWER STATION EAST SIDE. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  8. 3. INCLINE PLANE CAR INTERIOR, UPPER COMPARTMENT. Monongahela Incline ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. INCLINE PLANE CAR INTERIOR, UPPER COMPARTMENT. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  9. 26. UPPER STATION, LOWER FLOOR, BULL WHEEL. Monongahela Incline ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. UPPER STATION, LOWER FLOOR, BULL WHEEL. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  10. VIEW FROM CHARGING FLOOR LOOKING EAST AT COAL HOPPER, AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW FROM CHARGING FLOOR LOOKING EAST AT COAL HOPPER, AND PHYSICAL REMAINS OF GAS PRODUCER SYSTEM. - Pittsburgh Steel Company, Monessen Works, Open Hearth Plant, Donner Avenue, Monessen, Westmoreland County, PA

  11. New Insights on Visual Cortex. Abstracts. Center for Visual Science Symposium (16th) Held in Rochester, New York on June 16-18, 1988

    DTIC Science & Technology

    1988-06-01

    Cortex of the Cat John G. Robson Craik Physiological Laboratory Cambridge University Cambridge, England When tested with spatially-localized stimuli...University, New York, NY Stanley Klein - School of Optometry, University Berkeley, Berkeley, CA Jennifer Knight - Neurobiology & Behavior, Cornell University...Village, Poughkeepsie, NY Jeffrcy Lubin - Psychology Department, University of PA, Philadelphia, PA Jennifer S. Lund - University of Pittsburgh

  12. 55. BOILER CHAMBER No. 1, LOOP B, STEAM DRUM AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    55. BOILER CHAMBER No. 1, LOOP B, STEAM DRUM AND DOWNCOMERS LOOKING EAST (LOCATION LLL) - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  13. 66. TURBINE BUILDING (LOCATION N), FIRST LEVEL, B AND D ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    66. TURBINE BUILDING (LOCATION N), FIRST LEVEL, B AND D LOOP STEAM HEATERS FROM NORTH - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  14. 67. TURBINE BUILDING (LOCATION N), FIRST LEVEL, B AND D ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    67. TURBINE BUILDING (LOCATION N), FIRST LEVEL, B AND D LOOP STEAM HEATERS FROM NORTHWEST - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  15. 63. REACTOR CHAMBER (BASF) FROM NORTH SHOWING NEUTRON SHIELD TANK ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    63. REACTOR CHAMBER (BASF) FROM NORTH SHOWING NEUTRON SHIELD TANK AND REACTOR PIPING (LOCATION RRR) - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  16. 19. Jack E, Boucher, Photographer, May 1974. CLOSEUP DETAIL VIEW ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. Jack E, Boucher, Photographer, May 1974. CLOSE-UP DETAIL VIEW OF PAULI-LENTICULAR TRUSS SYSTEM, CENTRAL AREA. - Smithfield Street Bridge, Spanning Monongahela River on Smithfield Street, Pittsburgh, Allegheny County, PA

  17. 16. UPPER STATION, WEST FACADE, LOOKING EAST SOUTHEAST. Monongahela ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. UPPER STATION, WEST FACADE, LOOKING EAST SOUTHEAST. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  18. 120. COOLANT LINES TO SIS HEAT EXCHANGER No.1 IN AUXILIARY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    120. COOLANT LINES TO SIS HEAT EXCHANGER No.1 IN AUXILIARY CHAMBER, NOVEMBER 1, 1976 - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  19. 124. TV MESSAGE FROM WHITE HOUSE AUTHORIZING LWBR POWER INCREASE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    124. TV MESSAGE FROM WHITE HOUSE AUTHORIZING LWBR POWER INCREASE TO 100%, DECEMBER 2, 1977 - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  20. VIEW FACING EAST LOOKING DOWN FROM OPEN HEARTH TAPPING FLOOR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW FACING EAST LOOKING DOWN FROM OPEN HEARTH TAPPING FLOOR AREA, NOTE FOUNDATIONS OF OPEN HEARTH FURNACES. - Pittsburgh Steel Company, Monessen Works, Open Hearth Plant, Donner Avenue, Monessen, Westmoreland County, PA

  1. Looking north at the stokers for boilers numbers 1 through ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking north at the stokers for boilers numbers 1 through 4. - Wheeling-Pittsburgh Steel Corporation, Allenport Works, Boiler House, Route 88 on West bank of Monongahela River, Allenport, Washington County, PA

  2. 33 CFR 72.01-25 - Marine broadcast notice to mariners.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Geospatial-Intelligence Agency Publication 117) and United States Coast Pilots. (b) Any person may purchase.... Government Printing Office, Superintendent of Documents, P.O. Box 371954, Pittsburgh, PA 15250-1954. (c) Any...

  3. 480mm telephoto perspective, looking south toward midspan and south anchor ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    480-mm telephoto perspective, looking south toward mid-span and south anchor arm. - Pittsburgh & Lake Erie Railroad, Ohio River Bridge, Spanning Ohio River, West of Beaver River, Beaver, Beaver County, PA

  4. 480mm telephoto perpective, looking south toward midspan and south anchor ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    480-mm telephoto perpective, looking south toward mid-span and south anchor arm. - Pittsburgh & Lake Erie Railroad, Ohio River Bridge, Spanning Ohio River, West of Beaver River, Beaver, Beaver County, PA

  5. What are the factors associated with physical activity (PA) participation in community dwelling adults with dementia? A systematic review of PA correlates.

    PubMed

    Stubbs, Brendon; Eggermont, Laura; Soundy, Andrew; Probst, Michel; Vandenbulcke, Mathieu; Vancampfort, Davy

    2014-01-01

    PA shows promise as a modifiable lifestyle intervention to benefit pathological symptoms of dementia. However, little is known about the factors associated with participation in PA in community dwelling adults with dementia. A systematic review was undertaken to identify PA correlates. Two independent reviewers searched major electronic databases and extracted data on studies reporting quantitative correlates of PA participation in community dwelling adults with dementia. PA correlates were analyzed using the summary code approach within the socio-ecological model. Out of a potential of 118 articles, 12 met the eligibility criteria encompassing 752 participants. We conducted secondary analysis on nine data sets. Increased energy intake, resting metabolic rate, fat free mass, gait speed, global motor function, overall health related quality of life (HRQOL), physical HRQOL, higher levels of social functioning and reduced apathy were positively associated with PA. Taking ≥ four medications, dizziness, lower activities of daily living (ADL) function, a history of falls, less waking hours in the day, more autonomic problems and delirium were negatively associated with PA. Increasing age and lower global cognition were not consistently associated with PA participation. It is surprising that increasing age and lower global cognition do not appear to influence PA participation. All significant correlates should be confirmed in prospective studies with particular focus on the relationship of PA and gait speed, ADL function, falls history and dietary intake and the progression of frailty and nursing home admission as a priority. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  6. Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics.

    PubMed

    Baba, Takashi; Kashiwagi, Yuriko; Arimitsu, Nagisa; Kogure, Takeshi; Edo, Ayumi; Maruyama, Tomohiro; Nakao, Kazuki; Nakanishi, Hiroki; Kinoshita, Makoto; Frohman, Michael A; Yamamoto, Akitsugu; Tani, Katsuko

    2014-04-18

    Recent studies have suggested that phosphatidic acid (PA), a cone-shaped phospholipid that can generate negative curvature of lipid membranes, participates in mitochondrial fusion. However, precise mechanisms underling the production and consumption of PA on the mitochondrial surface are not fully understood. Phosphatidic acid-preferring phospholipase A1 (PA-PLA1)/DDHD1 is the first identified intracellular phospholipase A1 and preferentially hydrolyzes PA in vitro. Its cellular and physiological functions have not been elucidated. In this study, we show that PA-PLA1 regulates mitochondrial dynamics. PA-PLA1, when ectopically expressed in HeLa cells, induced mitochondrial fragmentation, whereas its depletion caused mitochondrial elongation. The effects of PA-PLA1 on mitochondrial morphology appear to counteract those of MitoPLD, a mitochondrion-localized phospholipase D that produces PA from cardiolipin. Consistent with high levels of expression of PA-PLA1 in testis, PA-PLA1 knock-out mice have a defect in sperm formation. In PA-PLA1-deficient sperm, the mitochondrial structure is disorganized, and an abnormal gap structure exists between the middle and principal pieces. A flagellum is bent at that position, leading to a loss of motility. Our results suggest a possible mechanism of PA regulation of the mitochondrial membrane and demonstrate an in vivo function of PA-PLA1 in the organization of mitochondria during spermiogenesis.

  7. Creating an infrastructure for training in the responsible conduct of research: the University of Pittsburgh's experience.

    PubMed

    Barnes, Barbara E; Friedman, Charles P; Rosenberg, Jerome L; Russell, Joanne; Beedle, Ari; Levine, Arthur S

    2006-02-01

    In response to public concerns about the consequences of research misconduct, academic institutions have become increasingly cognizant of the need to implement comprehensive, effective training in the responsible conduct of research (RCR) for faculty, staff, students, and external collaborators. The ability to meet this imperative is challenging as universities confront declining financial resources and increasing complexity of the research enterprise. The authors describe the University of Pittsburgh's design, implementation, and evaluation of a Web-based, institution-wide RCR training program called Research and Practice Fundamentals (RPF). This project, established in 2000, was embedded in the philosophy, organizational structure, and technology developed through the Integrated Advanced Information Management Systems grant from the National Library of Medicine. Utilizing a centralized, comprehensive approach, the RPF system provides an efficient mechanism for deploying content to a large, diverse cohort of learners and supports the needs of research administrators by providing access to information about who has successfully completed the training. During its first 3 years of operation, the RPF served over 17,000 users and issued more than 38,000 training certificates. The 18 modules that are currently available address issues required by regulatory mandates and other content areas important to the research community. RPF users report high levels of satisfaction with content and ease of using the system. Future efforts must explore methods to integrate non-RCR education and training into a centralized, cohesive structure. The University of Pittsburgh's experience with the RPF demonstrates the importance of developing an infrastructure for training that is comprehensive, scalable, reliable, centralized, affordable, and sustainable.

  8. 48. AUXILIARY CHAMBER (EAST END), VIEW LOOKING EAST SHOWING ELECTRICAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    48. AUXILIARY CHAMBER (EAST END), VIEW LOOKING EAST SHOWING ELECTRICAL PENETRATION AND AIR LOCK (LOCATION GGG) - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  9. 41. AUXILIARY CHAMBER, CONCRETE ENCLOSURE CHAMBER AIR LOCK (EXTERIOR), LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    41. AUXILIARY CHAMBER, CONCRETE ENCLOSURE CHAMBER AIR LOCK (EXTERIOR), LOOKING NORTHEAST FROM SOUTHWEST CORNER (LOCATION AAA) - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  10. 4. VIEW LOOKING NORTHWEST OF FUEL HANDLING BUILDING (CENTER), REACTOR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. VIEW LOOKING NORTHWEST OF FUEL HANDLING BUILDING (CENTER), REACTOR SERVICE BUILDING (RIGHT), MACHINE SHOP (LEFT) - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  11. 7. LOWER STATION, FIRST FLOOR, WAITING ROOM, LOOKING EAST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. LOWER STATION, FIRST FLOOR, WAITING ROOM, LOOKING EAST. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  12. 14. UPPER STATION, FRONT AND WEST FACADES, LOOKING NORTHEAST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. UPPER STATION, FRONT AND WEST FACADES, LOOKING NORTHEAST. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  13. 15. UPPER STATION, FRONT AND EAST FACADES, LOOKING NORTH. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. UPPER STATION, FRONT AND EAST FACADES, LOOKING NORTH. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  14. 20. UPPER STATION, LOWER FLOOR, MOTOR ROOM, SWITCHING PANEL. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. UPPER STATION, LOWER FLOOR, MOTOR ROOM, SWITCHING PANEL. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  15. 25. UPPER STATION, LOWER FLOOR, MOTOR ROOM, GOVERNOR SWITCH. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    25. UPPER STATION, LOWER FLOOR, MOTOR ROOM, GOVERNOR SWITCH. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  16. Recombinant α1-Antitrypsin Pittsburgh Attenuates Experimental Gram-Negative Septicemia

    PubMed Central

    Colman, Robert W.; Flores, Daniel N.; De La Cadena, Raul A.; Scott, Cheryl F.; Cousens, Laurence; Barr, Philip J.; Hoffman, Ian B.; Kueppers, Friedrich; Fisher, Donald; Idell, Steven; Pisarello, Jorge

    1988-01-01

    Alpha1-antitrypsin-Pittsburgh (AT-P), a naturally occurring lethal mutation (358Met → Arg), has been genetically engineered (rAT-P). The protein has been shown to be a potent active site-directed inhibitor of thrombin and the contact enzymes Factor XIIf, Factor XIa, and kallikrein. Because activation of the contact system is known to occur in gram-negative septicemia, the authors have hypothesized that the administration of rAT-P might modulate the course of this syndrome. Yorkshire piglets anesthetized with pentobarbital and infused with viable Pseudomonas aeruginosa (2 X 108 CFU) were untreated (Group I) or treated with rAT-P (Group II) and studied in a 6-hour protocol. Coagulation studies revealed that rAT-P significantly inhibited the rapid decrease in the functional concentrations of Antithrombin III, Factor XI, and fibrinogen. In addition, rAT-P markedly reduced the serum levels of fibrinogen degradation products. Survival in Group II was significantly increased during 2-5 hours but not at 6 hours when the functional levels of rAT-P in plasma were the lowest. These results indicate that this recombinant inhibitor, even at low concentrations, affords protection in experimental gram-negative septicemia. PMID:3257651

  17. Constitutional Law--State Action--Hiring and Promotion Practices of Private University Receiving Public Funds Held State Action--Braden v. University of Pittsburgh.

    ERIC Educational Resources Information Center

    New York University Law Review, 1977

    1977-01-01

    In Braden vs University of Pittsburgh, a female professor filed suit against the University alleging sex discrimination in employment practices. The professor alleged that the school, which received state funds, was, in effect, a state actor and subject to constitutional restraints. This case and two relevant state action cases are discussed. (JMD)

  18. 60. BOILER CHAMBER No. 1, D LOOP STEAM GENERATOR AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    60. BOILER CHAMBER No. 1, D LOOP STEAM GENERATOR AND MAIN COOLANT PUMP LOOKING NORTHEAST (LOCATION OOO) - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  19. 42. AUXILIARY CHAMBER, VIEW LOOKING EAST FROM WEST END, OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    42. AUXILIARY CHAMBER, VIEW LOOKING EAST FROM WEST END, OF AUXILIARY PIPING, STEAM, FEEDWATER PIPING (LOCATION BBB) - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  20. 17. UPPER STATION, FIRST FLOOR, WAITING ROOM, LOOKING WEST, NORTHWEST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. UPPER STATION, FIRST FLOOR, WAITING ROOM, LOOKING WEST, NORTHWEST. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  1. 18. UPPER STATION, FIRST FLOOR, OPERATOR'S CABIN, LOOKING NORTH, NORTHEAST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. UPPER STATION, FIRST FLOOR, OPERATOR'S CABIN, LOOKING NORTH, NORTHEAST. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  2. 27. UPPER STATION, LOWER FLOOR, BULL WHEEL, BRAKE AIR CYLINDER. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    27. UPPER STATION, LOWER FLOOR, BULL WHEEL, BRAKE AIR CYLINDER. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  3. 3. INTERIOR OF SOUTHEAST CORNER OF OPEN CONCOURSE, SHOWING WOODFRAMED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. INTERIOR OF SOUTHEAST CORNER OF OPEN CONCOURSE, SHOWING WOOD-FRAMED WINDOWS AND CEMENTED TILE AND STEEL CEILING - Pennsylvania Railroad Station, Open Concourse & Concourse Roof Extension, 1101 Liberty Avenue, Pittsburgh, Allegheny County, PA

  4. Looking south at the ash disposal hoppers for boilers numbers ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking south at the ash disposal hoppers for boilers numbers 1 through 6. - Wheeling-Pittsburgh Steel Corporation, Allenport Works, Boiler House, Route 88 on West bank of Monongahela River, Allenport, Washington County, PA

  5. Historic American Buildings Survey, A.S. Burns, Photographer December, 1933 TOLL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Historic American Buildings Survey, A.S. Burns, Photographer December, 1933 TOLL HOUSE (DETAIL OF PLAQUE SHOWING TOLL RATES) - Structures on Old National Trail, Toll House, U.S. Route 40, Pittsburgh, Allegheny County, PA

  6. 44. AUXILIARY CHAMBER BETWEEN CHAMBER AND CONCRETE ENCLOSURE (LOCATION CCC), ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    44. AUXILIARY CHAMBER BETWEEN CHAMBER AND CONCRETE ENCLOSURE (LOCATION CCC), LOOKING NORTHEAST SHOWING DRAIN PIPE FROM SUMP - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  7. TRUST-tPA trial: Telemedicine for remote collaboration with urgentists for stroke-tPA treatment.

    PubMed

    Mazighi, Mikael; Meseguer, Elena; Labreuche, Julien; Miroux, Patrick; Le Gall, Catherine; Roy, Patricia; Tubach, Florence; Amarenco, Pierre

    2017-01-01

    Background Previous observational studies have shown that telemedicine is feasible and safe to deliver intravenous (IV) recombinant tissue plasminogen activator (rt-PA). However, implementation of telemedicine may be challenging. To illustrate this fact, we report a study showing that telemedicine failed to improve clinical outcome and analyze the reasons for this shortcoming. Methods We established a tele-stroke network of 10 emergency rooms (ERs) of community hospitals connected to a stroke center to perform a randomized, open-label clinical trial with blinded outcome evaluation. Eligible patients were randomly assigned to either a usual care arm (i.e. immediate transfer to the stroke center and administration of IV rt-PA if indication was confirmed upon stroke arrival) or tele-thrombolysis arm (i.e. immediate administration of IV rt-PA in ER and transfer to the stroke center). The primary efficacy outcome was an excellent outcome (modified Rankin scale (mRS) 0-1 at 90 days). Secondary endpoints included favorable outcome (90-day mRS 0-2) and early neurological improvement (NIHSS score 0-1 at 24 hours or a decrease of ≥ 4 points within 24 hours). Safety outcomes included symptomatic intracerebral hemorrhage (ICH) per ECASS II definition, any ICH and all-cause mortality. Results During an accrual time of 48 months, because of a slow enrollment rate, only 49 of 270 patients initially planned for inclusion were randomized into usual care ( n = 23) and tele-thrombolysis ( n = 26). Despite random assignment, patients allocated to tele-thrombolysis were older and had more severe stroke than patients allocated to usual care. The median duration of video-conference was 23 minutes in the usual care arm and 73 minutes in the tele-thrombolysis arm. Eighty-four percent of patients in the tele-thrombolysis arm were treated by IV rt-PA in comparison to 18% in the usual care arm. In univariate analysis but not after adjustment for age and baseline NIHSS, patients

  8. Cross-cultural adaptation of the assistive technology device - Predisposition assessment (ATD PA) for use in Brazil (ATD PA Br).

    PubMed

    Alves, Ana Cristina de Jesus; Matsukura, Thelma Simões; Scherer, Marcia J

    2017-02-01

    The purpose of this study is to conduct a cross-cultural adaptation of the Assistive Technology Device Predisposition Assessment (ATD PA) for use in Brazil. The selection of the Assistive Technology Device Predisposition Assessment (ATD PA) was determined by previous literature reviews of articles published in 2014 and 2016 in six databases with the terms "assistive device" or "assistive technology" or "self-help device" combined with "evidence-based practice" or "framework" or "measurement scale" or "model and outcome assessment". This review indicated that the conceptual model of Assistive Technology (AT) most discussed in the literature was the Matching Person and Technology (MPT) model, and this finding determined the selection of ATD PA as an assessment within the MPT portfolio of measures. The procedures for cross-cultural adaptation were as follows: Equivalence of Concept, Semantic and Operational. Five experts were asked to translate 725 items and these translations were evaluated and a high level of agreement was demonstrated. The Portuguese version, Avaliação de Tecnologia Assistiva - Predisposição ao Uso - ATD PA Br, was derived from the original version in English (ATD PA). The ATD PA Br will support professionals and people with disabilities in Brazil to better select AT devices according to the clients' needs. Implications for rehabilitation Provides a systematic way of selecting assistive technology devices for the use of individuals with disabilities according to the Brazilian reality. A systematic way of selecting the assistive technology that can help decrease the abandonment of the assistive technology use. The use of the Matching Person and Technology theorical model and of the assessment ATD PA Br is essential to guide the researches and clinical practice in Brazil.

  9. 69. TURBINE BUILDING (LOCATION N), THIRD LEVEL LOOKING NORTHWEST SHOWING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    69. TURBINE BUILDING (LOCATION N), THIRD LEVEL LOOKING NORTHWEST SHOWING BASE OF CONDENSOR AND RIVER WATER OUTLET PIPE - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  10. 4. VIEW SOUTHWEST, LOWER STATION FRONT, INCLINE PLANE TRACK, UPPER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. VIEW SOUTHWEST, LOWER STATION FRONT, INCLINE PLANE TRACK, UPPER STATION. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  11. 5. VIEW SOUTHWEST, LOWER STATION FRONT, INCLINE PLANE TRACK, UPPER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. VIEW SOUTHWEST, LOWER STATION FRONT, INCLINE PLANE TRACK, UPPER STATION. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  12. 22. UPPER STATION, LOWER FLOOR, MOTOR ROOM, VERTICAL DEFLECTOR SHEAVE, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. UPPER STATION, LOWER FLOOR, MOTOR ROOM, VERTICAL DEFLECTOR SHEAVE, MOTORS. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  13. 23. UPPER STATION, LOWER FLOOR, MOTOR ROOM, VERTICAL DEFLECTOR SHEAVE, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. UPPER STATION, LOWER FLOOR, MOTOR ROOM, VERTICAL DEFLECTOR SHEAVE, MOTORS. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  14. 2. VIEW SOUTH, INCLINE PLANE CAR, INCLINE PLANE TRACK, UPPER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. VIEW SOUTH, INCLINE PLANE CAR, INCLINE PLANE TRACK, UPPER STATION. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  15. 78 FR 20948 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Network Centric...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-08

    ...; and Software Engineering Institute/CMU, Pittsburgh, PA, have withdrawn as parties to this venture. No... Section 6(b) of the Act on October 18, 2012 (77 FR 64128). Patricia A. Brink, Director of Civil...

  16. 12. CAPSTANS OF FRONT DECK. MIDDLE DOOR IS OPEN. ALL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. CAPSTANS OF FRONT DECK. MIDDLE DOOR IS OPEN. ALL DOORS COULD OPEN, TO GIVE OPERATOR AN UNIMPEDED VIEW. - Dredge CINCINNATI, Docked on Ohio River at foot of Lighthill Street, Pittsburgh, Allegheny County, PA

  17. Annual Report: Unconventional Fossil Energy Resource Program (30 September 2013)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Soong, Yee; Guthrie, George

    2013-09-30

    Yee Soong, Technical Coordinator, George Guthrie, Focus Area Lead, UFER Annual Report, NETL-TRS-UFER-2013, NETL Technical Report Series, U.S. Department of Energy, National Energy Technology Laboratory, Pittsburgh, PA, 2013, p 14.

  18. Looking southeast at coal conveyor leading from the coal unloading ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking southeast at coal conveyor leading from the coal unloading station to the coal elevator. - Wheeling-Pittsburgh Steel Corporation, Allenport Works, Boiler House, Route 88 on West bank of Monongahela River, Allenport, Washington County, PA

  19. 21. UPPER STATION, LOWER FLOOR, MOTOR ROOM, SWITCHING PANEL, ELECTRICAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. UPPER STATION, LOWER FLOOR, MOTOR ROOM, SWITCHING PANEL, ELECTRICAL POWER ENTRY. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  20. 35. FUEL HANDLING BUILDING, INTERIOR LOOKING SOUTHEAST SHOWING TRANSFER CANAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    35. FUEL HANDLING BUILDING, INTERIOR LOOKING SOUTHEAST SHOWING TRANSFER CANAL AREA, DEEP STORAGE AREA, FUEL STORAGE PIT (LOCATION BB) - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  1. 3. INTERIOR OF SOUTH BAGGAGE PASSAGE LOOKING EAST, SHOWING ROOF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. INTERIOR OF SOUTH BAGGAGE PASSAGE LOOKING EAST, SHOWING ROOF OF WOOD, GLASS, AND STEEL (TARRED ON EXTERIOR, PAINTED ON INTERIOR) - Pennsylvania Railroad Station, South Baggage Passage & Canopy, 1101 Liberty Avenue, Pittsburgh, Allegheny County, PA

  2. 11. LOWER STATION, SECOND FLOOR, BOARD OF DIRECTORS' MEETING ROOM. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. LOWER STATION, SECOND FLOOR, BOARD OF DIRECTORS' MEETING ROOM. LOOKING NORTH. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  3. 28. UPPER STATION, LOWER FLOOR, BULL WHEEL ROOM, SAFETY BRAKE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. UPPER STATION, LOWER FLOOR, BULL WHEEL ROOM, SAFETY BRAKE ADJUSTING MACHINERY. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  4. 1. VIEW WEST SOUTHWEST, UPPER STATION. INCLINE PLANE TRACK AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. VIEW WEST SOUTHWEST, UPPER STATION. INCLINE PLANE TRACK AND LOWER STATION. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  5. LONGITUDINAL VIEW OF THE SOAKING PIT BUILDING INTERIOR WITH OPEN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    LONGITUDINAL VIEW OF THE SOAKING PIT BUILDING INTERIOR WITH OPEN HEARTH IN BACKGROUND AND FURNACE PIT/ STACK AREA TO THE LEFT. - Pittsburgh Steel Company, Monessen Works, Open Hearth Plant, Donner Avenue, Monessen, Westmoreland County, PA

  6. Looking southwest at the motor, drive shaft, and stokers for ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking southwest at the motor, drive shaft, and stokers for boilers numbers 1 through 6. - Wheeling-Pittsburgh Steel Corporation, Allenport Works, Boiler House, Route 88 on West bank of Monongahela River, Allenport, Washington County, PA

  7. 4th floor sacking deck looking east from 1945 elevator to ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4th floor sacking deck looking east from 1945 elevator to 1913 elevator indicating spout used to load bulk grain into rail cars - Stewart Company Grain Elevator, 16 West Carson Street, Pittsburgh, Allegheny County, PA

  8. PERSPECTIVE VIEW FROM SOUTHWEST OF THE ALCOA BUILDING, A WELLKNOWN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PERSPECTIVE VIEW FROM SOUTHWEST OF THE ALCOA BUILDING, A WELL-KNOWN POST-WAR CORPORATE SKYSCRAPER BUILT IN 1953 AND DESIGNED BY THE FIRM OF HARRISON AND ABRAMOVITZ. - ALCOA Building, 425 Sixth Avenue, Pittsburgh, Allegheny County, PA

  9. 10. LOWER STATION, FIRST FLOOR, INCLINE PLANE TRCK LOOKING SOUTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. LOWER STATION, FIRST FLOOR, INCLINE PLANE TRCK LOOKING SOUTH SOUTHEAST, UPPER STATION. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  10. VIEW LOOKING WEST DOWN TRACKS WITH OPEN HEARTH ON THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW LOOKING WEST DOWN TRACKS WITH OPEN HEARTH ON THE RIGHT FOREGROUND AND BRICK POWER HOUSE TO LEFT, BLOOMING MILL IN BACKGROUND. - Pittsburgh Steel Company, Monessen Works, Open Hearth Plant, Donner Avenue, Monessen, Westmoreland County, PA

  11. 76 FR 72673 - Foreign-Trade Zone 33-Pittsburgh, PA; Application for Reorganization/Expansion

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-25

    ... submitted pursuant to the provisions of the Foreign-Trade Zones Act, as amended (19 U.S.C. 81a-81u), and the... (new site acreage--698 acres); (7) modify Site 14 by deleting 6.5 acres (new site acreage--68 acres...

  12. POLLUTION PREVENTION OPPORTUNITY ASSESSMENT - U.S. POSTAL SERVICE POST OFFICES, PITTSBURGH, PA AREA

    EPA Science Inventory

    The United States Postal Service (USPS) in cooperation with EPA’s National Risk Management Research Laboratory (NRMRL) is engaged in an effort to integrate waste prevention and recycling activities into the waste management programs at Postal facilities. This report describ...

  13. [Tumor-associated prognostic factors of the plasminogen activator family: determination and clinical value of u-PA, t-PA, PAI-1, and PAI-2].

    PubMed

    Mengele, K; Harbeck, N; Reuning, U; Magdolen, V; Schmitt, M

    2005-08-01

    Proteolytic factors belonging t the plasminogen activator family (plasmin, u-PA, t-PA, u-PAR, PAI-1, and PAI-2), which usually are involved in blood clotting and degradation of blood clots, are also present in healthy and diseased tissue of the kidney, lung, liver, gastro-intestinal tract, breast, prostate, ovary, and brain. These factors are engaged in brain development, angiogenesis and vascular invasion, wound healing as well as in placenta development and embryogenesis. Plasminogen activators u-PA and t-PA, their inhibitors PAI-1 and PAI-2, and the u-PA-receptor (u-PAR, CD87) are often elevated in solid malignant tumour tissues compared to their normal counterparts. In breast cancer patients, an elevated tumour tissue extract antigen content of u-PA, PAI-1, and u-PAR is associated with increased tumour aggressiveness and poor prognosis; in contrary, an elevated content of t-PA and PAI-2 indicates a favourable prognosis. For clinical relevant determination of these proteolytic factors in tumour tissue extracts, only enzymo-immunometric tests (ELISA) are recommended. Enzymometric and enzymographic tests are actually conducted only in an experimental, preclinical context.

  14. Control Charts When the Observations Are Correlated.

    DTIC Science & Technology

    1987-05-01

    l7 D-AiB6 388 CONTROL CHARTS WHEN THE OBSERVATIONS ARE CORRELATED(J) i/iPITTSBURGH UNIV PA CENTER FOR KULTIVARIATE ANALYSIS P R KRISHNAIAH ET AL MAY... Krishnaiah and B. Q. Miao F-49620-85-C-0008 S. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT. PROJECT. TASK AREA II WORK UNIT NUMBERS... Krishnaiah and B.Q. Miao Center for Multivariate Analysis University of Pittsburgh N DTIC E L 1Zk-, -I- OCT0 11987 Play 1987 Technical Report No. 87-09

  15. Csk Homologous Kinase, a Potential Regulator of CXCR4-Medicated Breast Cancer Cell Metastasis

    DTIC Science & Technology

    2011-08-01

    is a non-receptor tyrosine kinase and a second member of the Csk family. Like Csk, CHK has Src homology 2 ( SH2 ) and SH3 domains and lacks the...MSCV-retroviral vectors encoding either wild-type CHK or kinase -dead CHK or wild type SH2 domain or SH2 -R147A or SH2 -G129A. All these constructs were... Kinase , a Potential Regulator of CXCR4-Medicated Breast Cancer Cell Metastasis Byeong-Chel Lee The University of Pittsburgh Pittsburgh, PA 15213

  16. Observations of 231Pa/ 235U disequilibrium in volcanic rocks

    NASA Astrophysics Data System (ADS)

    Pickett, David A.; Murrell, Michael T.

    1997-04-01

    We present here the first survey of ( 231Pa/ 235U) ratios in volcanic rocks; such measurements are made possible by new mass spectrometric techniques. The data place new constraints on the timing and extent of magma source and evolutionary processes, particularly due to the sensitivity of the 231Pa- 235U pair and its intermediate time scale ( 231Pat 1/2 = 33 ky). ( 231Pa/ 235U) is found to vary widely, from 0.2 in carbonatites to 1.1-2.9 in basalts and 0.9-2.2 in arcs. Substantial Pa enrichment is nearly ubiquitous, suggestive of the relative incompatibility of Pa, qualitatively consistent with available partitioning data. The level of 231Pa- 235U disequilibrium typically far exceeds that of 230Th- 238U and is comparable to 226Ra- 230Th. The high ( 231Pa/ 235U) ratios in MORB and other basalts reflect a large degree of discrimination between two incompatible elements, posing challenges for modelling of melt generation and migration. Fundamental differences in ( 231Pa/ 235U) among different basaltic environments are likely related to contrasts in melting zone conditions (e.g., melting rate). Strong ( 231Pa/ 235U) disequilibria in continental basalts, for which ( 230Th/ 238U) disequilibria are small or absent, demonstrate that Pa-U fractionation is possible in both garnet and spinel mantle stability fields. In arcs, correlation of ( 231Pa/ 235U) and ( 230Th/ 238U) is consistent with U enrichment via slab-derived fluids, a process which is additional to the still dominant Pa enrichment. An important new constraint is provided by the observation that the near-equilibrium ( 230Th/ 238U) common to arcs and continental basalts is not typically accompanied by near-equilibrium ( 231Pa/ 235U), arguing against the influence of long magma history, crustal material, or equilibrium mantle sources in affecting decay-series ratios. Small sample sets from two silicic centers illustrate: (1) recent, rapid U enrichment in the magma chamber (El Chichón); and (2) the failure of

  17. 46. AUXILIARY CHAMBER (EAST END), LOOKING NORTHWEST AT STEAM AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    46. AUXILIARY CHAMBER (EAST END), LOOKING NORTHWEST AT STEAM AND FEEDWATER PIPING AND PRESSURIZER AND FLASH/BLOWOFF TANK ROOMS (LOCATION EEE) - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  18. 12. LOWER STATION, SECOND FLOOR, BOARD OF DIRECTORS' MEETING ROOM, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. LOWER STATION, SECOND FLOOR, BOARD OF DIRECTORS' MEETING ROOM, NORTHWEST WALL. FIREPLACE DETAIL. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  19. 19. UPPER STATION, FIRST FLOOR, OPERATOR'S CABIN, DOORS TO INCLINE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. UPPER STATION, FIRST FLOOR, OPERATOR'S CABIN, DOORS TO INCLINE PLANE CARS, LOOKING WEST. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  20. The Online Bioinformatics Resources Collection at the University of Pittsburgh Health Sciences Library System--a one-stop gateway to online bioinformatics databases and software tools.

    PubMed

    Chen, Yi-Bu; Chattopadhyay, Ansuman; Bergen, Phillip; Gadd, Cynthia; Tannery, Nancy

    2007-01-01

    To bridge the gap between the rising information needs of biological and medical researchers and the rapidly growing number of online bioinformatics resources, we have created the Online Bioinformatics Resources Collection (OBRC) at the Health Sciences Library System (HSLS) at the University of Pittsburgh. The OBRC, containing 1542 major online bioinformatics databases and software tools, was constructed using the HSLS content management system built on the Zope Web application server. To enhance the output of search results, we further implemented the Vivísimo Clustering Engine, which automatically organizes the search results into categories created dynamically based on the textual information of the retrieved records. As the largest online collection of its kind and the only one with advanced search results clustering, OBRC is aimed at becoming a one-stop guided information gateway to the major bioinformatics databases and software tools on the Web. OBRC is available at the University of Pittsburgh's HSLS Web site (http://www.hsls.pitt.edu/guides/genetics/obrc).

  1. The PA influenza virus polymerase subunit is a phosphorylated protein.

    PubMed

    Sanz-Ezquerro, J J; Fernández Santarén, J; Sierra, T; Aragón, T; Ortega, J; Ortín, J; Smith, G L; Nieto, A

    1998-03-01

    The induction of proteolysis by expression of the influenza virus PA polymerase subunit is the only biochemical activity ascribed to this protein. In the course of studying viral protein synthesis by two-dimensional gel electrophoresis, we observed the existence of several PA isoforms with different isoelectric points. These isoforms were also present when the PA gene was singly expressed in three different expression systems, indicating that a cellular activity is responsible for its post-translational modification. In vivo labelling with [32P]orthophosphate, followed by two-dimensional gel electrophoresis, clearly demonstrated the incorporation of phosphate into the PA molecule. Phosphoserine and phosphothreonine epitopes were present in PA, while phosphotyrosine residues were absent, as tested by immunoblotting with specific antibodies. These facts, as well as the presence of multiple consensus sites for casein kinase II (CKII) phosphorylation, prompted us to test the involvement of this kinase in PA covalent modification. PA protein purified by immunoprecipitation could be specifically labelled by the catalytic alpha subunit of human CKII, which was expressed and purified from bacteria. Collectively, these data demonstrate that the PA subunit of the influenza virus RNA polymerase is a phosphoprotein.

  2. 8. LOWER STATION, FIRST FLOOR, EAST SIDE ACCESS TO INCLINE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. LOWER STATION, FIRST FLOOR, EAST SIDE ACCESS TO INCLINE PLANE CARS, LOOKING NORTH NORTHEAST. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  3. PREFACE: SPECIAL ISSUE OF ATMOSPHERIC ENVIRONMENT, FOR PARTICULATE MATTER: ATMOSPHERIC SCIENCES, EXPOSURE AND THE FOURTH COLLOQUIUM ON PM AND HUMAN HEALTH

    EPA Science Inventory

    In a continuing effort to improve communications among the atmospheric sciences, policy, and health communities, an international specialty conference was initiated in 2001 that took place in April 2003 in Pittsburgh, PA. The conference entitled, "Particulate Matter: Atmospheric...

  4. The Strategy of Elaborating a Common Approach to Solve the Problems of Surface and Ground Waters Contamination at the PA "Mayak" Territory Based on the International Co-operation Experience

    NASA Astrophysics Data System (ADS)

    Glinsky, M.; Hutter, A.; Drozhko, E. G.

    2001-12-01

    In the early 90's international organizations showed great interest concerning the contamination problems at the PA "Mayak" territory, where liquid radioactive wastes have been stored on the surface, including Lake Karachay, reservoir "Staroye Boloto" and the Techa River cascade reservoirs. As a result of this interest, international contracts funded by DOE (USA), NRRA, EC and DGXL were instituted to study the experience of radioactive waste management accumulated at the PA "Mayak" territory, including proposed rehabilitation of the contaminated territories. However, at the initial stage of international research, the works were not coordinated and often duplicated each other, which was taken by the public and mass media as a serious divergence of opinion between the scientists on the risk assessment for the population. Many years of research resulted in elaboration of a common scientific approach to the solution of the problems of water resources contamination at the PA "Mayak" territory. A successful experience of coordinating the international projects to study radionuclide migration with surface and ground waters at the PA "Mayak" territory is demonstrated, as well as the risk assessment for the population. Substantiation for rehabilitation measures can be based on long-term predictions and modeling research that are continuing under these international projects.

  5. Art, Science & Visual Literacy: Selected Readings from the Annual Conference of the International Visual Literacy Association (24th, Pittsburgh, Pennsylvania, September 30-October 4, 1992).

    ERIC Educational Resources Information Center

    Braden, Roberts A., Ed.; And Others

    Following an introductory paper on Pittsburgh and the arts, 57 conference papers are presented under the following four major categories: (1) "Imagery, Science and the Arts," including discovery in art and science, technology and art, visual design of newspapers, multimedia science education, science learning and interactive videodisc technology,…

  6. National Ovarian Cancer Coalition

    MedlinePlus

    ... 2018 National Conference April 27-29, 2018 in New York City, New York > Learn More Find Your Local Chapter Austin, TX ... Island, NY Massachusetts Nebraska New Hampshire New Jersey New York City, NY Pittsburgh, PA Sacramento, CA San Antonio, ...

  7. 45. AUXILIARY CHAMBER BETWEEN CHAMBER AND CONCRETE ENCLOSURE (LOCATION DDD), ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    45. AUXILIARY CHAMBER BETWEEN CHAMBER AND CONCRETE ENCLOSURE (LOCATION DDD), VIEW LOOKING EAST. LEAD ENCLOSED PIPING IS DRAIN FROM BOILER CHAMBER No. 1 - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  8. 96. SEED 1 FUEL ASSEMBLY FROM LOCATION L9 BEING REMOVED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    96. SEED 1 FUEL ASSEMBLY FROM LOCATION L-9 BEING REMOVED FROM REACTOR VESSEL BY MEANS OF FUEL EXTRACTION CRANE, JANUARY 7, 1960 - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  9. 8. VIEW FROM NORTHWEST OF CONDENSATE STORAGE TANK (LEFT), PRIMARY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. VIEW FROM NORTHWEST OF CONDENSATE STORAGE TANK (LEFT), PRIMARY WATER STORAGE TANK (CENTER), CANAL WATER STORAGE TANK (RIGHT) (LOCATIONS E,F,D) - Shippingport Atomic Power Station, On Ohio River, 25 miles Northwest of Pittsburgh, Shippingport, Beaver County, PA

  10. Second Generation Product Line Engineering Takes Hold in the DoD

    DTIC Science & Technology

    2014-01-01

    Feature- Oriented Domain Analysis ( FODA ) Feasibility Study” (CMU/SEI-90- TR-021, ADA235785). Pittsburgh, PA: Software Engineering Institute...software product line engineering and software architecture documentation and analysis . Clements is co-author of three practitioner-oriented books about

  11. 14. INTERIOR OF MAIN DECKNOTE LEVERS FROM CEILING CONTROLLED BY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. INTERIOR OF MAIN DECK--NOTE LEVERS FROM CEILING CONTROLLED BY OPERATOR. LEFT HAND LEVER CONTROLLED THROTTLE, RIGHT HAND LEVER CONTROLLED SHOT GUN SWINGER. - Dredge CINCINNATI, Docked on Ohio River at foot of Lighthill Street, Pittsburgh, Allegheny County, PA

  12. The Effects of Repeated Low-Dose Sarin Exposure

    DTIC Science & Technology

    2006-01-01

    Scientific (Pittsburgh, PA). Neostig- negative for the presence of agitation, chewing, tremors, facial dysmorphia , and mine bromide, acetylcholine chloride...no Chewing -- yes -no Facial Dysmorphia .--. yes -no Tremors ._...yes -no Vocalizations ... yes -no Animal handling Ease of removal from cage: (R

  13. 30. VIEW OF THE WESTERN SIDEWALK ON PIER 5, SHOWING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. VIEW OF THE WESTERN SIDEWALK ON PIER 5, SHOWING DEDICATION PLAQUE ON EASTERN PIER TOWER, LOOKING EAST - West End-North Side Bridge, Spanning Ohio River, approximately 1 mile downstream from confluence of Monongahela & Allegheny rivers, Pittsburgh, Allegheny County, PA

  14. Detection of Sources of Harmful Radiation using Portable Sensors

    DTIC Science & Technology

    2016-05-01

    Department Carnegie Mellon University Pittsburgh, PA Thesis Committee Artur Dubrawski, Chair Srinivas Narasimhan Submitted in partial fulfillment of the...Aggregation of Evidence for Detection and Characterization of Patterns in Multiple Noisy Observations”. PhD thesis. Carnegie Mellon, 2015. [15] Prateek Tandon

  15. Inside the covered hopper car loading dock at railroad level, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Inside the covered hopper car loading dock at railroad level, looking east from the 1945 elevator into the 1913 elevator, control for the railroad car puller in background - Stewart Company Grain Elevator, 16 West Carson Street, Pittsburgh, Allegheny County, PA

  16. 40 CFR 52.2027 - Approval status of Pennsylvania's Generic NOX and VOC RACT Rules.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... through 129.95 (see § 52.2020 (c)(129)) as those regulations apply to the Pittsburgh-Beaver Valley area... its approval of 25 PA Code of Regulations, Chapter 129.91 through 129.95 [see § 52.2020 (c)(129)] as...

  17. 40 CFR 52.2027 - Approval status of Pennsylvania's Generic NOX and VOC RACT Rules.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... through 129.95 (see § 52.2020 (c)(129)) as those regulations apply to the Pittsburgh-Beaver Valley area... its approval of 25 PA Code of Regulations, Chapter 129.91 through 129.95 [see § 52.2020 (c)(129)] as...

  18. 13. LOWER STATION, SECOND FLOOR, BOARD OF DIRECTORS' MEETING ROOM, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. LOWER STATION, SECOND FLOOR, BOARD OF DIRECTORS' MEETING ROOM, SOUTHWEST WALL, MONONGAHELA INCLINE PLANE COMPANY SAFE. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  19. 24. UPPER STATION, LOWER FLOOR, MOTOR ROOM, OFF VERTICAL DEFLECTOR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. UPPER STATION, LOWER FLOOR, MOTOR ROOM, OFF VERTICAL DEFLECTOR SHEAVE, MOTOR, BRAKE, PINION SHAFT, DRIVE WHEEL. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  20. 9. LOWER STATION, FIRST FLOOR, DOORS FOR EAST SIDE ACCESS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. LOWER STATION, FIRST FLOOR, DOORS FOR EAST SIDE ACCESS TO INCLINE PLANE CARS, LOOKING EAST SOUTHEAST. - Monongahela Incline Plane, Connecting North side of Grandview Avenue at Wyoming Street with West Carson Street near Smithfield Street, Pittsburgh, Allegheny County, PA

  1. 76 FR 59160 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Robotics...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-23

    ... Production Act of 1993--Robotics Technology Consortium, Inc. Notice is hereby given that, on July 27, 2011... seq. (``the Act''), the Robotics Technology Consortium (``RTC'') has filed written notifications... Machining, Longmont, CA; Carnegie Robotics LLC, Pittsburgh, PA; Embry-Riddle Aeronautical University...

  2. 4. VIEW LOOKING WEST FROM BASEMENT UNDER OPEN CONCOURSE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. VIEW LOOKING WEST FROM BASEMENT UNDER OPEN CONCOURSE - CEILING OF BRICK ARCHES; WOOD PANELS MARK LOCATION OF ORIGINAL GLASS PRISM SKYLIGHTS REPLACED WITH CONCRETE - Pennsylvania Railroad Station, Open Concourse & Concourse Roof Extension, 1101 Liberty Avenue, Pittsburgh, Allegheny County, PA

  3. GENERAL VIEW OF WESTERN PART OF PLANT INCLUDING (LEFT TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    GENERAL VIEW OF WESTERN PART OF PLANT INCLUDING (LEFT TO RIGHT) BETHLEHEM RAIL MILL, GENERAL OFFICE BUILDING, MACHINE SHOP, BAR MILL, BLOOMING MILL & OPEN HEARTH PLANT. - Pittsburgh Steel Company, Monessen Works, Open Hearth Plant, Donner Avenue, Monessen, Westmoreland County, PA

  4. 4th level of 1913 elevator indicating sacking scale, part of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4th level of 1913 elevator indicating sacking scale, part of the bagging system and nate to the sewing machine. Discharge spout for the grain bin to the left - Stewart Company Grain Elevator, 16 West Carson Street, Pittsburgh, Allegheny County, PA

  5. 1. GENERAL OFFICE BUILDING FOR THE HOMESTEAD WORKS, DESIGNED BY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. GENERAL OFFICE BUILDING FOR THE HOMESTEAD WORKS, DESIGNED BY HOFFMAN & CRUMPTON OF PITTSBURGH. THE BUILDING WAS DESIGNED TO SHOWCASE THE ARCHITECTURAL POSSIBILITIES OF STEEL. - U.S. Steel Homestead Works, Auxiliary Buildings & Shops, Along Monongahela River, Homestead, Allegheny County, PA

  6. Education for Highway Engineering and Highway Transport. Report of the Regional Conference Held at University of Pittsburgh, Friday, November 26, 1920. Bulletin, 1921, No. 47

    ERIC Educational Resources Information Center

    Johnson, Pyke; John, Walton C.

    1921-01-01

    This bulletin provides information on the proceedings of the regional conference on education for highway engineering and highway transport that was held at the University of Pittsburgh on November 26, 1920, under the direction of the highway and highway transport education committee. The purpose of this report is: (1) To stimulate greater…

  7. Laterally Vibrating Resonator Based Elasto-Optic Modulation in Aluminum Nitride

    DTIC Science & Technology

    2016-08-15

    Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA (Received 1 February 2016; accepted...to acknowledge process related support from the staff at the Carnegie Mellon Nanofabrication Facility as well as funding support from the National

  8. 33 CFR 110.67 - Delaware River, Essington, Pa.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Delaware River, Essington, Pa. 110.67 Section 110.67 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.67 Delaware River, Essington, Pa. North of...

  9. 33 CFR 110.67 - Delaware River, Essington, Pa.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Delaware River, Essington, Pa. 110.67 Section 110.67 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.67 Delaware River, Essington, Pa. North of...

  10. 33 CFR 110.67 - Delaware River, Essington, Pa.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Delaware River, Essington, Pa. 110.67 Section 110.67 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.67 Delaware River, Essington, Pa. North of...

  11. 33 CFR 110.67 - Delaware River, Essington, Pa.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Delaware River, Essington, Pa. 110.67 Section 110.67 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.67 Delaware River, Essington, Pa. North of...

  12. 33 CFR 110.67 - Delaware River, Essington, Pa.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Delaware River, Essington, Pa. 110.67 Section 110.67 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.67 Delaware River, Essington, Pa. North of...

  13. Genomic and transcriptomic differences in community acquired methicillin resistant Staphylococcus aureus USA300 and USA400 strains.

    PubMed

    Jones, Marcus B; Montgomery, Christopher P; Boyle-Vavra, Susan; Shatzkes, Kenneth; Maybank, Rosslyn; Frank, Bryan C; Peterson, Scott N; Daum, Robert S

    2014-12-19

    Staphylococcus aureus is a human pathogen responsible for substantial morbidity and mortality through its ability to cause a number of human infections including bacteremia, pneumonia and soft tissue infections. Of great concern is the emergence and dissemination of methicillin-resistant Staphylococcus aureus strains (MRSA) that are resistant to nearly all β-lactams. The emergence of the USA300 MRSA genetic background among community associated S. aureus infections (CA-MRSA) in the USA was followed by the disappearance of USA400 CA-MRSA isolates. To gain a greater understanding of the potential fitness advantages and virulence capacity of S. aureus USA300 clones, we performed whole genome sequencing of 15 USA300 and 4 USA400 clinical isolates. A comparison of representative genomes of the USA300 and USA400 pulsotypes indicates a number of differences in mobile genome elements. We examined the in vitro gene expression profiles by microarray hybridization and the in vivo transcriptomes during lung infection in mice of a USA300 and a USA400 MRSA strain by performing complete genome qRT-PCR analysis. The unique presence and increased expression of 6 exotoxins in USA300 (12- to 600-fold) compared to USA400 may contribute to the increased virulence of USA300 clones. Importantly, we also observed the up-regulation of prophage genes in USA300 (compared with USA400) during mouse lung infection (including genes encoded by both prophages ΦSa2usa and ΦSa3usa), suggesting that these prophages may play an important role in vivo by contributing to the elevated virulence characteristic of the USA300 clone. We observed differences in the genetic content of USA300 and USA400 strains, as well as significant differences of in vitro and in vivo gene expression of mobile elements in a lung pneumonia model. This is the first study to document the global transcription differences between USA300 and USA400 strains during both in vitro and in vivo growth.

  14. Apparatus to measure the vapor pressure of slowly decomposing compounds from 1 Pa to 105 Pa

    PubMed Central

    Berg, Robert F.

    2016-01-01

    This article describes an apparatus and method for measuring vapor pressures in the range from 1 Pa to 105 Pa. Its three distinctive elements are : (1) the static pressure measurements were made with only a small temperature difference between the vapor and the condensed phase, (2) the sample was degassed in situ, and (3) the temperature range extended up to 200 °C. The apparatus was designed to measure metal-organic precursors, which often are toxic, pyrophoric, or unstable. Vapor pressures are presented for naphthalene, ferrocene, diethyl phthalate, and TEMAH (tetrakisethylmethylaminohafnium). Also presented are data for the temperature-dependent decomposition rate of TEMAH. PMID:27274567

  15. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 5 2014-07-01 2014-07-01 false PA self assessments/inspections. 701.124 Section 701.124 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.124 PA self assessments...

  16. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false PA self assessments/inspections. 701.124 Section 701.124 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.124 PA self assessments...

  17. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false PA self assessments/inspections. 701.124 Section 701.124 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.124 PA self assessments...

  18. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 5 2013-07-01 2013-07-01 false PA self assessments/inspections. 701.124 Section 701.124 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.124 PA self assessments...

  19. 32 CFR 701.124 - PA self assessments/inspections.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false PA self assessments/inspections. 701.124 Section 701.124 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.124 PA self assessments...

  20. What they say and what they do: comparing physical activity across the USA, England and the Netherlands.

    PubMed

    Kapteyn, Arie; Banks, James; Hamer, Mark; Smith, James P; Steptoe, Andrew; van Soest, Arthur; Koster, Annemarie; Htay Wah, Saw

    2018-06-01

    Physical activity (PA) is important for maintaining health, but there are fundamental unanswered questions on how best it should be measured. We measured PA in the Netherlands (n=748), the USA (n=540) and England (n=254), both by a 7 day wrist-worn accelerometer and by self-reports. The self-reports included a global self-report on PA and a report on the frequency of vigorous, moderate and mild activity. The self-reported data showed only minor differences across countries and across groups within countries (such as different age groups or working vs non-working respondents). The accelerometer data, however, showed large differences; the Dutch and English appeared to be much more physically active than Americans h (For instance, among respondents aged 50 years or older 38% of Americans are in the lowest activity quintile of the Dutch distribution). In addition, accelerometer data showed a sharp decline of PA with age, while no such pattern was observed in self-reports. The differences between objective measures and self-reports occurred for both types of self-reports. It is clear that self-reports and objective measures tell vastly different stories, suggesting that across countries people use different response scales when answering questions about how physically active they are. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  1. Technical Insights for Saltstone PA Maintenance

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Flach, G.; Sarkar, S.; Mahadevan, S.

    2011-07-20

    The Cementitious Barriers Partnership (CBP) is a collaborative program sponsored by the US DOE Office of Waste Processing. The objective of the CBP is to develop a set of computational tools to improve understanding and prediction of the long-term structural, hydraulic, and chemical performance of cementitious barriers and waste forms used in nuclear applications. CBP tools are expected to better characterize and reduce the uncertainties of current methodologies for assessing cementitious barrier performance and increase the consistency and transparency of the assessment process, as the five-year program progresses. In September 2009, entering its second year of funded effort, the CBPmore » sought opportunities to provide near-term tangible support to DOE Performance Assessments (PAs). The Savannah River Saltstone Disposal Facility (SDF) was selected for the initial PA support effort because (1) cementitious waste forms and barriers play a prominent role in the performance of the facility, (2) certain important long-term behaviors of cementitious materials composing the facility are uncertain, (3) review of the SDF PA by external stakeholders is ongoing, and (4) the DOE contractor responsible for the SDF PA is open to receiving technical assistance from the CBP. A review of the current (SRR Closure & Waste Disposal Authority 2009) and prior Saltstone PAs (e.g., Cook et al. 2005) suggested five potential opportunities for improving predictions. The candidate topics considered were (1) concrete degradation from external sulfate attack, (2) impact of atmospheric exposure to concrete and grout before closure, such as accelerated slag and Tc-99 oxidation, (3) mechanistic prediction of geochemical conditions, (4) concrete degradation from rebar corrosion due to carbonation, and (5) early age cracking from drying and/or thermal shrinkage. The candidate topics were down-selected considering the feasibility of addressing each issue within approximately six months, and

  2. Looking southwest at the chute leading from the coal elevator ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking southwest at the chute leading from the coal elevator to the conveyor belt feeding the coal storage hopper on the floor below. - Wheeling-Pittsburgh Steel Corporation, Allenport Works, Boiler House, Route 88 on West bank of Monongahela River, Allenport, Washington County, PA

  3. 78 FR 58994 - National Urban and Community Forestry Advisory Council Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-25

    ... Forestry Advisory Council will meet on November 5 and 6, 2013. The meeting will be held in Pittsburgh, PA... November 5 and 6, 2013, from 1:00 p.m. to 5:00 p.m. each day or until Council business is completed...

  4. Memristive Materials and Devices

    DTIC Science & Technology

    2013-11-19

    public release. AIR FORCE RESEARCH LABORATORY AF OFFICE OF SCIENTIFIC RESEARCH (AFOSR)/ RSE ARLINGTON, VIRGINIA 22203 AIR FORCE MATERIEL COMMAND AFRL...Avenue, Pittsburgh, PA 15213 Dr. Gernot Pomrenke AFOSR/ RSE 875 North Randolph Street Arlington, VA 22203 CMU proved that the filaments in

  5. 9. Photocopy of original construction drawing, dated February 1932 (original ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Photocopy of original construction drawing, dated February 1932 (original print in possession of Veterans Administration, Oakland Branch, Pittsburgh, Pennsylvania). DRAWING 103-26 -- PLOT PLAN -- SHOWING NEW CONSTRUCTION - VA Medical Center, Aspinwall Division, 5103 Delafield Avenue (O'Hara Township), Aspinwall, Allegheny County, PA

  6. Information Processing Research

    DTIC Science & Technology

    1979-06-01

    quantitative shape recovery. For the qualitative shape recovery we use a model of the Origami world (Kanade, 1978), together with edge profiles of...Workshop. Carnegie-Mellon University, Computer Science Department, Pittsburgh, PA, November, 1978. Kanade, T. A theory of origami world. Technical

  7. VIEW OF SEMIDISMANTLED HOPPER CAR ON THE ORE TRESTLE FACING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF SEMI-DISMANTLED HOPPER CAR ON THE ORE TRESTLE FACING NORTHWEST WITH OPEN HEARTH BUILDING IN THE BACKGROUND AND THE INGOT MOLD CONDITIONING BUILDING TO THE RIGHT. - Pittsburgh Steel Company, Monessen Works, Open Hearth Plant, Donner Avenue, Monessen, Westmoreland County, PA

  8. 76 FR 57037 - Notice to All Interested Parties of the Termination of the Receivership of 10000, Metropolitan...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... Receivership of 10000, Metropolitan Savings Bank, Pittsburgh, PA Notice is Hereby Given that the Federal Deposit Insurance Corporation (``FDIC'') as Receiver for Metropolitan Savings Bank, (``the Receiver... Metropolitan Savings Bank on February 2, 2007. The liquidation of the receivership assets has been completed...

  9. 10 CFR 600.10 - Form and content of applications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Energy Technology Center, Attn: Unsolicited Proposal Manager, Post Office Box 10940, Pittsburgh, PA...: (1) A facesheet containing basic identifying information. The facesheet shall be the Standard Form... electronically, by an official authorized to bind the applicant; or (2) Omits any information or documentation...

  10. 7. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. Sec. 1101, MP 3.11. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  11. 6. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. B & O RAILROAD BRIDGE. PHILADELPHIA, PHILADELPHIA CO., PA. Sec. 1101, MP 3.11. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  12. 32 CFR 701.109 - Privacy Act (PA) appeals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false Privacy Act (PA) appeals. 701.109 Section 701.109 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.109 Privacy Act (PA) appeals. (a...

  13. 32 CFR 701.109 - Privacy Act (PA) appeals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false Privacy Act (PA) appeals. 701.109 Section 701.109 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.109 Privacy Act (PA) appeals. (a...

  14. 32 CFR 701.109 - Privacy Act (PA) appeals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 5 2013-07-01 2013-07-01 false Privacy Act (PA) appeals. 701.109 Section 701.109 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.109 Privacy Act (PA) appeals. (a...

  15. 32 CFR 701.109 - Privacy Act (PA) appeals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 5 2014-07-01 2014-07-01 false Privacy Act (PA) appeals. 701.109 Section 701.109 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.109 Privacy Act (PA) appeals. (a...

  16. 32 CFR 701.109 - Privacy Act (PA) appeals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Privacy Act (PA) appeals. 701.109 Section 701.109 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY UNITED STATES NAVY... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.109 Privacy Act (PA) appeals. (a...

  17. 78 FR 26243 - Amendment of Class E Airspace; Easton, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ...-0394; Airspace Docket No. 12-AEA-8] Amendment of Class E Airspace; Easton, PA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class E Airspace at Easton, PA, as the... (NPRM) to amend Class E airspace at Easton, PA (78 FR 5152) Docket No. FAA-2012-0394. Interested parties...

  18. Industrial Hygiene Air Sampling and Bulk Sampling Instructions

    DTIC Science & Technology

    1990-12-01

    registered trademark of Johns - Manville Products Corp., Denver, CO. "Cellosolve is a registered trademark of Union Carbide Corp., 270 Park Ave, New...registered trademark of Johns - Manville Products Corp., Denver, CO. 0 &Florisil is a registered trademark of Floridin Company, ITT System, Pittsburgh, PA. C...Thermosorb is a registered trademark of Johns - Manville Products Corp., Denver, CO. ®XAD-2 is a registered trademark of Rohm and Haas, Philadelphia, PA. C

  19. Tobago Prostate Survey: Prostate Cancer Risk in a Large Population-Based Study of Men of African Descent

    DTIC Science & Technology

    2001-06-01

    Pittsburgh Central Pathology Laboratory using the automated Microparticle Enzyme Immunoassay, Abbot AxSYM PSA assay (Abbott Laboratories, Abbott Park, IL, USA...1997) pesticide applicators in Sweden (Dich & Wik/und, 1998) "* No evidence of an association (Giovannuccietal., 1997; * Increased risk for soap

  20. Celastrol reverses palmitic acid (PA)-caused TLR4-MD2 activation-dependent insulin resistance via disrupting MD2-related cellular binding to PA.

    PubMed

    Zhang, Xue; Wang, Ying; Ge, Hui-Ya; Gu, Yi-Jun; Cao, Fan-Fan; Yang, Chun-Xin; Uzan, Georges; Peng, Bin; Zhang, Deng-Hai

    2018-04-18

    Elevated plasma statured fatty acids (FFAs) cause TLR4/MD2 activation-dependent inflammation and insulin tolerance, which account for the occurrence and development of obesity. It has been confirmed that statured palmitic acid (PA) (the most abundant FFA) could bind MD2 to cause cellular inflammation. The natural compound celastrol could improve obesity, which is suggested via inhibiting inflammation, yet the detailed mechanism for celastrol is still unclear. As celastrol is reported to directly target MD2, we thought disrupting the binding between FFAs and MD2 might be one of the ways for celastrol to inhibit FFAs-caused inflammation and insulin resistance. In this study, we found evidence to support our hypothesis: celastrol could reverse PA-caused TLR4/MD2 activation-dependent insulin resistance, as determined by glucose-lowering ability, cellular glucose uptake, insulin action-related proteins and TLR4/MD2/NF-κB activation. Bioinformatics and cellular experiments showed that both celastrol and PA could bind MD2, and that celastrol could expel PA from cells. Finally, celastrol could reverse high fat diet caused hyperglycemia and obesity, and liver NF-kB activations. Taking together, we proved that celastrol could reverses PA-caused TLR4-MD2 activation-dependent insulin resistance via disrupting PA binding to MD2. © 2018 Wiley Periodicals, Inc.

  1. Ammonia Sensing Behaviors of TiO2-PANI/PA6 Composite Nanofibers

    PubMed Central

    Wang, Qingqing; Dong, Xianjun; Pang, Zengyuan; Du, Yuanzhi; Xia, Xin; Wei, Qufu; Huang, Fenglin

    2012-01-01

    Titanium dioxide-polyaniline/polyamide 6 (TiO2-PANI/PA6) composite nanofibers were prepared by in situ polymerization of aniline in the presence of PA6 nanofibers and a sputtering-deposition process with a high purity titanium sputtering target. TiO2-PANI/PA6 composite nanofibers and PANI/PA6 composite nanofibers were fabricated for ammonia gas sensing. The ammonia sensing behaviors of the sensors were examined at room temperature. All the results indicated that the ammonia sensing property of TiO2-PANI/PA6 composite nanofibers was superior to that of PANI/PA6 composite nanofibers. TiO2-PANI/PA6 composite nanofibers had good selectivity to ammonia. It was also found that the content of TiO2 had a great influence on both the morphology and the sensing property of TiO2-PANI/PA6 composite nanofibers. PMID:23235446

  2. Longitudinal relationship between physical activity and cardiometabolic factors in overweight and obese adults

    PubMed Central

    Choo, Jina; Elci, Okan U.; Yang, Kyeongra; Turk, Melanie W.; Styn, Mindi A.; Sereika, Susan M.; Music, Edvin; Burke, Lora E.

    2012-01-01

    Few studies have reported longitudinal relationships between physical activity (PA) and cardiometabolic risk factors over time using repeated assessments in overweight or obese adults. We conducted a longitudinal study in 127 participants (81% with body mass index > 30 kg/m2) who completed a 12-month behavioral intervention for weight loss between 2003 and 2005 in Pittsburgh, PA, USA. Using absolute change scores from baseline to each time point (i.e., 6 and 12 months) for all studied variables (Δ = time point – baseline), we performed mixed effects modeling to examine relationships between PA and cardiometabolic risk factors, after adjusting for body weight, energy intake and other covariates (i.e., age, gender, and ethnicity). PA was assessed as energy expenditure (kcal/week) using the Paffenbarger activity questionnaire. Over the 12-month period, energy expenditure increased (Δ1,370 kcal/week at 6 months vs. Δ886 kcal/week at 12 months); body weight decreased (Δ8.9 kg at 6 months vs. Δ8.4 kg at 12 months). The average increase in energy expenditure over 12 months was significantly and independently related to reductions in total cholesterol (F = 6.25, p = 0.013), low-density lipoprotein cholesterol (LDL-C) (F = 5.08, p = 0.025) and fasting blood glucose (F = 5.10, p = 0.025), but not to other risk factors (i.e., fasting insulin, high-density lipoprotein cholesterol, triglycerides, and waist circumference). In conclusion, among overweight and obese adults undergoing a weight loss intervention, increased energy expenditure over 12 months may improve total cholesterol and LDL-C, important coronary risk factors, and fasting blood glucose, a metabolic risk factor. PMID:19806358

  3. Development of a new dynamic gas flow-control system in the pressure range of 1 Pa-133 Pa

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hong, S. S.; Chung, J. W.; Khan, Wakil

    2011-12-15

    A new flow-control system (FCS-705) has been developed at Korea Research Institute of Standards and Science. The system is intended for calibration of vacuum gauges in the pressure range of 1 Pa-133 Pa by comparison method. This paper describes some basic characteristics of the system including; (1) the design and construction of the system, (2) the generation of stable pressures in the chamber, (3) achieving high upstream pressure limit by installing a short duct in the by-pass pumping line, and (4) investigation of the gas flow regimes within the short duct.

  4. 77 FR 27863 - Privacy Act of 1974; System of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-11

    ... Therapy (CWT), HUD/VA Prevention pilot, and Supportive Services for Veterans and Families (SSVF). This... Veterans and their immediate family members, members of the armed services, current and former employees... Location Addiction Severity Index Veteran Affairs Medical Center, 7180 Highland Drive, Pittsburgh, PA 15206...

  5. 31. Photocopy of map. Insert from Master Plan Notes Prepared ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    31. Photocopy of map. Insert from Master Plan Notes Prepared by Environmental Planning and Design, Pittsburgh, Pa. Original at Missouri Botanical Garden. 1972 MASTER PLAN 32. 'THE TREE,' SCULPTURE BY ALEXANDER CALDER, 1966 - Missouri Botanical Garden, 2345 Tower Grove Avenue, Saint Louis, Independent City, MO

  6. An Archeological Overview and Management Plan for the Hays Army Ammunition Plant, Allegheny County, Pennsylvania.

    DTIC Science & Technology

    1984-05-07

    farming in the Pittsburgh area. Nineteenth century settlers -:e of mostly Celtic and German heritage (Klein and Hoogenboom 1980:44-45), and eventually...Harrisburg, PA: The Pennsylvania Historical and Museum Comission. Klein, Philip S., and ri Hoogenboom . 1980. A History of Pennsylvania. 2nd ed

  7. General view, looking SE during repainting, restoration, and rebuilding of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    General view, looking SE during repainting, restoration, and rebuilding of roadway and bridge truss system. Scaffolding designed to minimize environmental damage from paint chips, paint vapors, and dirt. - Schenley Park Bridge over Panther Hollow, Spanning Panther Hollow at Panther Hollow Road, Pittsburgh, Allegheny County, PA

  8. Nutrition Education--1973. Part 7--School Nutrition Education Programs. Hearings Held Pittsburgh, Pa., May 25, 1973. Hearings Before the Select Committee on Nutrition and Human Needs of the United States Senate, Ninety-third Congress, First Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Select Committee on Nutrition and Human Needs.

    The following witnesses testified before these hearings of the Select Committee on Nutrition and Human Needs: Mrs. G. Marsh, area consultant, Division of Food and Nutrition Services, Pennsylvania Department of Education; Mrs. G. Chegwidden, director, School Food Service, Franklin Regional School District, Murrysville, Pa.; Mr. S. Lympany, senior…

  9. Notification: Northwest Indian Fisheries Commission’s Puget Sound Protection and Restoration Implementation cooperative agreements PA00J32201 and PA00J91201

    EPA Pesticide Factsheets

    May 27, 2016. The EPA OIG plans to begin preliminary research on the Northwest Indian Fisheries Commission’s (NWIFC’s) Puget Sound Protection and Restoration Implementation cooperative agreements PA00J32201 and PA00J91201.

  10. 75 FR 38146 - Pittsburgh Coatings, Inc., Ambridge, PA; Notice of Revised Determination on Reconsideration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-01

    ... Notice of negative determination regarding workers' eligibility to apply for Trade Adjustment Assistance... employment related to the production of painted and coated structural steel. The negative determination was... date of this certification, and all workers in the group threatened with total or partial separation...

  11. Concussion is Treatable: Statements of Agreement from the Targeted Evaluation and Active Management (TEAM) Approaches to Treating Concussion Meeting held in Pittsburgh, October 15–16, 2015

    PubMed Central

    Collins, Michael W.; Kontos, Anthony P.; Okonkwo, David O.; Almquist, Jon; Bailes, Julian; Barisa, Mark; Bazarian, Jeffrey; Bloom, O. Josh; Brody, David; Cantu, Robert; Cardenas, Javier; Clugston, Jay; Cohen, Randall; Echemendia, Ruben; Elbin, R.J.; Ellenbogen, Richard; Fonseca, Janna; Gioia, Gerard; Guskiewicz, Kevin; Heyer, Robert; Hotz, Gillian; Iverson, Grant L.; Jordan, Barry; Manley, Geoffrey; Maroon, Joseph; McAllister, Thomas; McCrea, Michael; Mucha, Anne; Pieroth, Elizabeth; Podell, Kenneth; Pombo, Matthew; Shetty, Teena; Sills, Allen; Solomon, Gary; Thomas, Danny G.; Valovich McLeod, Tamara C.; Yates, Tony; Zafonte, Ross

    2016-01-01

    Background Conventional management for concussion involves prescribed rest and progressive return to activity. Recent evidence challenges this notion and suggests that active approaches may be effective for some patients. Previous concussion consensus statements provide limited guidance regarding active treatment. Objective To describe the current landscape of treatment for concussion and provide summary agreements related to treatment in order to assist clinicians in the treatment of concussion. Methods On October 14–16, 2015, the Targeted Evaluation & Active Management (TEAM) Approaches To Treating Concussion meeting was convened in Pittsburgh, Pennsylvania, USA. 37 concussion experts from neuropsychology, neurology, neurosurgery, sports medicine, physical medicine and rehabilitation, physical therapy, athletic training, and research, and 12 individuals representing sport, military, and public health organizations attended the meeting. The 37 experts indicated their agreement on a series of statements using an audience response system clicker device. Results A total of 16 statements of agreement were supported covering: 1) Summary of the Current Approach to Treating Concussion, 2) Heterogeneity and Evolving Clinical Profiles of Concussion, 3) Targeted Evaluation and Active Management Approach to Concussion Treatment: Specific Strategies, and 4) Future Directions: A Call to Research. Support (ie, response of agree or somewhat agree) for the statements ranged from to 97–100%. Conclusion Concussions are characterized by diverse symptoms and impairments and evolving clinical profiles; recovery varies based on modifying factors, injury severity, and treatments. Active and targeted treatments may enhance recovery following concussion. Research is needed on concussion clinical profiles, biomarkers, and the effectiveness and timing of treatments. PMID:27741219

  12. 78 FR 5129 - Amendment of Class E Airspace; Wilkes-Barre, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-24

    ... Wilkes-Barre, PA, creating controlled airspace to accommodate new area navigation (RNAV) Standard... Wilkes-Barre, PA, area by creating controlled airspace at Wilkes-Barre/ Wyoming Valley Airport, Wilkes... in the Wilkes-Barre, PA, area by creating controlled airspace extending upward form 700 feet above...

  13. 75 FR 50774 - Towing Safety Advisory Committee; Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-17

    ... will meet in Pittsburgh, PA. The Committee will also discuss various issues relating to shallow-draft... Secretary of the Department of Homeland Security (DHS) on matters relating to shallow-draft inland and... reflecting the Committee's independent judgment to the Secretary on matters and actions concerning shallow...

  14. Publications and Presentations of the Opthalmology Branch, USAF School of Aerospace Medicine 1981-1990

    DTIC Science & Technology

    1990-12-01

    Meeting CORNEAL OPACIFICATION AND LECITHIN -CHOLESTEROL ACETYLTRANSFERASE (LCAT) DEFICIENCY: A CASE REPORT Hesterberg RC Jr and TJ Tredici Annals of...Pittsburgh PA, 14 May 1987 OCULAR SIDE EFFECTS OF HYPERBARIC OXYGEN THERAPY Tredici TJ, LL Tredici, DJ Ivan, and PS O’Connor Baylor College of Medicine

  15. 77 FR 60339 - Approval and Promulgation of Air Quality Implementation Plans; Pennsylvania; The 2002 Base Year...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-03

    ... Promulgation of Air Quality Implementation Plans; Pennsylvania; The 2002 Base Year Inventory for the Pittsburgh... particulate matter (PM 2.5 ) 2002 base year emissions inventory portion of the Pennsylvania State... Valley, PA nonattainment area (hereafter referred to as the Area). The emissions inventory is part of the...

  16. Turning Down the Noise in the Blogosphere

    DTIC Science & Technology

    2009-05-01

    Turning Down the Noise in the Blogosphere Khalid El-Arini, Gaurav Veda , Dafna Shahaf, Carlos Guestrin May 2009 CMU-ML-09-103 Report Documentation...Arini Gaurav Veda Dafna Shahaf Carlos Guestrin May 2009 CMU-ML-09-103 School of Computer Science Carnegie Mellon University Pittsburgh, PA 15213

  17. 75 FR 12718 - Hazard Communication; Meetings Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-17

    ... Communication; Meetings Notice AGENCY: Occupational Safety and Health Administration (OSHA), Department of Labor... Communication Standard in Washington, DC; Pittsburgh, PA; and Los Angeles, CA (74 FR 68756). OSHA will hold the... of Communications, Room N-3647, U.S. Department of Labor, 200 Constitution Avenue, NW., Washington...

  18. 1. EAST AND SOUTH SIDES OF STATION, SHOWING (LEFT BACKGROUND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. EAST AND SOUTH SIDES OF STATION, SHOWING (LEFT BACKGROUND TO CENTER FOREGROUND) SOUTH CANOPY, OPEN CONCOURSE ROOF, AND CONCOURSE ROOF EXTENSION (SMALL BUILDING UNDER CONCOURSE ROOF IS TEMPORARY AMTRAK STATION) - Pennsylvania Railroad Station, Open Concourse & Concourse Roof Extension, 1101 Liberty Avenue, Pittsburgh, Allegheny County, PA

  19. 13. Photocopy of original construction drawing, dated November 1932 (original ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Photocopy of original construction drawing, dated November 1932 (original print in possession of Veterans Administration, Oakland Branch, Pittsburgh, Pennsylvania). DRAWING 32-3 -- ADMINISTRATION BUILDING, BUILDING NO. 32 -- FIRST AND SECOND FLOOR PLANS. - VA Medical Center, Aspinwall Division, Administration Building, 5103 Delafield Avenue, Aspinwall, Allegheny County, PA

  20. 12. Photocopy of original construction drawing, dated November 1932 (original ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Photocopy of original construction drawing, dated November 1932 (original print in possession of Veterans Administration, Oakland Branch, Pittsburgh, Pennsylvania). DRAWING 32-2 -- ADMINISTRATION BUILDING, BUILDING NO. 32 -- BASEMENT PLAN AND CUPOLA DETAIL. - VA Medical Center, Aspinwall Division, Administration Building, 5103 Delafield Avenue, Aspinwall, Allegheny County, PA

  1. 4th level of 1945 warehouse indicating drag conveyor. From here ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4th level of 1945 warehouse indicating drag conveyor. From here screenings were pumped from the elevator leg to this conveyor. The grains were ground, then conveyed back down to the first floor for bagging. - Stewart Company Grain Elevator, 16 West Carson Street, Pittsburgh, Allegheny County, PA

  2. 22. VIEW LOOKING FROM FRONT LEFT OF DREDGE TOWARDS GEAR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. VIEW LOOKING FROM FRONT LEFT OF DREDGE TOWARDS GEAR DRIVE OF MAIN (HOISTING) ENGINE. ARM ON RIGHT IS PART OF VALVE LINKAGE. BOX ABOVE THAT IS THE CYLINDER OIL LUBRICATOR. - Dredge CINCINNATI, Docked on Ohio River at foot of Lighthill Street, Pittsburgh, Allegheny County, PA

  3. tPA Prescription and Administration Errors within a Regional Stroke System

    PubMed Central

    Chung, Lee S; Tkach, Aleksander; Lingenfelter, Erin M; Dehoney, Sarah; Rollo, Jeannie; de Havenon, Adam; DeWitt, Lucy Dana; Grantz, Matthew Ryan; Wang, Haimei; Wold, Jana J; Hannon, Peter M; Weathered, Natalie R; Majersik, Jennifer J

    2015-01-01

    Background IV tPA utilization in acute ischemic stroke (AIS) requires weight-based dosing and a standardized infusion rate. In our regional network, we have tried to minimize tPA dosing errors. We describe the frequency and types of tPA administration errors made in our comprehensive stroke center (CSC) and at community hospitals (CHs) prior to transfer. Methods Using our stroke quality database, we extracted clinical and pharmacy information on all patients who received IV tPA from 2010–11 at the CSC or CH prior to transfer. All records were analyzed for the presence of inclusion/exclusion criteria deviations or tPA errors in prescription, reconstitution, dispensing, or administration, and analyzed for association with outcomes. Results We identified 131 AIS cases treated with IV tPA: 51% female; mean age 68; 32% treated at CSC, 68% at CH (including 26% by telestroke) from 22 CHs. tPA prescription and administration errors were present in 64% of all patients (41% CSC, 75% CH, p<0.001), the most common being incorrect dosage for body weight (19% CSC, 55% CH, p<0.001). Of the 27 overdoses, there were 3 deaths due to systemic hemorrhage or ICH. Nonetheless, outcomes (parenchymal hematoma, mortality, mRS) did not differ between CSC and CH patients nor between those with and without errors. Conclusion Despite focus on minimization of tPA administration errors in AIS patients, such errors were very common in our regional stroke system. Although an association between tPA errors and stroke outcomes was not demonstrated, quality assurance mechanisms are still necessary to reduce potentially dangerous, avoidable errors. PMID:26698642

  4. Geostatistical modeling of the gas emission zone and its in-place gas content for Pittsburgh-seam mines using sequential Gaussian simulation

    USGS Publications Warehouse

    Karacan, C.O.; Olea, R.A.; Goodman, G.

    2012-01-01

    Determination of the size of the gas emission zone, the locations of gas sources within, and especially the amount of gas retained in those zones is one of the most important steps for designing a successful methane control strategy and an efficient ventilation system in longwall coal mining. The formation of the gas emission zone and the potential amount of gas-in-place (GIP) that might be available for migration into a mine are factors of local geology and rock properties that usually show spatial variability in continuity and may also show geometric anisotropy. Geostatistical methods are used here for modeling and prediction of gas amounts and for assessing their associated uncertainty in gas emission zones of longwall mines for methane control.This study used core data obtained from 276 vertical exploration boreholes drilled from the surface to the bottom of the Pittsburgh coal seam in a mining district in the Northern Appalachian basin. After identifying important coal and non-coal layers for the gas emission zone, univariate statistical and semivariogram analyses were conducted for data from different formations to define the distribution and continuity of various attributes. Sequential simulations performed stochastic assessment of these attributes, such as gas content, strata thickness, and strata displacement. These analyses were followed by calculations of gas-in-place and their uncertainties in the Pittsburgh seam caved zone and fractured zone of longwall mines in this mining district. Grid blanking was used to isolate the volume over the actual panels from the entire modeled district and to calculate gas amounts that were directly related to the emissions in longwall mines.Results indicated that gas-in-place in the Pittsburgh seam, in the caved zone and in the fractured zone, as well as displacements in major rock units, showed spatial correlations that could be modeled and estimated using geostatistical methods. This study showed that GIP volumes may

  5. Geostatistical modeling of the gas emission zone and its in-place gas content for Pittsburgh-seam mines using sequential Gaussian simulation

    PubMed Central

    Karacan, C. Özgen; Olea, Ricardo A.; Goodman, Gerrit

    2015-01-01

    Determination of the size of the gas emission zone, the locations of gas sources within, and especially the amount of gas retained in those zones is one of the most important steps for designing a successful methane control strategy and an efficient ventilation system in longwall coal mining. The formation of the gas emission zone and the potential amount of gas-in-place (GIP) that might be available for migration into a mine are factors of local geology and rock properties that usually show spatial variability in continuity and may also show geometric anisotropy. Geostatistical methods are used here for modeling and prediction of gas amounts and for assessing their associated uncertainty in gas emission zones of longwall mines for methane control. This study used core data obtained from 276 vertical exploration boreholes drilled from the surface to the bottom of the Pittsburgh coal seam in a mining district in the Northern Appalachian basin. After identifying important coal and non-coal layers for the gas emission zone, univariate statistical and semivariogram analyses were conducted for data from different formations to define the distribution and continuity of various attributes. Sequential simulations performed stochastic assessment of these attributes, such as gas content, strata thickness, and strata displacement. These analyses were followed by calculations of gas-in-place and their uncertainties in the Pittsburgh seam caved zone and fractured zone of longwall mines in this mining district. Grid blanking was used to isolate the volume over the actual panels from the entire modeled district and to calculate gas amounts that were directly related to the emissions in longwall mines. Results indicated that gas-in-place in the Pittsburgh seam, in the caved zone and in the fractured zone, as well as displacements in major rock units, showed spatial correlations that could be modeled and estimated using geostatistical methods. This study showed that GIP volumes may

  6. Positive affect and sleep in spousal Alzheimer caregivers: a longitudinal study.

    PubMed

    von Känel, Roland; Mausbach, Brent T; Ancoli-Israel, Sonia; Mills, Paul J; Dimsdale, Joel E; Patterson, Thomas L; Grant, Igor

    2014-09-03

    This article examines the longitudinal relation between positive affect (PA) and sleep in 126 spousal Alzheimer's disease caregivers. Caregivers underwent 4 yearly assessments for the Positive and Negative Affect Schedule, the self-rated Pittsburgh Sleep Quality Index, and actigraphy to objectify nighttime total sleep time, wake after sleep onset, and percentage of sleep. Increased levels of PA and a greater positivity (i.e., positive-to-negative affect) ratio were significantly associated with better subjective sleep over the entire study period. Yearly increases in PA-even when controlling for negative affect (NA)-and in the positivity ratio were also associated with better subjective sleep. PA and actigraphy measures showed no significant relations. Increased PA is longitudinally associated with better sleep in dementia caregivers largely independent of NA.

  7. 20. Zoo Substation. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. Zoo Substation. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 87.25. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  8. The 1985 pittsburgh conference: a special instrumentation report.

    PubMed

    1985-03-29

    For the first time in its 36 years of operation, the Pittsburgh Conference and Exposition on Analytical Chemistry and Applied Spectroscopy had a sharp drop in attendance-down 16 percent to 20,731. That loss was attributed to the fact that the meeting was held in New Orleans for the first time, and most of the lost attendees were students and young professionals who had previously come for only 1 day. The number of exhibitors and the number of booths, however, were both up about 15 percent, to 730 and 1856, respectively. A large proportion of that increase was contributed by foreign companies exhibiting for the first time, but there were also some well-known names, such as General Electric and Xerox, making first forays into analytical chemistry. There was also a sharp increase in the number and type of instruments displayed. "The key skill now in analytical chemistry," says Perkin-Elmer president Horace McDonell, Jr., "may be simply finding the right tool to obtain the answers you need." The predominant theme of the show, as it has been for the past few years, was automation of both laboratories and instruments. That trend is having major effects in chemical laboratories, but it is also affecting the instrument companies themselves. At large companies such as Varian, Beckman, and Perkin-Elmer, as much as 50 percent of the research and development budget is now going toward development of software-a much higher percentage than it was even 5 years ago. Another trend in automation also seemed clear at the show. As recently as 2 or 3 years ago, much of the available software for chemistry was designed for Apple and similar computers. Now, the laboratory standard is the IBM PC. As a representative of another company that manufactures computers noted with only slight exaggeration, "There's probably not a booth on the floor that doesn't have one."

  9. 23. North Philadelphia Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. North Philadelphia Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 84.55. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  10. 28. Poquessing Creek Bridge. Philadelphia, Philadelphia Co., PA. Sec. 1101, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. Poquessing Creek Bridge. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 74.20. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  11. 22. Schuylkill River Bridge. Philadelphia, Philadelphia Co., PA. Sec. 1101, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. Schuylkill River Bridge. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 87.14. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  12. 5. ISLAND ROAD BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. ISLAND ROAD BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, MP 5.58. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  13. 4. COBBS CREEK BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. COBBS CREEK BRIDGE. COLWYN, DELAWARE CO., PA. Sec. 1101, MP 5.73 - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  14. 27. Pennypack Creek Bridge. Philadelphia, Philadelphia Co., PA. Sec. 1101, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    27. Pennypack Creek Bridge. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 76.70. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  15. 21. Schuylkill River Bridge. Philadelphia, Philadelphia Co., PA. Sec. 1101, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. Schuylkill River Bridge. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 87.14. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  16. The Use of Video-Taped Lectures and Web-Based Communications in Teaching: A Distance-Teaching and Cross-Atlantic Collaboration Experiment.

    ERIC Educational Resources Information Center

    Herder, P. M.; Subrahmanian, E.; Talukdar, S.; Turk, A. L.; Westerberg, A. W.

    2002-01-01

    Explains distance education approach applied to the 'Engineering Design Problem Formulation' course simultaneously at the Delft University of Technology (the Netherlands) and at Carnegie Mellon University (CMU, Pittsburgh, USA). Uses video taped lessons, video conferencing, electronic mails and web-accessible document management system LIRE in the…

  17. Synergy of combined tPA-edaravone therapy in experimental thrombotic stroke.

    PubMed

    Sun, Yu-Yo; Morozov, Yury M; Yang, Dianer; Li, Yikun; Dunn, R Scott; Rakic, Pasko; Chan, Pak H; Abe, Koji; Lindquist, Diana M; Kuan, Chia-Yi

    2014-01-01

    Edaravone, a potent antioxidant, may improve thrombolytic therapy because it benefits ischemic stroke patients on its own and mitigates adverse effects of tissue plasminogen activator (tPA) in preclinical models. However, whether the combined tPA-edaravone therapy is more effective in reducing infarct size than singular treatment is uncertain. Here we investigated this issue using a transient hypoxia-ischemia (tHI)-induced thrombotic stroke model, in which adult C57BL/6 mice were subjected to reversible ligation of the unilateral common carotid artery plus inhalation of 7.5% oxygen for 30 min. While unilateral occlusion of the common carotid artery suppressed cerebral blood flow transiently, the addition of hypoxia triggered reperfusion deficits, endogenous thrombosis, and attenuated tPA activity, leading up to infarction. We compared the outcomes of vehicle-controls, edaravone treatment, tPA treatment at 0.5, 1, or 4 h post-tHI, and combined tPA-edaravone therapies with mortality rate and infarct size as the primary end-points. The best treatment was further compared with vehicle-controls in behavioral, biochemical, and diffusion tensor imaging (DTI) analyses. We found that application of tPA at 0.5 or 1 h--but not at 4 h post-tHI--significantly decreased infarct size and showed synergistic (p<0.05) or additive benefits with the adjuvant edaravone treatment, respectively. The acute tPA-edaravone treatment conferred >50% reduction of mortality, ∼ 80% decline in infarct size, and strong white-matter protection. It also improved vascular reperfusion and decreased oxidative stress, inflammatory cytokines, and matrix metalloproteinase activities. In conclusion, edaravone synergizes with acute tPA treatment in experimental thrombotic stroke, suggesting that clinical application of the combined tPA-edaravone therapy merits investigation.

  18. Synergy of Combined tPA-Edaravone Therapy in Experimental Thrombotic Stroke

    PubMed Central

    Sun, Yu-Yo; Morozov, Yury M.; Yang, Dianer; Li, Yikun; Dunn, R. Scott; Rakic, Pasko; Chan, Pak H.; Abe, Koji; Lindquist, Diana M.; Kuan, Chia-Yi

    2014-01-01

    Edaravone, a potent antioxidant, may improve thrombolytic therapy because it benefits ischemic stroke patients on its own and mitigates adverse effects of tissue plasminogen activator (tPA) in preclinical models. However, whether the combined tPA-edaravone therapy is more effective in reducing infarct size than singular treatment is uncertain. Here we investigated this issue using a transient hypoxia-ischemia (tHI)-induced thrombotic stroke model, in which adult C57BL/6 mice were subjected to reversible ligation of the unilateral common carotid artery plus inhalation of 7.5% oxygen for 30 min. While unilateral occlusion of the common carotid artery suppressed cerebral blood flow transiently, the addition of hypoxia triggered reperfusion deficits, endogenous thrombosis, and attenuated tPA activity, leading up to infarction. We compared the outcomes of vehicle-controls, edaravone treatment, tPA treatment at 0.5, 1, or 4 h post-tHI, and combined tPA-edaravone therapies with mortality rate and infarct size as the primary end-points. The best treatment was further compared with vehicle-controls in behavioral, biochemical, and diffusion tensor imaging (DTI) analyses. We found that application of tPA at 0.5 or 1 h – but not at 4 h post-tHI – significantly decreased infarct size and showed synergistic (p<0.05) or additive benefits with the adjuvant edaravone treatment, respectively. The acute tPA-edaravone treatment conferred >50% reduction of mortality, ∼80% decline in infarct size, and strong white-matter protection. It also improved vascular reperfusion and decreased oxidative stress, inflammatory cytokines, and matrix metalloproteinase activities. In conclusion, edaravone synergizes with acute tPA treatment in experimental thrombotic stroke, suggesting that clinical application of the combined tPA-edaravone therapy merits investigation. PMID:24911517

  19. Conference report: Clinical and Pharmaceutical Solutions through analysis (CPSA USA 2013): connecting patients and subject numbers through analysis.

    PubMed

    Needham, Shane; Premkumar, Noel; Weng, Naidong; Lee, Mike

    2014-02-01

    The 16th Annual Symposium on Clinical and Pharmaceutical Solutions through Analysis (CPSA) 7-10 October 2013, Sheraton Bucks County Hotel, Langhorne, PA, USA. The 2013 CPSA brought together the various US FDA regulated analytical fields affecting a 'patient' for the first time - bioanalysts supporting IND and NDAs, clinical diagnostic and pathology laboratory personnel, and clinical researchers that provide insights into new biomarkers. Although the regulatory requirements are different for each of the above disciplines, the unique analytical perspectives that affect the patient were shared - and the goal of the 2013 CPSA - 'Connecting Patients and Subject Numbers Through Analysis' was achieved.

  20. 18. Pennsylvania Railroad: Brick Arch Viaduct. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. Pennsylvania Railroad: Brick Arch Viaduct. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 87.44. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  1. 19. Pennsylvania Railroad: Brick Arch Viaduct. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. Pennsylvania Railroad: Brick Arch Viaduct. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 87.44. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  2. 94. FONTHILL (19081912), SOUTH ELEVATION. SAME VIEW AS PA10764. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    94. FONTHILL (1908-1912), SOUTH ELEVATION. SAME VIEW AS PA-107-64. - Moravian Pottery & Tile Works, Southwest side of State Route 313 (Swamp Road), Northwest of East Court Street, Doylestown, Bucks County, PA

  3. Crystal structure of the flavoenzyme PA4991 from Pseudomonas aeruginosa

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jacewicz, Agata; Schnell, Robert; Lindqvist, Ylva

    PA4991 is a FAD-dependent oxidoreductase from the pathogen P. aeruginosa that is essential for virulence and survival in the infected host. The structure of this enzyme, determined to 2.4 Å resolution, reveals that PA4991 belongs to the GR{sub 2} family of flavoenzymes. The locus PA4991 in Pseudomonas aeruginosa encodes an open reading frame that has been identified as essential for the virulence and/or survival of this pathogenic organism in the infected host. Here, it is shown that this gene encodes a monomeric FAD-binding protein of molecular mass 42.2 kDa. The structure of PA4991 was determined by a combination of molecularmore » replacement using a search model generated with Rosetta and phase improvement by a low-occupancy heavy-metal derivative. PA4991 belongs to the GR{sub 2} family of FAD-dependent oxidoreductases, comprising an FAD-binding domain typical of the glutathione reductase family and a second domain dominated by an eight-stranded mixed β-sheet. Most of the protein–FAD interactions are via the FAD-binding domain, but the isoalloxazine ring is located at the domain interface and interacts with residues from both domains. A comparison with the structurally related glycine oxidase and glycerol-3-phosphate dehydrogenase shows that in spite of very low amino-acid sequence identity (<18%) several active-site residues involved in substrate binding in these enzymes are conserved in PA4991. However, enzymatic assays show that PA4991 does not display amino-acid oxidase or glycerol-3-phosphate dehydrogenase activities, suggesting that it requires different substrates for activity.« less

  4. Morphological studies on block copolymer modified PA 6 blends

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Poindl, M., E-mail: marcus.poindl@ikt.uni-stuttgart.de, E-mail: christian.bonten@ikt.uni-stuttgart.de; Bonten, C., E-mail: marcus.poindl@ikt.uni-stuttgart.de, E-mail: christian.bonten@ikt.uni-stuttgart.de

    Recent studies show that compounding polyamide 6 (PA 6) with a PA 6 polyether block copolymers made by reaction injection molding (RIM) or continuous anionic polymerization in a reactive extrusion process (REX) result in blends with high impact strength and high stiffness compared to conventional rubber blends. In this paper, different high impact PA 6 blends were prepared using a twin screw extruder. The different impact modifiers were an ethylene propylene copolymer, a PA PA 6 polyether block copolymer made by reaction injection molding and one made by reactive extrusion. To ensure good particle matrix bonding, the ethylene propylene copolymermore » was grafted with maleic anhydride (EPR-g-MA). Due to the molecular structure of the two block copolymers, a coupling agent was not necessary. The block copolymers are semi-crystalline and partially cross-linked in contrast to commonly used amorphous rubbers which are usually uncured. The combination of different analysis methods like atomic force microscopy (AFM), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) gave a detailed view in the structure of the blends. Due to the partial cross-linking, the particles of the block copolymers in the blends are not spherical like the ones of ethylene propylene copolymer. The differences in molecular structure, miscibility and grafting of the impact modifiers result in different mechanical properties and different blend morphologies.« less

  5. 30 CFR 784.14 - Hydrologic information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Hydrologic information. 784.14 Section 784.14... Hydrologic information. (a) Sampling and analysis. All water quality analyses performed to meet the... Center, U.S. Department of the Interior, Building 10, Parkway Center, Pittsburgh, Pa.; at the OSM Western...

  6. 30 CFR 784.14 - Hydrologic information.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Hydrologic information. 784.14 Section 784.14... Hydrologic information. (a) Sampling and analysis. All water quality analyses performed to meet the... Center, U.S. Department of the Interior, Building 10, Parkway Center, Pittsburgh, Pa.; at the OSM Western...

  7. Where do food desert residents buy most of their junk food? Supermarkets.

    PubMed

    Vaughan, Christine A; Cohen, Deborah A; Ghosh-Dastidar, Madhumita; Hunter, Gerald P; Dubowitz, Tamara

    2017-10-01

    To examine where residents in an area with limited access to healthy foods (an urban food desert) purchased healthier and less healthy foods. Food shopping receipts were collected over a one-week period in 2013. These were analysed to describe where residents shopped for food and what types of food they bought. Two low-income, predominantly African-American neighbourhoods with limited access to healthy foods in Pittsburgh, PA, USA. Two hundred and ninety-three households in which the primary food shoppers were predominantly female (77·8 %) and non-Hispanic black (91·1 %) adults. Full-service supermarkets were by far the most common food retail outlet from which food receipts were returned and accounted for a much larger proportion (57·4 %) of food and beverage expenditures, both healthy and unhealthy, than other food retail outlets. Although patronized less frequently, convenience stores were notable purveyors of unhealthy foods. Findings highlight the need to implement policies that can help to decrease unhealthy food purchases in full-service supermarkets and convenience stores and increase healthy food purchases in convenience stores.

  8. Notification: Audit of Northwest Indian Fisheries Commission Puget Sound Protection and Restoration Implementation Grant Nos. PA00J32201 and PA00J91201

    EPA Pesticide Factsheets

    Project #OA-FY16-0176, May 13, 2016. The EPA OIG plans to begin preliminary research on an audit of the Northwest Indian Fisheries Commission (NWIFC) Puget Sound Protection and Restoration Implementation Grant Nos. PA00J32201 and PA00J91201.

  9. 77 FR 6587 - Startek USA, Inc. Alexandria, LA; Startek USA, Inc., Collinsville, VA; Amended Certification...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-08

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-75,089; TA-W-75,089A] Startek USA, Inc. Alexandria, LA; Startek USA, Inc., Collinsville, VA; Amended Certification Regarding Eligibility... for Worker Adjustment Assistance on January 26, 2011, applicable to workers of StarTek USA, Inc...

  10. Determinants of activity of the HIV-1 maturation inhibitor PA-457.

    PubMed

    Li, Feng; Zoumplis, Dorian; Matallana, Claudia; Kilgore, Nicole R; Reddick, Mary; Yunus, Abdul S; Adamson, Catherine S; Salzwedel, Karl; Martin, David E; Allaway, Graham P; Freed, Eric O; Wild, Carl T

    3-O-(3',3'-dimethylsuccinyl) betulinic acid, also termed PA-457 or DSB, is a novel HIV-1 inhibitor that blocks virus maturation by disrupting cleavage of the capsid precursor, CA-SP1. To better define the molecular target for PA-457, we prepared a panel of mutant viruses with point deletions spanning the CA-SP1 cleavage domain and characterized each of these viruses for PA-457 sensitivity. Our results indicate that amino acid residues in the N-terminal half of SP1 serve as determinants of PA-457 activity, while residues in the C-terminal half of SP1 were not involved in compound activity. These findings support and extend previous observations that PA-457 is a specific inhibitor of CA-SP1 cleavage and identify the CA-SP1 domain as the primary viral determinant for this novel inhibitor of HIV-1 replication.

  11. The Effect of Added AL2O3 on the Propagation Behavior of an Al/CuO Nanoscale Thermite

    DTIC Science & Technology

    2008-01-01

    Malchi a, Richard A. Yetter a,*, T. J. Foley b, and Steven F. Son c a The Pennsylvania State University, University Park, PA, USA b Los Alamos National...Laboratory, Los Alamos, NM, USA c Purdue University, West Lafayette, IN, USA U. S. Army Research Office P.O. Box 12211 Research Triangle Park, NC...Pennsylvania State University, University Park, PA, USA b Los Alamos National Laboratory, Los Alamos, NM, USA c Purdue University, West Lafayette, IN, USA

  12. Identification of PaCOL1 and PaCOL2, two CONSTANS-like genes showing decreased transcript levels preceding short day induced growth cessation in Norway spruce.

    PubMed

    Holefors, Anna; Opseth, Lars; Ree Rosnes, Anne Katrine; Ripel, Linda; Snipen, Lars; Fossdal, Carl Gunnar; Olsen, Jorunn E

    2009-02-01

    In woody plants of the temperate zone short photoperiod (SD) leads to growth cessation. In angiosperms CONSTANS (CO) or CO-like genes play an important role in the photoperiodic control of flowering, tuberisation and shoot growth. To investigate the role of CO-like genes in photoperiodic control of shoot elongation in gymnosperms, PaCOL1 and PaCOL2 were isolated from Norway spruce. PaCOL1 encodes a 3.9kb gene with a predicted protein of 444 amino acids. PaCOL2 encodes a 1.2kb gene with a predicted protein of 385 amino acids. Both genes consist of two exons and have conserved domains found in other CO-like genes; two zinc finger domains, a CCT and a COOH domain. PaCOL1 and PaCOL2 fall into the group 1c clade of the CO-like genes, and are thus distinct from Arabidopsis CO that belongs to group 1a. Transcript levels of both PaCOL-genes appear to be light regulated, an increasing trend was observed upon transition from darkness to light, and a decreasing trend during darkness. The increasing trend at dawn was observed both in needles and shoot tips, whereas the decreasing trend in darkness was most prominent in shoot tips, and limited to the late part of the dark period in needles. The transcript levels of both genes decreased significantly in both tissues under SD prior to growth cessation and bud formation. This might suggest an involvement in photoperiodic control of shoot elongation or might be a consequence of regulation by light.

  13. tPA variant tPA-A296-299 Prevents impairment of cerebral autoregulation and necrosis of hippocampal neurons after stroke by inhibiting upregulation of ET-1.

    PubMed

    Armstead, William M; Hekierski, Hugh; Yarovoi, Serge; Higazi, Abd Al-Roof; Cines, Douglas B

    2018-01-01

    Tissue-type plasminogen activator (tPA) is neurotoxic and exacerbates uncoupling of cerebral blood flow (CBF) and metabolism after stroke, yet it remains the sole FDA-approved drug for treatment of ischemic stroke. Upregulation of c-Jun-terminal kinase (JNK) after stroke contributes to tPA-mediated impairment of autoregulation, but the role of endothelin-1 (ET-1) is unknown. Based on the Glasgow Coma Scale, impaired autoregulation is linked to adverse outcomes after TBI, but correlation with hippocampal histopathology after stroke has not been established. We propose that given after stroke, tPA activates N-Methyl-D-Aspartate receptors (NMDA-Rs) and upregulates ET-1 in a JNK dependent manner, imparing autoregulation and leading to histopathology. After stroke, CBF was reduced in the hippocampus and reduced further during hypotension, which did not occur in hypotensive sham pigs, indicating impairment of autoregulation. Autoregulation and necrosis of hippocampal CA1 and CA3 neurons were further impaired by tPA, but were preserved by the ET-1 antagonist BQ 123 and tPA-A, 296-299 a variant that is fibrinolytic but does not bind to NMDA-Rs. Expression of ET-1 was increased by stroke and potentiated by tPA but returned to sham levels by tPA-A 296-299 and the JNK antagonist SP600125. Results show that JNK releases ET-1 after stroke. Tissue-type plasminogen activator -A 296-299 prevents impairment of cerebral autoregulation and histopathology after stroke by inhibiting upregulation of ET-1. © 2017 Wiley Periodicals, Inc.

  14. MRSA USA300 at Alaska Native Medical Center, Anchorage, Alaska, USA, 2000–2006

    PubMed Central

    Rudolph, Karen M.; Hennessy, Thomas W.; Zychowski, Diana L.; Asthi, Karthik; Boyle-Vavra, Susan; Daum, Robert S.

    2012-01-01

    To determine whether methicillin-resistant Staphylococcus aureus (MRSA) USA300 commonly caused infections among Alaska Natives, we examined clinical MRSA isolates from the Alaska Native Medical Center, Anchorage, during 2000–2006. Among Anchorage-region residents, USA300 was a minor constituent among MRSA isolates in 2000–2003 (11/68, 16%); by 2006, USA300 was the exclusive genotype identified (10/10). PMID:22264651

  15. The story of an exceptional serine protease, tissue-type plasminogen activator (tPA).

    PubMed

    Hébert, M; Lesept, F; Vivien, D; Macrez, R

    2016-03-01

    The only acute treatment of ischemic stroke approved by the health authorities is tissue recombinant plasminogen activator (tPA)-induced thrombolysis. Under physiological conditions, tPA, belonging to the serine protease family, is secreted by endothelial and brain cells (neurons, astrocytes, microglia, oligodendrocytes). Although revascularisation induced by tPA is beneficial during a stroke, research over the past 20 years shows that tPA can also be deleterious for the brain parenchyma. Thus, in this review of the literature, after a brief history on the discovery of tPA, we reviewed current knowledge of mechanisms by which tPA can influence brain function in physiological and pathological conditions. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  16. Functionalization and Melt-compounding of MWCNTs in PA-6 for Tribological Applications

    NASA Astrophysics Data System (ADS)

    Chopra, Swamini; Deshmukh, Kavita A.; Deshmukh, Abhay D.; Peshwe, D. R.

    2018-04-01

    The present study focuses on the fabrication and mechanical property evaluation of PA-6/MWCNT nanocomposites reinforced with microwave-functionalized MWCNTs. The MWCNTs were subjected to microwave radiation in the solution of H2SO4 and HNO3 for 3 minutes, with the aim of achieving better and faster functionalization. The change observed in the crystal structure of PA-6 matrix after CNT addition suggested improved nucleation due to well-dispersed MWCNTs after functionalization. The tensile strength of PA-6 increased by approx. 12 % and 15 % after addition of pristine and functionalized MWCNTs, respectively. This was credited to improved interaction between CNTs and PA-6 matrix. The dispersion quality of CNTs in PA-6 matrix was verified by FEG-SEM, while the fractography of composites revealed polymer sheathing of PA-6 matrix around CNTs. This again contributed in improving the elongation of the composites by approx. 10 %. The wear resistance of the composites also improved appreciably, irrespective of the applied load. The specific wear rate of PA-6/CNT nanocomposite reinforced with functionalized MWCNTs increased by approx. 60 to 70 %, while coefficient of friction reduced by approx. 30 to 40%.

  17. Overexpression of PaFT gene in the wild orchid Phalaenopsis amabilis (L.) Blume

    NASA Astrophysics Data System (ADS)

    Semiarti, Endang; Mercuriani, Ixora S.; Rizal, Rinaldi; Slamet, Agus; Utami, Bekti S.; Bestari, Ida A.; Aziz-Purwantoro, Moeljopawiro, S.; Jang, Soenghoe; Machida, Y.; Machida, C.

    2015-09-01

    To shorten vegetative stage and induce transition from vegetative to reproductive stage in orchids, we overexpressed Phalaenopsis amabilis Flowering LocusT (PaFT) gene under the control of Ubiquitin promoter into protocorm of Indonesian Wild Orchid Phalaenopsis amabilis (L.) Blume. The dynamic expression of vegetative gene Phalaenopsis Homeobox1 (POH1) and flowering time gene PaFT has been analyzed. Accumulation of mRNA was detected in shoot and leaves of both transgenic and non transgenic plants by using Reverse transcriptase-PCR (RT-PCR) with specific gene primers for POH1 and PaFT in 24 months old plants. To analyze the POH1 and PaFT genes, three pairs of degenerate primers PaFT degF1R1, F2R2 and F3R3 that amplified 531 bp PaFT cDNA were used. We detected 700 bp PaFTcDNA from leaves and shoots of transgenic plants, but not in NT plants. POH1 mRNA was detected in plants. PaFT protein consists of Phospatidyl Ethanolamine-Binding Protein (PEBP) in interval base 73-483 and CETS family protein at base 7-519, which are important motif for transmembrane protein. We inserted Ubipro::PaFT/pGAS101 into P. amabilis protocorm using Agrobacterium. Analysis of transgenic plants showed that PaFTmRNA was accumulated in leaves of 12 months after sowing, although it is not detected in non transgeic plants. Compare to the wild type (NT plants), ectopic expression of PaFT shows alter phenotype as follows: 31% normal, 19% with short-wavy leaves, 5% form rosette leaves and 45% produced multishoots. Analysis of protein profiles of trasgenic plants showed that a putative PaFT protein (MW 19,7 kDa) was produced in 1eaves and shoots.This means that at 12 months, POH1 gene expression gradually decreased/negatively regulated, the expression of PaFT gene was activated, although there is no flower initiation yet. Some environmental factors might play a role to induce inflorescens. This experiment is in progress.

  18. PERSPECTIVE VIEW OF FRONT ELEVATION OF PYTHIAN TEMPLE/NEW GRANADA THEATER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PERSPECTIVE VIEW OF FRONT ELEVATION OF PYTHIAN TEMPLE/NEW GRANADA THEATER FROM NORTHEAST. THIS 1927 STRUCTURE WAS DESIGNED BY ARCHITECT LOUIS A. BELLINGER FOR THE KNIGHTS OF PYTHIAS. IT WAS CONVERTED INTO THE NEW GRANADA THEATER DURING THE 1930S. - Pythian Temple, 2007-2013 Centre Avenue, Pittsburgh, Allegheny County, PA

  19. ENDOCRINE MODULATING EFFECTS OF LAGOON WATER FROM CONFINED ANIMAL FEED OPERATIONS ON AMPHIBIANS

    EPA Science Inventory


    Endocrine Modulating Effects of Lagoon Water from Confined Animal Feed Operations on Amphibians. Weber, L.P.*1, Dumont, J.N.1, Selcer, K.W.2, Hutchins, S.R.3, and Janz, D.M.1 1Oklahoma State University, Stillwater, OK, 2Duquesne University, Pittsburgh, PA, 3U.S. Environmenta...

  20. 76 FR 13234 - Investigations Regarding Certifications of Eligibility To Apply for Worker Adjustment Assistance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    .../11/11. Inc. including employees who work from home in WV (Company). 75262 Highmark, including Camp Hill, PA......... 02/14/11 02/11/11. locations in Pittsburgh, Erie, Johnstown & Wkrs from home (Company...). 75269 Evergreen Solar, Inc. Devens, MA 02/14/11 02/11/11. (Company). 75270 Sterling Life Insurance...

  1. Mitochondrial Disease: Possible Symptoms

    MedlinePlus

    ... problems Fatigue Short stature Contact Us 8085 Saltsburg Road, Suite 201 Pittsburgh, PA 15239 1-888-317-UMDF P 412-793-8077 F 412-793-6477 info@umdf.org The UMDF Mission Our mission: To promote research and education for the diagnosis, treatment, and cure of mitochondrial disorders and to ...

  2. Admissions and Plebe Year Data as Indicators of Academic Success in Engineering Majors at the United States Naval Academy

    DTIC Science & Technology

    2002-06-01

    3 = Divorced ) Number of Dependents Self-Explanatory Continuous Variable Related Job Experience Was job experience related to college program...Crawford Naval Postgraduate School Monterrey , CA 7. Professor Roger Little U. S. Naval Academy Annapolis, MD 8. LT Nicholas A. Kristof Chester, MD 9. Mr. and Mrs. Zoltan J. Kristof Pittsburgh, PA

  3. Children’s Hospital of Pittsburgh and Diabetes Institute of the Walter Reed Health Care System Genetic Screening in Diabetes: Candidate Gene Analysis for Diabetic Retinopathy

    DTIC Science & Technology

    2008-05-22

    available and consents to be in the study. • In addition to referrals from Diabetes Institute nurse practitioners, endocrinologists, and diabetes ...coronary artery disease in juvenile - onset, insulin dependent diabetes mellitus. Am J Cardiol. 59:750-755, 1987a. Krolewski AS, Warram JH, Rand LI...1-0313 TITLE: Children’s Hospital of Pittsburgh and Diabetes Institute of the Walter Reed Health Care System Genetic Screening in

  4. 76 FR 59503 - Establishment of Class E Airspace; Lebanon, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ... at Lebanon, PA, to accommodate new Standard Instrument Approach Procedures that have been developed... of the airport. This action enhances the safety and management of Instrument Flight Rules (IFR... support new standard instrument approach procedures developed at Keller Brothers Airport, Lebanon, PA. The...

  5. 32 CFR 701.123 - PA fees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... duplication for free. (1) DON activities shall waive fees automatically if the direct cost for reproduction of... made on a case-to-case basis. (c) PA fee deposits. Checks or money orders shall be made payable to the...

  6. 32 CFR 701.123 - PA fees.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... duplication for free. (1) DON activities shall waive fees automatically if the direct cost for reproduction of... made on a case-to-case basis. (c) PA fee deposits. Checks or money orders shall be made payable to the...

  7. 32 CFR 701.123 - PA fees.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... duplication for free. (1) DON activities shall waive fees automatically if the direct cost for reproduction of... made on a case-to-case basis. (c) PA fee deposits. Checks or money orders shall be made payable to the...

  8. 32 CFR 701.123 - PA fees.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... duplication for free. (1) DON activities shall waive fees automatically if the direct cost for reproduction of... made on a case-to-case basis. (c) PA fee deposits. Checks or money orders shall be made payable to the...

  9. 32 CFR 701.123 - PA fees.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... duplication for free. (1) DON activities shall waive fees automatically if the direct cost for reproduction of... made on a case-to-case basis. (c) PA fee deposits. Checks or money orders shall be made payable to the...

  10. Bilateral key comparison CCM.P-K3.1 for absolute pressure measurements from 3 × 10-6 Pa to 9 × 10-4 Pa

    NASA Astrophysics Data System (ADS)

    Fedchak, J. A.; Bock, Th; Jousten, K.

    2014-01-01

    This report describes the bilateral key comparison CCM.P-K3.1 between the National Institute of Standards and Technology (NIST) and Physikalisch-Technische Bundesanstalt (PTB) for absolute pressure in the range from 3 × 10-6 Pa to 9 × 10-4 Pa. This comparison was a follow-up to the comparison CCM.P-K3. Two ionization gauges and two spinning rotor gauges (SRGs) were used as the transfer standards for the comparison. The SRGs were used to compare the standards at a pressure of 9 × 10-4 Pa and to normalize the ionization gauge readings. The two ionization gauges were used to compare the standards in the pressure range of from 3 × 10-6 Pa to 3 × 10-4 Pa. Both laboratories used dynamic expansion chambers as standards in the comparison. The two labs showed excellent agreement with each other and with the CCM.P-K3 key comparison reference value (KCRV) over the entire range. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  11. The application of PA/CF in stab resistance body armor

    NASA Astrophysics Data System (ADS)

    Yuan, M. Q.; Liu, Y.; Gong, Z.; Qian, X. M.

    2017-06-01

    Stab resistance body armor (SRBA) is an essential defensive equipment to protect human body against injuries from stabbing. The conventional SRBAs shared low wearing frequency since they are heavy and poor in flexibility. This paper designed a structured stab-resistance plate using the model of crocodile armor and manufactured using 3D printing technology-laser sintering (LS). CF(Carbon fiber) was applied to enhance the stab resistance properties of SRBA. The effects of the material and structure were analysed through the stab resistance property tests based on the national standard GA68-2008. It is found that the stab resistance property of flat plates sintered by PA powder and PA/CF are both weaker than that of the structured plate. The penetrating depth of PA/CF structured plate is significantly 2-mm-less than the pure PA structured plate. The SEM observations confirmed the conclusion that addition of the CF largely improved the plate stab resistance property. Moreover, using PA/CF structured plate to produce the stab resistance body armor would result in a weight reduction by about 30-40% as compared to the existing SRBA that was made up of metal plates, which could largely reduce the wearer physical burden and improve the wearing frequency.

  12. Tissue plasminogen activator (tPA) as a reporter gene in transient gene expression.

    PubMed

    Cheng, S M; Lee, S G; Kalyan, N K; McCloud, S; Levner, M; Hung, P P

    1987-01-01

    Using the gene coding for tissue plasminogen activator (tPA) as a reporter gene, a transient gene expression system has been established. Vectors containing the full-length cDNA of tPA with its signal sequences were introduced into mammalian recipient cells by a modified gene transfer procedure. Thirty hours after transfection, the secreted tPA was found in serum-free medium and measured by a fibrin-agarose plate assay (FAPA). In this assay, tPA converts plasminogen into plasmin which then degrades high-Mr fibrin to produce cleared zones. The sizes of these zones correspond to quantities of tPA. The combination of transient tPA expression system and the FAPA provides a quick, sensitive, quantitative and non-destructive method to examine the strength of eukaryotic regulatory elements in tissue-culture cells.

  13. Hardgrove grindability study of Powder River Basin and Appalachian coal components in the blend to a midwestern power station

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Padgett, P.L.; Hower, J.C.

    1996-12-31

    Five coals representing four distinct coal sources blended at a midwestern power station were subjected to detailed analysis of their Hardgrove grindability. The coals are: a low-sulfur, high volatile A bituminous Upper Elkhorn No. 3 coal (Pike County, KY); a medium-sulfur, high volatile A bituminous Pittsburgh coal (southwestern PA); a low-sulfur, subbituminous Wyodak coal from two mines in the eastern Powder River Basin (Campbell County, WY). The feed and all samples processed in the Hardgrove grindability test procedure were analyzed for their maceral and microlithotype content. The high-vitrinite Pittsburgh coal and the relatively more petrographically complex Upper Elkhorn No. 3more » coal exhibit differing behavior in grindability. The Pittsburgh raw feed, 16x30 mesh fraction (HGI test fraction), and the {minus}30 mesh fraction (HGI reject) are relatively similar petrographically, suggesting that the HGI test fraction is reasonably representative of the whole feed. The eastern Kentucky coal is not as representative of the whole feed, the HGI test fraction having lower vitrinite than the rejected {minus}30 mesh fraction. The Powder River Basin coals are high vitrinite and show behavior similar to the Pittsburgh coal.« less

  14. 47 CFR 90.631 - Trunked systems loading, construction and authorization requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... authorization requirements. (a) Non-SMR trunked systems will be authorized on the basis of a loading criteria of... minimum of seventy (70) mobiles for each channel authorized will be placed into operation within five (5...; Washington, DC; Dallas-Fort Worth, TX; Miami, FL; Cleveland, OH; St. Louis, MO; Atlanta, GA; Pittsburgh, PA...

  15. 68. (Credit JTL) Front view of one of the many ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    68. (Credit JTL) Front view of one of the many marble benches used in the filter rooms for housing meters and filter controls. These were built by F.R. Leopold, Inc. of Pittsburgh, PA and installed in 1924-26. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

  16. High-Resolution Forest Carbon Monitoring and Modeling: Continued Prototype Development and Deployment Across The Tri-state Area (MD, PA, DE), USA

    NASA Astrophysics Data System (ADS)

    Hurtt, G. C.; Birdsey, R.; Campbell, E.; Dolan, K. A.; Dubayah, R.; Escobar, V. M.; Finley, A. O.; Flanagan, S.; Huang, W.; Johnson, K.; Lister, A.; ONeil-Dunne, J.; Sepulveda Carlo, E.; Zhao, M.

    2017-12-01

    Local, national and international programs have increasing need for precise and accurate estimates of forest carbon and structure to support greenhouse gas reduction plans, climate initiatives, and other international climate treaty frameworks. In 2010 Congress directed NASA to initiate research towards the development of Carbon Monitoring Systems (CMS). In response, our team has worked to develop a robust, replicable framework to produce maps of high-resolution carbon stocks and future carbon sequestration potential. High-resolution (30m) maps of carbon stocks and uncertainty were produced by linking national 1m-resolution imagery and existing wall-to-wall airborne lidar to spatially explicit in-situ field observations such as the USFS Forest Inventory and Analysis (FIA) network. These same data, characterizing forest extent and vertical structure, were used to drive a prognostic ecosystem model to predict carbon fluxes and carbon sequestration potential at unprecedented spatial resolution and scale (90m), more than 100,000 times the spatial resolution of standard global models. Through project development, the domain of this research has expanded from two counties in MD (2,181 km2), to the entire state (32,133 km2), to the tri-state region of MD, PA, and DE (157,868 km2), covering forests in four major USDA ecological providences (Eastern Broadleaf, Northeastern Mixed, Outer Coastal Plain, and Central Appalachian). Across the region, we estimate 694 Tg C (14 DE, 113 MD, 567 PA) in above ground biomass, and estimate a carbon sequestration potential more than twice that amount. Empirical biomass products enhance existing approaches though high resolution accounting for trees outside traditional forest maps. Modeling products move beyond traditional MRV, and map future afforestation and reforestation potential for carbon at local actionable spatial scales. These products are relevant to multiple stakeholder needs in the region as discussed through the Tri

  17. 11. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  18. 12. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  19. 16. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  20. 9. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  1. 10. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  2. 14. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  3. 15. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  4. 13. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  5. 17. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. Pennsylvania Railroad: 30th Street Station. Philadelphia, Philadelphia Co., PA. Sec. 1101, MP 88.10. - Northeast Railroad Corridor, Amtrak route between Delaware-Pennsylvania & Pennsylvania-New Jersey state lines, Philadelphia, Philadelphia County, PA

  6. HoPaCI-DB: host-Pseudomonas and Coxiella interaction database

    PubMed Central

    Bleves, Sophie; Dunger, Irmtraud; Walter, Mathias C.; Frangoulidis, Dimitrios; Kastenmüller, Gabi; Voulhoux, Romé; Ruepp, Andreas

    2014-01-01

    Bacterial infectious diseases are the result of multifactorial processes affected by the interplay between virulence factors and host targets. The host-Pseudomonas and Coxiella interaction database (HoPaCI-DB) is a publicly available manually curated integrative database (http://mips.helmholtz-muenchen.de/HoPaCI/) of host–pathogen interaction data from Pseudomonas aeruginosa and Coxiella burnetii. The resource provides structured information on 3585 experimentally validated interactions between molecules, bioprocesses and cellular structures extracted from the scientific literature. Systematic annotation and interactive graphical representation of disease networks make HoPaCI-DB a versatile knowledge base for biologists and network biology approaches. PMID:24137008

  7. Ask Here PA: Large-Scale Synchronous Virtual Reference for Pennsylvania

    ERIC Educational Resources Information Center

    Mariner, Vince

    2008-01-01

    Ask Here PA is Pennsylvania's new statewide live chat reference and information service. This article discusses the key strategies utilized by Ask Here PA administrators to recruit participating libraries to contribute staff time to the service, the importance of centralized staff training, the main aspects of staff training, and activating the…

  8. The Orion Pad Abort 1 (PA-1) Flight Test: A Propulsion Success

    NASA Technical Reports Server (NTRS)

    Jones, Daniel S.

    2015-01-01

    This poster provides a concise overview of the highly successful Orion Pad Abort 1 (PA-1) flight test, and the three rocket motors that contributed to this success. The primary purpose of the Orion PA-1 flight was to help certify the Orion Launch Abort System (LAS), which can be utilized in the unlikely event of an emergency on the launchpad or during mission vehicle ascent. The PA-1 test was the first fully integrated flight test of the Orion LAS, one of the primary systems within the Orion Multi-Purpose Crew Vehicle (MPCV). The Orion MPCV is part of the architecture within the Space Launch System (SLS), which is being designed to transport astronauts beyond low-Earth orbit for future exploration missions. Had the Orion PA-1 flight abort occurred during launch preparations for a real human spaceflight mission, the PA-1 LAS would have saved the lives of the crew. The PA-1 flight test was largely successful due to the three solid rocket motors of the LAS: the Attitude Control Motor (ACM); the Jettison Motor (JM); and the Abort Motor (AM). All three rocket motors successfully performed their required functions during the Orion PA-1 flight test, flown on May 6, 2010 at the White Sands Missile Range in New Mexico, culminating in a successful demonstration of an abort capability from the launchpad.

  9. Orion Launch Abort System (LAS) Propulsion on Pad Abort 1 (PA-1)

    NASA Technical Reports Server (NTRS)

    Jones, Daniel S.

    2015-01-01

    This presentation provides a concise overview of the highly successful Orion Pad Abort 1 (PA-1) flight test, and the three rocket motors that contributed to this success. The primary purpose of the Orion PA-1 flight was to help certify the Orion Launch Abort System (LAS), which can be utilized in the unlikely event of an emergency on the launchpad or during mission vehicle ascent. The PA-1 test was the first fully integrated flight test of the Orion LAS, one of the primary systems within the Orion Multi-Purpose Crew Vehicle (MPCV). The Orion MPCV is part of the architecture within the Space Launch System (SLS), which is being designed to transport astronauts beyond low-Earth orbit for future exploration missions. Had the Orion PA-1 flight abort occurred during launch preparations for a real human spaceflight mission, the PA-1 LAS would have saved the lives of the crew. The PA-1 flight test was largely successful due to the three solid rocket motors of the LAS: the Attitude Control Motor (ACM); the Jettison Motor (JM); and the Abort Motor (AM). All three rocket motors successfully performed their required functions during the Orion PA-1 flight test, flown on May 6, 2010 at the White Sands Missile Range in New Mexico, culminating in a successful demonstration of an abort capability from the launchpad.

  10. "Food is directed to the area": African Americans' perceptions of the neighborhood nutrition environment in Pittsburgh.

    PubMed

    Kumar, Supriya; Quinn, Sandra C; Kriska, Andrea M; Thomas, Stephen B

    2011-01-01

    Studies have shown racial disparities in neighborhood access to healthy food in the United States. We used a mixed methods approach employing geographic information systems, focus groups, and a survey to examine African Americans' perceptions of the neighborhood nutrition environment in Pittsburgh. We found that African Americans perceive that supermarkets serving their community offer produce and meats of poorer quality than branches of the same supermarket serving White neighborhoods (p<0.001). Unofficial taxis or jitneys, on which many African Americans are reliant, provide access from only certain stores; people are therefore forced to patronize these stores even though they are perceived to be of poorer quality. Community-generated ideas to tackle the situation include ongoing monitoring of supermarkets serving the Black community. We conclude that stores should make every effort to be responsive to the perceptions and needs of their clients and provide an environment that enables healthy eating. Copyright © 2010 Elsevier Ltd. All rights reserved.

  11. EnviroAtlas - Pittsburgh, PA - Domestic Water Use per Day by U.S. Census Block Group

    EPA Pesticide Factsheets

    As included in this EnviroAtlas dataset, the community level domestic water use was calculated using locally available water use data per capita in gallons of water per day (GPD), distributed dasymetrically, and summarized by census block group. Domestic water use, as defined in this case, is intended to represent residential indoor and outdoor water use (e.g., cooking hygiene, landscaping, pools, etc.) for primary residences (i.e., excluding second homes and tourism rentals). For the purposes of this metric, these publicly-supplied estimates are also applied and considered representative of local self-supplied water use. Domestic water demand was calculated and applied using the Pennsylvania Department of Environmental Protection (PADEP) PWS Service Areas layer, population served per provider, and average water use per provider. Within the EnviroAtlas study area, there are 43 service providers with 2010-2013 estimates ranging from 34 to 102 GPD.This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can

  12. Exploratory evidence on the market for effective depression care in Pittsburgh.

    PubMed

    Schoenbaum, Michael; Kelleher, Kelly; Lave, Judith R; Green, Stephanie; Keyser, Donna; Pincus, Harold

    2004-04-01

    Despite the existence of effective and relatively cost-effective depression treatments, many depressed patients do not receive appropriate care. The authors assessed opportunities for increasing the rate of effective depression treatment by investigating the market for such treatment in the Pittsburgh area. A conceptual framework was developed to evaluate the market for effective depression care. On the basis of the conceptual framework, interviews were conducted with representatives from seven large employers, two medical health insurance carriers, two behavioral health insurance carriers, four primary care providers, and four behavioral health care providers. Respondents were asked to assess the barriers to and opportunities for increasing the rates of depression treatment from their perspectives. The findings suggest that there is currently little demand among purchasers for improving depression care and little interest among insurers and providers for improving care in the absence of purchaser demand. Even stakeholders who identified depression as an important problem could not come to a consensus about who should be responsible for addressing the problem. Employers reported that they look primarily to their vendors to initiate quality improvement efforts, whereas insurers reported that such improvement efforts were more likely to occur if they were initiated by employers who purchase their health plans; providers, in turn, reported feeling powerless to initiate change. The absence of a clear locus of responsibility for improving depression care lends considerable inertia to the status quo. Because the currently low treatment rates are likely to be socially inefficient, researchers and policy makers should consider strategies to help overcome this inertia.

  13. Reconstruction of the 1994 Pittsburgh Airplane Accident Using a Computer Simulation

    NASA Technical Reports Server (NTRS)

    Parks, Edwin K.; Bach, Ralph E., Jr.; Shin, Jae Ho

    1998-01-01

    On September 8, 1994, a Boeing 737-300 passenger airplane was on a downwind approach to the Pittsburgh International Airport at an altitude of 5000 feet above ground level (6000 feet MSL). While in a shallow left turn onto a downwind approach heading, the airplane crossed into the vortex trail of a Boeing 727 flying in the same approach pattern about 4 miles ahead. The B-737 airplane rolled and turned sharply to the left, exited the vortex wake and plunged into the ground. Weather was not a factor in the accident. The airplane was equipped with a 11+ channel digital Flight Data Recorder (FDR) and a multiple channel Cockpit Voice Recorder (CVR). Both recorders were recovered from the crash site and provided excellent data for the development of an accident scenario. Radar tracking of the two airplanes as well as the indicated air speed (IAS) perturbations clearly visible on the B-737 FDR recordings indicate that the upset was apparently initiated by the airplane's crossing into the wake of the B-727 flying ahead in the same traffic pattern. A 6 degree-of-freedom simulation program for the B-737 airplane using MATLAB and SIMULINK was constructed. The simulation was initialized at the stabilized flight conditions of the airplane about 13 seconds prior to its entry into the vortex trail of the B-727 airplane. By assuming a certain combination of control inputs, it was possible to produce a simulated motion that closely matched that recorded on the FDR.

  14. The Case For Prediction-based Best-effort Real-time Systems.

    DTIC Science & Technology

    1999-01-01

    Real - time Systems Peter A. Dinda Loukas Kallivokas January...DISTRIBUTION STATEMENT A Approved for Public Release Distribution Unlimited DTIG QUALBR DISSECTED X The Case For Prediction-based Best-effort Real - time Systems Peter...Mellon University Pittsburgh, PA 15213 A version of this paper appeared in the Seventh Workshop on Parallel and Distributed Real - Time Systems

  15. Automated Laser Depainting of Aircraft Survey of Enabling Technologies

    DTIC Science & Technology

    1991-01-01

    Dreyer (414)785-3400 AEG PO Box 160 Pittsburgh, PA 16230 Advanced Mmnu&chuig Systems 6075 The Corners Parkway Norcrou, GA 48120 (404)448-6700...M9L ZW7 (416)745-9630 TOKICO 1203 Commerce Drive South Dearborn, MI 48120 (313)33.-•280 US Air Force Sacramento Air Logistics Center McClellan Air

  16. 230Thand 231Pa in Seawater Sinking Particles from the North Atlantic GEOTRACES Transect

    NASA Astrophysics Data System (ADS)

    LU, Y.; Edwards, R. L.; Cheng, H.; Anderson, R. F.; Hayes, C. T.; Fleisher, M. Q.; Lam, P. J.; Huang, K. F.; Robinson, L. F.; Wang, X.

    2016-12-01

    The biological carbon pump in the ocean plays a key role in regulating atmospheric CO2 level via oceanic particle dynamics. Radionuclides with proper half-lives, like 230Th and 231Pa, can provide quantitative estimates of particle cycling on the timescales up to hundred thousand years. However, our understanding of particle dynamics is hindered by the difficulty in precisely determining particulate 230Th and 231Pa, due to the trace amounts of Th and Pa in seawater, especially in large sinking particles. Here, we developed a technique to measure sinking particulate 230Th and 231Pa in a small sample size (tens to hundreds attograms of 231Pa, equivalent to 100 L water pumped through QMA filter), and achieved an average precision in percentage level. We firstly applied leaching processes to the particulate samples. The samples were soaked in 8N HNO3 + 0.5N HF mixed with proportionally determined 229Th and 233Pa spikes, and heated at 100°C for 10 hours. Th and Pa were then pre-concentrated by co-precipitation with Fe. After HNO3-HClO4-HNO3 digestion of the precipitates, Th and Pa were separated and purified using anion exchange chromatography (Spectra/Gel anion resin 1x8). Pa was measured on a MC-ICP-MS instrument (Neptune) right after the chemistry in order to minimize the 233Pa "bleeding effect". Replication tests show a good agreement in 231Pa/230Th within the measurement uncertainties. Applying our method to the profile samples collected from the North Atlantic GEOTRACES Transect, we found that the concentrations of 230Th and 231Pa in sinking particles (>51 μm size fraction; attograms/liter) are about 1/10 of those in suspended ones (1 - 51 μm size fraction). The scavenging of Th and Pa to large particles appears to be a function of particle composition (CaCO3, POM, lithogenic, opal and Fe/Mn oxides). In addition, ratios of the adsorbed 231Pa to 230Th are the same in both types of particles, although the particles have significantly different residence time in

  17. Shuttle GPS R/PA configuration and specification study

    NASA Technical Reports Server (NTRS)

    Booth, R. W. D.

    1979-01-01

    Changes in the technical specifications for a global positioning system (GPS) receiving system dedicated to space shuttle use are presented. Various hardware functions including acquisition, tracking, and measurement are emphasized. The anti-jam performance of the baseline GPS systems are evaluated. Other topics addressed include: the impact on R/PA design of the use of ground based transmitters; problems involved with the use of single channel tests sets; utility of various R/PA antenna interconnections topologies; the choice of the averaging interval for delta range measurements; and the use of interferometry techniques for the computation of orbiter attitude were undertaken.

  18. Field demonstration of polymer-amended in situ chemical oxidation (PA-ISCO)

    NASA Astrophysics Data System (ADS)

    Silva, Jeff A. K.; Crimi, Michelle; Palaia, Thomas; Ko, Saebom; Davenport, Sean

    2017-04-01

    The methods and results of the first field-scale demonstration of polymer-amended in situ chemical oxidation (PA-ISCO) are presented. The demonstration took place at MCB CAMLEJ (Marine Corps Base, Camp Lejeune) Operable Unit (OU) 15, Site 88, in Camp Lejeune, North Carolina between October and December 2010. PA-ISCO was developed as an alternative treatment approach that utilizes viscosity-modified fluids to improve the in situ delivery and distribution (i.e. sweep-efficiency) of chemical oxidants within texturally heterogeneous contaminated aquifers. The enhanced viscosity of the fluid mitigates the effects of preferential flows, improving sweep-efficiency and enhancing the subsurface contact between the injected oxidant and the target contamination within the treatment zone. The PA-ISCO fluid formulation used in this demonstration included sodium permanganate as oxidant, xanthan gum biopolymer as a shear-thinning viscosifier, and sodium hexametaphosphate (SHMP) as an anti-coagulant. It was the goal of this demonstration to validate the utility of PA-ISCO within a heterogeneous aquifer. An approximate 100% improvement in sweep-efficiency was achieved for the PA-ISCO fluid, as compared to a permanganate-only injection within an adjacent control plot.

  19. The Pittsburgh Sleep Quality Index: validation of the Urdu translation.

    PubMed

    Hashmi, Ali Madeeh; Khawaja, Imran Shuja; Butt, Zeeshan; Umair, Muhammad; Naqvi, Suhaib Haider; Jawad-Ul-Haq

    2014-02-01

    To translate and validate the Pittsburgh Sleep Quality Index (PSQI), a standardized self-administered questionnaire for the assessment of subjective sleep quality into the Urdu language. Validation study. Mayo Hospital, Lahore, from March to April 2012. The PSQI was translated into Urdu following standard guidelines. The final Urdu version (PSQI-U) was administered to 200 healthy volunteers comprising medical students, nursing staff and doctors. Inter-item correlation was assessed by calculating Cronbach alpha. Correlation of component scores with global score was assessed by calculating Spearman correlation coefficient. Correlation between global PSQI-U scores at baseline with global scores for each PSQI-U and PSQI-E at 4-week interval was evaluated by calculating Spearman correlation coefficient. Moreover, scores on individual items of the scale at baseline were compared with respective scores after 4-week by t-test. One hundred and eighty five (185) participants completed the PSQI-U at baseline. The Cronbach alpha for PSQI-U was 0.56. Scores on individual components of the PSQI-U and composite scores were all highly correlated with each other (all p-values < 0.01). Composite scores for PSQI-U at baseline and PSQI-E at 4-week interval were also highly correlated with each other (Spearman correlation coefficient 0.74, p-value < 0.01) indicating good linguistic interchangeability. Composite scores for PSQI-U at baseline and at 4-week interval were positively correlated with each other (Spearman correlation coefficient 0.70, p < 0.01) indicating good test-retest reliability. The PSQI-U is a valid and reliable instrument for the assessment of sleep quality. It shows good linguistic interchangeability and test-retest reliability in comparison to the original English version when applied to individuals who speak the Urdu language. The PSQI-U can be a tool either for clinical management or research.

  20. The Pittsburgh Cervical Cancer Screening Model: a risk assessment tool.

    PubMed

    Austin, R Marshall; Onisko, Agnieszka; Druzdzel, Marek J

    2010-05-01

    Evaluation of cervical cancer screening has grown increasingly complex with the introduction of human papillomavirus (HPV) vaccination and newer screening technologies approved by the US Food and Drug Administration. To create a unique Pittsburgh Cervical Cancer Screening Model (PCCSM) that quantifies risk for histopathologic cervical precancer (cervical intraepithelial neoplasia [CIN] 2, CIN3, and adenocarcinoma in situ) and cervical cancer in an environment predominantly using newer screening technologies. The PCCSM is a dynamic Bayesian network consisting of 19 variables available in the laboratory information system, including patient history data (most recent HPV vaccination data), Papanicolaou test results, high-risk HPV results, procedure data, and histopathologic results. The model's graphic structure was based on the published literature. Results from 375 441 patient records from 2005 through 2008 were used to build and train the model. Additional data from 45 930 patients were used to test the model. The PCCSM compares risk quantitatively over time for histopathologically verifiable CIN2, CIN3, adenocarcinoma in situ, and cervical cancer in screened patients for each current cytology result category and for each HPV result. For each current cytology result, HPV test results affect risk; however, the degree of cytologic abnormality remains the largest positive predictor of risk. Prior history also alters the CIN2, CIN3, adenocarcinoma in situ, and cervical cancer risk for patients with common current cytology and HPV test results. The PCCSM can also generate negative risk projections, estimating the likelihood of the absence of histopathologic CIN2, CIN3, adenocarcinoma in situ, and cervical cancer in screened patients. The PCCSM is a dynamic Bayesian network that computes quantitative cervical disease risk estimates for patients undergoing cervical screening. Continuously updatable with current system data, the PCCSM provides a new tool to monitor

  1. Effect of low frequency ultrasound on combined rt-PA and eptifibatide thrombolysis in human clots.

    PubMed

    Meunier, Jason M; Holland, Christy K; Pancioli, Arthur M; Lindsell, Christopher J; Shaw, George J

    2009-01-01

    Fibrinolytics such as recombinant tissue plasminogen activator (rt-PA) are used to treat thrombotic disease such as acute myocardial infarction (AMI) and ischemic stroke. Interest in increasing efficacy and reducing side effects has led to the study of adjuncts such as GP IIb-IIIa inhibitors and ultrasound (US) enhanced thrombolysis. Currently, GP IIb-IIIa inhibitor and fibrinolytic treatment are often used in AMI, and are under investigation for stroke treatment. However, little is known of the efficacy of combined GP IIb-IIIa inhibitor, fibrinolytic and ultrasound treatment. We measure the lytic efficacy of rt-PA, eptifibatide (Epf) and 120 kHz ultrasound treatment in an in-vitro human clot model. Blood was drawn from 15 subjects after IRB approval. Clots were made in 20 microL pipettes, and placed in a water tank for microscopic visualization during lytic treatment. Clots were exposed to control, rt-PA (rt-PA), eptifibatide (Epf), or rt-PA+eptifibatide (rt-PA + Epf), with (+US) or without (-US) ultrasound for 30 minutes at 37 degrees C in human plasma. Clot lysis was measured over time, using a microscopic imaging technique. The fractional clot loss (FCL) and initial lytic rate (LR) were used to quantify lytic efficacy. LR values for (- US) treated clots were 0.8+/-0.1(control), 1.8+/-0.3 (Epf), 1.5+/-0.2 (rt-PA), and 1.3+/-0.4 (rt-PA + Epf) (% clot width/minute) respectively. In comparison, the (+ US) group exhibited LR values of 1.6+/-0.2 (control), 4.3+/-0.4 (Epf), 6.3+/-0.4 (rt-PA), and 4.6+/-0.6 (rt-PA + Epf). For (- US) treated clots, FCL was 6.0+/-0.8 (control), 9.2+/-2.5 (Epf), 15.6+/-1.7 (rt-PA), and 28.0+/-2.2% (rt-PA + Epf) respectively. FCL for (+ US) clots was 13.5+/-2.4 (control), 20.7+/-6.4 (Epf), 44.4+/-3.6 (rt-PA) and 30.3+/-3.6% (rt-PA + Epf) respectively. Although the addition of eptifibatide enhances the in-vitro lytic efficacy of rt-PA in the absence of ultrasound, the efficacy of ultrasound and rt-PA is greater than that of combined

  2. Adult Stem Cell-Based Enhancement of Nerve Conduit for Peripheral Nerve Repair

    DTIC Science & Technology

    2017-10-01

    INVESTIGATOR:      Rocky  S.  Tuan,  PhD   CONTRACTING  ORGANIZATION:  University  of  Pittsburgh Pittsburgh, PA 15213   REPORT  DATE:   October 2017...TYPE  OF   REPORT :      Annual   PREPARED  FOR:      U.S.  Army  Medical  Research  and  Materiel  Command    Fort  Detrick,  Maryland    21702...this   report  are  those  of  the  author(s)  and  should  not  be   construed  as  an  official  Department  of  the  Army  position,  policy  or

  3. Temperature affects thrombolytic efficacy using rt-PA and eptifibatide, an in vitro study.

    PubMed

    Meunier, Jason M; Chang, Wan-Tsu W; Bluett, Brent; Wenker, Evan; Lindsell, Christopher J; Shaw, George J

    2012-09-01

    The potential for hypothermia as a neuroprotectant during stroke has led to its increase in clinical use. At the same time, combination pharmaceutical therapies for ischemic stroke using recombinant tissue plasminogen activator (rt-PA), and GP IIb-IIIa inhibitors, such as Eptifibatide (Epf ), are under study. However, there is little data on how the reactions triggered by these agents are impacted by temperature. Here, clot lysis during exposure to the combination of rt-PA and Epf is measured in an in vitro human clot model at hypothermic temperatures. The hypothesis is that lytic efficacy of rt-PA and Epf decreases with decreasing temperature. Whole blood clots from 31 volunteers were exposed to rt-PA (0.5 μg/mL) and Epf (0.63 μg/mL) in human fresh-frozen plasma (rt-PA+Epf ), rt-PA alone in plasma (rt-PA Alone), or to plasma alone (Control), at temperatures from 30°C to 37°C, for 30 minutes. Clot lysis was measured using a microscopic imaging technique; the mean fractional clot loss (FCL) at 30 minutes was used to determine lytic efficacy. Temperature had a significant impact on FCL in clots exposed to rt-PA+Epf, with the FCL being lower at 30°C to 36°C than at 37°C. The FCL remained significantly higher for rt-PA+Epf–treated clots than Controls regardless of temperature, with the exception of measurements made at 30°C when no significant differences in the FCL were observed between groups. The use of hypothermia as a neuroprotectant may negatively impact the therapeutic benefit of thrombolytic agents.

  4. Temperature Affects Thrombolytic Efficacy Using rt-PA and Eptifibatide, an In Vitro Study

    PubMed Central

    Chang, Wan-Tsu W.; Bluett, Brent; Wenker, Evan; Lindsell, Christopher J.; Shaw, George J.

    2012-01-01

    The potential for hypothermia as a neuroprotectant during stroke has led to its increase in clinical use. At the same time, combination pharmaceutical therapies for ischemic stroke using recombinant tissue plasminogen activator (rt-PA), and GP IIb-IIIa inhibitors, such as Eptifibatide (Epf ), are under study. However, there is little data on how the reactions triggered by these agents are impacted by temperature. Here, clot lysis during exposure to the combination of rt-PA and Epf is measured in an in vitro human clot model at hypothermic temperatures. The hypothesis is that lytic efficacy of rt-PA and Epf decreases with decreasing temperature. Whole blood clots from 31 volunteers were exposed to rt-PA (0.5 μg/mL) and Epf (0.63 μg/mL) in human fresh-frozen plasma (rt-PA+Epf ), rt-PA alone in plasma (rt-PA Alone), or to plasma alone (Control), at temperatures from 30°C to 37°C, for 30 minutes. Clot lysis was measured using a microscopic imaging technique; the mean fractional clot loss (FCL) at 30 minutes was used to determine lytic efficacy. Temperature had a significant impact on FCL in clots exposed to rt-PA+Epf, with the FCL being lower at 30°C to 36°C than at 37°C. The FCL remained significantly higher for rt-PA+Epf–treated clots than Controls regardless of temperature, with the exception of measurements made at 30°C when no significant differences in the FCL were observed between groups. The use of hypothermia as a neuroprotectant may negatively impact the therapeutic benefit of thrombolytic agents. PMID:23667777

  5. Regular Practice of Competitive Sports Does Not Impair Sleep in Adolescents: DADOS Study.

    PubMed

    Beltran-Valls, María Reyes; García Artero, Enrique; Capdevila-Seder, Ana; Legaz-Arrese, Alejandro; Adelantado-Renau, Mireia; Moliner-Urdiales, Diego

    2018-05-01

    To analyze differences in sleep quality and duration by athletic status and sex, and to examine the association between physical activity (PA) recommendation and sleep in adolescents. A total of 267 adolescents [13.9 (0.3) y] from Deporte, ADOlescencia y Salud (DADOS) study (129 girls) were included in this cross-sectional analysis. Athletes competed regularly in organized sport events and trained ≥3 days per week, but nonathletes did not compete. PA was assessed by GENEActiv accelerometer. PA values were dichotomized into inactive (<60 min/d of moderate and vigorous PA) and active (≥60 min/d of moderate and vigorous PA). Sleep quality was evaluated with the Spanish version of the Pittsburgh Sleep Quality Index. Pittsburgh Sleep Quality Index values were dichotomized into >5 (poor quality) or ≤5 (good quality). Sleep duration was objectively measured by accelerometer. Sleep quality and duration were not statistically different between athletes [median (Mdn) = 4.0, interquartile range (IQR) = 3.0-6.0 and Mdn = 8.0, IQR = 7.4-8.6 h, respectively] and nonathletes (Mdn = 5.0, IQR = 3.0-7.0 and Mdn = 7.9; IQR = 7.3-8.6 h, respectively), P > .05. Nonathlete or inactive adolescents did not show higher risk for poor sleep quality or short sleep duration than athletes [odds ratio (OR) = 1.17; 95% confidence interval (CI), 0.68-2.00 and OR = 0.93; 95% CI, 0.56-1.55, respectively] or active peers (OR = 1.39; 95% CI, 0.66-2.89 and OR = 1.62; 95% CI, 0.78-3.37, respectively). In our group of adolescents, competitive sport practice did not alter sleep patterns. PA recommendations for adolescents may not discriminate between good and poor sleepers.

  6. Barriers and Motives to PA in South Asian Indian Immigrant Women.

    PubMed

    Daniel, Manju; Abendroth, Maryann; Erlen, Judith A

    2017-03-01

    The high prevalence of chronic illnesses in South Asian Indian immigrant women underscores the need for identifying factors that could influence their PA. The purpose of this qualitative study was to examine the perspectives of South Asian Indian immigrant women related to barriers to and motives for lifestyle PA within the PA Framework for South Asian Indian Immigrants. Forty women participated in focus groups that were conducted in English and Hindi. Focus group questions were open-ended and semistructured. Transcribed and de-identified audiotaped sessions were coded and analyzed using Atlas.ti software. Role expectation was a core theme for barriers with four subthemes: lack of time, loss of interest, diminished social support, and environmental constraints. Self-motivation was a core theme for motives with three subthemes: optimal physical and psychological health, emphasis on external beauty, and strong social support. Future PA interventions need to target these culturally sensitive factors.

  7. A novel plasminogen activator from Agkistrodon blomhoffii Ussurensis venom (ABUSV-PA): Purification and characterization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu Shuqing; Sun Mingzhong; Greenaway, Frederick T.

    2006-10-06

    A plasminogen activator with arginine ester hydrolysis activity (ABUSV-PA) has been identified and purified to homogeneity from Chinese Agkistrodon blomhoffii Ussurensis snake venom. ABUSV-PA, a monomeric protein with molecular mass of 27815.2 Da, was purified 180-fold with 0.02% recovery for protein and 3.6% recovery for esterase activity. ABUSV-PA reacts optimally with its substrate N {sub {alpha}}-tosyl-L-arginine-methyl ester (TAME) at {approx}pH 7.5 and at 51 {sup o}C. Measurement from inductively coupled plasma-atomic emission spectroscopy (ICP-AES) reveals that ABUSV-PA is a Zn{sup 2+}-containing protein with a stoichiometry of 1:1 [Zn{sup 2+}]:[ABUSV-PA]. Analyses of esterase hydrolysis and UV absorption and CD spectra indicatemore » that Zn{sup 2+} plays an important role in maintaining the structural integrity rather than the esterase activity of ABUSV-PA. Divalent metal ions, including Ca{sup 2+}, Mg{sup 2+}, Cu{sup 2+}, Ni{sup 2+}, Mn{sup 2+}, and Co{sup 2+}, increase the TAME hydrolysis activity of ABUSV-PA. A red-shift of the emission wavelengths of the synchronous fluorescence of ABUSV-PA, compared to those of free Tyr and Trp, indicates a conformation where the Tyr and Trp residues are in exposed hydrophilic environments. The presence of zinc increases the hydrophobicity of the conformational environments surrounding the Trp residues of ABUSV-PA and affects the secondary structure of ABUSV-PA, as proved by UV absorption and CD spectroscopy.« less

  8. Effect of Low Frequency Ultrasound on Combined rt-PA and Eptifibatide Thrombolysis in Human Clots

    PubMed Central

    Meunier, Jason M.; Holland, Christy K.; Pancioli, Arthur M.; Lindsell, Christopher J.; Shaw, George J.

    2009-01-01

    Introduction Fibrinolytics such as recombinant tissue plasminogen activator (rt-PA) are used to treat thrombotic disease such as acute myocardial infarction (AMI) and ischemic stroke. Interest in increasing efficacy and reducing side effects has led to the study of adjuncts such as GP IIb-IIIa inhibitors and ultrasound (US) enhanced thrombolysis. Currently, GP IIb-IIIa inhibitor and fibrinolytic treatment are often used in AMI, and are under investigation for stroke treatment. However, little is known of the efficacy of combined GP IIb-IIIa inhibitor, fibrinolytic and ultrasound treatment. We measure the lytic efficacy of rt-PA, eptifibatide (Epf) and 120 kHz ultrasound treatment in an in-vitro human clot model. Materials and Methods Blood was drawn from 15 subjects after IRB approval. Clots were made in 20 μL pipettes, and placed in a water tank for microscopic visualization during lytic treatment. Clots were exposed to control, rt-PA (rt-PA), eptifibatide (Epf), or rt-PA+eptifibatide (rt-PA+Epf), with or without ultrasound for 30 minutes at 37°C in human plasma. Clot lysis was measured over time, using a microscopic imaging technique. The fractional clot loss (FCL) and initial lytic rate (LR) were used to quantify lytic efficacy. Results and Conclusions LR values for (−US) treated clots were 0.8±0.1(control), 1.8±0.3 (Epf), 1.5±0.2 (rt-PA), and 1.3±0.4 (rt-PA+Epf) (% clot width/minute) respectively. In comparison, the (+US) group exhibited LR values of 1.6±0.2 (control), 4.3±0.4 (Epf), 6.3±0.4 (rt-PA), and 4.6±0.6 (rt-PA+Epf). For (−US) treated clots, FCL was 6.0±0.8 (control), 9.2±2.5 (Epf), 15.6±1.7 (rt-PA), and 28.0±2.2% (rt-PA+Epf) respectively. FCL for (+US) clots was 13.5±2.4 (control), 20.7±6.4 (Epf), 44.4±3.6 (rt-PA) and 30.3±3.6% (rt-PA+Epf) respectively. Although the addition of eptifibatide enhances the in-vitro lytic efficacy of rt-PA in the absence of ultrasound, the efficacy of ultrasound and rt-PA is greater than that of

  9. 47 CFR 90.311 - Frequencies.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MOBILE RADIO SERVICES Authorization in the Band 470-512 MHz (UHF-TV Sharing) § 90.311 Frequencies. (a.... NJ Pittsburgh, PA 470.30625 to 472.99375 473.30625 to 475.99375 Los Angeles, CA 470.05625 to 472....99375 479.30625 to 481.99375 16 Boston, MADallas/Fort Worth, TX Detroit, MI San Francisco/Oakland, CA...

  10. 47 CFR 90.311 - Frequencies.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... MOBILE RADIO SERVICES Authorization in the Band 470-512 MHz (UHF-TV Sharing) § 90.311 Frequencies. (a.... NJ Pittsburgh, PA 470.30625 to 472.99375 473.30625 to 475.99375 Los Angeles, CA 470.05625 to 472....99375 479.30625 to 481.99375 16 Boston, MADallas/Fort Worth, TX Detroit, MI San Francisco/Oakland, CA...

  11. Complexity and Safety (FAA)

    DTIC Science & Technology

    2016-10-27

    Software Engineering Institute Carnegie Mellon University Pittsburgh, PA 15213 © 2016 Carnegie Mellon University [DISTRIBUTION STATEMENT A: This... Carnegie Mellon University [DISTRIBUTION STATEMENT A: This material has been approved for public release and unlimited distribution] Copyright 2016 Carnegie ... Carnegie Mellon University for the operation of the Software Engineering Institute, a federally funded research and development center sponsored by

  12. Interleaving Semantic Web Reasoning and Service Discovery to Enforce Context-Sensitive Security and Privacy Policies

    DTIC Science & Technology

    2005-07-01

    policies in pervasive computing environments. In this context, the owner of information sources (e.g. user, sensor, application, or organization...work in decentralized trust management and semantic web technologies . Section 3 introduces an Information Disclosure Agent architecture for...Norman Sadeh July 2005 CMU-ISRI-05-113 School of Computer Science, Carnegie Mellon University 5000 Forbes Avenue, Pittsburgh, PA, 15213

  13. US Army Research Laboratory (ARL) Robotics Collaborative Technology Alliance 2014 Capstone Experiment

    DTIC Science & Technology

    2016-07-01

    ARL-TR-7729 ● JULY 2016 US Army Research Laboratory US Army Research Laboratory (ARL) Robotics Collaborative Technology Alliance...TR-7729 ● JULY 2016 US Army Research Laboratory US Army Research Laboratory (ARL) Robotics Collaborative Technology Alliance 2014 Capstone...National Robotics Engineering Center, Pittsburgh, PA Robert Dean, Terence Keegan, and Chip Diberardino General Dynamics Land Systems, Westminster

  14. Private I: The Protagonists in Lynne Rae Perkins' Newbery-Winning Novel Are Shy, Talented, and Extremely Thoughtful--Kind of Like the Author

    ERIC Educational Resources Information Center

    Barstow, Barb

    2006-01-01

    Lynne Rae Perkins is the author of "Criss Cross," which won the Newbery Medal, the nation's most prestigious prize for children's book. Perkins grew up in Cheswick, PA, near Pittsburgh, majored in printmaking at Penn State, and attended grad school at the University of Wisconsin-Milwaukee. She moved to Leelanau County, MI, in 1987 with her…

  15. Spare a Little Change? Towards a 5-Nines Internet in 250 Lines of Code

    DTIC Science & Technology

    2011-05-01

    NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Carnegie Mellon University,School of Computer Science,Pittsburgh,PA,15213 8. PERFORMING ...Std Z39-18 Keywords: Internet reliability, BGP performance , Quagga This document includes excerpts of the source code for the Linux operating system...Behavior and Performance . . . . . . . . . . . . . . . . . . . . . . . . . . .  .. Other Related Work

  16. Adaptive Model-Predictive Motion Planning for Navigation in Complex Environments

    DTIC Science & Technology

    2009-08-01

    AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Carnegie Mellon University,The...Robotics Institute,Pittsburgh,PA,15213 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR...6 1.5 Assumptions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 1.6 Organization

  17. Complexity, Systems, and Software

    DTIC Science & Technology

    2014-08-14

    2014 Carnegie Mellon University Complexity, Systems, and Software Software Engineering Institute Carnegie Mellon University Pittsburgh, PA...this collection of information, including suggestions for reducing this burden, to Washington Headquarters Services , Directorate for Information...OMB control number. 1. REPORT DATE 29 OCT 2014 2. REPORT TYPE N/A 3. DATES COVERED 4. TITLE AND SUBTITLE Complexity, Systems, and Software

  18. 76 FR 5647 - Pennsylvania Disaster #PA-00036

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-01

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12449 and 12450] Pennsylvania Disaster PA... Administrative declaration of a disaster for the Commonwealth of Pennsylvania dated 01/25/2011. Incident... the disaster: Primary Counties: Philadelphia. Contiguous Counties: Pennsylvania: Bucks, Delaware...

  19. RadNet Air Data From Philadelphia, PA

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Philadelphia, PA from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  20. 75 FR 71486 - Pennsylvania Disaster # PA-00035

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-23

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12389 and 12390] Pennsylvania Disaster PA... Administrative declaration of a disaster for the Commonwealth of Pennsylvania dated 11/15/2010. Incident: Severe... the disaster: Primary Counties: Delaware. Contiguous Counties: Pennsylvania: Chester, Montgomery...

  1. RadNet Air Data From Bloomsburg, PA

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Bloomsburg, PA from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  2. 23 CFR Appendix F to Part 1200 - Planning and Administration (P&A) Costs

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Planning and Administration (P&A) Costs F Appendix F to... HIGHWAY SAFETY GRANT PROGRAMS Pt. 1200, App. F Appendix F to Part 1200—Planning and Administration (P&A) Costs (a) Policy. Federal participation in P&A activities shall not exceed 50 percent of the total cost...

  3. 23 CFR Appendix F to Part 1200 - PLANNING AND ADMINISTRATION (P&A) COSTS

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false PLANNING AND ADMINISTRATION (P&A) COSTS F APPENDIX F TO... HIGHWAY SAFETY GRANT PROGRAMS Pt. 1200, App. F APPENDIX F TO PART 1200—PLANNING AND ADMINISTRATION (P&A) COSTS (a) Policy. Federal participation in P&A activities shall not exceed 50 percent of the total cost...

  4. PaLaCe: A Coarse-Grain Protein Model for Studying Mechanical Properties.

    PubMed

    Pasi, Marco; Lavery, Richard; Ceres, Nicoletta

    2013-01-08

    We present a coarse-grain protein model PaLaCe (Pasi-Lavery-Ceres) that has been developed principally to allow fast computational studies of protein mechanics and to clarify the links between mechanics and function. PaLaCe uses a two-tier protein representation with one to three pseudoatoms representing each amino acid for the main nonbonded interactions, combined with atomic-scale peptide groups and some side chain atoms to allow the explicit representation of backbone hydrogen bonds and to simplify the treatment of bonded interactions. The PaLaCe force field is composed of physics-based terms, parametrized using Boltzmann inversion of conformational probability distributions derived from a protein structure data set, and iteratively refined to reproduce the experimental distributions. PaLaCe has been implemented in the MMTK simulation package and can be used for energy minimization, normal mode calculations, and molecular or stochastic dynamics. We present simulations with PaLaCe that test its ability to maintain stable structures for folded proteins, reproduce their dynamic fluctuations, and correctly model large-scale, force-induced conformational changes.

  5. 78 FR 49270 - Information Collection; MyUSA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-13

    ... Floor, Washington, DC 20405- 0001. ATTN: Hada Flowers/IC 3090-00XX; MyUSA. Instructions: Please submit...-4755. ATTN: Hada Flowers/ IC 3090-00xx; MyUSA. Please cite OMB Control No. 3090-XXXX; MyUSA, in all...

  6. Design and implementation of a library-based information service in molecular biology and genetics at the University of Pittsburgh

    PubMed Central

    Chattopadhyay, Ansuman; Tannery, Nancy Hrinya; Silverman, Deborah A. L.; Bergen, Phillip; Epstein, Barbara A.

    2006-01-01

    Setting: In summer 2002, the Health Sciences Library System (HSLS) at the University of Pittsburgh initiated an information service in molecular biology and genetics to assist researchers with identifying and utilizing bioinformatics tools. Program Components: This novel information service comprises hands-on training workshops and consultation on the use of bioinformatics tools. The HSLS also provides an electronic portal and networked access to public and commercial molecular biology databases and software packages. Evaluation Mechanisms: Researcher feedback gathered during the first three years of workshops and individual consultation indicate that the information service is meeting user needs. Next Steps/Future Directions: The service's workshop offerings will expand to include emerging bioinformatics topics. A frequently asked questions database is also being developed to reuse advice on complex bioinformatics questions. PMID:16888665

  7. 75 FR 2165 - Pennsylvania Disaster #PA-00030

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-14

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12002 and 12003] Pennsylvania Disaster PA... Administrative declaration of a disaster for the Commonwealth of Pennsylvania dated 01/07/2010. Incident... adversely affected by the disaster: Primary Counties: Centre. Contiguous Counties: Pennsylvania: Blair...

  8. 77 FR 60004 - Pennsylvania Disaster #PA-00053

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13307 and 13308] Pennsylvania Disaster PA... Administrative declaration of a disaster for the Commonwealth of Pennsylvania dated 09/21/2012. Incident... adversely affected by the disaster: Primary Counties: Centre. Contiguous Counties: Pennsylvania: Blair...

  9. Binding of anti-SSA antibodies to apoptotic fetal cardiocytes stimulates urokinase plasminogen activator (uPA)/uPA receptor-dependent activation of TGF-β and potentiates fibrosis.

    PubMed

    Briassouli, Paraskevi; Rifkin, Daniel; Clancy, Robert M; Buyon, Jill P

    2011-11-15

    In congenital heart block (CHB), binding of maternal anti-SSA/Ro Abs to fetal apoptotic cardiocytes impairs their removal by healthy cardiocytes and increases urokinase plasminogen activator (uPA)/uPA receptor (uPAR)-dependent plasmin activation. Because the uPA/uPAR system plays a role in TGF-β activation, we evaluated whether anti-Ro binding to apoptotic cardiocytes enhances plasmin-mediated activation of TGF-β, thereby promoting a profibrosing phenotype. Supernatants from cocultures of healthy cardiocytes and apoptotic cardiocytes bound by IgG from a mother whose child had CHB (apoptotic-CHB-IgG [apo-CHB-IgG]) exhibited significantly increased levels of active TGF-β compared with supernatants from cocultures of healthy cardiocytes and apoptotic cardiocytes preincubated with IgG from a healthy donor. Treatment of the culture medium with anti-TGF-β Ab or TGF-β inhibitor (SB431542) abrogated the luciferase response, thereby confirming TGF-β dependency. Increased uPA levels and activity were present in supernatants generated from cocultures of healthy cardiocytes and apo-CHB-IgG cardiocytes compared with healthy cardiocytes and apoptotic cardiocytes preincubated with IgG from a healthy donor, respectively. Treatment of apo-CHB-IgG cardiocytes with anti-uPAR or anti-uPA Abs or plasmin inhibitor aprotinin prior to coculturing with healthy cardiocytes attenuated TGF-β activation. Supernatants derived from cocultures of healthy cardiocytes and apo-CHB-IgG cardiocytes promoted Smad2 phosphorylation and fibroblast transdifferentiation, as evidenced by increased smooth muscle actin and collagen expression, which decreased when fibroblasts were treated with supernatants from cocultures pretreated with uPAR Abs. These data suggested that binding of anti-Ro Abs to apoptotic cardiocytes triggers TGF-β activation, by virtue of increasing uPAR-dependent uPA activity, thus initiating and amplifying a cascade of events that promotes myofibroblast transdifferentiation and

  10. Infrared Spectroscopy of Pa-beta and [Fe II] Emission in NGC 4151

    NASA Technical Reports Server (NTRS)

    Knop, R. A.; Armus, L.; Larkin, J. E.; Matthews, K.; Shupe, D. L.; Soifer, B. T.

    1996-01-01

    We present spatially resolved 1.24-1.30 micron spectroscopy with a resolution of 240 km/s of the Seyfert 1.5 galaxy NGC 4151. Broad Pa-beta, narrow Pa-beta, and narrow [Fe II] (lambda = 1.2567 micron) emission lines are identified in the spectrum. Additionally, a spatially unresolved narrow component probably due to [S ix] (lambda = 1.25235 micron) is observed on the nucleus. The narrow Pa-beta and [Fe II] lines are observed to be extended over a scale of 5 sec. The spatial variation of the velocity centers of the Pa-beta and [Fe II] lines show remarkable similarity, and additionally show similarities to the velocity structure previously observed in ground based spectroscopy of [O III] emission in NGC 4151. This leads to the conclusion that the [Fe II] emission arises in clouds in the Seyfert narrow line region that are physically correlated with those narrow line clouds responsible for the optical emission. The [Fe II] emission line, however, is significantly wider than the Pa-beta emission line along the full spatial extent of the observed emission. This result suggests that despite the correlation between the bulk kinematics of Pa-beta and [Fe II], there is an additional process, perhaps fast shocks from a wind in the Seyfert nucleus, contributing to the [Fe II] emission.

  11. PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release

    PubMed Central

    Singh, Ramandeep; Manjunatha, Ujjini; Boshoff, Helena I. M.; Ha, Young Hwan; Niyomrattanakit, Pornwaratt; Ledwidge, Richard; Dowd, Cynthia S.; Lee, Ill Young; Kim, Pilho; Zhang, Liang; Kang, Sunhee; Keller, Thomas H.; Jiricek, Jan; Barry, Clifton E.

    2009-01-01

    Bicyclic nitroimidazoles, including PA-824, are exciting candidates for the treatment of tuberculosis. These prodrugs require intracellular activation for their biological function. We found that Rv3547 is a deazaflavin-dependent nitroreductase (Ddn) that converts PA-824 into three primary metabolites; the major one is the corresponding des-nitroimidazole (des-nitro). When derivatives of PA-824 were used, the amount of des-nitro metabolite formed was highly correlated with anaerobic killing of Mycobacterium tuberculosis (Mtb). Des-nitro metabolite formation generated reactive nitrogen species, including nitric oxide (NO), which are the major effectors of the anaerobic activity of these compounds. Furthermore, NO scavengers protected the bacilli from the lethal effects of the drug. Thus, these compounds may act as intracellular NO donors and could augment a killing mechanism intrinsic to the innate immune system. PMID:19039139

  12. Identifying a susceptible subgroup: effects of the Pittsburgh air pollution episode upon schoolchildren.

    PubMed

    Stebbings, J H; Fogleman, D G

    1979-07-01

    Pulmonary function test results on 224 parochial schoolchildren collected during and after the Pittsburgh air pollution episode of November 1975 were reanalyzed to determine whether a small subgroup of susceptible children could be defined. Individual regressions of three-quarter second forced expiratory volumes (FEV.75) and forced vital capacities (FVC) on time over the six-day study period were calculated, and the distributions of individual slopes for the four exposed and two control schools were compared. Excesses of strong upward trends in the exposed areas would suggest effects of suspended particulate air pollution by indicating significant improvement following the episode. A highly statistically significant excess of strong upward trends in the FVC among exposed students was observed, and was consistent by sex and by school within sex. Approximately 10--15% of the students appear susceptible to an average impairment of about 20% of the FVC. The findings are limited by the small number of subjects with strong post-episode upward trends in the FVC, and by lack of validation by replication of the study design, but do suggest that episode levels of suspended particulates induce lung damage, and that this may occur only in a small susceptible subgroup. Children with low baseline pulmonary function values, histories of asthma, or with acute respiratory symptoms immediately following the episode were not found to be especially susceptible to these effects of suspended particulates.

  13. 76 FR 58328 - Pennsylvania Disaster #PA-00042

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12820 and 12821] Pennsylvania Disaster PA... Presidential declaration of a major disaster for the Commonwealth of Pennsylvania (FEMA-4025-DR), dated 09/ 12..., Philadelphia, Sullivan, Wyoming. Contiguous Counties (Economic Injury Loans Only): Pennsylvania: Berks...

  14. 78 FR 52600 - Pennsylvania Disaster #PA-00063

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13722 and 13723] Pennsylvania Disaster PA... Administrative declaration of a disaster for the Commonwealth of Pennsylvania dated 08/14/2013. Incident: Severe... adversely affected by the disaster: Primary Counties: Lawrence. Contiguous Counties: Pennsylvania: Beaver...

  15. 78 FR 45282 - Pennsylvania Disaster #PA-00058

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-26

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13669 and 13670] Pennsylvania Disaster PA... Administrative declaration of a disaster for the Commonwealth of Pennsylvania dated 07/16/2013. Incident: Severe...: Pennsylvania: Armstrong; Blair; Cambria; Cameron; Centre; Clarion; Clinton; Elk; Forest; Greene; Indiana...

  16. “Food is directed to the area”: African Americans’ perceptions of the neighborhood nutrition environment in Pittsburgh

    PubMed Central

    Quinn, Sandra C.; Kriska, Andrea M.; Thomas, Stephen B.

    2011-01-01

    Studies have shown racial disparities in neighborhood access to healthy food in the United States. We used a mixed methods approach employing geographic information systems, focus groups, and a survey to examine African Americans’ perceptions of the neighborhood nutrition environment in Pittsburgh. We found that African Americans perceive that supermarkets serving their community offer produce and meats of poorer quality than branches of the same supermarket serving White neighborhoods (p<0.001). Unofficial taxis or jitneys, on which many African Americans are reliant, provide access from only certain stores; people are therefore forced to patronize these stores even though they are perceived to be of poorer quality. Community-generated ideas to tackle the situation include ongoing monitoring of supermarkets serving the Black community. We conclude that stores should make every effort to be responsive to the perceptions and needs of their clients and provide an environment that enables healthy eating. PMID:21169050

  17. The t-PA-encapsulated PLGA nanoparticles shelled with CS or CS-GRGD alter both permeation through and dissolving patterns of blood clots compared with t-PA solution: an in vitro thrombolysis study.

    PubMed

    Wang, Shoei-Shen; Chou, Nai-Kuan; Chung, Tze-Wen

    2009-12-01

    Accelerated thrombolysis by pressure-driven permeation has been demonstrated in in vitro and in vivo animal models by using plasminogen activators (PAs) encapsulated liposomes or PEG microparticles. Recent reports have also described acceleration of thrombolysis using tissue type PA (t-PA) encapsulated in PLGA nanoparticles (NPs) coated with chitosan (CS) or CS-GRGD by interactions between the NPs and blood clots. However, the permeation through and dissolving patterns in thrombolysis with the aforementioned microparticles or NPs, which may be clinically relevant to the recovery status of the posttreatments, have not been reported. Therefore, this work studied such phenomena in thrombolysis with t-PA encapsulated in NPs. The t-PA solution and the NPs exhibited distinctly different permeation patterns of dissolved clots. Plasma permeates through clots showed a stream flow or burst flow phenomena when lyzed with NPs shelled with CS or CS-GRGD, respectively, whereas a diffusion pattern was observed in those lyzed with t-PA solution. At the outlet position of clots, the clots dissolved with PLGA/CS and PLGA/CS-GRGD NPs revealed extremely rough surfaces to a depth of 100 mum, indicating that a cross-permeation direction of clot lysis occurred, while those dissolved with t-PA solution showed slightly rough surfaces to a depth of 12 mum. Permeation through and clot dissolution patterns of thrombolysis with t-PA encapsulated in NPs shelled with CS or CS-GRGD distinctly differed from those dissolved with t-PA solutions in this in vitro thrombolysis model, These findings may be relevant to posttreatment of patients with conventional PA thrombolysis. Copyright 2008 Wiley Periodicals, Inc.

  18. Metastasis Research Society VII International Congress (Part II). 7-10 October 1998, San Diego, CA, USA.

    PubMed

    Chambers, A F

    1999-02-01

    The Metastasis Research Society (MRS) has held its International Congress every two years since 1986, and alternates between European and North American meeting venues. The next MRS International Congress will be held in London, UK in the year 2000, and will be hosted by the current MRS President, Dr. Suzanne Eccles (Institute of Cancer Research, Sutton, UK). Dr. Eccles took over from the out-going President, Dr. William Stetler-Stevenson (National Institutes of Health, Bethesda, MD, USA), at the San Diego meeting. Information on joining the Metastasis Research Society, which includes a subscription to the Society's journal, Clinical and Experimental Metastasis, can be obtained from Dr. Eccles (suzan@icr.ac.uk) or from the newly-elected Secretary/Treasurer Dr. Danny Welch (Hershey, PA, USA; drw9@psu.edu). The meeting was organized by Darwin Medical Communications Ltd (Gill Heaton, Oxford, UK), who have placed the full program on the meeting web site (http:@www.sparks.co.uk/mrs). It is envisaged that full abstracts of all the presentations will be placed on the Metastasis Research Society web site, which is currently under construction. Corporate sponsors for the San Diego meeting included Agouron Pharmaceuticals, Becton Dickinson & Co, Zeneca Pharma SA, Schering AG, AntiCancer Inc, Oncogene Research Products, Daiichi Seiyaku Co Ltd and Novartis Pharma AG.

  19. 32 CFR 701.113 - PA exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.113 PA exemptions. (a) Exempt systems of records. 5... records that is filed in a non-exempt system of records retains its exempt status. (e) Types of exemptions.... They are: (i) “(k)(1)”: Information which is properly classified under E.O. in the interest of national...

  20. 76 FR 53964 - Dale J. Bingham, P.A.; Revocation of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Dale J. Bingham, P.A.; Revocation of... Enforcement Administration, issued an Order to Show Cause to Dale J. Bingham, P.A. (Registrant), of Ash Fork... 28 CFR 0.100(b), I order that DEA Certificate of Registration MB1048746, issued to Dale J. Bingham, P...

  1. 76 FR 39038 - Proposed Establishment of Class E Airspace; Lebanon, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-05

    ...-0558; Airspace Docket No. 11-AEA-13] Proposed Establishment of Class E Airspace; Lebanon, PA AGENCY... action proposes to establish Class E Airspace at Lebanon, PA, to accommodate new Standard Instrument... amendment to Title 14, Code of Federal Regulations (14 CFR) part 71 to establish Class E airspace at Lebanon...

  2. 78 FR 47814 - Pennsylvania Disaster # PA-00059

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-06

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13676 and 13677] Pennsylvania Disaster PA-00059 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an...: 04/29/2014. ADDRESSES: Submit completed loan applications to: U.S. Small Business Administration...

  3. 76 FR 58327 - Pennsylvania Disaster #PA-00044

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12822 and 12823] Pennsylvania Disaster PA... Presidential declaration of a major disaster for the Commonwealth of Pennsylvania (FEMA-4030-DR), dated 09/ 12.... Contiguous Counties (Economic Injury Loans Only): Pennsylvania: Berks, Carbon, Centre, Chester, Clinton...

  4. Crystal structure of an avian influenza polymerase PA[subscript N] reveals an endonuclease active site

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yuan, Puwei; Bartlam, Mark; Lou, Zhiyong

    2009-11-10

    The heterotrimeric influenza virus polymerase, containing the PA, PB1 and PB2 proteins, catalyses viral RNA replication and transcription in the nucleus of infected cells. PB1 holds the polymerase active site and reportedly harbours endonuclease activity, whereas PB2 is responsible for cap binding. The PA amino terminus is understood to be the major functional part of the PA protein and has been implicated in several roles, including endonuclease and protease activities as well as viral RNA/complementary RNA promoter binding. Here we report the 2.2 angstrom (A) crystal structure of the N-terminal 197 residues of PA, termed PA(N), from an avian influenzamore » H5N1 virus. The PA(N) structure has an alpha/beta architecture and reveals a bound magnesium ion coordinated by a motif similar to the (P)DX(N)(D/E)XK motif characteristic of many endonucleases. Structural comparisons and mutagenesis analysis of the motif identified in PA(N) provide further evidence that PA(N) holds an endonuclease active site. Furthermore, functional analysis with in vivo ribonucleoprotein reconstitution and direct in vitro endonuclease assays strongly suggest that PA(N) holds the endonuclease active site and has critical roles in endonuclease activity of the influenza virus polymerase, rather than PB1. The high conservation of this endonuclease active site among influenza strains indicates that PA(N) is an important target for the design of new anti-influenza therapeutics.« less

  5. Walk-through survey report, Dravo Corporation, Engineering Works Ddivision, Neville Island, Pittsburgh, Pennsylvania, January 30, 1979

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Billings, C.; Lazar, C.

    1980-06-01

    A walk-through survey was conducted on January 30, 1979, at the Engineering Works Division Shipyard of the Dravo Corporation in Pittsburgh, Pennsylvania, to determine whether this site would be suitable for inclusion in the in-depth survey of the shipbuilding-industry segment of the investigation of health hazards to painters. The shipyard is engaged in the design and construction of barges and towboats for river transport of bulk cargoes. Out of a workforce of 1,200 production personnel, there are 10 spray painters, 13 brush painters, 3 sign painters, and 10 painters' assistants. The painters have a low turnover rate and the companymore » has personnel records dating back to World War I. A safety and industrial-hygiene program operates at the facility and requires respiratory usage and various engineering controls for many painting operations. The authors conclude that the facility needs a better industrial-hygiene program than is now in effect. They recommend that the facility be included for consideration in the final study.« less

  6. 78 FR 4967 - Pennsylvania Disaster #PA-00057

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-23

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13463 and 13464] Pennsylvania Disaster PA-00057 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Pennsylvania (FEMA...

  7. 76 FR 44646 - Pennsylvania Disaster #PA-00040

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-26

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12697 and 12698] Pennsylvania Disaster PA-00040 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the Commonwealth of Pennsylvania...

  8. 76 FR 64419 - Pennsylvania Disaster #PA-00045

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12879 and 12880] Pennsylvania Disaster PA-00045 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the Commonwealth of Pennsylvania...

  9. 78 FR 60366 - Pennsylvania Disaster #PA-00064

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-01

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13777 and 13778] Pennsylvania Disaster PA-00064 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Pennsylvania dated 09/24/2013. Incident: Storms...

  10. How to catch a parasite: Parasite Niche Modeler (PaNic) meets Fishbase

    USGS Publications Warehouse

    Strona, Giovanni; Lafferty, Kevin D.

    2012-01-01

    Parasite Niche Modeler (PaNic) is a free online software tool that suggests potential hosts for fish parasites. For a particular parasite species from the major helminth groups (Acanthocephala, Cestoda, Monogenea, Nematoda, Trematoda), PaNic takes data from known hosts (maximum body length, growth rate, life span, age at first maturity, trophic level, phylogeny, and biogeography) and hypothesizes similar fish species that might serve as hosts to that parasite. Users can give varying weights to host attributes and create custom models. In addition to suggesting plausible hosts (with varying degrees of confidence), the models indicate known host species that appear to be outliers in comparison to other known hosts. These unique features make PaNic an innovative tool for addressing both theoretical and applied questions in fish parasitology. PaNic can be accessed at .

  11. Final report on key comparison APMP.M.P-K3: Absolute pressure measurements in gas from 3 × 10-6 Pa to 9 × 10-4 Pa

    NASA Astrophysics Data System (ADS)

    Yoshida, H.; Arai, K.; Akimichi, H.; Hong, S. S.; Song, H. W.

    2011-01-01

    The results of a key comparison of ultra-high vacuum standards at two national metrology institutes (NMIJ/AIST and KRISS) are reported. This bilateral comparison was carried out from May 2010 to October 2010 within the framework of the Asia-Pacific Metrology Programme (APMP) to determine their degrees of equivalence at pressures in the range from 3 × 10-6 Pa to 9 × 10-4 Pa. The pilot institute was NMIJ/AIST. Two spinning rotor gauges and two hot cathode ionization gauges were used as the transfer standards. NMIJ/AIST used two calibration systems: the dynamic expansion system (NMIJ-DES) and two-stage flow-dividing system (NMIJ-TFS). KRISS used the dynamic expansion system. The transfer standards were sufficiently stable to meet the requirements of the comparison compared with those of previous international comparisons owing to some improvements of the protocol and the transfer standards. The ultra-high vacuum standards of NMIJ/AIST and KRISS were found to be equivalent within their claimed uncertainties in the range from 3 × 10-6 Pa to 9 × 10-5 Pa. The NMIJ-DES results, which have smaller uncertainty than NMIJ-TFS, were transferred to the corresponding CCM key comparison, CCM.P-K3, in the range from 3 × 10-6 Pa to 9 × 10-5 Pa and it is shown that the NMIJ values were equivalent to the CCM key comparison reference value within the claimed uncertainties. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (MRA).

  12. Is Structural Subtyping Useful? An Empirical Study

    DTIC Science & Technology

    2009-12-01

    Mellon University Pittsburgh, PA 15213 Abstract Structural subtyping is popular in research languages , but all mainstream object-oriented languages use...nominal subtyping. Since languages with structural subtyping are not in widespread use, the empiri- cal questions of whether and how structural...will provide guidance for language designers who are considering use of this subtyping discipline. Report Documentation Page Form ApprovedOMB No

  13. Secure and Efficient Network Fault Localization

    DTIC Science & Technology

    2012-02-27

    ORGANIZATION NAME(S) AND ADDRESS (ES) Carnegie Mellon University,School of Computer Science,Computer Science Department,Pittsburgh,PA,15213 8. PERFORMING...ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS (ES) 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT...efficiency than previously known protocols for fault localization. Our proposed fault localization protocols also address the security threats that

  14. NASA/DOD Aerospace Knowledge Diffusion Research Project. Paper Sixty Eight, Who is Managing Knowledge? The Implications for Knowledge Production and Management of Global Strategic Alliances in Knowledge-Dependent Industries

    DTIC Science & Technology

    1998-03-01

    United States. Pittsburgh, PA: Carnegie Mellon University Press (August). Cohen, S.S., S . Halimi , and J. Zysman. 1986. "Institutions, Politics, and...San Marcos 333 S . Twin Oaks Valley Rd. San Marcos, CA 92096-0001 vgolich@csusm.edu Thomas E. Pinelli Technology & Distance Learning Officer NASA...1991; Chesnais, 1993; Cohen 1977; Cohen, Halimi , and Zysman, 1986 Crossland, 1975; Gillispie, 1980; Gilpin 1968; Golich

  15. Characterization of the Suspended-Sediment Regime and Bed-Material Gradation of the Mississippi River Basin. Potamology Program (P-I). Report 1, Volume II.

    DTIC Science & Technology

    1981-08-01

    assembling stores at Presque Isle (present site of Erie , Pa.) and building fortifications along the Allegheny. The French also formu- lated plans to...Steubenville-Weirton North Carolina Asheville Pennsylvania Erie Johnstown Pittsburgh D36 State(s) SMSA Tennessee Knoxville Nashville-Davidson...result of lumbering, farming, and mining activi- ties. The Beaver River drainage, situated in northeastern Ohio and northwestern Pennsylvania , covers 3130

  16. Eckert, Wallace John (1902-71)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Computer scientist and astronomer. Born in Pittsburgh, PA, Eckert was a pioneer of the use of IBM punched card equipment for astronomical calculations. As director of the US Nautical Almanac Office he introduced computer methods to calculate and print tables instead of relying on human `computers'. When, later, he became director of the Watson Scientific Computing Laboratory at Columbia Universit...

  17. Photographic copy of original drawing, by Corps of Engineers, U.S. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Photographic copy of original drawing, by Corps of Engineers, U.S. Army, May 1938 (original in possession of Corps of Engineers, U.S. Army, Pittsburgh District, Engineering Division files) Unit 1, project location and index - Johnstown Local Flood Protection Project, Beginning on Conemaugh River approx 3.8 miles downstream from confluence of Little Conemaugh & Stony Creek Rivers at Johnstown, Johnstown, Cambria County, PA

  18. Twelfth annual fluidized bed conference

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1996-12-31

    The Proceedings of the Twelfth Annual Fluidized Bed Conference held November 11-13, 1996 in Pittsburgh, PA are presented. Information is given on: owner`s discussions; new aspects and field upgrades in fluidized bed boilers; manufacturer`s perspectives; fuel considerations; FBC ash reclassification; and beneficial uses of FBC ash. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

  19. Architecture Analysis with AADL: The Speed Regulation Case-Study

    DTIC Science & Technology

    2014-11-01

    Overview Functional Hazard Analysis ( FHA ) Failures inventory with description, classification, etc. Fault-Tree Analysis (FTA) Dependencies between...University Pittsburgh, PA 15213 Julien Delange Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the collection of...Information Operations and Reports , 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any

  20. Department of the Air Force Supporting Data for FY 1991 Budget Estimates Submitted to Congress January 1990. Descriptive Summaries, Research, Development, Test and Evaluation

    DTIC Science & Technology

    1990-05-16

    Redondo Beach. CA. Civilian subcontractors are ITEK (cameras). Lexington. MA; Contraves Georz (telescopes), Pittsburgh. PA; and Kentron (operations and...Improvements include a higher maximum takeoff weight , improved air-to-air gun sight algorithms, digital flight controls, and improved pilot interface...ambient propagation loss , significant penetration of sea water, and good performance in a nuclear environment. C. (U) JUSTIFICATION FOR PROJECTS LESS