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Sample records for plan sismp volume

  1. CPP-603 Underwater Fuel Storage Facility Site Integrated Stabilization Management Plan (SISMP), Volume I

    SciTech Connect

    Denney, R.D.

    1995-10-01

    The CPP-603 Underwater Fuel Storage Facility (UFSF) Site Integrated Stabilization Management Plan (SISMP) has been constructed to describe the activities required for the relocation of spent nuclear fuel (SNF) from the CPP-603 facility. These activities are the only Idaho National Engineering Laboratory (INEL) actions identified in the Implementation Plan developed to meet the requirements of the Defense Nuclear Facilities Safety Board (DNFSB) Recommendation 94-1 to the Secretary of Energy regarding an improved schedule for remediation in the Defense Nuclear Facilities Complex. As described in the DNFSB Recommendation 94-1 Implementation Plan, issued February 28, 1995, an INEL Spent Nuclear Fuel Management Plan is currently under development to direct the placement of SNF currently in existing INEL facilities into interim storage, and to address the coordination of intrasite SNF movements with new receipts and intersite transfers that were identified in the DOE SNF Programmatic and INEL Environmental Restoration and Waste Management Environmental Impact Statement Record, of Decision. This SISMP will be a subset of the INEL Spent Nuclear Fuel Management Plan and the activities described are being coordinated with other INEL SNF management activities. The CPP-603 relocation activities have been assigned a high priority so that established milestones will be meet, but there will be some cases where other activities will take precedence in utilization of available resources. The Draft INEL Site Integrated Stabilization Management Plan (SISMP), INEL-94/0279, Draft Rev. 2, dated March 10, 1995, is being superseded by the INEL Spent Nuclear Fuel Management Plan and this CPP-603 specific SISMP.

  2. DNFSB Recommendation 94-1 Hanford Site Integrated Stabilization Management Plan. Volume 2

    SciTech Connect

    McCormack, R.L.

    1995-08-01

    The Hanford Site Integrated Stabilization Management Plan (SISMP) is being developed in support of the US Department of Energy`s (DOE) Defense Nuclear Facilities Safety Board (DNFSB) Recommendation 94-1 Integrated Program Plan (IPP). Volume 1 of the SISMP identifies the technical scope and costs associated with Hanford Site plans to resolve concerns identified in DNFSB Recommendation 94-1. Volume 2 of the SISMP provides the Resource Loaded Integrated Schedules for Spent Nuclear Fuel Project and Plutonium Finishing Plant activities identified in Volume 1 of the SISMP. Appendix A provides the schedules and progress curves related to spent nuclear fuel management. Appendix B provides the schedules and progress curves related to plutoniumbearing material management. Appendix C provides programmatic logic diagrams that were referenced in Volume 1 of the SISMP.

  3. DNFSB Recommendation 94-1 Hanford Site Integrated Stabilization Management Plan. Volume 2

    SciTech Connect

    Gerber, E.W.

    1995-10-01

    The Hanford Site Integrated Stabilization Management Plan (SISMP) was developed in support of the US Department of Energy`s (DOE) Defense Nuclear Facilities Safety Board (DNFSB) Recommendation 94-1 Integrated Program Plan (IPP). Volume 1 of the SISMP identifies the technical scope and costs associated with Hanford Site plans to resolve concerns identified in DNFSB Recommendation 94-1. Volume 2 of the SISMP provides the Resource Loaded Integrated Schedules for Spent Nuclear Fuel Project and Plutonium Finishing Plant activities identified in Volume 1 of the SISMP. Appendix A provides the schedules and progress curves related to spent nuclear fuel management. Appendix B provides the schedules and progress curves related to plutonium-bearing material management. Appendix C provides programmatic logic diagrams that were referenced in Volume 1 of the SISMP.

  4. DNFSB Recommendation 94-1 Hanford Site Integrated Stabilization Management Plan. Volume 1

    SciTech Connect

    Gerber, E.W.

    1995-10-01

    The US Department of Energy (DOE) has developed an Integrated Program Plan (IPP) to address concerns identified in Defense Nuclear Facilities Safety Board Recommendation 94-1. The IPP describes the actions that DOE plans to implement at its various sites to convert excess fissile materials to forms or conditions suitable for safe interim storage. The baseline IPP was issued as DOE`s Defense Nuclear Facilities Safety Board (DNFSB) Recommendation 94-1 Implementation Plan (IP), which was transmitted to the DNFSB on February 28, 1995. The IPP is being further developed to include complex-wide requirements for research and development and a long-range facility requirements section. The planned additions to the baseline IPP are being developed based on a systems engineering approach that integrates facilities and capabilities at the various DOE sites and focuses on attaining safe interim storage with minimum safety risks and environmental impacts. Each affected DOE site has developed a Site Integrated Stabilization Management Plan (SISMP) to identify individual site plans to implement the DNFSB Recommendation 94-1 and to provide a basis for formulating planned additions to the IPP. The SISMPs were developed based on the objectives, requirements, and commitments identified in the baseline DNFSB Recommendation 94-1 IPP. The SISMPs will be periodically updated to reflect improved integration between DOE sites as identified during the IPP systems engineering evaluations.

  5. Strategic Plan. Volume 1

    NASA Technical Reports Server (NTRS)

    2002-01-01

    The purpose of this document is to present the strategic plan and associated organizational structure that the National Space Biomedical Research Institute (NSBRI) will utilize to achieve the defined mission and objectives provided by NASA. Much of the information regarding the background and establishment of the NSBRI by NASA has been provided in other documentation and will not be repeated in this Strategic Plan. This Strategic Plan is presented in two volumes. Volume I (this volume) begins with an Introduction (Section 2) that provides the Institute's NASA-defined mission and objectives, and the organizational structure adopted to implement these through three Strategic Programs: Countermeasure Research; Education, Training and Outreach; and Cooperative Research and Development. These programs are described in Sections 3 to 5. Each program is presented in a similar way, using four subsections: Goals and Objectives; Current Strategies; Gaps and Modifications; and Resource Requirements. Section 6 provides the administrative infrastructure and total budget required to implement the Strategic Programs and assures that they form a single cohesive plan. This plan will ensure continued success of the Institute for the next five years. Volume II of the Strategic Plan provides an in-depth analysis of the current and future strategic programs of the 12 current NSBRI teams, including their goals, objectives, mutual interactions and schedules.

  6. Nuclear Employment Planning. Volume 4. Data Dictionary

    DTIC Science & Technology

    1990-12-01

    3398 t• DNA-TR-90-33-V4 Nuclear Employment Planning OIPU EWE COPY Volume IV-Data Dictionary Donald W. Doerfler D TIC Lowry A. West ELECTE Debora R...DNA 001 -88-C-0068 Volume IV--Data Dictionary PE 62715HPR - RW 6. AUTHOR(S) TA - RN Donald W. Doerfler , Lowry A. West, WU - DH042980 Debora R. Gleason

  7. Groundwater Monitoring Plan. Volume 2. Final Quality Assurance Project Plan

    DTIC Science & Technology

    1993-10-01

    Samples Added weekly blank for organic-free deionized water and Collected in the Field. filter blank. Specific to Project. 5-9 5.5 Sample Custody Greater...Gmoundwater Monitoing Plan, VOLUME/i Filter blanks will be collected at a frequency of 1 per lot. Organic-free, deionized water will be run through the filter ...using the filtering apparatus used to filter groundwater samples. The water will be collected in the appropriate sample bottles following filtering

  8. Nuclear Employment Planning. Volume 1. Main Report

    DTIC Science & Technology

    1990-12-01

    NA-TR-90-33-V1 ffl’" i L COP AD-B150 535 Nuclear Employment Planning Volume I-Main Report Donald W. Doerfler D TIC Lowry A. West S ELECTE Debora R...Cassel, Ch, Battlefield Nuclear Warfare (BNW) Dick Wright, BNW MAJ Steve Rawlick, DNA Lowry West, LB&M Don Doerfler , LB&M 1. The purpose of the meeting...checks. 4. CACDA personnel were enthusiastic about the project and saw it as something that was long overdue in being done. D W Doerfler PM, LB&M B-1

  9. Draft Strategic Laboratory Missions Plan. Volume II

    SciTech Connect

    1996-03-01

    This volume described in detail the Department`s research and technology development activities and their funding at the Department`s laboratories. It includes 166 Mission Activity Profiles, organized by major mission area, with each representing a discrete budget function called a Budget and Reporting (B & R) Code. The activities profiled here encompass the total research and technology development funding of the laboratories from the Department. Each profile includes a description of the activity and shows how the funding for that activity is distributed among the DOE laboratories as well as universities and industry. The profiles also indicate the principal laboratories for each activity, as well as which other laboratories are involved. The information in this volume is at the core of the Strategic Laboratory Mission Plan. It enables a reader to follow funds from the Department`s appropriation to a specific activity description and to specific R & D performing institutions. This information will enable the Department, along with the Laboratory Operations Board and Congress, to review the distribution of R & D performers chosen to execute the Department`s missions.

  10. Guidelines for Planning in Colleges and Universities. Volume Two, Management and Financial Planning.

    ERIC Educational Resources Information Center

    Pinnell, Charles; Wacholder, Michael

    This volume presents techniques and details involved in developing the management and program planning and the financial planning phases of a total planning system. Also discussed is a suggested organization for implementing a planning system. Areas emphasized under management and program planning are (1) institutional objectives, (2) planning…

  11. DNFSB recommendation 94-1 Hanford site integrated stabilization management plan

    SciTech Connect

    McCormack, R.L.

    1997-05-07

    In May 1994, the Defense Nuclear Facilities Safety Board (DNFSB) issued DNFSB Recommendation 94-1 (Conway 1994), which identified concerns related to US Department of Energy (DOE) management of legacy fissile materials remaining from past defense production activities. The DNFSB expressed concern about the existing storage conditions for these materials and the slow pace at which the conditions were being remediated. The DNFSB also expressed its belief that additional delays in stabilizing these fissile materials would be accompanied by further deterioration of safety and unnecessary increased risks to workers and the public. In February 1995, DOE issued the DNFSB Recommendation 94-1 Implementation Plan (O`Leary 1995) to address the concerns identified in DNFSB Recommendation 94-1. The Implementation Plan (IP) identifies several DOE commitments to achieve safe interim storage for the legacy fissile materials, and constitutes DOE`s baseline DNFSB Recommendation 94-1 Integrated Program Plan (IPP). The IPP describes the actions DOE plans to implement within the DOE complex to convert its excess fissile materials to forms or conditions suitable for safe interim storage. The IPP was subsequently supplemented with an Integrated Facilities Plan and a Research and Development Plan, which further develop complex-wide research and development and long-range facility requirements and plans. The additions to the baseline IPP were developed based on a systems engineering approach that integrated facilities and capabilities at the various DOE sites and focused on attaining safe interim storage with minimum safety risks and environmental impacts. Each affected DOE site has developed a Site Integrated Stabilization Management Plan (SISMP) to identify individual site plans to implement the DNFSB Recommendation 94-1 IPP. The SISMPs were developed based on the objectives, requirements, and commitments identified in the DNFSB Recommendation 94-1 IP. The SISMPs also supported

  12. U.S. Department of Education FY 1999 Annual Plan, Volume 2: Program Performance Plans.

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC.

    The Government Performance and Results Act of 1993 called for the U.S. Department of Education to prepare an Annual Performance Plan which links the Department's budget request with its Strategic Plan. To meet that directive, Volume 2 of the Department's Strategic Plan for 1999 is presented here. It includes the program performance plans that…

  13. Long Range Facilities Planning Plan Guide Lines. Volume 1

    DTIC Science & Technology

    1982-04-01

    Maritime Administration invited Richard M. Muther to address the group on the subject of long range facility planning. Atlanta, Georgia. by MARAD was...NASSCO submitted a contract proposal to MARAD for cost sharing the development of NASSCO’s Long Range Facility Plan. Richard M. Muther addressed...given from United States A week-long seminar sponsored to train facility planners shipyards in the Muther tech- niques of long range facility planning

  14. Routine Radiological Environmental Monitoring Plan. Volume 1

    SciTech Connect

    Bechtel Nevada

    1999-12-31

    The U.S. Department of Energy manages the Nevada Test Site in a manner that meets evolving DOE Missions and responds to the concerns of affected and interested individuals and agencies. This Routine Radiological Monitoring Plan addressess complicance with DOE Orders 5400.1 and 5400.5 and other drivers requiring routine effluent monitoring and environmental surveillance on the Nevada Test Site. This monitoring plan, prepared in 1998, addresses the activities conducted onsite NTS under the Final Environmental Impact Statement and Record of Decision. This radiological monitoring plan, prepared on behalf of the Nevada Test Site Landlord, brings together sitewide environmental surveillance; site-specific effluent monitoring; and operational monitoring conducted by various missions, programs, and projects on the NTS. The plan provides an approach to identifying and conducting routine radiological monitoring at the NTS, based on integrated technical, scientific, and regulatory complicance data needs.

  15. Guidelines for Planning in Colleges and Universities. Volume 5: Physical Plant Planning, Utilities Studies.

    ERIC Educational Resources Information Center

    Pinnell, Charles; Wacholder, Michael

    The fifth and final volume of a series concerned with higher educational facilities planning expands the discussion of the utilities planning process initiated in the overview of volume one. Three major classes of utilities--energy utilities, service utilities, and communications utilities are studied. Their influences on the overall physical…

  16. OCCUPATIONAL EDUCATION--PLANNING AND PROGRAMMING. VOLUME TWO.

    ERIC Educational Resources Information Center

    KOTZ, ARNOLD

    ADDITIONAL POSITION PAPERS BASED ON INFORMATION GATHERED IN THE RECONNAISSANCE SURVEYS OF PLANNING AND PROGRAMING IN OCCUPATIONAL EDUCATION, REPORTED IN VOLUME ONE (VT 005 041), ARE PRESENTED. PART IV, CONCERNED WITH PROGRAM STRUCTURE AND BUDGETING AND THEIR RELATION TO THE PLANNING PROCESS, INCLUDES THE PAPERS--(1) "CURRENT POLICIES AND…

  17. Final consolidated action plan to Tiger Team. Volume 1

    SciTech Connect

    Not Available

    1992-10-01

    This document is a compilation of different issues identified by the Tiger Teams at the several locations of the Sandia National Laboratory. In this volume there are findings/concerns and the resultant responses and planned actions for these issues. Also included are the schedules and costs for the planned actions.

  18. Savannah River Site Environmental Implementation Plan. Volume 2, Protection programs

    SciTech Connect

    Not Available

    1989-08-01

    Formal sitewide environmental planning at the . Savannah River Site (SRS) began in 1986 with the development and adoption of the Strategic Environmental Plan. The Strategic Environmental Plan describes the philosophy, policy, and overall program direction of environmental programs for the operation of the SRS. The Strategic Environmental Plan (Volume 2) provided the basis for development of the Environmental Implementation Plan (EIP). The EIP is the detailed, comprehensive environmental master plan for operating contractor organizations at the SRS. The EIP provides a process to ensure that all environmental requirements and obligations are being met by setting specific measurable goals and objectives and strategies for implementation. The plan is the basis for justification of site manpower and funding requests for environmental projects and programs over a five-year planning period.

  19. Agricultural Products: Program Planning Guide: Volume 4.

    ERIC Educational Resources Information Center

    Welton, Richard; Robb, Sam

    The program planning guide for agricultural products was written to assist Applied Biological and Agricultural Occupations (ABAO) teachers in enriching existing programs and/or to provide the basis for expansion of offerings to include additional materials for the cluster areas of meat and meat byproducts, dairy processing, fruit and vegetable…

  20. Forestry: Program Planning Guide: Volume 7.

    ERIC Educational Resources Information Center

    Roth, Paul L.; And Others

    The program planning guide for forestry was written to assist Applied Biological and Agricultural Occupations (ABAO) teachers in enriching existing programs and/or to provide the basis for expansion of offerings to include additional materials for the cluster areas of forests, forest protection, logging, wood utilization, recreation, and special…

  1. Ornamental Horticulture: Program Planning Guide: Volume 5.

    ERIC Educational Resources Information Center

    Ross, Roger R.; Stitt, Thomas R.

    The program planning guide for ornamental horticulture was written to assist Applied Biological and Agricultural Occupations (ABAO) teachers in enriching existing programs and/or to provide the basis for expansion of offerings to include additional materials for the cluster areas of arboriculture, floriculture, greenhouse operation and management,…

  2. Limitations of the planning organ at risk volume (PRV) concept

    SciTech Connect

    Stroom, Joep C. . E-mail: j.stroom@nki.nl; Heijmen, Ben J.M.

    2006-09-01

    Purpose: Previously, we determined a planning target volume (PTV) margin recipe for geometrical errors in radiotherapy equal to M{sub T} = 2{sigma} + 0.7{sigma}, with {sigma} and {sigma} standard deviations describing systematic and random errors, respectively. In this paper, we investigated margins for organs at risk (OAR), yielding the so-called planning organ at risk volume (PRV). Methods and Materials: For critical organs with a maximum dose (D{sub max}) constraint, we calculated margins such that D{sub max} in the PRV is equal to the motion averaged D{sub max} in the (moving) clinical target volume (CTV). We studied margins for the spinal cord in 10 head-and-neck cases and 10 lung cases, each with two different clinical plans. For critical organs with a dose-volume constraint, we also investigated whether a margin recipe was feasible. Results: For the 20 spinal cords considered, the average margin recipe found was: M{sub R} = 1.6{sigma} + 0.2{sigma} with variations for systematic and random errors of 1.2{sigma} to 1.8{sigma} and -0.2{sigma} to 0.6{sigma}, respectively. The variations were due to differences in shape and position of the dose distributions with respect to the cords. The recipe also depended significantly on the volume definition of D{sub max}. For critical organs with a dose-volume constraint, the PRV concept appears even less useful because a margin around, e.g., the rectum changes the volume in such a manner that dose-volume constraints stop making sense. Conclusion: The concept of PRV for planning of radiotherapy is of limited use. Therefore, alternative ways should be developed to include geometric uncertainties of OARs in radiotherapy planning.

  3. Federal Facilities Compliance Act, Draft Site Treatment Plan: Compliance Plan Volume. Part 2, Volume 2

    SciTech Connect

    1994-08-31

    This document presents the details of the implementation of the Site Treatment Plan developed by Ames Laboratory in compliance with the Federal Facilities Compliance Act. Topics discussed in this document include: implementation of the plan; milestones; annual updates to the plan; inclusion of new waste streams; modifications of the plan; funding considerations; low-level mixed waste treatment plan and schedules; and TRU mixed waste streams.

  4. Draft Site Treatment Plan (DSTP), Volumes I and II

    SciTech Connect

    D`Amelio, J.

    1994-08-30

    Site Treatment Plans (STP) are required for facilities at which the DOE generates or stores mixed waste. This Draft Site Treatment Plan (DSTP) the second step in a three-phase process, identifies the currently preferred options for treating mixed waste at the Savannah River Site (SRS) or for developing treatment technologies where technologies do not exist or need modification. The DSTP reflects site-specific preferred options, developed with the state`s input and based on existing available information. To the extent possible, the DSTP identifies specific treatment facilities for treating the mixed waste and proposes schedules. Where the selection of specific treatment facilities is not possible, schedules for alternative activities such as waste characterization and technology assessment are provided. All schedule and cost information presented is preliminary and is subject to change. The DSTP is comprised of two volumes: this Compliance Plan Volume and the Background Volume. This Compliance Plan Volume proposes overall schedules with target dates for achieving compliance with the land disposal restrictions (LDR) of RCRA and procedures for converting the target dates into milestones to be enforced under the Order. The more detailed discussion of the options contained in the Background Volume is provided for informational purposes only.

  5. Approved Site Treatment Plan, Volumes 1 and 2. Revision 4

    SciTech Connect

    Helmich, E.H.; Molen, G.; Noller, D.

    1996-03-22

    The US Department of Energy, Savannah River Operations Office (DOE-SR), has prepared the Site Treatment Plan (STP) for Savannah River Site (SRS) mixed wastes in accordance with RCRA Section 3021(b), and SCDHEC has approved the STP (except for certain offsite wastes) and issued an order enforcing the STP commitments in Volume 1. DOE-SR and SCDHEC agree that this STP fulfills the requirements contained in the FFCAct, RCRA Section 3021, and therefore, pursuant to Section 105(a) of the FFCAct (RCRA Section 3021(b)(5)), DOE`s requirements are to implement the plan for the development of treatment capacities and technologies pursuant to RCRA Section 3021. Emerging and new technologies not yet considered may be identified to manage waste more safely, effectively, and at lower cost than technologies currently identified in the plan. DOE will continue to evaluate and develop technologies that offer potential advantages in public acceptance, privatization, consolidation, risk abatement, performance, and life-cycle cost. Should technologies that offer such advantages be identified, DOE may request a revision/modification of the STP in accordance with the provisions of Consent Order 95-22-HW. The Compliance Plan Volume (Volume 1) identifies project activity schedule milestones for achieving compliance with Land Disposal Restrictions (LDR). Information regarding the technical evaluation of treatment options for SRS mixed wastes is contained in the Background Volume (Volume 2) and is provided for information.

  6. Volume visualization in radiation treatment planning.

    PubMed

    Pelizzari, C A; Chen, G T

    2000-12-01

    Radiation treatment planning (RTP), historically an image-intensive discipline and one of the first areas in which 3D information from imaging was clinically applied, has become even more critically dependent on accurate 3D definition of target and non-target structures in recent years with the advent of conformal radiation therapy. In addition to the interactive display of wireframe or shaded surface models of anatomic objects, proposed radiation beams, beam modifying devices, and calculated dose distributions, recently significant use has been made of direct visualization of relevant anatomy from image data. Dedicated systems are commercially available for the purpose of geometrically optimizing beam placement, implementing in virtual reality the functionality of standard radiation therapy simulators. Such "CT simulation" systems rely heavily on 3D visualization and on reprojection of image data to produce simulated radiographs for comparison with either diagnostic-quality radiographs made on a simulator or megavoltage images made using the therapeutic beams themselves. Although calculation and analysis of dose distributions is an important component of radiation treatment design, geometric targeting with optimization based on 3D anatomic information is frequently performed as a separate step independent of dose calculations.

  7. Space station human productivity study. Volume 5: Management plans

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The 67 Management Plans represent recommended study approaches for resolving 108 of the 305 Issues which were identified. Each study Management Plan is prepared in three formats: Management Plan Overview (lists the subsumed Issues, study background, and related overview information); Study Plan (details the study approach by tasks, lists special needs, and describes expected study products); Schedule-Task Flow (provides a time-lined schedule for the study tasks and resource requirements). The Management Relationships Matrix, included in this volume, shows the data input-output relationships among all recommended studies. A listing is also included which cross-references the unresolved requirements to Issues to management plans. A glossary of all abbreviations utilized is provided.

  8. U.S. Department of Education FY 2000 Annual Plan, Volume 2: Program Performance Plans.

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC.

    This volume of the Department of Education's (ED) annual plan contains the program-performance plans to support efforts to reach the department's four goals. These four goals are as follows: (1) help all students reach challenging academic standards so that they are prepared for responsible citizenship, further learning, and productive employment;…

  9. Systems Engineering Management Plan. Volume 5 of the MRS Project Management Plan

    SciTech Connect

    Not Available

    1994-01-01

    The purpose of this Monitored Retrievable Storage (MRS) Project Systems Engineering Management Plan (SEMP) is to define and establish the MRS Project Systems Engineering process that implements the approved policy and requirements of the Office of Civilian Radioactive Waste Management (OCRWM) for the US Department of Energy (DOE). This plan is Volume 5 of the MRS Project Management Plan (PMP). This plan provides the framework for implementation of systems engineering on the MRS Project consistent with DOE Order 4700.1, the OCRWM Program Management System Manual (PMSM), and the OCRWM Systems Engineering Management Plan (SEMP).

  10. Nuclear Employment Planning. Volume 3. Data Flow Diagrams

    DTIC Science & Technology

    1990-12-01

    3398 I-’ DNA-TR-90-33-V3 Nuclear Employment Planning Volume III-Data Flow Diagrams Donald W. Doerfler D T IC Lowry A. West E1T Debora R. GleasonE EC LB&M...ASSOCIATES ATTN: ATSI-CD (J ORDWAY) 2 CYS ATTN: D R GLEASON 2 CYS ATTN: D W DOERFLER U S ARMY LOGISTICS CENTER 2 CYS ATTN: L A WEST ATTN: ATZL.S (BRIAN WOOD

  11. [Clinical to planning target volume margins in prostate cancer radiotherapy].

    PubMed

    Ramiandrisoa, F; Duvergé, L; Castelli, J; Nguyen, T D; Servagi-Vernat, S; de Crevoisier, R

    2016-10-01

    The knowledge of inter- and intrafraction motion and deformations of the intrapelvic target volumes (prostate, seminal vesicles, prostatectomy bed and lymph nodes) as well as the main organs at risk (bladder and rectum) allow to define rational clinical to planning target volume margins, depending on the different radiotherapy techniques and their uncertainties. In case of image-guided radiotherapy, prostate margins and seminal vesicles margins can be between 5 and 10mm. The margins around the prostatectomy bed vary from 10 to 15mm and those around the lymph node clinical target volume between 7 and 10mm. Stereotactic body radiotherapy allows lower margins, which are 3 to 5mm around the prostate. Image-guided and stereotactic body radiotherapy with adequate margins allow finally moderate or extreme hypofractionation.

  12. Guidelines for Planning in Colleges and Universities. Volume 4: Physical Plant Planning, Facilities Studies.

    ERIC Educational Resources Information Center

    Pinnell, Charles; Wacholder, Michael

    The fourth of a five-volume series concerned with higher educational planning provides techniques for the estimation of an institution's facility requirements. The facilities are discussed within the framework of two broad categories--(1) academic program facilities, and (2) residential housing facilities. The academic program facilities provide…

  13. Guidance and Control Software Project Data - Volume 1: Planning Documents

    NASA Technical Reports Server (NTRS)

    Hayhurst, Kelly J. (Editor)

    2008-01-01

    The Guidance and Control Software (GCS) project was the last in a series of software reliability studies conducted at Langley Research Center between 1977 and 1994. The technical results of the GCS project were recorded after the experiment was completed. Some of the support documentation produced as part of the experiment, however, is serving an unexpected role far beyond its original project context. Some of the software used as part of the GCS project was developed to conform to the RTCA/DO-178B software standard, "Software Considerations in Airborne Systems and Equipment Certification," used in the civil aviation industry. That standard requires extensive documentation throughout the software development life cycle, including plans, software requirements, design and source code, verification cases and results, and configuration management and quality control data. The project documentation that includes this information is open for public scrutiny without the legal or safety implications associated with comparable data from an avionics manufacturer. This public availability has afforded an opportunity to use the GCS project documents for DO-178B training. This report provides a brief overview of the GCS project, describes the 4-volume set of documents and the role they are playing in training, and includes the planning documents from the GCS project. Volume 1 contains five appendices: A. Plan for Software Aspects of Certification for the Guidance and Control Software Project; B. Software Development Standards for the Guidance and Control Software Project; C. Software Verification Plan for the Guidance and Control Software Project; D. Software Configuration Management Plan for the Guidance and Control Software Project; and E. Software Quality Assurance Activities.

  14. Optimized planning target volume for intact cervical cancer.

    PubMed

    Khan, Alvin; Jensen, Lindsay G; Sun, Shuai; Song, William Y; Yashar, Catheryn M; Mundt, Arno J; Zhang, Fu-Quan; Jiang, Steve B; Mell, Loren K

    2012-08-01

    To model interfraction clinical target volume (CTV) variation in patients with intact cervical cancer and design a planning target volume (PTV) that minimizes normal tissue dose while maximizing CTV coverage. We analyzed 50 patients undergoing external-beam radiotherapy for intact cervical cancer using daily online cone-beam computed tomography (CBCT). The CBCTs (n = 972) for each patient were rigidly registered to the planning CT. The CTV was delineated on the planning CT (CTV(0)) and the set of CBCTs ({CTV(1)-CTV(25)}). Manual (n = 98) and automated (n = 668) landmarks were placed over the surface of CTV(0) with reference to defined anatomic structures. Normal vectors were extended from each landmark, and the minimum length required for a given probability of encompassing CTV(1)-CTV(25) was computed. The resulting expansions were used to generate an optimized PTV. The mean (SD; range) normal vector length to ensure 95% coverage was 4.3 mm (2.7 mm; 1-16 mm). The uniform expansion required to ensure 95% probability of CTV coverage was 13 mm. An anisotropic margin of 20 mm anteriorly and posteriorly and 10 mm superiorly, inferiorly, and laterally also would have ensured a 95% probability of CTV coverage. The volume of the 95% optimized PTV (1470 cm(3)) was significantly lower than both the anisotropic PTV (2220 cm(3)) and the uniformly expanded PTV (2110 cm(3)) (p < 0.001). For a 95% probability of CTV coverage, normal lengths of 1-3 mm were found along the superior and lateral regions of CTV(0), 5-10 mm along the interfaces of CTV(0) with the bladder and rectum, and 10-14 mm along the anterior surface of CTV(0) at the level of the uterus. Optimizing PTV definition according to surface landmarking resulted in a high probability of CTV coverage with reduced PTV volumes. Our results provide data justifying planning margins to use in practice and clinical trials. Copyright © 2012 Elsevier Inc. All rights reserved.

  15. Optimized Planning Target Volume for Intact Cervical Cancer

    SciTech Connect

    Khan, Alvin; Jensen, Lindsay G.; Sun Shuai; Song, William Y.; Yashar, Catheryn M.; Mundt, Arno J.; Zhang Fuquan; Jiang, Steve B.; Mell, Loren K.

    2012-08-01

    Purpose: To model interfraction clinical target volume (CTV) variation in patients with intact cervical cancer and design a planning target volume (PTV) that minimizes normal tissue dose while maximizing CTV coverage. Methods and Materials: We analyzed 50 patients undergoing external-beam radiotherapy for intact cervical cancer using daily online cone-beam computed tomography (CBCT). The CBCTs (n = 972) for each patient were rigidly registered to the planning CT. The CTV was delineated on the planning CT (CTV{sub 0}) and the set of CBCTs ({l_brace}CTV{sub 1}-CTV{sub 25}{r_brace}). Manual (n = 98) and automated (n = 668) landmarks were placed over the surface of CTV{sub 0} with reference to defined anatomic structures. Normal vectors were extended from each landmark, and the minimum length required for a given probability of encompassing CTV{sub 1}-CTV{sub 25} was computed. The resulting expansions were used to generate an optimized PTV. Results: The mean (SD; range) normal vector length to ensure 95% coverage was 4.3 mm (2.7 mm; 1-16 mm). The uniform expansion required to ensure 95% probability of CTV coverage was 13 mm. An anisotropic margin of 20 mm anteriorly and posteriorly and 10 mm superiorly, inferiorly, and laterally also would have ensured a 95% probability of CTV coverage. The volume of the 95% optimized PTV (1470 cm{sup 3}) was significantly lower than both the anisotropic PTV (2220 cm{sup 3}) and the uniformly expanded PTV (2110 cm{sup 3}) (p < 0.001). For a 95% probability of CTV coverage, normal lengths of 1-3 mm were found along the superior and lateral regions of CTV{sub 0}, 5-10 mm along the interfaces of CTV{sub 0} with the bladder and rectum, and 10-14 mm along the anterior surface of CTV{sub 0} at the level of the uterus. Conclusion: Optimizing PTV definition according to surface landmarking resulted in a high probability of CTV coverage with reduced PTV volumes. Our results provide data justifying planning margins to use in practice and

  16. Planning Documents Known Releases SWMUs Tooele Army Depot Tooele, Utah. Volume 1: Corrective Measures Study Work Plan

    DTIC Science & Technology

    2000-02-01

    SECOND REVISED FINAL DET:-, PLANNING DOCUMENTS KNOWN RELEASES SWMUs TOOELE ARMY DEPOT TOOELE, UTAH Volume I: CORRECTIVE MEASURES STUDY WORK PLAN...FINAL PLANNING DOCUMENTS KNOWN RELEASES SWMUs TOOELE ARMY DEPOT TOOELE, UTAH Volume I: CORRECTIVE MEASURES STUDY WORK PLAN Contract DACA31-94-D-0060...2-1 3.0 X-RAY LAGOON (SWMU 3) ..................................................................... 3-1 3.1 SWMU BACKGROUND

  17. U.S. Department of Education FY 1999 Annual Plan. Volume 1: Objective Performance Plans and Data Quality.

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC.

    The Government Performance and Results Act of 1993 called for the U.S. Department of Education to prepare an Annual Performance Plan which links the Department's budget request with its Strategic Plan. To meet that directive, Volume 1 of the Department's Strategic Plan for 1999 is presented here. It includes objective performance plans and shows…

  18. University of California, Irvine, Student Affirmative Action Five-Year Plan and Planning Process, 1984-1988. Volume I.

    ERIC Educational Resources Information Center

    Galligani, Dennis J.

    This first volume of the University of California, Irvine, (UCI) Student Affirmative Action (SAA) Five-Year Plan provides an overview of the plan and the planning process, lists campus SAA goals and objectives, summarizes campus SAA activities, and describes the research and evaluation components of the plan. Topics include: the historical context…

  19. Sodium fast reactor safety and licensing research plan. Volume II.

    SciTech Connect

    Ludewig, H.; Powers, D. A.; Hewson, John C.; LaChance, Jeffrey L.; Wright, A.; Phillips, J.; Zeyen, R.; Clement, B.; Garner, Frank; Walters, Leon; Wright, Steve; Ott, Larry J.; Suo-Anttila, Ahti Jorma; Denning, Richard; Ohshima, Hiroyuki; Ohno, S.; Miyhara, S.; Yacout, Abdellatif; Farmer, M.; Wade, D.; Grandy, C.; Schmidt, R.; Cahalen, J.; Olivier, Tara Jean; Budnitz, R.; Tobita, Yoshiharu; Serre, Frederic; Natesan, Ken; Carbajo, Juan J.; Jeong, Hae-Yong; Wigeland, Roald; Corradini, Michael; Thomas, Justin; Wei, Tom; Sofu, Tanju; Flanagan, George F.; Bari, R.; Porter D.; Lambert, J.; Hayes, S.; Sackett, J.; Denman, Matthew R.

    2012-05-01

    Expert panels comprised of subject matter experts identified at the U.S. National Laboratories (SNL, ANL, INL, ORNL, LBL, and BNL), universities (University of Wisconsin and Ohio State University), international agencies (IRSN, CEA, JAEA, KAERI, and JRC-IE) and private consultation companies (Radiation Effects Consulting) were assembled to perform a gap analysis for sodium fast reactor licensing. Expert-opinion elicitation was performed to qualitatively assess the current state of sodium fast reactor technologies. Five independent gap analyses were performed resulting in the following topical reports: (1) Accident Initiators and Sequences (i.e., Initiators/Sequences Technology Gap Analysis), (2) Sodium Technology Phenomena (i.e., Advanced Burner Reactor Sodium Technology Gap Analysis), (3) Fuels and Materials (i.e., Sodium Fast Reactor Fuels and Materials: Research Needs), (4) Source Term Characterization (i.e., Advanced Sodium Fast Reactor Accident Source Terms: Research Needs), and (5) Computer Codes and Models (i.e., Sodium Fast Reactor Gaps Analysis of Computer Codes and Models for Accident Analysis and Reactor Safety). Volume II of the Sodium Research Plan consolidates the five gap analysis reports produced by each expert panel, wherein the importance of the identified phenomena and necessities of further experimental research and code development were addressed. The findings from these five reports comprised the basis for the analysis in Sodium Fast Reactor Research Plan Volume I.

  20. Selected Bibliographies and State-of-the-Art Review for Health Manpower Planning. Volume 3: Health Manpower Planning References. International Health Planning Reference Series.

    ERIC Educational Resources Information Center

    White (E.H.) Co., San Francisco, CA.

    Intended as a companion piece to volume 3 in the Method Series, Health Manpower Planning (CE 024 231), this third of six volumes in the International Health Planning Reference Series is a combined literature review and annotated bibliography dealing with health manpower planning for developing countries. The review identifies literature relevant…

  1. University of California, Irvine, Student Affirmative Action Five-Year Plan and Planning Process, 1984-1988. Volume II.

    ERIC Educational Resources Information Center

    Galligani, Dennis J.

    This second volume of the University of California, Irvine (UCI), Student Affirmative Action (SAA) Five-Year Plan contains the complete student affirmative action plans as submitted by 33 academic and administrative units at UCI. The volume is organized by type of unit: academic units, academic retention units, outreach units, and student life…

  2. [Planned 3-dimensional low-volume conformal irradiation of a local prostatic carcinoma].

    PubMed

    Wachter, S; Gerstner, N; Dieckmann, K; Stampfer, M; Hawliczek, R; Pötter, R

    1997-05-01

    Recent data have shown a significant reduction of acute side effects by means of a three-dimensional planned conformal radiotherapy of carcinoma of the prostate compared to treatment techniques used before. Theoretically, an optimized field coverage of the planning target volume should result in a reduction of treated bladder and rectum volumes. We studied the effects of individualized blocks on treatment volumes, planning target volumes, irradiated bladder and rectum volumes on basis of three-dimensional treatment planning by means of beam's-eye-view technique. We compared dose-volume-histograms of 2 different planning models, a (fictitious) open 4-field-box-technique and a technique with conformal blocked fields designed from the beam's-eye-view display (prescribed dose 66 Gy, daily single fraction 2 Gy). Plans of 115 patients with localized prostate cancer treated from January 1994 to February 1996 were analyzed. Using individualized fields treatment volume (covered by the 90%-isodose) was reduced by 23% on the average in comparison to the planning model without blocks. The averaged difference of treated volume and planning target volume, as a grade of efficiency of conformation, was reduced by 38% (496 cm3 303 cm3) using individualized blocks. 23% of the treated bladder volume and 13% of the treated rectum volume had been saved on the average. Nevertheless, at least 11.5% of the bladder volume and 27.6% of the contoured rectum volume were treated with the prescribed dose (55 Gy = 100%). The comparison of dose-volume-histogram-data showed that especially high dose volumes of organs at risk had been saved by means of individualized blocks created from the beam's-eye-view. The blocks did not affect the dose distribution of the planning target volume adversely. Consequently the impact of these data on the extent of side effects and local tumor control has to be proven.

  3. Savannah River Site Approved Site Treatment Plan, 2001 Annual Update (Volumes I and II)

    SciTech Connect

    Lawrence, B.

    2001-04-30

    The Compliance Plan Volume (Volume I) identifies project activity scheduled milestones for achieving compliance with Land Disposal Restrictions. Information regarding the technical evaluation of treatment options for SRS mixed wastes is contained in the Background Volume (Volume II) and is provided for information.

  4. Routine Radiological Environmental Monitoring Plan, Volume 2 Appendices

    SciTech Connect

    Bechtel Nevada

    1998-12-31

    Supporting material for the plan includes: QUALITY ASSURANCE, ANALYSIS, AND SAMPLING PLAN FOR NTS AIR; QUALITY ASSURANCE, ANALYSIS, AND SAMPLING PLAN FOR WATER ON AND OFF THE NEVADA TEST SITE; QUALITY ASSURANCE, ANALYSIS, AND SAMPLING PLAN FOR NTS BIOTA; QUALITY ASSURANCE, ANALYSIS, AND SAMPLING PLAN FOR DIRECT RADIATION MONITORING; DATA QUALITY OBJECTIVES PROCESS; VADOSE ZONE MONITORING PLAN CHECKLIST.

  5. National Data Program for the Marine Environment Technical Development Plan. Final Report, Volume Two.

    ERIC Educational Resources Information Center

    System Development Corp., Santa Monica, CA.

    A national data program for the marine environment is recommended. Volume 2 includes: (1) objectives, scope, and methodology; (2) summary of the technical development plan; (3) agency development plans - Great Lakes and coastal development and (4) marine data network development plans. (Author)

  6. National Data Program for the Marine Environment Technical Development Plan. Final Report, Volume Two.

    ERIC Educational Resources Information Center

    System Development Corp., Santa Monica, CA.

    A national data program for the marine environment is recommended. Volume 2 includes: (1) objectives, scope, and methodology; (2) summary of the technical development plan; (3) agency development plans - Great Lakes and coastal development and (4) marine data network development plans. (Author)

  7. Savannah River Site environmental implementation plan. Volume 1, Executive summary

    SciTech Connect

    Not Available

    1989-08-01

    Formal sitewide environmental planning at the Savannah River Site (SRS) began in 1986 with the development and adoption of the Strategic Environmental Plan. The Strategic Environmental Plan describes the philosophy, policy, and overall program direction of environmental programs for the operation of the SRS. The Strategic Environmental Plan provided the basis for development of the Environmental Implementation Plan (EIP). The EIP is the detailed, comprehensive environmental master plan for operating contractor organizations at the SRS. The EIP provides a process to ensure that all environmental requirements and obligations are being met by setting specific measurable goals and objectives and strategies for implementation. The plan is the basis for justification of site manpower and funding requests for environmental projects and programs over a five-year planning period.

  8. Turnaround Operations Analysis for OTV. Volume 3: Technology Development Plan

    NASA Technical Reports Server (NTRS)

    1988-01-01

    An integrated technology development plan for the technologies required to process both GBOTVs and SBOTVs are described. The plan includes definition of the tests and experiments to be accomplished on the ground, in a Space Shuttle Sortie Mission, on an Expendable Launch Vehicle, or at the Space Station as a Technology Development Mission (TDM). The plan reflects and accommodates current and projected research and technology programs where appropriate.

  9. Business Plan : Supplemental Draft Environmental Impact Statement, Volume 2, Appendices.

    SciTech Connect

    United States. Bonneville Power Administration.

    1995-02-01

    This document contains the appendices for the Bonneville Power Administration (BPA) Business Plan: Supplemental Draft Environmental Impact Statement. Included are: BPA products and services; Rate design; Methodology and assumptions for numerical analysis; Retail utility operations; Comments and responses to the draft business plan EIS.

  10. Studies in Family Planning, Volume 3 Number 2.

    ERIC Educational Resources Information Center

    Population Council, New York, NY.

    A new design for government family planning programs is proposed in "Family Planning Programs: An Economic Approach," the principal article in this monthly publication of The Population Council. The design is intended primarily for low-income countries that seek large and rapid reductions in fertility. Thirteen elements of the proposed system of…

  11. Bibliography of Family Planning and Population, Volume 1 Number 3.

    ERIC Educational Resources Information Center

    Linzell, Dinah, Comp.

    Compiled from the world's research literature, this bi-monthly classified list of references on population and family planning emphasizes recently published material, primarily journal literature. Topics covered include: population and fertility; reproductive behaviour; the family; education in population, family planning, and sex; family…

  12. Studies in Family Planning. Volume 2, Number 3.

    ERIC Educational Resources Information Center

    Worth, George; And Others

    This year's annual review of family planning in Korea and Taiwan is represented in three articles. The first, "Korea/Taiwan 1970: Report on the National Family Planning Programs," separately views the program administration, budget, personnel, and evaluation, as well as the various methods employed in controlling the number of births,…

  13. Planning Educational Change: Volume II. Human Resources in School Desegregation.

    ERIC Educational Resources Information Center

    Chesler, Mark A.; And Others

    This manual is designed to assist school superintendents in planning and implementing complete school desegregation as prescribed by law. Chapters I through VI discuss specific techniques applicable to the following stages of the desegregation planning process: Identification of goals; diagnosing the school situation; development, testing, and…

  14. Studies in Family Planning, Volume 2 Number 12.

    ERIC Educational Resources Information Center

    Population Council, New York, NY.

    A typology of incentives and the general effects of incentives for family planning are discussed in "Incentives in the Diffusion of Family Planning Innovations," the first of three studies in this monthly publication of The Population Council. A brief review of the history of incentives and their present status in the fields is given, together…

  15. Studies in Family Planning, Volume 2 Number 5.

    ERIC Educational Resources Information Center

    Population Council, New York, NY.

    This paper summarizes family planning activities and accomplishments during 1969 and 1970 in Morocco and Tunisia, and then sets forth 12 criteria that are utilized to evaluate the overall progress of the family planning programs in the two countries. These criteria serve to measure the readiness and prospects for the development of viable family…

  16. Studies in Family Planning. Volume 2, Number 3.

    ERIC Educational Resources Information Center

    Worth, George; And Others

    This year's annual review of family planning in Korea and Taiwan is represented in three articles. The first, "Korea/Taiwan 1970: Report on the National Family Planning Programs," separately views the program administration, budget, personnel, and evaluation, as well as the various methods employed in controlling the number of births,…

  17. Studies in Family Planning, Volume 2 Number 12.

    ERIC Educational Resources Information Center

    Population Council, New York, NY.

    A typology of incentives and the general effects of incentives for family planning are discussed in "Incentives in the Diffusion of Family Planning Innovations," the first of three studies in this monthly publication of The Population Council. A brief review of the history of incentives and their present status in the fields is given, together…

  18. MCC/shuttle test plan. Volume 1: Philosophy and guidelines

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The Mission Control Center/Shuttle Test Plan is defined from development through operations to a level of detail which will support the National Aeronautics and Space Administration and contractor management in the following areas: test management, test tool development, and resource and schedule planning.

  19. Bibliography of Family Planning and Population, Volume 1 Number 3.

    ERIC Educational Resources Information Center

    Linzell, Dinah, Comp.

    Compiled from the world's research literature, this bi-monthly classified list of references on population and family planning emphasizes recently published material, primarily journal literature. Topics covered include: population and fertility; reproductive behaviour; the family; education in population, family planning, and sex; family…

  20. Combined Recipe for Clinical Target Volume and Planning Target Volume Margins

    SciTech Connect

    Stroom, Joep; Gilhuijs, Kenneth; Vieira, Sandra; Chen, Wei; Salguero, Javier; Moser, Elizabeth; Sonke, Jan-Jakob

    2014-03-01

    Purpose: To develop a combined recipe for clinical target volume (CTV) and planning target volume (PTV) margins. Methods and Materials: A widely accepted PTV margin recipe is M{sub geo} = aΣ{sub geo} + bσ{sub geo}, with Σ{sub geo} and σ{sub geo} standard deviations (SDs) representing systematic and random geometric uncertainties, respectively. On the basis of histopathology data of breast and lung tumors, we suggest describing the distribution of microscopic islets around the gross tumor volume (GTV) by a half-Gaussian with SD Σ{sub micro}, yielding as possible CTV margin recipe: M{sub micro} = ƒ(N{sub i}) × Σ{sub micro}, with N{sub i} the average number of microscopic islets per patient. To determine ƒ(N{sub i}), a computer model was developed that simulated radiation therapy of a spherical GTV with isotropic distribution of microscopic disease in a large group of virtual patients. The minimal margin that yielded D{sub min} <95% in maximally 10% of patients was calculated for various Σ{sub micro} and N{sub i}. Because Σ{sub micro} is independent of Σ{sub geo}, we propose they should be added quadratically, yielding for a combined GTV-to-PTV margin recipe: M{sub GTV-PTV} = √([aΣ{sub geo}]{sup 2} + [ƒ(N{sub i})Σ{sub micro}]{sup 2}) + bσ{sub geo}. This was validated by the computer model through numerous simultaneous simulations of microscopic and geometric uncertainties. Results: The margin factor ƒ(N{sub i}) in a relevant range of Σ{sub micro} and N{sub i} can be given by: ƒ(N{sub i}) = 1.4 + 0.8log(N{sub i}). Filling in the other factors found in our simulations (a = 2.1 and b = 0.8) yields for the combined recipe: M{sub GTV-PTV} = √((2.1Σ{sub geo}){sup 2} + ([1.4 + 0.8log(N{sub i})] × Σ{sub micro}){sup 2}) + 0.8σ{sub geo}. The average margin difference between the simultaneous simulations and the above recipe was 0.2 ± 0.8 mm (1 SD). Calculating M{sub geo} and M{sub micro} separately and adding them linearly overestimated PTVs by on

  1. Remedial Investigation concept plan for Picatinny Arsenal: Volume 2, Descriptions of and sampling plans for Remedial Investigation Sites

    SciTech Connect

    Benioff, P.A.; Bhattacharyya, M.H.; Biang, C.; Chiu, S.Y.; Miller, S.; Patton, T.; Pearl, R.; Yonk, A.; Yuen, C.R. )

    1991-03-01

    Argonne National Laboratory has prepared a Remedial Investigation (RI) Concept Plan for Picatinny Arsenal in New Jersey. Based on types of activity and location, the 156 RI Sites identified during the study are grouped into 16 Areas. The plan assesses the environmental status and identifies additional data needed for each RI Site in each Area. The plan was developed to comply with state and federal hazardous waste and water quality regulations. The plan also provides a ranking of the 16 Areas according to their potential for impacts on public health and the environment. Volume 2 describes the history, geology and hydrology, existing contamination, closure plan (if any), and proposed RI plan for each Site within each Area. 102 refs., 178 figs., 74 tabs.

  2. Space Station Mission Planning System (MPS) development study. Volume 2

    NASA Technical Reports Server (NTRS)

    Klus, W. J.

    1987-01-01

    The process and existing software used for Spacelab payload mission planning were studied. A complete baseline definition of the Spacelab payload mission planning process was established, along with a definition of existing software capabilities for potential extrapolation to the Space Station. This information was used as a basis for defining system requirements to support Space Station mission planning. The Space Station mission planning concept was reviewed for the purpose of identifying areas where artificial intelligence concepts might offer substantially improved capability. Three specific artificial intelligence concepts were to be investigated for applicability: natural language interfaces; expert systems; and automatic programming. The advantages and disadvantages of interfacing an artificial intelligence language with existing FORTRAN programs or of converting totally to a new programming language were identified.

  3. Orbiting deep space relay station. Volume 3: Implementation plan

    NASA Technical Reports Server (NTRS)

    Hunter, J. A.

    1979-01-01

    An implementation plan for the Orbiting Deep Space Relay Station (ODSRS) is described. A comparison of ODSRS life cycle costs to other configuration options meeting future communication requirements is presented.

  4. Proposed Site Treatment Plan (PSTP). Volumes 1 and 2 and Reference Document

    SciTech Connect

    Helmich, E.; Noller, D.K.; Wierzbicki, K.S.; Bailey, L.L.

    1994-12-22

    The Compliance Plan Volume provides overall schedules with target dates for achieving compliance with the land disposal restrictions (LDR) and contains procedures to establish milestones to be enforced under the Order. Information regarding the technical evaluation of treatment options for SRS mixed wastes is contained in the Background Volume and is provided for informational purposes only.

  5. The Follow Through Planned Variation Experiment; Volume V. Appendix: Analysis of Interim Follow Through Evaluation Reports.

    ERIC Educational Resources Information Center

    Villaume, John; Haney, Walt

    This report is the appendix to the last volume in a five volume series on the national evaluation study of the Follow Through Planned Variation Model. The appendix is organized in three sections. Section I provides detailed summaries of five major national Follow Through evaluation reports not published as part of this series. Section II is an…

  6. The National Manpower Survey of the Criminal Justice System. Volume Six: Criminal Justice Manpower Planning.

    ERIC Educational Resources Information Center

    National Planning Association, Washington, DC.

    Focusing on data needs and methods for manpower planning and manpower projections, this document is one in a series of six volumes reporting the results of the National Manpower Survey (NMS) of the Criminal Justice System. Chapter 1 of five chapters discusses the role and objectives of criminal justice manpower planning at different levels of…

  7. Community College Journal for Research and Planning, Volume VI, Numbers 1 and 2.

    ERIC Educational Resources Information Center

    Carter, Edith H., Ed.

    1988-01-01

    Designed as a forum for the exchange of information among members of the National Council for Research and Planning (NCRP), this journal provides articles on various aspects of community college research, management, and planning. The two issues of volume 6 contain the following articles: (1) "The President's Forum: What Have We Accomplished?" by…

  8. Engineering task plan for AX-104 residual waste volume and inventory data collection

    SciTech Connect

    Boechler, G.N., Fluor Daniel Hanford

    1997-03-06

    The purpose of this Engineering Task Plan is to document the strategy, equipment and responsibilities of the tasks required to preform the volume and inventory data collection of tank AX-104. The project is a part of the Hanford Tanks Initiative Plan document number WHC-SD-WM-PMP-022 Revision D.

  9. Preparing for the Future of the Workplace. Volume III: Planning Materials for Educators.

    ERIC Educational Resources Information Center

    Markley, O. W., Ed.

    This volume is the third of three reporting research that is intended to help postsecondary occupational education deans and directors become able to plan more strategically for using new instructional technologies to meet emerging needs. "Planning to Use Emerging Instructional Technologies: Some Useful Methods and Guidelines" (O. W.…

  10. 40 CFR Appendix D to Part 112 - Determination of a Worst Case Discharge Planning Volume

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .../or operated in such a manner that the multiple tanks function as one storage unit (i.e., multiple... plan that tanks with common piping or piping systems are not operated as one unit. If such evidence is... tanks that function as one oil storage unit, the worst case discharge planning volume would be based...

  11. 40 CFR Appendix D to Part 112 - Determination of a Worst Case Discharge Planning Volume

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .../or operated in such a manner that the multiple tanks function as one storage unit (i.e., multiple... plan that tanks with common piping or piping systems are not operated as one unit. If such evidence is... tanks that function as one oil storage unit, the worst case discharge planning volume would be based...

  12. 40 CFR Appendix D to Part 112 - Determination of a Worst Case Discharge Planning Volume

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .../or operated in such a manner that the multiple tanks function as one storage unit (i.e., multiple... plan that tanks with common piping or piping systems are not operated as one unit. If such evidence is... tanks that function as one oil storage unit, the worst case discharge planning volume would be based...

  13. Community College Journal for Research and Planning, Volume VII, Numbers 1 and 2.

    ERIC Educational Resources Information Center

    Carter, Edith H., Ed.

    1990-01-01

    Providing a forum for the exchange of information among members of the National Council for Research and Planning, this refereed journal offers articles on various aspects of community college research, management, and planning. The two issues of volume 7 contain the following articles: (1) "Case Studies of Community College High Risk Students:…

  14. System Development of Estimated Figures of Volume Production Plan

    ERIC Educational Resources Information Center

    Brazhnikov, Maksim A.; Khorina, Irina V.; Minina, Yulia I.; Kolyasnikova, Lyudmila V.; Streltsov, Aleksey V.

    2016-01-01

    The relevance of this problem is primarily determined by a necessity of improving production efficiency in conditions of innovative development of the economy and implementation of Import Substitution Program. The purpose of the article is development of set of criteria and procedures for the comparative assessment of alternative volume production…

  15. Volume reduction philosophy and techniques in use or planned

    SciTech Connect

    Row, T.H.

    1984-01-01

    Siting and development of nuclear waste disposal facilities is an expensive task. In the private sector, such developments face siting and licensing issues, public intervention, and technology challenges. The United States Department of Energy (DOE) faces similar challenges in the management of waste generated by the research and production facilities. Volume reduction can be used to lengthen the service life of existing facilities. A wide variety of volume reduction techniques are applied to different waste forms. Compressible waste is compacted into drums, cardboard and metal boxes, and the loaded drums are supercompacted into smaller units. Large metallic items are size-reduced and melted for recycle or sent to shallow land burial. Anaerobic digestion is a process that can reduce cellulosic and animal wastes by 80%. Incinerators of all types have been investigated for application to nuclear wastes and a number of installations operate or are constructing units for low-level and transuranic solid and liquid combustibles. Technology may help solve many of the problems in volume reduction, but the human element also has an important part in solving the puzzle. Aggressive educational campaigns at two sites have proved very successful in reducing waste generation. This overview of volume reduction is intended to transfer the current information from many DOE facilities. 44 references, 85 figures, 5 tables.

  16. Buried Waste Integrated Demonstration commercialization actions plans. Volume 1

    SciTech Connect

    Kaupanger, R.M.; Glore, D.

    1994-04-01

    The Buried Waste Integrated Demonstration (BWID) is sponsored by US Department of Energy (DOE) Office of Technology Development. BWID supports the development and demonstration of a suite of technologies that when integrated with commercially available baseline technologies form a comprehensive system for the effective and efficient remediation of buried waste throughout the DOE complex. BWID evaluates, validates, and demonstrates technologies and transfers this information throughout DOE and private industry to support DOE. remediation planning and implementation activities. This report documents commercialization action plans for five technologies with near-term commercialization/ implementation potential as well as provides a status of commercial and academic partners for each technology.

  17. Federal Facilities Compliance Act, Draft Site Treatment Plan: Background Volume, Part 2, Volume 1

    SciTech Connect

    1994-08-31

    This Draft Site Treatment Plan was prepared by Ames Laboratory to meet the requirements of the Federal Facilities Compliance Act. Topics discussed include: purpose and scope of the plan; site history and mission; draft plant organization; waste minimization; waste characterization; preferred option selection process; technology for treating low-level radioactive wastes and TRU wastes; future generation of mixed waste streams; funding; and process for evaluating disposal issues in support of the site treatment plan.

  18. Neutral Site Planning Project, Final Report. Volume II: Neighborhood Profiles.

    ERIC Educational Resources Information Center

    Providence School Dept., RI.

    As part of a plan for the development of neutral site magnet schools in Providence, twenty-four individual neighborhoods are profiled in a series of charts and tables which provide demographic, economic, housing, and social service and crime data. The information provided includes ethnic composition, age breakdowns, educational level, income,…

  19. Learner-Centered Instruction (LCI). Volume 3. Plan of Instruction.

    ERIC Educational Resources Information Center

    Pieper, William J.; And Others

    A plan of instruction (POI) is presented for an experimental course to train flight line weapon control systems technicians for the F-111A. The POI is based on the job behavioral description of this technician's job prepared earlier. The two basic decisions establishing the character of the POI are the overall objective of producing graduates…

  20. Twenty Five Lesson Plans for Distributive Education. Volume 4.

    ERIC Educational Resources Information Center

    Bennett, Nora; And Others

    The teaching guide for distributive education, grade levels 11 and 12, was developed by distributive education majors at Delaware State College. It contains five lesson plans for each of the instructional areas of: (1) the functions of marketing and distribution, (2) fundamental skills, (3) product or service technology, (4) social skills and…

  1. Studies in Family Planning, Volume 2 Number 11.

    ERIC Educational Resources Information Center

    Population Council, New York, NY.

    This paper presents the findings of a study of K. C. Chan, Research Officer of the Family Planning Association of Hong Kong, whose purpose was to determine whether IUD retention rates could be increased by home visits to acceptors. Concern with this problem has mounted in many countries where the IUD is the main contraceptive method offered and…

  2. Studies in Family Planning, Volume 3, Number 1.

    ERIC Educational Resources Information Center

    Population Council, New York, NY.

    Presented in the principal article, "Planning, Starting, and Operating an Educational Incentives Project," is a summary of activities to date in an educational savings project in Taiwan. The incentive project is designed to reward those couples who limit their family size, by providing funds for their children's secondary and higher education. To…

  3. Planning Educational Change. Volume 3: Integrating the Desegregated School.

    ERIC Educational Resources Information Center

    Chesler, Mark; And Others

    This manual has been designed to assist teachers and principals to achieve integrated schools, primary attention being focused on the problems of racial integration--the issues between blacks and whites in the schools. Chapters deal with the following: the meaning of integration and of planning for school change, delineating a six-stage scheme for…

  4. High Performance Schools Best Practices Manual. Volume I: Planning [and] Volume II: Design [and] Volume III: Criteria.

    ERIC Educational Resources Information Center

    Eley, Charles, Ed.

    This three-volume manual, focusing on California's K-12 public schools, presents guidelines for establishing schools that are healthy, comfortable, energy efficient, resource efficient, water efficient, secure, adaptable, and easy to operate and maintain. The first volume describes why high performance schools are important, what components are…

  5. Solar System Exploration Division Strategic Plan, volume 1. Executive summary and overview

    NASA Technical Reports Server (NTRS)

    1991-01-01

    This first document is the first of a six-volume series presenting the Solar System Exploration Division's Strategic Plan for the 10-year period FY 1994 to FY 2003. The overall strategy is characterized by five fundamental precepts: (1) execute the current program; (2) improve the vitality of the program and the planetary science community; (3) initiate innovative, small, low-cost planetary missions; (4) initiate new major and moderate missions; and (5) prepare for the next generation of missions. This Strategic Plan describes in detail our proposed approach to accomplish these goals. Volume 1 provides first an Executive Summary of highlights of each of the six volumes, and then goes on to present an overview of the plan, including a discussion of the planning context and strategic approach. Volumes 2, 3, 4, and 5 describe in detail the initiatives proposed. An integral part of each of these volumes is a set of responses to the mission selection criteria questions developed by the Space and Earth Science Advisory Committee. Volume 2, Mission From Planet Earth, describes a strategy for exploring the Moon and Mars and sets forth proposed moderate missions--Lunar Observer and a Mars lander network. Volume 3, Pluto Flyby/Neptune Orbiter, discusses our proposed major new start candidate for the FY 1994 to FY 1998 time frame. Volume 4, Discovery, describes the Near-Earth Asteroid Rendezvous, as well as other candidates for this program of low-cost planetary missions. Volume 5, Toward Other Planetary Systems, describes a major research and analysis augmentation that focuses on extrasolar planet detection and the study of planetary system processes. Finally, Volume 6 summarizes the technology program that the division has structured around these four initiatives.

  6. Guidelines for Analysis of Health Manpower Planning. Volume 3: Health Manpower Planning. International Health Planning Methods Series.

    ERIC Educational Resources Information Center

    Staff, Robert J.; Porter, Dennis R.

    Intended to assist Agency for International Development (AID) officers, advisors, and health officials in incorporating health planning into national plans for economic development, this third of ten manuals in the International Health Planning Methods Series deals with health manpower planning and assessment. It provides a conceptual and…

  7. Guidelines for Analysis of Environmental Health Planning in Developing Countries. Volume 2: Environmental Health Planning. International Health Planning Methods Series.

    ERIC Educational Resources Information Center

    Fraser, Renee White; Shani, Hadasa

    Intended to assist Agency for International Development (AID) officers, advisors, and health officials in incorporating health planning into national plans for economic development, this second of ten manuals in the International Health Planning Methods Series deals with assessment, planning, and evaluation in the field of environmental health.…

  8. Guidelines for Analysis of Environmental Health Planning in Developing Countries. Volume 2: Environmental Health Planning. International Health Planning Methods Series.

    ERIC Educational Resources Information Center

    Fraser, Renee White; Shani, Hadasa

    Intended to assist Agency for International Development (AID) officers, advisors, and health officials in incorporating health planning into national plans for economic development, this second of ten manuals in the International Health Planning Methods Series deals with assessment, planning, and evaluation in the field of environmental health.…

  9. In-space propellant logistics. Volume 4: Project planning data

    NASA Technical Reports Server (NTRS)

    1972-01-01

    The prephase A conceptual project planning data as it pertains to the development of the selected logistics module configuration transported into earth orbit by the space shuttle orbiter. The data represents the test, implementation, and supporting research and technology requirements for attaining the propellant transfer operational capability for early 1985. The plan is based on a propellant module designed to support the space-based tug with cryogenic oxygen-hydrogen propellants. A logical sequence of activities that is required to define, design, develop, fabricate, test, launch, and flight test the propellant logistics module is described. Included are the facility and ground support equipment requirements. The schedule of activities are based on the evolution and relationship between the R and T, the development issues, and the resultant test program.

  10. Formulation of consumables management models. Volume 1: Mission planning

    NASA Technical Reports Server (NTRS)

    Torian, J. G.; Zamora, M. A.

    1978-01-01

    Development of an STS (Space Transportation System) interactive computer program MPP (Mission Planning Processor) working model was conducted. A summary of the computer program development and those supporting tasks conducted is presented. Development of the MPP Computer Program is discussed. This development was supported by several parallel tasks. These tasks either directly supported the program development, or provided information for future application and/or modification to the program in relation to the flight planning and flight operations of the STS and advanced spacecraft. The supporting tasks also included development of a Space Station MPP to demonstrate the applicability of the analytical methods developed under this RTOP to more advanced spacecraft than the STS.

  11. Space physics strategy: Implementation study. Volume 2: Program plan

    NASA Technical Reports Server (NTRS)

    1991-01-01

    In June, 1989, the Space Science and Applications Advisory Committee (SSAAC) authorized its Space Physics Subcommittee (SPS) to prepare a plan specifying the future missions, launch sequence, and encompassing themes of the Space Physics Division. The plan, now complete, is the product of a year-long study comprising two week-long workshops - in January and June 1990 - assisted by pre-workshop, inter-workshop, and post-workshop preparation and assessment activities. The workshops engaged about seventy participants, drawn equally from the Division's four science disciplines: cosmic and heliospheric physics, solar physics, magnetosphere physics, and ionosphere-thermosphere-mesospheric physics. An earlier report records the outcome of the first workshop; this is the report of the final workshop.

  12. C3I Analysis Tools for Development Planning. Volume 1

    DTIC Science & Technology

    1985-09-27

    modeling method was developed for use in Command, Control Communications and Intelligence (C ) systems planning and evaluation. Model is based on...algrebraic relationship for each node of a tree structure which describes decision process in command and control systems for strategic and ballistic...SECURITY CLASSIFICATION OF THIS PAGE Unclassified SECURITY CLASSIFICATION OF THIS PAGE Cont of Block 18: 3 C I Command, Control , Communications

  13. Developing and Testing Simulated Occupational Experiences for Distributive Education Students in Rural Communities: Volume III: Training Plans: Final Report.

    ERIC Educational Resources Information Center

    Virginia Polytechnic Inst. and State Univ., Blacksburg.

    Volume 3 of a three volume final report presents prototype job training plans developed as part of a research project which pilot tested a distributive education program for rural schools utilizing a retail store simulation plan. The plans are for 15 entry-level and 15 career-level jobs in seven categories of distributive business (department…

  14. General Urban Warfare Amphibious Logistics Applications. Volume 2. Operations Plan.

    DTIC Science & Technology

    1983-06-23

    Appendix 7 (Engineer Support Plan). Estimated Priority Bridae Task Size Unit Assigned 1 1, 3, 5 Co.(-) 7th Engr Spt Bn 2 6, 7, 8, 10 Pit.(+) 7th Engr Spt... BrIda OtnarAl U. S149Ay Cr ogS~y~po~m B~n. I ~litrhotlnl OC-400n0la 14 i l IA cvV (DAREEP IV03R2 I F IUIVTGNEA W UNCLASIFIE IgdirGo ,1 VA .CM Marf tf

  15. Integrated payload and mission planning, phase 3. Volume 1: Integrated payload and mission planning process evaluation

    NASA Technical Reports Server (NTRS)

    Sapp, T. P.; Davin, D. E.

    1977-01-01

    The integrated payload and mission planning process for STS payloads was defined, and discrete tasks which evaluate performance and support initial implementation of this process were conducted. The scope of activity was limited to NASA and NASA-related payload missions only. The integrated payload and mission planning process was defined in detail, including all related interfaces and scheduling requirements. Related to the payload mission planning process, a methodology for assessing early Spacelab mission manager assignment schedules was defined.

  16. SeaWiFS calibration and validation plan, volume 3

    NASA Technical Reports Server (NTRS)

    Hooker, Stanford B. (Editor); Firestone, Elaine R. (Editor); Mcclain, Charles R.; Esaias, Wayne E.; Barnes, William; Guenther, Bruce; Endres, Daniel; Mitchell, B. Greg; Barnes, Robert

    1992-01-01

    The Sea-viewing Wide Field-of-view Sensor (SeaWiFS) will be the first ocean-color satellite since the Nimbus-7 Coastal Zone Color Scanner (CZCS), which ceased operation in 1986. Unlike the CZCS, which was designed as a proof-of-concept experiment, SeaWiFS will provide routine global coverage every 2 days and is designed to provide estimates of photosynthetic concentrations of sufficient accuracy for use in quantitative studies of the ocean's primary productivity and biogeochemistry. A review of the CZCS mission is included that describes that data set's limitations and provides justification for a comprehensive SeaWiFS calibration and validation program. To accomplish the SeaWiFS scientific objectives, the sensor's calibration must be constantly monitored, and robust atmospheric corrections and bio-optical algorithms must be developed. The plan incorporates a multi-faceted approach to sensor calibration using a combination of vicarious (based on in situ observations) and onboard calibration techniques. Because of budget constraints and the limited availability of ship resources, the development of the operational algorithms (atmospheric and bio-optical) will rely heavily on collaborations with the Earth Observing System (EOS), the Moderate Resolution Imaging Spectrometer (MODIS) oceans team, and projects sponsored by other agencies, e.g., the U.S. Navy and the National Science Foundation (NSF). Other elements of the plan include the routine quality control of input ancillary data (e.g., surface wind, surface pressure, ozone concentration, etc.) used in the processing and verification of the level-0 (raw) data to level-1 (calibrated radiances), level-2 (derived products), and level-3 (gridded and averaged derived data) products.

  17. SeaWiFS calibration and validation plan, volume 3

    SciTech Connect

    Hooker, S.B.; Firestone, E.R.; Mcclain, C.R.; Esaias, W.E.; Barnes, W.; Guenther, B.; Endres, D.; Mitchell, B.G.; Barnes, R.

    1992-09-01

    The Sea-viewing Wide Field-of-view Sensor (SeaWiFS) will be the first ocean-color satellite since the Nimbus-7 Coastal Zone Color Scanner (CZCS), which ceased operation in 1986. Unlike the CZCS, which was designed as a proof-of-concept experiment, SeaWiFS will provide routine global coverage every 2 days and is designed to provide estimates of photosynthetic concentrations of sufficient accuracy for use in quantitative studies of the ocean's primary productivity and biogeochemistry. A review of the CZCS mission is included that describes that data set's limitations and provides justification for a comprehensive SeaWiFS calibration and validation program. To accomplish the SeaWiFS scientific objectives, the sensor's calibration must be constantly monitored, and robust atmospheric corrections and bio-optical algorithms must be developed. The plan incorporates a multi-faceted approach to sensor calibration using a combination of vicarious (based on in situ observations) and onboard calibration techniques. Because of budget constraints and the limited availability of ship resources, the development of the operational algorithms (atmospheric and bio-optical) will rely heavily on collaborations with the Earth Observing System (EOS), the Moderate Resolution Imaging Spectrometer (MODIS) oceans team, and projects sponsored by other agencies, e.g., the U.S. Navy and the National Science Foundation (NSF). Other elements of the plan include the routine quality control of input ancillary data (e.g., surface wind, surface pressure, ozone concentration, etc.) used in the processing and verification of the level-0 (raw) data to level-1 (calibrated radiances), level-2 (derived products), and level-3 (gridded and averaged derived data) products.

  18. Solid earth science in the 1990s. Volume 1: Program plan

    NASA Technical Reports Server (NTRS)

    1991-01-01

    This is volume one of a three volume series. A plan for solid earth science research for the next decade is outlined. The following topics are addressed: scientific requirements; status of current research; major new emphasis in the 1990's; interagency and international participation; and the program implementation plan. The following fields are represented: plate motion and deformation; lithospheric structure and evolution; volcanology; land surface (processes of change); earth structure and dynamics; earth rotation and reference frames; and geopotential fields. Other topics of discussion include remote sensing, space missions, and space techniques.

  19. Environmental Assessment, Wing Infrastructure Development Outlook (WINDO) Implementation Plan (FY 04-06). Volume 1, Beale Air Force Base, California

    DTIC Science & Technology

    2005-07-01

    Environmental Assessment Wing Infrastructure Development Outlook (WINDO) Implementation Plan (FY 04-06) Volume 1 Beale Air Force Base, California ...Development Outlook (WINDO) Implementation Plan (FY 04-06) Volume 1 Beale Air Force Base, California 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM...THE PROPOSED ACTION Wing Infrastructure Development Outlook (WINDO) Implementation Plan at Beale Air Force Base (AFB), California : Volume 1

  20. Space Station Mission Planning Study (MPS) development study. Volume 3: Software development plan

    NASA Technical Reports Server (NTRS)

    Klus, W. L.

    1987-01-01

    A software development plan is presented for the definition, design, and implementation of the Space Station (SS) Payload Mission Planning System (MPS). This plan is an evolving document and must be updated periodically as the SS design and operations concepts as well as the SS MPS concept evolve. The major segments of this plan are as follows: an overview of the SS MPS and a description of its required capabilities including the computer programs identified as configurable items with an explanation of the place and function of each within the system; an overview of the project plan and a detailed description of each development project activity breaking each into lower level tasks where applicable; identification of the resources required and recommendations for the manner in which they should be utilized including recommended schedules and estimated manpower requirements; and a description of the practices, standards, and techniques recommended for the SS MPS Software (SW) development.

  1. Split-volume treatment planning of multiple consecutive vertebral body metastases for cyberknife image-guided robotic radiosurgery.

    PubMed

    Sahgal, Arjun; Chuang, Cynthia; Larson, David; Huang, Kim; Petti, Paula; Weinstein, Phil; Ma, Lijun

    2008-01-01

    Cyberknife treatment planning of multiple consecutive vertebral body metastases is challenging due to large target volumes adjacent to critical normal tissues. A split-volume treatment planning technique was developed to improve the treatment plan quality of such lesions. Treatment plans were generated for 1 to 5 consecutive thoracic vertebral bodies (CVBM) prescribing a total dose of 24 Gy in 3 fractions. The planning target volume (PTV) consisted of the entire vertebral body(ies). Treatment plans were generated considering both the de novo clinical scenario (no prior radiation), imposing a dose limit of 8 Gy to 1 cc of spinal cord, and the retreatment scenario (prior radiation) with a dose limit of 3 Gy to 1 cc of spinal cord. The split-volume planning technique was compared with the standard full-volume technique only for targets ranging from 2 to 5 CVBM in length. The primary endpoint was to obtain best PTV coverage by the 24 Gy prescription isodose line. A total of 18 treatment plans were generated (10 standard and 8 split-volume). PTV coverage by the 24-Gy isodose line worsened consistently as the number of CVBM increased for both the de novo and retreatment scenario. Split-volume planning was achieved by introducing a 0.5-cm gap, splitting the standard full-volume PTV into 2 equal length PTVs. In every case, split-volume planning resulted in improved PTV coverage by the 24-Gy isodose line ranging from 4% to 12% for the de novo scenario and, 8% to 17% for the retreatment scenario. We did not observe a significant trend for increased monitor units required, or higher doses to spinal cord or esophagus, with split-volume planning. Split-volume treatment planning significantly improves Cyberknife treatment plan quality for CVBM, as compared to the standard technique. This technique may be of particular importance in clinical situations where stringent spinal cord dose limits are required.

  2. Split-Volume Treatment Planning of Multiple Consecutive Vertebral Body Metastases for Cyberknife Image-Guided Robotic Radiosurgery

    SciTech Connect

    Sahgal, Arjun Chuang, Cynthia; Larson, David; Huang, Kim; Petti, Paula; Weinstein, Phil; Ma Lijun

    2008-10-01

    Cyberknife treatment planning of multiple consecutive vertebral body metastases is challenging due to large target volumes adjacent to critical normal tissues. A split-volume treatment planning technique was developed to improve the treatment plan quality of such lesions. Treatment plans were generated for 1 to 5 consecutive thoracic vertebral bodies (CVBM) prescribing a total dose of 24 Gy in 3 fractions. The planning target volume (PTV) consisted of the entire vertebral body(ies). Treatment plans were generated considering both the de novo clinical scenario (no prior radiation), imposing a dose limit of 8 Gy to 1 cc of spinal cord, and the retreatment scenario (prior radiation) with a dose limit of 3 Gy to 1 cc of spinal cord. The split-volume planning technique was compared with the standard full-volume technique only for targets ranging from 2 to 5 CVBM in length. The primary endpoint was to obtain best PTV coverage by the 24 Gy prescription isodose line. A total of 18 treatment plans were generated (10 standard and 8 split-volume). PTV coverage by the 24-Gy isodose line worsened consistently as the number of CVBM increased for both the de novo and retreatment scenario. Split-volume planning was achieved by introducing a 0.5-cm gap, splitting the standard full-volume PTV into 2 equal length PTVs. In every case, split-volume planning resulted in improved PTV coverage by the 24-Gy isodose line ranging from 4% to 12% for the de novo scenario and, 8% to 17% for the retreatment scenario. We did not observe a significant trend for increased monitor units required, or higher doses to spinal cord or esophagus, with split-volume planning. Split-volume treatment planning significantly improves Cyberknife treatment plan quality for CVBM, as compared to the standard technique. This technique may be of particular importance in clinical situations where stringent spinal cord dose limits are required.

  3. Beam-specific planning volumes for scattered-proton lung radiotherapy

    NASA Astrophysics Data System (ADS)

    Flampouri, S.; Hoppe, B. S.; Slopsema, R. L.; Li, Z.

    2014-08-01

    This work describes the clinical implementation of a beam-specific planning treatment volume (bsPTV) calculation for lung cancer proton therapy and its integration into the treatment planning process. Uncertainties incorporated in the calculation of the bsPTV included setup errors, machine delivery variability, breathing effects, inherent proton range uncertainties and combinations of the above. Margins were added for translational and rotational setup errors and breathing motion variability during the course of treatment as well as for their effect on proton range of each treatment field. The effect of breathing motion and deformation on the proton range was calculated from 4D computed tomography data. Range uncertainties were considered taking into account the individual voxel HU uncertainty along each proton beamlet. Beam-specific treatment volumes generated for 12 patients were used: a) as planning targets, b) for routine plan evaluation, c) to aid beam angle selection and d) to create beam-specific margins for organs at risk to insure sparing. The alternative planning technique based on the bsPTVs produced similar target coverage as the conventional proton plans while better sparing the surrounding tissues. Conventional proton plans were evaluated by comparing the dose distributions per beam with the corresponding bsPTV. The bsPTV volume as a function of beam angle revealed some unexpected sources of uncertainty and could help the planner choose more robust beams. Beam-specific planning volume for the spinal cord was used for dose distribution shaping to ensure organ sparing laterally and distally to the beam.

  4. Beam-specific planning volumes for scattered-proton lung radiotherapy.

    PubMed

    Flampouri, S; Hoppe, B S; Slopsema, R L; Li, Z

    2014-08-21

    This work describes the clinical implementation of a beam-specific planning treatment volume (bsPTV) calculation for lung cancer proton therapy and its integration into the treatment planning process. Uncertainties incorporated in the calculation of the bsPTV included setup errors, machine delivery variability, breathing effects, inherent proton range uncertainties and combinations of the above. Margins were added for translational and rotational setup errors and breathing motion variability during the course of treatment as well as for their effect on proton range of each treatment field. The effect of breathing motion and deformation on the proton range was calculated from 4D computed tomography data. Range uncertainties were considered taking into account the individual voxel HU uncertainty along each proton beamlet. Beam-specific treatment volumes generated for 12 patients were used: a) as planning targets, b) for routine plan evaluation, c) to aid beam angle selection and d) to create beam-specific margins for organs at risk to insure sparing. The alternative planning technique based on the bsPTVs produced similar target coverage as the conventional proton plans while better sparing the surrounding tissues. Conventional proton plans were evaluated by comparing the dose distributions per beam with the corresponding bsPTV. The bsPTV volume as a function of beam angle revealed some unexpected sources of uncertainty and could help the planner choose more robust beams. Beam-specific planning volume for the spinal cord was used for dose distribution shaping to ensure organ sparing laterally and distally to the beam.

  5. A method to individualize adaptive planning target volumes for deformable targets

    NASA Astrophysics Data System (ADS)

    Wright, Pauliina; Redpath, Anthony Thomas; Høyer, Morten; Muren, Ludvig Paul

    2009-12-01

    We have investigated a method to individualize the planning target volume (PTV) for deformable targets in radiotherapy by combining a computer tomography (CT) scan with multiple cone beam (CB)CT scans. All combinations of the CT and up to five initial CBCTs were considered. To exclude translational motion, the clinical target volumes (CTVs) in the CBCTs were matched to the CTV in the CT. PTVs investigated were the unions, the intersections and all other structures defined by a volume with a constant CTV location frequency. The method was investigated for three bladder cancer patients with a CT and 20-27 CBCTs. Reliable alternatives to a standard PTV required use of at least four scans for planning. The CTV unions of four or five scans gave similar results when considering the fraction of individual repeat scan CTVs they volumetrically covered to at least 99%. For patient 1, 64% of the repeat scan CTVs were covered by these unions and for patient 2, 86% were covered. Further, the PTVs defined by the volume occupied by the CTV in all except one of the four or five planning scans seemed clinically feasible. On average, 52% of the repeat CBCT CTVs for patient 1 and 64% for patient 2 were covered to minimum 99% of their total volume. For patient 3, the method failed due to poor volume control of the bladder. The suggested PTVs could, with considerably improved conformity, complement the standard PTV.

  6. Lymphatic atlas-based target volume definition for intensity-modulated radiation therapy planning

    NASA Astrophysics Data System (ADS)

    Qatarneh, S. M.; Kiricuta, I. C.; Brahme, A.; Noz, M. E.; Ferreira, B.; Kim, W. C.; Lind, B. K.

    2007-10-01

    Despite the improvements in current imaging modalities such as CT and MRI, the detection of normal or malignant lymph nodes remains a challenge due to the large variability in lymph node characteristics and the variation in imaging quality and the limited imaging resolution. A computerized lymph node atlas could be the ideal tool for target volume definition based on the distribution of normal lymph nodes surrounding the verified malignant nodes to improve the accuracy of intensity-modulated radiation therapy planning. The standard lymph node topography in the newly constructed 3D lymph node atlas offers a detailed topographical distribution of discrete nodal locations in relation to surrounding organs at risk. In the present paper, the recently developed lymph node atlas is used for selection and delineation of target volumes in the head and neck, thorax and pelvic region. Image registration techniques were implemented to integrate the topography of the lymph node atlas into the patient's data set. By combining the knowledge-based lymph node distribution with the patient's data set, more detailed definitions of the target volumes were obtained to facilitate biologically based treatment plan optimization. The response values of the biologically optimized treatment plans were used to derive the probability of tumor control and the probability of complications in organs at risk. The treatment outcome of the lung reference plan showed a lower probability of recurrence in comparison to planning without the lymph node atlas. The lymph node atlas can improve and standardize the target volume definition by including more accurate anatomical knowledge for target volume definition and biologically optimized radiation therapy planning.

  7. The Federal Aviation Administration Plan for Research, Engineering and Development. Volume 1. Program Plan

    DTIC Science & Technology

    1989-01-01

    the FAA to deal with the numbers of new carriers and aircraft seeking to use the aviation system. New approaches are needed to meet growing demands...One approach may be the creation of an FAA RE&D Advisory Committee. This committee would provide the FAA administrator with advice and recommendations...systems approach . The plan represents an evolving FAA response to an ever-changing aviation environment; though 90 percent of the original NAS F&E Plan

  8. Monte Carlo Simulations for Dosimetry in Prostate Radiotherapy with Different Intravesical Volumes and Planning Target Volume Margins

    PubMed Central

    Lv, Wei; Yu, Dong; He, Hengda; Liu, Qian

    2016-01-01

    In prostate radiotherapy, the influence of bladder volume variation on the dose absorbed by the target volume and organs at risk is significant and difficult to predict. In addition, the resolution of a typical medical image is insufficient for visualizing the bladder wall, which makes it more difficult to precisely evaluate the dose to the bladder wall. This simulation study aimed to quantitatively investigate the relationship between the dose received by organs at risk and the intravesical volume in prostate radiotherapy. The high-resolution Visible Chinese Human phantom and the finite element method were used to construct 10 pelvic models with specific intravesical volumes ranging from 100 ml to 700 ml to represent bladders of patients with different bladder filling capacities during radiotherapy. This series of models was utilized in six-field coplanar 3D conformal radiotherapy simulations with different planning target volume (PTV) margins. Each organ’s absorbed dose was calculated using the Monte Carlo method. The obtained bladder wall displacements during bladder filling were consistent with reported clinical measurements. The radiotherapy simulation revealed a linear relationship between the dose to non-targeted organs and the intravesical volume and indicated that a 10-mm PTV margin for a large bladder and a 5-mm PTV margin for a small bladder reduce the effective dose to the bladder wall to similar degrees. However, larger bladders were associated with evident protection of the intestines. Detailed dosimetry results can be used by radiation oncologists to create more accurate, individual water preload protocols according to the patient’s anatomy and bladder capacity. PMID:27441944

  9. 40 CFR Appendix D to Part 112 - Determination of a Worst Case Discharge Planning Volume

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Determination of a Worst Case Discharge Planning Volume D Appendix D to Part 112 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... determined by the RA that the facility could cause substantial harm to the environment. The calculation of a...

  10. Methodological Approaches for Determining Health Manpower Supply and Requirements. Volume II. Practical Planning Manual.

    ERIC Educational Resources Information Center

    Kriesberg, Harriet M.; And Others

    This second of a two-volume monograph, which describes and evaluates various methods used to determine present and future health manpower supply and requirements, is intended to contribute to planners' understanding of the state of the art and to the improvement of health manpower planning. The methodologies presented, chosen after a review of the…

  11. 40 CFR Appendix D to Part 112 - Determination of a Worst Case Discharge Planning Volume

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Determination of a Worst Case Discharge Planning Volume D Appendix D to Part 112 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS OIL POLLUTION PREVENTION Pt. 112, App. D Appendix D to Part 112—Determination of...

  12. Teaching East Asia: China, Japan, Korea. Lesson Plans for Middle School Teachers. Volume II.

    ERIC Educational Resources Information Center

    Beville, Francie; Boone, Mark; Chapman, Kelly; Crump, Claudia; Curtis, Lonnie; Erickson, Stacy; Kaiser-Polge, Tami; Klus, John A.; Luebbehusen, Mary Lou; Rea, Patrick S.; Ward, Mary E.

    This volume contains 23 lesson plans that were written for middle school teachers to help students learn about East Asia. The lessons are organized across six themes: (1) "People, Places & Environment"; (2) "Technology, Production, Distribution & Consumption"; (3) "Cultures, Continuity, and Change"; (4)…

  13. Plans for crash-tested bridge railings for longitudinal wood decks on low-volume roads

    Treesearch

    Michael A. Ritter; Ronald K. Faller; Steve. Bunnell; Paula D. Hilbrich Lee; Barry T. Rosson

    1998-01-01

    The plans for crashworthy bridge railings for low-volume roads were developed through a cooperative research program involving the USDA Forest Service, Forest Products Laboratory (FPL); the Midwest Roadside Safety Facility, University of Nebraska-Lincoln (MwRSF); and the Forest Service, National Forest System, Engineering. Three railings were developed and successfully...

  14. Teaching East Asia: China, Japan, Korea. Lesson Plans for Middle School Teachers. Volume I.

    ERIC Educational Resources Information Center

    Aiken, Geoff; Benton, Susan; Duvall, James; Eltzroth, Diane; Hooyberg, Astrid; Keim, Marilee; Norris, Elizabeth; Smith, Peggy; Vogel, Kathy; Williams, Steven

    This volume contains 40 lesson plans that were written for middle school teachers to help students learn about East Asia. The lessons are organized across five themes: (1) "People, Places & Environment"; (2) "Technology, Production, Distribution & Consumption"; (3) "Cultures, Continuity, Change"; (4)…

  15. Savannah River Site Environmental Monitoring Plan. Volume 1, Section 1000 Addendum: Revision 3

    SciTech Connect

    Jannik, G.T.

    1994-10-01

    This document -- the Savannah River Site Environmental Monitoring Plan (SRS EM Plan) -- has been prepared according to guidance contained in the DOE 5400 Series orders, in 10 CFR 834, and in DOE/EH-0173T, Environmental Regulatory Guide for Radiological Effluent Monitoring and environmental Surveillance [DOE, 1991]. The SRS EM Plan`s purpose is to define the criteria, regulations, and guideline requirements with which SRS will comply. These criteria and requirements are applicable to environmental monitoring activities performed in support of the SRS Environmental Monitoring Program (SRS EM Program), WSRC-3Q1-2, Volume 1, Section 1100. They are not applicable to monitoring activities utilized exclusively for process monitoring/control. The environmental monitoring program requirements documented in the SRS EM Plan incorporate all applicable should requirements of DOE/EH-0173T and expand upon them to include nonradiological environmental monitoring program requirements.

  16. Cassini atmospheric chemistry mapper. Volume 1. Investigation and technical plan

    NASA Technical Reports Server (NTRS)

    Smith, William Hayden; Baines, Kevin Hays; Drossart, Pierre; Fegley, Bruce; Orton, Glenn; Noll, Keith; Reitsema, Harold; Bjoraker, Gordon L.

    1990-01-01

    The Cassini Atmospheric Chemistry Mapper (ACM) enables a broad range of atmospheric science investigations for Saturn and Titan by providing high spectral and spatial resolution mapping and occultation capabilities at 3 and 5 microns. ACM can directly address the major atmospheric science objectives for Saturn and for Titan, as defined by the Announcement of Opportunity, with pivotal diagnostic measurements not accessible to any other proposed Cassini instrument. ACM determines mixing ratios for atmospheric molecules from spectral line profiles for an important and extensive volume of the atmosphere of Saturn (and Jupiter). Spatial and vertical profiles of disequilibrium species abundances define Saturn's deep atmosphere, its chemistry, and its vertical transport phenomena. ACM spectral maps provide a unique means to interpret atmospheric conditions in the deep (approximately 1000 bar) atmosphere of Saturn. Deep chemistry and vertical transport is inferred from the vertical and horizontal distribution of a series of disequilibrium species. Solar occultations provide a method to bridge the altitude range in Saturn's (and Titan's) atmosphere that is not accessible to radio science, thermal infrared, and UV spectroscopy with temperature measurements to plus or minus 2K from the analysis of molecular line ratios and to attain an high sensitivity for low-abundance chemical species in the very large column densities that may be achieved during occultations for Saturn. For Titan, ACM solar occultations yield very well resolved (1/6 scale height) vertical mixing ratios column abundances for atmospheric molecular constituents. Occultations also provide for detecting abundant species very high in the upper atmosphere, while at greater depths, detecting the isotopes of C and O, constraining the production mechanisms, and/or sources for the above species. ACM measures the vertical and horizontal distribution of aerosols via their opacity at 3 microns and, particularly, at 5

  17. [Definition of accurate planning target volume margins for esophageal cancer radiotherapy].

    PubMed

    Lesueur, P; Servagi-Vernat, S

    2016-10-01

    More than 4000 cases of esophagus neoplasms are diagnosed every year in France. Radiotherapy, which can be delivered in preoperative or exclusive with a concomitant chemotherapy, plays a central role in treatment of esophagus cancer. Even if efficacy of radiotherapy no longer has to be proved, the prognosis of esophagus cancer remains unfortunately poor with a high recurrence rate. Toxicity of esophageal radiotherapy is correlated with the irradiation volume, and limits dose escalation and local control. Esophagus is a deep thoracic organ, which undergoes cardiac and respiratory motion, making the radiotherapy delivery more difficult and increasing the planning target volume margins. Definition of accurate planning target volume margins, taking into account the esophagus' intrafraction motion and set up margins is very important to be sure to cover the clinical target volume and restrains acute and late radiotoxicity. In this article, based on a review of the literature, we propose planning target volume margins adapted to esophageal radiotherapy. Copyright © 2016 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.

  18. The spill prevention, control, and countermeasures (SPCC) plan for the Y-12 Plant. Volume 1

    SciTech Connect

    Not Available

    1992-08-01

    This spill prevention, control and countermeasures (SPCC) Plan is divided into two volumes. Volume I addresses Y-12`s compliance with regulations pertinent to the content of SPCC Plans. Volume II is the SPCC Hazardous Material Storage Data Base, a detailed tabulation of facility-specific information and data on potential spill sources at the Y-12 Plant. Volume I follows the basic format and subject sequence specified in 40 CFR 112.7. This sequence is prefaced by three additional chapters, including this introduction and brief discussions of the Y-12 Plant`s background/environmental setting and potential spill source categories. Two additional chapters on containers and container storage areas and PCB and PCB storage for disposal facilities are inserted into the required sequence. The following required subjects are covered in this volume: Spill history, site drainage; secondary containment/diversion structures and equipment; contingency plans; notification and spill response procedures; facility drainage; bulk storage tanks; facility transfer operations, pumping, and in-plant processes; transfer stations (facility tank cars/tank tracks); inspections and records; security, and personnel, training, and spill prevention procedures.

  19. A Five-Year Plan for Meeting the Automatic Data Processing and Telecommunications Needs of the Federal Government. Volume l: Planning Strategies.

    ERIC Educational Resources Information Center

    Department of Commerce, Washington, DC.

    The first of two volumes, this document describes the planning process of a 5-year plan for meeting the telecommunications and automatic data processing (ADP) needs of the federal government, examines the planning efforts of several typical agencies, and explores issues involved in managing new technology as it evolves. For each agency,…

  20. Phase C/D program development plan. Volume 1: Program plan

    NASA Technical Reports Server (NTRS)

    1971-01-01

    The Phase C/D definition of the Modular Space Station has been developed. The modular approach selected during the option period was evaluated, requirements were defined, and program definition and preliminary design were accomplished. The Space Station Project is covered in depth, the research applications module is limited to a project-level definition, and the shuttle operations are included for interface requirements identification, scheduling, and costing. Discussed in detail are: (1) baseline program and project descriptions; (2) phase project planning; (3) modular space station program schedule; (4) program management plan; (5) operations; (6) facilities; (7) logistics; and (8) manpower.

  1. Geometry of volumes in radiotherapy planning. A new method for a quantitative assessment.

    PubMed

    Tomatis, Stefano; Carrara, Mauro; Massafra, Elisa; Naldi, Giovanni; Palazzi, Mauro; Orlandi, Ester; Marchesini, Renato

    2011-01-01

    The purpose of the study was to develop a general method able to quantify the mutual disposition in the 3D space of critical organs with respect to the target when these structures are designed for a radiotherapy treatment plan. To that end, we introduce the "expansion intersection histogram", a function defined as the intersection between an organ at risk and the target volume, while the target is expanded in 3D. A software was developed to calculate the expansion intersection histogram of anatomical structures exported in a DICOM format from a commercial treatment planning system. A virtual phantom with spherical and cylindrical objects arranged in different dispositions in the 3D space was created for testing the software under known conditions. Expansion intersection histogram computation was tested against reference data derived analytically for spherical volumes, with a resulting maximum error of 0.5%. Specific geometric features derived from the expansion intersection histogram, such as the distance between a selected target and each different ideal volume included in the virtual phantom, well matched the corresponding theoretical expected values. The expansion intersection histogram was evaluated also for the anatomical structures of a real patient. Data show this method as a tool to effectively take into account the mutual disposition of each critical organ with respect to the target, summarized in characteristics of distance, shape and orientation. The expansion intersection histogram method integrates and extends other preexisting modalities for evaluating the geometrical relationships among radiotherapy volumes and could be used to improve planning optimization.

  2. Data fusion for planning target volume and isodose prediction in prostate brachytherapy

    NASA Astrophysics Data System (ADS)

    Nouranian, Saman; Ramezani, Mahdi; Mahdavi, S. Sara; Spadinger, Ingrid; Morris, William J.; Salcudean, Septimiu E.; Abolmaesumi, Purang

    2015-03-01

    In low-dose prostate brachytherapy treatment, a large number of radioactive seeds is implanted in and adjacent to the prostate gland. Planning of this treatment involves the determination of a Planning Target Volume (PTV), followed by defining the optimal number of seeds, needles and their coordinates for implantation. The two major planning tasks, i.e. PTV determination and seed definition, are associated with inter- and intra-expert variability. Moreover, since these two steps are performed in sequence, the variability is accumulated in the overall treatment plan. In this paper, we introduce a model based on a data fusion technique that enables joint determination of PTV and the minimum Prescribed Isodose (mPD) map. The model captures the correlation between different information modalities consisting of transrectal ultrasound (TRUS) volumes, PTV and isodose contours. We take advantage of joint Independent Component Analysis (jICA) as a linear decomposition technique to obtain a set of joint components that optimally describe such correlation. We perform a component stability analysis to generate a model with stable parameters that predicts the PTV and isodose contours solely based on a new patient TRUS volume. We propose a framework for both modeling and prediction processes and evaluate it on a dataset of 60 brachytherapy treatment records. We show PTV prediction error of 10:02+/-4:5% and the V100 isodose overlap of 97+/-3:55% with respect to the clinical gold standard.

  3. Comparative analysis of operational forecasts versus actual weather conditions in airline flight planning, volume 1

    NASA Technical Reports Server (NTRS)

    Keitz, J. F.

    1982-01-01

    The impact of more timely and accurate weather data on airline flight planning with the emphasis on fuel savings is studied. This volume of the report discusses the results of Task 1 of the four major tasks included in the study. Task 1 compares flight plans based on forecasts with plans based on the verifying analysis from 33 days during the summer and fall of 1979. The comparisons show that: (1) potential fuel savings conservatively estimated to be between 1.2 and 2.5 percent could result from using more timely and accurate weather data in flight planning and route selection; (2) the Suitland forecast generally underestimates wind speeds; and (3) the track selection methodology of many airlines operating on the North Atlantic may not be optimum resulting in their selecting other than the optimum North Atlantic Organized Track about 50 percent of the time.

  4. Environmental Assessment, Wing Infrastructure Development Outlook (WINDO) Implementation Plan (FY 04-06). Volume 2, Beale Air Force Base, California

    DTIC Science & Technology

    2005-08-01

    Environmental Assessment Wing Infrastructure Development Outlook (WINDO) Implementation Plan (FY 04-06) Volume 2 Beale Air Force Base, California ...Development Outlook (WINDO) Implementation Plan (FY 04-06) Volume 2 Beale Air Force Base, California 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM...Beale Air Force Base (AFB). California : Volume 2. 2.0 DESCRIPTION OF PROPOSED ACTION AND NO ACTION ALTERNATIVES Proposed Action. The Proposed Action

  5. Launch vehicle test and checkout plan. - Volume 2: Saturn 1B launch vehicle Skylab R (rescue) and AS-208 flow plan and listings

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The launch operations test and checkout plan is a planning document that establishes all launch site checkout activity, including the individual tests and sequence of testing required to fulfill the development center and KSC test and checkout requirements. This volume contains the launch vehicle test and checkout plan encompassing S-1B, S-4B, IU stage, and ground support equipment tests. The plan is based upon AS-208 flow utilizing a manned spacecraft, LUT 1, and launch pad 39B facilities.

  6. Final consolidated action plan to Tiger Team. Volume 2, Change 1

    SciTech Connect

    Not Available

    1993-04-01

    Two separate Tiger Team assessments were conducted at Sandia National Laboratories (SNL). The first was conducted at the California site in Livermore between April 30, 1990, and May 18, 1990. A second Tiger Team assessment was conducted at the New Mexico site in Albuquerque between April 15 and May 24, 1991. This report is volume two, change one. One purpose of this Action Plan is to provide a formal written response to each of the findings and/or concerns cited in the SNL Tiger Team assessment reports. A second purpose is to present actions planned to be conducted to eliminate deficiencies identified by the Tiger Teams. A third purpose is to consolidate (group) related findings and to identify priorities assigned to the planned actions for improved efficiency and enhanced management of the tasks. A fourth and final purpose is to merge the two original SNL Action Plans for the New Mexico [Ref. a] and California [Ref. b] sites into a single Action Plan as a major step toward managing all SNL ES&H activities more similarly. Included in this combined SNL Action Plan are descriptions of the actions to be taken by SNL to liminate all problems identified in the Tiger Teams` findings/concerns, as well as estimated costs and schedules for planned actions.

  7. Management plan documentation standard and Data Item Descriptions (DID). Volume of the information system life-cycle and documentation standards, volume 2

    NASA Technical Reports Server (NTRS)

    Callender, E. David; Steinbacher, Jody

    1989-01-01

    This is the second of five volumes of the Information System Life-Cycle and Documentation Standards. This volume provides a well-organized, easily used standard for management plans used in acquiring, assuring, and developing information systems and software, hardware, and operational procedures components, and related processes.

  8. Closure plan for Solid Waste Storage Area 6: Volume 1, Closure plan

    SciTech Connect

    Not Available

    1988-09-01

    This Closure Plan for Solid Waste Storage Area 6 (SWSA 6) a disposal area for low-level radioactive wastes and hazardous materials, of the US Department of Energy (DOE) Oak Ridge National Laboratory (ORNL) describes how portions of SWSA 6 will be closed under Resource Conservation and Recovery Act (RCRA) Interim Status per 40 CFR 265 Subpart G (TN Rule 1200-1-11-.05(7)). An overview is provided of activities necessary for final closure and corrective measures for all of SWSA 6. Results of surface waters and groundwater sampling are provided.

  9. Strategic Planning: An Integrated Academic Information Management System (IAIMS) at Georgetown University Medical Center. Volume 1, Implementation Plan. Volume 2, Planning Accomplishments. Volume 3, Environmental Forecast. Volume 4, Institutional Self Study.

    ERIC Educational Resources Information Center

    Broering, Naomi C.; And Others

    Strategic planning for an Integrated Academic Information Management System (IAIMS) for Georgetown University Medical Center is considered. The goal is to organize and transmit accessible and timely biomedical information where it is needed. Activities are proposed for education, research, patient care, management, sharing information on…

  10. Strategic Planning: An Integrated Academic Information Management System (IAIMS) at Georgetown University Medical Center. Volume 1, Implementation Plan. Volume 2, Planning Accomplishments. Volume 3, Environmental Forecast. Volume 4, Institutional Self Study.

    ERIC Educational Resources Information Center

    Broering, Naomi C.; And Others

    Strategic planning for an Integrated Academic Information Management System (IAIMS) for Georgetown University Medical Center is considered. The goal is to organize and transmit accessible and timely biomedical information where it is needed. Activities are proposed for education, research, patient care, management, sharing information on…

  11. Impact of the accuracy of automatic tumour functional volume delineation on radiotherapy treatment planning.

    PubMed

    Le Maitre, Amandine; Hatt, Mathieu; Pradier, Olivier; Cheze-le Rest, Catherine; Visvikis, Dimitris

    2012-09-07

    Over the past few years several automatic and semi-automatic PET segmentation methods for target volume definition in radiotherapy have been proposed. The objective of this study is to compare different methods in terms of dosimetry. For such a comparison, a gold standard is needed. For this purpose, realistic GATE-simulated PET images were used. Three lung cases and three H&N cases were designed with various shapes, contrasts and heterogeneities. Four different segmentation approaches were compared: fixed and adaptive thresholds, a fuzzy C-mean and the fuzzy locally adaptive Bayesian method. For each of these target volumes, an IMRT treatment plan was defined. The different algorithms and resulting plans were compared in terms of segmentation errors and ground-truth volume coverage using different metrics (V(95), D(95), homogeneity index and conformity index). The major differences between the threshold-based methods and automatic methods occurred in the most heterogeneous cases. Within the two groups, the major differences occurred for low contrast cases. For homogeneous cases, equivalent ground-truth volume coverage was observed for all methods but for more heterogeneous cases, significantly lower coverage was observed for threshold-based methods. Our study demonstrates that significant dosimetry errors can be avoided by using more advanced image-segmentation methods.

  12. Impact of the accuracy of automatic tumour functional volume delineation on radiotherapy treatment planning

    NASA Astrophysics Data System (ADS)

    Le Maitre, Amandine; Hatt, Mathieu; Pradier, Olivier; Cheze-le Rest, Catherine; Visvikis, Dimitris

    2012-09-01

    Over the past few years several automatic and semi-automatic PET segmentation methods for target volume definition in radiotherapy have been proposed. The objective of this study is to compare different methods in terms of dosimetry. For such a comparison, a gold standard is needed. For this purpose, realistic GATE-simulated PET images were used. Three lung cases and three H&N cases were designed with various shapes, contrasts and heterogeneities. Four different segmentation approaches were compared: fixed and adaptive thresholds, a fuzzy C-mean and the fuzzy locally adaptive Bayesian method. For each of these target volumes, an IMRT treatment plan was defined. The different algorithms and resulting plans were compared in terms of segmentation errors and ground-truth volume coverage using different metrics (V95, D95, homogeneity index and conformity index). The major differences between the threshold-based methods and automatic methods occurred in the most heterogeneous cases. Within the two groups, the major differences occurred for low contrast cases. For homogeneous cases, equivalent ground-truth volume coverage was observed for all methods but for more heterogeneous cases, significantly lower coverage was observed for threshold-based methods. Our study demonstrates that significant dosimetry errors can be avoided by using more advanced image-segmentation methods.

  13. Target Volume Delineation for Partial Breast Radiotherapy Planning: Clinical Characteristics Associated with Low Interobserver Concordance

    SciTech Connect

    Petersen, Ross P.; Truong, Pauline T. Kader, Hosam A.; Berthelet, Eric; Lee, Junella C.; Hilts, Michelle L.; Kader, Adam S.; Beckham, Wayne A.; Olivotto, Ivo A.

    2007-09-01

    Purpose: To examine variability in target volume delineation for partial breast radiotherapy planning and evaluate characteristics associated with low interobserver concordance. Methods and Materials: Thirty patients who underwent planning CT for adjuvant breast radiotherapy formed the study cohort. Using a standardized scale to score seroma clarity and consensus contouring guidelines, three radiation oncologists independently graded seroma clarity and delineated seroma volumes for each case. Seroma geometric center coordinates, maximum diameters in three axes, and volumes were recorded. Conformity index (CI), the ratio of overlapping volume and encompassing delineated volume, was calculated for each case. Cases with CI {<=}0.50 were analyzed to identify features associated with low concordance. Results: The median time from surgery to CT was 42.5 days. For geometric center coordinates, variations from the mean were 0.5-1.1 mm and standard deviations (SDs) were 0.5-1.8 mm. For maximum seroma dimensions, variations from the mean and SDs were predominantly <5 mm, with the largest SDs observed in the medial-lateral axis. The mean CI was 0.61 (range, 0.27-0.84). Five cases had CI {<=}0.50. Conformity index was significantly associated with seroma clarity (p < 0.001) and seroma volume (p < 0.002). Features associated with reduced concordance included tissue stranding from the surgical cavity, proximity to muscle, dense breast parenchyma, and benign calcifications that may be mistaken for surgical clips. Conclusion: Variability in seroma contouring occurred in three dimensions, with the largest variations in the medial-lateral axis. Awareness of clinical features associated with reduced concordance may be applied toward training staff and refining contouring guidelines for partial breast radiotherapy trials.

  14. Dose-volume histogram quality assurance for linac-based treatment planning systems

    PubMed Central

    Gossman, Michael S.; Bank, Morris I.

    2010-01-01

    Dose–volume histograms provide key information to radiation oncologists when they assess the adequacy of a patient treatment plan in radiation therapy. It is important therefore that all clinically relevant data be accurate. In this article we present the first quality assurance routine involving a direct comparison of planning system results with the results obtained from independent hand calculations. Given a known three-dimensional (3-D) structure such as a parallelepiped, a simple beam arrangement, and known physics beam data, a time-efficient and reproducible method for verifying the accuracy of volumetric statistics (DVH) from a radiation therapy treatment planning system (TPS) can be employed rapidly, satisfying the QA requirements for (TPS) commissioning, upgrades, and annual checks. Using this method, the maximum disagreement was only 1.7% for 6 MV and 1.3% for 18 MV photon energies. The average accuracy was within 0.6% for 6 MV and 0.4% for 18 MV for all depth-dose results. A 2% disagreement was observed with the treatment planning system DVH from defined volume comparison to the known structure dimensions. PMID:21170183

  15. Comparative study of old and new versions of treatment planning system using dose volume histogram indices of clinical plans

    PubMed Central

    Krishna, Gangarapu Sri; Srinivas, Vuppu; Ayyangar, K. M.; Reddy, Palreddy Yadagiri

    2016-01-01

    Recently, Eclipse treatment planning system (TPS) version 8.8 was upgraded to the latest version 13.6. It is customary that the vendor gives training on how to upgrade the existing software to the new version. However, the customer is provided less inner details about changes in the new software version. According to manufacturer, accuracy of point dose calculations and irregular treatment planning is better in the new version (13.6) compared to the old version (8.8). Furthermore, the new version uses voxel-based calculations while the earlier version used point dose calculations. Major difference in intensity-modulated radiation therapy (IMRT) plans was observed between the two versions after re-optimization and re-calculations. However, minor difference was observed for IMRT cases after performing only re-calculations. It is recommended TPS quality assurance to be performed after any major upgrade of software. This can be done by performing dose calculation comparisons in TPS. To assess the difference between the versions, 25 clinical cases from the old version were compared keeping all the patient data intact including the monitor units and comparing the differences in dose calculations using dose volume histogram (DVH) analysis. Along with DVH analysis, uniformity index, conformity index, homogeneity index, and dose spillage index were also compared for both versions. The results of comparative study are presented in this paper. PMID:27651566

  16. PTV-based IMPT optimization incorporating planning risk volumes vs robust optimization

    SciTech Connect

    Liu Wei; Li Xiaoqiang; Zhu, Ron. X.; Mohan, Radhe; Frank, Steven J.; Li Yupeng

    2013-02-15

    Purpose: Robust optimization leads to intensity-modulated proton therapy (IMPT) plans that are less sensitive to uncertainties and superior in terms of organs-at-risk (OARs) sparing, target dose coverage, and homogeneity compared to planning target volume (PTV)-based optimized plans. Robust optimization incorporates setup and range uncertainties, which implicitly adds margins to both targets and OARs and is also able to compensate for perturbations in dose distributions within targets and OARs caused by uncertainties. In contrast, the traditional PTV-based optimization considers only setup uncertainties and adds a margin only to targets but no margins to the OARs. It also ignores range uncertainty. The purpose of this work is to determine if robustly optimized plans are superior to PTV-based plans simply because the latter do not assign margins to OARs during optimization. Methods: The authors retrospectively selected from their institutional database five patients with head and neck (H and N) cancer and one with prostate cancer for this analysis. Using their original images and prescriptions, the authors created new IMPT plans using three methods: PTV-based optimization, optimization based on the PTV and planning risk volumes (PRVs) (i.e., 'PTV+PRV-based optimization'), and robust optimization using the 'worst-case' dose distribution. The PRVs were generated by uniformly expanding OARs by 3 mm for the H and N cases and 5 mm for the prostate case. The dose-volume histograms (DVHs) from the worst-case dose distributions were used to assess and compare plan quality. Families of DVHs for each uncertainty for all structures of interest were plotted along with the nominal DVHs. The width of the 'bands' of DVHs was used to quantify the plan sensitivity to uncertainty. Results: Compared with conventional PTV-based and PTV+PRV-based planning, robust optimization led to a smaller bandwidth for the targets in the face of uncertainties {l_brace}clinical target volume [CTV

  17. Resource management plan for the Oak Ridge Reservation. Volume 27, Wildlife Management Plan

    SciTech Connect

    Parr, P.D.; Evans, J.W.

    1992-06-01

    A plan for management of the wildlife resources on the US Department of Energy`s Oak Ridge Reservation is outlined in this document. Management includes wildlife population control (hunts, trapping, and removal), handling specific problems with wildlife, restoration of species, coordination with researchers on wildlife studies, preservation and management of habitats, and law enforcement. Wildlife resources are divided into five categories, each with a specific set of objectives and procedures for obtaining these objectives. These categories are (1) species-richness management to ensure that all resident wildlife species exist on the Reservation in viable numbers; (2) featured species management to produce selected species in desired numbers on designated land units; (3) management of game species for research, education, recreation, and public safety, (4) endangered species management designed to preserve and protect both the species and habitats critical to the survival of those species; and (5) pest management. Achievement of the objectives is a joint effort between the Tennessee Wildlife Resources Agency and the Oak Ridge National Laboratory`s Environmental Sciences Division.

  18. Viability Assessment of a Repository at Yucca Mountain. Volume 4: License Application Plan and Costs

    SciTech Connect

    1998-12-01

    Volume 4 provides the DOE plan and cost estimate for the remaining work necessary to proceed from completing this VA to submitting an LA to NRC. This work includes preparing an EIS and evaluating the suitability of the site. Both items are necessary components of the documentation required to support a decision in 2001 by the Secretary of Energy on whether or not to recommend that the President approve the site for development as a repository. If the President recommends the site to Congress and the site designation becomes effective, then DOE will submit the LA to NRC in 2002 for authorization to construct the repository. The work described in Volume 4 constitutes the last step in the characterization of the Yucca Mountain site and the design and evaluation of the performance of a repository system in the geologic setting of this site. The plans in this volume for the next 4 years' work are based on the results of the previous 15 years' work, as reported in Volumes 1, 2, and 3 of this VA. Volume 1 summarizes what DOE has learned to date about the Yucca Mountain site. Volume 2 describes the current, reference repository design, several design options that might enhance the performance of the reference design, and several alternative designs that represent substantial departures from the reference design. Volume 2 also summarizes the results of tests of candidate materials for waste packages and for support of the tunnels into which waste would be emplaced. Volume 3 provides the results of the latest performance assessments undertaken to evaluate the performance of the design in the geologic setting of Yucca Mountain. The results described in Volumes 1, 2, and 3 provide the basis for identifying and prioritizing the work described in this volume. DOE believes that the planned work, together with the results of previous work, will be sufficient to support a site suitability evaluation for site recommendation and, if the site is recommended and designated, a

  19. Comparison of dose–volume analysis between standard Manchester plan and magnetic resonance image-based plan of intracavitary brachytherapy for uterine cervical cancer

    PubMed Central

    Takenaka, Tadashi; Yoshida, Ken; Tachiiri, Seiji; Yamazaki,, Hideya; Aramoto, Kazumasa; Furuya, Seiichi; Yoshida, Mineo; Ban, Chiaki; Tanaka, Eiichi; Honda, Kazuya

    2012-01-01

    To investigate the feasibility of image-based intracavitary brachytherapy (IBICBT) for uterine cervical cancer, we evaluated the dose–volume histograms (DVHs) for the tumor and organs at risk (OARs) and compared results from the IBICBT plan and the standard Manchester system (Manchester plan) in eight patients as a simulation experiment. We performed magnetic resonance imaging (MRI) and computed tomography (CT) following MRI-adapted applicator insertion, then superimposed MR images on the planning CT images to describe the contours of high-risk clinical target volume (HR CTV) and OARs. The median volume of HR CTV was 29 cm3 (range, 21–61 cm3). Median D90 (HR CTV) and V100 (HR CTV) were 116.1% prescribed doses (PD) (90.0–150.8%) and 96.7% (84.2–100%), respectively, for the Manchester plan. In comparison, we confirmed that the median D90 (HR CTV) was 100% PD in the IBICBT plan for all patients. Mean D2cc (bladder) was 101.8% PD for the Manchester plan and 83.2% PD for the IBICBT plan. Mean D2cc (rectum) was 80.1% PD for the Manchester plan and 64.2% PD for the IBICBT plan. Mean D2cc (sigmoid) was 75% PD for the Manchester plan and 57.5% PD for the IBICBT plan. One patient with a large tumor (HR CTV, 61 cm3) showed lower D90 (HR CTV) with the Manchester plan than with the IBICBT plan. The Manchester plan may represent overtreatment for small tumors but insufficient dose distribution for larger tumors. The IBICBT plan could reduce OAR dosage while maintaining adequate tumor coverage. PMID:22843369

  20. [Margin determination from clinical to planning target volume for lung cancer treated with conformal or intensity-modulated irradiation].

    PubMed

    Berthelot, K; Thureau, S; Giraud, P

    2016-10-01

    Technological progress in radiotherapy enables more precision for treatment planning and delivery. The margin determination between the clinical target volume and the planning target volumes stem from the estimation of geometric uncertainties of the tumour localization into the radiation beam. The inner motion complexity of lung tumours has led to the use of 4D computed tomography and nurtures specific dosimetric concerns. Few strategies consisting in integrating tumour motion allow margin reduction regarding inner movements. The patient immobilization and onboard imagery improvement decrease the setup uncertainties. Each step between the initial planning imagery and treatment delivery has to be analysed as systematic or random errors to calculate the optimal planning margin.

  1. Three dimensional planning target volumes: a model and a software tool.

    PubMed

    Austin-Seymour, M; Kalet, I; McDonald, J; Kromhout-Schiro, S; Jacky, J; Hummel, S; Unger, J

    1995-12-01

    Three dimensional (3D) target volumes are an essential component of conformal therapy because the goal is to shape the treatment volume to the target volume. The planning target volume (PTV) is defined by ICRU 50 as the clinical target volume (CTV) plus a margin to ensure that the CTV receives the prescribed dose. The margin must include all interfractional and intrafractional treatment variations. This paper describes a software tool that automatically generates 3D PTVs from CTVs for lung cancers and immobile head and neck cancers. Values for the interfractional and intrafractional treatment variations were determined by a literature review and by targeted interviews with physicians. The software tool is written in Common LISP and conforms to the specifications for shareable software of the Radiotherapy Treatment Planning Tools Collaborative Working Group. The tool is a rule-based expert system in which the inputs are the CTV contours, critical structure contours, and qualitative information about the specific patient. The output is PTV contours, which are a cylindrical expansion of the CTV. A model for creating PTVs from CTVs is embedded in the tool. The interfractional variation of setup uncertainty and the intrafractional variations of movement of the CTV (e.g., respiration) and patient motion are included in the model. Measured data for the component variations is consistent with modeling the components as independent samples from 3D Gaussian distributions. The components are combined using multivariate normal statistics to yield the cylindrical expansion factors. Rules are used to represent the values of the components for certain patient conditions (e.g., setup uncertainty for a head and neck patient immobilized in a mask). The tool uses a rule interpreter to combine qualitative information about a specific patient with rules representing the value of the components and to enter the appropriate component values for that patient into the cylindrical expansion

  2. Comparative analysis of operational forecasts versus actual weather conditions in airline flight planning, volume 2

    NASA Technical Reports Server (NTRS)

    Keitz, J. F.

    1982-01-01

    The impact of more timely and accurate weather data on airline flight planning with the emphasis on fuel savings is studied. This volume of the report discusses the results of Task 2 of the four major tasks included in the study. Task 2 compares various catagories of flight plans and flight tracking data produced by a simulation system developed for the Federal Aviation Administrations by SRI International. (Flight tracking data simulate actual flight tracks of all aircraft operating at a given time and provide for rerouting of flights as necessary to resolve traffic conflicts.) The comparisons of flight plans on the forecast to flight plans on the verifying analysis confirm Task 1 findings that wind speeds are generally underestimated. Comparisons involving flight tracking data indicate that actual fuel burn is always higher than planned, in either direction, and even when the same weather data set is used. Since the flight tracking model output results in more diversions than is known to be the case, it was concluded that there is an error in the flight tracking algorithm.

  3. Management response plan for the Chemical Safety Vulnerability Working Group report. Volume 2

    SciTech Connect

    Not Available

    1994-09-01

    The Chemical Safety Vulnerability (CSV) Working Group was established to identify adverse conditions involving hazardous chemicals at DOE facilities that might result in fires or explosions, release of hazardous chemicals to the environment, or exposure of workers or the public to chemicals. A CSV Review was conducted in 146 facilities at 29 sites. Eight generic vulnerabilities were documented related to: abandoned chemicals and chemical residuals; past chemical spills and ground releases; characterization of legacy chemicals and wastes; disposition of legacy chemicals; storage facilities and conditions; condition of facilities and support systems; unanalyzed and unaddressed hazards; and inventory control and tracking. Weaknesses in five programmatic areas were also identified related to: management commitment and planning; chemical safety management programs; aging facilities that continue to operate; nonoperating facilities awaiting deactivation; and resource allocations. To address the facility-specific and site-specific vulnerabilities, responsible DOE and site-contractor line organizations have developed initial site response plans. These plans, presented as Volume 2 of this Management Response Plan, describe the actions needed to mitigate or eliminate the facility- and site-specific vulnerabilities identified by the CSV Working Group field verification teams. Initial site response plans are described for: Brookhaven National Lab., Hanford Site, Idaho National Engineering Lab., Lawrence Livermore National Lab., Los Alamos National Lab., Oak Ridge Reservation, Rocky Flats Plant, Sandia National Laboratories, and Savannah River Site.

  4. Dose and volume parameters for MRI-based treatment planning in intracavitary brachytherapy for cervical cancer

    SciTech Connect

    Kirisits, Christian . E-mail: Christian.Kirisits@meduniwien.ac.at; Poetter, Richard; Lang, Stefan; Dimopoulos, Johannes; Wachter-Gerstner, Natascha; Georg, Dietmar

    2005-07-01

    Purpose: Magnetic resonance imaging (MRI)-based treatment planning in intracavitary brachytherapy allows optimization of the dose distribution on a patient-by-patient basis. In addition to traditionally used point dose and volume parameters, dose-volume histogram (DVH) analysis enables further possibilities for prescribing and reporting. This study reports the systematic development of our concept applied in clinical routine. Methods and Materials: A group of 22 patients treated with 93 fractions using a tandem-ring applicator and MRI-based individual treatment planning for each application was analyzed in detail. High-risk clinical target volumes and gross tumor volumes were contoured. The dose to bladder, rectum, and sigma was analyzed according to International Commission of Radiation Units and Measurements (ICRU) Report 38 and DVH parameters (e.g., D{sub 2cc} represents the minimal dose for the most irradiated 2 cm{sup 3}). Total doses, including external beam radiotherapy and the values for each individual brachytherapy fraction, were biologically normalized to conventional 2-Gy fractions ({alpha}/{beta} 10 Gy for target, 3 Gy for organs at risk). Results: The total prescribed dose was about 85 Gy{sub {alpha}}{sub {beta}}{sub 10}, which was mainly achieved by 45 Gy external beam radiotherapy plus 4 x 7 Gy brachytherapy (total 84 Gy{sub {alpha}}{sub {beta}}{sub 10}). The mean value was 82 Gy{sub {alpha}}{sub {beta}}{sub 10} for the point A dose (left, right) and 84 cm{sup 3} for the volume of the prescribed dose. The average dose to the clinical target volume was 66 Gy{sub {alpha}}{sub {beta}}{sub 10} for the minimum target dose, 87 Gy{sub {alpha}}{sub {beta}}{sub 10} for the dose received by at least 90% of the volume, with a mean volume treated with at least the prescribed dose of 89%. The mean D{sub 2cc} for the bladder was 83 Gy{sub {alpha}}{sub {beta}}{sub 3}, the ICRU point dose was 75 Gy{sub {alpha}}{sub {beta}}{sub 3}, and the dose at the ICRU point

  5. Comparative analysis of operational forecasts versus actual weather conditions in airline flight planning, volume 4

    NASA Technical Reports Server (NTRS)

    Keitz, J. F.

    1982-01-01

    The impact of more timely and accurate weather data on airline flight planning with the emphasis on fuel savings is studied. This volume of the report discusses the results of Task 4 of the four major tasks included in the study. Task 4 uses flight plan segment wind and temperature differences as indicators of dates and geographic areas for which significant forecast errors may have occurred. An in-depth analysis is then conducted for the days identified. The analysis show that significant errors occur in the operational forecast on 15 of the 33 arbitrarily selected days included in the study. Wind speeds in an area of maximum winds are underestimated by at least 20 to 25 kts. on 14 of these days. The analysis also show that there is a tendency to repeat the same forecast errors from prog to prog. Also, some perceived forecast errors from the flight plan comparisons could not be verified by visual inspection of the corresponding National Meteorological Center forecast and analyses charts, and it is likely that they are the result of weather data interpolation techniques or some other data processing procedure in the airlines' flight planning systems.

  6. Adaptive Radiotherapy Planning on Decreasing Gross Tumor Volumes as Seen on Megavoltage Computed Tomography Images

    SciTech Connect

    Woodford, Curtis; Yartsev, Slav Dar, A. Rashid; Bauman, Glenn; Van Dyk, Jake

    2007-11-15

    Purpose: To evaluate gross tumor volume (GTV) changes for patients with non-small-cell lung cancer by using daily megavoltage (MV) computed tomography (CT) studies acquired before each treatment fraction on helical tomotherapy and to relate the potential benefit of adaptive image-guided radiotherapy to changes in GTV. Methods and Materials: Seventeen patients were prescribed 30 fractions of radiotherapy on helical tomotherapy for non-small-cell lung cancer at London Regional Cancer Program from Dec 2005 to March 2007. The GTV was contoured on the daily MVCT studies of each patient. Adapted plans were created using merged MVCT-kilovoltage CT image sets to investigate the advantages of replanning for patients with differing GTV regression characteristics. Results: Average GTV change observed over 30 fractions was -38%, ranging from -12 to -87%. No significant correlation was observed between GTV change and patient's physical or tumor features. Patterns of GTV changes in the 17 patients could be divided broadly into three groups with distinctive potential for benefit from adaptive planning. Conclusions: Changes in GTV are difficult to predict quantitatively based on patient or tumor characteristics. If changes occur, there are points in time during the treatment course when it may be appropriate to adapt the plan to improve sparing of normal tissues. If GTV decreases by greater than 30% at any point in the first 20 fractions of treatment, adaptive planning is appropriate to further improve the therapeutic ratio.

  7. Lesson Plans for the Busy Librarian: A Standards Based Approach for the Elementary Library Media Center, Volume 2

    ERIC Educational Resources Information Center

    Keeling, Joyce

    2005-01-01

    The author designed this book, like Volume I of the set, to give elementary school librarians a quick, enjoyable way to coordinate with teachers to teach information literacy and literacy skills aligned with national standards. The chapters in the book include: (1) Kindergarten Lesson Plans; (2) First-Grade Lesson Plans; (3) Second-Grade Lesson…

  8. Report to the Government of Jamaica coal feasibility study and financing plan. Phase 2, volume 1. Export trade information

    SciTech Connect

    1983-09-01

    The report shows the results of a study conducted to determine the feasibility of an oil-to-coal conversion program for Jamaica`s major energy consuming facilities. This report, which is Phase II of the study, prepares the specifications for the principal equipment and develops financing and implementation plans for the project. The study is divided into two volumes. This is Volume 1 and it includes the following sections: (1) Executive Summary; (2) Selection of Preferred Option; (3) Conceptual Design; (4) Pricing of Equipment; (5) Coal Procurement; (6) Financial Analysis and Financing Plan; and (7) Project Plan.

  9. WE-B-304-01: Treatment Planning Evaluation and Optimization Should Be Dose/volume and Not Biologically Based

    SciTech Connect

    Mayo, C.

    2015-06-15

    The ultimate goal of radiotherapy treatment planning is to find a treatment that will yield a high tumor control probability (TCP) with an acceptable normal tissue complication probability (NTCP). Yet most treatment planning today is not based upon optimization of TCPs and NTCPs, but rather upon meeting physical dose and volume constraints defined by the planner. It has been suggested that treatment planning evaluation and optimization would be more effective if they were biologically and not dose/volume based, and this is the claim debated in this month’s Point/Counterpoint. After a brief overview of biologically and DVH based treatment planning by the Moderator Colin Orton, Joseph Deasy (for biological planning) and Charles Mayo (against biological planning) will begin the debate. Some of the arguments in support of biological planning include: this will result in more effective dose distributions for many patients DVH-based measures of plan quality are known to have little predictive value there is little evidence that either D95 or D98 of the PTV is a good predictor of tumor control sufficient validated outcome prediction models are now becoming available and should be used to drive planning and optimization Some of the arguments against biological planning include: several decades of experience with DVH-based planning should not be discarded we do not know enough about the reliability and errors associated with biological models the radiotherapy community in general has little direct experience with side by side comparisons of DVH vs biological metrics and outcomes it is unlikely that a clinician would accept extremely cold regions in a CTV or hot regions in a PTV, despite having acceptable TCP values Learning Objectives: To understand dose/volume based treatment planning and its potential limitations To understand biological metrics such as EUD, TCP, and NTCP To understand biologically based treatment planning and its potential limitations.

  10. WE-B-304-02: Treatment Planning Evaluation and Optimization Should Be Biologically and Not Dose/volume Based

    SciTech Connect

    Deasy, J.

    2015-06-15

    The ultimate goal of radiotherapy treatment planning is to find a treatment that will yield a high tumor control probability (TCP) with an acceptable normal tissue complication probability (NTCP). Yet most treatment planning today is not based upon optimization of TCPs and NTCPs, but rather upon meeting physical dose and volume constraints defined by the planner. It has been suggested that treatment planning evaluation and optimization would be more effective if they were biologically and not dose/volume based, and this is the claim debated in this month’s Point/Counterpoint. After a brief overview of biologically and DVH based treatment planning by the Moderator Colin Orton, Joseph Deasy (for biological planning) and Charles Mayo (against biological planning) will begin the debate. Some of the arguments in support of biological planning include: this will result in more effective dose distributions for many patients DVH-based measures of plan quality are known to have little predictive value there is little evidence that either D95 or D98 of the PTV is a good predictor of tumor control sufficient validated outcome prediction models are now becoming available and should be used to drive planning and optimization Some of the arguments against biological planning include: several decades of experience with DVH-based planning should not be discarded we do not know enough about the reliability and errors associated with biological models the radiotherapy community in general has little direct experience with side by side comparisons of DVH vs biological metrics and outcomes it is unlikely that a clinician would accept extremely cold regions in a CTV or hot regions in a PTV, despite having acceptable TCP values Learning Objectives: To understand dose/volume based treatment planning and its potential limitations To understand biological metrics such as EUD, TCP, and NTCP To understand biologically based treatment planning and its potential limitations.

  11. Energy self-sufficiency for the County of Kauai. Volume 2. General energy plan

    SciTech Connect

    Kai, K.; Browne, S.; Hahn, Y.; Seki, A.

    1980-06-01

    Volume 1 of this study presented background information concerning the environment, the economy, past trends in the use of energy, and potentially available natural energy resources of Kauai. In Section II of this volume, Vol. 2, present energy-use patterns are described, updating the data of Volume 1 through 1978. Based upon past trends, three plausible scenarios of future economic growth and the corresponding projections of future energy demand are developed in Section III. Potential sources of energy to meet projected demands are discussed in Section IV, including conservation and indigenous energy resources. The present state of energy technology and its implications for Kauai are reviewed, economic factors and environmental impact issues that will influence selection of sources are discussed, and current and planned RD and D programs are described. Section V presents an energy-supply projection to be used in subsequent analysis. It represents a reasonable growth pattern in which sources available immediately and in the near future, conservation, biomass, solar water heating, and wind, are utilized in earlier years, augmented by solar power generation and ocean energy conversion, as they might be expected to become available. The results of analysis of the impact of this supply projection on each projected demand are discussed, including some economic impacts and alternatives that might increase future supply when projected supplies fall short of demand. Some general conclusions are drawn in Section VI.

  12. Education as Experimentation: A Planned Variation Model. Volume IV-E. Supplementary Analyses: Reanalysis of Selected Data Sets. Volume IV-F. Supplementary Analyses: Appendix.

    ERIC Educational Resources Information Center

    Proper, Elizabeth C.; And Others

    This segment of the national evaluation study of the Follow Through Planned Variation Model discusses findings of analyses of achievement test data which have been adjusted to take into consideration the preschool experience of children in three Follow Through cohorts. These analyses serve as a supplement to analyses presented in Volume IV-A of…

  13. Education as Experimentation: A Planned Variation Model. Volume IV-E. Supplementary Analyses: Reanalysis of Selected Data Sets. Volume IV-F. Supplementary Analyses: Appendix.

    ERIC Educational Resources Information Center

    Proper, Elizabeth C.; And Others

    This segment of the national evaluation study of the Follow Through Planned Variation Model discusses findings of analyses of achievement test data which have been adjusted to take into consideration the preschool experience of children in three Follow Through cohorts. These analyses serve as a supplement to analyses presented in Volume IV-A of…

  14. Comparative analysis of operational forecasts versus actual weather conditions in airline flight planning, volume 3

    NASA Technical Reports Server (NTRS)

    Keitz, J. F.

    1982-01-01

    The impact of more timely and accurate weather data on airline flight planning with the emphasis on fuel savings is studied. This volume of the report discusses the results of Task 3 of the four major tasks included in the study. Task 3 compares flight plans developed on the Suitland forecast with actual data observed by the aircraft (and averaged over 10 degree segments). The results show that the average difference between the forecast and observed wind speed is 9 kts. without considering direction, and the average difference in the component of the forecast wind parallel to the direction of the observed wind is 13 kts. - both indicating that the Suitland forecast underestimates the wind speeds. The Root Mean Square (RMS) vector error is 30.1 kts. The average absolute difference in direction between the forecast and observed wind is 26 degrees and the temperature difference is 3 degree Centigrade. These results indicate that the forecast model as well as the verifying analysis used to develop comparison flight plans in Tasks 1 and 2 is a limiting factor and that the average potential fuel savings or penalty are up to 3.6 percent depending on the direction of flight.

  15. Comp Plan: A computer program to generate dose and radiobiological metrics from dose-volume histogram files

    SciTech Connect

    Holloway, Lois Charlotte; Miller, Julie-Anne; Kumar, Shivani; Whelan, Brendan M.; Vinod, Shalini K.

    2012-10-01

    Treatment planning studies often require the calculation of a large number of dose and radiobiological metrics. To streamline these calculations, a computer program called Comp Plan was developed using MATLAB. Comp Plan calculates common metrics, including equivalent uniform dose, tumor control probability, and normal tissue complication probability from dose-volume histogram data. The dose and radiobiological metrics can be calculated for the original data or for an adjusted fraction size using the linear quadratic model. A homogeneous boost dose can be added to a given structure if desired. The final output is written to an Excel file in a format convenient for further statistical analysis. Comp Plan was verified by independent calculations. A lung treatment planning study comparing 45 plans for 7 structures using up to 6 metrics for each structure was successfully analyzed within approximately 5 minutes with Comp Plan. The code is freely available from the authors on request.

  16. Selected Bibliographies and State-of-the-Art Review for Environmental Health. Volume 2: Environmental Health References. International Health Planning Reference Series.

    ERIC Educational Resources Information Center

    Fraser, Renee White; Shani, Hadasa

    Intended as a companion piece to volume 2 in the Method Series, Environmental Health Planning (CE 024 230), this second of six volumes in the International Health Planning Reference Series is a combined literature review and annotated bibliography dealing with environmental factors in health planning for developing countries. The review identifies…

  17. Maximum-Intensity Volumes for Fast Contouring of Lung Tumors Including Respiratory Motion in 4DCT Planning

    SciTech Connect

    Rietzel, Eike Liu, Arthur K.; Chen, George T.Y.; Choi, Noah C.

    2008-07-15

    Purpose: To assess the accuracy of maximum-intensity volumes (MIV) for fast contouring of lung tumors including respiratory motion. Methods and Materials: Four-dimensional computed tomography (4DCT) data of 10 patients were acquired. Maximum-intensity volumes were constructed by assigning the maximum Hounsfield unit in all CT volumes per geometric voxel to a new, synthetic volume. Gross tumor volumes (GTVs) were contoured on all CT volumes, and their union was constructed. The GTV with all its respiratory motion was contoured on the MIV as well. Union GTVs and GTVs including motion were compared visually. Furthermore, planning target volumes (PTVs) were constructed for the union of GTVs and the GTV on MIV. These PTVs were compared by centroid position, volume, geometric extent, and surface distance. Results: Visual comparison of GTVs demonstrated failure of the MIV technique for 5 of 10 patients. For adequate GTV{sub MIV}s, differences between PTVs were <1.0 mm in centroid position, 5% in volume, {+-}5 mm in geometric extent, and {+-}0.5 {+-} 2.0 mm in surface distance. These values represent the uncertainties for successful MIV contouring. Conclusion: Maximum-intensity volumes are a good first estimate for target volume definition including respiratory motion. However, it seems mandatory to validate each individual MIV by overlaying it on a movie loop displaying the 4DCT data and editing it for possible inadequate coverage of GTVs on additional 4DCT motion states.

  18. Brain tumor target volume determination for radiation therapy treatment planning through the use of automated MRI segmentation

    NASA Astrophysics Data System (ADS)

    Mazzara, Gloria Patrika

    Radiation therapy seeks to effectively irradiate the tumor cells while minimizing the dose to adjacent normal cells. Prior research found that the low success rates for treating brain tumors would be improved with higher radiation doses to the tumor area. This is feasible only if the target volume can be precisely identified. However, the definition of tumor volume is still based on time-intensive, highly subjective manual outlining by radiation oncologists. In this study the effectiveness of two automated Magnetic Resonance Imaging (MRI) segmentation methods, k-Nearest Neighbors (kNN) and Knowledge-Guided (KG), in determining the Gross Tumor Volume (GTV) of brain tumors for use in radiation therapy was assessed. Three criteria were applied: accuracy of the contours; quality of the resulting treatment plan in terms of dose to the tumor; and a novel treatment plan evaluation technique based on post-treatment images. The kNN method was able to segment all cases while the KG method was limited to enhancing tumors and gliomas with clear enhancing edges. Various software applications were developed to create a closed smooth contour that encompassed the tumor pixels from the segmentations and to integrate these results into the treatment planning software. A novel, probabilistic measurement of accuracy was introduced to compare the agreement of the segmentation methods with the weighted average physician volume. Both computer methods under-segment the tumor volume when compared with the physicians but performed within the variability of manual contouring (28% +/- 12% for inter-operator variability). Computer segmentations were modified vertically to compensate for their under-segmentation. When comparing radiation treatment plans designed from physician-defined tumor volumes with treatment plans developed from the modified segmentation results, the reference target volume was irradiated within the same level of conformity. Analysis of the plans based on post

  19. West Antarctic Ice Sheet Initiative. Volume 1: Science and Implementation Plan

    NASA Technical Reports Server (NTRS)

    Bindschadler, Robert A. (Editor)

    1990-01-01

    The Science and Implementation Plan of the West Antarctic Ice Sheet Initiative (WAIS) is described. The goal of this initiative is the prediction of the future behavior of this ice sheet and an assessment of its potential to collapse, rapidly raising global sea level. The multidisciplinary nature of WAIS reflects the complexity of the polar ice sheet environment. The project builds upon past and current polar studies in many fields and meshes with future programs of both the U.S. and other countries. Important tasks in each discipline are described and a coordinated schedule by which the majority of these tasks can be accomplished in 5 years is presented. The companion report (Volume 2) contains seven discipline review papers on the state of knowledge of Antarctica and opinions on how that knowledge must be increased to attain the WAIS goal.

  20. Remedial Investigation concept plan for Picatinny arsenal: Volume 1, Environmental setting, applicable regulations, summaries of site sampling plans, sampling priorities, and supporting appendixes

    SciTech Connect

    Benioff, P.A.; Bhattacharyya, M.H.; Biang, C.; Chiu, S.Y.; Miller, S.; Patton, T.; Pearl, R.; Yonk, A.; Yuen, C.R. )

    1991-03-01

    Argonne National Laboratory has prepared a Remedial Investigation (RI) Concept Plan for Picatinny Arsenal in New Jersey. Based on types of activity and location, the 156 RI Sites identified during the study are grouped into 16 Areas. The plan assesses the environmental status and identifies additional data needed for each RI Site in each Area. The plan was developed to comply with state and federal hazardous waste and water quality regulations. The plan also provides a ranking of the 16 Areas according to their potential for impacts on public health and the environment. Volume 1 describes the environmental setting of Picatinny Arsenal, discusses applicable federal and state environmental regulations, briefly describes the Areas and the Sites within each Area, provides a ranking of the Areas, summarizes the proposed RI sampling plan for each Site in each Area, and gives supplementary information. 60 refs., 9 figs., 25 tabs.

  1. Determination of planning target volume for whole stomach irradiation using daily megavoltage computed tomographic images.

    PubMed

    Johnson, Matthew E; Pereira, Gisele C; El Naqa, Issam M; Goddu, S Murty; Al-Lozi, Rawan; Apte, Aditya; Mansur, David B

    2012-01-01

    Whole stomach radiation therapy is often used in the management of gastric lymphoma. However, very limited data exist with regard to planning target volume requirements for the whole stomach. This study retrospectively analyzed daily megavoltage computed tomographic (CT) scans of gastric lymphoma patients in order to help determine the interfraction variation of the stomach position. Forty-one daily megavoltage CT images from 3 gastric lymphoma patients were used for stomach contouring. Each patient's megavoltage CT images were rigidly registered to their CT simulation data sets, and the margin in each direction that covered at least 95% of the daily stomach volumes was computed using a simple grid search. Patient setup variation was also calculated from the daily patient shifts. The organ motion margin was then added to the setup margin to render the total margin. A uniform margin of 2.2 cm is required to cover 95% of the stomach over the treatment course. However, direction-specific margins were observed from 1.72, 1.88, 0.92, 2.23, 1.90, and 0.86 cm for the right, left, posterior, anterior, superior, and inferior directions, respectively. The results of this study provide helpful 3-dimensional volumetric information to the limited existing data on margin requirements for whole stomach radiation therapy. Copyright © 2012 American Society for Radiation Oncology. Published by Elsevier Inc. All rights reserved.

  2. Management response plan for the Chemical Safety Vulnerability Working Group report. Volume 1

    SciTech Connect

    Not Available

    1994-09-01

    The Chemical Safety Vulnerability (CSV) Working Group was established to identify adverse conditions involving hazardous chemicals at DOE facilities that might result in fires or explosions, release of hazardous chemicals to the environment, or exposure of workers or the public to chemicals. A CSV Review was conducted in 146 facilities at 29 sites. Eight generic vulnerabilities were documented related to: abandoned chemicals and chemical residuals; past chemical spills and ground releases; characterization of legacy chemicals and wastes; disposition of legacy chemicals; storage facilities and conditions; condition of facilities and support systems; unanalyzed and unaddressed hazards; and inventory control and tracking. Weaknesses in five programmatic areas were also identified related to: management commitment and planning; chemical safety management programs; aging facilities that continue to operate; nonoperating facilities awaiting deactivation; and resource allocations. Volume 1 contains a discussion of the chemical safety improvements planned or already underway at DOE sites to correct facility or site-specific vulnerabilities. The main part of the report is a discussion of each of the programmatic deficiencies; a description of the tasks to be accomplished; the specific actions to be taken; and the organizational responsibilities for implementation.

  3. [Planning of volume and terms of orthodontic treatment of patients with transversal maloclusion].

    PubMed

    Смаглюк, Любовь В; Белоус, Алевтина Н

    2016-01-01

    In planning of orthodontic treatment, as well as the alleged end of the treatment of orthodontic patients with transversal malocclusion should first pay attention to the treatment of opportunistic diseases that can affect the outcome of treatment of orthodontic patients (for example, rehabilitation of the nasopharynx, the treatment of rickets, the treatment of scoliosis posture, scoliosis ). definition of related factors affecting the volume and timing of the treatment of patients with transversal malocclusion. There were examined 32 patients with transversal malocclusion, and studied their medical history (Form 043). Patients were examined by standard algorithm survey. Two groups of patients by sex: Group 1: girls - 16 people and 2-th group: boys- 16 people. The material collected from 2010 to 2015. Patient age - 12-17 years. Subjective attitude to the disease formed on the basis of a number of factors that can be grouped into the following categories: social and constitutional and individual psychological. Since incorrect posture and malocclusion are the cause and effect of each other, in such cases should be treated at the same time and bite and pathology of the musculoskeletal system (10, 11). It is clear that in the planning of orthodontic treatment should be part and treatment of posture and a close and fruitful collaboration with the doctor traumatologist orthopaedist. The sex of the patient, especially temperament, the doctor-patient relationship, as well as the presence of somatic diseases have a significant impact on the length and complexity of the orthodontic treatment.

  4. Planning for an energy-efficient future: The experience with implementing energy conservation programs for new residential and commercial buildings: Volume 2, Program descriptions

    SciTech Connect

    Vine, E.; Harris, J.

    1988-09-01

    This volume contains the descriptions of programs contained in Volume 1 of our main report: Planning for an Energy-Efficient Future: The Experience With Implementing Energy Conservation Programs For New Residential and Commercial Buildings (LBL-25525).

  5. SU-E-T-546: Use of Implant Volume for Quality Assurance of Low Dose Rate Brachytherapy Treatment Plans

    SciTech Connect

    Wilkinson, D; Kolar, M

    2014-06-01

    Purpose: To analyze the application of volume implant (V100) data as a method for a global check of low dose rate (LDR) brachytherapy plans. Methods: Treatment plans for 335 consecutive patients undergoing permanent seed implants for prostate cancer and for 113 patients treated with plaque therapy for ocular melanoma were analyzed. Plaques used were 54 COMS (10 to 20 mm, notched and regular) and 59 Eye Physics EP917s with variable loading. Plots of treatment time x implanted activity per unit dose versus v100 ^.667 were made. V100 values were obtained using dose volume histograms calculated by the treatment planning systems (Variseed 8.02 and Plaque Simulator 5.4). Four different physicists were involved in planning the prostate seed cases; two physicists for the eye plaques. Results: Since the time and dose for the prostate cases did not vary, a plot of implanted activity vs V100 ^.667 was made. A linear fit with no intercept had an r{sup 2} = 0.978; more than 94% of the actual activities fell within 5% of the activities calculated from the linear fit. The greatest deviations were in cases where the implant volumes were large (> 100 cc). Both COMS and EP917 plaque linear fits were good (r{sup 2} = .967 and .957); the largest deviations were seen for large volumes. Conclusions: The method outlined here is effective for checking planning consistency and quality assurance of two types of LDR brachytherapy treatment plans (temporary and permanent). A spreadsheet for the calculations enables a quick check of the plan in situations were time is short (e.g. OR-based prostate planning)

  6. Radiotherapy planning for glioblastoma based on a tumor growth model: improving target volume delineation

    NASA Astrophysics Data System (ADS)

    Unkelbach, Jan; Menze, Bjoern H.; Konukoglu, Ender; Dittmann, Florian; Le, Matthieu; Ayache, Nicholas; Shih, Helen A.

    2014-02-01

    Glioblastoma differ from many other tumors in the sense that they grow infiltratively into the brain tissue instead of forming a solid tumor mass with a defined boundary. Only the part of the tumor with high tumor cell density can be localized through imaging directly. In contrast, brain tissue infiltrated by tumor cells at low density appears normal on current imaging modalities. In current clinical practice, a uniform margin, typically two centimeters, is applied to account for microscopic spread of disease that is not directly assessable through imaging. The current treatment planning procedure can potentially be improved by accounting for the anisotropy of tumor growth, which arises from different factors: anatomical barriers such as the falx cerebri represent boundaries for migrating tumor cells. In addition, tumor cells primarily spread in white matter and infiltrate gray matter at lower rate. We investigate the use of a phenomenological tumor growth model for treatment planning. The model is based on the Fisher-Kolmogorov equation, which formalizes these growth characteristics and estimates the spatial distribution of tumor cells in normal appearing regions of the brain. The target volume for radiotherapy planning can be defined as an isoline of the simulated tumor cell density. This paper analyzes the model with respect to implications for target volume definition and identifies its most critical components. A retrospective study involving ten glioblastoma patients treated at our institution has been performed. To illustrate the main findings of the study, a detailed case study is presented for a glioblastoma located close to the falx. In this situation, the falx represents a boundary for migrating tumor cells, whereas the corpus callosum provides a route for the tumor to spread to the contralateral hemisphere. We further discuss the sensitivity of the model with respect to the input parameters. Correct segmentation of the brain appears to be the most

  7. Planning volunteer responses to low-volume mass gatherings: do event characteristics predict patient workload?

    PubMed

    Woodall, John; Watt, Kerrianne; Walker, Damien; Tippett, Vivienne; Enraght-Moony, Emma; Bertolo, Chris; Mildwaters, Brett; Morrison, Glen

    2010-01-01

    Workforce planning for first aid and medical coverage of mass gatherings is hampered by limited research. In particular, the characteristics and likely presentation patterns of low-volume mass gatherings of between several hundred to several thousand people are poorly described in the existing literature. This study was conducted to: 1. Describe key patient and event characteristics of medical presentations at a series of mass gatherings, including events smaller than those previously described in the literature; 2. Determine whether event type and event size affect the mean number of patients presenting for treatment per event, and specifically, whether the 1:2,000 deployment rule used by St John Ambulance Australia is appropriate; and 3. Identify factors that are predictive of injury at mass gatherings. A retrospective, observational, case-series design was used to examine all cases treated by two Divisions of St John Ambulance (Queensland) in the greater metropolitan Brisbane region over a three-year period (01 January 2002-31 December 2004). Data were obtained from routinely collected patient treatment forms completed by St John officers at the time of treatment. Event-related data (e.g., weather, event size) were obtained from event forms designed for this study. Outcome measures include: total and average number of patient presentations for each event; event type; and event size category. Descriptive analyses were conducted using chi-square tests, and mean presentations per event and event type were investigated using Kruskal-Wallis tests. Logistic regression analyses were used to identify variables independently associated with injury presentation (compared with non-injury presentations). Over the three-year study period, St John Ambulance officers treated 705 patients over 156 separate events. The mean number of patients who presented with any medical condition at small events (less than or equal to 2,000 attendees) did not differ significantly from that of

  8. Data-Driven Approach to Generating Achievable Dose-Volume Histogram Objectives in Intensity-Modulated Radiotherapy Planning

    SciTech Connect

    Wu Binbin; Ricchetti, Francesco; Sanguineti, Giuseppe; Kazhdan, Michael; Simari, Patricio; Jacques, Robert; Taylor, Russell; McNutt, Todd

    2011-03-15

    Purpose: To propose a method of intensity-modulated radiotherapy (IMRT) planning that generates achievable dose-volume histogram (DVH) objectives using a database containing geometric and dosimetric information of previous patients. Methods and Materials: The overlap volume histogram (OVH) is used to compare the spatial relationships between the organs at risk and targets of a new patient with those of previous patients in a database. From the OVH analysis, the DVH objectives of the new patient were generated from the database and used as the initial planning goals. In a retrospective OVH-assisted planning demonstration, 15 patients were randomly selected from a database containing clinical plans (CPs) of 91 previous head-and-neck patients treated by a three-level IMRT-simultaneous integrated boost technique. OVH-assisted plans (OPs) were planned in a leave-one-out manner by a planner who had no knowledge of CPs. Thus, DVH objectives of an OP were generated from a subdatabase containing the information of the other 90 patients. Those DVH objectives were then used as the initial planning goals in IMRT optimization. Planning efficiency was evaluated by the number of clicks of the 'Start Optimization' button in the course of planning. Although the Pinnacle{sup 3} treatment planning system allows planners to interactively adjust the DVH parameters during optimization, planners in our institution have never used this function in planning. Results: The average clicks required for completing the CP and OP was 27.6 and 1.9, respectively (p <.00001); three OPs were finished within a single click. Ten more patient's cord + 4 mm reached the sparing goal D{sub 0.1cc} <44 Gy (p <.0001), where D{sub 0.1cc} represents the dose corresponding to 0.1 cc. For planning target volume uniformity, conformity, and other organ at risk sparing, the OPs were at least comparable with the CPs. Additionally, the averages of D{sub 0.1cc} to the cord + 4 mm decreased by 6.9 Gy (p <.0001

  9. Sparsity constrained split feasibility for dose-volume constraints in inverse planning of intensity-modulated photon or proton therapy

    NASA Astrophysics Data System (ADS)

    Penfold, Scott; Zalas, Rafał; Casiraghi, Margherita; Brooke, Mark; Censor, Yair; Schulte, Reinhard

    2017-05-01

    A split feasibility formulation for the inverse problem of intensity-modulated radiation therapy treatment planning with dose-volume constraints included in the planning algorithm is presented. It involves a new type of sparsity constraint that enables the inclusion of a percentage-violation constraint in the model problem and its handling by continuous (as opposed to integer) methods. We propose an iterative algorithmic framework for solving such a problem by applying the feasibility-seeking CQ-algorithm of Byrne combined with the automatic relaxation method that uses cyclic projections. Detailed implementation instructions are furnished. Functionality of the algorithm was demonstrated through the creation of an intensity-modulated proton therapy plan for a simple 2D C-shaped geometry and also for a realistic base-of-skull chordoma treatment site. Monte Carlo simulations of proton pencil beams of varying energy were conducted to obtain dose distributions for the 2D test case. A research release of the Pinnacle 3 proton treatment planning system was used to extract pencil beam doses for a clinical base-of-skull chordoma case. In both cases the beamlet doses were calculated to satisfy dose-volume constraints according to our new algorithm. Examination of the dose-volume histograms following inverse planning with our algorithm demonstrated that it performed as intended. The application of our proposed algorithm to dose-volume constraint inverse planning was successfully demonstrated. Comparison with optimized dose distributions from the research release of the Pinnacle 3 treatment planning system showed the algorithm could achieve equivalent or superior results.

  10. The Regents Statewide Plan for the Development of Postsecondary Education in New York State, 1988. Volume II.

    ERIC Educational Resources Information Center

    New York State Education Dept., Albany.

    This second volume of the statewide plan contains reports on: (1) postsecondary student enrollments, focusing on historical trends and demographic projections, enrollment projections, projection assumptions, and implications; (2) participation of minority students at the undergraduate level, participation of minorities and women in…

  11. Integrated operations plan for the MFTF-B Mirror Fusion Test Facility. Volume II. Integrated operations plan

    SciTech Connect

    Not Available

    1981-12-01

    This document defines an integrated plan for the operation of the Lawrence Livermore National Laboratory (LLNL) Mirror Fusion Test Facility (MFTF-B). The plan fulfills and further delineates LLNL policies and provides for accomplishing the functions required by the program. This plan specifies the management, operations, maintenance, and engineering support responsibilities. It covers phasing into sustained operations as well as the sustained operations themselves. Administrative and Plant Engineering support, which are now being performed satisfactorily, are not part of this plan unless there are unique needs.

  12. Savannah River Site mixed waste Proposed Site Treatment Plan (PSTP). Volumes 1 and 2 and reference document: Revision 2

    SciTech Connect

    Helmich, E.; Noller, D.K.; Wierzbicki, K.S.; Bailey, L.L.

    1995-07-13

    The DOE is required by the Resource Conservation and Recovery Act to prepare site treatment plans describing the development of treatment capacities and technologies for treating mixed waste. This proposed plan contains Savannah River Site`s preferred options and schedules for constructing new facilities, and otherwise obtaining treatment for mixed wastes. The proposed plan consists of 2 volumes. Volume 1, Compliance Plan, identifies the capacity to be developed and the schedules as required. Volume 2, Background, provides a detailed discussion of the preferred options with technical basis, plus a description of the specific waste streams. Chapters are: Introduction; Methodology; Mixed low level waste streams; Mixed transuranic waste; High level waste; Future generation of mixed waste streams; Storage; Process for evaluation of disposal issues in support of the site treatment plans discussions; Treatment facilities and treatment technologies; Offsite waste streams for which SRS treatment is the Preferred Option (Naval reactor wastes); Summary information; and Acronyms and glossary. This revision does not contain the complete revised report, but only those pages that have been revised.

  13. ICPP tank farm closure study. Volume 3: Cost estimates, planning schedules, yearly cost flowcharts, and life-cycle cost estimates

    SciTech Connect

    1998-02-01

    This volume contains information on cost estimates, planning schedules, yearly cost flowcharts, and life-cycle costs for the six options described in Volume 1, Section 2: Option 1 -- Total removal clean closure; No subsequent use; Option 2 -- Risk-based clean closure; LLW fill; Option 3 -- Risk-based clean closure; CERCLA fill; Option 4 -- Close to RCRA landfill standards; LLW fill; Option 5 -- Close to RCRA landfill standards; CERCLA fill; and Option 6 -- Close to RCRA landfill standards; Clean fill. This volume is divided into two portions. The first portion contains the cost and planning schedule estimates while the second portion contains life-cycle costs and yearly cash flow information for each option.

  14. Guidelines for Analysis of Pharmaceutical Supply System Planning in Developing Countries. Volume 7: Pharmaceutical Supply System Planning. International Health Planning Methods Series.

    ERIC Educational Resources Information Center

    Schaumann, Leif; And Others

    Intended to assist Agency for International Development (AID) officers, advisors, and health officials in incorporating health planning into national plans for economic development, this seventh of ten manuals in the Interational Health Planning Methods Series deals with pharmaceutical supply systems planning in developing countries. Following an…

  15. Guidelines for Analysis of Communicable Disease Control Planning in Developing Countries. Volume 1: Communicable Diseases Control Planning. International Health Planning Methods Series.

    ERIC Educational Resources Information Center

    Chin, James

    Intended to assist Agency for International Development (AID) officers, advisors, and health officials in incorporating health planning into national plans for economic development, this first of ten manuals in the International Health Planning Methods Series deals with planning and evaluation of communicable disease control programs. The first…

  16. Guidelines for Analysis of Pharmaceutical Supply System Planning in Developing Countries. Volume 7: Pharmaceutical Supply System Planning. International Health Planning Methods Series.

    ERIC Educational Resources Information Center

    Schaumann, Leif; And Others

    Intended to assist Agency for International Development (AID) officers, advisors, and health officials in incorporating health planning into national plans for economic development, this seventh of ten manuals in the Interational Health Planning Methods Series deals with pharmaceutical supply systems planning in developing countries. Following an…

  17. Guidelines for Analysis of Communicable Disease Control Planning in Developing Countries. Volume 1: Communicable Diseases Control Planning. International Health Planning Methods Series.

    ERIC Educational Resources Information Center

    Chin, James

    Intended to assist Agency for International Development (AID) officers, advisors, and health officials in incorporating health planning into national plans for economic development, this first of ten manuals in the International Health Planning Methods Series deals with planning and evaluation of communicable disease control programs. The first…

  18. Development and Production Leading to a Television Series on Parent Education: Planning Report. Volume II. Operational Plan.

    ERIC Educational Resources Information Center

    Applied Management Sciences, Inc., Silver Spring, MD.

    Processes are described which were used to continue the planning necessary for the production of a 20 episode educational television series for parent education. Dramatic episodes showing conflict in the lives of five fictional families form the basis for the planned series which is intended to educate 17-25-year-old parents to facilitate the…

  19. U.S. Department of Education FY 2000 Annual Plan, Volume 1: Objective Performance Plans and Data Quality.

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC.

    This annual plan identifies the key strategies and performance measures for the Department of Education (ED). The plan focuses on strategies for achieving the ED's mission, which is to ensure equal access to education and to promote educational excellence, and it discusses the department's four goals that support this mission: (1) help all…

  20. University of California, Irvine, Student Affirmative Action Five-Year Plan and Planning Process, 1985-1986. Volume III.

    ERIC Educational Resources Information Center

    Galligani, Dennis J.

    An update of the University of California, Irvine, Student Affirmative Action (SAA) plan is presented for 1985-1986. SAA activities planned by both academic and administrative units are covered, such as activities designed to: stimulate greater student involvement, establish clearer life goals and career linkages, enhance cultural awareness, and…

  1. A Beam-Specific Planning Target Volume (PTV) Design for Proton Therapy to Account for Setup and Range Uncertainties

    SciTech Connect

    Park, Peter C.; Zhu, X. Ronald; Lee, Andrew K.; Sahoo, Narayan; Melancon, Adam D.; Zhang Lifei; Dong Lei

    2012-02-01

    Purpose: To report a method for explicitly designing a planning target volume (PTV) for treatment planning and evaluation in heterogeneous media for passively scattered proton therapy and scanning beam proton therapy using single-field optimization (SFO). Methods and Materials: A beam-specific PTV (bsPTV) for proton beams was derived by ray-tracing and shifting ray lines to account for tissue misalignment in the presence of setup error or organ motion. Range uncertainties resulting from inaccuracies in computed tomography-based range estimation were calculated for proximal and distal surfaces of the target in the beam direction. The bsPTV was then constructed based on local heterogeneity. The bsPTV thus can be used directly as a planning target as if it were in photon therapy. To test the robustness of the bsPTV, we generated a single-field proton plan in a virtual phantom. Intentional setup and range errors were introduced. Dose coverage to the clinical target volume (CTV) under various simulation conditions was compared between plans designed based on the bsPTV and a conventional PTV. Results: The simulated treatment using the bsPTV design performed significantly better than the plan using the conventional PTV in maintaining dose coverage to the CTV. With conventional PTV plans, the minimum coverage to the CTV dropped from 99% to 67% in the presence of setup error, internal motion, and range uncertainty. However, plans using the bsPTV showed minimal drop of target coverage from 99% to 94%. Conclusions: The conventional geometry-based PTV concept used in photon therapy does not work well for proton therapy. We investigated and validated a beam-specific PTV method for designing and evaluating proton plans.

  2. Education as Experimentation: A Planned Variation Model. Volume IIIA: Findings: Cohort II; Interim Findings: Cohort III. Volume IIIB: Appendices.

    ERIC Educational Resources Information Center

    Stebbins, Linda B.; And Others

    This segment of the national evaluation study of the Follow Through Planned Variation Model reviews the background of the study, describes 13 of the Follow Through models involved, and presents an analysis of the effects of these models on students. The analysis is based on data from 4 years of Follow Through participation by Cohort II children…

  3. Sci-Thur AM: Planning - 06: Planning target volume margin suitability in lung stereotactic body radiation therapy: A preliminary evaluation using cone-beam computed tomography.

    PubMed

    Mathew, L; Swaminath, A; Szabo, J; Wierzbicki, M

    2012-07-01

    Stereotactic body radiation therapy (SBRT) requires precise delivery of radiation to the target; intra- and inter-fraction lung tumour motion may adversely impact local tumour control. The purpose of this study was to retrospectively evaluate the impact of planning target volume (PTV) margin size on the coverage of the internal target volume (ITV) as localized in pre- and post-treatment cone-beam computed tomography (CBCT) images. Data from two patients undergoing SBRT were evaluated. For planning, free-breathing and 4DCT scans were performed, and used to contour the ITV. A 5mm margin was added to create the PTV. During treatment, 14 CBCTs were collected pre- and post-beam delivery. A data set comprising the average 4DCT intensities where available and treatment planning CT intensities for voxels that were beyond the field of view of the 4DCT was constructed. Registration of the combined planning image to each CBCT was performed using a deformable image registration algorithm. The transformations aligning the combined planning image with the CBCTs were applied to the planning ITV to obtain the treatment ITVs. For each CBCT, the fraction of treatment ITV within the PTV was determined using Boolean logic. This was repeated for various PTV margins ranging from 0 to 10 mm at 1mm intervals. The 3 and 5 mm PTV margins covered 95.1 ± 5.9% and 99.0 ± 2.0% of the ITV, respectively. Analysis of additional patients will be performed to confirm these preliminary results, which reinforce the use of a 5mm PTV margin for lung SBRT. © 2012 American Association of Physicists in Medicine.

  4. The benefit of using bladder sub-volume equivalent uniform dose constraints in prostate intensity-modulated radiotherapy planning

    PubMed Central

    Zhu, Jian; Simon, Antoine; Haigron, Pascal; Lafond, Caroline; Acosta, Oscar; Shu, Huazhong; Castelli, Joel; Li, Baosheng; De Crevoisier, Renaud

    2016-01-01

    Background To assess the benefits of bladder wall sub-volume equivalent uniform dose (EUD) constraints in prostate cancer intensity-modulated radiotherapy (IMRT) planning. Methods Two IMRT plans, with and without EUD constraints on the bladder wall, were generated using beams that deliver 80 Gy to the prostate and 46 Gy to the seminal vesicles and were compared in 53 prostate cancer patients. The bladder wall was defined as the volume between the external manually delineated wall and a contraction of 7 mm apart from it. The bladder wall was then separated into two parts: the internal-bladder wall (bla-in) represented by the portion of the bladder wall that intersected with the planning target volume (PTV) plus 5 mm extension; the external-bladder wall (bla-ex) represented by the remaining part of the bladder wall. In the IMRT plan with EUD constraints, the values of “a” parameter for the EUD models were 10.0 for bla-in and 2.3 for bla-ex. The plans with and without EUD constraints were compared in terms of dose–volume histograms, 5-year bladder and rectum normal tissue complication probability values, as well as tumor control probability (TCP) values. Results The use of bladder sub-volume EUD constraints decreased both the doses to the bladder wall (V70: 22.76% vs 19.65%, Dmean: 39.82 Gy vs 35.45 Gy) and the 5-year bladder complication probabilities (≥LENT/SOMA Grade 2: 20.35% vs 17.96%; bladder bleeding: 10.63% vs 8.64%). The doses to the rectum wall and the rectum complication probabilities were also slightly decreased by the EUD constraints compared to physical constraints only. The minimal dose and the V76Gy of PTVprostate were, however, slightly decreased by EUD optimization, nevertheless without significant difference in TCP values between the two plans, and the PTV parameters finally respected the Groupe d’Etude des Tumeurs Uro-Génitales recommendations. Conclusion Separating the bladder wall into two parts with appropriate EUD optimization may

  5. Test Plans and Procedures for the Baseline SAF for BDS-D Sites (ModSAF). Volume 2

    DTIC Science & Technology

    1993-12-20

    1. AGENCY USE ONLY (Leave blank) j 2REPORT DATE 3 . REPORT TYPE AND DATES COVEREDUI 4. TITLE AND SUBTITLE 05. FUNDING NUMBERS Test Plans and Procedures...Praed by ANSI Sid Z39-18 298-102 ADST/WDL/TR-93-W003271 VOLUME 2 of 2; Ver 1.0 3 TEST CASE 1.1 Architecture STEP OPERATOR/SYSTEM ACTION EXPECTED RESULT...8217 I< I ’or SDis ft ADST/WDL/TR-93-W003271 VOLUME 2 of 2; Ver 1.0 3 TEST CASE 1.2 Configuration STEP OPERATOR/SYSTEM ACTION EXPECTED RESULT STATUS S SA

  6. Defining the Clinical Target Volume for Bladder Cancer Radiotherapy Treatment Planning

    SciTech Connect

    Jenkins, Peter; Anjarwalla, Salim; Gilbert, Hugh; Kinder, Richard

    2009-12-01

    Purpose: There are currently no data for the expansion margin required to define the clinical target volume (CTV) around bladder tumors. This information is particularly relevant when perivesical soft tissue changes are seen on the planning scan. While this appearance may reflect extravesical extension (EVE), it may also be an artifact of previous transurethral resection (TUR). Methods and Materials: Eighty patients with muscle-invasive bladder cancer who had undergone radical cystectomy were studied. All patients underwent preoperative TUR and staging computed tomography (CT) scans. The presence and extent of tumor growth beyond the outer bladder wall was measured radiologically and histopathologically. Results: Forty one (51%) patients had histologically confirmed tumor extension into perivesical fat. The median and mean extensions beyond the outer bladder wall were 1.7 and 3.1 mm, respectively. Thirty five (44%) patients had EVE, as seen on CT scans. The sensitivity and specificity of CT scans for EVE were 56% and 79%, respectively. False-positive results were infrequent and not affected by either the timing or the amount of tissue resected at TUR. CT scans consistently tended to overestimate the extent of EVE. Tumor size and the presence of either lymphovascular invasion or squamoid differentiation predict a greater extent of EVE. Conclusions: In patients with radiological evidence of extravesical disease, the CTV should comprise the outer bladder wall plus a 10-mm margin. In patients with no evidence of extravesical disease on CT scans, the CTV should be restricted to the outer bladder wall plus a 6-mm margin. These recommendations would encompass microscopic disease extension in 90% of cases.

  7. Space Station Mission Planning System (MPS) development study. Volume 1: Executive summary

    NASA Technical Reports Server (NTRS)

    Klus, W. J.

    1987-01-01

    The basic objective of the Space Station (SS) Mission Planning System (MPS) Development Study was to define a baseline Space Station mission plan and the associated hardware and software requirements for the system. A detailed definition of the Spacelab (SL) payload mission planning process and SL Mission Integration Planning System (MIPS) software was derived. A baseline concept was developed for performing SS manned base payload mission planning, and it was consistent with current Space Station design/operations concepts and philosophies. The SS MPS software requirements were defined. Also, requirements for new software include candidate programs for the application of artificial intelligence techniques to capture and make more effective use of mission planning expertise. A SS MPS Software Development Plan was developed which phases efforts for the development software to implement the SS mission planning concept.

  8. The 30/20 GHz flight experiment system, phase 2. Volume 4: Experiment system development plan

    NASA Technical Reports Server (NTRS)

    Bronstein, L.; Kawamoto, Y.; Riberich, J. J.; Scope, J. R.; Forman, B. J.; Bergman, S. G.; Reisenfeld, S.

    1981-01-01

    The development plan for the 30/20 GHz flight experiment system is presented. A master program schedule with detailed development plans for each subsystem is planned with careful attention given to how technology items to ensure a minimal risk. The work breakdown structure shows the organization of the program management with detailed task definitions. The ROM costs based on the development plan are also given.

  9. Scheduling language and algorithm development study. Volume 2, phase 2: Introduction to plans programming. [user guide

    NASA Technical Reports Server (NTRS)

    Cochran, D. R.; Ishikawa, M. K.; Paulson, R. E.; Ramsey, H. R.

    1975-01-01

    A user guide for the Programming Language for Allocation and Network Scheduling (PLANS) is presented. Information is included for the construction of PLANS programs. The basic philosophy of PLANS is discussed, and access and update reference techniques are described along with the use of tree structures.

  10. Manned Orbital Transfer Vehicle (MOTV). Volume 6: Five year program plan

    NASA Technical Reports Server (NTRS)

    Boyland, R. E.; Sherman, S. W.; Morfin, H. W.

    1979-01-01

    The five year program plan for the manned orbit transfer vehicle (MOTV) is presented. The planning, schedules, cost estimates, and supporting data (objectives, constraints, assumptions, etc.) associated with the development of the MOTV are discussed. The plan, in addition to the above material, identifies the supporting research and technology required to resolve issues critical to MOTV development.

  11. System design of the Pioneer Venus spacecraft. Volume 14: Test planning trades

    NASA Technical Reports Server (NTRS)

    Pedretti, C. D.

    1973-01-01

    Pioneer Venus system test plans and trade studies which were first published as Study Tasks (References 1 through 5) are reviewed. The plan and trade studies are presented in a condensed form. Greater detail may be found in the referenced study tasks if desired. All significant conclusions and plan outlines of the original studies are, presented.

  12. University of California, Irvine, Student Affirmative Action Five-Year Plan and Planning Process, 1986-1987. Volume IV.

    ERIC Educational Resources Information Center

    Galligani, Dennis J.

    The University of California, Irvine, 1986-1987 Student Affirmative Action (SAA) Plan is presented. An introductory section covers the organizational structure of SAA efforts, progress toward SAA goals, persistence and graduation rates for new SAA high school freshmen through spring 1985, and an overview of SAA education-oriented and…

  13. Preoperative planning with magnetic resonance imaging and computerized volume rendering in twin-to-twin transfusion syndrome.

    PubMed

    Luks, F I; Carr, S R; Ponte, B; Rogg, J M; Tracy, T F

    2001-07-01

    Our purpose was to illustrate the feasibility of preoperative planning with magnetic resonance imaging, 3-dimensional reconstruction, and volume-rendering techniques in twin-to-twin transfusion syndrome treated by endoscopic laser ablation of communicating vessels. After ultrasonographic determination of the syndrome and the indications for intervention, 2 patients with an anterior placenta underwent magnetic resonance imaging without the need for maternal or fetal sedation. Raw image data were downloaded into a desktop computer and manipulated with 3-dimensional reconstruction, volume rendering, and surgical navigation software. In both patients a virtual rendering of the fetuses, placenta, and uterus could be manipulated to expose all sides, demonstrate the location of the intertwin membrane, and plan the point of entry and curve of the endoscopic instruments. Preoperative planning and virtual surgical navigation in fetal surgery are now possible, as a result of shorter magnetic resonance imaging acquisition times and volume-rendering software. In this manner an entire virtual endoscopic fetal operation can be performed and fine-tuned before the actual procedure is to take place.

  14. Systems design study of the Pioneer Venus spacecraft. Volume 2. Preliminary program development plan

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The preliminary development plan for the Pioneer Venus program is presented. This preliminary plan treats only developmental aspects that would have a significant effect on program cost. These significant development areas were: master program schedule planning; test planning - both unit and system testing for probes/orbiter/ probe bus; ground support equipment; performance assurance; and science integration Various test planning options and test method techniques were evaluated in terms of achieving a low-cost program without degrading mission performance or system reliability. The approaches studied and the methodology of the selected approach are defined.

  15. Project Columbiad: Mission to the Moon. Book 2, volume 3: Stage configuration designs; volume 4: Program plan

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The Earth Orbital Rendezvous (EOR) configuration for the piloted mission is composed of three propulsive elements in addition to the Crew Module (CM): Primary Trans-Lunar Injection (PTLI), Lunar Braking Module (LBM), and Earth Return Module (ERM). The precursor mission is also composed of three propulsive elements in addition to its surface payloads: PTLI, LBM and the Payload Landing Module (PLM). Refer to Volume 1, Section 5.1 and 5.2 for a break-up of the different stages into the four launches. A quick summary is as follows: PTLI is on Launch 1 and 3 while the LBM, PLM, and surface payloads are on Launch 2 and another LBM, ERM, and CM on Launch 4. The precursor mission is designed to be as modular as possible with the piloted mission for developmental cost considerations. The following topics are discussed: launch vehicle description; primary trans-lunar injection stage; lunar braking module; earth return module; crew module; payload landing module; and surface payload description.

  16. Respiratory-gated (4D) contrast-enhanced FDG PET-CT for radiotherapy planning of lower oesophageal carcinoma: feasibility and impact on planning target volume.

    PubMed

    Scarsbrook, Andrew; Ward, Gillian; Murray, Patrick; Goody, Rebecca; Marshall, Karen; McDermott, Garry; Prestwich, Robin; Radhakrishna, Ganesh

    2017-10-04

    To assess the feasibility and potential impact on target delineation of respiratory-gated (4D) contrast-enhanced (18)Fluorine fluorodeoxyglucose (FDG) positron emission tomography - computed tomography (PET-CT), in the treatment planning position, for a prospective cohort of patients with lower third oesophageal cancer. Fifteen patients were recruited into the study. Imaging included 4D PET-CT, 3D PET-CT, endoscopic ultrasound and planning 4D CT. Target volume delineation was performed on 4D CT, 4D CT with co-registered 3D PET and 4D PET-CT. Planning target volumes (PTV) generated with 4D CT (PTV4DCT), 4D CT co-registered with 3D PET-CT (PTV3DPET4DCT) and 4D PET-CT (PTV4DPETCT) were compared with multiple positional metrics. Mean PTV4DCT, PTV3DPET4DCT and PTV4DPETCT were 582.4 ± 275.1 cm(3), 472.5 ± 193.1 cm(3) and 480.6 ± 236.9 cm(3) respectively (no significant difference). Median DICE similarity coefficients comparing PTV4DCT with PTV3DPET4DCT, PTV4DCT with PTV4DPETCT and PTV3DPET4DCT with PTV4DPETCT were 0.85 (range 0.65-0.9), 0.85 (range 0.69-0.9) and 0.88 (range 0.79-0.9) respectively. The median sensitivity index for overlap comparing PTV4DCT with PTV3DPET4DCT, PTV4DCT with PTV4DPETCT and PTV3DPET4DCT with PTV4DPETCT were 0.78 (range 0.65-0.9), 0.79 (range 0.65-0.9) and 0.89 (range 0.68-0.94) respectively. Planning 4D PET-CT is feasible with careful patient selection. PTV generated using 4D CT, 3D PET-CT and 4D PET-CT were of similar volume, however, overlap analysis demonstrated that approximately 20% of PTV3DPETCT and PTV4DPETCT are not included in PTV4DCT, leading to under-coverage of target volume and a potential geometric miss. Additionally, differences between PTV3DPET4DCT and PTV4DPETCT suggest a potential benefit for 4D PET-CT. ClinicalTrials.gov Identifier - NCT02285660 (Registered 21/10/2014).

  17. Organizational Behavior in Disasters and Implications for Disaster Planning. Volume 1, Number 2

    DTIC Science & Technology

    1986-07-01

    Disaster Research Center Ohio State University National Emergency Training Center Emmitsburg, Maryland MONOGRAPH SERIES 1984 A VoIu’c NMober 2 "UIO ns1~e A... emergency . Disaster planning can be effective, if done properly. A disaster plan, when implemented, will reflect what was put into it. Thus, if such a...applicable to all disaster types. This monograph is designed for emergency management professionals having disaster preparedness planning

  18. SSTAC/ARTS review of the draft Integrated Technology Plan (ITP). Volume 6: Controls and guidance

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Viewgraphs of briefings from the Space Systems and Technology Advisory Committee (SSTAC)/ARTS review of the draft Integrated Technology Plan (ITP) on controls and guidance are included. Topics covered include: strategic avionics technology planning and bridging programs; avionics technology plan; vehicle health management; spacecraft guidance research; autonomous rendezvous and docking; autonomous landing; computational control; fiberoptic rotation sensors; precision instrument and telescope pointing; microsensors and microinstruments; micro guidance and control initiative; and earth-orbiting platforms controls-structures interaction.

  19. Elective breast radiotherapy including level I and II lymph nodes: A planning study with the humeral head as planning risk volume.

    PubMed

    Surmann, Kathrin; van der Leer, Jorien; Branje, Tammy; van der Sangen, Maurice; van Lieshout, Maarten; Hurkmans, Coen W

    2017-01-18

    The aim of this study was to assess the dose to the humeral head planning risk volume with the currently used high tangential fields (HTF) and compare different planning techniques for breast radiotherapy including axillary level I and II lymph nodes (PTVn) while sparing the humeral head. Ten patients with left-sided breast cancer were enrolled in a planning study with 16 fractions of 2.66 Gy. Four planning techniques were compared: HTF, HTF with sparing of the humeral head, 6-field IMRT with sparing of the humeral head and VMAT with sparing of the humeral head. The humeral head + 10 mm was spared by restricting V40Gy < 1 cc. The dose to the humeral head was too high with HTF (V40Gy on average 20.7 cc). When sparing the humeral head in HTF, PTVn V90% decreased significantly from 97.9% to 89.4%. 6-field IMRT and VMAT had a PTVn V90% of 98.2% and 99.5% respectively. However, dose to the lungs, heart and especially the contralateral breast increased with VMAT. The humeral head is rarely spared when using HTF. When sparing the humeral head, the 6-field IMRT technique leads to adequate PTV coverage while not increasing the dose to the OARs.

  20. SU-E-T-379: Concave Approximations of Target Volume Dose Metrics for Intensity- Modulated Radiotherapy Treatment Planning

    SciTech Connect

    Xie, Y; Chen, Y; Wickerhauser, M; Deasy, J

    2014-06-01

    Purpose: The widely used treatment plan metric Dx (mimimum dose to the hottest x% by volume of the target volume) is simple to interpret and use, but is computationally poorly behaved (non-convex), this impedes its use in computationally efficient intensity-modulated radiotherapy (IMRT) treatment planning algorithms. We therefore searched for surrogate metrics that are concave, computationally efficient, and accurately correlated to Dx values in IMRT treatment plans. Methods: To find concave surrogates of D95—and more generally, Dx values with variable x values—we tested equations containing one or two generalized equivalent uniform dose (gEUD) functions. Fits were obtained by varying gEUD ‘a’ parameter values, as well as the linear equation coefficients. Fitting was performed using a dataset of dose-volume histograms from 498 de-identified head and neck IMRT treatment plans. Fit characteristics were tested using a crossvalidation process. Reported root-mean-square error values were averaged over the cross-validation shuffles. Results: As expected, the two-gEUD formula provided a superior fit, compared to the single-gEUD formula. The best approximation uses two gEUD terms: 16.25 x gEUD[a=0.45] – 15.30 x gEUD[a=1.75] – 0.69. The average root-mean-square error on repeated (70/30) cross validation was 0.94 Gy. In addition, a formula was found that reasonably approximates Dx for x between 80% and 96%. Conclusion: A simple concave function using two gEUD terms was found that correlates well with PTV D95s for these head and neck treatment plans. More generally, a formula was found that represents well the Dx for x values from 80% to 96%, thus providing a computationally efficient formula for use in treatment planning optimization. The formula may need to be adjusted for other institutions with different treatment planning protocols. We conclude that the strategy of replacing Dx values with gEUD-based formulas is promising.

  1. Liquid rocket booster study. Volume 2, book 3, appendices 2-5: PPIP, transition plan, AMOS plan, and environmental analysis

    NASA Technical Reports Server (NTRS)

    1988-01-01

    This Preliminary Project Implementation Plan (PPIP) was used to examine the feasibility of replacing the current Solid Rocket Boosters on the Space Shuttle with Liquid Rocket Boosters (LRBs). The need has determined the implications of integrating the LRB with the Space Transportation System as the earliest practical date. The purpose was to identify and define all elements required in a full scale development program for the LRB. This will be a reference guide for management of the LRB program, addressing such requirement as design and development, configuration management, performance measurement, manufacturing, product assurance and verification, launch operations, and mission operations support.

  2. Closure plan for Solid Waste Storage Area 6: Volume 1, Closure plan. Remedial investigation/feasibility study

    SciTech Connect

    Not Available

    1988-09-01

    This Closure Plan for Solid Waste Storage Area 6 (SWSA 6) a disposal area for low-level radioactive wastes and hazardous materials, of the US Department of Energy (DOE) Oak Ridge National Laboratory (ORNL) describes how portions of SWSA 6 will be closed under Resource Conservation and Recovery Act (RCRA) Interim Status per 40 CFR 265 Subpart G [TN Rule 1200-1-11-.05(7)]. An overview is provided of activities necessary for final closure and corrective measures for all of SWSA 6. Results of surface waters and groundwater sampling are provided.

  3. Community College Journal for Research and Planning; Volume 4, Numbers 1-2.

    ERIC Educational Resources Information Center

    Carter, Edith H., Ed.

    1985-01-01

    Designed as a forum for the exchange of information among members of the National Council for Research and Planning, these two journal issues offer 10 articles concerning community college research and planning. The first issue presents: (1) "Just Testing," by Arthur M. Cohen; (2) "Enrollment Patterns of Adult Learning in a Community College," by…

  4. Space shuttle program: Shuttle Avionics Integration Laboratory. Volume 7: Logistics management plan

    NASA Technical Reports Server (NTRS)

    1974-01-01

    The logistics management plan for the shuttle avionics integration laboratory defines the organization, disciplines, and methodology for managing and controlling logistics support. Those elements requiring management include maintainability and reliability, maintenance planning, support and test equipment, supply support, transportation and handling, technical data, facilities, personnel and training, funding, and management data.

  5. Mod-2 wind turbine system cluster research test program. Volume 1: Initial plan E-1290

    NASA Technical Reports Server (NTRS)

    Gordon, L. H.

    1982-01-01

    Upon completion of the design and development of three Mod-2 wind turbines, a series of research experiments are planned to gather data on and evaluate the performance, environmental effects, and operation of a cluster as well as a single, large multimegawatt wind turbine. Information on the program objectives, a Mod-2 system description, a planned schedule, organizational roles, and responsibilities, is included.

  6. Sociopolitical Perspectives on Language Policy and Planning in the USA. Studies in Bilingualism, Volume 16.

    ERIC Educational Resources Information Center

    Huebner, Thom, Ed.; Davis, Kathryn A., Ed.

    This monograph includes a collection of papers that are an outgrowth of a colloquium on socio-political dimensions of language policy and language planning held at the 1997 American Association of Applied Linguistics Conference. Section 1, "Language Policy/Planning Frameworks," includes: (1) "Sociopolitical Perspectives on Language…

  7. Training Materials. A Vocational Education Planning System for Local School Districts. Volume VIII.

    ERIC Educational Resources Information Center

    Government Studies & Systems, Philadelphia, PA.

    The manual, one of several resulting from a project to design planning procedures for local and State vocational education agencies, contains a variety of materials used in workshops, orientations, and briefings during the development of the Vocational Education Planning System. Two sections are particularly detailed: An Approach to the Vocational…

  8. Clinical implementation of dose-volume histogram predictions for organs-at-risk in IMRT planning

    NASA Astrophysics Data System (ADS)

    Moore, K. L.; Appenzoller, L. M.; Tan, J.; Michalski, J. M.; Thorstad, W. L.; Mutic, S.

    2014-03-01

    True quality control (QC) of the planning process requires quantitative assessments of treatment plan quality itself, and QC in IMRT has been stymied by intra-patient anatomical variability and inherently complex three-dimensional dose distributions. In this work we describe the development of an automated system to reduce clinical IMRT planning variability and improve plan quality using mathematical models that predict achievable OAR DVHs based on individual patient anatomy. These models rely on the correlation of expected dose to the minimum distance from a voxel to the PTV surface, whereby a three-parameter probability distribution function (PDF) was used to model iso-distance OAR subvolume dose distributions. DVH models were obtained by fitting the evolution of the PDF with distance. Initial validation on clinical cohorts of 40 prostate and 24 head-and-neck plans demonstrated highly accurate model-based predictions for achievable DVHs in rectum, bladder, and parotid glands. By quantifying the integrated difference between candidate DVHs and predicted DVHs, the models correctly identified plans with under-spared OARs, validated by replanning all cases and correlating any realized improvements against the predicted gains. Clinical implementation of these predictive models was demonstrated in the PINNACLE treatment planning system by use of existing margin expansion utilities and the scripting functionality inherent to the system. To maintain independence from specific planning software, a system was developed in MATLAB to directly process DICOM-RT data. Both model training and patient-specific analyses were demonstrated with significant computational accelerations from parallelization.

  9. Study of solid rocket motor for space shuttle booster, Volume 3: Program acquisition planning

    NASA Technical Reports Server (NTRS)

    1972-01-01

    The program planning acquisition functions for the development of the solid propellant rocket engine for the space shuttle booster is presented. The subjects discussed are: (1) program management, (2) contracts administration, (3) systems engineering, (4) configuration management, and (5) maintenance engineering. The plans for manufacturing, testing, and operations support are included.

  10. Alaska Statewide Plan for Postsecondary Education, 1986-1990: A Draft for Public Comment. Volume I.

    ERIC Educational Resources Information Center

    Alaska State Commission on Postsecondary Education, Juneau.

    This report, the first statewide master plan for postsecondary education in Alaska, outlines strategies and recommendations to achieve the following planning goals: (1) promote excellence to improve educational service; (2) enhance accountability of the educational process; (3) foster efficiency within the enterprise; and (4) improve access to…

  11. Dose-Volume Differences for Computed Tomography and Magnetic Resonance Imaging Segmentation and Planning for Proton Prostate Cancer Therapy

    SciTech Connect

    Yeung, Anamaria R.; Vargas, Carlos E. Falchook, Aaron; Louis, Debbie C.; Olivier, Kenneth; Keole, Sameer; Yeung, Daniel; Mendenhall, Nancy P.; Li Zuofeng

    2008-12-01

    Purpose: To determine the influence of magnetic-resonance-imaging (MRI)-vs. computed-tomography (CT)-based prostate and normal structure delineation on the dose to the target and organs at risk during proton therapy. Methods and Materials: Fourteen patients were simulated in the supine position using both CT and T2 MRI. The prostate, rectum, and bladder were delineated on both imaging modalities. The planning target volume (PTV) was generated from the delineated prostates with a 5-mm axial and 8-mm superior and inferior margin. Two plans were generated and analyzed for each patient: an MRI plan based on the MRI-delineated PTV, and a CT plan based on the CT-delineated PTV. Doses of 78 Gy equivalents (GE) were prescribed to the PTV. Results: Doses to normal structures were lower when MRI was used to delineate the rectum and bladder compared with CT: bladder V50 was 15.3% lower (p = 0.04), and rectum V50 was 23.9% lower (p = 0.003). Poor agreement on the definition of the prostate apex was seen between CT and MRI (p = 0.007). The CT-defined prostate apex was within 2 mm of the apex on MRI only 35.7% of the time. Coverage of the MRI-delineated PTV was significantly decreased with the CT-based plan: the minimum dose to the PTV was reduced by 43% (p < 0.001), and the PTV V99% was reduced by 11% (p < 0.001). Conclusions: Using MRI to delineate the prostate results in more accurate target definition and a smaller target volume compared with CT, allowing for improved target coverage and decreased doses to critical normal structures.

  12. Acute small bowel toxicity and preoperative chemoradiotherapy for rectal cancer: Investigating dose-volume relationships and role for inverse planning

    SciTech Connect

    Tho, Lye Mun . E-mail: l.tho@beatson.gla.ac.uk; Glegg, Martin; Paterson, Jennifer; Yap, Christina; MacLeod, Alice; McCabe, Marie; McDonald, Alexander C.

    2006-10-01

    Purpose: The relationship between volume of irradiated small bowel (VSB) and acute toxicity in rectal cancer radiotherapy is poorly quantified, particularly in patients receiving concurrent preoperative chemoradiotherapy. Using treatment planning data, we studied a series of such patients. Methods and Materials: Details of 41 patients with locally advanced rectal cancer were reviewed. All received 45 Gy in 25 fractions over 5 weeks, 3-4 fields three-dimensional conformal radiotherapy with daily 5-fluorouracil and folinic acid during Weeks 1 and 5. Toxicity was assessed prospectively in a weekly clinic. Using computed tomography planning software, the VSB was determined at 5 Gy dose intervals (V{sub 5}, V{sub 1}, etc.). Eight patients with maximal VSB had dosimetry and radiobiological modeling outcomes compared between inverse and conformal three-dimensional planning. Results: VSB correlated strongly with diarrheal severity at every dose level (p < 0.03), with strongest correlation at lowest doses. Median VSB differed significantly between patients experiencing Grade 0-1 and Grade 2-4 diarrhea (p {<=} 0.05). No correlation was found with anorexia, nausea, vomiting, abdominal cramps, age, body mass index, sex, tumor position, or number of fields. Analysis of 8 patients showed that inverse planning reduced median dose to small bowel by 5.1 Gy (p = 0.008) and calculated late normal tissue complication probability (NTCP) by 67% (p = 0.016). We constructed a model using mathematical analysis to predict for acute diarrhea occurring at V{sub 5} and V{sub 15}. Conclusions: A strong dose-volume relationship exists between VSB and acute diarrhea at all dose levels during preoperative chemoradiotherapy. Our constructed model may be useful in predicting toxicity, and this has been derived without the confounding influence of surgical excision on bowel function. Inverse planning can reduce calculated dose to small bowel and late NTCP, and its clinical role warrants further

  13. Formal Methods Specification and Verification Guidebook for Software and Computer Systems. Volume 1; Planning and Technology Insertion

    NASA Technical Reports Server (NTRS)

    1995-01-01

    The Formal Methods Specification and Verification Guidebook for Software and Computer Systems describes a set of techniques called Formal Methods (FM), and outlines their use in the specification and verification of computer systems and software. Development of increasingly complex systems has created a need for improved specification and verification techniques. NASA's Safety and Mission Quality Office has supported the investigation of techniques such as FM, which are now an accepted method for enhancing the quality of aerospace applications. The guidebook provides information for managers and practitioners who are interested in integrating FM into an existing systems development process. Information includes technical and administrative considerations that must be addressed when establishing the use of FM on a specific project. The guidebook is intended to aid decision makers in the successful application of FM to the development of high-quality systems at reasonable cost. This is the first volume of a planned two-volume set. The current volume focuses on administrative and planning considerations for the successful application of FM.

  14. The Hippocampus Sparing Volume Modulated Arc Therapy does not Influence Plan Quality on Locally Advanced Nasopharyngeal Carcinoma Patients.

    PubMed

    Gu, Wendong; Li, Qilin; Xi, Dan; Tian, Ye; Mo, Juncong; Pei, Honglei

    2017-06-13

    Irradiation on hippocampus would lead to neuro-cognitive dysfunction in locally advanced nasopharyneal carcinoma (LA-NPC) patients accepting radiotherapy. Our study here aimed to investigate if undergoing hippocampus sparing (HS) volume modulated arc therapy (VMAT) would influence the plan quality in LA NPC patients. We designed three kinds of radiotherapeutic plans for 11 LA NPC patients: conventional VMAT (C-VMAT), HS-VMAT and HS intensity modulated radiation therapy with dynamic multileaf collimator (HS-dMLC). And the dose distribution on targets and surrounding organs at risk (OAR) were carefully evaluated. We found out that the expected doses on hippocampus were significantly lowered in HS-VMAT (899 ± 378 cGy) and HS-dMLC (896 ± 321 cGy) as compared to C-VMAT (1518 ± 337 cGy, p < 0.05), but meaningless difference was presented on plan quality of targets (p > 0.05). Moreover, lower radiation doses on brain stem were observed in HS-VMAT plan in comparison with C-VMAT plan (p < 0.05). However, there were no statistically meaningful diversities in the doses received by other OARs among all plans. Here we concluded that HS-VMAT presented promising advantages on protecting hipppcampus and brain stem as compared to C-VMAT and HS-dMLC, but enthusiastically had no effects on plan quality in LA-NPC patients.

  15. Final consolidated action plan to Tiger Team. Volume 1, Change 1

    SciTech Connect

    Not Available

    1993-04-01

    Two separate Tiger Team assessments were conducted at Sandia National Laboratories (SNL). The first was conducted at the California site in Livermore between April 30, 1990, and May 18, 1990. A second Tiger team assessment was conducted at the New Mexico site in Albuquerque between April 15 and May 24, 1991. One purpose of this Action Plan is to provide a formal written response to each of the findings and/or concerns cited in the SNL Tiger Team assessment reports. A second purpose is to present actions planned to be conducted to eliminate deficiencies identified by the Tiger Teams. A third purpose is to consolidate (group) related findings and to identify priorities assigned to the planned actions for improved efficiency and enhanced management of the tasks. A fourth and final purpose is to merge the two original SNL Action Plans for the New Mexico and California sites into a single Action Plan as a major step toward managing all SNL ES&H activities more similarly. Included in this combined SNL Action Plan are descriptions of the actions to be taken by SNL to liminate all problems identified in the Tiger Teams` findings/concerns, as well as estimated costs and schedules for planned actions.

  16. Satellite power systems (SPS) concept definition study. Volume 7: SPS program plan and economic analysis, appendixes

    NASA Technical Reports Server (NTRS)

    Hanley, G.

    1978-01-01

    Three appendixes in support of Volume 7 are contained in this document. The three appendixes are: (1) Satellite Power System Work Breakdown Structure Dictionary; (2) SPS cost Estimating Relationships; and (3) Financial and Operational Concept. Other volumes of the final report that provide additional detail are: Executive Summary; SPS Systems Requirements; SPS Concept Evolution; SPS Point Design Definition; Transportation and Operations Analysis; and SPS Technology Requirements and Verification.

  17. Manned space flight nuclear system safety. Volume 6: Space base nuclear system safety plan

    NASA Technical Reports Server (NTRS)

    1972-01-01

    A qualitative identification of the steps required to assure the incorporation of radiological system safety principles and objectives into all phases of a manned space base program are presented. Specific areas of emphasis include: (1) radiological program management, (2) nuclear system safety plan implementation, (3) impact on program, and (4) summary of the key operation and design guidelines and requirements. The plan clearly indicates the necessity of considering and implementing radiological system safety recommendations as early as possible in the development cycle to assure maximum safety and minimize the impact on design and mission plans.

  18. DNFSB Recommendation 94-1 Hanford Site Integrated Stabilization Management Plan. Volume 1

    SciTech Connect

    McCormack, R.L.

    1995-08-01

    This document describes the plans of the Hanford Site for the safe interim storage of fissile materials. Currently, spent nuclear fuels reside in storage basins that have leaked in the past and are projected to leak in the future. Other problems in the basins include; sludge from decomposition, degraded cladding of fuel elements, and construction defects which make the basins seismically unsafe. This management plan describes the time and cost that it will take to implement a safe interim storage plan for the fissile materials.

  19. Bioresearch module design definition and space shuttle vehicle integration. Volume 3: Management and funding plan

    NASA Technical Reports Server (NTRS)

    1971-01-01

    A description is given of the proposed project organization, documentation and reports, project planning, direction and control, related experience and facilities, and cost estimate data and options for the implementation of the bioresearch module development program.

  20. SSTAC/ARTS review of the draft Integrated Technology Plan (ITP). Volume 1: Plenary Session

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Briefings from the plenary session of the conference on SSTAC/ARTS Review of the Draft Integrated Technology Plan (ITP) held on 24-28 Jun. 1991 are included. Viewgraphs from the presentations are included.

  1. Space station systems technology study (add-on task). Volume 3: Technology advancement program plan

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Program plans are given for an integrating controller for space station autonomy as well as for controls and displays. The technical approach, facility requirements and candidate facilities, development schedules, and resource requirements estimates are given.

  2. ICESat (GLAS) Science Processing Software Document Series. Volume 2; Science Data Management Plan; 4.0

    NASA Technical Reports Server (NTRS)

    Jester, Peggy L.; Hancock, David W., III

    1999-01-01

    This document provides the Data Management Plan for the GLAS Standard Data Software (SDS) supporting the GLAS instrument of the EOS ICESat Spacecraft. The SDS encompasses the ICESat Science Investigator-led Processing System (I-SIPS) Software and the Instrument Support Facility (ISF) Software. This Plan addresses the identification, authority, and description of the interface nodes associated with the GLAS Standard Data Products and the GLAS Ancillary Data.

  3. Dosimetric advantages of generalised equivalent uniform dose-based optimisation on dose-volume objectives in intensity-modulated radiotherapy planning for bilateral breast cancer.

    PubMed

    Lee, T-F; Ting, H-M; Chao, P-J; Wang, H-Y; Shieh, C-S; Horng, M-F; Wu, J-M; Yeh, S-A; Cho, M-Y; Huang, E-Y; Huang, Y-J; Chen, H-C; Fang, F-M

    2012-11-01

    We compared and evaluated the differences between two models for treating bilateral breast cancer (BBC): (i) dose-volume-based intensity-modulated radiation treatment (DV plan), and (ii) dose-volume-based intensity-modulated radiotherapy with generalised equivalent uniform dose-based optimisation (DV-gEUD plan). The quality and performance of the DV plan and DV-gEUD plan using the Pinnacle(3) system (Philips, Fitchburg, WI) were evaluated and compared in 10 patients with stage T2-T4 BBC. The plans were delivered on a Varian 21EX linear accelerator (Varian Medical Systems, Milpitas, CA) equipped with a Millennium 120 leaf multileaf collimator (Varian Medical Systems). The parameters analysed included the conformity index, homogeneity index, tumour control probability of the planning target volume (PTV), the volumes V(20 Gy) and V(30 Gy) of the organs at risk (OAR, including the heart and lungs), mean dose and the normal tissue complication probability. Both plans met the requirements for the coverage of PTV with similar conformity and homogeneity indices. However, the DV-gEUD plan had the advantage of dose sparing for OAR: the mean doses of the heart and lungs, lung V(20) (Gy), and heart V(30) (Gy) in the DV-gEUD plan were lower than those in the DV plan (p<0.05). A better result can be obtained by starting with a DV-generated plan and then improving it by adding gEUD-based improvements to reduce the number of iterations and to improve the optimum dose distribution. Advances to knowledge The DV-gEUD plan provided superior dosimetric results for treating BBC in terms of PTV coverage and OAR sparing than the DV plan, without sacrificing the homogeneity of dose distribution in the PTV.

  4. Rectal planning risk volume correlation with acute and late toxicity in 3-dimensional conformal radiation therapy for prostate cancer.

    PubMed

    Dias, R S; Giordani, A J; Souhami, L; Segreto, R A; Segreto, H R C

    2011-12-01

    The purpose of this study was to evaluate rectum motion during 3-Dimensional conformal radiation therapy (3D-CRT) in prostate cancer patients, to derive a planning volume at risk (PRV) and to correlate the PRV dose-volume histograms (DVH) with treatment complications.This study was conducted in two phases. Initially, the PRV was defined prospectively in 50 consecutive prostate cancer patients (Group 1) who received a radical course of 3-D CRT. Then, the obtained PRV was used in the radiotherapy planning of these same 50 patients plus another 59 prostate cancer patients (Group 2) previously treated between 2004 and 2008. All these patients' data, including the rectum and PRV DVHs, were correlated to acute and late complications, according to the Common Toxicity Criteria (CTC) v4.0.The largest displacement occurred in the anterior axis. Long-term gastrointestinal (GI) complications grade ≥ 2 were seen in 9.2% of the cases. Factors that influenced acute GI reactions were: doses at 25% (p 5 0.011) and 40% (p 5 0.005) of the rectum volume and at 40% of the PRV (p 5 0.012). The dose at 25% of the rectum volume (p 5 0.033) and acute complications ≥ grade 2 (p 5 0.018) were prognostic factors for long-term complications. The PRV DVH did not correlate with late toxicity. The rectum showed a significant inter-fraction motion during 3D-CRT for prostate cancer. PRV dose correlated with acute gastrointestinal complications and may be a useful tool to predict and reduce their occurrence.

  5. ICPP calcined solids storage facility closure study. Volume II: Cost estimates, planning schedules, yearly cost flowcharts, and life-cycle cost estimates

    SciTech Connect

    1998-02-01

    This document contains Volume II of the Closure Study for the Idaho Chemical Processing Plant Calcined Solids Storage Facility. This volume contains draft information on cost estimates, planning schedules, yearly cost flowcharts, and life-cycle costs for the four options described in Volume I: (1) Risk-Based Clean Closure; NRC Class C fill, (2) Risk-Based Clean Closure; Clean fill, (3) Closure to landfill Standards; NRC Class C fill, and (4) Closure to Landfill Standards; Clean fill.

  6. Volumetric-modulated arc therapy for the treatment of a large planning target volume in thoracic esophageal cancer.

    PubMed

    Abbas, Ahmar S; Moseley, Douglas; Kassam, Zahra; Kim, Sun Mo; Cho, Charles

    2013-05-06

    Recently, volumetric-modulated arc therapy (VMAT) has demonstrated the ability to deliver radiation dose precisely and accurately with a shorter delivery time compared to conventional intensity-modulated fixed-field treatment (IMRT). We applied the hypothesis of VMAT technique for the treatment of thoracic esophageal carcinoma to determine superior or equivalent conformal dose coverage for a large thoracic esophageal planning target volume (PTV) with superior or equivalent sparing of organs-at-risk (OARs) doses, and reduce delivery time and monitor units (MUs), in comparison with conventional fixed-field IMRT plans. We also analyzed and compared some other important metrics of treatment planning and treatment delivery for both IMRT and VMAT techniques. These metrics include: 1) the integral dose and the volume receiving intermediate dose levels between IMRT and VMATI plans; 2) the use of 4D CT to determine the internal motion margin; and 3) evaluating the dosimetry of every plan through patient-specific QA. These factors may impact the overall treatment plan quality and outcomes from the individual planning technique used. In this study, we also examined the significance of using two arcs vs. a single-arc VMAT technique for PTV coverage, OARs doses, monitor units and delivery time. Thirteen patients, stage T2-T3 N0-N1 (TNM AJCC 7th edn.), PTV volume median 395 cc (range 281-601 cc), median age 69 years (range 53 to 85), were treated from July 2010 to June 2011 with a four-field (n = 4) or five-field (n = 9) step-and-shoot IMRT technique using a 6 MV beam to a prescribed dose of 50 Gy in 20 to 25 F. These patients were retrospectively replanned using single arc (VMATI, 91 control points) and two arcs (VMATII, 182 control points). All treatment plans of the 13 study cases were evaluated using various dose-volume metrics. These included PTV D99, PTV D95, PTV V9547.5Gy(95%), PTV mean dose, Dmax, PTV dose conformity (Van't Riet conformation number (CN)), mean lung dose

  7. Eleventh annual Department of Energy low-level waste management conference. Volume 2: Low-level waste strategy and planning, decontamination and decommissioning, compliance monitoring

    SciTech Connect

    1989-11-01

    Nineteen papers are presented in volume 2. The 11 papers in the LLW Strategy and Planning section discuss plans for disposal facilities in Texas, Pennsylvania, Hanford, the Southwest and Southeast Compacts, and others. Three papers discuss decontamination technology and activities. Environmental monitoring requirements and recommendations at LLW facilities are discussed in 5 papers. Papers have been processed separately for inclusion on the data base.

  8. Calculation of Lung Cancer Volume of Target Based on Thorax Computed Tomography Images using Active Contour Segmentation Method for Treatment Planning System

    NASA Astrophysics Data System (ADS)

    Patra Yosandha, Fiet; Adi, Kusworo; Edi Widodo, Catur

    2017-06-01

    In this research, calculation process of the lung cancer volume of target based on computed tomography (CT) thorax images was done. Volume of the target calculation was done in purpose to treatment planning system in radiotherapy. The calculation of the target volume consists of gross tumor volume (GTV), clinical target volume (CTV), planning target volume (PTV) and organs at risk (OAR). The calculation of the target volume was done by adding the target area on each slices and then multiply the result with the slice thickness. Calculations of area using of digital image processing techniques with active contour segmentation method. This segmentation for contouring to obtain the target volume. The calculation of volume produced on each of the targets is 577.2 cm3 for GTV, 769.9 cm3 for CTV, 877.8 cm3 for PTV, 618.7 cm3 for OAR 1, 1,162 cm3 for OAR 2 right, and 1,597 cm3 for OAR 2 left. These values indicate that the image processing techniques developed can be implemented to calculate the lung cancer target volume based on CT thorax images. This research expected to help doctors and medical physicists in determining and contouring the target volume quickly and precisely.

  9. Monitored retrievable storage submission to Congress: Volume 3, Monitored retrievable storage program plan. [Contains glossary

    SciTech Connect

    1987-03-01

    This document presents the current DOE program objectives and the strategy for implementing the proposed program for the integral MRS facility. If the MRS proposal is approved by Congress, any needed revisions to the Program Plan will be made available to the Congress, the State of Tennessee, affected Indian tribes, local governments, other federal agencies, and the public. The proposal for constructing an MRS facility must include: the establishment of a federal program for the siting, development, construction, and operation of MRS facilities; a plan for funding the construction and operation of MRS facilities; site-specific designs, specifications, and cost estimates for the first such facility; a plan for integrating MRS facilities with other storage and disposal facilities authorized by the NWPA. 32 refs., 14 figs., 1 tab.

  10. Site characterization plan: Yucca Mountain Site, Nevada Research and Development Area, Nevada: Volume 9, Index

    SciTech Connect

    1988-12-01

    This site characterization plan (SCP) has been developed for the candidate repository site at Yucca Mountain in the State of Nevada. The SCP includes a description of the Yucca Mountain site (Chapters 1-5), a conceptual design for the repository (Chapter 6), a description of the packaging to be used for the waste to be emplaced in the repository (Chapter 7), and a description of the planned site characterization activities (Chapter 8). The schedules and milestones presented in Sections 8.3 and 8.5 of the SCP were developed to be consistent with the June 1988 draft Amendment to the DOE`s Mission Plan for the Civilian Radioactive Waste Management Program. The five month delay in the scheduled start of exploratory shaft construction that was announced recently is not reflected in these schedules.

  11. Breckinridge Project, initial effort. Report VII, Volume 4. Safety and health plan

    SciTech Connect

    1982-01-01

    The Safety and Health Plan recognizes the potential hazards associated with the Project and has been developed specifically to respond to these risks in a positive manner. Prevention, the primary objective of the Plan, starts with building safety controls into the process design and continues through engineering, construction, start-up, and operation of the Project facilities and equipment. Compliance with applicable federal, state, and local health and safety laws, regulations, and codes throughout all Project phases is required and assured. The Plan requires that each major Project phase be thoroughly reviewed and analyzed to determine that those provisions required to assure the safety and health of all employees and the public, and to prevent property and equipment losses, have been provided. The Plan requires followup on those items or situations where corrective action needs were identified to assure that the action was taken and is effective. Emphasis is placed on loss prevention. Exhibit 1 provides a breakdown of Ashland Synthetic Fuels, Inc.'s (ASFI's) Loss Prevention Program. The Plan recognizes that the varied nature of the work is such as to require the services of skilled, trained, and responsible personnel who are aware of the hazards and know that the work can be done safely, if done correctly. Good operating practice is likewise safe operating practice. Training is provided to familiarize personnel with good operational practice, the general sequence of activities, reporting requirements, and above all, the concept that each step in the operating procedures must be successfully concluded before the following step can be safely initiated. The Plan provides for periodic review and evaluation of all safety and loss prevention activities at the plant and departmental levels.

  12. Mi Carrera. Volume IV: Effective Career Planning with Hispanic High School Students.

    ERIC Educational Resources Information Center

    Douglas, Denise, Ed.

    This curriculum guide, the fourth of a four-volume set that is intended to improve career and vocational guidance services to Spanish-speaking students in grades 9 through 12, is actually a collection of three different resources. The first section, "Group Activities: Intercambios," by Maria Garcia, is a model culturally based group counseling…

  13. Fiscal years 1994--1998 Information Technology Strategic Plan. Volume 1

    SciTech Connect

    Not Available

    1993-11-01

    A team of senior managers from across the US Nuclear Regulatory Commission (NRC), working with the Office of Information Resources Management (IRM), has completed an NRC Strategic Information Technology (IT) Plan. The Plan addresses three major areas: (1) IT Program Management, (2) IT Infrastructure, and (3) Information and Applications Management. Key recommendations call for accelerating the replacement of Agency workstations, implementing a new document management system, applying business process reengineering to selected Agency work processes, and establishing an Information Technology Council to advise the Director of IRM.

  14. Space Station Furnace Facility Preliminary Project Implementation Plan (PIP). Volume 2, Appendix 2

    NASA Technical Reports Server (NTRS)

    Perkey, John K.

    1992-01-01

    The Space Station Furnace Facility (SSFF) is an advanced facility for materials research in the microgravity environment of the Space Station Freedom and will consist of Core equipment and various sets of Furnace Module (FM) equipment in a three-rack configuration. This Project Implementation Plan (PIP) document was developed to satisfy the requirements of Data Requirement Number 4 for the SSFF study (Phase B). This PIP shall address the planning of the activities required to perform the detailed design and development of the SSFF for the Phase C/D portion of this contract.

  15. IUS/TUG orbital operations and mission support study. Volume 4: Project planning data

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Planning data are presented for the development phases of interim upper stage (IUS) and tug systems. Major project planning requirements, major event schedules, milestones, system development and operations process networks, and relevant support research and technology requirements are included. Topics discussed include: IUS flight software; tug flight software; IUS/tug ground control center facilities, personnel, data systems, software, and equipment; IUS mission events; tug mission events; tug/spacecraft rendezvous and docking; tug/orbiter operations interface, and IUS/orbiter operations interface.

  16. Automated En Route Air Traffic Control Algorithmic Specifications. Volume 3. Flight Plan Conflict Probe,

    DTIC Science & Technology

    1983-09-01

    effective time for cells in hold maneuver M Loop index N Loop index XEnd Final x coordinate for line covering hold X Beg Starting x coordinate for line...construct means exactly what "Table name"." field name" would have meant if the loop had not bees in effect . The GO TO Construct 9 The syntax of the GO TO...2 1.4 Role of Flight Plan Conflict Probe in the Overall ATC System 1-3 1.4.1 System Context 1-3 1.4.2 Effect of Future MAS Enhancements on Flight Plan

  17. Determination of Internal Target Volume for Radiation Treatment Planning of Esophageal Cancer by Using 4-Dimensional Computed Tomography (4DCT)

    SciTech Connect

    Chen, Xiaojian; Lu, Haijun; Tai, An; Johnstone, Candice; Gore, Elizabeth; Li, X. Allen

    2014-09-01

    Purpose: To determine an efficient strategy for the generation of the internal target volume (ITV) for radiation treatment planning for esophageal cancer using 4-dimensional computed tomography (4DCT). Methods and Materials: 4DCT sets acquired for 20 patients with esophageal carcinoma were analyzed. Each of the 4DCT sets was binned into 10 respiratory phases. For each patient, the gross tumor volume (GTV) was delineated on the 4DCT set at each phase. Various strategies to derive ITV were explored, including the volume from the maximum intensity projection (MIP; ITV{sub M}IP), unions of the GTVs from selected multiple phases ITV2 (0% and 50% phases), ITV3 (ITV2 plus 80%), and ITV4 (ITV3 plus 60%), as well as the volumes expanded from ITV2 and ITV3 with a uniform margin. These ITVs were compared to ITV10 (the union of the GTVs for all 10 phases) and the differences were measured with the overlap ratio (OR) and relative volume ratio (RVR) relative to ITV10 (ITVx/ITV10). Results: For all patients studied, the average GTV from a single phase was 84.9% of ITV10. The average ORs were 91.2%, 91.3%, 94.5%, and 96.4% for ITV{sub M}IP, ITV2, ITV3, and ITV4, respectively. Low ORs were associated with irregular breathing patterns. ITV3s plus 1 mm uniform margins (ITV3+1) led to an average OR of 98.1% and an average RVR of 106.4%. Conclusions: The ITV generated directly from MIP underestimates the range of the respiration motion for esophageal cancer. The ITV generated from 3 phases (ITV3) may be used for regular breathers, whereas the ITV generated from 4 phases (ITV4) or ITV3 plus a 1-mm uniform margin may be applied for irregular breathers.

  18. Fully Automatic Guidance and Control for Rotorcraft Nap-of-the-earth Flight Following Planned Profiles. Volume 2: Mathematical Model

    NASA Technical Reports Server (NTRS)

    Clement, Warren F.; Gorder, Peter J.; Jewell, Wayne F.

    1991-01-01

    Developing a single-pilot, all-weather nap-of-the-earth (NOE) capability requires fully automatic NOE (ANOE) navigation and flight control. Innovative guidance and control concepts are investigated in a four-fold research effort that: (1) organizes the on-board computer-based storage and real-time updating of NOE terrain profiles and obstacles in course-oriented coordinates indexed to the mission flight plan; (2) defines a class of automatic anticipative pursuit guidance algorithms and necessary data preview requirements to follow the vertical, lateral, and longitudinal guidance commands dictated by the updated flight profiles; (3) automates a decision-making process for unexpected obstacle avoidance; and (4) provides several rapid response maneuvers. Acquired knowledge from the sensed environment is correlated with the forehand knowledge of the recorded environment (terrain, cultural features, threats, and targets), which is then used to determine an appropriate evasive maneuver if a nonconformity of the sensed and recorded environments is observed. This four-fold research effort was evaluated in both fixed-base and moving-base real-time piloted simulations; thereby, providing a practical demonstration for evaluating pilot acceptance of the automated concepts, supervisory override, manual operation, and re-engagement of the automatic system. Volume one describes the major components of the guidance and control laws as well as the results of the piloted simulations. Volume two describes the complete mathematical model of the fully automatic guidance system for rotorcraft NOE flight following planned flight profiles.

  19. The optimization of intensity modulated radiotherapy in cases where the planning target volume extends into the build-up region.

    PubMed

    Nguyen, T B; Hoole, A C F; Burnet, N G; Thomas, S J

    2009-04-21

    A common clinical problem in IMRT, especially when treating head and neck cases, is that the clinical target volume (CTV) stops short of the skin surface, whilst the margin for geometric uncertainties may take the planning target volume (PTV) to the skin surface or beyond. In these cases, optimization leads to over-dosing of the skin, unless the planner resorts to procedural tricks to avoid this, such as the use of pretend bolus or reduction of the PTV followed by adding 'flash' after optimization. This paper describes a method of avoiding the need for these tricks by using a multiple-isocentre CTV-based objective function. This enables plans to be produced that will give good coverage of the CTV for all the geometrical uncertainties that would have been covered by the PTV without causing the problem of over-dosing the skin. Eight isocentre shifts, equally distributed on the surface of a sphere with a radius equal to the CTV-PTV margin, are shown to be adequate for the optimization process. The resulting fluence maps are much simpler than those resulting from PTV optimization and will therefore be simpler to deliver. The method also permits better sparing of organs at risk such as the spinal cord.

  20. The optimization of intensity modulated radiotherapy in cases where the planning target volume extends into the build-up region

    NASA Astrophysics Data System (ADS)

    Nguyen, T. B.; Hoole, A. C. F.; Burnet, N. G.; Thomas, S. J.

    2009-04-01

    A common clinical problem in IMRT, especially when treating head and neck cases, is that the clinical target volume (CTV) stops short of the skin surface, whilst the margin for geometric uncertainties may take the planning target volume (PTV) to the skin surface or beyond. In these cases, optimization leads to over-dosing of the skin, unless the planner resorts to procedural tricks to avoid this, such as the use of pretend bolus or reduction of the PTV followed by adding 'flash' after optimization. This paper describes a method of avoiding the need for these tricks by using a multiple-isocentre CTV-based objective function. This enables plans to be produced that will give good coverage of the CTV for all the geometrical uncertainties that would have been covered by the PTV without causing the problem of over-dosing the skin. Eight isocentre shifts, equally distributed on the surface of a sphere with a radius equal to the CTV-PTV margin, are shown to be adequate for the optimization process. The resulting fluence maps are much simpler than those resulting from PTV optimization and will therefore be simpler to deliver. The method also permits better sparing of organs at risk such as the spinal cord.

  1. Studies in Family Planning, Volume 5 Number 5. East Asia Review, 1973.

    ERIC Educational Resources Information Center

    Keeny, S. M., Ed.

    An annual review, third in a series, covers developments in the field of population and family planning in East Asia. For each of the 10 countries involved (Hong Kong, Indonesia, South Korea, Laos, Malaysia, Phillipines, Singapore, Taiwan, Thailand, and South Vietnam) there is an article written by the agent responsible for the family planning…

  2. Scheduling Algorithm for Mission Planning and Logistics Evaluation (SAMPLE). Volume 2: Mission payloads subsystem description

    NASA Technical Reports Server (NTRS)

    Dupnick, E.; Wiggins, D.

    1980-01-01

    The scheduling algorithm for mission planning and logistics evaluation (SAMPLE) is presented. Two major subsystems are included: The mission payloads program; and the set covering program. Formats and parameter definitions for the payload data set (payload model), feasible combination file, and traffic model are documented.

  3. Enrollment Forecasting Procedures. A Vocational Education Planning System for Local School Districts. Volume V.

    ERIC Educational Resources Information Center

    Post, Arnold R.

    The document, one in a series to assist in planning procedures for local and State vocational agencies, describes two computer programs, COMENR and VOCEDENR, to be used in secondary enrollment forecasts. The steps in the procedure are: 1) gather data on past public enrollment, new housing trends, census data, and current vocational enrollments and…

  4. Community College Journal for Research and Planning, Volume 3, Number 1.

    ERIC Educational Resources Information Center

    Carter, Edith H., Ed.

    1983-01-01

    Designed as a forum for the exchange of ideas among research and planning professionals, this journal presents articles and reviews books on topics of concern to community colleges. First, E. Timothy Lightfield examines 10 socioeconomic trends and offers suggestions to enable colleges to thrive in the face of these changes in his essay,…

  5. Education as Experimentation: A Planned Variation Model. Volume IV-A: An Evaluation of Follow Through.

    ERIC Educational Resources Information Center

    Stebbins, Linda B.; And Others

    This segment of the national evaluation study of the Follow Through Planned Variation Model presents background information and discusses the evaluation of the progress of Cohort III entering-kindergarten children during 4 years of Follow Through participation. Also discussed, for the purpose of examining replicability of effects, is the progress…

  6. STUDENT'S PERSONAL ADJUSTMENT TO WORK, SUGGESTED PLANS FOR GROUP DISCUSSIONS IN VOCATIONAL INDUSTRIAL EDUCATION. VOLUME II.

    ERIC Educational Resources Information Center

    Texas Education Agency, Austin. Industrial Education Div.

    VOCATIONAL TEACHERS CAN USE THIS STUDY GUIDE AS AN ORGANIZED PLAN OF DEVELOPING APPROPRIATE DISCUSSION TOPICS RELATIVE TO JOB ORIENTATION IN 2-YEAR PART-TIME CLASSES. IT WAS DEVELOPED BY AN INSTRUCTOR-COORDINATOR AND AN ADVISORY COMMITTEE. MAJOR DIVISIONS ARE (1) PERSONAL TRAITS, (2) MONEY AND BANKING, (3) SCHOOL RELATIONS, (4) CIVIC…

  7. Integrated payload and mission planning, phase 3. Volume 3: Ground real-time mission operations

    NASA Technical Reports Server (NTRS)

    White, W. J.

    1977-01-01

    The payloads tentatively planned to fly on the first two Spacelab missions were analyzed to examine the cost relationships of providing mission operations support from onboard vs the ground-based Payload Operations Control Center (POCC). The quantitative results indicate that use of a POCC, with data processing capability, to support real-time mission operations is the most cost effective case.

  8. Refugee Camp Planning And Construction Handbook - Air Force Handbook 10-222, Volume 22

    DTIC Science & Technology

    2000-06-15

    not display a currently valid OMB control number. 1. REPORT DATE 15 JUN 2000 2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE...General Planning Considerations 4 Organizations, Command and Control , and Authority 7 Coordination with Other Interested Parties...Construction Base Camp Siting and Layout 56 Logistics 65 Procurement and Property Control 65

  9. Community College Journal for Research and Planning, Volume 3, Number 1.

    ERIC Educational Resources Information Center

    Carter, Edith H., Ed.

    1983-01-01

    Designed as a forum for the exchange of ideas among research and planning professionals, this journal presents articles and reviews books on topics of concern to community colleges. First, E. Timothy Lightfield examines 10 socioeconomic trends and offers suggestions to enable colleges to thrive in the face of these changes in his essay,…

  10. Job Demand Forecasting Program. A Vocational Education Planning System for Local School Districts. Volume VII.

    ERIC Educational Resources Information Center

    Maxim, D.; And Others

    The report, one of a series resulting from a project to design planning procedures for local and State vocational agencies, describes LIONS (Labor and Industry Occupational Needs System), a computer system designed to provide forecasts of the demand for various occupational skills by area for the State of New Jersey. The methodology may have…

  11. SSTAC/ARTS review of the draft Integrated Technology Plan (ITP). Volume 5: Human Support

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Viewgraphs of briefings from the Space Systems and Technology Advisory Committee (SSTAC)/ARTS review of the draft integrated technology plan (ITP) on human support are included. Topics covered include: human support program; human factors; life support technology; fire safety; medical support technology; advanced refrigeration technology; EVA suit system; advanced PLSS technology; and ARC-EVA systems research program.

  12. Securing Our Future: Planning What We Want for Our Youngest Children. Future Trends Report, Volume VI.

    ERIC Educational Resources Information Center

    Barton, Alice

    This report is the sixth on future trends in early care and education undertaken by the Massachusetts Early Childhood Advisory Council since its inception in 1985. The report sets out a plan for a system of early care and education and family support in the state, fulfilling a requirement of the enabling legislation of the Community Partnerships…

  13. Structures for Science: A Handbook for Planning Facilities for Undergraduate Natural Science Communities, Volume Three.

    ERIC Educational Resources Information Center

    Narum, Jeanne L., Ed.

    The goal of this handbook is to enable those who plan structures for undergraduate science communities to see the process as evolutionary and organic, a process integrally related to ongoing efforts to provide a quality learning experience for the students on the campus. The handbook presents many of the questions that need to be addressed as…

  14. The Stamford Public Education Facilities Utilization Plan. Stamford Educational Public Policy Impact Study. Volume IV.

    ERIC Educational Resources Information Center

    Feld, Marcia Marker; And Others

    In the last decade, Stamford has been transformed from a suburban town to an urban center of national renown. A responsive yet directive public school system is critical in preserving a feeling of community. The Stanford Educational Planning Committee, a team of interdisciplinary professionals and a broad-based community group, examined trends in…

  15. An Inventory of Documents on Educational Planning and Management in Asia and the Pacific, Volume 2.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Bangkok (Thailand). Regional Office for Education in Asia and the Pacific.

    This inventory of documents on educational planning and management includes from 20 UNESCO (United Nations Educational Scientific and Cultural Organization) member countries in Asia and the Pacific. A new section in this edition, the Asia and Pacific region, includes citations that address trends and conceptual issues affecting member states of…

  16. Issues of Language Assessment. Volume II: Language Assessment and Curriculum Planning.

    ERIC Educational Resources Information Center

    Seidner, Stanley S., Ed.

    These 25 papers address issues of second language assessment and curriculum planning. The papers are divided into three categories: theoretical foundations, assessment approaches, and research and policy. Among the specific topics discussed are: whether tests measure language or intelligence, additive versus subtractive bilingualism, the…

  17. Proposed site treatment plan (PSTP) Volumes I & II & reference document, Revision 3

    SciTech Connect

    Helmich, E.; Noller, D.K.; Wierzbicki, K.S.

    1995-09-27

    The Federal Facility Compliance Act requires the Department of Energy to undertake a national effort to develop Site Treatment Plans for each of its sites generating or storing mixed waste. Mixed waste contains both a hazardous waste subject to the Resource Conservation and Recovery Act and radioactive material subject to the Atomic Energy Act of 1954. The Site Treatment Plan for the Savannah River Site proposes how SRS will treat mixed waste that is now stored on the site and mixed waste that Will be generated in the future. Also, the Site Treatment Plan identifies Savannah River Site mixed wastes that other Department of Energy facilities could treat and mixed waste from other facilities that the Savannah River Site could treat. The Site Treatment Plan has been approved by the State of South Carolina. The Department of Energy Will enter into a consent order with the State of South Carolina by October 6, 1995. The consent order will contain enforceable commitments to treat mixed waste.

  18. Study of solid rocket motors for a space shuttle booster. Volume 3: Program acquisition planning

    NASA Technical Reports Server (NTRS)

    Vonderesch, A. H.

    1972-01-01

    Plans for conducting Phase C/D for a solid rocket motor booster vehicle are presented. Methods for conducting this program with details of scheduling, testing, and program management and control are included. The requirements of the space shuttle program to deliver a minimum cost/maximum reliability booster vehicle are examined.

  19. DDC 10 Year Requirements and Planning Study. Volume II. Technical Discussion, Bibliography, and Glossary

    DTIC Science & Technology

    1976-06-12

    Technology of Information Procesoing (1978-1988) ........ .................. ... 39 2.2.3 Organizational Interface Between DDC and Other Information...Requirements and Planning Study: Expert Penal Review Report. December 31, 1975. (AUER-2325/2326-T-N5 AD-A022 303) TABLE 14 Evaluation of Technological

  20. Greater Postimplant Swelling in Small-Volume Prostate Glands: Implications for Dosimetry, Treatment Planning, and Operating Room Technique

    SciTech Connect

    Chung, Eugene; Stenmark, Matthew H.; Evans, Cheryl; Narayana, Vrinda; McLaughlin, Patrick W.

    2012-04-01

    Purpose: Postimplant prostatic edema has been implicated in suboptimal permanent implants, and smaller prostates have been reported to have worse dosimetric coverage. In this study we compare the degree of postimplant edema between larger and smaller prostates and examine the effects of prostate size on the dose delivered to 90% of the prostate (D90). Methods and Materials: From September 2003 to February 2006, 105 hormone-naive patients underwent permanent prostate brachytherapy with {sup 125}I Rapid Strand (Oncura Inc., Arlington Heights, IL). All patients underwent pelvic magnetic resonance imaging (MRI) within 3 weeks before implant, transrectal ultrasound at the time of implant, and both computed tomography and MRI 2.5 to 3 weeks after implant. Prostates were divided into 5 subgroups based on preimplant MRI volumes: less than 25 mL, 25 to 35 mL, 35 to 45 mL, 45 to 55 mL, and greater than 55 mL. Prostate swelling was assessed by use of preimplant and postimplant MRI volumes. Postimplant dosimetry was determined by MRI and compared between the subgroups. Results: All prostates showed postimplant swelling on MRI when compared with preimplant MRI, with a mean increase of 31% {+-} 31% (p < 0.0001). The greatest swelling was noted in small prostates (volume less than 25 mL), with a mean increase of 70% {+-} 36%. The degree of swelling in the group with a volume less than 25 mL was significantly larger than the degree of swelling in all other prostate subgroups (p < 0.003). Transrectal ultrasound significantly overestimates the prostate volume when compared with MRI by a mean of 15% {+-} 25% (p = 0.0006) and is more pronounced for smaller prostates. Although prostates with volumes less than 25 mL did not have significantly worse D90 compared with larger prostates, they had the largest percent of suboptimal implants by the standard ratio of D90 divided by the prescription dose. Conclusions: Although small prostates have the greatest postimplant edema, planning

  1. Addition of magnetic resonance imaging to computed tomography-based three-dimensional conformal radiotherapy planning for postoperative treatment of astrocytomas: Changes in tumor volume and isocenter shift.

    PubMed

    Bagri, Puneet Kumar; Kapoor, Akhil; Singh, Daleep; Singhal, Mukesh Kumar; Narayan, Satya; Kumar, Harvindra Singh

    2015-01-01

    Postoperative radiotherapy is the current gold standard treatment in astrocytomas. Computed tomography (CT)-based radiotherapy planning leads to either missing of the tumor volume or underdosing. The aim of this prospective study was to study the changes in tumor volume on addition of magnetic resonance imaging (MRI) to CT-based three-dimensional radiotherapy treatment planning of astrocytomas. Twenty-five consecutive patients of astrocytoma (WHO grades I-IV) for postoperative three-dimensional conformal radiotherapy were included in this prospective study. Postoperative tumor volumes were contoured on CT-based images and recontoured on CT-MRI images after automated MRI co-registration on treatment planning system Eclipse 8.9.15 as per ICRU-50 report. Tumor volumes were compared with each other. The MRI-based mean and median tumor volume was 24.24 cc ± 13.489 and 18.72 cc (range 5.6-46.48 cc), respectively, while for CT it was 19.4 cc ± 11.218 and 16.24 cc (range: 5.1-38.72 cc), respectively. The mean and median isocenter shift between CT and MRI was 4.05 mm and 4.39 mm (range 0.92-6.32 mm), respectively. There is a linear relationship between MRI and CT volume with a good correlation coefficient of R (2) = 0.989, and MRI-based tumor volume was 1.208 times as compared to CT volume. Statistical analysis using paired sample t-test for the difference in CT and MRI tumor volume was highly significant (P < 0.001). Addition of MRI to the CT-based three-dimensional radiation treatment planning reduces the chances of geographical miss or tumor under dosing. Thus, MRI should be an integral part of three-dimensional planning of astrocytomas.

  2. Addition of magnetic resonance imaging to computed tomography-based three-dimensional conformal radiotherapy planning for postoperative treatment of astrocytomas: Changes in tumor volume and isocenter shift

    PubMed Central

    Bagri, Puneet Kumar; Kapoor, Akhil; Singh, Daleep; Singhal, Mukesh Kumar; Narayan, Satya; Kumar, Harvindra Singh

    2015-01-01

    Introduction: Postoperative radiotherapy is the current gold standard treatment in astrocytomas. Computed tomography (CT)-based radiotherapy planning leads to either missing of the tumor volume or underdosing. The aim of this prospective study was to study the changes in tumor volume on addition of magnetic resonance imaging (MRI) to CT-based three-dimensional radiotherapy treatment planning of astrocytomas. Materials and Methods: Twenty-five consecutive patients of astrocytoma (WHO grades I-IV) for postoperative three-dimensional conformal radiotherapy were included in this prospective study. Postoperative tumor volumes were contoured on CT-based images and recontoured on CT-MRI images after automated MRI co-registration on treatment planning system Eclipse 8.9.15 as per ICRU-50 report. Tumor volumes were compared with each other. Result: The MRI-based mean and median tumor volume was 24.24 cc ± 13.489 and 18.72 cc (range 5.6–46.48 cc), respectively, while for CT it was 19.4 cc ± 11.218 and 16.24 cc (range: 5.1-38.72 cc), respectively. The mean and median isocenter shift between CT and MRI was 4.05 mm and 4.39 mm (range 0.92–6.32 mm), respectively. There is a linear relationship between MRI and CT volume with a good correlation coefficient of R2 = 0.989, and MRI-based tumor volume was 1.208 times as compared to CT volume. Statistical analysis using paired sample t-test for the difference in CT and MRI tumor volume was highly significant (P < 0.001). Conclusion: Addition of MRI to the CT-based three-dimensional radiation treatment planning reduces the chances of geographical miss or tumor under dosing. Thus, MRI should be an integral part of three-dimensional planning of astrocytomas. PMID:25839014

  3. Dosimetric evaluation of planning target volume margin reduction for prostate cancer via image-guided intensity-modulated radiation therapy

    NASA Astrophysics Data System (ADS)

    Hwang, Taejin; Kang, Sei-Kwon; Cheong, Kwang-Ho; Park, Soah; Yoon, Jai-Woong; Han, Taejin; Kim, Haeyoung; Lee, Meyeon; Kim, Kyoung-Joo; Bae, Hoonsik; Suh, Tae-Suk

    2015-07-01

    The aim of this study was to quantitatively estimate the dosimetric benefits of the image-guided radiation therapy (IGRT) system for the prostate intensity-modulated radiation therapy (IMRT) delivery. The cases of eleven patients who underwent IMRT for prostate cancer without a prostatectomy at our institution between October 2012 and April 2014 were retrospectively analyzed. For every patient, clinical target volume (CTV) to planning target volume (PTV) margins were uniformly used: 3 mm, 5 mm, 7 mm, 10 mm, 12 mm, and 15 mm. For each margin size, the IMRT plans were independently optimized by one medical physicist using Pinnalce3 (ver. 8.0.d, Philips Medical System, Madison, WI) in order to maintain the plan quality. The maximum geometrical margin (MGM) for every CT image set, defined as the smallest margin encompassing the rectum at least at one slice, was between 13 mm and 26 mm. The percentage rectum overlapping PTV (%V ROV ), the rectal normal tissue complication probability (NTCP) and the mean rectal dose (%RD mean ) increased in proportion to the increase of PTV margin. However the bladder NTCP remained around zero to some extent regardless of the increase of PTV margin while the percentage bladder overlapping PTV (%V BOV ) and the mean bladder dose (%BD mean ) increased in proportion to the increase of PTV margin. Without relatively large rectum or small bladder, the increase observed for rectal NTCP, %RDmean and %BD mean per 1-mm PTV margin size were 1.84%, 2.44% and 2.90%, respectively. Unlike the behavior of the rectum or the bladder, the maximum dose on each femoral head had little effect on PTV margin. This quantitative study of the PTV margin reduction supported that IG-IMRT has enhanced the clinical effects over prostate cancer with the reduction of normal organ complications under the similar level of PTV control.

  4. Air Disaster Response Planning: Lessons for the Future. Volume 2, Number 5

    DTIC Science & Technology

    1985-01-01

    Saint Louis University Saint Louis, Missouri DTIC ELECTEE AUG24O 990ST ED National Emergency Training Center Emmitsburg, Maryland MONOGRAPH SERIES 1985...Volume 2 Number 5 £pprwed pow %bow 8 2 : "This is another in a series of monographs on the subject of emergency manage- ment. The purposetef this series...is to share new ideas and information in the field of emergency management. The content does not necessarily represent either the policy or the

  5. A Strategic Planning Framework for Predicting and Evaluating Soviet Interests in Arms Control. Volume 1

    DTIC Science & Technology

    1988-08-01

    EVALUATING SOVIET INTERESTS IN ARMS CONTROL VOLUME I by KERRY M. KARTCHNER AUGUST 1988 Approved for public release; distribution Unlimited. Prepared...AuTH.ORiTY I DISTRIBUTION’ AVAILASIOTY OF REPORT Io DC-S,,CTON DOWNGRADING SCHEDULE Approved for public release... publications , as well as Congressional hearings and reports; 3. translated Soviet sources; and, 4. other U.S. publications , books, journal articles

  6. The effect of image-guided radiation therapy on the margin between the clinical target volume and planning target volume in lung cancer

    SciTech Connect

    Liang, Jun; Li, Minghui; Zhang, Tao; Han, Wei; Chen, Dongfu; Hui, Zhouguang; Lv, Jima; Zhang, Zhong; Zhang, Yin; Zhang, Liansheng; Zheng, Rong; Dai, Jianrong; Wang, Luhua

    2014-02-15

    Introduction: This study aimed to evaluate the effect of image-guided radiation therapy (IGRT) on the margin between the clinical target volume (CTV) and planning target volume (PTV) in lung cancer. Methods: The CTV and PTV margin were determined in three dimensions by four radiation oncologists using a standard method in 10 lung cancer patients, and compared to consensus values. Transfer error was measured using a rigid phantom containing gold markers. Systematic error and random error set up errors were calculated in three dimensions from pre-treatment and post-treatment cone beam CT scans. Finally, the margin between the CTV and PTV was corrected for set up error and calculated. Results: The margins between the CTV and PTV with IGRT (and without IGRT) were 0.88 cm (0.96 cm), 0.99 cm (1.08 cm) and 1.28 cm (1.82 cm) in the anterior and posterior (AP), left and right (LR) and superior and inferior (SI) directions, respectively. Images from two other patients verified the validity of the corrected margin. The target delineation errors of the radiation oncologists are considered to be the largest compared with the set up errors. The application of IGRT reduced the set up errors and the margins between CTV and PTV. Conclusions: The delineation errors of radiation oncologists are the most important factor to consider for the margin between CTV and PTV for lung cancer. IGRT can reduce the margins by reducing the set up errors, especially in the SI direction. Further research is required to assess whether the reduction in the margin is solely based on set up errors.

  7. Integrated payload and mission planning, phase 3. Volume 4: Optimum utilization of Spacelab racks and pallets

    NASA Technical Reports Server (NTRS)

    Logston, R. G.; Budris, G. D.

    1977-01-01

    The methodology to optimize the utilization of Spacelab racks and pallets and to apply this methodology to the early STS Spacelab missions was developed. A review was made of Spacelab Program requirements and flow plans, generic flow plans for racks and pallets were examined, and the principal optimization criteria and methodology were established. Interactions between schedule, inventory, and key optimization factors; schedule and cost sensitivity to optional approaches; and the development of tradeoff methodology were addressed. This methodology was then applied to early spacelab missions (1980-1982). Rack and pallet requirements and duty cycles were defined, a utilization assessment was made, and several trade studies performed involving varying degrees of Level IV integration, inventory level, and shared versus dedicated Spacelab racks and pallets.

  8. PLANS; a finite element program for nonlinear analysis of structures. Volume 2: User's manual

    NASA Technical Reports Server (NTRS)

    Pifko, A.; Armen, H., Jr.; Levy, A.; Levine, H.

    1977-01-01

    The PLANS system, rather than being one comprehensive computer program, is a collection of finite element programs used for the nonlinear analysis of structures. This collection of programs evolved and is based on the organizational philosophy in which classes of analyses are treated individually based on the physical problem class to be analyzed. Each of the independent finite element computer programs of PLANS, with an associated element library, can be individually loaded and used to solve the problem class of interest. A number of programs have been developed for material nonlinear behavior alone and for combined geometric and material nonlinear behavior. The usage, capabilities, and element libraries of the current programs include: (1) plastic analysis of built-up structures where bending and membrane effects are significant, (2) three dimensional elastic-plastic analysis, (3) plastic analysis of bodies of revolution, and (4) material and geometric nonlinear analysis of built-up structures.

  9. Ultrahigh head pump/turbine development program: Volume 8, Confirmatory testing plan: Final report

    SciTech Connect

    Yokoyama, T.

    1987-01-01

    This report concerns the studies made in Task 6, ''Confirmatory Model Testing Plan and Procedure.'' This task reviews the entire design and testing development program of the two-stage pump/turbine. Task 6 is aimed at evaluating whatever additional work is required to demonstrate and verify to the utilities the reliability and actual performance of the developed machine. Purpose of this entire program is to provide the utilities with the best available technological and practical design for a trouble free two-stage pump/turbine. The following three plans are proposed and studied to further confirm the reliability and performance of the prototype pump/turbine: construction of pilot machine; actual head test in laboratory; and component tests in shop.

  10. A solar extreme ultraviolet telescope and spectrograph for space shuttle. Volume 1: Investigation and technical plan

    NASA Technical Reports Server (NTRS)

    Neupert, W. M.

    1978-01-01

    A scientific investigation of heating and mass transport in the solar corona that is currently planned for a future Shuttle/Spacelab flight is outlined. The instrument to be used is a near-normal incidence grating spectrograph fed by a grazing incidence Wolter Type 2 telescope. A toroidal grating design provides stigmatic images of the corona up to 8 arc min in extent over the spectral region from 225 A to 370 A. Spatial resolution of at least 2 arc sec and spectral resolution of 0.050 A is achievable throughout the central 4 arc min field or view. Primary scientific data are recorded on Schumann-type film. An H-alpha slit jaw monitor and zero order extreme ultraviolet monitor are also planned to support instrument operation.

  11. Space Assembly, Maintenance and Servicing Study. Volume 4: Concept Development Plan.

    DTIC Science & Technology

    2007-11-02

    Descriptors, Keywords: SAMS System Analysis Design Test Demonstration Buoyancy Integrated Concept Development IOC Air Force CDP Candidate Application...Determined WETF Water Emersion Test Facility Vll LMSC-F104866 Vol. IV TABLE OF CONTENTS Section Page 1.0 INTRODUCTION 1-1 2.0 PROGRAM SUMMARY 2.1...plan defines the analyses, studies, technology development and ground/flight testing which will lead to a SAMS IOC. This concept development

  12. Space Station crew safety alternatives study. Volume 5: Space Station safety plan

    NASA Technical Reports Server (NTRS)

    Mead, G. H.; Peercy, R. L., Jr.; Raasch, R. F.

    1985-01-01

    The Space Station Safety Plan has been prepared as an adjunct to the subject contract final report, suggesting the tasks and implementation procedures to ensure that threats are addressed and resolution strategy options identified and incorporated into the space station program. The safety program's approach is to realize minimum risk exposure without levying undue design and operational constraints. Safety objectives and risk acceptances are discussed.

  13. The space shuttle payload planning working groups. Volume 3: High energy astrophysics

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The findings of the High Energy Astrophysics working group of the space shuttle payload planning activity are presented. The objectives to be accomplished during space shuttle missions are defined as: (1) X-ray astronomy, (2) hard X-ray and gamma ray astronomy, and (3) cosmic ray astronomy. The instruments and test equipment required to accomplish the mission are identified. Recommendations for managing the installation of the equipment and conducting the missions are included.

  14. Northeast Artificial Intelligence Consortium (NAIC). Volume 2. Discussing, Using, and Recognizing Plans

    DTIC Science & Technology

    1990-12-01

    BIBLIOGRAPHY 113 APPENDIX 2.A TOM GRAMMAR 115 2.A.1 Verbal Elements in the SNePS ATN ....................................................... 115 2.A.2...knowledge representation/reasoning (KRR) system; enhance the KRR system so that it can act according to such plans; 2. write a grammar to direct an...our implementation of the grammar , the rules in the knowledge base, and the focussing algorithm. SNePS, the knowledge representation/reasoning system

  15. Jefferson Proving Ground, South of the Firing Line, Quality Control Plan. Volume III

    DTIC Science & Technology

    1992-09-01

    CERCLA CLP CNES COC CRL DOT DQOs EPA ID JPG NCP NEPA OSHA PID QA/QC QAP QCP RI/FS SARA semi-VOCs TPH USATHAMA UTM uxo VOCs...assurance/quality control Quality Assurance Program Quality Control Plan Remedial Investigation/Feasibility Studies Superfund Amendments and...Program (QAP) requirements and the requirements of the Comprehensive Environmental Response, Compensation, and Liability Act ( CERCLA ) as amended by

  16. Asian Security Challenges-Planning the Face of Strategic Uncertainties. Volume 1. Main Report

    DTIC Science & Technology

    1994-10-01

    body of cold-war analytic and planning techniques to be unseated; methodologically, the region is tabula rasa . We found that net assessments have their...countries. The result was substantially enhanced comprehension of the roles played by the U.S. and Soviet research, deVelopment, and acquisition processes...address these challenges. Technology will no doubt have an important role in the military power of many Asian nations, although not necessarily in

  17. The space shuttle payload planning working groups. Volume 2: Atmospheric and space physics

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The findings of the Atmospheric and Space Physics working group of the space shuttle mission planning activity are presented. The principal objectives defined by the group are: (1) to investigate the detailed mechanisms which control the near-space environment of the earth, (2) to perform plasma physics investigations not feasible in ground-based laboratories, and (3) to conduct investigations which are important in understanding planetary and cometary phenomena. The core instrumentation and laboratory configurations for conducting the investigations are defined.

  18. The space shuttle payload planning working groups. Volume 6: Communications and navigation

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The findings of the Communications and Navigation working group of the space shuttle payload planning activity are presented. The basic goals to be accomplished are to increase the use of space systems and to develop new space capabilities for providing communication and navigation services to the user community in the 1980 time period. Specific experiments to be conducted for improving space communication and navigation capabilities are defined. The characteristics of the experimental equipment required to accomplish the mission are discussed.

  19. Multiple IMU system test plan, volume 4. [subroutines for space shuttle requirements

    NASA Technical Reports Server (NTRS)

    Landey, M.; Vincent, K. T., Jr.; Whittredge, R. S.

    1974-01-01

    Operating procedures for this redundant system are described. A test plan is developed with two objectives. First, performance of the hardware and software delivered is demonstrated. Second, applicability of multiple IMU systems to the space shuttle mission is shown through detailed experiments with FDI algorithms and other multiple IMU software: gyrocompassing, calibration, and navigation. Gimbal flip is examined in light of its possible detrimental effects on FDI and navigation. For Vol. 3, see N74-10296.

  20. The space shuttle payload planning working groups. Volume 10: Space technology

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The findings and recommendations of the Space Technology group of the space shuttle payload planning activity are presented. The elements of the space technology program are: (1) long duration exposure facility, (2) advanced technology laboratory, (3) physics and chemistry laboratory, (4) contamination experiments, and (5) laser information/data transmission technology. The space technology mission model is presented in tabular form. The proposed experiments to be conducted by each test facility are described. Recommended approaches for user community interfacing are included.

  1. Shuttle/Agena study. Volume 2, part 3: Preliminary test plans

    NASA Technical Reports Server (NTRS)

    1972-01-01

    Proposed testing for the Agena tug program is based upon best estimates of shuttle and Agena tug requirements and upon the Agena configuration currently envisioned to meet these requirements. The proposed tests are presented in development, qualification, system, and launch base test plans. These plans are based upon generalized requirements and assumed situations. The limitations of this study precluded all but minimal consideration of related shuttle orbiter and shuttle ground systems. The test plans include provisions for all testing from major component to systems level, identified as necessary to aid in confirmation of the modified Agena configuration for the space tug; considerations that crew safety requirements and new environmental conditions from shuttle interface effects do impose some new Agena testing requirements; considerations that many existing Agena flight-qualified components will be utilized and qualification testing will be minimal; testing not only for the Agena tug but also for new or modified items of handling or servicing equipment for supporting the Agena factory-to-launch sequence; and the assembly of required testing into a sequence-ordered series of events.

  2. Application of radar for automotive collision avoidance. Volume 2: Development plan and progress reports

    NASA Technical Reports Server (NTRS)

    Lichtenberg, Christopher L. (Editor)

    1987-01-01

    The purpose of this project was research and development of an automobile collision avoidance radar system. Items within the scope of the one-year effort were to: (1) review previous authors' work in this field; (2) select a suitable radar approach; (3) develop a system design; (4) perform basic analyses and observations pertinent to radar design, performance, and effects; (5) fabricate and collect radar data from a data collection radar; (6) analyze and derive conclusions from the radar data; and (7) make recommendations about the likelihood of success of the investigated radar techniques. The final technical report presenting all conclusions is contained in Volume 1.

  3. Armored Family of Vehicles (AFV) Automation and Communication. Resource Management Plan (ACRMP). Phase 1. Volume 15.

    DTIC Science & Technology

    1987-09-01

    BCE S 7 xi TRAINING U 8 XII FEA SPTG DOC S .% 9,10 Xill TECH ASSESSMENT S U . XIV LIGHT FORCES S 11 XV CRMP U XVI ACRONYMS/ABBR U (ITt 7 - ; 1 T1’ l...development, and producto n of the AFV n accordance with the AFV requirement and contractual baseline. 3.14 AFV ACRMP I SEPTEMBER 87 ,p VOLUME XV, CI...SUMMARY THE ARMOR’ED FAMILY OF VEHICLES SYSTEM OVERVI EW - CHASSIS: HEV MDI7I LIGHT SUB- TANK IFV LOSAD HWTR LO SAPPER LOSAT REARM NBCRSjMS RECON CEM

  4. Analysis of interfractional set-up errors and intrafractional organ motions during IMRT for head and neck tumors to define an appropriate planning target volume (PTV)- and planning organs at risk volume (PRV)-margins.

    PubMed

    Suzuki, Minoru; Nishimura, Yasumasa; Nakamatsu, Kiyoshi; Okumura, Masahiko; Hashiba, Hisayuki; Koike, Ryuta; Kanamori, Shuichi; Shibata, Toru

    2006-03-01

    To analyze the interfractional set-up errors and intrafractional organ motions and to define appropriate planning target volume (PTV)- and planning organs at risk volume (PRV)-margins in intensity-modulated radiotherapy (IMRT) for head and neck tumors. Twenty-two patients with head and neck or brain tumors who were treated with IMRT were enrolled. The set-up errors were defined as the displacements of the coordinates of bony landmarks on the beam films from those on the simulation films. The organ motions were determined as the displacements of the coordinates of the landmarks on the images recorded every 3 min for 15 min on the X-ray simulator from those on the initial image. The standard deviations (SDs) of the systematic set-up errors (Sigma-INTER) and organ motions (Sigma-intra) distributed with a range of 0.7-1.3 and 0.2-0.8 mm, respectively. The average of the SDs of the random set-up errors (sigma-INTER) and organ motions (sigma-intra) ranged from 0.7 to 1.6 mm and from 0.3 to 0.6 mm, respectively. Appropriate PTV-margins and PRV-margins for all the landmarks ranged from 2.0 to 3.6 mm and from 1.8 to 2.4 mm, respectively. We have adopted a PTV-margin of 5mm and a PRV-margin of 3mm for head and neck IMRT at our department.

  5. Selected Bibliographies and State-of the-Art Review for Socio-cultural Factors in Health. Volume 4: Socio-cultural Factors in Health References. International Health Planning Reference Series.

    ERIC Educational Resources Information Center

    Fraser, Renee White; Shani, Hadasa

    Intended as a companion picce to volume 4 in the Method Series, Sociocultural Factors in Health Planning (CE 024 232), this fourth of six volumes in the International Health Planning Reference Series is a combined literature review and annotated bibliography dealing with social, cultural, and behavioral aspects of delivering, planning, and…

  6. Planning, Designing, Building, and Moving a Large Volume Maternity Service to a New Labor and Birth Unit.

    PubMed

    Thompson, Heather; Legorreta, Kimberly; Maher, Mary Ann; Lavin, Melanie M

    Our health system recognized the need to update facility space and associated technology for the labor and birth unit within our large volume perinatal service to improve the patient experience, and enhance safety, quality of care, and staff satisfaction. When an organization decides to invest $30 million dollars in a construction project such as a new labor and birth unit, many factors and considerations are involved. Financial support, planning, design, and construction phases of building a new unit are complex and therefore require strong interdisciplinary collaboration, leadership, and project management. The new labor and birth unit required nearly 3 years of planning, designing, and construction. Patient and family preferences were elicited through consumer focus groups. Multiple meetings with the administrative and nursing leadership teams, staff nurses, nurse midwives, and physicians were held to generate ideas for improvement in the new space. Involving frontline clinicians and childbearing women in the process was critical to success. The labor and birth unit moved to a new patient tower in a space that was doubled in square footage and geographically now on three separate floors. In the 6 months prior to the move, many efforts were made in our community to share our new space. The marketing strategy was very detailed and creative with ongoing input from the nursing leadership team. The nursing staff was involved in every step along the way. It was critical to have champions as workflow teams emerged. We hosted simulation drills and tested scenarios with new workflows. Move day was rehearsed with representatives of all members of the perinatal team participating. These efforts ultimately resulted in a move time of ~5 hours. Birth volumes increased 7% within the first 6 months. After 3 years in our new space, our birth volumes have risen nearly 15% and are still growing. Key processes and roles responsible for a successful build, efficient and safe move

  7. SU-E-T-294: Dosimetric Analysis of Planning Phase Using Overlap Volume Histogram for Respiratory Gated Radiotherapy

    SciTech Connect

    Kang, S; Kim, D; Kim, T; Shin, D; Cho, M; Kim, K; Suh, T; Kim, S; Park, S

    2015-06-15

    Purpose: End-of-exhale (EOE) phase is generally preferred for gating window because tumor position is more reproducible. However, other gating windows might be more appropriate for dose distribution perspective. In this pilot study, we proposed to utilize overlap volume histogram (OVH) to search optimized gating window and demonstrated its feasibility. Methods: We acquired 4DCT of 10 phases for 3 lung patients (2 with a target at right middle lobe and 1 at right upper lobe). After structures were defined in every phase, the OVH of each OAR was generated to quantify the three dimensional spatial relationship between the PTV and OARs (bronchus, esophagus, heart and cord etc.) at each phase. OVH tells the overlap volume of an OAR according to outward distance from the PTV. Relative overlap volume at 20 mm outward distance from the PTV (ROV-20) was also defined as a metric for measuring overlap volume and obtained. For dose calculation, 3D CRT plans were made for all phases under the same beam angles and objectives (e.g., 95% of the PTV coverage with at least 100% of the prescription dose of 50 Gy). The gating window phase was ranked according to ROV-20, and the relationship between the OVH and dose distribution at each phase was evaluated by comparing the maximum dose, mean dose, and equivalent uniform dose of OAR. Results: OVHs showed noticeable difference from phase to phase, implying it is possible to find optimal phases for gating window. For 2 out of 3 patients (both with a target at RML), maximum dose, mean dose, and EUD increased as ROV-20 increased. Conclusion: It is demonstrated that optimal phases (in dose distribution perspective) for gating window could exist and OVH can be a useful tool for determining such phases without performing dose optimization calculations in all phases. This work was supported by the Radiation Technology R&D program (No. 2013M2A2A7043498) and the Mid-career Researcher Program (2012-007883) through the National Research Foundation

  8. Climate program plan. Volume 1 of 2. [For assessing interrelationships between energy and climate

    SciTech Connect

    Not Available

    1980-01-01

    As part of the United States Climate Program Plan developed by the Interdepartmental Committee for Atmospheric Sciences, DOE is responsible for developing an understanding of and assessment capabilities for the effects of climate and climate fluctuations on man's generation of power, the effects of power generation and its various fuel processes and/or control technologies on climate, and development of blends of power generation and distribution modes that minimize adverse environmental and climatic effects. The DOE Climate Program Plan focuses on these three major roles in basic and applied research. The purpose of this document is to present background information relevant to these roles, to identify the perceived and potential effects of energy technologies on climate that now merit assessment, to define the need for research on the prediction of weather and climate variations and assessment of their effects on power production, and to outline research goals appropriate to the DOE mission. This report focuses on the need for assessing the cycles and budgets of the entire range of substances emitted in power production by the many technologies now in use. Emissions include but are not limited to /sup 85/Kr, particles, sulfur, and nitrogen oxides, waste heat, and hydrocarbons. To provide the basis for assessing the impacts of these emissions, this plan calls for specialized, mission-oriented research to improve understanding of processes that determine how these emissions are transported, transformed, and scavenged in the atmosphere, and of the natural processes that can be affectd by energy activities. This latter category includes potential modification of surface properties caused, for example, by large arrays of solar collectors, extensive biomass production, and wind power modification of the boundary layer. (JGB)

  9. ICESat (GLAS) Science Processing Software Document Series. Volume 1; Science Software Management Plan; 3.0

    NASA Technical Reports Server (NTRS)

    Hancock, David W., III

    1999-01-01

    This document provides the Software Management Plan for the GLAS Standard Data Software (SDS) supporting the GLAS instrument of the EOS ICESat Spacecraft. The SDS encompasses the ICESat Science Investigator-led Processing System (I-SIPS) Software and the Instrument Support Terminal (IST) Software. For the I-SIPS Software, the SDS will produce Level 0, Level 1, and Level 2 data products as well as the associated product quality assessments and descriptive information. For the IST Software, the SDS will accommodate the GLAS instrument support areas of engineering status, command, performance assessment, and instrument health status.

  10. The space shuttle payload planning working groups. Volume 7: Earth observations

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The findings of the Earth Observations working group of the space shuttle payload planning activity are presented. The objectives of the Earth Observation experiments are: (1) establishment of quantitative relationships between observable parameters and geophysical variables, (2) development, test, calibration, and evaluation of eventual flight instruments in experimental space flight missions, (3) demonstration of the operational utility of specific observation concepts or techniques as information inputs needed for taking actions, and (4) deployment of prototype and follow-on operational Earth Observation systems. The basic payload capability, mission duration, launch sites, inclinations, and payload limitations are defined.

  11. The space shuttle payload planning working groups: Volume 9: Materials processing and space manufacturing

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The findings and recommendations of the Materials Processing and Space Manufacturing group of the space shuttle payload planning activity are presented. The effects of weightlessness on the levitation processes, mixture stability, and control over heat and mass transport in fluids are considered for investigation. The research and development projects include: (1) metallurgical processes, (2) electronic materials, (3) biological applications, and (4)nonmetallic materials and processes. Additional recommendations are provided concerning the allocation of payload space, acceptance of experiments for flight, flight qualification, and private use of the space shuttle.

  12. Crop Identification Technolgy Assessment for Remote Sensing (CITARS). Volume 1: Task design plan

    NASA Technical Reports Server (NTRS)

    Hall, F. G.; Bizzell, R. M.

    1975-01-01

    A plan for quantifying the crop identification performances resulting from the remote identification of corn, soybeans, and wheat is described. Steps for the conversion of multispectral data tapes to classification results are specified. The crop identification performances resulting from the use of several basic types of automatic data processing techniques are compared and examined for significant differences. The techniques are evaluated also for changes in geographic location, time of the year, management practices, and other physical factors. The results of the Crop Identification Technology Assessment for Remote Sensing task will be applied extensively in the Large Area Crop Inventory Experiment.

  13. The space shuttle payload planning working groups. Volume 5: Solar physics

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The findings of the Solar Physics working group of the space shuttle payload planning activity are presented. The areas to be investigated by the solar physics experiments are: (1) the production of mechanical energy in the subphotospheric layers and its transport and dissipation in the upper layers of the atmosphere, (2) the mass flux from the subphotospheric layers into the chromosphere and corona and beyond the solar wind, (3) solar activity and its relationship to magnetic fields, and (4) the production of solar flares. The approach to be followed in conducting the experiments and the equipment required are defined.

  14. The space shuttle payload planning working groups. Volume 4: Life sciences

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The findings of the Life Sciences working group of the space shuttle payload planning activity are presented. The objectives of the Life Sciences investigations are: (1) to continue the research directed at understanding the origin of life and the search for extraterrestrial evidence of life, (2) biomedical research to understand mechanisms and provide criteria for support of manned flight, (3) technology development for life support, protective systems, and work aids for providing environmental control, and (4) to study basic biological functions at all levels or organization influenced by gravity, radiation, and circadian rhythms. Examples of candidate experimental schedules and the experimental package functional requirements are included.

  15. The space shuttle payload planning working groups. Volume 8: Earth and ocean physics

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The findings and recommendations of the Earth and Ocean Physics working group of the space shuttle payload planning activity are presented. The requirements for the space shuttle mission are defined as: (1) precision measurement for earth and ocean physics experiments, (2) development and demonstration of new and improved sensors and analytical techniques, (3) acquisition of surface truth data for evaluation of new measurement techniques, (4) conduct of critical experiments to validate geophysical phenomena and instrumental results, and (5) development and validation of analytical/experimental models for global ocean dynamics and solid earth dynamics/earthquake prediction. Tables of data are presented to show the flight schedule estimated costs, and the mission model.

  16. Scheduling Algorithm for Mission Planning and Logistics Evaluation (SAMPLE). Volume 3: The GREEDY algorithm

    NASA Technical Reports Server (NTRS)

    Dupnick, E.; Wiggins, D.

    1980-01-01

    The functional specifications, functional design and flow, and the program logic of the GREEDY computer program are described. The GREEDY program is a submodule of the Scheduling Algorithm for Mission Planning and Logistics Evaluation (SAMPLE) program and has been designed as a continuation of the shuttle Mission Payloads (MPLS) program. The MPLS uses input payload data to form a set of feasible payload combinations; from these, GREEDY selects a subset of combinations (a traffic model) so all payloads can be included without redundancy. The program also provides the user a tutorial option so that he can choose an alternate traffic model in case a particular traffic model is unacceptable.

  17. PLANS: A finite element program for nonlinear analysis of structures. Volume 1: Theoretical manual

    NASA Technical Reports Server (NTRS)

    Pifko, A.; Levine, H. S.; Armen, H., Jr.

    1975-01-01

    The PLANS system is described which is a finite element program for nonlinear analysis. The system represents a collection of special purpose computer programs each associated with a distinct physical problem class. Modules of PLANS specifically referenced and described in detail include: (1) REVBY, for the plastic analysis of bodies of revolution; (2) OUT-OF-PLANE, for the plastic analysis of 3-D built-up structures where membrane effects are predominant; (3) BEND, for the plastic analysis of built-up structures where bending and membrane effects are significant; (4) HEX, for the 3-D elastic-plastic analysis of general solids; and (5) OUT-OF-PLANE-MG, for material and geometrically nonlinear analysis of built-up structures. The SATELLITE program for data debugging and plotting of input geometries is also described. The theoretical foundations upon which the analysis is based are presented. Discussed are the form of the governing equations, the methods of solution, plasticity theories available, a general system description and flow of the programs, and the elements available for use.

  18. Large Deployable Reflector (LDR) system concept and technology definition study. Volume 2: Technology assessment and technology development plan

    NASA Technical Reports Server (NTRS)

    Agnew, Donald L.; Jones, Peter A.

    1989-01-01

    A study was conducted to define reasonable and representative LDR system concepts for the purpose of defining a technology development program aimed at providing the requisite technological capability necessary to start LDR development by the end of 1991. This volume presents thirteen technology assessments and technology development plans, as well as an overview and summary of the LDR concepts. Twenty-two proposed augmentation projects are described (selected from more than 30 candidates). The five LDR technology areas most in need of supplementary support are: cryogenic cooling; astronaut assembly of the optically precise LDR in space; active segmented primary mirror; dynamic structural control; and primary mirror contamination control. Three broad, time-phased, five-year programs were synthesized from the 22 projects, scheduled, and funding requirements estimated.

  19. Large Deployable Reflector (LDR) system concept and technology definition study. Volume 2: Technology assessment and technology development plan

    NASA Astrophysics Data System (ADS)

    Agnew, Donald L.; Jones, Peter A.

    1989-04-01

    A study was conducted to define reasonable and representative LDR system concepts for the purpose of defining a technology development program aimed at providing the requisite technological capability necessary to start LDR development by the end of 1991. This volume presents thirteen technology assessments and technology development plans, as well as an overview and summary of the LDR concepts. Twenty-two proposed augmentation projects are described (selected from more than 30 candidates). The five LDR technology areas most in need of supplementary support are: cryogenic cooling; astronaut assembly of the optically precise LDR in space; active segmented primary mirror; dynamic structural control; and primary mirror contamination control. Three broad, time-phased, five-year programs were synthesized from the 22 projects, scheduled, and funding requirements estimated.

  20. The model and the planning method of volume and variety assessment of innovative products in an industrial enterprise

    NASA Astrophysics Data System (ADS)

    Anisimov, V. G.; Anisimov, E. G.; Saurenko, T. N.; Sonkin, M. A.

    2017-01-01

    In the long term, the innovative development strategy efficiency is considered as the most crucial condition for assurance of economic system competitiveness in market conditions. It determines the problem relevance of such justification strategies with regard to specific systems features and conditions of their operation. The problem solution for industrial enterprises can be based on mathematical models of supporting the decision-making on the elements of the innovative manufacturing program. An optimization model and the planning method of innovative products volume and variety are suggested. The feature of the suggested model lies in the nonlinear nature of the objective function. It allows taking into consideration the law of diminishing marginal utility. The suggested method of optimization takes into account the system features and enables the effective implementation of manufacturing capabilities in modern conditions of production organization and sales in terms of market saturation.

  1. Sci—Fri AM: Mountain — 06: Optimizing planning target volume in lung radiotherapy using deformable registration

    SciTech Connect

    Hoang, P; Wierzbicki, M

    2014-08-15

    A four dimensional computed tomography (4DCT) image is acquired for all radically treated, lung cancer patients to define the internal target volume (ITV), which encompasses tumour motion due to breathing and subclinical disease. Patient set-up error and anatomical motion that is not due to breathing is addressed through an additional 1 cm margin around the ITV to obtain the planning target volume (PTV). The objective of this retrospective study is to find the minimum PTV margin that provides an acceptable probability of delivering the prescribed dose to the ITV. Acquisition of a kV cone beam computed tomography (CBCT) image at each fraction was used to shift the treatment couch to accurately align the spinal cord and carina. Our method utilized deformable image registration to automatically position the planning ITV on each CBCT. We evaluated the percentage of the ITV surface that fell within various PTVs for 79 fractions across 18 patients. Treatment success was defined as a situation where at least 99% of the ITV is covered by the PTV. Overall, this is to be achieved in at least 90% of the treatment fractions. The current approach with a 1cm PTV margin was successful ∼96% of the time. This analysis revealed that the current margin can be reduced to 0.8cm isotropic or 0.6×0.6×1 cm{sup 3} non-isotropic, which were successful 92 and 91 percent of the time respectively. Moreover, we have shown that these margins maintain accuracy, despite intrafractional variation, and maximize CBCT image guidance capabilities.

  2. SU-E-T-634: Analysis of Volume Based GYN HDR Brachytherapy Plans for Dose Calculation to Organs At Risk(OAR)

    SciTech Connect

    Nair, M; Li, C; White, M; Davis, J

    2014-06-15

    Purpose: We have analyzed the dose volume histogram of 140 CT based HDR brachytherapy plans and evaluated the dose received to OAR ; rectum, bladder and sigmoid colon based on recommendations from ICRU and Image guided brachytherapy working group for cervical cancer . Methods: Our treatment protocol consist of XRT to whole pelvis with 45 Gy at 1.8Gy/fraction followed by 30 Gy at 6 Gy per fraction by HDR brachytherapy in 2 weeks . The CT compatible tandem and ovoid applicators were used and stabilized with radio opaque packing material. The patient was stabilized using special re-locatable implant table and stirrups for reproducibility of the geometry during treatment. The CT scan images were taken at 3mm slice thickness and exported to the treatment planning computer. The OAR structures, bladder, rectum and sigmoid colon were outlined on the images along with the applicators. The prescription dose was targeted to A left and A right as defined in Manchester system and optimized on geometry . The dosimetry was compared on all plans using the parameter Ci.sec.cGy-1 . Using the Dose Volume Histogram (DVH) obtained from the plans the doses to rectum, sigmoid colon and bladder for ICRU defined points and 2cc volume were analyzed and reported. The following criteria were used for limiting the tolerance dose by volume (D2cc) were calculated. The rectum and sigmoid colon doses were limited to <75Gy. The bladder dose was limited to < 90Gy from both XRT and HDR brachytherapy. Results: The average total (XRT+HDRBT) BED values to prescription volume was 120 Gy. Dose 2cc to rectum was 70Gy +/− 17Gy, dose to 2cc bladder was 82+/−32 Gy. The average Ci.sec.cGy-1 calculated for the HDR plans was 6.99 +/− 0.5 Conclusion: The image based treatment planning enabled to evaluati volume based dose to critical structures for clinical interpretation.

  3. Planning the breast tumor bed boost: changes in the excision cavity volume and surgical scar location after breast-conserving surgery and whole-breast irradiation.

    PubMed

    Oh, Kevin S; Kong, Feng-Ming; Griffith, Kent A; Yanke, Beth; Pierce, Lori J

    2006-11-01

    The aims of this study were to determine the changes in breast and excision cavity volumes after whole-breast irradiation and the adequacy of using the surgical scar to guide boost planning. A total of 30 women consecutively treated for 31 breast cancers were included in this study. Simulation CT scans were performed before and after whole-breast irradiation. CT breast volumes were delineated using clinically defined borders. Excision cavity volumes were contoured based on surgical clips, the presence of a hematoma, and/or other surgical changes. Hypothetical electron boost plans were generated using the surgical scar with a 3-cm margin and analyzed for coverage. The mean CT breast volumes were 774 and 761 cc (p = 0.22), and the excision cavity volumes were 32.1 and 25.1 cc (p < 0.0001), before and after 40 Gy (39-42 Gy) of whole-breast irradiation, respectively. The volume reduction in the excision cavity was inversely correlated with time elapsed since surgery (R = 0.46, p < 0.01) and body weight (R = 0.50, p < 0.01). The scar-guided hypothetical plans failed to cover the excision cavity adequately in 62% and 53.8% of cases using the pretreatment and postradiation CTs, respectively. Per the hypothetical plans, the minimum dose to the excision cavity was significantly lower for tumors located in the inner vs. outer quadrants (p = 0.02) and for cavities >20 cc vs. <20 cc (p = 0.01). This study demonstrates a significant reduction in the volume of the excision cavity during whole-breast irradiation. Scar-guided boost plans provide inadequate coverage of the excision cavity in the majority of cases.

  4. Formulation of consumables management models. Volume 2: Mission planning processor user guide

    NASA Technical Reports Server (NTRS)

    Daly, J. K.; Torian, J. G.

    1978-01-01

    A user guide for the MPP (Mission Planning Processor) is presented. The MPP is used in the evaluation of particular missions, with appropriate display and storage of related consumables data. Design goals are accomplished by the use of an on-line/demand mode computer terminal Cathode Ray Tube Display. The process is such that the user merely adds specific mission/flight functions to a skeleton flight and/or alters the skeleton. The skeleton flight includes operational aspects from prelaunch through ground support equipment connect after rollout as required to place the STS (Space Transportation System) in a parking orbit, maintain the spacecraft and crew for the stated on-orbit period and return.

  5. Advanced Platform Systems Technology study. Volume 4: Technology advancement program plan

    NASA Technical Reports Server (NTRS)

    1983-01-01

    An overview study of the major technology definition tasks and subtasks along with their interfaces and interrelationships is presented. Although not specifically indicated in the diagram, iterations were required at many steps to finalize the results. The development of the integrated technology advancement plan was initiated by using the results of the previous two tasks, i.e., the trade studies and the preliminary cost and schedule estimates for the selected technologies. Descriptions for the development of each viable technology advancement was drawn from the trade studies. Additionally, a logic flow diagram depicting the steps in developing each technology element was developed along with descriptions for each of the major elements. Next, major elements of the logic flow diagrams were time phased, and that allowed the definition of a technology development schedule that was consistent with the space station program schedule when possible. Schedules show the major milestone including tests required as described in the logic flow diagrams.

  6. A Titan exploration study: Science, technology and mission planning options, volume 1

    NASA Technical Reports Server (NTRS)

    Tindle, E. L.; Manning, L. A.; Sadin, S. R.; Edsinger, L. E.; Weissman, P. R.; Swenson, B. L.

    1976-01-01

    Mission concepts and technology advancements that can be used in the exploration of the outer planet satellites were examined. Titan, the seventh satellite of Saturn was selected as the target of interest. Science objectives for Titan exploration were identified, and recommended science payloads for four basic mission modes were developed (orbiter, atmospheric probe, surface penetrator and lander). Trial spacecraft and mission designs were produced for the various mission modes. Using these trial designs as a base, technology excursions were then made to find solutions to the problems resulting from these conventional approaches and to uncover new science, technology and mission planning options. Several mission modes were developed that take advantage of the unique conditions expected at Titan. They include a combined orbiter, atmosphere probe and lander vehicle, a combined probe and surface penetrator configuration and concepts for advanced remote sensing orbiters.

  7. Tracking and data acquisition system for the 1990's. Volume 8: TDAS frequency planning

    NASA Technical Reports Server (NTRS)

    Heppe, S. B.; Elrod, B. D.

    1983-01-01

    Current planning calls for the TDAS to support new user and crosslink services, in addition to TDRSS-compatible services. TDRSS-compatible services would operate in current S-band and K-band channels used by TDRSS. New services, however, can take advantage of technology advances at microwave and optical frequencies. For augmented space-to-space services, 60 GHz and GaAs laser systems offer technical advantages, relative freedom from RFI, and a benign regulatory environment (i.e., minimal congestion and, in the case of 60 GHz, maximum regulatory support for TDAS-type services). For TDAS Earth-to-space and space-to-Earth services, the 30/20 GHz band offers the best mix of technical and regulatory advantages. But use of these bands would have to be coordinated with the U.S. military.

  8. MHD advanced power train. Phase 1, Final report: Volume 2, Development program plan

    SciTech Connect

    Jones, A.R.

    1985-08-01

    Two scale-up steps are required before the 200 MW(e) power plant could be designed and constructed. The development program plan is designed to meet these 3 needed program elements: (a) design and demonstration test of a 50 MW(t) power train that verifies channel life; (b) design, development, and demonstration of an advanced power train in a 250 MW(t) plant facility; and (c) development of technology for advanced MHD generators that are economic of magnet warm bore, reliable for at least 4000 hours operation, and are amenable to automated production to meet the low cost goal. An implicit program element, Base Technology, provides support to these 3 elements. The overall program will require 11 years and is estimated to cost $278 million in 1984 dollars.

  9. Department of Energy plan for recovery and utilization of nuclear byproducts from defense wastes. Volume 2

    SciTech Connect

    Not Available

    1983-08-01

    Nuclear wastes from the defense production cycle contain many uniquely useful, intrinsically valuable, and strategically important materials. These materials have a wide range of known and potential applications in food technology, agriculture, energy, public health, medicine, industrial technology, and national security. Furthermore, their removal from the nuclear waste stream can facilitate waste management and yield economic, safety, and environmental advantages in the management and disposal of the residual nuclear wastes that have no redemptive value. This document is the program plan for implementing the recovery and beneficial use of these valuable materials. An Executive Summary of this document, DOE/DP-0013, Vol. 1, January 1983, is available. Program policy, goals and strategy are stated in Section 2. Implementation tasks, schedule and funding are detailed in Section 3. The remaining five sections and the appendixes provide necessary background information to support these two sections. Section 4 reviews some of the unique properties of the individual byproduct materials and describes both demonstrated and potential applications. The amounts of byproduct materials that are available now for research and demonstration purposes, and the amounts that could be recovered in the future for expanded applications are detailed in Section 5. Section 6 describes the effects byproduct recovery and utilization have on the management and final disposal of nuclear wastes. The institutional issues that affect the recovery, processing and utilization of nuclear byproducts are discussed in Section 7. Finally, Section 8 presents a generalized mathematical process by which applications can be evaluated and prioritized (rank-ordered) to provide planning data for program management.

  10. Sparing Healthy Tissue and Increasing Tumor Dose Using Bayesian Modeling of Geometric Uncertainties for Planning Target Volume Personalization

    SciTech Connect

    Herschtal, Alan; Te Marvelde, Luc; Mengersen, Kerrie; Foroudi, Farshad; Eade, Thomas; Pham, Daniel; Caine, Hannah; Kron, Tomas

    2015-06-01

    Objective: To develop a mathematical tool that can update a patient's planning target volume (PTV) partway through a course of radiation therapy to more precisely target the tumor for the remainder of treatment and reduce dose to surrounding healthy tissue. Methods and Materials: Daily on-board imaging was used to collect large datasets of displacements for patients undergoing external beam radiation therapy for solid tumors. Bayesian statistical modeling of these geometric uncertainties was used to optimally trade off between displacement data collected from previously treated patients and the progressively accumulating data from a patient currently partway through treatment, to optimally predict future displacements for that patient. These predictions were used to update the PTV position and margin width for the remainder of treatment, such that the clinical target volume (CTV) was more precisely targeted. Results: Software simulation of dose to CTV and normal tissue for 2 real prostate displacement datasets consisting of 146 and 290 patients treated with a minimum of 30 fractions each showed that re-evaluating the PTV position and margin width after 8 treatment fractions reduced healthy tissue dose by 19% and 17%, respectively, while maintaining CTV dose. Conclusion: Incorporating patient-specific displacement patterns from early in a course of treatment allows PTV adaptation for the remainder of treatment. This substantially reduces the dose to healthy tissues and thus can reduce radiation therapy–induced toxicities, improving patient outcomes.

  11. [Comparison of the volume and localization of internal gross target volume and planning target volume delineated by clips and seroma based on 4D-CT scan for external-beam partial breast irradiation after breast conserving surgery].

    PubMed

    Ding, Yun; Li, Jianbin; Wang, Wei; Wang, Suzhen; Wang, Jinzhi; Ma, Zhifang

    2014-10-01

    To explore the differences in volume and localization of the internal gross target volume and planning target volume delineated by clips and/or seroma based on four-dimensional computed tomography (4D-CT) during free-breathing in breast cancer patients after breast conserving surgery. Fifteen breast cancer patients after breast-conserving surgery (BCS) were recruited for external-beam partial breast irradiation (EB-PBI). On the ten sets CT images, the gross tumor volumes (GTV) formed by the clips, the seroma, and both the clips and seroma were delineated and defined as GTVc, GTVs and GTVc+s, respectively. Ten GTVc, GTVs and GTVc+s on the ten sets CT images produced the IGTVc, IGTVs, IGTVc+s. The PTVc, PTVs, PTVc+s were created by adding 15 mm to the IGTVc, IGTVs, IGTVc+s, respectively. The IGTV and PTV volume and distance between the centers of IGTVc, IGTVs, IGTVc+s and PTVc, PTVs, PTVc+s were all recorded. Conformity index (CI) and degree of inclusion (DI) were calculated for IGTV/IGTV and PTV/PTV, respectively. The volume of IGTVc+s[(35.73 ± 19.77) cm³] was significantly larger than the IGTVc [(28.35 ± 17.54) cm³] and IGTVs [(24.19 ± 21.53) cm³] (P < 0.05), and the volume of PTVc+s [(191.59 ± 69.74) cm³] was significantly larger than that of the PTVc [(161.53 ± 61.07) cm³] and PTVs [(148.98 ± 62.22)cm³] (P < 0.05). There were significant differences between the DIs of IGTVc in IGTVc+s and IGTVc+s in IGTVc, the DIs of IGTVs in IGTVc+s and IGTVc+s in IGTVs, the DIs of PTVc in PTVc+s and PTVc+s in PTVc, and the DIs of PTVs vs. PTVc+s and PTVc+s in PTVs (P < 0.05 for all). The CI of IGTVc/IGTVc+s (0.63 ± 0.14) and the CI of IGTVs/IGTVc+s (0.54 ± 0.17) were significant larger than that of the CI of IGTVc/IGTVs (0.40 ± 0.14)(P < 0.05). There were non-significant differences among the CI of PTVc/PTVs, PTVc/PTVc+s and PTVs/PTVc+s (0.73 ± 0.12, 0.78 ± 0.13 vs. 0.75 ± 0.17). The DIs and CIs of IGTV/IGTV and PTV/PTV were negatively correlated with their

  12. Comparative evaluation of target volumes defined by deformable and rigid registration of diagnostic PET/CT to planning CT in primary esophageal cancer.

    PubMed

    Guo, Yanluan; Li, Jianbin; Zhang, Peng; Shao, Qian; Xu, Min; Li, Yankang

    2017-01-01

    To evaluate the geometrical differences of target volumes propagated by deformable image registration (DIR) and rigid image registration (RIR) to assist target volume delineation between diagnostic Positron emission tomography/computed tomography (PET/CT) and planning CT for primary esophageal cancer (EC). Twenty-five patients with EC sequentially underwent a diagnostic F-fluorodeoxyglucose (F-FDG) PET/CT scan and planning CT simulation. Only 19 patients with maximum standardized uptake value (SUVmax) ≥ 2.0 of the primary volume were available. Gross tumor volumes (GTVs) were delineated using CT and PET display settings. The PET/CT images were then registered with planning CT using MIM software. Subsequently, the PET and CT contours were propagated by RIR and DIR to planning CT. The properties of these volumes were compared. When GTVCT delineated on CT of PET/CT after both RIR and DIR was compared with GTV contoured on planning CT, significant improvements using DIR were observed in the volume, displacements of the center of mass (COM) in the 3-dimensional (3D) direction, and Dice similarity coefficient (DSC) (P = 0.003; 0.006; 0.014). Although similar improvements were not observed for the same comparison using DIR for propagated PET contours from diagnostic PET/CT to planning CT (P > 0.05), for DSC and displacements of COM in the 3D direction of PET contours, the DIR resulted in the improved volume of a large percentage of patients (73.7%; 68.45%; 63.2%) compared with RIR. For diagnostic CT-based contours or PET contours at SUV2.5 propagated by DIR with planning CT, the DSC and displacements of COM in 3D directions in the distal segment were significantly improved compared to the upper and middle segments (P > 0.05). We observed a trend that deformable registration might improve the overlap for gross target volumes from diagnostic PET/CT to planning CT. The distal EC might benefit more from DIR.

  13. Comparative evaluation of target volumes defined by deformable and rigid registration of diagnostic PET/CT to planning CT in primary esophageal cancer

    PubMed Central

    Guo, Yanluan; Li, Jianbin; Zhang, Peng; Shao, Qian; Xu, Min; Li, Yankang

    2017-01-01

    Abstract Background: To evaluate the geometrical differences of target volumes propagated by deformable image registration (DIR) and rigid image registration (RIR) to assist target volume delineation between diagnostic Positron emission tomography/computed tomography (PET/CT) and planning CT for primary esophageal cancer (EC). Methods: Twenty-five patients with EC sequentially underwent a diagnostic 18F-fluorodeoxyglucose (18F-FDG) PET/CT scan and planning CT simulation. Only 19 patients with maximum standardized uptake value (SUVmax) ≥ 2.0 of the primary volume were available. Gross tumor volumes (GTVs) were delineated using CT and PET display settings. The PET/CT images were then registered with planning CT using MIM software. Subsequently, the PET and CT contours were propagated by RIR and DIR to planning CT. The properties of these volumes were compared. Results: When GTVCT delineated on CT of PET/CT after both RIR and DIR was compared with GTV contoured on planning CT, significant improvements using DIR were observed in the volume, displacements of the center of mass (COM) in the 3-dimensional (3D) direction, and Dice similarity coefficient (DSC) (P = 0.003; 0.006; 0.014). Although similar improvements were not observed for the same comparison using DIR for propagated PET contours from diagnostic PET/CT to planning CT (P > 0.05), for DSC and displacements of COM in the 3D direction of PET contours, the DIR resulted in the improved volume of a large percentage of patients (73.7%; 68.45%; 63.2%) compared with RIR. For diagnostic CT-based contours or PET contours at SUV2.5 propagated by DIR with planning CT, the DSC and displacements of COM in 3D directions in the distal segment were significantly improved compared to the upper and middle segments (P > 0.05). Conclusion: We observed a trend that deformable registration might improve the overlap for gross target volumes from diagnostic PET/CT to planning CT. The distal EC might benefit more from DIR

  14. Impact of 18FDG-PET/CT on biological target volume (BTV) definition for treatment planning for non-small cell lung cancer patients

    NASA Astrophysics Data System (ADS)

    Devic, Slobodan; Tomic, Nada; Faria, Sergio; Dean, Geoffrey; Lisbona, Robert; Parker, William; Kaufman, Chris; Podgorsak, Ervin B.

    2007-02-01

    This work represents our effort to test feasibility of FDG-based PET/CT on target volume delineation in radiotherapy treatment planning of NSCLC patients. Different methods have been developed to enable more precise target outlining using PET: Qualitative Visual Method, CTV=2.5 SUV units, linear SUV threshold function method, and CTV=40% Iso of Maximum Uptake Value. We are proposing reconstruction of three biological target volumes: necrotic BTV (same as PTV created by radiation oncologist using CT data), proliferating BTV (based on PET signal to background ratio 1:3) and hypoxic BTV (based on PET signal to background ratio of 1:19). Two IMRT plans were created and compared to the conventional treatment plan: "conservative" IMRT plan delivers 52.5 Gy to the necrotic BTV and 65 Gy to the hypoxic BTV; "radical" IMRT plan delivers 30 Gy to necrotic BTV, 52.5 Gy to proliferating BTV and 65 Gy to hypoxic BTV. Use of BTVs in IMRT plans is attractive because it increases dose to targets considered to need higher doses. It reduces considerably dose to heart and spinal cord, organs considered to limit dose escalation approaches in NSCLC treatment. "Conservative" IMRT approach can be understood as a PET/CT-based concomitant boost to the tumor expressing the highest FDG uptake. "Radical" plan implies deviation from the traditional uniform dose target coverage approach, with the intention of achieving better surrounding tissue sparing and ultimately allowing for dose escalation protocols relying on biologically based treatment planning.

  15. Acoustic Treatment Design Scaling Methods. Volume 3; Test Plans, Hardware, Results, and Evaluation

    NASA Technical Reports Server (NTRS)

    Yu, J.; Kwan, H. W.; Echternach, D. K.; Kraft, R. E.; Syed, A. A.

    1999-01-01

    The ability to design, build, and test miniaturized acoustic treatment panels on scale-model fan rigs representative of the full-scale engine provides not only a cost-savings, but an opportunity to optimize the treatment by allowing tests of different designs. To be able to use scale model treatment as a full-scale design tool, it is necessary that the designer be able to reliably translate the scale model design and performance to an equivalent full-scale design. The primary objective of the study presented in this volume of the final report was to conduct laboratory tests to evaluate liner acoustic properties and validate advanced treatment impedance models. These laboratory tests include DC flow resistance measurements, normal incidence impedance measurements, DC flow and impedance measurements in the presence of grazing flow, and in-duct liner attenuation as well as modal measurements. Test panels were fabricated at three different scale factors (i.e., full-scale, half-scale, and one-fifth scale) to support laboratory acoustic testing. The panel configurations include single-degree-of-freedom (SDOF) perforated sandwich panels, SDOF linear (wire mesh) liners, and double-degree-of-freedom (DDOF) linear acoustic panels.

  16. Dose as a Function of Lung Volume and Planned Treatment Volume in Helical Tomotherapy Intensity-Modulated Radiation Therapy-Based Stereotactic Body Radiation Therapy for Small Lung Tumors

    SciTech Connect

    Baisden, Joseph M.; Romney, Davis A.; Reish, Andrew G.; Cai Jing; Sheng Ke; Jones, David R.; Benedict, Stanley H.; Read, Paul W.; Larner, James M. . E-mail: JML2P@virginia.edu

    2007-07-15

    Purpose: To evaluate the limitations of Hi-Art Helical Tomotherapy (Middleton, WI) stereotactic body radiotherapy (SBRT) for lung lesions, and to provide an initial report on patients treated with this method. Stereotactic body radiotherapy was shown to be an effective, well-tolerated treatment for early-stage, non-small-cell lung carcinoma (NSCLC). The Radiation Therapy Oncology Group (RTOG) 0236 protocol is currently evaluating three-dimensional conformal SBRT that delivers 60 Gy in three fractions. Methods and Materials: Inverse treatment planning for hypothetical lung gross tumor volumes (GTV) and planned treatment volume (PTV) expansions were performed. We tested the hypothesis that the maximum acceptable dose (MAD) to be delivered to the lesion by SBRT could be predicted by PTV and lung volume. Dose constraints on normal tissue were as designated by the RTOG protocol. Inverse planning was performed to find the maximum tolerated SBRT dose up to 60 Gy. Results: Regression analysis of the data obtained indicated a linear relationship between MAD, PTV, and lung volume. This generated two equations which may be useful predictive tools. Seven patients with Stage I and II NSCLC treated at University of Virginia with this method tolerated the treatment extremely well, and suffered no greater than grade I toxicity, with no evidence of disease recurrence in follow-up from 2-20 months. Conclusions: Helical tomotherapy SBRT for lung lesions is well-tolerated. In addition, the likely MAD for patients considered for this type of treatment can be predicted by PTV and lung volume.

  17. Generation IV Nuclear Energy Systems Ten-Year Program Plan Fiscal Year 2005, Volume 1

    SciTech Connect

    2005-03-01

    As reflected in the U.S. ''National Energy Policy'', nuclear energy has a strong role to play in satisfying our nation's future energy security and environmental quality needs. The desirable environmental, economic, and sustainability attributes of nuclear energy give it a cornerstone position, not only in the U.S. energy portfolio, but also in the world's future energy portfolio. Accordingly, on September 20, 2002, U.S. Energy Secretary Spencer Abraham announced that, ''The United States and nine other countries have agreed to develop six Generation IV nuclear energy concepts''. The Secretary also noted that the systems are expected to ''represent significant advances in economics, safety, reliability, proliferation resistance, and waste minimization''. The six systems and their broad, worldwide research and development (R&D) needs are described in ''A Technology Roadmap for Generation IV Nuclear Energy Systems'' (hereafter referred to as the Generation IV Roadmap). The first 10 years of required U.S. R&D contributions to achieve the goals described in the Generation IV Roadmap are outlined in this Program Plan.

  18. Resource management plan for the Oak Ridge Reservation: Volume 24, Threatened and endangered animal species

    SciTech Connect

    Kroodsma, R.L.

    1987-01-01

    United States and Tennessee laws provide protection for wildlife species that the US Fish and Wildlife Service (FWS) and the Tennessee Wildlife Resources Agency (TWRA) have determined to be endangered or threatened. These laws and their implications for management of the Oak Ridge Reservation (ORR) are briefly discussed. The historical occurrence, current status, and recommended surveys and management plans for all threatened and endangered (T and E) wildlife species with a reasonable probability of occurring on the ORR are also discussed. Seventeen species of T and E mollusks historically occurred in the Oak Ridge area, but no management action is recommended because reservoir construction and other factors not related to Department of Energy operations have eliminated suitable habitat. Systematic surveys and management actions are also not recommended for three species of T and E fish, one amphibian species, one reptile species, six bird species, and two mammal species because of the very low potential for the occurrence of these species on the ORR. For three T and E bird species on the ORR, no feasible or significantly beneficial management actions could be identified. Surveys and consideration of possible management actions are recommended for three state-listed bird species that occur on or near the ORR and for two federally listed bat species that occur in East Tennessee and may occur on the ORR.

  19. Effect of various methods for rectum delineation on relative and absolute dose-volume histograms for prostate IMRT treatment planning

    SciTech Connect

    Kusumoto, Chiaki; Ohira, Shingo; Miyazaki, Masayoshi; Ueda, Yoshihiro; Isono, Masaru; Teshima, Teruki

    2016-07-01

    Several reports have dealt with correlations of late rectal toxicity with rectal dose-volume histograms (DVHs) for high dose levels. There are 2 techniques to assess rectal volume for reception of a specific dose: relative-DVH (R-DVH, %) that indicates relative volume for a vertical axis, and absolute-DVH (A-DVH, cc) with its vertical axis showing absolute volume of the rectum. The parameters of DVH vary depending on the rectum delineation method, but the literature does not present any standardization of such methods. The aim of the present study was to evaluate the effects of different delineation methods on rectal DVHs. The enrollment for this study comprised 28 patients with high-risk localized prostate cancer, who had undergone intensity-modulated radiation therapy (IMRT) with the prescription dose of 78 Gy. The rectum was contoured with 4 different methods using 2 lengths, short (Sh) and long (Lg), and 2 cross sections, rectum (Rec) and rectal wall (Rw). Sh means the length from 1 cm above the seminal vesicles to 1 cm below the prostate and Lg the length from the rectosigmoid junction to the anus. Rec represents the entire rectal volume including the rectal contents and Rw the rectal volume of the area with a wall thickness of 4 mm. We compared dose-volume parameters by using 4 rectal contour methods for the same plan with the R-DVHs as well as the A-DVHs. For the high dose levels, the R-DVH parameters varied widely. The mean of V{sub 70} for Sh-Rw was the highest (19.4%) and nearly twice as high as that for Lg-Rec (10.4%). On the contrary, only small variations were observed in the A-DVH parameters (4.3, 4.3, 5.5, and 5.5 cc for Sh-Rw, Lg-Rw, Sh-Rec, and Lg-Rec, respectively). As for R-DVHs, the parameters of V{sub 70} varied depending on the rectal lengths (Sh-Rec vs Lg-Rec: R = 0.76; Sh-Rw vs Lg-Rw: R = 0.85) and cross sections (Sh-Rec vs Sh-Rw: R = 0.49; Lg-Rec vs Lg-Rw: R = 0.65). For A-DVHs, however, the parameters of Sh rectal A-DVHs hardly changed

  20. A novel convolution-based approach to address ionization chamber volume averaging effect in model-based treatment planning systems

    NASA Astrophysics Data System (ADS)

    Barraclough, Brendan; Li, Jonathan G.; Lebron, Sharon; Fan, Qiyong; Liu, Chihray; Yan, Guanghua

    2015-08-01

    The ionization chamber volume averaging effect is a well-known issue without an elegant solution. The purpose of this study is to propose a novel convolution-based approach to address the volume averaging effect in model-based treatment planning systems (TPSs). Ionization chamber-measured beam profiles can be regarded as the convolution between the detector response function and the implicit real profiles. Existing approaches address the issue by trying to remove the volume averaging effect from the measurement. In contrast, our proposed method imports the measured profiles directly into the TPS and addresses the problem by reoptimizing pertinent parameters of the TPS beam model. In the iterative beam modeling process, the TPS-calculated beam profiles are convolved with the same detector response function. Beam model parameters responsible for the penumbra are optimized to drive the convolved profiles to match the measured profiles. Since the convolved and the measured profiles are subject to identical volume averaging effect, the calculated profiles match the real profiles when the optimization converges. The method was applied to reoptimize a CC13 beam model commissioned with profiles measured with a standard ionization chamber (Scanditronix Wellhofer, Bartlett, TN). The reoptimized beam model was validated by comparing the TPS-calculated profiles with diode-measured profiles. Its performance in intensity-modulated radiation therapy (IMRT) quality assurance (QA) for ten head-and-neck patients was compared with the CC13 beam model and a clinical beam model (manually optimized, clinically proven) using standard Gamma comparisons. The beam profiles calculated with the reoptimized beam model showed excellent agreement with diode measurement at all measured geometries. Performance of the reoptimized beam model was comparable with that of the clinical beam model in IMRT QA. The average passing rates using the reoptimized beam model increased substantially from 92.1% to

  1. A novel convolution-based approach to address ionization chamber volume averaging effect in model-based treatment planning systems.

    PubMed

    Barraclough, Brendan; Li, Jonathan G; Lebron, Sharon; Fan, Qiyong; Liu, Chihray; Yan, Guanghua

    2015-08-21

    The ionization chamber volume averaging effect is a well-known issue without an elegant solution. The purpose of this study is to propose a novel convolution-based approach to address the volume averaging effect in model-based treatment planning systems (TPSs). Ionization chamber-measured beam profiles can be regarded as the convolution between the detector response function and the implicit real profiles. Existing approaches address the issue by trying to remove the volume averaging effect from the measurement. In contrast, our proposed method imports the measured profiles directly into the TPS and addresses the problem by reoptimizing pertinent parameters of the TPS beam model. In the iterative beam modeling process, the TPS-calculated beam profiles are convolved with the same detector response function. Beam model parameters responsible for the penumbra are optimized to drive the convolved profiles to match the measured profiles. Since the convolved and the measured profiles are subject to identical volume averaging effect, the calculated profiles match the real profiles when the optimization converges. The method was applied to reoptimize a CC13 beam model commissioned with profiles measured with a standard ionization chamber (Scanditronix Wellhofer, Bartlett, TN). The reoptimized beam model was validated by comparing the TPS-calculated profiles with diode-measured profiles. Its performance in intensity-modulated radiation therapy (IMRT) quality assurance (QA) for ten head-and-neck patients was compared with the CC13 beam model and a clinical beam model (manually optimized, clinically proven) using standard Gamma comparisons. The beam profiles calculated with the reoptimized beam model showed excellent agreement with diode measurement at all measured geometries. Performance of the reoptimized beam model was comparable with that of the clinical beam model in IMRT QA. The average passing rates using the reoptimized beam model increased substantially from 92.1% to

  2. Hip segmentation from MRI volumes in infants for DDH diagnosis and treatment planning.

    PubMed

    Hareendranathan, Abhilash Rakkunedeth; Zonoobi, Dornoosh; Mabee, Myles; Diederichs, Chad; Punithakumar, Kumaradevan; Noga, Michelle; Jaremko, Jacob L

    2016-08-01

    Diagnosis and surgical management of Developmental Dysplasia of the Hip (DDH) relies on physical examination and 2D ultrasound scanning. Magnetic Resonance Imaging (MRI) can be used to complement existing techniques and could be advantageous in treatment planning due to its larger field of view. In this paper we propose a semi-automatic method to segment surface models of the acetabulum from MRI images. The method incorporates clinical knowledge in the form of intensity priors which are integrated into a Random Walker (RW) formulation. We use a modified RW framework which compensates for incomplete or blurred boundaries in the image by using information from neighboring slices in the sequence incorporated as node weights. We conducted a pilot study to evaluate the segmentation on a set of 10 infant hip MRI sequences using a 1.5 Tesla MR scanner. Contours obtained from the semi-automated segmentation were compared against manually segmented hip contours using Dice Ratio (DR), Hausdorff Distance (HD) and Root Mean Square (RMS) distance. The proposed method gave values of (DR = 0.84 ± 0.5, HD =3.0 ± 0.7, RMS =1.9 ± 0.3) and (DR=0.86 ± 0.2, HD=3.0 ± 0.1, RMS= 2.0 ± 0.6) for right and left acetabular contours respectively which was higher than the corresponding values obtained from conventional RW segmentation. The execution time of the segmentation algorithm was less than ~4 seconds on a 3.5 GHz CPU.

  3. Task Analysis and Descriptions of Required Job Competencies for Robotics/Automated Systems Technicians. Final Report. Volume 2. Curriculum Planning Guide.

    ERIC Educational Resources Information Center

    Hull, Daniel M.; Lovett, James E.

    This volume of the final report for the Robotics/Automated Systems Technician (RAST) curriculum project is a curriculum planning guide intended for school administrators, faculty, and student counselors/advisors. It includes step-by-step procedures to help institutions evaluate their community's needs and their capabilities to meet these needs in…

  4. Distance-to-Agreement Investigation of Tomotherapy's Bony Anatomy-Based Autoregistration and Planning Target Volume Contour-Based Optimization

    SciTech Connect

    Suh, Steve; Schultheiss, Timothy E.

    2013-03-01

    Purpose: To compare Tomotherapy's megavoltage computed tomography bony anatomy autoregistration with the best achievable registration, assuming no deformation and perfect knowledge of planning target volume (PTV) location. Methods and Materials: Distance-to-agreement (DTA) of the PTV was determined by applying a rigid-body shift to the PTV region of interest of the prostate from its reference position, assuming no deformations. Planning target volume region of interest of the prostate was extracted from the patient archives. The reference position was set by the 6 degrees of freedom (dof)—x, y, z, roll, pitch, and yaw—optimization results from the previous study at this institution. The DTA and the compensating parameters were calculated by the shift of the PTV from the reference 6-dof to the 4-dof—x, y, z, and roll—optimization. In this study, the effectiveness of Tomotherapy's 4-dof bony anatomy–based autoregistration was compared with the idealized 4-dof PTV contour-based optimization. Results: The maximum DTA (maxDTA) of the bony anatomy-based autoregistration was 3.2 ± 1.9 mm, with the maximum value of 8.0 mm. The maxDTA of the contour-based optimization was 1.8 ± 1.3 mm, with the maximum value of 5.7 mm. Comparison of Pearson correlation of the compensating parameters between the 2 4-dof optimization algorithms shows that there is a small but statistically significant correlation in y and z (0.236 and 0.300, respectively), whereas there is very weak correlation in x and roll (0.062 and 0.025, respectively). Conclusions: We find that there is an average improvement of approximately 1 mm in terms of maxDTA on the PTV going from 4-dof bony anatomy-based autoregistration to the 4-dof contour-based optimization. Pearson correlation analysis of the 2 4-dof optimizations suggests that uncertainties due to deformation and inadequate resolution account for much of the compensating parameters, but pitch variation also makes a statistically significant

  5. Design and development of Stirling engines for stationary power generation applications in the 500 to 3000 horsepower range. Volume 2. Program plan

    SciTech Connect

    Not Available,

    1980-09-15

    A plan for implementing the proposed state-of-the-art design described in Volume I has been developed. The main objective of the project is to demonstrate a large coal-fired Stirling engine and thus shorten the lead time to commercialization. The demonstration engine will be based on the concepts developed in the first phase of this program, as detailed in Volume I of this report. Thus the proposed program plan is based on the U-4 engine concept fired by a fluidized bed combustor with a two-stage gravity-assisted heat pipe. The plan is divided into five phases and an ongoing supporting technology program. Phase I, Conceptual Design, has been completed. The remaining phases are: Preliminary Design; Final Design; Fabrication; and Testing and Demonstration. The primary target is to begin testing the large coal-fired engine by the fifth year (1985) after the start of Preliminary Design.

  6. Treatment Planning and Volumetric Response Assessment for Yttrium-90 Radioembolization: Semiautomated Determination of Liver Volume and Volume of Tumor Necrosis in Patients with Hepatic Malignancy

    SciTech Connect

    Monsky, Wayne L.; Garza, Armando S.; Kim, Isaac; Loh, Shaun; Lin, Tzu-Chun; Li Chinshang; Fisher, Jerron; Sandhu, Parmbir; Sidhar, Vishal; Chaudhari, Abhijit J.; Lin, Frank; Deutsch, Larry-Stuart; Badawi, Ramsey D.

    2011-04-15

    Purpose: The primary purpose of this study was to demonstrate intraobserver/interobserver reproducibility for novel semiautomated measurements of hepatic volume used for Yttrium-90 dose calculations as well as whole-liver and necrotic-liver (hypodense/nonenhancing) tumor volume after radioembolization. The secondary aim was to provide initial comparisons of tumor volumetric measurements with linear measurements, as defined by Response Evaluation Criteria in Solid Tumors criteria, and survival outcomes. Methods: Between 2006 and 2009, 23 consecutive radioembolization procedures were performed for 14 cases of hepatocellular carcinoma and 9 cases of hepatic metastases. Baseline and follow-up computed tomography obtained 1 month after treatment were retrospectively analyzed. Three observers measured liver, whole-tumor, and tumor-necrosis volumes twice using semiautomated software. Results: Good intraobserver/interobserver reproducibility was demonstrated (intraclass correlation [ICC] > 0.9) for tumor and liver volumes. Semiautomated measurements of liver volumes were statistically similar to those obtained with manual tracing (ICC = 0.868), but they required significantly less time to perform (p < 0.0001, ICC = 0.088). There was a positive association between change in linear tumor measurements and whole-tumor volume (p < 0.0001). However, linear measurements did not correlate with volume of necrosis (p > 0.05). Dose, change in tumor diameters, tumor volume, and necrotic volume did not correlate with survival (p > 0.05 in all instances). However, Kaplan-Meier curves suggest that a >10% increase in necrotic volume correlated with survival (p = 0.0472). Conclusion: Semiautomated volumetric analysis of liver, whole-tumor, and tumor-necrosis volume can be performed with good intraobserver/interobserver reproducibility. In this small retrospective study, measurements of tumor necrosis were suggested to correlate with survival.

  7. Defining the Optimal Planning Target Volume in Image-Guided Stereotactic Radiosurgery of Brain Metastases: Results of a Randomized Trial

    SciTech Connect

    Kirkpatrick, John P.; Wang, Zhiheng; Sampson, John H.; McSherry, Frances; Herndon, James E.; Allen, Karen J.; Duffy, Eileen; Hoang, Jenny K.; Chang, Zheng; Yoo, David S.; Kelsey, Chris R.; Yin, Fang-Fang

    2015-01-01

    Purpose: To identify an optimal margin about the gross target volume (GTV) for stereotactic radiosurgery (SRS) of brain metastases, minimizing toxicity and local recurrence. Methods and Materials: Adult patients with 1 to 3 brain metastases less than 4 cm in greatest dimension, no previous brain radiation therapy, and Karnofsky performance status (KPS) above 70 were eligible for this institutional review board–approved trial. Individual lesions were randomized to 1- or 3- mm uniform expansion of the GTV defined on contrast-enhanced magnetic resonance imaging (MRI). The resulting planning target volume (PTV) was treated to 24, 18, or 15 Gy marginal dose for maximum PTV diameters less than 2, 2 to 2.9, and 3 to 3.9 cm, respectively, using a linear accelerator–based image-guided system. The primary endpoint was local recurrence (LR). Secondary endpoints included neurocognition Mini-Mental State Examination, Trail Making Test Parts A and B, quality of life (Functional Assessment of Cancer Therapy-Brain), radionecrosis (RN), need for salvage radiation therapy, distant failure (DF) in the brain, and overall survival (OS). Results: Between February 2010 and November 2012, 49 patients with 80 brain metastases were treated. The median age was 61 years, the median KPS was 90, and the predominant histologies were non–small cell lung cancer (25 patients) and melanoma (8). Fifty-five, 19, and 6 lesions were treated to 24, 18, and 15 Gy, respectively. The PTV/GTV ratio, volume receiving 12 Gy or more, and minimum dose to PTV were significantly higher in the 3-mm group (all P<.01), and GTV was similar (P=.76). At a median follow-up time of 32.2 months, 11 patients were alive, with median OS 10.6 months. LR was observed in only 3 lesions (2 in the 1 mm group, P=.51), with 6.7% LR 12 months after SRS. Biopsy-proven RN alone was observed in 6 lesions (5 in the 3-mm group, P=.10). The 12-month DF rate was 45.7%. Three months after SRS, no significant change in

  8. Comparison of planning target volumes based on three-dimensional and four-dimensional CT imaging of thoracic esophageal cancer.

    PubMed

    Wang, Wei; Li, Jianbin; Zhang, Yingjie; Shao, Qian; Xu, Min; Fan, Tingyong; Wang, Jinzhi

    2016-01-01

    To investigate the definition of planning target volumes (PTVs) based on four-dimensional computed tomography (4DCT) compared with conventional PTV definition and PTV definition using asymmetrical margins for thoracic primary esophageal cancer. Forty-three patients with esophageal cancer underwent 3DCT and 4DCT simulation scans during free breathing. The motions of primary tumors located in the proximal (group A), middle (group B), and distal (group C) thoracic esophagus were obtained from the 4DCT scans. PTV3D was defined on 3DCT using the tumor motion measured based on 4DCT, PTV conventional (PTVconv) was defined on 3DCT by adding a 1.0 cm margin to the clinical target volume, and PTV4D was defined as the union of the target volumes contoured on the ten phases of the 4DCT images. The centroid positions, volumetric differences, and dice similarity coefficients were evaluated for all PTVs. The median centroid shifts between PTV3D and PTV4D and between PTVconv and PTV4D in all three dimensions were <0.3 cm for the three groups. The median size ratios of PTV4D to PTV3D were 0.80, 0.88, and 0.71, and PTV4D to PTVconv were 0.67, 0.73, and 0.76 (χ (2)=-3.18, -2.98, and -3.06; P=0.001, 0.003, and 0.002) for groups A, B, and C, respectively. The dice similarity coefficients were 0.87, 0.90, and 0.81 between PTV4D and PTV3D and 0.80, 0.84, and 0.83 between PTV4D and PTVconv (χ (2) =-3.18, -2.98, and -3.06; P=0.001, 0.003, and 0.002) for groups A, B, and C, respectively. The difference between the degree of inclusion of PTV4D in PTV3D and that of PTV4D in PTVconv was <2% for all groups. Compared with PTVconv, the amount of irradiated normal tissue for PTV3D was decreased by 11.81% and 11.86% in groups A and B, respectively, but was increased by 2.93% in group C. For proximal and middle esophageal cancer, 3DCT-based PTV using asymmetrical margins provides good coverage of PTV4D; however, for distal esophageal cancer, 3DCT-based PTV using conventional margins provides ideal

  9. A method to obtain correct standard uptake values in Pinnacle treatment planning system for target volume delineation.

    PubMed

    Salehzahi, Farshid; Tse, Jason; Lee, Jonathan; Selvaraj, Jothybasu

    2016-01-01

    Standardized uptake value (SUV) is an advanced tool for quantitative tumor identification and metabolic target volume delineation (TVD) in diagnostic and therapeutic settings. It is thus important to establish a quality assured process to maintain the traceability of data correctly by positron emission tomography (PET) systems. Patient administration of (18)fluoro-deoxy-glucose is increasingly delivered by automated infusion systems (AISs). Whenever AIS is used, its accuracy and traceability measurement need verification. In addition, it was observed that the unreproducible SUV displayed in PET and the treatment planning system (TPS) may cause grave concerns for radiation oncologists for TVD. This concern may complicate the correlation of TVD on PET and TPS and their clinical reporting. The SUV traceability was established from the PET system to AIS. Its accuracy was verified by cross-referencing to the reference dose calibrator traceable to a primary standard. The SUV values were converted in TPS using the in-house "clinical tool" to be identical as in PET, to allow radiation oncologists to use SUV confidently. The outcome of this study enables the clinical groups to rely on the correct SUV values displayed on the TPS and to improve the quality of care for patients in clinical procedures.

  10. Development of whole-building energy design targets for commercial buildings: Phase 1, Planning: Volume 2, Technical report

    SciTech Connect

    Crawley, D.B.; Briggs, R.S.; Jones, J.W.; Seaton, W.W.; Kaufman, J.E.; Deringer, J.J.; Kennett, E.W.

    1987-08-01

    This is the second volume of the Phase 1 report and discusses the 10 tasks performed in Phase 1. The objective of this research is to develop a methodology for setting energy design targets to provide voluntary guidelines for the buildings industry. The whole-building energy targets project is being conducted at the Pacific Northwest Laboratory (PNL) for the US Department of Energy (DOE) to encourage the construction of energy-efficient buildings by informing designers and owners about cost-effective goals for energy use in new commercial buildings. The outcome of this research will be a flexible methodology for setting such targets. The tasks are listed and discussed in this report as follows: Task 1 - Develop Detailed Project Goals and Objectives; Task 2 - Establish Buildings-Industry Liaison; Task 3 - Develop Approaches to the Energy Targets Model, Building Operations, and Climate; Task 4 - Develop an Approach for Treating Economic Considerations; Task 5 - Develop an Approach for Treating Energy Sources; Task 6 - Collect Energy-Use Data; Task 7 - Survey Energy Expert Opinion; Task 8 - Evaluation Procedure Specification and Integration; Task 9 - Phase 1 Report Development; and Task 10 - Phase 1 Review Planning.

  11. A method to obtain correct standard uptake values in Pinnacle treatment planning system for target volume delineation

    PubMed Central

    Salehzahi, Farshid; Tse, Jason; Lee, Jonathan; Selvaraj, Jothybasu

    2016-01-01

    Standardized uptake value (SUV) is an advanced tool for quantitative tumor identification and metabolic target volume delineation (TVD) in diagnostic and therapeutic settings. It is thus important to establish a quality assured process to maintain the traceability of data correctly by positron emission tomography (PET) systems. Patient administration of 18fluoro-deoxy-glucose is increasingly delivered by automated infusion systems (AISs). Whenever AIS is used, its accuracy and traceability measurement need verification. In addition, it was observed that the unreproducible SUV displayed in PET and the treatment planning system (TPS) may cause grave concerns for radiation oncologists for TVD. This concern may complicate the correlation of TVD on PET and TPS and their clinical reporting. The SUV traceability was established from the PET system to AIS. Its accuracy was verified by cross-referencing to the reference dose calibrator traceable to a primary standard. The SUV values were converted in TPS using the in-house “clinical tool” to be identical as in PET, to allow radiation oncologists to use SUV confidently. The outcome of this study enables the clinical groups to rely on the correct SUV values displayed on the TPS and to improve the quality of care for patients in clinical procedures. PMID:28144116

  12. Maryland National Capital Park and Planning Commission, Shady Grove Solar Office Building. Volume 1. Final technical report

    SciTech Connect

    Not Available

    1982-10-01

    The Shady Grove Solar Office Building is located in Gaithersburg, Maryland, a suburb of Washington, DC. The 3500 square foot structure was designed from the ground up with solar energy as a primary consideration, incorporating both active and passive solar energy collection and storage. The active solar system is designed for heating only. It was determined in the initial design stage that the extra cost of heat exchangers, special piping and pumps would not be justified for DHW considering the small amount of hot water demand in the office. Solar energy is collected by 1500 ft/sup 2/ of KTA tubular solar collectors, stored in a 3000 gallon steel tank, and distributed throughout the building by three water to air heat exchangers in three air handlers. One additional fan coil unit is used for demonstration purposes in the lobby area. The passive system consists of 340 square feet of double glazed windows, oriented true south. This volume includes a narrative description of the building and solar energy system, specifications for the solar energy equipment, acceptance test plans, and photos of the completed project.

  13. Planning magnetic resonance imaging for prostate cancer intensity-modulated radiation therapy: Impact on target volumes, radiotherapy dose and androgen deprivation administration.

    PubMed

    Horsley, Patrick J; Aherne, Noel J; Edwards, Grace V; Benjamin, Linus C; Wilcox, Shea W; McLachlan, Craig S; Assareh, Hassan; Welshman, Richard; McKay, Michael J; Shakespeare, Thomas P

    2015-03-01

    Magnetic resonance imaging (MRI) scans are increasingly utilized for radiotherapy planning to contour the primary tumors of patients undergoing intensity-modulated radiation therapy (IMRT). These scans may also demonstrate cancer extent and may affect the treatment plan. We assessed the impact of planning MRI detection of extracapsular extension, seminal vesicle invasion, or adjacent organ invasion on the staging, target volume delineation, doses, and hormonal therapy of patients with prostate cancer undergoing IMRT. The records of 509 consecutive patients with planning MRI scans being treated with IMRT for prostate cancer between January 2010 and July 2012 were retrospectively reviewed. Tumor staging and treatment plans before and after MRI were compared. Of the 509 patients, 103 (20%) were upstaged and 44 (9%) were migrated to a higher risk category as a result of findings at MRI. In 94 of 509 patients (18%), the MRI findings altered management. Ninety-four of 509 patients (18%) had a change to their clinical target volume (CTV) or treatment technique, and in 41 of 509 patients (8%) the duration of hormone therapy was changed because of MRI findings. The use of radiotherapy planning MRI altered CTV design, dose and/or duration of androgen deprivation in 18% of patients in this large, single institution series of men planned for dose-escalated prostate IMRT. This has substantial implications for radiotherapy target volumes and doses, as well as duration of androgen deprivation. Further research is required to investigate whether newer MRI techniques can simultaneously fulfill staging and radiotherapy contouring roles. © 2014 Wiley Publishing Asia Pty Ltd.

  14. Adapting and Testing Business Management Development Programs for Educational Administrators. Volume 5 of 6 Volumes. Appendix I-Planning Document: North Carolina LEA, Laurinburg-Scotland. Final Report.

    ERIC Educational Resources Information Center

    Klawuhn, Raymond E.; Basso, Alexander J.

    This document is comprised of an appendix that provides a portion of the materials utilized in the project to test the feasibility of adapting business management practices to educational institutions. Included is the educational planning process document for one of the eight participating management teams. The planning process document states the…

  15. Quantification of Trade-Off Between Parotid Gland Sparing and Planning Target Volume Underdosages in Clinically Node-Negative Head-and-Neck Intensity-Modulated Radiotherapy

    SciTech Connect

    Kruijf, Wilhelmus de . E-mail: kruijf.de.w@bvi.nl; Heijmen, Ben; Levendag, Peter C.

    2007-05-01

    Purpose: To quantify the trade-off between parotid gland sparing and planning target volume (PTV) underdosages for head-and-neck intensity-modulated radiotherapy. Methods and Materials: A planning study was performed for 4 patients with either soft palate or tonsil tumors treated with external radiotherapy up to 46 Gy. The trade-off between underdosages in the PTV and sparing of the parotid glands was investigated by systematically varying the optimization objectives for the inverse planning. A new way of presenting dose-volume information allows easy detection of small PTV subvolumes with underdosages that cannot be assessed in conventional cumulative dose-volume histograms. A simple radiobiological model to estimate the control probability for an electively irradiated neck level was developed. Results: The average dose to the parotid glands can decrease by >10 Gy by allowing the PTV to be underdosed in such a way that the radiobiological model predicts a decrease in subclinical disease control probability of (typically) 1% to a few percent. Conclusion: The trade-off between parotid gland sparing and underdosages in the PTV has been quantified by the use of an alternative method to present dose-volume information and by the use of a radiobiological model to predict subclinical disease control probability.

  16. Inverse-planned, dynamic, multi-beam, intensity-modulated radiation therapy (IMRT): a promising technique when target volume is the left breast and internal mammary lymph nodes.

    PubMed

    Popescu, Carmen C; Olivotto, Ivo; Patenaude, Veronica; Wai, Elaine; Beckham, Wayne A

    2006-01-01

    The purpose of this study was to determine the optimum beam number and orientation for inverse-planned, dynamic intensity-modulated radiation therapy (IMRT) for treatment of left-sided breast cancer and internal mammary nodes (IMNs) to improve target coverage while reducing cardiac and ipsilateral lung irradiation. Computed tomography (CT) data was used from 5 patients with left-sided breast cancer in whom the heart was close to the chest wall. The planning target volume (PTV) was the full breast plus ipsilateral IMNs. Two geometric beam arrangements were investigated, 240 degrees and 190 degrees sector angles, and the number of beams was increased from 7 to 9 to 11. Dose comparison metrics included: PTV homogeneity and conformity indices (HI, CI), heart V30, left lung V20, and mean doses to surrounding structures. To assess clinical application, the IMRT plans with 11 beams equally spaced in a 190 degrees sector angle were compared to conventional plans. Treatment times were modeled. The 190 degrees IMRT plans improved PTV HI and CI and reduced mean dose to the heart, lungs, contralateral breast, and total healthy tissue (all p < 0.05) compared to a 240 degrees sector angle. The 11-beam plan significantly improved PTV HI and CI, heart V30, left lung V20, and healthy tissue V5 compared to a 7-beam plan (all p < 0.05). The 11-beam plan reduced heart V30 and left lung V20 (p < 0.05) without compromising PTV coverage, compared to a 9-beam plan. Compared to a conventional plan, the IMRT class solution significantly improved PTV HI and CI (both p < 0.01), heart V30 (p = 0.01), and marginally reduced left lung V20 (p = 0.07) but increased contralateral breast and lung mean dose (p < 0.001) and healthy tissue V5 (p < 0.001). An 11-beam 190 degrees sector angle IMRT technique as a class solution is clinically feasible.

  17. Comprehensive Planning for an Education System. Report #2, Definition Summary. Appendices, Volume 1. Fort Lincoln New Town Education System.

    ERIC Educational Resources Information Center

    General Learning Corp., Washington, DC.

    This appendices reports on the definition phase activities of planning for the Fort Lincoln New Town education system. Included are complete reports on the community resources survey and the demographic survey. The General Learning Corporation planning documents are presented in tabular format. A community planning timetable is outlined and the…

  18. Report to the Government of Jamaica coal feasibility study and financing plan. Phase 2, volume 2, appendix A. Associated environmental impact assessment. Export trade information

    SciTech Connect

    1983-09-01

    The report shows the results of a study conducted to determine the feasibility of an oil-to-coal conversion program for Jamaica`s major energy consuming facilities. This report, which is Phase II of the study, prepares the specifications for the principal equipment and develops financing and implementation plans for the project. This is Volume 2 and it contains the Appendix-Associated Environmental Impact Assessment.

  19. Saugus River and Tributaries, Lynn Malden, Revere and Saugus, Massachusetts. Flood Damage Reduction. Volume 6. Appendix I. Planning Correspondence: Lynn, Malden, Revere, Saugus, Interest Groups, and News Articles

    DTIC Science & Technology

    1989-06-01

    Feasibility Report - Draft Environmental Impact Statement/Report Water Resources Investigation Saugus River and Tributaries, Lynn, Maiden , Revere and...Saugus, Massachusetts Flood Damage Reduction Volume 6 Appendix I - Planning Correspondence Lynn, Maiden , Revere, Saugus, 11NW 4* Interest Groups, and...Commission 92 Lake View Avenue Lynn, MA 01901 Ms. Linda Villiams 33 Sweetser Terrace Lynn. MA 01901 E-IOa DEPARTMENT OF THE ARMY NEW ENGLAND DIVISION

  20. Investigation on the role of integrated PET/MRI for target volume definition and radiotherapy planning in patients with high grade glioma.

    PubMed

    Navarria, Pierina; Reggiori, Giacomo; Pessina, Federico; Ascolese, Anna Maria; Tomatis, Stefano; Mancosu, Pietro; Lobefalo, Francesca; Clerici, Elena; Lopci, Egesta; Bizzi, Alberto; Grimaldi, Marco; Chiti, Arturo; Simonelli, Matteo; Santoro, Armando; Bello, Lorenzo; Scorsetti, Marta

    2014-09-01

    To evaluate the impact of fluid-attenuated-inversion-recovery MRI (FLAIR/MRI) and Carbon-11-labeled-methionine PET (11C-MET-PET) on high grade glioma (HGG) tumor volume delineation for radiotherapy planning. Sixty-nine patients with HGG were evaluated. The clinical target volumes (CTV1, generated by adding a 10mm margin to FLAIRMRI area, CTV2 by adding a 20mm margin to enhanced T1MRI) and biological target volume (BTV) were delineated on pre-operative MRI images and 11CMETPET respectively. The overlap between CTV1 and CTV2 showed a low correlation between the two volumes with CTV1 not always fully included into the CTV2. In all cases the whole BTV was included into the CTV1, while in 35/69 patients (50%) part of BTV was outside the CTV2 despite larger margins were added. In all cases recurrences were within the CTV1 volume and in 19/38 (50%) partially outside the CTV2. In all patients relapse corresponded to the BTV area. Our data suggest that the target volume definition using FLAIR-MRI is more adequate compared to enhanced T1MRI. 11C-METPET uptake could help identify microscopic residual areas. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  1. Multi-scenario based robust intensity-modulated proton therapy (IMPT) plans can account for set-up errors more effectively in terms of normal tissue sparing than planning target volume (PTV) based intensity-modulated photon plans in the head and neck region.

    PubMed

    Stuschke, Martin; Kaiser, Andreas; Abu Jawad, Jehad; Pöttgen, Christoph; Levegrün, Sabine; Farr, Jonathan

    2013-06-18

    In a previous report, we compared the conformity of robust intensity-modulated proton therapy (IMPT) plans with that of helical tomotherapy plans for re-irradiations of head and neck carcinomas using a fixed set-up error of 2 mm. Here, we varied the maximum set-up errors between 0 and 5 mm and compared the robust IMPT-plans with planning target volume (PTV) based intensity-modulated photon therapy (IMRT). Seven patients were treated with a PTV-based tomotherapy plan. Set-up margins of 0, 2, and 5 mm were subtracted from the PTV to generate target volumes (TV) TV(0mm), TV(2mm), and TV(5mm), for which robust IMPT-plans were created assuming range uncertainties of ±3.5% and using worst case optimization assuming set-up errors of 0, 2, and 5 mm, respectively. Robust optimization makes use of the feature that set-up errors in beam direction alone do not affect the distal and proximal margin for that beam. With increasing set-up errors, the body volumes that were exposed to a selected minimum dose level between 20% and 95% of the prescribed dose decreased. In IMPT-plans with 0 mm set-up error, the exposed body volumes were on average 6.2% ± 0.9% larger than for IMPT-plans with 2 mm set-up error, independent of the considered dose level (p < 0.0001, F-test). In IMPT-plans accounting for 5 mm set-up error, the exposed body volumes were by 11.9% ± 0.8% smaller than for IMPT-plans with 2 mm set-up error at a fixed minimum dose (p < 0.0001, F-test). This set-up error dependence of the normal tissue exposure around the TV in robust IMPT-plans corresponding to the same IMRT-plan led to a decrease in the mean dose to the temporal lobes and the cerebellum, and in the D2% of the brain stem or spinal cord with increasing set-up errors considered during robust IMPT-planning. For recurrent head and neck cancer, robust IMPT-plan optimization led to a decrease in normal tissue exposure with increasing set-up error for target volumes corresponding to the same PTV.

  2. Dosimetric accuracy of a treatment planning system for actively scanned proton beams and small target volumes: Monte Carlo and experimental validation

    NASA Astrophysics Data System (ADS)

    Magro, G.; Molinelli, S.; Mairani, A.; Mirandola, A.; Panizza, D.; Russo, S.; Ferrari, A.; Valvo, F.; Fossati, P.; Ciocca, M.

    2015-09-01

    This study was performed to evaluate the accuracy of a commercial treatment planning system (TPS), in optimising proton pencil beam dose distributions for small targets of different sizes (5-30 mm side) located at increasing depths in water. The TPS analytical algorithm was benchmarked against experimental data and the FLUKA Monte Carlo (MC) code, previously validated for the selected beam-line. We tested the Siemens syngo® TPS plan optimisation module for water cubes fixing the configurable parameters at clinical standards, with homogeneous target coverage to a 2 Gy (RBE) dose prescription as unique goal. Plans were delivered and the dose at each volume centre was measured in water with a calibrated PTW Advanced Markus® chamber. An EBT3® film was also positioned at the phantom entrance window for the acquisition of 2D dose maps. Discrepancies between TPS calculated and MC simulated values were mainly due to the different lateral spread modeling and resulted in being related to the field-to-spot size ratio. The accuracy of the TPS was proved to be clinically acceptable in all cases but very small and shallow volumes. In this contest, the use of MC to validate TPS results proved to be a reliable procedure for pre-treatment plan verification.

  3. Financial constraints in capacity planning: a national utility regulatory model (NUREG). Volume III of III: software description. Final report

    SciTech Connect

    1981-10-29

    This volume is the software description for the National Utility Regulatory Model (NUREG). This is the third of three volumes provided by ICF under contract number DEAC-01-79EI-10579. These three volumes are: a manual describing the NUREG methodology; a users guide; and a description of the software. This manual describes the software which has been developed for NUREG. This includes a listing of the source modules. All computer code has been written in FORTRAN.

  4. SU-E-J-88: Margin Reduction of Level II/III Planning Target Volume for Image-Guided Simultaneous Integrated Boost Head-And-Neck Treatment

    SciTech Connect

    Can, S; Neylon, J; Qi, S; Santhanam, A; Low, D

    2014-06-01

    Purpose: To investigate the feasibility of improved normal tissue sparing for head-and-neck (H'N) image-guided radiotherapy (IGRT) by employing tighter CTV-to-PTV margins for target level II/III though a GPU-based deformable image registration and dose accumulation framework. Methods: Ten H'N simultaneous integrated boost cases treated on TomoTherapy were retrospectively analyzed. Weekly kVCT scans in addition to daily MVCT scans were acquired for each patient. Reduced margin plans were generated with 0- mm margin for level II and III PTV (while 3-5 mm margin for PTV1) and compared with the standard margin plan using 3-5mm margin to all CTV1-3 (reference plan). An in-house developed GPU-based 3D image deformation tool was used to register and deform the weekly KVCTs with the planning CT and determine the delivered mean/minimum/maximum dose, dose volume histograms (DVHs), etc. Results: Compared with the reference plans, the averaged cord maximum, the right and left parotid doses reduced by 22.7 %, 16.5 %, and 9 % respectively in the reduced margin plans. The V95 for PTV2 and PTV3 were found within 2 and 5% between the reference and tighter margin plans. For the reduced margin plans, the averaged cumulative mean doses were consistent with the planned dose for PTV1, PTV2 and PTV3 within 1.5%, 1.7% and 1.4%. Similar dose variations of the delivered dose were seen for the reference and tighter margin plans. The delivered maximum and mean doses for the cord were 3.55 % and 2.37% higher than the planned doses; a 5 % higher cumulative mean dose for the parotids was also observed for the delivered dose than the planned doses in both plans. Conclusion: By imposing tighter CTV-to-PTV margins for level II and III targets for H'N irradiation, acceptable cumulative doses were achievable when coupled with weekly kVCT guidance while improving normal structure sparing.

  5. Adapting and Testing Business Management Development Programs for Educational Administrators. Volume 3 of 6 Volumes. Appendix E-Planning Document: Maryland LEA, Prince George's Co., Appendix F-Planning Document: North Carolina SEA, Executive Staff. Final Report.

    ERIC Educational Resources Information Center

    Klawuhn, Raymond E.; Basso, Alexander J.

    This document is comprised of two appendixes that provide a portion of the materials utilized in the project to test the feasibility of adapting business management practices to educational institutions. Included are the educational planning process documents for two of the eight participating management teams. Each planning process document…

  6. Adapting and Testing Business Management Development Programs for Educational Administrators. Volume 4 of 6 Volumes. Appendix G-Planning Document: North Carolina SEA, Program Services. Appendix H-Planning Document: North Carolina LEA, Cabarrus County. Final Report.

    ERIC Educational Resources Information Center

    Klawuhn, Raymond E.; Basso, Alexander J.

    This document is comprised of two appendixes that provide a portion of the materials utilized in the project to test the feasibility of adapting business management practices to educational institutions. Included are the educational planning process documents for two of the eight participating management teams. Each planning process document…

  7. A new brain positron emission tomography scanner with semiconductor detectors for target volume delineation and radiotherapy treatment planning in patients with nasopharyngeal carcinoma.

    PubMed

    Katoh, Norio; Yasuda, Koichi; Shiga, Tohru; Hasegawa, Masakazu; Onimaru, Rikiya; Shimizu, Shinichi; Bengua, Gerard; Ishikawa, Masayori; Tamaki, Nagara; Shirato, Hiroki

    2012-03-15

    We compared two treatment planning methods for stereotactic boost for treating nasopharyngeal carcinoma (NPC): the use of conventional whole-body bismuth germanate (BGO) scintillator positron emission tomography (PET(CONV)WB) versus the new brain (BR) PET system using semiconductor detectors (PET(NEW)BR). Twelve patients with NPC were enrolled in this study. [(18)F]Fluorodeoxyglucose-PET images were acquired using both the PET(NEW)BR and the PET(CONV)WB system on the same day. Computed tomography (CT) and two PET data sets were transferred to a treatment planning system, and the PET(CONV)WB and PET(NEW)BR images were coregistered with the same set of CT images. Window width and level values for all PET images were fixed at 3000 and 300, respectively. The gross tumor volume (GTV) was visually delineated on PET images by using either PET(CONV)WB (GTV(CONV)) images or PET(NEW)BR (GTV(NEW)) images. Assuming a stereotactic radiotherapy boost of 7 ports, the prescribed dose delivered to 95% of the planning target volume (PTV) was set to 2000 cGy in 4 fractions. The average absolute volume (±standard deviation [SD]) of GTV(NEW) was 15.7 ml (±9.9) ml, and that of GTV(CONV) was 34.0 (±20.5) ml. The average GTV(NEW) was significantly smaller than that of GTV(CONV) (p = 0.0006). There was no statistically significant difference between the maximum dose (p = 0.0585) and the mean dose (p = 0.2748) of PTV. The radiotherapy treatment plan based on the new gross tumor volume (PLAN(NEW)) significantly reduced maximum doses to the cerebrum and cerebellum (p = 0.0418) and to brain stem (p = 0.0041). Results of the present study suggest that the new brain PET system using semiconductor detectors can provide more accurate tumor delineation than the conventional whole-body BGO PET system and may be an important tool for functional and molecular radiotherapy treatment planning. Copyright © 2012 Elsevier Inc. All rights reserved.

  8. A New Brain Positron Emission Tomography Scanner With Semiconductor Detectors for Target Volume Delineation and Radiotherapy Treatment Planning in Patients With Nasopharyngeal Carcinoma

    SciTech Connect

    Katoh, Norio; Yasuda, Koichi; Shiga, Tohru; Hasegawa, Masakazu; Onimaru, Rikiya; Shimizu, Shinichi; Bengua, Gerard; Ishikawa, Masayori; Tamaki, Nagara; Shirato, Hiroki

    2012-03-15

    Purpose: We compared two treatment planning methods for stereotactic boost for treating nasopharyngeal carcinoma (NPC): the use of conventional whole-body bismuth germanate (BGO) scintillator positron emission tomography (PET{sub CONV}WB) versus the new brain (BR) PET system using semiconductor detectors (PET{sub NEW}BR). Methods and Materials: Twelve patients with NPC were enrolled in this study. [{sup 18}F]Fluorodeoxyglucose-PET images were acquired using both the PET{sub NEW}BR and the PET{sub CONV}WB system on the same day. Computed tomography (CT) and two PET data sets were transferred to a treatment planning system, and the PET{sub CONV}WB and PET{sub NEW}BR images were coregistered with the same set of CT images. Window width and level values for all PET images were fixed at 3000 and 300, respectively. The gross tumor volume (GTV) was visually delineated on PET images by using either PET{sub CONV}WB (GTV{sub CONV}) images or PET{sub NEW}BR (GTV{sub NEW}) images. Assuming a stereotactic radiotherapy boost of 7 ports, the prescribed dose delivered to 95% of the planning target volume (PTV) was set to 2000 cGy in 4 fractions. Results: The average absolute volume ({+-}standard deviation [SD]) of GTV{sub NEW} was 15.7 ml ({+-}9.9) ml, and that of GTV{sub CONV} was 34.0 ({+-}20.5) ml. The average GTV{sub NEW} was significantly smaller than that of GTV{sub CONV} (p = 0.0006). There was no statistically significant difference between the maximum dose (p = 0.0585) and the mean dose (p = 0.2748) of PTV. The radiotherapy treatment plan based on the new gross tumor volume (PLAN{sub NEW}) significantly reduced maximum doses to the cerebrum and cerebellum (p = 0.0418) and to brain stem (p = 0.0041). Conclusion: Results of the present study suggest that the new brain PET system using semiconductor detectors can provide more accurate tumor delineation than the conventional whole-body BGO PET system and may be an important tool for functional and molecular radiotherapy

  9. Site plan safety submission for sampling, monitoring and decontamination of mustard agent, South Plant, Rocky Mountain Arsenal. Volume 1

    SciTech Connect

    Not Available

    1988-10-01

    The scope of this site plan safety submission (SPSS) includes: (1) Sampling plan to determine if H is a contaminant in Equipment and piping used in the 1970's for the H DEMIL program; (2) Monitoring plan for personnel involved in the sampling effort; and (3) Decon plan for personnel, equipment, and piping should contamination be identified. Additional sections and appendices include: (1) Historical use of Bld 637 and Bld 538; (2) Chemical information on H, HD, and HT; (3) Safety requirements; (4) Medical requirements and first aid procedures; (5) Piping drawings; and (6) RMA SOP's for sampling, monitoring, and decon.

  10. Site plan safety submission for sampling, monitoring, decontamination of GB agent - north plant Rocky Mountain Arsenal. Volume 1

    SciTech Connect

    Not Available

    1988-10-01

    The scope of this site plan safety submission (SPSS), includes: sampling plan to determine if GB is a contaminant in equipment and piping used in the production and demil processes; monitoring plan for personnel involved in the sampling effort; decon plan for personnel, equipment, and piping should contamination be identified. Additional sections and appendices include: historical use of bldg 1501, 1503, 1504, 1506, 1601, 1602, 1603, 1606; chemical information on GB; safety requirements; medical requirements and first aid procedures; piping drawings; rma sop's for sampling, monitoring, and decon.

  11. Prostate Planning Treatment Volume Margin Calculation Based on the ExacTrac X-Ray 6D Image-Guided System: Margins for Various Clinical Implementations

    SciTech Connect

    Alonso-Arrizabalaga, Sara Brualla Gonzalez, Luis; Rosello Ferrando, Juan V.; Pastor Peidro, Jorge; Lopez Torrecilla, Jose; Planes Meseguer, Domingo; Garcia Hernandez, Trinidad

    2007-11-01

    Purpose: To assess the prostate motion from day-to-day setup, as well as during irradiation time, to calculate planning target volume (PTV) margins. PTV margins differ depending on the clinical implementation of an image-guided system. Three cases were considered in this study: daily bony anatomy match, center of gravity of the implanted marker seeds calculated with a limited number of imaged days, and daily online correction based on implanted marker seeds. Methods and Materials: A cohort of 30 nonrandomized patients and 1,330 pairs of stereoscopic kV images have been used to determine the prostate movement. The commercial image guided positioning tool employed was ExacTrac X-Ray 6D (BrainLAB AG, Feldkirchen, Germany). Results: Planning target volume margins such that a minimum of 95% of the prescribed dose covers the clinical target volume for 90% of the population are presented. PTV margins based on daily bony anatomy match, including intrafraction correction, would be 11.5, 13.5, and 4.5 mm in the anterior-posterior, superior-inferior, and right-left directions, respectively. This margin can be further reduced to 8.1, 8.6, and 4.8 mm (including intrafraction motion) if implanted marker seeds are used. Finally, daily on line correction based on marker seeds would result in the smallest of the studied margins: 4.7, 6.2, and 1.9 mm. Conclusion: Planning target volume margins are dependent on the local clinical use of the image-guided RT system available in any radiotherapy department.

  12. Program, Planning, Budgeting Systems for Educators. Volume II: A Case Problem. Final Report. Leadership Series No. 19.

    ERIC Educational Resources Information Center

    McGivney, Joseph H.; Nelson, William C.

    This case problem is designed for use by planning, budgeting, or administrative personnel in state or regional vocational educational organizations. The problem involves planning, programming, and budgeting which is best accomplished in small group settings. Each small group should ideally consist of persons with a variety of duties and…

  13. Department of State Strategic Planning Workshop II. Center for Strategic Leadership Issue Paper, Volume 01-02

    DTIC Science & Technology

    2002-04-01

    This workshop was organized to expose State Department employees to the Army’s strategic planning process and how it is integrated into the...professional military education, and military strategic planning concepts and methodologies. State Department participants devoted the second day to

  14. Techniques of Institutional Research and Long Range Planning for Colleges and Universities, Volume I: Enrollment Projections, Induced Course Load Matrix, Faculty Planning.

    ERIC Educational Resources Information Center

    Pickett, William L.

    The models presented in this volume were designed to fit the typical situation. Each user of these techniques will have to modify them to ensure their applicability to his institution. Although the material exploits the capabilities of the PLANTRAN system, computer processing is not required for use of the models. The techniques dealt with here…

  15. Configuration evaluation and criteria plan. Volume 1: System trades study and design methodology plan (preliminary). Space Transportation Main Engine (STME) configuration study

    NASA Technical Reports Server (NTRS)

    Bair, E. K.

    1986-01-01

    The System Trades Study and Design Methodology Plan is used to conduct trade studies to define the combination of Space Shuttle Main Engine features that will optimize candidate engine configurations. This is accomplished by using vehicle sensitivities and engine parametric data to establish engine chamber pressure and area ratio design points for candidate engine configurations. Engineering analyses are to be conducted to refine and optimize the candidate configurations at their design points. The optimized engine data and characteristics are then evaluated and compared against other candidates being considered. The Evaluation Criteria Plan is then used to compare and rank the optimized engine configurations on the basis of cost.

  16. Air Force Global Weather Central System Architecture Study. Final System/Subsystem Summary Report. Volume 6. Aerospace Ground Equipment Plan

    DTIC Science & Technology

    1976-03-01

    1, 2, and 3) Volume 3 - Classified Requirements Topics (Secret) Volume 4 - Systems Analysis and Trade Studies Volume 5 - System Description ...General 18 3.1.1 End Item Description and Types of Functions 18 3.1.2 Factors Affecting Operating AGE 19 3.2 Operational Complex Operating Functions... Description of System (Maintenance Aspects) . . . 54 3.1.2 Development of Maintenance Complex 57 1v ■MML ""’:"irfcMiirMiiii i k ■ ■ ■ ’ wnwmf

  17. Financial constraints in capacity planning: a national utility regulatory model (NUREG). Volume II of III: user's guide. Final report

    SciTech Connect

    Not Available

    1981-10-29

    This volume is a User's Guide to the National Utility Regulatory Model (NUREG) and its implementation of the National Coal Model. This is the second of three volumes provided by ICF under contract number DEAC-01-79EI-10579. These three volumes are: a manual describing the NUREG methodology; a users guide; and a description of the software. This manual provides a brief introduction to the National Utility Regulation Model, describes the various programs that comprise the National Utility Regulatory Model, gives sample input files, and provides information needed to run the model.

  18. Financial constraints in capacity planning: a national utility regulatory model (NUREG). Volume I of III: methodology. Final report

    SciTech Connect

    Not Available

    1981-10-29

    This report develops and demonstrates the methodology for the National Utility Regulatory (NUREG) Model developed under contract number DEAC-01-79EI-10579. It is accompanied by two supporting volumes. Volume II is a user's guide for operation of the NUREG software. This includes description of the flow of software and data, as well as the formats of all user data files. Finally, Volume III is a software description guide. It briefly describes, and gives a listing of, each program used in NUREG.

  19. Evaluation of sampling plans for in-service inspection of steam generator tubes. Volume 2, Comprehensive analytical and Monte Carlo simulation results for several sampling plans

    SciTech Connect

    Kurtz, R.J.; Heasler, P.G.; Baird, D.B.

    1994-02-01

    This report summarizes the results of three previous studies to evaluate and compare the effectiveness of sampling plans for steam generator tube inspections. An analytical evaluation and Monte Carlo simulation techniques were the methods used to evaluate sampling plan performance. To test the performance of candidate sampling plans under a variety of conditions, ranges of inspection system reliability were considered along with different distributions of tube degradation. Results from the eddy current reliability studies performed with the retired-from-service Surry 2A steam generator were utilized to guide the selection of appropriate probability of detection and flaw sizing models for use in the analysis. Different distributions of tube degradation were selected to span the range of conditions that might exist in operating steam generators. The principal means of evaluating sampling performance was to determine the effectiveness of the sampling plan for detecting and plugging defective tubes. A summary of key results from the eddy current reliability studies is presented. The analytical and Monte Carlo simulation analyses are discussed along with a synopsis of key results and conclusions.

  20. Inverse-planned, dynamic, multi-beam, intensity-modulated radiation therapy (IMRT): A promising technique when target volume is the left breast and internal mammary lymph nodes

    SciTech Connect

    Popescu, Carmen C. . E-mail: cpopescu@bccancer.bc.ca; Olivotto, Ivo; Patenaude, Veronica; Wai, Elaine; Beckham, Wayne A.

    2006-01-01

    The purpose of this study was to determine the optimum beam number and orientation for inverse-planned, dynamic intensity-modulated radiation therapy (IMRT) for treatment of left-sided breast cancer and internal mammary nodes (IMNs) to improve target coverage while reducing cardiac and ipsilateral lung irradiation. Computed tomography (CT) data was used from 5 patients with left-sided breast cancer in whom the heart was close to the chest wall. The planning target volume (PTV) was the full breast plus ipsilateral IMNs. Two geometric beam arrangements were investigated, 240{sup o} and 190{sup o} sector angles, and the number of beams was increased from 7 to 9 to 11. Dose comparison metrics included: PTV homogeneity and conformity indices (HI, CI), heart V30, left lung V20, and mean doses to surrounding structures. To assess clinical application, the IMRT plans with 11 beams equally spaced in a 190{sup o} sector angle were compared to conventional plans. Treatment times were modeled. The 190{sup o} IMRT plans improved PTV HI and CI and reduced mean dose to the heart, lungs, contralateral breast, and total healthy tissue (all p < 0.05) compared to a 240{sup o} sector angle. The 11-beam plan significantly improved PTV HI and CI, heart V30, left lung V20, and healthy tissue V5 compared to a 7-beam plan (all p < 0.05). The 11-beam plan reduced heart V30 and left lung V20 (p < 0.05) without compromising PTV coverage, compared to a 9-beam plan. Compared to a conventional plan, the IMRT class solution significantly improved PTV HI and CI (both p < 0.01), heart V30 (p = 0.01), and marginally reduced left lung V20 (p = 0.07) but increased contralateral breast and lung mean dose (p < 0.001) and healthy tissue V5 (p < 0.001). An 11-beam 190{sup o} sector angle IMRT technique as a class solution is clinically feasible.

  1. Comparative evaluation of respiratory-gated and ungated FDG-PET for target volume definition in radiotherapy treatment planning for pancreatic cancer.

    PubMed

    Kishi, Takahiro; Matsuo, Yukinori; Nakamura, Akira; Nakamoto, Yuji; Itasaka, Satoshi; Mizowaki, Takashi; Togashi, Kaori; Hiraoka, Masahiro

    2016-08-01

    The purpose of this study was to evaluate the usefulness of respiratory-gated positron emission tomography (4D-PET) in pancreatic cancer radiotherapy treatment planning (RTTP). Fourteen patients with 18F-fluorodeoxyglucose (FDG)-avid pancreatic tumours were evaluated between December 2013 and March 2015. Two sets of volumes were contoured for the pancreatic tumour of each patient. The biological target volume in three-dimensional RTTP (BTV3D) was contoured using conventional respiratory un-gated PET. The BTV3D was then expanded using population-based margins to generate a series of internal target volume 3D (ITV3D) values. The ITV 4D (ITV4D) was contoured using 4D-PET. Each of the five phases of 4D-PET was used for 4D contouring, and the ITV4D was constructed by summing the volumes defined on the five individual 4D-PET images. The relative volumes and normalized volumetric overlap were computed between ITV3D and ITV4D. On average, the FDG-avid tumour volumes were 1.6 (range: 0.8-2.3) fold greater in the ITV4D than in the BTV3D. On average, the ITV3D values were 2.0 (range: 1.1-3.4) fold larger than the corresponding ITV4D values. The ITV generated from 4D-PET can be used to improve the accuracy or reduce normal tissue irradiation compared with conventional un-gated PET-based ITV. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  2. Power Extension Package (PEP) system definition extension, orbital service module systems analysis study. Volume 10: PEP project plan

    NASA Technical Reports Server (NTRS)

    1979-01-01

    Contents: project plan summary; project and mission objectives; related studies and technology support activities; technical summary; management; procurement approach; project definition items and schedule; resources; management review; controlled items; and safety, reliability, and quality assurance.

  3. Preliminary analysis of an integrated logistics system for OSSA payloads. Volume 3: OSSA integrated logistics support planning document

    NASA Technical Reports Server (NTRS)

    Palguta, T.; Bradley, W.; Stockton, T.

    1988-01-01

    Guidance in preparing and updating an integrated logistics support plan (ILSP) is given. Clear, concise, and detailed instructions are provided on the preparation and content of an ILSP in order to ensure a quality document that reflects total program requirements.

  4. Oak Ridge National Laboratory Corrective Action Plan in response to Tiger Team assessment. Volume 2, Revision 5

    SciTech Connect

    Kuliasha, Michael A.

    1991-08-23

    This report presents a complete response to the Tiger Team assessment that was conducted to Oak Ridge National Laboratory (ORNL) and at the US Department of Energy (DOE) Oak Ridge Operations Office (ORO) from October 2, 1990, through November 30, 1990. The action plans have undergone both a discipline review and a cross-cutting review with respect to root cause. In addition, the action plans have been integrated with initiatives being pursued across Martin Marietta Energy Systems, Inc., in response to Tiger Team findings at other DOE facilities operated by Energy Systems. The root cause section is complete and describes how ORNL intends to address the root cause of the findings identified during the assessment. This report is concerned with reactors safety and health findings, responses, and planned actions. Specific areas include: organization and administration; quality verification; operations; maintenance; training and certification; auxiliary systems; emergency preparedness; technical support; nuclear criticality safety; security/safety interface; experimental activities; site/facility safety review; radiological protection; personnel protection; fire protection; management findings, responses, and planned actions; self-assessment findings, responses, and planned actions; and summary of planned actions, schedules, and costs.

  5. U.S. Department of Energy Space and Defense Power Systems Program Ten-Year Strategic Plan, Volume 1 and Volume 2

    SciTech Connect

    Dwight, Carla

    2013-06-01

    The Department of Energy's Space and Defense Power Systems program provides a unique capability for supplying power systems that function in remote or hostile environments. This capability has been functioning since the early 1960s and counts the National Aeronautics and Space Administration as one of its most prominent customers. This enabling technology has assisted the exploration of our solar system including the planets Jupiter, Saturn, Mars, Neptune, and soon Pluto. This capability is one-of-kind in the world in terms of its experience (over five decades), breadth of power systems flown (over two dozen to date) and range of power levels (watts to hundreds of watts). This document describes the various components of that infrastructure, work scope, funding needs, and its strategic plans going forward.

  6. SeaWiFS Technical Report Series. Volume 42; Satellite Primary Productivity Data and Algorithm Development: A Science Plan for Mission to Planet Earth

    NASA Technical Reports Server (NTRS)

    Falkowski, Paul G.; Behrenfeld, Michael J.; Esaias, Wayne E.; Balch, William; Campbell, Janet W.; Iverson, Richard L.; Kiefer, Dale A.; Morel, Andre; Yoder, James A.; Hooker, Stanford B. (Editor); Firestone, Elaine R. (Editor)

    1998-01-01

    Two issues regarding primary productivity, as it pertains to the Sea-viewing Wide Field-of-view Sensor (SeaWiFS) Program and the National Aeronautics and Space Administration (NASA) Mission to Planet Earth (MTPE) are presented in this volume. Chapter 1 describes the development of a science plan for deriving primary production for the world ocean using satellite measurements, by the Ocean Primary Productivity Working Group (OPPWG). Chapter 2 presents discussions by the same group, of algorithm classification, algorithm parameterization and data availability, algorithm testing and validation, and the benefits of a consensus primary productivity algorithm.

  7. Dose/volume-response relations for rectal morbidity using planned and simulated motion-inclusive dose distributions.

    PubMed

    Thor, Maria; Apte, Aditya; Deasy, Joseph O; Karlsdóttir, Àsa; Moiseenko, Vitali; Liu, Mitchell; Muren, Ludvig Paul

    2013-12-01

    Many dose-limiting normal tissues in radiotherapy (RT) display considerable internal motion between fractions over a course of treatment, potentially reducing the appropriateness of using planned dose distributions to predict morbidity. Accounting explicitly for rectal motion could improve the predictive power of modelling rectal morbidity. To test this, we simulated the effect of motion in two cohorts. The included patients (232 and 159 cases) received RT for prostate cancer to 70 and 74 Gy. Motion-inclusive dose distributions were introduced as simulations of random or systematic motion to the planned dose distributions. Six rectal morbidity endpoints were analysed. A probit model using the QUANTEC recommended parameters was also applied to the cohorts. The differences in associations using the planned over the motion-inclusive dose distributions were modest. Statistically significant associations were obtained with four of the endpoints, mainly at high doses (55-70 Gy), using both the planned and the motion-inclusive dose distributions, primarily when simulating random motion. The strongest associations were observed for GI toxicity and rectal bleeding (Rs=0.12-0.21; Rs=0.11-0.20). Applying the probit model, significant associations were found for tenesmus and rectal bleeding (Rs=0.13, p=0.02). Equally strong associations with rectal morbidity were observed at high doses (>55 Gy), for the planned and the simulated dose distributions including in particular random rectal motion. Future studies should explore patient-specific descriptions of rectal motion to achieve improved predictive power. Published by Elsevier Ireland Ltd.

  8. Tank Waste Remediation System fiscal year 1996 multi-year program plan WBS 1.1. Revision 1, Volume 1

    SciTech Connect

    1995-09-01

    The 1995 Hanford Mission Plan specifically addresses the tank waste issue and clarifies the link with other initiatives, such as improving management practices and the Hanford Site Waste Minimization and Pollution Prevention Awareness Program Plan (DOE/RL-91-31). This document captures the results of decision making regarding the application of systems engineering at the Hanford Site, external involvement policy, and site end-state goals. Section 3.5 of the Hanford Mission Plan on Decisions and Directives provides an integrating discussion of the actions of the National Environmental Policy Act (NEPA), and DOE policy, guidance, and decisions associated with binding agreements such as the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement). Two significant components of the Hanford Mission Plan 1994 planning basis are (1) the decisions regarding the disposition of onsite material inventory, and the key programs and interfaces to accomplish this; and (2) the Program Interface Issues section, which identified issues that stretch across program boundaries.

  9. Site Characterization Plan: Yucca Mountain Site, Nevada Research and Development Area, Nevada: Volume 3, Part A: Chapters 6 and 7

    SciTech Connect

    1988-12-01

    This site characterization plan (SCP) has been developed for the candidate repository site at Yucca Mountain in the State of Nevada. The SCP includes a description of the Yucca Mountain site (Chapters 1-5), a conceptual design for the repository (Chapter 6), a description of the packaging to be used for the waste to be emplaced in the repository (Chapter 7), and a description of the planned site characterization activities (Chapter 8). The schedules and milestones presented in Sections 8.3 and 8.5 of the SCP were developed to be consistent with the June 1988 draft Amendment to the DOE`s Mission Plan for the Civilian Radioactive Waste Management Program. The five month delay in the scheduled start of exploratory shaft construction that was announced recently is not reflected in these schedules. 218 figs., 50 tabs.

  10. Site characterization plan: Yucca Mountain Site, Nevada Research and Development Area, Nevada: Volume 1, Part A: Chapters 1 and 2

    SciTech Connect

    1988-12-01

    This site characterization plan (SCP) has been developed for the candidate repository site at Yucca Mountain in the State of Nevada. The SCP includes a description of the Yucca Mountain site (Chapters 1-5), a conceptual design for the repository (Chapter 6), a description of the packaging to be used for the waste to be emplaced in the repository (Chapter 7), and a description of the planned site characterization activities (Chapter 8). The schedules and milestones presented in Sections 8.3 and 8.5 of the SCP were developed to be consistent with the June 1988 draft Amendment to the DOE`s Mission Plan for the Civilian Radioactive Waste Management Program. The five month delay in the scheduled start of exploratory shaft construction that was announced recently is not reflected in these schedules. 750 refs., 123 figs., 42 tabs.

  11. Technique for integrative energy planning in developing nations with illustrative application to Pakistan. (Volumes I and II)

    SciTech Connect

    Ciliano, R.E.

    1985-01-01

    This dissertation focuses on the conceptual definition, development and illustrative application of a new methodology for integrative energy planning in less developed countries (LDCs). The author terms his approach the Integrative Planning Technique (IPT). The IPT provides a direct linkage between sectoral activity levels and targets specified in the overall economic development plan and the energy system physical infrastructure and resource flows upon which they depend. Central concepts within the IPT include (a) the Energy Resource Delivery Network (ERDN), a network representation of the overall energy system from resource extraction through ultimate end-use; and (b) the Resource Coefficient Table (RCT), a computational matrix method which prepares inputs to the ERDN and provides the building block basis for translating policy initiatives relating to new technology penetration, interfuel substitution, and re-directed development targets into corresponding energy requirements associated with policy implementation.

  12. MOX capsule post-irradiation examination. Volume 2: Test plan for 30-GWd/MT burnup fuel

    SciTech Connect

    Morris, R.N.

    1997-12-01

    This test plan is a Level-2 document as defined in the Fissile Materials Disposition Program Light-Water Reactor Mixed-Oxide Fuel Irradiation Test Project Plan. The planned post-irradiation examination (PIE) work to be performed on the mixed uranium and plutonium oxide fuel capsules that have received burnups of approximately 30 GWd/MT is described. The major emphasis of this PIE task will be material interactions, particularly indications of gallium transport and interactions. This PIE will include gamma scanning, ceramography, metallography, pellet radial gallium analysis, and clad gallium analysis. A preliminary PIE report will be generated before all the work is completed so that the progress of the fuel irradiation may be known in a timely manner.

  13. Oak Ridge National Laboratory Corrective Action Plan in response to Tiger Team assessment. Volume 1, Revision 5

    SciTech Connect

    Kuliasha, Michael A.

    1991-08-23

    This report presents a complete response to the Tiger Team assessment that was conducted at Oak Ridge National Laboratory (ORNL) and at the US Department of Energy (DOE) Oak Ridge Operations Office (ORO) from October 22, 1990, through November 30, 1990. The action plans have undergone both a discipline review and a cross-cutting review with respect to root cause. In addition, the action plans have been integrated with initiatives being pursued across Martin Marietta Energy Systems, Inc., in response to Tiger Team findings at other DOE facilities operated by Energy Systems. The root cause section is complete and describes how ORNL intends to address the root causes of the findings identified during the assessment. The action plan has benefited from a complete review by various offices at DOE Headquarters as well as review by the Tiger Team that conducted the assessment to ensure that the described actions are responsive to the observed problems.

  14. Performance-based ratemaking for electric utilities: Review of plans and analysis of economic and resource-planning issues. Volume 2, Appendices

    SciTech Connect

    Comnes, G.A.; Stoft, S.; Greene, N.; Hill, L.J.

    1995-11-01

    This document contains summaries of the electric utilities performance-based rate plans for the following companies: Alabama Power Company; Central Maine Power Company; Consolidated Edison of New York; Mississippi Power Company; New York State Electric and Gas Corporation; Niagara Mohawk Power Corporation; PacifiCorp; Pacific Gas and Electric; Southern California Edison; San Diego Gas & Electric; and Tucson Electric Power. In addition, this document also contains information about LBNL`s Power Index and Incentive Properties of a Hybrid Cap and Long-Run Demand Elasticity.

  15. Program plan for the DOE Office of Fusion Energy First Wall/Blanket/Shield Engineering Technology Program. Volume II. Detailed technical plan. Revision 2

    SciTech Connect

    Not Available

    1982-08-01

    The four sections which comprise Part II describe in detail the technical basis for each of the four Program Elements (PE's) of the FWBS Engineering Technology Program (ETP). Each PE is planned to be executed in a number of phases. The purpose of the DTP's is to delineate detailed near-term research, development, and testing required to establish a FWBS engineering data base. Optimum testing strategies and construction of test facilities where needed are identified. The DTP's are based on guidelines given by Argonne National Laboratory which included the basic programmatic goals and the requirements for the types of tests and test conditions.

  16. The Coordination of Program Planning and Evaluation Systems for Occupational Education. Volume 2: A Targeting System for Occupational Education.

    ERIC Educational Resources Information Center

    Riverside Research Inst., New York, NY.

    The second volume of the final report deals with the targeting system--one of a hierarchy of systems required to support the effective delivery of superior occupational education. It determines that program objectives match student training in occupations, that the best choice of occupations in which to train students has been made, and that the…

  17. Education, Work and Employment--Volume II. Segmented Labour Markets, Workplace Democracy and Educational Planning, Education and Self-Employment.

    ERIC Educational Resources Information Center

    Carnoy, Martin; And Others

    This volume contains three studies covering separate yet complementary aspects of the problem of the relationships between the educational system and the production system as manpower user. The first monograph on the theories of the markets seeks to answer two questions: what can be learned from the work done on the segmentation of the labor…

  18. Entrepreneurship Education for Agriculture. Phase "O" Planning Project Report. Performance Report. Volume II: Bibliography and Storyboard Scripts.

    ERIC Educational Resources Information Center

    Lee and Associates, Starkville, MS.

    Volume 2 of this report is supplementary and contains three bibliographies: (1) Annotated Bibliography on Minority Entrepreneurship in Agriculture; (2) Annotated Bibliography on Entrepreneurship Education in Agriculture; (3) Bibliography on Entrepreneurship. The next section presents three storyboard scripts for instructional videotapes on…

  19. Old hydrofracture facility tanks contents removal action operations plan at the Oak Ridge National Laboratory, Oak Ridge, Tennessee. Volume 1: Text. Volume 2: Checklists and work instructions

    SciTech Connect

    1998-05-01

    This Operations Plan summarizes the operating activities for transferring contents of five low-level (radioactive) liquid waste storage tanks associated with the Old Hydrofracture Facility (OHF) to the Melton Valley Storage Tanks (MVST) for secure storage. The transfer will be accomplished through sluicing and pumping operations which are designed to pump the slurry in a closed circuit system using a sluicing nozzle to resuspend the sludge. Once resuspended, the slurry will be transferred to the MVST. The report documenting the material transfer will be prepared after transfer of the tank materials has been completed. The OBF tanks contain approximately 52,600 gal (199,000 L) of low-level radioactive waste consisting of both sludge and supernatant. This material is residual from the now-abandoned grout injection operations conducted from 1964 to 1980. Total curie content is approximately 30,000 Ci. A sluicing and pumping system has been specifically designed for the OHF tanks contents transfer operations. This system is remotely operated and incorporates a sluicing nozzle and arm (Borehole Miner) originally designed for use in the mining industry. The Borehole Miner is an in-tank device designed to deliver a high pressure jet spray via an extendable nozzle. In addition to removing the waste from the tanks, the use of this equipment will demonstrate applicability for additional underground storage tank cleaning throughout the U.S. Department of Energy complex. Additional components of the complete sluicing and pumping system consist of a high pressure pumping system for transfer to the MVST, a low pressure pumping system for transfer to the recycle tank, a ventilation system for providing negative pressure on tanks, and instrumentation and control systems for remote operation and monitoring.

  20. Performance-based ratemaking for electric utilities: Review of plans and analysis of economic and resource-planning issues. Volume 1

    SciTech Connect

    Comnes, G.A.; Stoft, S.; Greene, N.; Hill, L.J. |

    1995-11-01

    Performance-Based Ratemaking (PBR) is a form of utility regulation that strengthens the financial incentives to lower rates, lower costs, or improve nonprice performance relative traditional regulation, which the authors call cost-of-service, rate-of-return (COS/ROR) regulation. Although the electric utility industry has considerable experience with incentive mechanisms that target specific areas of performance, implementation of mechanisms that cover a comprehensive set of utility costs or services is relatively rare. In recent years, interest in PBR has increased as a result of growing dissatisfaction with COS/ROR and as a result of economic and technological trends that are leading to more competition in certain segments of the electricity industry. In addition, incentive regulation has been used with some success in other public utility industries, most notably telecommunications in the US and telecommunications, energy, and water in the United Kingdom. In this report, the authors analyze comprehensive PBR mechanisms for electric utilities in four ways: (1) they describe different types of PBR mechanisms, (2) they review a sample of actual PBR plans, (3) they consider the interaction of PBR and utility-funded energy efficiency programs, and (4) they examine how PBR interacts with electric utility resource planning and industry restructuring. The report should be of interest to technical staff of utilities and regulatory commissions that are actively considering or designing PBR mechanisms. 16 figs., 17 tabs.

  1. Fully automatic guidance and control for rotorcraft nap-of-the-Earth flight following planned profiles. Volume 1: Real-time piloted simulation

    NASA Technical Reports Server (NTRS)

    Clement, Warren F.; Gorder, Peter J.; Jewell, Wayne F.

    1991-01-01

    Developing a single-pilot, all-weather nap-of-the-earth (NOE) capability requires fully automatic NOE (ANOE) navigation and flight control. Innovative guidance and control concepts are investigated in a four-fold research effort that: (1) organizes the on-board computer-based storage and real-time updating of NOE terrain profiles and obstacles in course-oriented coordinates indexed to the mission flight plan; (2) defines a class of automatic anticipative pursuit guidance algorithms and necessary data preview requirements to follow the vertical, lateral, and longitudinal guidance commands dictated by the updated flight profiles; (3) automates a decision-making process for unexpected obstacle avoidance; and (4) provides several rapid response maneuvers. Acquired knowledge from the sensed environment is correlated with the forehand knowledge of the recorded environment (terrain, cultural features, threats, and targets), which is then used to determine an appropriate evasive maneuver if a nonconformity of the sensed and recorded environments is observed. This four-fold research effort was evaluated in both fixed-based and moving-based real-time piloted simulations, thereby, providing a practical demonstration for evaluating pilot acceptance of the automated concepts, supervisory override, manual operation, and re-engagement of the automatic system. Volume one describes the major components of the guidance and control laws as well as the results of the piloted simulations. Volume two describes the complete mathematical model of the fully automatic guidance system for rotorcraft NOE flight following planned flight profiles.

  2. Planning and Conducting a Functional Exercise. Helpful Hints for School Emergency Management. Volume 2, Issue 4, 2007

    ERIC Educational Resources Information Center

    US Department of Education, 2007

    2007-01-01

    A key component of comprehensive school and school district emergency management plans is an exercise program that includes the five types of exercises: (1) orientation seminars; (2) drills; (3) tabletop exercises; and (4) functional exercises. Functional exercises are excellent tools for testing the extent to which an existing emergency…

  3. Updating and Maintaining School Emergency Management Plans. Helpful Hints for School Emergency Management. Volume 2, Issue 3, 2007

    ERIC Educational Resources Information Center

    US Department of Education, 2007

    2007-01-01

    "Helpful Hints" offers a quick overview of school emergency preparedness topics that are frequently the subject of inquiries. Developing and implementing comprehensive, multi-hazard emergency management plans is an ongoing process that must be consistently reinforced and strengthened. Opportunities for reviewing, strengthening and updating…

  4. Steps for Developing a School Emergency Management Plan. Helpful Hints for School Emergency Management. Volume 2, Issue 1

    ERIC Educational Resources Information Center

    US Department of Education, 2007

    2007-01-01

    The U.S. Department of Education's Office of Safe and Drug-Free Schools strongly encourages schools and school districts to develop emergency management plans within the context of the four phases of emergency management: prevention, mitigation, preparedness, response and recovery. In addition, schools should collaborate closely with police, fire…

  5. Site characterization plan: Yucca Mountain site, Nevada research and development area, Nevada: Consultation draft, Nuclear Waste Policy Act: Volume 2

    SciTech Connect

    1988-01-01

    The Yucca Mountain site in Nevada is one of three candidate sites for the first geologic repository for radioactive waste. On May 28, 1986, it was recommended for detailed study in a program of site characterization. This site characterization plan (SCP) has been prepared in accordance with the requirements of the Nuclear Waste Policy Act to summarize the information collected to date about the geologic conditions at the site; to describe the conceptual designs for the repository and the waste package and to present the plans for obtaining the geologic information necessary to demonstrate the suitability of the site for a repository, to design the repository and the waste package, to prepare an environmental impact statement, and to obtain from the US Nuclear Regulatory Commission (NRC) an authorization to construct the repository. Chapter 3 summarizes present knowledge of the regional and site hydrologic systems. The purpose of the information presented is to (1) describe the hydrology based on available literature and preliminary site-exploration activities that have been or are being performed and (2) provide information to be used to develop the hydrologic aspects of the planned site characterization program. Chapter 4 contains geochemical information about the Yucca Mountain site. The chapter references plan for continued collection of geochemical data as a part of the site characterization program. Chapter 4 describes and evaluates data on the existing climate and site meterology, and outlines the suggested procedures to be used in developing and validating methods to predict future climatic variation. 534 refs., 100 figs., 72 tabs.

  6. A Bibliography of Literature on Planned or Implemented Automated Library Projects, Part I; Volume 9, World Survey Series.

    ERIC Educational Resources Information Center

    Patrinostro, Frank S., Comp.; Sanders, Nancy P., Ed.

    The primary purposes of this bibliography are to present an overview of published works which relate to the use of new technologies in library operations, to call attention to a number of valuable reference works published on the subject, and to assist librarians and library systems scientists who are engaged in the planning and/or implementation…

  7. Chaos Theory & Higher Education: Leadership, Planning, & Policy. Higher Education: Questions about the Purpose(s) of Colleges & Universities. Volume 9.

    ERIC Educational Resources Information Center

    Cutright, Marc, Ed.

    This anthology considers some ways that chaos theory might be not only a descriptive metaphor for the conditions of leadership, planning, and policy in higher education, but also a prescriptive metaphor that might be used to improve these functions and others. The essays are: (1) "Introduction: Metaphor, Chaos Theory, and This Book" (Marc…

  8. Government Performance and Results Act: Performance plan FY 1999, U.S. Nuclear Regulatory Commission. Volume 1

    SciTech Connect

    Fuches, J.L.

    1998-02-01

    The Nuclear Regulatory Commission`s (NRC) strategic plan [NUREG-1614, Vol. 1, September 1997] establishes a strategic framework that will guide future decision-making and will help the NRC continue to meet its responsibility for protecting public health and safety, promoting the common defense and security, and protecting the environment. This performance plan complements the agency`s strategic plan by setting annual goals with measurable target levels of performance for FY 1999, as required by the Government Performance and Results Act. No significant contribution was made to the preparation of the performance plan by any non-Federal entity. However, a contractor was used to help facilitate discussions and resolution of issues. Within six months after the close of FY 1999, the NRC will submit to the President and the Congress a report on program performance for FY 1999. This performance report will review the success of the agency in achieving the performance goals established for FY 1999. Where those goals have been achieved, the underlying assumptions and strategies will be examined to ensure that continued applicability is warranted in the future. If any of the FY 1999 performance goals are not met, the agency will conduct a thorough analysis of why it did not meet the goal and the actions necessary to meet-the goal in the future. One result of this analysis will be the documentation of plans and schedules for achieving the established performance goal. If the analysis should indicate that the performance goal is impractical or infeasible, the performance report will document why that is the case and what action is recommended.

  9. SU-E-T-288: Dose Volume Population Histogram (DVPH): A New Method to Evaluate Intensity Modulated Proton Therapy Plans With Geometrical Uncertainties

    SciTech Connect

    Nguyen, T; Mai, N; Nguyen, B

    2015-06-15

    Purpose: In Proton therapy, especially intensity modulated proton therapy(IMPT), the dose distribution shape is very sensitive to errors due to sharp dose gradients at the Bragg peaks. The concept of the conventional margin is based on the assumption that dose distribution is shifted rather than deformed due to geometrical uncertainties. The goal of this study is to access the validity of the margin concept as well as propose a new approach using Dose Volume Population Histogram (DVPH) in evaluating IMPT plans. Methods: For a prostate case, an intensity modulated proton therapy is optimized based on the conventional PTV based objective function. The plan is evaluated based on the PTV DVH and CTV DVPH (dose volume population histogram) which explicitly taking into account geometric uncertainties. The DVPH is calculated based on 2197 dose distributions at different CTV possible positions for both random and systematic errors. The DVPH with a 90% confidence level is used for the comparison. Results: The minimum dose of the CTV DVPH with a 90% confidence level is only about 18% of the prescribed dose, while the minimum dose of the PTV is 95%. For bladder DVHs, the D50 and D35 is 26% and 30%, compared to 65% and 70% of the prescribed dose from the bladder DVPH with 90% confidence level. Conclusion: The results showed that the PTV concept for ensuring the prescribed dose actually delivered to the CTV is invalid in proton therapy. The good PTV DVH might Result in an underdose to the target and should not be used for IMPT optimization. For OARs, the conventional evaluation approach underestimates dose volume end points. The new concept DVPH has been proved to provide a more accurate DVH evaluation in proton therapy.

  10. Photovoltaic system criteria documents. Volume 1: Guidelines for evaluating the management and operations planning of photovoltaic applications

    NASA Technical Reports Server (NTRS)

    Koenig, John C.; Billitti, Joseph W.; Tallon, John M.

    1979-01-01

    Guidelines are provided to the Field Centers for organization, scheduling, project and cost control, and performance in the areas of project management and operations planning for Photovoltaics Test and Applications. These guidelines may be used in organizing a T and A Project Team for system design/test, site construction and operation, and as the basis for evaluating T and A proposals. The attributes are described for project management and operations planning to be used by the Field Centers. Specifically, all project management and operational issues affecting costs, schedules and performance of photovoltaic systems are addressed. Photovoltaic tests and applications include residential, intermediate load center, central station, and stand-alone systems. The sub-categories of system maturity considered are: Initial System Evaluation Experiments (ISEE); System Readiness Experiments (SRE); and Commercial Readiness Demonstration Projects (CRDP).

  11. SSTAC/ARTS review of the draft Integrated Technology Plan (ITP). Volume 3: Space power and thermal management

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Viewgraphs of briefings from the SSTAC/ARTS review of the draft integrated technology plan on thermal power and thermal management are presented. Topics covered include: space energy conversion research and technology; space photovoltaic energy conversion; chemical energy conversion and storage; thermal energy conversion; power management; thermal management; space nuclear power; high capacity power; surface power and thermal management; space platforms power and thermal management; and project SELENE.

  12. Strategic Management for Organizational Effectiveness. The Effect of Human Resource Planning on Retention and Related Issues. Volume 3.

    DTIC Science & Technology

    1984-12-01

    Koolhaas, Jan. Organization Dissonance and Change. New York: Wiley, 1982. Kotler , Philip . Marketing Management: Analysis. Plannin2. and Control. 5th...Employment Relationship." Econometrica, 1951, 19, 293-305. Slater, Philip E. "Some Social Consequences of Temporary Systems." in W.G. Bennis and P.E...and Philip W. Yetton. Leadershin and Decision Making. Pittsburgh: University of Pittsburgh Press, 1973. Walker, James W. Human Resource Planning. New

  13. Site characterization plan: Yucca Mountain site, Nevada research and development area, Nevada: Consultation draft, Nuclear Waste Policy Act: Volume 7

    SciTech Connect

    1988-01-01

    The Yucca Mountain site in Neavada is one of three candidate sites for the first geologic repository for radioactive waste. On May 28, 1986, it was recommended and approved for detailed study in a program of site characterization. This site characterization plan (SCP) has been prepared in accordance with the requirements of the Nuclear Waste Policy Act to summarize the information collected to date about the geologic conditions at the site;to describe the conceptual designs for the repository and the waste package;and to present the plans for obtaining hte geologic information necessary to demonstrate the suitability of the site for a repository, to design the repository and the waste package, to prepare and environmental impact statement, and to obtain from the US Nuclear Regulatory Commission (NRC) an authorization to construct the repository. This introduction begins with a brief section on the process for siting and developing a repository, followed by a discussion of the pertinent legislation and regulations. A description of site characterization is presented next;it describes the facilities to be constructed for the site characterization program and explains the principal activities to be conducted during the program. Finally, the purpose, content, organizing principles, and organization of this site characterization plan are outlined, and compliance with applicable regulations is discussed.

  14. Site characterization plan: Yucca Mountain site, Nevada research and development area, Nevada: Consultation draft, Nuclear Waste Policy Act: Volume 4

    SciTech Connect

    1988-01-01

    The Yucca Mountain site in Nevada is one of three candidate sites for the first geologic repository for radioactive waste. On May 28, 1986, it was recommended and approved by the President for detailed study in a program of site characterization. This site characterization plan (SCP) has been prepared in accordance with the requirements of the Nuclear Waste Policy Act to summarize the information collected to date about the geologic conditions at the site; to describe the conceptual designs for the repository and the waste package; and to present the plans for obtaining the geologic information necessary to demonstate the suitability of the site for a repository, to desin the repository and the waste package, to prepare an environmental impact statement, and to obtain from the US Nuclear Regulatory Commission (NRC) an authorization to construct the repository. This introduction begins with a brief section on the process for siting and developing a repository, followed by a discussion of the pertinent legislation and regulations. A description of site characterization is presented next; it describes the facilities to be constructed for the site characterization program and explains the principal activities to be conducted during the program. Finally, the purpose, content, organizing principles, and organization of this site characterization plan are outlined, and compliance with applicable regulations is discussed.

  15. Site characterization plan: Yucca Mountain site, Nevada research and development area, Nevada: Consultation draft, Nuclear Waste Policy Act: Volume 6

    SciTech Connect

    1988-01-01

    The Yucca Mountain site in Nevada is one of three candidate sites for the first geologic repository for radioactive waste. On May 28, 1986, it was recommended for detailed study in a program of site characterization. This site characterization plan (SCP) has been prepared in accordance with the requirements of the Nuclear Waste Policy Act to summarize the information collected to date about the geologic conditions at the site;to describe the conceptual designs for the repository and the waste package;and to present the plans for obtaining the geologic information necessary to demonstrate the suitability of the site for repository, to design the repository and the waste package, to prepare an environmental impact statement, and to obtain from the US Nuclear Regulatory Commission (NRC) an authorization to construct the repository. This introduction begins with a brief section on the process for siting and developing a repository, followed by a discussion of the pertinent legislation and regulations. A description of site characterization is presented next;it describes the facilities to be constructed for the site characterization program and explains the principal activities to be conducted during the program. Finally, the purpose, content, organizing principles, and organization of this site characterization plan are outlined, and compliance with applicable regulations is discussed.

  16. Site characterization plan: Yucca Mountain site, Nevada research and development area, Nevada: Consultation draft, Nuclear Waste Policy Act: Volume 1

    SciTech Connect

    1988-01-01

    The Yucca Mountain site in Nevada is one of three candidate sites for the first geologic repository for radioactive waste. On May 28, 1986, it was recommended for detailed study in a program of site characterization. This site characterization plan (SCP) has been prepared in acordance with the requirements of the Nuclear Waste Policy Act to summarize the information collected to date about the geologic conditions at the site;to describe the conceptual designs for the repository and the waste package and to present the plans for obtaining the geologic information necessary to demonstrate the suitability of the site for a repository, to design the repository and the waste package, to prepare an environmental impact statement, and to obtain from the US Nuclear Regulatory Commission (NRC) an authorization to construct the repository. This introduction begins with a brief section on the process for siting and eveloping a repository, followed by a discussion of the pertinent legislation and regulations. A description of site characterization is presented next;it describes the facilities to be constructed for the site characterization program and explains the principal activities to be conducted during the program. Finally, the purpose, content, organizing prinicples, and organization of this site characterization plan are outlined, and compliance with applicable regulations is discussed. 880 refs., 130 figs., 25 tabs.

  17. Woodbridge Army Research Facility RI/FS; volume 1. Field sampling plan. Report for 1995-1996

    SciTech Connect

    Choynowski, J.; Ehlers, M.; Elias, M.; Garcia, M.; Henry, C.

    1996-02-01

    U.S. Army Woodbridge Research Facility (WRF) was used in the past as a major military communications center and a research and development laboratory where electromagnetic pulse energy was tested on military and other equipment. WRF is presently an inactive facility pursuant to the 1991 Base Realignment and Closure list. Past investigation activities indicate that polychlorinated biphenyl compounds (PCBs) are primary chemicals of concern. The WRF is presently in the process of being turned over to the United States Fish and Wildlife Service (USFWS) to be used as a wildlife refuge and training facility. This task calls for provision of the necessary staff and equipment to provide remedial investigation/feasibility support for the USAEC BRAC Program investigation at WRF. The scope of work includes Focused Feasibility Studies, Remedial Investigations, Feasibility Studies, ecological assessments, risk assessments, proposed plans, RODs, and community relations support. This Field Sampling Plan contains a description of the site, sample location rationale, technical approach to field operations, site safety procedures, and methods for ecological assessments, analyses of samples, data management, and disposal of investigation-derived wastes. Information contained in other plans which accompany this submittal is identified.

  18. Resource Management Plan for the Oak Ridge Reservation: Volume 22, Resource information and site analysis for planning on the Oak Ridge Reservation

    SciTech Connect

    Chance, W.W.

    1986-12-01

    The Department of Energy's (DOE's) Oak Ridge Reservation (ORR) consists of approximately 15,000 ha (37,000 acres) of federally owned lands; it contains three major facilities (Oak Ridge Gaseous Diffusion Plant, Oak Ridge National Laboratory, and the Oak Ridge Y-12 Plant) operated by a single contractor and a number of other facilities operated either by DOE or under contract to others. This report documents the various land use elements, land use constraints (physical, programmatic, and geopolitical), and site potential capabilities and provides current documentation of related data for making land use and site development decisions. The ORR has physical, programmatic, and geopolitical constraints that have been identified, measured, and mapped. The constraints and opportunities map was used to identify developable land areas. Many of these sites have only remote potential for meeting any planned needs for expansion of existing facilities. However, stand-alone research functions or other facilities are possible on these sites. These studied and measured findings lead to the conclusion that extreme care must be taken in the evaluation of future use or disposition of available land. Furthermore, it is time to consider and evaluate the feasibility for renewal. The potential for recycling lands formerly used by programs and functions that have been completed or terminated is very real, considering the age, condition, and obsolescence of these facilities.

  19. Phantom investigation of 3D motion-dependent volume aliasing during CT simulation for radiation therapy planning

    PubMed Central

    Tanyi, James A; Fuss, Martin; Varchena, Vladimir; Lancaster, Jack L; Salter, Bill J

    2007-01-01

    Purpose To quantify volumetric and positional aliasing during non-gated fast- and slow-scan acquisition CT in the presence of 3D target motion. Methods Single-slice fast, single-slice slow, and multi-slice fast scan helical CTs were acquired of dynamic spherical targets (1 and 3.15 cm in diameter), embedded in an anthropomorphic phantom. 3D target motions typical of clinically observed tumor motion parameters were investigated. Motion excursions included ± 5, ± 10, and ± 15 mm displacements in the S-I direction synchronized with constant displacements of ± 5 and ± 2 mm in the A-P and lateral directions, respectively. For each target, scan technique, and motion excursion, eight different initial motion-to-scan phase relationships were investigated. Results An anticipated general trend of target volume overestimation was observed. The mean percentage overestimation of the true physical target volume typically increased with target motion amplitude and decreasing target diameter. Slow-scan percentage overestimations were larger, and better approximated the time-averaged motion envelope, as opposed to fast-scans. Motion induced centroid misrepresentation was greater in the S-I direction for fast-scan techniques, and transaxial direction for the slow-scan technique. Overestimation is fairly uniform for slice widths < 5 mm, beyond which there is gross overestimation. Conclusion Non-gated CT imaging of targets describing clinically relevant, 3D motion results in aliased overestimation of the target volume and misrepresentation of centroid location, with little or no correlation between the physical target geometry and the CT-generated target geometry. Slow-scan techniques are a practical method for characterizing time-averaged target position. Fast-scan techniques provide a more reliable, albeit still distorted, target margin. PMID:17319965

  20. Coregistration of Prechemotherapy PET-CT for Planning Pediatric Hodgkin's Disease Radiotherapy Significantly Diminishes Interobserver Variability of Clinical Target Volume Definition

    SciTech Connect

    Metwally, Hussein; Courbon, Frederic; David, Isabelle; Filleron, Thomas; Blouet, Aurelien; Rives, Michel; Izar, Francoise; Zerdoud, Slimane; Plat, Genevieve; Vial, Julie; Robert, Alain; Laprie, Anne

    2011-07-01

    Purpose: To assess the interobserver variability in clinical target volume (CTV) definitions when using registered {sup 18}F-labeled deoxyglucose positron emission tomography (FDG-PET-CT) versus side-by-side image sets in pediatric Hodgkin's disease (HD). Methods and Materials: Prechemotherapy FDG-PET-CT scans performed in the treatment position were acquired from 20 children (median age, 14 years old) with HD (stages 2A to 4B) and registered with postchemotherapy planning CT scans. The patients had a median age of 14 years and stages of disease ranging between 2A and 4B. Image sets were coregistered using a semiautomatic coregistration system. The biological target volume was defined on all the coregistered images as a guide to defining the initial site of involvement and to avoid false-positive or negative results. Five radiation oncologists independently defined the CTV for all 20 patients: once using separate FDG-PET-CT images as a guide (not registered) to define CTVa and once using the registered FDG-PET-CT data to define CTVb. The total volumes were compared, as well as their coefficients of variation (COV). To assess the interobserver variability, the percentages of intersection between contours drawn by all observers for each patient were calculated for CTVa and for CTVb. Results: The registration of a prechemotherapy FDG-PET-CT scan caused a change in the CTV for all patients. Comparing CTVa with CTVb showed that the mean CTVb increased in 14 patients (range, 0.61%-101.96%) and decreased in 6 patients (range, 2.97%-37.26%). The COV for CTVb significantly decreased for each patient; the mean COVs for CTVa and CTVb were 45% (21%-65%) and 32% (13%-57%), respectively (p = 0.0004). The percentage of intersection among all CTVbs for the five observers increased significantly by 89.77% (1.99%-256.41%) compared to that of CTVa (p = 0.0001). Conclusions: High observer variability can occur during CT-based definition of CTVs for children diagnosed with HD

  1. A study on planning organ at risk volume for the rectum using cone beam computed tomography in the treatment of prostate cancer

    SciTech Connect

    Prabhakar, Ramachandran; Oates, Richard; Jones, Daryl; Kron, Tomas; Cramb, Jim; Foroudi, Farshad; Geso, Moshi; Gill, Suki

    2014-04-01

    In this study, we analyzed planning organ at risk volume (PRV) for the rectum using a series of cone beam computed tomographies (CBCTs) acquired during the treatment of prostate cancer and evaluated the dosimetric effect of different PRV definitions. Overall, 21 patients with prostate cancer were treated radically with 78 Gy in 39 fractions had in total 418 CBCTs, each acquired at the end of the first 5 fractions and then every alternate fraction. The PRV was generated from the Boolean sum volume of the rectum obtained from first 5 fractions (PRV-CBCT-5) and from all CBCTs (PRV-CBCT-All). The PRV margin was compared at the superior, middle, and inferior slices of the contoured rectum to compare PRV-CBCT-5 and PRV-CBCT-All. We also compared the dose received by the planned rectum (Rectum-computed tomography [CT]), PRV-CBCT-5, PRV-CBCT-All, and average rectum (CBCT-AV-dose-volume histogram [DVH]) at critical dose levels. The average measured rectal volume for all 21 patients for Rectum-CT, PRV-CBCT-5, and PRV-CBCT-All was 44.3 ± 15.0, 92.8 ± 40.40, and 121.5 ± 36.7 cm{sup 3}, respectively. For PRV-CBCT-All, the mean ± standard deviation displacement in the anterior, posterior, right, and left lateral directions in centimeters was 2.1 ± 1.1, 0.9 ± 0.5, 0.9 ± 0.8, and 1.1 ± 0.7 for the superior rectum; 0.8 ± 0.5, 1.1 ± 0.5, 1.0 ± 0.5, and 1.0 ± 0.5 for the middle rectum; and 0.3 ± 0.3; 0.9 ± 0.5; 0.4 ± 0.2, and 0.5 ± 0.3 for the inferior rectum, respectively. The first 5 CBCTs did not predict the PRV for individual patients. Our study shows that the PRV margin is different for superior, middle, and the inferior parts of the rectum, it is wider superiorly and narrower inferiorly. A uniform PRV margin does not represent the actual rectal variations during treatment for all treatment fractions. The large variation in interpatient rectal size implies a potential role for adaptive radiotherapy for prostate cancer.

  2. Coregistration of prechemotherapy PET-CT for planning pediatric Hodgkin's disease radiotherapy significantly diminishes interobserver variability of clinical target volume definition.

    PubMed

    Metwally, Hussein; Courbon, Frédéric; David, Isabelle; Filleron, Thomas; Blouet, Aurélien; Rives, Michel; Izar, Françoise; Zerdoud, Slimane; Plat, Geneviève; Vial, Julie; Robert, Alain; Laprie, Anne

    2011-07-01

    To assess the interobserver variability in clinical target volume (CTV) definitions when using registered (18)F-labeled deoxyglucose positron emission tomography (FDG-PET-CT) versus side-by-side image sets in pediatric Hodgkin's disease (HD). Prechemotherapy FDG-PET-CT scans performed in the treatment position were acquired from 20 children (median age, 14 years old) with HD (stages 2A to 4B) and registered with postchemotherapy planning CT scans. The patients had a median age of 14 years and stages of disease ranging between 2A and 4B. Image sets were coregistered using a semiautomatic coregistration system. The biological target volume was defined on all the coregistered images as a guide to defining the initial site of involvement and to avoid false-positive or negative results. Five radiation oncologists independently defined the CTV for all 20 patients: once using separate FDG-PET-CT images as a guide (not registered) to define CTVa and once using the registered FDG-PET-CT data to define CTVb. The total volumes were compared, as well as their coefficients of variation (COV). To assess the interobserver variability, the percentages of intersection between contours drawn by all observers for each patient were calculated for CTVa and for CTVb. The registration of a prechemotherapy FDG-PET-CT scan caused a change in the CTV for all patients. Comparing CTVa with CTVb showed that the mean CTVb increased in 14 patients (range, 0.61%-101.96%) and decreased in 6 patients (range, 2.97%-37.26%). The COV for CTVb significantly decreased for each patient; the mean COVs for CTVa and CTVb were 45% (21%-65%) and 32% (13%-57%), respectively (p = 0.0004). The percentage of intersection among all CTVbs for the five observers increased significantly by 89.77% (1.99%-256.41%) compared to that of CTVa (p = 0.0001). High observer variability can occur during CT-based definition of CTVs for children diagnosed with HD. Registration of FDG-PET and planning CT images resulted in

  3. Geopressured-Geothermal Drilling and Testing Plan, Volume II, Testing Plan; Dow Chemical Co. - Dept. of Energy Dow-DOE Sweezy No. 1 Well, Vermilion Parish, Louisiana

    SciTech Connect

    1982-02-01

    The Dow/D.O.E. L. R. Sweezy No. 1 geopressured geothermal production well was completed in August of 1981. The well was perforated and gravel packed in approximately 50 feet of sand from 13,344 feet to 13,395 feet. Permeabilities of 6 to 914 millidarcies were measured with porosity of 25 to 36%. Static surface pressure after well clean-up was 5000 psi. At 1000 B/D flow rate the drawdown was 50 psi. The water produced in clean-up contained 100,000 ppm TDS. This report details the plan for testing this well with the goal of obtaining sufficient data to define the total production curve of the small, 939 acre, reservoir. A production time of six to nine months is anticipated. The salt water disposal well is expected to be completed and surface equipment installed such that production testing will begin by April 1, 1982. The program should be finished and reports written by February 28, 1983. The brine will be produced from the No.1 well, passed through a separator where the gas is removed, then reinjected into the No.2 (SWD) well under separator pressure. Flow rates of up to 25,000 B/D are expected. The tests are divided into a two-week short-term test and six to nine-month long-term tests with periodic downhole measurement of drawdown and buildup rates. Data obtained in the testing will be relayed by phoneline computer hookup to Otis Engineering in Dallas, Texas, where the reservoir calculations and modeling will be done. At the point where sufficient data has been obtained to reach the objectives of the program, production will be ended, the wells plugged and abandoned, and a final report will be issued.

  4. Tracking and data system support for the Viking 1975 mission to Mars. Volume 1: Prelaunch planning, implementation, and testing

    NASA Technical Reports Server (NTRS)

    Mudgway, D. J.; Traxler, M. R.

    1977-01-01

    The tracking and data acquisition support for the 1975 Viking Missions to Mars is described. The history of the effort from its inception in late 1968 through the launches of Vikings 1 and 2 from Cape Kennedy in August and September 1975 is given. The Viking mission requirements for tracking and data acquisition support in both the near earth and deep space phases involved multiple radar tracking and telemetry stations, and communications networks together with the global network of tracking stations, communications, and control center. The planning, implementation, testing and management of the program are presented.

  5. Operationally efficient propulsion system study (OEPSS) data book. Volume 9; Preliminary Development Plan for an Integrated Booster Propulsion Module (BPM)

    NASA Technical Reports Server (NTRS)

    DiBlasi, Angelo G.

    1992-01-01

    A preliminary development plan for an integrated propulsion module (IPM) is described. The IPM, similar to the Space Transportation Main engine (STME) engine, is applicable to the Advanced Launch System (ALS) baseline vehicle. The same STME development program ground rules and time schedule were assumed for the IPM. However, the unique advantages of testing an integrated engine element, in terms of reduced number of hardware and number of system and reliability tests, compared to single standalone engine and MPTA, are highlighted. The potential ability of the IPM to meet the ALS program goals for robustness, operability and reliability is emphasized.

  6. Handbook for Evaluation and Life Cycle Planning for Software. Volume 4. Test and Independent Verification and Validation.

    DTIC Science & Technology

    1983-02-01

    CPCI configuration to which ( ) the test plan applies specifically been identified? (b.) C. TESi CONCt.PTs (7) Is there sufficient background...4 N ’ ~. . 4 4 C " rr . * / WY4 /4 4’ V -. i~?’- ti 4 ,A.4 "’.4. ,. awr sIX .4 -4’...-- 44 *4$~ p4W .3 𔃻 - C . . 4’ . 𔃾: t’ S 9 V IgV Ř -~ -.~ StAr’ie K-A *1I ~+ ~ ’w r~’.t . 44 1 i ~.( F’ . . 4 ~ "-’trw *

  7. A Study of United States Army Family Housing Standardized Plans (PX-0001-5-0835). Volume 1

    DTIC Science & Technology

    1986-05-01

    New Mexico . Arizona and part of Wyoming to its territory. The westward movement of settlers, fur traders and fortune seekers added to Army mobilization...such as old mission structures. The 1856 AnnuMa Report of the Secretary of War stated that the posts in Texas and New Mexico were on rented land and that...Plan Nos: 172; 2-624 3pl . J-4 Basic unit built as a double set of 1902 quarters. The pantry has been eliminated and the kitchen wing is no longer

  8. SU-E-T-513: Investigating Dose of Internal Target Volume After Correcting for Tissue Heterogeneity in SBRT Lung Plans with Homogeneity Calculation

    SciTech Connect

    Qi, P; Zhuang, T; Magnelli, A; Djemil, T; Shang, Q; Balik, S; Andrews, M; Stephans, K; Videtic, G; Xia, P

    2015-06-15

    Purpose It was recommended to use the prescription of 54 Gy/3 with heterogeneity corrections for previously established dose scheme of 60 Gy/3 with homogeneity calculation. This study is to investigate dose coverage for the internal target volume (ITV) with and without heterogeneity correction. Methods Thirty patients who received stereotactic body radiotherapy (SBRT) to a dose of 60 Gy in 3 fractions with homogeneous planning for early stage non-small-cell lung cancer (NSCLC) were selected. ITV was created either from 4DCT scans or a fusion of multi-phase respiratory scans. Planning target volume (PTV) was a 5 mm expansion of the ITV. For this study, we recalculated homogeneous clinical plans using heterogeneity corrections with monitor units set as clinically delivered. All plans were calculated with 3 mm dose grids and collapsed cone convolution algorithm. To account for uncertainties from tumor delineation and image-guided radiotherapy, a structure ITV2mm was created by expanding ITV with 2 mm margins. Dose coverage to the PTV, ITV and ITV2mm were compared with a student paired t-test. Results With heterogeneity corrections, the PTV V60Gy decreased by 10.1% ± 18.4% (p<0.01) while the maximum dose to the PTV increased by 3.7 ± 4.3% (p<0.01). With and without corrections, D99% was 65.8 ± 4.0 Gy and 66.7 ± 4.8 Gy (p=0.15) for the ITV, and 63.9 ± 3.4 Gy and 62.9 ± 4.6 Gy for the ITV2mm (p=0.22), respectively. The mean dose to the ITV and ITV2mm increased 3.6% ± 4.7% (p<0.01) and 2.3% ± 5.2% (p=0.01) with heterogeneity corrections. Conclusion After heterogeneity correction, the peripheral coverage of the PTV decreased to approximately 54 Gy, but D99% of the ITV and ITV2mm was unchanged and the mean dose to the ITV and ITV2mm was increased. Clinical implication of these results requires more investigation.

  9. Alaska Regional Energy Resources Planning Project. Phase 2: coal, hydroelectric and energy alternatives. Volume I. Beluga Coal District Analysis

    SciTech Connect

    Rutledge, G.; Lane, D.; Edblom, G.

    1980-01-01

    This volume deals with the problems and procedures inherent in the development of the Beluga Coal District. Socio-economic implications of the development and management alternatives are discussed. A review of permits and approvals necessary for the initial development of Beluga Coal Field is presented. Major land tenure issues in the Beluga Coal District as well as existing transportation routes and proposed routes and sites are discussed. The various coal technologies which might be employed at Beluga are described. Transportation options and associated costs of transporting coal from the mine site area to a connecting point with a major, longer distance transportation made and of transporting coal both within and outside (exportation) the state are discussed. Some environmental issues involved in the development of the Beluga Coal Field are presented. (DMC)

  10. Life sciences payload definition and integration study, task C and D. Volume 2: Payload definition, integration, and planning studies

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The Life Sciences Payload Definition and Integration Study was composed of four major tasks. Tasks A and B, the laboratory definition phase, were the subject of prior NASA study. The laboratory definition phase included the establishment of research functions, equipment definitions, and conceptual baseline laboratory designs. These baseline laboratories were designated as Maxi-Nom, Mini-30, and Mini-7. The outputs of Tasks A and B were used by the NASA Life Sciences Payload Integration Team to establish guidelines for Tasks C and D, the laboratory integration phase of the study. A brief review of Tasks A and B is presented provide background continuity. The tasks C and D effort is the subject of this report. The Task C effort stressed the integration of the NASA selected laboratory designs with the shuttle sortie module. The Task D effort updated and developed costs that could be used by NASA for preliminary program planning.

  11. Department of Energy plan for recovery and utilization of nuclear byproducts from defense wastes. Volume 1. Executive summary

    SciTech Connect

    1983-08-01

    Nuclear byproducts are a major national resource that has yet to be incorporated into the economy. The current Defense Byproducts Program is designed to match specific military and commercial needs with the availability of valuable products which are currently treated as waste at considerable expense in waste management costs. This program plan focuses on a few specific areas with the greatest potential for near-term development and application. It also recognizes the need for a continuing effort to develop new applications for byproducts and to continue to assess the impacts on waste management. The entire program has been, and will continue to be structured so as to ensure the safety of the public and maintain the purity of the environment. Social and institutional concerns have been recognized and will be handled appropriately. A significant effort will be undertaken to inform the public of the benefits of byproduct use and of the care being taken to ensure safe, efficient operation.

  12. Incorporating global warming risks in power sector planning: A case study of the New England region. Volume 1

    SciTech Connect

    Krause, F.; Busch, J.; Koomey, J.

    1992-11-01

    Growing international concern over the threat of global climate change has led to proposals to buy insurance against this threat by reducing emissions of carbon (short for carbon dioxide) and other greenhouse gases below current levels. Concern over these and other, non-climatic environmental effects of electricity generation has led a number of states to adopt or explore new mechanisms for incorporating environmental externalities in utility resource planning. For example, the New York and Massachusetts utility commissions have adopted monetized surcharges (or adders) to induce emission reductions of federally regulated air pollutants (notably, SO{sub 2}, NO{sub x}, and particulates) beyond federally mandated levels. These regulations also include preliminary estimates of the cost of reducing carbon emissions, for which no federal regulations exist at this time. Within New England, regulators and utilities have also held several workshops and meetings to discuss alternative methods of incorporating externalities as well as the feasibility of regional approaches. This study examines the potential for reduced carbon emissions in the New England power sector as well as the cost and rate impacts of two policy approaches: environmental externality surcharges and a target- based approach. We analyze the following questions: Does New England have sufficient low-carbon resources to achieve significant reductions (10% to 20% below current levels) in fossil carbon emissions in its utility sector? What reductions could be achieved at a maximum? What is the expected cost of carbon reductions as a function of the reduction goal? How would carbon reduction strategies affect electricity rates? How effective are environmental externality cost surcharges as an instrument in bringing about carbon reductions? To what extent could the minimization of total electricity costs alone result in carbon reductions relative to conventional resource plans?

  13. Verification of Planning Target Volume Settings in Volumetric Modulated Arc Therapy for Stereotactic Body Radiation Therapy by Using In-Treatment 4-Dimensional Cone Beam Computed Tomography

    SciTech Connect

    Takahashi, Wataru; Yamashita, Hideomi; Kida, Satoshi; Masutani, Yoshitaka; Sakumi, Akira; Ohtomo, Kuni; Nakagawa, Keiichi; Haga, Akihiro

    2013-07-01

    Purpose: To evaluate setup error and tumor motion during beam delivery by using 4-dimensional cone beam computed tomography (4D CBCT) and to assess the adequacy of the planning target volume (PTV) margin for lung cancer patients undergoing volumetric modulated arc therapy for stereotactic body radiation therapy (VMAT-SBRT). Methods and Materials: Fifteen lung cancer patients treated by single-arc VMAT-SBRT were selected in this analysis. All patients were treated with an abdominal compressor. The gross tumor volumes were contoured on maximum inspiration and maximum expiration CT datasets from 4D CT respiratory sorting and merged into internal target volumes (ITVs). The PTV margin was isotropically taken as 5 mm. Registration was automatically performed using “pre-3D” CBCT. Treatment was performed with a D95 prescription of 50 Gy delivered in 4 fractions. The 4D tumor locations during beam delivery were determined using in-treatment 4D CBCT images acquired in each fraction. Then, the discrepancy between the actual tumor location and the ITV was evaluated in the lateral, vertical, and longitudinal directions. Results: Overall, 55 4D CBCT sets during VMAT-SBRT were successfully obtained. The amplitude of tumor motion was less than 10 mm in all directions. The average displacements between ITV and actual tumor location during treatment were 0.41 ± 0.93 mm, 0.15 ± 0.58 mm, and 0.60 ± 0.99 mm for the craniocaudal, left-right, and anteroposterior directions, respectively. The discrepancy in each phase did not exceed 5 mm in any direction. Conclusions: With in-treatment 4D CBCT, we confirmed the required PTV margins when the registration for moving target was performed using pre-3D CBCT. In-treatment 4D CBCT is a direct method for quantitatively assessing the intrafractional location of a moving target.

  14. Verification of planning target volume settings in volumetric modulated arc therapy for stereotactic body radiation therapy by using in-treatment 4-dimensional cone beam computed tomography.

    PubMed

    Takahashi, Wataru; Yamashita, Hideomi; Kida, Satoshi; Masutani, Yoshitaka; Sakumi, Akira; Ohtomo, Kuni; Nakagawa, Keiichi; Haga, Akihiro

    2013-07-01

    To evaluate setup error and tumor motion during beam delivery by using 4-dimensional cone beam computed tomography (4D CBCT) and to assess the adequacy of the planning target volume (PTV) margin for lung cancer patients undergoing volumetric modulated arc therapy for stereotactic body radiation therapy (VMAT-SBRT). Fifteen lung cancer patients treated by single-arc VMAT-SBRT were selected in this analysis. All patients were treated with an abdominal compressor. The gross tumor volumes were contoured on maximum inspiration and maximum expiration CT datasets from 4D CT respiratory sorting and merged into internal target volumes (ITVs). The PTV margin was isotropically taken as 5 mm. Registration was automatically performed using "pre-3D" CBCT. Treatment was performed with a D95 prescription of 50 Gy delivered in 4 fractions. The 4D tumor locations during beam delivery were determined using in-treatment 4D CBCT images acquired in each fraction. Then, the discrepancy between the actual tumor location and the ITV was evaluated in the lateral, vertical, and longitudinal directions. Overall, 55 4D CBCT sets during VMAT-SBRT were successfully obtained. The amplitude of tumor motion was less than 10 mm in all directions. The average displacements between ITV and actual tumor location during treatment were 0.41 ± 0.93 mm, 0.15 ± 0.58 mm, and 0.60 ± 0.99 mm for the craniocaudal, left-right, and anteroposterior directions, respectively. The discrepancy in each phase did not exceed 5 mm in any direction. With in-treatment 4D CBCT, we confirmed the required PTV margins when the registration for moving target was performed using pre-3D CBCT. In-treatment 4D CBCT is a direct method for quantitatively assessing the intrafractional location of a moving target. Copyright © 2013 Elsevier Inc. All rights reserved.

  15. Impact of 18-fluorodeoxyglucose positron emission tomography on computed tomography defined target volumes in radiation treatment planning of esophageal cancer: reduction in geographic misses with equal inter-observer variability: PET/CT improves esophageal target definition.

    PubMed

    Schreurs, L M A; Busz, D M; Paardekooper, G M R M; Beukema, J C; Jager, P L; Van der Jagt, E J; van Dam, G M; Groen, H; Plukker, J Th M; Langendijk, J A

    2010-08-01

    Target volume definition in modern radiotherapy is based on planning computed tomography (CT). So far, 18-fluorodeoxyglucose positron emission tomography (FDG-PET) has not been included in planning modality in volume definition of esophageal cancer. This study evaluates fusion of FDG-PET and CT in patients with esophageal cancer in terms of geographic misses and inter-observer variability in volume definition. In 28 esophageal cancer patients, gross, clinical and planning tumor volumes (GTV; CTV; PTV) were defined on planning CT by three radiation oncologists. After software-based emission tomography and computed tomography (PET/CT) fusion, tumor delineations were redefined by the same radiation-oncologists. Concordance indexes (CCI's) for CT and PET/CT based GTV, CTV and PTV were calculated for each pair of observers. Incorporation of PET/CT modified tumor delineation in 17/28 subjects (61%) in cranial and/or caudal direction. Mean concordance indexes for CT-based CTV and PTV were 72 (55-86)% and 77 (61-88)%, respectively, vs. 72 (47-99)% and 76 (54-87)% for PET/CT-based CTV and PTV. Paired analyses showed no significant difference in CCI between CT and PET/CT. Combining FDG-PET and CT may improve target volume definition with less geographic misses, but without significant effects on inter-observer variability in esophageal cancer.

  16. Site characterization plan: Conceptual design report: Volume 4, Appendices F-O: Nevada Nuclear Waste Storage Investigations Project

    SciTech Connect

    MacDougall, H R; Scully, L W; Tillerson, J R

    1987-09-01

    The site for the prospective repository is located at Yucca Mountain in southwestern Nevada, and the waste emplacement area will be constructed in the underlying volcanic tuffs. The target horizon for waste emplacement is a sloping bed of densely welded tuff more than 650 ft below the surface and typically more than 600 ft above the water table. The conceptual design described in this report is unique among repository designs in that it uses ramps in addition to shafts to gain access to the underground facility, the emplacement horizon is located above the water table, and it is possible that 300- to 400-ft-long horizontal waste emplacement boreholes will be used. This report summarizes the design bases, design and performance criteria, and the design analyses performed. The current status of meeting the preclosure performance objectives for licensing and of resolving the repository design and preclosure issues is presented. The repository design presented in this report will be expanded and refined during the advanced conceptual design, the license application design, and the final procurement and construction design phases. Volume 4 contains Appendices F to O.

  17. Beam-specific planning target volumes incorporating 4D CT for pencil beam scanning proton therapy of thoracic tumors.

    PubMed

    Lin, Liyong; Kang, Minglei; Huang, Sheng; Mayer, Rulon; Thomas, Andrew; Solberg, Timothy D; McDonough, James E; Simone, Charles B

    2015-11-08

    The purpose of this study is to determine whether organ sparing and target coverage can be simultaneously maintained for pencil beam scanning (PBS) proton therapy treatment of thoracic tumors in the presence of motion, stopping power uncertainties, and patient setup variations. Ten consecutive patients that were previously treated with proton therapy to 66.6/1.8 Gy (RBE) using double scattering (DS) were replanned with PBS. Minimum and maximum intensity images from 4D CT were used to introduce flexible smearing in the determination of the beam specific PTV (BSPTV). Datasets from eight 4D CT phases, using ± 3% uncertainty in stopping power and ± 3 mm uncertainty in patient setup in each direction, were used to create 8 × 12 × 10 = 960 PBS plans for the evaluation of 10 patients. Plans were normalized to provide identical coverage between DS and PBS. The average lung V20, V5, and mean doses were reduced from 29.0%, 35.0%, and 16.4 Gy with DS to 24.6%, 30.6%, and 14.1 Gy with PBS, respectively. The average heart V30 and V45 were reduced from 10.4% and 7.5% in DS to 8.1% and 5.4% for PBS, respectively. Furthermore, the maximum spinal cord, esophagus, and heart doses were decreased from 37.1 Gy, 71.7 Gy, and 69.2 Gy with DS to 31.3 Gy, 67.9 Gy, and 64.6 Gy with PBS. The conformity index (CI), homogeneity index (HI), and global maximal dose were improved from 3.2, 0.08, 77.4 Gy with DS to 2.8, 0.04, and 72.1 Gy with PBS. All differences are statistically significant, with p-values <0.05, with the exception of the heart V45 (p = 0.146). PBS with BSPTV achieves better organ sparing and improves target coverage using a repainting method for the treatment of thoracic tumors. Incorporating motion-related uncertainties is essential.

  18. Beam-specific planning target volumes incorporating 4D CT for pencil beam scanning proton therapy of thoracic tumors.

    PubMed

    Lin, Liyong; Kang, Minglei; Huang, Sheng; Mayer, Rulon; Thomas, Andrew; Solberg, Timothy D; McDonough, James E; Simone, Charles B

    2015-11-01

    The purpose of this study is to determine whether organ sparing and target coverage can be simultaneously maintained for pencil beam scanning (PBS) proton therapy treatment of thoracic tumors in the presence of motion, stopping power uncertainties, and patient setup variations. Ten consecutive patients that were previously treated with proton therapy to 66.6/1.8 Gy (RBE) using double scattering (DS) were replanned with PBS. Minimum and maximum intensity images from 4D CT were used to introduce flexible smearing in the determination of the beam specific PTV (BSPTV). Datasets from eight 4D CT phases, using ±3% uncertainty in stopping power and ±3 mm uncertainty in patient setup in each direction, were used to create 8×12×10=960 PBS plans for the evaluation of 10 patients. Plans were normalized to provide identical coverage between DS and PBS. The average lung V20, V5, and mean doses were reduced from 29.0%, 35.0%, and 16.4 Gy with DS to 24.6%, 30.6%, and 14.1 Gy with PBS, respectively. The average heart V30 and V45 were reduced from 10.4% and 7.5% in DS to 8.1% and 5.4% for PBS, respectively. Furthermore, the maximum spinal cord, esophagus, and heart doses were decreased from 37.1 Gy, 71.7 Gy, and 69.2 Gy with DS to 31.3 Gy, 67.9 Gy, and 64.6 Gy with PBS. The conformity index (CI), homogeneity index (HI), and global maximal dose were improved from 3.2, 0.08, 77.4 Gy with DS to 2.8, 0.04, and 72.1 Gy with PBS. All differences are statistically significant, with p-values <0.05, with the exception of the heart V45 (p=0.146). PBS with BSPTV achieves better organ sparing and improves target coverage using a repainting method for the treatment of thoracic tumors. Incorporating motion-related uncertainties is essential. PACS number: 87.55.D.

  19. Resource management plan for the Oak Ridge Reservation. Volume 29, Rare plants on the Oak Ridge Reservation

    SciTech Connect

    Cunningham, M.; Pounds, L.; Oberholster, S.; Parr, P.; Mann, L.; Edwards, L.; Rosensteel, B.

    1993-08-01

    Rare plant species listed by state or federal agencies and found on or near the Department of Energy`s Oak Ridge Reservation (ORR) are identified. Seventeen species present on the ORR are listed by the Tennessee Department of Environment and Conservation as either endangered, threatened, or of special concern. Four of these are under review by the US Fish and Wildlife Service for possible listing as threatened or endangered species. Ten species listed by the state occur near and may be present on the ORR; four are endangered in Tennessee, and one is a candidate for federal listing. A range of habitats supports the rare taxa on the ORR: River bluffs, calcareous barrens, wetlands, and deciduous forest. Sites for listed rare species on the ORR have been designated as Research Park Natural Areas. Consideration of rare plant habitats is an important component of resource management and land-use planning; protection of rare species in their natural habitat is the best method of ensuring their long-term survival. In addition, the National Environmental Policy Act requires that federally funded projects avoid or mitigate impacts to listed species. The list of rare plant species and their location on the ORR should be considered provisional because the entire ORR has not been surveyed, and state and federal status of all species continues to be updated.

  20. Performance evaluation of Automatic Extraction System. Volume IV. Recommended operating, maintenance, and training plans. Final technical report

    SciTech Connect

    Frantz, R.L.; King, R.H.; Bartsch, D.L.

    1980-07-01

    Since the AES is a different and more sochisticated machine, it became apparent during the in-mine trial that more than on-the-job training (OJT) is desirable for the operators. The AES is unique in that it should remain in the face for long periods rather than be moved often from the face to face. In addition, the operator should learn to trust the ACS in order to be more aware of the hazards in the face area. More training is one way to help increase operator and machine efficiency and safety consciousness. The lack of formal, organized, scheduled, non-productive-mode training of the AES operators appeared to affect the performance of the AES during mining, tramming, maneuvering, and bolting. Therefore, before the operator and bolters do their jobs and the mechanics maintain the AES on a regular basis in a production-mode, they should attend classes, including: (1) formal above ground classroom training, (2) non-productive-mode underground training, and (3) productive-mode OJT. The training department should have the authority and resources to train workers beforehand, and also whenever subsequent instruction is needed. This plan includes only those areas peculiar to the AES. It is assumed that mature, competent individuals (operators and bolters) have already been trained to use similar machines. If this is not the case, the training will require significantly more time.

  1. Recovery Efficiency Test Project: Phase 1, Activity report. Volume 1: Site selection, drill plan preparation, drilling, logging, and coring operations

    SciTech Connect

    Overbey, W.K. Jr.; Carden, R.S.; Kirr, J.N.

    1987-04-01

    The recovery Efficiency Test well project addressed a number of technical issues. The primary objective was to determine the increased efficiency gas recovery of a long horizontal wellbore over that of a vertical wellbore and, more specifically, what improvements can be expected from inducing multiple hydraulic fractures from such a wellbore. BDM corporation located, planned, and drilled a long radius turn horizontal well in the Devonian shale Lower Huron section in Wayne County, West Virginia, demonstrating that state-of-the-art technology is capable of drilling such wells. BDM successfully tested drilling, coring, and logging in a horizontal well using air as the circulating medium; conducted reservoir modeling studies to protect flow rates and reserves in advance of drilling operations; observed two phase flow conditions in the wellbore not observed previously; cored a fracture zone which produced gas; observed that fractures in the core and the wellbore were not systematically spaced (varied from 5 to 68 feet in different parts of the wellbore); observed that highest gas show rates reported by the mud logger corresponded to zone with lowest fracture spacing (five feet) or high fracture frequency. Four and one-half inch casting was successfully installed in the borehole and was equipped to isolate the horizontal section into eight (8) zones for future testing and stimulation operations. 6 refs., 48 figs., 10 tabs.

  2. Dynamic evaluation of airflow rates for a variable air volume system serving an open-plan office.

    PubMed

    Mai, Horace K W; Chan, Daniel W T; Burnett, John

    2003-09-01

    In a typical air-conditioned office, the thermal comfort and indoor air quality are sustained by delivering the amount of supply air with the correct proportion of outdoor air to the breathing zone. However, in a real office, it is not easy to measure these airflow rates supplied to space, especially when the space is served by a variable air volume (VAV) system. The most accurate method depends on what is being measured, the details of the building and types of ventilation system. The constant concentration tracer gas method as a means to determine ventilation system performance, however, this method becomes more complicated when the air, including the tracer gas is allowed to recirculate. An accurate measurement requires significant resource support in terms of instrumentation set up and also professional interpretation. This method deters regular monitoring of the performance of an airside systems by building managers, and hence the indoor environmental quality, in terms of thermal comfort and indoor air quality, may never be satisfactory. This paper proposes a space zone model for the calculation of all the airflow parameters based on tracer gas measurements, including flow rates of outdoor air, VAV supply, return space, return and exfiltration. Sulphur hexafluoride (SF6) and carbon dioxide (CO2) are used as tracer gases. After using both SF6 and CO2, the corresponding results provide a reference to justify the acceptability of using CO2 as the tracer gas. The validity of using CO2 has the significance that metabolic carbon dioxide can be used as a means to evaluate real time airflow rates. This approach provides a practical protocol for building managers to evaluate the performance of airside systems.

  3. Magnetic Resonance Imaging-Based Target Volume Delineation in Radiation Therapy Treatment Planning for Brain Tumors Using Localized Region-Based Active Contour

    SciTech Connect

    Aslian, Hossein; Sadeghi, Mahdi; Mahdavi, Seied Rabie; Babapour Mofrad, Farshid; Astarakee, Mahdi; Khaledi, Navid; Fadavi, Pedram

    2013-09-01

    Purpose: To evaluate the clinical application of a robust semiautomatic image segmentation method to determine the brain target volumes in radiation therapy treatment planning. Methods and Materials: A local robust region-based algorithm was used on MRI brain images to study the clinical target volume (CTV) of several patients. First, 3 oncologists delineated CTVs of 10 patients manually, and the process time for each patient was calculated. The averages of the oncologists’ contours were evaluated and considered as reference contours. Then, to determine the CTV through the semiautomatic method, a fourth oncologist who was blind to all manual contours selected 4-8 points around the edema and defined the initial contour. The time to obtain the final contour was calculated again for each patient. Manual and semiautomatic segmentation were compared using 3 different metric criteria: Dice coefficient, Hausdorff distance, and mean absolute distance. A comparison also was performed between volumes obtained from semiautomatic and manual methods. Results: Manual delineation processing time of tumors for each patient was dependent on its size and complexity and had a mean (±SD) of 12.33 ± 2.47 minutes, whereas it was 3.254 ± 1.7507 minutes for the semiautomatic method. Means of Dice coefficient, Hausdorff distance, and mean absolute distance between manual contours were 0.84 ± 0.02, 2.05 ± 0.66 cm, and 0.78 ± 0.15 cm, and they were 0.82 ± 0.03, 1.91 ± 0.65 cm, and 0.7 ± 0.22 cm between manual and semiautomatic contours, respectively. Moreover, the mean volume ratio (=semiautomatic/manual) calculated for all samples was 0.87. Conclusions: Given the deformability of this method, the results showed reasonable accuracy and similarity to the results of manual contouring by the oncologists. This study shows that the localized region-based algorithms can have great ability in determining the CTV and can be appropriate alternatives for manual approaches in brain cancer.

  4. THE PREPARATION OF CURRICULUM MATERIALS AND THE DEVELOPMENT OF TEACHERS FOR AN EXPERIMENTAL APPLICATION OF THE CLUSTER CONCEPT OF VOCATIONAL EDUCATION AT THE SECONDARY SCHOOL LEVEL. VOLUME II, INSTRUCTIONAL PLANS FOR THE CONSTRUCTION CLUSTER.

    ERIC Educational Resources Information Center

    MALEY, DONALD

    DESIGNED FOR USE WITH 11TH AND 12TH GRADE STUDENTS, THIS CURRICULUM GUIDE FOR THE OCCUPATIONAL CLUSTER IN CONSTRUCTION WAS DEVELOPED BY PARTICIPATING TEACHERS FROM RESULTS OF THE RESEARCH PROCEDURES DESCRIBED IN VOLUME I (VT 004 162). THE COURSE DESCRIPTION, NEED FOR THE COURSE, COURSE OBJECTIVES, PROCEDURE, AND INSTRUCTIONAL PLAN ARE DISCUSSED…

  5. Assessment of Planning Target Volume Margins for Intensity-Modulated Radiotherapy of the Prostate Gland: Role of Daily Inter- and Intrafraction Motion

    SciTech Connect

    Tanyi, James A.; He, Tongming; Summers, Paige A.; Mburu, Ruth G.; Kato, Catherine M.; Rhodes, Stephen M.; Hung, Arthur Y.; Fuss, Martin

    2010-12-01

    Purpose: To determine planning target volume margins for prostate intensity-modulated radiotherapy based on inter- and intrafraction motion using four daily localization techniques: three-point skin mark alignment, volumetric imaging with bony landmark registration, volumetric imaging with implanted fiducial marker registration, and implanted electromagnetic transponders (beacons) detection. Methods and Materials: Fourteen patients who underwent definitive intensity-modulated radiotherapy for prostate cancer formed the basis of this study. Each patient was implanted with three electromagnetic transponders and underwent a course of 39 treatment fractions. Daily localization was based on three-point skin mark alignment followed by transponder detection and patient repositioning. Transponder positioning was verified by volumetric imaging with cone-beam computed tomography of the pelvis. Relative motion between the prostate gland and bony anatomy was quantified by offline analyses of daily cone-beam computed tomography. Intratreatment organ motion was monitored continuously by the Calypso (registered) System for quantification of intrafraction setup error. Results: As expected, setup error (that is, inter- plus intrafraction motion, unless otherwise stated) was largest with skin mark alignment, requiring margins of 7.5 mm, 11.4 mm, and 16.3 mm, in the lateral (LR), longitudinal (SI), and vertical (AP) directions, respectively. Margin requirements accounting for intrafraction motion were smallest for transponder detection localization techniques, requiring margins of 1.4 mm (LR), 2.6 mm (SI), and 2.3 mm (AP). Bony anatomy alignment required 2.1 mm (LR), 9.4 mm (SI), and 10.5 mm (AP), whereas image-guided marker alignment required 2.8 mm (LR), 3.7 mm (SI), and 3.2 mm (AP). No marker migration was observed in the cohort. Conclusion: Clinically feasible, rapid, and reliable tools such as the electromagnetic transponder detection system for pretreatment target localization

  6. MRI versus ⁶⁸Ga-PSMA PET/CT for gross tumour volume delineation in radiation treatment planning of primary prostate cancer.

    PubMed

    Zamboglou, Constantinos; Wieser, Gesche; Hennies, Steffen; Rempel, Irene; Kirste, Simon; Soschynski, Martin; Rischke, Hans Christian; Fechter, Tobias; Jilg, Cordula A; Langer, Mathias; Meyer, Philipp T; Bock, Michael; Grosu, Anca-Ligia

    2016-05-01

    Multiparametric magnetic resonance imaging (mpMRI) is widely used in radiation treatment planning of primary prostate cancer (PCA). Focal dose escalation to the dominant intraprostatic lesions (DIPL) may lead to improved PCA control. Prostate-specific membrane antigen (PSMA) is overexpressed in most PCAs. (68)Ga-labelled PSMA inhibitors have demonstrated promising results in detection of PCA with PET/CT. The aim of this study was to compare (68)Ga-PSMA PET/CT with MRI for gross tumour volume (GTV) definition in primary PCA. This retrospective study included 22 patients with primary PCA analysed after (68)Ga-PSMA PET/CT and mpMRI. GTVs were delineated on MR images by two radiologists (GTV-MRIrad) and two radiation oncologists separately. Both volumes were merged leading to GTV-MRIint. GTVs based on PET/CT were delineated by two nuclear medicine physicians in consensus (GTV-PET). Laterality (left, right, and left and right prostate lobes) on mpMRI, PET/CT and pathological analysis after biopsy were assessed. Mean GTV-MRIrad, GTV-MRIint and GTV-PET were 5.92, 3.83 and 11.41 cm(3), respectively. GTV-PET was significant larger then GTV-MRIint (p = 0.003). The MRI GTVs GTV-MRIrad and GTV-MRIint showed, respectively, 40 % and 57 % overlap with GTV-PET. GTV-MRIrad and GTV-MRIint included the SUVmax of GTV-PET in 12 and 11 patients (54.6 % and 50 %), respectively. In nine patients (47 %), laterality on mpMRI, PET/CT and histopathology after biopsy was similar. Ga-PSMA PET/CT and mpMRI provided concordant results for delineation of the DIPL in 47 % of patients (40 % - 54 % of lesions). GTV-PET was significantly larger than GTV-MRIint. (68)Ga-PSMA PET/CT may have a role in radiation treatment planning for focal radiation to the DIPL. Exact correlation of PET and MRI images with histopathology is needed.

  7. TU-EF-304-02: 4D Optimized Treatment Planning for Actively Scanned Proton Therapy Delivered to Moving Target Volume

    SciTech Connect

    Bernatowicz, K; Zhang, Y; Weber, D; Lomax, A

    2015-06-15

    Purpose: To develop a 4D treatment optimization approach for Pencil Beam Scanned (PBS) proton therapy that includes breathing variability. Method: PBS proton therapy delivers a pattern of proton pencil beams (PBs), distributed to cover the target volume and optimized such as to achieve a homogenous dose distribution across the target. In this work, this optimization step has been enhanced to include advanced 4D dose calculations of liver tumors based on motion extracted from either 4D-CT (representing a single and averaged respiratory cycle) or 4D-CT(MRI) (including breathing variability). The 4D dose calculation is performed per PB on deforming dose grid, and according to the timestamp of each PB, a displacement due to patient’s motion and a change in radiological depth.Three different treatment fields have been optimized in 3D on the end-exhale phase of a 4D-CT liver data set (3D-opt) and then in 4D using the motion extracted from either 4D-CT or 4D-CT(MRI) using deformable image registration. All plans were calculated directly on the PTV without the use of an ITV. The delivery characteristics of the PSI Gantry 2 have been assumed for all calculations. Results: Dose inhomogeneities (D5-D95) in the CTV for the 3D optimized plans recalculated under conditions of variable motion were increased by on average 19.8% compared to the static case. These differences could be reduced by 4D-CT based 4D optimization to 10.5% and by 4D-CT(MRI) based optimization to only 2.3% of the static value. Liver V25 increased by less than 1% using 4D optimization. Conclusion: 4D optimized PBS treatment plans taking into account breathing variability provide for significantly improved robustness against motion and motion variability than those based on 4D-CT alone, and may negate the need of motion specific target expansions. Swiss National Fund Grant (320030-1493942-1)

  8. SU-E-J-76: Incorporation of Ultrasound Elastography in Target Volume Delineation for Partial Breast Radiotherapy Planning: A Comparative Study

    SciTech Connect

    Juneja, P; Harris, E; Bamber, J

    2014-06-01

    Purpose: There is substantial observer variability in the delineation of target volumes for post-surgical partial breast radiotherapy because the tumour bed has poor x-ray contrast. This variability may result in substantial variations in planned dose distribution. Ultrasound elastography (USE) has an ability to detect mechanical discontinuities and therefore, the potential to image the scar and distortion in breast tissue architecture. The goal of this study was to compare USE techniques: strain elastography (SE), shear wave elastography (SWE) and acoustic radiation force impulse (ARFI) imaging using phantoms that simulate features of the tumour bed, for the purpose of incorporating USE in breast radiotherapy planning. Methods: Three gelatine-based phantoms (10% w/v) containing: a stiff inclusion (gelatine 16% w/v) with adhered boundaries, a stiff inclusion (gelatine 16% w/v) with mobile boundaries and fluid cavity inclusion (to mimic seroma), were constructed and used to investigate the USE techniques. The accuracy of the elastography techniques was quantified by comparing the imaged inclusion with the modelled ground-truth using the Dice similarity coefficient (DSC). For two regions of interest (ROI), the DSC measures their spatial overlap. Ground-truth ROIs were modelled using geometrical measurements from B-mode images. Results: The phantoms simulating stiff scar tissue with adhered and mobile boundaries and seroma were successfully developed and imaged using SE and SWE. The edges of the stiff inclusions were more clearly visible in SE than in SWE. Subsequently, for all these phantoms the measured DSCs were found to be higher for SE (DSCs: 0.91–0.97) than SWE (DSCs: 0.68–0.79) with an average relative difference of 23%. In the case of seroma phantom, DSC values for SE and SWE were similar. Conclusion: This study presents a first attempt to identify the most suitable elastography technique for use in breast radiotherapy planning. Further analysis will

  9. SU-C-BRE-02: BED Vs. Local Control: Radiobiological Effect of Tumor Volume in Monte Carlo (MC) Lung SBRT Planning

    SciTech Connect

    Pokhrel, D; Badkul, R; Jiang, H; Estes, C; Park, J; Kumar, P; Wang, F

    2014-06-15

    Purpose: SBRT with hypofractionated dose schemata has emerged a compelling treatment modality for medically inoperable early stage lung cancer patients. It requires more accurate dose calculation and treatment delivery technique. This report presents the relationship between tumor control probability(TCP) and size-adjusted biological effective dose(sBED) of tumor volume for MC lung SBRT patients. Methods: Fifteen patients who were treated with MC-based lung SBRT to 50Gy in 5 fractions to PTVV100%=95% were studied. ITVs were delineated on MIP images of 4DCT-scans. PTVs diameter(ITV+5mm margins) ranged from 2.7–4.9cm (mean 3.7cm). Plans were generated using non-coplanar conformal arcs/beams using iPlan XVMC algorithm (BrainLABiPlan ver.4.1.2) for Novalis-TX with HD-MLCs and 6MVSRS(1000MU/min) mode, following RTOG-0813 dosimetric guidelines. To understand the known uncertainties of conventional heterogeneities-corrected/uncorrected pencil beam (PBhete/ PB-homo) algorithms, dose distributions were re-calculated with PBhete/ PB-homo using same beam configurations, MLCs and monitor units. Biologically effective dose(BED10) was computed using LQ-model with α/β=10Gy for meanPTV and meanITV. BED10-c*L, gave size-adjusted BED(sBED), where c=10Gy/cm and L=PTV diameter in centimeter. The TCP model was adopted from Ohri et al.(IJROBP, 2012): TCP = exp[sBEDTCD50]/ k /(1.0 + exp[sBED-TCD50]/k), where k=31Gy corresponding to TCD50=0Gy; and more realistic MC-based TCP was computed for PTV(V99%). Results: Mean PTV PB-hete TCP value was 6% higher, but, mean PTV PB-homo TCP value was 4% lower compared to mean PTV MC TCP. Mean ITV PB-hete/PB-homo TCP values were comparable (within ±3.0%) to mean ITV MC TCP. The mean PTV(V99%)had BED10=90.9±3.7%(median=92.2%),sBED=54.1±8.2%(median=53.5%) corresponding to mean MC TCP value of 84.8±3.3%(median=84.9%) at 2- year local control. Conclusion: The TCP model which incorporates BED10 and tumor diameter indicates that radiobiological

  10. Contrast-enhanced ultrasound in planning thermal ablation of liver metastases: Should the hypervascular halo be included in the ablation volume?().

    PubMed

    Andreano, A; Meneghel, E; Bovo, G; Ippolito, D; Salvioni, A; Filice, C; Sironi, S; Meloni, M F

    2010-12-01

    Liver metastases often exhibit a hypervascular halo during the arterial phase of contrast-enhanced ultrasonography (CEUS). This finding has no correlates on baseline gray-scale imaging, and it has never been characterized. The aim of this study was to identify the features of this halo and determine whether it should be included in the ablation volume during thermal ablation procedures. We prospectively enrolled 25 patients referred to our department for thermal ablation of liver metastases. Before treatment all patients underwent CEUS, and the maximum diameter of the metastatic lesion was measured before administration of the ultrasound contrast agent and during the arterial and portal venous phases of the contrast contrast-enhanced study. Maximum diameters in the different vascular phases were compared with the Turkey-Kramer test. Two biopsies were obtained from each lesion with a 21-gauge needle: 1) one from the center of the metastasis to confirm the diagnosis and 2) one from the hypervascular peripheral halo identified in the arterial phase at CEUS. The mean (±standard deviation) maximum lesion diameter was 2.67 ± 1.2 cm before contrast agent injection, 3.50 ± 1.4 cm during the arterial phase, and 2.71 ± 1.2 cm during the venous phase. The difference between maximum diameters measured before contrast enhancement and in the arterial phase was highly significant (mean: 0.84 ± 0.45 cm, p < 0.0001). Histological examination of halo specimens revealed inflammatory infiltrates with no evidence of tumor infiltration in 24/25 (96%) cases and normal hepatic parenchymal tissue in the 25th specimen. The hypervascular halo surrounding liver metastases during the arterial phase of CEUS represents a chronic inflammatory infiltrate, not tumor infiltration. However, since chronic inflammation appears to promote neovascularization and the production of tumoral growth factors, it seems wise to include the hypervascular halo in the intended-to-treat volume

  11. Dose-volume histogram parameters of high-dose-rate brachytherapy for Stage I-II cervical cancer (≤4cm) arising from a small-sized uterus treated with a point A dose-reduced plan.

    PubMed

    Nakagawa, Akiko; Ohno, Tatsuya; Noda, Shin-ei; Kubo, Nobuteru; Kuwako, Keiko; Saitoh, Jun-Ichi; Nakano, Takashi

    2014-07-01

    We investigated the rectal dose-sparing effect and tumor control of a point A dose-reduced plan in patients with Stage I-II cervical cancer (≤4 cm) arising from a small-sized uterus. Between October 2008 and August 2011, 19 patients with Stage I-II cervical cancer (≤4 cm) were treated with external beam radiotherapy (EBRT) for the pelvis and CT-guided brachytherapy. Seven patients were treated with brachytherapy with standard loading of source-dwell positions and a fraction dose of 6 Gy at point A (conventional brachy-plan). The other 12 patients with a small uterus close to the rectum or small intestine were treated with brachytherapy with a point A dose-reduction to match D2cc of the rectum and <6 Gy as the dose constraint ('point A dose-reduced plan') instead of the 6-Gy plan at point A ('tentative 6-Gy plan'). The total doses from EBRT and brachytherapy were added up and normalized to a biological equivalent dose of 2 Gy per fraction (EQD2). The median doses to the high-risk clinical target volume (HR-CTV) D90 in the conventional brachy-plan, tentative 6-Gy plan and point A dose-reduced plan were 62 GyEQD2, 80 GyEQD2 and 64 GyEQD2, respectively. The median doses of rectal D2cc in the corresponding three plans were 42 GyEQD2, 62 GyEQD2 and 51 GyEQD2, respectively. With a median follow-up period of 35 months, three patients developed Grade-1 late rectal complications and no patients developed local recurrence. Our preliminary results suggested that CT-guided brachytherapy using an individualized point A dose-reduced plan might be useful for reducing late rectal complications while maintaining primary tumor control.

  12. Value of three-dimensional volume rendering images in the assessment of the centrality index for preoperative planning in patients with renal masses.

    PubMed

    Sofia, C; Magno, C; Silipigni, S; Cantisani, V; Mucciardi, G; Sottile, F; Inferrera, A; Mazziotti, S; Ascenti, G

    2017-01-01

    To evaluate the precision of the centrality index (CI) measurement on three-dimensional (3D) volume rendering technique (VRT) images in patients with renal masses, compared to its standard measurement on axial images. Sixty-five patients with renal lesions underwent contrast-enhanced multidetector (MD) computed tomography (CT) for preoperative imaging. Two readers calculated the CI on two-dimensional axial images and on VRT images, measuring it in the plane that the tumour and centre of the kidney were lying in. Correlation and agreement of interobserver measurements and inter-method results were calculated using intraclass correlation (ICC) coefficients and the Bland-Altman method. Time saving was also calculated. The correlation coefficients were r=0.99 (p<0.05) and r=0.99 (p<0.05) for both the CI on axial and VRT images, with an ICC of 0.99, and 0.99, respectively. Correlation between the two methods of measuring the CI on VRT and axial CT images was r=0.99 (p<0.05). The two methods showed a mean difference of -0.03 (SD 0.13). Mean time saving per each examination with VRT was 45.5%. The present study showed that VRT and axial images produce almost identical values of CI, with the advantages of greater ease of execution and a time saving of almost 50% for 3D VRT images. In addition, VRT provides an integrated perspective that can better assist surgeons in clinical decision making and in operative planning, suggesting this technique as a possible standard method for CI measurement. Copyright © 2016 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

  13. A phase II comparative study of gross tumor volume definition with or without PET/CT fusion in dosimetric planning for non-small-cell lung cancer (NSCLC): primary analysis of Radiation Therapy Oncology Group (RTOG) 0515.

    PubMed

    Bradley, Jeffrey; Bae, Kyounghwa; Choi, Noah; Forster, Ken; Siegel, Barry A; Brunetti, Jacqueline; Purdy, James; Faria, Sergio; Vu, Toni; Thorstad, Wade; Choy, Hak

    2012-01-01

    Radiation Therapy Oncology Group (RTOG) 0515 is a Phase II prospective trial designed to quantify the impact of positron emission tomography (PET)/computed tomography (CT) compared with CT alone on radiation treatment plans (RTPs) and to determine the rate of elective nodal failure for PET/CT-derived volumes. Each enrolled patient underwent definitive radiation therapy for non-small-cell lung cancer (≥ 60 Gy) and had two RTP datasets generated: gross tumor volume (GTV) derived with CT alone and with PET/CT. Patients received treatment using the PET/CT-derived plan. The primary end point, the impact of PET/CT fusion on treatment plans was measured by differences of the following variables for each patient: GTV, number of involved nodes, nodal station, mean lung dose (MLD), volume of lung exceeding 20 Gy (V20), and mean esophageal dose (MED). Regional failure rate was a secondary end point. The nonparametric Wilcoxon matched-pairs signed-ranks test was used with Bonferroni adjustment for an overall significance level of 0.05. RTOG 0515 accrued 52 patients, 47 of whom are evaluable. The follow-up time for all patients is 12.9 months (2.7-22.2). Tumor staging was as follows: II = 6%; IIIA = 40%; and IIIB = 54%. The GTV was statistically significantly smaller for PET/CT-derived volumes (98.7 vs. 86.2 mL; p < 0.0001). MLDs for PET/CT plans were slightly lower (19 vs. 17.8 Gy; p = 0.06). There was no significant difference in the number of involved nodes (2.1 vs. 2.4), V20 (32% vs. 30.8%), or MED (28.7 vs. 27.1 Gy). Nodal contours were altered by PET/CT for 51% of patients. One patient (2%) has developed an elective nodal failure. PET/CT-derived tumor volumes were smaller than those derived by CT alone. PET/CT changed nodal GTV contours in 51% of patients. The elective nodal failure rate for GTVs derived by PET/CT is quite low, supporting the RTOG standard of limiting the target volume to the primary tumor and involved nodes. Copyright © 2012 Elsevier Inc. All rights

  14. A Phase II Comparative Study of Gross Tumor Volume Definition With or Without PET/CT Fusion in Dosimetric Planning for Non-Small-Cell Lung Cancer (NSCLC): Primary Analysis of Radiation Therapy Oncology Group (RTOG) 0515

    SciTech Connect

    Bradley, Jeffrey; Bae, Kyounghwa; Choi, Noah; Forster, Ken; Siegel, Barry A.; Brunetti, Jacqueline; Purdy, James; Faria, Sergio; Vu, Toni; Thorstad, Wade; Choy, Hak

    2012-01-01

    Background: Radiation Therapy Oncology Group (RTOG) 0515 is a Phase II prospective trial designed to quantify the impact of positron emission tomography (PET)/computed tomography (CT) compared with CT alone on radiation treatment plans (RTPs) and to determine the rate of elective nodal failure for PET/CT-derived volumes. Methods: Each enrolled patient underwent definitive radiation therapy for non-small-cell lung cancer ({>=}60 Gy) and had two RTP datasets generated: gross tumor volume (GTV) derived with CT alone and with PET/CT. Patients received treatment using the PET/CT-derived plan. The primary end point, the impact of PET/CT fusion on treatment plans was measured by differences of the following variables for each patient: GTV, number of involved nodes, nodal station, mean lung dose (MLD), volume of lung exceeding 20 Gy (V20), and mean esophageal dose (MED). Regional failure rate was a secondary end point. The nonparametric Wilcoxon matched-pairs signed-ranks test was used with Bonferroni adjustment for an overall significance level of 0.05. Results: RTOG 0515 accrued 52 patients, 47 of whom are evaluable. The follow-up time for all patients is 12.9 months (2.7-22.2). Tumor staging was as follows: II = 6%; IIIA = 40%; and IIIB = 54%. The GTV was statistically significantly smaller for PET/CT-derived volumes (98.7 vs. 86.2 mL; p < 0.0001). MLDs for PET/CT plans were slightly lower (19 vs. 17.8 Gy; p = 0.06). There was no significant difference in the number of involved nodes (2.1 vs. 2.4), V20 (32% vs. 30.8%), or MED (28.7 vs. 27.1 Gy). Nodal contours were altered by PET/CT for 51% of patients. One patient (2%) has developed an elective nodal failure. Conclusions: PET/CT-derived tumor volumes were smaller than those derived by CT alone. PET/CT changed nodal GTV contours in 51% of patients. The elective nodal failure rate for GTVs derived by PET/CT is quite low, supporting the RTOG standard of limiting the target volume to the primary tumor and involved nodes.

  15. Automatic segmentation of the clinical target volume and organs at risk in the planning CT for rectal cancer using deep dilated convolutional neural networks.

    PubMed

    Men, Kuo; Dai, Jianrong; Li, Yexiong

    2017-09-30

    Delineation of the clinical target volume (CTV) and organs at risk (OARs) is very important for radiotherapy but is time-consuming and prone to inter-observer variation. Here, we proposed a novel deep dilated convolutional neural network (DDCNN)-based method for fast and consistent auto-segmentation of these structures. Our DDCNN method was an end-to-end architecture enabling fast training and testing. Specifically, it employed a novel multiple-scale convolutional architecture to extract multiple-scale context features in the early layers, which contain the original information on fine texture and boundaries and which are very useful for accurate auto-segmentation. In addition, it enlarged the receptive fields of dilated convolutions at the end of networks to capture complementary context features. Then, it replaced the fully connected layers with fully convolutional layers to achieve pixel-wise segmentation. We used data from 278 patients with rectal cancer for evaluation. The CTV and OARs were delineated and validated by senior radiation oncologists in the planning computed tomography (CT) images. A total of 218 patients chosen randomly were used for training, and the remaining 60 for validation. The Dice similarity coefficient (DSC) was used to measure segmentation accuracy. Performance was evaluated on segmentation of the CTV and OARs. In addition, the performance of DDCNN was compared with that of U-Net. The proposed DDCNN method outperformed the U-Net for all segmentations, and the average DSC value of DDCNN was 3.8% higher than that of U-Net. Mean DSC values of DDCNN were 87.7% for the CTV, 93.4% for the bladder, 92.1% for the left femoral head, 92.3% for the right femoral head, 65.3% for the intestine and 61.8% for the colon. The test time was 45 s per patient for segmentation of all the CTV, bladder, left and right femoral heads, colon and intestine. We also assessed our approaches and results with those in the literature: our system showed superior

  16. SU-E-T-364: Estimating the Minimum Number of Patients Required to Estimate the Required Planning Target Volume Margins for Prostate Glands

    SciTech Connect

    Bakhtiari, M; Schmitt, J; Sarfaraz, M; Osik, C

    2015-06-15

    Purpose: To establish a minimum number of patients required to obtain statistically accurate Planning Target Volume (PTV) margins for prostate Intensity Modulated Radiation Therapy (IMRT). Methods: A total of 320 prostate patients, consisting of a total number of 9311 daily setups, were analyzed. These patients had gone under IMRT treatments. Daily localization was done using the skin marks and the proper shifts were determined by the CBCT to match the prostate gland. The Van Herk formalism is used to obtain the margins using the systematic and random setup variations. The total patient population was divided into different grouping sizes varying from 1 group of 320 patients to 64 groups of 5 patients. Each grouping was used to determine the average PTV margin and its associated standard deviation. Results: Analyzing all 320 patients lead to an average Superior-Inferior margin of 1.15 cm. The grouping with 10 patients per group (32 groups) resulted to an average PTV margin between 0.6–1.7 cm with the mean value of 1.09 cm and a standard deviation (STD) of 0.30 cm. As the number of patients in groups increases the mean value of average margin between groups tends to converge to the true average PTV of 1.15 cm and STD decreases. For groups of 20, 64, and 160 patients a Superior-Inferior margin of 1.12, 1.14, and 1.16 cm with STD of 0.22, 0.11, and 0.01 cm were found, respectively. Similar tendency was observed for Left-Right and Anterior-Posterior margins. Conclusion: The estimation of the required margin for PTV strongly depends on the number of patients studied. According to this study at least ∼60 patients are needed to calculate a statistically acceptable PTV margin for a criterion of STD < 0.1 cm. Numbers greater than ∼60 patients do little to increase the accuracy of the PTV margin estimation.

  17. TH-E-BRE-03: A Novel Method to Account for Ion Chamber Volume Averaging Effect in a Commercial Treatment Planning System Through Convolution

    SciTech Connect

    Barraclough, B; Li, J; Liu, C; Yan, G

    2014-06-15

    Purpose: Fourier-based deconvolution approaches used to eliminate ion chamber volume averaging effect (VAE) suffer from measurement noise. This work aims to investigate a novel method to account for ion chamber VAE through convolution in a commercial treatment planning system (TPS). Methods: Beam profiles of various field sizes and depths of an Elekta Synergy were collected with a finite size ion chamber (CC13) to derive a clinically acceptable beam model for a commercial TPS (Pinnacle{sup 3}), following the vendor-recommended modeling process. The TPS-calculated profiles were then externally convolved with a Gaussian function representing the chamber (σ = chamber radius). The agreement between the convolved profiles and measured profiles was evaluated with a one dimensional Gamma analysis (1%/1mm) as an objective function for optimization. TPS beam model parameters for focal and extra-focal sources were optimized and loaded back into the TPS for new calculation. This process was repeated until the objective function converged using a Simplex optimization method. Planar dose of 30 IMRT beams were calculated with both the clinical and the re-optimized beam models and compared with MapCHEC™ measurements to evaluate the new beam model. Results: After re-optimization, the two orthogonal source sizes for the focal source reduced from 0.20/0.16 cm to 0.01/0.01 cm, which were the minimal allowed values in Pinnacle. No significant change in the parameters for the extra-focal source was observed. With the re-optimized beam model, average Gamma passing rate for the 30 IMRT beams increased from 92.1% to 99.5% with a 3%/3mm criterion and from 82.6% to 97.2% with a 2%/2mm criterion. Conclusion: We proposed a novel method to account for ion chamber VAE in a commercial TPS through convolution. The reoptimized beam model, with VAE accounted for through a reliable and easy-to-implement convolution and optimization approach, outperforms the original beam model in standard IMRT QA

  18. Dose–volume histogram parameters of high-dose-rate brachytherapy for Stage I–II cervical cancer (≤4cm) arising from a small-sized uterus treated with a point A dose-reduced plan

    PubMed Central

    Nakagawa, Akiko; Ohno, Tatsuya; Noda, Shin-ei; Kubo, Nobuteru; Kuwako, Keiko; Saitoh, Jun-ichi; Nakano, Takashi

    2014-01-01

    We investigated the rectal dose-sparing effect and tumor control of a point A dose-reduced plan in patients with Stage I–II cervical cancer (≤4 cm) arising from a small-sized uterus. Between October 2008 and August 2011, 19 patients with Stage I–II cervical cancer (≤4 cm) were treated with external beam radiotherapy (EBRT) for the pelvis and CT-guided brachytherapy. Seven patients were treated with brachytherapy with standard loading of source-dwell positions and a fraction dose of 6 Gy at point A (conventional brachy-plan). The other 12 patients with a small uterus close to the rectum or small intestine were treated with brachytherapy with a point A dose-reduction to match D2cc of the rectum and <6 Gy as the dose constraint (‘point A dose-reduced plan’) instead of the 6-Gy plan at point A (‘tentative 6-Gy plan’). The total doses from EBRT and brachytherapy were added up and normalized to a biological equivalent dose of 2 Gy per fraction (EQD2). The median doses to the high-risk clinical target volume (HR-CTV) D90 in the conventional brachy-plan, tentative 6-Gy plan and point A dose-reduced plan were 62 GyEQD2, 80 GyEQD2 and 64 GyEQD2, respectively. The median doses of rectal D2cc in the corresponding three plans were 42 GyEQD2, 62 GyEQD2 and 51 GyEQD2, respectively. With a median follow-up period of 35 months, three patients developed Grade-1 late rectal complications and no patients developed local recurrence. Our preliminary results suggested that CT-guided brachytherapy using an individualized point A dose-reduced plan might be useful for reducing late rectal complications while maintaining primary tumor control. PMID:24566721

  19. Educational Planning in the Context of Current Development Problems. An IIEP Seminar (Paris, France, October 3-8, 1983). Volume I.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). International Inst. for Educational Planning.

    The International Institute for Educational Planning (IIEP) selected three areas of inquiry as its focal concerns for the years 1984-1989. The first of these centered on the influences on each other of education and technological development, and on the implications of these mutual influences for educational planning on a national scale,…

  20. The 25 kW power module evolution study. Part 3: Conceptual designs for power module evolution. Volume 2: Program plans

    NASA Technical Reports Server (NTRS)

    1979-01-01

    A plan is presented for the evolutionary development and deployment of the power module system with performance capabilities required to support the 1983 to 1990 user requirements. Aspects summarized include program functional, operational, and hardware elements; program work breakdown and specification items; development plans and schedules for developmental and technology milestones; test concepts and timeliness; and ground and orbit operations concepts.

  1. Advanced space system concepts and their orbital support needs (1980 - 2000). Volume 4: Detailed data. Part 2: Program plans and common support needs (a study of the commonality of space vehicle applications to future national needs

    NASA Technical Reports Server (NTRS)

    Bekey, I.; Mayer, H. L.; Wolfe, M. G.

    1976-01-01

    The methodology of alternate world future scenarios is utilized for selecting a plausible, though not advocated, set of future scenarios each of which results in a program plan appropriate for the respective environment. Each such program plan gives rise to different building block and technology requirements, which are analyzed for common need between the NASA and the DoD for each of the alternate world scenarios. An essentially invariant set of system, building block, and technology development plans is presented at the conclusion, intended to allow protection of most of the options for system concepts regardless of what the actual future world environment turns out to be. Thus, building block and technology needs are derived which support: (1) each specific world scenario; (2) all the world scenarios identified in this study; or (3) generalized scenarios applicable to almost any future environment. The output included in this volume consists of the building blocks, i.e.: transportation vehicles, orbital support vehicles, and orbital support facilities; the technology required to support the program plans; identification of their features which could support the DoD and NASA in common; and a complete discussion of the planning methodology.

  2. Program plan for the DOE Office of Fusion Energy First Wall/Blanket/Shield Engineering Technology Program. Volume I. Summary, objectives and management. Revision 2

    SciTech Connect

    Not Available

    1982-08-01

    This document defines a plan for conducting selected aspects of the engineering testing required for magnetic fusion reactor FWBS components and systems. The ultimate product of this program is an established data base that contributes to a functional, reliable, maintainable, economically attractive, and environmentally acceptable commercial fusion reactor first wall, blanket, and shield system. This program plan updates the initial plan issued in November of 1980 by the DOE/Office of Fusion Energy (unnumbered report). The plan consists of two parts. Part I is a summary of activities, responsibilities and program management including reporting and interfaces with other programs. Part II is a compilation of the Detailed Technical Plans for Phase I (1982 to 1984) developed by the participants during Phase 0 of the program (July to December 1981).

  3. Formulation of detailed consumables management models for the development (preoperational) period of advanced space transportation system. Volume 1: Detailed requirements for the mission planning processor

    NASA Technical Reports Server (NTRS)

    Connelly, L. C.

    1976-01-01

    Detailed requirements for the mission planning processor are documented. The mission planning processor is a user oriented tool for consumables management and is part of the total consumables subsystem management concept. A quasi top-down approach was applied to the design of the mission planning processor. Interface requirements, input/output, and data base concepts were considered before computational processing. Existing analytical models were investigated for applicability before new models were developed. The mission planning processor was designed for an interactive system using demand terminals for input/outputdisplay and interfacing with an updateable mission data bank. The control and support routines provide the user interface, peripheral data handling, program control, and support functions required by the mission planning processor for execution on an interactive system. A description, interface requirements, definition of internal variables, listing of input data, processing flow diagram, and listing of output data are presented for each routine.

  4. Space transfer concepts and analysis for exploration missions. Implementation plan and element description document. Volume 1: Major trades. Book 1: Draft final

    NASA Technical Reports Server (NTRS)

    1991-01-01

    This document presents trade studies and reference concept designs accomplished during a study of Space Transfer Concepts and Analyses for Exploration Missions (STCAEM). This volume contains the major top level trades, level 2 trades conducted in support of NASA's Lunar/Mars Exploration Program Office, and a synopsis of the vehicles for different propulsion systems under trade consideration. The vehicles are presented in more detail in other volumes of this report. Book 1 of Volume 1 covers the following analyses: lunar/Mars commonality trades, lunar/Mars mission operations, and Mars transfer systems.

  5. Power Extension Package (PEP) system definition extension, orbital service module systems analysis study. Volume 9: PEP design, development and test plans

    NASA Technical Reports Server (NTRS)

    1979-01-01

    A plan for the production of two PEP flight systems is defined. The task's milestones are described. Provisions for the development and assembly of new ground support equipment required for both testing and launch operations are included.

  6. Use of Virtual Surgical Planning for Simultaneous Maxillofacial Osteotomies and Custom Polyetheretherketone Implant in Secondary Orbito-Frontal Reconstruction: Importance of Restoring Orbital Volume.

    PubMed

    Patel, Neel; Kim, Beomjune; Zaid, Waleed

    2017-03-01

    Correction of orbito-frontal defects involves a multitude of surgical challenges, and requires careful and detailed planning. In the trauma setting, one must be prepared to deal with injuries to adjacent structures and be able to incorporate their repair into the surgical plan to maximize the functional and esthetic reconstruction for the benefit of the patient. Victims who have sustained trauma of the cranial complex in combination with mid-facial trauma, particularly involving the orbit, present a difficult scenario, especially when future ocular prosthetic rehabilitation is a concern. The authors present a patient of virtual surgical planning-guided planning of mid-facial osteotomies and custom implant creation for the secondary reconstruction of a patient who sustained extensive orbito-frontal trauma, requiring not only cranial vault recontouring, but also reconstruction of the mid-facial and orbital complex to accommodate an ocular prosthesis that would demonstrate proper anatomical relationships to maximize esthetics and function.

  7. Integrated Hatchery Operations Team: Operations Plans for Anadromous Fish Production Facilities in the Columbia River Basin, Volume IV of V; 1992 Annual Report.

    SciTech Connect

    Peck, Larry

    1993-04-01

    Operational plans for Cowlitz, Elokomin, Grays River, Kalama Falls, Lewis River and Speelyai, Lower Kalama, Lyons Ferry, Methow, Priest Rapids, Ringold Springs, Rock Island, Toutle, Washougal, and Wells Salmon Hatcheries are individually described.

  8. Adapting and Testing Business Management Development Programs for Educational Administrators. Volume 6 of 6 Volumes. Appendix J-Evaluation Report, Maxwell School. Appendix K-Schematic of Planning Process and Narrative Description. Appendix L-Narrative Description. Final Report.

    ERIC Educational Resources Information Center

    Klawuhn, Raymond E.; Basso, Alexander J.

    This report constitutes an evaluation of the first year of a 2-year training program conducted by the American Management Association. The program focuses on organizational planning in two State educational agencies and involves the sequential implementation of three distinct, offsite, residential training efforts. The first of these, the…

  9. Popliteal-to-Dorsalis Pedis In-Situ Small Saphenous Vein Bypass under Planning with Mapping Using Computed Tomography Volume Rendering Technique.

    PubMed

    Byun, Seung-Jae

    2015-09-01

    The small saphenous vein (SSV) is an important graft in limb salvage surgery. It is frequently translocated for bypass surgery. Sometimes, the use of the SSV as an in-situ graft for posterior tibial artery or peroneal artery reconstruction offers the advantages of reduced vein graft injury and improved patency. Recently, saphenous vein mapping through computed tomography (CT) volume rendering technique offers a great quality view to the surgeon. We experienced a patient in whom a CT image with volume rendering technique revealed an aberrant SSV connected with the great saphenous vein at the medial malleolus level. This case indicates that an aberrant SSV may be successfully used as an in-situ conduit for bypass to the dorsalis pedis artery. Here, we present the case of a popliteal-to-dorsalis pedis in-situ vein bypass using a LeMaitre valvulotome (LeMaitre Vascular Inc., USA) under mapping of the aberrant SSV by CT volume rendering technique.

  10. Delineation of Gross Tumor Volume (GTV) for Radiation Treatment Planning of Locally Advanced Rectal Cancer Using Information From MRI or FDG-PET/CT: A Prospective Study

    SciTech Connect

    Braendengen, Morten; Hansson, Karl; Radu, Calin; Siegbahn, Albert; Jacobsson, Hans; Glimelius, Bengt

    2011-11-15

    Purpose: Accurate delineation of target volumes is important to maximize radiation dose to the tumor and minimize it to nontumor tissue. Computed tomography (CT) and magnetic resonance imaging (MRI) are standard imaging modalities in rectal cancer. The aim was to explore whether functional imaging with F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET), combined with CT (FDG-PET/CT) gives additional information to standard pretreatment evaluation and changes the shape and size of the gross tumor volume (GTV). Methods and Materials: From 2007 to 2009, 77 consecutive patients with locally advanced rectal cancer were prospectively screened for inclusion in the study at two university hospitals in Sweden, and 68 patients were eligible. Standard GTV was delineated using information from clinical examination, CT, and MRI (GTV-MRI). Thereafter, a GTV-PET was defined in the fused PET-CT, and the target volume delineations were compared for total volume, overlap, and mismatch. Pathologic uptake suspect of metastases was also registered. Results: The median volume of GTV-MRI was larger than that of GTV-PET: 111 cm{sup 3} vs. 87 cm{sup 3} (p < 0.001). In many cases, the GTV-MRI contained the GTV defined on the PET/CT images as subvolumes, but when a GTV total was calculated after the addition of GTV-PET to GTV-MRI, the volume increased, with median 11% (range, 0.5-72%). New lesions were seen in 15% of the patients for whom PET/CT was used. Conclusions: FDG-PET/CT facilitates and adds important information to the standard delineation procedure of locally advanced rectal cancer, mostly resulting in a smaller GTV, but a larger total GTV using the union of GTV-MRI and GTV-PET. New lesions were sometimes seen, potentially changing the treatment strategy.

  11. Site characterization plan: Yucca Mountain Site, Nevada Research and Development Area, Nevada: Volume 2, Part A: Chapters 3, 4, and 5

    SciTech Connect

    1988-12-01

    This site characterization plan (SCP) has been developed for the candidate repository site at Yucca Mountain in the State of Nevada. The SCP includes a description of the Yucca Mountain site (Chapters 1--5), a conceptual design for the repository (Chapter 6), a description of the packaging to be used for the waste to be emplaced in the repository (Chapter 7), and a description of the planned site characterization activities (Chapter 8). The schedules and milestones presented in Sections 8.3 and 8.5 of the SCP were developed to be consistent with the June 1988 draft Amendment to the DOE`s Mission Plan for the Civilian Radioactive Waste Management Program. The five month delay in the scheduled start of exploratory shaft construction that was announced recently is not reflected in these schedules. 575 refs., 84 figs., 68 tabs.

  12. Site characterization plan: Yucca Mountain Site, Nevada Research and Development Area, Nevada: Volume 4, Part B: Chapter 8, Sections 8.0 through 8.3.1.4

    SciTech Connect

    1988-12-01

    This site characterization plan (SCP) has been developed for the candidate repository site at Yucca Mountain in the State of Nevada. The SCP includes a description of the Yucca Mountain site (Chapters 1-5), a conceptual design for the repository (Chapter 6), a description of the packaging to be used for the waste to be emplaced in the repository (Chapter 7), and a description of the planned site characterization activities (Chapter 8). The schedules and milestones presented in Sections 8.3 and 8.5 of the SCP were developed to be consistent with the June 1988 draft Amendment to the DOE`s Mission Plan for the Civilian Radioactive Waste Management Program. The five month delay in the scheduled start of exploratory shaft construction that was announced recently is not reflected in these schedules. 74 figs., 32 tabs.

  13. Investigation Development Plan for Reflight of the Small Helium-cooled Infrared Telescope Experiment. Volume 1: Investigation and Technical/management

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The Infrared Telescope (IRT) is designed to survey extended celestial sources of infrared radiation between 4 and 120 micrometers wavelength. It will provide data regarding Space Shuttle induced environmental contamination and the zodical light. And, it will provide experience in the management of large volumes of superfluid helium in the space environment.

  14. Making A Difference: What Communities Can Do To Prevent Mental Handicap and Promote Lives of Quality. Volume I: Planning for Change.

    ERIC Educational Resources Information Center

    Kappel, Bruce

    The first of five volumes on the means by which Canadian communities can reduce the incidence of mental retardation, minimize existing impairment, and improve the quality of life of the mentally retarded, this booklet provides an overview of the types of conditions leading to mental handicap and what can be done to prevent or ameliorate those…

  15. Making A Difference: What Communities Can Do To Prevent Mental Handicap and Promote Lives of Quality. Volume I: Planning for Change.

    ERIC Educational Resources Information Center

    Kappel, Bruce

    The first of five volumes on the means by which Canadian communities can reduce the incidence of mental retardation, minimize existing impairment, and improve the quality of life of the mentally retarded, this booklet provides an overview of the types of conditions leading to mental handicap and what can be done to prevent or ameliorate those…

  16. Power Extension Package (PEP) system definition extension, orbital service module systems analysis study. Volume 7: PEP logistics and training plan requirements

    NASA Technical Reports Server (NTRS)

    1979-01-01

    Recommendations for logistics activities and logistics planning are presented based on the assumption that a system prime contractor will perform logistics functions to support all program hardware and will implement a logistics system to include the planning and provision of products and services to assure cost effective coverage of the following: maintainability; maintenance; spares and supply support; fuels; pressurants and fluids; operations and maintenance documentation training; preservation, packaging and packing; transportation and handling; storage; and logistics management information reporting. The training courses, manpower, materials, and training aids required will be identified and implemented in a training program.

  17. Atmospheric, Magnetospheric and Plasmas in Space (AMPS) spacelab payload definition study - program analysis and planning for phase C/D document - Volume 7

    NASA Technical Reports Server (NTRS)

    Keeley, J. T.

    1976-01-01

    Typical missions identified for AMPS flights in the arly 1980's are described. Experiment objectives and typical scientific instruments selected to accomplish these objectives are discussed along with mission requirements and shuttle and Spacelab capabilities assessed to determine any AMPS unique requirements. Preliminary design concepts for the first two AMPS flights form the basis for the Phase C/D program plan. This plan implements flights 1 and 2 and indicates how both the scientific and flight support hardware can be systematically evolved for future AMPS flights.

  18. Space station MSFC-DPD-235/DR no. MA-05 phase C/D program development plan. Volume 2: Phase C/D, programmatic requirements

    NASA Technical Reports Server (NTRS)

    1971-01-01

    The design plan requirements define the design implementation and control requirements for Phase C/D of the Modular Space Station Project and specifically address the Initial Space Station phase of the Space Station Program (modular). It is based primarily on the specific objective of translating the requirements of the Space Station Program, Project, Interface, and Support Requirements and preliminary contract end x item specifications into detail design of the operational systems which comprise the initial space station. This document is designed to guide aerospace contractors in the planning and bidding for Phase C/D.

  19. Restoration of bighorn sheep metapopulations in and near 15 national parks: Conservation of a severely fragmented species; Volume I, Planning, problem definition, findings, and restoration

    USGS Publications Warehouse

    Singer, Francis J.; Gudorf, Michelle A.

    1999-01-01

    This report details the 7-year restoration of bighorn sheep to all currently suitable historic habitats in the national parks of the former Rocky Mountain Region (now the Intermountain and Midwest regions of the National Park Service). The purpose of the first phase of the restoration during 1991-93 was to conduct research and population surveys and to formulate the restoration plans. The purpose of the second phase of the initiative during 1994-97 was to conduct GIS-based habitat and biological assessments of prospective restoration sites, write restoration plans, and restore and monitor the released bighorn sheep.

  20. Usefulness of double dose contrast-enhanced magnetic resonance imaging for clear delineation of gross tumor volume in stereotactic radiotherapy treatment planning of metastatic brain tumors: a dose comparison study.

    PubMed

    Subedi, Kalloo Sharma; Takahashi, Takeo; Yamano, Takafumi; Saitoh, Jun-ichi; Nishimura, Keiichiro; Suzuki, Yoshiyuki; Ohno, Tatsuya; Nakano, Takashi

    2013-01-01

    The purpose of this study was to compare the size and clearness of gross tumor volumes (GTVs) of metastatic brain tumors on T1-weighted magnetic resonance images between a single dose contrast administration protocol and a double dose contrast administration protocol to determine the optimum dose of contrast-enhancement for clear delineation of GTV in stereotactic radiotherapy (SRT). A total of 28 small metastatic brain tumors were evaluated in 13 patients by intra-individual comparison of GTV measurements using single dose and double dose contrast-enhanced thin-slice (1-mm) magnetic resonance imaging (MRI). All patients had confirmed histological types of primary tumors and had undergone hypo-fractionated SRT for metastatic brain tumors. The mean tumor diameter with single dose and double dose contrast-enhancement was 12.0 ± 1.1 mm and 13.2 ± 1.1 mm respectively (P < 0.001). The mean incremental ratio (MIR) obtained by comparing mean tumor diameters was 11.2 ± 0.02 %. The mean volume of GTV-1 (single dose contrast-enhancement) and GTV-2 (double dose contrast-enhancement) was 1.38 ± 0.41 ml and 1.59 ± 0.45 ml respectively (P < 0.01). The MIR by comparing mean tumor volumes was 32.3 ± 0.4 %. The MIR of GTV-1 with < 1 ml volume and GTV-1 with > 1 ml volume was 41.8 ± 0.05 % and 12.4 ± 0.03 % respectively (P < 0.001). We conclude that double dose contrast-enhanced thin-slice MRI is a more useful technique than single dose contrast-enhanced thin-slice MRI, especially for clear delineation of GTVs of small metastatic brain tumors in treatment planning of highly precise SRT.

  1. Stone volume is best predictor of operative time required in retrograde intrarenal surgery for renal calculi: implications for surgical planning and quality improvement.

    PubMed

    Sorokin, Igor; Cardona-Grau, Diana K; Rehfuss, Alexandra; Birney, Alan; Stavrakis, Costas; Leinwand, Gabriel; Herr, Allen; Feustel, Paul J; White, Mark D

    2016-11-01

    Retrograde intrarenal surgery (RIRS) is highly successful at eliminating renal stones of various sizes and compositions. As urologists are taking on more complex procedures using RIRS, this has led to an increase in operative (OR) times. Our objective was to determine the best predictor of OR time in patients undergoing RIRS. We retrospectively reviewed the records of patients undergoing unilateral RIRS for solitary stones over a 10 year time span. Stones were fragmented and actively extracted using a basket. Variables potentially affecting OR time such as patient age, sex, BMI, lower pole stone location, volume, Hounsfield units (HU), composition, ureteral access sheath (UAS) use, and pre-operative stenting were collected. Multivariable linear and stepwise regression was used to evaluate the predictors of OR time. There were 118 patients that met inclusion criteria. The median stone volume was 282.6 mm(3) (IQR 150.7-644.7) and the mean OR time was 50 min (±25.9 SD). On univariate linear regression, stone volume had a moderate correlation with OR time (y = 0.022x + 38.2, r (2) = 0.363, p < 0.01). On multivariable stepwise regression, stone volume had the strongest impact on OR time, increasing time by 2.0 min for each 100 mm(3) increase in stone volume (p < 0.001). UAS added 13.5 (SE 3.9, p = 0.001) minutes and renal lower pole location added 9 min (SE 4.3, p = 0.03) in each case they were used. Pre-operative stenting, HU, calcium oxalate stone composition, sex, and age had no significant effect on OR time. Amongst the main stone factors in RIRS, stone volume has the strongest impact on operative time. This can be used to predict the length of the procedure by roughly adding 2 min per 100 mm(3) increase in stone volume.

  2. Remedial action plan and site conceptual design for stabilization of the inactive uranium mill tailings site at Ambrosia Lake, New Mexico. Volume 3, Appendix F, Final plans and specifications: Final report

    SciTech Connect

    Not Available

    1991-11-01

    This volume deals with the main construction subcontract for the uranium mill tailings remedial action of Ambrosia Lake, New Mexico. Contents of subcontract documents AMB-4 include: bidding requirements; terms and conditions; specifications which cover general requirements and sitework; and subcontract drawings.

  3. Preliminary design study of advanced composite blade and hub and nonmechanical control system for the tilt-rotor aircraft. Volume 2: Project planning data

    NASA Technical Reports Server (NTRS)

    1980-01-01

    Project planning data for a rotor and control system procurement and testing program for modifications to the XV-15 tilt-rotor research demonstrator aircraft is presented. The design, fabrication, and installation of advanced composite blades compatible with the existing hub, an advanced composite hub, and a nonmechanical control system are required.

  4. Shaping a National Urban Agenda. The Role of the Association of Collegiate Schools of Planning. Subcommittee Report on a National Urban Policy. CAAS Special Publication Volume 9.

    ERIC Educational Resources Information Center

    California Univ., Los Angeles. Afro-American Studies Center.

    A subcommittee of the Association of Collegiate Schools of Planning (ACSP) was charged with the task of developing a national agenda for America's cities and regions. This report consists of the working paper developed by the co-chairs of the subcommittee and the position papers committee members produced. It is intended to be a starting point for…

  5. STS payloads mission control study. Volume 2-A, Task 1: Joint products and functions for preflight planning of flight operations, training and simulations

    NASA Technical Reports Server (NTRS)

    1976-01-01

    Specific products and functions, and associated facility availability, applicable to preflight planning of flight operations were studied. Training and simulation activities involving joint participation of STS and payload operations organizations, are defined. The prelaunch activities required to prepare for the payload flight operations are emphasized.

  6. Planning, Designing, Building, and Moving a Large Volume Maternity Service to a New Labor and Birth Unit: Commentary and Experiences of Experts.

    PubMed

    VonBehren, Diane; Killion, Molly M; Burke, Carol; Finkelmeier, Betsy; Zamora, Brigit

    Three teams of perinatal expert nurses participated in planning and designing a new maternity unit, operationalizing the move to the new space, and evaluating care processes and workflows after the move. The hospitals involved were University of California, San Francisco Benioff Children's Hospital, Prentice Women's Hospital of Northwestern Memorial Healthcare in Chicago, IL, and Florida Hospital Orlando, Florida Hospital for Women. Although each team discussed specific details and lessons learned, there is remarkable consistency among the experiences of these teams and with the discussion of the process by the team at Mercy Hospital St. Louis published in this issue of MCN The American Journal of Maternal Child Nursing. Extensive planning, flexibility, involving key stakeholders, evaluating and simulating workflows, and adequate staffing and patient safety on move-day were reported to be essential to success. Reevaluation after settling in to the new unit and making changes as needed were discussed. Being part of the leadership team involved in planning and moving to a new maternity unit in what was likely a once-in-a-lifetime experience was viewed as a career highlight. Their commentary adds to what is known about planning and designing new maternity units, moving into the new space, and adjusting unit operations and care after making the new unit home.

  7. Atmosphere, Magnetosphere and Plasmas in Space (AMPS). Spacelab payload definition study. Volume 7, book 2: AMPS phase C/D analysis and planning document

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The results are presented of the AMPS Phase C/D (Design, Development, and Operations) program analysis and planning effort. Cost and schedule estimates are included. Although the AMPS program has been specifically addressed, these task descriptions are basically adaptable to a broader-based program incorporating additional or different Spacelab/orbiter payloads.

  8. A plan for application system verification tests: The value of improved meteorological information, volume 1. [economic consequences of improved meteorological information

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The framework within which the Applications Systems Verification Tests (ASVTs) are performed and the economic consequences of improved meteorological information demonstrated is described. This framework considers the impact of improved information on decision processes, the data needs to demonstrate the economic impact of the improved information, the data availability, the methodology for determining and analyzing the collected data and demonstrating the economic impact of the improved information, and the possible methods of data collection. Three ASVTs are considered and program outlines and plans are developed for performing experiments to demonstrate the economic consequences of improved meteorological information. The ASVTs are concerned with the citrus crop in Florida, the cotton crop in Mississippi and a group of diverse crops in Oregon. The program outlines and plans include schedules, manpower estimates and funding requirements.

  9. A state-of-the-art review of transportation systems evaluation techniques relevant to air transportation, volume 1. [urban planning and urban transportation using decision theory

    NASA Technical Reports Server (NTRS)

    Haefner, L. E.

    1975-01-01

    Mathematical and philosophical approaches are presented for evaluation and implementation of ground and air transportation systems. Basic decision processes are examined that are used for cost analyses and planning (i.e, statistical decision theory, linear and dynamic programming, optimization, game theory). The effects on the environment and the community that a transportation system may have are discussed and modelled. Algorithmic structures are examined and selected bibliographic annotations are included. Transportation dynamic models were developed. Citizen participation in transportation projects (i.e, in Maryland and Massachusetts) is discussed. The relevance of the modelling and evaluation approaches to air transportation (i.e, airport planning) is examined in a case study in St. Louis, Missouri.

  10. Design study of RL10 derivatives. Volume 3, part 2: Operational and flight support plan. [analysis of transportation requirements for rocket engine in support of space tug program

    NASA Technical Reports Server (NTRS)

    Shubert, W. C.

    1973-01-01

    Transportation requirements are considered during the engine design layout reviews and maintenance engineering analyses. Where designs cannot be influenced to avoid transportation problems, the transportation representative is advised of the problems permitting remedies early in the program. The transportation representative will monitor and be involved in the shipment of development engine and GSE hardware between FRDC and vehicle manufacturing plant and thereby will be provided an early evaluation of the transportation plans, methods and procedures to be used in the space tug support program. Unanticipated problems discovered in the shipment of development hardware will be known early enough to permit changes in packaging designs and transportation plans before the start of production hardware and engine shipments. All conventional transport media can be used for the movement of space tug engines. However, truck transport is recommended for ready availability, variety of routes, short transit time, and low cost.

  11. Survey Plan For Characterization of the Subsurface Underlying the National Aeronautics and Space Administration's Marshall Space Flight Center in Huntsville, Alabama. Volume 1 and 2

    NASA Technical Reports Server (NTRS)

    1996-01-01

    Topic considered include: survey objectives; technologies for non-Invasive imaging of subsurface; cost; data requirements and sources; climatic condition; hydrology and geology; chemicals; magnetometry; electrical(resistivity, potential); optical-style imaging; reflection/refraction seismics; gravitometry; photo-acoustic activation;well drilling and borehole analysis; comparative assessment matrix; ground sensors; choice of the neutron sources; logistic of operations; system requirements; health and safety plans.

  12. Tracking and data system support for the Pioneer project. Volume 2: Pioneer 11 prelaunch planning through second trajectory correction, to 1 May 1973

    NASA Technical Reports Server (NTRS)

    Barton, W. R.; Miller, R. B.

    1975-01-01

    The tracking and data system support of the planning, testing, launch, near-earth, and deep space phases of the Pioneer 11 Jupiter Mission are described, including critical phases of spacecraft flight and guidance. Scientific instruments aboard the spacecraft registered information relative to interplanetary particles and fields. Knowledge of the celestial mechanics of the solar system was improved through radiometric data gathering. Network performance, details of network support activity, and special support activities are discussed.

  13. Integrated Hatchery Operations Team: Operations Plans for Anadromous Fish Production Facilities in the Columbia River Basin, Volume I of V; 1992 Annual Report.

    SciTech Connect

    Shelldrake, Tom

    1993-08-01

    Individual operational plans for 1993 are provided for the Abernathy Salmon Culture Technology Center, Carson National Fish Hatchery, Dworshak National Fish Hatchery, Eagle Creek National Fish Hatchery, Entiat National Fish Hatchery, Hagerman National Fish Hatchery, Kooskia National Fish Hatchery, Leavenworth National Fish Hatchery, Little White Salmon National Fish Hatchery, Spring Creek National Fish Hatchery, Warm Springs National Fish Hatchery, Willard National Fish Hatchery, and the Winthrop National Fish Hatchery.

  14. Space transfer concepts and analysis for exploration missions. Implementation plan and element description document (draft final). Volume 5: Nuclear electric propulsion vehicle

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The nuclear electric propulsion (NEP) concept design developed in support of the Space Transfer Concepts and Analysis for Exploration Missions (STCAEM) study is presented. The evolution of the NEP concept is described along with the requirements, guidelines, and assumptions for the design. Operating modes and options are defined and a systems description of the vehicle is presented. Artificial gravity configuration options and space and ground support systems are discussed. Finally, an implementation plan is presented which addresses technology needs, schedules, facilities and costs.

  15. Remedial action plan and site design for stabilization of the inactive uranium mill tailings sites at Rifle, Colorado. Volume 2, Appendices D and E: Final report

    SciTech Connect

    Not Available

    1992-02-01

    This appendix assesses the present conditions and data gathered about the two inactive uranium mill tailings sites near Rifle, Colorado, and the designated disposal site six miles north of Rifle in the area of Estes Gulch. It consolidates available engineering, radiological, geotechnical, hydrological, meteorological, and other information pertinent to the design of the Remedial Action Plan (RAP). The data characterize conditions at the mill, tailings, and disposal site so that the Remedial Action Contractor (RAC) may complete final designs for the remedial actions.

  16. Development of Water Resources in Appalachia. Main Report. Part 2. Volume 5a. Sub-Regional Plans. Chapters 13 thru 16

    DTIC Science & Technology

    1969-11-01

    Piney Creek (Kan.) W. Va. Beckley Area 65 Gypsy Hill (Kan.) W. Va. Ronceverte Area (future) 61 Quick Branch - Slack(Kan.) W. Va. Town of Quick 6’ Upper...72,000 a year. The Gypsy Hill Watershed Association has applied for planning and assistance. Extensive studies have been made of the Greenbrier River...included Howard Creek and Gypsy Hill watersheds in Green- brier River Basin. Upper Meadow River, Big Ditch Run, Beaver Creek, Grassy Creek and Cherry

  17. SSTAC/ARTS review of the draft Integrated Technology Plan (ITP). Volume 8: Aerothermodynamics Automation and Robotics (A/R) systems sensors, high-temperature superconductivity

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Viewgraphs of briefings presented at the SSTAC/ARTS review of the draft Integrated Technology Plan (ITP) on aerothermodynamics, automation and robotics systems, sensors, and high-temperature superconductivity are included. Topics covered include: aerothermodynamics; aerobraking; aeroassist flight experiment; entry technology for probes and penetrators; automation and robotics; artificial intelligence; NASA telerobotics program; planetary rover program; science sensor technology; direct detector; submillimeter sensors; laser sensors; passive microwave sensing; active microwave sensing; sensor electronics; sensor optics; coolers and cryogenics; and high temperature superconductivity.

  18. SSTAC/ARTS review of the draft Integrated Technology Plan (ITP). Volume 8: Aerothermodynamics Automation and Robotics (A/R) systems sensors, high-temperature superconductivity

    SciTech Connect

    Not Available

    1991-06-01

    Viewgraphs of briefings presented at the SSTAC/ARTS review of the draft Integrated Technology Plan (ITP) on aerothermodynamics, automation and robotics systems, sensors, and high-temperature superconductivity are included. Topics covered include: aerothermodynamics; aerobraking; aeroassist flight experiment; entry technology for probes and penetrators; automation and robotics; artificial intelligence; NASA telerobotics program; planetary rover program; science sensor technology; direct detector; submillimeter sensors; laser sensors; passive microwave sensing; active microwave sensing; sensor electronics; sensor optics; coolers and cryogenics; and high temperature superconductivity.

  19. Transition projects, Fiscal Year 1996: Multi-Year Program Plan (MYPP) for WBS 1.31, 7.1, and 6.13. Revision 1, Volume 1

    SciTech Connect

    Cartmell, D.B.

    1995-09-01

    Based on US Department of Energy (DOE), Richland Operations Office (RL) review, specific areas of Westinghouse Hanford Company (WHC), Transition Projects ``Draft`` Multi-Year Program Plan (MYPP) were revised in preparation for the RL approval ceremony on September 26, 1995. These changes were reviewed with the appropriate RL Project Manager. The changes have been incorporated to the MYPP electronic file, and hard copies replacing the ``Draft`` MYPP will be distributed after the formal signing. In addition to the comments received, a summary level schedule and outyear estimates for the K Basin deactivation beginning in FY 2001 have been included. The K Basin outyear waste data is nearing completion this week and will be incorporated. This exclusion was discussed with Mr. N.D. Moorer, RL, Facility Transition Program Support/Integration. The attached MYPP scope/schedule reflects the Integrated Target Case submitted in the April 1995 Activity Data Sheets (ADS) with the exception of B Plant and the Plutonium Finishing Plant (PFP). The 8 Plant assumption in FY 1997 reflects the planning case in the FY 1997 ADS with a shortfall of $5 million. PFP assumptions have been revised from the FY 1997 ADS based on the direction provided this past summer by DOE-Headquarters. This includes the acceleration of the polycube stabilization back to its originally planned completion date. Although the overall program repricing in FY 1996 allowed the scheduled acceleration to fall with the funding allocation, the FY 1997 total reflects a shortfall of $6 million.

  20. [Environmental investigation of ground water contamination at Wright-Patterson Air Force Base, Ohio]. Volume 3, Sampling and analysis plan (SAP): Phase 1, Task 4, Field Investigation: Draft

    SciTech Connect

    Not Available

    1991-10-01

    In April 1990, Wright-Patterson Air Force Base (WPAFB), initiated an investigation to evaluate a potential Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) removal action to prevent, to the extent practicable, the offsite migration of contaminated ground water from WPAFB. WPAFB retained the services of the Environmental Management Operations (EMO) and its principle subcontractor, International Technology Corporation (IT) to complete Phase 1 of the environmental investigation of ground-water contamination at WPAFB. Phase 1 of the investigation involves the short-term evaluation and potential design for a program to remove ground-water contamination that appears to be migrating across the western boundary of Area C, and across the northern boundary of Area B along Springfield Pike. Primarily, Task 4 of Phase 1 focuses on collection of information at the Area C and Springfield Pike boundaries of WPAFB. This Sampling and Analysis Plan (SAP) has been prepared to assist in completion of the Task 4 field investigation and is comprised of the Quality Assurance Project Plan (QAPP) and the Field Sampling Plan (FSP).

  1. Guidance for implementing an environmental, safety, and health-assurance program. Volume 15. A model plan for line organization environmental, safety, and health-assurance programs

    SciTech Connect

    Ellingson, A.C.; Trauth, C.A. Jr.

    1982-01-01

    This is 1 of 15 documents designed to illustrate how an Environmental, Safety and Health (ES and H) Assurance Program may be implemented. The generic definition of ES and H Assurance Programs is given in a companion document entitled An Environmental, Safety and Health Assurance Program Standard. This particular document presents a model operational-level ES and H Assurance Program that may be used as a guide by an operational-level organization in developing its own plan. The model presented here reflects the guidance given in the total series of 15 documents.

  2. Space transfer concepts and analysis for exploration missions. Implementation plan and element description document (draft final). Volume 2: Cryo/aerobrake vehicle

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The cryogenic/aerobrake (CAB) and the cryogenic all-propulsive (CAP) concept designs developed in support of the Space Transfer Concepts and Analysis for Exploration Missions (STCAEM) study are presented. The evolution of the CAB and CAP concepts is described along with the requirements, guidelines and assumptions for the designs. Operating modes and options are defined and systems descriptions of the vehicles are presented. Artificial gravity configuration options and space and ground support systems are discussed. Finally, an implementation plan is presented which addresses technology needs, schedules, facilities, and costs.

  3. Space transfer concepts and analysis for exploration missions. Implementation plan and element description document (draft final). Volume 4: Solar electric propulsion vehicle

    NASA Technical Reports Server (NTRS)

    1991-01-01

    This document presents the solar electric propulsion (SEP) concept design developed as part of the Space Transfer Concepts and Analysis for Exploration Missions (STCAEM) study. The evolution of the SEP concept is described along with the requirements, guidelines and assumptions for the design. Operating modes and options are defined and a systems description of the vehicle is presented. Artificial gravity configuration options and space and ground support systems are discussed. Finally, an implementation plan is presented which addresses technology needs, schedules, facilities, and costs.

  4. Remedial Action Plan and final design for stabilization of the inactive uranium mill tailings at Green River, Utah. Volume 1, Text, Appendices A, B, and C: Final report

    SciTech Connect

    Matthews, M.L.; Alkema, K.

    1991-03-01

    This Remedial Action Plan (RAP) has been developed to serve a threefold purpose. It presents the series of activities that are proposed by the US Department of Energy (DOE) to accomplish long-term stabilization and control of radioactive materials at the inactive uranium processing site located near Green River, Utah. It provides a characterization of the present conditions of the site. It also serves to document the concurrence of the state of Utah and the US Nuclear Regulatory Commission (NRC) in the remedial action. This agreement, upon execution by the DOE and the state of Utah, and concurrence by the NRC, becomes Appendix 8 of the Cooperative Agreement.

  5. Space transfer concepts and analysis for exploration missions. Implementation plan and element description document (draft final). Volume 3: Nuclear thermal rocket vehicle

    NASA Technical Reports Server (NTRS)

    1991-01-01

    This document presents the nuclear thermal rocket (NTR) concept design developed in support of the Space Transfer Concepts and Analysis for Exploration Missions (STCAEM) study. The evolution of the NTR concept is described along with the requirements, guidelines and assumptions for the design. Operating modes and options are defined and a systems description of the vehicle is presented. Artificial gravity configuration options and space and ground support systems are discussed. Finally, an implementation plan is presented which addresses technology needs, schedules, facilities and costs.

  6. Space transfer concepts and analysis for exploration missions. Implementation plan and element description document (draft final). Volume 4: Solar electric propulsion vehicle

    NASA Astrophysics Data System (ADS)

    1991-03-01

    This document presents the solar electric propulsion (SEP) concept design developed as part of the Space Transfer Concepts and Analysis for Exploration Missions (STCAEM) study. The evolution of the SEP concept is described along with the requirements, guidelines and assumptions for the design. Operating modes and options are defined and a systems description of the vehicle is presented. Artificial gravity configuration options and space and ground support systems are discussed. Finally, an implementation plan is presented which addresses technology needs, schedules, facilities, and costs.

  7. [Environmental investigation of ground water contamination at Wright- Patterson Air Force Base, Ohio]. Volume 4, Health and Safety Plan (HSP); Phase 1, Task 4 Field Investigation report: Draft

    SciTech Connect

    Not Available

    1991-10-01

    This Health and Safety Plan (HSP) was developed for the Environmental Investigation of Ground-water Contamination Investigation at Wright-Patterson Air Force Base near Dayton, Ohio, based on the projected scope of work for the Phase 1, Task 4 Field Investigation. The HSP describes hazards that may be encountered during the investigation, assesses the hazards, and indicates what type of personal protective equipment is to be used for each task performed. The HSP also addresses the medical monitoring program, decontamination procedures, air monitoring, training, site control, accident prevention, and emergency response.

  8. Design and manufacture of wheels for a dual-mode (manned - automatic) lunar surface roving vehicle. Volume 2: Proposed test plan

    NASA Technical Reports Server (NTRS)

    1970-01-01

    A developmental test plan for the wheel and wheel drive assembly of the dual-mode (manned/automated) lunar surface roving vehicle is presented. The tests cover performance, as well as critical environmental characteristics. Insofar as practical, the environmental conditions imposed will be in the sequence expected during the hardware's life from storage through the lunar mission. Test procedures are described for static load deflection and endurance tests. Soft soil tests to determine mobility characteristics including drawbar-pull and thrust vs slip, and motion resistance for various wheel loads are also discussed. Test designs for both ambient and thermal vacuum conditions are described. Facility, transducer, and instrumentation requirements are outlined.

  9. SU-E-T-79: A Study of the Effect of Clinical Tumor Volume Displacement On the Dosage of Post Modified Radical Mastectomy Intensity-Modulated Radiation Therapy Plans for Left-Sided Breast Cancer

    SciTech Connect

    Zhang, W; Ma, C; Li, D; Wu, F

    2015-06-15

    Purpose: To explore the effect of clinical tumor volume (CTV) displacement on the dosage of intensity-modulated radiation therapy (IMRT) plans for left-sided breast cancer after modified radical mastectomy. Methods: We created 2 sets of IMRT plans based on PTV0.5 and PTV0.7 (with CTV displacement of 0.5cm and 0.7cm respectively) for each of the ten consecutive left-sided breast cancer patients after modified radical mastectomy, and compared the difference in PTV coverage and organ at risk (OAR) sparing between the two groups. And then, we compared the difference in PTV coverage in IMRT plans based on PTV0.5 between the group with properly estimated CTV displacement (presuming the actual CTV displacement was 0.5cm) and the one with underestimated CTV displacement (presuming the actual CTV displacement was 0.7cm). The difference in results between the corresponding two groups was compared using paired-sample t-test. P values less than 0.05 were considered statistically significant. Results: IMRT plans derived from PTV0.5 had more homogenous PTV coverage, and less heart, left lung, right breast, right lung, left humeral head and B-P radiation exposure, as well as less total Mu as compared with the ones stemmed from PTV0.7 (all p<0.05). IMRT plans with appropriate estimation of CTV displacement had better PTV coverage compared with the ones with underestimated CTV displacement (all p<0.01). Conclusion: The IMRT plans with smaller CTV displacement in post modified radical mastectomy radiotherapy for left-sided breast cancer has dosimetrical advantages over the ones with larger CTV displacement. Underestimation of CTV displacement can lead to significant reduction of PTV coverage. Individually quantifying and minimizing CTV displacement can significantly improve PTV coverage and OAR (including heart and left lung) sparing. This work was supported by the Medical Scientific Research Foundation of Guangdong Procvince (A2014455 to Changchun Ma)

  10. Preliminary design study of underground pumped hydro and compressed-air energy storage in hard rock. Volume 4: System planning studies

    NASA Astrophysics Data System (ADS)

    1981-04-01

    Preliminary design and planning studies of water compensated compressed air energy storage (CAES) and underground pumped hydroelectric (UPH) power plants are presented. The costs of the CAES and UPH plant designs, and the results of economic evaluations performed for the PEPCO system are presented. The PEPCO system planning analysis was performed in parallel stages with plant design development. Analyses performed early in the project indicated a requirement for 1000 MW/10,000 MWH of energy storage on a daily operating schedule, with economic installation in two segments of 500 MW in 1990 and 1997. The analysis was updated eighteen months later near the end of the project to reflect the impact of new growth projections and revised plant costs. The revised results indicated economic installations for either UPH or CAES of approximately 675 MW/6750 MWH on a daily cycle, installed in blocks of approximately 225 MW in 1990, 1993 and 1995. Significant savings in revenue requirements and oil fuel over the combustion turbine alternative were identified for both CAES and UPH.

  11. Dosimetric Comparison Between 2-Dimensional Radiation Therapy and Intensity Modulated Radiation Therapy in Treatment of Advanced T-Stage Nasopharyngeal Carcinoma: To Treat Less or More in the Planning Organ-At-Risk Volume of the Brainstem and Spinal Cord

    SciTech Connect

    Chau, Ricky Teo, Peter; Kam, Michael; Leung, S.F.; Cheung, K.Y.; Chan, Anthony

    2007-01-01

    The aim of this study is to evaluate the deficiencies in target coverage and organ protection of 2-dimensional radiation therapy (2DRT) in the treatment of advanced T-stage (T3-4) nasopharyngeal carcinoma (NPC), and assess the extent of improvement that could be achieved with intensity modulated radiation therapy (IMRT), with special reference to of the dose to the planning organ-at-risk volume (PRV) of the brainstem and spinal cord. A dosimetric study was performed on 10 patients with advanced T-stage (T3-4 and N0-2) NPC. Computer tomography (CT) images of 2.5-mm slice thickness of the head and neck were acquired with the patient immobilized in semi-extended-head position. A 2D plan based on Ho's technique, and an IMRT plan based on a 7-coplanar portals arrangement, were established for each patient. 2DRT was planned with the field borders and shielding drawn on the simulator radiograph with reference to bony landmarks, digitized, and entered into a planning computer for reconstruction of the 3D dose distribution. The 2DRT and IMRT treatment plans were evaluated and compared with respect to the dose-volume histograms (DVHs) of the targets and the organs-at-risk (OARs), tumor control probability (TCP), and normal tissue complication probabilities (NTCPs). With IMRT, the dose coverage of the target was superior to that of 2DRT. The mean minimum dose of the GTV and PTV were increased from 33.7 Gy (2DRT) to 62.6 Gy (IMRT), and 11.9 Gy (2DRT) to 47.8 Gy (IMRT), respectively. The D{sub 95} of the GTV and PTV were also increased from 57.1 Gy (2DRT) to 67 Gy (IMRT), and 45 Gy (2DRT) to 63.6 Gy (IMRT), respectively. The TCP was substantially increased to 78.5% in IMRT. Better protection of the critical normal organs was also achieved with IMRT. The mean maximum dose delivered to the brainstem and spinal cord were reduced significantly from 61.8 Gy (2DRT) to 52.8 Gy (IMRT) and 56 Gy (2DRT) to 43.6 Gy (IMRT), respectively, which were within the conventional dose limits of 54

  12. Integrated payload and mission planning, phase 3. Volume 2: Logic/Methodology for preliminary grouping of spacelab and mixed cargo payloads

    NASA Technical Reports Server (NTRS)

    Rodgers, T. E.; Johnson, J. F.

    1977-01-01

    The logic and methodology for a preliminary grouping of Spacelab and mixed-cargo payloads is proposed in a form that can be readily coded into a computer program by NASA. The logic developed for this preliminary cargo grouping analysis is summarized. Principal input data include the NASA Payload Model, payload descriptive data, Orbiter and Spacelab capabilities, and NASA guidelines and constraints. The first step in the process is a launch interval selection in which the time interval for payload grouping is identified. Logic flow steps are then taken to group payloads and define flight configurations based on criteria that includes dedication, volume, area, orbital parameters, pointing, g-level, mass, center of gravity, energy, power, and crew time.

  13. Stereotactic Body Radiotherapy for Primary Lung Cancer at a Dose of 50 Gy Total in Five Fractions to the Periphery of the Planning Target Volume Calculated Using a Superposition Algorithm

    SciTech Connect

    Takeda, Atsuya; Sanuki, Naoko; Kunieda, Etsuo Ohashi, Toshio; Oku, Yohei; Takeda, Toshiaki; Shigematsu, Naoyuki; Kubo, Atsushi

    2009-02-01

    Purpose: To retrospectively analyze the clinical outcomes of stereotactic body radiotherapy (SBRT) for patients with Stages 1A and 1B non-small-cell lung cancer. Methods and Materials: We reviewed the records of patients with non-small-cell lung cancer treated with curative intent between Dec 2001 and May 2007. All patients had histopathologically or cytologically confirmed disease, increased levels of tumor markers, and/or positive findings on fluorodeoxyglucose positron emission tomography. Staging studies identified their disease as Stage 1A or 1B. Performance status was 2 or less according to World Health Organization guidelines in all cases. The prescribed dose of 50 Gy total in five fractions, calculated by using a superposition algorithm, was defined for the periphery of the planning target volume. Results: One hundred twenty-one patients underwent SBRT during the study period, and 63 were eligible for this analysis. Thirty-eight patients had Stage 1A (T1N0M0) and 25 had Stage 1B (T2N0M0). Forty-nine patients were not appropriate candidates for surgery because of chronic pulmonary disease. Median follow-up of these 49 patients was 31 months (range, 10-72 months). The 3-year local control, disease-free, and overall survival rates in patients with Stages 1A and 1B were 93% and 96% (p = 0.86), 76% and 77% (p = 0.83), and 90% and 63% (p = 0.09), respectively. No acute toxicity was observed. Grade 2 or higher radiation pneumonitis was experienced by 3 patients, and 1 of them had fatal bacterial pneumonia. Conclusions: The SBRT at 50 Gy total in five fractions to the periphery of the planning target volume calculated by using a superposition algorithm is feasible. High local control rates were achieved for both T2 and T1 tumors.

  14. Impact of preoperative calculation of nephron volume loss on future of partial nephrectomy techniques; planning a strategic roadmap for improving functional preservation and securing oncological safety.

    PubMed

    Rha, Koon H; Abdel Raheem, Ali; Park, Sung Y; Kim, Kwang H; Kim, Hyung J; Koo, Kyo C; Choi, Young D; Jung, Byung H; Lee, Sang K; Lee, Won K; Krishnan, Jayram; Shin, Tae Y; Cho, Jin-Seon

    2017-06-20

    To assess the correlation of the resected and ischaemic volume (RAIV), which is a preoperatively calculated volume of nephron loss, with the amount of postoperative renal function (PRF) decline after minimally invasive partial nephrectomy (PN) in a multi-institutional dataset. We identified 348 patients from March 2005 to December 2013 at six institutions. Data on all cases of laparoscopic (n = 85) and robot-assisted PN (n = 263) performed were retrospectively gathered. Univariable and multivariable linear regression analyses were used to identify the associations between various time points of PRF and the RAIV, as a continuous variable. The mean (sd) RAIV was 24.2 (29.2) cm(3) . The mean preoperative estimated glomerular filtration rate (eGFR) and the eGFRs at postoperative day 1, 6 and 36 months after PN were 91.0 and 76.8, 80.2 and 87.7 mL/min/1.73 m(2) , respectively. In multivariable linear regression analysis, the amount of decline in PRF at follow-up was significantly correlated with the RAIV (β 0.261, 0.165, 0.260 at postoperative day 1, 6 and 36 months after PN, respectively). This study has the limitation of its retrospective nature. Preoperatively calculated RAIV significantly correlates with the amount of decline in PRF during long-term follow-up. The RAIV could lead our research to the level of prediction of the amount of PRF decline after PN and thus would be appropriate for assessing the technical advantages of emerging techniques. © 2017 The Authors BJU International © 2017 BJU International Published by John Wiley & Sons Ltd.

  15. Site characterization plan conceptual design report for a high-level nuclear waste repository in salt, vertical emplacement mode: Volume 1

    SciTech Connect

    Not Available

    1987-12-01

    This Conceptual Design Report describes the conceptual design of a high-level nuclear waste repository in salt at a proposed site in Deaf Smith County, Texas. Waste receipt, processing, packing, and other surface facility operations are described. Operations in the shafts underground are described, including waste hoisting, transfer, and vertical emplacement. This report specifically addresses the vertical emplacement mode, the reference design for the repository. Waste retrieval capability is described. The report includes a description of the layout of the surface, shafts, and underground. Major equipment items are identified. The report includes plans for decommissioning and sealing of the facility. The report discusses how the repository will satisfy performance objectives. Chapters are included on basis for design, design analyses, and data requirements for completion of future design efforts. 105 figs., 52 tabs.

  16. Northeast Artificial Intelligence Consortium annual report. 1988 distributed planning for dynamic environments in the presence of time constraints. Volume 5. Interim report

    SciTech Connect

    Meyer, R.A.; Conry, S.; Cohen, P.R.; Lesser, V.R.

    1989-10-01

    Our primary goal has been one of developing a distributed firefighting simulator. This is necessary in order to provide an environment in which agents can cooperatively plan to contain fires. In order to accomplish this task, a number of issues related to timing, agent synchronization, management of thinking time and acting time, and agent capabilities must be resolved. The testbed simulator has not been designed simply as a distribution of the existing centralized firefighting simulator. The issues of time and agent synchronization in a multi-agent environment necessitated a complete redesign of the simulation. The new design permits multiple agents to work simultaneously and independently. It includes a facility for defining the characteristics of communications among agents, with available communication media independently specified. In addition, the new simulator will reflect much more realistic terrain representation and a significantly improved fire model than the existing centralized simulator.

  17. Remedial Action Plan and site design for stabilization of the inactive uranium mill tailings site at Rifle, Colorado. Volume 1, Text: Appendices A, B, and C: Final report

    SciTech Connect

    1990-02-01

    This document has been structured to provide a comprehensive understanding of the remedial action proposed for the Rifle sites. That remedial action consists of removing approximately 4,185,000 cubic yards (cy) of tailings and contaminated materials from their current locations, transporting, and stabilizing the tailings material at the Estes Gulch disposal site, approximately six miles north of Rifle. The tailings and contaminated materials are comprised of approximately 597,000 cy from Old Rifle, 3,232,000 cy from New Rifle, and 322,000 cy from vicinity properties and about 34,000 cy from demolition. The remedial action plan includes specific design requirements for the detailed design and construction of the remedial action. An extensive amount of data and supporting information have been generated for this remedial action and cannot all be incorporated into this document. Pertinent information and data are included with reference given to the supporting documents.

  18. Sound Waste Management Plan environmental operations, and used oil management system: Restoration project 97115. Exxon Valdez oil spill restoration project final report: Volumes 1 and 2

    SciTech Connect

    1998-06-01

    This project constitutes Phase 2 of the Sound Waste Management Plan and created waste oil collection and disposal facilities, bilge water collection and disposal facilities, recycling storage, and household hazardous waste collection and storage, and household hazardous waste collection and storage facilities in Prince William Sound. A wide range of waste streams are generated within communities in the Sound including used oil generated from vehicles and vessels, and hazardous wastes generated by households. This project included the design and construction of Environmental Operations Stations buildings in Valdez, Cordova, Whittier, Chenega Bay and Tatitlek to improve the overall management of oily wastes. They will house new equipment to facilitate oily waste collection, treatment and disposal. This project also included completion of used oil management manuals.

  19. UNOCAL Parachute Creek Shale Oil Program. Environmental Monitoring Plan - supplemental environmental. Volume 1. Trip 2 report. Rept. for 1988-90

    SciTech Connect

    Not Available

    1991-10-01

    The Energy Security Act of 1980 established a program to provide financial assistance to private industry in the construction and operation of commercial-scale synthetic fuels plants. The Parachute Creek Shale Oil Program is one of four projects awarded financial assistance. The Program agreed to comply with existing environmental monitoring regulations and to develop an Environmental Monitoring Plan (EMP) incorporating supplemental monitoring in the areas of water, air, solid waste, and worker health and safety during the period 1985-1992. These activities are described in a series of quarterly and annual reports. The report contains results of three years of supplemental environmental sampling (Trial Trip, 1988; Trip 1, 1989; and Trip 2, 1990); Trip 2 sampling and analytical methods; quality assurance and quality control procedures; sampling and analytical methods; and corrected data from 1988 and 1989 gas and particulate concentrations.

  20. Unocal Parachute Creek Shale Oil Program. Environmental monitoring plan supplemental environmental data report. Volume 1. Trial Trip 1 sampling results. Quarterly report, September 1989-January 1990

    SciTech Connect

    Not Available

    1990-07-16

    The Energy Security Act of 1980 established a program to provide financial assistance to private industry in the construction and operation of commercial-scale synthetic fuels plants. The Parachute Creek Shale Oil Program is one of four projects awarded financial assistance. The support agreement included development of an Environmental Monitoring Plan, incorporating existing compliance monitoring and supplemental monitoring on water, air, solid waste, worker health and safety, and socioeconomic impacts during the period 1986-1993. Phase I of the project is to produce 10,000 barrels per day of syncrude from oil shale, using the Unishale B process. The report contains results for supplemental monitoring at sixteen sites; five particulates, 15 gas, 1 liquid and three solid samples are included. Concentrations are compared to environmental levels of significance.