Do people's goals for mass participation sporting events matter? A self-determination theory perspective.

PubMed

Coleman, S J; Sebire, S J

2017-12-01

Non-elite mass participation sports events (MPSEs) may hold potential as a physical activity promotion tool. Research into why people participate in these events and what goals they are pursuing is lacking. Grounded in self-determination theory, this study examined the associations between MPSE participants' goals, event experiences and physical activity. A prospective cohort study was conducted; pre-event, participants reported their goals for the event. Four weeks post-event, participants reported their motivation for exercise, perceptions of their event achievement and moderate-to-vigorous intensity physical activity (MVPA). Bivariate correlations and path analysis were performed on data from 114 adults. Intrinsic goals (e.g. health, skill and social affiliation) for the event were positively associated with perceptions of event achievement, whereas extrinsic goals (e.g. appearance or social recognition) were not. Event achievement was positively associated with post-event autonomous motivation, which in turn was positively associated with MVPA. Pursuing intrinsic but not extrinsic goals for MPSEs is associated with greater perceptions of event achievement, which in turn is associated with post-event autonomous motivation and MVPA. © The Author 2016. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

40 CFR 90.413 - Exhaust sample procedure-gaseous components.

Code of Federal Regulations, 2011 CFR

2011-07-01

... the values recorded. The number of events that may occur between the pre- and post-checks is not.... (9) Neither the zero drift nor the span drift between the pre-analysis and post-analysis checks on... Gaseous Exhaust Test Procedures § 90.413 Exhaust sample procedure—gaseous components. (a) Automatic data...

40 CFR 90.413 - Exhaust sample procedure-gaseous components.

Code of Federal Regulations, 2013 CFR

2013-07-01

... the values recorded. The number of events that may occur between the pre- and post-checks is not.... (9) Neither the zero drift nor the span drift between the pre-analysis and post-analysis checks on... Gaseous Exhaust Test Procedures § 90.413 Exhaust sample procedure—gaseous components. (a) Automatic data...

40 CFR 90.413 - Exhaust sample procedure-gaseous components.

Code of Federal Regulations, 2014 CFR

2014-07-01

... the values recorded. The number of events that may occur between the pre- and post-checks is not.... (9) Neither the zero drift nor the span drift between the pre-analysis and post-analysis checks on... Gaseous Exhaust Test Procedures § 90.413 Exhaust sample procedure—gaseous components. (a) Automatic data...

40 CFR 90.413 - Exhaust sample procedure-gaseous components.

Code of Federal Regulations, 2012 CFR

2012-07-01

... the values recorded. The number of events that may occur between the pre- and post-checks is not.... (9) Neither the zero drift nor the span drift between the pre-analysis and post-analysis checks on... Gaseous Exhaust Test Procedures § 90.413 Exhaust sample procedure—gaseous components. (a) Automatic data...

40 CFR 90.413 - Exhaust sample procedure-gaseous components.

Code of Federal Regulations, 2010 CFR

2010-07-01

... the values recorded. The number of events that may occur between the pre- and post-checks is not.... (9) Neither the zero drift nor the span drift between the pre-analysis and post-analysis checks on... Gaseous Exhaust Test Procedures § 90.413 Exhaust sample procedure—gaseous components. (a) Automatic data...

Post-Flare Giant Arches - Unanswered Questions

NASA Astrophysics Data System (ADS)

West, M. J.; Seaton, D. B.; Dennis, B. R.; Palmerio, E.; Savage, S. L.

2017-12-01

Recent observations from the SWAP EUV imager on-board PROBA2 and SXI X-ray observations from the GOES satellite have shown that post-flare giant arches and regular post-flare loops are one and the same thing. However, it is still not clear how certain loop systems are able to sustain prolonged growth to heights greater than half a solar-radii. In this presentation we further explore the energy deposition rate above post-flare loop systems through high-energy RHESSI observations. We also explore the difference between the growth of different loop systems through an epoch analysis. The epoch analysis is initially performed over the period when the STEREO satellites were in quadrature with PROBA2 allowing us to assess the difference between their on-disk and on-limb signatures. Giant arches are generally characterised by their height of growth when observed close to the solar limb, but due to the optically thin nature of the EUV solar atmosphere, projection effects and the scarcity of events occurring within 5 degrees of the limb it is not understood how common these events are. Using the analysis during the quadrature period we gain a better understanding of how rare these events are, and by determining characteristic on disk signatures we can combine our data set with magnetogram observations to better understand their magnetic evolution.

An evaluation of computer-aided disproportionality analysis for post-marketing signal detection.

PubMed

Lehman, H P; Chen, J; Gould, A L; Kassekert, R; Beninger, P R; Carney, R; Goldberg, M; Goss, M A; Kidos, K; Sharrar, R G; Shields, K; Sweet, A; Wiholm, B E; Honig, P K

2007-08-01

To understand the value of computer-aided disproportionality analysis (DA) in relation to current pharmacovigilance signal detection methods, four products were retrospectively evaluated by applying an empirical Bayes method to Merck's post-marketing safety database. Findings were compared with the prior detection of labeled post-marketing adverse events. Disproportionality ratios (empirical Bayes geometric mean lower 95% bounds for the posterior distribution (EBGM05)) were generated for product-event pairs. Overall (1993-2004 data, EBGM05> or =2, individual terms) results of signal detection using DA compared to standard methods were sensitivity, 31.1%; specificity, 95.3%; and positive predictive value, 19.9%. Using groupings of synonymous labeled terms, sensitivity improved (40.9%). More of the adverse events detected by both methods were detected earlier using DA and grouped (versus individual) terms. With 1939-2004 data, diagnostic properties were similar to those from 1993 to 2004. DA methods using Merck's safety database demonstrate sufficient sensitivity and specificity to be considered for use as an adjunct to conventional signal detection methods.

Safety Profile of Eslicarbazepine Acetate as Add-On Therapy in Adults with Refractory Focal-Onset Seizures: From Clinical Studies to 6 Years of Post-Marketing Experience.

PubMed

Gama, Helena; Vieira, Mariana; Costa, Raquel; Graça, Joana; Magalhães, Luís M; Soares-da-Silva, Patrício

2017-12-01

Eslicarbazepine acetate was first approved in the European Union in 2009 as adjunctive therapy in adults with partial-onset seizures with or without secondary generalization. The objective of this study was to review the safety profile of eslicarbazepine acetate analyzing the data from several clinical studies to 6 years of post-marketing surveillance. We used a post-hoc pooled safety analysis of four phase III, double-blind, randomized, placebo-controlled studies (BIA-2093-301, -302, -303, -304) of eslicarbazepine acetate as add-on therapy in adults. Safety data of eslicarbazepine acetate in special populations of patients aged ≥65 years with partial-onset seizures (BIA-2093-401) and subjects with moderate hepatic impairment (BIA-2093-111) and renal impairment (BIA-2093-112) are also considered. The incidences of treatment-emergent adverse events, treatment-emergent adverse events leading to discontinuation, and serious adverse events were analyzed. The global safety database of eslicarbazepine acetate was analyzed for all cases from post-marketing surveillance from 1 October, 2009 to 21 October, 2015. From a pooled analysis of four phase III studies, it was concluded that the incidence of treatment-emergent adverse events, treatment-emergent adverse events leading to discontinuation, and adverse drug reactions were dose dependent. Dizziness, somnolence, headache, and nausea were the most common treatment-emergent adverse events (≥10% of patients) and the majority were of mild-to-moderate intensity. No dose-dependent trend was observed for serious adverse events and individual serious adverse events were reported in less than 1% of patients. Hyponatremia was classified as a possibly related treatment-emergent adverse event in phase III studies (1.2%); however, after 6 years of post-marketing surveillance it represents the most frequently (10.2%) reported adverse drug reaction, with more than half of these cases occurring with eslicarbazepine acetate at daily doses of 1200 mg. Other adverse drug reactions reported in post-marketing surveillance are seizure (5.8%), dizziness (4.1%), rash (2.6%), and fatigue (2.1%). The safety profile of eslicarbazepine acetate in renal and hepatic impairment subjects (phase I studies) and in elderly patients (phase III study) did not raise any specific concern. After 6 years of post-marketing surveillance, eslicarbazepine acetate maintains a similar safety profile to that observed in pivotal clinical studies.

Systematic inference of functional phosphorylation events in yeast metabolism.

PubMed

Chen, Yu; Wang, Yonghong; Nielsen, Jens

2017-07-01

Protein phosphorylation is a post-translational modification that affects proteins by changing their structure and conformation in a rapid and reversible way, and it is an important mechanism for metabolic regulation in cells. Phosphoproteomics enables high-throughput identification of phosphorylation events on metabolic enzymes, but identifying functional phosphorylation events still requires more detailed biochemical characterization. Therefore, development of computational methods for investigating unknown functions of a large number of phosphorylation events identified by phosphoproteomics has received increased attention. We developed a mathematical framework that describes the relationship between phosphorylation level of a metabolic enzyme and the corresponding flux through the enzyme. Using this framework, it is possible to quantitatively estimate contribution of phosphorylation events to flux changes. We showed that phosphorylation regulation analysis, combined with a systematic workflow and correlation analysis, can be used for inference of functional phosphorylation events in steady and dynamic conditions, respectively. Using this analysis, we assigned functionality to phosphorylation events of 17 metabolic enzymes in the yeast Saccharomyces cerevisiae , among which 10 are novel. Phosphorylation regulation analysis cannot only be extended for inference of other functional post-translational modifications but also be a promising scaffold for multi-omics data integration in systems biology. Matlab codes for flux balance analysis in this study are available in Supplementary material. yhwang@ecust.edu.cn or nielsenj@chalmers.se. Supplementary data are available at Bioinformatics online. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Evaluating Social Media Networks in Medicines Safety Surveillance: Two Case Studies.

PubMed

Coloma, Preciosa M; Becker, Benedikt; Sturkenboom, Miriam C J M; van Mulligen, Erik M; Kors, Jan A

2015-10-01

There is growing interest in whether social media can capture patient-generated information relevant for medicines safety surveillance that cannot be found in traditional sources. The aim of this study was to evaluate the potential contribution of mining social media networks for medicines safety surveillance using the following associations as case studies: (1) rosiglitazone and cardiovascular events (i.e. stroke and myocardial infarction); and (2) human papilloma virus (HPV) vaccine and infertility. We collected publicly accessible, English-language posts on Facebook, Google+, and Twitter until September 2014. Data were queried for co-occurrence of keywords related to the drug/vaccine and event of interest within a post. Messages were analysed with respect to geographical distribution, context, linking to other web content, and author's assertion regarding the supposed association. A total of 2537 posts related to rosiglitazone/cardiovascular events and 2236 posts related to HPV vaccine/infertility were retrieved, with the majority of posts representing data from Twitter (98 and 85%, respectively) and originating from users in the US. Approximately 21% of rosiglitazone-related posts and 84% of HPV vaccine-related posts referenced other web pages, mostly news items, law firms' websites, or blogs. Assertion analysis predominantly showed affirmation of the association of rosiglitazone/cardiovascular events (72%; n = 1821) and of HPV vaccine/infertility (79%; n = 1758). Only ten posts described personal accounts of rosiglitazone/cardiovascular adverse event experiences, and nine posts described HPV vaccine problems related to infertility. Publicly available data from the considered social media networks were sparse and largely untrackable for the purpose of providing early clues of safety concerns regarding the prespecified case studies. Further research investigating other case studies and exploring other social media platforms are necessary to further characterise the usefulness of social media for safety surveillance.

An Urban Resilience to Extreme Weather Events Framework for Development of Post Event Learning and Transformative Adaptation in Cities

NASA Astrophysics Data System (ADS)

Solecki, W. D.; Friedman, E. S.; Breitzer, R.

2016-12-01

Increasingly frequent extreme weather events are becoming an immediate priority for urban coastal practitioners and stakeholders, adding complexity to decisions concerning risk management for short-term action and long-term needs of city climate stakeholders. The conflict between the prioritization of short versus long-term events by decision-makers creates disconnect between climate science and its applications. The Consortium for Climate Risk in the Urban Northeast (CCRUN), a NOAA RISA team, is developing a set of mechanisms to help bridge this gap. The mechanisms are designed to promote the application of climate science on extreme weather events and their aftermath. It is in the post event policy window where significant opportunities for science-policy linkages exist. In particular, CCRUN is interested in producing actionable and useful information for city managers to use in decision-making processes surrounding extreme weather events and climate change. These processes include a sector specific needs assessment survey instrument and two tools for urban coastal practitioners and stakeholders. The tools focus on post event learning and connections between resilience and transformative adaptation. Elements of the two tools are presented. Post extreme event learning supports urban coastal practitioners and decision-makers concerned about maximizing opportunities for knowledge transfer and assimilation, and policy initiation and development following an extreme weather event. For the urban U.S. Northeast, post event learning helps coastal stakeholders build the capacity to adapt to extreme weather events, and inform and develop their planning capacity through analysis of past actions and steps taken in response to Hurricane Sandy. Connecting resilience with transformative adaptation is intended to promote resilience in urban Northeast coastal settings to the long-term negative consequences of extreme weather events. This is done through a knowledge co-production engagement process that links innovative and flexible adaptation pathways that can address requirements for short-term action and long-term needs.

Economic impact and market analysis of a special event: The Great New England Air Show

Treesearch

Rodney B. Warnick; David C. Bojanic; Atul Sheel; Apurv Mather; Deepak Ninan

2010-01-01

We conducted a post-event evaluation for the Great New England Air Show to assess its general economic impact and to refine economic estimates where possible. In addition to the standard economic impact variables, we examined travel distance, purchase decision involvement, event satisfaction, and frequency of attendance. Graphic mapping of event visitors' home ZIP...

Influence of Japanese Regulatory Action on Denosumab-Related Hypocalcemia Using Japanese Adverse Drug Event Report Database.

PubMed

Takeyama, Mayu; Sai, Kimie; Imatoh, Takuya; Segawa, Katsunori; Hirasawa, Noriyasu; Saito, Yoshiro

2017-01-01

The anti-receptor activator of nuclear factor kappa-B ligand (RANKL) antibody, Denosumab (DEN), was approved in April 2012 in Japan, but a Dear Healthcare Professional Letter of Rapid Safety Communication was released in September, 2012 by the regulatory authority because of the severe hypocalcemia risks. Currently, the effectiveness of this regulatory action has not been evaluated and, therefore, this study aimed to assess its impact on DEN-induced hypocalcemia using the Japanese Adverse Drug Event Report database (JADER). The case reports from April 2012 to September 2014 were collected from the JADER, which included 151642 adverse events for the primary suspected drugs. The reporting odds ratio (ROR) of hypocalcemia as a signal of the target adverse event was analyzed for DEN and zoledronic acid (ZOL, a reference drug). Changes in RORs were compared between the pre- (Pre, April 2012 to September 2012) and post- (Post 1, October 2012 to September 2013 and Post 2, October 2013 to September 2014) periods of the regulatory action. A decrease in the hypocalcemia ROR was observed for DEN in the post-periods, especially Post 2. Multivariate logistic regression analysis showed a significant decrease in hypocalcemia signal in Post 1 (p=0.0306 vs. Pre) and Post 2 (p=0.0054 vs. Pre). ZOL caused no significant changes in ROR of hypocalcemia, and none of the drugs caused ROR changes in jaw osteonecrosis (a reference adverse event). This study suggests that the regulatory action against hypocalcemia in DEN effectively decreased hypocalcemia signal. Further studies using medical information databases are needed to confirm this result.

DOE Office of Scientific and Technical Information (OSTI.GOV)

A. Alfonsi; C. Rabiti; D. Mandelli

The Reactor Analysis and Virtual control ENviroment (RAVEN) code is a software tool that acts as the control logic driver and post-processing engine for the newly developed Thermal-Hydraulic code RELAP-7. RAVEN is now a multi-purpose Probabilistic Risk Assessment (PRA) software framework that allows dispatching different functionalities: Derive and actuate the control logic required to simulate the plant control system and operator actions (guided procedures), allowing on-line monitoring/controlling in the Phase Space Perform both Monte-Carlo sampling of random distributed events and Dynamic Event Tree based analysis Facilitate the input/output handling through a Graphical User Interface (GUI) and a post-processing data miningmore » module« less

Age, cumulative trauma and stressful life events, and post-traumatic stress symptoms among older adults in prison: do subjective impressions matter?

PubMed

Maschi, Tina; Morgen, Keith; Zgoba, Kristen; Courtney, Deborah; Ristow, Jennifer

2011-10-01

The aging prison population in the United States presents a significant public health challenge with high rates of trauma and mental health issues that the correctional system alone is ill-prepared to address. The purpose of this study was to examine the relationship of age, objective, and subjective measures of trauma and stressful life events and post-traumatic stress symptoms among older adults in prison. Data were gathered from 334 prisoners (aged 55+) housed in the New Jersey Department of Corrections, as of September 2010. An anonymous self-report, self-administered survey was mailed to the total population of 1,000 prisoners aged 55 years and older. Objective and subjective trauma was measured using the Life Stressors Checklist-Revised (LSC-R), and post-traumatic stress symptoms were measured using the Civilian Version of the Post-traumatic Stress Scale. Results of a path analysis revealed that past year subjective impressions of traumatic and stressful life events had a positive and significant relationship to current post-traumatic stress symptoms. Age was found to have a significant and inverse relationship to subjective traumatic and stressful life events. That is, younger participants reported higher levels of cumulative traumatic and stressful life events and past year subjective ratings of being bothered by these past events. These findings have significance for interdisciplinary/interprofessional practice and appropriate institutional and community care, including reentry planning of older adults in the criminal justice system.

Coupling Post-Event and Prospective Analyses for El Niño-related Risk Reduction in Peru

NASA Astrophysics Data System (ADS)

French, Adam; Keating, Adriana; Mechler, Reinhard; Szoenyi, Michael; Cisneros, Abel; Chuquisengo, Orlando; Etienne, Emilie; Ferradas, Pedro

2017-04-01

Analyses in the wake of natural disasters play an important role in identifying how ex ante risk reduction and ex post hazard response activities have both succeeded and fallen short in specific contexts, thereby contributing to recommendations for improving such measures in the future. Event analyses have particular relevance in settings where disasters are likely to reoccur, and especially where recurrence intervals are short. This paper applies the Post Event Review Capability (PERC) methodology to the context of frequently reoccurring El Niño Southern Oscillation (ENSO) events in the country of Peru, where over the last several decades ENSO impacts have generated high levels of damage and economic loss. Rather than analyzing the impacts of a single event, this study builds upon the existing PERC methodology by combining empirical event analysis with a critical examination of risk reduction and adaptation measures implemented both prior to and following several ENSO events in the late 20th and early 21st centuries. Additionally, the paper explores linking the empirical findings regarding the uptake and outcomes of particular risk reduction and adaptation strategies to a prospective, scenario-based approach for projecting risk several decades into the future.

Reduction in Total Cardiovascular Events With Ezetimibe/Simvastatin Post-Acute Coronary Syndrome: The IMPROVE-IT Trial.

PubMed

Murphy, Sabina A; Cannon, Christopher P; Blazing, Michael A; Giugliano, Robert P; White, Jennifer A; Lokhnygina, Yuliya; Reist, Craig; Im, KyungAh; Bohula, Erin A; Isaza, Daniel; Lopez-Sendon, Jose; Dellborg, Mikael; Kher, Uma; Tershakovec, Andrew M; Braunwald, Eugene

2016-02-02

Intensive low-density lipoprotein cholesterol therapy with ezetimibe/simvastatin in IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial) significantly reduced the first primary endpoint (PEP) in patients post-acute coronary syndrome (ACS) compared to placebo/simvastatin. This analysis tested the hypothesis that total events, including those beyond the first event, would also be reduced with ezetimibe/simvastatin therapy. All PEP events (cardiovascular [CV] death, myocardial infarction [MI], stroke, unstable angina [UA] leading to hospitalization, coronary revascularization ≥30 days post-randomization) during a median 6-year follow-up were analyzed in patients randomized to receive ezetimibe/simvastatin or placebo/simvastatin in IMPROVE-IT. Negative binomial regression was used for the primary analysis. Among 18,144 patients, there were 9,545 total PEP events (56% were first events and 44% subsequent events). Total PEP events were significantly reduced by 9% with ezetimibe/simvastatin vs placebo/simvastatin (incidence-rate ratio [RR]: 0.91; 95% confidence interval [CI]: 0.85 to 0.97; p = 0.007), as were the 3 pre-specified secondary composite endpoints and the exploratory composite endpoint of CV death, MI, or stroke (RR: 0.88; 95% CI: 0.81 to 0.96; p = 0.002). The reduction in total events was driven by decreases in total nonfatal MI (RR: 0.87; 95% CI: 0.79 to 0.96; p = 0.004) and total NF stroke (RR: 0.77; 95% CI: 0.65 to 0.93; p = 0.005). Lipid-lowering therapy with ezetimibe plus simvastatin improved clinical outcomes. Reductions in total PEP events, driven by reductions in MI and stroke, more than doubled the number of events prevented compared with examining only the first event. These data support continuation of intensive combination lipid-lowering therapy after an initial CV event. (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial [IMPROVE-IT]; NCT00202878). Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Examining the Relationships Among Self-Compassion, Social Anxiety, and Post-Event Processing.

PubMed

Blackie, Rebecca A; Kocovski, Nancy L

2017-01-01

Post-event processing refers to negative and repetitive thinking following anxiety provoking social situations. Those who engage in post-event processing may lack self-compassion in relation to social situations. As such, the primary aim of this research was to evaluate whether those high in self-compassion are less likely to engage in post-event processing and the specific self-compassion domains that may be most protective. In study 1 ( N = 156 undergraduate students) and study 2 ( N = 150 individuals seeking help for social anxiety and shyness), participants completed a battery of questionnaires, recalled a social situation, and then rated state post-event processing. Self-compassion negatively correlated with post-event processing, with some differences depending on situation type. Even after controlling for self-esteem, self-compassion remained significantly correlated with state post-event processing. Given these findings, self-compassion may serve as a buffer against post-event processing. Future studies should experimentally examine whether increasing self-compassion leads to reduced post-event processing.

29 CFR 4043.20 - Post-Event filing obligation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Post-Event filing obligation. 4043.20 Section 4043.20 Labor... EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.20 Post-Event filing obligation. The plan administrator and each contributing sponsor of a plan for which a...

29 CFR 4043.20 - Post-Event filing obligation.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 9 2014-07-01 2014-07-01 false Post-Event filing obligation. 4043.20 Section 4043.20 Labor... EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.20 Post-Event filing obligation. The plan administrator and each contributing sponsor of a plan for which a...

29 CFR 4043.20 - Post-Event filing obligation.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 9 2013-07-01 2013-07-01 false Post-Event filing obligation. 4043.20 Section 4043.20 Labor... EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.20 Post-Event filing obligation. The plan administrator and each contributing sponsor of a plan for which a...

29 CFR 4043.20 - Post-Event filing obligation.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 9 2012-07-01 2012-07-01 false Post-Event filing obligation. 4043.20 Section 4043.20 Labor... EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.20 Post-Event filing obligation. The plan administrator and each contributing sponsor of a plan for which a...

29 CFR 4043.20 - Post-Event filing obligation.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 9 2011-07-01 2011-07-01 false Post-Event filing obligation. 4043.20 Section 4043.20 Labor... EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.20 Post-Event filing obligation. The plan administrator and each contributing sponsor of a plan for which a...

Differential Roles of Thought Suppression and Dispositional Mindfulness in Posttraumatic Stress Symptoms and Craving

PubMed Central

Garland, Eric; Roberts-Lewis, Amelia

2012-01-01

Exposure to traumatic events often results in severe distress which may elicit self-medication behaviors. Yet, some individuals exposed to trauma do not develop post-traumatic stress symptoms and comorbid addictive impulses. In the wake of traumatic events, psychological processes like thought suppression and mindfulness may modulate post-traumatic stress and craving for substances. We examined the differential roles of mindfulness and suppression in comorbid post-traumatic stress and craving in a sample of 125 persons with extensive trauma histories and psychiatric symptoms in residential treatment for substance dependence. Results indicated that thought suppression, rather than extent of trauma history, significantly predicted post-traumatic stress symptom severity while dispositional mindfulness significantly predicted both post-traumatic stress symptoms and craving. In multiple regression models, mindfulness and thought suppression combined explained nearly half of the variance in post-traumatic stress symptoms and one-quarter of the variance in substance craving. Moreover, multivariate path analysis indicated that prior traumatic experience was associated with greater thought suppression, which in turn was correlated with increased post-traumatic stress symptoms and drug craving, whereas dispositional mindfulness was associated with decreased suppression, post-traumatic stress, and craving. The maladaptive strategy of thought suppression appears to be linked with adverse psychological consequences of traumatic life events. In contrast, dispositional mindfulness appears to be a protective factor that buffers individuals from experiencing more severe post-traumatic stress symptoms and craving. PMID:22385734

Predictors of post-event rumination related to social anxiety.

PubMed

Kocovski, Nancy L; Rector, Neil A

2007-01-01

Post-event processing is the cognitive rumination that follows social events in cognitive models of social anxiety. The aim of this study was to examine factors that may predict the extent to which individuals engage in post-event processing. Anxious rumination, social anxiety, anxiety sensitivity and post-event processing related to a recent anxiety-provoking social event were assessed in a college student sample (n = 439). Social anxiety and anxious rumination, but not anxiety sensitivity, significantly predicted the extent to which the participants engaged in post-event processing related to an anxiety-provoking social event. Factors that appear to impact on the post-event period include the nature of the social situation and the ethnicity of the participant. It appears that both general rumination over anxious symptoms, and specific rumination related to social events are relevant for cognitive models of social anxiety.

Clinical and Economic Impact of a Multisciplinary Intervention to Reduce Bleeding Risk in Patients With Acute Coronary Syndrome.

PubMed

de Lorenzo-Pinto, Ana; Herranz-Alonso, Ana; Cuéllar-Basterrechea, Begoña; Bellón-Cano, José María; Sanjurjo-Sáez, María; Bueno, Héctor

2017-10-01

To evaluate the clinical and economic impact of a multidisciplinary program to reduce bleeding events in patients with acute coronary syndrome through optimization of antithrombotic therapy. We designed a preintervention (PRE) and postintervention (POST) quasi-experimental study using a retrospective analysis of 2 cohorts. The first cohort was analyzed to detect correctable measures contributing to bleeding (PRE). Afterward, a quality improvement intervention with a bundle of recommendations was implemented. Finally, a second cohort of patients was evaluated to investigate the impact of the measures on bleeding reduction (POST). The impact on health outcomes was evaluated through comparison of the percentage of in-hospital bleeding events and 30-day readmissions between the 2 cohorts. The economic analysis took into account the costs associated with the implementation of the program and the cost-savings associated with the prevention of bleeding events and 30-day readmissions. A total of 677 patients were included (377 in PRE and 300 in POST). The total bleeding rate was reduced after the implementation of the bundled intervention by 29.2% (31.6% in POST vs 22.3% in PRE; OR, 0.62; 95%CI, 0.44-0.88) while 30-day readmission rates were 7.7% in PRE and 5% in POST (P=.20). The estimated avoided cost was €95 113.6 per year, meaning that €10.1 would be obtained in return for each euro invested during the first year and €36.3 during the following years. This multidisciplinary program has proven to be effective in reducing bleeding events and is economically attractive. Copyright © 2016 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.

The post-event processing questionnaire in a clinical sample with social phobia.

PubMed

McEvoy, Peter M; Kingsep, Patrick

2006-11-01

Post-event processing (PEP) involving rumination about perceived inadequacy in a past social situation has been proposed as an important maintaining factor in social phobia. The three aims of this study were to examine (a) the factor structure and internal reliability of a modified version of the Post-Event Processing Questionnaire [Rachman, S., Grüter-Andrew, J., & Shafran, R. (2000). Post-event processing in social anxiety. Behaviour Research and Therapy, 38, 611-617] in a clinical sample with social phobia (N=117), (b) the associations between PEP and symptoms of anxiety and depression, and (c) the relationship between perspective-taking ('field' and 'observer') and anxiety. Principal axis factor analysis yielded a highly reliable one-factor solution in our clinical sample, which generally replicated Rachman et al.'s findings with a sample of undergraduate students. PEP was most strongly and independently associated with state anxiety when depression, general anxiety and stress were controlled for. Contrary to expectations, PEP was not related to measures of social anxiety. The relationship between perspective-taking and anxiety was more complex than expected. Theoretical implications of these findings are discussed with reference to contemporary cognitive-behavioural models of social phobia.

Molecular analysis of post-harvest withering in grape by AFLP transcriptional profiling

PubMed Central

Zamboni, Anita; Minoia, Leone; Ferrarini, Alberto; Tornielli, Giovanni Battista; Zago, Elisa; Delledonne, Massimo; Pezzotti, Mario

2008-01-01

Post-harvest withering of grape berries is used in the production of dessert and fortified wines to alter must quality characteristics and increase the concentration of simple sugars. The molecular processes that occur during withering are poorly understood, so a detailed transcriptomic analysis of post-harvest grape berries was carried out by AFLP-transcriptional profiling analysis. This will help to elucidate the molecular mechanisms of berry withering and will provide an opportunity to select markers that can be used to follow the drying process and evaluate different drying techniques. AFLP-TP identified 699 withering-specific genes, 167 and 86 of which were unique to off-plant and on-plant withering, respectively. Although similar molecular events were revealed in both withering processes, it was apparent that off-plant withering induced a stronger dehydration stress response resulting in the high level expression of genes involved in stress protection mechanisms, such as dehydrin and osmolite accumulation. Genes involved in hexose metabolism and transport, cell wall composition, and secondary metabolism (particularly the phenolic and terpene compound pathways) were similarly regulated in both processes. This work provides the first comprehensive analysis of the molecular events underpinning post-harvest withering and could help to define markers for different withering processes. PMID:19010774

Molecular analysis of post-harvest withering in grape by AFLP transcriptional profiling.

PubMed

Zamboni, Anita; Minoia, Leone; Ferrarini, Alberto; Tornielli, Giovanni Battista; Zago, Elisa; Delledonne, Massimo; Pezzotti, Mario

2008-01-01

Post-harvest withering of grape berries is used in the production of dessert and fortified wines to alter must quality characteristics and increase the concentration of simple sugars. The molecular processes that occur during withering are poorly understood, so a detailed transcriptomic analysis of post-harvest grape berries was carried out by AFLP-transcriptional profiling analysis. This will help to elucidate the molecular mechanisms of berry withering and will provide an opportunity to select markers that can be used to follow the drying process and evaluate different drying techniques. AFLP-TP identified 699 withering-specific genes, 167 and 86 of which were unique to off-plant and on-plant withering, respectively. Although similar molecular events were revealed in both withering processes, it was apparent that off-plant withering induced a stronger dehydration stress response resulting in the high level expression of genes involved in stress protection mechanisms, such as dehydrin and osmolite accumulation. Genes involved in hexose metabolism and transport, cell wall composition, and secondary metabolism (particularly the phenolic and terpene compound pathways) were similarly regulated in both processes. This work provides the first comprehensive analysis of the molecular events underpinning post-harvest withering and could help to define markers for different withering processes.

Incidence of cardiovascular events and associated risk factors in kidney transplant patients: a competing risks survival analysis.

PubMed

Seoane-Pillado, María Teresa; Pita-Fernández, Salvador; Valdés-Cañedo, Francisco; Seijo-Bestilleiro, Rocio; Pértega-Díaz, Sonia; Fernández-Rivera, Constantino; Alonso-Hernández, Ángel; González-Martín, Cristina; Balboa-Barreiro, Vanesa

2017-03-07

The high prevalence of cardiovascular risk factors among the renal transplant population accounts for increased mortality. The aim of this study is to determine the incidence of cardiovascular events and factors associated with cardiovascular events in these patients. An observational ambispective follow-up study of renal transplant recipients (n = 2029) in the health district of A Coruña (Spain) during the period 1981-2011 was completed. Competing risk survival analysis methods were applied to estimate the cumulative incidence of developing cardiovascular events over time and to identify which characteristics were associated with the risk of these events. Post-transplant cardiovascular events are defined as the presence of myocardial infarction, invasive coronary artery therapy, cerebral vascular events, new-onset angina, congestive heart failure, rhythm disturbances, peripheral vascular disease and cardiovascular disease and death. The cause of death was identified through the medical history and death certificate using ICD9 (390-459, except: 427.5, 435, 446, 459.0). The mean age of patients at the time of transplantation was 47.0 ± 14.2 years; 62% were male. 16.5% had suffered some cardiovascular disease prior to transplantation and 9.7% had suffered a cardiovascular event. The mean follow-up period for the patients with cardiovascular event was 3.5 ± 4.3 years. Applying competing risk methodology, it was observed that the accumulated incidence of the event was 5.0% one year after transplantation, 8.1% after five years, and 11.9% after ten years. After applying multivariate models, the variables with an independent effect for predicting cardiovascular events are: male sex, age of recipient, previous cardiovascular disorders, pre-transplant smoking and post-transplant diabetes. This study makes it possible to determine in kidney transplant patients, taking into account competitive events, the incidence of post-transplant cardiovascular events and the risk factors of these events. Modifiable risk factors are identified, owing to which, changes in said factors would have a bearing of the incidence of events.

Computational challenges, tools and resources for analyzing co- and post-transcriptional events in high throughput

PubMed Central

Bahrami-Samani, Emad; Vo, Dat T.; de Araujo, Patricia Rosa; Vogel, Christine; Smith, Andrew D.; Penalva, Luiz O. F.; Uren, Philip J.

2014-01-01

Co- and post-transcriptional regulation of gene expression is complex and multi-faceted, spanning the complete RNA lifecycle from genesis to decay. High-throughput profiling of the constituent events and processes is achieved through a range of technologies that continue to expand and evolve. Fully leveraging the resulting data is non-trivial, and requires the use of computational methods and tools carefully crafted for specific data sources and often intended to probe particular biological processes. Drawing upon databases of information pre-compiled by other researchers can further elevate analyses. Within this review, we describe the major co- and post-transcriptional events in the RNA lifecycle that are amenable to high-throughput profiling. We place specific emphasis on the analysis of the resulting data, in particular the computational tools and resources available, as well as looking towards future challenges that remain to be addressed. PMID:25515586

Post-event debriefings during neonatal care: why are we not doing them, and how can we start?

PubMed

Sawyer, T; Loren, D; Halamek, L P

2016-06-01

Post-event debriefings are a foundational behavior of high performing teams. Despite the inherent value of post-event debriefings, the frequency with which they are used in neonatal care is extremely low. If post-event debriefings are so beneficial, why aren't they conducted more frequently? The reasons are many, but solutions are available. In this report, we provide practical advice on conducting post-event debriefing in neonatal care. In addition, we examine the perceived barriers to conducting post-event debriefings, and offer strategies to overcome them. Finally, we consider opportunities to foster a culture change within neonatal care which integrates debriefing as standard daily work. By establishing a safety culture in neonatal care that encourages and facilitates effective post-event debriefings, patient safety can be enhanced and clinical outcomes can be improved.

Long-Term Retrospective Analysis of Gene Therapy with Alipogene Tiparvovec and Its Effect on Lipoprotein Lipase Deficiency-Induced Pancreatitis.

PubMed

Gaudet, Daniel; Stroes, Erik S; Méthot, Julie; Brisson, Diane; Tremblay, Karine; Bernelot Moens, Sophie J; Iotti, Giorgio; Rastelletti, Irene; Ardigo, Diego; Corzo, Deyanira; Meyer, Christian; Andersen, Marc; Ruszniewski, Philippe; Deakin, Mark; Bruno, Marco J

2016-11-01

Alipogene tiparvovec (Glybera) is a gene therapy product approved in Europe under the "exceptional circumstances" pathway as a treatment for lipoprotein lipase deficiency (LPLD), a rare genetic disease resulting in chylomicronemia and a concomitantly increased risk of acute and recurrent pancreatitis, with potentially lethal outcome. This retrospective study analyzed the frequency and severity of pancreatitis in 19 patients with LPLD up to 6 years after a single treatment with alipogene tiparvovec. An independent adjudication board of three pancreas experts, blinded to patient identification and to pre- or post-gene therapy period, performed a retrospective review of data extracted from the patients' medical records and categorized LPLD-related acute abdominal pain events requiring hospital visits and/or hospitalizations based on the adapted 2012 Atlanta diagnostic criteria for pancreatitis. Both entire disease time period data and data from an equal time period before and after gene therapy were analyzed. Events with available medical record information meeting the Atlanta diagnostic criteria were categorized as definite pancreatitis; events treated as pancreatitis but with variable levels of laboratory and imaging data were categorized as probable pancreatitis or acute abdominal pain events. A reduction of approximately 50% was observed in all three categories of the adjudicated post-gene therapy events. Notably, no severe pancreatitis and only one intensive care unit admission was observed in the post-alipogene tiparvovec period. However, important inter- and intraindividual variations in the pre- and post-gene therapy incidence of events were observed. There was no relationship between the posttreatment incidence of events and the number of LPL gene copies injected, the administration of immunosuppressive regimen or the percent triglyceride decrease achieved at 12 weeks (primary end point in the prospective clinical studies). Although a causal relationship cannot be established and despite the limited number of individuals evaluated, results from this long-term analysis suggest that alipogene tiparvovec was associated with a lower frequency and severity of pancreatitis events, and a consequent overall reduction in health care resource use up to 6 years posttreatment.

Exploring the effect of alcohol on post-event processing specific to a social event.

PubMed

Battista, Susan R; Kocovski, Nancy L

2010-01-01

Inconsistent findings regarding the relationship between social anxiety and alcohol use suggest that further research is needed to explore how alcohol affects various components of social anxiety. Post-event processing, or rumination after social events, is an element of cognitive models of social anxiety that is related to increased levels of social anxiety. The goal of the current study was to explore the interrelationships among social anxiety, post-event processing, and alcohol use. A sample of 208 university students completed online questionnaires to assess their levels of trait social anxiety and trait depression as well as their alcohol consumption at a specific social event. Participants then completed questionnaires to assess levels of post-event processing specific to the social event they attended. Results revealed that the amount of alcohol individuals consumed at the event predicted increased levels of post-event processing above and beyond levels of trait social anxiety and depression. As such, drinking may lead to increased post-event processing in student samples.

A coupled hydrological-hydraulic flood inundation model calibrated using post-event measurements and integrated uncertainty analysis in a poorly gauged Mediterranean basin

NASA Astrophysics Data System (ADS)

Hdeib, Rouya; Abdallah, Chadi; Moussa, Roger; Colin, Francois

2017-04-01

Developing flood inundation maps of defined exceedance probabilities is required to provide information on the flood hazard and the associated risk. A methodology has been developed to model flood inundation in poorly gauged basins, where reliable information on the hydrological characteristics of floods are uncertain and partially captured by the traditional rain-gauge networks. Flood inundation is performed through coupling a hydrological rainfall-runoff (RR) model (HEC-HMS) with a hydraulic model (HEC-RAS). The RR model is calibrated against the January 2013 flood event in the Awali River basin, Lebanon (300 km2), whose flood peak discharge was estimated by post-event measurements. The resulting flows of the RR model are defined as boundary conditions of the hydraulic model, which is run to generate the corresponding water surface profiles and calibrated against 20 post-event surveyed cross sections after the January-2013 flood event. An uncertainty analysis is performed to assess the results of the models. Consequently, the coupled flood inundation model is simulated with design storms and flood inundation maps are generated of defined exceedance probabilities. The peak discharges estimated by the simulated RR model were in close agreement with the results from different empirical and statistical methods. This methodology can be extended to other poorly gauged basins facing common stage-gauge failure or characterized by floods with a stage exceeding the gauge measurement level, or higher than that defined by the rating curve.

An Analysis of Post-Traumatic Stress Symptoms in United States Air Force Drone Operators

DTIC Science & Technology

2014-05-17

war-time imagery (i.e., potential traumatic events). Ouma, Chappelle, and Salinas (2011) investigated self- reported stress and burnout among 296 USAF...related directly to operational factors (e.g., long work hours, disruptive shift schedules, daily balance of warfighter with domestic duties). Mental...Journal Article 3. DATES COVERED (From – To) Jan 2012 – Dec 2012 4. TITLE AND SUBTITLE An analysis of post-traumatic stress symptoms in United

What's in a story? A text analysis of burn survivors' web-posted narratives.

PubMed

Badger, Karen; Royse, David; Moore, Kelly

2011-01-01

Story-telling has been found to be beneficial following trauma, suggesting a potential intervention for burn survivors who frequently make use of? telling their story? as part of their recovery. This study is the first to examine the word content of burn survivors' Web-posted narratives to explore their perceptions of the event, supportive resources, their post-burn well-being, and re-integration using a comparison group and a text data analysis software developed by the widely recognized James Pennebaker. Suggestions for using expressive writing or story-telling as a guided psychosocial intervention with burn survivors are made.

Post-event information presented in a question form eliminates the misinformation effect.

PubMed

Lee, Yuh-shiow; Chen, Kuan-Nan

2013-02-01

This study investigated the influences of sentence surface forms on the misinformation effect. After viewing a film clip, participants received a post-event narrative describing the events in the film. Critical sentences in the post-event narrative, presented in either a statement or a question form, contained misinformation instead of questions with embedded false presuppositions; thus participants did not have to answer questions about the original event. During the final cued-recall test, participants were informed that any relevant information presented in the post-event narrative was not in the original event and that they should not report it. Consistent with previous findings, Experiment 1 demonstrated that post-event information presented as an affirmative statement produced the misinformation effect. More importantly, post-event information presented in a question form, regardless of whether it contained a misleading or studied item, increased the recall of correct information and reduced false recall. Experiment 2 replicated the main finding and ruled out an alternative explanation based on the salience of misleading items. Post-event information presented in a question form created a condition similar to that which produces the testing effect. © 2012 The British Psychological Society.

The electrical heart axis and ST events in fetal monitoring: A post-hoc analysis following a multicentre randomised controlled trial.

PubMed

Vullings, Rik; Verdurmen, Kim M J; Hulsenboom, Alexandra D J; Scheffer, Stephanie; de Lau, Hinke; Kwee, Anneke; Wijn, Pieter F F; Amer-Wåhlin, Isis; van Laar, Judith O E H; Oei, S Guid

2017-01-01

Reducing perinatal morbidity and mortality is one of the major challenges in modern health care. Analysing the ST segment of the fetal electrocardiogram was thought to be the breakthrough in fetal monitoring during labour. However, its implementation in clinical practice yields many false alarms and ST monitoring is highly dependent on cardiotocogram assessment, limiting its value for the prediction of fetal distress during labour. This study aims to evaluate the relation between physiological variations in the orientation of the fetal electrical heart axis and the occurrence of ST events. A post-hoc analysis was performed following a multicentre randomised controlled trial, including 1097 patients from two participating centres. All women were monitored with ST analysis during labour. Cases of fetal metabolic acidosis, poor signal quality, missing blood gas analysis, and congenital heart disease were excluded. The orientation of the fetal electrical heart axis affects the height of the initial T/QRS baseline, and therefore the incidence of ST events. We grouped tracings with the same initial baseline T/QRS value. We depicted the number of ST events as a function of the initial baseline T/QRS value with a linear regression model. A significant increment of ST events was observed with increasing height of the initial T/QRS baseline, irrespective of the fetal condition; correlation coefficient 0.63, p<0.001. The most frequent T/QRS baseline is 0.12. The orientation of the fetal electrical heart axis and accordingly the height of the initial T/QRS baseline should be taken into account in fetal monitoring with ST analysis.

Potentially traumatic events have negative and positive effects on loneliness, depending on PTSD-symptom levels: evidence from a population-based prospective comparative study.

PubMed

van der Velden, Peter G; Pijnappel, Bas; van der Meulen, Erik

2018-02-01

Examine to what extent adults affected by recent potentially traumatic events (PTE) with different PTSD-symptom levels are more at risk for post-event loneliness than non-affected adults are in the same study period. We extracted data from the Dutch longitudinal LISS panel to measure pre-event loneliness (2011) and post-event loneliness (2013 and 2014), pre-event mental health problems (2011), PTE and PTSD symptoms (2012). This panel is based on a traditional random sample drawn from the population register by Statistics Netherlands. Results of the multinomial logistic regression analyses showed that affected adults with high levels of PTSD symptoms were more at risk for high levels of post-event loneliness than affected adults with very low PTSD-symptom levels and non-affected adults, while controlling for pre-event loneliness, pre-event mental health problems and demographics. However, affected adults with very low levels of PTSD symptoms compared to non-affected adults were less at risk for medium and high levels of post-event loneliness while controlling for the same variables. Yet, pre-event loneliness appeared to be the strongest independent predictor of loneliness at later stages: more than 80% with high pre-event levels had high post-event levels at both follow-ups. Remarkably, potentially traumatic events have depending on PTSD-symptom levels both negative and positive effects on post-event loneliness in favor of affected adults with very low PTSD symptoms levels. However, post-event levels at later stages are predominantly determined by pre-event loneliness levels.

Distress after a single violent crime: how shame-proneness and event-related shame work together as risk factors for post-victimization symptoms.

PubMed

Semb, Olof; Strömsten, Lotta M J; Sundbom, Elisabet; Fransson, Per; Henningsson, Mikael

2011-08-01

To increase understanding of post-victimization symptom development, the present study investigated the role of shame- and guilt-proneness and event-related shame and guilt as potential risk factors. 35 individuals (M age = 31.7 yr.; 48.5% women), recently victimized by a single event of severe violent crime, were assessed regarding shame- and guilt-proneness, event-related shame and guilt, and post-victimization symptoms. The mediating role of event-related shame was investigated with structural equation modeling (SEM), using bootstrapping. The guilt measures were unrelated to each other and to post-victimization symptoms. The shame measures were highly intercorrelated and were both positively correlated to more severe post-victimization symptom levels. Event-related shame as mediator between shame-proneness and post-victimization symptoms was demonstrated by prevalent significant indirect effects. Both shame measures are potent risk factors for distress after victimization, whereby part of the effect of shame-proneness on post-victimization symptoms is explained by event-related shame.

Flood damage: a model for consistent, complete and multipurpose scenarios

NASA Astrophysics Data System (ADS)

Menoni, Scira; Molinari, Daniela; Ballio, Francesco; Minucci, Guido; Mejri, Ouejdane; Atun, Funda; Berni, Nicola; Pandolfo, Claudia

2016-12-01

Effective flood risk mitigation requires the impacts of flood events to be much better and more reliably known than is currently the case. Available post-flood damage assessments usually supply only a partial vision of the consequences of the floods as they typically respond to the specific needs of a particular stakeholder. Consequently, they generally focus (i) on particular items at risk, (ii) on a certain time window after the occurrence of the flood, (iii) on a specific scale of analysis or (iv) on the analysis of damage only, without an investigation of damage mechanisms and root causes. This paper responds to the necessity of a more integrated interpretation of flood events as the base to address the variety of needs arising after a disaster. In particular, a model is supplied to develop multipurpose complete event scenarios. The model organizes available information after the event according to five logical axes. This way post-flood damage assessments can be developed that (i) are multisectoral, (ii) consider physical as well as functional and systemic damage, (iii) address the spatial scales that are relevant for the event at stake depending on the type of damage that has to be analyzed, i.e., direct, functional and systemic, (iv) consider the temporal evolution of damage and finally (v) allow damage mechanisms and root causes to be understood. All the above features are key for the multi-usability of resulting flood scenarios. The model allows, on the one hand, the rationalization of efforts currently implemented in ex post damage assessments, also with the objective of better programming financial resources that will be needed for these types of events in the future. On the other hand, integrated interpretations of flood events are fundamental to adapting and optimizing flood mitigation strategies on the basis of thorough forensic investigation of each event, as corroborated by the implementation of the model in a case study.

Analysis of the Seismic Events Apparently Associated with the 3 September 2017 DPRK Declared Nuclear Explosion

NASA Astrophysics Data System (ADS)

Walter, W. R.; Dodge, D. A.; Ichinose, G.; Myers, S. C.; Ford, S. R.; Pitarka, A.; Pyle, M. L.; Pasyanos, M.; Matzel, E.; Rodgers, A. J.; Mellors, R. J.; Hauk, T. F.; Kroll, K.

2017-12-01

On September 3, 2017, an mb 6.3 seismic event was reported by the USGS in the vicinity of the DPRK nuclear test site at Punggye-ri. Shortly afterwards DPRK declared it had conducted a nuclear explosion. The seismic signals indicate this event is roughly an order of magnitude larger than the largest of the previous five DPRK declared nuclear tests. In addition to its size, this explosion was different from previous DPRK tests in being associated with a number of additional seismic events. Approximately eight and a half minutes after the explosion a seismic event reported as ML 4.0 by the USGS occurred. Regional waveform modeling indicated this event had a collapse mechanism (e.g. Ichinose et al., 2017, written communication). On September 23 and again on October 12, 2017, seismic events were reported near the DPRK test site by the USGS and the CTBTO (on 9/23/17 two events: USGS ML 3.6 and USGS ML 2.6; and on 10/12/17 one event: USGS mb(Lg) 2.9). Aftershocks following underground nuclear testing are expected, though at much lower magnitudes and rates than for comparably sized earthquakes. This difference in aftershock production has been proposed by Ford and Walter (2010), and others as a potential source-type discriminant. Seismic signals from the collapse of cavities formed by underground nuclear testing have also been previously observed. For example, the mb 5.7 nuclear test ATRISCO in Nevada in 1982 was followed twenty minutes later by a collapse with an mb of 4.0. Here we examine the seismic characteristics of nuclear tests, post-test collapses and post-test aftershocks from both the former Nevada test site and the DPRK test site to better understand the differences between these different source-type signals. In particular we look at discriminants such as P/S ratios, to see if there are unique characteristics to post-test collapses and aftershocks. Finally, we apply correlation methods to continuous data at regional stations to look for additional seismic signals that might have an apparent association with the DPRK nuclear testing, post-testing collapses and post-test induced seismicity.

Post-partum blues among Korean mothers: a structural equation modelling approach.

PubMed

Chung, Sung Suk; Yoo, Il Young; Joung, Kyoung Hwa

2013-08-01

The objective of this study was to propose the post-partum blues (PPB) model and to estimate the effects of self-esteem, social support, antenatal depression, and stressful events during pregnancy on PPB. Data were collected from 249 women post-partum during their stay in the maternity units of three hospitals in Korea using a self-administered questionnaire. A structural equation modelling approach using the Analysis of Moments Structure program was used to identify the direct and indirect effects of the variables on PPB. The full model had a good fit and accounted for 70.3% of the variance of PPB. Antenatal depression and stressful events during pregnancy had strong direct effects on PPB. Household income showed indirect effects on PPB via self-esteem and antenatal depression. Social support indirectly affected PPB via self-esteem, antenatal depression, and stressful events during pregnancy. © 2012 The Authors; International Journal of Mental Health Nursing © 2012 Australian College of Mental Health Nurses Inc.

Superstition and post-tonsillectomy hemorrhage.

PubMed

Kumar, Veena V; Kumar, Naveen V; Isaacson, Glenn

2004-11-01

The objective was to determine whether post-tonsillectomy hemorrhages occur more frequently in redheaded children, in patterns of threes, on Friday-the-13th days, or with the full moon. Case-control analysis. The authors performed multiple statistical analyses of all children undergoing tonsillectomy at Temple University Children's Medical Center (Philadelphia, PA) during a 29-month period. Children readmitted to the hospital with or without surgical control of bleeding were compared with children who did not bleed. Relation of post-tonsillectomy hemorrhages to the phase of the moon was evaluated using a standard normal deviate. The frequency of surgery performed on Friday-the-13th days was compared with a differently dated Friday chosen at random. Clusters of three hemorrhages in a 7-day period were recorded. Families of children were contacted and asked whether their child had red hair. A chi analysis compared redheaded and non-redheaded tonsillectomy patients. Twenty-eight of 589 tonsillectomy cases performed required readmission for bleeding events. Twenty tonsillectomies occurred on a full-moon day, resulting in one bleeding event. One cluster of three post-tonsillectomy hemorrhages occurred in a 7-day period. Four of the children who bled had red hair. Two tonsillectomies occurred on Friday the 13th, with no associated hemorrhage. Statistical analysis revealed a random pattern to post-tonsillectomy hemorrhage. Post-tonsillectomy hemorrhages do not occur in clusters of three and are not more frequent with the full moon or on Friday the 13th. The bleeding rate among children with red hair is similar to that of non-redheaded children.

Thermal Analysis of Post-eruption Loops from 80,000 to 1.6 million K

NASA Technical Reports Server (NTRS)

Kucera, T.; Landi, E.

2006-01-01

We analyze the thermal properties of a set of post eruptive loops which appeared after a prominence eruption on April 30, 2004. The event was observed by TRACE and SOHO/SUMER. The SUMER data was taken from a single slit location with a 90 second cadence and included a number of lines spanning the temperature range 80,000 to 1.6 million K. We perform a differential emission measure analysis of the loops in order to study their thermal evolution.

Understanding Impact and Implications of Data Standards on Post Disaster Risk Analysis

NASA Astrophysics Data System (ADS)

Stevenson, Robert

2010-05-01

Although the physical and humanitarian effects of a natural catastrophe are often bound to the locality of the event the financial impacts can have global effects. This is particularly prominent in the re/insurance community, where through a number of market mechanisms and re/insurance structures financial loss is mitigated amongst many companies across the globe. The level of risk a company wishes to retain, given an event, represents the level of risk decision makers deem acceptable. Catastrophe risk modelling tools aid the estimation of risk retention and transfer mechanisms, and increasingly the level of capital required to withstand a catastrophic event. These tools rely on appropriate representations hazard, exposure, vulnerability and insurance conditions that reflect the reality of risk. In addition, accurate estimation of loss potential in the aftermath of a catastrophic event equally relies on the data available to assess the scale of damages experienced and to provide views on the likely scale of loss. A coherent and focussed data and modelling strategy is required to ensure that the risk assessment made is as accurate as possible. A fundamental factor in determining the accuracy of catastrophe output, is the quality of data entered. It is of vital importance, therefore, to have an understanding of both the data used as well as the standard of this data, which will so powerfully impact upon the decision making process. This is perhaps best illustrated through the study of historical events, such as Hurricane Katrina and Ike. The extent of data variance in post disaster analysis clearly demonstrates issues of data discrepancies, vintage, resolution and uncertainty propagation, and reflects on the standard of the original data utilized for modelling purposes and decision making. Using experience gained from recent events, this paper will explore current data variabilities, and the impacts on effective loss estimation, both in relation to reinsurance structuring, but also in terms of effective post-event analysis. It will provide views on how data is currently applied in this context, and will make suggestions as to the most important areas for future data improvements.

A population-based study of disability and institutionalisation after TIA and stroke: 10-year results of the Oxford Vascular Study

PubMed Central

Luengo-Fernandez, Ramon; Paul, Nicola L.M.; Gray, Alastair M.; Pendlebury, Sarah T.; Bull, Linda M.; Welch, Sarah J.V.; Cuthbertson, Fiona C.; Rothwell, Peter M.

2016-01-01

Background and Purpose Long-term outcome information after TIA and stroke is required to help plan and allocate care services. We evaluated the impact of TIA and stroke on disability and institutionalisation over 5 years using data from a population-based study. Methods Patients from a UK population-based cohort study (Oxford Vascular Study) were recruited from 2002 to 2007, and followed-up to 2012. Patients were followed-up at 1, 6, 12, 24 and 60 months post-event and assessed using the modified Rankin Scale (mRS). A multivariate regression analysis was performed to assess the predictors of disability post-event. Results 748 index stroke and 440 TIA cases were studied. For TIA patients, disability levels increased from 14% (63/440) pre-morbidly to 23% (60/256) at 5 years (p=0.002), with occurrence of subsequent stroke being a major predictor of disability. For stroke survivors, the proportion disabled (mRS>2) increased from 21% (154/748) pre-morbidly to 43% (273/634) at 1-month (p<0.001), with 39% (132/339) of survivors disabled 5 years post-stroke. 5 years post-event, 70% (483/690) of stroke patients and 48% (179/375) of TIA patients were either dead or disabled. The 5-year risk of care home institutionalisation was 11% after TIA and 19% after stroke. The average 5-year cost per institutionalised TIA patient was $99,831 (S.D. 67,020) and $125,359 (S.D. 91,121) for stroke patients. Conclusions Our results show that 70% of stroke patients are either dead or disabled 5 years after the event. There therefore remains considerable scope for improvements in acute treatment and secondary prevention to reduce post-event disability and institutionalisation. PMID:23920019

49 CFR 229.211 - Processing of petitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Docket Management System and posted on its Web site at http://www.regulations.gov. (3) In the event FRA..., FRA will consider proper documentation of competent engineering analysis, or practical demonstrations...

49 CFR 229.211 - Processing of petitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Docket Management System and posted on its Web site at http://www.regulations.gov. (3) In the event FRA..., FRA will consider proper documentation of competent engineering analysis, or practical demonstrations...

Media experiences and associations with mental health among the bereaved of the MH17-disaster: A latent profile analysis.

PubMed

van der Velden, Peter G; van der Meulen, Erik; Lenferink, Lonneke I M; Yzermans, Joris C

2018-06-01

Research has shown that the amount of media exposure is associated with post-event mental health problems. Whether bereaved individuals have negative experiences with media reports and whether they are associated with post-event mental health is unclear. This study evaluated these experiences and associations following the MH17-disaster. How media reports were experienced (nine topics, modified MAS), depression symptoms (QIDS-SR), functional problems (WSAS) and event-related coping-self-efficacy (CSE) were assessed about one year post-disaster (May-August 2015) among Dutch bereaved (N = 152). A substantial minority reported negative experiences such as reports made me angry (30%) and made me sad (48%). Latent profile analysis with symptoms, problems and coping self-efficacy as indicators, identified four classes of post-disaster mental health: a Well-functioning (class 1) , 35.1%; a Mild-problems (class 2) , 30.4%; a Sub-clinical (class 3) , 27.0%; and a Clinical (class 4) , 7.4%. Differences in symptoms, problems and coping self-efficacy levels between classes were large according to Cohen's ds. Multivariate logistic regression (MLR) showed that the Clinical (class 4) compared to the Well-functioning (class 1) , more often that felt that reports strongly "embarrassed me," "made me feel sad," "filled me with fear" and "served as a magnifying glass." Future research should assess opportunities and effects of limiting media consumption. © 2018 Tilburg University. Scandinavian Journal of Psychology published by Scandinavian Psychological Associations and John Wiley & Sons Ltd.

Longitudinal modelling of theory-based depressive vulnerabilities, depression trajectories and poor outcomes post-ACS.

PubMed

Keegan, Conor; Conroy, Ronán; Doyle, Frank

2016-02-01

Depression is associated with increased mortality in patients with acute coronary syndrome (ACS). However, little is known about the theoretical causes of depression trajectories post-ACS, and whether these trajectories predict subsequent morbidity/mortality. We tested a longitudinal model of depressive vulnerabilities, trajectories and mortality. A prospective observational study of 374 ACS patients was conducted. Participants completed questionnaires on theoretical vulnerabilities (interpersonal life events, reinforcing events, cognitive distortions, and Type D personality) during hospitalisation and depression at baseline and 3, 6 and 12 months post-hospitalisation. Latent class analysis determined trajectories of depression. Path analysis was used to test relationships among vulnerabilities, depression trajectories and outcomes (combination of 1-year morbidity and 7-year mortality). Vulnerabilities independently predicted persistent and subthreshold depression trajectory categories, with effect sizes significantly highest for persistent depression. Both subthreshold and persistent depression trajectories were significant predictors of morbidity/mortality (e.g. persistent depression OR=2.4, 95% CI=1.8-3.1, relative to never depressed). Causality cannot be inferred from these associations. We had no measures of history of depression or treatments, which may affect associations. Theoretical vulnerabilities predicted depression trajectories, which in turn predicted increased morbidity/mortality, demonstrating for the first time a potential longitudinal chain of events post-ACS. This longitudinal model has important practical implications as clinicians can use vulnerability measures to identify those at most risk of poor outcomes. Copyright © 2015. Published by Elsevier B.V.

CARA Risk Assessment Thresholds

NASA Technical Reports Server (NTRS)

Hejduk, M. D.

2016-01-01

Warning remediation threshold (Red threshold): Pc level at which warnings are issued, and active remediation considered and usually executed. Analysis threshold (Green to Yellow threshold): Pc level at which analysis of event is indicated, including seeking additional information if warranted. Post-remediation threshold: Pc level to which remediation maneuvers are sized in order to achieve event remediation and obviate any need for immediate follow-up maneuvers. Maneuver screening threshold: Pc compliance level for routine maneuver screenings (more demanding than regular Red threshold due to additional maneuver uncertainty).

Naturalistic Cycling Study: Identifying Risk Factors for On-Road Commuter Cyclists

PubMed Central

Johnson, Marilyn; Charlton, Judith; Oxley, Jennifer; Newstead, Stuart

2010-01-01

The study aim was to identify risk factors for collisions/near-collisions involving on-road commuter cyclists and drivers. A naturalistic cycling study was conducted in Melbourne, Australia, with cyclists wearing helmet-mounted video cameras. Video recordings captured cyclists’ perspective of the road and traffic behaviours including head checks, reactions and manoeuvres. The 100-car naturalistic driving study analysis technique was adapted for data analysis and events were classified by severity: collision, near-collision and incident. Participants were adult cyclists and each filmed 12 hours of commuter cycling trips over a 4-week period. In total, 127 hours and 38 minutes were analysed for 13 participants, 54 events were identified: 2 collisions, 6 near-collisions and 46 incidents. Prior to events, 88.9% of cyclists travelled in a safe/legal manner. Sideswipe was the most frequent event type (40.7%). Most events occurred at an intersection/intersection-related location (70.3%). The vehicle driver was judged at fault in the majority of events (87.0%) and no post-event driver reaction was observed (83.3%). Cross tabulations revealed significant associations between event severity and: cyclist reaction, cyclist post-event manoeuvre, pre-event driver behaviour, other vehicle involved, driver reaction, visual obstruction, cyclist head check (left), event type and vehicle location (p<0.05). Frequent head checks suggest cyclists had high situational awareness and their reactive behaviour to driver actions led to successful avoidance of collisions/near-collisions. Strategies to improve driver awareness of on-road cyclists and to indicate early before turning/changing lanes when sharing the roadway with cyclists are discussed. Findings will contribute to the development of effective countermeasures to reduce cyclist trauma. PMID:21050610

Naturalistic cycling study: identifying risk factors for on-road commuter cyclists.

PubMed

Johnson, Marilyn; Charlton, Judith; Oxley, Jennifer; Newstead, Stuart

2010-01-01

The study aim was to identify risk factors for collisions/near-collisions involving on-road commuter cyclists and drivers. A naturalistic cycling study was conducted in Melbourne, Australia, with cyclists wearing helmet-mounted video cameras. Video recordings captured cyclists' perspective of the road and traffic behaviours including head checks, reactions and manoeuvres. The 100-car naturalistic driving study analysis technique was adapted for data analysis and events were classified by severity: collision, near-collision and incident. Participants were adult cyclists and each filmed 12 hours of commuter cycling trips over a 4-week period. In total, 127 hours and 38 minutes were analysed for 13 participants, 54 events were identified: 2 collisions, 6 near-collisions and 46 incidents. Prior to events, 88.9% of cyclists travelled in a safe/legal manner. Sideswipe was the most frequent event type (40.7%). Most events occurred at an intersection/intersection-related location (70.3%). The vehicle driver was judged at fault in the majority of events (87.0%) and no post-event driver reaction was observed (83.3%). Cross tabulations revealed significant associations between event severity and: cyclist reaction, cyclist post-event manoeuvre, pre-event driver behaviour, other vehicle involved, driver reaction, visual obstruction, cyclist head check (left), event type and vehicle location (p<0.05). Frequent head checks suggest cyclists had high situational awareness and their reactive behaviour to driver actions led to successful avoidance of collisions/near-collisions. Strategies to improve driver awareness of on-road cyclists and to indicate early before turning/changing lanes when sharing the roadway with cyclists are discussed. Findings will contribute to the development of effective countermeasures to reduce cyclist trauma.

The effect of tranexamic acid on the risk of death and hysterectomy in women with post-partum haemorrhage: statistical analysis plan for the WOMAN trial.

PubMed

Shakur, Haleema; Roberts, Ian; Edwards, Philip; Elbourne, Diana; Alfirevic, Zarko; Ronsmans, Carine

2016-05-17

Severe haemorrhage is a leading cause of maternal death worldwide. Most haemorrhage deaths occur soon after childbirth. Severe post-partum bleeding is sometimes managed by the surgical removal of the uterus (hysterectomy). Death and hysterectomy are important health consequences of post-partum haemorrhage, and clinical trials of interventions aimed at preventing these outcomes are needed. The World Maternal Antifibrinolytic trial aims to determine the effect of tranexamic acid on death, hysterectomy and other health outcomes in women with post-partum haemorrhage. It is an international, multicentre, randomised trial. Approximately 20,000 women with post-partum haemorrhage will be randomly allocated to receive an intravenous injection of either tranexamic acid or matching placebo in addition to usual care. The primary outcome measure is a composite of death in hospital or hysterectomy within 42 days of delivery. The cause of death will be described. Secondary outcomes include death, death due to bleeding, hysterectomy, thromboembolic events, blood transfusion, surgical and radiological interventions, complications, adverse events and quality of life. The health status and occurrence of thromboembolic events in breastfed babies will also be reported. We will conduct subgroup analyses for the primary outcome by time to treatment, type of delivery and cause of haemorrhage. We will conduct an analysis of treatment effect adjusted for baseline risk. The World Maternal Antifibrinolytic trial should provide reliable evidence for the efficacy of tranexamic acid in the prevention of death, hysterectomy and other outcomes that are important to patients. We present a protocol update and the statistical analysis plan for the trial. Current Controlled Trials ISRCTN76912190 (Registration date 08 December 2008), Clinicaltrials.gov NCT00872469 (Registration date 30 March 2009) and Pan African Clinical Trials Registry: PACTR201007000192283 (Registration date 02 September 2010).

40 CFR 265.118 - Post-closure plan; amendment of plan.

Code of Federal Regulations, 2014 CFR

2014-07-01

...: (i) Changes in operating plans or facility design affect the post-closure plan, or (ii) Events which... operation, or no later than 60 days after an unexpected event has occurred which has affected the post... operation, or no more than 60 days after an unexpected event has occurred which has affected the post...

40 CFR 265.118 - Post-closure plan; amendment of plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

...: (i) Changes in operating plans or facility design affect the post-closure plan, or (ii) Events which... operation, or no later than 60 days after an unexpected event has occurred which has affected the post... operation, or no more than 60 days after an unexpected event has occurred which has affected the post...

Depressive vulnerabilities predict depression status and trajectories of depression over 1 year in persons with acute coronary syndrome.

PubMed

Doyle, Frank; McGee, Hannah; Delaney, Mary; Motterlini, Nicola; Conroy, Ronán

2011-01-01

Depression is prevalent in patients hospitalized with acute coronary syndrome (ACS). We determined whether theoretical vulnerabilities for depression (interpersonal life events, reinforcing events, cognitive distortions, Type D personality) predicted depression, or depression trajectories, post-hospitalization. We followed 375 ACS patients who completed depression scales during hospital admission and at least once during three follow-up intervals over 1 year (949 observations). Questionnaires assessing vulnerabilities were completed at baseline. Logistic regression for panel/longitudinal data predicted depression status during follow-up. Latent class analysis determined depression trajectories. Multinomial logistic regression modeled the relationship between vulnerabilities and trajectories. Vulnerabilities predicted depression status over time in univariate and multivariate analysis, even when controlling for baseline depression. Proportions in each depression trajectory category were as follows: persistent (15%), subthreshold (37%), never depressed (48%). Vulnerabilities independently predicted each of these trajectories, with effect sizes significantly highest for the persistent depression group. Self-reported vulnerabilities - stressful life events, reduced reinforcing events, cognitive distortions, personality - measured during hospitalization can identify those at risk for depression post-ACS and especially those with persistent depressive episodes. Interventions should focus on these vulnerabilities. Copyright © 2011 Elsevier Inc. All rights reserved.

Social media for arthritis-related comparative effectiveness and safety research and the impact of direct-to-consumer advertising.

PubMed

Curtis, Jeffrey R; Chen, Lang; Higginbotham, Phillip; Nowell, W Benjamin; Gal-Levy, Ronit; Willig, James; Safford, Monika; Coe, Joseph; O'Hara, Kaitlin; Sa'adon, Roee

2017-03-07

Social media may complement traditional data sources to answer comparative effectiveness/safety questions after medication licensure. The Treato platform was used to analyze all publicly available social media data including Facebook, blogs, and discussion boards for posts mentioning inflammatory arthritis (e.g. rheumatoid, psoriatic). Safety events were self-reported by patients and mapped to medical ontologies, resolving synonyms. Disease and symptom-related treatment indications were manually redacted. The units of analysis were unique terms in posts. Pre-specified conditions (e.g. herpes zoster (HZ)) were selected based upon safety signals from clinical trials and reported as pairwise odds ratios (ORs); drugs were compared with Fisher's exact test. Empirically identified events were analyzed using disproportionality analysis and reported as relative reporting ratios (RRRs). The accuracy of a natural language processing (NLP) classifier to identify cases of shingles associated with arthritis medications was assessed. As of October 2015, there were 785,656 arthritis-related posts. Posts were predominantly US posts (75%) from patient authors (87%) under 40 years of age (61%). For HZ posts (n = 1815), ORs were significantly increased with tofacitinib versus other rheumatoid arthritis therapies. ORs for mentions of perforated bowel (n = 13) were higher with tocilizumab versus other therapies. RRRs associated with tofacitinib were highest in conditions related to baldness and hair regrowth, infections and cancer. The NLP classifier had a positive predictive value of 91% to identify HZ. There was a threefold increase in posts following television direct-to-consumer advertisement (p = 0.04); posts expressing medication safety concerns were significantly more frequent than favorable posts. Social media is a challenging yet promising data source that may complement traditional approaches for comparative effectiveness research for new medications.

Winter maintenance performance measure.

DOT National Transportation Integrated Search

2016-01-01

The Winter Performance Index is a method of quantifying winter storm events and the DOTs response to them. : It is a valuable tool for evaluating the States maintenance practices, performing post-storm analysis, training : maintenance personnel...

Psycho-Social Study of Outstanding Female Athletes

ERIC Educational Resources Information Center

Balazs, Eva K.

1975-01-01

This was an ex post facto analysis of the life histories of 24 Olympic female champions to determine events and variables in the psychological and social driving forces behind outstanding achievement in sports. (RC)

A statistical study of CME-Preflare associated events

NASA Astrophysics Data System (ADS)

Mawad, Ramy; Youssef, M.

2018-07-01

We investigated the relationship of associated CME-Preflare during the solar period 1996-2010. We found 292 CME-Preflare associated events (∼2%). Those associated events have 0-1 h interval time, popular events occur within half an hour before flare starting time. Post-flares-CME associated events are wider than CME-Preflare associated events. CME-Preflare associated events are ejected from the northern hemisphere during the solar cycle 23rd, while the non-associated CMEs are ejected from the southern hemisphere. Polar CME-Preflare associated events are more energetic than the equatorial events. This means that post-flare-CME associated events are more decelerated than CME-Preflare associated events, CME-Flare associated simultaneously events and other CMEs. The CME-Preflare associated events are slower than the post-flare-CME associated events, and slightly faster than non-associated CME events. Post-flare-CME associated events are in average more massive than Preflare CME associated events and all other CMEs ejected from the Sun. CME-Preflare associated has a mean average speed which is equivalent to the mean average solar wind speed approximately.

Surface Deformation Associated with the 1983 Borah Peak Earthquake Measured from Digital Surface Model Differencing

NASA Astrophysics Data System (ADS)

Reitman, N. G.; Briggs, R.; Gold, R. D.; DuRoss, C. B.

2015-12-01

Post-earthquake, field-based assessments of surface displacement commonly underestimate offsets observed with remote sensing techniques (e.g., InSAR, image cross-correlation) because they fail to capture the total deformation field. Modern earthquakes are readily characterized by comparing pre- and post-event remote sensing data, but historical earthquakes often lack pre-event data. To overcome this challenge, we use historical aerial photographs to derive pre-event digital surface models (DSMs), which we compare to modern, post-event DSMs. Our case study focuses on resolving on- and off-fault deformation along the Lost River fault that accompanied the 1983 M6.9 Borah Peak, Idaho, normal-faulting earthquake. We use 343 aerial images from 1952-1966 and vertical control points selected from National Geodetic Survey benchmarks measured prior to 1983 to construct a pre-event point cloud (average ~ 0.25 pts/m2) and corresponding DSM. The post-event point cloud (average ~ 1 pt/m2) and corresponding DSM are derived from WorldView 1 and 2 scenes processed with NASA's Ames Stereo Pipeline. The point clouds and DSMs are coregistered using vertical control points, an iterative closest point algorithm, and a DSM coregistration algorithm. Preliminary results of differencing the coregistered DSMs reveal a signal spanning the surface rupture that is consistent with tectonic displacement. Ongoing work is focused on quantifying the significance of this signal and error analysis. We expect this technique to yield a more complete understanding of on- and off-fault deformation patterns associated with the Borah Peak earthquake along the Lost River fault and to help improve assessments of surface deformation for other historical ruptures.

Cardiovascular Events Following Smoke-Free Legislations: An Updated Systematic Review and Meta-Analysis

PubMed Central

Jones, Miranda R.; Barnoya, Joaquin; Stranges, Saverio; Losonczy, Lia; Navas-Acien, Ana

2014-01-01

Background Legislations banning smoking in indoor public places and workplaces are being implemented worldwide to protect the population from secondhand smoke exposure. Several studies have reported reductions in hospitalizations for acute coronary events following the enactment of smoke-free laws. Objective We set out to conduct a systematic review and meta-analysis of epidemiologic studies examining how legislations that ban smoking in indoor public places impact the risk of acute coronary events. Methods We searched MEDLINE, EMBASE, and relevant bibliographies including previous systematic reviews for studies that evaluated changes in acute coronary events, following implementation of smoke-free legislations. Studies were identified through December 2013. We pooled relative risk (RR) estimates for acute coronary events comparing post- vs. pre-legislation using inverse-variance weighted random-effects models. Results Thirty-one studies providing estimates for 47 locations were included. The legislations were implemented between 1991 and 2010. Following the enactment of smoke-free legislations, there was a 12 % reduction in hospitalizations for acute coronary events (pooled RR: 0.88, 95 % CI: 0.85–0.90). Reductions were 14 % in locations that implemented comprehensive legislations compared to an 8 % reduction in locations that only had partial restrictions. In locations with reductions in smoking prevalence post-legislation above the mean (2.1 % reduction) there was a 14 % reduction in events compared to 10 % in locations below the mean. The RRs for acute coronary events associated with enacting smoke-free legislation were 0.87 vs. 0.89 in locations with smoking prevalence pre-legislation above and below the mean (23.1 %), and 0.87 vs. 0.89 in studies from the Americas vs. other regions. Conclusion The implementation of smoke-free legislations was related to reductions in acute coronary event hospitalizations in most populations evaluated. Benefits are greater in locations with comprehensive legislations and with greater reduction in smoking prevalence post-legislation. These cardiovascular benefits reinforce the urgent need to enact and enforce smoke-free legislations that protect all citizens around the world from exposure to tobacco smoke in public places. PMID:25328861

Adenosine Diphosphate-Induced Platelet-Fibrin Clot Strength: A New Thrombelastographic Indicator of Long-Term Post-Stenting Ischemic Events

PubMed Central

Gurbel, Paul A.; Bliden, Kevin P.; Navickas, Irene A.; Mahla, Elizabeth; Dichiara, Joseph; Suarez, Thomas A.; Antonino, Mark J.; Tantry, Udaya S.; Cohen, Eli

2010-01-01

Background Post-stenting ischemic events occur despite dual antiplatelet therapy suggesting that a “one size fits all” antithrombotic strategy has significant limitations. Ex vivo platelet function measurements may facilitate risk stratification and personalized antiplatelet therapy. Methods We investigated the prognostic utility of the strength of ADP-induced (MAADP) and thrombin-induced (MATHROMBIN) platelet-fibrin clots measured by thrombelastography and ADP-induced light transmittance aggregation (LTAADP) in 225 serial patients following elective stenting treated with aspirin and clopidogrel. Ischemic and bleeding events were assessed over three-years. Results Overall, 59 (26 %) first ischemic events occurred. Patients with ischemic events had higher MAADP, MATHROMBIN, and LTAADP (p<0.0001 for all comparisons). By receiver operating characteristic curve analysis, MAADP > 47mm had the best predictive value of long-term ischemic events compared to other measurements (p<0.0001) with an area under the curve = 0.84 [95% CI 0.78 – 0.89, p < 0.0001]. The univariate Cox proportional hazards model identified MAADP >47mm, MATHROMBIN >69mm, and LTA ADP >34% as significant independent predictors of first ischemic events at the three-year time point, with hazard ratios of 10.3 (p<0.0001), 3.8 (p<0.0001), and 4.8 (p<0.0001) respectively. Fifteen bleeding events occurred. Receiver operator characteristic curve and quartile analysis suggest MAADP ≤ 31 as a predictive value for bleeding. Conclusion This study is the first demonstration of the prognostic utility of MAADP in predicting long term event occurrence following stenting. The quantitative assessment of ADP-stimulated platelet-fibrin clot strength measured by thrombelastography can serve as a future tool in investigations of personalized antiplatelet treatment designed to reduce ischemic events and bleeding. PMID:20691842

Adverse Events following 12 and 18 Month Vaccinations: a Population-Based, Self-Controlled Case Series Analysis

PubMed Central

Wilson, Kumanan; Hawken, Steven; Kwong, Jeffrey C.; Deeks, Shelley; Crowcroft, Natasha S.; Van Walraven, Carl; Potter, Beth K.; Chakraborty, Pranesh; Keelan, Jennifer; Pluscauskas, Michael; Manuel, Doug

2011-01-01

Background Live vaccines have distinct safety profiles, potentially causing systemic reactions one to 2 weeks after administration. In the province of Ontario, Canada, live MMR vaccine is currently recommended at age 12 months and 18 months. Methods Using the self-controlled case series design we examined 271,495 12 month vaccinations and 184,312 18 month vaccinations to examine the relative incidence of the composite endpoint of emergency room visits or hospital admissions in consecutive one day intervals following vaccination. These were compared to a control period 20 to 28 days later. In a post-hoc analysis we examined the reasons for emergency room visits and the average acuity score at presentation for children during the at-risk period following the 12 month vaccine. Results Four to 12 days post 12 month vaccination, children had a 1.33 (1.29–1.38) increased relative incidence of the combined endpoint compared to the control period, or at least one event during the risk interval for every 168 children vaccinated. Ten to 12 days post 18 month vaccination, the relative incidence was 1.25 (95%, 1.17–1.33) which represented at least one excess event for every 730 children vaccinated. The primary reason for increased events was statistically significant elevations in emergency room visits following all vaccinations. There were non-significant increases in hospital admissions. There were an additional 20 febrile seizures for every 100,000 vaccinated at 12 months. Conclusions There are significantly elevated risks of primarily emergency room visits approximately one to two weeks following 12 and 18 month vaccination. Future studies should examine whether these events could be predicted or prevented. PMID:22174753

Risk of Death in Infants Who Have Experienced a Brief Resolved Unexplained Event: A Meta-Analysis.

PubMed

Brand, Donald A; Fazzari, Melissa J

2018-06-01

To estimate an upper bound on the risk of death after a brief resolved unexplained event (BRUE), a sudden alteration in an infant's breathing, color, tone, or responsiveness, previously labeled "apparent life-threatening event" (ALTE). The meta-analysis incorporated observational studies of patients with ALTE that included data on in-hospital and post-discharge deaths with at least 1 week of follow-up after hospital discharge. Pertinent studies were identified from a published review of the literature from 1970 through 2014 and a supplementary PubMed query through February 2017. The 12 included studies (n = 3005) reported 12 deaths, of which 8 occurred within 4 months of the event. Applying a Poisson-normal random effects model to the 8 proximate deaths using a 4-month time horizon yielded a post-ALTE mortality rate of about 1 in 800, which constitutes an upper bound on the risk of death after a BRUE. This risk is about the same as the baseline risk of death during the first year of life. The meta-analysis therefore supports the return-home approach advocated in a recently published clinical practice guideline-not routine hospitalization-for BRUE patients who have been evaluated in the emergency department and determined to be at lower risk. Copyright © 2017 Elsevier Inc. All rights reserved.

Peroral endoscopic myotomy for the treatment of esophageal achalasia: systematic review and pooled analysis.

PubMed

Patel, K; Abbassi-Ghadi, N; Markar, S; Kumar, S; Jethwa, P; Zaninotto, G

2016-10-01

Peroral endoscopic myotomy (POEM) is a novel approach to performing esophageal myotomy for the treatment of achalasia. This review aims to assess subjective and objective metrics of achalasia treatment efficacy, perioperative adverse events and the incidence of postoperative gastroesophageal reflux disease in patients treated with POEM. Secondary aims include a pooled analysis comparison of the clinical outcomes and procedural safety of POEM versus laparoscopic Heller's myotomy (LHM). A systematic review of the literature, up to and including January 15, 2015, was conducted for studies reporting POEM outcomes. Studies comparing POEM to LHM were also included for the purpose of pooled analysis. Outcomes from 1122 POEM patients, from 22 studies, are reported in this systematic review. Minor operative adverse events included capno/pneumo-peritoneum (30.6%), capno/pneumo-thorax (11.0%) and subcutaneous emphysema (31.6%). Major operative adverse events included mediastinal leak (0.3%), postoperative bleeding (1.1%) and a single mortality (0.09%). There was an improvement in lower esophageal sphincter pressure and timed barium esophagram column height of 66% and 80% post-POEM, respectively. Symptom improvement was demonstrated with a pre- and post-POEM Eckardt score ± standard deviation of 6.8 ± 1.0 and 1.2 ± 0.6, respectively. Pre- and post-POEM endoscopy showed esophagitis in 0% and 19% of patients, respectively. The median (interquartile range) points scored for study quality was 15 (14-16) out of total of 32. Pooled analysis of three comparative studies between LHM and POEM showed similar results for adverse events, perforation rate, operative time and a nonsignificant trend toward a reduced length of hospital stay in the POEM group. In conclusion, POEM is a safe and effective treatment for achalasia, showing significant improvements in objective metrics and achalasia-related symptoms. Randomized comparative studies of LHM and POEM are required to determine the most effective treatment modality for achalasia. © 2015 International Society for Diseases of the Esophagus.

Analyzing depression tendency of web posts using an event-driven depression tendency warning model.

PubMed

Tung, Chiaming; Lu, Wenhsiang

2016-01-01

The Internet has become a platform to express individual moods/feelings of daily life, where authors share their thoughts in web blogs, micro-blogs, forums, bulletin board systems or other media. In this work, we investigate text-mining technology to analyze and predict the depression tendency of web posts. In this paper, we defined depression factors, which include negative events, negative emotions, symptoms, and negative thoughts from web posts. We proposed an enhanced event extraction (E3) method to automatically extract negative event terms. In addition, we also proposed an event-driven depression tendency warning (EDDTW) model to predict the depression tendency of web bloggers or post authors by analyzing their posted articles. We compare the performance among the proposed EDDTW model, negative emotion evaluation (NEE) model, and the diagnostic and statistical manual of mental disorders-based depression tendency evaluation method. The EDDTW model obtains the best recall rate and F-measure at 0.668 and 0.624, respectively, while the diagnostic and statistical manual of mental disorders-based method achieves the best precision rate of 0.666. The main reason is that our enhanced event extraction method can increase recall rate by enlarging the negative event lexicon at the expense of precision. Our EDDTW model can also be used to track the change or trend of depression tendency for each post author. The depression tendency trend can help doctors to diagnose and even track depression of web post authors more efficiently. This paper presents an E3 method to automatically extract negative event terms in web posts. We also proposed a new EDDTW model to predict the depression tendency of web posts and possibly help bloggers or post authors to early detect major depressive disorder. Copyright © 2015 Elsevier B.V. All rights reserved.

Snow Tweets: Emergency Information Dissemination in a US County During 2014 Winter Storms

PubMed Central

Bonnan-White, Jess; Shulman, Jason; Bielecke, Abigail

2014-01-01

Introduction: This paper describes how American federal, state, and local organizations created, sourced, and disseminated emergency information via social media in preparation for several winter storms in one county in the state of New Jersey (USA). Methods: Postings submitted to Twitter for three winter storm periods were collected from selected organizations, along with a purposeful sample of select private local users. Storm-related posts were analyzed for stylistic features (hashtags, retweet mentions, embedded URLs). Sharing and re-tweeting patterns were also mapped using NodeXL. Results: Results indicate emergency management entities were active in providing preparedness and response information during the selected winter weather events. A large number of posts, however, did not include unique Twitter features that maximize dissemination and discovery by users. Visual representations of interactions illustrate opportunities for developing stronger relationships among agencies. Discussion: Whereas previous research predominantly focuses on large-scale national or international disaster contexts, the current study instead provides needed analysis in a small-scale context. With practice during localized events like extreme weather, effective information dissemination in large events can be enhanced. PMID:25685629

Snow Tweets: Emergency Information Dissemination in a US County During 2014 Winter Storms.

PubMed

Bonnan-White, Jess; Shulman, Jason; Bielecke, Abigail

2014-12-22

This paper describes how American federal, state, and local organizations created, sourced, and disseminated emergency information via social media in preparation for several winter storms in one county in the state of New Jersey (USA). Postings submitted to Twitter for three winter storm periods were collected from selected organizations, along with a purposeful sample of select private local users. Storm-related posts were analyzed for stylistic features (hashtags, retweet mentions, embedded URLs). Sharing and re-tweeting patterns were also mapped using NodeXL. RESULTS indicate emergency management entities were active in providing preparedness and response information during the selected winter weather events. A large number of posts, however, did not include unique Twitter features that maximize dissemination and discovery by users. Visual representations of interactions illustrate opportunities for developing stronger relationships among agencies. Whereas previous research predominantly focuses on large-scale national or international disaster contexts, the current study instead provides needed analysis in a small-scale context. With practice during localized events like extreme weather, effective information dissemination in large events can be enhanced.

Suggestibility and state anxiety: how the two concepts relate in a source identification paradigm.

PubMed

Ridley, Anne M; Clifford, Brian R

2006-01-01

Source identification tests provide a stringent method for testing the suggestibility of memory because they reduce response bias and experimental demand characteristics. Using the techniques and materials of Maria Zaragoza and her colleagues, we investigated how state anxiety affects the ability of undergraduates to identify correctly the source of misleading post-event information. The results showed that individuals high in state anxiety were less likely to make source misattributions of misleading information, indicating lower levels of suggestibility. This effect was strengthened when forgotten or non-recognised misleading items (for which a source identification task is not possible) were excluded from the analysis. Confidence in the correct attribution of misleading post-event information to its source was significantly less than confidence in source misattributions. Participants who were high in state anxiety tended to be less confident than those lower in state anxiety when they correctly identified the source of both misleading post-event information and non-misled items. The implications of these findings are discussed, drawing on the literature on anxiety and cognition as well as suggestibility.

Traumatic Life Events and Psychopathology in a High Risk, Ethnically Diverse Sample of Young Children: A Person-Centered Approach.

PubMed

Hagan, Melissa J; Sulik, Michael J; Lieberman, Alicia F

2016-07-01

Studies of the association between traumatic experiences and psychopathology in early childhood have primarily focused on specific types of events (e.g., sexual abuse) or aggregated different types of events without differentiating among them. We extend this body of work by investigating patterns of traumatic event exposure in a high-risk, ethnically diverse sample of children ages 3-6 (N = 211; 51 % female) and relating these different patterns to parents' reports of child externalizing, internalizing, and post-traumatic stress symptomatology. Using latent class analysis, which divides a heterogeneous population into homogenous subpopulations, we identified three patterns of traumatic events based on parents' responses to an interview-based assessment of trauma exposure in young children: (1) severe exposure, characterized by a combination of family violence and victimization; (2) witnessing family violence without victimization; and (3) moderate exposure, characterized by an absence of family violence but a moderate probability of other events. The severe exposure class exhibited elevated internalizing and post-traumatic stress symptoms relative to the witness to violence and moderate exposure classes, controlling for average number of traumatic events. Results highlight the need for differentiation between profiles of traumatic life event exposure and the potential for person-centered methods to complement the cumulative risk perspective.

Automation of Physiologic Data Presentation and Alarms in the Post Anesthesia Care Unit

PubMed Central

Aukburg, S.J.; Ketikidis, P.H.; Kitz, D.S.; Mavrides, T.G.; Matschinsky, B.B.

1989-01-01

The routine use of pulse oximeters, non-invasive blood pressure monitors and electrocardiogram monitors have considerably improved patient care in the post anesthesia period. Using an automated data collection system, we investigated the occurrence of several adverse events frequently revealed by these monitors. We found that the incidence of hypoxia was 35%, hypertension 12%, hypotension 8%, tachycardia 25% and bradycardia 1%. Discriminant analysis was able to correctly predict classification of about 90% of patients into normal vs. hypotensive or hypotensive groups. The system software minimizes artifact, validates data for epidemiologic studies, and is able to identify variables that predict adverse events through application of appropriate statistical and artificial intelligence techniques.

Mediators of the relationship between social anxiety and post-event rumination.

PubMed

Chen, Junwen; Rapee, Ronald M; Abbott, Maree J

2013-01-01

A variety of cognitive and attentional factors are hypothesised to be associated with post-event rumination, a key construct that has been proposed to contribute to the maintenance of social anxiety disorder (SAD). The present study aimed to explore factors contributing to post-event rumination following delivery of a speech in a clinical population. 121 participants with SAD completed measures of trait social anxiety a week before they undertook a speech task. After the speech, participants answered several questionnaires assessing their state anxiety, self-evaluation of performance, perceived focus of attention and probability and cost of expected negative evaluation. One-week later, participants completed measures of negative rumination experienced over the week. Results showed two pathways leading to post-event rumination: (1) a direct path from trait social anxiety to post-event rumination and (2) indirect paths from trait social anxiety to post-event rumination via its relationships with inappropriate attentional focus and self-evaluation of performance. The results suggest that post event rumination is at least partly predicted by the extent to which socially anxious individuals negatively perceive their own performance and their allocation of attentional resources to this negative self-image. Current findings support the key relationships among cognitive processes proposed by cognitive models. Copyright © 2012 Elsevier Ltd. All rights reserved.

National Centers for Environmental Prediction

Science.gov Websites

Modeling Mesoscale Modeling Marine Modeling and Analysis Teams Climate Data Assimilation Ensembles and Post Contacts Change Log Events Calendar Numerical Forecast Systems NCEP Model Analysis and Guidance Page [< Modeling Center NOAA Center for Weather and Climate Prediction (NCWCP) 5830 University Research Court

Naturalizing the Future in Factual Discourse: A Critical Linguistic Analysis of a Projected Event.

ERIC Educational Resources Information Center

Dunmire, Patricia L.

1997-01-01

Examines the linguistic processes through which a projected effect is constructed within factual discourse. Applies critical linguistic analysis to coverage of the 1990 Gulf War in the "New York Times" and "Washington Post." Expands on work in critical linguistics and demonstrates how political interests underlying newspaper…

Identification of unusual events in multichannel bridge monitoring data using wavelet transform and outlier analysis

NASA Astrophysics Data System (ADS)

Omenzetter, Piotr; Brownjohn, James M. W.; Moyo, Pilate

2003-08-01

Continuously operating instrumented structural health monitoring (SHM) systems are becoming a practical alternative to replace visual inspection for assessment of condition and soundness of civil infrastructure. However, converting large amount of data from an SHM system into usable information is a great challenge to which special signal processing techniques must be applied. This study is devoted to identification of abrupt, anomalous and potentially onerous events in the time histories of static, hourly sampled strains recorded by a multi-sensor SHM system installed in a major bridge structure in Singapore and operating continuously for a long time. Such events may result, among other causes, from sudden settlement of foundation, ground movement, excessive traffic load or failure of post-tensioning cables. A method of outlier detection in multivariate data has been applied to the problem of finding and localizing sudden events in the strain data. For sharp discrimination of abrupt strain changes from slowly varying ones wavelet transform has been used. The proposed method has been successfully tested using known events recorded during construction of the bridge, and later effectively used for detection of anomalous post-construction events.

Characterizing Fractures Across the Astronaut Corps: Preliminary Findings from Population-Level Analysis

NASA Technical Reports Server (NTRS)

Rossi, Meredith M.; Charvat, Jacqueline; Sibonga, Jean; Sieker, Jeremy

2017-01-01

Despite evidence of bone loss during spaceflight and operational countermeasures to mitigate this loss, the subsequent risk of fracture among astronauts is not known. The physiologic process of diminished bone density and bone recovery during or following spaceflight is multifactorial. Such factors as age, sex, fracture history, and others may combine to increase fracture risk among astronauts. As part of the 2016 Bone Research and Clinical Advisory Panel (RCAP), the authors analyzed data collected on 338 NASA astronauts to describe the demographics, bone-relevant characteristics, and fracture history of the astronaut population. The majority of the population are male (n=286, 84.6%), have flown at least one mission (n=306, 90.5%), and were between the ages of 30 and 49 at first mission (n=296, 96.7% of those with at least one mission). Of the 338 astronauts, 241 (71.3%) experienced a fracture over the course of their lifetime. One hundred and five (43.5%) of these 241 astronauts only experienced a fracture prior to being selected into the Astronaut Corps, whereas 53 (22.0%) only experienced a fracture after selection as an astronaut. An additional 80 astronauts (33.2%) had both pre- and post-selection fractures. The remaining 3 astronauts had a fracture of unknown date, which could not be categorized as pre- or post-selection. Among the 133 astronauts with at least one post-selection fracture, males comprised 90.2% (n=120) compared to 84.5% of the entire Corps, and females accounted for 9.8% (n=13) compared to 15.4% of the Corps. Ninety-seven of the 133 astronauts with post-selection fractures (72.9%) had one fracture event, 22 (16.5%) had two fractures, and 14 (10.5%) had three or more fractures. Some astronauts with multiple fractures suffered these in a single event, such as an automobile accident. The 133 astronauts with a post-selection fracture accounted for a total of 188 fracture events. One hundred and four (78.2%) of astronauts with post-selection fractures experienced those fractures following their first mission (mean 12.7 +/- 11.1 years following first mission; range 14.0 days - 50.6 years). Additional analyses are ongoing and include examination of fracture history, skeletal site, mechanism, and type of fracture, age at time of fracture, time from spaceflight to fracture, as well as multivariable analysis comparing fracture events to non-events. The results of such analyses may reveal trends in risk factors for fracture among the astronaut corps that have yet to be systematically described through a corps-wide approach.

Post-event processing in social anxiety.

PubMed

Dannahy, Laura; Stopa, Lusia

2007-06-01

Clark and Wells' [1995. A cognitive model of social phobia. In: R. Heimberg, M. Liebowitz, D.A. Hope, & F.R. Schneier (Eds.) Social phobia: Diagnosis, assessment and treatment (pp. 69-93). New York: Guildford Press.] cognitive model of social phobia proposes that following a social event, individuals with social phobia will engage in post-event processing, during which they conduct a detailed review of the event. This study investigated the relationship between self-appraisals of performance and post-event processing in individuals high and low in social anxiety. Participants appraised their performance immediately after a conversation with an unknown individual and prior to an anticipated second conversation task 1 week later. The frequency and valence of post-event processing during the week following the conversation was also assessed. The study also explored differences in the metacognitive processes of high and low socially anxious participants. The high socially anxious group experienced more anxiety, predicted worse performance, underestimated their actual performance, and engaged in more post-event processing than low socially anxious participants. The degree of negative post-event processing was linked to the extent of social anxiety and negative appraisals of performance, both immediately after the conversation task and 1 week later. Differences were also observed in some metacognitive processes. The results are discussed in relation to current theory and previous research.

Prevalence of Inadequate Blood Pressure Control Among Veterans After Acute Ischemic Stroke Hospitalization: A Retrospective Cohort

PubMed Central

Roumie, Christianne L.; Ofner, Susan; Ross, Joseph S.; Arling, Greg; Williams, Linda S.; Ordin, Diana L.; Bravata, Dawn M.

2011-01-01

Background Reducing blood pressure (BP) after stroke reduces risk for recurrent events. Our aim was to describe hypertension care among veterans with ischemic stroke including BP control by discharge and over the 6 months post stroke event. Methods and Results The Office of Quality and Performance Stroke Special Study included a systematic sample of veterans hospitalized for ischemic stroke in 2007. We examined BP control (<140/90 mmHg) at discharge excluding those who died, enrolled in hospice, or had unknown discharge disposition (N=3640, 3382 adjusted analysis). The second outcome was BP control (<140/90 mmHg) within 6-months post-stroke, excluding patients who died /readmitted within 30 days, lost to follow-up or did not have a BP recorded (N=2054, 1915 adjusted analysis). The population was white (62.7 %) and male (97.7%); 46.9% were <65 years of age; 29% and 37% had a history of cerebrovascular or cardiovascular disease, respectively. Among the 3640 stroke patients 1573(43%) had their last documented BP prior to discharge >140/90 mmHg. Black race (adjusted OR 0.77 [95% CI 0.65, 0.91]), diabetes (OR 0.73 [95% CI 0.62, 0.86]) and hypertension history (OR 0.51 [95% CI 0.42, 0.63]) were associated with lower odds for controlled BP at discharge. Of the 2054 stroke patients seen within 6 months from their index event, 673 (32.8%) remained uncontrolled. By 6 months post event, neither race nor diabetes was associated with BP control; whereas history of hypertension continued to have lower odds of BP control. For each 10 point increase in systolic BP > 140 mmHg at discharge, odds of BP control within 6 months post discharge decreased by 12% (95% CI (8%, 18%)). Conclusions BP values in excess of national guidelines are common after stroke. Forty three percent of patients were discharged with an elevated BP and 33% remained uncontrolled by 6 months. PMID:21693725

Compilation of Thesis Abstracts

DTIC Science & Technology

2005-09-01

Special Events Management in the Post-9/11 World...Information Sharing TOWARDS A STRATEGIC APPROACH TO SPECIAL EVENTS MANAGEMENT IN THE POST-9/11 WORLD G.B. Jones-Chief, FBI Special Events Management Unit...counterterrorism and law enforcement planning for major special events and identifies some of the strategic issues that have emerged in special events management

The Frasnian-Famennian mass killing event(s), methods of identification and evaluation

NASA Technical Reports Server (NTRS)

Geldsetzer, H. H. J.

1988-01-01

The absence of an abnormally high number of earlier Devonian taxa from Famennian sediments was repeatedly documented and can hardly be questioned. Primary recognition of the event(s) was based on paleontological data, especially common macrofossils. Most paleontologists place the disappearance of these common forms at the gigas/triangularis contact and this boundary was recently proposed as the Frasnian-Famennian (F-F) boundary. Not unexpectedly, alternate F-F positions were suggested caused by temporary Frasnian survivors or sudden post-event radiations of new forms. Secondary supporting evidence for mass killing event(s) is supplied by trace element and stable isotope geochemistry but not with the same success as for the K/T boundary, probably due to additional 300 ma of tectonic and diagenetic overprinting. Another tool is microfacies analysis which is surprisingly rarely used even though it can explain geochemical anomalies or paleontological overlap not detectable by conventional macrofacies analysis. The combination of microfacies analysis and geochemistry was applied at two F-F sections in western Canada and showed how interdependent the two methods are. Additional F-F sections from western Canada, western United States, France, Germany and Australia were sampled or re-sampled and await geochemical/microfacies evaluation.

Inhospital and Post-discharge Changes in Renal Function After Transcatheter Aortic Valve Replacement.

PubMed

Blair, John E A; Brummel, Kent; Friedman, Julie L; Atri, Prashant; Sweis, Ranya N; Russell, Hyde; Ricciardi, Mark J; Malaisrie, S Chris; Davidson, Charles J; Flaherty, James D

2016-02-15

The aim of this study was to determine the influence of inhospital and post-discharge worsening renal function (WRF) on prognosis after transcatheter aortic valve replacement (TAVR). Severe chronic kidney disease and inhospital WRF are both associated with poor outcomes after TAVR. There are no data available on post-discharge WRF and outcomes. This was a single-center study evaluating all TAVR from June 1, 2008, to June 31, 2014. WRF was defined as an increase in serum creatinine of ≥0.3 mg/dl. Inhospital WRF was measured from day 0 until discharge or day 7 if the hospitalization was >7 days. Post-discharge WRF was measured at 30 days after discharge. Descriptive statistics, Kaplan-Meier time-to-event analysis, and multivariate logistic regression were used. In a series of 208 patients who underwent TAVR, 204 with complete renal function data were used in the inhospital analysis and 168 who returned for the 30-day follow-up were used in the post-discharge analysis. Inhospital WRF was seen in 28%, whereas post-discharge WRF in 12%. Inhospital and post-discharge WRF were associated with lower rates of survival; however, after multivariate analysis, only post-discharge WRF remained a predictor of 1-year mortality (hazard ratio 1.18, p = 0.030 for every 1 mg/dl increase in serum creatinine). In conclusion, the rate of inhospital WRF is higher than the rate of post-discharge WRF after TAVR, and post-discharge WRF is more predictive of mortality than inhospital WRF. Copyright © 2016 Elsevier Inc. All rights reserved.

Statistical Analysis of Interchange Injection Events from Over a Decade of Cassini Data

NASA Astrophysics Data System (ADS)

Azari, A.; Jia, X.; Liemohn, M. W.; Sergis, N.; Thomsen, M. F.; Mitchell, D. G.; Rymer, A. M.; Paranicas, C.; Provan, G.; Ye, S.; Cowley, S. W. H.; Hospodarsky, G. B.; Vandegriff, J. D.; Kurth, W. S.

2017-12-01

The Cassini spacecraft has routinely observed interchange injection events with multiple instruments since arriving at Saturn in 2004. Interchange injection events are thought to initiate from a Rayleigh-Taylor like plasma instability sourced from Saturn's rapid rotation (period 10.8 hours) and dense plasma population outgassing primarily from Enceladus, and are the primary source of mass transport in the inner/middle magnetosphere. This dense plasma must be transported outward, and to conserve magnetic flux, inward moving flux tubes of low density, energetic (> keV) plasma from the outer reaches of the Saturnian system also occur. These inward-bound flux tubes are referred to as interchange injections. We will present a statistical evaluation of the occurrence rates of interchange injections at Saturn demonstrating seasonal dependence of interchange over the entirety of the Cassini mission's equatorial orbits between 2005 and 2016. We identify interchange events from CHarge Energy Mass Spectrometer (CHEMS) H+ data using a trained and tested automated algorithm. Our event identification compares well with manual identification and previous surveys of injections by L-shell and local time (Chen and Hill, 2008, Lai et al., 2016, Kennelly et al., 2013). We find that peak rates of interchange events occur between 7 - 9 Saturn radii, in agreement with previous surveys. We also evaluate interchange by preferred local time sector and season, splitting our events into pre-equinox, equinox, and post - equinox time periods. We determine that over all seasons, nightside occurrence dominated as compared to dayside, but the preferred dayside sector shifts from pre-noon during equinox, to post-noon during post-equinox. We will further investigate seasonal dependence by presenting occurrence organized by the phase systems derived based on Saturn kilometric radiation (SKR) and magnetic field perturbations (PPO).

Delayed post-hypoxic leukoencephalopathy: case report with a review of disease pathophysiology.

PubMed

Meyer, Michael Andrew

2013-01-01

Delayed post-hypoxic leukoencephalopathy is a rare clinical phenomenon usually observed in a small number of carbon monoxide poisoning survivors. A similar phenomenon is reported here in a patient who successfully recovered from a large overdose of diazepam and methadone, but then abruptly declined 3 weeks after the initial event. Magnetic resnance revealed confluent white matter hyperintensity on fluid-attenuated inversion recovery and T2 weighted sequences, and spectroscopy revealed elevated peaks in choline, creatinine, and lactate. Analysis and review of the literature suggests this phenomenon occurs on average about 19 days after the initial event. Although the pathophysiology remains obscure, it is noted here that the mean lucid interval coincides approximately with the replacement half-life for myelin related lipids and proteins.

Integration of rainfall/runoff and geomorphological analyses flood hazard in small catchments: case studies from the southern Apennines (Italy)

NASA Astrophysics Data System (ADS)

Palumbo, Manuela; Ascione, Alessandra; Santangelo, Nicoletta; Santo, Antonio

2017-04-01

We present the first results of an analysis of flood hazard in ungauged mountain catchments that are associated with intensely urbanized alluvial fans. Assessment of hydrological hazard has been based on the integration of rainfall/runoff modelling of drainage basins with geomorphological analysis and mapping. Some small and steep, ungauged mountain catchments located in various areas of the southern Apennines, in southern Italy, have been chosen as test sites. In the last centuries, the selected basins have been subject to heavy and intense precipitation events, which have caused flash floods with serious damages in the correlated alluvial fan areas. Available spatial information (regional technical maps, DEMs, land use maps, geological/lithological maps, orthophotos) and an automated GIS-based procedure (ArcGis tools and ArcHydro tools) have been used to extract morphological, hydrological and hydraulic parameters. Such parameters have been used to run the HEC (Hydrologic Engineering Center of the US Army Corps of Engineers) software (GeoHMS, GeoRAS, HMS and RAS) based on rainfall-runoff models, which have allowed the hydrological and hydraulic simulations. As the floods occurred in the studied catchments have been debris flows dominated, the solid load simulation has been also performed. In order to validate the simulations, we have compared results of the modelling with the effects produced by past floods. Such effects have been quantified through estimations of both the sediment volumes within each catchment that have the potential to be mobilised (pre-event) during a sediment transfer event, and the volume of sediments delivered by the debris flows at basins' outlets (post-event). The post-event sediment volume has been quantified through post-event surveys and Lidar data. Evaluation of the pre-event sediment volumes in single catchments has been based on mapping of sediment storages that may constitute source zones of bed load transport and debris flows. For such an approach has been used a methodology that consists of the application of a process-based geomorphological mapping, based on data derived from GIS analysis using high-resolution DEMs, field measurements and aerial photograph interpretations. Our integrated approach, which allows quantification of the flow rate and a semi-quantitative assessment of sediment that can be mobilized during hydro-meteorological events, is applied for the first time to torrential catchmenmts of the southern Apennines and may significantly contribute to previsional studies aimed at risk mitigation in the study region.

Biophysical Interactions within Step-Pool Mountain Streams Following Wildfire

NASA Astrophysics Data System (ADS)

Parker, A.; Chin, A.; O'Dowd, A. P.

2014-12-01

Recovery of riverine ecosystems following disturbance is driven by a variety of interacting processes. Wildfires pose increasing disturbances to riverine landscapes, with rising frequencies and magnitudes owing to warming climates and increased fuel loads. The effects of wildfire include loss of vegetation, elevated runoff and flash floods, erosion and deposition, and changing biological habitats and communities. Understanding process interactions in post-fire landscapes is increasingly urgent for successful management and restoration of affected ecosystems. In steep channels, steps and pools provide prominent habitats for organisms and structural integrity in high energy environments. Step-pools are typically stable, responding to extreme events with recurrence intervals often exceeding 50 years. Once wildfire occurs, however, intensification of post-fire flood events can potentially overpower the inherent stability of these systems, with significant consequences for aquatic life and human well-being downstream. This study examined the short-term response of step-pool streams following the 2012 Waldo Canyon Fire in Colorado. We explored interacting feedbacks among geomorphology, hydrology, and ecology in the post-fire environment. At selected sites with varying burn severity, we established baseline conditions immediately after the fire with channel surveys, biological assessment using benthic macroinvertebrates, sediment analysis including pebble counts, and precipitation gauging. Repeat measurements after major storm events over several years enabled analysis of the interacting feedbacks among post-fire processes. We found that channels able to retain the step-pool structure changed less and facilitated recovery more readily. Step habitats maintained higher percentages of sensitive macroinvertebrate taxa compared to pools through post-fire floods. Sites burned with high severity experienced greater reduction in the percentage of sensitive taxa. The decimation of macroinvertebrates closely coincides with the physical destruction of the step-pool morphology. The role that step-pools play in enhancing the ecological quality of fluvial systems, therefore, provides a key focus for effective management and restoration of aquatic resources following wildfires.

A pragmatic randomised controlled trial comparing the efficacy of a femoral nerve block and periarticular infiltration for early pain relief following total knee arthroplasty.

PubMed

Wall, P D H; Parsons, N R; Parsons, H; Achten, J; Balasubramanian, S; Thompson, P; Costa, M L

2017-07-01

The aim of this study was to compare the effectiveness of a femoral nerve block and a periarticular infiltration in the management of early post-operative pain after total knee arthroplasty (TKA). A pragmatic, single centre, two arm parallel group, patient blinded, randomised controlled trial was undertaken. All patients due for TKA were eligible. Exclusion criteria included contraindications to the medications involved in the study and patients with a neurological abnormality of the lower limb. Patients received either a femoral nerve block with 75 mg of 0.25% levobupivacaine hydrochloride around the nerve, or periarticular infiltration with 150 mg of 0.25% levobupivacaine hydrochloride, 10 mg morphine sulphate, 30 mg ketorolac trometamol and 0.25 mg of adrenaline all diluted with 0.9% saline to make a volume of 150 ml. A total of 264 patients were recruited and data from 230 (88%) were available for the primary analysis. Intention-to-treat analysis of the primary outcome measure of a visual analogue score for pain on the first post-operative day, prior to physiotherapy, was similar in both groups. The mean difference was -0.7 (95% confidence interval (CI) -5.9 to 4.5; p = 0.834). The periarticular group used less morphine in the first post-operative day compared with the femoral nerve block group (74%, 95% CI 55 to 99). The femoral nerve block group reported 39 adverse events, of which 27 were serious, in 31 patients and the periarticular group reported 51 adverse events, of which 38 were serious, in 42 patients up to six weeks post-operatively. None of the adverse events were directly attributed to either of the interventions under investigation. Periarticular infiltration is a viable and safe alternative to femoral nerve block for the early post-operative relief of pain following TKA. Cite this article: Bone Joint J 2017;99-B:904-11. ©2017 The British Editorial Society of Bone & Joint Surgery.

Experimental annotation of post-translational features and translated coding regions in the pathogen Salmonella Typhimurium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ansong, Charles; Tolic, Nikola; Purvine, Samuel O.

Complete and accurate genome annotation is crucial for comprehensive and systematic studies of biological systems. For example systems biology-oriented genome scale modeling efforts greatly benefit from accurate annotation of protein-coding genes to develop proper functioning models. However, determining protein-coding genes for most new genomes is almost completely performed by inference, using computational predictions with significant documented error rates (> 15%). Furthermore, gene prediction programs provide no information on biologically important post-translational processing events critical for protein function. With the ability to directly measure peptides arising from expressed proteins, mass spectrometry-based proteomics approaches can be used to augment and verify codingmore » regions of a genomic sequence and importantly detect post-translational processing events. In this study we utilized “shotgun” proteomics to guide accurate primary genome annotation of the bacterial pathogen Salmonella Typhimurium 14028 to facilitate a systems-level understanding of Salmonella biology. The data provides protein-level experimental confirmation for 44% of predicted protein-coding genes, suggests revisions to 48 genes assigned incorrect translational start sites, and uncovers 13 non-annotated genes missed by gene prediction programs. We also present a comprehensive analysis of post-translational processing events in Salmonella, revealing a wide range of complex chemical modifications (70 distinct modifications) and confirming more than 130 signal peptide and N-terminal methionine cleavage events in Salmonella. This study highlights several ways in which proteomics data applied during the primary stages of annotation can improve the quality of genome annotations, especially with regards to the annotation of mature protein products.« less

Digital drug safety surveillance: monitoring pharmaceutical products in twitter.

PubMed

Freifeld, Clark C; Brownstein, John S; Menone, Christopher M; Bao, Wenjie; Filice, Ross; Kass-Hout, Taha; Dasgupta, Nabarun

2014-05-01

Traditional adverse event (AE) reporting systems have been slow in adapting to online AE reporting from patients, relying instead on gatekeepers, such as clinicians and drug safety groups, to verify each potential event. In the meantime, increasing numbers of patients have turned to social media to share their experiences with drugs, medical devices, and vaccines. The aim of the study was to evaluate the level of concordance between Twitter posts mentioning AE-like reactions and spontaneous reports received by a regulatory agency. We collected public English-language Twitter posts mentioning 23 medical products from 1 November 2012 through 31 May 2013. Data were filtered using a semi-automated process to identify posts with resemblance to AEs (Proto-AEs). A dictionary was developed to translate Internet vernacular to a standardized regulatory ontology for analysis (MedDRA(®)). Aggregated frequency of identified product-event pairs was then compared with data from the public FDA Adverse Event Reporting System (FAERS) by System Organ Class (SOC). Of the 6.9 million Twitter posts collected, 4,401 Proto-AEs were identified out of 60,000 examined. Automated, dictionary-based symptom classification had 86 % recall and 72 % precision [corrected]. Similar overall distribution profiles were observed, with Spearman rank correlation rho of 0.75 (p < 0.0001) between Proto-AEs reported in Twitter and FAERS by SOC. Patients reporting AEs on Twitter showed a range of sophistication when describing their experience. Despite the public availability of these data, their appropriate role in pharmacovigilance has not been established. Additional work is needed to improve data acquisition and automation.

Post-traumatic stress disorder among survivors two years after the 2010 Mount Merapi volcano eruption: A survey study.

PubMed

Warsini, Sri; Buettner, Petra; Mills, Jane; West, Caryn; Usher, Kim

2015-06-01

The Mount Merapi volcanic eruption in October 2010 was one of Indonesia's largest and most recent natural disasters. A cross-sectional study was undertaken to measure the psychosocial impact of the eruption on survivors in two locations in Yogyakarta, Java, Indonesia. The Impact of Event Scale Revised was used to assess participants' symptoms of post-traumatic stress disorder. Post-Traumatic Stress Disorder responses and demographic characteristics were compared in both locations by conducting bivariate analysis using Mann-Whitney and t tests. The relative contributions of demographic variables and psychosocial impact were examined using multiple linear regression analyses. Two years after the eruption, survivors from the area closest to the eruption had significantly higher Impact of Event Scale Revised scores than those in the comparison area. In particular, females, adults between the ages of 18 and 59, and people who owned their own home experienced the highest levels of psychosocial impact. Nurses and other health professionals need to be aware of the impact of natural disasters on survivors and develop interventions to help people adjust to the psychosocial impact of these events. © 2014 Wiley Publishing Asia Pty Ltd.

[Rancidness of Armeniacae Semen Amarum involving Bianzhuang Lunzhi].

PubMed

Gong, Jian-Ting; Zhao, Li-Ying; Rudolf, Bauer; Mi, Wen-Juan; Li, Yang; Li, Jia-Hui; Ren, Zhi-Yu; Xu, Dong; Zhao, Ting; Yan, Yong-Hong

2016-12-01

This article aims to compare the qualities of Armeniacae Semen Amarum before and after rancidness, in order to study the rancidness of Armeniacae Semen Amarum. In the experiment, content of fatty oil, acid value and peroxide value were determined before and after rancidness,respectively. Meanwhile, HPLC, GC-MS were utilized to analyze laetrile and fatty acid components. Besides, colorimeter and e-nose were introduced to quantify and compare "color and odor". A correlation analysis was conducted on the above results. The results showed that color of post-rancidness Armeniacae Semen Amarum changed from yellow to brown, with sour and lower content of laetrile. On the contrary, acid and peroxide values increased significantly, with changes in fatty acid component. There was a considerable correlation between appearance characteristics and changes in internal quality. The "sensory analysis-quality identification system" can provide a certain scientific basis for prediction of the content of chemical components in traditional Chinese medicine, preliminary judgment of quality of traditional Chinese medicine and real-time quality monitoring, which offers us novel ideas and reference for storage principles of traditional Chinese medicines of "pre-event prediction, during-event intervention and post-event identification". Copyright© by the Chinese Pharmaceutical Association.

Object-Oriented Analysis of Satellite Images Using Artificial Neural Networks for Post-Earthquake Buildings Change Detection

NASA Astrophysics Data System (ADS)

Khodaverdi zahraee, N.; Rastiveis, H.

2017-09-01

Earthquake is one of the most divesting natural events that threaten human life during history. After the earthquake, having information about the damaged area, the amount and type of damage can be a great help in the relief and reconstruction for disaster managers. It is very important that these measures should be taken immediately after the earthquake because any negligence could be more criminal losses. The purpose of this paper is to propose and implement an automatic approach for mapping destructed buildings after an earthquake using pre- and post-event high resolution satellite images. In the proposed method after preprocessing, segmentation of both images is performed using multi-resolution segmentation technique. Then, the segmentation results are intersected with ArcGIS to obtain equal image objects on both images. After that, appropriate textural features, which make a better difference between changed or unchanged areas, are calculated for all the image objects. Finally, subtracting the extracted textural features from pre- and post-event images, obtained values are applied as an input feature vector in an artificial neural network for classifying the area into two classes of changed and unchanged areas. The proposed method was evaluated using WorldView2 satellite images, acquired before and after the 2010 Haiti earthquake. The reported overall accuracy of 93% proved the ability of the proposed method for post-earthquake buildings change detection.

Anastrozole is cost-effective vs tamoxifen as initial adjuvant therapy in early breast cancer: Canadian perspectives on the ATAC completed-treatment analysis.

PubMed

Rocchi, A; Verma, S

2006-09-01

To conduct an economic analysis comparing tamoxifen and anastrozole (Arimidex) in the adjuvant treatment of hormone receptor-positive (HR+), post-menopausal early breast cancer patients. An economic model examined typical patients (64 years of age, HR+, 64% node negative) from the Arimidex, tamoxifen alone, or in combination (ATAC) trial over a lifetime horizon. Rates of events were derived from ATAC trial results. Post-trial event rates were drawn from the literature for tamoxifen; event rates for anastrozole were modified by the relative risks observed in the ATAC trial. Resource utilization was drawn from Statistics Canada's Population Health Model for breast cancer, supplemented by an expert panel. A public health care system perspective, 2004 Canadian prices and a 5% discount rate were employed. Anastrozole-taking patients incurred additional hormonal treatment costs compared to tamoxifen-taking patients (incremental lifetime cost, 6,974 Canadian dollars per patient), partially offset by reduced downstream recurrences of breast cancer (1,143 Canadian dollars lifetime savings per patient) for a net incremental cost of 5,796 Canadian dollars per patient on anastrozole. The anastrozole-treated patients were projected to experience a 5.6% absolute risk reduction of first breast cancer recurrence and a 2.8% absolute risk reduction in breast cancer death. This corresponded to 30,000 Canadian dollars per life year gained and 28,000 Canadian dollars per quality-adjusted life year gained (95% confidence interval, 17,428 to 54,605 Canadian dollars). The results were affected by the duration and extent of anastrozole benefit under sensitivity analysis but remained cost-effective. Compared to tamoxifen, anastrozole therapy is effective and cost-effective as initial adjuvant therapy in post-menopausal, HR+ early breast cancer patients.

Cost analysis of adjustments of the epidemiological surveillance system to mass gatherings.

PubMed

Zieliński, Andrzej

2011-01-01

The article deals with the problem of economical analysis of public health activities at mass gatherings. After presentation of elementary review of basic economical approaches to cost analysis author tries to analyze applicability of those methods to planning of mass gatherings. Difficulties in comparability of different events and lack of the outcome data at the stage of planning make most of the economic approaches unsuitable to application at the planning stage. Even applicability of cost minimization analysis may be limited to comparison of predicted costs of preconceived standards of epidemiological surveillance. Cost effectiveness performed ex post after the event when both costs and obtained effects are known, may bring more information for future selection of most effective procedures.

A meta-analysis of clinical and radiographic outcomes of posterior horn medial meniscus root repairs.

PubMed

Chung, Kyu Sung; Ha, Jeong Ku; Ra, Ho Jong; Kim, Jin Goo

2016-05-01

Although interest in medial meniscus posterior root tear (MMPRT) repair has increased, few case series have been reported. This meta-analysis aimed to examine the clinical and radiological effects of MMPRT repair by pooling pre- and post-operative data from case-series reports. A literature search was performed using MEDLINE/PubMed, the Cochrane Central Register of Controlled Trials, and EMBASE databases. Pre- and post-operative data were pooled to investigate the effects of MMPRT repair, including the Lysholm score improvement, meniscal extrusion (mm) reduction, progression of the Kellgren-Lawrence (K-L) grade, and cartilage status according to the Outerbridge classification. Treatment effects included paired standardized mean differences (difference in the pre- and post-operative mean outcomes divided by the standard deviation) for the Lysholm score and meniscal extrusion, as well as the pooled event rates of progression of K-L grade and cartilage status. As treatment effects, the Lysholm score increased by as much as 3.675 (P < 0.001), whereas meniscus extrusion was not reduced (n.s.). The overall pooled event rates of progression of K-L grade and cartilage status were 10.6 and 17.3 % (P < 0.001), respectively. According to the current literature, MMPRT repair resulted in significant improvements in the post-operative clinical subjective scores compared with the preoperative status. However, meniscus extrusion was not reduced. Considering the occurrence of progression of K-L grade and cartilage status, it did not prevent the progression of arthrosis completely. Based on these results, repair results in favourable outcomes for MMPRT. Meta-analysis, Level IV.

Clobazam-Treated Patients with Lennox Gastaut Syndrome Experienced Fewer Seizure-Related Injuries than Placebo Patients During Trail OV-1012

DTIC Science & Technology

2016-08-19

injuries based on Medical Dictionary for Regulatory Activities (MedDRA) preferred terms from all adverse event (AE) listings. Patients receiving...injuries For this post hoc analysis, medical review of all adverse event (AE) listings, based on Medical Dictionary for Regu- latory Activities (MedDRA...study results of clobazam in Lennox-Gastaut syndrome. Neurology 2011;77:1473–1481. 5. Medical Dictionary for Regulatory Activities. Available at: http

Minimising post-operative risk using a Post-Anaesthetic Care Tool (PACT): protocol for a prospective observational study and cost-effectiveness analysis

PubMed Central

Phillips, Nicole M; Kent, Bridie; Colgan, Stephen; Mohebbi, Mohammadreza

2015-01-01

Introduction While the risk of adverse events following surgery has been identified, the impact of nursing care on early detection of these events is not well established. A systematic review of the evidence and an expert consensus study in post-anaesthetic care identified essential criteria for nursing assessment of patient readiness for discharge from the post-anaesthetic care unit (PACU). These criteria were included in a new nursing assessment tool, the Post-Anaesthetic Care Tool (PACT), and incorporated into the post-anaesthetic documentation at a large health service. The aim of this study is to test the clinical reliability of the PACT and evaluate whether the use of PACT will (1) enhance the recognition and response to patients at risk of deterioration in PACU; (2) improve documentation for handover from PACU nurse to ward nurse; (3) result in improved patient outcomes and (4) reduce healthcare costs. Methods and analysis A prospective, non-randomised, pre-implementation and post-implementation design comparing: (1) patients (n=750) who have surgery prior to the implementation of the PACT and (2) patients (n=750) who have surgery after PACT. The study will examine the use of the tool through the observation of patient care and nursing handover. Patient outcomes and cost-effectiveness will be determined from health service data and medical record audit. Descriptive statistics will be used to describe the sample and compare the two patient groups (pre-intervention and post-intervention). Differences in patient outcomes between the two groups will be compared using the Cochran-Mantel-Haenszel test and regression analyses and reported as ORs with the corresponding 95% CIs. Conclusions This study will test the clinical reliability and cost-effectiveness of the PACT. It is hypothesised that the PACT will enable nurses to recognise and respond to patients at risk of deterioration, improve handover to ward nurses, improve patient outcomes, and reduce healthcare costs. PMID:26033942

Identifying causes of adverse events detected by an automated trigger tool through in-depth analysis.

PubMed

Muething, S E; Conway, P H; Kloppenborg, E; Lesko, A; Schoettker, P J; Seid, M; Kotagal, U

2010-10-01

To describe how in-depth analysis of adverse events can reveal underlying causes. Triggers for adverse events were developed using the hospital's computerised medical record (naloxone for opiate-related oversedation and administration of a glucose bolus while on insulin for insulin-related hypoglycaemia). Triggers were identified daily. Based on information from the medical record and interviews, a subject expert determined if an adverse drug event had occurred and then conducted a real-time analysis to identify event characteristics. Expert groups, consisting of frontline staff and specialist physicians, examined event characteristics and determined the apparent cause. 30 insulin-related hypoglycaemia events and 34 opiate-related oversedation events were identified by the triggers over 16 and 21 months, respectively. In the opinion of the experts, patients receiving continuous-infusion insulin and those receiving dextrose only via parenteral nutrition were at increased risk for insulin-related hypoglycaemia. Lack of standardisation in insulin-dosing decisions and variation regarding when and how much to adjust insulin doses in response to changing glucose levels were identified as common causes of the adverse events. Opiate-related oversedation events often occurred within 48 h of surgery. Variation in pain management in the operating room and post-anaesthesia care unit was identified by the experts as potential causes. Variations in practice, multiple services writing orders, multidrug regimens and variations in interpretation of patient assessments were also noted as potential contributing causes. Identification of adverse drug events through an automated trigger system, supplemented by in-depth analysis, can help identify targets for intervention and improvement.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moran, James J.; Kreuzer, Helen W.; Carman, April J.

Acid scavengers are frequently used as stabilizer compounds in a variety of applications. When used to stabilize volatile compounds such as nerve agents, the lower volatility and higher stability of acid scavengers make them more persistent in a post-event forensic setting. We are employing compound-specific stable isotope analysis of the carbon, nitrogen, and hydrogen components of three acid scavenging compounds (N,N-diethylaniline, tributylamine, and triethylamine) as a tool for distinguishing between different samples of the stabilizers. Combined analysis of three stable isotopes in these samples improves the technique’s resolving potential, enhancing sample matching capabilities. The compound specific methods developed here canmore » be applied to instances where these compounds are not pure, such as when mixed with an agent or when found as a residue at an event site. Effective sample matching can be crucial for linking compounds at multiple event sites or linking a supply inventory to an event.« less

When the Sky Falls NASA's Response to Bright Bolide Events Over Continental USA

NASA Technical Reports Server (NTRS)

Blaauw, R. C.; Cooke, W. J.; Kingery, A. M.; Moser, D. E.

2015-01-01

Being the only U.S. Government entity charged with monitoring the meteor environment, the Meteoroid Environment Office (MEO) has deployed a network of allsky and wide field meteor cameras, along with the appropriate software tools to quickly analyze data from these systems. However, the coverage of this network is still quite limited, forcing the incorporation of data from other cameras posted to the internet in analyzing many of the fireballs reported by the public and media. Information on these bright events often needs to be reported to NASA Headquarters by noon the following day; thus a procedure has been developed that determines the analysis process for a given fireball event based on the types and amount of data available. The differences between these analysis processes are shown by looking at four meteor events that the MEO responded to, all of which were large enough to produce meteorites.

Hydroacoustic monitoring of a salt cavity: an analysis of precursory events of the collapse

NASA Astrophysics Data System (ADS)

Lebert, F.; Bernardie, S.; Mainsant, G.

2011-09-01

One of the main features of "post mining" research relates to available methods for monitoring mine-degradation processes that could directly threaten surface infrastructures. In this respect, GISOS, a French scientific interest group, is investigating techniques for monitoring the eventual collapse of underground cavities. One of the methods under investigation was monitoring the stability of a salt cavity through recording microseismic-precursor signals that may indicate the onset of rock failure. The data were recorded in a salt mine in Lorraine (France) when monitoring the controlled collapse of 2 000 000 m3 of rocks surrounding a cavity at 130 m depth. The monitoring in the 30 Hz to 3 kHz frequency range highlights the occurrence of events with high energy during periods of macroscopic movement, once the layers had ruptured; they appear to be the consequence of the post-rupture rock movements related to the intense deformation of the cavity roof. Moreover the analysis shows the presence of some interesting precursory signals before the cavity collapsed. They occurred a few hours before the failure phases, when the rocks were being weakened and damaged. They originated from the damaging and breaking process, when micro-cracks appear and then coalesce. From these results we expect that deeper signal analysis and statistical analysis on the complete event time distribution (several millions of files) will allow us to finalize a complete typology of each signal families and their relations with the evolution steps of the cavity over the five years monitoring.

Underutilization of high-intensity statin therapy after hospitalization for coronary heart disease.

PubMed

Rosenson, Robert S; Kent, Shia T; Brown, Todd M; Farkouh, Michael E; Levitan, Emily B; Yun, Huifeng; Sharma, Pradeep; Safford, Monika M; Kilgore, Meredith; Muntner, Paul; Bittner, Vera

2015-01-27

National guidelines recommend use of high-intensity statins after hospitalization for coronary heart disease (CHD) events. This study sought to estimate the proportion of Medicare beneficiaries filling prescriptions for high-intensity statins after hospital discharge for a CHD event and to analyze whether statin intensity before hospitalization is associated with statin intensity after discharge. We conducted a retrospective cohort study using a 5% random sample of Medicare beneficiaries between 65 and 74 years old. Beneficiaries were included in the analysis if they filled a statin prescription after a CHD event (myocardial infarction or coronary revascularization) in 2007, 2008, or 2009. High-intensity statins included atorvastatin 40 to 80 mg, rosuvastatin 20 to 40 mg, and simvastatin 80 mg. Among 8,762 Medicare beneficiaries filling a statin prescription after a CHD event, 27% of first post-discharge fills were for a high-intensity statin. The percent filling a high-intensity statin post-discharge was 23.1%, 9.4%, and 80.7%, for beneficiaries not taking statins pre-hospitalization, taking low/moderate-intensity statins, and taking high-intensity statins before their CHD event, respectively. Compared with beneficiaries not on statin therapy pre-hospitalization, multivariable adjusted risk ratios for filling a high-intensity statin were 4.01 (3.58-4.49) and 0.45 (0.40-0.52) for participants taking high-intensity and low/moderate-intensity statins before their CHD event, respectively. Only 11.5% of beneficiaries whose first post-discharge statin fill was for a low/moderate-intensity statin filled a high-intensity statin within 365 days of discharge. The majority of Medicare beneficiaries do not fill high-intensity statins after hospitalization for CHD. Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Laboratory simulation of volcano seismicity.

PubMed

Benson, Philip M; Vinciguerra, Sergio; Meredith, Philip G; Young, R Paul

2008-10-10

The physical processes generating seismicity within volcanic edifices are highly complex and not fully understood. We report results from a laboratory experiment in which basalt from Mount Etna volcano (Italy) was deformed and fractured. The experiment was monitored with an array of transducers around the sample to permit full-waveform capture, location, and analysis of microseismic events. Rapid post-failure decompression of the water-filled pore volume and damage zone triggered many low-frequency events, analogous to volcanic long-period seismicity. The low frequencies were associated with pore fluid decompression and were located in the damage zone in the fractured sample; these events exhibited a weak component of shear (double-couple) slip, consistent with fluid-driven events occurring beneath active volcanoes.

Response of shoal grass, Halodule wrightii, to extreme winter conditions in the Lower Laguna Madre, Texas

USGS Publications Warehouse

Hicks, D.W.; Onuf, C.P.; Tunnell, J.W.

1998-01-01

Effects of a severe freeze on the shoal grass, Halodule wrightii, were documented through analysis of temporal and spatial trends in below-ground biomass. The coincidence of the second lowest temperature (-10.6??C) in 107 years of record, 56 consecutive hours below freezing, high winds and extremely low water levels exposed the Laguna Madre, TX, to the most severe cold stress in over a century. H. wrightii tolerated this extreme freeze event. Annual pre- and post-freeze surveys indicated that below-ground biomass estimated from volume was Unaffected by the freeze event. Nor was there any post-freeze change in biomass among intertidal sites directly exposed to freezing air temperatures relative to subtidal sites which remained submerged during the freezing period.

Influence of site and operator characteristics on carotid artery stent outcomes: analysis of the CAPTURE 2 (Carotid ACCULINK/ACCUNET Post Approval Trial to Uncover Rare Events) clinical study.

PubMed

Gray, William A; Rosenfield, Kenneth A; Jaff, Michael R; Chaturvedi, Seemant; Peng, Lei; Verta, Patrick

2011-02-01

The aim of this study was to analyze the CAPTURE 2 (Carotid ACCULINK/ACCUNET Post Approval Trial to Uncover Rare Events) study for physician- or site-related variables associated with differential outcomes for carotid artery stenting (CAS). The CAPTURE 2 trial is an ongoing, prospective, nonrandomized, independently adjudicated, multicenter clinical study enrolling high-surgical-risk patients undergoing CAS. In this assessment of the CAPTURE 2 study, the American Heart Association carotid endarterectomy guideline limits were used to define acceptable site and physician CAS outcomes; therefore, the resulting population of nonoctogenarian, asymptomatic subjects in this analysis is confined to 3,388 (of the total 5,297) subjects treated at 180 U.S. hospitals by 459 operators between March 2006 and January 2009. The rates of death, stroke, and myocardial infarction and death and stroke (DS) at 30 days were 3.5% and 3.3%, respectively, for the full CAPTURE 2 study cohort and 2.9% and 2.7%, respectively, for the asymptomatic, nonoctogenarian subgroup. In this subgroup, two-thirds of sites (118 of 180, 66%) had no DS events. Within the remaining sites, an inverse relationship between event rates and hospital patient volume as well as between event rates and individual operator volume was observed. The DS rates trended lower for interventional cardiologists compared with other specialties. Outcomes from the largest prospectively gathered, independently adjudicated, multicenter CAS study indicate that CAS can be safely performed in a variety of hospital settings by physicians with various specialties. The most important determinant of perioperative CAS outcomes was both site and operator CAS volume. A threshold of 72 cases was found to be necessary for consistently achieving a DS rate below 3% in this later-phase single arm study; background era and non-study operator experience will affect this determination. (Second Phase of "Carotid RX ACCULINK/RX ACCUNET Post-Approval Trial to Uncover Unanticipated or Rare Events"; NCT00302237). Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

The stressed eyewitness: the interaction of thematic arousal and post-event stress in memory for central and peripheral event information

PubMed Central

Echterhoff, Gerald; Wolf, Oliver T.

2012-01-01

Both arousal during the encoding of stimuli and subsequent stress can affect memory, often by increasing memory for important or central information. We explored whether event-based (thematic) arousal and post-event stress interact to selectively enhance eyewitnesses' memory for the central aspects of an observed incident. Specifically, we argue that memory for stimuli should be enhanced when (1) the stimuli are encoded under arousal (vs. non-arousal), and (2) stress is experienced soon after the encoding episode. We designed an experiment that extended previous research by manipulating arousal without changing the stimulus material, distinguishing between central and peripheral event information, and using a dynamic, life-like event instead of static pictures. After watching a video depicting a burglary under high or low thematic arousal, psychosocial stress was induced or not induced by the Trier Social Stress Test (TSST). Salivary cortisol was measured at standard intervals. Consistent with our prediction, we found a significant post-event stress × thematic arousal × centrality interaction, indicating that the recognition advantage for central event items over peripheral event items was most pronounced under both high thematic arousal and post-event stress. Because stress was induced after encoding this interaction cannot be explained by possible differences at encoding, such as narrowed attention. The centrality effect of post-event stress under high thematic arousal was statistically mediated by the cortisol increase, which suggests a key role of the stress hormone. We discuss implications of our findings for psychological and neuroscientific theories of emotional memory formation. PMID:22936900

The stressed eyewitness: the interaction of thematic arousal and post-event stress in memory for central and peripheral event information.

PubMed

Echterhoff, Gerald; Wolf, Oliver T

2012-01-01

Both arousal during the encoding of stimuli and subsequent stress can affect memory, often by increasing memory for important or central information. We explored whether event-based (thematic) arousal and post-event stress interact to selectively enhance eyewitnesses' memory for the central aspects of an observed incident. Specifically, we argue that memory for stimuli should be enhanced when (1) the stimuli are encoded under arousal (vs. non-arousal), and (2) stress is experienced soon after the encoding episode. We designed an experiment that extended previous research by manipulating arousal without changing the stimulus material, distinguishing between central and peripheral event information, and using a dynamic, life-like event instead of static pictures. After watching a video depicting a burglary under high or low thematic arousal, psychosocial stress was induced or not induced by the Trier Social Stress Test (TSST). Salivary cortisol was measured at standard intervals. Consistent with our prediction, we found a significant post-event stress × thematic arousal × centrality interaction, indicating that the recognition advantage for central event items over peripheral event items was most pronounced under both high thematic arousal and post-event stress. Because stress was induced after encoding this interaction cannot be explained by possible differences at encoding, such as narrowed attention. The centrality effect of post-event stress under high thematic arousal was statistically mediated by the cortisol increase, which suggests a key role of the stress hormone. We discuss implications of our findings for psychological and neuroscientific theories of emotional memory formation.

Mapping Live Fuel Moisture and the relation to drought and post fire events for Southern California region

NASA Astrophysics Data System (ADS)

Hatzopoulos, N.; Kim, S. H.; Kafatos, M.; Nghiem, S. V.; Myoung, B.

2016-12-01

Live Fuel Moisture is a dryness measure used by the fire departments to determine how dry is the current situation of the fuels from the forest areas. In order to map Live Fuel Moisture we conducted an analysis with a standardized regressional approach from various vegetation indices derived from remote sensing data of MODIS. After analyzing the results we concluded mapping Live Fuel Moisture using a standardized NDVI product. From the mapped remote sensed product we observed the appearance of extremely high dry fuels to be highly correlated with very dry years based on the overall yearly precipitation. The appearances of the extremely dry mapped fuels tend to have a direct association with fire events and observed to be a post fire indicator. In addition we studied the appearance of extreme dry fuels during critical months when season changes from spring to summer as well as the relation to fire events.

Analyzing the posting behaviors in news forums with incremental inter-event time

NASA Astrophysics Data System (ADS)

Sun, Zhi; Peng, Qinke; Lv, Jia; Zhong, Tao

2017-08-01

Online human behaviors are widely discussed in various fields. Three key factors, named priority, interest and memory are found crucial in human behaviors. Existing research mainly focuses on the identified and active users. However, the anonymous users and the inactive ones exist widely in news forums, whose behaviors do not receive enough attention. They cannot offer abundant postings like the others. It requires us to study posting behaviors of all the users including anonymous ones, identified ones, active ones and inactive ones in news forums only at the collective level. In this paper, the memory effects of the posting behaviors in news forums are investigated at the collective level. On the basis of the incremental inter-event time, a new model is proposed to describe the posting behaviors at the collective level. The results on twelve actual news events demonstrate the good performance of our model to describe the posting behaviors at the collective level in news forums. In addition, we find the symmetric incremental inter-event time distribution and the similar posting patterns in different durations.

Initial combination therapy with ambrisentan and tadalafil in connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH): subgroup analysis from the AMBITION trial

PubMed Central

Coghlan, John Gerry; Galiè, Nazzareno; Barberà, Joan Albert; Frost, Adaani E; Ghofrani, Hossein-Ardeschir; Hoeper, Marius M; Kuwana, Masataka; McLaughlin, Vallerie V; Peacock, Andrew J; Simonneau, Gérald; Vachiéry, Jean-Luc; Blair, Christiana; Gillies, Hunter; Miller, Karen L; Harris, Julia H N; Langley, Jonathan; Rubin, Lewis J

2017-01-01

Background Patients with connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH), in particular systemic sclerosis (SSc), had an attenuated response compared with idiopathic PAH in most trials. Thus, there is uncertainty regarding the benefit of PAH-targeted therapy in some forms of CTD-PAH. Objective To explore the safety and efficacy of initial combination therapy with ambrisentan and tadalafil versus ambrisentan or tadalafil monotherapy in patients with CTD-PAH and SSc-PAH enrolled in the AMBITION trial. Methods This was a post hoc analysis of patients with CTD-PAH and SSc-PAH from AMBITION, an event-driven, double-blind trial in patients with WHO functional class II/III PAH. Treatment-naive patients were randomised 2:1:1 to once-daily initial combination therapy with ambrisentan plus tadalafil or monotherapy with ambrisentan or tadalafil, respectively. The primary endpoint was time to the first clinical failure event (first occurrence of death, hospitalisation for worsening PAH, disease progression or unsatisfactory long-term clinical response). Results In the primary analysis set (N=500), 187 patients had CTD-PAH, of whom 118 had SSc-PAH. Initial combination therapy reduced the risk of clinical failure versus pooled monotherapy in each subgroup: CTD-PAH (HR 0.43 (95% CI 0.24 to 0.77)) and SSc-PAH (0.44 (0.22 to 0.89)). The most common AE was peripheral oedema, which was reported more frequently with initial combination therapy than monotherapy in the two PAH subgroups. The relative frequency of adverse events between those on combination therapy versus monotherapy was similar across subgroups. Conclusions This post hoc subgroup analysis provides evidence that CTD-PAH and SSc-PAH patients benefit from initial ambrisentan and tadalafil combination therapy. Trial registration number NCT01178073, post results. PMID:28039187

Initial combination therapy with ambrisentan and tadalafil in connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH): subgroup analysis from the AMBITION trial.

PubMed

Coghlan, John Gerry; Galiè, Nazzareno; Barberà, Joan Albert; Frost, Adaani E; Ghofrani, Hossein-Ardeschir; Hoeper, Marius M; Kuwana, Masataka; McLaughlin, Vallerie V; Peacock, Andrew J; Simonneau, Gérald; Vachiéry, Jean-Luc; Blair, Christiana; Gillies, Hunter; Miller, Karen L; Harris, Julia H N; Langley, Jonathan; Rubin, Lewis J

2017-07-01

Patients with connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH), in particular systemic sclerosis (SSc), had an attenuated response compared with idiopathic PAH in most trials. Thus, there is uncertainty regarding the benefit of PAH-targeted therapy in some forms of CTD-PAH. To explore the safety and efficacy of initial combination therapy with ambrisentan and tadalafil versus ambrisentan or tadalafil monotherapy in patients with CTD-PAH and SSc-PAH enrolled in the AMBITION trial. This was a post hoc analysis of patients with CTD-PAH and SSc-PAH from AMBITION, an event-driven, double-blind trial in patients with WHO functional class II/III PAH. Treatment-naive patients were randomised 2:1:1 to once-daily initial combination therapy with ambrisentan plus tadalafil or monotherapy with ambrisentan or tadalafil, respectively. The primary endpoint was time to the first clinical failure event (first occurrence of death, hospitalisation for worsening PAH, disease progression or unsatisfactory long-term clinical response). In the primary analysis set (N=500), 187 patients had CTD-PAH, of whom 118 had SSc-PAH. Initial combination therapy reduced the risk of clinical failure versus pooled monotherapy in each subgroup: CTD-PAH (HR 0.43 (95% CI 0.24 to 0.77)) and SSc-PAH (0.44 (0.22 to 0.89)). The most common AE was peripheral oedema, which was reported more frequently with initial combination therapy than monotherapy in the two PAH subgroups. The relative frequency of adverse events between those on combination therapy versus monotherapy was similar across subgroups. This post hoc subgroup analysis provides evidence that CTD-PAH and SSc-PAH patients benefit from initial ambrisentan and tadalafil combination therapy. NCT01178073, post results. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

The San Diego East County school shootings: a qualitative study of community-level post-traumatic stress.

PubMed

Palinkas, Lawrence A; Prussing, Erica; Reznik, Vivian M; Landsverk, John A

2004-01-01

Within one month (March 2001), two separate incidents of school shootings occurred at two different high schools within the same school district in San Diego's East County. To examine community-wide expressions of post-traumatic distress resulting from the shootings that may or may not fulfill DSM-IV criteria for post-traumatic stress disorder (PTSD), but which might interfere with treatment and the prevention of youth violence. A qualitative study was undertaken using Rapid Assessment Procedures (RAP) in four East San Diego County communities over a six-month period following the two events. Semi-structured interviews were conducted with 85 community residents identified through a maximum variation sampling technique. Interview transcripts were analyzed by coding consensus, co-occurrence, and comparison, using text analysis software. Three community-wide patterns of response to the two events were identified: (1) 52.9% of respondents reported intrusive reminders of the trauma associated with intense media coverage and subsequent rumors, hoaxes, and threats of additional acts of school violence; (2) 44.7% reported efforts to avoid thoughts, feelings, conversations, or places (i.e., schools) associated with the events; negative assessment of media coverage; and belief that such events in general cannot be prevented; and (3) 30.6% reported anger, hyper-vigilance, and other forms of increased arousal. Twenty-three (27.1%) respondents reported symptoms of fear, anxiety, depression, drug use, and psychosomatic symptoms in themselves or others. School shootings can precipitate symptoms of post-traumatic stress disorder at the community level. Such symptoms hinder the treatment of individuals with PTSD and the implementation of effective prevention strategies and programs.

The influence of historical events on psychoanalysis: a case history.

PubMed

Hinze, E

1986-01-01

Parts of the analysis of a patient are described, whose childhood had been overshadowed by serious traumatic experiences (death of father, flight). The interaction between these events which was dictated by recent history and the inner psychic world of the patient is investigated and consequences for the transference, countertransference and psychoanalytic technique are discussed. Special problems can arise when patient and analyst as members of the German post-war generation are equally confronted by the Nazi past during the analytical process.

Impact of Bone-targeted Therapies in Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer Patients Treated with Abiraterone Acetate: Post Hoc Analysis of Study COU-AA-302

PubMed Central

Saad, Fred; Shore, Neal; Van Poppel, Hendrik; Rathkopf, Dana E.; Smith, Matthew R.; de Bono, Johann S.; Logothetis, Christopher J.; de Souza, Paul; Fizazi, Karim; Mulders, Peter F.A.; Mainwaring, Paul; Hainsworth, John D.; Beer, Tomasz M.; North, Scott; Fradet, Yves; Griffin, Thomas A.; De Porre, Peter; Londhe, Anil; Kheoh, Thian; Small, Eric J.; Scher, Howard I.; Molina, Arturo; Ryan, Charles J.

2016-01-01

Background Metastatic castration-resistant prostate cancer (mCRPC) often involves bone, and bone-targeted therapy (BTT) has become part of the overall treatment strategy. Objective Investigation of outcomes for concomitant BTT in a post hoc analysis of the COU-AA-302 trial, which demonstrated an overall clinical benefit of abiraterone acetate (AA) plus prednisone over placebo plus prednisone in asymptomatic or mildly symptomatic chemotherapy-naïve mCRPC patients. Design, setting, and participants This report describes the third interim analysis (prespecified at 55% overall survival [OS] events) for the COU-AA-302 trial. Intervention Patients were grouped by concomitant BTT use or no BTT use. Outcome measurements and statistical analysis Radiographic progression-free survival and OS were coprimary end points. This report describes the third interim analysis (prespecified at 55% OS events) and involves patients treated with or without concomitant BTT during the COU-AA-302 study. Median follow-up for OS was 27.1 mo. Median time-to-event variables with 95% confidence intervals (CIs) were estimated using the Kaplan-Meier method. Adjusted hazard ratios (HRs), 95% CIs, and p values for concomitant BTT versus no BTT were obtained via Cox models. Results and limitations While the post hoc nature of the analysis is a limitation, superiority of AA and prednisone versus prednisone alone was demonstrated for clinical outcomes with or without BTT use. Compared with no BTT use, concomitant BTT significantly improved OS (HR 0.75; p = 0.01) and increased the time to ECOG deterioration (HR 0.75; p < 0.001) and time to opiate use for cancer-related pain (HR 0.80; p = 0.036). The safety profile of concomitant BTT with AA was similar to that reported for AA in the overall intent-to-treat population. Osteonecrosis of the jaw (all grade 1/2) with concomitant BTT use was reported in <3% of patients. Conclusions AA with concomitant BTT was safe and well tolerated in men with chemotherapy-naïve mCRPC. The benefits of AA on clinical outcomes were increased with concomitant BTT. Patient summary Treatment of advanced prostate cancer often includes bone-targeted therapy. This post hoc analysis showed that in patients with advanced prostate cancer who were treated with abiraterone acetate and prednisone in combination with bone-targeted therapy, there was a continued trend in prolongation of life when compared with patients treated with prednisone alone. Trial registration ClinicalTrials.gov NCT00887198. PMID:25985882

Post-partum depressive symptoms and medically assisted conception: a systematic review and meta-analysis.

PubMed

Gressier, F; Letranchant, A; Cazas, O; Sutter-Dallay, A L; Falissard, B; Hardy, P

2015-11-01

Does medically assisted conception increase the risk of post-partum depressive symptoms? Our literature review and meta-analysis showed no increased risk of post-partum depressive symptoms in women after medically assisted conception. Women who conceive with medically assisted conception, which can be considered as a stressful life event, could face an increased risk of depressive symptoms. However, no previous meta-analysis has been performed on the association between medically assisted conception and post-partum depressive symptoms. A systematic review with electronic searches of PubMed, ISI Web of Knowledge and PsycINFO databases up to December 2014 was conducted to identify articles evaluating post-partum depressive symptoms in women who had benefited from medically assisted conception compared with those with a spontaneous pregnancy. Meta-analyses were also performed on clinically significant post-partum depressive symptoms according to PRISMA guidelines. From 569 references, 492 were excluded on title, 42 on abstract and 17 others on full-text. Therefore, 18 studies were included in the review and 8 in the meta-analysis (2451 women) on clinically significant post-partum depressive symptoms after medically assisted conception compared with a spontaneous pregnancy. A sensitivity meta-analysis on assisted reproductive technologies and spontaneous pregnancy (6 studies, 1773 women) was also performed. The quality of the studies included in the meta-analyses was evaluated using the Strengthening the Reporting of Observational Studies in Epidemiology Statement for observational research. The data were pooled using RevMan software by the Cochrane Collaboration. Heterogeneity between studies was assessed from the results of the χ(2) and I(2) statistics. Biases were assessed with funnel plots and Egger's test. A fixed effects model was used for the meta-analyses because of the low level of heterogeneity between the studies. The systematic review of studies examining post-partum depressive symptoms after medically assisted conception compared with spontaneous pregnancy is not in favor of an association. Our meta-analysis on clinically significant post-partum depressive symptoms showed no significant difference between women who used medically assisted conception and those with spontaneous pregnancy: odds ratio (OR) = 0.93 (0.67-1.31), Z = 0.40, P = 0.69. The sensitivity meta-analysis reported no significant difference either: OR = 1.04 (0.71-1.52), Z = 0.18, P = 0.86. The literature on post-partum depressive symptoms and medically assisted conception is sparse. Only eight studies were available for our meta-analysis taking into account the rates of clinically significant post-partum depressive symptoms after medically assisted conception. However, the quality of the studies was high and the heterogeneity between trials was not significant. Whilst post-partum anxiety is more prevalent than depressive states and they can co-occur, it was not considered in these review and meta-analyses. In addition, other risk factors, such as maternal age, socio-demographic data or obstetric factors, are important for the assessment of post-partum depressive symptoms. Our review reported that several of these confounding risk factors were, however, analyzed and controlled for in the studies. Our literature review and meta-analyses showed no increased risk of post-partum depressive symptoms in women after medically assisted conception. Even if the rates of depressive symptoms are the same in the medically assisted conception population as among controls, the risk factors could be different. Though medically assisted conception can be considered as a stressful life event, these women have also lower prevalence of the usual risks. Professionals should also be careful to screen for prenatal and post-partum depressive symptoms, as with all pregnant women. Further studies are needed to clarify the specific features of post-partum depressive symptoms in this population. © The Author 2015. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

After the flood is before the next flood - post event review of the Central European Floods of June 2013. Insights, recommendations and next steps for future flood prevention

NASA Astrophysics Data System (ADS)

Szoenyi, Michael; Mechler, Reinhard; McCallum, Ian

2015-04-01

In early June 2013, severe flooding hit Central and Eastern Europe, causing extensive damage, in particular along the Danube and Elbe main watersheds. The situation was particularly severe in Eastern Germany, Austria, Hungary and the Czech Republic. Based on the Post Event Review Capability (PERC) approach, developed by Zurich Insurance's Flood Resilience Program to provide independent review of large flood events, we examine what has worked well (best practice) and opportunities for further improvement. The PERC overall aims to thoroughly examine aspects of flood resilience, flood risk management and catastrophe intervention in order to help build back better after events and learn for future events. As our research from post event analyses shows a lot of losses are in fact avoidable by taking the right measures pre-event and these measures are economically - efficient with a return of 4 Euro on losses saved for every Euro invested in prevention on average (Wharton/IIASA flood resilience alliance paper on cost benefit analysis, Mechler et al. 2014) and up to 10 Euros for certain countries. For the 2013 flood events we provide analysis on the following aspects and in general identify a number of factors that worked in terms of reducing the loss and risk burden. 1. Understanding risk factors of the Central European Floods 2013 We review the precursors leading up to the floods in June, with an extremely wet May 2013 and an atypical V-b weather pattern that brought immense precipitation in a very short period to the watersheds of Elbe, Donau and partially the Rhine in the D-A-CH countries and researched what happened during the flood and why. Key questions we asked revolve around which protection and risk reduction approaches worked well and which did not, and why. 2. Insights and recommendations from the post event review The PERC identified a number of risk factors, which need attention if risk is to be reduced over time. • Yet another "100-year flood" - risk perception and understanding of risk in the population. • Residual risk and the levee shadow effect - why the population "felt safe." • What is the overload case and how to implement it in flood protection systems? • Decision-making for the future under uncertainty - how to design to acceptable flood protection levels if we haven't seen yet what's physically possible. 3. How to protect - practical examples Finally, we outline practical examples for reducing the loss burden and risk over time. • "Flood protection hierarchy" - from location choice under a hazard perspective to mobile flood protection. • Risk-based approach and identification of critical infrastructure. • Integrated flood risk management in theory and practical application. • Role of insurance.

Flash floods and debris flow in the city area of Messina, North-East part of Sicily, Italy in October 2009: the case of the Giampilieri catchment

NASA Astrophysics Data System (ADS)

Aronica, G. T.; Brigandi, G.; Morey, N.

2010-09-01

Flash floods are phenomena in which the important hydrologic processes are occurring on the same spatial and temporal scales as the intense precipitation. Most of the catchment in the North-East part of Sicily (Italy) are small, with a steep slope, and characterized by short concentration times. These characteristics make those catchment prone to flash flood formation, as demonstrated by events that occurred in the area around Messina in the North-East part of Sicily, Italy in the last recent years. The events occurred on 25th October 2007 in the Mastroguglielmo torrent on the ionic sea coast, on 11th December 2008 in the Elicona catchment on the Tyrrhenian sea coast and on 1st October 2009 in Racinazzi and Giampilieri torrents on the ionic sea coast are an example of flash floods and debris flow events that caused not only significant economic damages to property, buildings, roads and bridges but also, for this that concern the 1st October 2009 flash flood event, loss of human life. This work is aimed by the 1st October 2009 flash flood and debris flow event where a devastating flooding was caused by a very intense rainfall concentrated over the Messina area. The storm caused severe flash floods in many villages around the city of Messina, such as Giampilieri, Scaletta Zanclea, Altolia Superiore and Molino with forty casualties and significant damage to property, buildings, roads and bridges estimated close to 200 million Euro. Main focus of this work is to perform a post event analysis of the 2009 flash flood event, putting together available meteorological and hydrological data in order to get better insight into temporal and spatial variability of the rain storm, the soil moisture condition and the consequent flash floods in the catchment of the Giampilieri catchment. Starting from these information another objective has been, then, to document the post-failure stage of event concerning slid materials. With the help of GIS technology and particularly spatial analysis, volume of debris gone down for the Giampilieri catchment has been calculated. The event was investigated using observed data from a raingauge network and hydraulic evidences. Statistical analysis using GEV distribution was performed and rainfall return period (storm severity) was estimated. Further, measured rainfall data and rainfall-runoff modeling were used to analyze the hydrological behaviour and to reconstruct flood and debris hydrographs. The study confirmed that post-flood investigation should focus on discharges and hydrological response of the catchment rather than simply analyzing statistical characteristics of rainfall. Thanks to LIDAR data produced immediately after the event, issued one meter precision DEM has been compared with a two meter precision one provided two years before. GIS maps with landslide and material deposit areas have been produced and analyzed.

Post-Event Processing in Children with Social Phobia

ERIC Educational Resources Information Center

Schmitz, Julian; Kramer, Martina; Blechert, Jens; Tuschen-Caffier, Brunna

2010-01-01

In the aftermath of a distressing social event, adults with social phobia (SP) engage in a review of this event with a focus on its negative aspects. To date, little is known about this post-event processing (PEP) and its relationship with perceived performance in SP children. We measured PEP in SP children (n = 24) and healthy controls (HC; n =…

29 CFR 4043.6 - Date of filing.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS General Provisions § 4043.6 Date of filing. (a) Post-Event notice... regular business day following the notice date, in the case of post-event notice. [61 FR 63989, Dec. 2...

29 CFR 4043.6 - Date of filing.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS General Provisions § 4043.6 Date of filing. (a) Post-Event notice... regular business day following the notice date, in the case of post-event notice. [61 FR 63989, Dec. 2...

29 CFR 4043.6 - Date of filing.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS General Provisions § 4043.6 Date of filing. (a) Post-Event notice... regular business day following the notice date, in the case of post-event notice. [61 FR 63989, Dec. 2...

29 CFR 4043.6 - Date of filing.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS General Provisions § 4043.6 Date of filing. (a) Post-Event notice... regular business day following the notice date, in the case of post-event notice. [61 FR 63989, Dec. 2...

29 CFR 4043.6 - Date of filing.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS General Provisions § 4043.6 Date of filing. (a) Post-Event notice... regular business day following the notice date, in the case of post-event notice. [61 FR 63989, Dec. 2...

Serious adverse events after HPV vaccination: a critical review of randomized trials and post-marketing case series.

PubMed

Martínez-Lavín, Manuel; Amezcua-Guerra, Luis

2017-10-01

This article critically reviews HPV vaccine serious adverse events described in pre-licensure randomized trials and in post-marketing case series. HPV vaccine randomized trials were identified in PubMed. Safety data were extracted. Post-marketing case series describing HPV immunization adverse events were reviewed. Most HPV vaccine randomized trials did not use inert placebo in the control group. Two of the largest randomized trials found significantly more severe adverse events in the tested HPV vaccine arm of the study. Compared to 2871 women receiving aluminum placebo, the group of 2881 women injected with the bivalent HPV vaccine had more deaths on follow-up (14 vs. 3, p = 0.012). Compared to 7078 girls injected with the 4-valent HPV vaccine, 7071 girls receiving the 9-valent dose had more serious systemic adverse events (3.3 vs. 2.6%, p = 0.01). For the 9-valent dose, our calculated number needed to seriously harm is 140 (95% CI, 79–653) [DOSAGE ERROR CORRECTED] . The number needed to vaccinate is 1757 (95% CI, 131 to infinity). Practically, none of the serious adverse events occurring in any arm of both studies were judged to be vaccine-related. Pre-clinical trials, post-marketing case series, and the global drug adverse reaction database (VigiBase) describe similar post-HPV immunization symptom clusters. Two of the largest randomized HPV vaccine trials unveiled more severe adverse events in the tested HPV vaccine arm of the study. Nine-valent HPV vaccine has a worrisome number needed to vaccinate/number needed to harm quotient. Pre-clinical trials and post-marketing case series describe similar post-HPV immunization symptoms.

Concurrent Bursty Behavior of Social Sensors in Sporting Events.

PubMed

Takeichi, Yuki; Sasahara, Kazutoshi; Suzuki, Reiji; Arita, Takaya

2015-01-01

The advent of social media expands our ability to transmit information and connect with others instantly, which enables us to behave as "social sensors." Here, we studied concurrent bursty behavior of Twitter users during major sporting events to determine their function as social sensors. We show that the degree of concurrent bursts in tweets (posts) and retweets (re-posts) works as a strong indicator of winning or losing a game. More specifically, our simple tweet analysis of Japanese professional baseball games in 2013 revealed that social sensors can immediately react to positive and negative events through bursts of tweets, but that positive events are more likely to induce a subsequent burst of retweets. We confirm that these findings also hold true for tweets related to Major League Baseball games in 2015. Furthermore, we demonstrate active interactions among social sensors by constructing retweet networks during a baseball game. The resulting networks commonly exhibited user clusters depending on the baseball team, with a scale-free connectedness that is indicative of a substantial difference in user popularity as an information source. While previous studies have mainly focused on bursts of tweets as a simple indicator of a real-world event, the temporal correlation between tweets and retweets implies unique aspects of social sensors, offering new insights into human behavior in a highly connected world.

A combination HIV reporter virus system for measuring post-entry event efficiency and viral outcome in primary CD4+ T cell subsets.

PubMed

Tilton, Carisa A; Tabler, Caroline O; Lucera, Mark B; Marek, Samantha L; Haqqani, Aiman A; Tilton, John C

2014-01-01

Fusion between the viral membrane of human immunodeficiency virus (HIV) and the host cell marks the end of the HIV entry process and the beginning of a series of post-entry events including uncoating, reverse transcription, integration, and viral gene expression. The efficiency of post-entry events can be modulated by cellular factors including viral restriction factors and can lead to several distinct outcomes: productive, latent, or abortive infection. Understanding host and viral proteins impacting post-entry event efficiency and viral outcome is critical for strategies to reduce HIV infectivity and to optimize transduction of HIV-based gene therapy vectors. Here, we report a combination reporter virus system measuring both membrane fusion and viral promoter-driven gene expression. This system enables precise determination of unstimulated primary CD4+ T cell subsets targeted by HIV, the efficiency of post-entry viral events, and viral outcome and is compatible with high-throughput screening and cell-sorting methods. Copyright © 2013 Elsevier B.V. All rights reserved.

Dual or Single Antiplatelet Therapy After Transcatheter Aortic Valve Implantation? A Systematic Review and Meta-Analysis.

PubMed

Vavuranakis, Manolis; Siasos, Gerasimos; Zografos, Theodoros; Oikonomou, Evangelos; Vrachatis, Dimitris; Kalogeras, Konstantinos; Papaioannou, Theodoros; Kolokathis, Michail-Aggelos; Moldovan, Carmen; Tousoulis, Dimitrios

2016-01-01

Transcatheter aortic valve implantation (TAVI) has undeniably earned a prestigious post in the quiver of interventional cardiologists against symptomatic severe aortic stenosis. Cerebrovascular events are listed within the most frequent complications. We performed a systematic search of EMBASE, MEDLINE, and the Cochrane library from inception to March 2016 for the following search terms (transcatheter AND antiplatelet) OR (transcatheter AND antithrombotic) to retrieve studies of dual antiplatelet treatment (DAPT) and single antiplatelet treatment (SAPT) in patients after TAVI to study thrombotic, hemorrhagic and cardiovascular events at 30 days post procedure. From a total of 208 records 4 studies met inclusion criteria. In the included studies, 286 patients were enrolled in the DAPT group and 354 patients in the SAPT group. There was no difference in all-cause mortality, cardiovascular mortality, stroke, and myocardial infraction 30 days post TAVI between DAPT and SAPT. However, patients in the DAPT group had a significantly increased incidence of lethal and major bleeding at 30 days of follow-up and the incidence of the combined end-point of stroke, spontaneous MI, all-cause mortality and major bleeding was significantly higher in the DAPT group in comparison to the SAPT group. DAPT compared to SAPT in patients after TAVI increases incidence of hemorrhagic events with no benefits in terms of thrombotic events and cardiovascular mortality. However, these data must be interpreted cautiously and the choice of DAPT over SAPT must be based on an individual patient characteristic according to medical practice criteria.

Trauma characteristics, post-traumatic symptoms, psychiatric disorders and suicidal behaviours: Results from the 2007 Australian National Survey of Mental Health and Wellbeing.

PubMed

Afzali, Mohammad H; Sunderland, Matthew; Batterham, Philip J; Carragher, Natacha; Slade, Tim

2017-11-01

The current study examined whether trauma characteristics such as the type and number of traumatic events were associated with three suicidal behaviours (i.e. ideation, plan and attempt) after adjusting for sociodemographic factors, post-traumatic symptoms and history of psychiatric disorders. Data came from the 2007 Australian National Survey of Mental Health and Wellbeing ( N = 8841). Respondents were asked about exposure to 28 traumatic events that occurred during their lifetime. Suicidal behaviours were measured using three statements about whether the person ever seriously thought about or planned or attempted suicide. Sexual violence and exposure to multiple traumatic events were particularly associated with suicidal behaviours. The presence of the emotional numbing symptom cluster and co-occurrence of three psychiatric disorders (major depressive disorder, alcohol use disorder and substance use disorder) also increased the odds of suicidal behaviours. Analysis of age of onset revealed that the mean age of traumatic exposure was earlier than the age at which suicidal behaviours emerged. The current study is the first to demonstrate that sexual violence and exposure to multiple traumatic events are associated with suicidal behaviours in a representative sample of Australian adults. The results underline the potential benefits of thorough assessment of trauma history, post-traumatic symptoms and history of psychiatric disorders and their additive contribution in suicide risk among trauma victims. These findings can be used by clinicians and researchers for early intervention programmes.

49 CFR 219.201 - Events for which testing is required.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) of this section, post-accident toxicological tests must be conducted after any event that involves... 49 Transportation 4 2010-10-01 2010-10-01 false Events for which testing is required. 219.201... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Post-Accident Toxicological Testing...

49 CFR 219.201 - Events for which testing is required.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) of this section, post-accident toxicological tests must be conducted after any event that involves... 49 Transportation 4 2014-10-01 2014-10-01 false Events for which testing is required. 219.201... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Post-Accident Toxicological Testing...

Forest Fire Management: A Comprehensive And Operational Approach

NASA Astrophysics Data System (ADS)

Fabrizi, Roberto; Perez, Bruno; Gomez, Antonio

2013-12-01

Remote sensing plays an important role in obtaining rapid and complete information on the occurrence and evolution in space and time of forest fires. In this paper, we present a comprehensive study of fire events through Earth Observation data for early warning, crisis monitoring and post-event damage assessment or a synthesis of the fire event, both in a wide spatial range (local to regional) and temporal scale (short to long term). The fire products are stored and distributed by means of a WebGIS and a Geoportal with additional auxiliary geospatial data. These products allow fire managers to perform analysis and decision making in a more comprehensive manner.

Bivalirudin or Unfractionated Heparin in Acute Coronary Syndromes.

PubMed

Valgimigli, Marco; Frigoli, Enrico; Leonardi, Sergio; Rothenbühler, Martina; Gagnor, Andrea; Calabrò, Paolo; Garducci, Stefano; Rubartelli, Paolo; Briguori, Carlo; Andò, Giuseppe; Repetto, Alessandra; Limbruno, Ugo; Garbo, Roberto; Sganzerla, Paolo; Russo, Filippo; Lupi, Alessandro; Cortese, Bernardo; Ausiello, Arturo; Ierna, Salvatore; Esposito, Giovanni; Presbitero, Patrizia; Santarelli, Andrea; Sardella, Gennaro; Varbella, Ferdinando; Tresoldi, Simone; de Cesare, Nicoletta; Rigattieri, Stefano; Zingarelli, Antonio; Tosi, Paolo; van 't Hof, Arnoud; Boccuzzi, Giacomo; Omerovic, Elmir; Sabaté, Manel; Heg, Dik; Jüni, Peter; Vranckx, Pascal

2015-09-10

Conflicting evidence exists on the efficacy and safety of bivalirudin administered as part of percutaneous coronary intervention (PCI) in patients with an acute coronary syndrome. We randomly assigned 7213 patients with an acute coronary syndrome for whom PCI was anticipated to receive either bivalirudin or unfractionated heparin. Patients in the bivalirudin group were subsequently randomly assigned to receive or not to receive a post-PCI bivalirudin infusion. Primary outcomes for the comparison between bivalirudin and heparin were the occurrence of major adverse cardiovascular events (a composite of death, myocardial infarction, or stroke) and net adverse clinical events (a composite of major bleeding or a major adverse cardiovascular event). The primary outcome for the comparison of a post-PCI bivalirudin infusion with no post-PCI infusion was a composite of urgent target-vessel revascularization, definite stent thrombosis, or net adverse clinical events. The rate of major adverse cardiovascular events was not significantly lower with bivalirudin than with heparin (10.3% and 10.9%, respectively; relative risk, 0.94; 95% confidence interval [CI], 0.81 to 1.09; P=0.44), nor was the rate of net adverse clinical events (11.2% and 12.4%, respectively; relative risk, 0.89; 95% CI, 0.78 to 1.03; P=0.12). Post-PCI bivalirudin infusion, as compared with no infusion, did not significantly decrease the rate of urgent target-vessel revascularization, definite stent thrombosis, or net adverse clinical events (11.0% and 11.9%, respectively; relative risk, 0.91; 95% CI, 0.74 to 1.11; P=0.34). In patients with an acute coronary syndrome, the rates of major adverse cardiovascular events and net adverse clinical events were not significantly lower with bivalirudin than with unfractionated heparin. The rate of the composite of urgent target-vessel revascularization, definite stent thrombosis, or net adverse clinical events was not significantly lower with a post-PCI bivalirudin infusion than with no post-PCI infusion. (Funded by the Medicines Company and Terumo Medical; MATRIX ClinicalTrials.gov number, NCT01433627.).

Tolerability and safety of the intravenous immunoglobulin octagam® 10% in patients with immune thrombocytopenia: a post-authorisation safety analysis of two non-interventional phase IV trials.

PubMed

Wietek, Stefan; Svorc, Daniel; Debes, Anette; Svae, Tor-Einar

2018-05-01

To provide detailed data on the tolerability and safety of octagam ® 10%, a ready-to-use intravenous immunoglobulin, in a subgroup of patients with immune thrombocytopenia (ITP) involved in an integrated analysis of post-authorisation safety surveillance (PASS) studies. A subgroup analysis was conducted using data collected from two non-interventional studies that included patients with ITP treated with octagam ® 10%. Patients were observed and monitored for possible adverse drug reactions (ADRs) during or after administration of octagam ® 10%, with a particular focus on thromboembolic events (TEEs). ADRs were analysed at the case and event level. In this analysis of 112 patients receiving octagam ® 10% (mean dose 0.4 g/kg/infusion), there were five cases with at least one adverse drug reaction (ADR) associated with 626 infusions of octagam ® 10% (case incidence of 0.8% per infusion). ADRs were of mild or moderate severity. There were a total of 10 events, most commonly back pain (n = 3) and headache (n = 2). Nausea, dizziness and a sensation of heaviness were also reported. The remaining two events involved drug exposure during pregnancy. There were no TEEs or other serious ADRs. In this subgroup analysis of patients who received octagam ® 10% (manufactured using an amended process) in two PASS studies, the overall ADR rate was low, with ADRs occurring in only 0.8% of all infusions. No TEEs or other serious ADRs were reported. Routine clinical use of octagam ® 10% was safe and well tolerated, with no unexpected safety issues, in patients with ITP. The two studies from which data were taken are registered with the International Standard Randomised Controlled Trial Number Registry, numbers ISRCTN58800347 and ISRCTN02245668.

INSAR observations of the DPRK event series

NASA Astrophysics Data System (ADS)

Mellors, R. J.; Ford, S. R.; Walter, W. R.

2017-12-01

Interferometric synthetic aperture radar (INSAR) data have revealed signals associated with the recent DPRK events in 2016 and 2017. These signals include decorrelation and indications of subsidence. Both standard phase differences and amplitude offsets are calculated. We show results of INSAR analysis as conducted using C and L band data and investigate the causes of the decorrelation (e.g. subsidence, landslide, or spall) and compare the observed signal with numerical models of deformation and seismic observations. A time series approach is applied to constrain post-event deformation at the weeks to months' timescale. We compare the INSAR observations of the DPRK tests with previous observations of events at other source regions using ERS archive data, which revealed a variety of post-seismic signatures. The signatures are evaluated with respect to the known geology and causes, including long-term surface relaxation and possible groundwater/thermal effects. Particular focus is on the sites on Pahute and Rainier Mesa, which displayed long-term subsidence signals that extended for several years after the explosions. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. Lawrence Livermore National Security, LLC

Hyaluronic acid for post sinus surgery care: systematic review and meta-analysis.

PubMed

Fong, E; Garcia, M; Woods, C M; Ooi, E

2017-01-01

Wound healing after endoscopic sinus surgery may result in adhesion formation. Hyaluronic acid may prevent synechiae development. A systematic review was performed to evaluate the current evidence on the clinical efficacy of hyaluronic acid applied to the nasal cavity after sinus surgery. Studies using hyaluronic acid as an adjunct treatment following endoscopic sinus surgery for chronic rhinosinusitis were identified. The primary outcome was adhesion formation rates. A meta-analysis was performed on adhesion event frequency. Secondary outcome measures included other endoscopic findings and patient-reported outcomes. Thirteen studies (501 patients) met the selection criteria. A meta-analysis of adhesion formation frequency on endoscopy demonstrated a lower risk ratio in the hyaluronic acid intervention group (42 out of 283 cases) compared to the control group (81 out of 282) of 0.52 (95 per cent confidence interval = 0.37-0.72). Hyaluronic acid use was not associated with any significant adverse events. Hyaluronic acid appears to be clinically safe and well tolerated, and may be useful in the early stages after sinus surgery to limit adhesion rate. Further research, including larger randomised controlled trials, is required to evaluate patient- and clinician-reported outcomes of hyaluronic acid post sinus surgery.

Can Disproportionality Analysis of Post-marketing Case Reports be Used for Comparison of Drug Safety Profiles?

PubMed

Michel, Christiane; Scosyrev, Emil; Petrin, Michael; Schmouder, Robert

2017-05-01

Clinical trials usually do not have the power to detect rare adverse drug reactions. Spontaneous adverse reaction reports as for example available in post-marketing safety databases such as the FDA Adverse Event Reporting System (FAERS) are therefore a valuable source of information to detect new safety signals early. To screen such large data-volumes for safety signals, data-mining algorithms based on the concept of disproportionality have been developed. Because disproportionality analysis is based on spontaneous reports submitted for a large number of drugs and adverse event types, one might consider using these data to compare safety profiles across drugs. In fact, recent publications have promoted this practice, claiming to provide guidance on treatment decisions to healthcare decision makers. In this article we investigate the validity of this approach. We argue that disproportionality cannot be used for comparative drug safety analysis beyond basic hypothesis generation because measures of disproportionality are: (1) missing the incidence denominators, (2) subject to severe reporting bias, and (3) not adjusted for confounding. Hypotheses generated by disproportionality analyses must be investigated by more robust methods before they can be allowed to influence clinical decisions.

Egg, red meat, and poultry intake and risk of lethal prostate cancer in the prostate specific antigen-era: incidence and survival

PubMed Central

Richman, Erin L.; Kenfield, Stacey A.; Stampfer, Meir J.; Giovannucci, Edward L.; Chan, June M.

2011-01-01

Red and processed meat may increase risk of advanced prostate cancer. Data on post-diagnostic diet and prostate cancer are sparse, but post-diagnostic intake of poultry with skin and eggs may increase risk of disease progression. Therefore, we prospectively examined total, unprocessed, and processed red meat, poultry, and eggs in relation to risk of lethal prostate cancer (e.g. men without cancer at baseline who developed distant organ metastases or died from prostate cancer during follow-up) among 27, 607 men followed from 1994–2008. We also performed a case-only survival analysis to examine post-diagnostic consumption of these foods and risk of lethal prostate cancer among the 3,127 men initially diagnosed with non-metastatic prostate cancer during follow-up. In the incidence analysis, we observed 199 events during 306,715 person-years. Men who consumed 2.5 or more eggs per week had an 81% increased risk of lethal prostate cancer compared to men who consumed less than 0.5 eggs per week (HR: 1.81; 95% confidence interval (CI): 1.13, 2.89; p-trend: 0.01). In the case-only survival analysis, we observed 123 events during 19,354 person-years. There were suggestive, but not statistically significant, positive associations between post-diagnostic poultry (HR ≥3.5 vs. <1.5 servings per week: 1.69; 95%CI: 0.96, 2.99; p-trend: 0.07) and post-diagnostic processed red meat (HR ≥3 vs. <0.5 servings per week: 1.45; 95%CI: 0.73, 2.87; p-trend: 0.08) and risk of progression of localized prostate cancer to lethal disease. In conclusion, consumption of eggs may increase risk of developing a lethal-form of prostate cancer among healthy men. PMID:21930800

Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets.

PubMed

Maciejewski, Mateusz; Lounkine, Eugen; Whitebread, Steven; Farmer, Pierre; DuMouchel, William; Shoichet, Brian K; Urban, Laszlo

2017-08-08

The Food and Drug Administration Adverse Event Reporting System (FAERS) remains the primary source for post-marketing pharmacovigilance. The system is largely un-curated, unstandardized, and lacks a method for linking drugs to the chemical structures of their active ingredients, increasing noise and artefactual trends. To address these problems, we mapped drugs to their ingredients and used natural language processing to classify and correlate drug events. Our analysis exposed key idiosyncrasies in FAERS, for example reports of thalidomide causing a deadly ADR when used against myeloma, a likely result of the disease itself; multiplications of the same report, unjustifiably increasing its importance; correlation of reported ADRs with public events, regulatory announcements, and with publications. Comparing the pharmacological, pharmacokinetic, and clinical ADR profiles of methylphenidate, aripiprazole, and risperidone, and of kinase drugs targeting the VEGF receptor, demonstrates how underlying molecular mechanisms can emerge from ADR co-analysis. The precautions and methods we describe may enable investigators to avoid confounding chemistry-based associations and reporting biases in FAERS, and illustrate how comparative analysis of ADRs can reveal underlying mechanisms.

Numerical 3D flow simulation of attached cavitation structures at ultrasonic horn tips and statistical evaluation of flow aggressiveness via load collectives

NASA Astrophysics Data System (ADS)

Mottyll, S.; Skoda, R.

2015-12-01

A compressible inviscid flow solver with barotropic cavitation model is applied to two different ultrasonic horn set-ups and compared to hydrophone, shadowgraphy as well as erosion test data. The statistical analysis of single collapse events in wall-adjacent flow regions allows the determination of the flow aggressiveness via load collectives (cumulative event rate vs collapse pressure), which show an exponential decrease in agreement to studies on hydrodynamic cavitation [1]. A post-processing projection of event rate and collapse pressure on a reference grid reduces the grid dependency significantly. In order to evaluate the erosion-sensitive areas a statistical analysis of transient wall loads is utilised. Predicted erosion sensitive areas as well as temporal pressure and vapour volume evolution are in good agreement to the experimental data.

Switching between phenytoin generics in patients with epilepsy may lead to increased risk of breakthrough seizure: chart analysis and practice recommendations.

PubMed

Shin, Jung-Won; Chu, Kon; Jung, Keun-Hwa; Lee, Soon-Tae; Moon, Jangsup; Lee, Sang Kun

2014-12-01

The Food and Drug Administration (FDA) only requires bioequivalence testing of generic substitutions in order for them to be deemed equivalen to the original product. There may be a large difference of bioavailability among the generic drugs that especially have a narrow therapeutic index, and this may affect clinical outcomes. We aimed to determine whether switching from generic-to-generic equivalent anti-epileptic drugs (AEDs) in patients with epilepsy is associated with clinical outcomes. We performed a retrospective study using the electronic medical records of a tertiary hospital. Adults with a history of epilepsy who used a generic phenytoin and whose therapy was switched to another generic phenytoin between January 2012 and June 2013 were included (n = 80). We compared the drug concentration of phenytoin and seizure events before and after the switch. After switching their generic phenytoin, 33 out of 80 patients (41%) suffered from increasing seizure events (pre-interchange period, 0.44 ± 0.97; post-interchange period, 1.24 ± 2.05; p < 0.0001). The number of medical visits for acute seizure significantly increased in the post-interchange period. The phenytoin serum concentration of all the patients was lesser in the post-interchange period than in the pre-interchange period. (pre-interchange period, 12.79 μg/mL; post-interchange period, 6.36 μg/mL; p < 0.0001). Among the patients with drug resistant epilepsy (DRE), 17 patients (84.2%) had increasing seizure events in the post-interchange period. We confirmed that there was a significant difference in bioavailability between generic phenytoin. Therefore, when using or switching generic anti-epileptic drugs, therapeutic drug monitoring must be done, and the patients' condition must be considered.

Post- and peritraumatic stress in disaster survivors: an explorative study about the influence of individual and event characteristics across different types of disasters.

PubMed

Grimm, Anna; Hulse, Lynn; Preiss, Marek; Schmidt, Silke

2012-01-01

Examination of existing research on posttraumatic adjustment after disasters suggests that survivors' posttraumatic stress levels might be better understood by investigating the influence of the characteristics of the event experienced on how people thought and felt, during the event as well as afterwards. To compare survivors' perceived post- and peritraumatic emotional and cognitive reactions across different types of disasters. Additionally, to investigate individual and event characteristics. In a European multi-centre study, 102 survivors of different disasters terror attack, flood, fire and collapse of a building were interviewed about their responses during the event. Survivors' perceived posttraumatic stress levels were assessed with the Impact of Event Scale-Revised (IES-R). Peritraumatic emotional stress and risk perception were rated retrospectively. Influences of individual characteristics, such as socio-demographic data, and event characteristics, such as time and exposure factors, on post- and peritraumatic outcomes were analyzed. Levels of reported post- and peritraumatic outcomes differed significantly between types of disasters. Type of disaster was a significant predictor of all three outcome variables but the factors gender, education, time since event, injuries and fatalities were only significant for certain outcomes. Results support the hypothesis that there are differences in perceived post- and peritraumatic emotional and cognitive reactions after experiencing different types of disasters. However, it should be noted that these findings were not only explained by the type of disaster itself but also by individual and event characteristics. As the study followed an explorative approach, further research paths are discussed to better understand the relationships between variables.

Local infiltration analgesia: a 2-year follow-up of patients undergoing total hip arthroplasty.

PubMed

Kuchálik, Ján; Magnuson, Anders; Lundin, Anders; Gupta, Anil

2017-12-01

Local infiltration analgesia (LIA) is commonly used for postoperative pain management following total hip arthroplasty (THA). However, the long-term effects of the component drugs are unclear. The aim of our study was to investigate functional outcome, quality of life, chronic post-surgical pain, and adverse events in patients within 2 years of undergoing THA. The study was a secondary analysis of data from a previous larger study. Eighty patients were randomized to receive either intrathecal morphine (Group ITM) or local infiltration analgesia (Group LIA) for pain management in a double-blind study. The parameters measured were patient-assessed functional outcome [using the Hip dysfunction and Osteo-arthritis Outcome Score (HOOS) questionnaire], health-related quality of life [using the European Quality of Life-5 dimensions (EQ-5D) questionnaire and the 36-Item Short Form Health Survey (SF-36) score], and pain using the numeric rating score (NRS), with persistent post-surgical pain having a NRS of > 3 or a HOOS pain sub-score of > 30. All complications and adverse events were investigated during the first 2 years after primary surgery. Pain intensity and rescue analgesic consumption were similar between the groups after hospital discharge. No differences were found in HOOS or SF-36 score between the groups up to 6 months after surgery. A significant group × time interaction was seen in the EQ 5D form in favor of the LIA group. No between-group difference in persistent post-surgical pain was found at 3 or 6 months, or in adverse events up to 2 years after surgery. Analysis of functional outcome, quality of life, and post-discharge surgical pain did not reveal significant differences between patients receiving LIA and those receiving ITM. LIA was found to be a safe technique for THA during the long-term follow-up. However, it should be noted that these conclusions are based on a limited number of patients.

Regional analysis of distribution of pre and post 2015 Nepal Earthquake landslides

NASA Astrophysics Data System (ADS)

Valagussa, Andrea; Frattini, Paolo; Crosta, Giovanni; Valbuzzi, Elena

2016-04-01

A magnitude 7.8 earthquake struck Nepal on April 25, 2015. Three landslide inventories have been prepared in four districts: Dhading (1885 km2), Sindhupalchok (2488 km2), Rasuwa (1522 km2) and Nuwakot (1194 km2), that are located north of Kathmandu. These inventories extend 14 to 138 km SE from the epicenter of the main shock (April 25, 2015), 4.5 to 143 km NW from the epicenter of the main aftershock (May 12, 2015), and 34 to 136 km from the Main Frontal Thrust. The first inventory is a coseismic and post-seismic landslide inventory based on multi-temporal images (Google Earth, Google Crisis maps, Bing maps), and helicopter-based video. The second one is a pre-event shallow landslide inventory. In these two inventories the most abundant landslide types are: debris flows, shallow translational slides, and rockfalls. The third is a deep seated landslide inventory, in which the most represented landslide types are rock avalanches, slumps, rockslides and deep-seated gravitational slope deformations (DSGSD). All the landslides have been mapped as individual polygons. For the analysis we focus our attention on four districts: First we studied how the landslide frequency density changes as a function of topographic parameters (i.e. slope gradient, slope aspect, and elevation). The analyses have been based on the ASTER Global Digital Elevation Model (ASTER GDEM). For coseismic and post-seismic landslides we observed that the mean slope gradient at which the landslide occurs is higher with respect to the two other inventories (50° and 30/40° respectively). The slope aspect of coseismic and post-seismic landslides is also different, with a larger frequency of landslides towards SW, whereas in pre-event landslides the most common slope aspect is SE. This could be related to the direction of the seismic wave. At least the coseismic and post-seismic landslides occur, in mean, at an elevation lower than the pre-event landslides. We also analyzed the relationship between the landslide frequency density and the lithology in which each landslide occurs to better understand if a particular geological suite is more prone to give landslides, both in seismic and non-seismic conditions. The landslide density for the Deep Seated Landslides and the Pre-Event Shallow landslides does not shows particular changes with the lithology in which the landslide occurred. The Deep Seated Landslides seem to be more abundant in marbles with respect the others lithologies. The pre-event landslides seem to be more abundant in gneiss and shale. Different observations could be done for the coseismic and post-seismic landslides, which show a high value of density (5.13 landslides per km2) for schist, limestone and quartzite. Instead, the granites have a lower number of landslides, as observed for the two other inventories.

Patterns of emergency room visits, admissions and death following recommended pediatric vaccinations - a population based study of 969,519 vaccination events.

PubMed

Wilson, Kumanan; Hawken, Steven; Potter, Beth K; Chakraborty, Pranesh; Kwong, Jeff; Crowcroft, Natasha; Rothwell, Deanna; Manuel, Doug

2011-05-12

The risk of immediate adverse events due to the inflammation created by a vaccine is a potential concern for pediatric vaccine programs. We analyzed data on children born between March 2006 and March 2009 in the province of Ontario. Using the self-controlled case series design, we examined the risk of the combined endpoint of emergency room visit and hospital admission in the immediate 3 days post vaccination to a control period 9-18 days after vaccination. We examined the end points of emergency room visits, hospital admissions and death separately as secondary outcomes. We examined 969,519 separate vaccination events. The relative incidence of our combined end point was 0.85 (0.80-0.90) for vaccination at age 2 months, 0.74 (0.69-0.79) at age 4 months and 0.68 (0.63-0.72) at age 6 months. The relative incidence was reduced for the individual endpoints of emergency room visits, admissions and death. There were 5 or fewer deaths in the risk interval of all 969,519 vaccination events. In a post hoc analysis we observed a large reduction in events in the immediate 3 days prior to vaccination suggesting a large healthy vaccinee effect. There was no increased incidence of the combined end point of emergency room visits and hospitalizations in the 3-day period immediately following vaccination, nor for individual endpoints or death. The health vaccinee effect could create the perception of worsening health following vaccines in the absence of any vaccine adverse effect and could also mask an effect in the immediate post-vaccination period. Copyright © 2011 Elsevier Ltd. All rights reserved.

Safety of inhaled glycopyrronium in patients with COPD: a comprehensive analysis of clinical studies and post-marketing data.

PubMed

D'Urzo, Anthony D; Kerwin, Edward M; Chapman, Kenneth R; Decramer, Marc; DiGiovanni, Robert; D'Andrea, Peter; Hu, Huilin; Goyal, Pankaj; Altman, Pablo

2015-01-01

Chronic use of inhaled anticholinergics by patients with chronic obstructive pulmonary disease (COPD) has raised long-term safety concerns, particularly cardiovascular. Glycopyrronium is a once-daily anticholinergic with greater receptor selectivity than previously available agents. We assessed the safety of inhaled glycopyrronium using data pooled from two analysis sets, involving six clinical studies and over 4,000 patients with COPD who received one of the following treatments: glycopyrronium 50 μg, placebo (both delivered via the Breezhaler device), or tiotropium 18 μg (delivered via the HandiHaler device). Data were pooled from studies that varied in their duration and severity of COPD of the patients (ie, ≤12 weeks duration with patients having moderate or severe COPD; and >1 year duration with patients having severe and very severe COPD). Safety comparisons were made for glycopyrronium vs tiotropium or placebo. Poisson regression was used to assess the relative risk for either active drug or placebo (and between drugs where placebo was not available) for assessing the incidence of safety events. During post-marketing surveillance (PMS), safety was assessed by obtaining reports from various sources, and disproportionality scores were computed using EMPIRICA. In particular, the cardiac safety of glycopyrronium during the post-marketing phase was evaluated. The overall incidence of adverse events and deaths was similar across groups, while the incidence of serious adverse events was numerically higher in placebo. Furthermore, glycopyrronium did not result in an increased risk of cerebro-cardiovascular events vs placebo. There were no new safety reports during the PMS phase that suggested an increased risk compared to results from the clinical studies. Moreover, the cardiac safety of glycopyrronium during the PMS phase was also consistent with the clinical data. The overall safety profile of glycopyrronium was similar to its comparators indicating no increase in the overall risk for any of the investigated safety end points.

Early Child Disaster Mental Health Interventions: A Review of the Empirical Evidence

ERIC Educational Resources Information Center

Pfefferbaum, Betty; Nitiéma, Pascal; Tucker, Phebe; Newman, Elana

2017-01-01

Background: The need to establish an evidence base for early child disaster interventions has been long recognized. Objective: This paper presents a descriptive analysis of the empirical research on early disaster mental health interventions delivered to children within the first 3 months post event. Methods: Characteristics and findings of the…

Completing the Three Stages of Doctoral Education: An Event History Analysis

ERIC Educational Resources Information Center

Ampaw, Frim D.; Jaeger, Audrey J.

2012-01-01

Doctoral programs have high dropout rates of 43% representing the highest among all post-baccalaureate programs. Cross sectional studies of doctoral students' retention have showed the importance of financial aid in predicting degree completion. These studies however, do not estimate the labor market's effect on doctoral student retention and…

Social Media Listening for Routine Post-Marketing Safety Surveillance.

PubMed

Powell, Gregory E; Seifert, Harry A; Reblin, Tjark; Burstein, Phil J; Blowers, James; Menius, J Alan; Painter, Jeffery L; Thomas, Michele; Pierce, Carrie E; Rodriguez, Harold W; Brownstein, John S; Freifeld, Clark C; Bell, Heidi G; Dasgupta, Nabarun

2016-05-01

Post-marketing safety surveillance primarily relies on data from spontaneous adverse event reports, medical literature, and observational databases. Limitations of these data sources include potential under-reporting, lack of geographic diversity, and time lag between event occurrence and discovery. There is growing interest in exploring the use of social media ('social listening') to supplement established approaches for pharmacovigilance. Although social listening is commonly used for commercial purposes, there are only anecdotal reports of its use in pharmacovigilance. Health information posted online by patients is often publicly available, representing an untapped source of post-marketing safety data that could supplement data from existing sources. The objective of this paper is to describe one methodology that could help unlock the potential of social media for safety surveillance. A third-party vendor acquired 24 months of publicly available Facebook and Twitter data, then processed the data by standardizing drug names and vernacular symptoms, removing duplicates and noise, masking personally identifiable information, and adding supplemental data to facilitate the review process. The resulting dataset was analyzed for safety and benefit information. In Twitter, a total of 6,441,679 Medical Dictionary for Regulatory Activities (MedDRA(®)) Preferred Terms (PTs) representing 702 individual PTs were discussed in the same post as a drug compared with 15,650,108 total PTs representing 946 individual PTs in Facebook. Further analysis revealed that 26 % of posts also contained benefit information. Social media listening is an important tool to augment post-marketing safety surveillance. Much work remains to determine best practices for using this rapidly evolving data source.

Two decades of pharmacovigilance and clinical experience with highly purified rabies immunoglobulin F(ab')2 fragments.

PubMed

Reveneau, Elisa; Cottin, Pascale; Rasuli, Anvar

2017-03-01

Rabies is a worldwide zoonotic viral disease with no specific treatment once symptoms occur; manifest disease is almost always fatal. WHO recommendations for exposed individuals include immediate attention to the wound and use of rabies immunoglobulin and/or vaccine for post-exposure prophylaxis (PEP). Here, we provide an overview of the clinical experience with a highly purified preparation of F(ab') 2 fragments from equine rabies immunoglobulin (F(ab') 2 pERIG; Favirab TM ) in rabies PEP. Areas covered: Our review comprises a retrospective analysis of adverse event reports in the Sanofi Pasteur global pharmacovigilance database for F(ab') 2 pERIG, including adverse event reports from eight Sanofi Pasteur-sponsored clinical trials and post-market surveillance data collected between 1995 and 2014. The general safety profile of F(ab') 2 pERIG is discussed, as are the occurrence of rare anaphylactic reactions, and suspected intervention failure. Expert commentary: Over 20 years of clinical development and post-licensure experience has established the safety and effectiveness of F(ab') 2 pERIG (Favirab TM ) in rabies PEP.

Decreasing IV Infiltrates in the Pediatric Patient--System-Based Improvement Project.

PubMed

Major, Tracie Wilt; Huey, Tricia K

2016-01-01

Intravenous infiltrates pose tremendous risk for the hospitalized pediatric patient. Infiltrate events increase hospital-acquired harm, the number of painful procedures, use of supplies, length of stay, and nursing time; it threatens relationships essential in patient- and family-centered care. The goal of this quality improvement project was to achieve a 10% decrease in the baseline infiltrate rate on two inpatient units and in the overall infiltrate rate across all of the pediatric units. A Lean Six Sigma methodology was used to guide project activities. Improvement strategies focused on evidence-based education, intravenous (IV) catheter securement, and family engagement. A comparative purposive sample was used to evaluate the pre- and post-implementation period to determine if desired project success measures were achieved. Data analysis revealed positive results across all units, with the number of events (n = 51 pre; n = 19 post) and the infiltration rates (13.5 pre; 7.1 post) decreasing over a three-month period. A decrease was also noted in the overall percent of IVs that infiltrated in the first 24 hours (45% pre; 42% post). A statistically significant increase (t = 15.16; p < 0.001) was noted in nurses' education pre- and post-assessment survey scores. The family engagement strategy revealed overall parental responses to be 88% positive. By decreasing infiltrates, quality of care improved, resulting in the delivery of safe, effective, and patient-centered IV therapy.

Cost-effectiveness analysis of valsartan versus losartan and the effect of switching.

PubMed

Baker, Timothy M; Goh, Jowern; Johnston, Atholl; Falvey, Heather; Brede, Yvonne; Brown, Ruth E

2012-01-01

Losartan will shortly become generic, and this may encourage switching to the generic drug. However, valsartan was shown in a meta-analysis to be statistically superior in lowering blood pressure (BP) to losartan. This paper examines the costs of treatment with these two drugs and the potential consequences of switching established valsartan patients to generic losartan. A US payer cost-effectiveness model was developed incorporating the risk of cardiovascular disease (CVD) events related to systolic blood pressure (SBP) control comparing valsartan to continual losartan and switching from valsartan to generic losartan. The model, based upon a meta-analysis by Nixon et al. and Framingham equations, included first CVD event costs calculated from US administrative data sets and utility values from published sources. The modeled outcomes were number of CVD events, costs and incremental cost per quality-adjusted life-year (QALY) and life-year (LY). Fewer patients had fatal and non-fatal CVD events with valsartan therapy compared with continual losartan and with patients switched from valsartan to generic losartan. The base-case model results indicated that continued treatment with valsartan had an incremental cost-effectiveness ratio of $27,268 and $25,460 per life year gained, and $32,313 and $30,170 per QALY gained, relative to continual losartan and switching treatments, respectively. Sensitivity analyses found that patient discontinuation post-switching was a sensitive parameter. Including efficacy offsets with lowered adherence or discontinuation resulted in more favorable ratios for valsartan compared to switching therapy. The model does not evaluate post-primary CVD events and considers change in SBP from baseline level as the sole predictor of CVD risk. Valsartan appears to be cost-effective compared to switching to generic losartan and switching to the generic drug does not support a cost offset argument over the longer term. Physicians should continue to consider the needs of individual patient and not cost offsets.

Timing and completeness of trial results posted at ClinicalTrials.gov and published in journals.

PubMed

Riveros, Carolina; Dechartres, Agnes; Perrodeau, Elodie; Haneef, Romana; Boutron, Isabelle; Ravaud, Philippe

2013-12-01

The US Food and Drug Administration Amendments Act requires results from clinical trials of Food and Drug Administration-approved drugs to be posted at ClinicalTrials.gov within 1 y after trial completion. We compared the timing and completeness of results of drug trials posted at ClinicalTrials.gov and published in journals. We searched ClinicalTrials.gov on March 27, 2012, for randomized controlled trials of drugs with posted results. For a random sample of these trials, we searched PubMed for corresponding publications. Data were extracted independently from ClinicalTrials.gov and from the published articles for trials with results both posted and published. We assessed the time to first public posting or publishing of results and compared the completeness of results posted at ClinicalTrials.gov versus published in journal articles. Completeness was defined as the reporting of all key elements, according to three experts, for the flow of participants, efficacy results, adverse events, and serious adverse events (e.g., for adverse events, reporting of the number of adverse events per arm, without restriction to statistically significant differences between arms for all randomized patients or for those who received at least one treatment dose). From the 600 trials with results posted at ClinicalTrials.gov, we randomly sampled 50% (n = 297) had no corresponding published article. For trials with both posted and published results (n = 202), the median time between primary completion date and first results publicly posted was 19 mo (first quartile = 14, third quartile = 30 mo), and the median time between primary completion date and journal publication was 21 mo (first quartile = 14, third quartile = 28 mo). Reporting was significantly more complete at ClinicalTrials.gov than in the published article for the flow of participants (64% versus 48% of trials, p<0.001), efficacy results (79% versus 69%, p = 0.02), adverse events (73% versus 45%, p<0.001), and serious adverse events (99% versus 63%, p<0.001). The main study limitation was that we considered only the publication describing the results for the primary outcomes. Our results highlight the need to search ClinicalTrials.gov for both unpublished and published trials. Trial results, especially serious adverse events, are more completely reported at ClinicalTrials.gov than in the published article.

Radiation: Physical Characterization and Environmental Measurements

NASA Technical Reports Server (NTRS)

1997-01-01

In this session, Session WP4, the discussion focuses on the following topics: Production of Neutrons from Interactions of GCR-Like Particles; Solar Particle Event Dose Distributions, Parameterization of Dose-Time Profiles; Assessment of Nuclear Events in the Body Produced by Neutrons and High-Energy Charged Particles; Ground-Based Simulations of Cosmic Ray Heavy Ion Interactions in Spacecraft and Planetary Habitat Shielding Materials; Radiation Measurements in Space Missions; Radiation Measurements in Civil Aircraft; Analysis of the Pre-Flight and Post-Flight Calibration Procedures Performed on the Liulin Space Radiation Dosimeter; and Radiation Environment Monitoring for Astronauts.

Saxagliptin versus glipizide as add-on therapy to metformin: assessment of hypoglycemia.

PubMed

Mintz, Matthew L; Minervini, Gianmaria

2014-05-01

To compare characteristics of hypoglycemic episodes in patients with type 2 diabetes receiving saxagliptin or glipizide add-on therapy to metformin. This was a post hoc analysis of an international, randomized, parallel-group, double-blind, active-controlled, phase 3 trial. The 52-week trial and 52-week extension were conducted from December 2007 to August 2010. Patients aged ≥18 years with glycated hemoglobin (HbA1c) >6.5% to 10.0% receiving stable metformin doses (≥1500 mg/d) were randomized 1:1 to add-on therapy with saxagliptin 5 mg/d or glipizide 5 to 20 mg/d (titrated to optimal effect or highest tolerable dose during the initial 18 weeks). Hypoglycemic episodes were recorded in patient diaries. Confirmed hypoglycemic events were defined as fingerstick glucose ≤50 mg/dL (≤2.8 mmol/L) with associated symptoms. Of 858 patients randomized, 428 received saxagliptin + metformin, and 430 received glipizide + metformin. Saxagliptin was noninferior to glipizide in lowering HbA1c. Hypoglycemia with saxagliptin + metformin and glipizide + metformin was reported by 15 (24 events) and 165 (896 events) patients, respectively, through week 104. The mean (SD) number of hypoglycemic events per patient reporting hypoglycemia was lower with saxagliptin + metformin versus glipizide + metformin through weeks 52 (1.5 [SD 0.88] vs 4.8 [SD 4.9], respectively) and 104 (1.6 [SD 0.99] vs 5.4 [SD 5.8]). Most patients receiving glipizide + metformin with hypoglycemia had multiple events (124/165 patients [75%]). Confirmed hypoglycemia, major events, and severe events occurred only with glipizide + metformin. Time to first hypoglycemic event was shorter with glipizide versus saxagliptin. Limitations of this analysis include its post hoc nature, a high rate of study discontinuation, and exclusion of patients with serious comorbidities and complications. Saxagliptin + metformin was associated with fewer patients reporting hypoglycemia and fewer and less severe hypoglycemic events in those experiencing hypoglycemia compared with glipizide + metformin. ClinicalTrials.gov registration number: NCT00575588.

Use of ultraviolet-fluorescence-based simulation in evaluation of personal protective equipment worn for first assessment and care of a patient with suspected high-consequence infectious disease.

PubMed

Hall, S; Poller, B; Bailey, C; Gregory, S; Clark, R; Roberts, P; Tunbridge, A; Poran, V; Evans, C; Crook, B

2018-06-01

Variations currently exist across the UK in the choice of personal protective equipment (PPE) used by healthcare workers when caring for patients with suspected high-consequence infectious diseases (HCIDs). To test the protection afforded to healthcare workers by current PPE ensembles during assessment of a suspected HCID case, and to provide an evidence base to justify proposal of a unified PPE ensemble for healthcare workers across the UK. One 'basic level' (enhanced precautions) PPE ensemble and five 'suspected case' PPE ensembles were evaluated in volunteer trials using 'Violet'; an ultraviolet-fluorescence-based simulation exercise to visualize exposure/contamination events. Contamination was photographed and mapped. There were 147 post-simulation and 31 post-doffing contamination events, from a maximum of 980, when evaluating the basic level of PPE. Therefore, this PPE ensemble did not afford adequate protection, primarily due to direct contamination of exposed areas of the skin. For the five suspected case ensembles, 1584 post-simulation contamination events were recorded, from a maximum of 5110. Twelve post-doffing contamination events were also observed (face, two events; neck, one event; forearm, one event; lower legs, eight events). All suspected case PPE ensembles either had post-doffing contamination events or other significant disadvantages to their use. This identified the need to design a unified PPE ensemble and doffing procedure, incorporating the most protective PPE considered for each body area. This work has been presented to, and reviewed by, key stakeholders to decide on a proposed unified ensemble, subject to further evaluation. Crown Copyright © 2018. Published by Elsevier Ltd. All rights reserved.

Post- and peritraumatic stress in disaster survivors: an explorative study about the influence of individual and event characteristics across different types of disasters

PubMed Central

Grimm, Anna; Hulse, Lynn; Preiss, Marek; Schmidt, Silke

2012-01-01

Background Examination of existing research on posttraumatic adjustment after disasters suggests that survivors’ posttraumatic stress levels might be better understood by investigating the influence of the characteristics of the event experienced on how people thought and felt, during the event as well as afterwards. Objective To compare survivors’ perceived post- and peritraumatic emotional and cognitive reactions across different types of disasters. Additionally, to investigate individual and event characteristics. Design In a European multi-centre study, 102 survivors of different disasters terror attack, flood, fire and collapse of a building were interviewed about their responses during the event. Survivors’ perceived posttraumatic stress levels were assessed with the Impact of Event Scale-Revised (IES-R). Peritraumatic emotional stress and risk perception were rated retrospectively. Influences of individual characteristics, such as socio-demographic data, and event characteristics, such as time and exposure factors, on post- and peritraumatic outcomes were analyzed. Results Levels of reported post- and peritraumatic outcomes differed significantly between types of disasters. Type of disaster was a significant predictor of all three outcome variables but the factors gender, education, time since event, injuries and fatalities were only significant for certain outcomes. Conclusion Results support the hypothesis that there are differences in perceived post- and peritraumatic emotional and cognitive reactions after experiencing different types of disasters. However, it should be noted that these findings were not only explained by the type of disaster itself but also by individual and event characteristics. As the study followed an explorative approach, further research paths are discussed to better understand the relationships between variables. PMID:22893839

Evaluation of Borama tuberculosis control program in Somaliland, Somalia.

PubMed

Qayad, Mohamed Gedi; Tarsitani, Gianfranco

2017-02-28

The Borama TB program in Somalia lost resources for TB operations in 2003. We evaluated the impact of the loss on the program. Pre-event (2002-2003) and post-event (2007) design were used. All TB patients registered in Borama and a sample of four months from Hargeisa (comparison) TB patients in both periods were abstracted. The following TB treatment outcomes were estimated: treatment success, treatment failure, case fatality, treatment interruption and transfer rates, along with percentage of patients with sputum specimen prior to treatment, percentage of patients from neighboring countries, and monthly average patients enrolled in treatment. The pre-event to post-event outcomes and measures were compared using descriptive and multivariate analyses. In total, 3,367 TB cases were abstracted. In Borama, the TB treatment success rate increased 6% in the post-event. The treatment failure and interruption rates both declined 75%. Monthly average TB patients declined 55%. Percentage of patients smear tested prior to the initiation of the treatment declined 9%. Percentage of TB patients from neighboring countries and other parts of Somalia declined 51%. Treatment interruption/transfer rates declined significantly in the post-event, compared to the pre-event period. Treatment failure/death rate did not change in the post-event period. In Hargeisa, the treatment success, failure/death, and interruption/transfer rates were similar in both periods. The RR did not change in these measures after adjusting for age and gender. This study indicates a significant setback to the Borama TB control program in the majority of measures evaluated, except the TB success rate.

Triggering Events and New Daily Persistent Headache: Age and Gender Differences and Insights on Pathogenesis-A Clinic-Based Study.

PubMed

Rozen, Todd D

2016-01-01

To define what are the age and gender differences for new daily persistent headache (NDPH) triggering events and how this may relate to the pathogenesis of NDPH. To describe several new triggering events for NDPH. All patients were diagnosed with primary NDPH at a headache specialty clinic during the time period of 01/2009 through 01/2013. This was a retrospective analysis of patient medical records utilizing an electronic medical record system. Ninety-seven patients were diagnosed with primary NDPH (65 women and 32 men). The mean average age of onset was younger in women than men 32.4 years vs 35.8 years. Fifty one of ninety seven NDPH patients (53%) did not recognize a triggering event while an infection or flu-like illness triggered NDPH in 22%, a stressful life event in 9%, a procedure (surgical) in 9%, and some "other" recognized trigger in 7%. All of the NDPH patients who developed new onset headache after an invasive surgical procedure were intubated. There was no significant difference in frequency for any of the triggering events between genders. The youngest age of onset was for a post stressful life event trigger while the oldest age of onset was in the post-surgical subgroup. Women developed NDPH at a younger age of onset for all recognized triggers, but there was no significant difference in ages of onset between the genders. There was no significant difference in the number of NDPH patients who had a history of migraine or no history and if they developed NDPH after any triggered event vs no triggering event. However, the majority of patients who developed NDPH after a stressful life event did have a precedent migraine history (67%). Newly noted triggers include: hormonal manipulation with progesterone, medication exposure, chemical/pesticide exposure, massage treatment, and immediately post a syncopal event. More than 50% of NDPH sufferers do not recognize a triggering event to their headaches. A key finding from the present study is the recognition that of those patients who developed NDPH after an invasive surgical procedure all required intubation and we speculate a cervicogenic origin to their headaches. The fact that both genders had an almost equal rate of occurrence for most NDPH triggers and almost the same age of onset suggests a common underlying pathogenesis for similar triggering events. A precedent history of migraine did not enhance the frequency of triggered vs nontriggered NDPH except possibly for a stressful life event. © 2015 American Headache Society.

The Psychological Consequences of Pre-Emigration Trauma and Post-Migration Stress in Refugees and Immigrants from Africa.

PubMed

Steel, Jennifer L; Dunlavy, Andrea C; Harding, Collette E; Theorell, Töres

2017-06-01

Over 50 million people have been displaced, some as a result of conflict, which exposure can lead to psychiatric sequelae. The aims of this study were to provide estimates of pre-emigration trauma, post-migration stress, and psychological sequelae of immigrants and refugees from predominantly Sub-Saharan Africa who immigrated to Sweden. We also examined the predictors of the psychiatric sequelae as well as acculturation within the host country. A total of 420 refugees and immigrants were enrolled using stratified quota sampling. A battery of questionnaires including the Harvard Trauma Questionnaire, Post-Migration Living Difficulties Scale, the Cultural Lifestyle Questionnaire; and the Hopkins Checklist were administered. Descriptive statistics, Chi square analyses, Pearson correlations, analysis of variance, and logistic and linear regression were performed to test the aims of the study. Eighty-nine percent of participants reported at least one traumatic experience prior to emigration. Forty-seven percent of refugees reported clinically significant PTSD and 20 % reported clinically significant depressive symptoms. Males reported a significantly greater number of traumatic events [F(1, 198) = 14.5, p < 0.001] and post-migration stress than females [F(1, 414) = 5.3, p = 0.02], particularly on the financial, discrimination, and healthcare subscales. Females reported a higher prevalence of depressive symptoms when compared to males [F(1, 419) = 3.9, p = 0.05]. Those with a shorter duration in Sweden reported higher rates of PTSD [F(63, 419) = 1.7, p < 0.001]. The greater number of traumatic events was found to be significantly associated with the severity of PTSD symptoms [F(34, 419) = 9.6, p < 0.001]. Using regression analysis, 82 and 83 % of the variances associated with anxiety and depression, respectively, was explained by gender, education, religion, PTSD and post-migration stress. Sixty-nine percent of the variance associated with PTSD included education, number of traumatic events, depressive symptoms and post-migration stress. Forty-seven percent of the variance for acculturation was accounted for by a model that included age, education, duration in Sweden, anxiety, depression, and post-migration stress. These predictors were also significant for employment status with the exception of depressive symptoms. Multidimensional interventions that provide treatments to improve psychiatric symptoms in combination with advocacy and support to reduce stress (e.g., financial, access to health care) are recommended. The focus of the intervention may also be modified based on the gender of the participants.

Recovery and resilience of tropical forests after disturbance.

PubMed

Cole, Lydia E S; Bhagwat, Shonil A; Willis, Katherine J

2014-05-20

The time taken for forested tropical ecosystems to re-establish post-disturbance is of widespread interest. Yet to date there has been no comparative study across tropical biomes to determine rates of forest re-growth, and how they vary through space and time. Here we present results from a meta-analysis of palaeoecological records that use fossil pollen as a proxy for vegetation change over the past 20,000 years. A total of 283 forest disturbance and recovery events, reported in 71 studies, are identified across four tropical regions. Results indicate that forests in Central America and Africa generally recover faster from past disturbances than those in South America and Asia, as do forests exposed to natural large infrequent disturbances compared with post-climatic and human impacts. Results also demonstrate that increasing frequency of disturbance events at a site through time elevates recovery rates, indicating a degree of resilience in forests exposed to recurrent past disturbance.

Developing Health-Based Pre-Planning Clearance Goals for Airport Remediation Following a Chemical Terrorist Attack: Decision Criteria for Multipathway Exposure Routes

PubMed Central

Watson, Annetta; Dolislager, Fredrick; Hall, Linda; Raber, Ellen; Hauschild, Veronique D.; Love, Adam H.

2011-01-01

In the event of a chemical terrorist attack on a transportation hub, post-event remediation and restoration activities necessary to attain unrestricted facility re-use and re-entry could require hours to multiple days. While timeframes are dependent on numerous variables, a primary controlling factor is the level of pre-planning and decision-making completed prior to chemical release. What follows is the second of a two-part analysis identifying key considerations, critical information and decision criteria to facilitate post-attack and post-decontamination consequence management activities. Decision criteria analysis presented here provides first-time, open-literature documentation of multi-pathway, health-based remediation exposure guidelines for selected toxic industrial compounds, chemical warfare agents, and agent degradation products for pre-planning application in anticipation of a chemical terrorist attack. Guideline values are provided for inhalation and direct ocular vapor exposure routes as well as percutaneous vapor, surface contact, and ingestion. Target populations include various employees as well as transit passengers. This work has been performed as a national case study conducted in partnership with the Los Angeles International Airport and The Bradley International Terminal. All recommended guidelines have been selected for consistency with airport scenario release parameters of a one-time, short-duration, finite airborne release from a single source followed by compound-specific decontamination. PMID:21399674

CD44 increases the efficiency of distant metastasis of breast cancer

PubMed Central

McFarlane, Suzanne; Coulter, Jonathan A.; Tibbits, Paul; O'Grady, Anthony; McFarlane, Cheryl; Montgomery, Nicola; Hill, Ashleigh; McCarthy, Helen O.; Young, Leonie S.; Kay, Elaine W.; Isacke, Clare M.; Waugh, David J.J.

2015-01-01

Metastasis is the predominant cause of death from cancer yet we have few biomarkers to predict patients at increased risk of metastasis and are unable to effectively treat disseminated disease. Analysis of 448 primary breast tumors determined that expression of the hylauronan receptor CD44 associated with high grade (p = 0.046), ER- (p = 0.001) and PR-negative tumors (p = 0.029), and correlated with increased distant recurrence and reduced disease-free survival in patients with lymph-node positive or large tumors. To determine its functional role in distant metastasis, CD44 was knocked-down in MDA-MB-231 cells using two independent shRNA sequences. Loss of CD44 attenuated tumor cell adhesion to endothelial cells and reduced cell invasion but did not affect proliferation in vitro. To verify the importance of CD44 to post-intravasation events, tumor formation was assessed by quantitative in vivo imaging and post-mortem tissue analysis following an intra-cardiac injection of transfected cells. CD44 knock-down increased survival and decreased overall tumor burden at multiple sites, including the skeleton in vivo. We conclude that elevated CD44 expression on tumour cells within the systemic circulation increases the efficiency of post-intravasation events and distant metastasis in vivo, consistent with its association with increased distant recurrence and reduced disease-free survival in patients. PMID:25888636

Developing health-based pre-planning clearance goals for airport remediation following a chemical terrorist attack: Decision criteria for multipathway exposure routes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Watson, Annetta Paule; Dolislager, Frederick; Hall, Dr. Linda

2011-01-01

In the event of a chemical terrorist attack on a transportation hub, post-event remediation and restoration activities necessary to attain unrestricted facility re-use and re-entry could require hours to multiple days. While timeframes are dependent on numerous variables, a primary controlling factor is the level of pre-planning and decision-making completed prior to chemical release. What follows is the second of a two-part analysis identifying key considerations, critical information and decision criteria to facilitate post-attack and post-decontamination consequence management activities. Decision criteria analysis presented here provides first-time, open-literature documentation of multi-pathway, health-based remediation exposure guidelines for selected toxic industrial compounds, chemicalmore » warfare agents, and agent degradation products for pre-planning application in anticipation of a chemical terrorist attack. Guideline values are provided for inhalation and direct ocular vapor exposure routes as well as percutaneous vapor, surface contact, and ingestion. Target populations include various employees as well as transit passengers. This work has been performed as a national case study conducted in partnership with the Los Angeles International Airport and The Bradley International Terminal. All recommended guidelines have been selected for consistency with airport scenario release parameters of a one-time, short-duration, finite airborne release from a single source followed by compound-specific decontamination.« less

Post-mortem clinical pharmacology

PubMed Central

Ferner, R E

2008-01-01

Clinical pharmacology assumes that deductions can be made about the concentrations of drugs from a knowledge of the pharmacokinetic parameters in an individual; and that the effects are related to the measured concentration. Post-mortem changes render the assumptions of clinical pharmacology largely invalid, and make the interpretation of concentrations measured in post-mortem samples difficult or impossible. Qualitative tests can show the presence of substances that were not present in life, and can fail to detect substances that led to death. Quantitative analysis is subject to error in itself, and because post-mortem concentrations vary in largely unpredictable ways with the site and time of sampling, as a result of the phenomenon of post-mortem redistribution. Consequently, compilations of ‘lethal concentrations’ are misleading. There is a lack of adequate studies of the true relationship between fatal events and the concentrations that can be measured subsequently, but without such studies, clinical pharmacologists and others should be wary of interpreting post-mortem measurements. PMID:18637886

DISCRN: A Distributed Storytelling Framework for Intelligence Analysis.

PubMed

Shukla, Manu; Dos Santos, Raimundo; Chen, Feng; Lu, Chang-Tien

2017-09-01

Storytelling connects entities (people, organizations) using their observed relationships to establish meaningful storylines. This can be extended to spatiotemporal storytelling that incorporates locations, time, and graph computations to enhance coherence and meaning. But when performed sequentially these computations become a bottleneck because the massive number of entities make space and time complexity untenable. This article presents DISCRN, or distributed spatiotemporal ConceptSearch-based storytelling, a distributed framework for performing spatiotemporal storytelling. The framework extracts entities from microblogs and event data, and links these entities using a novel ConceptSearch to derive storylines in a distributed fashion utilizing key-value pair paradigm. Performing these operations at scale allows deeper and broader analysis of storylines. The novel parallelization techniques speed up the generation and filtering of storylines on massive datasets. Experiments with microblog posts such as Twitter data and Global Database of Events, Language, and Tone events show the efficiency of the techniques in DISCRN.

Post-Exercise Heart Rate Recovery Independently Predicts Clinical Outcome in Patients with Acute Decompensated Heart Failure.

PubMed

Youn, Jong-Chan; Lee, Hye Sun; Choi, Suk-Won; Han, Seong-Woo; Ryu, Kyu-Hyung; Shin, Eui-Cheol; Kang, Seok-Min

2016-01-01

Post-exercise heart rate recovery (HRR) is an index of parasympathetic function associated with clinical outcome in patients with chronic heart failure. However, its relationship with the pro-inflammatory response and prognostic value in consecutive patients with acute decompensated heart failure (ADHF) has not been investigated. We measured HRR and pro-inflammatory markers in 107 prospectively and consecutively enrolled, recovered ADHF patients (71 male, 59 ± 15 years, mean ejection fraction 28.9 ± 14.2%) during the pre-discharge period. The primary endpoint included cardiovascular (CV) events defined as CV mortality, cardiac transplantation, or rehospitalization due to HF aggravation. The CV events occurred in 30 (28.0%) patients (5 cardiovascular deaths and 7 cardiac transplantations) during the follow-up period (median 214 days, 11-812 days). When the patients with ADHF were grouped by HRR according to the Contal and O'Quigley's method, low HRR was shown to be associated with significantly higher levels of serum monokine-induced by gamma interferon (MIG) and poor clinical outcome. Multivariate Cox regression analysis revealed that low HRR was an independent predictor of CV events in both enter method and stepwise method. The addition of HRR to a model significantly increased predictability for CV events across the entire follow-up period. Impaired post-exercise HRR is associated with a pro-inflammatory response and independently predicts clinical outcome in patients with ADHF. These findings may explain the relationship between autonomic dysfunction and clinical outcome in terms of the inflammatory response in these patients.

Safety evaluation of laninamivir octanoate hydrate through analysis of adverse events reported during early post-marketing phase vigilance.

PubMed

Nakano, Takashi; Okumura, Akihisa; Tanabe, Takuya; Niwa, Shimpei; Fukushima, Masato; Yonemochi, Rie; Eda, Hisano; Tsutsumi, Hiroyuki

2013-06-01

Abnormal behavior and delirium are common in children with influenza. While abnormal behavior and delirium are considered to be associated with influenza encephalopathy, an increased risk of such neuropsychiatric symptoms in patients receiving neuraminidase inhibitor treatment is suspected. Laninamivir octanoate hydrate, recently approved in Japan, is a long-acting neuraminidase inhibitor. It is important to establish a safety profile for laninamivir early, based on post-marketing experiences. Spontaneous safety reports collected in the early post-marketing phase vigilance were analyzed. Adverse events of interest such as abnormal behavior/delirium, dizziness/vertigo, respiratory disorders, shock/syncope, and any other serious events were intensively reviewed by the Safety Evaluation Committee. Abnormal behavior/delirium was a frequently reported event. Almost all the reported cases were considered to be due to influenza and not laninamivir. There were 32 cases of abnormal behavior/delirium that could lead to dangerous accidents, and these were observed more frequently in males and teenagers. Syncope probably related to the act of inhalation per se of laninamivir was reported during this survey. This safety review revealed that the safety profile of laninamivir for abnormal behavior/delirium and syncope was similar to that of other neuraminidase inhibitors. As stated in the labeling, teenage patients inhaling laninamivir should remain under constant parental supervision for at least 2 days and should be closely monitored for behavioral changes to prevent serious accidents associated with abnormal behavior/delirium. Furthermore, to avoid syncope because of inhalation, patients should be instructed to inhale in a relaxed sitting position.

Mental imagery and post-event processing in anticipation of a speech performance among socially anxious individuals.

PubMed

Brozovich, Faith A; Heimberg, Richard G

2013-12-01

The present study investigated whether post-event processing (PEP) involving mental imagery about a past speech is particularly detrimental for socially anxious individuals who are currently anticipating giving a speech. One hundred fourteen high and low socially anxious participants were told they would give a 5 min impromptu speech at the end of the experimental session. They were randomly assigned to one of three manipulation conditions: post-event processing about a past speech incorporating imagery (PEP-Imagery), semantic post-event processing about a past speech (PEP-Semantic), or a control condition, (n=19 per experimental group, per condition [high vs low socially anxious]). After the condition inductions, individuals' anxiety, their predictions of performance in the anticipated speech, and their interpretations of other ambiguous social events were measured. Consistent with predictions, high socially anxious individuals in the PEP-Imagery condition displayed greater anxiety than individuals in the other conditions immediately following the induction and before the anticipated speech task. They also interpreted ambiguous social scenarios in a more socially anxious manner than socially anxious individuals in the control condition. High socially anxious individuals made more negative predictions about their upcoming speech performance than low anxious participants in all conditions. The impact of imagery during post-event processing in social anxiety and its implications are discussed. © 2013.

'A Labour of Love': A King's College London Psychiatry Society Event to challenge the stigma attached to mental health problems in post-natal women.

PubMed

Hankir, Ahmed; Brothwood, Phillipa; Crocker, Bethany; Lim, Mao Fong; Lever, Isabel; Carrick, Frederick; Zaman, Rashid; Jones, Charlotte Wilson

2017-09-01

On the 9 th October 2000, Dr Daksha Emson, a London based psychiatrist with bipolar affective disorder, tragically killed herself and her three-month-old baby daughter during a psychotic episode. An independent inquiry into Dr Emson's death concluded that mental health stigma in the National Health Service was a factor that contributed to her death. Despite the morbidity and mortality attributed to the stigma attached to post-natal mental health problems there are very few programmes that have been developed to challenge it. King's College London Undergraduate Psychiatry Society organized an event entitled, 'A Labour of Love': Perinatal Mental Health to address this issue. The event included a talk from an expert by experience, a mother who developed post-partum mental health problems. We conducted a single-arm, pre-post comparison study on participants who attended the KCL Psych Soc event. Validated stigma scales on knowledge (Mental Health Knowledge Schedule (MAKS)), attitudes (Community Attitudes towards the Mentally Ill (CAMI)) and behaviour (Reported and Intended Behaviour Scale (RIBS)) were administered before and immediately after exposure to the event. 27/27 (100%) of participants recruited responded. There was a statistically significant difference in the pre-MAKS score compared to the post-MAKS score (p=0.0003), the pre-RIBS score compared to the post-RIBS score (p=0.0068) and in the pre-CAMI score compared to the post-CAMI score (p=0.0042). There were statistically significant reductions in stigma in the domains of knowledge, attitude and behavior following exposure to the KCL Psych Soc event and no adverse effects were reported. Our study revealed that a brief intervention made a highly significant impact and maybe useful in challenging the stigma around post-natal mental illness. However, more research in this area is required to determine if the changes are sustained before we can consider rolling out and scaling up such an initiative nationally and internationally.

Spatio-temporal trends of rainfall across Indian river basins

NASA Astrophysics Data System (ADS)

Bisht, Deepak Singh; Chatterjee, Chandranath; Raghuwanshi, Narendra Singh; Sridhar, Venkataramana

2018-04-01

Daily gridded high-resolution rainfall data of India Meteorological Department at 0.25° spatial resolution (1901-2015) was analyzed to detect the trend in seasonal, annual, and maximum cumulative rainfall for 1, 2, 3, and 5 days. The present study was carried out for 85 river basins of India during 1901-2015 and pre- and post-urbanization era, i.e., 1901-1970 and 1971-2015, respectively. Mann-Kendall ( α = 0.05) and Theil-Sen's tests were employed for detecting the trend and percentage of change over the period of time, respectively. Daily extreme rainfall events, above 95 and 99 percentile threshold, were also analyzed to detect any trend in their magnitude and number of occurrences. The upward trend was found for the majority of the sub-basins for 1-, 2-, 3-, and 5-day maximum cumulative rainfall during the post-urbanization era. The magnitude of extreme threshold events is also found to be increasing in the majority of the river basins during the post-urbanization era. A 30-year moving window analysis further revealed a widespread upward trend in a number of extreme threshold rainfall events possibly due to urbanization and climatic factors. Overall trends studied against intra-basin trend across Ganga basin reveal the mixed pattern of trends due to inherent spatial heterogeneity of rainfall, therefore, highlighting the importance of scale for such studies.

Adverse events and adherence to HIV post-exposure prophylaxis: a cohort study at the Korle-Bu Teaching Hospital in Accra, Ghana.

PubMed

Tetteh, Raymond A; Nartey, Edmund T; Lartey, Margaret; Mantel-Teeuwisse, Aukje K; Leufkens, Hubert G M; Nortey, Priscilla A; Dodoo, Alexander N O

2015-06-20

There is strong evidence that post-exposure prophylaxis (PEP) with antiretroviral drugs in the timely management of occupational exposures sustained by healthcare workers decreases the risk of HIV infection and PEP is now widely used. Antiretroviral drugs have well documented toxicities and produce adverse events in patients living with HIV/AIDS. In the era of "highly active antiretroviral therapy", non-adherence to treatment has been closely linked to the occurrence of adverse events in HIV patients and this ultimately influences treatment success but the influence of adverse events on adherence during PEP is less well studied. Following the introduction of a HIV post-exposure prophylaxis program in the Korle-Bu Teaching Hospital in January 2005, the incidence of adverse events and adherence were documented in occupationally-exposed healthcare workers (HCWs) and healthcare students (HCSs). Cohort event monitoring was used in following-up on exposed HCWs/HCSs for the two study outcomes; adverse events and adherence. All adverse events reported were grouped by MedDRA system organ classification and then by preferred term according to prophylaxis regimen. Adherence was determined by the completion of prophylaxis schedule. Cox proportional regression analysis was applied to determine the factors associated with the cohort study outcomes. Differences in frequencies were tested using the Chi square test and p < 0.05 was considered statistically significant. A total of 228 exposed HCWs/HCSs were followed up during the study, made up of 101 exposed HCWs/HCSs administered lamivudine/zidovudine (3TC/AZT) for 3 days; 75 exposed HCWs/HCSs administered lamivudine/zidovudine (3TC/AZT) for 28 days; and 52 exposed HCWs/HCSs administered lamivudine/zidovudine/lopinavir-ritonavir (3TC/AZT/LPV-RTV) for 28 days. The frequency of adverse events was 28% (n = 28) in exposed HCWs/HCSs administered 3TC/AZT for 3 days, 91% (n = 68) in exposed HCWs/HCSs administered 3TC/AZT for 28 days and 96% (n = 50) in exposed HCWs/HCSs administered 3TC/AZT/LPV-RTV for 28 days. Nausea was the most commonly reported adverse events in all three regimens. Adherence was complete in all exposed HCWs/HCSs administered 3TC/AZT for 3days, 56% (n = 42) in exposed HCWs/HCSs administered 3TC/AZT for 28 days and 62% (n = 32) in exposed HCWs/HCSs administered 3TC/AZT/LPV-RTV for 28 days. In the Cox regression multi-variate analysis, exposed HCWs/HCSs administered 3TC/AZT for 3 days were 70% less likely to report adverse events compared with exposed HCWs/HCSs administered 3TC/AZT for 28 days (Adjusted HR = 0.30 [95% CI, 0.18-0.48], p < 0.001). Exposed HCWs/HCSs administered 3TC/AZT for 3 days were 75% more likely to adhere to the schedule compared with exposed HCWs/HCSs administered 3TC/AZT for 28 days (Adjusted HR = 1.75 [95% CI, 1.16-2.66], p = 0.008). The intolerance to adverse events was cited as the sole reason for truncating PEP, thereby indicating the need for adequate, appropriate and effective counselling, education, active follow-up (possibly through mobile /phone contact) and management of adverse events. Education on the need to complete PEP schedule (especially for exposed HCWs/HCSs on 28-day schedule) can lead to increased adherence, which is very critical in minimizing the risk of HIV sero-conversion. The present results also indicate that cohort event monitoring could be an effective pharmacovigilance tool in monitoring adverse events in exposed HCWs/HCSs on HIV post-exposure prophylaxis.

Concurrent Bursty Behavior of Social Sensors in Sporting Events

PubMed Central

Takeichi, Yuki; Sasahara, Kazutoshi; Suzuki, Reiji; Arita, Takaya

2015-01-01

The advent of social media expands our ability to transmit information and connect with others instantly, which enables us to behave as “social sensors.” Here, we studied concurrent bursty behavior of Twitter users during major sporting events to determine their function as social sensors. We show that the degree of concurrent bursts in tweets (posts) and retweets (re-posts) works as a strong indicator of winning or losing a game. More specifically, our simple tweet analysis of Japanese professional baseball games in 2013 revealed that social sensors can immediately react to positive and negative events through bursts of tweets, but that positive events are more likely to induce a subsequent burst of retweets. We confirm that these findings also hold true for tweets related to Major League Baseball games in 2015. Furthermore, we demonstrate active interactions among social sensors by constructing retweet networks during a baseball game. The resulting networks commonly exhibited user clusters depending on the baseball team, with a scale-free connectedness that is indicative of a substantial difference in user popularity as an information source. While previous studies have mainly focused on bursts of tweets as a simple indicator of a real-world event, the temporal correlation between tweets and retweets implies unique aspects of social sensors, offering new insights into human behavior in a highly connected world. PMID:26659028

Predictors of birth-related post-traumatic stress symptoms: secondary analysis of a cohort study.

PubMed

Furuta, Marie; Sandall, Jane; Cooper, Derek; Bick, Debra

2016-12-01

This study aimed to identify factors associated with birth-related post-traumatic stress symptoms during the early postnatal period. Secondary analysis was conducted using data from a prospective cohort study of 1824 women who gave birth in one large hospital in England. Post-traumatic stress symptoms were measured by the Impact of Event Scale at 6 to 8 weeks postpartum. Zero-inflated negative binomial regression models were developed for analyses. Results showed that post-traumatic stress symptoms were more frequently observed in black women and in women who had a higher pre-pregnancy BMI compared to those with a lower BMI. Women who have a history of mental illness as well as those who gave birth before arriving at the hospital, underwent an emergency caesarean section or experienced severe maternal morbidity or neonatal complications also showed symptoms. Women's perceived control during labour and birth significantly reduced the effects of some risk factors. A higher level of perceived social support during the postnatal period also reduced the risk of post-traumatic stress symptoms. From the perspective of clinical practice, improving women's sense of control during labour and birth appears to be important, as does providing social support following the birth.

Lack of evidence for post-vaccine onset of autoimmune/lymphoproliferative disorders, during a nine-month follow-up in multiply vaccinated Italian military personnel.

PubMed

Ferlito, Claudia; Barnaba, Vincenzo; Abrignani, Sergio; Bombaci, Mauro; Sette, Alessandro; Sidney, John; Biselli, Roberto; Tomao, Enrico; Cattaruzza, Maria Sofia; Germano, Valentina; Biondo, Michela Ileen; Salerno, Gerardo; Lulli, Patrizia; Caporuscio, Sara; Picchianti Diamanti, Andrea; Falco, Mirella; Biselli, Valentina; Cardelli, Patrizia; Autore, Alberto; Lucertini, Elena; De Cesare, Donato Pompeo; Peragallo, Mario Stefano; Lista, Florigio; Martire, Carmela; Salemi, Simonetta; Nisini, Roberto; D'Amelio, Raffaele

2017-08-01

Anecdotal case reports, amplified by mass media and internet-based opinion groups, have recently indicated vaccinations as possibly responsible for autoimmunity/lymphoproliferation development. Multiply vaccinated Italian military personnel (group 1, operating in Italy, group 2, operating in Lebanon) were followed-up for nine months to monitor possible post-vaccine autoimmunity/lymphoproliferation onset. No serious adverse event was noticed in both groups. Multivariate analysis of intergroup differences only showed a significant association between lymphocyte increase and tetanus/diphtheria vaccine administration. A significant post-vaccine decrease in autoantibody positivity was observed. Autoantibodies were also studied by microarray analysis of self-proteins in subjects exposed to ≥4 concurrent vaccinations, without observing significant difference among baseline and one and nine months post-vaccine. Moreover, HLA-A2 subjects have been analyzed for the possible CD8T-cell response to apoptotic self-epitopes, without observing significant difference between baseline and one month post-vaccine. Multiple vaccinations in young adults are safe and not associated to autoimmunity/lymphoproliferation onset during a nine-month-long follow-up. Copyright © 2017 Elsevier Inc. All rights reserved.

Post-seismic relaxation following the 2009 April 6, L'Aquila (Italy), earthquake revealed by the mass position of a broad-band seismometer

NASA Astrophysics Data System (ADS)

Pino, Nicola Alessandro

2012-06-01

Post-seismic relaxation is known to occur after large or moderate earthquakes, on time scales ranging from days to years or even decades. In general, long-term deformation following seismic events has been detected by means of standard geodetic measurements, although seismic instruments are only used to estimate short timescale transient processes. Albeit inertial seismic sensors are also sensitive to rotation around their sensitive axes, the recording of very slow inclination of the ground surface at their standard output channels is practically impossible, because of their design characteristics. However, modern force-balance, broad-band seismometers provide the possibility to detect and measure slow surface inclination, through the analysis of the mass position signal. This output channel represents the integral of the broad-band velocity and is generally considered only for state-of-health diagnostics. In fact, the analysis of mass position data recorded at the time of the 2009 April 6, L'Aquila (MW= 6.3) earthquake, by a closely located STS-2 seismometer, evidenced the occurrence of a very low frequency signal, starting right at the time of the seismic event. This waveform is only visible on the horizontal components and is not related to the usual drift coupled with the temperature changes. This analysis suggests that the observed signal is to be ascribed to slowly developing ground inclination at the station site, caused by post-seismic relaxation following the main shock. The observed tilt reached 1.7 × 10-5 rad in about 2 months. This estimate is in very good agreement with the geodetic observations, giving comparable tilt magnitude and direction at the same site. This study represents the first seismic analysis ever for the mass position signal, suggesting useful applications for usually neglected data.

Hurricane impacts on forest resources in the Eastern United States: a post-sandy assessment

Treesearch

Greg C. Liknes; Susan J. Crocker; Randall S. Morin; Brian F. Walters

2015-01-01

Extreme weather events play a role in shaping the composition and structure of forests. Responding to and mitigating a storm event in a forested environment requires information about the location and severity of tree damage. However, this information can be difficult to obtain immediately following an event. Post-storm assessments using regularly collected forest...

Mindfulness and the attenuation of post-event processing in social phobia: an experimental investigation.

PubMed

Cassin, Stephanie E; Rector, Neil A

2011-01-01

The present experimental study examined the ability of metacognitive strategies to reduce the distress associated with post-event processing (PEP). Individuals with DSM-IV generalized social phobia (N = 57) were randomly allocated to receive brief training in mindfulness, distraction, or no training (control group). Next, they underwent an experimental PEP induction. Following the induction, they were instructed to apply the metacognitive strategy (mindfulness or distraction) they were taught or to continue thinking about the social event the way they typically would following such an event (control). Participants rated their distress on a visual analogue scale prior to the PEP induction, and then every minute for 5 min while applying the metacognitive strategy. They also rated their affect immediately after applying the metacognitive strategy. Results suggest that mindfulness reduces distress significantly over the post-event period and results in significantly more positive affect than when receiving no training. In contrast, distraction does not reduce distress over the post-event period performs comparable to receiving no training. The results of this experimental investigation suggest that mindfulness has the potential to reduce distress associated with PEP and provide further support for the clinical utility of mindfulness in the treatment of generalized social phobia.

Analyzing and Identifying Teens' Stressful Periods and Stressor Events From a Microblog.

PubMed

Li, Qi; Xue, Yuanyuan; Zhao, Liang; Jia, Jia; Feng, Ling

2017-09-01

Increased health problems among adolescents caused by psychological stress have aroused worldwide attention. Long-standing stress without targeted assistance and guidance negatively impacts the healthy growth of adolescents, threatening the future development of our society. So far, research focused on detecting adolescent psychological stress revealed from each individual post on microblogs. However, beyond stressful moments, identifying teens' stressful periods and stressor events that trigger each stressful period is more desirable to understand the stress from appearance to essence. In this paper, we define the problem of identifying teens' stressful periods and stressor events from the open social media microblog. Starting from a case study of adolescents' posting behaviors during stressful school events, we build a Poisson-based probability model for the correlation between stressor events and stressful posting behaviors through a series of posts on Tencent Weibo (referred to as the microblog throughout the paper). With the model, we discover teens' maximal stressful periods and further extract details of possible stressor events that cause the stressful periods. We generalize and present the extracted stressor events in a hierarchy based on common stress dimensions and event types. Taking 122 scheduled stressful study-related events in a high school as the ground truth, we test the approach on 124 students' posts from January 1, 2012 to February 1, 2015 and obtain some promising experimental results: (stressful periods: recall 0.761, precision 0.737, and F 1 -measure 0.734) and (top-3 stressor events: recall 0.763, precision 0.756, and F 1 -measure 0.759). The most prominent stressor events extracted are in the self-cognition domain, followed by the school life domain. This conforms to the adolescent psychological investigation result that problems in school life usually accompanied with teens' inner cognition problems. Compared with the state-of-the-art top-1 personal life event detection approach, our stressor event detection method is 13.72% higher in precision, 19.18% higher in recall, and 16.50% higher in F 1 -measure, demonstrating the effectiveness of our proposed framework.

Application of Haddon's matrix in qualitative research methodology: an experience in burns epidemiology.

PubMed

Deljavan, Reza; Sadeghi-Bazargani, Homayoun; Fouladi, Nasrin; Arshi, Shahnam; Mohammadi, Reza

2012-01-01

Little has been done to investigate the application of injury specific qualitative research methods in the field of burn injuries. The aim of this study was to use an analytical tool (Haddon's matrix) through qualitative research methods to better understand people's perceptions about burn injuries. This study applied Haddon's matrix as a framework and an analytical tool for a qualitative research methodology in burn research. Both child and adult burn injury victims were enrolled into a qualitative study conducted using focus group discussion. Haddon's matrix was used to develop an interview guide and also through the analysis phase. The main analysis clusters were pre-event level/human (including risky behaviors, belief and cultural factors, and knowledge and education), pre-event level/object, pre-event phase/environment and event and post-event phase (including fire control, emergency scald and burn wound management, traditional remedies, medical consultation, and severity indicators). This research gave rise to results that are possibly useful both for future injury research and for designing burn injury prevention plans. Haddon's matrix is applicable in a qualitative research methodology both at data collection and data analysis phases. The study using Haddon's matrix through a qualitative research methodology yielded substantially rich information regarding burn injuries that may possibly be useful for prevention or future quantitative research.

Defining Tsunami Magnitude as Measure of Potential Impact

NASA Astrophysics Data System (ADS)

Titov, V. V.; Tang, L.

2016-12-01

The goal of tsunami forecast, as a system for predicting potential impact of a tsunami at coastlines, requires quick estimate of a tsunami magnitude. This goal has been recognized since the beginning of tsunami research. The work of Kajiura, Soloviev, Abe, Murty, and many others discussed several scales for tsunami magnitude based on estimates of tsunami energy. However, difficulties of estimating tsunami energy based on available tsunami measurements at coastal sea-level stations has carried significant uncertainties and has been virtually impossible in real time, before tsunami impacts coastlines. The slow process of tsunami magnitude estimates, including collection of vast amount of available coastal sea-level data from affected coastlines, made it impractical to use any tsunami magnitude scales in tsunami warning operations. Uncertainties of estimates made tsunami magnitudes difficult to use as universal scale for tsunami analysis. Historically, the earthquake magnitude has been used as a proxy of tsunami impact estimates, since real-time seismic data is available of real-time processing and ample amount of seismic data is available for an elaborate post event analysis. This measure of tsunami impact carries significant uncertainties in quantitative tsunami impact estimates, since the relation between the earthquake and generated tsunami energy varies from case to case. In this work, we argue that current tsunami measurement capabilities and real-time modeling tools allow for establishing robust tsunami magnitude that will be useful for tsunami warning as a quick estimate for tsunami impact and for post-event analysis as a universal scale for tsunamis inter-comparison. We present a method for estimating the tsunami magnitude based on tsunami energy and present application of the magnitude analysis for several historical events for inter-comparison with existing methods.

77 FR 30996 - Taking and Importing Marine Mammals: Taking Marine Mammals Incidental to Navy's Research...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-24

... mammals were seen using shore- based survey during the pre- and post-event surveys. No marine mammals were... for both the pre and post surveys. The survey vessel was the NS-50 small range craft and it was used for pre- and post-event monitoring. The NS-50 vessel crew consisted of a Craft master, marine mammal...

A Power-Law Growth and Decay Model with Autocorrelation for Posting Data to Social Networking Services.

PubMed

Fujiyama, Toshifumi; Matsui, Chihiro; Takemura, Akimichi

2016-01-01

We propose a power-law growth and decay model for posting data to social networking services before and after social events. We model the time series structure of deviations from the power-law growth and decay with a conditional Poisson autoregressive (AR) model. Online postings related to social events are described by five parameters in the power-law growth and decay model, each of which characterizes different aspects of interest in the event. We assess the validity of parameter estimates in terms of confidence intervals, and compare various submodels based on likelihoods and information criteria.

Collapse Mechanisms Of Masonry Structures

NASA Astrophysics Data System (ADS)

Zuccaro, G.; Rauci, M.

2008-07-01

The paper outlines a possible approach to typology recognition, safety check analyses and/or damage measuring taking advantage by a multimedia tool (MEDEA), tracing a guided procedure useful for seismic safety check evaluation and post event macroseismic assessment. A list of the possible collapse mechanisms observed in the post event surveys on masonry structures and a complete abacus of the damages are provided in MEDEA. In this tool a possible combination between a set of damage typologies and each collapse mechanism is supplied in order to improve the homogeneity of the damages interpretation. On the other hand recent researches of one of the author have selected a number of possible typological vulnerability factors of masonry buildings, these are listed in the paper and combined with potential collapse mechanisms to be activated under seismic excitation. The procedure takes place from simple structural behavior models, derived from the Umbria-Marche earthquake observations, and tested after the San Giuliano di Puglia event; it provides the basis either for safety check analyses of the existing buildings or for post-event structural safety assessment and economic damage evaluation. In the paper taking advantage of MEDEA mechanisms analysis, mainly developed for the post event safety check surveyors training, a simple logic path is traced in order to approach the evaluation of the masonry building safety check. The procedure starts from the identification of the typological vulnerability factors to derive the potential collapse mechanisms and their collapse multipliers and finally addresses the simplest and cheapest strengthening techniques to reduce the original vulnerability. The procedure has been introduced in the Guide Lines of the Regione Campania for the professionals in charge of the safety check analyses and the buildings strengthening in application of the national mitigation campaign introduced by the Ordinance of the Central Government n. 3362/03. The main cases of out of plane mechanisms are analyzed and a possible innovative theory for masonry building vulnerability assessment, based on limit state analyses, is outlined. The paper report the first step of a research granted by the Department of the Civil Protection to Reluis within the research program of Line 10.

Collapse Mechanisms Of Masonry Structures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zuccaro, G.; Rauci, M.

2008-07-08

The paper outlines a possible approach to typology recognition, safety check analyses and/or damage measuring taking advantage by a multimedia tool (MEDEA), tracing a guided procedure useful for seismic safety check evaluation and post event macroseismic assessment. A list of the possible collapse mechanisms observed in the post event surveys on masonry structures and a complete abacus of the damages are provided in MEDEA. In this tool a possible combination between a set of damage typologies and each collapse mechanism is supplied in order to improve the homogeneity of the damages interpretation. On the other hand recent researches of onemore » of the author have selected a number of possible typological vulnerability factors of masonry buildings, these are listed in the paper and combined with potential collapse mechanisms to be activated under seismic excitation. The procedure takes place from simple structural behavior models, derived from the Umbria-Marche earthquake observations, and tested after the San Giuliano di Puglia event; it provides the basis either for safety check analyses of the existing buildings or for post-event structural safety assessment and economic damage evaluation. In the paper taking advantage of MEDEA mechanisms analysis, mainly developed for the post event safety check surveyors training, a simple logic path is traced in order to approach the evaluation of the masonry building safety check. The procedure starts from the identification of the typological vulnerability factors to derive the potential collapse mechanisms and their collapse multipliers and finally addresses the simplest and cheapest strengthening techniques to reduce the original vulnerability. The procedure has been introduced in the Guide Lines of the Regione Campania for the professionals in charge of the safety check analyses and the buildings strengthening in application of the national mitigation campaign introduced by the Ordinance of the Central Government n. 3362/03. The main cases of out of plane mechanisms are analyzed and a possible innovative theory for masonry building vulnerability assessment, based on limit state analyses, is outlined. The paper report the first step of a research granted by the Department of the Civil Protection to Reluis within the research program of Line 10.« less

A prospective population based study of changes in alcohol use and binge drinking after a mass traumatic event*

PubMed Central

Cerdá, Magdalena; Tracy, Melissa; Galea, Sandro

2010-01-01

Few studies have assessed changes in alcohol use before and after a massive disaster. We investigated the contribution of exposure to traumatic events and stressors related to Hurricanes Katrina and Rita to alcohol use and binge drinking. We used data from the Panel Study of Income Dynamics collected in Mississippi, Louisiana and Alabama on adults aged 18–85 (n=439): 1) data from 1968–2005 on household income; 2) data from 2005 and 2007 on total number of drinks per year and number of days the respondent binged; and 3) data from 2007 on exposure to hurricane-related traumatic events and post-hurricane stressors. Exposure to each additional hurricane-related traumatic event was associated with 79.2 more drinks and 2.46 times higher odds of binge drinking for more days in the past year (95% CI: 1.09, 5.55), while more post-disaster stressors were associated with 16.5 more drinks and 1.23 times higher odds of binge drinking for more days in the past year (95% CI: 0.99, 1.51). Respondents who had followed a lower lifetime income trajectory and were exposed to more lifetime traumatic events experienced the highest risk of reporting increased alcohol use given exposure to hurricane-related traumatic events and post-hurricane stressors. Disaster-related traumatic events and the proliferation of post-disaster stressors may result in increased post-disaster alcohol use and abuse. Disaster-related exposures may have a particularly strong impact among individuals with a history of social and economic adversity, widening preexisting health disparities. PMID:20977977

Implementation of a Post-Code Pause: Extending Post-Event Debriefing to Include Silence.

PubMed

Copeland, Darcy; Liska, Heather

2016-01-01

This project arose out of a need to address two issues at our hospital: we lacked a formal debriefing process for code/trauma events and the emergency department wanted to address the psychological and spiritual needs of code/trauma responders. We developed a debriefing process for code/trauma events that intentionally included mechanisms to facilitate recognition, acknowledgment, and, when needed, responses to the psychological and spiritual needs of responders. A post-code pause process was implemented in the emergency department with the aims of standardizing a debriefing process, encouraging a supportive team-based culture, improving transition back to "normal" activities after responding to code/trauma events, and providing responders an opportunity to express reverence for patients involved in code/trauma events. The post-code pause process incorporates a moment of silence and the addition of two simple questions to a traditional operational debrief. Implementation of post-code pauses was feasible despite the fast paced nature of the department. At the end of the 1-year pilot period, staff members reported increases in feeling supported by peers and leaders, their ability to pay homage to patients, and having time to regroup prior to returning to their assignment. There was a decrease in the number of respondents reporting having thoughts or feelings associated with the event within 24 hr. The pauses create a mechanism for operational team debriefing, provide an opportunity for staff members to honor their work and their patients, and support an environment in which the psychological and spiritual effects of responding to code/trauma events can be acknowledged.

Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets

PubMed Central

Maciejewski, Mateusz; Lounkine, Eugen; Whitebread, Steven; Farmer, Pierre; DuMouchel, William; Shoichet, Brian K; Urban, Laszlo

2017-01-01

The Food and Drug Administration Adverse Event Reporting System (FAERS) remains the primary source for post-marketing pharmacovigilance. The system is largely un-curated, unstandardized, and lacks a method for linking drugs to the chemical structures of their active ingredients, increasing noise and artefactual trends. To address these problems, we mapped drugs to their ingredients and used natural language processing to classify and correlate drug events. Our analysis exposed key idiosyncrasies in FAERS, for example reports of thalidomide causing a deadly ADR when used against myeloma, a likely result of the disease itself; multiplications of the same report, unjustifiably increasing its importance; correlation of reported ADRs with public events, regulatory announcements, and with publications. Comparing the pharmacological, pharmacokinetic, and clinical ADR profiles of methylphenidate, aripiprazole, and risperidone, and of kinase drugs targeting the VEGF receptor, demonstrates how underlying molecular mechanisms can emerge from ADR co-analysis. The precautions and methods we describe may enable investigators to avoid confounding chemistry-based associations and reporting biases in FAERS, and illustrate how comparative analysis of ADRs can reveal underlying mechanisms. DOI: http://dx.doi.org/10.7554/eLife.25818.001 PMID:28786378

A community responds to collective trauma: an ecological analysis of the James Byrd murder in Jasper, Texas.

PubMed

Wicke, Thomas; Silver, Roxane Cohen

2009-12-01

The brutal murder of James Byrd Jr. in June 1998 unleashed a storm of media, interest groups, high profile individuals and criticism on the Southeast Texas community of Jasper. The crime and subsequent response-from within the community as well as across the world-engulfed the entire town in a collective trauma. Using natural disaster literature/theory and employing an ecological approach, Jasper, Texas was investigated via an interrupted time series analysis to identify how the community changed as compared to a control community (Center, Texas) on crime, economic, health, educational, and social capital measures collected at multiple pre- and post-crime time points between 1995 and 2003. Differences-in-differences (DD) analysis revealed significant post-event changes in Jasper, as well as a surprising degree of resilience and lack of negative consequences. Interviews with residents conducted between March 2005 and 2007 identified how the community responded to the crisis and augmented quantitative findings with qualitative, field-informed interpretation. Interviews suggest the intervention of external organizations exacerbated the severity of the events. However, using strengths of specific local social institutions-including faith based, law enforcement, media, business sector and civic government organizations-the community effectively responded to the initial threat and to the potential negative ramifications of external entities.

Post Fire Vegetation Recovery in Greece after the large Drought event of 2007

NASA Astrophysics Data System (ADS)

Gouveia, Célia M.; Bastos, Ana; DaCamara, Carlos; Trigo, Ricardo

2013-04-01

Fire is a natural factor of Mediterranean ecosystems. However, fire regimes in the European Mediterranean areas have been changing in the last decades, mainly due to land-use changes and climate driven factors possibly associated with climatic warming (e.g. decline of precipitation, increasing temperatures but also higher frequency of heatwaves). In Greece, the fire season of 2007 was particularly devastating, achieving the new all-time record of estimated burnt area (225 734 ha), since 1980. Additionally, we must stress that prior to the summer fire season in 2007, Greece suffered an exceptional drought event. This severe drought had a strong negative impact in vegetation dynamics. Since water availability is a crucial factor in post-fire vegetation recovery, it is desirable to assess the impact that such water-stress conditions had on fire sensitivity and post-fire vegetation recovery. Based on monthly values of NDVI, at the 1km×1km spatial scale, as obtained from the VEGETATION-SPOT5 instrument, from 1999 to 2010, large burnt scars are identified in Greece, during 2007 fire season. Vegetation recovery is then assessed based on a mono parametric regression model originally developed by Gouveia et al. (2010) to identify large burnt scars in Portugal during the 2003 fire season and after applied to 2005 fire season (Bastos et al., 2012). Some large burnt areas are selected and the respective NDVI behaviour is monitored throughout the pre and the post fire period. The vegetation dynamics during the pre-fire period is analysed and related to the extreme climatic events that characterised the considered period. An analysis is made of the dependence of recovery rates on land cover types and fire damage. Finally results are compared to results already obtained for Portugal (Gouveia et al. 2010). This work emphasises the use of a simple methodology, when applied to low resolution satellite imagery in order to monitor vegetation recovery after large fires events over distinct regions of Mediterranean Europe. Gouveia C., DaCamara C.C, Trigo R.M. (2010). "Post-fire vegetation dynamics in Portugal". Natural Hazards and Earth System Sciences, 10, 4, 673-684. Bastos A., Gouveia C., DaCamara C.C., and Trigo R.M.: Modelling post-fire vegetation recovery in Portugal.Biogeosciences, 8, 4559-4601, 2011.

Real-time analysis of Drosophila post-embryonic haemocyte behaviour.

PubMed

Sampson, Christopher J; Williams, Michael J

2012-01-01

The larval stage of the model organism Drosophila is frequently used to study host-pathogen interactions. During embryogenesis the cellular arm of the immune response, consisting of macrophage-like cells known as plasmatocytes, is extremely motile and functions to phagocytise pathogens and apoptotic bodies, as well as produce extracellular matrix. The cellular branch of the larval (post-embryonic) innate immune system consists of three cell types--plasmatocytes, crystal cells and lamellocytes--which are involved in the phagocytosis, encapsulation and melanisation of invading pathogens. Post-embryonic haemocyte motility is poorly understood thus further characterisation is required, for the purpose of standardisation. In order to examine post-embryonic haemocyte cytoskeletal dynamics or migration, the most commonly used system is in vitro cell lines. The current study employs an ex vivo system (an adaptation of in vitro cell incubation using primary cells), in which primary larval or pre-pupal haemocytes are isolated for short term analysis, in order to discover various aspects of their behaviour during events requiring cytoskeleton dynamics. The ex vivo method allows for real-time analysis and manipulation of primary post-embryonic haemocytes. This technique was used to characterise, and potentially standardised, larval and pre-pupal haemocyte cytoskeleton dynamics, assayed on different extracellular matrices. Using this method it was determined that, while larval haemocytes are unable to migrate, haemocytes recovered from pre-pupae are capable of migration.

Acoustic emission characterization of microcracking in laboratory-scale hydraulic fracturing tests

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hampton, Jesse; Gutierrez, Marte; Matzar, Luis

Understanding microcracking near coalesced fracture generation is critically important for hydrocarbon and geothermal reservoir characterization as well as damage evaluation in civil engineering structures. Dense and sometimes random microcracking near coalesced fracture formation alters the mechanical properties of the nearby virgin material. Individual microcrack characterization is also significant in quantifying the material changes near the fracture faces (i.e. damage). Acoustic emission (AE) monitoring and analysis provide unique information regarding the microcracking process temporally, and information concerning the source characterization of individual microcracks can be extracted. In this context, laboratory hydraulic fracture tests were carried out while monitoring the AEs frommore » several piezoelectric transducers. In-depth post-processing of the AE event data was performed for the purpose of understanding the individual source mechanisms. Several source characterization techniques including moment tensor inversion, event parametric analysis, and volumetric deformation analysis were adopted. Post-test fracture characterization through coring, slicing and micro-computed tomographic imaging was performed to determine the coalesced fracture location and structure. Distinct differences in fracture characteristics were found spatially in relation to the openhole injection interval. Individual microcrack AE analysis showed substantial energy reduction emanating spatially from the injection interval. Lastly, it was quantitatively observed that the recorded AE signals provided sufficient information to generalize the damage radiating spatially away from the injection wellbore.« less

Acoustic emission characterization of microcracking in laboratory-scale hydraulic fracturing tests

DOE PAGES

Hampton, Jesse; Gutierrez, Marte; Matzar, Luis; ...

2018-06-11

Understanding microcracking near coalesced fracture generation is critically important for hydrocarbon and geothermal reservoir characterization as well as damage evaluation in civil engineering structures. Dense and sometimes random microcracking near coalesced fracture formation alters the mechanical properties of the nearby virgin material. Individual microcrack characterization is also significant in quantifying the material changes near the fracture faces (i.e. damage). Acoustic emission (AE) monitoring and analysis provide unique information regarding the microcracking process temporally, and information concerning the source characterization of individual microcracks can be extracted. In this context, laboratory hydraulic fracture tests were carried out while monitoring the AEs frommore » several piezoelectric transducers. In-depth post-processing of the AE event data was performed for the purpose of understanding the individual source mechanisms. Several source characterization techniques including moment tensor inversion, event parametric analysis, and volumetric deformation analysis were adopted. Post-test fracture characterization through coring, slicing and micro-computed tomographic imaging was performed to determine the coalesced fracture location and structure. Distinct differences in fracture characteristics were found spatially in relation to the openhole injection interval. Individual microcrack AE analysis showed substantial energy reduction emanating spatially from the injection interval. Lastly, it was quantitatively observed that the recorded AE signals provided sufficient information to generalize the damage radiating spatially away from the injection wellbore.« less

Timing and Completeness of Trial Results Posted at ClinicalTrials.gov and Published in Journals

PubMed Central

Riveros, Carolina; Dechartres, Agnes; Perrodeau, Elodie; Haneef, Romana; Boutron, Isabelle; Ravaud, Philippe

2013-01-01

Background The US Food and Drug Administration Amendments Act requires results from clinical trials of Food and Drug Administration–approved drugs to be posted at ClinicalTrials.gov within 1 y after trial completion. We compared the timing and completeness of results of drug trials posted at ClinicalTrials.gov and published in journals. Methods and Findings We searched ClinicalTrials.gov on March 27, 2012, for randomized controlled trials of drugs with posted results. For a random sample of these trials, we searched PubMed for corresponding publications. Data were extracted independently from ClinicalTrials.gov and from the published articles for trials with results both posted and published. We assessed the time to first public posting or publishing of results and compared the completeness of results posted at ClinicalTrials.gov versus published in journal articles. Completeness was defined as the reporting of all key elements, according to three experts, for the flow of participants, efficacy results, adverse events, and serious adverse events (e.g., for adverse events, reporting of the number of adverse events per arm, without restriction to statistically significant differences between arms for all randomized patients or for those who received at least one treatment dose). From the 600 trials with results posted at ClinicalTrials.gov, we randomly sampled 50% (n = 297) had no corresponding published article. For trials with both posted and published results (n = 202), the median time between primary completion date and first results publicly posted was 19 mo (first quartile = 14, third quartile = 30 mo), and the median time between primary completion date and journal publication was 21 mo (first quartile = 14, third quartile = 28 mo). Reporting was significantly more complete at ClinicalTrials.gov than in the published article for the flow of participants (64% versus 48% of trials, p<0.001), efficacy results (79% versus 69%, p = 0.02), adverse events (73% versus 45%, p<0.001), and serious adverse events (99% versus 63%, p<0.001). The main study limitation was that we considered only the publication describing the results for the primary outcomes. Conclusions Our results highlight the need to search ClinicalTrials.gov for both unpublished and published trials. Trial results, especially serious adverse events, are more completely reported at ClinicalTrials.gov than in the published article. Please see later in the article for the Editors' Summary PMID:24311990

29 CFR 4043.33 - Application for minimum funding waiver.

Code of Federal Regulations, 2011 CFR

2011-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.33 Application for minimum funding waiver. (a) Reportable event. A reportable event for a...

29 CFR 4043.33 - Application for minimum funding waiver.

Code of Federal Regulations, 2010 CFR

2010-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.33 Application for minimum funding waiver. (a) Reportable event. A reportable event for a...

29 CFR 4043.33 - Application for minimum funding waiver.

Code of Federal Regulations, 2014 CFR

2014-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.33 Application for minimum funding waiver. (a) Reportable event. A reportable event for a...

29 CFR 4043.33 - Application for minimum funding waiver.

Code of Federal Regulations, 2012 CFR

2012-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.33 Application for minimum funding waiver. (a) Reportable event. A reportable event for a...

29 CFR 4043.33 - Application for minimum funding waiver.

Code of Federal Regulations, 2013 CFR

2013-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.33 Application for minimum funding waiver. (a) Reportable event. A reportable event for a...

Modeling four occurred debris flow events in the Dolomites area (North-Eastern Italian Alps)

NASA Astrophysics Data System (ADS)

Boreggio, Mauro; Gregoretti, Carlo; Degetto, Massimo; Bernard, Martino

2016-04-01

Four occurred debris flows in the Dolomites area (North-Eastern Italian Alps) are modeled by back-analysis. The four debris flows events are those occurred at Rio Lazer (Trento) on the 4th of November 1966, at Fiames (Belluno) on the 5th of July 2006, at Rovina di Cancia (Belluno) on the 18th of July 2009 and at Rio Val Molinara (Trento) on the 15th of August 2010. In all the events, runoff entrained sediments present on natural channels and formed a solid-liquid wave that routed downstream. The first event concerns the routing of debris flow on an inhabited fan. The second event the deviation of debris flow from the usual path due to an obstruction with the excavation of a channel in the scree and the downstream spreading in a wood. The third event concerns the routing of debris flow in a channel with an ending the reservoir, its overtopping and final spreading in the inhabited area. The fourth event concerns the routing of debris flow along the main channel downstream the initiation area until spreading just upstream a village. All the four occurred debris flows are simulated by modeling runoff that entrained debris flow for determining the solid-liquid hydrograph. The routing of the solid-liquid hydrograph is simulated by a bi-phase cell model based on the kinematic approach. The comparison between simulated and measured erosion and deposition depths is satisfactory. Nearly the same parameters for computing erosion and deposition were used for all the four occurred events. The maps of erosion and deposition depths are obtained by comparing the results of post-event surveys with the pre-event DEM. The post-event surveys were conducted by using different instruments (LiDAR and GPS) or the combination photos-single points depth measurements (in this last case it is possible obtaining the deposition/erosion depths by means of stereoscopy techniques).

Blog Posting After Lung Cancer Notification: Content Analysis of Blogs Written by Patients or Their Families.

PubMed

Sato, Akira; Aramaki, Eiji; Shimamoto, Yumiko; Tanaka, Shiro; Kawakami, Koji

2015-05-18

The advent and spread of the Internet has changed the way societies communicate. A portion of information on the Internet may constitute an important source of information concerning the experiences and thoughts of patients and their families. Patients and their families use blogs to obtain updated information, search for alternative treatments, facilitate communication with other patients, and receive emotional support. However, much of this information has yet to be actively utilized by health care professionals. We analyzed health-related information in blogs from Japan, focusing on the feelings and satisfaction levels of lung cancer patients or their family members after being notified of their disease. We collected 100 blogs written in Japanese by patients (or their families) who had been diagnosed with lung cancer by a physician. These 100 blogs posts were searchable between June 1 and June 30, 2013. We focused on blog posts that addressed the lung cancer notification event. We analyzed the data using two different approaches (Analysis A and Analysis B). Analysis A was blog content analysis in which we analyzed the content addressing the disease notification event in each blog. Analysis B was patient's dissatisfaction and anxiety analysis. Detailed blog content regarding patient's dissatisfaction and anxiety at the individual sentence level was coded and analyzed. The 100 blog posts were written by 48 men, 46 women, and 6 persons whose sex was undisclosed. The average age of the blog authors was 52.4 years. With regard to cancer staging, there were 5 patients at Stage I, 3 patients at Stage II, 14 patients at Stage III, 21 patients at Stage IV, and 57 patients without a disclosed cancer stage. The results of Analysis A showed that the proportion of patients who were dissatisfied with the level of health care exceeded that of satisfied patients (22% vs 8%). From the 2499 sentences in the 100 blog posts analyzed, we identified expressions of dissatisfaction and anxiety in 495 sentences. Our results showed that there were substantially more posts concerning "Way of living, reasons for living, set of values" and "Relationships with medical staff (own hospital)" than in previous studies (Analysis B). This study provides insight into the feelings of dissatisfaction and anxieties held by lung cancer patients and their families, including those regarding the "Way of living, reasons for living, set of values" and "Relationship with medical staff (own hospital)," which were inaccessible in previous survey analyses. When comparing information obtained from patients' voluntary records and those from previous surveys conducted by health care institutions, it is likely that the former would be more indicative of patients' actual opinions and feelings. Therefore, it is important to utilize such records as an information resource. ©Akira Sato, Eiji Aramaki, Yumiko Shimamoto, Shiro Tanaka, Koji Kawakami. , 18.05.2015.

Radar rainfall estimation in the context of post-event analysis of flash-flood events

NASA Astrophysics Data System (ADS)

Delrieu, G.; Bouilloud, L.; Boudevillain, B.; Kirstetter, P.-E.; Borga, M.

2009-09-01

This communication is about a methodology for radar rainfall estimation in the context of post-event analysis of flash-flood events developed within the HYDRATE project. For such extreme events, some raingauge observations (operational, amateur) are available at the event time scale, while few raingauge time series are generally available at the hydrologic time steps. Radar data is therefore the only way to access to the rainfall space-time organization, but the quality of the radar data may be highly variable as a function of (1) the relative locations of the event and the radar(s) and (2) the radar operating protocol(s) and maintenance. A positive point: heavy rainfall is associated with convection implying better visibility and lesser bright band contamination compared with more current situations. In parallel with the development of a regionalized and adaptive radar data processing system (TRADHy; Delrieu et al. 2009), a pragmatic approach is proposed here to make best use of the available radar and raingauge data for a given flash-flood event by: (1) Identifying and removing residual ground clutter, (2) Applying the "hydrologic visibility" concept (Pellarin et al. 2002) to correct for range-dependent errors (screening and VPR effects for non-attenuating wavelengths, (3) Estimating an effective Z-R relationship through a radar-raingauge optimization approach to remove the mean field bias (Dinku et al. 2002) A sensitivity study, based on the high-quality volume radar datasets collected during two intense rainfall events of the Bollène 2002 experiment (Delrieu et al. 2009), is first proposed. Then the method is implemented for two other historical events occurred in France (Avène 1997 and Aude 1999) with datasets of lesser quality. References: Delrieu, G., B. Boudevillain, J. Nicol, B. Chapon, P.-E. Kirstetter, H. Andrieu, and D. Faure, 2009: Bollène 2002 experiment: radar rainfall estimation in the Cévennes-Vivarais region, France. Journal of Applied Meteorology and Climatology, in press. Dinku, T., E.N. Anagnostou, and M. Borga, 2002: Improving Radar-Based Estimation of Rainfall over Complex Terrain. J. Appl. Meteor., 41, 1163-1178. Pellarin, T., G. Delrieu, G. M. Saulnier, H. Andrieu, B. Vignal, and J. D. Creutin, 2002: Hydrologic visibility of weather radar systems operating in mountainous regions: Case study for the Ardeche Catchment (France). Journal of Hydrometeorology, 3, 539-555.

Efficacy and Safety of Roflumilast in Korean Patients with COPD

PubMed Central

Lee, Jae Seung; Hong, Yoon Ki; Park, Tae Sun; Lee, Sei Won; Oh, Yeon-Mok

2016-01-01

Purpose Roflumilast is the only oral phosphodiesterase 4 inhibitor approved to treat chronic obstructive pulmonary disease (COPD) patients [post-bronchodilator forced expiratory volume in 1 second (FEV1) <50% predicted] with chronic bronchitis and a history of frequent exacerbations. This study evaluated the efficacy and safety of roflumilast in Korean patients with COPD and compared the efficacy based on the severity of airflow limitation. Materials and Methods A post-hoc subgroup analysis was performed in Korean COPD patients participating in JADE, a 12-week, double-blinded, placebo-controlled, parallel-group, phase III trial in Asia. The primary efficacy endpoint was the mean [least-squares mean adjusted for covariates (LSMean)] change in post-bronchodilator FEV1 from baseline to each post-randomization visit. Safety endpoints included adverse events (AEs) and changes in laboratory values, vital signs, and electrocardiograms. Results A total of 260 Korean COPD patients were recruited, of which 207 were randomized to roflumilast (n=102) or placebo (n=105) treatment. After 12 weeks, LSMean post-bronchodilator FEV1 increased by 43 mL for patients receiving roflumilast and decreased by 60 mL for those taking placebo. Adverse events were more common in the roflumilast group than in the placebo group; however, the types and frequency of AEs were comparable to those reported in previous studies. Conclusion Roflumilast significantly improved lung function with a tolerable safety profile in Korean COPD patients irrespective of the severity of airflow limitation. PMID:27189287

Modeling hydrologic and geomorphic hazards across post-fire landscapes using a self-organizing map approach

USGS Publications Warehouse

Friedel, Michael J.

2011-01-01

Few studies attempt to model the range of possible post-fire hydrologic and geomorphic hazards because of the sparseness of data and the coupled, nonlinear, spatial, and temporal relationships among landscape variables. In this study, a type of unsupervised artificial neural network, called a self-organized map (SOM), is trained using data from 540 burned basins in the western United States. The sparsely populated data set includes variables from independent numerical landscape categories (climate, land surface form, geologic texture, and post-fire condition), independent landscape classes (bedrock geology and state), and dependent initiation processes (runoff, landslide, and runoff and landslide combination) and responses (debris flows, floods, and no events). Pattern analysis of the SOM-based component planes is used to identify and interpret relations among the variables. Application of the Davies-Bouldin criteria following k-means clustering of the SOM neurons identified eight conceptual regional models for focusing future research and empirical model development. A split-sample validation on 60 independent basins (not included in the training) indicates that simultaneous predictions of initiation process and response types are at least 78% accurate. As climate shifts from wet to dry conditions, forecasts across the burned landscape reveal a decreasing trend in the total number of debris flow, flood, and runoff events with considerable variability among individual basins. These findings suggest the SOM may be useful in forecasting real-time post-fire hazards, and long-term post-recovery processes and effects of climate change scenarios.

Evaluation of Boundary Dam spillway using an Autonomous Sensor Fish Device

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deng, Z. D.; Duncan, J. P.; Arnold, J. L.

Fish passage conditions over spillways are important for the operations of hydroelectric dams because spillways are usually considered as a common alternative passage route to divert fish from the turbines. The objectives of this study were to determine the relative potential of fish injury during spillway passage both before and after the installation of baffle blocks at Boundary Dam, and to provide validation data for a model being used to predict total dissolved gas levels. Sensor Fish were deployed through a release system mounted on the face of the dam in the forebay. Three treatments, based on the lateral positionmore » on the spillway, were evaluated for both the baseline and post-modification evaluations: Left Middle, Right Middle, and Right. No significant acceleration events were detected in the forebay, gate, or transition regions for any release location; events were only observed on the chute and in the tailrace. Baseline acceleration events observed in the chute region were all classified as strikes, whereas post-modification events included strike and shear on the chute. While the addition of baffle blocks increased the number of significant events observed on the spillway chute, overall fewer events were observed in the tailrace post-modification. Analysis of lateral positioning of passage indicated that the Right Middle treatment was potentially less injurious to fish based on relative frequency of significant events at each location. The construction of baffle blocks on the spillway visibly changed the flow regime. Prior to installation the flow jet was relatively thin, impacting the tailrace as a coherent stream that plunged deeply, possibly contributing to total dissolved gas production. Following baffle block construction, the discharge jet was more fragmented, potentially disrupting the plunge depth and decreasing the time that bubbles would be at depth in the plunge pool. The results in this study support the expected performance of the modified spillway chute: the addition of the baffle blocks generally lessened the depth and impact of entry. This study provides information that can be used to help design and operate spillways for improving fish passage conditions.« less

An Immersive Virtual Reality Therapy Application for Iraq War Veterans with PTSD: From Training to Toy to Treatment

DTIC Science & Technology

2004-12-01

Post Traumatic Stress Disorder ( PTSD ) is reported to be caused by traumatic events that are outside the range of usual human...available X- Box game, Full Spectrum Warrior. 2. POST TRAUMATIC STRESS DISORDER According to the DSM-IV (1994), PTSD is caused by traumatic events...H. (2002). Virtual reality exposure therapy for World Trade Center Post Traumatic Stress Disorder . Cyberpsychology

Coping with stressful events: A pre-post-test of a psycho-educational intervention for undergraduate nursing and midwifery students.

PubMed

McCarthy, Bridie; Trace, Anna; O'Donovan, Moira; O'Regan, Patricia; Brady-Nevin, Caroline; O'Shea, Maria; Martin, Ann-Marie; Murphy, Margaret

2018-02-01

Knowledge of coping mechanisms is important for nursing and midwifery students to cope with stressful events during undergraduate education. To evaluate the impact of a psycho-educational intervention "Coping with Stressful Events" with first year undergraduate nursing and midwifery students. A quasi-experimental, one-group pre-post-test. One school of nursing/midwifery in one university in Ireland. A convenience sample of all first year undergraduate nursing and midwifery students (n=197). Of these 166 completed the pretest and 138 students completed the post test. Using the COPE Inventory questionnaire (Carver et al., 1989) data was collected pre and post-delivery of the psycho-educational intervention "Coping with Stressful Events" by two research assistants. Data were analysed using the IBM SPSS Statistics version 22 (NY, USA). Results demonstrated improved coping skills by students. There were statistically significant differences between pre and post intervention for some coping subscales. For example, the mean subscale scores were lower post-intervention for restraint and mental disengagement, and higher for use of emotional and instrumental social support indicating improved coping strategies. This intervention has the potential to influence undergraduate nursing and midwifery students coping skills during their first year of an undergraduate programme. Copyright © 2017 Elsevier Ltd. All rights reserved.

Event-related oscillations (EROs) and event-related potentials (ERPs) comparison in facial expression recognition.

PubMed

Balconi, Michela; Pozzoli, Uberto

2007-09-01

The study aims to explore the significance of event-related potentials (ERPs) and event-related brain oscillations (EROs) (delta, theta, alpha, beta, gamma power) in response to emotional (fear, happiness, sadness) when compared with neutral faces during 180-250 post-stimulus time interval. The ERP results demonstrated that the emotional face elicited a negative peak at approximately 230 ms (N2). Moreover, EEG measures showed that motivational significance of face (emotional vs. neutral) could modulate the amplitude of EROs, but only for some frequency bands (i.e. theta and gamma bands). In a second phase, we considered the resemblance of the two EEG measures by a regression analysis. It revealed that theta and gamma oscillations mainly effect as oscillation activity at the N2 latency. Finally, a posterior increased power of theta was found for emotional faces.

Social support and negative and positive outcomes of experienced traumatic events in a group of male emergency service workers.

PubMed

Ogińska-Bulik, Nina

2015-01-01

The paper investigates the relationship between perceived social support in the workplace and both negative (post-traumatic stress disorder (PTSD) symptoms) and positive outcomes (post-traumatic growth) of experienced traumatic events in a group of male emergency service workers. Data of 116 workers representing emergency services (37.1% firefighters, 37.1%, police officers and 30% medical rescue workers) who have experienced a traumatic event in their worksite were analyzed. The range of age of the participants was 21-57 years (M=35.27; SD=8.13). Polish versions of the Impact of Event Scale--Revised and the Post-traumatic Growth Inventory were used to assess the negative and positive outcomes of the experienced event. A perceived social support scale was measured by the scale What support you can count on. The data obtained from the study revealed the negative dependence of social support from supervisors with PTSD symptoms and positive--social support from co-workers with post-traumatic growth. Moreover the results of the study indicate the positive relationship between negative and positive outcomes of experienced traumatic events in the workplace. Perceived social support plays a more important role in gaining benefits from trauma than preventing negative outcomes of the experienced traumatic event. Support from co-workers, compared to support from supervisors, has greater importance.

Severe Autoimmune Adverse Events Post Herpes Zoster Vaccine: A Case-Control Study of Adverse Events in a National Database.

PubMed

Lai, Yi Chun; Yew, Yik Weng

2015-07-01

Zoster vaccine is recommended to reduce the incidence of herpes zoster and its complication of postherpetic neuralgia in older adults. However, there have been reports of autoimmune side effects post vaccination. We therefore aim to investigate the possible relationship of severe autoimmune adverse events (arthritis, vasculitis, systemic lupus erythematosus, thrombocytopenia, alopecia, Guillain-Barre syndrome, optic neuritis and multiple sclerosis) post zoster vaccination with a matched case-control study of reported events in the Vaccine Adverse Event Reporting System (VAERS). Our study showed no significantly increased risks of severe autoimmune adverse events, except arthritis and alopecia, after vaccination. Compared to the unexposed, patients with zoster vaccination had 2.2 and 2.7 times the odds of developing arthritis and alopecia, respectively (P<0.001 and P=0.015, respectively). However, almost none of these events was life threatening. Zoster vaccine is, therefore, relatively safe and unlikely to exacerbate or induce autoimmune diseases. Given its benefits and safety but low coverage, dermatologists and primary care physicians should encourage zoster vaccine use in elderly patients, including selected patients with autoimmune diseases.

Extreme gravity tests with gravitational waves from compact binary coalescences: (II) ringdown

NASA Astrophysics Data System (ADS)

Berti, Emanuele; Yagi, Kent; Yang, Huan; Yunes, Nicolás

2018-05-01

The LIGO/Virgo detections of binary black hole mergers marked a watershed moment in astronomy, ushering in the era of precision tests of Kerr dynamics. We review theoretical and experimental challenges that must be overcome to carry out black hole spectroscopy with present and future gravitational wave detectors. Among other topics, we discuss quasinormal mode excitation in binary mergers, astrophysical event rates, tests of black hole dynamics in modified theories of gravity, parameterized "post-Kerr" ringdown tests, exotic compact objects, and proposed data analysis methods to improve spectroscopic tests of Kerr dynamics by stacking multiple events.

Child disaster mental health interventions, part II

PubMed Central

Pfefferbaum, Betty; Sweeton, Jennifer L.; Newman, Elana; Varma, Vandana; Noffsinger, Mary A.; Shaw, Jon A.; Chrisman, Allan K.; Nitiéma, Pascal

2014-01-01

This review summarizes current knowledge on the timing of child disaster mental health intervention delivery, the settings for intervention delivery, the expertise of providers, and therapeutic approaches. Studies have been conducted on interventions delivered during all phases of disaster management from pre event through many months post event. Many interventions were administered in schools which offer access to large numbers of children. Providers included mental health professionals and school personnel. Studies described individual and group interventions, some with parent involvement. The next generation of interventions and studies should be based on an empirical analysis of a number of key areas. PMID:26295009

29 CFR 4043.35 - Bankruptcy or similar settlement.

Code of Federal Regulations, 2010 CFR

2010-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.35 Bankruptcy or similar settlement. (a) Reportable event. A reportable event occurs for a plan when... has actual knowledge of the reportable event. ...

29 CFR 4043.35 - Bankruptcy or similar settlement.

Code of Federal Regulations, 2011 CFR

2011-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.35 Bankruptcy or similar settlement. (a) Reportable event. A reportable event occurs for a plan when... has actual knowledge of the reportable event. ...

29 CFR 4043.35 - Bankruptcy or similar settlement.

Code of Federal Regulations, 2012 CFR

2012-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.35 Bankruptcy or similar settlement. (a) Reportable event. A reportable event occurs for a plan when... has actual knowledge of the reportable event. ...

29 CFR 4043.35 - Bankruptcy or similar settlement.

Code of Federal Regulations, 2013 CFR

2013-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.35 Bankruptcy or similar settlement. (a) Reportable event. A reportable event occurs for a plan when... has actual knowledge of the reportable event. ...

29 CFR 4043.35 - Bankruptcy or similar settlement.

Code of Federal Regulations, 2014 CFR

2014-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.35 Bankruptcy or similar settlement. (a) Reportable event. A reportable event occurs for a plan when... has actual knowledge of the reportable event. ...

Post-wildfire management

Treesearch

Jonathan W. Long; Carl Skinner; Susan Charnley; Ken Hubbert; Lenya Quinn-Davidson; Marc Meyer

2014-01-01

Wildfires, especially large, severe, and unmanageable events, exert major influences on socioecological systems, not only through risks to life and property, but also losses of important values associated with mature forest stands. These events prompt decisions about post-wildfire management interventions, including short-term emergency responses, salvage logging, and...

High-Resolution Data for a Low-Resolution World

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brady, Brendan Williams

2016-05-10

In the past 15 years, the upper section of Cañon de Valle has been severely altered by wildfires and subsequent runoff events. Loss of root structures on high-angle slopes results in debris flow and sediment accumulation in the narrow canyon bottom. The original intent of the study described here was to better understand the changes occurring in watershed soil elevations over the course of several post-fire years. An elevation dataset from 5 years post-Cerro Grande fire was compared to high-resolution LiDAR data from 14 years post-Cerro Grande fire (also 3 years post-Las Conchas fire). The following analysis was motivated bymore » a problematic comparison of these datasets of unlike resolution, and therefore focuses on what the data reveals of itself. The objective of this study is to highlight the effects vegetation can have on remote sensing data that intends to read ground surface elevation.« less

United States Geological Survey (USGS) Natural Hazards Response

USGS Publications Warehouse

Lamb, Rynn M.; Jones, Brenda K.

2012-01-01

The primary goal of U.S. Geological Survey (USGS) Natural Hazards Response is to ensure that the disaster response community has access to timely, accurate, and relevant geospatial products, imagery, and services during and after an emergency event. To accomplish this goal, products and services provided by the National Geospatial Program (NGP) and Land Remote Sensing (LRS) Program serve as a geospatial framework for mapping activities of the emergency response community. Post-event imagery and analysis can provide important and timely information about the extent and severity of an event. USGS Natural Hazards Response will also support the coordination of remotely sensed data acquisitions, image distribution, and authoritative geospatial information production as required for use in disaster preparedness, response, and recovery operations.

Experimental validation of finite element model analysis of a steel frame in simulated post-earthquake fire environments

NASA Astrophysics Data System (ADS)

Huang, Ying; Bevans, W. J.; Xiao, Hai; Zhou, Zhi; Chen, Genda

2012-04-01

During or after an earthquake event, building system often experiences large strains due to shaking effects as observed during recent earthquakes, causing permanent inelastic deformation. In addition to the inelastic deformation induced by the earthquake effect, the post-earthquake fires associated with short fuse of electrical systems and leakage of gas devices can further strain the already damaged structures during the earthquakes, potentially leading to a progressive collapse of buildings. Under these harsh environments, measurements on the involved building by various sensors could only provide limited structural health information. Finite element model analysis, on the other hand, if validated by predesigned experiments, can provide detail structural behavior information of the entire structures. In this paper, a temperature dependent nonlinear 3-D finite element model (FEM) of a one-story steel frame is set up by ABAQUS based on the cited material property of steel from EN 1993-1.2 and AISC manuals. The FEM is validated by testing the modeled steel frame in simulated post-earthquake environments. Comparisons between the FEM analysis and the experimental results show that the FEM predicts the structural behavior of the steel frame in post-earthquake fire conditions reasonably. With experimental validations, the FEM analysis of critical structures could be continuously predicted for structures in these harsh environments for a better assistant to fire fighters in their rescue efforts and save fire victims.

U.S. Army War College Key Strategic Issues List

DTIC Science & Technology

2008-07-01

post “operational or strategic event,” compare the pre-event modeled outcome to the post- event ground truth . Considering the elements of PMESII...Personnel Management, and Culture: 1. What is the future of telecommuting in the Army and its implications on performance and productivity? 2. On...requirements. VI. Underground Facilities as a National Security Challenge: 1. The construction and employment of Hard and Deeply Buried Targets (HDBTs

Post-Discharge Bleeding after Percutaneous Coronary Intervention and Subsequent Mortality and Myocardial Infarction: Insights from the HMO Research Network-Stent Registry

PubMed Central

Valle, Javier A.; Shetterly, Susan; Maddox, Thomas M.; Ho, P. Michael; Bradley, Steven M.; Sandhu, Amneet; Magid, David; Tsai, Thomas T.

2016-01-01

Background Bleeding following hospital discharge from percutaneous coronary intervention (PCI) is associated with increased risk of subsequent myocardial infarction (MI) and death, however the timing of adverse events following these bleeding events is poorly understood. Defining this relationship may help clinicians identify critical periods when patients are at highest risk. Methods and Results All patients undergoing PCI from 2004–2007 who survived to hospital discharge without a bleeding event were identified from the HMO Research Network-Stent Registry. Post-discharge rates and timing of bleeding-related hospitalizations, MI and death were defined. We then assessed the association between post-discharge bleeding-related hospitalizations with death and MI using Cox proportional hazards models. Among 8,137 post-PCI patients surviving to hospital discharge without in-hospital bleeding, 391 (4.8%) suffered bleeding-related hospitalization after discharge, with the highest incidence of bleeding-related hospitalizations occurring within 30 days of discharge (n=79, 20.2%). Post-discharge bleeding-related hospitalization after PCI was associated with subsequent death or MI (hazard ratio [HR] 3.09; 95% confidence interval [CI] 2.41–3.96), with the highest risk for death or MI occurring in the first 60 days after bleeding-related hospitalization (HR 7.16, CI 3.93–13.05). Conclusions Approximately 1 in 20 post-PCI patients are readmitted for bleeding, with the highest incidence occurring within 30 days of discharge. Patients suffering post-discharge bleeding are at increased risk for subsequent death or MI, with the highest risk occurring within the first 60 days following a bleeding-related hospitalization. These findings suggest a critical period after bleeding events when patients are most vulnerable for further adverse events. PMID:27301394

Post-rift Tectonic History of the Songliao Basin, NE China: Cooling Events and Post-rift Unconformities Driven by Orogenic Pulses From Plate Boundaries

NASA Astrophysics Data System (ADS)

Song, Ying; Stepashko, Andrei; Liu, Keyu; He, Qingkun; Shen, Chuanbo; Shi, Bingjie; Ren, Jianye

2018-03-01

The classic lithosphere-stretching model predicts that the post-rift evolution of extensional basin should be exclusively controlled by decaying thermal subsidence. However, the stratigraphy of the Songliao Basin in northeastern China shows that the post-rift evolution was punctuated by multiple episodes of uplift and exhumation events, commonly attributed to the response to regional tectonic events, including the far-field compression from plate margins. Three prominent tectonostratigraphic post-rift unconformities are recognized in the Late Cretaceous strata of the basin: T11, T03, and T02. The subsequent Cenozoic history is less constrained due to the incomplete record of younger deposits. In this paper, we utilize detrital apatite fission track (AFT) thermochronology to unravel the enigmatic timing and origin of post-rift unconformities. Relating the AFT results to the unconformities and other geological data, we conclude that in the post-rift stage, the basin experienced a multiepisodic tectonic evolution with four distinct cooling and exhumation events. The thermal history and age pattern document the timing of the unconformities in the Cretaceous succession: the T11 unconformity at 88-86 Ma, the T03 unconformity at 79-75 Ma, and the T02 unconformity at 65-50 Ma. A previously unrecognized Oligocene unconformity is also defined by a 32-24 Ma cooling event. Tectonically, all the cooling episodes were regional, controlled by plate boundary stresses. We propose that Pacific dynamics influenced the wider part of eastern Asia during the Late Cretaceous until Cenozoic, whereas the far-field effects of the Neo-Tethys subduction and collision processes became another tectonic driver in the later Cenozoic.

The Monitoring Erosion of Agricultural Land and spatial database of erosion events

NASA Astrophysics Data System (ADS)

Kapicka, Jiri; Zizala, Daniel

2013-04-01

In 2011 originated in The Czech Republic The Monitoring Erosion of Agricultural Land as joint project of State Land Office (SLO) and Research Institute for Soil and Water Conservation (RISWC). The aim of the project is collecting and record keeping information about erosion events on agricultural land and their evaluation. The main idea is a creation of a spatial database that will be source of data and information for evaluation and modeling erosion process, for proposal of preventive measures and measures to reduce negative impacts of erosion events. A subject of monitoring is the manifestations of water erosion, wind erosion and slope deformation in which cause damaged agriculture land. A website, available on http://me.vumop.cz, is used as a tool for keeping and browsing information about monitored events. SLO employees carry out record keeping. RISWC is specialist institute in the Monitoring Erosion of Agricultural Land that performs keeping the spatial database, running the website, managing the record keeping of events, analysis the cause of origins events and statistical evaluations of keeping events and proposed measures. Records are inserted into the database using the user interface of the website which has map server as a component. Website is based on database technology PostgreSQL with superstructure PostGIS and MapServer UMN. Each record is in the database spatial localized by a drawing and it contains description information about character of event (data, situation description etc.) then there are recorded information about land cover and about grown crops. A part of database is photodocumentation which is taken in field reconnaissance which is performed within two days after notify of event. Another part of database are information about precipitations from accessible precipitation gauges. Website allows to do simple spatial analysis as are area calculation, slope calculation, percentage representation of GAEC etc.. Database structure was designed on the base of needs analysis inputs to mathematical models. Mathematical models are used for detailed analysis of chosen erosion events which include soil analysis. Till the end 2012 has had the database 135 events. The content of database still accrues and gives rise to the extensive source of data that is usable for testing mathematical models.

The Impact of Post-Procedural Asymmetry, Expansion, and Eccentricity of Bioresorbable Everolimus-Eluting Scaffold and Metallic Everolimus-Eluting Stent on Clinical Outcomes in the ABSORB II Trial.

PubMed

Suwannasom, Pannipa; Sotomi, Yohei; Ishibashi, Yuki; Cavalcante, Rafael; Albuquerque, Felipe N; Macaya, Carlos; Ormiston, John A; Hill, Jonathan; Lang, Irene M; Egred, Mohaned; Fajadet, Jean; Lesiak, Maciej; Tijssen, Jan G; Wykrzykowska, Joanna J; de Winter, Robbert J; Chevalier, Bernard; Serruys, Patrick W; Onuma, Yoshinobu

2016-06-27

The study sought to investigate the relationship between post-procedural asymmetry, expansion, and eccentricity indices of metallic everolimus-eluting stent (EES) and bioresorbable vascular scaffold (BVS) and their respective impact on clinical events at 1-year follow-up. Mechanical properties of a fully BVS are inherently different from those of permanent metallic stent. The ABSORB II (A bioresorbable everolimus-eluting scaffold versus a metallic everolimus-eluting stent for ischaemic heart disease caused by de-novo native coronary artery lesions) trial compared the BVS and metallic EES in the treatment of a de novo coronary artery stenosis. Protocol-mandated intravascular ultrasound imaging was performed pre- and post-procedure in 470 patients (162 metallic EES and 308 BVS). Asymmetry index (AI) was calculated per lesion as: (1 - minimum scaffold/stent diameter/maximum scaffold/stent diameter). Expansion index and optimal scaffold/stent expansion followed the definition of the MUSIC (Multicenter Ultrasound Stenting in Coronaries) study. Eccentricity index (EI) was calculated as the ratio of minimum and maximum scaffold/stent diameter per cross section. The incidence of device-oriented composite endpoint (DoCE) was collected. Post-procedure, the metallic EES group was more symmetric and concentric than the BVS group. Only 8.0% of the BVS arm and 20.0% of the metallic EES arm achieved optimal scaffold/stent expansion (p < 0.001). At 1 year, there was no difference in the DoCE between both devices (BVS 5.2% vs. EES 3.1%; p = 0.29). Post-procedural devices asymmetry and eccentricity were related to higher event rates while there was no relevance to the expansion status. Subsequent multivariate analysis identified that post-procedural AI >0.30 is an independent predictor of DoCE (hazard ratio: 3.43; 95% confidence interval: 1.08 to 10.92; p = 0.037). BVS implantation is more frequently associated with post-procedural asymmetric and eccentric morphology compared to metallic EES. Post-procedural devices asymmetry were independently associated with DoCE following percutaneous coronary intervention. However, this approach should be viewed as hypothesis generating due to low event rates. (ABSORB II Randomized Controlled Trial [ABSORB II]; NCT01425281). Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

A Mixed-Method Analysis of Post-Trauma Outcomes: Trauma Severity and Social Support from a Psychotherapeutic Perspective

ERIC Educational Resources Information Center

Rieck, Murray; Shakespeare-Finch, Jane; Morris, Bronwyn; Newbery, Jasmin

2005-01-01

While research has focused on the difficulties faced in adapting to life following the experiences of a traumatic event, limited research has examined positive legacies of incorporating a traumatic experience into life posttrauma. This study uses quantitative and qualitative data (N = 218) to examine the effect that trauma severity and social…

Spatial Analysis of Post-Hurricane Katrina Thermal Pattern and Intensity in Greater New Orleans: Implications for Urban Heat Island Phenomenon

NASA Astrophysics Data System (ADS)

Lief, Aram Parrish

In 2005, Hurricane Katrina's diverse impacts on the Greater New Orleans area included damaged and destroyed trees, and other despoiled vegetation, which also increased the exposure of artificial and bare surfaces, known factors that contribute to the climatic phenomenon known as the urban heat island (UHI). This is an investigation of UHI in the aftermath of Hurricane Katrina, which entails the analysis of pre and post-hurricane Katrina thermal imagery of the study area, including changes to surface heat patterns and vegetative cover. Imagery from Landsat TM was used to show changes to the pattern and intensity of the UHI effect, caused by an extreme weather event. Using remote sensing visualization methods, in situ data, and local knowledge, the author found there was a measurable change in the pattern and intensity of the New Orleans UHI effect, as well as concomitant changes to vegetative land cover. This finding may be relevant for urban planners and citizens, especially in the context of recovery from a large-scale disaster of a coastal city, regarding future weather events, and other natural and human impacts.

A Power-Law Growth and Decay Model with Autocorrelation for Posting Data to Social Networking Services

PubMed Central

Fujiyama, Toshifumi; Matsui, Chihiro; Takemura, Akimichi

2016-01-01

We propose a power-law growth and decay model for posting data to social networking services before and after social events. We model the time series structure of deviations from the power-law growth and decay with a conditional Poisson autoregressive (AR) model. Online postings related to social events are described by five parameters in the power-law growth and decay model, each of which characterizes different aspects of interest in the event. We assess the validity of parameter estimates in terms of confidence intervals, and compare various submodels based on likelihoods and information criteria. PMID:27505155

Cumulative trauma and partner conflict predict post-traumatic stress disorder in postpartum African-American women.

PubMed

Hauff, Nancy J; Fry-McComish, Judith; Chiodo, Lisa M

2017-08-01

To describe relationships between cumulative trauma, partner conflict and post-traumatic stress in African-American postpartum women. Cumulative trauma exposure estimates for women in the USA range from 51-69%. During pregnancy, most trauma research has focused on physical injury to the mother. Post-traumatic stress disorder (PTSD) is associated with trauma and more prevalent in African-American women than women of other groups. Knowledge about both the rate and impact of cumulative trauma on pregnancy may contribute to our understanding of women seeking prenatal care, and disparities in infant morbidity and mortality. This retrospective, correlational, cross-sectional study took place on postpartum units of two Detroit hospitals. Participants were 150 African-American women aged between 18-45 who had given birth. Mothers completed the Cumulative Trauma Scale, Conflict Tactics Scale, Clinician Administered Post-traumatic Stress Scale, Edinburgh Postnatal Depression Scale and a Demographic Data form. Descriptive statistics, correlations and multiple regressions were used for data analysis. All participants reported at least one traumatic event in their lifetime. Cumulative trauma and partner conflict predicted PTSD, with the trauma of a life-threatening event for a loved one reported by 60% of the sample. Nearly, one-fourth of the women screened were at risk for PTSD. Increased cumulative trauma, increased partner conflict and lower level of education were related to higher rates of PTSD symptoms. Both cumulative trauma and partner conflict in the past year predict PTSD. Reasoning was used most often for partner conflict resolution. The results of this study offer additional knowledge regarding relationships between cumulative trauma, partner conflict and PTSD in African-American women. Healthcare providers need to be sensitive to patient life-threatening events, personal failures, abuse and other types of trauma. Current evidence supports the need to assess for post-traumatic stress symptoms during pregnancy. © 2016 John Wiley & Sons Ltd.

Safety of bronchoalveolar lavage in young children with cystic fibrosis.

PubMed

Wainwright, Claire E; Grimwood, Keith; Carlin, John B; Vidmar, Suzanna; Cooper, Peter J; Francis, Paul W; Byrnes, Catherine A; Whitehead, Bruce F; Martin, A James; Robertson, Ian F; Cooper, David M; Dakin, Carolyn J; Masters, Ian B; Massie, R John; Robinson, Philip J; Ranganathan, Sarath; Armstrong, David S; Patterson, Lyndall K; Robertson, Colin F

2008-10-01

Our aim was to determine the safety of BAL in young children <6 years with CF. As part of a multi-center study of BAL-directed therapy, children with CF < 6 years had one or more BALs between September 1999 and December 2005. Adverse events were recorded intraoperatively and for 24 hr thereafter. Clinical characteristics before BAL, findings at bronchoscopy and BAL results were assessed as risk factors for adverse events. 333 BALs were conducted in 107 (56 males) children, median age 23.5 (range 1.6-67.5) months, including 170 (51%) for pulmonary exacerbation. 29 BALs (8.7%) were followed by fever >or=38.5 degrees C and 10 (3%) had clinically significant episodes (five intraoperative hemoglobin desaturations to <90% requiring intervention, one tachyarrhythmia, two needing post-operative supplemental oxygen, one hospitalization for stridor). Two contaminated bronchoscopes were detected. 180 minor adverse events were recorded in 174 (52%) BAL procedures (137 altered cough, 41 fever <38.5 degrees C). Low percentage BAL return (P = 0.002) and focal bronchitis (P = 0.02) were associated with clinically significant deterioration. Multivariable analysis identified Streptococcus pneumoniae (OR 22.3; 95% confidence interval (CI); 6.9,72), Pseudomonas aeruginosa (OR 2.4; 95% CI 1.0, 5.8), respiratory signs (OR 5.0; 95% CI 1.7, 14.6) and focal bronchitis (OR 5.9; 95% CI 1.2, 29.8) as independent risk factors for post-bronchoscopy fever >or=38.5 degrees C. Adverse events are common with BAL in young CF children, but are usually transient and well tolerated. Parents should be counseled that signs of a pre-existing lower respiratory infection are associated with increased risk of post-BAL fever. (c) 2008 Wiley-Liss, Inc.

Content, Accessibility, and Dissemination of Disaster Information via Social Media During the 2016 Louisiana Floods.

PubMed

Scott, Katherine K; Errett, Nicole A

Social media is becoming increasingly integrated into disaster response communication strategies of public health and emergency response agencies. We sought to assess the content, accessibility, and dissemination of social media communications made by government agencies during a disaster response. A cross-sectional analysis of social media posts made by federal, state, and local government, public health and emergency management agencies before, during, and after the 2016 Louisiana floods was conducted to determine their content, accessibility, and dissemination by level of government and time relative to disaster onset. Facebook and/or Twitter posts made by public agencies involved in the response to the 2016 Louisiana Flooding events (FEMA Disaster Declaration [DR-4277]) published between August 4 and September 16, 2016, publicly available online between February 21 and March 31, 2017, were included in the analysis. Content: The text of each post was assessed to determine whether it contained information on provision of situational awareness; addressing misconception, actionable requests; mental, behavioral, and emotional support; and/or recovery and rebuilding resources. Accessibility: A Flesh-Kincaid grade level of each post was calculated, and information on post language, originality, hyperlinks, visuals, videos, or hash tag was recorded. Dissemination: The average number of reacts/likes, shares/retweets, and comments per post was calculated. Most posts contained information related to situational awareness and recovery resources. There was an increase in messages during the first week of the disaster at all levels. Few posts were made in languages other than English. Compared with state and federal posts, local Facebook posts averaged fewer reacts, comments, and shares throughout the analysis period. Government agencies may maximize the use of social media platforms for disaster communications by establishing their social media network in advance of a disaster and by applying established guidelines on disaster social media use.

[Systemic approach to radiobiological studies].

PubMed

Bulanova, K Ia; Lobanok, L M

2004-01-01

The principles of information theory were applied for analysis of radiobiological effects. The perception of ionizing radiations as a signal enables living organism to discern their benefits or harm, to react to absolute and relatively small deviations, to keep the logic and chronicle of events, to use the former experience for reacting in presence, to forecast consequences. The systemic analysis of organism's response to ionizing radiations allows explaining the peculiarities of effects of different absorbed doses, hormesis, apoptosis, remote consequences and other post-radiation effects.

A Pilot Health Information Technology-Based Effort to Increase the Quality of Transitions From Skilled Nursing Facility to Home: Compelling Evidence of High Rate of Adverse Outcomes.

PubMed

Donovan, Jennifer L; Kanaan, Abir O; Gurwitz, Jerry H; Tjia, Jennifer; Cutrona, Sarah L; Garber, Lawrence; Preusse, Peggy; Field, Terry S

2016-04-01

Older adults are often transferred from hospitals to skilled nursing facilities (SNFs) for post-acute care. Patients may be at risk for adverse outcomes after SNF discharges, but little research has focused on this period. Assessment of the feasibility of a transitional care intervention based on a combination of manual information transmission and health information technology to provide automated alert messages to primary care physicians and staff; pre-post analysis to assess potential impact. A multispecialty group practice. Adults aged 65 and older, discharged from SNFs to home; comparison group drawn from SNF discharges during the previous 1.5 years, matched on facility, patient age, and sex. For the pre-post analysis, we tracked rehospitalization within 30 days after discharge and adverse drug events within 45 days. The intervention was developed and implemented with manual transmission of information between 8 SNFs and the group practice followed by entry into the electronic health record. The process required a 5-day delay during which a large portion of the adverse events occurred. Over a 1-year period, automated alert messages were delivered to physicians and staff for the 313 eligible patients discharged from the 8 SNFs to home. We compared outcomes to those of individually matched discharges from the previous 1.5 years and found similar percentages with 30-day rehospitalizations (31% vs 30%, adjusted HR 1.06, 95% CI 0.80-1.4). Within the adverse drug event (ADE) study, 30% of the discharges during the intervention period and 30% of matched discharges had ADEs within 45 days. Older adults discharged from SNFs are at high risk of adverse outcomes immediately following discharge. Simply providing alerts to outpatient physicians, especially if delivered multiple days after discharge, is unlikely to have any impact on reducing these rates. Copyright © 2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.

Systematic Review of Treatment for Trapped Thrombus in Patent Foramen Ovale.

PubMed

Seo, Won-Woo; Kim, Sung Eun; Park, Myung-Soo; Lee, Jun-Hee; Park, Dae-Gyun; Han, Kyoo-Rok; Oh, Dong-Jin

2017-09-01

Trapped thrombus in patent foramen ovale (PFO) is a rare complication of pulmonary embolism that may lead to tragic clinical events. The aim of this study was to identify the optimal treatment for different clinical situations in patients with trapped thrombus in a PFO by conducting a literature review. A PubMed database search was conducted from 1991 through 2015, and 194 patients (185 articles) with trapped thrombus in a PFO were identified. Patient characteristics, paradoxical embolic events, and factors affecting 60-day mortality were analyzed retrospectively. Among all patients, 112 (57.7%) were treated with surgery, 28 with thrombolysis, and 54 with anticoagulation alone. Dyspnea (79.4%), chest pain (33.0%), and syncope (17.5%) were the most common presenting symptoms. Pretreatment embolism was found in 37.6% of cases, and stroke (24.7%) was the most common event. Surgery was associated with fewer post-treatment embolic events than were other treatment options (p=0.044). In the multivariate analysis, initial shock or arrest, and thrombolysis were independent predictors of 60-day mortality. Thrombolysis was related with higher 60-day mortality compared with surgery in patients who had no initial shock or arrest. This systematic review showed that surgery was associated with a lower overall incidence of post-treatment embolic events and a lower 60-day mortality in patients with trapped thrombus in a PFO. In patients without initial shock or arrest, thrombolysis was related with a higher 60-day mortality compared with surgery.

Impact of Deforestation and Recovery on Streamflow Recession Statistics

NASA Astrophysics Data System (ADS)

Krapu, C.; Kumar, M.

2016-12-01

Deforestation is known to influence streamflow and baseflow in particular in sub-humid environments. Baseflow contributions to the recession limb of a flood hydrograph convey information about subsurface stores from which trees also draw water. Recent works based on the assumptions outlined by Brutsaert and Nieber (1977) have proposed analyzing streamflow recession curves on a per-event basis. In this framework, each event's recession curve is governed by a power law relation with per-event scale and shape coefficients. As streamflow recession depends in part upon evapotranspiration demand from trees, these coefficients are hypothesized to contain useful information about catchment vegetation. Analysis was conducted of 13 small experimental catchments in the eastern United States with known forest treatment histories to determine whether or not streamflow recession behavior as observed from daily discharge records could serve as an indicator of deforestation in the drainage basin. Power-law scale coefficients were calculated for each major stormflow event at each test site and a statistical comparison of distribution of fitted coefficients was made between pre-treatment and post-treatment events as well as between pre-treatment and post-recovery events. A second method using these fitted coefficients in conjunction with Gaussian process regression was employed to track the change in the scale coefficient in the 13 catchments described previously as well as two medium-sized catchments in the North Carolina portion of the American Piedmont which did not have extensive records of forest cover. A linear trend analysis of precipitation was performed to determine whether nonstationarity in rainfall could be a confounding cause of changes in event scale coefficients. These results show a statistically significant difference in scale coefficient values in 5/8 treatment catchments and 0/5 control catchments. This suggests that lesser alterations to forest cover may not be detectable but that this method is robust against changes in precipitation. Additionally, we found clear evidence that forest regrowth in the Piedmont sites continued from 1940-1970. As a proof-of-concept, this work suggests that major alterations to forest cover can be inferred from daily data of stream discharge.

Partial and no recovery from delirium after hospital discharge predict increased adverse events.

PubMed

Cole, Martin G; McCusker, Jane; Bailey, Robert; Bonnycastle, Michael; Fung, Shek; Ciampi, Antonio; Belzile, Eric

2017-01-08

The implications of partial and no recovery from delirium after hospital discharge are not clear. We sought to explore whether partial and no recovery from delirium among recently discharged patients predicted increased adverse events (emergency room visits, hospitalisations, death) during the subsequent 3 months. Prospective study of recovery from delirium in older hospital inpatients. The Confusion Assessment Method was used to diagnose delirium in hospital and determine recovery status after discharge (T0). Adverse events were determined during the 3 months T0. Survival analysis to the first adverse event and counting process modelling for one or more adverse events were used to examine associations between recovery status (ordinal variable, 0, 1 or 2 for full, partial or no recovery, respectively) and adverse events. Of 278 hospital inpatients with delirium, 172 were discharged before the assessment of recovery status (T0). Delirium recovery status at T0 was determined for 152: 25 had full recovery, 32 had partial recovery and 95 had no recovery. Forty-four patients had at least one adverse event during the subsequent 3 months. In multivariable analysis of one or more adverse events, poorer recovery status predicted increased adverse events; the hazard ratio (HR) (95% confidence interval, CI) was 1.72 (1.09, 2.71). The association of recovery status with adverse events was stronger among patients without dementia. Partial and no recovery from delirium after hospital discharge appear to predict increased adverse events during the subsequent 3 months These findings have potentially important implications for in-hospital and post-discharge management and policy.

Towards a post-traumatic subtype of obsessive-compulsive disorder.

PubMed

Fontenelle, Leonardo F; Cocchi, Luca; Harrison, Ben J; Shavitt, Roseli G; do Rosário, Maria Conceição; Ferrão, Ygor A; de Mathis, Maria Alice; Cordioli, Aristides V; Yücel, Murat; Pantelis, Christos; Mari, Jair de Jesus; Miguel, Euripedes C; Torres, Albina R

2012-03-01

We evaluated whether traumatic events are associated with a distinctive pattern of socio-demographic and clinical features of obsessive-compulsive disorder (OCD). We compared socio-demographic and clinical features of 106 patients developing OCD after post-traumatic stress disorder (PTSD; termed post-traumatic OCD), 41 patients developing OCD before PTSD (pre-traumatic OCD), and 810 OCD patients without any history of PTSD (non-traumatic OCD) using multinomial logistic regression analysis. A later age at onset of OCD, self-mutilation disorder, history of suicide plans, panic disorder with agoraphobia, and compulsive buying disorder were independently related to post-traumatic OCD. In contrast, earlier age at OCD onset, alcohol-related disorders, contamination-washing symptoms, and self-mutilation disorder were all independently associated with pre-traumatic OCD. In addition, patients with post-traumatic OCD without a previous history of obsessive-compulsive symptoms (OCS) showed lower educational levels, greater rates of contamination-washing symptoms, and more severe miscellaneous symptoms as compared to post-traumatic OCD patients with a history of OCS. Copyright © 2011 Elsevier Ltd. All rights reserved.

76 FR 64351 - Agency Forms Undergoing Paperwork Reduction Act Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-18

... of the proposed study is two- fold: (1) To examine healthcare facility compliance with the New Jersey... events, violence prevention committee, written violence prevention plan, violence risk assessments, post... facility violent event reports 3 years pre-regulation (2009-2011) and 3 years post-regulation (2012-2014...

Rapid Offline-Online Post-Disaster Landslide Mapping Tool: A case study from Nepal

NASA Astrophysics Data System (ADS)

Olyazadeh, Roya; Jaboyedoff, Michel; Sudmeier-Rieux, Karen; Derron, Marc-Henri; Devkota, Sanjaya

2016-04-01

One of the crucial components of post disaster management is the efficient mapping of impacted areas. Here we present a tool designed to map landslides and affected objects after the earthquakes of 2015 in Nepal as well as for intense rainfall impact. Because internet is not available in many rural areas of Nepal, we developed an offline-online prototype based on Open-Source WebGIS technologies to make data on hazard impacts, including damaged infrastructure, landslides or flooding events available to authorities and the general public. This mobile application was designed as a low-cost, rapid and participatory method for recording impacts from hazard events. It is possible to record such events offline and upload them through a server, where internet connection is available. This application allows user authentication, image capturing, and information collation such as geolocation, event description, interactive mapping and finally storing all the data in the server for further analysis and visualisation. This application can be accessed by a mobile phone (Android) or a tablet as a hybrid version for both offline and online versions. The offline version has an interactive-offline map function which allows users to upload satellites image in order to improve ground truthing interpretation. After geolocation, the user can start mapping and then save recorded data into Geojson-TXT files that can be easily uploaded to the server whenever internet is available. This prototype was tested specifically for a rapid assessment of landslides and relevant land use characteristics such as roads, forest area, rivers in the Phewa Lake watershed near Pokhara, Nepal where a large number landslides were activated or reactivated after the 2015 monsoon season. More than 60 landslides were recorded during two days of field trip. Besides, it is possible to use this application for any other kind of hazard event like flood, avalanche, etc. Keywords: Offline, Online, Open source, WebGIS, Android, Post-Disaster, Landslide mapping

Post-trauma coping in the context of significant adversity: a qualitative study of young people living in an urban township in South Africa

PubMed Central

Hiller, Rachel M; Tomlinson, Mark; Stewart, Jackie; Skeen, Sarah; Christie, Hope

2017-01-01

Objective Compared with knowledge of the post-trauma needs of young people living in developed countries, little is known about the needs of those in low-middle-income countries. Such information is crucial, particularly as young people in these environments can be at increased risk of experiencing trauma, coupled with less available resources for formal support. The aim of this study was to explore post-trauma coping and support-seeking of young people living in a high-adversity settlement in South Africa. Design Semistructured qualitative interviews analysed using thematic analysis. Setting An urban settlement (‘township’) in Cape Town, South Africa. Participants 25 young people, aged 13–17 years, who had experienced trauma. Events included serious car accidents, hearing of a friend’s violent death, and rape, and all reported having experienced multiple traumatic events. All participants identified as black South African and spoke Xhosa as their first language. Results Social support was considered key to coping after trauma, although the focus of the support differed depending on the source. Parents would most commonly provide practical support, particularly around safety. Peers often provided an avenue to discuss the event and young person’s emotional well-being more openly. Outside of social support another key theme was that there were numerous community-level barriers to participants receiving support following trauma. Many young people continued to be exposed to the perpetrator of the event, while there was also the realistic concern around future traumas and safety, community stigma and a perceived lack of justice. Conclusion This study provides insight into how young people cope and seek support following trauma when they are living in a context of significant adversity and risk. Overall, most young people identified helpful sources of support and thought talking about the event was a useful strategy, but concerns around safety and trust could impede this process. PMID:28988171

Planform changes and large wood dynamics in two torrents during a severe flash flood in Braunsbach, Germany 2016.

PubMed

Lucía, Ana; Schwientek, Marc; Eberle, Joachim; Zarfl, Christiane

2018-05-30

This work presents a post-event survey study, addressing the geomorphic response and large wood budget of two torrents, Grimmbach and Orlacher Bach, in southwestern Germany that were affected by a flash flood on May 29, 2016. During the event, large amounts of wood clogged and damaged a bridge of a cycling path at the outlet of the Grimmbach, while the town of Braunsbach was devastated by discharge and material transported along the Orlacher Bach. The severity of the event in these two small catchments (30.0 km 2 and 5.95 km 2 , respectively) is remarkable in basins with a relatively low average slope (10.7 and 12.0%, respectively). In order to gain a better understanding of the driving forces during this flood event an integrated approach was applied including (i) an estimate of peak discharges, (ii) an analysis of changes in channel width by comparing available aerial photographs before the flood with a post-flood aerial surveys with an Unmanned Aerial Vehicle and validation with field observations, (iii) a detailed mapping of landslides and analysis of their connectivity with the channel network and finally (iv) an analysis of the amounts of large wood recruited and deposited in the channel. The morphological changes in the channels can be explained by hydraulic parameters, such as stream power and unit stream power, and by morphological parameters such as the valley confinement. This is similar for LW recruitment amounts and volume of exported LW since most of it comes from the erosion of the valley floor. The morphological changes and large wood recruitment and deposit are in the range of studied mountain rivers. Both factors thus need to be considered for mapping and mitigating flash flood hazards also in this kind of low range mountains. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

Externalising the autobiographical self: sharing personal memories online facilitated memory retention.

PubMed

Wang, Qi; Lee, Dasom; Hou, Yubo

2017-07-01

Internet technology provides a new means of recalling and sharing personal memories in the digital age. What is the mnemonic consequence of posting personal memories online? Theories of transactive memory and autobiographical memory would make contrasting predictions. In the present study, college students completed a daily diary for a week, listing at the end of each day all the events that happened to them on that day. They also reported whether they posted any of the events online. Participants received a surprise memory test after the completion of the diary recording and then another test a week later. At both tests, events posted online were significantly more likely than those not posted online to be recalled. It appears that sharing memories online may provide unique opportunities for rehearsal and meaning-making that facilitate memory retention.

The costs and benefits of reconstruction options in Nepal using the CEDIM FDA modelled and empirical analysis following the 2015 earthquake

NASA Astrophysics Data System (ADS)

Daniell, James; Schaefer, Andreas; Wenzel, Friedemann; Khazai, Bijan; Girard, Trevor; Kunz-Plapp, Tina; Kunz, Michael; Muehr, Bernhard

2016-04-01

Over the days following the 2015 Nepal earthquake, rapid loss estimates of deaths and the economic loss and reconstruction cost were undertaken by our research group in conjunction with the World Bank. This modelling relied on historic losses from other Nepal earthquakes as well as detailed socioeconomic data and earthquake loss information via CATDAT. The modelled results were very close to the final death toll and reconstruction cost for the 2015 earthquake of around 9000 deaths and a direct building loss of ca. 3 billion (a). A description of the process undertaken to produce these loss estimates is described and the potential for use in analysing reconstruction costs from future Nepal earthquakes in rapid time post-event. The reconstruction cost and death toll model is then used as the base model for the examination of the effect of spending money on earthquake retrofitting of buildings versus complete reconstruction of buildings. This is undertaken future events using empirical statistics from past events along with further analytical modelling. The effects of investment vs. the time of a future event is also explored. Preliminary low-cost options (b) along the line of other country studies for retrofitting (ca. 100) are examined versus the option of different building typologies in Nepal as well as investment in various sectors of construction. The effect of public vs. private capital expenditure post-earthquake is also explored as part of this analysis, as well as spending on other components outside of earthquakes. a) http://www.scientificamerican.com/article/experts-calculate-new-loss-predictions-for-nepal-quake/ b) http://www.aees.org.au/wp-content/uploads/2015/06/23-Daniell.pdf

Cost-effectiveness analysis of applying the Cholesterol and Recurrent Events (CARE) study protocol in Hong Kong.

PubMed

Chau, J; Cheung, B M; McGhee, S M; Lauder, I J; Lau, C P; Kumana, C R

2001-12-01

To determine the cost-effectiveness of secondary prevention with pravastatin in Hong Kong patients with coronary heart disease and average cholesterol levels. Cost-effectiveness analysis based on published results of the CARE study. Men and women post-myocardial infarction with average cholesterol levels. Cost-effectiveness analysis: cost per life saved, cost per fatal or non-fatal coronary event prevented, cost per procedure prevented, and cost per fatal or non-fatal stroke prevented. Cost-utility analysis: gross cost and net cost per quality-adjusted life year gained calculated using two alternative models. Cost per life saved or death prevented was HK$4,442,350 (non-discounted); cost per fatal or non-fatal cardiac event prevented HK$1,146,413; cost per procedure prevented HK$732,759; and cost per fatal or non-fatal stroke prevented HK$2,961,566. Net cost per quality adjusted life year gained was HK$73,218 and HK$65,280 non-discounted, respectively using the two alternative models. The results of this study can assist in prioritising the use of health care resources in Hong Kong but should be considered alongside the benefits and costs of alternative interventions for coronary heart disease.

Methodological issues in assessing changes in costs pre- and post-medication switch: a schizophrenia study example.

PubMed

Faries, Douglas E; Nyhuis, Allen W; Ascher-Svanum, Haya

2009-05-27

Schizophrenia is a severe, chronic, and costly illness that adversely impacts patients' lives and health care payer budgets. Cost comparisons of treatment regimens are, therefore, important to health care payers and researchers. Pre-Post analyses ("mirror-image"), where outcomes prior to a medication switch are compared to outcomes post-switch, are commonly used in such research. However, medication changes often occur during a costly crisis event. Patients may relapse, be hospitalized, have a medication change, and then spend a period of time with intense use of costly resources (post-medication switch). While many advantages and disadvantages of Pre-Post methodology have been discussed, issues regarding the attributability of costs incurred around the time of medication switching have not been fully investigated. Medical resource use data, including medications and acute-care services (hospitalizations, partial hospitalizations, emergency department) were collected for patients with schizophrenia who switched antipsychotics (n = 105) during a 1-year randomized, naturalistic, antipsychotic cost-effectiveness schizophrenia trial. Within-patient changes in total costs per day were computed during the pre- and post-medication change periods. In addition to the standard Pre-Post analysis comparing costs pre- and post-medication change, we investigated the sensitivity of results to varying assumptions regarding the attributability of acute care service costs occurring just after a medication switch that were likely due to initial medication failure. Fifty-six percent of all costs incurred during the first week on the newly initiated antipsychotic were likely due to treatment failure with the previous antipsychotic. Standard analyses suggested an average increase in cost-per-day for each patient of $2.40 after switching medications. However, sensitivity analyses removing costs incurred post-switch that were potentially due to the failure of the initial medication suggested decreases in costs in the range of $4.77 to $9.69 per day post-switch. Pre-Post cost analyses are sensitive to the approach used to handle acute-service costs occurring just after a medication change. Given the importance of quality economic research on the cost of switching treatments, thorough sensitivity analyses should be performed to identify the impact of crisis events around the time of medication change.

Application of Natural Language Processing and Network Analysis Techniques to Post-market Reports for the Evaluation of Dose-related Anti-Thymocyte Globulin Safety Patterns.

PubMed

Botsis, Taxiarchis; Foster, Matthew; Arya, Nina; Kreimeyer, Kory; Pandey, Abhishek; Arya, Deepa

2017-04-26

To evaluate the feasibility of automated dose and adverse event information retrieval in supporting the identification of safety patterns. We extracted all rabbit Anti-Thymocyte Globulin (rATG) reports submitted to the United States Food and Drug Administration Adverse Event Reporting System (FAERS) from the product's initial licensure in April 16, 1984 through February 8, 2016. We processed the narratives using the Medication Extraction (MedEx) and the Event-based Text-mining of Health Electronic Records (ETHER) systems and retrieved the appropriate medication, clinical, and temporal information. When necessary, the extracted information was manually curated. This process resulted in a high quality dataset that was analyzed with the Pattern-based and Advanced Network Analyzer for Clinical Evaluation and Assessment (PANACEA) to explore the association of rATG dosing with post-transplant lymphoproliferative disorder (PTLD). Although manual curation was necessary to improve the data quality, MedEx and ETHER supported the extraction of the appropriate information. We created a final dataset of 1,380 cases with complete information for rATG dosing and date of administration. Analysis in PANACEA found that PTLD was associated with cumulative doses of rATG >8 mg/kg, even in periods where most of the submissions to FAERS reported low doses of rATG. We demonstrated the feasibility of investigating a dose-related safety pattern for a particular product in FAERS using a set of automated tools.

Debriefing of the medical team after emergencies on cruise ships.

PubMed

Dahl, Eilif

2017-01-01

Done to improve safety and patient outcome but not to lay blame, debriefings on cruise ships should preferably be conducted as standard practice in the medical facility immediately after all critical events aboard. The key questions to be asked are: What went well, what could have gone better and what must participants do to improve care? Post-debriefing the ship's doctor might have to deal with team members' mental stress resulting both from the event and from debriefing it. Required by most cruise companies, standardised advanced life support courses teach effective high-performance team dynamics. They provide the multinational medical staff with a clearer understanding of the rescue sequence, which again will reduce the risk of mistakes and simplify post-event debriefings. Their systematic approach to the chain of survival is also helpful for post-event debriefings if something went wrong.

The presence of academic health sciences libraries on Facebook: the relationship between content and library popularity.

PubMed

Garcia-Milian, Rolando; Norton, Hannah F; Tennant, Michele R

2012-01-01

Social networks such as Facebook allow libraries to be proactive in reaching their users. While some libraries have popular Facebook pages, it remains unclear what attracts users to these pages. This study evaluates relationships between libraries' Facebook page content and popularity. An analysis of 72 academic health sciences libraries' Facebook pages showed positive correlations between number of library fans and number of tabs, photos, events, and wall posts on Facebook. Libraries posting videos had significantly more fans than libraries without them. This study contributes to an understanding of correlations between content and popularity on Facebook, with implications for library outreach.

29 CFR 4043.22 - Amendment decreasing benefits payable.

Code of Federal Regulations, 2010 CFR

2010-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.22 Amendment decreasing benefits payable. (a) Reportable event. A reportable event occurs... contributions with respect to any participant may be decreased. (b) Waivers. Notice is waived for this event. ...

29 CFR 4043.21 - Tax disqualification and title I noncompliance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.21 Tax disqualification and title I noncompliance. (a) Reportable event. A reportable event... with title I of ERISA. (b) Waivers. Notice is waived for this event. ...

29 CFR 4043.22 - Amendment decreasing benefits payable.

Code of Federal Regulations, 2014 CFR

2014-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.22 Amendment decreasing benefits payable. (a) Reportable event. A reportable event occurs... contributions with respect to any participant may be decreased. (b) Waivers. Notice is waived for this event. ...

29 CFR 4043.21 - Tax disqualification and title I noncompliance.

Code of Federal Regulations, 2014 CFR

2014-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.21 Tax disqualification and title I noncompliance. (a) Reportable event. A reportable event... with title I of ERISA. (b) Waivers. Notice is waived for this event. ...

29 CFR 4043.31 - Extraordinary dividend or stock redemption.

Code of Federal Regulations, 2014 CFR

2014-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.31 Extraordinary dividend or stock redemption. (a) Reportable event. A reportable event...) Extraordinary dividends and stock redemptions. The reportable event described in section 4043(c)(11) of ERISA...

29 CFR 4043.22 - Amendment decreasing benefits payable.

Code of Federal Regulations, 2012 CFR

2012-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.22 Amendment decreasing benefits payable. (a) Reportable event. A reportable event occurs... contributions with respect to any participant may be decreased. (b) Waivers. Notice is waived for this event. ...

29 CFR 4043.21 - Tax disqualification and title I noncompliance.

Code of Federal Regulations, 2012 CFR

2012-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.21 Tax disqualification and title I noncompliance. (a) Reportable event. A reportable event... with title I of ERISA. (b) Waivers. Notice is waived for this event. ...

29 CFR 4043.21 - Tax disqualification and title I noncompliance.

Code of Federal Regulations, 2011 CFR

2011-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.21 Tax disqualification and title I noncompliance. (a) Reportable event. A reportable event... with title I of ERISA. (b) Waivers. Notice is waived for this event. ...

29 CFR 4043.21 - Tax disqualification and title I noncompliance.

Code of Federal Regulations, 2013 CFR

2013-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.21 Tax disqualification and title I noncompliance. (a) Reportable event. A reportable event... with title I of ERISA. (b) Waivers. Notice is waived for this event. ...

29 CFR 4043.22 - Amendment decreasing benefits payable.

Code of Federal Regulations, 2013 CFR

2013-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.22 Amendment decreasing benefits payable. (a) Reportable event. A reportable event occurs... contributions with respect to any participant may be decreased. (b) Waivers. Notice is waived for this event. ...

29 CFR 4043.22 - Amendment decreasing benefits payable.

Code of Federal Regulations, 2011 CFR

2011-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.22 Amendment decreasing benefits payable. (a) Reportable event. A reportable event occurs... contributions with respect to any participant may be decreased. (b) Waivers. Notice is waived for this event. ...

Key landscape and biotic indicators of watersheds sensitivity to forest disturbance identified using remote sensing and historical hydrography data

NASA Astrophysics Data System (ADS)

Buma, Brian; Livneh, Ben

2017-07-01

Water is one of the most critical resources derived from natural systems. While it has long been recognized that forest disturbances like fire influence watershed streamflow characteristics, individual studies have reported conflicting results with some showing streamflow increases post-disturbance and others decreases, while other watersheds are insensitive to even large disturbance events. Characterizing the differences between sensitive (e.g. where streamflow does change post-disturbance) and insensitive watersheds is crucial to anticipating response to future disturbance events. Here, we report on an analysis of a national-scale, gaged watershed database together with high-resolution forest mortality imagery. A simple watershed response model was developed based on the runoff ratio for watersheds (n = 73) prior to a major disturbance, detrended for variation in precipitation inputs. Post-disturbance deviations from the expected water yield and streamflow timing from expected (based on observed precipitation) were then analyzed relative to the abiotic and biotic characteristics of the individual watershed and observed extent of forest mortality. The extent of the disturbance was significantly related to change in post-disturbance water yield (p < 0.05), and there were several distinctive differences between watersheds exhibiting post-disturbance increases, decreases, and those showing no change in water yield. Highly disturbed, arid watersheds with low soil: water contact time are the most likely to see increases, with the magnitude positively correlated with the extent of disturbance. Watersheds dominated by deciduous forest with low bulk density soils typically show reduced yield post-disturbance. Post-disturbance streamflow timing change was associated with climate, forest type, and soil. Snowy coniferous watersheds were generally insensitive to disturbance, whereas finely textured soils with rapid runoff were sensitive. This is the first national scale investigation of streamflow post-disturbance using fused gage and remotely sensed data at high resolution, and gives important insights that can be used to anticipate changes in streamflow resulting from future disturbances.

The Braunsbach Flashflood of May 29, 2016: A forensic analysis of the meteorological origin and the hydrological development an extreme hydro-meteorological event

NASA Astrophysics Data System (ADS)

Bronstert, Axel; Ankit, Agarwal; Berry, Boessenkool; Madlen, Fischer; Maik, Heistermann; Lisei, Köhn-Reich; Thomas, Moran; Dadiyorto, Wendi

2017-04-01

The flash-flood at 29th May 2016 in the vicinity of the village of Braunsbach in Southwestern Germany, State of Baden-Wuerttemberg, has been a particularly concise event of the floods occurring in southern Germany at the end of May / early June 2016. This extreme event was triggered by a convective high intensity rain storm, causing extreme discharge rates and subsequent debris flow in the local creek. This led to severe flooding of the village with immense damages. Besides its extreme nature, the event is characterized by very local and short term scales, i.e. the catchment of the creek covers an area of only six km2 and the whole event lasted only two hours. This contribution presents a retrospective analysis with regard to meteorology and hydrology to obtain a quantitative assessment of the governing processes and their development. We term this a "forensic analysis" because due to the very local and sudden feature of this flashflood event, the processes cannot be directly measured during the event and/or at the site. Instead, they need to be reconstructed and estimated after the event from a variety of rather different information sources and "soft" data. Using these types of post event observations and analysis, we aim at obtaining a rather comprehensive picture of the event and its consequences. Regarding rainfall, both station data from the surroundings of the catchment and radar data from the German Weather Service were analyzed, including the analysis of different errors types and dynamic features of the convective system. The flood hydrograph, including the maximum discharge rate during the event, was estimated by three different approaches, which were compared to obtain an idea of the associated uncertainty. The overall results of this forensic analysis show that it was a very rare rainfall event with extreme rainfall intensities, e.g. return period exceeding 100 years. Catalyzed by catchment properties, this lead to extreme runoff, severe soil erosion, and subsequent debris flow processes. Due to the complex and interacting processes, the hazard must not be attributed to a single cause, since only the interplay of the different processes and catchment conditions can lead to such an event. The people in the region say that such an event "has never happened before". However, from some first geomorphological analysis we got some indications that such events, including debris flow, might have happened before during previous times (time scale of millennia). Therefore, it would be more appropriate to state that "nobody can remember of such an event".

Clinical Assessment of Tribulus terrestris Extract in the Treatment of Female Sexual Dysfunction

PubMed Central

Gama, Carlos RB; Lasmar, Ricardo; Gama, Gustavo F; Abreu, Camila S; Nunes, Carlos P; Geller, Mauro; Oliveira, Lisa; Santos, Alessandra

2014-01-01

This is a qualitative–quantitative study based on hospital records of female patients of reproductive age, presenting sexual dysfunction, and treated with 250 mg Tribulus terrestris extract (1 tablet thrice daily for 90 days). Safety monitoring included vital signs, physical examination, laboratory tests, and occurrence of adverse events. Efficacy analysis included results of the Female Sexual Function Index (FSFI), dehydroepiandrosterone (DHEA) levels together with total and free testosterone, and the patient and physician assessments. There was a statistically significant improvement in total FSFI scores (P < 0.0001) post-treatment, with improvement among 106 (88.33%) subjects. There was a statistically significant (P < 0.0001) increase in the level of DHEA, while the levels of both serum testosterone (P = 0.284) and free testosterone decreased (P < 0.0001). Most adverse events recorded were related to the gastrointestinal tract. Physical examination showed no significant changes post-treatment. Based on the results, it is concluded that the T. terrestris extract is safe and effective in the treatment of female sexual dysfunction. PMID:25574150

Clinical Assessment of Tribulus terrestris Extract in the Treatment of Female Sexual Dysfunction.

PubMed

Gama, Carlos Rb; Lasmar, Ricardo; Gama, Gustavo F; Abreu, Camila S; Nunes, Carlos P; Geller, Mauro; Oliveira, Lisa; Santos, Alessandra

2014-01-01

This is a qualitative-quantitative study based on hospital records of female patients of reproductive age, presenting sexual dysfunction, and treated with 250 mg Tribulus terrestris extract (1 tablet thrice daily for 90 days). Safety monitoring included vital signs, physical examination, laboratory tests, and occurrence of adverse events. Efficacy analysis included results of the Female Sexual Function Index (FSFI), dehydroepiandrosterone (DHEA) levels together with total and free testosterone, and the patient and physician assessments. There was a statistically significant improvement in total FSFI scores (P < 0.0001) post-treatment, with improvement among 106 (88.33%) subjects. There was a statistically significant (P < 0.0001) increase in the level of DHEA, while the levels of both serum testosterone (P = 0.284) and free testosterone decreased (P < 0.0001). Most adverse events recorded were related to the gastrointestinal tract. Physical examination showed no significant changes post-treatment. Based on the results, it is concluded that the T. terrestris extract is safe and effective in the treatment of female sexual dysfunction.

Analysis of the mdr-1 Gene in Patients Co-Infected with Onchocerca volvulus and Loa loa Who Experienced a Post-Ivermectin Serious Adverse Event

PubMed Central

Bourguinat, Catherine; Kamgno, Joseph; Boussinesq, Michel; Mackenzie, Charles D.; Prichard, Roger K.; Geary, Timothy G.

2010-01-01

Ivermectin (IVM) is exceptionally safe in humans, and is used for mass treatment of onchocerciasis and lymphatic filariasis. However, cases of encephalopathy, sometimes fatal, have been reported in a small number of individuals who harbored large numbers of Loa loa microfilariae (mf). A loss-of-function mutation in the mdr-1 gene in some dog breeds and in mice leads to accumulation of the drug in the brain, causing coma and death. This hypothesis was tested in four individuals from Cameroon who experienced a post-IVM serious adverse event (SAE) and in nine non-SAE matched controls. No loss-of-function mutation was detected in mdr-1 in any subject. However, haplotypes, associated with altered drug disposition, were present as homozygotes in two of the SAE patients (50%), but absent as homozygotes in the controls (0%). An association of high Loa mf load and a genetic predisposition to altered IVM distribution could be involved in IVM SAEs. PMID:20595473

Post hoc analyses: after the facts.

PubMed

Srinivas, Titte R; Ho, Bing; Kang, Joseph; Kaplan, Bruce

2015-01-01

Prospective clinical trials are constructed with high levels of internal validity. Sample size and power considerations usually address primary endpoints. Primary endpoints have traditionally included events that are becoming increasingly less common and thus have led to growing use of composite endpoints and noninferiority trial designs in transplantation. This approach may mask real clinical benefit in one or the other domain with regard to either clinically relevant secondary endpoints or other unexpected findings. In addition, endpoints solely chosen based on power considerations are prone to misjudgment of actual treatment effect size as well as consistency of that effect. In the instances where treatment effects may have been underestimated, valuable information may be lost if buried within a composite endpoint. In all these cases, analyses and post hoc analyses of data become relevant in informing practitioners about clinical benefits or safety signals that may not be captured by the primary endpoint. On the other hand, there are many pitfalls in using post hoc determined endpoints. This short review is meant to allow readers to appreciate post hoc analysis not as an entity with a single approach, but rather as an analysis with unique limitations and strengths that often raise new questions to be addressed in further inquiries.

Three occurred debris flows in North-Eastern Italian Alps: documentation and modeling

NASA Astrophysics Data System (ADS)

Boreggio, Mauro; Gregoretti, Carlo; Degetto, Massimo; Bernard, Martino

2015-04-01

Three occurred events of debris flows are documented and modeled by back-analysis. The three debris flows events are those occurred at Rio Lazer on the 4th of November 1966, at Fiames on the 5th of July 2006 and at Rovina di Cancia on the 18th of July 2009. All the three sites are located in the North-Eastern Italian Alps. In all the events, runoff entrained sediments present on natural channels and formed a solid-liquid wave that routed downstream. The first event concerns the routing of debris flow on an inhabited fan. Map of deposition pattern of sediments are built by using post-events photos through stereoscopy techniques. The second event concerns the routing of debris flow along the main channel descending from Pomagagnon Fork. Due to the obstruction of the cross-section debris flow deviated from the original path on the left side and routed downstream by cutting a new channel on the fan. It dispersed in multiple paths when met the wooden area. Map of erosion and deposition depths are built after using a combination of Lidar and GPS data. The third event concerns the routing of debris flow in the Rovina di Cancia channel that filled the reservoir built at the end of the channel and locally overtopped the retaining wall on the left side. A wave of mud and debris inundated the area downstream the overtopping point. Map of erosion and deposition depths are obtained by subtracting two GPS surveys, pre and post event. All the three occurred debris flows are simulated by modeling runoff that entrained debris flow for determining the solid-liquid hydrograph downstream the triggering areas. The routing of the solid-liquid hydrograph was simulated by a bi-phase cell model based on the kinematic approach. The comparison between simulated and measured erosion and deposition depths is satisfactory. The same parameters for computing erosion and deposition were used for the three occurred events.

Survival of teeth treated with cast post and cores: A retrospective analysis over an observation period of up to 19.5 years.

PubMed

Raedel, Michael; Fiedler, Cliff; Jacoby, Stephan; Boening, Klaus W

2015-07-01

Scientific data about the long-term survival of teeth treated with cast post and cores are scarce. Retrospective studies often use different target events for their analyses. A comparison is therefore complicated. For associated tooth-, jaw-, and patient-related factors little evidence exists as to their effect on survival. The purpose of this study was to extend the knowledge on the survival of teeth treated with cast post and cores for observation periods of more than 10 years. A decrease or increase in survival times according to the presence or absence of associated parameters needs to be evaluated. A retrospective evaluation was conducted of all cast post and cores inserted in 1 university clinic between January 1992 and June 2011. A Kaplan-Meier survival analysis was carried out by using extraction as the target event. The survival curves for different tooth types, the presence or absence of adjacent teeth, and the prosthetic restoration of the respective jaws were compared by using the log-rank test (α=.05). A Cox regression model was calculated for multivariate analyses. A total of 717 cast post and cores for 343 patients were recorded. The mean survival time was 13.5 years. A statistically significant decrease in survival times was found for canines (11.9 years) and premolars (13.4 years) versus molars (14.1 years), no adjacent teeth (10.6 years) versus at least 1 adjacent tooth (13.8 years), and the restoration with removable dental prostheses (12.5 years) versus fixed dental prostheses and single crowns (13.9 years). The largest reduction in survival time was found for teeth being used as an abutment for a double crown-retained removable partial dental prosthesis (telescopic denture) (9.8 years). Tooth type and adjacent tooth status remained as significant variables within the multivariate Cox regression model. Cast post and cores have an acceptable long-term survival time. Because different factors may influence survival, considering these factors in treatment planning may increase the long-term success of these restorations. Copyright © 2015 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

Post-earthquake building safety assessments for the Canterbury Earthquakes

USGS Publications Warehouse

Marshall, J.; Barnes, J.; Gould, N.; Jaiswal, K.; Lizundia, B.; Swanson, David A.; Turner, F.

2012-01-01

This paper explores the post-earthquake building assessment program that was utilized in Christchurch, New Zealand following the Canterbury Sequence of earthquakes beginning with the Magnitude (Mw.) 7.1 Darfield event in September 2010. The aftershocks or triggered events, two of which exceeded Mw 6.0, continued with events in February and June 2011 causing the greatest amount of damage. More than 70,000 building safety assessments were completed following the February event. The timeline and assessment procedures will be discussed including the use of rapid response teams, selection of indicator buildings to monitor damage following aftershocks, risk assessments for demolition of red-tagged buildings, the use of task forces to address management of the heavily damaged downtown area and the process of demolition. Through the post-event safety assessment program that occurred throughout the Canterbury Sequence of earthquakes, many important lessons can be learned that will benefit future response to natural hazards that have potential to damage structures.

Analysis of Large Scale Spatial Variability of Soil Moisture Using a Geostatistical Method

DTIC Science & Technology

2010-01-25

2010 / Accepted: 19 January 2010 / Published: 25 January 2010 Abstract: Spatial and temporal soil moisture dynamics are critically needed to...scale observed and simulated estimates of soil moisture under pre- and post-precipitation event conditions. This large scale variability is a crucial... dynamics is essential in the hydrological and meteorological modeling, improves our understanding of land surface–atmosphere interactions. Spatial and

FHR patterns that become significant in connection with ST waveform changes and metabolic acidosis at birth.

PubMed

Rosén, Karl G; Norén, Håkan; Carlsson, Ann

2018-04-18

Recent developments have produced new CTG classification systems and the question is to what extent these may affect the model of FHR + ST interpretation? The two new systems (FIGO2015 and SSOG2017) classify FHR + ST events differently from the current CTG classification system used in the STAN interpretation algorithm (STAN2007). Identify the predominant FHR patterns in connection with ST events in cases of cord artery metabolic acidosis missed by the different CTG classification systems. Indicate to what extent STAN clinical guidelines could be modified enhancing the sensitivity. Provide a pathophysiological rationale. Forty-four cases with umbilical cord artery metabolic acidosis were retrieved from a European multicenter database. Significant FHR + ST events were evaluated post hoc in consensus by an expert panel. Eighteen cases were not identified as in need of intervention and regarded as negative in the sensitivity analysis. In 12 cases, ST changes occurred but the CTG was regarded as reassuring. Visual analysis of the FHR + ST tracings revealed specific FHR patterns: Conclusion: These findings indicate FHR + ST analysis may be undertaken regardless of CTG classification system provided there is a more physiologically oriented approach to FHR assessment in connection with an ST event.

Post-processing of seismic parameter data based on valid seismic event determination

DOEpatents

McEvilly, Thomas V.

1985-01-01

An automated seismic processing system and method are disclosed, including an array of CMOS microprocessors for unattended battery-powered processing of a multi-station network. According to a characterizing feature of the invention, each channel of the network is independently operable to automatically detect, measure times and amplitudes, and compute and fit Fast Fourier transforms (FFT's) for both P- and S- waves on analog seismic data after it has been sampled at a given rate. The measured parameter data from each channel are then reviewed for event validity by a central controlling microprocessor and if determined by preset criteria to constitute a valid event, the parameter data are passed to an analysis computer for calculation of hypocenter location, running b-values, source parameters, event count, P- wave polarities, moment-tensor inversion, and Vp/Vs ratios. The in-field real-time analysis of data maximizes the efficiency of microearthquake surveys allowing flexibility in experimental procedures, with a minimum of traditional labor-intensive postprocessing. A unique consequence of the system is that none of the original data (i.e., the sensor analog output signals) are necessarily saved after computation, but rather, the numerical parameters generated by the automatic analysis are the sole output of the automated seismic processor.

Design and short-term impact of an event to promote careers in clinical pharmacy.

PubMed

Ray, Sarah; Ticcioni, Andrew; Mueller, Robert; Battaglia, Jessica

2018-03-01

There is a role for local pharmacy organizations to promote clinical pharmacy and increase awareness to both potential and current pharmacy students. The Greater Milwaukee College of Clinical Pharmacy (GMCCP) chapter sought to promote clinical pharmacy amongst current and prospective pharmacy students to increase the knowledge, awareness, and interest in clinical pharmacy. Subcommittee members designed programming to introduce the basics of clinical pharmacy. Students from three schools of pharmacy and more than 40 colleges in the region were invited to the event. Didactic and discussion-based content was developed. Pharmacists from GMCCP were solicited as presenters, along with a current pharmacy student and resident. Participants were asked to complete pre-event and post-event surveys to assess their awareness of and interest in clinical pharmacy. Volunteer pharmacists were also surveyed after the event. Twenty-eight individuals attended the event. Nineteen students completed both the pre- and post-survey. The comparison between median score pre- and post-event was analyzed with the Wilcoxon Signed-Rank test. Students' awareness and knowledge of clinical pharmacy improved after attending the event. Students' interest in a career in clinical pharmacy also increased after attending the event. Nine of the thirteen volunteer breakout session pharmacists (69%) responded to the post-event survey. The majority strongly agreed that participants were interested in learning about their area of practice and asked meaningful questions appropriate for their area of practice. The Exploring Careers in Clinical Pharmacy event increased awareness of clinical pharmacy career choices available within the profession of pharmacy. Local, regional, and national pharmacy organizations may consider utilizing the diverse talent of their membership and collaborate with colleges of pharmacy or other organizations to impact the knowledge, awareness, and interest in clinical pharmacy as a future career choice for pre-pharmacy and current pharmacy students. Copyright © 2017 Elsevier Inc. All rights reserved.

["Re-evaluation upon suspected event" is an approach for post-marketing clinical study: lessons from adverse drug events related to Bupleuri Radix preparations].

PubMed

Wu, Shu-Xin; Sun, Hong-Feng; Yang, Xiao-Hui; Long, Hong-Zhu; Ye, Zu-Guang; Ji, Shao-Liang; Zhang, Li

2014-08-01

We revisited the "Xiao Chaihu Decoction event (XCHDE)" occurred in late 1980s in Japan and the Bupleuri Radix related adverse drug reaction (ADR) reports in China After careful review, comparison, analysis and evaluation, we think the interstitial pneumonitis, drug induced Liver injury (DILI) and other severe adverse drug envents (ADEs) including death happened in Japan is probably results from multiple factors, including combinatory use of XCHDE with interferon, Kampo usage under modern medicine theory guidance, and use of XCHD on the basis of disease diagnosis instead of traditional Chinese syndrome complex differentiation. There are less ADE case reports related to XCHD preparation in China compared to Japan, mostly manifest with hypersensitivity responses of skin and perfuse perspiration. The symptoms of Radix Bupleuri injection related ADEs mainly manifest hypersensitivity-like response, 2 cases of intravenous infusion instead of intramuscular injection developed hypokalemia and renal failure. One case died from severe hypersensitivity shock. In Chinese literatures, there is no report of the interstitial pneumonitis and DILI associated with XCHDG in Japan. So far, there is no voluntary monitoring data and large sample clinical research data available. The author elaborated the classification of "reevaluation" and clarified "re-evaluation upon events" included the reaction to the suspected safety and efficacy events. Based on the current status of the clinical research on the Radix Bupleuri preparations, the author points out that post-marketing "re-evaluation upon suspected event" is not only a necessity of continuous evaluation of the safety, efficacy of drugs, it is also a necessity for providing objective clinical research data to share with the international and domestic drug administrations in the risk-benefit evaluation. It is also the unavoidable pathway to culture and push the excellent species and famous brands of TCM to the international market, in that it enhances the pharmaceutical manufactures the ability to control enterprise risk and eliminate the negative impact on traditional Chinese medicine. With the widely used and ADR report concentrated Radix Bupleuri injection as an example, the author provide a new approach to post-marketing clinical research.

Behavioral and functional neuroanatomical correlates of anterograde autobiographical memory in isolated retrograde amnesic patient M.L.

PubMed

Levine, Brian; Svoboda, Eva; Turner, Gary R; Mandic, Marina; Mackey, Allison

2009-09-01

Patient M.L. [Levine, B., Black, S. E., Cabeza, R., Sinden, M., Mcintosh, A. R., Toth, J. P., et al. (1998). Episodic memory and the self in a case of isolated retrograde amnesia. Brain, 121, 1951-1973], lost memory for events occurring before his severe traumatic brain injury, yet his anterograde (post-injury) learning and memory appeared intact, a syndrome known as isolated or focal retrograde amnesia. Studies with M.L. demonstrated a dissociation between episodic and semantic memory. His retrograde amnesia was specific to episodic autobiographical memory. Convergent behavioral and functional imaging data suggested that his anterograde memory, while appearing normal, was accomplished with reduced autonoetic awareness (awareness of the self as a continuous entity across time that is a crucial element of episodic memory). While previous research on M.L. focused on anterograde memory of laboratory stimuli, in this study, M.L.'s autobiographical memory for post-injury events or anterograde autobiographical memory was examined using prospective collection of autobiographical events via audio diary with detailed behavioral and functional neuroanatomical analysis. Consistent with his reports of subjective disconnection from post-injury autobiographical events, M.L. assigned fewer "remember" ratings to his autobiographical events than comparison subjects. His generation of event-specific details using the Autobiographical Interview [Levine, B., Svoboda, E., Hay, J., Winocur, G., & Moscovitch, M. (2002). Aging and autobiographical memory: dissociating episodic from semantic retrieval. Psychology and Aging, 17, 677-689] was low, but not significantly so, suggesting that it is possible to generate episodic-like details even when re-experiencing of those details is compromised. While listening to the autobiographical audio diary segments, M.L. showed reduced activation relative to comparison subjects in midline frontal and posterior nodes previously identified as part of the autobiographical memory network. Reductions were also evident in M.L. in association with personal semantic stimuli (e.g., recordings describing personal habits and routines). These data suggest an association between M.L.'s impoverished recollection of autobiographical material and reduced activation in midline sectors of the autobiographical memory network that support the autonoetic, first-person element of episodic memory.

Intelligent Software Agents: Sensor Integration and Response

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kulesz, James J; Lee, Ronald W

2013-01-01

Abstract In a post Macondo world the buzzwords are Integrity Management and Incident Response Management. The twin processes are not new but the opportunity to link the two is novel. Intelligent software agents can be used with sensor networks in distributed and centralized computing systems to enhance real-time monitoring of system integrity as well as manage the follow-on incident response to changing, and potentially hazardous, environmental conditions. The software components are embedded at the sensor network nodes in surveillance systems used for monitoring unusual events. When an event occurs, the software agents establish a new concept of operation at themore » sensing node, post the event status to a blackboard for software agents at other nodes to see , and then react quickly and efficiently to monitor the scale of the event. The technology addresses a current challenge in sensor networks that prevents a rapid and efficient response when a sensor measurement indicates that an event has occurred. By using intelligent software agents - which can be stationary or mobile, interact socially, and adapt to changing situations - the technology offers features that are particularly important when systems need to adapt to active circumstances. For example, when a release is detected, the local software agent collaborates with other agents at the node to exercise the appropriate operation, such as: targeted detection, increased detection frequency, decreased detection frequency for other non-alarming sensors, and determination of environmental conditions so that adjacent nodes can be informed that an event is occurring and when it will arrive. The software agents at the nodes can also post the data in a targeted manner, so that agents at other nodes and the command center can exercise appropriate operations to recalibrate the overall sensor network and associated intelligence systems. The paper describes the concepts and provides examples of real-world implementations including the Threat Detection and Analysis System (TDAS) at the International Port of Memphis and the Biological Warning and Incident Characterization System (BWIC) Environmental Monitoring (EM) Component. Technologies developed for these 24/7 operational systems have applications for improved real-time system integrity awareness as well as provide incident response (as needed) for production and field applications.« less

Autopsie d'une extinction biologique. Un exemple: la crise de la limite frasnien-famennien (364 ma)

NASA Astrophysics Data System (ADS)

Lethiers, Francis; Casier, Jean-Georges

1999-09-01

Without studying the causes of the F/F boundary mass extinction, the precise analysis of ostracod species shows evolutionary process only discernable at the global scale. About 75% of all neritic species disappeared in the Uppermost Frasnian in all studied regions of the world. Others survived, with some geographic changes, owing to littoral refuges (Lazarus eflect). Deep benthic ostracods seem almost untouched by this event. We show that new post-event species resulted from allopatric speciations by migration between neritic provinces or along continental slopes towards deeper environments. During the event surviving lineages show a continuous gradation from unscathed species to chronocline species, to phyletic subspeciations or speciations (= pseudo extinctions) and even to new genera. The durability of lineages is controlled by the migration of populations.

The impact of occupational hazards and traumatic events among Belgian emergency physicians.

PubMed

Somville, Francis J; De Gucht, Véronique; Maes, Stan

2016-04-27

Emergency Physicians (EPs) are regularly confronted with work related traumatic events and hectic work conditions. Several studies mention a high incidence of post-traumatic stress disorder (PTSD) and psychosomatic complaints in EP. The main objective of this study is to examine the contribution of demographics, traumatic events, life events, the occurrence of occupational hazards and social support to post-traumatic stress symptoms (PTSS), psychological distress, fatigue, somatic complaints and job satisfaction in Emergency Physicians. For this study questionnaires were distributed to Belgian Emergency Physicians, These include, as determinants socio-demographic characteristics, traumatic events, life events, the occurrence of physical hazards, occurrences of violence, occurrence of situations that increase the risk of burnout and social support by supervisors and colleagues (LQWQ-Med), and as outcomes PTSS (IES), psychological distress (BSI), somatic complaints (PHQ 15), perceived fatigue (CIS20 R) and job satisfaction (LQWQ-MD). The response rate was 52.3 %. Hierarchical multiple regression analysis was performed to examine the association between the determinants and each of the outcomes. Emergency Physicians are particularly vulnerable to post-traumatic and chronic stress consequences due to repetitive exposure to work related traumatic incidents such as serious injuries or death of a child/adolescent. One out of three Emergency Physicians met sub-clinical levels of anxiety and 14.5 % met a clinical level of PTSD, short for Post-Traumatic Stress Disorder. Levels of fatigue were high but not directly related to traumatic events and occupational hazards. Social support from colleagues was found to have a beneficial effect on these complaints. Job satisfaction seems to have a protective factor. All of these not only affect the Emergency Physicians themselves, but can also have an adverse impact on patient care. EPs are, according to our and other studies, confronted on a regular basis with significant, potentially traumatizing work related events. There is a higher perception of traumatic events in older Eps. We find out that 36 % of the EPs find dealing with sudden death of a young person and traumatic accident/disease involving a young person the most traumatic experience during their work activity. Three quarter of these EPs have children of their own. The results of the study show that frequency of exposure to traumatic (work) events contributes next to occurrence of situations that increase the risk of burnout to the explanation of variance in posttraumatic stress and psychological distress. The novelty of this study is that it explores the effect of specific determinants of PTSS, psychological distress, fatigue, somatic complaints and job satisfaction in Emergency Physicians. Especially occurrence of situations that increase the risk of burnout seems to have a major impact on all outcomes including job satisfaction, while occurrence of violence contributes especially to psychological distress and perceived fatigue. Lack of social support is a well-known predictor of occupational stress in emergency care workers. In contrast however, good social support of colleagues at work, as we found in our study, can facilitate the recovery process after confrontation with traumatic events and occupational hazards. Emergency Physicians are particularly vulnerable to post-traumatic stress and chronic stress consequences due to repetitive exposure to work related traumatic events. Training in dealing with violence and situations that can increase the risk of burnout can reduce detrimental consequences in emergency physicians. In addition, it is suggested that emergency units are screened systematically on determinants of burnout, in view of interventions. Finally, creating a supportive work environment and training the medical staff in supportive skills with backup by experts may also reduce adverse consequences of confrontation with traumatic work events.

Processing mode during repetitive thinking in socially anxious individuals: evidence for a maladaptive experiential mode.

PubMed

Wong, Quincy J J; Moulds, Michelle L

2012-12-01

Evidence from the depression literature suggests that an analytical processing mode adopted during repetitive thinking leads to maladaptive outcomes relative to an experiential processing mode. To date, in socially anxious individuals, the impact of processing mode during repetitive thinking related to an actual social-evaluative situation has not been investigated. We thus tested whether an analytical processing mode would be maladaptive relative to an experiential processing mode during anticipatory processing and post-event rumination. High and low socially anxious participants were induced to engage in either an analytical or experiential processing mode during: (a) anticipatory processing before performing a speech (Experiment 1; N = 94), or (b) post-event rumination after performing a speech (Experiment 2; N = 74). Mood, cognition, and behavioural measures were employed to examine the effects of processing mode. For high socially anxious participants, the modes had a similar effect on self-reported anxiety during both anticipatory processing and post-event rumination. Unexpectedly, relative to the analytical mode, the experiential mode led to stronger high standard and conditional beliefs during anticipatory processing, and stronger unconditional beliefs during post-event rumination. These experiments are the first to investigate processing mode during anticipatory processing and post-event rumination. Hence, these results are novel and will need to be replicated. These findings suggest that an experiential processing mode is maladaptive relative to an analytical processing mode during repetitive thinking characteristic of socially anxious individuals. Copyright © 2012 Elsevier Ltd. All rights reserved.

Hazards Data Distribution System (HDDS)

USGS Publications Warehouse

Jones, Brenda; Lamb, Rynn M.

2015-07-09

When emergencies occur, first responders and disaster response teams often need rapid access to aerial photography and satellite imagery that is acquired before and after the event. The U.S. Geological Survey (USGS) Hazards Data Distribution System (HDDS) provides quick and easy access to pre- and post-event imagery and geospatial datasets that support emergency response and recovery operations. The HDDS provides a single, consolidated point-of-entry and distribution system for USGS-hosted remotely sensed imagery and other geospatial datasets related to an event response. The data delivery services are provided through an interactive map-based interface that allows emergency response personnel to rapidly select and download pre-event ("baseline") and post-event emergency response imagery.

Analysis of the extreme diversity of salivary alpha-amylase isoforms generated by physiological proteolysis using liquid chromatography-tandem mass spectrometry.

PubMed

Bailey, Ulla-Maja; Punyadeera, Chamindie; Cooper-White, Justin J; Schulz, Benjamin L

2012-12-12

Saliva is a crucial biofluid for oral health and is also of increasing importance as a non-invasive source of disease biomarkers. Salivary alpha-amylase is an abundant protein in saliva, and changes in amylase expression have been previously associated with a variety of diseases and conditions. Salivary alpha-amylase is subject to a high diversity of post-translational modifications, including physiological proteolysis in the oral cavity. Here we developed methodology for rapid sample preparation and non-targeted LC-ESI-MS/MS analysis of saliva from healthy subjects and observed an extreme diversity of alpha-amylase proteolytic isoforms. Our results emphasize the importance of consideration of post-translational events such as proteolysis in proteomic studies, biomarker discovery and validation, particularly in saliva. Copyright © 2012 Elsevier B.V. All rights reserved.

Impact of Consolidation Radiation Therapy in Stage III-IV Diffuse Large B-cell Lymphoma With Negative Post-Chemotherapy Radiologic Imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dorth, Jennifer A., E-mail: jennifer.dorth@duke.edu; Prosnitz, Leonard R.; Broadwater, Gloria

2012-11-01

Purpose: While consolidation radiation therapy (i.e., RT administered after chemotherapy) is routine treatment for patients with early-stage diffuse large B-cell lymphoma (DLBCL), the role of consolidation RT in stage III-IV DLBCL is controversial. Methods and Materials: Cases of patients with stage III-IV DLBCL treated from 1991 to 2009 at Duke University, who achieved a complete response to chemotherapy were reviewed. Clinical outcomes were calculated using the Kaplan-Meier method and were compared between patients who did and did not receive RT, using the log-rank test. A multivariate analysis was performed using Cox proportional hazards model. Results: Seventy-nine patients were identified. Chemotherapymore » (median, 6 cycles) consisted of anti-CD20 antibody rituximab combined with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP; 65%); cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP; 22%); or other (13%). Post-chemotherapy imaging consisted of positron emission tomography (PET)/computed tomography (CT) (73%); gallium with CT (14%); or CT only (13%). Consolidation RT (median, 25 Gy) was given to involved sites of disease in 38 (48%) patients. Receipt of consolidation RT was associated with improved in-field control (92% vs. 69%, respectively, p = 0.028) and event-free survival (85% vs. 65%, respectively, p = 0.014) but no difference in overall survival (85% vs. 78%, respectively, p = 0.15) when compared to patients who did not receive consolidation RT. On multivariate analysis, no RT was predictive of increased risk of in-field failure (hazard ratio [HR], 8.01, p = 0.014) and worse event-free survival (HR, 4.3, p = 0.014). Conclusions: Patients with stage III-IV DLBCL who achieve negative post-chemotherapy imaging have improved in-field control and event-free survival with low-dose consolidation RT.« less

Presence of post-systolic shortening is an independent predictor of heart failure in patients following ST-segment elevation myocardial infarction.

PubMed

Brainin, Philip; Haahr-Pedersen, Sune; Sengeløv, Morten; Olsen, Flemming Javier; Fritz-Hansen, Thomas; Jensen, Jan Skov; Biering-Sørensen, Tor

2018-05-01

Following an ischemic event post systolic shortening (PSS) may occur. We investigated the association between PSS in patients with ST-segment elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (pPCI) and occurrence of cardiovascular events at follow-up. A total of 373 patients admitted with STEMI and treated with pPCI were prospectively included in the study cohort. All patients were examined by echocardiography a median of 2 days after admission (interquartile range, 1-3 days). PSS was measured by color tissue Doppler imaging (TDI) and speckle tracking echocardiography (STE) in six myocardial walls from all three apical projections. During a median follow-up period of 5.4 years (interquartile range, 4.1-6.0 years), 180 events occurred: 59 deaths, 70 heart failures (HF) and 51 new myocardial infarctions (MI). In multivariable analysis adjusting for: age, sex, peak troponin, left ventricle ejection fraction, TIMI flow grade, left ventricle mass index, hypertension and diabetes, presence of PSS by TDI in the culprit region was associated with a nearly twofold increased risk of HF (HR 1.90, 95% CI 1.02-3.53, P = 0.043) and the risk of HF increased incrementally with increasing numbers of walls displaying PSS. The increased risk of HF was confirmed when assessing the post-systolic index by STE (HR 1.29 95% CI 1.09-1.53, P = 0.003, per 1% increase). A regional analysis showed that PSS by TDI in the septal wall was the strongest predictor of HF (HR 1.77, 95% CI 1.08-2.92, P = 0.024). Presence of PSS was not associated with increased risk of death or MI. In patients with STEMI treated with pPCI, the presence of PSS examined by TDI and STE provides prognostic information on development of HF. Presence of PSS in the septal wall is the strongest predictor of HF.

29 CFR 4043.27 - Distribution to a substantial owner.

Code of Federal Regulations, 2014 CFR

2014-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.27 Distribution to a substantial owner. (a) Reportable event. A reportable event occurs for... does not exceed the limitation (as of the date the reportable event occurs) under section 415(b)(1)(A...

29 CFR 4043.28 - Plan merger, consolidation, or transfer.

Code of Federal Regulations, 2012 CFR

2012-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.28 Plan merger, consolidation, or transfer. (a) Reportable event. A reportable event occurs... section 414(1) of the Code. (b) Waivers. Notice is waived for this event. However, notice may be required...

29 CFR 4043.28 - Plan merger, consolidation, or transfer.

Code of Federal Regulations, 2011 CFR

2011-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.28 Plan merger, consolidation, or transfer. (a) Reportable event. A reportable event occurs... section 414(1) of the Code. (b) Waivers. Notice is waived for this event. However, notice may be required...

29 CFR 4043.24 - Termination or partial termination.

Code of Federal Regulations, 2012 CFR

2012-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.24 Termination or partial termination. (a) Reportable event. A reportable event occurs when the... within the meaning of section 411(d)(3) of the Code. (b) Waivers. Notice is waived for this event. ...

29 CFR 4043.24 - Termination or partial termination.

Code of Federal Regulations, 2014 CFR

2014-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.24 Termination or partial termination. (a) Reportable event. A reportable event occurs when the... within the meaning of section 411(d)(3) of the Code. (b) Waivers. Notice is waived for this event. ...

29 CFR 4043.28 - Plan merger, consolidation, or transfer.

Code of Federal Regulations, 2014 CFR

2014-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.28 Plan merger, consolidation, or transfer. (a) Reportable event. A reportable event occurs... section 414(1) of the Code. (b) Waivers. Notice is waived for this event. However, notice may be required...

29 CFR 4043.27 - Distribution to a substantial owner.

Code of Federal Regulations, 2011 CFR

2011-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.27 Distribution to a substantial owner. (a) Reportable event. A reportable event occurs for... does not exceed the limitation (as of the date the reportable event occurs) under section 415(b)(1)(A...

29 CFR 4043.27 - Distribution to a substantial owner.

Code of Federal Regulations, 2013 CFR

2013-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.27 Distribution to a substantial owner. (a) Reportable event. A reportable event occurs for... does not exceed the limitation (as of the date the reportable event occurs) under section 415(b)(1)(A...

29 CFR 4043.27 - Distribution to a substantial owner.

Code of Federal Regulations, 2010 CFR

2010-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.27 Distribution to a substantial owner. (a) Reportable event. A reportable event occurs for... does not exceed the limitation (as of the date the reportable event occurs) under section 415(b)(1)(A...

29 CFR 4043.24 - Termination or partial termination.

Code of Federal Regulations, 2013 CFR

2013-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.24 Termination or partial termination. (a) Reportable event. A reportable event occurs when the... within the meaning of section 411(d)(3) of the Code. (b) Waivers. Notice is waived for this event. ...

29 CFR 4043.27 - Distribution to a substantial owner.

Code of Federal Regulations, 2012 CFR

2012-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.27 Distribution to a substantial owner. (a) Reportable event. A reportable event occurs for... does not exceed the limitation (as of the date the reportable event occurs) under section 415(b)(1)(A...

29 CFR 4043.24 - Termination or partial termination.

Code of Federal Regulations, 2011 CFR

2011-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.24 Termination or partial termination. (a) Reportable event. A reportable event occurs when the... within the meaning of section 411(d)(3) of the Code. (b) Waivers. Notice is waived for this event. ...

29 CFR 4043.28 - Plan merger, consolidation, or transfer.

Code of Federal Regulations, 2013 CFR

2013-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.28 Plan merger, consolidation, or transfer. (a) Reportable event. A reportable event occurs... section 414(1) of the Code. (b) Waivers. Notice is waived for this event. However, notice may be required...

29 CFR 4043.28 - Plan merger, consolidation, or transfer.

Code of Federal Regulations, 2010 CFR

2010-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.28 Plan merger, consolidation, or transfer. (a) Reportable event. A reportable event occurs... section 414(1) of the Code. (b) Waivers. Notice is waived for this event. However, notice may be required...

29 CFR 4043.24 - Termination or partial termination.

Code of Federal Regulations, 2010 CFR

2010-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.24 Termination or partial termination. (a) Reportable event. A reportable event occurs when the... within the meaning of section 411(d)(3) of the Code. (b) Waivers. Notice is waived for this event. ...

Using multiple sources of data for surveillance of postoperative venous thromboembolism among surgical patients treated in Department of Veterans Affairs hospitals, 2005-2010.

PubMed

Nelson, Richard E; Grosse, Scott D; Waitzman, Norman J; Lin, Junji; DuVall, Scott L; Patterson, Olga; Tsai, James; Reyes, Nimia

2015-04-01

There are limitations to using administrative data to identify postoperative venous thromboembolism (VTE). We used a novel approach to quantify postoperative VTE events among Department of Veterans Affairs (VA) surgical patients during 2005-2010. We used VA administrative data to exclude patients with VTE during 12 months prior to surgery. We identified probable postoperative VTE events within 30 and 90 days post-surgery in three settings: 1) pre-discharge inpatient, using a VTE diagnosis code and a pharmacy record for anticoagulation; 2) post-discharge inpatient, using a VTE diagnosis code followed by a pharmacy record for anticoagulation within 7 days; and 3) outpatient, using a VTE diagnosis code and either anticoagulation or a therapeutic procedure code with natural language processing (NLP) to confirm acute VTE in clinical notes. Among 468,515 surgeries without prior VTE, probable VTEs were documented within 30 and 90 days in 3,931 (0.8%) and 5,904 (1.3%), respectively. Of probable VTEs within 30 or 90 days post-surgery, 47.8% and 62.9%, respectively, were diagnosed post-discharge. Among post-discharge VTE diagnoses, 86% resulted in a VA hospital readmission. Fewer than 25% of outpatient records with both VTE diagnoses and anticoagulation prescriptions were confirmed by NLP as acute VTE events. More than half of postoperative VTE events were diagnosed post-discharge; analyses of surgical discharge records are inadequate to identify postoperative VTE. The NLP results demonstrate that the combination of VTE diagnoses and anticoagulation prescriptions in outpatient administrative records cannot be used to validly identify postoperative VTE events. Copyright © 2015. Published by Elsevier Ltd.

Using multiple sources of data for surveillance of postoperative venous thromboembolism among surgical patients treated in Department of Veterans Affairs hospitals, 2005–2010

PubMed Central

Nelson, Richard E.; Grosse, Scott D.; Waitzman, Norman J.; Lin, Junji; DuVall, Scott L.; Patterson, Olga; Tsai, James; Reyes, Nimia

2015-01-01

Background There are limitations to using administrative data to identify postoperative venous thromboembolism (VTE). We used a novel approach to quantify postoperative VTE events among Department of Veterans Affairs (VA) surgical patients during 2005–2010. Methods We used VA administrative data to exclude patients with VTE during 12 months prior to surgery. We identified probable postoperative VTE events within 30 and 90 days post-surgery in three settings: 1) pre-discharge inpatient, using a VTE diagnosis code and a pharmacy record for anticoagulation; 2) post-discharge inpatient, using a VTE diagnosis code followed by a pharmacy record for anticoagulation within 7 days; and 3) outpatient, using a VTE diagnosis code and either anticoagulation or a therapeutic procedure code with natural language processing (NLP) to confirm acute VTE in clinical notes. Results Among 468,515 surgeries without prior VTE, probable VTEs were documented within 30 and 90 days in 3,931 (0.8%) and 5,904 (1.3%), respectively. Of probable VTEs within 30 or 90 days post-surgery, 47.8% and 62.9%, respectively, were diagnosed post-discharge. Among post-discharge VTE diagnoses, 86% resulted in a VA hospital readmission. Fewer than 25% of outpatient records with both VTE diagnoses and anticoagulation prescriptions were confirmed by NLP as acute VTE events. Conclusion More than half of postoperative VTE events were diagnosed post-discharge; analyses of surgical discharge records are inadequate to identify postoperative VTE. The NLP results demonstrate that the combination of VTE diagnoses and anticoagulation prescriptions in outpatient administrative records cannot be used to validly identify postoperative VTE events. PMID:25666908

The Relationship between Post-Traumatic Symptoms, Parenting Style, and Resilience among Adolescents in Liaoning, China: A Cross-Sectional Study.

PubMed

Zhai, Yanxue; Liu, Kun; Zhang, Lin; Gao, Han; Chen, Zhuo; Du, Siyi; Zhang, Lili; Guo, Yu

2015-01-01

In China, a growing number of adolescents have experienced traumatic events that have resulted in PTSD (post-traumatic stress disorder). Post-traumatic symptoms are common psychological problems in adolescents who have experienced traumatic events. However, existing studies tend to focus on the factors influencing PTSD, such as the response styles and social support, and studies on the relationships between parenting style, resilience and post-traumatic symptoms are still rare. To analyze the relationships between parenting style, resilience and post-traumatic symptoms among adolescents in China. A cross-sectional survey was conducted from June to December 2013 in the Liaoning Province, China. N = 5765 adolescents (aged 12 to 18 years old) were ultimately chosen to participate. The Chinese version of the Essen Trauma Inventory for Kids and Juveniles (ETI-KJ), a modified version of the Parental Authority Questionnaire, and the Chinese Resilience Scale were used to estimate the post-traumatic symptoms, parenting style, and resilience, respectively. Pearson's correlations, multiple linear regression analyses and structural equation modeling (SEM) were applied to analyze the data. Of the adolescents, 39.76% (N = 2292) had been exposed to traumatic events during their lives. The prevalence of probable PTSD at the time of the interview (one-month-prevalence) was 12.65%. Parenting style and resilience were significantly associated with post-traumatic symptoms. According to the SEM, parenting style had a significant direct effect on resilience (0.70, P<0.01) and post-traumatic symptoms (-0.15, P<0.05), and resilience had a significant direct effect on the post-traumatic symptoms (-0.43, P<0.01). Furthermore, parenting style had a significant indirect effect (-0.43×0.70 = -0.30. P<0.01) on the post-traumatic symptoms through resilience. The SEM significantly explained 49% of the variance in resilience and 30% of the variance in post-traumatic symptoms. Parenting style and resilience have significant effects on adolescents' post-traumatic symptoms. Schools and social-related departments could share knowledge on the impact of parenting style with parents enabling them to improve their own parenting style and their children's resilience and ability to respond effectively to traumatic events.

Omitting details from post-event information: are true and false memory affected in the same way?

PubMed

Loehr, Janeen D; Marche, Tammy A

2006-01-01

Participants who witness an event and later receive post-event information that omits a critical scene are less likely to recall and to recognise that scene than are participants who receive no post-event information (Wright, Loftus, & Hall, 2001). The present study used the Deese-Roediger-McDermott (DRM) paradigm, in which participants study lists of semantic associates (e.g., hot, snow, warm, winter) that commonly elicit false memories of critical non-presented words (e.g., cold), to determine whether omitting information from a second presentation decreases memory for both presented and non-presented information. Participants were presented with a list of the semantic associates of six non-presented words. For half the participants, this list was presented a second time with the semantic associates of one of the non-presented words omitted. As expected, participants were less likely to recall and to recognise the presented words when they had been omitted from the second presentation. Omission also decreased the rate at which non-presented words were recalled, although false recognition of these words was not reduced. These results suggest that false recognition may be particularly difficult to attenuate and that post-event omission may be more detrimental to memory accuracy than previously thought.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Taylor, L.L.; Wilson, J.R.; Sanchez, L.C.

The United States Department of Energy Office of Environmental Management's (DOE/EM's) National Spent Nuclear Fuel Program (NSNFP), through a collaboration between Sandia National Laboratories (SNL) and Idaho National Engineering and Environmental Laboratory (INEEL), is conducting a systematic Nuclear Dynamics Consequence Analysis (NDCA) of the disposal of SNFs in an underground geologic repository sited in unsaturated tuff. This analysis is intended to provide interim guidance to the DOE for the management of the SNF while they prepare for final compliance evaluation. This report presents results from a Nuclear Dynamics Consequence Analysis (NDCA) that examined the potential consequences and risks of criticalitymore » during the long-term disposal of spent nuclear fuel owned by DOE-EM. This analysis investigated the potential of post-closure criticality, the consequences of a criticality excursion, and the probability frequency for post-closure criticality. The results of the NDCA are intended to provide the DOE-EM with a technical basis for measuring risk which can be used for screening arguments to eliminate post-closure criticality FEPs (features, events and processes) from consideration in the compliance assessment because of either low probability or low consequences. This report is composed of an executive summary (Volume 1), the methodology and results of the NDCA (Volume 2), and the applicable appendices (Volume 3).« less

29 CFR 4043.30 - Liquidation.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.30 Liquidation. (a) Reportable event. A reportable event occurs for a plan when a member of the plan's controlled group— (1) Is...

29 CFR 4043.30 - Liquidation.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.30 Liquidation. (a) Reportable event. A reportable event occurs for a plan when a member of the plan's controlled group— (1) Is...

29 CFR 4043.30 - Liquidation.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.30 Liquidation. (a) Reportable event. A reportable event occurs for a plan when a member of the plan's controlled group— (1) Is...

29 CFR 4043.30 - Liquidation.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.30 Liquidation. (a) Reportable event. A reportable event occurs for a plan when a member of the plan's controlled group— (1) Is...

Becoming a "second victim" in health care: Pathway of recovery after adverse event.

PubMed

Rinaldi, C; Leigheb, F; Vanhaecht, K; Donnarumma, C; Panella, M

2016-07-01

The healthcare worker involved in an unanticipated adverse patient event can become second victim. These workers suffer physically and psycho-socially and try to overcome the post-event emotional stress by obtaining emotional support in a variety of ways. The goal of this research was to study second victims among health care providers in Italy. This contribution contains the results of 33 interviews of nurses, physicians and other healthcare workers. After institutional approval, the semi-structured interview, composed of 25 questions, was translated from English into Italian. The audio-interviews were transcribed on paper verbatim by the interviewer. It was then verified if the interviewees experienced the six post-event stages of second victim recovery previously described within the literature. The interviewees described the post-event recovery stages described by literature but stages were not detailed in the exact succession order as the American study. All participants clearly remembered the adverse event and referred the physical and psycho-social symptoms. The psychological support obtained by second victims was described as poor and inefficient. The post-event recovery pathway is predictable but not always clearly respected as defined within this Italian sample. Future study of the second-victim phenomenon and desired supportive interventions is necessary to understand the experience and interventions to mitigate harm of future clinicians. Every day healthcare workers become second victims and, considering that human resources are the most important heritage of healthcare infrastructures, after an adverse event it is very important to execute valid interventional programs to support and train these workers. Copyright © 2016 SECA. Publicado por Elsevier España, S.L.U. All rights reserved.

Analysing Time to Event Data in Dementia Prevention Trials: The Example of the GuidAge Study of EGb761.

PubMed

Scherrer, B; Andrieu, S; Ousset, P J; Berrut, G; Dartigues, J F; Dubois, B; Pasquier, F; Piette, F; Robert, P; Touchon, J; Garnier, P; Mathiex-Fortunet, H; Vellas, B

2015-12-01

Time-to-event analysis is frequently used in medical research to investigate potential disease-modifying treatments in neurodegenerative diseases. Potential treatment effects are generally evaluated using the logrank test, which has optimal power and sensitivity when the treatment effect (hazard ratio) is constant over time. However, there is generally no prior information as to how the hazard ratio for the event of interest actually evolves. In these cases, the logrank test is not necessarily the most appropriate to use. When the hazard ratio is expected to decrease or increase over time, alternative statistical tests such as the Fleming-Harrington test, provide a better sensitivity. An example of this comes from a large, five-year randomised, placebo-controlled prevention trial (GuidAge) in 2854 community-based subjects making spontaneous memory complaints to their family physicians, which evaluated whether treatment with EGb761 can modify the risk of developing AD. The primary outcome measure was the time to conversion from memory complaint to Alzheimer's type dementia. Although there was no significant difference in the hazard function of conversion between the two treatment groups according to the preplanned logrank test, a significant treatment-by-time interaction for the incidence of AD was observed in a protocol-specified subgroup analysis, suggesting that the hazard ratio is not constant over time. For this reason, additional post hoc analyses were performed using the Fleming-Harrington test to evaluate whether there was a signal of a late effect of EGb761. Applying the Fleming-Harrington test, the hazard function for conversion to dementia in the placebo group was significantly different from that in the EGb761 treatment group (p = 0.0054), suggesting a late effect of EGb761. Since this was a post hoc analysis, no definitive conclusions can be drawn as to the effectiveness of the treatment. This post hoc analysis illustrates the interest of performing another randomised clinical trial of EGb761 explicitly testing the hypothesis of a late treatment effect, as well as of using of better adapted statistical approaches for long term preventive trials when it is expected that prevention cannot have an immediate effect but rather a delayed effect that increases over time.

Near Real Time Analytics of Human Sensor Networks in the Realm of Big Data

NASA Astrophysics Data System (ADS)

Aulov, O.; Halem, M.

2012-12-01

With the prolific development of social media, emergency responders have an increasing interest in harvesting social media from outlets such as Flickr, Twitter, and Facebook, in order to assess the scale and specifics of extreme events including wild fires, earthquakes, terrorist attacks, oil spills, etc. A number of experimental platforms have successfully been implemented to demonstrate the utilization of social media data in extreme events, including Twitter Earthquake Detector, which relied on tweets for earthquake monitoring; AirTwitter, which used tweets for air quality reporting; and our previous work, using Flickr data as boundary value forcings to improve the forecast of oil beaching in the aftermath of the Deepwater Horizon oil spill. The majority of these platforms addressed a narrow, specific type of emergency and harvested data from a particular outlet. We demonstrate an interactive framework for monitoring, mining and analyzing a plethora of heterogeneous social media sources for a diverse range of extreme events. Our framework consists of three major parts: a real time social media aggregator, a data processing and analysis engine, and a web-based visualization and reporting tool. The aggregator gathers tweets, Facebook comments from fan pages, Google+ posts, forum discussions, blog posts (such as LiveJournal and Blogger.com), images from photo-sharing platforms (such as Flickr, Picasa), videos from video-sharing platforms (youtube, Vimeo), and so forth. The data processing and analysis engine pre-processes the aggregated information and annotates it with geolocation and sentiment information. In many cases, the metadata of the social media posts does not contain geolocation information—-however, a human reader can easily guess from the body of the text what location is discussed. We are automating this task by use of Named Entity Recognition (NER) algorithms and a gazetteer service. The visualization and reporting tool provides a web-based, user-friendly interface that provides time-series analysis and plotting tools, geo-spacial visualization tools with interactive maps, and cause-effect inference tools. We demonstrate how we address big data challenges of monitoring, aggregating and analyzing vast amounts of social media data at a near realtime. As a result, our framework not only allows emergency responders to augment their situational awareness with social media information, but can also allow them to extract geophysical data and incorporate it into their analysis models.

n-3 Fatty Acids, Ventricular Arrhythmia–Related Events, and Fatal Myocardial Infarction in Postmyocardial Infarction Patients With Diabetes

PubMed Central

Kromhout, Daan; Geleijnse, Johanna M.; de Goede, Janette; Oude Griep, Linda M.; Mulder, Barbara J.M.; de Boer, Menko-Jan; Deckers, Jaap W.; Boersma, Eric; Zock, Peter L.; Giltay, Erik J.

2011-01-01

OBJECTIVE We carried out a secondary analysis in high-risk patients with a previous myocardial infarction (MI) and diabetes in the Alpha Omega Trial. We tested the hypothesis that in these patients an increased intake of the n-3 fatty acids eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and α-linolenic acid (ALA) will reduce the incidence of ventricular arrhythmias and fatal MI. RESEARCH DESIGN AND METHODS A subgroup of 1,014 post-MI patients with diabetes aged 60–80 years was randomly allocated to receive one of four trial margarines, three with an additional amount of n-3 fatty acids and one placebo for 40 months. The end points were ventricular arrhythmia–related events and fatal MI. The data were analyzed according to the intention-to-treat principle, using multivariable Cox proportional hazards models. RESULTS The patients consumed on average 18.6 g of margarine per day, which resulted in an additional intake of 223 mg EPA plus 149 mg DHA and/or 1.9 g ALA in the active treatment groups. During follow-up, 29 patients developed a ventricular arrhythmia–related events and 27 had a fatal MI. Compared with placebo patients, the EPA-DHA plus ALA group experienced less ventricular arrhythmia–related events (hazard ratio 0.16; 95% CI 0.04–0.69). These n-3 fatty acids also reduced the combined end-point ventricular arrhythmia–related events and fatal MI (0.28; 0.11–0.71). CONCLUSIONS Our results suggest that low-dose supplementation of n-3 fatty acids exerts a protective effect against ventricular arrhythmia–related events in post-MI patients with diabetes. PMID:22110169

Influence of legislations and news on Indian internet search query patterns of e-cigarettes.

PubMed

Thavarajah, Rooban; Mohandoss, Anusa Arunachalam; Ranganathan, Kannan; Kondalsamy-Chennakesavan, Srinivas

2017-01-01

There is a paucity of data on the use of electronic nicotine delivery systems (ENDS) in India. In addition, the Indian internet search pattern for ENDS has not been studied. We aimed to address this lacuna. Moreover, the influence of the tobacco legislations and news pieces on such search volume is not known. Given the fact that ENDS could cause oral lesions, these data are pertinent to dentists. Using a time series analysis, we examined the effect of tobacco-related legislations and news pieces on total search volume (TSV) from September 1, 2012, to August 31, 2016. TSV data were seasonally adjusted and analyzed using time series modeling. The TSV clocked during the month of legislations and news pieces were analyzed for their influence on search pattern of ENDS. The overall mean ± standard deviation (range) TSV was 22273.75 ± 6784.01 (12310-40510) during the study with seasonal variations. Individually, the best model for TSV-legislation and news pieces was autoregressive integrated moving average model, and when influence of legislations and news events were combined, it was the Winter's additive model. In the legislation alone model, the pre-event, event and post-event month TSV was not a better indicator of the effect, barring for post-event month of 2 nd legislation, which involved pictorial warnings on packages in the study period. Similarly, a news piece on Pan-India ban on ENDS influenced the model in the news piece model. When combined, no "events" emerged significant. These findings suggest that search for information on ENDS is increasing and that these tobacco control policies and news items, targeting tobacco usage reduction, have only a short-term effect on the rate of searching for information on ENDS.

Post-traumatic stress disorder and cardiovascular disease.

PubMed

Edmondson, Donald; von Känel, Roland

2017-04-01

In this paper, a first in a Series of two, we look at the evidence for an association of post-traumatic stress disorder with incident cardiovascular disease risk and the mechanisms that might cause this association, as well as the prevalence of post-traumatic stress disorder due to cardiovascular disease events and its associated prognostic risk. We discuss research done after the publication of previous relevant systematic reviews, and survey currently funded research from the two most active funders in the field: the National Institutes of Health and the US Veterans Administration. We conclude that post-traumatic stress disorder is a risk factor for incident cardiovascular disease, and a common psychiatric consequence of cardiovascular disease events that might worsen the prognosis of the cardiovascular disease. There are many candidate mechanisms for the link between post-traumatic stress disorder and cardiovascular disease, and several ongoing studies could soon point to the most important behavioural and physiological mechanisms to target in early phase intervention development. Similarly, targets are emerging for individual and environmental interventions that might offset the risk of post-traumatic stress disorder after cardiovascular disease events. Copyright © 2017 Elsevier Ltd. All rights reserved.

Studying the hydro-meteorological extremes. The benefits from the European Flash Flood research oriented HYDRATE project.

NASA Astrophysics Data System (ADS)

Tsanis, Ioannis K.; Koutroulis, Aristeidis G.; Daliakopoulos, Ioannis N.; Grillakis, Emmanouil G.

2010-05-01

The present paper summarizes the advances of flash flood research for the Greek case study, within the frame of HYDRATE EC funded project. As a first step, a collation of homogenous primary data on flash floods occurred in Greece based on various data sources resulted in 21 documented events, enriching the HYDRATE database. Specific major events were selected for further detailed data collation and analysis. A common intensive post event field survey was conducted by various researchers with different skills and experience, in order to document the 18th of September 2007, Western Slovenia flash flood event. The observation strategy and the lessons learned during this campaign were applied successfully for surveying an event in Crete. Two flash flood events occurred in Crete were selected for detailed analysis, the 13th of January 1994 event occurred in Giofiros basin and the 17th of October 2006 event occurred in Almirida basin. Several techniques, like distributed rainfall-runoff modelling, hydraulic modelling, indirect and empirical peak discharge estimation, were applied for the understanding of the dominant flash flood processes and the effect of initial conditions on peak discharge. In a more general framework, the seasonality of the hydrometeorologic characteristics of floods that occurred in Crete during the period 1990-2007 and the atmospheric circulation conditions during the flood events were examined. During the three and a half years research period, many lessons have learnt from a fruitful collaboration among the project partners. HYDRATE project improved the scientific basis of flash flood research and provided research knowledge on flood risk management.

Autobiographical integration of trauma memories and repressive coping predict post-traumatic stress symptoms in undergraduate students.

PubMed

Smeets, Tom; Giesbrecht, Timo; Raymaekers, Linsey; Shaw, Julia; Merckelbach, Harald

2010-01-01

What differentiates those who are able to adapt well to adverse life events (i.e., persons who are resilient) from those who are not (e.g., persons who develop post-traumatic stress symptoms)? Previous work suggests that enhanced autobiographical integration of trauma memories is associated with more severe post-traumatic stress symptoms. Extending this line of work, the present study looked at whether the integration of trauma memories, repressive coping and cognitive reactivity are related to post-traumatic stress symptomatology following negative life events among otherwise healthy young adults (N = 213). Results show that while enhanced integration of trauma memories and high levels of dissociation are related to elevated levels of post-traumatic stress, people who generally engage in repressive coping report fewer post-traumatic stress symptoms. Copyright (c) 2009 John Wiley & Sons, Ltd.

Comparison of relative and actual chest compression depths during cardiac arrest in children, adolescents, and young adults☆

PubMed Central

Niles, Dana E.; Nishisaki, Akira; Sutton, Robert M.; Nysæther, Jon; Eilevstjønn, Joar; Leffelman, Jessica; Maltese, Matthew R.; Arbogast, Kristy B.; Abella, Benjamin S.; Helfaer, Mark A.; Berg, Robert A.; Nadkarni, Vinay M.

2013-01-01

Aim Cardiopulmonary resuscitation (CPR) guidelines recommend specific chest compression (CC) target depths for children. We quantitatively describe relative anterior–posterior diameter (APD) depth, actual depth, and force of CCs during real CPR events in children. Methods CC depth and force were recorded during real CPR events in children ≥8 years using FDA-approved CC sensor. Patient chest APD was measured at conclusion of each CPR event. CC data was stratified and analyzed according to age (pre-puberty, 8–14 years; post-puberty, 15+ years). Relative (% APD) and actual CC depth, corrected for mattress deflection, were assessed and compared with American Heart Association (AHA) 2005 and 2010 pediatric CPR guidelines. Results 35 events in 32 subjects included 16,158 CCs for data analysis: 16 pre-puberty (CCs = 7484, age 11.9 ± 2 years, APD 164.6 ± 25.1 mm); 19 post-puberty (CCs = 8674, age 18.0 ± 2.7 years, APD 196.5 ± 30.4 mm). After correction for mattress deflection, 92% of CC delivered to pre-puberty were <1/3 relative APD and 60% of CC were <38 mm actual depth. Mean actual CC depth (36.2 ± 9.6 mm vs. 36.8 ± 9.9 mm, p = 0.64), mean relative APD (22.5% ± 7.0% vs. 19.5 ± 6.7%, p = 0.13), and mean CC force (30.7 ± 7.6 kg vs. 33.6 ± 9.4 kg, p = 0.07) were not significantly less in pre-puberty vs. post-puberty. Conclusions During in-hospital cardiac arrest of children ≥8 years, CCs delivered by resuscitation teams were frequently <1/3 relative APD and <38 mm actual depth after mattress deflection correction, below pediatric and adult target guidelines. Mean CC actual depth and force were not significantly different in pre-puberty and post-puberty. Additional investigation to determine depth of CCs to optimize hemodynamics and outcomes is needed to inform future CPR guidelines. PMID:22079410

Multi-purpose ECG telemetry system.

PubMed

Marouf, Mohamed; Vukomanovic, Goran; Saranovac, Lazar; Bozic, Miroslav

2017-06-19

The Electrocardiogram ECG is one of the most important non-invasive tools for cardiac diseases diagnosis. Taking advantage of the developed telecommunication infrastructure, several approaches that address the development of telemetry cardiac devices were introduced recently. Telemetry ECG devices allow easy and fast ECG monitoring of patients with suspected cardiac issues. Choosing the right device with the desired working mode, signal quality, and the device cost are still the main obstacles to massive usage of these devices. In this paper, we introduce design, implementation, and validation of a multi-purpose telemetry system for recording, transmission, and interpretation of ECG signals in different recording modes. The system consists of an ECG device, a cloud-based analysis pipeline, and accompanied mobile applications for physicians and patients. The proposed ECG device's mechanical design allows laypersons to easily record post-event short-term ECG signals, using dry electrodes without any preparation. Moreover, patients can use the device to record long-term signals in loop and holter modes, using wet electrodes. In order to overcome the problem of signal quality fluctuation due to using different electrodes types and different placements on subject's chest, customized ECG signal processing and interpretation pipeline is presented for each working mode. We present the evaluation of the novel short-term recorder design. Recording of an ECG signal was performed for 391 patients using a standard 12-leads golden standard ECG and the proposed patient-activated short-term post-event recorder. In the validation phase, a sample of validation signals followed peer review process wherein two experts annotated the signals in terms of signal acceptability for diagnosis.We found that 96% of signals allow detecting arrhythmia and other signal's abnormal changes. Additionally, we compared and presented the correlation coefficient and the automatic QRS delineation results of both short-term post-event recorder and 12-leads golden standard ECG recorder. The proposed multi-purpose ECG device allows physicians to choose the working mode of the same device according to the patient status. The proposed device was designed to allow patients to manage the technical requirements of both working modes. Post-event short-term ECG recording using the proposed design provide physicians reliable three ECG leads with direct symptom-rhythm correlation.

[Natural disasters and health: an analysis of the situation in Brazil].

PubMed

Freitas, Carlos Machado de; Silva, Diego Ricardo Xavier; Sena, Aderita Ricarda Martins de; Silva, Eliane Lima; Sales, Luiz Belino Ferreira; Carvalho, Mauren Lopes de; Mazoto, Maíra Lopes; Barcellos, Christovam; Costa, André Monteiro; Oliveira, Mara Lúcia Carneiro; Corvalán, Carlos

2014-09-01

Natural disasters are still insufficiently studied and understood within the scope of public health in this country, with impacts in the short and long term. The scope of this article is to analyze the relationship between disasters and their impact on health based on disaster data recorded in the country. The methodology involved the systematization of data and information contained in the Brazilian Atlas of Natural Disasters 1991-2010 and directly from the National Department of Civil Defense (NSCD). Disasters were organized into four categories of events (meteorological; hydrological; climatological; geophysical/geological) and for each of the latter, the data for morbidity, mortality and exposure of those affected were examined, revealing different types of impacts. Three categories of disasters stood out: the hydrological events showed higher percentages of mortality, morbidity and exposure; climatological events had higher percentages of incidents and people affected; the geophysical/geological events had a higher average of exposure and deaths per event. Lastly, a more active participation of the health sector in the post-2015 global political agenda is proposed, particularly events related to sustainable development, climate change and disaster risk reduction.

Efficacy and safety of alirocumab in reducing lipids and cardiovascular events.

PubMed

Robinson, Jennifer G; Farnier, Michel; Krempf, Michel; Bergeron, Jean; Luc, Gérald; Averna, Maurizio; Stroes, Erik S; Langslet, Gisle; Raal, Frederick J; El Shahawy, Mahfouz; Koren, Michael J; Lepor, Norman E; Lorenzato, Christelle; Pordy, Robert; Chaudhari, Umesh; Kastelein, John J P

2015-04-16

Alirocumab, a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9), has been shown to reduce low-density lipoprotein (LDL) cholesterol levels in patients who are receiving statin therapy. Larger and longer-term studies are needed to establish safety and efficacy. We conducted a randomized trial involving 2341 patients at high risk for cardiovascular events who had LDL cholesterol levels of 70 mg per deciliter (1.8 mmol per liter) or more and were receiving treatment with statins at the maximum tolerated dose (the highest dose associated with an acceptable side-effect profile), with or without other lipid-lowering therapy. Patients were randomly assigned in a 2:1 ratio to receive alirocumab (150 mg) or placebo as a 1-ml subcutaneous injection every 2 weeks for 78 weeks. The primary efficacy end point was the percentage change in calculated LDL cholesterol level from baseline to week 24. At week 24, the difference between the alirocumab and placebo groups in the mean percentage change from baseline in calculated LDL cholesterol level was -62 percentage points (P<0.001); the treatment effect remained consistent over a period of 78 weeks. The alirocumab group, as compared with the placebo group, had higher rates of injection-site reactions (5.9% vs. 4.2%), myalgia (5.4% vs. 2.9%), neurocognitive events (1.2% vs. 0.5%), and ophthalmologic events (2.9% vs. 1.9%). In a post hoc analysis, the rate of major adverse cardiovascular events (death from coronary heart disease, nonfatal myocardial infarction, fatal or nonfatal ischemic stroke, or unstable angina requiring hospitalization) was lower with alirocumab than with placebo (1.7% vs. 3.3%; hazard ratio, 0.52; 95% confidence interval, 0.31 to 0.90; nominal P=0.02). Over a period of 78 weeks, alirocumab, when added to statin therapy at the maximum tolerated dose, significantly reduced LDL cholesterol levels. In a post hoc analysis, there was evidence of a reduction in the rate of cardiovascular events with alirocumab. (Funded by Sanofi and Regeneron Pharmaceuticals; ODYSSEY LONG TERM ClinicalTrials.gov number, NCT01507831.).

Dealing with Natural Disasters: Preparedness versus Post-Event Response

NASA Astrophysics Data System (ADS)

Sitar, N.

2015-12-01

Management or mitigation of natural disasters is comprised of two distinct elements: disaster preparedness and disaster response. Fundamentally disasters fall into two categories: 1) those whose timing can be predicted and evaluated in advance, such as hurricanes, floods, tsunamis, or even sea level rise; and 2) those that can be anticipated based on analysis, but their exact timing is unknown, such as earthquakes and landslides. Consequently, the type of response and options available for scientific and engineering consultation are fundamentally different. The common aspects of all natural disasters is that there is evidence of past events either historical or geologic, or both. Thus, given past evidence, scientists and engineers have an opportunity to recommend and guide development and implementation of long term or permanent mitigation measures, such as improving the resiliency of the infrastructure and emergency preparedness. However, the appropriate mitigation measures are very much a function of the type of event. Severe atmospheric events, such as hurricanes, typically can be predicted several days in advance and scientists and engineers have a role in guiding preparation of specific additional, temporary, mitigation measures and selective evacuation, as appropriate. In contrast, while earthquake potential of a given region may be well recognized, the actual timing of the event is an unknown and, consequently, the primary defense is in developing sufficiently resilient infrastructure which can be enhanced with early warning systems. Similarly, the type of damage caused by flooding, e.g. hurricane and tsunami, is significantly different from the type of damage caused by an earthquake in that flooding damage is pervasive affecting large contiguous areas wiping out all infrastructure whereas earthquake or landslide damage tends to be clustered with many elements of infrastructure remaining fully or somewhat operable. This distinction is very important when it comes to the type of technical guidance that is needed following such events. This presentation highlights lessons learned from post-event reconnaissance as a part of the NSF-funded Geotechnical Extreme Event Reconnaissance (GEER) over the last two decades.

38 CFR 42.36 - Post-hearing briefs.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) STANDARDS IMPLEMENTING THE PROGRAM FRAUD CIVIL REMEDIES ACT § 42.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Post-hearing briefs. 42...

12 CFR 308.535 - Post-hearing briefs.

Code of Federal Regulations, 2011 CFR

2011-01-01

... PRACTICE AND PROCEDURE Program Fraud Civil Remedies and Procedures § 308.535 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Post-hearing briefs. 308.535 Section 308.535...

42 CFR 3.544 - Post hearing briefs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ORGANIZATIONS AND PATIENT SAFETY WORK PRODUCT Enforcement Program § 3.544 Post hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief... 42 Public Health 1 2010-10-01 2010-10-01 false Post hearing briefs. 3.544 Section 3.544 Public...

42 CFR 3.544 - Post hearing briefs.

Code of Federal Regulations, 2014 CFR

2014-10-01

... ORGANIZATIONS AND PATIENT SAFETY WORK PRODUCT Enforcement Program § 3.544 Post hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief... 42 Public Health 1 2014-10-01 2014-10-01 false Post hearing briefs. 3.544 Section 3.544 Public...

49 CFR 31.36 - Post-hearing briefs.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 1 2014-10-01 2014-10-01 false Post-hearing briefs. 31.36 Section 31.36 Transportation Office of the Secretary of Transportation PROGRAM FRAUD CIVIL REMEDIES § 31.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post...

38 CFR 42.36 - Post-hearing briefs.

Code of Federal Regulations, 2014 CFR

2014-07-01

...) STANDARDS IMPLEMENTING THE PROGRAM FRAUD CIVIL REMEDIES ACT § 42.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The... 38 Pensions, Bonuses, and Veterans' Relief 2 2014-07-01 2014-07-01 false Post-hearing briefs. 42...

38 CFR 42.36 - Post-hearing briefs.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) STANDARDS IMPLEMENTING THE PROGRAM FRAUD CIVIL REMEDIES ACT § 42.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The... 38 Pensions, Bonuses, and Veterans' Relief 2 2012-07-01 2012-07-01 false Post-hearing briefs. 42...

45 CFR 160.544 - Post hearing briefs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... REQUIREMENTS GENERAL ADMINISTRATIVE REQUIREMENTS Procedures for Hearings § 160.544 Post hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing... 45 Public Welfare 1 2011-10-01 2011-10-01 false Post hearing briefs. 160.544 Section 160.544...

40 CFR 27.36 - Post-hearing briefs.

Code of Federal Regulations, 2010 CFR

2010-07-01

... § 27.36 Post-hearing briefs. The presiding officer may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The presiding officer shall fix the time for... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Post-hearing briefs. 27.36 Section 27...

40 CFR 264.118 - Post-closure plan; amendment of plan.

Code of Federal Regulations, 2014 CFR

2014-07-01

... days after an unexpected event has occurred which has affected the post-closure plan. An owner or... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Post-closure plan; amendment of plan... FACILITIES Closure and Post-Closure § 264.118 Post-closure plan; amendment of plan. (a) Written Plan. The...

12 CFR 308.535 - Post-hearing briefs.

Code of Federal Regulations, 2012 CFR

2012-01-01

... PRACTICE AND PROCEDURE Program Fraud Civil Remedies and Procedures § 308.535 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing... 12 Banks and Banking 5 2012-01-01 2012-01-01 false Post-hearing briefs. 308.535 Section 308.535...

12 CFR 308.535 - Post-hearing briefs.

Code of Federal Regulations, 2014 CFR

2014-01-01

... PRACTICE AND PROCEDURE Program Fraud Civil Remedies and Procedures § 308.535 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing... 12 Banks and Banking 5 2014-01-01 2014-01-01 false Post-hearing briefs. 308.535 Section 308.535...

40 CFR 27.36 - Post-hearing briefs.

Code of Federal Regulations, 2014 CFR

2014-07-01

... § 27.36 Post-hearing briefs. The presiding officer may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The presiding officer shall fix the time for... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Post-hearing briefs. 27.36 Section 27...

49 CFR 31.36 - Post-hearing briefs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 1 2011-10-01 2011-10-01 false Post-hearing briefs. 31.36 Section 31.36 Transportation Office of the Secretary of Transportation PROGRAM FRAUD CIVIL REMEDIES § 31.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post...

45 CFR 160.544 - Post hearing briefs.

Code of Federal Regulations, 2014 CFR

2014-10-01

... REQUIREMENTS GENERAL ADMINISTRATIVE REQUIREMENTS Procedures for Hearings § 160.544 Post hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing... 45 Public Welfare 1 2014-10-01 2014-10-01 false Post hearing briefs. 160.544 Section 160.544...

42 CFR 1005.19 - Post-hearing briefs.

Code of Federal Regulations, 2014 CFR

2014-10-01

... APPEALS OF EXCLUSIONS, CIVIL MONEY PENALTIES AND ASSESSMENTS § 1005.19 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief... 42 Public Health 5 2014-10-01 2014-10-01 false Post-hearing briefs. 1005.19 Section 1005.19 Public...

49 CFR 31.36 - Post-hearing briefs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Post-hearing briefs. 31.36 Section 31.36 Transportation Office of the Secretary of Transportation PROGRAM FRAUD CIVIL REMEDIES § 31.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post...

42 CFR 1005.19 - Post-hearing briefs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... APPEALS OF EXCLUSIONS, CIVIL MONEY PENALTIES AND ASSESSMENTS § 1005.19 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief... 42 Public Health 5 2011-10-01 2011-10-01 false Post-hearing briefs. 1005.19 Section 1005.19 Public...

40 CFR 27.36 - Post-hearing briefs.

Code of Federal Regulations, 2011 CFR

2011-07-01

... § 27.36 Post-hearing briefs. The presiding officer may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The presiding officer shall fix the time for... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Post-hearing briefs. 27.36 Section 27...

12 CFR 308.535 - Post-hearing briefs.

Code of Federal Regulations, 2010 CFR

2010-01-01

... PRACTICE AND PROCEDURE Program Fraud Civil Remedies and Procedures § 308.535 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Post-hearing briefs. 308.535 Section 308.535...

42 CFR 3.544 - Post hearing briefs.

Code of Federal Regulations, 2012 CFR

2012-10-01

... ORGANIZATIONS AND PATIENT SAFETY WORK PRODUCT Enforcement Program § 3.544 Post hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief... 42 Public Health 1 2012-10-01 2012-10-01 false Post hearing briefs. 3.544 Section 3.544 Public...

45 CFR 160.544 - Post hearing briefs.

Code of Federal Regulations, 2012 CFR

2012-10-01

... REQUIREMENTS GENERAL ADMINISTRATIVE REQUIREMENTS Procedures for Hearings § 160.544 Post hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing... 45 Public Welfare 1 2012-10-01 2012-10-01 false Post hearing briefs. 160.544 Section 160.544...

40 CFR 27.36 - Post-hearing briefs.

Code of Federal Regulations, 2012 CFR

2012-07-01

... § 27.36 Post-hearing briefs. The presiding officer may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The presiding officer shall fix the time for... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Post-hearing briefs. 27.36 Section 27...

38 CFR 42.36 - Post-hearing briefs.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) STANDARDS IMPLEMENTING THE PROGRAM FRAUD CIVIL REMEDIES ACT § 42.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The... 38 Pensions, Bonuses, and Veterans' Relief 2 2013-07-01 2013-07-01 false Post-hearing briefs. 42...

42 CFR 3.544 - Post hearing briefs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... ORGANIZATIONS AND PATIENT SAFETY WORK PRODUCT Enforcement Program § 3.544 Post hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief... 42 Public Health 1 2011-10-01 2011-10-01 false Post hearing briefs. 3.544 Section 3.544 Public...

42 CFR 1005.19 - Post-hearing briefs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... APPEALS OF EXCLUSIONS, CIVIL MONEY PENALTIES AND ASSESSMENTS § 1005.19 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief... 42 Public Health 5 2010-10-01 2010-10-01 false Post-hearing briefs. 1005.19 Section 1005.19 Public...

42 CFR 1005.19 - Post-hearing briefs.

Code of Federal Regulations, 2013 CFR

2013-10-01

... APPEALS OF EXCLUSIONS, CIVIL MONEY PENALTIES AND ASSESSMENTS § 1005.19 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief... 42 Public Health 5 2013-10-01 2013-10-01 false Post-hearing briefs. 1005.19 Section 1005.19 Public...

45 CFR 160.544 - Post hearing briefs.

Code of Federal Regulations, 2013 CFR

2013-10-01

... REQUIREMENTS GENERAL ADMINISTRATIVE REQUIREMENTS Procedures for Hearings § 160.544 Post hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing... 45 Public Welfare 1 2013-10-01 2013-10-01 false Post hearing briefs. 160.544 Section 160.544...

40 CFR 264.118 - Post-closure plan; amendment of plan.

Code of Federal Regulations, 2011 CFR

2011-07-01

... days after an unexpected event has occurred which has affected the post-closure plan. An owner or... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Post-closure plan; amendment of plan... FACILITIES Closure and Post-Closure § 264.118 Post-closure plan; amendment of plan. (a) Written Plan. The...

40 CFR 27.36 - Post-hearing briefs.

Code of Federal Regulations, 2013 CFR

2013-07-01

... § 27.36 Post-hearing briefs. The presiding officer may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The presiding officer shall fix the time for... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Post-hearing briefs. 27.36 Section 27...

12 CFR 308.535 - Post-hearing briefs.

Code of Federal Regulations, 2013 CFR

2013-01-01

... PRACTICE AND PROCEDURE Program Fraud Civil Remedies and Procedures § 308.535 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing... 12 Banks and Banking 5 2013-01-01 2013-01-01 false Post-hearing briefs. 308.535 Section 308.535...

49 CFR 31.36 - Post-hearing briefs.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 1 2012-10-01 2012-10-01 false Post-hearing briefs. 31.36 Section 31.36 Transportation Office of the Secretary of Transportation PROGRAM FRAUD CIVIL REMEDIES § 31.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post...

40 CFR 264.118 - Post-closure plan; amendment of plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

... days after an unexpected event has occurred which has affected the post-closure plan. An owner or... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Post-closure plan; amendment of plan... FACILITIES Closure and Post-Closure § 264.118 Post-closure plan; amendment of plan. (a) Written Plan. The...

38 CFR 42.36 - Post-hearing briefs.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) STANDARDS IMPLEMENTING THE PROGRAM FRAUD CIVIL REMEDIES ACT § 42.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Post-hearing briefs. 42...

42 CFR 3.544 - Post hearing briefs.

Code of Federal Regulations, 2013 CFR

2013-10-01

... ORGANIZATIONS AND PATIENT SAFETY WORK PRODUCT Enforcement Program § 3.544 Post hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief... 42 Public Health 1 2013-10-01 2013-10-01 false Post hearing briefs. 3.544 Section 3.544 Public...

40 CFR 264.118 - Post-closure plan; amendment of plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

... days after an unexpected event has occurred which has affected the post-closure plan. An owner or... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Post-closure plan; amendment of plan... FACILITIES Closure and Post-Closure § 264.118 Post-closure plan; amendment of plan. (a) Written Plan. The...

45 CFR 160.544 - Post hearing briefs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... REQUIREMENTS GENERAL ADMINISTRATIVE REQUIREMENTS Procedures for Hearings § 160.544 Post hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing... 45 Public Welfare 1 2010-10-01 2010-10-01 false Post hearing briefs. 160.544 Section 160.544...

40 CFR 264.118 - Post-closure plan; amendment of plan.

Code of Federal Regulations, 2010 CFR

2010-07-01

... days after an unexpected event has occurred which has affected the post-closure plan. An owner or... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Post-closure plan; amendment of plan... FACILITIES Closure and Post-Closure § 264.118 Post-closure plan; amendment of plan. (a) Written Plan. The...

42 CFR 1005.19 - Post-hearing briefs.

Code of Federal Regulations, 2012 CFR

2012-10-01

... APPEALS OF EXCLUSIONS, CIVIL MONEY PENALTIES AND ASSESSMENTS § 1005.19 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief... 42 Public Health 5 2012-10-01 2012-10-01 false Post-hearing briefs. 1005.19 Section 1005.19 Public...

49 CFR 31.36 - Post-hearing briefs.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 1 2013-10-01 2013-10-01 false Post-hearing briefs. 31.36 Section 31.36 Transportation Office of the Secretary of Transportation PROGRAM FRAUD CIVIL REMEDIES § 31.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post...

Deep Learning of Post-Wildfire Vegetation Loss using Bitemporal Synthetic Aperture Radar Images

NASA Astrophysics Data System (ADS)

Chen, Z.; Glasscoe, M. T.; Parker, J. W.

2017-12-01

Wildfire events followed by heavy precipitation have been proven causally related to breakouts of mudflow or debris flow, which, can demand rapid evacuation and threaten residential communities and civil infrastructure. For example, in the case of the city of Glendora, California, it was first afflicted by a severe wildfire in 1968 and then the flooding caused mudslides and debris flow in 1969 killed 34 people. Therefore, burn area or vegetation loss mapping due to wildfire is critical to agencies for preparing for secondary hazards, particularly flooding and flooding induced mudflow. However, rapid post-wildfire mapping of vegetation loss mapping is not readily obtained by regular remote sensing methods, e.g. various optical methods, due to the presence of smoke, haze, and rainy/cloudy conditions that often follow a wildfire event. In this paper, we will introduce and develop a deep learning-based framework that uses Synthetic Aperture Radar images collected prior to and after a wildfire event. A convolutional neural network (CNN) approach will be used that replaces traditional principle component analysis (PCA) based differencing for non-supervised change feature extraction. Using a small sample of human-labeled burned vegetation, normal vegetation, and urban built-up pixels, we will compare the performance of deep learning and PCA-based feature extraction. The 2014 Coby Fire event, which affected the downstream city of Glendora, was used to evaluate the proposed framework. The NASA's UAVSAR data (https://uavsar.jpl.nasa.gov/) will be utilized for mapping the vegetation damage due to the Coby Fire event.

Can Rectal Diclofenac Prevent Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis?

PubMed

Lua, Guan Way; Muthukaruppan, Raman; Menon, Jayaram

2015-10-01

Non steroidal anti-inflammatory drugs (NSAIDs) have been shown to reduce the incidence of post endoscopic retrograde cholangiopancreatography pancreatitis (PEP). There were various trials using different routes and dosages of NSAIDs but meta-analysis revealed inconsistent results. The aims of this study were to determine the efficacy of rectal diclofenac in preventing PEP and to evaluate any adverse events. This was a randomized, open-label, two-arm, prospective clinical trial. Only patients at high risk of developing PEP were recruited. They received 100 mg rectal diclofenac or no intervention immediately after ERCP. The patients were reviewed 30 days after discharge to evaluate any adverse event. Among 144 recruited patients, 69 (47.9%) received diclofenac and 75 (52.1%) had no intervention. Eleven patients (7.6%) developed PEP, in which seven were from the diclofenac group and four were in the control group. Eight cases of PEP (5.5%) were mild and three cases (2.1%) were moderate. The differences in pancreatitis incidence and severity between both groups were not statistically significant. There were 11 adverse events reported. Clinically significant bleeding happened in four patients (2.8%): one from the diclofenac group and three from the control group. Other events included cholangitis: two patients (2.9%) from the diclofenac group and four (5.3%) from the control group. One patient from the diclofenac group (1.4%) had a perforation which was treated conservatively. In summary, prophylactic rectal diclofenac did not significantly decrease the incidence of PEP among patients at high risk for developing PEP. However, the administration of diclofenac was fairly safe with few clinical adverse events.

FREQUENCY OF TRAUMA EXPOSURE AND POST-TRAUMATIC STRESS DISORDERS IN ITALY: ANALYSIS FROM THE WORLD MENTAL HEALTH SURVEY INITIATIVE

PubMed Central

Carmassi, Claudia; Dell’Osso, Liliana; Manni, Corrado; Candini, Valentina; Dagani, Jessica; Iozzino, Laura; Koenen, Karestan C.; de Girolamo, Giovanni

2015-01-01

Epidemiological studies have examined the relative importance of Traumatic Events (TEs) in accounting for the societal burden of post-traumatic stress disorder (PTSD). However, most studies used the worst trauma experienced, which can lead to an overestimation of the conditional risk of PTSD. Although a number of epidemiological surveys on PTSD have been carried out in the United States, only a few studies in limited sample have been conducted in Italy. This study, carried out in the framework of the World Mental Health Survey Initiative, is a cross-sectional household survey of a representative sample of the Italian adult population. Lifetime prevalence of traumatic events (TEs) and 12-month prevalence of PTSD were evaluated using the Composite International Diagnostic Interview (CIDI). Reports of PTSD associated with randomly selected TEs were weighted by the individual-level probabilities of TE selection to generate estimates of population-level PTSD risk associated with each TE. Network events was the most commonly reported TE (29.4%). War events had the highest conditional risk of PTSD (12.2%). The TEs that contributed most to societal PTSD burden were unexpected death of a loved one (24.1%) and having seen atrocities (18.2%). Being female was related to high risk of PTSD after experiencing a TE. Exposure to network events is commonly reported among Italian adults, but two TE are responsible for the highest burden associated with PTSD: the unexpected death of someone close and sexual assault. These results can help designing public health interventions to reduce the societal PTSD burden. PMID:25266475

29 CFR 4043.32 - Transfer of benefit liabilities.

Code of Federal Regulations, 2011 CFR

2011-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.32 Transfer of benefit liabilities. (a) Reportable event—(1) In general. A reportable event occurs... notice of a reportable event under this section. Notice by any other contributing sponsor or plan...

29 CFR 4043.32 - Transfer of benefit liabilities.

Code of Federal Regulations, 2012 CFR

2012-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.32 Transfer of benefit liabilities. (a) Reportable event—(1) In general. A reportable event occurs... notice of a reportable event under this section. Notice by any other contributing sponsor or plan...

29 CFR 4043.32 - Transfer of benefit liabilities.

Code of Federal Regulations, 2014 CFR

2014-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.32 Transfer of benefit liabilities. (a) Reportable event—(1) In general. A reportable event occurs... notice of a reportable event under this section. Notice by any other contributing sponsor or plan...

29 CFR 4043.34 - Loan default.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.34 Loan default. (a) Reportable event. A reportable event occurs for a plan whenever there is a default by a member of the plan's...

29 CFR 4043.32 - Transfer of benefit liabilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.32 Transfer of benefit liabilities. (a) Reportable event—(1) In general. A reportable event occurs... notice of a reportable event under this section. Notice by any other contributing sponsor or plan...

29 CFR 4043.34 - Loan default.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.34 Loan default. (a) Reportable event. A reportable event occurs for a plan whenever there is a default by a member of the plan's...

29 CFR 4043.34 - Loan default.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.34 Loan default. (a) Reportable event. A reportable event occurs for a plan whenever there is a default by a member of the plan's...

29 CFR 4043.34 - Loan default.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.34 Loan default. (a) Reportable event. A reportable event occurs for a plan whenever there is a default by a member of the plan's...

29 CFR 4043.34 - Loan default.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.34 Loan default. (a) Reportable event. A reportable event occurs for a plan whenever there is a default by a member of the plan's...

29 CFR 4043.32 - Transfer of benefit liabilities.

Code of Federal Regulations, 2013 CFR

2013-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.32 Transfer of benefit liabilities. (a) Reportable event—(1) In general. A reportable event occurs... notice of a reportable event under this section. Notice by any other contributing sponsor or plan...

29 CFR 4043.26 - Inability to pay benefits when due.

Code of Federal Regulations, 2014 CFR

2014-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.26 Inability to pay benefits when due. (a) Reportable event. A reportable event occurs when a plan is...) Waivers. Notice is waived unless the reportable event occurs during a plan year for which the plan is...

29 CFR 4043.26 - Inability to pay benefits when due.

Code of Federal Regulations, 2012 CFR

2012-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.26 Inability to pay benefits when due. (a) Reportable event. A reportable event occurs when a plan is...) Waivers. Notice is waived unless the reportable event occurs during a plan year for which the plan is...

29 CFR 4043.26 - Inability to pay benefits when due.

Code of Federal Regulations, 2011 CFR

2011-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.26 Inability to pay benefits when due. (a) Reportable event. A reportable event occurs when a plan is...) Waivers. Notice is waived unless the reportable event occurs during a plan year for which the plan is...

29 CFR 4043.26 - Inability to pay benefits when due.

Code of Federal Regulations, 2013 CFR

2013-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.26 Inability to pay benefits when due. (a) Reportable event. A reportable event occurs when a plan is...) Waivers. Notice is waived unless the reportable event occurs during a plan year for which the plan is...

29 CFR 4043.26 - Inability to pay benefits when due.

Code of Federal Regulations, 2010 CFR

2010-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.26 Inability to pay benefits when due. (a) Reportable event. A reportable event occurs when a plan is...) Waivers. Notice is waived unless the reportable event occurs during a plan year for which the plan is...

Examining Theory-Based Behavior-Change Constructs, Social Interaction, and Sociability Features of the Weight Watchers' Online Community.

PubMed

Wang, Ye; Willis, Erin

2016-12-01

Objective To examine whether and to what extent relevant and meaningful discussions of weight loss occurred in the Weight Watchers' online community, and whether and to what extent the online community is designed for fostering such discussions. A multimethod approach was used here. First, a quantitative content analysis was conducted on 320 posts from 64 threads sampled from WeightWatchers.com's message boards between December 1, 2011, and January 31, 2012. The coding categories included constructs from the health belief model, the planned behavior theory, and the theory of self-efficacy. An acceptable level of intercoder reliability was reached; frequencies, cluster analysis, and t test were reported. Second, a conventional content analysis of the posts was conducted. The posts were examined for themes and patterns within the discussion. Finally, the researchers examined the sociability features of the message boards. The qualitative review followed established procedures and was conducted independently by four researchers. Mastery experience occurred in 46% of the posts. Threads focusing on physical activities contained more perceived barriers, mastery experiences, and verbal persuasion than other types of threads. Posts focusing on diet included unanswered questions about dieting practices with certain medical conditions. Posts focusing on mastery experience celebrated any small step toward success. Posts irrelevant to weight loss mostly contained events and happenings in members' lives. The sociability review revealed a lack of moderation. The Weight Watchers' online community included much discussion about weight loss. Findings suggest that physical activities require more encouragement than dieting. Health educators have an opportunity to interject and moderate meaningful discussions. For example, dieting with certain medical conditions, opinions on various diets, and the relationship between dieting and being healthy are opportunities to facilitate learning. Discussion posts irrelevant to weight loss help build social relationships. © 2016 Society for Public Health Education.

Transparency and the Food and Drug Administration--a quantitative study.

PubMed

Lofstedt, Ragnar; Bouder, Frederic; Chakraborty, Sweta

2013-01-01

In Europe and North America, there is increasing political pressure being put on health regulatory agencies to become more transparent. To date, however, there has been little academic evaluation--let alone analysis--of these transparency initiatives from a risk communication perspective. This review examines whether the U.S. Food and Drug Administration's Adverse Event Reporting System quarterly signal postings, put in place after the passage of the Food and Drug Administration Amendments Act 2007, will assist patients and doctors in their decision-making processes, on the basis of results of a quantitative Internet survey of 433 physicians and 1,000 American adults. The results indicate that there is significant disagreement between physicians and the public about when medical safety issues should be communicated in the first place, with physicians opposed to early signal postings while the public in general is in favor. In addition the findings show that if the public were to find their drugs listed on the Adverse Event Reporting System signals web postings, more than a quarter would stop taking their medicine. Going forward, the Food and Drug Administration needs to work to a greater degree with social scientists in developing scientific-based communication strategies, rather than developing transparency initiatives on the basis of stakeholder consultations.

The Effect of Sex and Anthropometry on Clinical Outcomes in Patients Undergoing Percutaneous Coronary Intervention for Complex Coronary Lesions.

PubMed

Lee, Seung Yul; Shin, Dong Ho; Kim, Jung Sun; Kim, Byeong Keuk; Ko, Young Guk; Choi, Donghoon; Jang, Yangsoo; Hong, Myeong Ki

2017-03-01

To evaluate the effects of sex and anthropometry on clinical outcomes in patients who underwent percutaneous coronary intervention (PCI). From three randomized trials (REal Safety and Efficacy of 3-month dual antiplatelet Therapy following Endeavor zotarolimus-eluting stent implantation, Impact of intraVascular UltraSound guidance on outcomes of Xience Prime stents in Long lesions, Chronic Total Occlusion InterVention with drUg-eluting Stents), we compared 333 pairs of men and women matched by propensity scores, all of whom underwent intravascular ultrasound (IVUS)-guided PCI for complex lesions. For 12 months, the incidence of adverse cardiac events, defined as the composite of cardiac death, target lesion-related myocardial infarction, and target lesion revascularization, was not different between women and men (2.4% vs. 2.4%, p=0.939). Using multivariable Cox's regression analysis, post-intervention minimum lumen area [MLA; hazard ratio (HR)=0.620, 95% confidence interval (CI)=0.423-0.909, p=0.014] by IVUS was a predictor of adverse cardiac events. Height on anthropometry and lesions with chronic total occlusion were significantly related to post-intervention MLA. However, female sex was not independently associated with post-intervention MLA. In an age and sex-adjusted model, patients in the low tertile of height exhibited a greater risk for adverse cardiac events than those in the high tertile of height (HR=6.391, 95% CI=1.160-35.206, p=0.033). Sex does not affect clinical outcomes after PCI for complex lesions. PCI outcomes, however, may be adversely affected by height.

Water intake and post-exercise cognitive performance: an observational study of long-distance walkers and runners.

PubMed

Benefer, Martin D; Corfe, Bernard M; Russell, Jean M; Short, Richard; Barker, Margo E

2013-03-01

The impact of diet on endurance performance and cognitive function has been extensively researched in controlled settings, but there are limited observational data in field situations. This study examines relationships between nutrient intake and cognitive function following endurance exercise amongst a group of 33 recreational runners and walkers. All participants (mean age of 43.2 years) took part in a long-distance walking event and completed diet diaries to estimate nutrient intake across three-time periods (previous day, breakfast and during the event). Anthropometric measurements were recorded. Cognitive tests, covering word recall, ruler drop and trail making tests (TMT) A and B were conducted pre- and post-exercise. Participants rated their exercise level on a validated scale. Nutrient intake data were summarised using principal components analysis to identify a nutrient intake pattern loaded towards water intake across all time periods. Regression analysis was used to ascertain relationships between water intake component scores and post-exercise cognitive function, controlling for anthropometric measures and exercise metrics (distance, duration and pace). Participants rated their exercise as 'hard-heavy' (score 14.4, ±3.2). Scores on the water intake factor were associated with significantly faster TMT A (p = 0.001) and TMT B (p = 0.005) completion times, and a tendency for improved short-term memory (p = 0.090). Water intake scores were not associated with simple reaction time (assessed via the ruler drop test). These data are congruent with experimental research demonstrating a benefit of hydration on cognitive function. Further field research to confirm this relationship, supported with precise measures of body weight, is needed.

[Violence and post-traumatic stress disorder in childhood].

PubMed

Ximenes, Liana Furtado; de Oliveira, Raquel de Vasconcelos Carvalhães; de Assis, Simone Gonçalves

2009-01-01

This study presents the prevalence of symptoms of Posttraumatic Stress Disorder (PTSD) in 500 schoolchildren (6-13 years old) in São Gonçalo, Rio de Janeiro. It also investigates the association between PTSD, violence and other adverse events in the lives of these children. The multi-stage cluster sampling strategy involved three selection stages. Parents were interviewed about their children's behavior. The instrument used to screen symptoms of PTSD was the Child Behavior Checklist-Posttraumatic Stress Disorder Scale (CBCL-PTSD). Conflict Tactics Scales (CTS) were applied to evaluate family violence and other scales to investigate the socioeconomic profile, familiar relationship, characteristics and adverse events in the lives of the children. Multivariate analysis was performed using a hierarchical model with a significance level of 5%. The prevalence of clinical symptoms of PTSD was of 6.5%. The multivariate analysis suggested an explanation model of PTSD characterized by 18 variables, such as the child's characteristics; specific life events; family violence; and other family factors. The results reveal that it is necessary to work with the child in particularly difficult moments of his/her life in order to prevent or minimize the impact of adverse events on their mental and social functioning.

Differing Oxygen Concentrations and the Effect on Post-Hypoxia Recovery

DTIC Science & Technology

Given the consistent rise in hypoxia-like in-flight emergencies and the negative effects of hypoxia on human performance , it is important to garner a...tracking task and regional oxygen saturation of the frontal lobes of the brain during a hypoxic event and to document differences in performance recovery...measures analysis of variance revealed no significant differences between the speeds at which participants recovered from hypoxic exposure, regardless of

An Analysis of the Understanding of Geological Time by Students at Secondary and Post-Secondary Level. Research Report

ERIC Educational Resources Information Center

Hidalgo, Antonio J.; Otero, Jose

2004-01-01

This paper addresses the concept of geological time as used by students who face tasks that demand three types of skills: to locate events in time, to order them according to time calendar, and to manage time intervals. The empirical study consisted of asking high school students as well as technical school students to carry out tasks that…

Comparative Analysis of THOR-NT ATD vs. Hybrid III ATD in Laboratory Vertical Shock Testing

DTIC Science & Technology

2013-09-01

were taken both pretest and post - test for each test event (figure 5). Figure 5. Rigid fixture placed on the drop table with ATD seated: Hybrid III...6 3. Experimental Procedure 6 3.1 Test Setup...frames per second and with a Vision Research Phantom V9.1 (Wayne, NJ) high-speed video camera, sampling 1000 frames per second. 3. Experimental

An Implementation Analysis of Threat Assessment Policies in Public Universities and Community Colleges in Central Texas: A Post Virginia Tech Incident Assessment

ERIC Educational Resources Information Center

Piet DeLaTorre, Christine

2011-01-01

It is clear that the tragic events at Virginia Tech and other institutions of higher education (IHEs) have brought threat assessment to the forefront of higher education literature and increased public concern for campus safety. IHEs have a profound duty to learn from the Virginia Tech tragedy and to recognize their responsibility in providing a…

Nuclear Dynamics Consequence Analysis (NDCA) for the Disposal of Spent Nuclear Fuel in an Underground Geologic Repository--Volume 2: Methodology and Results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Taylor, L.L.; Wilson, J.R.; Sanchez, L.C.

1998-10-01

The US Department of Energy Office of Environmental Management's (DOE/EM's) National Spent Nuclear Fuel Program (NSNFP), through a collaboration between Sandia National Laboratories (SNL) and Idaho National Engineering and Environmental Laboratory (INEEL), is conducting a systematic Nuclear Dynamics Consequence Analysis (NDCA) of the disposal of SNFs in an underground geologic repository sited in unsaturated tuff. This analysis is intended to provide interim guidance to the DOE for the management of the SNF while they prepare for final compliance evaluation. This report presents results from a Nuclear Dynamics Consequence Analysis (NDCA) that examined the potential consequences and risks of criticality duringmore » the long-term disposal of spent nuclear fuel owned by DOE-EM. This analysis investigated the potential of post-closure criticality, the consequences of a criticality excursion, and the probability frequency for post-closure criticality. The results of the NDCA are intended to provide the DOE-EM with a technical basis for measuring risk which can be used for screening arguments to eliminate post-closure criticality FEPs (features, events and processes) from consideration in the compliance assessment because of either low probability or low consequences. This report is composed of an executive summary (Volume 1), the methodology and results of the NDCA (Volume 2), and the applicable appendices (Volume 3).« less

Coseismic Compression/Dilatation and Viscoelastic Uplift/Subsidence Following the 2012 Indian Ocean Earthquakes Quantified from Satellite Gravity Observations

NASA Technical Reports Server (NTRS)

Han, Shin-Chan; Sauber, Jeanne; Pollitz, Fred

2015-01-01

The 2012 Indian Ocean earthquake sequence (M(sub w) 8.6, 8.2) is a rare example of great strike slip earthquakes in an intra-oceanic setting. With over a decade of GRACE data, we were able to measure and model the unanticipated large co-, and post-seismic gravity changes of these events. Using the approach of normal mode decomposition and spatial localization, we computed the gravity changes corresponding to five moment tensor components. Our analysis revealed that the gravity changes are produced predominantly by coseismic compression and dilatation within the oceanic crust and upper mantle and by post-seismic vertical motion. Our results suggest that the post-seismic positive gravity and the post-seismic uplift measured with GPS within the coseismic compressional quadrant are best fit by ongoing uplift associated with viscoelastic mantle relaxation. Our study demonstrates that the GRACE data are suitable for analyzing strike-slip earthquakes as small as M(sub w) 8.2 with the noise characteristics of this region.

Stress-Induced Fracturing of Reservoir Rocks: Acoustic Monitoring and μCT Image Analysis

NASA Astrophysics Data System (ADS)

Pradhan, Srutarshi; Stroisz, Anna M.; Fjær, Erling; Stenebråten, Jørn F.; Lund, Hans K.; Sønstebø, Eyvind F.

2015-11-01

Stress-induced fracturing in reservoir rocks is an important issue for the petroleum industry. While productivity can be enhanced by a controlled fracturing operation, it can trigger borehole instability problems by reactivating existing fractures/faults in a reservoir. However, safe fracturing can improve the quality of operations during CO2 storage, geothermal installation and gas production at and from the reservoir rocks. Therefore, understanding the fracturing behavior of different types of reservoir rocks is a basic need for planning field operations toward these activities. In our study, stress-induced fracturing of rock samples has been monitored by acoustic emission (AE) and post-experiment computer tomography (CT) scans. We have used hollow cylinder cores of sandstones and chalks, which are representatives of reservoir rocks. The fracture-triggering stress has been measured for different rocks and compared with theoretical estimates. The population of AE events shows the location of main fracture arms which is in a good agreement with post-test CT image analysis, and the fracture patterns inside the samples are visualized through 3D image reconstructions. The amplitudes and energies of acoustic events clearly indicate initiation and propagation of the main fractures. Time evolution of the radial strain measured in the fracturing tests will later be compared to model predictions of fracture size.

Developmental effects of tobacco smoke exposure during human embryonic stem cell differentiation are mediated through the transforming growth factor-β superfamily member, Nodal

PubMed Central

Liszewski, Walter; Ritner, Carissa; Aurigui, Julian; Wong, Sharon S. Y.; Hussain, Naveed; Krueger, Winfried; Oncken, Cheryl; Bernstein, Harold S.

2012-01-01

While the pathologies associated with in utero smoke exposure are well established, their underlying molecular mechanisms are incompletely understood. We differentiated human embryonic stem cells in the presence of physiological concentrations of tobacco smoke and nicotine. Using post hoc microarray analysis, quantitative PCR, and immunoblot analysis, we demonstrated that tobacco smoke has lineage- and stage-specific effects on human embryonic stem cell differentiation, through both nicotine-dependent and -independent pathways. We show that three major stem cell pluripotency/differentiation pathways, Notch, canonical Wnt, and transforming growth factor-β, are affected by smoke exposure, and that Nodal signaling through SMAD2 is specifically impacted by effects on Lefty1, Nodal, and FoxH1. These events are associated with upregulation of microRNA-302a, a post-transcriptional silencer of Lefty1. The described studies provide insight into the mechanisms by which tobacco smoke influences fetal development at the cellular level, and identify specific transcriptional, post-transcriptional, and signaling pathways by which this likely occurs. PMID:22381624

Rapid Landslide Mapping by Means of Post-Event Polarimetric SAR Imagery

NASA Astrophysics Data System (ADS)

Plank, Simon; Martinis, Sandro; Twele, Andre

2016-08-01

Rapid mapping of landslides, quickly providing information about the extent of the affected area and type and grade of damage, is crucial to enable fast crisis response. Reviewing the literature shows that most synthetic aperture radar (SAR) data-based landslide mapping procedures use change detection techniques. However, the required very high resolution (VHR) pre-event SAR imagery, acquired shortly before the landslide event, is commonly not available. Due to limitations in onboard disk space and downlink transmission rates modern VHR SAR missions do not systematically cover the entire world. We present a fast and robust procedure for mapping of landslides, based on change detection between freely available and systematically acquired pre-event optical and post-event polarimetric SAR data.

29 CFR 4043.25 - Failure to make required minimum funding payment.

Code of Federal Regulations, 2013 CFR

2013-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.25 Failure to make required minimum funding payment. (a) Reportable event. A reportable event occurs when a required installment or a payment required under section 302 of ERISA or section 412...

29 CFR 4043.25 - Failure to make required minimum funding payment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.25 Failure to make required minimum funding payment. (a) Reportable event. A reportable event occurs when a required installment or a payment required under section 302 of ERISA or section 412...

29 CFR 4043.25 - Failure to make required minimum funding payment.

Code of Federal Regulations, 2012 CFR

2012-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.25 Failure to make required minimum funding payment. (a) Reportable event. A reportable event occurs when a required installment or a payment required under section 302 of ERISA or section 412...

29 CFR 4043.25 - Failure to make required minimum funding payment.

Code of Federal Regulations, 2011 CFR

2011-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.25 Failure to make required minimum funding payment. (a) Reportable event. A reportable event occurs when a required installment or a payment required under section 302 of ERISA or section 412...

Acoustic emission from trabecular bone during mechanical testing: the effect of osteoporosis and osteoarthritis.

PubMed

Leichter, I; Bivas, A; Margulies, J Y; Roman, I; Simkin, A

1990-01-01

This study examines the relation between the nature of acoustic emission signals emitted from cancellous bone under compression and the mechanical properties of the tissue. The examined bone specimens were taken from 12 normal, 31 osteoporotic and six osteoarthritic femoral heads. The mechanical behaviour of the osteoporotic bone specimens was found to be significantly different from that of the normal specimens both in the pre-yield and post-yield ranges. In the osteoarthritic bones only the elastic behaviour was significantly different. The rates of acoustic events before yield and beyond it were found to be significantly higher both in the osteoporotic and osteoarthritic bone specimens. The average peak amplitude of the signals was also significantly higher in the diseased bones. Stepwise regression analysis showed that a combination of the acoustic emission parameters could significantly predict some mechanical properties of the bone. The energy absorbed during compression and the ultimate compressive stress of the specimens could be estimated from the rate of pre-yield acoustic events, the average amplitude of the signals and the rate of post-yield events. However, the explanation power of the acoustic emission parameters was only moderate. The nature of acoustic emission signals was thus demonstrated to be a potential tool for assessing bone quality.

Logistic Regression Likelihood Ratio Test Analysis for Detecting Signals of Adverse Events in Post-market Safety Surveillance.

PubMed

Nam, Kijoeng; Henderson, Nicholas C; Rohan, Patricia; Woo, Emily Jane; Russek-Cohen, Estelle

2017-01-01

The Vaccine Adverse Event Reporting System (VAERS) and other product surveillance systems compile reports of product-associated adverse events (AEs), and these reports may include a wide range of information including age, gender, and concomitant vaccines. Controlling for possible confounding variables such as these is an important task when utilizing surveillance systems to monitor post-market product safety. A common method for handling possible confounders is to compare observed product-AE combinations with adjusted baseline frequencies where the adjustments are made by stratifying on observable characteristics. Though approaches such as these have proven to be useful, in this article we propose a more flexible logistic regression approach which allows for covariates of all types rather than relying solely on stratification. Indeed, a main advantage of our approach is that the general regression framework provides flexibility to incorporate additional information such as demographic factors and concomitant vaccines. As part of our covariate-adjusted method, we outline a procedure for signal detection that accounts for multiple comparisons and controls the overall Type 1 error rate. To demonstrate the effectiveness of our approach, we illustrate our method with an example involving febrile convulsion, and we further evaluate its performance in a series of simulation studies.

Unsupervised Approaches for Post-Processing in Computationally Efficient Waveform-Similarity-Based Earthquake Detection

NASA Astrophysics Data System (ADS)

Bergen, K.; Yoon, C. E.; OReilly, O. J.; Beroza, G. C.

2015-12-01

Recent improvements in computational efficiency for waveform correlation-based detections achieved by new methods such as Fingerprint and Similarity Thresholding (FAST) promise to allow large-scale blind search for similar waveforms in long-duration continuous seismic data. Waveform similarity search applied to datasets of months to years of continuous seismic data will identify significantly more events than traditional detection methods. With the anticipated increase in number of detections and associated increase in false positives, manual inspection of the detection results will become infeasible. This motivates the need for new approaches to process the output of similarity-based detection. We explore data mining techniques for improved detection post-processing. We approach this by considering similarity-detector output as a sparse similarity graph with candidate events as vertices and similarities as weighted edges. Image processing techniques are leveraged to define candidate events and combine results individually processed at multiple stations. Clustering and graph analysis methods are used to identify groups of similar waveforms and assign a confidence score to candidate detections. Anomaly detection and classification are applied to waveform data for additional false detection removal. A comparison of methods will be presented and their performance will be demonstrated on a suspected induced and non-induced earthquake sequence.

Posttraumatic stress disorder after myocardial infarction and coronary artery bypass grafting.

PubMed

Singh, Amitoj; Agrawal, Sahil; Gargya, Sanchita; Saluja, Sabir; Kumar, Akshat; Kumar, Abhishek; Kalra, Kartik; Thind, Munveer; Saluja, Sajeev; Stone, Lauren E; Ali, Farhan; Duarte-Chavez, Rodrigo; Marchionni, Christine; Sholevar, Farhad; Shirani, Jamshid; Nanda, Sudip

2017-01-01

Post traumatic stress disorder is a psychiatric disease that is usually precipitated by life threatening stressors. Myocardial infarction, especially in the young can count as one such event. The development of post traumatic stress after a coronary event not only adversely effects psychiatric health, but leads to increased cardiovascular morbidity and mortality. There is increasing evidence that like major depression, post traumatic stress disorder is also a strong coronary risk factor. Early diagnosis and treatment of this disease in patients with acute manifestations of coronary artery disease can improve patient outcomes.

Synovial osteochondromatosis involvement in post-traumatic ankle injury.

PubMed

Lee, Daniel K; Louk, Louis; Bell, Bryan L

2008-01-01

Ankle involvement by synovial chondromatosis is unusual. It is unknown whether a post-traumatic event to the ankle induces the formation and development of these lesions. Synovial osteochondromatosis associated with post-traumatic ankle events are rare but suggest trauma to the synovial tissues as being causative, although this has never been statistically confirmed owing to the lack of reports and frequency. We report a case of primary synovial osteochondromatosis involving the tibiotalar joint with painful symptoms after a history of ankle injury, including magnetic resonance imaging findings of this unusual condition.

The effect of intensive glucose lowering therapy among major racial/ethnic groups in the Veterans Affairs Diabetes Trial

PubMed Central

Saremi, Aramesh; Schwenke, Dawn C.; Bahn, Gideon; Ge, Ling; Emanuele, Nicholas; Reaven, Peter D.

2014-01-01

Objective To examine the effect of intensive glycemic control on cardiovascular disease events (CVD) among the major race/ethnic groups in a post-hoc analysis of the VADT. Materials and Methods Participants included 1111 non-Hispanic Whites, 307 Hispanics and 306 non-Hispanic Blacks randomized to intensive or standard glucose treatment in VADT. Multivariable Cox proportional hazards models were constructed to assess the effect of intensive glucose treatment on CVD events among race/ethnic groups. Results Mean age was 60.4 years and median follow-up was 5.6 years. By design, modifiable risk factors were managed equally well in both treatment arms and only differed modestly between race/ethnic groups. HbA1c decreased significantly from baseline with intensive glucose treatment in each race/ethnic group, with a trend for a greater response in Hispanics (P=0.02 for overall comparison between groups). Intensive glucose treatment was associated with reduced risk of CVD events for Hispanics but not for others (hazard ratios ranged from 0.54 to 0.75 for Hispanics whereas they were consistently close to 1 for others). Sensitivity analyses with different definitions of race/ethnicity or limited to individuals free of previous known CVD yielded similar results. Conclusions The results of these analyses support the hypothesis that race/ethnicity is worthy of consideration when tailoring intensive treatment for individuals with long-standing type 2 diabetes. However, additional studies are needed to confirm the findings of this post-hoc analysis. PMID:25456099

Efficacy and safety of rotigotine in elderly patients with Parkinson's disease in comparison with the non-elderly: a post hoc analysis of randomized, double-blind, placebo-controlled trials.

PubMed

Nomoto, Masahiro; Iwaki, Hirotaka; Kondo, Hiroyuki; Sakurai, Masaya

2018-02-01

Rotigotine-a non-ergot dopamine agonist-has two advantages; it can stimulate all dopamine receptors (D1-D5) like innate dopamine, and its transdermal administration provides continuous dopaminergic stimulation. The age of the patient impacts the effect and adverse events of anti-parkinsonian treatment. We conducted a post hoc analysis on three randomized, double-blind, placebo-controlled trials performed in Japan to clarify the difference of anti-parkinsonian treatment in elderly and non-elderly patients. Data from two combination therapy trials (with levodopa) in advanced stage Parkinson's disease patients and one monotherapy trial in early stage patients were pooled and grouped by age (non-elderly aged < 70, elderly aged 70 +). In each age group, efficacy of rotigotine was compared to placebo. In the combination therapy, total Unified Parkinson's Disease Rating Scale Part III scores and some subtotal scores, including those for tremor, akinesia and gait disturbance, significantly improved in both elderly and non-elderly patients. Regarding safety, the incidence of total adverse event tended to be lower in elderly patients than non-elderly patients, although it was not significant. No difference was observed in maintenance dosage of rotigotine between the two groups. In conclusion, the improvement in motor symptoms and frequency of adverse events were shown to be similar in elderly and non-elderly patients with rotigotine-levodopa combination therapy. Further, there was no major difference in maintenance dosage of rotigotine between the age groups. These results suggest good tolerability of rotigotine among elderly patients.

Alpine thermal events in the central Serbo-Macedonian Massif (southeastern Serbia)

NASA Astrophysics Data System (ADS)

Antić, Milorad D.; Kounov, Alexandre; Trivić, Branislav; Wetzel, Andreas; Peytcheva, Irena; von Quadt, Albrecht

2016-07-01

The Serbo-Macedonian Massif (SMM) represents a crystalline belt situated between the two diverging branches of the Eastern Mediterranean Alpine orogenic system, the northeast-vergent Carpatho-Balkanides and the southwest-vergent Dinarides and the Hellenides. We have applied fission-track analysis on apatites and zircons, coupled with structural field observations in order to reveal the low-temperature evolution of the SMM. Additionally, the age and geochemistry of the Palaeogene igneous rocks (i.e. Surdulica granodiorite and dacitic volcanic rocks) were determined by the LA-ICPMS U-Pb geochronology of zircons and geochemical analysis of main and trace elements in whole-rock samples. Three major cooling stages have been distinguished from the late Early Cretaceous to the Oligocene. The first stage represents rapid cooling through the partial annealing zones of zircon and apatite (300-60 °C) during the late Early to early Late Cretaceous (ca. 110-ca. 90 Ma). It is related to a post-orogenic extension following the regional nappe-stacking event in the Early Cretaceous. Middle to late Eocene (ca. 48-ca. 39 Ma) cooling is related to the formation of the Crnook-Osogovo-Lisets extensional dome and its exhumation along low-angle normal faults. The third event is related to regional cooling following the late Eocene magmatic pulse. During this pulse, the areas surrounding the Surdulica granodiorite (36 ± 1 Ma) and the slightly younger volcanic bodies (ca. 35 Ma) have reached temperatures higher than the apatite closure temperature (120 °C) but lower than ca. 250 °C. The geochemistry of the igneous samples reveals late- to post-orogenic tectonic setting during magma generation.

Isolation of Cardiomyocyte Nuclei from Post-mortem Tissue

PubMed Central

Bergmann, Olaf; Jovinge, Stefan

2012-01-01

Identification of cardiomyocyte nuclei has been challenging in tissue sections as most strategies rely only on cytoplasmic marker proteins1. Rare events in cardiac myocytes such as proliferation and apoptosis require an accurate identification of cardiac myocyte nuclei to analyze cellular renewal in homeostasis and in pathological conditions2. Here, we provide a method to isolate cardiomyocyte nuclei from post mortem tissue by density sedimentation and immunolabeling with antibodies against pericentriolar material 1 (PCM-1) and subsequent flow cytometry sorting. This strategy allows a high throughput analysis and isolation with the advantage of working equally well on fresh tissue and frozen archival material. This makes it possible to study material already collected in biobanks. This technique is applicable and tested in a wide range of species and suitable for multiple downstream applications such as carbon-14 dating3, cell-cycle analysis4, visualization of thymidine analogues (e.g. BrdU and IdU)4, transcriptome and epigenetic analysis. PMID:22805241

Dosimetric Predictors of Symptomatic Cardiac Events after Conventional-Dose Chemoradiation Therapy for Inoperable Non-Small Cell Lung Cancer.

PubMed

Yegya-Raman, Nikhil; Wang, Kyle; Kim, Sinae; Reyhan, Meral; Deek, Matthew P; Sayan, Mutlay; Li, Diana; Patel, Malini; Malhotra, Jyoti; Aisner, Joseph; Marks, Lawrence B; Jabbour, Salma K

2018-06-05

We hypothesized that higher cardiac doses correlates with clinically significant cardiotoxicity after standard-dose chemoradiation therapy (CRT) (∼60 Gy) for inoperable non-small cell lung cancer (NSCLC). We retrospectively reviewed the records of 140 patients with inoperable NSCLC treated with concurrent CRT from 2007-2015. Extracted data included baseline cardiac status, dosimetric parameters to the whole heart (WH) and cardiac substructures, and the development of post-CRT symptomatic cardiac events (acute coronary syndrome [ACS], arrhythmia, pericardial effusion, pericarditis, and congestive heart failure [CHF]). Competing risks analysis was used to estimate time to cardiac events. Median follow-up was 47.4 months. Median radiation therapy dose was 61.2 Gy (interquartile range, 60-66 Gy). Forty patients (28.6%) developed 47 symptomatic cardiac events at a median of 15.3 months to first event. On multivariate analysis, higher WH doses and baseline cardiac status were associated with an increased risk of symptomatic cardiac events. The 4-year cumulative incidence of symptomatic cardiac events was 48.6% versus 18.5% for mean WH dose ≥ 20 Gy versus < 20 Gy, respectively (p = 0.0002). Doses to the WH, ventricles, and left anterior descending artery were associated with ACS/CHF, whereas doses to the WH and atria were not associated with supraventricular arrhythmias. Symptomatic cardiac events (p = 0.0001) were independently associated with death. Incidental cardiac irradiation was associated with subsequent symptomatic cardiac events, particularly ACS/CHF, and symptomatic cardiac events were associated with inferior survival. These results support the minimization of cardiac doses among patients with inoperable NSCLC receiving standard-dose CRT. Copyright © 2018 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

Acrolein Exposure in Hookah Smokers and Non-Smokers Exposed to Hookah Tobacco Secondhand Smoke: Implications for Regulating Hookah Tobacco Products.

PubMed

Kassem, Nada O F; Kassem, Noura O; Liles, Sandy; Zarth, Adam T; Jackson, Sheila R; Daffa, Reem M; Chatfield, Dale A; Carmella, Steven G; Hecht, Stephen S; Hovell, Melbourne F

2018-03-06

Acrolein is a highly ciliatoxic agent, a toxic respiratory irritant, a cardiotoxicant, and a possible carcinogen present in tobacco smoke including hookah tobacco. 105 hookah smokers and 103 non-smokers attended exclusively hookah smoking social events at either a hookah lounge or private home, and provided urine samples the morning of and the morning after the event. Samples were analyzed for 3-hydroxypropylmercapturic acid (3-HPMA), a metabolite of acrolein. Geometric mean (GM) urinary 3-HPMA levels in hookah smokers and non-smokers exposed to secondhand smoke (SHS) increased significantly, 1.41 times, 95% CI = 1.15 to 1.74 and 1.39 times, 95% CI = 1.16 to 1.67, respectively, following a hookah social event. The highest increase (1.68 times, 95% CI = 1.15 to 2.45; p = 0.007) in 3-HPMA post a hookah social event was among daily hookah smokers (GM, from 1991 pmol/mg to 3348 pmol/mg). Pre-to-post event change in urinary 3-HPMA was significantly positively correlated with pre-to-post event change in urinary cotinine among hookah smokers at either location of hookah event, (ρ = 0.359, p = 0.001), and among non-smokers in hookah lounges (ρ = 0.369, p = 0.012). Hookah tobacco smoke is a source of acrolein exposure. Findings support regulating hookah tobacco products including reducing humectants and sugar additives, which are precursors of acrolein under certain pyrolysis conditions. We suggest posting health warning signs for indoor smoking in hookah lounges, and encouraging voluntary bans of smoking hookah tobacco in private homes. Our study is the first to quantify the increase in acrolein exposure in hookah smokers and non-smokers exposed to exclusively hookah tobacco SHS at hookah social events in homes or hookah lounges. Our findings provide additional support for regulating hookah tobacco product content, protecting non-smokers' health by posting health warning signs for indoor smoking in hookah lounges, and encouraging home bans on hookah tobacco smoking to safeguard vulnerable residents.

Post-Coma Persons with Extensive Multiple Disabilities Use Microswitch Technology to Access Selected Stimulus Events or Operate a Radio Device

ERIC Educational Resources Information Center

Lancioni, Giulio E.; Singh, Nirbhay N.; O'Reilly, Mark F.; Sigafoos, Jeff; Alberti, Gloria; Oliva, Doretta; Megna, Gianfranco; Iliceto, Carla; Damiani, Sabino; Ricci, Irene; Spica, Antonella

2011-01-01

The present two studies extended research evidence on the use of microswitch technology by post-coma persons with multiple disabilities. Specifically, Study I examined whether three adults with a diagnosis of minimally conscious state and multiple disabilities could use microswitches as tools to access brief, selected stimulus events. Study II…

75 FR 34700 - Taking and Importing Marine Mammals; Taking Marine Mammals Incidental to Coastal Commercial...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-18

... conducted post-event monitoring to record the presence of injured or dead marine mammals, and other wildlife... present at the site and a post-event census on July 5 found no injured or dead marine mammals. On July 3... or dead marine mammals. In summary, MBNMS conducted activities as described in the regulations...

The relationship of post-event processing to self-evaluation of performance in social anxiety.

PubMed

Brozovich, Faith; Heimberg, Richard G

2011-06-01

Socially anxious and control participants engaged in a social interaction with a confederate and then wrote about themselves or the other person (i.e., self-focused post-event processing [SF-PEP] vs. other-focused post-event processing [OF-PEP]) and completed several questionnaires. One week later, participants completed measures concerning their evaluation of their performance in the social interaction and the degree to which they engaged in post-event processing (PEP) during the week. Socially anxious individuals evaluated their performance in the social interaction more poorly than control participants, both immediately after and 1 week later. Socially anxious individuals assigned to the SF-PEP condition displayed fewer positive feelings about their performance compared to the socially anxious individuals in the OF-PEP condition as well as controls in either condition. Also, the trait tendency to engage in PEP moderated the effect of social anxiety on participants' evaluation of their performance in the interaction, such that high socially anxious individuals with high trait PEP scores evaluated themselves in the interaction more negatively at the later assessment. These results suggest that PEP and other self-evaluative processes may perpetuate the cycle of social anxiety. Copyright © 2011. Published by Elsevier Ltd.

Point Cloud Based Change Detection - an Automated Approach for Cloud-based Services

NASA Astrophysics Data System (ADS)

Collins, Patrick; Bahr, Thomas

2016-04-01

The fusion of stereo photogrammetric point clouds with LiDAR data or terrain information derived from SAR interferometry has a significant potential for 3D topographic change detection. In the present case study latest point cloud generation and analysis capabilities are used to examine a landslide that occurred in the village of Malin in Maharashtra, India, on 30 July 2014, and affected an area of ca. 44.000 m2. It focuses on Pléiades high resolution satellite imagery and the Airbus DS WorldDEMTM as a product of the TanDEM-X mission. This case study was performed using the COTS software package ENVI 5.3. Integration of custom processes and automation is supported by IDL (Interactive Data Language). Thus, ENVI analytics is running via the object-oriented and IDL-based ENVITask API. The pre-event topography is represented by the WorldDEMTM product, delivered with a raster of 12 m x 12 m and based on the EGM2008 geoid (called pre-DEM). For the post-event situation a Pléiades 1B stereo image pair of the AOI affected was obtained. The ENVITask "GeneratePointCloudsByDenseImageMatching" was implemented to extract passive point clouds in LAS format from the panchromatic stereo datasets: • A dense image-matching algorithm is used to identify corresponding points in the two images. • A block adjustment is applied to refine the 3D coordinates that describe the scene geometry. • Additionally, the WorldDEMTM was input to constrain the range of heights in the matching area, and subsequently the length of the epipolar line. The "PointCloudFeatureExtraction" task was executed to generate the post-event digital surface model from the photogrammetric point clouds (called post-DEM). Post-processing consisted of the following steps: • Adding the geoid component (EGM 2008) to the post-DEM. • Pre-DEM reprojection to the UTM Zone 43N (WGS-84) coordinate system and resizing. • Subtraction of the pre-DEM from the post-DEM. • Filtering and threshold based classification of the DEM difference to analyze the surface changes in 3D. The automated point cloud generation and analysis introduced here can be embedded in virtually any existing geospatial workflow for operational applications. Three integration options were implemented in this case study: • Integration within any ArcGIS environment whether deployed on the desktop, in the cloud, or online. Execution uses a customized ArcGIS script tool. A Python script file retrieves the parameters from the user interface and runs the precompiled IDL code. That IDL code is used to interface between the Python script and the relevant ENVITasks. • Publishing the point cloud processing tasks as services via the ENVI Services Engine (ESE). ESE is a cloud-based image analysis solution to publish and deploy advanced ENVI image and data analytics to existing enterprise infrastructures. For this purpose the entire IDL code can be capsuled in a single ENVITask. • Integration in an existing geospatial workflow using the Python-to-IDL Bridge. This mechanism allows calling IDL code within Python on a user-defined platform. The results of this case study allow a 3D estimation of the topographic changes within the tectonically active and anthropogenically invaded Malin area after the landslide event. Accordingly, the point cloud analysis was correlated successfully with modelled displacement contours of the slope. Based on optical satellite imagery, such point clouds of high precision and density distribution can be obtained in a few minutes to support the operational monitoring of landslide processes.

Confronting Undesirable Traditions: A Case Study.

ERIC Educational Resources Information Center

Clement, Linda M.

2002-01-01

The necessity of extensive planning for major campus events has become essential to ensure a safe environment for all participants. This article explores the way one campus is challenging negative major event behaviors from pre-event preparations to post-event celebrations. (Contains 17 references.) (Author)

43 CFR 35.36 - Post-hearing briefs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... CLAIMS AND STATEMENTS § 35.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Post-hearing briefs. 35.36 Section 35.36...

20 CFR 355.36 - Post-hearing briefs.

Code of Federal Regulations, 2014 CFR

2014-04-01

... REGULATIONS UNDER THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 355.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true Post-hearing briefs. 355.36 Section 355.36...

28 CFR 71.36 - Post-hearing briefs.

Code of Federal Regulations, 2014 CFR

2014-07-01

....36 Post-hearing briefs. ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such briefs, not to exceed 60... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Post-hearing briefs. 71.36 Section 71.36...

43 CFR 35.36 - Post-hearing briefs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CLAIMS AND STATEMENTS § 35.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Post-hearing briefs. 35.36 Section 35.36...

15 CFR 25.36 - Post-hearing briefs.

Code of Federal Regulations, 2013 CFR

2013-01-01

....36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such briefs, not to... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Post-hearing briefs. 25.36 Section 25...

15 CFR 25.36 - Post-hearing briefs.

Code of Federal Regulations, 2010 CFR

2010-01-01

....36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such briefs, not to... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Post-hearing briefs. 25.36 Section 25...

7 CFR 1.334 - Post-hearing briefs.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Hearings Under the Program Fraud Civil Remedies Act of 1986 § 1.334 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief... 7 Agriculture 1 2013-01-01 2013-01-01 false Post-hearing briefs. 1.334 Section 1.334 Agriculture...

22 CFR 521.36 - Post-hearing briefs.

Code of Federal Regulations, 2010 CFR

2010-04-01

... § 521.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing briefs, at a time not... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Post-hearing briefs. 521.36 Section 521.36...

6 CFR 13.36 - Post-hearing briefs.

Code of Federal Regulations, 2011 CFR

2011-01-01

... § 13.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ will fix the time for filing such briefs. Such briefs... 6 Domestic Security 1 2011-01-01 2011-01-01 false Post-hearing briefs. 13.36 Section 13.36...

22 CFR 521.36 - Post-hearing briefs.

Code of Federal Regulations, 2011 CFR

2011-04-01

... § 521.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing briefs, at a time not... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Post-hearing briefs. 521.36 Section 521.36...

20 CFR 355.36 - Post-hearing briefs.

Code of Federal Regulations, 2010 CFR

2010-04-01

... REGULATIONS UNDER THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 355.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Post-hearing briefs. 355.36 Section 355.36...

7 CFR 1.334 - Post-hearing briefs.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Hearings Under the Program Fraud Civil Remedies Act of 1986 § 1.334 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief... 7 Agriculture 1 2010-01-01 2010-01-01 false Post-hearing briefs. 1.334 Section 1.334 Agriculture...

29 CFR 22.36 - Post-hearing briefs.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 1 2011-07-01 2011-07-01 false Post-hearing briefs. 22.36 Section 22.36 Labor Office of the Secretary of Labor PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 22.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing...

6 CFR 13.36 - Post-hearing briefs.

Code of Federal Regulations, 2013 CFR

2013-01-01

... § 13.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ will fix the time for filing such briefs. Such briefs... 6 Domestic Security 1 2013-01-01 2013-01-01 false Post-hearing briefs. 13.36 Section 13.36...

10 CFR 13.36 - Post-hearing briefs.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Post-hearing briefs. 13.36 Section 13.36 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall...

22 CFR 224.36 - Post-hearing briefs.

Code of Federal Regulations, 2012 CFR

2012-04-01

... ACT § 224.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing briefs, at a time... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Post-hearing briefs. 224.36 Section 224.36...

10 CFR 13.36 - Post-hearing briefs.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Post-hearing briefs. 13.36 Section 13.36 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall...

28 CFR 71.36 - Post-hearing briefs.

Code of Federal Regulations, 2013 CFR

2013-07-01

....36 Post-hearing briefs. ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such briefs, not to exceed 60... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Post-hearing briefs. 71.36 Section 71.36...

5 CFR 185.136 - Post-hearing briefs.

Code of Federal Regulations, 2013 CFR

2013-01-01

... CIVIL REMEDIES § 185.136 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Post-hearing briefs. 185.136 Section 185...

7 CFR 1.334 - Post-hearing briefs.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Hearings Under the Program Fraud Civil Remedies Act of 1986 § 1.334 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief... 7 Agriculture 1 2014-01-01 2014-01-01 false Post-hearing briefs. 1.334 Section 1.334 Agriculture...

28 CFR 71.36 - Post-hearing briefs.

Code of Federal Regulations, 2010 CFR

2010-07-01

....36 Post-hearing briefs. ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such briefs, not to exceed 60... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Post-hearing briefs. 71.36 Section 71.36...

28 CFR 71.36 - Post-hearing briefs.

Code of Federal Regulations, 2012 CFR

2012-07-01

....36 Post-hearing briefs. ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such briefs, not to exceed 60... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Post-hearing briefs. 71.36 Section 71.36...

5 CFR 185.136 - Post-hearing briefs.

Code of Federal Regulations, 2012 CFR

2012-01-01

... CIVIL REMEDIES § 185.136 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Post-hearing briefs. 185.136 Section 185...

28 CFR 71.36 - Post-hearing briefs.

Code of Federal Regulations, 2011 CFR

2011-07-01

....36 Post-hearing briefs. ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such briefs, not to exceed 60... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Post-hearing briefs. 71.36 Section 71.36...

45 CFR 79.36 - Post-hearing briefs.

Code of Federal Regulations, 2012 CFR

2012-10-01

....36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such briefs, not to... 45 Public Welfare 1 2012-10-01 2012-10-01 false Post-hearing briefs. 79.36 Section 79.36 Public...

15 CFR 25.36 - Post-hearing briefs.

Code of Federal Regulations, 2012 CFR

2012-01-01

....36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such briefs, not to... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Post-hearing briefs. 25.36 Section 25...

5 CFR 185.136 - Post-hearing briefs.

Code of Federal Regulations, 2011 CFR

2011-01-01

... CIVIL REMEDIES § 185.136 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Post-hearing briefs. 185.136 Section 185...

22 CFR 521.36 - Post-hearing briefs.

Code of Federal Regulations, 2013 CFR

2013-04-01

... § 521.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing briefs, at a time not... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Post-hearing briefs. 521.36 Section 521.36...

22 CFR 224.36 - Post-hearing briefs.

Code of Federal Regulations, 2013 CFR

2013-04-01

... ACT § 224.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing briefs, at a time... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Post-hearing briefs. 224.36 Section 224.36...

6 CFR 13.36 - Post-hearing briefs.

Code of Federal Regulations, 2012 CFR

2012-01-01

... § 13.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ will fix the time for filing such briefs. Such briefs... 6 Domestic Security 1 2012-01-01 2012-01-01 false Post-hearing briefs. 13.36 Section 13.36...

7 CFR 1.334 - Post-hearing briefs.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Hearings Under the Program Fraud Civil Remedies Act of 1986 § 1.334 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief... 7 Agriculture 1 2012-01-01 2012-01-01 false Post-hearing briefs. 1.334 Section 1.334 Agriculture...

10 CFR 13.36 - Post-hearing briefs.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Post-hearing briefs. 13.36 Section 13.36 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall...

41 CFR 105-70.036 - Post-hearing briefs.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Administration 70-IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 105-70.036 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Post-hearing briefs. 105...

22 CFR 224.36 - Post-hearing briefs.

Code of Federal Regulations, 2014 CFR

2014-04-01

... ACT § 224.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing briefs, at a time... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Post-hearing briefs. 224.36 Section 224.36...

22 CFR 521.36 - Post-hearing briefs.

Code of Federal Regulations, 2014 CFR

2014-04-01

... § 521.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing briefs, at a time not... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Post-hearing briefs. 521.36 Section 521.36...

43 CFR 35.36 - Post-hearing briefs.

Code of Federal Regulations, 2013 CFR

2013-10-01

... CLAIMS AND STATEMENTS § 35.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Post-hearing briefs. 35.36 Section 35.36...

20 CFR 355.36 - Post-hearing briefs.

Code of Federal Regulations, 2011 CFR

2011-04-01

... REGULATIONS UNDER THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 355.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Post-hearing briefs. 355.36 Section 355.36...

5 CFR 185.136 - Post-hearing briefs.

Code of Federal Regulations, 2010 CFR

2010-01-01

... CIVIL REMEDIES § 185.136 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Post-hearing briefs. 185.136 Section 185...

10 CFR 13.36 - Post-hearing briefs.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Post-hearing briefs. 13.36 Section 13.36 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall...

22 CFR 224.36 - Post-hearing briefs.

Code of Federal Regulations, 2010 CFR

2010-04-01

... ACT § 224.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing briefs, at a time... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Post-hearing briefs. 224.36 Section 224.36...

45 CFR 79.36 - Post-hearing briefs.

Code of Federal Regulations, 2014 CFR

2014-10-01

....36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such briefs, not to... 45 Public Welfare 1 2014-10-01 2014-10-01 false Post-hearing briefs. 79.36 Section 79.36 Public...

20 CFR 355.36 - Post-hearing briefs.

Code of Federal Regulations, 2013 CFR

2013-04-01

... REGULATIONS UNDER THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 355.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Post-hearing briefs. 355.36 Section 355.36...

45 CFR 79.36 - Post-hearing briefs.

Code of Federal Regulations, 2011 CFR

2011-10-01

....36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such briefs, not to... 45 Public Welfare 1 2011-10-01 2011-10-01 false Post-hearing briefs. 79.36 Section 79.36 Public...

29 CFR 22.36 - Post-hearing briefs.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 1 2013-07-01 2013-07-01 false Post-hearing briefs. 22.36 Section 22.36 Labor Office of the Secretary of Labor PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 22.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing...

5 CFR 185.136 - Post-hearing briefs.

Code of Federal Regulations, 2014 CFR

2014-01-01

... CIVIL REMEDIES § 185.136 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Post-hearing briefs. 185.136 Section 185...

22 CFR 224.36 - Post-hearing briefs.

Code of Federal Regulations, 2011 CFR

2011-04-01

... ACT § 224.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing briefs, at a time... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Post-hearing briefs. 224.36 Section 224.36...

41 CFR 105-70.036 - Post-hearing briefs.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Administration 70-IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 105-70.036 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Post-hearing briefs. 105...

6 CFR 13.36 - Post-hearing briefs.

Code of Federal Regulations, 2014 CFR

2014-01-01

... § 13.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ will fix the time for filing such briefs. Such briefs... 6 Domestic Security 1 2014-01-01 2014-01-01 false Post-hearing briefs. 13.36 Section 13.36...

7 CFR 1.334 - Post-hearing briefs.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Hearings Under the Program Fraud Civil Remedies Act of 1986 § 1.334 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief... 7 Agriculture 1 2011-01-01 2011-01-01 false Post-hearing briefs. 1.334 Section 1.334 Agriculture...

41 CFR 105-70.036 - Post-hearing briefs.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Administration 70-IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 105-70.036 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Post-hearing briefs. 105...

22 CFR 521.36 - Post-hearing briefs.

Code of Federal Regulations, 2012 CFR

2012-04-01

... § 521.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing briefs, at a time not... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Post-hearing briefs. 521.36 Section 521.36...

15 CFR 25.36 - Post-hearing briefs.

Code of Federal Regulations, 2014 CFR

2014-01-01

....36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such briefs, not to... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Post-hearing briefs. 25.36 Section 25...

43 CFR 35.36 - Post-hearing briefs.

Code of Federal Regulations, 2014 CFR

2014-10-01

... CLAIMS AND STATEMENTS § 35.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Post-hearing briefs. 35.36 Section 35.36...

29 CFR 22.36 - Post-hearing briefs.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 1 2012-07-01 2012-07-01 false Post-hearing briefs. 22.36 Section 22.36 Labor Office of the Secretary of Labor PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 22.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing...

41 CFR 105-70.036 - Post-hearing briefs.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Administration 70-IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 105-70.036 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Post-hearing briefs. 105...

43 CFR 35.36 - Post-hearing briefs.

Code of Federal Regulations, 2012 CFR

2012-10-01

... CLAIMS AND STATEMENTS § 35.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Post-hearing briefs. 35.36 Section 35.36...

10 CFR 13.36 - Post-hearing briefs.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 1 2012-01-01 2012-01-01 false Post-hearing briefs. 13.36 Section 13.36 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall...

15 CFR 25.36 - Post-hearing briefs.

Code of Federal Regulations, 2011 CFR

2011-01-01

....36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such briefs, not to... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Post-hearing briefs. 25.36 Section 25...

20 CFR 355.36 - Post-hearing briefs.

Code of Federal Regulations, 2012 CFR

2012-04-01

... REGULATIONS UNDER THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 355.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false Post-hearing briefs. 355.36 Section 355.36...

45 CFR 79.36 - Post-hearing briefs.

Code of Federal Regulations, 2013 CFR

2013-10-01

....36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing such briefs, not to... 45 Public Welfare 1 2013-10-01 2013-10-01 false Post-hearing briefs. 79.36 Section 79.36 Public...

Ubiquitinated Proteome: Ready for Global?*

PubMed Central

Shi, Yi; Xu, Ping; Qin, Jun

2011-01-01

Ubiquitin (Ub) is a small and highly conserved protein that can covalently modify protein substrates. Ubiquitination is one of the major post-translational modifications that regulate a broad spectrum of cellular functions. The advancement of mass spectrometers as well as the development of new affinity purification tools has greatly expedited proteome-wide analysis of several post-translational modifications (e.g. phosphorylation, glycosylation, and acetylation). In contrast, large-scale profiling of lysine ubiquitination remains a challenge. Most recently, new Ub affinity reagents such as Ub remnant antibody and tandem Ub binding domains have been developed, allowing for relatively large-scale detection of several hundreds of lysine ubiquitination events in human cells. Here we review different strategies for the identification of ubiquitination site and discuss several issues associated with data analysis. We suggest that careful interpretation and orthogonal confirmation of MS spectra is necessary to minimize false positive assignments by automatic searching algorithms. PMID:21339389

On the post mitigation impact risk assessment of possible targets for an asteroid deflection demonstration mission in the NEOShield project.

NASA Astrophysics Data System (ADS)

Eggl, Siegfried

2014-05-01

Mankind believes to have the capabilities to avert potentially disastrous asteroid impacts. Yet, only the realization of a mitigation demonstration mission can confirm such a claim. The NEOShield project, an international collaboration under European leadership, aims to draw a comprehensive picture of the scientific as well as technical requirements to such an endeavor. One of the top priorities of such a demonstration mission is, of course, that a previously harmless target asteroid shall not be turned into a potentially hazardous object. Given the inherently large uncertainties in an asteroid's physical parameters, as well as the additional uncertainties introduced during the deflection attempt, an in depth analysis of the change in asteroid impact probabilities after a deflection event becomes necessary. We present a post mitigation impact risk analysis of a list of potential deflection test missions and discuss the influence of orbital, physical and mitigation induced uncertainties.

IRVE-II Post-Flight Trajectory Reconstruction

NASA Technical Reports Server (NTRS)

O'Keefe, Stephen A.; Bose, David M.

2010-01-01

NASA s Inflatable Re-entry Vehicle Experiment (IRVE) II successfully demonstrated an inflatable aerodynamic decelerator after being launched aboard a sounding rocket from Wallops Flight Facility (WFF). Preliminary day of flight data compared well with pre-flight Monte Carlo analysis, and a more complete trajectory reconstruction performed with an Extended Kalman Filter (EKF) approach followed. The reconstructed trajectory and comparisons to an attitude solution provided by NASA Sounding Rocket Operations Contract (NSROC) personnel at WFF are presented. Additional comparisons are made between the reconstructed trajectory and pre and post-flight Monte Carlo trajectory predictions. Alternative observations of the trajectory are summarized which leverage flight accelerometer measurements, the pre-flight aerodynamic database, and on-board flight video. Finally, analysis of the payload separation and aeroshell deployment events are presented. The flight trajectory is reconstructed to fidelity sufficient to assess overall project objectives related to flight dynamics and overall, IRVE-II flight dynamics are in line with expectations

34 CFR 303.310 - Post-referral timeline (45 days).

Code of Federal Regulations, 2012 CFR

2012-07-01

... 34 Education 2 2012-07-01 2012-07-01 false Post-referral timeline (45 days). 303.310 Section 303... Post-Referral Procedures-Screenings, Evaluations, and Assessments § 303.310 Post-referral timeline (45...) The lead agency must develop procedures to ensure that in the event the circumstances described in (b...

What can we learn from the deadly flash floods? Post Event Review Capability (PERC) analysis of the Bavaria and Baden-Wurttemberg flood events in Summer 2016

NASA Astrophysics Data System (ADS)

Szoenyi, Michael

2017-04-01

In May/June 2016, stationary low pressure systems brought intense rainfall with record-braking intensities of well above 100 mm rain in few hours locally in the southern states of Baden-Wurttemberg and Bavaria, Germany. In steep terrains, small channels and creeks became devastating torrents impacting, among others, the villages of Simbach/Inn, Schwäbisch-Gmünd and Braunsbach. Just few days prior, France had also seen devastating rainfall and flooding. Damage in Germany alone is estimated at 2.8 M USD, of which less than 50% are insured. The loss of life was significant, with 18 fatalities reported across the events. This new forensic event analysis as part of Zurich's Post Event Review Capability (PERC) investigates the flash flood events following these record rainfalls in Southern Germany and tries to answer the following questions holistically, across the five capitals (5C) and the full disaster risk management (DRM) cycle, which are key to understanding how to become more resilient to such flood events: - Why have these intense rainfall events led to such devastating consequences? The EU Floods directive and its implementation in the various member states, as well as the 2002 and 2013 Germany floods, have focused on larger rivers and the main asset concentration. The pathway and mechanism of the 2016 floods are very different and need to be better understood. Flash floods and surface flooding may need to become the new focus and be much better communicated to people at risk, as the awareness for such perils has been identified as low. - How can the prevalence for such flash floods be better identified and mapped? Research indicated that affected people and decision makers alike attribute the occurrence of such flash floods as arbitrary, but we argue that hotspots can and must be identified based on an overlay of rainfall intensity maps, topography leading to flash flood processes, and vulnerable assets. In Germany, there are currently no comprehensive hazard maps for flash and/or surface flooding. - What recommendations can be made from the investigation of the consequences? We highlight how additional processes that cause significant damage, such as log jams, backwater increase, temporary dam formation, etc., are currently insufficiently understood and incorporated into decision-making. - What are the social and human long-term effects of such flash flood events, and how can the insights from this review be incorporated into future decision-making to better protect people and assets as part of integrated flood risk management?