Science.gov

Sample records for post fantastic results

  1. The fantastic four.. elements

    NASA Astrophysics Data System (ADS)

    Marsili, Antonella; D'Addezio, Giuliana; Rubbia, Giuliana; Ramieri, Caterina; Todaro, Riccardo; Scipilliti, Francesca; Tosto, Eleonora

    2015-04-01

    With a "Sunday between territory and music to 'National Institute of Geophysics and Volcanology," October 12, 2014 the headquarters of INGV Roma kicked off the activities of the second edition of the Week of Planet Earth. The laboratory of scientific outreach and museum activities together with volunteers of the National Civil Service have organized the whole day dedicated to the dissemination of earth sciences, involving adults and children. Especially for primary school children a laboratory was made involving three amusing activities all aimed at inspiring respect for the Earth: a theatrical representation called "The Fantastic 4... elements", a behavioral game and a nursery rhyme reading. The theater as a means of communication of science is an innovative and creative way to introduce children to important scientific concepts. The use of this methodology and simple language favoring the emotional involvement of the child facilitating learning. The main character is a child, chosen to facilitate the identification of the spectators with the protagonist, that through a fantastic journey discovers the importance of the four elements of our planet: earth, fire, air and water. As a second step, volunteers involved children in reading a nursery rhyme "the ABC to become a Friend of the Earth" inviting them to protect and respect the environment and its resources. Finally, the behavioral game gave indications about behaviors to adopt to safeguard the planet. Volunteers introduced a billboard divided into two colors, green to indicate the right behaviors and red for the wrong ones. Each child, after reading a card with indication on the behavior to adopt, had to decide if they were correct or not with respect to the environment safeguard. After listening to the children's answer, the volunteer gave the correct explanation about the appropriate behavior to adopt. At the end of the activities, each child received a certificate as "a friend of Planet Earth".

  2. A Visit from the Candy Witch: Factors Influencing Young Children's Belief in a Novel Fantastical Being

    ERIC Educational Resources Information Center

    Woolley, Jacqueline D.; Boerger, Elizabeth A.; Markman, Arthur B.

    2004-01-01

    Factors hypothesized to affect beliefs in fantastical beings were examined by introducing children to a novel fantastical entity, the Candy Witch. Results revealed that among older preschoolers, children who were visited by the Candy Witch exhibited stronger beliefs in the Candy Witch than did those who were not. Among children who were visited,…

  3. Fantastic Fauve Faces

    ERIC Educational Resources Information Center

    Nessom, Jennifer

    2010-01-01

    The wonderful book, "How Are You Peeling? Foods with Moods" by Saxton Freymann and Joost Elffers inspired a lesson on feelings and expressions for this author's second-grade students. Many students at her school have difficult lives and lots of emotional baggage, resulting in behavioral problems at school. Using the example of Fauvist portraits by…

  4. Can that really happen? Children's knowledge about the reality status of fantastical events in television.

    PubMed

    Li, Hui; Boguszewski, Katherine; Lillard, Angeline S

    2015-11-01

    Although popular children's cartoons are replete with fantastical events, we know little about whether children understand that these events are fantastical rather than real. In Study 1, 54 children ages 4 to 6 years and 18 adults were shown 10 real and 10 fantastical events portrayed in 4s video clips from a popular cartoon. After viewing each clip, participants were asked to judge the reality status of the event and to explain their judgments. Results indicated that even 4-year-olds have a fairly good understanding of fantastical events in animated cartoons but that they underestimate the reality status of real events in such cartoons. In Study 2, 35 4- to 6-year-olds and 18 adults watched video clips of 10 real and 10 fantastical events performed by real people from a Chinese television show. Once again, 4-year-olds underestimated the reality status of real events shown on television. However, against the "real" backdrop in this study, 4-year-olds also judged nearly half of the fantastical events to be real. The implications for children's reality-fantasy discrimination and their media viewing are discussed.

  5. Can that really happen? Children's knowledge about the reality status of fantastical events in television.

    PubMed

    Li, Hui; Boguszewski, Katherine; Lillard, Angeline S

    2015-11-01

    Although popular children's cartoons are replete with fantastical events, we know little about whether children understand that these events are fantastical rather than real. In Study 1, 54 children ages 4 to 6 years and 18 adults were shown 10 real and 10 fantastical events portrayed in 4s video clips from a popular cartoon. After viewing each clip, participants were asked to judge the reality status of the event and to explain their judgments. Results indicated that even 4-year-olds have a fairly good understanding of fantastical events in animated cartoons but that they underestimate the reality status of real events in such cartoons. In Study 2, 35 4- to 6-year-olds and 18 adults watched video clips of 10 real and 10 fantastical events performed by real people from a Chinese television show. Once again, 4-year-olds underestimated the reality status of real events shown on television. However, against the "real" backdrop in this study, 4-year-olds also judged nearly half of the fantastical events to be real. The implications for children's reality-fantasy discrimination and their media viewing are discussed. PMID:26094241

  6. Stellar students win fantastic prizes

    NASA Astrophysics Data System (ADS)

    2008-05-01

    School students and teachers across Europe and around the world are discovering today who has won fantastic prizes in "Catch a Star", the international astronomical competition run by ESO and the European Association for Astronomy Education (EAAE). CAS2008 artwork ESO PR Photo 14/08 One of the winning artworks "We were extremely impressed by the high quality of the entries, and the number of participants was even higher than last year. We wish to congratulate everybody who took part," said Douglas Pierce-Price, Education Officer at ESO. "'Catch a Star' clearly shows astronomy's power to inspire and excite students of all ages," added Fernand Wagner, President of the EAAE. The top prize, of a week-long trip to Chile to visit the ESO Very Large Telescope (VLT) on Paranal, was won by students Roeland Heerema, Liesbeth Schenkels, and Gerben Van Ranst from the Instituut Spijker in Hoogstraten, Belgium, together with their teacher Ann Verstralen. With their "story of aged binary stars... Live and Let Die", they take us on a vivid tour of the amazing zoo of binary stars, and the life and death of stars like our Sun. The students show how state-of-the-art telescopes, particularly those at ESO's sites of La Silla and Paranal, help us understand these stars. They take as an illustrative example the binary star system V390 Velorum. In the last phases of its life, V390 Velorum will shed its outer shell of gas and dust, turning from a celestial chrysalis into a beautiful cosmic butterfly. The students also involved other pupils from their school, showing them how to test their eyesight by observing the binary star system of Alcor and Mizar. But perhaps the most important discovery they made is that, as they write in their report, "Astronomy lives! Discoveries are being made each day and there is still very much to be found and learned by astronomers!" The team will travel to Chile and visit the ESO VLT - the world's most advanced optical/infrared telescope. At Paranal, they

  7. Stellar students win fantastic prizes

    NASA Astrophysics Data System (ADS)

    2008-05-01

    School students and teachers across Europe and around the world are discovering today who has won fantastic prizes in "Catch a Star", the international astronomical competition run by ESO and the European Association for Astronomy Education (EAAE). CAS2008 artwork ESO PR Photo 14/08 One of the winning artworks "We were extremely impressed by the high quality of the entries, and the number of participants was even higher than last year. We wish to congratulate everybody who took part," said Douglas Pierce-Price, Education Officer at ESO. "'Catch a Star' clearly shows astronomy's power to inspire and excite students of all ages," added Fernand Wagner, President of the EAAE. The top prize, of a week-long trip to Chile to visit the ESO Very Large Telescope (VLT) on Paranal, was won by students Roeland Heerema, Liesbeth Schenkels, and Gerben Van Ranst from the Instituut Spijker in Hoogstraten, Belgium, together with their teacher Ann Verstralen. With their "story of aged binary stars... Live and Let Die", they take us on a vivid tour of the amazing zoo of binary stars, and the life and death of stars like our Sun. The students show how state-of-the-art telescopes, particularly those at ESO's sites of La Silla and Paranal, help us understand these stars. They take as an illustrative example the binary star system V390 Velorum. In the last phases of its life, V390 Velorum will shed its outer shell of gas and dust, turning from a celestial chrysalis into a beautiful cosmic butterfly. The students also involved other pupils from their school, showing them how to test their eyesight by observing the binary star system of Alcor and Mizar. But perhaps the most important discovery they made is that, as they write in their report, "Astronomy lives! Discoveries are being made each day and there is still very much to be found and learned by astronomers!" The team will travel to Chile and visit the ESO VLT - the world's most advanced optical/infrared telescope. At Paranal, they

  8. The Fantastic Four of Mathematics Assessment Items

    ERIC Educational Resources Information Center

    Greenlees, Jane

    2011-01-01

    In this article, the author makes reference to four comic book characters to make the point that together they are a formidable team, but on their own they are vulnerable. She examines the four components of mathematics assessment items and the need for implicit instruction within the classroom for student success. Just like the "Fantastic Four"…

  9. The effects of fantastical pretend-play on the development of executive functions: An intervention study.

    PubMed

    Thibodeau, Rachel B; Gilpin, Ansley T; Brown, Melissa M; Meyer, Brooke A

    2016-05-01

    Although recent correlational studies have found a relationship between fantasy orientation (FO; i.e., a child's propensity to play in a fantastical realm) and higher order cognitive skills called executive functions (EFs), no work has addressed the causality and directionality of this relationship. The current study experimentally examined the directionality of the observed relationship between FO and EF development in preschool-aged children through an innovative play intervention employing a randomized controlled design. A sample of 110 children between the ages of 3 and 5years were randomly assigned to one of three conditions: fantastical pretend-play intervention, non-imaginative play intervention, or business-as-usual control. Results revealed that children who participated in a 5-week fantastical pretend-play intervention showed improvements in EFs, whereas children in the other two conditions did not. Within the fantastical pretend-play condition, children who were highly engaged in the play and those who were highly fantastical demonstrated the greatest gains in EFs. These data provide evidence for the equifinal relationship between fantasy-oriented play and EF development, such that engaging in fantasy-oriented play may be one of many ways to directly enhance EF development. PMID:26835841

  10. VLAP: results immediately post-op

    NASA Astrophysics Data System (ADS)

    Cowles, Robert S.

    1996-05-01

    Visual laser ablation of the prostate (VLAP) has been shown to be as effective with fewer complications than TURP in the treatment of bladder outlet obstruction secondary to benign prostatic hyperplasia. Questions have been raised about VLAP regarding prolonged irritative and obstructive voiding symptoms postoperatively. It is postulated that these symptoms are due to the slow slough of necrotic debris following VLAP. In an effort to improve upon the technique of VLAP, patients underwent lasing of the prostate in the routine manner (2, 4, 8, and 10 o'clock positions with sixty watts for sixty seconds) using Nd:YAG free beam energy. A bladder neck incision was then performed using a contact laser fiber. International prostate symptom score assessments were done preoperatively; one week and six weeks postoperatively. Post void residual urine volumes and prostate size were also evaluated. The findings indicate that symptom scores and post void residual urine volumes have significantly improved within ten days postoperatively using this technique.

  11. Fantastic animals as an experimental model to teach animal adaptation

    PubMed Central

    Guidetti, Roberto; Baraldi, Laura; Calzolai, Caterina; Pini, Lorenza; Veronesi, Paola; Pederzoli, Aurora

    2007-01-01

    Background Science curricula and teachers should emphasize evolution in a manner commensurate with its importance as a unifying concept in science. The concept of adaptation represents a first step to understand the results of natural selection. We settled an experimental project of alternative didactic to improve knowledge of organism adaptation. Students were involved and stimulated in learning processes by creative activities. To set adaptation in a historic frame, fossil records as evidence of past life and evolution were considered. Results The experimental project is schematized in nine phases: review of previous knowledge; lesson on fossils; lesson on fantastic animals; planning an imaginary world; creation of an imaginary animal; revision of the imaginary animals; adaptations of real animals; adaptations of fossil animals; and public exposition. A rubric to evaluate the student's performances is reported. The project involved professors and students of the University of Modena and Reggio Emilia and of the "G. Marconi" Secondary School of First Degree (Modena, Italy). Conclusion The educational objectives of the project are in line with the National Indications of the Italian Ministry of Public Instruction: knowledge of the characteristics of living beings, the meanings of the term "adaptation", the meaning of fossils, the definition of ecosystem, and the particularity of the different biomes. At the end of the project, students will be able to grasp particular adaptations of real organisms and to deduce information about the environment in which the organism evolved. This project allows students to review previous knowledge and to form their personalities. PMID:17767729

  12. The Fantastic Tale for Children: A Genre Study from the Viewpoints of Literary and Educational Research.

    ERIC Educational Resources Information Center

    Klingberg, Gote

    The literary genre explored in this study is The Fantastic Tale for Children, which combines magic and reality. Two examples of the "pure" fantastic tale are "The Return of the Twelves" by Pauline Clarke and "Tom's Midnight Garden" by Philippa Pearce. The motifs of the fantastic tale are methods which connect the world of the principal characters…

  13. The Fantastic Tale for Children: Its Literary and Educational Problems.

    ERIC Educational Resources Information Center

    Klingberg, Goete

    1967-01-01

    The fantastic tale is a genre of children's literature in which magic and reality are found side by side in a superficially plausible story with a definite historical setting. Motifs characteristic of the tale are living toys, strange children, modern witches, space and time displacements, "doors" to the wonderland, the mythical world itself, and…

  14. Preschoolers Can Infer General Rules Governing Fantastical Events in Fiction

    ERIC Educational Resources Information Center

    Van de Vondervoort, Julia W.; Friedman, Ori

    2014-01-01

    Young children are frequently exposed to fantastic fiction. How do they make sense of the unrealistic and impossible events that occur in such fiction? Although children could view such events as isolated episodes, the present experiments suggest that children use such events to infer general fantasy rules. In 2 experiments, 2-to 4-year-olds were…

  15. 25 CFR 81.23 - Posting and certifying election results.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Posting and certifying election results. 81.23 Section 81... REORGANIZATION UNDER A FEDERAL STATUTE § 81.23 Posting and certifying election results. (a) The results of the... appropriate public places determined by the election board. (b) The election board shall certify the...

  16. 25 CFR 81.23 - Posting and certifying election results.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Posting and certifying election results. 81.23 Section 81... REORGANIZATION UNDER A FEDERAL STATUTE § 81.23 Posting and certifying election results. (a) The results of the... appropriate public places determined by the election board. (b) The election board shall certify the...

  17. 25 CFR 81.23 - Posting and certifying election results.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Posting and certifying election results. 81.23 Section 81... REORGANIZATION UNDER A FEDERAL STATUTE § 81.23 Posting and certifying election results. (a) The results of the... appropriate public places determined by the election board. (b) The election board shall certify the...

  18. 25 CFR 81.23 - Posting and certifying election results.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Posting and certifying election results. 81.23 Section 81... REORGANIZATION UNDER A FEDERAL STATUTE § 81.23 Posting and certifying election results. (a) The results of the... appropriate public places determined by the election board. (b) The election board shall certify the...

  19. 25 CFR 81.23 - Posting and certifying election results.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Posting and certifying election results. 81.23 Section 81... REORGANIZATION UNDER A FEDERAL STATUTE § 81.23 Posting and certifying election results. (a) The results of the... appropriate public places determined by the election board. (b) The election board shall certify the...

  20. Urania In The Marketplace: Telescopes, Real And Fantastic

    NASA Astrophysics Data System (ADS)

    Rumstay, Kenneth S.

    2012-01-01

    During the twentieth century astronomical imagery was frequently incorporated, by a variety of industrial manufacturers, into advertisements which appeared in popular magazines. Images of great telescopes, especially, were often invoked to capture the public imagination and to associate a product or service with the noble pursuit of astronomical knowledge. These advertisements fall into three general categories: 1)In many cases the advertiser may have participated directly in the construction or operation of a new telescope or observatory. That astronomical facility would then be accurately rendered, usually by a photograph, and often identified. 2) In the case of a product or service which had at best a tangential relation to astronomy, a generic telescope or observatory dome might be pictured, with no identification. The intent would be to co-opt the qualities of precision and timeliness, commonly associated with astronomy, for the advertiser's product. In some cases a well-known observatory (most notably the ones atop Mount Wilson and Mount Palomar) would provide a backdrop, thereby linking the manufacturer with a facility in the public eye. 3) In some cases, a service or product might have no astronomical association whatever. Nonetheless, the advertiser might employ an image of a large telescope to invoke a sense of grandeur which would somehow be transferred, in the reader's mind, to that product. In these cases an artist's conception of some fantastic device would often be prepared. In some cases the artist may have had only the vaguest idea of how telescopes were designed, and as a result some remarkably imaginative examples of astronomical engineering graced the pages of our periodicals. Examples of magazine advertisements from each category, spanning nearly a century, are presented for comparison.

  1. Preschoolers can infer general rules governing fantastical events in fiction.

    PubMed

    Van de Vondervoort, Julia W; Friedman, Ori

    2014-05-01

    Young children are frequently exposed to fantastic fiction. How do they make sense of the unrealistic and impossible events that occur in such fiction? Although children could view such events as isolated episodes, the present experiments suggest that children use such events to infer general fantasy rules. In 2 experiments, 2- to 4-year-olds were shown scenarios in which 2 animals behaved unrealistically (N = 78 in Experiment 1, N = 94 in Experiment 2). When asked to predict how other animals in the fiction would behave, children predicted novel behaviors consistent with the nature of the fiction. These findings suggest that preschoolers can infer the general rules that govern the events and entities in fantastic fiction and can use these rules to predict what events will happen in the fiction. The findings also provide evidence that children may infer fantasy rules at a more superordinate level than the basic level.

  2. Return of the Candy Witch: Individual differences in acceptance and stability of belief in a novel fantastical being

    PubMed Central

    Boerger, Elizabeth A.; Tullos, Ansley; Woolley, Jacqueline D.

    2009-01-01

    Recent research indicates that preschoolers make sophisticated choices in accepting testimony as a source of knowledge. Nonetheless, many children accept fantastical beings as real based on misleading testimony. The present study probes factors associated with belief in a novel fantastical figure, the Candy Witch, that 3- to 7-year-olds heard about at school. Short-term belief was predicted by an interaction of age, existing beliefs in fantastical figures, and whether the child was ‘visited’ by the Candy Witch. Stability of belief was assessed over the course of 3 weeks and again 1-year later. First year results revealed three patterns of belief: stable belief, wavering belief and stable non-belief. First year belief status was not related to age, but older children from the stable belief group were more likely than younger children to disbelieve 1-year later. The discussion presents a new proposal for the trajectory from belief to disbelief and an updated perspective on the role of individual differences in belief. PMID:19994488

  3. 'Distorteidolias' - fantastic perceptive distortion. A new, pure dorsomedial thalamic syndrome.

    PubMed

    Delgado, Montserrat G; Bogousslavsky, Julien

    2013-01-01

    The role of the thalamus in the pathogenesis of the visual and auditory hallucinations has been reported under the name of peduncular hallucinosis, usually with coexisting midbrain involvement. These hallucinations typically take the form of dreamy de novo productions (phanteidolias), less often that of transformations of perceptions into new items (such as seeing faces in clouds) called pareidolias. However, hallucinations taking the form of a complex distortion of perception is a different phenomenon, which to our knowledge has not been reported. We studied 2 patients with complex, 'fantastic', perceptive distortion involving the visual and auditory systems after thalamic stroke limited to the region of the dorsomedial nucleus, sparing the intralaminar nuclei and the midbrain (explaining the lack of disorders of consciousness and confusional state). Our patients reported the modification of usual stimuli (face, body, voices) into unreal, fantastically distorted perceptions (monstrous change of shapes or sounds without appearance of new items). While the exact mechanism leading to such perceptive distortions remains unknown, a release phenomenon due to damage to the dorsomedial thalamus (probably affecting cholinergic system) responsible for a disinhibition of cortical function involved in familiarity of perception seems likely. We suggest that these hallucinations should be called 'distorteidolias'.

  4. US RERTR FUEL DEVELOPMENT POST IRRADIATION EXAMINATION RESULTS

    SciTech Connect

    A. B. Robinson; D. M. Wachs; D. E. Burkes; D. D. Keiser

    2008-10-01

    Post irradiation examinations of irradiated RERTR plate type fuel at the Idaho National Laboratory have led to in depth characterization of fuel behavior and performance. Both destructive and non-destructive examination capabilities at the Hot Fuels Examination Facility (HFEF) as well as recent results obtained are discussed herein. New equipment as well as more advanced techniques are also being developed to further advance the investigation into the performance of the high density U-Mo fuel.

  5. Post-AGB Stars in the Magellanic Clouds: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Kamath, D.; Wood, P. R.; van Winckel, H.; van Aarle, E.

    2011-12-01

    The evolution and mass-loss of red giants is poorly understood. It is difficult to empirically estimate the mass-loss rate and the chemical abundance changes, as a function of initial mass and metallicity. Post-AGB stars are key objects in the study of the dramatic chemical and morphological changes of stars along the AGB ascent and subsequent evolution towards the Planetary Nebula phase. Thus studying these objects would help in understanding the different physical processes and the chemical evolution that occur during these evolutionary phases. Using the AAOmega multi-fibre spectrograph on the AAT, we carried out an extensive low-resolution spectral survey of several thousand post-AGB candidates, in the Large Magellanic Cloud and the Small Magellanic Cloud. The candidates were selected from the mid-IR Spitzer Space Telescope surveys: SAGE and SAGE-SMC. In this paper we present preliminary results from our survey, delineating the regions of the HR diagram where post-AGB stars are found and where Hα-emission occurs.

  6. Achieving optimum post mine reclamation results through computer aided design

    SciTech Connect

    Johnson, M.; Irvin, R.; Metcalf, D.

    1997-12-31

    Recent technological advances have made it possible to map and model disturbed mine areas to plan the most cost effective manner in which to reclaim post mine land. The process not only can reduce the cost to reclaim each acre, but also enhances regulatory compliance. Results from a 21 acre test at Texas Utilities Mining Company`s Martin Lake-Oak Hill Mine have shown a significant reduction in dozer hours per acre to complete reclamation. A larger, more conclusive project has been completed at TUMCO`s Monticello-Winfield North Mine. The new project includes approximately 350 acres of the C-Area final pit. Results of this project have resulted in substantial cost savings versus conventional reclamation planning methods.

  7. Orbiter post-tire failure and skid testing results

    NASA Technical Reports Server (NTRS)

    Daugherty, Robert H.; Stubbs, Sandy M.

    1989-01-01

    An investigation was conducted at the NASA Langley Research Center's Aircraft Landing Dynamics Facility (ALDF) to define the post-tire failure drag characteristics of the Space Shuttle Orbiter main tire and wheel assembly. Skid tests on various materials were also conducted to define their friction and wear rate characteristics under higher speed and bearing pressures than any previous tests. The skid tests were conducted to support a feasibility study of adding a skid to the orbiter strut between the main tires to protect an intact tire from failure due to overload should one of the tires fail. Roll-on-rim tests were conducted to define the ability of a standard and a modified orbiter main wheel to roll without a tire. Results of the investigation are combined into a generic model of strut drag versus time under failure conditions for inclusion into rollout simulators used to train the shuttle astronauts.

  8. Preliminary Results From The Neowise Post-cryogenic Mission

    NASA Astrophysics Data System (ADS)

    Mainzer, Amanda K.; Bauer, J.; Grav, T.; Masiero, J.; Cutri, R. M.; McMillan, R. S.; Walker, R.; Dailey, J.; Nugent, C. R.; Conrow, T.; Wright, E.

    2012-10-01

    NASA's Wide-field Infrared Survey Explorer mission surveyed the entire sky in four infrared wavelengths: 3.4, 4.6, 12 and 22 um (denoted W1, W2, W3, and W4 respectively). Images were collected in all four bands simultaneously using beamsplitters; cooling for all four detectors was provided by dual solid hydrogen tanks. Survey operations began on 14 January, 2010, and the first pass on the entire sky was completed six months later. However, coverage of the solar system was incomplete owing to the long synodic periods of near-Earth objects (NEOs) and many Main Belt asteroids. The hydrogen tank that provided cooling to the W3 and W4 Si:As detectors was exhausted on 5 August, 2010, resulting in the near-immediate loss of the 22 um channel that same day. As the remaining hydrogen in the second tank sublimed away, both the detectors and the telescope temperature rose. During this period, the 12 um channel continued to operate (albeit with reduced sensitivity) until 29 September, 2010. On that day, the secondary tank's hydrogen supply was finally exhausted, and the telescope temperature rose. Immediately thereafter, NASA's Planetary Science Directorate funded a four month extension of the mission, the NEOWISE Post-Cryogenic Mission, to search for new asteroids and to fill in the gap in coverage of the solar system. The telescope temperature stabilized at 73.5 K, cold enough to allow observations in the two shortest wavelengths. The W1 and W2 arrays operated with minimal performance degradation. Survey operations concluded on 1 February, 2011. We present the preliminary results from the NEOWISE Post-Cryogenic Mission on NEOs.

  9. Synthetic Micro/Nanomachines and Their Applications: Towards 'Fantastic Voyage'

    NASA Astrophysics Data System (ADS)

    Gao, Wei

    The 1966 movie Fantastic Voyage captured the world's imagination, portraying a tiny submarine navigating through the human bloodstream and treating life-threatening medical conditions. My PhD research focuses on the synthetic nano/microscale machines to realize the Fantastic Voyage vision. Various biomedical and environmental areas would benefit from the developments of efficient fuel-free and fuel-driven nano/microscale machines. The polymer-based catalytic tubular microengine is synthesized using a template based electrodeposition method. The oxygen bubble propelled microengine harvests the energy from chemical fuels (such as H2O2) and displays very efficient propulsion. It can serve as an ideal platform for diverse biomedical and environmental applications. For example, lectin modified polyaniline based microengines can be used for selective bacteria (E. Coli) isolation from food, clinical and environmental samples; poly(3-aminophenylboronic acid)/Ni/Pt microengine itself provides the 'built in' glucose recognition capability for 'on-the-fly' capture, transport and release of yeast cells. A series of micromotors which can be self-propelled in natural environments without additional chemical fuels are developed, holding great promise for in vivo biomedical applications: the polyaniline/zinc microrockets display effective autonomous motion in extreme acidic environments (such as human stomach); the Al-Ga/Ti based Janus micromotor can be propelled by the hydrogen bubbles generated from the rapid aluminum and water reaction; alkanethiols modified seawater-driven Mg Janus micromotors, which utilize macrogalvanic corrosion and chloride pitting corrosion processes, can be used for environmental oil remediation. Magnetically powered nanoswimmers have attracted considerable attention due to their great biocompatibility. A high-speed magnetically-propelled nanowire swimmer which mimics swimming microorganisms by exploiting the flexible nanowire as artificial flagella

  10. EURECA 11 months in orbit: Initial post flight investigation results

    NASA Technical Reports Server (NTRS)

    Dover, Alan; Aceti, Roberto; Drolshagen, Gerhard

    1995-01-01

    This paper gives a brief overview of the European free flying spacecraft 'EURECA' and the initial post flight investigations following its retrieval in June 1993. EURECA was in low earth orbit for 11 months commencing in August 1992, and is the first spacecraft to be retrieved and returned to Earth since the recovery of LDEF. The primary mission objective of EURECA was the investigation of materials and fluids in a very low micro-gravity environment. In addition other experiments were conducted in space science, technology and space environment disciplines. The European Space Agency (ESA) has taken the initiative in conducting a detailed post-flight investigation to ensure the full exploitation of this unique opportunity.

  11. Fantastic voyage: live long enough to live forever. The science behind radical life extension questions and answers.

    PubMed

    Kurzweil, Ray; Grossman, Terry

    2009-01-01

    Putting an end to human aging is now becoming a reality, and immortality is no longer just a dream. Through what we are calling "Fantastic Voyage," we provide a guide to achieving life extension through various means, thereby slowing down aging and disease processes. The three components of Fantastic Voyage are: Bridge One--Aggressively applying today's knowledge. Bridge Two--Putting biotechnology, such as gene technologies, to use with therapeutic cloning and rejuvenation medicine. Bridge Three--Putting nanotechnology to use by developing a means to rebuild our bodies and brains with nanobots. Many of these technology solutions can be simulated today through the use of targeted supplements, designed to address the specific needs of an individual, such as insulin resistance, cholesterol and homocysteine levels, and inflammation. To slow aging now, we propose a program of supplementing aggressively, eating foods that impede aging and disease processes, and reversing inflammation through diet. We also provide guidance to customize each program to the specific needs of the individual. Emerging technologies in rational drug design, tissue engineering, gene therapy, and nanobots (among others) promise a future of automated life extension. The use of such technologies, and the resulting dramatic increases in productivity in all areas of human endeavor, will enable us to live in a world in which all our physical needs can be met. PMID:19745481

  12. Fantastic voyage: live long enough to live forever. The science behind radical life extension questions and answers.

    PubMed

    Kurzweil, Ray; Grossman, Terry

    2009-01-01

    Putting an end to human aging is now becoming a reality, and immortality is no longer just a dream. Through what we are calling "Fantastic Voyage," we provide a guide to achieving life extension through various means, thereby slowing down aging and disease processes. The three components of Fantastic Voyage are: Bridge One--Aggressively applying today's knowledge. Bridge Two--Putting biotechnology, such as gene technologies, to use with therapeutic cloning and rejuvenation medicine. Bridge Three--Putting nanotechnology to use by developing a means to rebuild our bodies and brains with nanobots. Many of these technology solutions can be simulated today through the use of targeted supplements, designed to address the specific needs of an individual, such as insulin resistance, cholesterol and homocysteine levels, and inflammation. To slow aging now, we propose a program of supplementing aggressively, eating foods that impede aging and disease processes, and reversing inflammation through diet. We also provide guidance to customize each program to the specific needs of the individual. Emerging technologies in rational drug design, tissue engineering, gene therapy, and nanobots (among others) promise a future of automated life extension. The use of such technologies, and the resulting dramatic increases in productivity in all areas of human endeavor, will enable us to live in a world in which all our physical needs can be met.

  13. Exploring the brain, looking for thoughts: on Asimov's second Fantastic Voyage.

    PubMed

    Cassou-Noguès, Pierre

    2011-01-01

    The aim of this paper is to investigate various concerns which appear in Isaac Asimov's Fantastic Voyage II: Destination Brain. I will disregard his first voyage inside a human body in Fantastic Voyage I, which the author disavows as not being his own work. In contrast, the second voyage is intricate, suggesting problems drawn from a variety of sources. In a nutshell, Asimov's explorers enter the body of a comatose man in order to read his thoughts. The story can be related both to philosophical thought-experiments, such as those of Gottfried Wilhelm Leibniz and of Herbert Feigl, as well as to personal anxieties peculiar to Asimov.

  14. Return of the Candy Witch: Individual Differences in Acceptance and Stability of Belief in a Novel Fantastical Being

    ERIC Educational Resources Information Center

    Boerger, Elizabeth A.; Tullos, Ansley; Woolley, Jacqueline D.

    2009-01-01

    Recent research indicates that preschoolers make sophisticated choices in accepting testimony as a source of knowledge. Nonetheless, many children accept fantastical beings as real based on misleading testimony. The present study probes factors associated with belief in a novel fantastical figure, the Candy Witch, that 3- to 7-year-olds heard…

  15. Creating and Comprehending the Fantastic: A Case Study of a Child from Twenty to Thirty-Five Months.

    ERIC Educational Resources Information Center

    Crago, Maureen

    1993-01-01

    Explores the recorded remarks of one infant female child related to children's books. Contrasts the "fantastic" statements spontaneously generated by the child with the ways in which she responded to animism and other "fantastic" conventions in picture books heard by her at the same ages. (HB)

  16. [Post-arrest memory disorders. Results of a retrospective study].

    PubMed

    Barbey, I

    1990-07-01

    A retrospective study on 362 criminal responsibility reports showed a high proportion of accused persons claiming amnesia for the offence. Subjects of the amnesic group were compared with a non-amnesic control group. Statistically significant relations were found between amnesia and sex, imprisonment, nature of the offence, exogenous factors and psychogenic disturbances. Results of this study and of other published studies confirm the problems in differentiating etiology of amnesia after criminal offences. Valid and reliable diagnostic techniques especially for detecting simulated amnesia are missed. Misconceptions about amnesia are still widespread among judges, lawyers and offenders. Because amnesia occurs after crime it is not necessary for assessing criminal responsibility.

  17. Incidence and Predictors of Microbiology Results Returning Post-Discharge and Requiring Follow-up

    PubMed Central

    El-Kareh, Robert; Roy, Christopher; Brodsky, Gregor; Perencevich, Molly; Poon, Eric G.

    2013-01-01

    Background Failure to follow up microbiology results pending at discharge can delay appropriate treatment, increasing the risk of patient harm and litigation. Limited data describe the frequency of post-discharge microbiology results requiring a treatment change. Objective To determine the incidence and predictors of post-discharge microbiology results requiring follow-up Design Cross sectional Setting Large academic hospital during 2007 Measurements We evaluated blood, urine, sputum and cerebral spinal fluid (CSF) cultures ordered for hospitalized patients. We identified cultures that returned post-discharge and determined which were clinically important and not treated by an antibiotic to which they were susceptible. We reviewed a random subset to assess the potential need for antibiotic change. Using logistic regression, we identified significant predictors of results requiring follow-up. Results Of 77,349 inpatient culture results, 8,668 (11%) returned post-discharge. Of these, 385 (4%) were clinically important and untreated at discharge. Among 94 manually-reviewed cases, 53% potentially required a change in therapy. Urine cultures were more likely to potentially require therapy change than non-urine cultures (aOR 2.8, 95% CI 1.1–7.2; p=0.03). Also, 76% of 25 results from surgical services potentially required a therapy change, compared with 59% of 29 results from general medicine, 38% of 16 results from oncology and 33% of 24 results from medical subspecialties. Overall, 2.4% of post-discharge cultures potentially necessitated an antibiotic change. Conclusion Many microbiology results return post-discharge and some necessitate a change in treatment. These results arise from many specialties, suggesting the need for a hospital-wide system to ensure effective communication of these results. PMID:21661103

  18. Performance effects resulting from plugged liquid oxygen posts of the Space Shuttle Main Engine Injector

    NASA Technical Reports Server (NTRS)

    Kim, S.; Trinh, H. P.

    1992-01-01

    The paper discusses the performance effects resulting from plugged LOX posts of the Space Shuttle Main Engine Injector. The simulation was performed with the REFLEQS 2-D code. Analysis was performed axisymmetrically and injector surface was divided into several regions to account for the mixture ratio variation on the injector surface. The reduction of vaccum specific impulse was approximately 0.01 second per plugged LOX post. This reduction is an order of magnitude higher than the result of Space Shuttle flight reconstruction data. It is presumed that this overprediction is due to the axisymmetric simulation that smears local effects.

  19. Light fantastic

    NASA Astrophysics Data System (ADS)

    2010-05-01

    The laser has become so ubiquitous that it would be impossible to acknowledge everyone who has played a role in its success. As Roy Glauber said at the 2005 Nobel-prize banquet, when it comes to lasers, "many hands make light work". And he should know: the prize Glauber shared with fellow optics pioneers John Hall and Theodore Hänsch is one of more than 10 Nobels awarded (so far!) for laser-related research. This timeline marking 50 years of the laser contains Physics World's pick of events from laser history, including prizes (gold text), applications (green) and "firsts" (blue).

  20. Fantastic Frogs!

    ERIC Educational Resources Information Center

    Scott, Kym

    2002-01-01

    Number rhymes can be used in many exciting and different ways to support the early learning goals for mathematics. The rhyme "five little speckled frogs" provides the theme for this display, which was set up in Lewisham's professional development center. It provides a range of ideas which would help develop young children's mathematical learning…

  1. Fantastic plastic

    NASA Astrophysics Data System (ADS)

    2013-10-01

    Flexible and stretchable solar cells and light-emitting diodes are respectively perceived as being next-generation photovoltaic and lighting technologies, and are attracting the attention of the general public.

  2. Creatures in the Classroom: Preservice Teacher Beliefs About Fantastic Beasts, Magic, Extraterrestrials, Evolution and Creationism

    NASA Astrophysics Data System (ADS)

    Losh, Susan Carol; Nzekwe, Brandon

    2011-05-01

    Faculty have long expressed concern about pseudoscience belief among students. Most US research on such beliefs examines evolution-creation issues among liberal arts students, the general public, and occasionally science educators. Because of their future influence on youth, we examined basic science knowledge and several pseudoscience beliefs among 540 female and 123 male upperclass preservice teachers, comparing them with representative samples of comparably educated American adults. Future teachers resembled national adults on basic science knowledge. Their scores on evolution; creationism; intelligent design; fantastic beasts; magic; and extraterrestrials indices depended on the topic. Exempting science education, preservice teachers rejected evolution, accepting Biblical creation and intelligent design accounts. Sizable minorities "awaited more evidence" about fantastic beasts, magic, or extraterrestrials. Although gender, disciplinary major, grade point average, science knowledge, and two religiosity measures related to beliefs about evolution-creation, these factors were generally unassociated with the other indices. The findings suggest more training is needed for preservice educators in the critical evaluation of material evidence. We also discuss the judicious use of pseudoscience beliefs in such training.

  3. Deep Vadose Zone Treatability Test for the Hanford Central Plateau: Interim Post-Desiccation Monitoring Results

    SciTech Connect

    Truex, Michael J.; Oostrom, Martinus; Strickland, Christopher E.; Johnson, Timothy C.; Johnson, Christian D.; Clayton, Ray E.; Chronister, Glen B.

    2013-09-01

    A field test of desiccation is being conducted as an element of the deep vadose zone treatability test program. Desiccation technology relies on removal of water from a portion of the subsurface such that the resultant low moisture conditions inhibit downward movement of water and dissolved contaminants. Previously, a field test report (Truex et al. 2012a) was prepared describing the active desiccation portion of the test and initial post-desiccation monitoring data. Additional monitoring data have been collected at the field test site during the post-desiccation period and is reported herein along with interpretation with respect to desiccation performance. This is an interim report including about 2 years of post-desiccation monitoring data.

  4. Extrapyramidal Motor Dysfunction and Resultant Orofacial Dystonia Post-Cocaine Abuse: A Clinical Case Study

    ERIC Educational Resources Information Center

    McMicken, Betty L.; Ostergren, Jennifer A.; Vento-Wilson, Margaret

    2010-01-01

    This case study investigated the consequences of cocaine use and resultant extrapyramidal motor dysfunction. The study focused on a female client, post-long-term drug abuse with concomitant untreated head trauma, experiencing extraneous motor movements of the lips, tongue, jaw, and upper and lower extremities. The goals of this study were to (a)…

  5. Equal Learning Does Not Result in Equal Remembering: The Importance of Post-Encoding Processes

    PubMed Central

    Bauer, Patricia J.; Güler, O. Evren; Starr, Rebecca M.; Pathman, Thanujeni

    2015-01-01

    Explanations of variability in long-term recall typically appeal to encoding and/or retrieval processes. However, for well over a century, it has been apparent that for memory traces to be stored successfully, they must undergo a post-encoding process of stabilization and integration. Variability in post-encoding processes is thus a potential source of age-related and individual variance in long-term recall. We examined post-encoding variability in each of two experiments. In each experiment, 20-month-old infants were exposed to novel three-step sequences in each of three encoding conditions: watch only, imitate, and learn to criterion. They were tested for recall after 15 min (as a measure of the success of encoding) and either weeks (1, 2, or 3: Experiment 1) or days (1, 2, or 4: Experiment 2) later. In each experiment, differential relative levels of performance among the conditions were observed at the two tests. The results implicate post-encoding processes are a source of variance in long-term recall. PMID:26207100

  6. Chemical analysis of post explosion samples obtained as a result of model field experiments.

    PubMed

    Borusiewicz, Rafal; Zadora, Grzegorz; Zieba-Palus, Janina

    2013-11-15

    Five different explosives were detonated in a series of field experiments. Each experiment (detonation of the charge of each specific explosive) was repeated three times. The experiments were conducted under controlled conditions, exceeding those of research published so far. Detonated charges were uniform in size and, as far as possible, in shape. The explosives used originated from the same batch. Additionally, the same kind of electric detonators were used. Witness plates (sheets of galvanised steel 100 cm × 90 cm × 0.5 mm) were used to collect post-blast residues in a reproducible way. They were placed relatively close to the charge to minimise the influence of the wind. Samples were collected by systematic swabbing of the surface of the plate by acetone moistened cotton swabs. Samples were packed tight, transferred to the laboratory, and extracted with methanol. Extracts were concentrated by solvent evaporation, cleaned by centrifugation, and analysed using HPLC-DAD. Each extract was analysed three times and the mean value of the amount of the given explosive within the extract was calculated. For each of the explosive materials used the results of the repetition of the experiments proved them to be irreproducible. After each detonation of a specific charge different amounts of given explosives were found in post-blast samples. Also, the intuitively expected relationship between the distance from the charge and amount of post-blast residues were not observed. These results are consistent with previously published results of field experiments. The lack of reproducibility may be explained by differences in efficiency of detonation. The efficiency of a detonation may be influenced even by small differences in the shape of the charge as well as by the position and properties of the detonator. The lack of dependency between the amount of the explosive in the post-blast samples and the distance from the charge may be explained by the fact that during detonation

  7. Corneal collagen crosslinking for corneal ectasia of post-LASIK: one-year results

    PubMed Central

    Li, Gang; Fan, Zheng-Jun; Peng, Xiu-Jun

    2012-01-01

    AIM To evaluate the efficacy and safety of corneal collagen crosslinking (CXL) to prevent the progression of post-laser in situ keratomileusis (LASIK) corneal ectasia. METHODS In a prospective, nonrandomized, single-centre study, CXL was performed in 20 eyes of 11 patients who had LASIK for myopic astigmatism and subsequently developed keratectasia.The procedure included instillation of 0.1% riboflavin-20% dextrane solution 30 minutes before UVA irradiation and every 5 minutes for an additional 30 minutes during irradiation. The eyes were evaluated preoperatively and at 1-, 3-, 6-, and 12-month intervals. The complete ophthalmologic examination comprised uncorrected visual acuity, best spectacle-corrected visual acuity, endothelial cell count, ultrasound pachymetry, corneal topography, and in vivo confocal microscopy. RESULTS CXL appeared to stabilise or partially reverse the progression of post-LASIK corneal ectasia without apparent complication in our cohort. UCVA and BCVA improvements were statistically significant(P<0.05) beyond 12 months after surgery (improvement of 0.07 and 0.13 logMAR at 1 year, respectively). Mean baseline flattest meridian keratometry and mean steepest meridian keratometry reduction (improvement of 2.00 and 1.50 diopters(D), respectively) were statistically significant (P<0.05) at 12 months postoperatively. At 1 year after CXL, mean endothelial cell count did not deteriorate. Mean thinnest cornea pachymetry increased significantly. CONCLUSION The results of the study showed a long-term stability of post-LASIK corneal ectasia after crosslinking without relevant side effects. It seems to be a safe and promising procedure to stop the progression of post-LASIK keratectasia, thereby avoiding or delaying keratoplasty. PMID:22762048

  8. POST ASYMPTOTIC GIANT BRANCH BIPOLAR REFLECTION NEBULAE: RESULT OF DYNAMICAL EJECTION OR SELECTIVE ILLUMINATION?

    SciTech Connect

    Koning, N.; Kwok, Sun; Steffen, W. E-mail: sunkwok@hku.hk

    2013-03-10

    A model for post asymptotic giant branch bipolar reflection nebulae has been constructed based on a pair of evacuated cavities in a spherical dust envelope. Many of the observed features of bipolar nebulae, including filled bipolar lobes, an equatorial torus, searchlight beams, and a bright central light source, can be reproduced. The effects on orientation and dust densities are studied and comparisons with some observed examples are offered. We suggest that many observed properties of bipolar nebulae are the result of optical effects and any physical modeling of these nebulae has to take these factors into consideration.

  9. [The remote post-graduate education in otorhinolaryngology: the first results and further prospects].

    PubMed

    Nosulya, E V; Kosyakov, S Ya; Kim, I A; Piskunov, G Z

    2016-01-01

    The objective of the present work was the retrospective analysis of the efficiency of two courses of remote education of otorhinolaryngologists in the real-time mode based on the results of the on-line questionnaire study. We analyzed the data obtained during the implementation of the pilot project of the remote post-graduate education at the Department of Otorhinolaryngology,Russian Medical Academy of Post-Graduate Education making use of the independent Internet resource for the professional training of otorhinolaryngologists. The two programs of remote education realized in 2012 and 2013 involved 7.9% of all otorhinolaryngologists practicing in the Russian Federation. The fraction of those who passed through all stages of the learning process increased almost two-fold, that is from 10% in 2012 up to 19% in 2013. About 14% of the participants made themselves familiar with all program modules; this result is in agreement with the data obtained in mass on-line remote teaching of the non-medical audience. It is concluded that the results of the present study provide a basis for the elaboration of the remote education programs for the training of specialists not only in otorhinolaryngology but also in other fields of medicine.

  10. Summary of Post Irradiation Examination Results of the AFIP-6 Failure

    SciTech Connect

    Adam Robinson; Daniel M. Wachs; Francine Rice; Danielle Perez

    2011-10-01

    The AFIP-6 test assembly was irradiated for one cycle in the Advanced Test Reactor at Idaho National Laboratory. The experiment was designed to test two monolithic fuel plates at power and burn-ups which bounded the operating conditions of both ATR and HFIR driver fuel. Both plates contain a solid U-Mo fuel foil with a zirconium diffusion barrier between 6061-aluminum cladding plates bonded by hot isostatic pressing. The experiment was designed with an orifice to restrict the coolant flow in order to obtain prototypic coolant temperature conditions. While these coolant temperatures were obtained, flow restriction resulted in low heat transfer coefficients and the failure of the fuel plates. The results from the post irradiation examinations and some observations of the failure mechanisms are outlined herein.

  11. Post-flight test results of acousto-optic modulator devices subjected to space exposure

    NASA Astrophysics Data System (ADS)

    Prasad, Narasimha S.; Trivedi, Sudhir; Rosemeier, Jolanta; Diestler, Mark

    2014-09-01

    The objective of the Materials International Space Station Experiment (MISSE) is to study the performance of novel materials when subjected to the synergistic effects of the harsh space environment for several months. MISSE missions provide an opportunity for developing space qualifiable materials. Several laser and lidar components were sent by NASA Langley Research Center (LaRC) as a part of the MISSE 7 mission. The MISSE 7 module was transported to the international space station (ISS) via STS 129 mission that was launched on Nov 16, 2009. Later, the MISSE 7 modulewas brought back to the earth via the STS 134 that landed on June 1, 2011. The MISSE 7 module that was subjected to exposure in space environment for more than one and a half year included fiber laser, solid-state laser gain materials, detectors, and semiconductor laser diode. Performance testing of these components is now progressing. In this paper, the results of performance testing of a laser diode module sent by NASA Langley Research Center on MISSE 7 mission will be discussed. This paper will present the comparison of pre-flight and post-flight performance of two different COTS acousto-optic modulator devices. Post-flight measurements indicate that these two devices did not undergo any significant performance degradation.

  12. Post-Flight Test Results of Acousto-Optic Modulator Devices Subjected to Space Exposure

    NASA Technical Reports Server (NTRS)

    Prasad, Narasimha S.; Trivedi, Sudhir; Rosemeier, Jolanta; Diestler, Mark

    2014-01-01

    The objective of the Materials International Space Station Experiment (MISSE) is to study the performance of novel materials when subjected to the synergistic effects of the harsh space environment for several months. MISSE missions provide an opportunity for developing space qualifiable materials. Several laser and lidar components were sent by NASA Langley Research Center (LaRC) as a part of the MISSE 7 mission. The MISSE 7 module was transported to the international space station (ISS) via STS 129 mission that was launched on Nov 16, 2009. Later, the MISSE 7 module was brought back to the earth via the STS 134 that landed on June 1, 2011. The MISSE 7 module that was subjected to exposure in a space environment for more than one and a half years included fiber laser, solid-state laser gain materials, detectors, and semiconductor laser diode. Performance testing of these components is now progressing. In this paper, the results of performance testing of a laser diode module sent by NASA Langley Research Center on MISSE 7 mission will be discussed. This paper will present the comparison of pre-flight and post-flight performance of two different COTS acousto-optic modulator (AOM) devices. Post-flight measurements indicate that these two devices did not undergo any significant performance degradation.

  13. Summary of Mode Deactivation Therapy, Cognitive Behavior Therapy and Social Skills Training with Two Year Post Treatment Results

    ERIC Educational Resources Information Center

    Apsche, Jack A.; Bass, Christopher K.; Siv, Alexander M.

    2006-01-01

    This study summarized two treatment research studies and included recidivism data for two years post discharge for group therapy. The study compared Mode deactivation Therapy (MDT), Cognitive Behavior Therapy (CBT), and Social Skills training (SST), results of the MDT series of studies and the two year post-study recidivism data. The data from the…

  14. The post-embryonic development of Remipedia (Crustacea)--additional results and new insights.

    PubMed

    Koenemann, Stefan; Olesen, Jørgen; Alwes, Frederike; Iliffe, Thomas M; Hoenemann, Mario; Ungerer, Petra; Wolff, Carsten; Scholtz, Gerhard

    2009-03-01

    The post-embryonic development of a species of the enigmatic crustacean group Remipedia is described in detail for the first time under various aspects. Applying a molecular approach, we can clearly prove the species identity of the larvae as belonging to Pleomothra apletocheles. We document the cellular level of several larval stages and the differentiation of segments, limbs, and the general body morphology applying the techniques of confocal laser scanning microscopy and scanning electron microscopy. In addition, we document the swimming behavior and the peculiar movements of the naupliar appendages. A comparison of our results with published data on other Crustacea and their larval development tentatively supports ideas about phylogenetic affinities of the Remipedia to the Malacostraca.

  15. Post-processing V&V level II ASC milestone (2360) results.

    SciTech Connect

    Chavez, Elmer; Karelitz, David B.; Brunner, Thomas A.; Trucano, Timothy Guy; Moreland, Kenneth D.; Weirs, V. Gregory; Shead, Timothy M.

    2007-09-01

    The 9/30/2007 ASC Level 2 Post-Processing V&V Milestone (Milestone 2360) contains functionality required by the user community for certain verification and validation tasks. These capabilities include loading of edge and face data on an Exodus mesh, run-time computation of an exact solution to a verification problem, delivery of results data from the server to the client, computation of an integral-based error metric, simultaneous loading of simulation and test data, and comparison of that data using visual and quantitative methods. The capabilities were tested extensively by performing a typical ALEGRA HEDP verification task. In addition, a number of stretch criteria were met including completion of a verification task on a 13 million element mesh.

  16. Advanced Photovoltaic Experiment, S0014: Preliminary Flight Results and Post-Flight Findings

    NASA Technical Reports Server (NTRS)

    Brinker, David J.; Hickey, John R.; Brasted, Donald K.

    1991-01-01

    The Advanced Photovoltaic Experiment (APEX) is an LDEF experiment designed to provide reference solar cell standards for laboratory measurements as well as to investigate the solar spectrum and the effects of long term exposure of solar cells to the LEO environment. Silicon and gallium arsenide solar cells were flown with the appropriate instrumentation to periodically measure cell performance and temperature. The experimental objectives, the design employed to realize these objectives and the solar cells and instrumentation selected for the flight are presented. A discussion of the flight data returned are included. Preliminary results from the post flight analysis of the absolute cavity radiometer, the digital solar angle sensor, and the Barr Associates narrow bandpass optical filters are also presented. The initial findings of work to determine the chemical nature of contamination layers on APEX are also presented.

  17. Challenger STS-17 (41-G) post-flight best estimate trajectory products: Development and summary results

    NASA Technical Reports Server (NTRS)

    Kelly, G. M.; Heck, M. L.; Mcconnell, J. G.; Waters, L. A.; Troutman, P. A.; Findlay, J. T.

    1985-01-01

    Results from the STS-17 (41-G) post-flight products are presented. Operational Instrumentation recorder gaps, coupled with the limited tracking coverage available for this high inclination entry profile, necessitated selection of an anchor epoch for reconstruction corresponding to an unusually low altitude of h approx. 297 kft. The final inertial trajectory obtained, BT17N26/UN=169750N, is discussed in Section I, i.e., relative to the problems encountered with the OI and ACIP recorded data on this Challenger flight. Atmospheric selection, again in view of the ground track displacement from the remote meteorological sites, constituted a major problem area as discussed in Section II. The LAIRS file provided by Langley was adopted, with NOAA data utilized over the lowermost approx. 7 kft. As discussed in Section II, the Extended BET, ST17BET/UN=274885C, suggests a limited upper altitude (H approx. 230 kft) for which meaningful flight extraction can be expected. This is further demonstrated, though not considered a limitation, in Section III wherein summary results from the AEROBET (NJ0333 with NJ0346 as duplicate) are presented. GTFILEs were generated only for the selected IMU (IMU2) and the Rate Gyro Assembly/Accelerometer Assembly data due to the loss of ACIP data. Appendices attached present inputs for the generation of the post-flight products (Appendix A), final residual plots (Appendix B), a two second spaced listing of the relevant parameters from the Extended BET (Appendix C), and an archival section (Appendix D) devoting input (source) and output files and/or physical reels.

  18. Cranberry juice capsules and urinary tract infection post surgery: Results of a randomized trial

    PubMed Central

    Foxman, Betsy; Cronenwett, Ms. Anna E.W.; Spino, Cathie; Berger, Mitchell B.; Morgan, Daniel M.

    2015-01-01

    Objective The risk of urinary tract infection (UTI) among women undergoing elective gynecologic surgery where a catheter is placed is high: 10 to 64% following catheter removal. We conducted the first randomized, double-blind, placebo-controlled trial of the therapeutic efficacy of cranberry juice capsules in preventing UTI post surgery. Study Design We recruited patients from a single hospital between August 2011 and January 2013. Eligible participants were undergoing elective gynecologic surgery that did not involve a fistula repair or vaginal mesh removal. 160 patients were randomized and received two cranberry juice capsules two times a day, equivalent to two 8-ounce servings of cranberry juice, for 6 weeks after surgery, or matching placebo. The primary endpoint was the proportion of participants who experienced clinically-diagnosed and treated UTI with or without positive urine culture. Kaplan-Meier plots and logrank tests compared the two treatment groups. Results The occurrence of UTI was significantly lower in the cranberry treatment group compared to the placebo group (15/80 (19%) versus 30/80 (38%); OR=0.38; 95% CI: 0.19, 0.79; p=0.008). After adjustment for known confounders, including frequency of intermittent self-catheterization in the post- operative period, the protective effects of cranberry remained (OR=0.42; 95% CI: 0.18, 0.94). There were no treatment differences in the incidence of adverse events; including gastrointestinal upset (56% vs. 61% for cranberry vs. placebo). Conclusions Among women undergoing elective benign gynecologic surgery involving urinary catheterization, use of cranberry extract tablets during the postoperative period reduced the rate of UTI by half. PMID:25882919

  19. Post-mortem forensic neuroimaging: correlation of MSCT and MRI findings with autopsy results.

    PubMed

    Yen, Kathrin; Lövblad, Karl-Olof; Scheurer, Eva; Ozdoba, Christoph; Thali, Michael J; Aghayev, Emin; Jackowski, Christian; Anon, Javier; Frickey, Nathalie; Zwygart, Karin; Weis, Joachim; Dirnhofer, Richard

    2007-11-15

    Multislice-computed tomography (MSCT) and magnetic resonance imaging (MRI) are increasingly used for forensic purposes. Based on broad experience in clinical neuroimaging, post-mortem MSCT and MRI were performed in 57 forensic cases with the goal to evaluate the radiological methods concerning their usability for forensic head and brain examination. An experienced clinical radiologist evaluated the imaging data. The results were compared to the autopsy findings that served as the gold standard with regard to common forensic neurotrauma findings such as skull fractures, soft tissue lesions of the scalp, various forms of intracranial hemorrhage or signs of increased brain pressure. The sensitivity of the imaging methods ranged from 100% (e.g., heat-induced alterations, intracranial gas) to zero (e.g., mediobasal impression marks as a sign of increased brain pressure, plaques jaunes). The agreement between MRI and CT was 69%. The radiological methods prevalently failed in the detection of lesions smaller than 3mm of size, whereas they were generally satisfactory concerning the evaluation of intracranial hemorrhage. Due to its advanced 2D and 3D post-processing possibilities, CT in particular possessed certain advantages in comparison with autopsy with regard to forensic reconstruction. MRI showed forensically relevant findings not seen during autopsy in several cases. The partly limited sensitivity of imaging that was observed in this retrospective study was based on several factors: besides general technical limitations it became apparent that clinical radiologists require a sound basic forensic background in order to detect specific signs. Focused teaching sessions will be essential to improve the outcome in future examinations. On the other hand, the autopsy protocols should be further standardized to allow an exact comparison of imaging and autopsy data. In consideration of these facts, MRI and CT have the power to play an important role in future forensic

  20. Equal Learning Does Not Result in Equal Remembering: The Importance of Post-Encoding Processes

    ERIC Educational Resources Information Center

    Bauer, Patricia J.; Guler, O. Evren; Starr, Rebecca M.; Pathman, Thanujeni

    2011-01-01

    Explanations of variability in long-term recall typically appeal to encoding and/or retrieval processes. However, for well over a century, it has been apparent that for memory traces to be stored successfully, they must undergo a post-encoding process of stabilization and integration. Variability in post-encoding processes is thus a potential…

  1. Excellent long-term results with iliac stenting in local anesthesia for post-thrombotic syndrome

    PubMed Central

    Just, Sven; Foegh, Pia; Baekgaard, Niels

    2015-01-01

    Background Only 20% of iliac veins will recanalize on anticoagulation (AC) treatment alone and may, therefore, develop venous obstruction after iliofemoral deep venous thrombosis (DVT). A considerable number of these patients will suffer from post-thrombotic syndrome (PTS) leading to impaired quality of life in more than 50%. Endovascular treatment for iliac vein obstruction using stents is known to alleviate PTS symptoms in selected patients. Purpose To report the Danish long-term results of endovascular treatment with iliac stenting. Material and Methods From 2000 to 2013 consecutive patients were evaluated and 19 patients with severe venous claudication were identified and subsequently underwent angioplasty and stenting. AC treatment was prescribed for 6 months, and knee-high class II compression stocking recommended for 1 year. Scheduled follow-up was done in the outpatient clinic at 6 weeks, 3 months, and annually thereafter. Results Nineteen patients, all women, all with left-sided iliac vein obstruction, and all with severe PTS symptoms were included. The median follow-up time was 81 months (range, 1–146 months; mean, 69 months). Primary patency rate of the inserted iliac stent was 89% (17/19) and 16 patients (84 %) had almost or total symptom relief at follow-up. Conclusion Endovascular stenting of iliac obstruction in local anesthesia is minimally invasive and shows excellent long-term outcomes for patients suffering from PTS. PMID:26445677

  2. Fish Oil and Post-Operative Atrial Fibrillation – Results of the Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation (OPERA) Trial

    PubMed Central

    Mozaffarian, Dariush; Marchioli, Roberto; Macchia, Alejandro; Silletta, Maria G.; Ferrazzi, Paolo; Gardner, Timothy J.; Latini, Roberto; Libby, Peter; Lombardi, Federico; O’Gara, Patrick T.; Page, Richard L.; Tavazzi, Luigi; Tognoni, Gianni

    2013-01-01

    Context Post-operative atrial fibrillation/flutter (AF) is one of the most common complications of cardiac surgery and significantly increases morbidity and healthcare utilization. A few small trials have evaluated whether long-chain n-3-polyunsaturated fatty acids (PUFA) reduce post-op AF, with mixed results. Objective To determine whether peri-operative n-3-PUFA supplementation reduces post-op AF. Design Randomized, double-blind, placebo-controlled, multinational, clinical trial. Patients A total of 1,516 patients scheduled for cardiac surgery across 28 centers in the US, Italy, and Argentina, enrolled between Aug 2010 and Jun 2012. Inclusion criteria were broad; the main exclusions were regular use of fish oil or absence of sinus rhythm at enrollment. Forty-eight percent of screened patients and 94% of eligible patients were enrolled. Intervention Patients were randomized to receive fish oil (1 g capsules containing ≥840 mg n-3-PUFA as ethyl esters) or placebo, with pre-operative loading of 10g over 3-5 days (or 8g over 2 days) followed post-operatively by 2g/d until hospital discharge or post-op day10, whichever first. Main Outcome Measures The primary endpoint was occurrence of post-op AF >30 sec. We also evaluated post-op AF lasting >1hr, resulting in symptoms, or treated with cardioversion; other secondary post-op AF endpoints; other tachyarrhythmias; hospital utilization; and major adverse cardiovascular events, 30-day mortality, bleeding, and other adverse events. All endpoints and analyses plans were prespecified. Results At enrollment, mean±SD age was 64±13 years, 72.2% were male, and 51.8% had planned valvular surgery. The primary endpoint occurred in 233 (30.7%) and 227 (30.0%) patients assigned to placebo and n-3-PUFA, respectively (OR=0.96, 95%CI=0.77-1.20; P=0.74). None of the secondary endpoints were significantly different, including post-op AF that was sustained, symptomatic, or treated (n=231 [30.5%] vs. n=224 [29.6%], P=0.70) or number of

  3. Post-flight test results of seed laser module subjected to space exposure

    NASA Astrophysics Data System (ADS)

    Prasad, Narasimha S.

    2013-09-01

    The objective of the Materials International Space Station Experiment (MISSE) is to study the performance of novel materials when subjected to the synergistic effects of the harsh space environment for several months. MISSE missions provide an opportunity for developing space qualifiable materials. Several laser and lidar components were sent by NASA Langley Research Center (LaRC) as a part of the MISSE 7 mission. The MISSE 7 module was transported to the international space station (ISS) via STS 129 mission that was launched on Nov 16, 2009. Later, the MISSE 7 module was brought back to the earth via the STS 134 that landed on June 1, 2011. The MISSE 7 module that was subjected to exposure in space environment for more than one and a half year included fiber laser, solid-state laser gain materials, detectors, and semiconductor laser diode. Performance testing of these components is now progressing. In this paper, the results of performance testing of a laser diode module sent by NASA Langley Research Center on MISSE 7 mission will be discussed. This paper will present the comparison of pre-flight and post-flight performance curves and discuss the effect of space exposure on the laser diode module. Preliminary findings on output power measurements show that the COTS laser diode characteristics did not undergo any significant performance degradation.

  4. Post-impact climate conditions on early Mars: preliminary results from GCM simulations

    NASA Astrophysics Data System (ADS)

    Steakley, Kathryn; Murphy, Jim; Kahre, Melinda A.; Haberle, Robert

    2016-10-01

    Observations imply that liquid water was stable on Mars' surface during the late Noachian/early Hesperian era, with valley networks forming roughly 3.5-3.75 billion years ago, possibly from precipitation and runoff (Fassett & Head 2008, Icarus 195, 61; Hynek et al., 2010, JGR Planets, 115, E09008). Climate models, however, struggle to reproduce such warm conditions (Forget et al., 2013, Icarus 21, 81). Volcanism and impacts have been suggested as mechanisms of either inducing a warm and wet environment or causing local melting in a cold and wet environment. Comets and asteroids are capable of injecting into the atmosphere both kinetic energy from the impact and water from the object itself and from vaporized surface and subsurface ice. Segura et al. (2008, JGR Planets 113, E11007) find using a 1-D atmospheric model that significant rainfall and periods of above-freezing temperatures lasting months to years can follow impacts of objects between 30 and 100 km in diameter. We revisit this work utilizing a 3-D global climate model (GCM) to consider the effects of dynamics, topography, global surface ice variations, etc. We present preliminary results from the NASA ARC Mars GCM investigating global temperature and precipitation behavior in a post-impact, early Mars environment.

  5. Impact of the post fire management in some soil chemical properties. First results.

    NASA Astrophysics Data System (ADS)

    Francos, Marcos; Pereira, Paulo; Alcañiz, Meritxell; Úbeda, Xavi

    2016-04-01

    Post-fire management after severe wildfires has impact on soil properties. In Mediterranean environments management of fire affected areas is a common practice. This intervention may change soil chemical properties of the soil such as major cations. The aim of this work is to study the impact of different types of forest management in soil extractable calcium, magnesium, sodium and potassium after a severe wildfire. The study area is located in Ódena (Catalonia, Spain). The wildfire occurred at July 27th of 2015 and burned 1235 ha. After the fire an experimental plot was designed 9 plots with 2x2 meters (4 square meters). The different managements were: a) clear-cuted area and wood removed, b) no treatment); and c) clear-cutted. The results of the first sampling showed significant differences among all treatments in extractable calcium, sodium and potassium. The amount of these extractable elements was high in clear-cutted treatment in comparison to the others. No differences were identified in extractable magnesium. Overall, in the immediate period after the fire, burned area management, changed the studied soil properties. We are currently studying the evolution of this soil properties in these plots with the time

  6. Pulsations driven by the ɛ-mechanism in post-merger remnants: First results

    NASA Astrophysics Data System (ADS)

    Miller Bertolami, M. M.; Córsico, A. H.; Zhang, X.; Althaus, L. G.; Jeffery, C. S.

    2013-03-01

    Helium-rich subdwarfs are a rare subclass of hot subdwarf stars which constitute a small and inhomogeneous group showing varying degrees of helium enrichment. Only one star, LS IV °14 116 has been found to show multiperiodic luminosity variations. The variability of LS IV °14 116 has been explained as the consequence of nonradial g-mode oscillations, whose excitation is difficult to understand within the frame of the standard κ-mechanism driving pulsations in sdBV stars. In a recent study, we have proposed that the pulsations of LS IV °14 116 might be driven through the ɛ-mechanism acting in unstable He-burning zones in the interior of the star, that appear before the quiescent He-burning phase. One of the few accepted scenarios for the formation of He-rich subdwarfs is the merger of two He-core white dwarfs. As part of this project, we present a study of the ɛ-mechanism in post-merger remnants, and discuss the results in the light of the pulsations exhibited by LS IV °14 116.

  7. Results from pre- and post- tests of professional development astronomy workshops for teachers in Peru

    NASA Astrophysics Data System (ADS)

    Deustua, Susana; Ros, Rosa

    2015-08-01

    Since 2009, the Network for Astronomy School Education (NASE) has held 55+ workshops in countries in Asia, Africa, Europe and Latin America, training more than 1200 teachers and potentially reaching one million or more students. Like modern professional development programs, NASE’s emphasis is on interactive, hands-on learning. However, our emphasis is on “low-tech” tools that are readily available, and, inexpensive. Teachers are led through a series of activities that cover a wide range of topics in astronomy, more or less equivalent to that covered in the typical 1st year astronomy course in US colleges.In 2014 we adopted the Astronomy Diagnostic Test as pre- and post- workshop tests to guage the change in teachers’ knowledge as a result of participation in this intervention. In this paper we discuss the first results using the Astronomy Diagnostic Test in astronomy workshops in Peru during March 2014 and February 2015. NASE workskhops were held at the facilities of the Observatorio de Radio de Sicaya of the Instituto Geofisico del Peru, in Chupaca, a farming community approximately 20 km from the Andean city, Huancayo. Sponsors of the Chupaca workshop were the IGP, NASE and the UGEL (regional school district). The second workshop was held at the University of Ica, in the coastal city of Ica, 250 km south of Lima, sponsored by the Instituto Geofisico del Peru and the University, and the 3rd workshop in Lima.We will discuss our results, which for the most part do indeed show a positive change in knowledge, but in a couple of areas the change is either null or negative.

  8. An education initiative concerning lead in an Arkansas community: results from pre- and post-surveys.

    PubMed

    Ferguson, Alesia; Gilkey, Barbara; Kern, David; Jasmine, Davis

    2012-06-01

    The Arkansas People Participating in Lead Education (APPLE) Program is a collaborative effort between six Arkansas state, national and community organizations to provide lead awareness, training, and municipal legislation to needy communities in Arkansas. Under this program, APPLE organized and hosted well-designed, hands-on, and effective "call to action" lead awareness workshops for parents and community members in 10 needy communities over a 2 year period. Pre- and post-surveys were given to community members to access knowledge, attitudes and effectiveness of lead workshop activities, with demographic and another 13 and 11 questions on pre- and post-surveys, respectively. There were 709 adult attendees across the 10 workshop (Many children also attended.), with 460 completing pre-surveys, and 199 completed post-survey. Post-surveys were limited to four cities. The majority of those who completed surveys were African-American, reported as 78% on pre-surveys, with the majority also being parents (61%) and females. Although, 71% reported knowing that lead paint was bad for their health, more than 60% reported knowing little about lead exposure, and another 25% did not know the age of their residence. On the post-surveys, the majority of respondents found the workshop to be pleasant and informative (98%), while 45% had changed something in their lives to prevent lead exposure for a child and another 53% planned to make a change to prevent lead exposure for a child.

  9. English Proficiency Requirements at BC Post-Secondary Institutions: Challenges Posed for Students. Research Results

    ERIC Educational Resources Information Center

    Cooke, Jim

    2011-01-01

    This newsletter presents key observations from a review of BC post-secondary institutional websites undertaken to assess any differences in admission requirements for entry into standard First Year English courses and in institutional English admission requirements. Recommendations are made on possible actions that could be taken to clarify…

  10. Synthesising empirical results to improve predictions of post-wildfire runoff and erosion response

    USGS Publications Warehouse

    Shakesby, Richard A.; Moody, John A.; Martin, Deborah A.; Robichaud, Peter R.

    2016-01-01

    Advances in research into wildfire impacts on runoff and erosion have demonstrated increasing complexity of controlling factors and responses, which, combined with changing fire frequency, present challenges for modellers. We convened a conference attended by experts and practitioners in post-wildfire impacts, meteorology and related research, including modelling, to focus on priority research issues. The aim was to improve our understanding of controls and responses and the predictive capabilities of models. This conference led to the eight selected papers in this special issue. They address aspects of the distinctiveness in the controls and responses among wildfire regions, spatiotemporal rainfall variability, infiltration, runoff connectivity, debris flow formation and modelling applications. Here we summarise key findings from these papers and evaluate their contribution to improving understanding and prediction of post-wildfire runoff and erosion under changes in climate, human intervention and population pressure on wildfire-prone areas.

  11. DNA methylation results depend on DNA integrity—role of post mortem interval

    PubMed Central

    Rhein, Mathias; Hagemeier, Lars; Klintschar, Michael; Muschler, Marc; Bleich, Stefan; Frieling, Helge

    2015-01-01

    Major questions of neurological and psychiatric mechanisms involve the brain functions on a molecular level and cannot be easily addressed due to limitations in access to tissue samples. Post mortem studies are able to partly bridge the gap between brain tissue research retrieved from animal trials and the information derived from peripheral analysis (e.g., measurements in blood cells) in patients. Here, we wanted to know how fast DNA degradation is progressing under controlled conditions in order to define thresholds for tissue quality to be used in respective trials. Our focus was on the applicability of partly degraded samples for bisulfite sequencing and the determination of simple means to define cut-off values. After opening the brain cavity, we kept two consecutive pig skulls at ambient temperature (19–21°C) and removed cortex tissue up to a post mortem interval (PMI) of 120 h. We calculated the percentage of degradation on DNA gel electrophoresis of brain DNA to estimate quality and relate this estimation spectrum to the quality of human post mortem control samples. Functional DNA quality was investigated by bisulfite sequencing of two functionally relevant genes for either the serotonin receptor 5 (SLC6A4) or aldehyde dehydrogenase 2 (ALDH2). Testing our approach in a heterogeneous collective of human blood and brain samples, we demonstrate integrity of measurement quality below the threshold of 72 h PMI. While sequencing technically worked for all timepoints irrespective of conceivable DNA degradation, there is a good correlation between variance of methylation to degradation levels documented in the gel (R2 = 0.4311, p = 0.0392) for advancing post mortem intervals (PMI). This otherwise elusive phenomenon is an important prerequisite for the interpretation and evaluation of samples prior to in-depth processing via an affordable and easy assay to estimate identical sample quality and thereby comparable methylation measurements. PMID:26042147

  12. Post-Traumatic Stress Disorder in Children as a Result of Violence: A Review of Current Literature.

    ERIC Educational Resources Information Center

    Karcher, Christopher Robb

    This review of research on post-traumatic stress disorder (PTSD) in children resulting from human violence focuses on methodological issues, types of violence, treatment issues, and directions for future research. Literature reviewed is predominantly that published since 1986. An introduction offers background information and examines the…

  13. Post-irradiation Examination of the AGR-1 Experiment: Plans and Preliminary Results

    SciTech Connect

    Paul Demkowicz

    2001-10-01

    Abstract – The AGR-1 irradiation experiment contains seventy-two individual cylindrical fuel compacts (25 mm long x 12.5 mm diameter) each containing approximately 4100 TRISO-coated uranium oxycarbide fuel particles. The experiment accumulated 620 effective full power days in the Advanced Test Reactor at the Idaho National Laboratory with peak burnups exceeding 19% FIMA. An extensive post-irradiation examination campaign will be performed on the AGR-1 fuel in order to characterize the irradiated fuel properties, assess the in-pile fuel performance in terms of coating integrity and fission metals release, and determine the fission product retention behavior during high temperature accident testing. PIE experiments will include dimensional measurements of fuel and irradiated graphite, burnup measurements, assessment of fission metals release during irradiation, evaluation of coating integrity using the leach-burn-leach technique, microscopic examination of kernel and coating microstructures, and accident testing of the fuel in helium at temperatures up to 1800°C. Activities completed to date include opening of the irradiated capsules, measurement of fuel dimensions, and gamma spectrometry of selected fuel compacts.

  14. HST image restoration: A comparison of pre- and post-servicing mission results

    NASA Technical Reports Server (NTRS)

    Hanisch, R. J.; Mo, J.

    1992-01-01

    A variety of image restoration techniques (e.g., Wiener filter, Lucy-Richardson, MEM) have been applied quite successfully to the aberrated HST images. The HST servicing mission (scheduled for late 1993 or early 1994) will install a corrective optics system (COSTAR) for the Faint Object Camera and spectrographs and replace the Wide Field/Planetary Camera with a second generation instrument (WF/PC-II) having its own corrective elements. The image quality is expected to be improved substantially with these new instruments. What then is the role of image restoration for the HST in the long term? Through a series of numerical experiments using model point-spread functions for both aberrated and unaberrated optics, we find that substantial improvements in image resolution can be obtained for post-servicing mission data using the same or similar algorithms as being employed now to correct aberrated images. Included in our investigations are studies of the photometric integrity of the restoration algorithms and explicit models for HST pointing errors (spacecraft jitter).

  15. LDEF Space Plasma-High Voltage Drainage Experiment post-flight results

    NASA Technical Reports Server (NTRS)

    Yaung, J. Y.; Blakkolb, B. K.; Wong, W. C.; Ryan, L. E.; Schurig, H. J.; Taylor, W. W. L.

    1993-01-01

    The Space Plasma-High Voltage Drainage Experiment (SP-HVDE) was comprised of two identical experimental trays. With one tray located on the leading (ram facing, B10) edge and the other located on the trailing (wake facing, D4) edge of the Long Duration Exposure Facility (LDEF), it was possible to directly compare the effects of ram and wake spacecraft environments on charged dielectric materials. Six arrays of Kapton dielectric samples of 2 mil, 3 mil, and 5 mil thicknesses maintained at +/- 300, +/- 500, and +/- 1000 voltage bias formed the experimental matrix of each tray. In addition, each tray carried two solar cell strings, one biased at +300 volts and the other at -300 volts, to study current leakage from High Voltage Solar Arrays (HVSA). The SP-HVDE provides the first direct, long-term, in-flight measurements of average leakage current through dielectric materials under electric stress. The experiment also yields information on the long term stability of the bulk dielectric properties of such materials. Data and findings of the SP-HVDE are an extension of those from shorter term flight experiments such as the PIX-1 (Plasma Interaction Experiment) and PIX-2 and are therefore valuable in the design and evaluation of long-lived space systems with high voltage systems exposed to the low earth orbital environment. A summary of the SP-HVDE post flight analysis final report delivered to the LDEF Project Office under contract to the National Aeronautics and Space Administration is presented.

  16. AGR-1 Fuel Compact 6-3-2 Post-Irradiation Examination Results

    SciTech Connect

    Paul demkowicz; jason Harp; Scott Ploger

    2012-12-01

    Destructive post-irradiation examination was performed on fuel Compact 6-3-2, which was irradiated in the AGR-1 experiment to a final compact average burnup of 11.3% FIMA and a time-average, volume-average temperature of 1070°C. The analysis of this compact was focused on characterizing the extent of fission product release from the particles and examining particles to determine the condition of the kernels and coating layers. The work included deconsolidation of the compact and leach-burn-leach analysis, visual inspection and gamma counting of individual particles, measurement of fuel burnup by several methods, metallurgical preparation of selected particles, and examination of particle cross-sections with optical microscopy. A single particle with a defective SiC layer was identified during deconsolidation-leach-burn-leach analysis, which is in agreement with previous measurements showing elevated cesium in the Capsule 6 graphite fuel holder associated with this fuel compact. The fraction of the compact europium inventory released from the particles and retained in the matrix was relatively high (approximately 6E-3), indicating release from intact particle coatings. The Ag-110m inventory in individual particles exhibited a very broad distribution, with some particles retaining =80% of the predicted inventory and others retaining less than 25%. The average degree of Ag-110m retention in 60 gamma counted particles was approximately 50%. This elevated silver release is in agreement with analysis of silver on the Capsule 6 components, which indicated an average release of 38% of the Capsule 6 inventory from the fuel compacts. In spite of the relatively high degree of silver release from the particles, virtually none of the Ag-110m released was found in the compact matrix, and presumably migrated out of the compact and was deposited on the irradiation capsule components. Release of all other fission products from the particles appears to be less than a single

  17. Post-ischemic salubrinal treatment results in a neuroprotective role in global cerebral ischemia.

    PubMed

    Anuncibay-Soto, Berta; Pérez-Rodríguez, Diego; Santos-Galdiano, María; Font, Enrique; Regueiro-Purriños, Marta; Fernández-López, Arsenio

    2016-07-01

    This study describes the neuroprotective effect of treatment with salubrinal 1 and 24 h following 15 min of ischemia in a two-vessel occlusion model of global cerebral ischemia. The purpose of this study was to determine if salubrinal, an enhancer of the unfolded protein response, reduces the neural damage modulating the inflammatory response. The study was performed in CA1 and CA3 hippocampal areas as well as in the cerebral cortex whose different vulnerability to ischemic damage is widely described. Characterization of proteins was made by western blot, immunofluorescence, and ELISA, whereas mRNA levels were measured by Quantitative PCR. The salubrinal treatment decreased the cell demise in CA1 at 7 days as well as the levels of matrix metalloprotease 9 (MMP-9) in CA1 and cerebral cortex at 48 h and ICAM-1 and VCAM-1 cell adhesion molecules. However, increases in tumor necrosis factor α and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) inflammatory markers were observed at 24 h. Glial fibrillary acidic protein levels were not modified by salubrinal treatment in CA1 and cerebral cortex. We describe a neuroprotective effect of the post-ischemic treatment with salubrinal, measured as a decrease both in CA1 cell demise and in the blood-brain barrier impairment. We hypothesize that the ability of salubrinal to counteract the CA1 cell demise is because of a reduced ability of this structure to elicit unfolded protein response which would account for its greater ischemic vulnerability. Data of both treated and non-treated animals suggest that the neurovascular unit present a structure-dependent response to ischemia and a different course time for CA1/cerebral cortex compared with CA3. Finally, our study reveals a high responsiveness of endothelial cells to salubrinal in contrast to the limited responsiveness of astrocytes. The alleviation of ER stress by enhancing UPR with salubrinal treatment reduces the ischemic damage. This effect

  18. Post-ischemic salubrinal treatment results in a neuroprotective role in global cerebral ischemia.

    PubMed

    Anuncibay-Soto, Berta; Pérez-Rodríguez, Diego; Santos-Galdiano, María; Font, Enrique; Regueiro-Purriños, Marta; Fernández-López, Arsenio

    2016-07-01

    This study describes the neuroprotective effect of treatment with salubrinal 1 and 24 h following 15 min of ischemia in a two-vessel occlusion model of global cerebral ischemia. The purpose of this study was to determine if salubrinal, an enhancer of the unfolded protein response, reduces the neural damage modulating the inflammatory response. The study was performed in CA1 and CA3 hippocampal areas as well as in the cerebral cortex whose different vulnerability to ischemic damage is widely described. Characterization of proteins was made by western blot, immunofluorescence, and ELISA, whereas mRNA levels were measured by Quantitative PCR. The salubrinal treatment decreased the cell demise in CA1 at 7 days as well as the levels of matrix metalloprotease 9 (MMP-9) in CA1 and cerebral cortex at 48 h and ICAM-1 and VCAM-1 cell adhesion molecules. However, increases in tumor necrosis factor α and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) inflammatory markers were observed at 24 h. Glial fibrillary acidic protein levels were not modified by salubrinal treatment in CA1 and cerebral cortex. We describe a neuroprotective effect of the post-ischemic treatment with salubrinal, measured as a decrease both in CA1 cell demise and in the blood-brain barrier impairment. We hypothesize that the ability of salubrinal to counteract the CA1 cell demise is because of a reduced ability of this structure to elicit unfolded protein response which would account for its greater ischemic vulnerability. Data of both treated and non-treated animals suggest that the neurovascular unit present a structure-dependent response to ischemia and a different course time for CA1/cerebral cortex compared with CA3. Finally, our study reveals a high responsiveness of endothelial cells to salubrinal in contrast to the limited responsiveness of astrocytes. The alleviation of ER stress by enhancing UPR with salubrinal treatment reduces the ischemic damage. This effect

  19. Post-Knowledge of Results Delay: Effects of Interpolated Activity on Learning and Performance.

    ERIC Educational Resources Information Center

    Benedetti, Carol; McCullagh, Penny

    1987-01-01

    Experimental evidence strongly supports the assumption that knowledge of results (KR) is necessary for learning to occur. This study compares the effects of KR or no-KR with the effects of an interpolated verbal activity on learning and performance of a timed motor task. Results are presented. (Author/MT)

  20. Communicating Results in Post-Belmont Era Biomonitoring Studies: Lessons from Genetics and Neuroimaging Research

    PubMed Central

    Morello-Frosch, Rachel; Varshavsky, Julia; Liboiron, Max; Brown, Phil; Brody, Julia G.

    2014-01-01

    Background Biomonitoring is a critical tool to assess the effects of chemicals on health, as scientists seek to better characterize life-course exposures from diverse environments. This trend, coupled with increased institutional support for community-engaged environmental health research, challenge established ethical norms related to biomonitoring results communication and data sharing between scientists, study participants, and their wider communities. Methods Through a literature review, participant observation at workshops, and interviews, we examine ethical tensions related to reporting individual data from chemical biomonitoring studies by drawing relevant lessons from the genetics and neuroimaging fields. Results In all three fields ethical debates about whether/how to report-back results to study participants are precipitated by two trends. First, changes in analytical methods have made more data accessible to stakeholders. For biomonitoring, improved techniques enable detection of more chemicals at lower levels, and diverse groups of scientists and health advocates now conduct exposure studies. Similarly, innovations in genetics have catalyzed large-scale projects and broadened the scope of who has access to genetic information. Second, increasing public interest in personal medical information has compelled imaging researchers to address demands by participants to know their personal data, despite uncertainties about their clinical significance. Four ethical arenas relevant to biomonitoring results communication emerged from our review: Tensions between participants’ right-to-know their personal results versus their ability or right-to-act to protect their health; whether and how to report incidental findings; informed consent in biobanking; and open-access data sharing. Conclusion Ethically engaging participants in biomonitoring studies requires consideration of several issues, including scientific uncertainty about health implications and exposure

  1. Analytical results for post-buckling behaviour of plates in compression and in shear

    NASA Technical Reports Server (NTRS)

    Stein, M.

    1985-01-01

    The postbuckling behavior of long rectangular isotropic and orthotropic plates is determined. By assuming trigonometric functions in one direction, the nonlinear partial differential equations of von Karman large deflection plate theory are converted into nonlinear ordinary differential equations. The ordinary differential equations are solved numerically using an available boundary value problem solver which makes use of Newton's method. Results for longitudinal compression show different postbuckling behavior between isotropic and orthotropic plates. Results for shear show that change in inplane edge constraints can cause large change in postbuckling stiffness.

  2. Adolescent traumatic stress experience results in less robust conditioned fear and post-extinction fear cue responses in adult rats.

    PubMed

    Moore, Nicole L T; Gauchan, Sangeeta; Genovese, Raymond F

    2014-05-01

    Early exposure to a traumatic event may produce lasting effects throughout the lifespan. Traumatic stress during adolescence may deliver a distinct developmental insult compared with more-often studied neonatal or juvenile traumatic stress paradigms. The present study describes the lasting effects of adolescent traumatic stress upon adulthood fear conditioning. Adolescent rats were exposed to a traumatic stressor (underwater trauma, UWT), then underwent fear conditioning during adulthood. Fear extinction was tested over five conditioned suppression extinction sessions three weeks later. The efficacies of two potential extinction-enhancing compounds, endocannabinoid reuptake inhibitor AM404 (10mg/kg) and M1 muscarinic positive allosteric modulator BQCA (10mg/kg), were also assessed. Finally, post-extinction fear responses were examined using a fear cue (light) as a prepulse stimulus. Rats traumatically stressed during adolescence showed blunted conditioned suppression on day 1 of extinction training, and AM404 reversed this effect. Post-extinction startle testing showed that fear conditioning eliminates prepulse inhibition to the light cue. Startle potentiation was observed only in rats without adolescent UWT exposure. AM404 and BQCA both ameliorated this startle potentiation, while BQCA increased startle in the UWT group. These results suggest that exposure to a traumatic stressor during adolescence alters developmental outcomes related to stress response and fear extinction compared to rats without adolescent traumatic stress exposure, blunting the adulthood fear response and reducing residual post-extinction fear expression. Efficacy of pharmacological interventions may also vary as a factor of developmental traumatic stress exposure.

  3. [Results of a post-marketing surveillance of meropenem administered over 2 g/day for serious infectious diseases].

    PubMed

    Wakisaka, Koji; Tani, Shunsuke; Ishibashi, Kazuo; Nukui, Kazuhiko; Nagao, Munehiko

    2015-10-01

    The post-marketing surveillance of meropenem (Meropen®) administered over 2g/day for serious infectious diseases was conducted between August 2011 and June 2013 to evaluate safety and efficacy under actual clinical use. There were 382 and 322 evaluable cases for safety and efficacy respectively, of 399 case cards collected from 87 institutions. In safety analysis, the incidence of adverse drug reactions (ADRs) associated with use of meropenem (including abnormal laboratory findings) was 19.1% (73/382 cases), and the main ADRs were hepatic function abnormal, aspartate aminotransferase increased, alanine aminotransferase increased, liver disorder, and diarrhoea, which were similar to these observed in the post-marketing surveillances of meropenem conducted before. In efficacy analysis, the efficacy was 73.6% (237/322 cases), which is as same as 71.4% (3214/4504 cases) of post-marketing surveillance of meropenem conducted after first approval under 2 g/day for infectious diseases. These results confirmed meropenem (Meropen®) is one of the useful antimicrobial agents for serious infectious diseases.

  4. Integrating Computer Algebra Systems in Post-Secondary Mathematics Education: Preliminary Results of a Literature Review

    ERIC Educational Resources Information Center

    Buteau, Chantal; Marshall, Neil; Jarvis, Daniel; Lavicza, Zsolt

    2010-01-01

    We present results of a literature review pilot study (326 papers) regarding the use of Computer Algebra Systems (CAS) in tertiary mathematics education. Several themes that have emerged from the review are discussed: diverse uses of CAS, benefits to student learning, issues of integration and mathematics learning, common and innovative usage of…

  5. Employee Post-Training Behaviour and Performance: Evaluating the Results of the Training Process

    ERIC Educational Resources Information Center

    Diamantidis, Anastasios D.; Chatzoglou, Prodromos D.

    2014-01-01

    Despite the fact that firms invest in training, there is considerable evidence to show that training programmes often fail to achieve the intended result of improving worker and organization performance. The purpose of this paper is to examine the medium- to long-term effects of training programmes on firms by means of an integrated research model…

  6. Advanced photovoltaic experiment, S0014: Preliminary flight results and post-flight findings

    NASA Technical Reports Server (NTRS)

    Brinker, David J.; Hickey, John R.; Scheiman, David A.

    1992-01-01

    The Advanced Photovoltaic Experiment is a Long Duration Exposure Facility (LDEF) experiment originally designed to provide reference solar cell standards for laboratory measurements as well as to investigate the solar spectrum and the effects of long term exposure of space solar cells to the low earth orbit (LEO) environment. The experiment functioned on-orbit as designed, successfully measuring and recording cell performance and solar insolation data over the first 325 days. The objectives and design of the experiment are presented as well as the preliminary flight results and postflight findings.

  7. SDP Herschel/HiFi results from post-AGB sources

    NASA Astrophysics Data System (ADS)

    Alcolea Jimanez, J.; Bujarrabal, V.; Soria-Ruiz, R.; Planesas, P.; Cernicharo, J.; Decin, L.; Dominik, C.; Justtanont, K.; de Koter, A.; Marston, A. P.; Melnick, G.; Menten, K. M.; Neufeld, D.; Olofsson, H.; Pulecka, M.; Schmidt, M.; Schoeier, F. L.; Szczerba, C.; Teyssier, D.; Waters, L. B. F. M.; Quintana-Lacaci, G.; Guesten, R.

    The first Herschel/HiFi data on pPNe and young PNe are being obtained, providing, for the first time, systematic observations of high-excitation molecular lines from these sources with high spectral resolution. The telescope and all telescopes sub-systems are performing as expected, and so the data are of very good quality. The high spectral resolution provided by the heterodyne detection technique allows the detection of spectra of high velocity resolution (always better than 1 km/s), in which the different dynamical components of the nebulae can be clearly separated and identified. This data allows, for the first time, systematically study of the warm molecular component in these objects, including in particular the study of thermal lines of water vapor, which of course cannot be done from the ground. In this poster we summarize the very first results on pPNe and PNe obtained with Herschel/HiFi. In particular we note the detection of intense emission from the bipolar fast flows in the C-rich pPNe CRL 618. A crude comparison with the existing models for the source, indicates that this emission comes from the base of the very fast shock-accelerated jets. Results on additional sources, like NGC 6302, the Red Rectangle, and others, are also discussed.

  8. Mean Blood Pressure Assessment during Post-Exercise: Result from Two Different Methods of Calculation

    PubMed Central

    Sainas, Gianmarco; Milia, Raffaele; Palazzolo, Girolamo; Ibba, Gianfranco; Marongiu, Elisabetta; Roberto, Silvana; Pinna, Virginia; Ghiani, Giovanna; Tocco, Filippo; Crisafulli, Antonio

    2016-01-01

    At rest the proportion between systolic and diastolic periods of the cardiac cycle is about 1/3 and 2/3 respectively. Therefore, mean blood pressure (MBP) is usually calculated with a standard formula (SF) as follows: MBP = diastolic blood pressure (DBP) + 1/3 [systolic blood pressure (SBP) – DBP]. However, during exercise this proportion is lost because of tachycardia, which shortens diastole more than systole. We analysed the difference in MBP calculation between the SF and a corrected formula (CF) which takes into account changes in the diastolic and systolic periods caused by exercise-induced tachycardia. Our hypothesis was that the SF potentially induce a systematic error in MBP assessment during recovery after exercise. Ten healthy males underwent two exercise-recovery tests on a cycle-ergometer at mild-moderate and moderate-heavy workloads. Hemodynamics and MBP were monitored for 30 minutes after exercise bouts. The main result was that the SF on average underestimated MBP by –4.1 mmHg with respect to the CF. Moreover, in the period immediately after exercise, when sustained tachycardia occurred, the difference between SF and CF was large (in the order of -20-30 mmHg). Likewise, a systematic error in systemic vascular resistance assessment was present. It was concluded that the SF introduces a substantial error in MBP estimation in the period immediately following effort. This equation should not be used in this situation. Key points The standard formula often employed to calculate mean blood pressure during recovery from exercise may introduce a substantial error in the estimation of this parameter; This equation should not be used in this situation; Instead a corrected formula, which calculates mean blood pressure taking into account the systolic and diastolic proportion during the cardiac cycle, should be employed. No significant hypotensive due to exercise effect was detected using this formula. PMID:27803621

  9. Researchers' experience with project management in health and medical research: Results from a post-project review

    PubMed Central

    2011-01-01

    Background Project management is widely used to deliver projects on time, within budget and of defined quality. However, there is little published information describing its use in managing health and medical research projects. We used project management in the Alcohol and Pregnancy Project (2006-2008) http://www.ichr.uwa.edu.au/alcoholandpregnancy and in this paper report researchers' opinions on project management and whether it made a difference to the project. Methods A national interdisciplinary group of 20 researchers, one of whom was the project manager, formed the Steering Committee for the project. We used project management to ensure project outputs and outcomes were achieved and all aspects of the project were planned, implemented, monitored and controlled. Sixteen of the researchers were asked to complete a self administered questionnaire for a post-project review. Results The project was delivered according to the project protocol within the allocated budget and time frame. Fifteen researchers (93.8%) completed a questionnaire. They reported that project management increased the effectiveness of the project, communication, teamwork, and application of the interdisciplinary group of researchers' expertise. They would recommend this type of project management for future projects. Conclusions Our post-project review showed that researchers comprehensively endorsed project management in the Alcohol and Pregnancy Project and agreed that project management had contributed substantially to the research. In future, we will project manage new projects and conduct post-project reviews. The results will be used to encourage continuous learning and continuous improvement of project management, and provide greater transparency and accountability of health and medical research. The use of project management can benefit both management and scientific outcomes of health and medical research projects. PMID:21635721

  10. The interplay of multiple feedback loops with post-translational kinetics results in bistability of mycobacterial stress response

    PubMed Central

    Tiwari, Abhinav; Balázsi, Gábor; Gennaro, Maria Laura; Igoshin, Oleg A

    2011-01-01

    Bacterial persistence is the phenomenon in which a genetically identical fraction of a bacterial population can survive exposure to stress by reduction or cessation of growth. Persistence in mycobacteria has been recently linked to a stress-response network, consisting of the MprA/MprB two-component system and alternative sigma factor σE. This network contains multiple positive transcriptional feedback loops which may give rise to bistability, making it a good candidate for controlling the mycobacterial persistence switch. To analyze the possibility of bistability, we develop a method that involves decoupling of the network into transcriptional and post-translational interaction modules. As a result we reduce the dimensionality of the dynamical system and independently analyze input–output relations in the two modules to formulate a necessary condition for bistability in terms of their logarithmic gains. We show that neither the positive autoregulation in the MprA/MprB network nor the σE-mediated transcriptional feedback is sufficient to induce bistability in a biochemically realistic parameter range. Nonetheless, inclusion of the post-translational regulation of σE by RseA increases the effective cooperativity of the system, resulting in bistability that is robust to parameter variation. We predict that overexpression or deletion of RseA, the key element controlling the ultrasensitive response, can eliminate bistability. PMID:20733247

  11. Post-cardiotomy ECMO in pediatric and congenital heart surgery: impact of team training and equipment in the results

    PubMed Central

    Miana, Leonardo Augusto; Canêo, Luiz Fernando; Tanamati, Carla; Penha, Juliano Gomes; Guimarães, Vanessa Alves; Miura, Nana; Galas, Filomena Regina Barbosa Gomes; Jatene, Marcelo Biscegli

    2015-01-01

    Introduction Post-cardiotomy myocardial dysfunction requiring mechanical circulatory support occurs in about 0.5% of cases. In our environment, the use of extracorporeal membrane oxygenation has been increasing in recent years. Objective To evaluate the impact of investment in professional training and improvement of equipment in the rate of weaning from extracorporeal membrane oxygenation and survival. Methods A retrospective study. Fifty-six pediatric and/or congenital heart patients underwent post-cardiotomy extracorporeal membrane oxygenation at our institution between November 1999 and July 2014. We divided this period into two phases: phase I, 36 cases (before the structuring of the extracorporeal membrane oxygenation program) and phase II, 20 cases (after the extracorporeal membrane oxygenation program implementation) with investment in training and equipment). Were considered as primary outcomes: extracorporeal membrane oxygenation weaning and survival to hospital discharge. The results in both phases were compared using Chi-square test. To identify the impact of the different variables we used binary logistic regression analysis. Results Groups were comparable. In phase I, 9 patients (25%) were weaned from extracorporeal membrane oxygenation, but only 2 (5.5%) were discharged. In phase II, extracorporeal membrane oxygenation was used in 20 patients, weaning was possible in 17 (85%), with 9 (45%) hospital discharges (P<0.01). When the impact of several variables on discharge and weaning of extracorporeal membrane oxygenation was analyzed, we observe that phase II was an independent predictor of better results (P<0.001) and need for left cavities drainage was associated with worse survival (P=0.045). Conclusion The investment in professional training and improvement of equipment significantly increased extracorporeal membrane oxygenation results. PMID:27163414

  12. Evaluation of the heat transfer module (FAHT) of Failure Analysis Nonlinear Thermal And Structural Integrated Code (FANTASTIC)

    NASA Technical Reports Server (NTRS)

    Keyhani, Majid

    1989-01-01

    The heat transfer module of FANTASTIC Code (FAHT) is studied and evaluated to the extend possible during the ten weeks duration of this project. A brief background of the previous studies is given and the governing equations as modeled in FAHT are discussed. FAHT's capabilities and limitations based on these equations and its coding methodology are explained in detail. It is established that with improper choice of element size and time step FAHT's temperature field prediction at some nodes will be below the initial condition. The source of this unrealistic temperature prediction is identified and a procedure is proposed for avoiding this phenomenon. It is further shown that the proposed procedure will converge to an accurate prediction upon mesh refinement. Unfortunately due to lack of time FAHT's ability to accurately account for pyrolysis and surface ablation has not been verified. Therefore, at the present time it can be stated with confidence that FAHT can accurately predict the temperature field for a transient multi-dimensional, orthotropic material with directional dependence, variable property, with nonlinear boundary condition. Such a prediction will provide an upper limit for the temperature field in an ablating decomposing nozzle liner. The pore pressure field, however, will not be known.

  13. Observational Results of Diurnal Variation in Quiet Time Inner Plasmasphere Equatorial Noise Leading to Post-Midnight Ion Loss

    NASA Astrophysics Data System (ADS)

    Sarno-Smith, L. K.; Liemohn, M. W.; Skoug, R. M.; Morley, S.; Breneman, A. W.; Larsen, B.; Reeves, G. D.; Wygant, J. R.; Kletzing, C.; Hospodarsky, G. B.; Moldwin, M.; Katus, R. M.; Zou, S.

    2015-12-01

    After the discovery of the plasmaspheric post-midnight 1-10 eV ion loss between L =2 and L =3, we have expanded upon these results and connected the observed ion loss with changes in plasma wave activity. Using the Van Allen Probes Helium, Oxygen, Proton, and Electron (HOPE) and the Electric and Magnetic Field Instrument Suite and Integrated Science (EMFISIS) instruments, we observed that diurnal variation in EMFISIS equatorial noise measurements was consistent with HOPE H+ thermal ion measurement variations. Through statistical studies and case studies, we present how enhanced dayside equatorial noise heats via cyclotron resonance to form the 1-10 eV ion population of the inner plasmasphere during quiet time.

  14. Deep Vadose Zone Treatability Test for the Hanford Central Plateau. Interim Post-Desiccation Monitoring Results, Fiscal Year 2015

    SciTech Connect

    Truex, Michael J.; Strickland, Christopher E.; Oostrom, Martinus; Johnson, Christian D.; Tartakovsky, Guzel D.; Johnson, Timothy C.; Clayton, Ray E.; Chronister, Glen B.

    2015-09-01

    A field test of desiccation is being conducted as an element of the Deep Vadose Zone Treatability Test Program. The active desiccation portion of the test has been completed. Monitoring data have been collected at the field test site during the post-desiccation period and are reported herein. This is an interim data summary report that includes about 4 years of post-desiccation monitoring data. The DOE field test plan proscribes a total of 5 years of post-desiccation monitoring.

  15. Febrile Infection in Post-Prostate Biopsy: Results of a Ten-Year Single-Institution Study in South Taiwan

    PubMed Central

    Tsai, Yuh-Shyan; Chen, Chia-Hong; Jou, Yeong-Chin; Yang, Wen-Horng; Chang, Chien-Chen

    2014-01-01

    Abstract Background: Post-biopsy infection is one of the major concerns of urologists and patients for prostate biopsy. Many efforts have been made to reduce the infection rate. We conducted a study at a single institution with the goal of describing the bacteriology and incidence trends of febrile infections following trans-rectal ultrasound (TRUS)-guided biopsy of the prostate. Materials and Methods: From January 1998 to December 2002 (Period 1 of the study), January 2003 to August 2005 (Period 2), September 2005 to October 2007 (Period 3), and November 2007 to December 2009 (Period 4), 1,406 patients underwent prostate biopsy at our hospital. All biopsies were conducted under TRUS guidance without preparation by enemas. Several steps were taken to reduce infectious complications following biopsy, including a shift to levofloxacin prophylaxis starting from Period 3 of our study and thorough instructions in post-biopsy self-care starting from the beginning of Period 4. The incidence and bacteriology of urinary tract infection (UTI) following the prostate biopsies were reviewed from chart records. Results: Twenty-eight of 514 (5.4%), 13 of 276 (4.7%) nine of 274 (3.2%), and three of 342 (0.9%) patients had post-biopsy febrile infections during the four periods of the study, respectively. Fifteen of 28 (53.5%), four of 13 (30.8%), five of nine (55.6%), and zero of three patients, respectively, had positive cultures of blood, urine, or both during the four study periods. Escherichia coli was the pathogen isolated most commonly and ampicillin- and fluoroquinolone-resistant strains of this organism were identified at a high frequency. The times to onset of fever after biopsy in the four study periods were 1.5±1.3 d, 3.7±2.7 d, 2.2±1.6 d, and 2.5±0.9 d, respectively. Conclusions: Ampicillin- and fluoroquinolone-resistant strains of E. coli were the uropathogenic bacteria identified most commonly after prostate biopsy at our hospital. The incidence of UTI

  16. Manipulation of DET1 expression in tomato results in photomorphogenic phenotypes caused by post-transcriptional gene silencing

    PubMed Central

    Davuluri, Ganga Rao; van Tuinen, Ageeth; Mustilli, Anna Chiara; Manfredonia, Alessandro; Newman, Robert; Burgess, Diane; Brummell, David A.; King, Stephen R.; Palys, Joe; Uhlig, John; Pennings, Henk M. J.; Bowler, Chris

    2013-01-01

    Summary The tomato HIGH PIGMENT-2 gene encodes an orthologue of the Arabidopsis nuclear protein DE-ETIOLATED 1 (DET1). From genetic analyses it has been proposed that DET1 is a negative regulator of light signal transduction, and recent results indicate that it may control light-regulated gene expression at the level of chromatin remodelling. To gain further understanding about the function of DET1 during plant development, we generated a range of overexpression constructs and introduced them into tomato. Unexpectedly, we only observed phenotypes characteristic of DET1 inactivation, i.e. hyper-responsiveness to light. Molecular analysis indicated in all cases that these phenotypes were a result of suppression of endogenous DET1 expression, due to post-transcriptional gene silencing. DET1 silencing was often lethal when it occurred at relatively early stages of plant development, whereas light hyper-responsive phenotypes were obtained when silencing occurred later on. The appearance of phenotypes correlated with the generation of siRNAs but not DNA hypermethylation, and was most efficient when using constructs with mutations in the DET1 coding sequence or with constructs containing only the 3′-terminal portion of the gene. These results indicate an important function for DET1 throughout plant development and demonstrate that silencing of DET1 in fruits results in increased carotenoids, which may have biotechnological potential. PMID:15469492

  17. Antiretroviral pharmacokinetics in mothers and breastfeeding infants from 6 to 24 weeks post partum: results of the BAN Study

    PubMed Central

    Corbett, Amanda H; Kayira, Dumbani; White, Nicole R; Davis, Nicole L; Kourtis, Athena P; Chasela, Charles; Martinson, Francis; Phiri, Grace; Musisi, Bonaface; Kamwendo, Deborah; Hudgens, Michael G; Hosseinipour, Mina C; Nelson, Julie AE; Ellington, Sascha R; Jamieson, Denise J; van der Horst, Charles; Kashuba, Angela

    2014-01-01

    Background An intensive, prospective, open-label pharmacokinetic (PK) study in a subset of HIV-infected mothers and their uninfected infants enrolled in the Breastfeeding, Antiretroviral, and Nutrition study was performed to describe drug exposure and antiviral response. Methods Women using Combivir®[zidovudine (ZDV)+ lamivudine (3TC)]+Aluvia®[lopinavir/ritonavir(LPV/RTV)] were enrolled. Breast milk (BM) and mother and infant plasma (MP, IP) samples were obtained over 6hrs after observed dosing at 6, 12, or 24wks post-partum for drug concentrations and HIV RNA. Results 30 mother/infant pairs (10 each at 6, 12,and 24wks post-partum) were enrolled. Relative to MP, BM concentrations of ZDV and 3TC were 35% and 21% higher, while LPV and RTV were 80% lower. Only 3TC was detected in IP with concentrations 96% and 98% lower than MP and BM, respectively. Concentrations in all matrices were similar at 6-24wks. The majority (98.3%) of BM concentrations were >HIVwt IC50, with one having detectable virus. There was no association between PK parameters and MP or BM HIV RNA. Conclusions ZDV and 3TC concentrated in BM while LPV and RTV did not, possibly due to protein binding and drug transporter affinity. Undetectable to low ARV concentrations in IP suggests prevention of transmission while breast feeding may be due to ARV effects on systemic or BM HIV RNA in the mother. Low IP 3TC exposure may predispose an infected infant to HIV resistance, necessitating testing and treating infants early. PMID:24464632

  18. Nox2-derived oxidative stress results in inefficacy of antibiotics against post-influenza S. aureus pneumonia.

    PubMed

    Sun, Keer; Yajjala, Vijaya Kumar; Bauer, Christopher; Talmon, Geoffrey A; Fischer, Karl J; Kielian, Tammy; Metzger, Dennis W

    2016-08-22

    Clinical post-influenza Staphylococcus aureus pneumonia is characterized by extensive lung inflammation associated with severe morbidity and mortality even after appropriate antibiotic treatment. In this study, we show that antibiotics rescue nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (Nox2)-deficient mice but fail to fully protect WT animals from influenza and S. aureus coinfection. Further experiments indicate that the inefficacy of antibiotics against coinfection is attributable to oxidative stress-associated inflammatory lung injury. However, Nox2-induced lung damage during coinfection was not associated with aggravated inflammatory cytokine response or cell infiltration but rather caused by reduced survival of myeloid cells. Specifically, oxidative stress increased necrotic death of inflammatory cells, thereby resulting in lethal damage to surrounding tissue. Collectively, our results demonstrate that influenza infection disrupts the delicate balance between Nox2-dependent antibacterial immunity and inflammation. This disruption leads to not only increased susceptibility to S. aureus infection, but also extensive lung damage. Importantly, we show that combination treatment of antibiotic and NADPH oxidase inhibitor significantly improved animal survival from coinfection. These findings suggest that treatment strategies that target both bacteria and oxidative stress will significantly benefit patients with influenza-complicated S. aureus pneumonia. PMID:27526712

  19. Post-Flight Test Results of Seed Laser Module Subjected to Space Exposure. Paper No. 8876-9

    NASA Technical Reports Server (NTRS)

    Prasad, Narasimha S.

    2013-01-01

    The objective of the Materials International Space Station Experiment (MISSE) is to study the performance of novel materials when subjected to the synergistic effects of the harsh space environment for several months. MISSE missions provide an opportunity for developing space qualifiable materials. Several laser and lidar components were sent by NASA Langley Research Center (LaRC) as a part of the MISSE 7 mission. The MISSE 7 module was transported to the international space station (ISS) via STS 129 mission that was launched on Nov 16, 2009. Later, the MISSE 7 module was brought back to the earth via the STS 134 that landed on June 1, 2011. The MISSE 7 module that was subjected to exposure in space environment for more than one and a half year included fiber laser, solid-state laser gain materials, detectors, and semiconductor laser diode. Performance testing of these components is now progressing. In this paper, the results of performance testing of a laser diode module sent by NASA Langley Research Center on MISSE 7 mission will be discussed. This paper will present the comparison of pre-flight and post-flight performance curves and discuss the effect of space exposure on the laser diode module. Preliminary findings on output power measurements show that the COTS laser diode characteristics did not undergo any significant performance degradation.

  20. Association between traumatic events and post-traumatic stress disorder: results from the ESEMeD-Spain study

    PubMed Central

    Olaya, B.; Alonso, J.; Atwoli, L.; Kessler, R. C.; Vilagut, G.; Haro, J. M.

    2014-01-01

    Background The relative importance of traumatic events (TEs) in accounting for the social burden of post-traumatic stress disorder (PTSD) could vary according to cross-cultural factors. In that sense, no such studies have yet been conducted in the Spanish general population. The present study aims to determine the epidemiology of trauma and PTSD in a Spanish community sample using the randomly selected TEs method. Methods The European Study of the Epidemiology of Mental Disorders (ESEMeD)-Spain is a cross-sectional household survey of a representative sample of adult population. Lifetime prevalence of self-reported TEs and lifetime and 12-month prevalence of PTSD were evaluated using the World Health Organization (WHO) Composite International Diagnostic Interview. Reports of PTSD associated with randomly selected TEs were weighted by the individual-level probabilities of TE selection to generate estimates of population-level PTSD risk associated with each TE. Results Road accident was the most commonly self-reported TE (14.1%). Sexual assault had the highest conditional risk of PTSD (16.5%). The TEs that contributed most to societal PTSD burden were unexpected death of a loved one (36.4% of all cases) and sexual assault (17.2%). Being female and having a low educational level were associated with low risk of overall TE exposure and being previously married was related to higher risk. Being female was related to high risk of PTSD after experiencing a TE. Conclusions Having an accident is commonly reported among Spanish adults, but two TE are responsible for the highest burden associated with PTSD: the unexpected death of someone close and sexual assault. These results can help designing public health interventions to reduce the societal PTSD burden. PMID:24565167

  1. Fantastic plastic? Experimental evaluation of polyurethane bone substitutes as proxies for human bone in trauma simulations.

    PubMed

    Smith, Martin J; James, Stephen; Pover, Tim; Ball, Nina; Barnetson, Victoria; Foster, Bethany; Guy, Carl; Rickman, John; Walton, Virginia

    2015-09-01

    Recent years have seen steady improvements in the recognition and interpretation of violence related injuries in human skeletal remains. Such work has at times benefited from the involvement of biological anthropologists in forensic casework and has often relied upon comparison of documented examples with trauma observed in skeletal remains. In cases where no such example exists investigators must turn to experimentation. The selection of experimental samples is problematic as animal proxies may be too dissimilar to humans and human cadavers may be undesirable for a raft of reasons. The current article examines a third alternative in the form of polyurethane plates and spheres marketed as viable proxies for human bone in ballistic experiments. Through subjecting these samples to a range of impacts from both modern and archaic missile weapons it was established that such material generally responds similarly to bone on a broad, macroscopic scale but when examined in closer detail exhibits a range of dissimilarities that call for caution in extrapolating such results to real bone. PMID:26130519

  2. Fantastic plastic? Experimental evaluation of polyurethane bone substitutes as proxies for human bone in trauma simulations.

    PubMed

    Smith, Martin J; James, Stephen; Pover, Tim; Ball, Nina; Barnetson, Victoria; Foster, Bethany; Guy, Carl; Rickman, John; Walton, Virginia

    2015-09-01

    Recent years have seen steady improvements in the recognition and interpretation of violence related injuries in human skeletal remains. Such work has at times benefited from the involvement of biological anthropologists in forensic casework and has often relied upon comparison of documented examples with trauma observed in skeletal remains. In cases where no such example exists investigators must turn to experimentation. The selection of experimental samples is problematic as animal proxies may be too dissimilar to humans and human cadavers may be undesirable for a raft of reasons. The current article examines a third alternative in the form of polyurethane plates and spheres marketed as viable proxies for human bone in ballistic experiments. Through subjecting these samples to a range of impacts from both modern and archaic missile weapons it was established that such material generally responds similarly to bone on a broad, macroscopic scale but when examined in closer detail exhibits a range of dissimilarities that call for caution in extrapolating such results to real bone.

  3. The safety of quetiapine: results of a post-marketing surveillance study on 1728 patients in England.

    PubMed

    Twaites, Beverley R; Wilton, Lynda V; Shakir, Saad A W

    2007-06-01

    The safety of the atypical antipsychotic quetiapine as used in general practice in England was examined by prescription-event monitoring (PEM). Patients were identified from dispensed National Health Service (NHS) prescriptions issued by general practitioners (GPs) for quetiapine between October 1997 and July 1999. The outcome data were event reports obtained by sending questionnaires ('green forms') to the prescribing doctor at Least 6 months after the first prescription for an individual patient. Green forms with clinically useful information on 1728 patients (median age 39 years (IQR 30-56); 53% female) were received. The most frequently reported event during the first month of treatment was 'drowsiness/sedation' (47; 3% cohort). This was also the most frequently reported specified adverse drug reaction (ADR) to quetiapine (7; 11% of 65 reported ADRs) and the highest reported clinical reason for stopping quetiapine (51; 6% of the 734 reported reasons for stopping). There was a low incidence of extrapyramidal disease (21 during treatment, 1% of cohort) and hyperprolactinaemia (three during treatment, 0.2%) in this study. Three cases of diabetes mellitus in this cohort were reported to be a new diagnosis. Six pregnancies were reported during treatment with quetiapine, five of which were exposed during the first trimester only. There were four Live births with no reported congenital abnormaLities. Fifty-six deaths were reported during this study (3% cohort). The most frequently reported causes of death reLated to the cardiovascular (18) and respiratory (15) systems. The results of this post-marketing surveillance study demonstrated that quetiapine is generally well-tolerated when used in general practice. PMID:17656426

  4. Increasing Interest in Child and Adolescent Psychiatry in the Third-Year Clerkship: Results from a Post-Clerkship Survey

    ERIC Educational Resources Information Center

    Malloy, Erin; Hollar, David; Lindsey, Anthony

    2008-01-01

    Objective: The authors aimed to determine whether a structured clinical experience in child and adolescent psychiatry (CAP) during the third-year psychiatry clerkship would impact interest in pursuing careers in psychiatry and CAP. Methods: The authors constructed and administered a post-rotation survey, the Child and Adolescent Psychiatry…

  5. 2008 Admissions and Transfer Experiences of Students Continuing Their Post-Secondary Studies in British Columbia. Research Results

    ERIC Educational Resources Information Center

    British Columbia Council on Admissions and Transfer, 2009

    2009-01-01

    The British Columbia (BC) post-secondary system is a geographically dispersed network of colleges, institutes, university colleges, and universities. The success of such a diverse system depends on students' ability to move easily through the system, accessing the institutions, programs of study, and courses that they need and, where appropriate,…

  6. What Students Said about Interactive Video Instruction: Results of Two Surveys Conducted by the West Suburban Post-Secondary Consortium.

    ERIC Educational Resources Information Center

    Lester, Marilyn A.

    The West Suburban Post-Secondary Consortium (WSPSC) of Oak Brook, Illinois is a not-for-profit organization of collaborating educational institutions that offer courses, programs and degrees in the western suburbs of Chicago. Interactive video is a successful instructional delivery method in the WSPSC, according to the students who took video…

  7. EleFantastic Bingo.

    ERIC Educational Resources Information Center

    Rule, Audrey C.

    This game allows students to learn new science vocabulary and relevant facts about elephants. This bingo game is a valuable curriculum resource for any teacher who is teaching about elephants or other endangered animals. Directions for play, calling cards (six to a page), and play cards (four to a page), are included. (ASK)

  8. Creating Fantastic PI Workshops

    SciTech Connect

    Biedermann, Laura B.; Clark, Blythe G.; Colbert, Rachel S.; Dagel, Amber Lynn; Gupta, Vipin P.; Hibbs, Michael R.; Perkins, David Nikolaus; West, Roger Derek

    2015-10-01

    The goal of this SAND report is to provide guidance for other groups hosting workshops and peerto-peer learning events at Sandia. Thus this SAND report provides detail about our team structure, how we brainstormed workshop topics and developed the workshop structure. A Workshop “Nuts and Bolts” section provides our timeline and check-list for workshop activities. The survey section provides examples of the questions we asked and how we adapted the workshop in response to the feedback.

  9. The City Fantastic

    ERIC Educational Resources Information Center

    Donahue, Nannette Wargo

    2008-01-01

    Since ancient times, the supernatural has captivated storytellers and their audiences. Some of the earliest surviving literary forms--myths and folktales--feature such preternatural beings as gods, ghosts, fairies, witches, or vampires living among humans. Today, this fascination exists in the current boom in urban fantasy, a genre defined by John…

  10. Probability of a false-negative HIV antibody test result during the window period: a tool for pre- and post-test counselling.

    PubMed

    Taylor, Darlene; Durigon, Monica; Davis, Heather; Archibald, Chris; Konrad, Bernhard; Coombs, Daniel; Gilbert, Mark; Cook, Darrel; Krajden, Mel; Wong, Tom; Ogilvie, Gina

    2015-03-01

    Failure to understand the risk of false-negative HIV test results during the window period results in anxiety. Patients typically want accurate test results as soon as possible while clinicians prefer to wait until the probability of a false-negative is virtually nil. This review summarizes the median window periods for third-generation antibody and fourth-generation HIV tests and provides the probability of a false-negative result for various days post-exposure. Data were extracted from published seroconversion panels. A 10-day eclipse period was used to estimate days from infection to first detection of HIV RNA. Median (interquartile range) days to seroconversion were calculated and probabilities of a false-negative result at various time periods post-exposure are reported. The median (interquartile range) window period for third-generation tests was 22 days (19-25) and 18 days (16-24) for fourth-generation tests. The probability of a false-negative result is 0.01 at 80 days' post-exposure for third-generation tests and at 42 days for fourth-generation tests. The table of probabilities of falsely-negative HIV test results may be useful during pre- and post-test HIV counselling to inform co-decision making regarding the ideal time to test for HIV.

  11. Deep Vadose Zone Treatability Test for the Hanford Central Plateau: Interim Post-Desiccation Monitoring Results, Fiscal Year 2014

    SciTech Connect

    Truex, Michael J.; Strickland, Christopher E.; Johnson, Christian D.; Johnson, Timothy C.; Clayton, Ray E.; Chronister, Glen B.

    2014-09-01

    Over decades of operation, the U.S. Department of Energy (DOE) and its predecessors have released nearly 2 trillion L (450 billion gal.) of liquid into the vadose zone at the Hanford Site. Much of this discharge of liquid waste into the vadose zone occurred in the Central Plateau, a 200 km2 (75 mi2) area that includes approximately 800 waste sites. Some of the inorganic and radionuclide contaminants in the deep vadose zone at the Hanford Site are at depths below the limit of direct exposure pathways, but may need to be remediated to protect groundwater. The Tri-Party Agencies (DOE, U.S. Environmental Protection Agency, and Washington State Department of Ecology) established Milestone M 015 50, which directed DOE to submit a treatability test plan for remediation of technetium-99 (Tc-99) and uranium in the deep vadose zone. These contaminants are mobile in the subsurface environment and have been detected at high concentrations deep in the vadose zone, and at some locations have reached groundwater. Testing technologies for remediating Tc-99 and uranium will also provide information relevant for remediating other contaminants in the vadose zone. A field test of desiccation is being conducted as an element of the DOE test plan published in March 2008 to meet Milestone M 015 50. The active desiccation portion of the test has been completed. Monitoring data have been collected at the field test site during the post-desiccation period and are reported herein. This is an interim data summary report that includes about 3 years of post-desiccation monitoring data. The DOE field test plan proscribes a total of 5 years of post-desiccation monitoring.

  12. 99mTc-DTPA aerosol for same-day post-perfusion ventilation imaging: results of a multicentre study.

    PubMed

    Köhn, H; Mostbeck, A; Bachmayr, S; Eber, O; Galvan, G; Holm, C; König, B; Lind, P; Markt, B; Ogris, E

    1993-01-01

    A multicentre study was performed in an attempt to evaluate a submicronic technetium-99m diethylene triamine penta-acetic acid aerosol generated by a newly developed delivery system, the aerosol production equipment (APE nebulizer), for same-day post-perfusion ventilation imaging in patients with clinically suspected pulmonary embolism. Quantitative comparison between the DTPA aerosol and krypton gas demonstrated a close correlation with respect to regional pulmonary distribution of activity and peripheral lung penetration (n = 14, r = 0.94, P < 0.001 and r = 0.75, P < 0.0025, respectively). In 169 consecutive patients, DTPA aerosol images performed immediately following perfusion (inhalation scan I) were compared to those carried out on the next day (inhalation scan II) with respect to image quality and assessment of perfusion-ventilation matches or mismatches. Agreement between inhalation scans I and II with respect to perfusion defects matched or mismatched to ventilation was found in 166/169 (98%) studies. The image quality of inhalation scan I was equal to that of scan II in 72%; inhalation scan I was superior in 11% of cases, while scan II was superior in 17%. This submicronic 99mTc-labelled DTPA aerosol is well suited for fast same-day post-perfusion ventilation imaging in patients with clinical suspicion of pulmonary embolism.

  13. Variations in the Post-weaning Human Gut Metagenome Profile As Result of Bifidobacterium Acquisition in the Western Microbiome.

    PubMed

    Soverini, Matteo; Rampelli, Simone; Turroni, Silvia; Schnorr, Stephanie L; Quercia, Sara; Castagnetti, Andrea; Biagi, Elena; Brigidi, Patrizia; Candela, Marco

    2016-01-01

    Studies of the gut microbiome variation among human populations revealed the existence of robust compositional and functional layouts matching the three subsistence strategies that describe a trajectory of changes across our recent evolutionary history: hunting and gathering, rural agriculture, and urban post-industrialized agriculture. In particular, beside the overall reduction of ecosystem diversity, the gut microbiome of Western industrial populations is typically characterized by the loss of Treponema and the acquisition of Bifidobacterium as an abundant inhabitant of the post-weaning gut microbial ecosystem. In order to advance the hypothesis about the possible adaptive nature of this exchange, here we explore specific functional attributes that correspond to the mutually exclusive presence of Treponema and Bifidobacterium using publically available gut metagenomic data from Hadza hunter-gatherers and urban industrial Italians. According to our findings, Bifidobacterium provides the enteric ecosystem with a diverse panel of saccharolytic functions, well suited to the array of gluco- and galacto-based saccharides that abound in the Western diet. On the other hand, the metagenomic functions assigned to Treponema are more predictive of a capacity to incorporate complex polysaccharides, such as those found in unrefined plant foods, which are consistently incorporated in the Hadza diet. Finally, unlike Treponema, the Bifidobacterium metagenome functions include genes that permit the establishment of microbe-host immunological cross-talk, suggesting recent co-evolutionary events between the human immune system and Bifidobacterium that are adaptive in the context of agricultural subsistence and sedentary societies.

  14. Variations in the Post-weaning Human Gut Metagenome Profile As Result of Bifidobacterium Acquisition in the Western Microbiome

    PubMed Central

    Soverini, Matteo; Rampelli, Simone; Turroni, Silvia; Schnorr, Stephanie L.; Quercia, Sara; Castagnetti, Andrea; Biagi, Elena; Brigidi, Patrizia; Candela, Marco

    2016-01-01

    Studies of the gut microbiome variation among human populations revealed the existence of robust compositional and functional layouts matching the three subsistence strategies that describe a trajectory of changes across our recent evolutionary history: hunting and gathering, rural agriculture, and urban post-industrialized agriculture. In particular, beside the overall reduction of ecosystem diversity, the gut microbiome of Western industrial populations is typically characterized by the loss of Treponema and the acquisition of Bifidobacterium as an abundant inhabitant of the post-weaning gut microbial ecosystem. In order to advance the hypothesis about the possible adaptive nature of this exchange, here we explore specific functional attributes that correspond to the mutually exclusive presence of Treponema and Bifidobacterium using publically available gut metagenomic data from Hadza hunter-gatherers and urban industrial Italians. According to our findings, Bifidobacterium provides the enteric ecosystem with a diverse panel of saccharolytic functions, well suited to the array of gluco- and galacto-based saccharides that abound in the Western diet. On the other hand, the metagenomic functions assigned to Treponema are more predictive of a capacity to incorporate complex polysaccharides, such as those found in unrefined plant foods, which are consistently incorporated in the Hadza diet. Finally, unlike Treponema, the Bifidobacterium metagenome functions include genes that permit the establishment of microbe–host immunological cross-talk, suggesting recent co-evolutionary events between the human immune system and Bifidobacterium that are adaptive in the context of agricultural subsistence and sedentary societies. PMID:27462302

  15. Variations in the Post-weaning Human Gut Metagenome Profile As Result of Bifidobacterium Acquisition in the Western Microbiome.

    PubMed

    Soverini, Matteo; Rampelli, Simone; Turroni, Silvia; Schnorr, Stephanie L; Quercia, Sara; Castagnetti, Andrea; Biagi, Elena; Brigidi, Patrizia; Candela, Marco

    2016-01-01

    Studies of the gut microbiome variation among human populations revealed the existence of robust compositional and functional layouts matching the three subsistence strategies that describe a trajectory of changes across our recent evolutionary history: hunting and gathering, rural agriculture, and urban post-industrialized agriculture. In particular, beside the overall reduction of ecosystem diversity, the gut microbiome of Western industrial populations is typically characterized by the loss of Treponema and the acquisition of Bifidobacterium as an abundant inhabitant of the post-weaning gut microbial ecosystem. In order to advance the hypothesis about the possible adaptive nature of this exchange, here we explore specific functional attributes that correspond to the mutually exclusive presence of Treponema and Bifidobacterium using publically available gut metagenomic data from Hadza hunter-gatherers and urban industrial Italians. According to our findings, Bifidobacterium provides the enteric ecosystem with a diverse panel of saccharolytic functions, well suited to the array of gluco- and galacto-based saccharides that abound in the Western diet. On the other hand, the metagenomic functions assigned to Treponema are more predictive of a capacity to incorporate complex polysaccharides, such as those found in unrefined plant foods, which are consistently incorporated in the Hadza diet. Finally, unlike Treponema, the Bifidobacterium metagenome functions include genes that permit the establishment of microbe-host immunological cross-talk, suggesting recent co-evolutionary events between the human immune system and Bifidobacterium that are adaptive in the context of agricultural subsistence and sedentary societies. PMID:27462302

  16. Post-discharge compliance to venous thromboembolism prophylaxis in high-risk orthopaedic surgery: results from the ETHOS registry.

    PubMed

    Bergqvist, David; Arcelus, Juan I; Felicissimo, Paulo

    2012-02-01

    Venous thromboembolism (VTE) risk persists for several weeks following high-risk orthopaedic surgery (HROS). The ETHOS registry evaluated post-operative VTE prophylaxis prescribed, and actual VTE prophylaxis received, compared with the 2004 American College of Chest Physicians (ACCP) guidelines in HROS patients. We performed a subanalysis of ETHOS to assess patient compliance with ACCP-adherent prophylaxis after discharge and the factors predicting poor compliance. Consecutive patients undergoing hip fracture surgery, total hip arthroplasty, or knee arthroplasty were enrolled at discharge from 161 centres in 17 European countries if they had received adequate in-hospital VTE prophylaxis. Data on prescribed and actual prophylaxis received were obtained from hospital charts and patient post-discharge diaries. Good compliance was defined as percentage treatment intake ≥80% with no more than two consecutive days without treatment. A total of 3,484 patients (79.4%) received ACCP-adherent anticoagulant prescription at discharge and 2,999 (86.0%) had an evaluable patient diary. In total, 87.7% of evaluable patients were compliant with prescribed treatment after discharge. The most common reason for non-compliance (33.4%) was "drug was not bought". Injection of treatment was not a barrier to good compliance. Main factors affecting compliance related to purchase of and access to treatment, patient education, the person responsible for administering injections, country, and type of hospital ward at discharge. Within our study population, patient compliance with ACCP-adherent thromboprophylaxis prescribed at discharge was good. Improvements in patient education and prescribing practices at discharge may be important in further raising compliance levels in high-risk orthopaedic surgery patients.

  17. Post-bariatric abdominoplasty resulting in wound infection and dehiscence—Conservative treatment with medical grade honey: A case report and review of literature

    PubMed Central

    Dina Jarjis, Reem; Thomas Crewe, Bjørn; Henrik Matzen, Steen

    2016-01-01

    Introduction Wound complications in post-bariatric patients undergoing body-contouring surgery after massive weight loss are not uncommon and often, surgical debridement or conservative management is necessary. Honey is one of the most ancient remedies for wound care and it is also considered to possess debriding effects. Current research has demonstrated promising results showing that honey can improve wound granulation and epithelialization, reduce exudate and shorten healing times. Methods This case report has been reported in line with the CARE criteria. Presentation of case A 40 year-old female suffered wound infection and dehiscence after undergoing post-bariatric abdominoplasty. The patient was not interested in surgical revision and split skin grafting. Therefore, conservative wound treatment with topical Manuka honey was instituted resulting in significant clinical improvement and effective healing concurrently with good patient satisfaction. Discussion Surgical wound complications in post-bariatric patients undergoing abdominoplasty are common and often require surgical revision or conservative wound treatment. No previous publication has addressed outpatient treatment of post-bariatric abdominoplasty wound complications with medical grade honey. Conclusion Although more research is needed for definitive conclusions of honey’s efficacy, it is safe and as presented in our case, it may under certain circumstances reduce the need of surgical wound debridement and serve as a remedy for conservative treatment. PMID:26773204

  18. A mental health needs assessment of children and adolescents in post-conflict Liberia: results from a quantitative key-informant survey

    PubMed Central

    Borba, Christina P.C.; Ng, Lauren C.; Stevenson, Anne; Vesga-Lopez, Oriana; Harris, Benjamin L.; Parnarouskis, Lindsey; Gray, Deborah A.; Carney, Julia R.; Domínguez, Silvia; Wang, Edward K.S.; Boxill, Ryan; Song, Suzan J.; Henderson, David C.

    2016-01-01

    Between 1989 and 2004, Liberia experienced a devastating civil war that resulted in widespread trauma with almost no mental health infrastructure to help citizens cope. In 2009, the Liberian Ministry of Health and Social Welfare collaborated with researchers from Massachusetts General Hospital to conduct a rapid needs assessment survey in Liberia with local key informants (n = 171) to examine the impact of war and post-war events on emotional and behavioral problems of, functional limitations of, and appropriate treatment settings for Liberian youth aged 5–22. War exposure and post-conflict sexual violence, poverty, infectious disease and parental death negatively impacted youth mental health. Key informants perceived that youth displayed internalizing and externalizing symptoms and mental health-related functional impairment at home, school, work and in relationships. Medical clinics were identified as the most appropriate setting for mental health services. Youth in Liberia continue to endure the harsh social, economic and material conditions of everyday life in a protracted post-conflict state, and have significant mental health needs. Their observed functional impairment due to mental health issues further limited their access to protective factors such as education, employment and positive social relationships. Results from this study informed Liberia's first post-conflict mental health policy. PMID:26807147

  19. Importance of Local Control in Early-Stage Prostate Cancer: Outcomes of Patients With Positive Post-Radiation Therapy Biopsy Results Treated in RTOG 9408

    SciTech Connect

    Krauss, Daniel J.; Hu, Chen; Bahary, Jean-Paul; Souhami, Luis; Gore, Elizabeth M.; Chafe, Susan Maria Jacinta; Leibenhaut, Mark H.; Narayan, Samir; Torres-Roca, Javier; Michalski, Jeff; Zeitzer, Kenneth L.; Donavanik, Viroon; Sandler, Howard; McGowan, David G.; Jones, Christopher U.; Shipley, William U.

    2015-07-15

    Purpose: The purpose of this study was to assess the association between positive post-radiation therapy (RT) biopsy results and subsequent clinical outcomes in males with localized prostate cancer. Methods and Materials: Radiation Therapy Oncology Group study 94-08 analyzed 1979 males with prostate cancer, stage T1b-T2b and prostate-specific antigen concentrations of ≤20 ng/dL, to investigate whether 4 months of total androgen suppression (TAS) added to RT improved survival compared to RT alone. Patients randomized to receive TAS received flutamide with luteinizing hormone releasing hormone (LHRH) agonist. According to protocol, patients without evidence of clinical recurrence or initiation of additional endocrine therapy underwent repeat prostate biopsy 2 years after RT completion. Statistical analysis was performed to evaluate the impact of positive post-RT biopsy results on clinical outcomes. Results: A total of 831 patients underwent post-RT biopsy, 398 were treated with RT alone and 433 with RT plus TAS. Patients with positive post-RT biopsy results had higher rates of biochemical failure (hazard ratio [HR] = 1.7; 95% confidence interval [CI] = 1.3-2.1) and distant metastasis (HR = 2.4; 95% CI = 1.3-4.4) and inferior disease-specific survival (HR = 3.8; 95% CI = 1.9-7.5). Positive biopsy results remained predictive of such outcomes after correction for potential confounders such as Gleason score, tumor stage, and TAS administration. Prior TAS therapy did not prevent elevated risk of adverse outcome in the setting of post-RT positive biopsy results. Patients with Gleason score ≥7 with a positive biopsy result additionally had inferior overall survival compared to those with a negative biopsy result (HR = 1.56; 95% CI = 1.04-2.35). Conclusions: Positive post-RT biopsy is associated with increased rates of distant metastases and inferior disease-specific survival in patients treated with definitive RT and was associated with inferior overall

  20. LDEF SP-HVDE (Space Plasma-High Voltage Drainage Experiment) post-flight results: Leakage current and discharge

    NASA Technical Reports Server (NTRS)

    Yaung, J. Y.; Wong, W. C.; Blakkolb, B. K.; Ryan, L. E.; Chedotte, J. E.; Taylor, W. W. L.

    1992-01-01

    TRW designed and fabricated two identical SP-HVDE trays which were flown in the NASA LDEF (Long Duration Exposure Facility) for 5.75 years in the LEO (low earth orbit) environment. One tray was placed near the leading edge and one near the trailing edge, and investigations were performed to compare the environmental interactions on the dielectric samples of the two trays. Each tray consisted of six assemblies with Kapton dielectric samples of varying thicknesses (i.e., 2 mils, 3 mil, and 5 mils) biased under +/- 300 V, +/- 500 V, and +/- 1000 V. The original objective was successfully achieved by measuring the first in-flight average leakage current through the samples. Less than 5 percent of the post-flight coulometers behaved anomalously. The data should be valuable to the design and evaluation of spacecraft with high voltage systems. M/D (micrometeoroid and debris) impacts over the dielectric samples were examined using a SEM (Scanning Electron Microscope) and an EDS (Energy Dispersive x-ray Spectrometer). These impact sites were sprayed by silver which were most likely caused either by the impact or a 'local ESD' (electrostatic discharge).

  1. Endogenous post-transcriptional gene silencing of flavone synthase resulting in high accumulation of anthocyanins in black dahlia cultivars.

    PubMed

    Deguchi, Ayumi; Ohno, Sho; Hosokawa, Munetaka; Tatsuzawa, Fumi; Doi, Motoaki

    2013-05-01

    Black color in flowers is a highly attractive trait in the floricultural industry, but its underlying mechanisms are largely unknown. This study was performed to identify the bases of the high accumulation of anthocyanidins in black cultivars and to determine whether the high accumulation of total anthocyanidins alone leads to the black appearance. Our approach was to compare black dahlia (Dahlia variabilis) cultivars with purple cultivars and a purple flowering mutant of a black cultivar, using pigment and molecular analyses. Black cultivars characteristically exhibited low lightness, high petal accumulation of cyanidin and total anthocyanidins without flavones, and marked suppression of flavone synthase (DvFNS) expression. A comparative study using black and purple cultivars revealed that neither the absence of flavones nor high accumulation of total anthocyanidins is solely sufficient for black appearance, but that cyanidin content in petals is also an important factor in the phenotype. A study comparing the black cultivar 'Kokucho' and its purple mutant showed that suppression of DvFNS abolishes the competition between anthocyanidin and flavone synthesis and leads to accumulation of cyanidin and total anthocyanidins that produce a black appearance. Surprisingly, in black cultivars the suppression of DvFNS occurred in a post-transcriptional manner, as determined by small RNA mapping. PMID:23389674

  2. Results of the Ticlid or Plavix Post-Stents (TOPPS) trial: do they justify the switch from ticlopidine to clopidogrel after coronary stent placement?

    PubMed

    Berger, Peter B

    2000-01-01

    In the Ticlid or Plavix Post-Stents (TOPPS) trial, 1016 patients undergoing successful coronary stent placement were randomized to receive aspirin and either ticlopidine or clopidogrel. In this trial, the dosages and regimens of ticlopidine and clopidogrel resembled more closely those used in most catheterization laboratories than did the two previous randomized trials comparing ticlopidine and clopidogrel. The results of the TOPPS trial support the current practice of substituting ticlopidine for clopidogrel in stent patients.

  3. Results.

    ERIC Educational Resources Information Center

    Zemsky, Robert; Shaman, Susan; Shapiro, Daniel B.

    2001-01-01

    Describes the Collegiate Results Instrument (CRI), which measures a range of collegiate outcomes for alumni 6 years after graduation. The CRI was designed to target alumni from institutions across market segments and assess their values, abilities, work skills, occupations, and pursuit of lifelong learning. (EV)

  4. Steady Stream of High School Graduates Enter B.C. Public Post-Secondary Education for the First Time Each Year. Research Results from the Student Transitions Project

    ERIC Educational Resources Information Center

    Student Transitions Project, 2014

    2014-01-01

    The Student Transition project (STP) has collected eleven years of grade 12 and post-secondary enrollment data, since it's inception in 2003. This information is used to track student transitions from grade 12 graduation into post-secondary education, student mobility between post-secondary institutions and post-secondary credential completions.…

  5. Randomized clinical comparison of endodontically treated teeth restored with amalgam or with fiber posts and resin composite: five-year results.

    PubMed

    Mannocci, Francesco; Qualtrough, Alison J E; Worthington, Helen V; Watson, Timothy F; Pitt Ford, Thomas R

    2005-01-01

    Prospective clinical studies comparing the results of different types of restorations of endodontically treated teeth are lacking. This study compared the clinical success rate of endodontically treated premolars restored with fiber posts and direct composite to the restorations of premolars using amalgam. Premolars with Class II carious lesions were selected and randomly assigned to one of two experimental groups: (1) restoration with amalgam or (2) restoration with fiber posts and composite. One hundred and nine teeth were included in Group 1 and 110 in Group 2. Patients were recalled after 1, 3 and 5 years. No statistically significant difference was found between the proportion of failed teeth in the two experimental groups. Significant differences were observed between the proportion of root fractures (p=0.029) and caries (p=0.047), with more root fractures and less caries observed in the teeth restored with amalgam at the five-year recall. Within the limits of this study, it can be concluded that restorations with fiber posts and composite were found to be more effective than amalgam in preventing root fractures but less effective in preventing secondary caries. PMID:15765952

  6. Confirming and improving post-Newtonian and effective-one-body results from self-force computations along eccentric orbits around a Schwarzschild black hole

    NASA Astrophysics Data System (ADS)

    Bini, Donato; Damour, Thibault; Geralico, Andrea

    2016-03-01

    We analytically compute, through the six-and-a-half post-Newtonian order, the second-order-in-eccentricity piece of the Detweiler-Barack-Sago gauge-invariant redshift function for a small mass in eccentric orbit around a Schwarzschild black hole. Using the first law of mechanics for eccentric orbits [A. Le Tiec, First law of mechanics for compact binaries on eccentric orbits, Phys. Rev. D 92, 084021 (2015).] we transcribe our result into a correspondingly accurate knowledge of the second radial potential of the effective-one-body formalism [A. Buonanno and T. Damour, Effective one-body approach to general relativistic two-body dynamics, Phys. Rev. D 59, 084006 (1999).]. We compare our newly acquired analytical information to several different numerical self-force data and find good agreement, within estimated error bars. We also obtain, for the first time, independent analytical checks of the recently derived, comparable-mass fourth-post-Newtonian order dynamics [T. Damour, P. Jaranowski, and G. Schaefer, Nonlocal-in-time action for the fourth post-Newtonian conservative dynamics of two-body systems, Phys. Rev. D 89, 064058 (2014).].

  7. The use of risk sharing tools for post adoption surveillance of a non pharmacological technology in routine practice: results after one year

    PubMed Central

    2013-01-01

    Background To report results obtained by combining risk sharing tools with post-adoption surveillance mechanisms in order to control quality of care and implement a value-based reimbursement scheme for Neuro-reflexotherapy (NRT), a non-pharmacological treatment proven effective for neck pain (NP), thoracic pain (TP) and low back pain (LBP). Methods Pre-post prospective cohort study in routine clinical practice, carried out in primary care centers in the Spanish National Health Service in the Balearic Islands (Ib-Salut). Eight-hundred and seventy-one subacute and chronic NP, TP and LBP patients treated in Ib-Salut, who underwent NRT during 2011. A shared risk contract (SRC) was developed, where payments for NRT were linked to results on patients’ clinical evolution, reduction in medication and proportion of patients undergoing spinal surgery. Main outcome measures were local pain (NP, TP or LBP), referred pain, LBP-related disability and NP-related disability, measured using previously validated instruments at referral and 3 months later, use of medication assessed at referral and discharge, and rates of spinal surgery prescription after undergoing NRT. Results Median improvements at discharge corresponded to 57.1% of baseline value for local pain, 75.0% for referred pain, 53.8% for LBP-related disability and 45.0% for NP-related disability. Patients taking medication at discharge represented 29.0% of those taking it at referral. The proportion of patients in whom spinal surgery was prescribed after undergoing NRT was 0%. These results were consistent with those from previous randomised controlled trials (RCTs) and studies in routine practice, and complied with the standards set in the SRC. Conclusions It is feasible and effective to enhance post adoption surveillance methods with risk sharing tools to improve quality control and support value-based reimbursement decisions for NRT. The feasibility of generalising this approach to other settings and to other non

  8. Design of a symmetry controller for cycling induced by electrical stimulation: preliminary results on post-acute stroke patients.

    PubMed

    Ambrosini, Emilia; Ferrante, Simona; Schauer, Thomas; Ferrigno, Giancarlo; Molteni, Franco; Pedrocchi, Alessandra

    2010-08-01

    This study deals with the design of a controller for cycling induced by functional electrical stimulation. The controller will be exploitable in the rehabilitation of hemiparetic patients who need to recover motor symmetry. It uses the pulse width as the control variable in the stimulation of the two legs in order to nullify the unbalance between the torques produced at the two crank arms. It was validated by means of isokinetic trials performed both by healthy subjects and stroke patients. The results showed that the controller was able to reach, and then maintain, a symmetrical pedaling. In the future, the controller will be validated on a larger number of stroke patients.

  9. Design of a symmetry controller for cycling induced by electrical stimulation: preliminary results on post-acute stroke patients.

    PubMed

    Ambrosini, Emilia; Ferrante, Simona; Schauer, Thomas; Ferrigno, Giancarlo; Molteni, Franco; Pedrocchi, Alessandra

    2010-08-01

    This study deals with the design of a controller for cycling induced by functional electrical stimulation. The controller will be exploitable in the rehabilitation of hemiparetic patients who need to recover motor symmetry. It uses the pulse width as the control variable in the stimulation of the two legs in order to nullify the unbalance between the torques produced at the two crank arms. It was validated by means of isokinetic trials performed both by healthy subjects and stroke patients. The results showed that the controller was able to reach, and then maintain, a symmetrical pedaling. In the future, the controller will be validated on a larger number of stroke patients. PMID:20528850

  10. Post-traumatic distal humerus non-union : Open reduction and internal fixation: long-term results.

    PubMed

    Allende, Christian; Allende, Bartolomé T

    2009-10-01

    The objective of this paper is to evaluate the long-term functional results achieved after open reduction and internal fixation of 24 distal humerus non-unions. Non-unions were extra-articular-extracapsular (11 cases), extra-articular-intracapsular (8 cases) and intra-articular (5 cases). Preoperative elbow range of motion averaged 45 degrees. Time between original trauma and revision surgery averaged 14 months. Stabilisation methods varied according to type and location of the non-union. Follow-up averaged 46 months (range: 18-108). Elbow range of motion at last examination averaged 98 degrees . Flexion averaged 110 degrees and extension loss averaged 17 degrees . The disabilities of the arm, shoulder and hand (DASH) score averaged 16 points. Secondary transposition of the ulnar nerve was necessary in three cases. Sixteen patients reported no pain at last examination, seven had mild pain and one had moderate pain. Distal humerus non-unions present different characteristics; consequently, surgical treatment must be individualised for each patient. Even though they are demanding procedures, bony union and good long-term functional results were achieved.

  11. The post-Triassic evolution of the Sorgenfrei Tornquist Zone — results from thermo-mechanical modelling

    NASA Astrophysics Data System (ADS)

    Hansen, D. L.; Nielsen, S. B.; Lykke-Andersen, H.

    2000-12-01

    The Sorgenfrei-Tornquist Zone (STZ) is part of the Fennoscandian Border Zone separating the Danish Basin from the Fennoscandian Shield. The STZ as a structural element is of Palaeozoic origin and represents the north-westerly segment of the Tornquist-Teisseyre Zone, which separates the younger West European crust from the older East European Platform and extends from the Black Sea to the eastern North Sea area. The STZ was reactivated in Triassic-Jurassic extension and Late Cretaceous and Paleogene compression. This paper investigates the regional geological consequences of the reactivations by quantitative modelling along a profile across the STZ in the Danish area. The numerical model invokes elastic, viscous and plastic deformations of the lithosphere as well as surface processes governed by erosion, sedimentation and lateral transport under the influence of eustatic sea level variations and regional isostatic compensation. Surface processes and lithospheric mechanics are coupled through thermal blanketing effects and loading. The results, in general, address the regional geological consequences of the existence of intracontinental zones of structural weakness. More specifically the results show that the Late Cretaceous and Paleogene chalk depocentres in the Danish Basin are a direct consequence of the inversion of the STZ, and that the STZ inversion together with falling sea level in Cenozoic time are amongst the principal controlling factors in the geological evolution in the eastern North Sea area.

  12. Worldwide Evaluations of Quinoa: Preliminary Results from Post International Year of Quinoa FAO Projects in Nine Countries.

    PubMed

    Bazile, Didier; Pulvento, Cataldo; Verniau, Alexis; Al-Nusairi, Mohammad S; Ba, Djibi; Breidy, Joelle; Hassan, Layth; Mohammed, Maarouf I; Mambetov, Omurbek; Otambekova, Munira; Sepahvand, Niaz Ali; Shams, Amr; Souici, Djamel; Miri, Khaled; Padulosi, Stefano

    2016-01-01

    Chenopodium quinoa Willd., a high quality grain crop, is resistant to abiotic stresses (drought, cold, and salt) and offers an optimal source of protein. Quinoa represents a symbol of crop genetic diversity across the Andean region. In recent years, this crop has undergone a major expansion outside its countries of origin. The activities carried out within the framework of the International Year of Quinoa provided a great contribution to raise awareness on the multiple benefits of quinoa as well as to its wider cultivation at the global level. FAO is actively involved in promoting and evaluating the cultivation of quinoa in 26 countries outside the Andean region with the aim to strengthen food and nutrition security. The main goal of this research is to evaluate the adaptability of selected quinoa genotypes under different environments outside the Andean region. This paper presents the preliminary results from nine countries. Field evaluations were conducted during 2013/2014 and 2014/2015 in Asia (Kyrgyzstan and Tajikistan), and the Near East and North African countries (Algeria, Egypt, Iraq, Iran, Lebanon, Mauritania, and Yemen). In each country, the trials were carried out in different locations that globally represent the diversity of 19 agrarian systems under different agro-ecological conditions. Twenty-one genotypes of quinoa were tested using the same experimental protocol in all locations consisting in a randomized complete block design (RCBD) with three replicates. Some genotypes showed higher yields and the Q18 and Q12 landraces displayed greater adaptation than others to new environmental conditions. The Q21 and Q26 landraces were evaluated with stable and satisfactory levels of yield (>1 t.ha(-1)) in each of the different trial sites. This production stability is of considerable importance especially under climate change uncertainty. While these results suggest that this Andean crop is able to grow in many different environments, social, and cultural

  13. Worldwide Evaluations of Quinoa: Preliminary Results from Post International Year of Quinoa FAO Projects in Nine Countries

    PubMed Central

    Bazile, Didier; Pulvento, Cataldo; Verniau, Alexis; Al-Nusairi, Mohammad S.; Ba, Djibi; Breidy, Joelle; Hassan, Layth; Mohammed, Maarouf I.; Mambetov, Omurbek; Otambekova, Munira; Sepahvand, Niaz Ali; Shams, Amr; Souici, Djamel; Miri, Khaled; Padulosi, Stefano

    2016-01-01

    Chenopodium quinoa Willd., a high quality grain crop, is resistant to abiotic stresses (drought, cold, and salt) and offers an optimal source of protein. Quinoa represents a symbol of crop genetic diversity across the Andean region. In recent years, this crop has undergone a major expansion outside its countries of origin. The activities carried out within the framework of the International Year of Quinoa provided a great contribution to raise awareness on the multiple benefits of quinoa as well as to its wider cultivation at the global level. FAO is actively involved in promoting and evaluating the cultivation of quinoa in 26 countries outside the Andean region with the aim to strengthen food and nutrition security. The main goal of this research is to evaluate the adaptability of selected quinoa genotypes under different environments outside the Andean region. This paper presents the preliminary results from nine countries. Field evaluations were conducted during 2013/2014 and 2014/2015 in Asia (Kyrgyzstan and Tajikistan), and the Near East and North African countries (Algeria, Egypt, Iraq, Iran, Lebanon, Mauritania, and Yemen). In each country, the trials were carried out in different locations that globally represent the diversity of 19 agrarian systems under different agro-ecological conditions. Twenty-one genotypes of quinoa were tested using the same experimental protocol in all locations consisting in a randomized complete block design (RCBD) with three replicates. Some genotypes showed higher yields and the Q18 and Q12 landraces displayed greater adaptation than others to new environmental conditions. The Q21 and Q26 landraces were evaluated with stable and satisfactory levels of yield (>1 t.ha−1) in each of the different trial sites. This production stability is of considerable importance especially under climate change uncertainty. While these results suggest that this Andean crop is able to grow in many different environments, social, and cultural

  14. Worldwide Evaluations of Quinoa: Preliminary Results from Post International Year of Quinoa FAO Projects in Nine Countries.

    PubMed

    Bazile, Didier; Pulvento, Cataldo; Verniau, Alexis; Al-Nusairi, Mohammad S; Ba, Djibi; Breidy, Joelle; Hassan, Layth; Mohammed, Maarouf I; Mambetov, Omurbek; Otambekova, Munira; Sepahvand, Niaz Ali; Shams, Amr; Souici, Djamel; Miri, Khaled; Padulosi, Stefano

    2016-01-01

    Chenopodium quinoa Willd., a high quality grain crop, is resistant to abiotic stresses (drought, cold, and salt) and offers an optimal source of protein. Quinoa represents a symbol of crop genetic diversity across the Andean region. In recent years, this crop has undergone a major expansion outside its countries of origin. The activities carried out within the framework of the International Year of Quinoa provided a great contribution to raise awareness on the multiple benefits of quinoa as well as to its wider cultivation at the global level. FAO is actively involved in promoting and evaluating the cultivation of quinoa in 26 countries outside the Andean region with the aim to strengthen food and nutrition security. The main goal of this research is to evaluate the adaptability of selected quinoa genotypes under different environments outside the Andean region. This paper presents the preliminary results from nine countries. Field evaluations were conducted during 2013/2014 and 2014/2015 in Asia (Kyrgyzstan and Tajikistan), and the Near East and North African countries (Algeria, Egypt, Iraq, Iran, Lebanon, Mauritania, and Yemen). In each country, the trials were carried out in different locations that globally represent the diversity of 19 agrarian systems under different agro-ecological conditions. Twenty-one genotypes of quinoa were tested using the same experimental protocol in all locations consisting in a randomized complete block design (RCBD) with three replicates. Some genotypes showed higher yields and the Q18 and Q12 landraces displayed greater adaptation than others to new environmental conditions. The Q21 and Q26 landraces were evaluated with stable and satisfactory levels of yield (>1 t.ha(-1)) in each of the different trial sites. This production stability is of considerable importance especially under climate change uncertainty. While these results suggest that this Andean crop is able to grow in many different environments, social, and cultural

  15. Post-fire erosion risk mapping using Landsat TM: results from the case of 2007 fire in Mt. Parnitha Greece

    NASA Astrophysics Data System (ADS)

    Mavrakakis, G.; Petropoulos, G. P.; Papanikolaou, I.; Kairis, O.

    2012-04-01

    Wildfires have significant geomorphological and hydrological impacts, such as the increasing of soil erosion and instability phenomena to fire-affected environment. In comparison to traditional methods, such as field inventories, remote sensing provides a cost-effective and rapid option in mapping the spatial and temporal variability of wildfires. The influence of the wildfires to soil erosion / sediment transport and their impact to the erosional and depositional environment and equilibrium and overall to the longer-term geological framework is often neglected in these studies. In this study, we examine whether the absence of vegetation due to the wildfires is indeed the main triggering mechanism for high erosional rates and try to quantify these parameters. In particular, the objective of the present study has been to assess the changes in soil erosion risk in Mediterranean setting as a result of a wildfire using remote sensing and Geographical Information Systems (GIS). As a case study is selected an area located close to the capital of Greece, in which a destructive wildland fire occurred in the summer of 2007, a year of the most catastrophic fires occurred in Greece in recent times. Landsat TM satellite imagery available before and shortly after the firebreak was utilised. Erosion risk maps before and after the fire event were estimated on the basis of the Revised Universal Soil Loss Equation (RUSLE) model. Ancillary data used in RUSLE implementation included the ASTER Global Digital Elevation Model, a geology map and field inventory conducted in the studied region. A soil erosion risk map with five classes (very low, low, medium, high) before and after the fire event was eventually developed from RUSLE within a GIS environment. In overall, areas having a minimal soil erosion risk before the fire showed a considerable increase in erosion risk after the fire, as a result of natural environment destruction occurred from the fire outbreak. Soil erosion risk

  16. National Scale-up of Zinc Promotion in Nepal: Results from a Post-project Population-based Survey

    PubMed Central

    MacDonald, Vicki M.; Paudel, Mahesh; Banke, Kathryn K.

    2011-01-01

    The World Health Organization and the United Nations Children's Fund recommend using a new oral rehydration solution (ORS) plus zinc supplementation for 10-14 days for the treatment of diarrhoea in children aged less than five years. The Social Marketing Plus for Diarrhoeal Disease Control: Point of Use Water Disinfection and Zinc Treatment (POUZN) project in Nepal was one of the first zinc-promotion projects to move beyond pilot efforts into a scaled-up programme with national-level reach. This study used data from a survey conducted in 26 districts in Nepal in 2008 to examine zinc-use behaviour, knowledge, and beliefs of caregivers of children aged less than six years, other diarrhoea-treatment practices, and recollection of project communication messages. The results of the survey indicated that, by six months following the onset of a zinc-promotion campaign, the majority (67.5%) of children (n=289), aged less than six years, with diarrhoea were treated with ORS, and 15.4% were treated with zinc. Over half (53.1%) of all caregivers (n=3,550) interviewed had heard about zinc products; most (97.1%) of those who had heard of zinc knew that zinc should be used for the treatment of diarrhoea. Zinc-related knowledge and behaviours were positively associated with recall of communication messages. Children whose caregivers recalled the mass-media message that zinc should be used for 10 days [odds ratio (OR)=2.02, 95% confidence interval (CI) 1.85-2.19] and whose caregivers perceived that zinc is easy to obtain (OR=1.76, 95% CI 1.49-2.09) were more likely to be treated with zinc for 10 days, along with ORS. The findings demonstrated that mass media play an important role in increasing caregivers’ knowledge about zinc and encouraging trial and correct use. Future efforts should also focus on understanding the factors that motivate providers to continue recommending antibiotics and antidiarrhoeals instead of zinc. These findings are being used for informing the design

  17. Pre- or post-treatment with ethanol and ethyl pyruvate results in distinct anti-inflammatory responses of human lung epithelial cells triggered by interleukin-6.

    PubMed

    Relja, Borna; Omid, Nina; Schaible, Alexander; Perl, Mario; Meier, Simon; Oppermann, Elsie; Lehnert, Mark; Marzi, Ingo

    2015-08-01

    Increased local and systemic levels of interleukin (IL)-6 are associated with inflammatory processes, including neutrophil infiltration of the alveolar space, resulting in lung injury. Our previous study demonstrated the beneficial anti-inflammatory effects of acute exposure to ethanol (EtOH) in an acute in vivo model of inflammation. However, due to its side-effects, EtOH is not used clinically. In the present study, the effects of EtOH and ethyl pyruvate (EtP) as an alternative anti-inflammatory drug prior to and following application of an IL-6 stimulus on cultured A549 lung epithelial cells were compared, and it was hypothesized that treatment with EtOH and EtP reduces the inflammatory potential of the A549 cells. Time- and dose-dependent release of IL-8 from the A549 cells was observed following stimulation with IL-6. The release of IL-8 from the A549 cells was assessed following treatment with EtP (2.5-10 mM), sodium pyruvate (NaP; 10 mM) or EtOH (85-170 mM) for 1, 24 or 72 h, prior to and following IL-6 stimulation. The adhesion capacities of neutrophils to the treated A549 cells, and the expression levels of cluster of differentiation (CD)54 by the epithelial cells were measured. Treatment of the A549 cells with either EtOH or EtP significantly reduced the IL-6-induced release of IL-8. This effect was observed in the pre- and post-stimulatory conditions, which is of therapeutic importance. Similar data was revealed regarding the IL-6-induced neutrophil adhesion to the treated A549 cells, in which pre- and post-treatment with EtOH or EtP decreased the adhesion capacity, however, the results were dependent on the duration of incubation. Incubation durations of 1 and 24 h decreased the adhesion rates of neutrophils to the stimulated A549 cells, however, the reduction was only significant at 72 h post-treatment. The expression of CD54 was reduced only following treatment for 24 h with either EtOH or EtP, prior to IL-6 stimulation. Therefore, EtOH and Et

  18. Results of the post remedial action survey of areas 4 through 10 at the former Kellex site in Jersey City, New Jersey

    SciTech Connect

    Clark, C.; Berven, B.A.; Cottrell, W.D.; Goldsmith, W.A.

    1982-01-01

    A post remedial action survey was conducted at the former Kellex Corporation Research Facility in Jersey City, New Jersey. The Kellex facility was involved in the Manhattan Project, particularly in the area of engineering research in gaseous diffusion for uranium enrichment. As a result of those operations, this site was included by the US Department of Energy (DOE) in their Formerly Utilized Sites Remedial Action Program (FUSRAP). During comprehensive radiological surveys conducted by Oak Ridge National Laboratory in the summer of 1979, ten areas were located with levels of radionuclides in soil in excess of DOE criteria. This report describes the results of radiological surveys conducted in seven of these locations (Areas 4 to 10) following remedial action. Results of these surveys indicate that remedial action was successful in reducing radioactive contamination in these areas to criteria values established by DOE. 7 references, 19 figures, 31 tables.

  19. Post-amputation pain is associated with the recall of an impaired body representation in dreams-results from a nation-wide survey on limb amputees.

    PubMed

    Bekrater-Bodmann, Robin; Schredl, Michael; Diers, Martin; Reinhard, Iris; Foell, Jens; Trojan, Jörg; Fuchs, Xaver; Flor, Herta

    2015-01-01

    The experience of post-amputation pain such as phantom limb pain (PLP) and residual limb pain (RLP), is a common consequence of limb amputation, and its presence has negative effects on a person's well-being. The continuity hypothesis of dreams suggests that the presence of such aversive experiences in the waking state should be reflected in dream content, with the recalled body representation reflecting a cognitive proxy of negative impact. In the present study, we epidemiologically assessed the presence of post-amputation pain and other amputation-related information as well as recalled body representation in dreams in a sample of 3,234 unilateral limb amputees. Data on the site and time of amputation, residual limb length, prosthesis use, lifetime prevalence of mental disorders, presence of post-amputation pain, and presence of non-painful phantom phenomena were included in logistic regression analyses using recalled body representation in dreams (impaired, intact, no memory) as dependent variable. The effects of age, sex, and frequency of dream recall were controlled for. About 22% of the subjects indicated that they were not able to remember their body representation in dreams, another 24% of the amputees recalled themselves as always intact, and only a minority of less than 3% recalled themselves as always impaired. Almost 35% of the amputees dreamed of themselves in a mixed fashion. We found that lower-limb amputation as well as the presence of PLP and RLP was positively associated with the recall of an impaired body representation in dreams. The presence of non-painful phantom phenomena, however, had no influence. These results complement previous findings and indicate complex interactions of physical body appearance and mental body representation, probably modulated by distress in the waking state. The findings are discussed against the background of alterations in cognitive processes after amputation and hypotheses suggesting an innate body model.

  20. Post-amputation pain is associated with the recall of an impaired body representation in dreams-results from a nation-wide survey on limb amputees.

    PubMed

    Bekrater-Bodmann, Robin; Schredl, Michael; Diers, Martin; Reinhard, Iris; Foell, Jens; Trojan, Jörg; Fuchs, Xaver; Flor, Herta

    2015-01-01

    The experience of post-amputation pain such as phantom limb pain (PLP) and residual limb pain (RLP), is a common consequence of limb amputation, and its presence has negative effects on a person's well-being. The continuity hypothesis of dreams suggests that the presence of such aversive experiences in the waking state should be reflected in dream content, with the recalled body representation reflecting a cognitive proxy of negative impact. In the present study, we epidemiologically assessed the presence of post-amputation pain and other amputation-related information as well as recalled body representation in dreams in a sample of 3,234 unilateral limb amputees. Data on the site and time of amputation, residual limb length, prosthesis use, lifetime prevalence of mental disorders, presence of post-amputation pain, and presence of non-painful phantom phenomena were included in logistic regression analyses using recalled body representation in dreams (impaired, intact, no memory) as dependent variable. The effects of age, sex, and frequency of dream recall were controlled for. About 22% of the subjects indicated that they were not able to remember their body representation in dreams, another 24% of the amputees recalled themselves as always intact, and only a minority of less than 3% recalled themselves as always impaired. Almost 35% of the amputees dreamed of themselves in a mixed fashion. We found that lower-limb amputation as well as the presence of PLP and RLP was positively associated with the recall of an impaired body representation in dreams. The presence of non-painful phantom phenomena, however, had no influence. These results complement previous findings and indicate complex interactions of physical body appearance and mental body representation, probably modulated by distress in the waking state. The findings are discussed against the background of alterations in cognitive processes after amputation and hypotheses suggesting an innate body model. PMID

  1. Determination of medicinal and illicit drugs in post mortem dental hard tissues and comparison with analytical results for body fluids and hair samples.

    PubMed

    Klima, Miriam; Altenburger, Markus J; Kempf, Jürgen; Auwärter, Volker; Neukamm, Merja A

    2016-08-01

    In burnt or skeletonized bodies dental hard tissue sometimes is the only remaining specimen available. Therefore, it could be used as an alternative matrix in post mortem toxicology. Additionally, analysis of dental tissues could provide a unique retrospective window of detection. For forensic interpretation, routes and rates of incorporation of different drugs as well as physicochemical differences between tooth root, tooth crown and carious material have to be taken into account. In a pilot study, one post mortem tooth each from three drug users was analyzed for medicinal and illicit drugs. The pulp was removed in two cases; in one case the tooth was root canal treated. The teeth were separated into root, crown and carious material and drugs were extracted from the powdered material with methanol under ultrasonication. The extracts were screened for drugs by LC-MS(n) (ToxTyper™) and quantitatively analyzed with LC-ESI-MS/MS in MRM mode. The findings were compared to the analytical results for cardiac blood, femoral blood, urine, stomach content and hair. In dental hard tissues, 11 drugs (amphetamine, MDMA, morphine, codeine, norcodeine, methadone, EDDP, fentanyl, tramadol, diazepam, nordazepam, and promethazine) could be detected and concentrations ranged from approximately 0.13pg/mg to 2,400pg/mg. The concentrations declined in the following order: carious material>root>crown. Only the root canal treated tooth showed higher concentrations in the crown than in the root. In post mortem toxicology, dental hard tissue could be a useful alternative matrix facilitating a more differentiated consideration of drug consumption patterns, as the window of detection seems to overlap those for body fluids and hair. PMID:26930453

  2. Post-Amputation Pain Is Associated with the Recall of an Impaired Body Representation in Dreams—Results from a Nation-Wide Survey on Limb Amputees

    PubMed Central

    Bekrater-Bodmann, Robin; Schredl, Michael; Diers, Martin; Reinhard, Iris; Foell, Jens; Trojan, Jörg; Fuchs, Xaver; Flor, Herta

    2015-01-01

    The experience of post-amputation pain such as phantom limb pain (PLP) and residual limb pain (RLP), is a common consequence of limb amputation, and its presence has negative effects on a person’s well-being. The continuity hypothesis of dreams suggests that the presence of such aversive experiences in the waking state should be reflected in dream content, with the recalled body representation reflecting a cognitive proxy of negative impact. In the present study, we epidemiologically assessed the presence of post-amputation pain and other amputation-related information as well as recalled body representation in dreams in a sample of 3,234 unilateral limb amputees. Data on the site and time of amputation, residual limb length, prosthesis use, lifetime prevalence of mental disorders, presence of post-amputation pain, and presence of non-painful phantom phenomena were included in logistic regression analyses using recalled body representation in dreams (impaired, intact, no memory) as dependent variable. The effects of age, sex, and frequency of dream recall were controlled for. About 22% of the subjects indicated that they were not able to remember their body representation in dreams, another 24% of the amputees recalled themselves as always intact, and only a minority of less than 3% recalled themselves as always impaired. Almost 35% of the amputees dreamed of themselves in a mixed fashion. We found that lower-limb amputation as well as the presence of PLP and RLP was positively associated with the recall of an impaired body representation in dreams. The presence of non-painful phantom phenomena, however, had no influence. These results complement previous findings and indicate complex interactions of physical body appearance and mental body representation, probably modulated by distress in the waking state. The findings are discussed against the background of alterations in cognitive processes after amputation and hypotheses suggesting an innate body model. PMID

  3. Determination of medicinal and illicit drugs in post mortem dental hard tissues and comparison with analytical results for body fluids and hair samples.

    PubMed

    Klima, Miriam; Altenburger, Markus J; Kempf, Jürgen; Auwärter, Volker; Neukamm, Merja A

    2016-08-01

    In burnt or skeletonized bodies dental hard tissue sometimes is the only remaining specimen available. Therefore, it could be used as an alternative matrix in post mortem toxicology. Additionally, analysis of dental tissues could provide a unique retrospective window of detection. For forensic interpretation, routes and rates of incorporation of different drugs as well as physicochemical differences between tooth root, tooth crown and carious material have to be taken into account. In a pilot study, one post mortem tooth each from three drug users was analyzed for medicinal and illicit drugs. The pulp was removed in two cases; in one case the tooth was root canal treated. The teeth were separated into root, crown and carious material and drugs were extracted from the powdered material with methanol under ultrasonication. The extracts were screened for drugs by LC-MS(n) (ToxTyper™) and quantitatively analyzed with LC-ESI-MS/MS in MRM mode. The findings were compared to the analytical results for cardiac blood, femoral blood, urine, stomach content and hair. In dental hard tissues, 11 drugs (amphetamine, MDMA, morphine, codeine, norcodeine, methadone, EDDP, fentanyl, tramadol, diazepam, nordazepam, and promethazine) could be detected and concentrations ranged from approximately 0.13pg/mg to 2,400pg/mg. The concentrations declined in the following order: carious material>root>crown. Only the root canal treated tooth showed higher concentrations in the crown than in the root. In post mortem toxicology, dental hard tissue could be a useful alternative matrix facilitating a more differentiated consideration of drug consumption patterns, as the window of detection seems to overlap those for body fluids and hair.

  4. Effectiveness and safety of post-induction phase bevacizumab treatment for patients with non-small-cell lung cancer: results from the ARIES observational cohort study.

    PubMed

    Kosty, Michael P; Wozniak, Antoinette J; Jahanzeb, Mohammad; Leon, Larry; Fish, Susan; Hazard, Sebastien J; Lynch, Thomas J

    2015-12-01

    Data from randomized, controlled trials suggest that post-induction phase (IP) treatment with bevacizumab may benefit patients with advanced non-small-cell lung cancer (NSCLC). Real-world clinical practice, however, can involve variable use and patterns of treatment in broader patient populations. To assess the effect of bevacizumab on post-IP overall survival (OS) following IP chemotherapy + bevacizumab, analyses were conducted in patients enrolled in the Avastin(®) Registry--Investigation of Effectiveness and Safety (ARIES) observational cohort study (OCS) who received post-IP bevacizumab. ARIES was a large, prospective OCS of patients who received chemotherapy in combination with bevacizumab for the first-line treatment of NSCLC. This unplanned, post hoc analysis included patients who received chemotherapy and bevacizumab and who did not have progressive disease through the completion of IP treatment. A dichotomous analysis compared outcomes in patients who did and did not receive bevacizumab before a landmark date of day 30 post IP. A cumulative exposure analysis used a time-dependent Cox regression model to assess the effect of cumulative post-IP bevacizumab exposure on post-IP OS. In the dichotomous analysis, the duration of post-IP OS was significantly longer in patients who received post-IP bevacizumab; median post-IP OS was 15.6 vs. 11.3 months, respectively (hazard ratio [HR] = 0.80; 95 % confidence interval 0.71-0.91; P < 0.001). The cumulative exposure analysis observed that each additional cycle of cumulative bevacizumab exposure decreased the HR for post-IP OS by 2.7 %, on average. In conclusion, post-IP bevacizumab exposure was associated with improved post-IP OS in patients with advanced NSCLC who were enrolled in the ARIES OCS.

  5. Uncertainty and sensitivity analysis within the post closure Performance and Safety Assessment of the French deep geological radwaste disposal: methodology, tool and examples of results

    NASA Astrophysics Data System (ADS)

    Pepin, G.

    2009-04-01

    Within the framework of the December 30, 1991 french act, Andra submitted to the French Parliament in December 2005 a report on the feasibility of a high-level and long-lived radwaste disposal in the Callovo-Oxfodien clay layer (Meuse/Haute-Marne site). Further to 2006 french act, Andra is now involved in licensing of the reversible disposal up to 2015, which requires a great scientific and technical knowledge. Studies are based on many years of research carried out in France, in particular in Andra's Meuse/Haute-Marne Underground Research Laboratory (MHM URL), and international programs on radwastes, engineered barriers and deep clay formations. Intensive programs on hydraulic, solute transfer and radionuclides behaviour (solubility, retention) were and are carried out on Callovo-Oxfordian argilites (undisturbed and damaged), concrete materials and swelling clay based material, in order to provide a sound database. All these data allowed to perform firstly a sound description of the expected phenomenological evolution of the repository and its geological environment (including release and migration of radionuclides) from operating period to post closure period up to one million years, secondly a sound post-closure performance and safety assessment covering the different waste types (ILLW, HLW). Various safety scenarii were defined to quantify radiological impacts and to evaluate performance of the components and safety functions in post closure using specific indicators (concentration, molar rate, water flux…). According to the RFS III2.f (french safety rule related to deep geological radwaste disposad), there is no risk analysis in post closure and assessments are performed using deterministic situations, models and values. To complete analysis, propagation of uncertainties from models and input data in Performance and Safey Assessment (PA/SA) models is done using both deterministic and multiparametric probabilistic approach, with two main objectives: (i) to

  6. Decitabine reduces transfusion dependence in older patients with acute myeloid leukemia: results from a post hoc analysis of a randomized phase III study.

    PubMed

    He, Jianming; Xiu, Liang; De Porre, Peter; Dass, Ramesh; Thomas, Xavier

    2015-04-01

    This post hoc analysis of the DACO-016 phase III study evaluates the impact of decitabine on transfusion dependence and survival in 485 elderly patients with newly diagnosed acute myeloid leukemia (AML). Red blood cell (RBC) and platelet (PLT) transfusion independence, defined as no transfusions for ≥ 8 consecutive weeks, was measured in both decitabine (n = 242) and treatment choice (TC, n = 243) arms. More RBC transfusion dependent patients at baseline became transfusion independent with decitabine than with TC (26% vs. 13%; p = 0.0026). Similar results were obtained for patients who were PLT transfusion dependent at baseline (31% vs. 13%; p = 0.0069). When excluding patients who attained complete remission (CR), survival was improved in patients who achieved RBC or PLT transfusion independence, suggesting that reaching CR is not a prerequisite for deriving benefit from treatment with decitabine. In addition, patients who achieved transfusion independence with decitabine had increased treatment continuation, even in the absence of CR.

  7. Simultaneous post-transcriptional gene silencing of two different chalcone synthase genes resulting in pure white flowers in the octoploid dahlia.

    PubMed

    Ohno, Sho; Hosokawa, Munetaka; Kojima, Misa; Kitamura, Yoshikuni; Hoshino, Atsushi; Tatsuzawa, Fumi; Doi, Motoaki; Yazawa, Susumu

    2011-11-01

    Garden dahlias (Dahlia variabilis) are autoallooctoploids with redundant genes producing wide color variations in flowers. There are no pure white dahlia cultivars, despite its long breeding history. However, the white areas of bicolor flower petals appear to be pure white. The objective of this experiment was to elucidate the mechanism by which the pure white color is expressed in the petals of some bicolor cultivars. A pigment analysis showed that no flavonoid derivatives were detected in the white areas of petals in a star-type cultivar 'Yuino' and the two seedling cultivars 'OriW1' and 'OriW2' borne from a red-white bicolor cultivar, 'Orihime', indicating that their white areas are pure white. Semi-quantitative RT-PCR showed that in the pure white areas, transcripts of two chalcone synthases (CHS), DvCHS1 and DvCHS2 which share 69% nucleotide similarity with each other, were barely detected. Premature mRNA of DvCHS1 and DvCHS2 were detected, indicating that these two CHS genes are silenced post-transcriptionally. RNA gel blot analysis revealed that small interfering RNAs (siRNAs) derived from CHSs were produced in these pure white areas. By high-throughput sequence analysis of small RNAs in the pure white areas with no mismatch acceptance, small RNAs were mapped to two alleles of DvCHS1 and two alleles of DvCHS2 expressed in 'Yuino' petals. Therefore, we concluded that simultaneous siRNA-mediated post-transcriptional gene silencing of redundant CHS genes results in the appearance of pure white color in dahlias.

  8. Simultaneous post-transcriptional gene silencing of two different chalcone synthase genes resulting in pure white flowers in the octoploid dahlia.

    PubMed

    Ohno, Sho; Hosokawa, Munetaka; Kojima, Misa; Kitamura, Yoshikuni; Hoshino, Atsushi; Tatsuzawa, Fumi; Doi, Motoaki; Yazawa, Susumu

    2011-11-01

    Garden dahlias (Dahlia variabilis) are autoallooctoploids with redundant genes producing wide color variations in flowers. There are no pure white dahlia cultivars, despite its long breeding history. However, the white areas of bicolor flower petals appear to be pure white. The objective of this experiment was to elucidate the mechanism by which the pure white color is expressed in the petals of some bicolor cultivars. A pigment analysis showed that no flavonoid derivatives were detected in the white areas of petals in a star-type cultivar 'Yuino' and the two seedling cultivars 'OriW1' and 'OriW2' borne from a red-white bicolor cultivar, 'Orihime', indicating that their white areas are pure white. Semi-quantitative RT-PCR showed that in the pure white areas, transcripts of two chalcone synthases (CHS), DvCHS1 and DvCHS2 which share 69% nucleotide similarity with each other, were barely detected. Premature mRNA of DvCHS1 and DvCHS2 were detected, indicating that these two CHS genes are silenced post-transcriptionally. RNA gel blot analysis revealed that small interfering RNAs (siRNAs) derived from CHSs were produced in these pure white areas. By high-throughput sequence analysis of small RNAs in the pure white areas with no mismatch acceptance, small RNAs were mapped to two alleles of DvCHS1 and two alleles of DvCHS2 expressed in 'Yuino' petals. Therefore, we concluded that simultaneous siRNA-mediated post-transcriptional gene silencing of redundant CHS genes results in the appearance of pure white color in dahlias. PMID:21688014

  9. Post-Secondary Pathways of Non-Graduates from B.C. Grade 12. Research Results from the Student Transitions Project

    ERIC Educational Resources Information Center

    Beatty-Guenter, Patricia; Cowin, Bob

    2013-01-01

    The Student Transitions Project (STP) has focused its research since 2005 on the achievements of British Columbia (B.C.) grade 12 graduates who enrolled in post-secondary education. Some students who do not graduate from Grade 12 also enroll at post-secondary institutions in a variety of programs, but little has been reported on these…

  10. Modulation of farnesoid X receptor results in post-translational modification of poly (ADP-ribose) polymerase 1 in the liver

    SciTech Connect

    Zhu, Yan; Li, Guodong; Dong, Yafeng; Zhou, Helen H.; Kong, Bo; Aleksunes, Lauren M.; Richardson, Jason R.; Li, Fei; Guo, Grace L.

    2013-01-15

    The farnesoid X receptor (FXR) is a bile acid-activated transcription factor belonging to the nuclear receptor superfamily. FXR deficiency in mice results in cholestasis, metabolic disorders, and tumorigenesis in liver and intestine. FXR is known to contribute to pathogenesis by regulating gene transcription; however, changes in the post-transcriptional modification of proteins associated with FXR modulation have not been determined. In the current study, proteomic analysis of the livers of wild-type (WT) and FXR knockout (FXR-KO) mice treated with a FXR synthetic ligand or vehicle was performed. The results identified five proteins as novel FXR targets. Since FXR deficiency in mice leads to liver tumorigenesis, poly (ADP-ribose) polymerase family, member 1 (Parp1) that is important for DNA repair, was validated in the current study by quantitative real-time PCR, and 1- and 2-dimensional gel electrophoresis/western blot. The results showed that Parp1 mRNA levels were not altered by FXR genetic status or by agonist treatment. However, total Parp1 protein levels were increased in FXR-KO mice as early as 3 month old. Interestingly, total Parp1 protein levels were increased in WT mice in an age-dependent manner (from 3 to 18 months), but not in FXR-KO mice. Finally, activation of FXR in WT mice resulted in reduction of phosporylated Parp1 protein in the liver without affecting total Parp1 protein levels. In conclusion, this study reveals that FXR genetic status and agonist treatment affects basal levels and phosphorylation state of Parp1, respectively. These alterations, in turn, may be associated with the hepatobiliary alterations observed in FXR-KO mice and participate in FXR agonist-induced protection in the liver. -- Highlights: ► Proteomic analysis identified novel FXR targets. ► FXR modification altered post-translational modification of the Parp1 protein. ► Altered Parp1 function may contribute to mechanisms of FXR regulation of liver functions.

  11. Intermittent catheterization in the management of post spinal cord injury (SCI) neurogenic bladder using new hydrophilic, with lubrication in close circuit devices – our own preliminary results

    PubMed Central

    Spinu, A; Onose, G; Daia, C; Panţu, C; Anghelescu, A; Onose, L; Mihăescu, A

    2012-01-01

    This article is a review of the related approaches in the field – including the newest ones associated with a specific retrospective study on in-patients from our Clinic Division (preliminary results). Aim. Study design : To objectively assess whether there are significant differences regarding some specific key biological and psychometric parameters related to the use of hydrophilic catheters vs. non-hydrophilic ones. Materials and Methods: We have evaluated the outcomes of long term IC using by comparatively using the afore-mentioned two different types of catheters, on two lots (totally 45 patients with mainly retention type of neurogenic bladder): 30 post SCI patients, using exclusively hydrophilic catheters and respectively, 10 same kinds of patients that used exclusively non-hydrophilic catheters. Additionally, there were 5 patients included in both lots as they have started IC with non-hydrophilic catheters and since 2008 they have switched on using hydrophilic ones. The methods used were primary data acquisition based on a unitary questionnaire and statistical analyses. Results and discussion : Mainly: the patients that used exclusively hydrophilic type of catheters (median: “None”) vs. those using exclusively non-hydrophilic type of catheters (median: “One every 4 months”) presented: a significantly lower number of inflammatory episodes at scrotal level (p-value: 0.0001 WT), a significantly lower number of post/intra/inter catheterization bleeding episodes (p-value: 0.0001 WT), a very slightly lower number of UTI activations and expressed a significant higher satisfaction level (p-value <0.0001 WT). However, speculating a conceptual relation with the lower number of inflammatory episodes at scrotal level, it is to be thought that bigger lots of patients could provide, in this respect, significant results too. This study is to be continued, in order to further validate these preliminary, quite promising results, on bigger lots through the complex

  12. Normal results of post-race thallium-201 myocardial perfusion imaging in marathon runners with elevated serum MB creatine kinase levels

    SciTech Connect

    Siegel, A.J.; Silverman, L.M.; Holman, B.L.

    1985-10-01

    Elevated cardiac enzyme values in asymptomatic marathon runners after competition can arise from skeletal muscle through exertional rhabdomyolysis, silent injury to the myocardium, or a combined tissue source. Peak post-race levels of the MB isoenzyme of creatine kinase are similar to values in patients with acute myocardial infarction. Previously reported normal results of infarct-avid myocardial scintigraphy with technetium 99m pyrophosphate in runners after competition suggest a non-cardiac source but cannot exclude silent injury to the myocardium. Therefore, thallium 201 myocardial perfusion imaging was performed in runners immediately after competition together with determination of sequential cardiac enzyme levels. Among 15 runners tested, the average peak in serum MB creatine kinase 24 hours after the race was 128 IU/liter with a cumulative MB creatine kinase release of 117 IU/liter; these values are comparable to those in patients with acute transmural myocardial infarction. Thallium 201 myocardial scintigraphic results were normal in five runners randomly selected from those who volunteered for determination of sequential blood levels. It is concluded that elevations of serum MB creatine kinase in marathon runners arise from a skeletal muscle source and that thallium 201 myocardial scintigraphy is useful to assess runners for myocardial injury when clinical questions arise.

  13. Pegylated interferon in HBeAg-positive and -negative chronic hepatitis B patients: post-treatment 1-year results of three Turkish centres.

    PubMed

    Yamazhan, Tansu; Kurtaran, Behice; Pullukçu, Hüsnü; Yüksel, Esma; Özkaya, Deniz; Taşbakan, Meltem Işıkgöz; Sipahi, Oğuz Reşat; Durusoy, Raika; Aksu, Hasan Salih Zeki

    2014-12-01

    In this study, we aimed to evaluate the 1-year post-treatment follow-up results of 112 patients who received pegylated interferon (PEG-IFN) for 52 weeks. HBeAg negativity/seroconversion and/or negative HBV-DNA at the end of the treatment were considered as response. Patients who had response at the end of treatment but had HBV-DNA breakthrough during 1-year follow-up were considered as relapse. The study group comprised 112 cases (34 HBeAg-positive, 78 HBeAg-negative). In HBeAg-positive and -negative cases, end-of-treatment response rates were 2·9% and 60·2%, whereas 1-year sustained virological response rates were 0 and 33·3%, respectively. When we compared relapse cases versus cases with response at the end of 1-year follow-up, being female and having low viral load were the two parameters associated with higher response rates (Chi-square, P  =  0·028; Mann-Whitney U test, P  =  0·023). Overall non-response rates to PEG-IFN were high (57·1%). Results in HBeAg-positive cases were disappointing.

  14. A Post-Flight Comparison Between GPS Signal Generator and On-Orbit Testing Results from the STS-101 and STS-106 SOAR Shuttle Flight Experiment

    NASA Technical Reports Server (NTRS)

    Simpson, James; Gomez, Susan; Bauer, Frank H. (Technical Monitor)

    2001-01-01

    The use of a GPS Signal Generator (GPSSG) prior to launch for verification of a GPS subsystem and GN&C system on a spacecraft is becoming a very common practice. The level of confidence in the verification created by running a receiver with a GPSSG can greatly impact both schedule and cost of spacecraft development. This paper addresses the comparison of the Space Shuttle STS-101 and STS-106 Space Integrated GPS/INS (SIGI) Orbital Attitude Readiness (SOAR) flight experiments on-orbit performance with the performance from the same receiver on a Global Simulation Systems (GSS) GPSSG. The SOAR flight experiment was designed to demonstrate on-orbit performance of the International Space Station Force-19 GPS receiver. This paper discusses the process involved in getting the post-flight Best Estimate of Trajectory and Best Estimate of Attitude into the GPSSG such that the Force-19 receiver will experience the same trajectory and environmental conditions as observed during the SOAR flight experiment. Results of the comparison conclude with recommendations of how better to construct and interpret results from receiver tests using a GSS GPSSG.

  15. Analysis of factors influencing the overall effect of racecadotril on childhood acute diarrhea. Results from a real-world and post-authorization surveillance study in Venezuela

    PubMed Central

    Chacón, Jose

    2010-01-01

    Drug efficacy might differ from clinical trial results when performed in clinical daily conditions. Therefore, it is mandatory to conduct trials about effectiveness to improve external validity. This post-authorization, open-label, noncontrolled, prospective, multicenter, observational, and naturalistic trial was designed to search for factors influencing the racecadotril overall effect on childhood acute watery diarrhea in a real-world setting of Venezuela. There were 3,873 children with acute watery diarrhea treated with racecadotril, an enkephalin breakdown blocker plus oral rehydration therapy by 97 pediatricians. Evaluations were carried out daily until emission of two consecutive formed stools or absence of watery bowel movements for 24 hours. The primary end-point was time-to-relief, defined as the time from first racecadotril dose to the last watery bowel movement time. Age, gender, nursing type, nursing status during diarrhea, diarrhea severity, and co-medication were considered as factors in the statistical analysis. The primary end-point was evaluated by factors using UNIANOVA, and post-hoc tests were done. A multiple regression analysis was carried out to identify factors affecting drug performance, racecadotril effectiveness and tolerability overall assessment was searched by physicians and patients, and inter-observer agreement was evaluated by kappa statistics. The mean time-to-relief was 18.5 ± 12.5 hours [95% confidence interval 17.9–19.0] and the diarrhea severity was the only variable with significant and independent weight on racecadotril effectiveness explaining 23% of time-to-relief variance, but even in severe diarrhea cases this time was less than 24 hours. High agreement about satisfactory perception on effectiveness and tolerability was reached among physicians and patients. In conclusion, the racecadotril overall effect, evaluated in a real-world setting of Venezuela, was in agreement with results of some earlier controlled trials. It

  16. Post-chikungunya chronic inflammatory rheumatism: results from a retrospective follow-up study of 283 adult and child cases in La Virginia, Risaralda, Colombia

    PubMed Central

    Rodriguez-Morales, Alfonso J.; Gil-Restrepo, Andrés F.; Ramírez-Jaramillo, Valeria; Montoya-Arias, Cindy P.; Acevedo-Mendoza, Wilmer F.; Bedoya-Arias, Juan E.; Chica-Quintero, Laura A.; Murillo-García, David R.; García-Robledo, Juan E.; Castrillón-Spitia, Juan D.; Londoño, Jose J.; Bedoya-Rendón, Hector D.; Cárdenas-Pérez, Javier de Jesús; Cardona-Ospina, Jaime A.; Lagos-Grisales, Guillermo J.

    2016-01-01

    Objective: There are limited studies in Latin America regarding the chronic consequences of the Chikungunya virus (CHIK), such as post-CHIK chronic inflammatory rheumatism (pCHIK-CIR). We assessed the largest cohort so far of pCHIK-CIR in Latin America, at the municipality of La Virginia, Risaralda, a new endemic area of CHIK in Colombia. Methods: We conducted a cohort retrospective study in Colombia of 283 patients diagnosed with CHIK that persisted with pCHIK-CIR after a minimum of 6 weeks and up to a maximum of 26.1 weeks. pCHIK cases were identified according to validated criteria via telephone. Results: Of the total CHIK-infected subjects, 152 (53.7%) reported persistent rheumatological symptoms (pCHIK-CIR). All of these patients reported joint pains (chronic polyarthralgia, pCHIK-CPA), 49.5% morning stiffness, 40.6% joint edema, and 16.6% joint redness. Of all patients, 19.4% required and attended for care prior to the current study assessment (1.4% consulting rheumatologists). Significant differences in the frequency were observed according to age groups and gender. Patients aged >40 years old required more medical attention (39.5%) than those ≤40 years-old (12.1%) (RR=4.748, 95%CI 2.550-8.840). Conclusions: According to our results, at least half of the patients with CHIK developed chronic rheumatologic sequelae, and from those with pCHIK-CPA, nearly half presented clinical symptoms consistent with inflammatory forms of the disease. These results support previous estimates obtained from pooled data of studies in La Reunion (France) and India and are consistent with the results published previously from other Colombian cohorts in Venadillo (Tolima) and Since (Sucre). PMID:27081477

  17. Secular Slip, Regional, Coseismic Effects and Post-Seismic Deformation From the June 28, 1992 Landers Earthquake: Mojave Desert GPS Results

    NASA Technical Reports Server (NTRS)

    Miller, M.; Webb, F.; Townsend, D.; Golombek, M.; Dokka, R.

    1993-01-01

    This paper describes the constraints on long-term, post-seismic deformation within the Mojave Desert and on cumulative slip across the northern part of the Eastern California shear zone from May 1991 to August 1993.

  18. Epigenetic and phenotypic changes result from a continuous pre and post natal dietary exposure to phytoestrogens in an experimental population of mice

    PubMed Central

    Guerrero-Bosagna, Carlos M; Sabat, Pablo; Valdovinos, Fernanda S; Valladares, Luis E; Clark, Susan J

    2008-01-01

    Background Developmental effects of exposure to endocrine disruptors can influence adult characters in mammals, but could also have evolutionary consequences. The aim of this study was to simulate an environmental exposure of an experimental population of mice to high amounts of nutritional phytoestrogens and to evaluate parameters of relevance for evolutionary change in the offspring. The effect of a continuous pre- and post-natal exposure to high levels of dietary isoflavones was evaluated on sexual maturity, morphometric parameters and DNA methylation status in mice. Adult mice male/female couples were fed ad libitum either with control diet (standard laboratory chow) or ISF diet (control diet plus a soy isoflavone extract at 2% (w/w) that contained the phytoestrogens genistein and daidzein). In the offspring we measured: i) the onset of vaginal opening (sexual maturation) in females, ii) weight and size in all pups at 7, 14, 21 and 42 days post-natal (dpn) and iii) DNA methylation patterns in skeletal α-actin (Acta1), estrogen receptor-α and c-fos in adults (42 dpn). Results Vaginal opening was advanced in female pups in the ISF group, from 31.6 ± 0.75 dpn to 25.7 ± 0.48. No differences in size or weight at ages 7, 14 or 21 dpn were detected between experimental groups. Nevertheless, at age 42 dpn reduced size and weight were observed in ISF pups, in addition to suppression of normal gender differences in weight seen in the control group (males heavier that females). Also, natural differences seen in DNA methylation at Acta1 promoter in the offspring originated in the control group were suppressed in the ISF group. Acta1 is known to be developmentally regulated and related to morphomotric features. Conclusion This study demonstrates in mammals that individuals from a population subjected to a high consumption of isoflavones can show alterations in characters that may be of importance from an evolutionary perspective, such as epigenetic and morphometric

  19. [Response of Pharmaceutical Companies to the Crisis of Post-Marketing Clinical Trials of Anti-Cancer Agents -- Results of Questionnaires to Pharmaceutical Companies].

    PubMed

    Nakajima, Toshifusa

    2016-04-01

    Investigator-oriented post-marketing clinical trials of anti-cancer agents are faced to financial crisis due to drastic decrease in research-funds from pharmaceutical companies caused by a scandal in 2013. In order to assess the balance of research funds between 2012 and 2014, we made queries to 26 companies manufacturing anti-cancer agents, and only 10 of 26 responded to our queries. Decrease in the fund was observed in 5 of 10, no change in 1, increase in 3 and no answer in 1. Companies showed passive attitude to carry out doctor-oriented clinical trials of off-patent drugs or unapproved drugs according to advanced medical care B program, though some companies answered to proceed approved routines of these drugs if clinical trials showed good results. Most companies declined to make comments on the activity of Japan Agency for Medical Research and Development (AMED), but some insisted to produce good corroboration between AMED and pharmaceutical companies in order to improve the quality of trials. Further corroboration must be necessary for this purpose among researchers, governmental administrative organs, pharmaceutical companies, patients' groups, and mass-media.

  20. Ten Year Operating Test Results and Post-Test Analysis of a 1/10 Segment Stirling Sodium Heat Pipe, Phase III

    NASA Technical Reports Server (NTRS)

    Rosenfeld, John, H; Minnerly, Kenneth, G; Dyson, Christopher, M.

    2012-01-01

    High-temperature heat pipes are being evaluated for use in energy conversion applications such as fuel cells, gas turbine re-combustors, Stirling cycle heat sources; and with the resurgence of space nuclear power both as reactor heat removal elements and as radiator elements. Long operating life and reliable performance are critical requirements for these applications. Accordingly, long-term materials compatibility is being evaluated through the use of high-temperature life test heat pipes. Thermacore, Inc., has carried out a sodium heat pipe 10-year life test to establish long-term operating reliability. Sodium heat pipes have demonstrated favorable materials compatibility and heat transport characteristics at high operating temperatures in air over long time periods. A representative one-tenth segment Stirling Space Power Converter heat pipe with an Inconel 718 envelope and a stainless steel screen wick has operated for over 87,000 hr (10 yr) at nearly 700 C. These life test results have demonstrated the potential for high-temperature heat pipes to serve as reliable energy conversion system components for power applications that require long operating lifetime with high reliability. Detailed design specifications, operating history, and post-test analysis of the heat pipe and sodium working fluid are described.

  1. [Response of Pharmaceutical Companies to the Crisis of Post-Marketing Clinical Trials of Anti-Cancer Agents -- Results of Questionnaires to Pharmaceutical Companies].

    PubMed

    Nakajima, Toshifusa

    2016-04-01

    Investigator-oriented post-marketing clinical trials of anti-cancer agents are faced to financial crisis due to drastic decrease in research-funds from pharmaceutical companies caused by a scandal in 2013. In order to assess the balance of research funds between 2012 and 2014, we made queries to 26 companies manufacturing anti-cancer agents, and only 10 of 26 responded to our queries. Decrease in the fund was observed in 5 of 10, no change in 1, increase in 3 and no answer in 1. Companies showed passive attitude to carry out doctor-oriented clinical trials of off-patent drugs or unapproved drugs according to advanced medical care B program, though some companies answered to proceed approved routines of these drugs if clinical trials showed good results. Most companies declined to make comments on the activity of Japan Agency for Medical Research and Development (AMED), but some insisted to produce good corroboration between AMED and pharmaceutical companies in order to improve the quality of trials. Further corroboration must be necessary for this purpose among researchers, governmental administrative organs, pharmaceutical companies, patients' groups, and mass-media. PMID:27220801

  2. Repeat Confirmatory Testing for Persons with Discordant Whole Blood and Oral Fluid Rapid HIV Test Results: Findings from Post Marketing Surveillance

    PubMed Central

    Wesolowski, Laura G.; MacKellar, Duncan A.; Ethridge, Steven F.; Zhu, Julia H.; Owen, S. Michele; Sullivan, Patrick S.

    2008-01-01

    Background Reactive oral fluid and whole blood rapid HIV tests must be followed with a confirmatory test (Western blot (WB), immunofluorescent assay (IFA) or approved nucleic acid amplification test (NAAT)). When the confirmatory result is negative or indeterminate (i.e. discordant with rapid result), repeat confirmatory testing should be conducted using a follow-up specimen. Previous reports have not described whether repeat testing adequately resolves the HIV-infection status of persons with discordant results. Methodology Post-marketing surveillance was conducted in 368 testing sites affiliated with 14 state and 2 city health departments from August 11, 2004 to June 30, 2005 and one health department through December 31, 2005. For persons with discordant results, data were collected on demographics, risk behaviors, HIV test results and specimen types. Persons with repeat confirmatory results were classified as HIV-infected or uninfected. Regression models were created to assess risk factors for not having repeat testing. Principal Findings Of 167,371 rapid tests conducted, 2589 (1.6%) were reactive: of these, 2417 (93%) had positive WB/IFA, 172 (7%) had negative or indeterminate WB/IFA. Of 89/172 (52%) persons with a repeat confirmatory test: 17 (19%) were HIV-infected, including 3 with indeterminate WB and positive NAAT; 72 (81%) were uninfected, including 12 with repeat indeterminate WB. Factors associated with HIV-infection included having an initial indeterminate WB/IFA (vs. negative) (p<0.001) and having an initial oral fluid WB (vs. serum) (p<0.001). Persons who had male-female sex (vs. male-male sex) were at increased risk for not having a repeat test [adjusted OR 2.6, 95% CI (1.3, 4.9)]. Conclusions Though only half of persons with discordant results had repeat confirmatory testing, of those who did, nearly one in five were HIV-infected. These findings underscore the need for rapid HIV testing programs to increase repeat confirmatory testing for persons

  3. Conceptual Mobility of Geoscience Concepts in Introductory College-Level Courses: Results from Pre- and Post-testing with the Geoscience Concept Inventory

    NASA Astrophysics Data System (ADS)

    Anderson, S. W.; Libarkin, J.

    2012-12-01

    College-level teaching of Earth science concepts typically assumes students have a supporting-science conceptual framework and skills for visualizing in three dimensions. The Geoscience Concept Inventory (GCI) is an assessment instrument for measuring learning that includes questions from most geologic sub-disciplines, as well as some from supporting science areas. Several questions rely on the ability to interpret two and three dimensional situations. Nationwide pre- and post-testing of introductory Earth science courses with the Geoscience Concept Inventory show little gain for many of its questions. Analysis of matched tests shows that students are typically switching between wrong answers. Of the 22 GCI questions that showed a normalized gain of <0.03, 9 covered basic physics and chemistry principles. Half of the low gain questions had change rates within 20 percentage points of that expected for guessing, indicating that students have high conceptual mobility. These results also pertain to the high pre-test students, suggesting that little conceptual entrenchment occurs for many students enrolled in entry-level courses. We suggest that students may have difficulty settling on a correct geological conception because of the shaky supporting-science underpinnings upon which these ideas are built. These results prompt the following questions; when do our hydrology and other Earth science students learn fundamental science concepts, and what role does an introductory course play in this learning? We suggest that longitudinal studies are needed for time periods longer than a semester, and that more attention be paid to when conceptual change occurs for our advanced learners.

  4. Seven-year cost-effectiveness of ProDisc-C total disc replacement: results from investigational device exemption and post-approval studies.

    PubMed

    Radcliff, Kris; Lerner, Jason; Yang, Chao; Bernard, Thierry; Zigler, Jack E

    2016-05-01

    OBJECTIVE The purpose of this study was to evaluate the 7-year cost-effectiveness of cervical total disc replacement (CTDR) versus anterior cervical discectomy and fusion (ACDF) for the treatment of patients with single-level symptomatic degenerative disc disease. A change in the spending trajectory for spine care is to be achieved, in part, through the selection of interventions that have been proven effective yet cost less than other options. This analysis complements and builds upon findings from other cost-effectiveness evaluations of CTDR through the use of long-term, patient-level data from a randomized study. METHODS This was a 7-year health economic evaluation comparing CTDR versus ACDF from the US commercial payer perspective. Prospectively collected health care resource utilization and treatment effects (quality-adjusted life years [QALYs]) were obtained from individual patient-level adverse event reports and SF-36 data, respectively, from the randomized, multicenter ProDisc-C total disc replacement investigational device exemption (IDE) study and post-approval study. Statistical distributions for unit costs were derived from a commercial claims database and applied using Monte Carlo simulation. Patient-level costs and effects were modeled via multivariate probabilistic analysis. Confidence intervals for 7-year costs, effects, and net monetary benefit (NMB) were obtained using the nonparametric percentile method from results of 10,000 bootstrap simulations. The robustness of results was assessed through scenario analysis and within a parametric regression model controlling for baseline variables. RESULTS Seven-year follow-up data were available for more than 70% of the 209 randomized patients. In the base-case analysis, CTDR resulted in mean per-patient cost savings of $12,789 (95% CI $5362-$20,856) and per-patient QALY gains of 0.16 (95% CI -0.073 to 0.39) compared with ACDF over 7 years. CTDR was more effective and less costly in 90.8% of probabilistic

  5. Biological post

    PubMed Central

    Kumar, B. Suresh; Kumar, Senthil; Mohan Kumar, N. S.; Karunakaran, J. V.

    2015-01-01

    Anterior tooth fracture as a result of traumatic injuries, is frequently encountered in endodontic practice. Proper reconstruction of extensively damaged teeth can be achieved through the fragment reattachment procedure known as “biological restoration.” This case report refers to the esthetics and functional recovery of extensively damaged maxillary central incisor through the preparation and adhesive cementation of “biological post” in a young patient. Biological post obtained through extracted teeth from another individual–represent a low-cost option and alternative technique for the morphofunctional recovery of extensively damaged anterior teeth. PMID:26538952

  6. Co- and post-seismic slip associated with the Mw 7.7 2007 Tocopilla earthquake (North Chile): first results from InSAR and GPS data.

    NASA Astrophysics Data System (ADS)

    Béjar-Pizarro, M.; Carrizo, D.; Socquet, A.; Armijo, R.; de Chabalier, J. B.; Nercessian, A.; Charade, A.; Ruegg, J. C.; Barrientos, S.; Campos, J.

    2009-04-01

    The November 2007 Tocopilla (Mw 7.7) earthquake occurred in the seismic gap of North Chile, a region where there has been no major thrust event in the last 130 years. A network of continuous GPS stations operated by IPGP, Caltech, DGF and IRD measured the coseismic displacement associated with this earthquake, as well as the subsequent post seismic deformation. By combining the cGPS data with co-seismic interferograms we could retrieve the geometry and slip distribution of the rupture on the subduction interface. The earthquake initiated in the vicinity of Tocopilla city and vanished ~150km south, below the Mejillones Peninsula, a geomorphic singularity that appears to act as a barrier arresting large earthquakes (1877, 1995 and 2007 events). Tocopilla earthquake broke the deep part of the seismogenic zone down to the transition zone (35-50 km depth) and did not reach the surface. The slip distribution is characterized by two main slip asperities occurring 30 km apart, consistent with the first results from seismology (Peyrat et al., 2008, Delouis et al. 2008). We also study the early postseimic deformation using our GPS displacements collected during the months following the main shock and Envisat ASAR interferograms spanning the same period. Our preliminary results show that most of the postseismic slip occurred within the first 10 days after the main shock, and was mostly concentrated at the southern end of the rupture. We attempt to answer the next questions in relation to the postseismic deformation: Where was the postseismic slip located with respect to the coseismic slip? Can we distinguish different mechanisms of post-seismic deformation following the Tocopilla earthquake (afterslip, viscoelastic relaxation)? If yes, where (near field, far field) and when (temporal and spatial evolution of each mechanism)? What amount of afterslip experienced the subduction interface after the earthquake? How much does it represent compared to the seismic moment released by

  7. Post-Irradiation Bladder Syndrome After Radiotherapy of Malignant Neoplasm of Small Pelvis Organs: An Observational, Non-Interventional Clinical Study Assessing VESIcare®/Solifenacin Treatment Results

    PubMed Central

    Jaszczyński, Janusz; Kojs, Zbigniew; Stelmach, Andrzej; Wohadło, Łukasz; Łuczyńska, Elżbieta; Heinze, Sylwia; Rys, Janusz; Jakubowicz, Jerzy; Chłosta, Piotr

    2016-01-01

    Background Radiotherapy is explicitly indicated as one of the excluding factors in diagnosing overactive bladder syndrome (OAB). Nevertheless, symptoms of OAB such as urgent episodes, incontinence, pollakiuria, and nocturia, which are consequences of irradiation, led us to test the effectiveness of VESIcare®/Solifenacin in patients demonstrating these symptoms after radiation therapy of small pelvis organs due to malignant neoplasm. Material/Methods We conducted an observatory clinical study including 300 consecutive patients with symptoms of post-irradiation bladder; 271 of those patients completed the study. The observation time was 6 months and consisted of 3 consecutive visits taking place at 12-week intervals. We used VESIcare® at a dose of 5 mg a day. Every sixth patient was examined urodynamically at the beginning and at the end of the observation period, with an inflow speed of 50 ml/s. Results We noticed improvement and decline in the average number of episodes a day in the following parameters: number of micturitions a day (−36%, P<0.01), nocturia (−50%, P<0.01), urgent episodes (−41%, P<0.03), and episodes of incontinence (−43%, P<0.01). The patients’ quality of life improved. The average maximal cystometric volume increased by 34 ml (21%, p<0.01), average bladder volume of “first desire” increased by 42 ml (49%, P<0.01), and average detrusor muscle pressure at maximal cystometric volume diminished by 9 cmH2O (−36%, P<0.03). Conclusions The substance is well-tolerated. Solifenacin administered long-term to patients with symptoms of OAB after radiotherapy of a malignant neoplasm of the small pelvis organs has a daily impact in decreasing number of urgent episodes, incontinence, pollakiuria, and nocturia. PMID:27474270

  8. WIN OVER study: Efficacy and safety of olmesartan in Indian hypertensive patients: Results of an open label, non-comparative, multi-centric, post marketing observational study

    PubMed Central

    Kumbla, D.K.; Kumar, S.; Reddy, Y.V.; Trailokya, A.; Naik, M.

    2014-01-01

    Background Hypertension is a global health problem. Multiple classes of drugs including angiotensin receptor blockers (ARBs) are available for the treatment of hypertension. Olmesartan is a relatively newer ARB used in hypertension management. Objective To assess the efficacy and safety of WIN-BP (Olmesartan 20 mg/40 mg) tablet in Indian patients with hypertension. Material and methods An open label, non-comparative, multi-centric, real world post marketing observational study included Indian adult hypertensive patients who were treated with olmesartan 20 mg/40 mg tablet once daily for six months. The primary outcome was reduction of systolic blood pressure (SBP) to <140 mmHg and diastolic BP (DBP) to <90 mmHg at 3 and 6 months after initiation of treatment with olmesartan. All reported adverse events were recorded. Results A total of 8940 patients were enrolled in this study. Baseline SBP of 164 mmHg was reduced to 153, 145, 134 and 130 mmHg at the end of 15 days, 1, 3 and 6 months respectively. Similarly, baseline DBP of 100 mmHg was reduced to 93, 89, 84 and 82 mmHg at the end of 15 days, 1, 3 and 6 months respectively. The reduction in both systolic and diastolic blood pressure from day 15 to month 6 was statistically significant (p < 0.0001) with olmesartan treatment. The percentage of responders for both systolic and diastolic blood pressure increased consistently from day 15 to month 6. Only 0.08% patients reported the adverse events. No serious adverse event was reported in the study. Conclusion Olmesartan 20 mg/40 mg is effective and well tolerated without any serious adverse events in patients with hypertension. PMID:24973841

  9. Effects of a Pilates exercise program on muscle strength, postural control and body composition: results from a pilot study in a group of post-menopausal women.

    PubMed

    Bergamin, M; Gobbo, S; Bullo, V; Zanotto, T; Vendramin, B; Duregon, F; Cugusi, L; Camozzi, V; Zaccaria, M; Neunhaeuserer, D; Ermolao, A

    2015-12-01

    Participation in exercise programs is heartily recommended for older adults since the level of physical fitness directly influences functional independence. The aim of this present study was to investigate the effects of supervised Pilates exercise training on the physical function, hypothesizing that a period of Pilates exercise training (PET) can increase overall muscle strength, body composition, and balance, during single and dual-task conditions, in a group of post-menopausal women. Twenty-five subjects, aged 59 to 66 years old, were recruited. Eligible participants were assessed prior and after 3 months of PET performed twice per week. Muscular strength was evaluated with handgrip strength (HGS) test, 30-s chair sit-to-stand test (30CST), and abdominal strength (AST) test. Postural control and dual-task performance were measured through a stabilometric platform while dynamic balance with 8 ft up and go test. Finally, body composition was assessed by means of dual-energy X-ray absorptiometry. Statistically significant improvements were detected on HGS (+8.22%), 30CST (+23.41%), 8 ft up and go test (-5.95%), AST (+30.81%), medio-lateral oscillations in open eyes and dual-task condition (-22.03% and -10.37%). Pilates was effective in increasing upper body, lower body, and abdominal muscle strength. No changes on body composition were detected. Results on this investigation indicated also that 12-week of mat Pilates is not sufficient to determine a clinical meaningful improvement on static balance in single and dual-task conditions. PMID:26578458

  10. Effects of a Pilates exercise program on muscle strength, postural control and body composition: results from a pilot study in a group of post-menopausal women.

    PubMed

    Bergamin, M; Gobbo, S; Bullo, V; Zanotto, T; Vendramin, B; Duregon, F; Cugusi, L; Camozzi, V; Zaccaria, M; Neunhaeuserer, D; Ermolao, A

    2015-12-01

    Participation in exercise programs is heartily recommended for older adults since the level of physical fitness directly influences functional independence. The aim of this present study was to investigate the effects of supervised Pilates exercise training on the physical function, hypothesizing that a period of Pilates exercise training (PET) can increase overall muscle strength, body composition, and balance, during single and dual-task conditions, in a group of post-menopausal women. Twenty-five subjects, aged 59 to 66 years old, were recruited. Eligible participants were assessed prior and after 3 months of PET performed twice per week. Muscular strength was evaluated with handgrip strength (HGS) test, 30-s chair sit-to-stand test (30CST), and abdominal strength (AST) test. Postural control and dual-task performance were measured through a stabilometric platform while dynamic balance with 8 ft up and go test. Finally, body composition was assessed by means of dual-energy X-ray absorptiometry. Statistically significant improvements were detected on HGS (+8.22%), 30CST (+23.41%), 8 ft up and go test (-5.95%), AST (+30.81%), medio-lateral oscillations in open eyes and dual-task condition (-22.03% and -10.37%). Pilates was effective in increasing upper body, lower body, and abdominal muscle strength. No changes on body composition were detected. Results on this investigation indicated also that 12-week of mat Pilates is not sufficient to determine a clinical meaningful improvement on static balance in single and dual-task conditions.

  11. The Fantastic and the Real

    ERIC Educational Resources Information Center

    McLester, Susan

    2005-01-01

    The National Engineers Week Future City Competition provides compelling evidence of the power of pairing computer software and technology with traditional hands-on activities to teach challenging subject matter and also harder- to- measure "real" workplace skills. Now in its 13th year, the Competition asks middle school students to work in teams…

  12. Sediment pore-water toxicity test results and preliminary toxicity identification of post-landfall pore-water samples collected following the Deepwater Horizon oil release, Gulf of Mexico, 2010

    USGS Publications Warehouse

    Biedenbach, James M.; Carr, Robert S.

    2011-01-01

    Pore water from coastal beach and marsh sediments from the northern Gulf of Mexico, pre- and post-landfall of the Deepwater Horizon oil release, were collected and evaluated for toxicity with the sea urchin fertilization and embryological development assays. There were 17 pre-landfall samples and 49 post-landfall samples tested using both assays. Toxicity was determined in four pre-landfall sites and in seven post-landfall sites in one or both assays as compared to a known reference sediment pore-water sample collected in Aransas Bay, Texas. Further analysis and testing of five of the post-landfall toxic samples utilizing Toxicity Identification Evaluation techniques indicated that ammonia, and to a lesser extent metals, contributed to most, if not all, of the observed toxicity in four of the five samples. Results of one sample (MS-39) indicated evidence that ammonia, metals, and non-ionic organics were contributing to the observed toxicity.

  13. Habitat selection and adult-recruit interactions in Pectinaria koreni (Malmgren) (Annelida: Polychaeta) post-larval populations: Results of flume experiments

    NASA Astrophysics Data System (ADS)

    Olivier, Frédéric; Desroy, Nicolas; Retière, Christian

    1996-12-01

    The fate of recently settled populations of soft-bottom invertebrates depends not only on dispersal of pelagic larvae by tidal currents but also on other physical ( e. g. resuspension) and biological mechanisms ( e.g. habitat selection and adult-recruit interactions) acting at the water-substratum interface. To assess the relative importance of such processes under megatidal conditions in the Abra alba community of the eastern Baie de Seine (English Channel), flume experiments were conducted on post-larvae of the dominant polychaete species, Pectinaria koreni. Habitat selection by post-larvae of P. koreni was determined in a first set of experiments, where individuals were sowed either on a suitable or on an unsuitable substratum. Once resuspended, post-larvae were given a choice between two highly contrasting treatments with a natural organic-rich muddy sand and a bare flat PVC surface. P. koreni post-larvae were able to leave an unfavourable substratum into which they had initially burrowed and reach a more suitable substrate by drifting (induced by the secretion of mucus) before final settlement. The influence of adults on habitat selection and survival of P. koreni post-larvae was analysed in a second set of experiments, where individuals were sowed onto a suitable sediment with adults (test treatment) or without (control treatment). The presence of conspecific adults induced a high resuspension rate of the post-larvae. Drifting occurred mainly just after the introduction of the current and affected the whole experimental population, regardless of size. Such a response seems to be related to the intense bioturbation caused by the sub-surface deposit-feeding habit of the adults, which alters the boundary-layer flow. In contrast, the presence of adults of Owenia fusiformis, another dominant polychaete of the Abra alba community, led to an enhanced recruitment by a reduction in post-larvae resuspension. In fact, at low shear velocities, dense aggregates of tubes

  14. The association between component malalignment and post-operative pain following navigation-assisted total knee arthroplasty: results of a cohort/nested case-control study.

    PubMed

    Czurda, Thomas; Fennema, Peter; Baumgartner, Martin; Ritschl, Peter

    2010-07-01

    Previous studies have noted an adverse relationship between implant malalignment during total knee arthroplasty (TKA) and post-operative pain. Although some evidence exists indicating that computer-assisted surgical navigation for TKA can improve the accuracy of component alignment, its impact on clinical outcomes is currently unknown. The dual goals of the present cohort/nested case-control study were to (1) compare self-reported responses to the Western Ontario-McMaster Osteoarthritis Index (WOMAC) questionnaire between computer-assisted TKA (123 patients) using the imageless PiGalileo navigation system and conventional TKA (207 patients) [cohort analysis], and (2) to investigate a potential association between malalignment and post-operative pain in 19 painful knees and 19 asymptomatic knees obtained from the cohort analysis using matched sampling [nested case-control study]. In the cohort analysis, a relevant but non-significant (P = 0.06) difference in the occurrence of chronic pain was observed between the navigated (12%) and conventional arms (20%). Median post-operative WOMAC pain score was 100 (range, 50-100) in the conventional group and 100 (range, 65-100) in the navigated group. However, the Mann-Whitney test revealed a significant difference in favor of the navigated group (P = 0.01). In the nested case-control analysis, radiological outcomes and computer tomography (CT) measurements of femoral rotation were compared between the groups. The CT rotation measurements yielded evidence of a relationship between post-operative pain and incorrect rotational alignment of the femoral component of more than 3 degrees (OR: 7; 95% CI: 1.2-42; P = .033). In conclusion, there was no clinical benefit to computer-assisted navigation; however, a statistically significant relationship was observed between incorrect rotational alignment of the femoral component and symptoms of post-operative pain following TKA.

  15. Differences in residents’ self-reported confidence and case experience between two post-graduate rotation curricula: results of a nationwide survey in Japan

    PubMed Central

    2014-01-01

    Background In Japan, all trainee physicians must begin clinical practice in a standardized, mandatory junior residency program, which encompasses the first two years of post-graduate medical training (PGY1 – PGY2). Implemented in 2004 to foster primary care skills, the comprehensive rotation program (CRP) requires junior residents to spend 14 months rotating through a comprehensive array of clinical departments including internal medicine, surgery, anesthesiology, obstetrics-gynecology (OBGYN), pediatrics, psychiatry, and rural medicine. In 2010, Japan’s health ministry relaxed this curricular requirement, allowing training programs to offer a limited rotation program (LRP), in which core departments constitute 10 months of training, with electives geared towards residents’ choice of career specialty comprising the remaining 14 months. The effectiveness of primary care skill acquisition during early training warrants evaluation. This study assesses self-reported confidence with clinical competencies, as well as case experience, between residents in CRP versus LRP curricula. Methods A nation-wide cross-sectional study of all PGY2 physicians in Japan was conducted in March 2011. Primary outcomes were self-report confidence for 98 clinical competency items, and number of cases experienced for 85 common diseases. We compared confidence scores and case experience between residents in CRP and LRP programs, adjusting for parameters relevant to training. Results Among 7506 PGY2 residents, 5052 replied to the survey (67.3%). Of 98 clinical competency items, CRP residents reported higher confidence in 12 items compared to those in an LRP curriculum, 10 of which remained significantly higher after adjustment. CRP trainees reported lower confidence scores in none of the items. Out of 85 diseases, LRP residents reported less experience with 11 diseases. CRP trainees reported lower case experience with one disease, though this did not remain significant on adjusted

  16. Active rehabilitation for chronic low back pain: Cognitive-behavioral, physical, or both? First direct post-treatment results from a randomized controlled trial [ISRCTN22714229

    PubMed Central

    Smeets, Rob JEM; Vlaeyen, Johan WS; Hidding, Alita; Kester, Arnold DM; van der Heijden, Geert JMG; van Geel, Antonia CM; Knottnerus, J André

    2006-01-01

    Background The treatment of non-specific chronic low back pain is often based on three different models regarding the development and maintenance of pain and especially functional limitations: the deconditioning model, the cognitive behavioral model and the biopsychosocial model. There is evidence that rehabilitation of patients with chronic low back pain is more effective than no treatment, but information is lacking about the differential effectiveness of different kinds of rehabilitation. A direct comparison of a physical, a cognitive-behavioral treatment and a combination of both has never been carried out so far. Methods The effectiveness of active physical, cognitive-behavioral and combined treatment for chronic non-specific low back pain compared with a waiting list control group was determined by performing a randomized controlled trial in three rehabilitation centers. Two hundred and twenty three patients were randomized, using concealed block randomization to one of the following treatments, which they attended three times a week for 10 weeks: Active Physical Treatment (APT), Cognitive-Behavioral Treatment (CBT), Combined Treatment of APT and CBT (CT), or Waiting List (WL). The outcome variables were self-reported functional limitations, patient's main complaints, pain, mood, self-rated treatment effectiveness, treatment satisfaction and physical performance including walking, standing up, reaching forward, stair climbing and lifting. Assessments were carried out by blinded research assistants at baseline and immediately post-treatment. The data were analyzed using the intention-to-treat principle. Results For 212 patients, data were available for analysis. After treatment, significant reductions were observed in functional limitations, patient's main complaints and pain intensity for all three active treatments compared to the WL. Also, the self-rated treatment effectiveness and satisfaction appeared to be higher in the three active treatments. Several

  17. Ex vivo adenoviral vector gene delivery results in decreased vector-associated inflammation pre- and post-lung transplantation in the pig.

    PubMed

    Yeung, Jonathan C; Wagnetz, Dirk; Cypel, Marcelo; Rubacha, Matthew; Koike, Terumoto; Chun, Yi-Min; Hu, Jim; Waddell, Thomas K; Hwang, David M; Liu, Mingyao; Keshavjee, Shaf

    2012-06-01

    Acellular normothermic ex vivo lung perfusion (EVLP) is a novel method of donor lung preservation for transplantation. As cellular metabolism is preserved during perfusion, it represents a potential platform for effective gene transduction in donor lungs. We hypothesized that vector-associated inflammation would be reduced during ex vivo delivery due to isolation from the host immune system response. We compared ex vivo with in vivo intratracheal delivery of an E1-, E3-deleted adenoviral vector encoding either green fluorescent protein (GFP) or interleukin-10 (IL-10) to porcine lungs. Twelve hours after delivery, the lung was transplanted and the post-transplant function assessed. We identified significant transgene expression by 12 hours in both in vivo and ex vivo delivered groups. Lung function remained excellent in all ex vivo groups after viral vector delivery; however, as expected, lung function decreased in the in vivo delivered adenovirus vector encoding GFP (AdGFP) group with corresponding increases in IL-1β levels. Transplanted lung function was excellent in the ex vivo transduced lungs and inferior lung function was seen in the in vivo group after transplantation. In summary, ex vivo delivery of adenoviral gene therapy to the donor lung is superior to in vivo delivery in that it leads to less vector-associated inflammation and provides superior post-transplant lung function. PMID:22453765

  18. Independent post-zygotic breaks of a dicentric chromosome result in mosaicism for an inverted duplication deletion 9p and terminal deletion 9p.

    PubMed

    Schlade-Bartusiak, Kamilla; Tucker, Tracy; Safavi, Holly; Livingston, Janet; van Allen, Margot I; Eydoux, Patrice; Armstrong, Linlea

    2013-05-01

    Mosaicism with two cell lines having different rearrangements of the same chromosome is rare. Only a few cases of mosaicism have been described in association with chromosomal inverted duplication deletion (inv dup del) rearrangements. A well-established mechanism of formation of inv dup del rearrangements involves a dicentric intermediate, which undergoes breakage during cell division, generating cells with either an inv dup del or a simple deletion. A patient with developmental delay and dysmorphic features was found to carry two cell lines with rearrangements of 9p: an inv dup del 9p and a terminal deletion 9p. Microarray and FISH analysis showed that these cell lines do not constitute the reciprocal products of a single dicentric breakage event. We propose that independent post-zygotic breaks of a dicentric chromosome as a likely mechanism leading to the generation of the observed cell lines. The post-zygotic origin of the inv dup del rearrangements and the associated mosaicism can be a more frequent phenomenon than currently appreciated. Therefore, genotype-phenotype correlations in the inv dup del rearrangements need to take into account the possible presence of other abnormal cell lines during early development.

  19. Association between age at menarche and diabetes in Korean post-menopausal women: results from the Korea National Health and Nutrition Examination Survey (2007-2009).

    PubMed

    Hwang, Eunjung; Lee, Kyong Won; Cho, Yoonsu; Chung, Hye Kyung; Shin, Min-Jeong

    2015-01-01

    Early menarche is known to be associated with diabetes, however this association remains controversial. Our study aimed to investigate the possible association between age at menarche and diabetes prevalence in post-menopausal Korean women. This study included 3,254 post-menopausal Korean women aged 50-85 years from the Korea National Health and Nutrition Examination Survey IV (KNHANES 2007-2009). Logistic regression analyses were used to estimate odds ratios (ORs) for diabetes prevalence. Levels of biochemical markers were compared according to groups by age at menarche. Women in the earlier menarche age group (10-12 years) showed higher levels of fasting blood glucose (FBG) and scores of homeostatic model assessment in the insulin resistance (HOMA-IR) index than other groups (p <0.05). After adjusting for potential confounding factors, early age at menarche was significantly associated with a higher prevalence of diabetes (OR 1.86, 95% confidence intervals [CI] 1.07-3.23). The observed association remained significant despite additional adjustment for body mass index and waist circumference (OR 1.82, 95% CI 1.03-3.23) and despite further adjustments for FBG levels and HOMA-IR index (OR 2.25, 95% CI 1.11-4.55). Our findings strengthen the hypothesis that younger age at menarche is associated with increased diabetes prevalence in the Korean population.

  20. Enhanced early sensory outcome after nerve repair as a result of immediate post-operative re-learning: a randomized controlled trial.

    PubMed

    Rosén, B; Vikström, P; Turner, S; McGrouther, D A; Selles, R W; Schreuders, T A R; Björkman, A

    2015-07-01

    We assessed the use of guided plasticity training to improve the outcome in the first 6 months after nerve repair. In a multicentre randomized controlled trial, 37 adults with median or ulnar nerve repair at the distal forearm were randomized to intervention, starting the first week after surgery with sensory and motor re-learning using mirror visual feedback and observation of touch, or to a control group with re-learning starting when reinnervation could be detected. The primary outcome at 3 and 6 months post-operatively was discriminative touch (shape texture identification test, part of the Rosen score). At 6 months, discriminative touch was significantly better in the early intervention group. Improvement of discriminative touch between 3 and 6 months was also significantly greater in that group. There were no significant differences in motor function, pain or in the total score. We conclude that early re-learning using guided plasticity may have a potential to improve the outcomes after nerve repair. LEVEL OF EVIDENCE II. PMID:25294735

  1. Traditional games resulted in post-exercise hypotension and a lower cardiovascular response to the cold pressor test in healthy children.

    PubMed

    Rauber, Suliane B; Boullosa, Daniel A; Carvalho, Ferdinando O; de Moraes, José F V N; de Sousa, Ioranny R C; Simões, Herbert G; Campbell, Carmen S G

    2014-01-01

    The present study aimed to verify if blood pressure (BP) reactivity could be reduced through a previous single session of active playing when compared to sedentary leisure. Sixteen pre-pubertal healthy children participated in this study. After familiarization with procedures and anthropometric evaluation, participants performed three sessions in randomized order: (1) 30 min of traditional Brazilian games (PLAY); (2) 30 min of video game playing (DDR); and (3) 30 min of watching TV (TV). Each session lasted 80 min, being 10 min of rest; 30 min of intervention activity; and 40 min of recovery. After recovery, the Cold Pressor Test (CPT) was used for the assessment of acute cardiovascular reactivity. BP was recorded at 30 s and 1 min during the CPT. Analysis of variance showed post-exercise hypotension (PEH) only after PLAY, and that systolic and diastolic BP were significantly increased in all conditions during CPT. However, the magnitude of the CPT-induced BP response was significantly less in PLAY compared to DDR and TV. The PEH observed during recovery and the reduced BP response to CPT following playing traditional games may be due its higher cardiovascular and metabolic demand as was indicated by the increased heart rate, oxygen consumption, and BP. It was concluded that BP reactivity to stress may be reduced through a previous single session of traditional games and that PEH was recorded only after this exercise form. This benefit indicates a potential role of playing strategies for cardiovascular health in childhood. PMID:25009506

  2. Post-operative depletion of platelet count is associated with anastomotic insufficiency following intrahepatic cholangiojejunostomy: a case–control study from the results of 220 cases of intrahepatic cholangiojejunostomy

    PubMed Central

    2014-01-01

    Background Post-operative anastomotic insufficiency following major hepato-biliary surgery has significant impacts on the post-operative course. Recent reports have revealed that platelets play an important role in liver regeneration and wound healing. From these experimental and clinical results on platelet function, we hypothesized that post-operative platelet depletion (to <10 × 104/μL) would be associated with delayed liver regeneration as well as anastomotic insufficiency of intrahepatic cholangiojejunostomy. However, little information is available regarding correlations between platelet count and these complications. The purposes of the present study were, firstly, to evaluate the incidence of anastomotic insufficiency following intrahepatic cholangiojejunostomy and, secondly, to evaluate whether platelet depletion represents a risk factor for anastomotic insufficiency in intrahepatic cholangiojejunostomy. Methods Participants in this study comprised 220 consecutive patients who underwent intrahepatic cholangiojejunostomy following hepato-biliary resection for biliary malignancies between September 1998 and December 2010. Anastomotic insufficiency was confirmed by cholangiographic demonstration of leakage from the anastomosis using contrast medium introduced via a biliary drainage tube or prophylactic drain placed during surgery. Results Anastomotic insufficiency of the intrahepatic cholangiojejunostomy occurred in 13 of 220 patients (6%). Thirteen of the 220 patients, including one with anastomotic insufficiency, died during the study. Uni- and multivariate analyses both revealed that platelet depletion on post-operative day 1 (<10 × 104/μL) correlated with anastomotic insufficiency. Conclusion Post-operative platelet depletion was closely associated with anastomotic insufficiency following intrahepatic cholangiojejunostomy. This correlation has been established, but the underlying mechanisms have not. PMID:25323783

  3. Results of Arthroscopic Bankart Lesion Repair in Patients with Post-Traumatic Anterior Instability of the Shoulder and a Non-Engaging Hill-Sachs Lesion with a Suture Anchor after a Minimum of 6-Year Follow-Up

    PubMed Central

    Szyluk, Karol; Jasiński, Andrzej; Widuchowski, Wojciech; Mielnik, Michał; Koczy, Bogdan

    2015-01-01

    Background Shoulder instability is an important clinical problem. Arthroscopic surgery is an established treatment modality in shoulder instability, but it continues to be associated with a high rate of recurrences and complications. The purpose of the study was to analyze late outcomes of arthroscopic repair of Bankart lesions in patients with post-traumatic anterior shoulder instability and non-engaging Hill-Sachs lesion, with special focus on the incidence and causes of recurrences and complications. Material/Methods We investigated 92 patients (92 shoulders) who underwent surgery on account of post-traumatic anterior shoulder instability. The duration of follow-up ranged from 6 to 12.5 years (mean: 8.2 years). All patients were operated on in the lateral decubitus position using FASTak 2.8-mm suture anchors (FASTak, Arthrex, Naples, Florida). Treatment outcomes were evaluated using the Rowe and University of California at Los Angeles rating system (UCLA). Results According to Rowe scores, there were 71 (81.5%) excellent, 12 (12.6%) good, 5 (5.3%) satisfactory, and 2 (2.1%) poor results. Rowe scores improved in a statistically significant manner (p=0.00) post-surgery, to a mean of 90 (range: 25–100). Treatment outcomes measured as UCLA scores improved in a statistically significant manner (p=0.00), reaching post-operative levels of 12–35 (mean: 33.5). There were 9 recurrences, 1 case of axillary nerve praxia, and 1 case of anchor loosening. Conclusions With rigorous criteria for qualifying patients for surgery, arthroscopic treatment of post-traumatic anterior shoulder instability produces good outcomes and low recurrence and complication rates irrespective of the number of previous dislocations, age, or sex. PMID:26256225

  4. Meso- and microscale structures related to post-magmatic deformation of the outer Izu-Bonin-Mariana fore arc system: preliminary results from IODP Expedition 352

    NASA Astrophysics Data System (ADS)

    Micheuz, P.; Kurz, W.; Ferre, E. C.

    2015-12-01

    IODP Expedition 352 aimed to drill through the entire volcanic sequence of the Bonin fore arc. Four sites were drilled, two on the outer fore arc and two on the upper trench slope. Analysis of structures within drill cores, combined with borehole and site survey seismic data, indicates that tectonic deformation in the outer Izu-Bonin-Mariana fore arc is mainly post-magmatic, associated with the development of syn-tectonic sedimentary basins. Within the magmatic basement, deformation was accommodated by shear along cataclastic fault zones, and the formation of tension fractures, hybrid (tension and shear) fractures, and shear fractures. Veins commonly form by mineral filling of tension or hybrid fractures and, generally, show no or limited observable macroscale displacement along the fracture plane. The vein filling generally consists of (Low Mg-) calcite and/or various types of zeolite as well as clay. Vein frequency varies with depth but does not seem to correlate with the proximity of faults. This may indicate that these veins are genetically related to hydrothermal activity taking place shortly after magma cooling. Host-rock fragments are commonly embedded within precipitated vein material pointing to a high fluid pressure. Vein thickness varies from < 1 mm up to 15 mm. The wider veins appear to have formed in incremental steps of extension. Calcite veins tend to be purely dilational at shallow depths, but gradually evolve towards oblique tensional veins at depth, as shown by the growth of stretched calcite and/or zeolites (idiomorphic and/or stretched) with respect to vein margins. With increasing depth, the calcite grains exhibit deformation microstructures more frequently than at shallower core intervals. These microstructures include thin twinning (type I twins), increasing in width with depth (type I and type II twins), curved twins, and subgrain boundaries indicative of incipient plastic deformation.

  5. Coseismic and Early Post-Seismic Slip Distributions of the 2012 Emilia (Northern Italy) Seismic Sequence: New Insights in the Faults Activation and Resulting Stress Changes on Adjacent Faults

    NASA Astrophysics Data System (ADS)

    Cheloni, D.; Giuliani, R.; D'Agostino, N.; Mattone, M.; Bonano, M.; Fornaro, G.; Lanari, R.; Reale, D.

    2015-12-01

    The 2012 Emilia sequence (main shocks Mw 6.1 May 20 and Mw 5.9 May 29) ruptured two thrust segments of a ~E-W trending fault system of the buried Ferrara Arc, along a portion of the compressional system of the Apennines that had remained silent during past centuries. Here we use the rupture geometry constrained by the aftershocks and new geodetic data (levelling, InSAR and GPS measurements) to estimate an improved coseismic slip distribution of the two main events. In addition, we use post-seismic displacements, described and analyzed here for the first time, to infer a brand new post-seismic slip distribution of the May 29 event in terms of afterslip on the same coseismic plane. In particular, in this study we use a catalog of precisely relocated aftershocks to explore the different proposed geometries of the proposed thrust segments that have been published so far and estimate the coseismic and post-seismic slip distributions of the ruptured planes responsible for the two main seismic events from a joint inversion of the geodetic data.Joint inversion results revealed that the two earthquakes ruptured two distinct planar thrust faults, characterized by single main coseismic patches located around the centre of the rupture planes, in agreement with the seismological and geological information pointing out the Ferrara and the Mirandola thrust faults, as the causative structures of the May 20 and May 29 main shocks respectively.The preferred post-seismic slip distribution related to the 29 May event, yielded to a main patch of afterslip (equivalent to a Mw 5.6 event) located westward and up-dip of the main coseismic patch, suggesting that afterslip was triggered at the edges of the coseismic asperity. We then use these co- and post-seismic slip distribution models to calculate the stress changes on adjacent fault.

  6. Results availability for analgesic device, complex regional pain syndrome, and post-stroke pain trials: comparing the RReADS, RReACT, and RReMiT databases.

    PubMed

    Dufka, Faustine L; Munch, Troels; Dworkin, Robert H; Rowbotham, Michael C

    2015-01-01

    Evidence-based medicine rests on the assumption that treatment recommendations are robust, free from bias, and include results of all randomized clinical trials. The Repository of Registered Analgesic Clinical Trials search and analysis methodology was applied to create databases of complex regional pain syndrome (CRPS) and central post-stroke pain (CPSP) trials and adapted to create the Repository of Registered Analgesic Device Studies databases for trials of spinal cord stimulation (SCS), repetitive transcranial magnetic stimulation (rTMS), and transcranial direct current stimulation (tDCS). We identified 34 CRPS trials, 18 CPSP trials, 72 trials of SCS, and 92 trials of rTMS/tDCS. Irrespective of time since study completion, 45% of eligible CRPS and CPSP trials and 46% of eligible SCS and rTMS/tDCS trials had available results (peer-reviewed literature, results entered on registry, or gray literature); peer-reviewed publications could be found for 38% and 39%, respectively. Examining almost 1000 trials across a spectrum of painful disorders (fibromyalgia, diabetic painful neuropathy, post-herpetic neuralgia, migraine, CRPS, CPSP) and types of treatment, no single study characteristic consistently predicts unavailability of results. Results availability is higher 12 months after study completion but remains below 60% for peer-reviewed publications. Recommendations to increase results availability include supporting organizations advocating for transparency, enforcing existing results reporting regulations, enabling all primary registries to post results, stating trial registration numbers in all publication abstracts, and reducing barriers to publishing "negative" trials. For all diseases and treatment modalities, evidence-based medicine must rigorously adjust for the sheer magnitude of missing results in formulating treatment recommendations.

  7. Results availability for analgesic device, complex regional pain syndrome, and post-stroke pain trials: comparing the RReADS, RReACT, and RReMiT databases

    PubMed Central

    Dufka, Faustine L.; Munch, Troels; Dworkin, Robert H.; Rowbotham, Michael C.

    2015-01-01

    Abstract Evidence-based medicine rests on the assumption that treatment recommendations are robust, free from bias, and include results of all randomized clinical trials. The Repository of Registered Analgesic Clinical Trials search and analysis methodology was applied to create databases of complex regional pain syndrome (CRPS) and central post-stroke pain (CPSP) trials and adapted to create the Repository of Registered Analgesic Device Studies databases for trials of spinal cord stimulation (SCS), repetitive transcranial magnetic stimulation (rTMS), and transcranial direct current stimulation (tDCS). We identified 34 CRPS trials, 18 CPSP trials, 72 trials of SCS, and 92 trials of rTMS/tDCS. Irrespective of time since study completion, 45% of eligible CRPS and CPSP trials and 46% of eligible SCS and rTMS/tDCS trials had available results (peer-reviewed literature, results entered on registry, or gray literature); peer-reviewed publications could be found for 38% and 39%, respectively. Examining almost 1000 trials across a spectrum of painful disorders (fibromyalgia, diabetic painful neuropathy, post-herpetic neuralgia, migraine, CRPS, CPSP) and types of treatment, no single study characteristic consistently predicts unavailability of results. Results availability is higher 12 months after study completion but remains below 60% for peer-reviewed publications. Recommendations to increase results availability include supporting organizations advocating for transparency, enforcing existing results reporting regulations, enabling all primary registries to post results, stating trial registration numbers in all publication abstracts, and reducing barriers to publishing “negative” trials. For all diseases and treatment modalities, evidence-based medicine must rigorously adjust for the sheer magnitude of missing results in formulating treatment recommendations. PMID:25599303

  8. Strain balanced quantum posts

    SciTech Connect

    Alonso-Alvarez, D.; Alen, B.; Ripalda, J. M.; Llorens, J. M.; Taboada, A. G.; Briones, F.; Roldan, M. A.; Hernandez-Saz, J.; Hernandez-Maldonado, D.; Herrera, M.; Molina, S. I.

    2011-04-25

    Quantum posts are assembled by epitaxial growth of closely spaced quantum dot layers, modulating the composition of a semiconductor alloy, typically InGaAs. In contrast with most self-assembled nanostructures, the height of quantum posts can be controlled with nanometer precision, up to a maximum value limited by the accumulated stress due to the lattice mismatch. Here, we present a strain compensation technique based on the controlled incorporation of phosphorous, which substantially increases the maximum attainable quantum post height. The luminescence from the resulting nanostructures presents giant linear polarization anisotropy.

  9. Short Course of Post-Transplantation Cyclophosphamide and Bortezomib for Graft-versus-Host Disease Prevention after Allogeneic Peripheral Blood Stem Cell Transplantation Is Feasible and Yields Favorable Results: A Phase I Study.

    PubMed

    Al-Homsi, Ahmad-Samer; Cole, Kelli; Bogema, Marlee; Duffner, Ulrich; Williams, Stephanie; Mageed, Aly

    2015-07-01

    An effective graft-versus-host disease (GVHD) preventative approach that preserves the graft-versus-tumor effect after allogeneic hematopoietic stem cell transplantation (HSCT) remains elusive. Standard GVHD prophylactic regimens suppress T cells indiscriminately and are suboptimal. Conversely, post-transplantation high-dose cyclophosphamide selectively destroys proliferating alloreactive T cells, allows the expansion of regulatory T cells, and induces long-lasting clonal deletion of intrathymic antihost T cells. It has been successfully used to prevent GVHD after allogeneic HSCT. Bortezomib has antitumor activity on a variety of hematological malignancies and exhibits a number of favorable immunomodulatory effects that include inhibition of dendritic cells. Therefore, an approach that combines post-transplantation cyclophosphamide and bortezomib seems attractive. Herein, we report the results of a phase I study examining the feasibility and safety of high-dose post-transplantation cyclophosphamide in combination with bortezomib in patients undergoing allogeneic peripheral blood HSCT from matched siblings or unrelated donors after reduced-intensity conditioning. Cyclophosphamide was given at a fixed dose (50 mg/kg on days +3 and +4). Bortezomib dose was started at .7 mg/m2, escalated up to 1.3 mg/m2, and was administered on days 0 and +3. Patients receiving grafts from unrelated donors also received rabbit antithymocyte globulin. The combination was well tolerated and allowed prompt engraftment in all patients. The incidences of acute GVHD grades II to IV and grades III and IV were 20% and 6.7%, respectively. With a median follow-up of 9.1 months (range, 4.3 to 26.7), treatment-related mortality was 13.5% with predicted 2-year disease-free survival and overall survival of 55.7% and 68%, respectively. The study suggests that the combination of post-transplantation cyclophosphamide and bortezomib is feasible and may offer an effective and practical GVHD prophylactic

  10. Post-zygotic breakage of a dicentric chromosome results in mosaicism for a telocentric 9p marker chromosome in a boy with developmental delay.

    PubMed

    Pedurupillay, C R J; Misceo, D; Gamage, T H; Dissanayake, V H W; Frengen, E

    2014-01-01

    Chromosomal rearrangements resulting in an inverted duplication and a terminal deletion (inv dup del) can occur due to three known mechanisms, two of them resulting in a normal copy region between the duplicated regions. These mechanisms involve the formation of a dicentric chromosome, which undergo breakage during cell division resulting in cells with either an inverted duplication and deletion or a terminal deletion. We describe a mosaic 3 year old patient with two cell lines carrying a chromosome 9p deletion where one of the cell lines contains an additional telocentric marker chromosome. Our patient is mosaic for the product of a double breakage of a dicentric chromosome including a centric fission. Mosaicism involving different rearrangements of the same chromosome is rare and suggests an early mitotic breakage event. Chr9p terminal deletions associated with duplications have previously been reported in 11 patients. We compare the clinical features of all 12 patients including the patient that we report here. To the best to our knowledge this is a first case reported where the double breakage occurred in the dicentric derivative chromosome 9.

  11. Treatment Default amongst Patients with Tuberculosis in Urban Morocco: Predicting and Explaining Default and Post-Default Sputum Smear and Drug Susceptibility Results

    PubMed Central

    Ghali, Iraqi; Kizub, Darya; Billioux, Alexander C.; Bennani, Kenza; Bourkadi, Jamal Eddine; Benmamoun, Abderrahmane; Lahlou, Ouafae; Aouad, Rajae El; Dooley, Kelly E.

    2014-01-01

    Setting Public tuberculosis (TB) clinics in urban Morocco. Objective Explore risk factors for TB treatment default and develop a prediction tool. Assess consequences of default, specifically risk for transmission or development of drug resistance. Design Case-control study comparing patients who defaulted from TB treatment and patients who completed it using quantitative methods and open-ended questions. Results were interpreted in light of health professionals’ perspectives from a parallel study. A predictive model and simple tool to identify patients at high risk of default were developed. Sputum from cases with pulmonary TB was collected for smear and drug susceptibility testing. Results 91 cases and 186 controls enrolled. Independent risk factors for default included current smoking, retreatment, work interference with adherence, daily directly observed therapy, side effects, quick symptom resolution, and not knowing one’s treatment duration. Age >50 years, never smoking, and having friends who knew one’s diagnosis were protective. A simple scoring tool incorporating these factors was 82.4% sensitive and 87.6% specific for predicting default in this population. Clinicians and patients described additional contributors to default and suggested locally-relevant intervention targets. Among 89 cases with pulmonary TB, 71% had sputum that was smear positive for TB. Drug resistance was rare. Conclusion The causes of default from TB treatment were explored through synthesis of qualitative and quantitative data from patients and health professionals. A scoring tool with high sensitivity and specificity to predict default was developed. Prospective evaluation of this tool coupled with targeted interventions based on our findings is warranted. Of note, the risk of TB transmission from patients who default treatment to others is likely to be high. The commonly-feared risk of drug resistance, though, may be low; a larger study is required to confirm these findings

  12. Pressure measurements in the spinal canal of post-mortem human subjects during rear-end impact and correlation of results to the neck injury criterion.

    PubMed

    Eichberger, A; Darok, M; Steffan, H; Leinzinger, P E; Boström, O; Svensson, M Y

    2000-03-01

    The aim of this study is to validate the pressure effect theory on human beings during a realistic rear-end impact and to correlate the neck injury criterion to pressure in the spinal canal. Sled experiments were performed using a test setup similar to real rear-end collisions. Test conditions were chosen based on accident statistics and recordings of real accidents. In particular, velocity change and acceleration level were reproduced similar to actual collisions. The head restraint as well as the seat back were adjusted to different positions. Two small pressure transducer were implemented to the spinal canal of postmortem human subjects and pressure measurement similar to the pig experiments (using exactly the same equipment) were performed. A total set of 21 experiments with four different subjects were performed. The subjects were additionally instrumented with triaxial accelerometers that allowed for calculation of the NIC criterion. Results showed that NIC and pressure amplitudes of the CSF correlate well and therefore NIC seems to be able to predict these amplitudes also for human beings. Conclusions whether these pressure effects induce soft tissue neck injuries or not could not be drawn and should be investigated in further research.

  13. POST-PERIASTRON GAMMA-RAY FLARE FROM PSR B1259-63/LS 2883 AS A RESULT OF COMPTONIZATION OF THE COLD PULSAR WIND

    SciTech Connect

    Khangulyan, Dmitry; Bogovalov, Sergey V.; Ribo, Marc E-mail: felix.aharonian@dias.ie E-mail: mribo@am.ub.es

    2012-06-10

    We argue that the bright flare of the binary pulsar PSR B1259-63/LS2883 detected by the Fermi Large Area Telescope is due to the inverse Compton scattering of the unshocked electron-positron pulsar wind with a Lorentz factor {Gamma}{sub 0} Almost-Equal-To 10{sup 4}. The combination of two effects both linked to the circumstellar disk (CD) is a key element in the proposed model. The first effect is related to the impact of the surrounding medium on the termination of the pulsar wind. Inside the disk, the 'early' termination of the wind results in suppression of its gamma-ray luminosity. When the pulsar escapes the disk, the conditions for termination of the wind undergo significant changes. This would lead to a dramatic increase of the pulsar wind zone, and thus to the proportional increase of the gamma-ray flux. On the other hand, if the parts of the CD disturbed by the pulsar can supply infrared photons of density high enough for efficient Comptonization of the wind, almost the entire kinetic energy of the pulsar wind would be converted to radiation, thus the gamma-ray luminosity of the wind could approach the level of the pulsar's spin-down luminosity as reported by the Fermi Collaboration.

  14. Three-dimensional parametric mapping in quantitative micro-CT imaging of post-surgery femoral head-neck samples: preliminary results

    PubMed Central

    Giannotti, Stefano; Bottai, Vanna; Panetta, Daniele; De Paola, Gaia; Tripodi, Maria; Citarelli, Carmine; Dell’Osso, Giacomo; Lazzerini, Ilaria; Salvadori, Piero Antonio; Guido, Giulio

    2015-01-01

    Summary Osteoporosis and pathological increased occurrence of fractures are an important public health problem. They may affect patients’ quality of life and even increase mortality of osteoporotic patients, and consequently represent a heavy economic burden for national healthcare systems. The adoption of simple and inexpensive methods for mass screening of population at risk may be the key for an effective prevention. The current clinical standards of diagnosing osteoporosis and assessing the risk of an osteoporotic bone fracture include dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT) for the measurement of bone mineral density (BMD). Micro-computed tomography (micro-CT) is a tomographic imaging technique with very high resolution allowing direct quantification of cancellous bone microarchitecture. The Authors performed micro-CT analysis of the femoral heads harvested from 8 patients who have undergone surgery for hip replacement for primary and secondary degenerative disease to identify possible new morphometric parameters based on the analysis of the distribution of intra-subject microarchitectural parameters through the creation of parametric images. Our results show that the micro-architectural metrics commonly used may not be sufficient for the realistic assessment of bone microarchitecture of the femoral head in patients with hip osteoarthritis. The innovative micro-CT approach considers the entire femoral head in its physiological shape with all its components like cartilage, cortical layer and trabecular region. The future use of these methods for a more detailed study of the reaction of trabecular bone for the internal fixation or prostheses would be desirable. PMID:26811703

  15. Three-dimensional parametric mapping in quantitative micro-CT imaging of post-surgery femoral head-neck samples: preliminary results.

    PubMed

    Giannotti, Stefano; Bottai, Vanna; Panetta, Daniele; De Paola, Gaia; Tripodi, Maria; Citarelli, Carmine; Dell'Osso, Giacomo; Lazzerini, Ilaria; Salvadori, Piero Antonio; Guido, Giulio

    2015-01-01

    Osteoporosis and pathological increased occurrence of fractures are an important public health problem. They may affect patients' quality of life and even increase mortality of osteoporotic patients, and consequently represent a heavy economic burden for national healthcare systems. The adoption of simple and inexpensive methods for mass screening of population at risk may be the key for an effective prevention. The current clinical standards of diagnosing osteoporosis and assessing the risk of an osteoporotic bone fracture include dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT) for the measurement of bone mineral density (BMD). Micro-computed tomography (micro-CT) is a tomographic imaging technique with very high resolution allowing direct quantification of cancellous bone microarchitecture. The Authors performed micro-CT analysis of the femoral heads harvested from 8 patients who have undergone surgery for hip replacement for primary and secondary degenerative disease to identify possible new morphometric parameters based on the analysis of the distribution of intra-subject microarchitectural parameters through the creation of parametric images. Our results show that the micro-architectural metrics commonly used may not be sufficient for the realistic assessment of bone microarchitecture of the femoral head in patients with hip osteoarthritis. The innovative micro-CT approach considers the entire femoral head in its physiological shape with all its components like cartilage, cortical layer and trabecular region. The future use of these methods for a more detailed study of the reaction of trabecular bone for the internal fixation or prostheses would be desirable. PMID:26811703

  16. Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase

    PubMed Central

    Janes, Kali; Doyle, Timothy; Bryant, Leesa; Esposito, Emanuela; Cuzzocrea, Salvatore; Ryerse, Jan; Bennett, Gary J.; Salvemini, Daniela

    2016-01-01

    Many of the widely used anticancer drugs induce dose-limiting peripheral neuropathies that undermine their therapeutic efficacy. Animal models of chemotherapy-induced painful peripheral neuropathy (CIPN) evoked by a variety of drug classes, including taxanes, vinca alkaloids, platinum-complexes, and proteasome-inhibitors, suggest that the common underlying mechanism in the development of these neuropathies is mitotoxicity in primary nerve sensory axons (PNSAs) arising from reduced mitochondrial bioenergetics [eg adenosine triphosphate (ATP) production deficits due to compromised respiratory complex I and II activity]. The causative mechanisms of this mitotoxicity remain poorly defined. However, peroxynitrite, an important pro-nociceptive agent, has been linked to mitotoxicity in several disease states and may also drive the mitotoxicity associated with CIPN. Our findings reveal that the development of mechano-hypersensitivity induced by paclitaxel, oxaliplatin, and bortezomib was prevented by administration of the peroxynitrite decomposition catalyst Mn(III) 5,10,15,20-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin (MnTE-2-PyP5+) without interfering with their anti-tumor effects. Peak CIPN was associated with the nitration and inactivation of superoxide dismutase in the mitochondria, but not in the cytosol, as well as a significant decrease in ATP production within the PNSAs; all of these events were attenuated by MnTE-2-PyP5+. Our results provide continued support for the role of mitotoxicity in the development of CIPN across chemotherapeutic drug classes, and identify peroxynitrite as a key mediator in these processes, thereby providing the rationale towards development of “peroxynitrite-targeted” therapeutics for CIPN. PMID:23891899

  17. Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice

    PubMed Central

    Shearn, Colin T.; Fritz, Kristofer S.; Shearn, Alisabeth H.; Saba, Laura M.; Mercer, Kelly E.; Engi, Bridgette; Galligan, James J.; Zimniak, Piotr; Orlicky, David J.; Ronis, Martin J.; Petersen, Dennis R.

    2015-01-01

    Chronic alcohol consumption induces hepatic oxidative stress resulting in production of highly reactive electrophilic α/β-unsaturated aldehydes that have the potential to modify proteins. A primary mechanism of reactive aldehyde detoxification by hepatocytes is through GSTA4-driven enzymatic conjugation with GSH. Given reports that oxidative stress initiates GSTA4 translocation to the mitochondria, we hypothesized that increased hepatocellular damage in ethanol (EtOH)-fed GSTA4−/− mice is due to enhanced mitochondrial protein modification by reactive aldehydes. Chronic ingestion of EtOH increased hepatic protein carbonylation in GSTA4−/− mice as evidenced by increased 4-HNE and MDA immunostaining in the hepatic periportal region. Using mass spectrometric analysis of biotin hydrazide conjugated carbonylated proteins, a total of 829 proteins were identified in microsomal, cytosolic and mitochondrial fractions. Of these, 417 were novel to EtOH models. Focusing on mitochondrial fractions, 1.61-fold more carbonylated proteins were identified in EtOH-fed GSTA4−/− mice compared to their respective WT mice ingesting EtOH. Bioinformatic KEGG pathway analysis of carbonylated proteins from the mitochondrial fractions revealed an increased propensity for modification of proteins regulating oxidative phosphorylation, glucose, fatty acid, glutathione and amino acid metabolic processes in GSTA4−/− mice. Additional analysis revealed sites of reactive aldehyde protein modification on 26 novel peptides/proteins isolated from either SV/GSTA4−/− PF or EtOH fed mice. Among the peptides/proteins identified, ACSL, ACOX2, MTP, and THIKB contribute to regulation of fatty acid metabolism and ARG1, ARLY, and OAT, which regulate nitrogen and ammonia metabolism having direct relevance to ethanol-induced liver injury. These data define a role for GSTA4-4 in buffering hepatic oxidative stress associated with chronic alcohol consumption and that this GST isoform plays an

  18. Decreased expression of plastidial adenylate kinase in potato tubers results in an enhanced rate of respiration and a stimulation of starch synthesis that is attributable to post-translational redox-activation of ADP-glucose pyrophosphorylase.

    PubMed

    Oliver, Sandra N; Tiessen, Axel; Fernie, Alisdair R; Geigenberger, Peter

    2008-01-01

    Adenine nucleotides are of general importance for many aspects of cell function, but their role in the regulation of biosynthetic processes is still unclear. It was previously reported that decreased expression of plastidial adenylate kinase, catalysing the interconversion of ATP and AMP to ADP, leads to increased adenylate pools and starch content in transgenic potato tubers. However, the underlying mechanisms were not elucidated. Here, it is shown that decreased expression of plastidial adenylate kinase in growing tubers leads to increased rates of respiratory oxygen consumption and increased carbon fluxes into starch. Increased rates of starch synthesis were accompanied by post-translational redox-activation of ADP-glucose pyrophosphorylase (AGPase), catalysing the key regulatory step of starch synthesis in the plastid, while there were no substantial changes in metabolic intermediates or sugar levels. A similar increase in post-translational redox-activation of AGPase was found after supplying adenine to wild-type potato tuber discs to increase adenine nucleotide levels. Results provide first evidence for a link between redox-activation of AGPase and adenine nucleotide levels in plants.

  19. Clobazam is equally safe and efficacious for seizures associated with Lennox-Gastaut syndrome across different age groups: Post hoc analyses of short- and long-term clinical trial results.

    PubMed

    Ng, Yu-Tze; Conry, Joan; Mitchell, Wendy G; Buchhalter, Jeffrey; Isojarvi, Jouko; Lee, Deborah; Drummond, Rebecca; Chung, Steve

    2015-05-01

    The peak age at onset of Lennox-Gastaut syndrome (LGS) is between 3 and 5years. Patients with LGS frequently experience multiple types of treatment-refractory seizures and require lifelong therapy with several antiepileptic drugs. Here, post hoc analyses of clinical trials (phase III trial OV-1012 and open-label extension trial OV-1004) provide short- and long-term efficacy and safety data of adjunctive clobazam in patients with LGS stratified by age at baseline (≥2 to <12years, ≥12 to <17years, and ≥17years). In OV-1012, 301 patients were screened, 238 were randomized, 217 comprised the modified intention-to-treat population, and 177 completed the study. A total of 267/306 patients (61 of 68 from phase II trial OV-1002 and 206 of 238 from phase III trial OV-1012) entered the open-label extension trial. Demographics and clinical characteristics were similar between different age groups in OV-1012 and OV-1004. No differences in efficacy or adverse events were observed across age groups in OV-1012 and OV-1004. The results of these post hoc analyses show that adjunctive clobazam over the short and longterm was similarly effective and well-tolerated in both pediatric and adult patients with LGS.

  20. Mid-way and post-intervention effects on potential determinants of physical activity and sedentary behavior, results of the HEIA study - a multi-component school-based randomized trial

    PubMed Central

    2012-01-01

    Background There is limited knowledge as to whether obesity prevention interventions are able to produce change in the determinants hypothesized to precede change in energy balance-related behaviors in young people. The aim of this study was to evaluate the effect of a multi-component intervention on a wide range of theoretically informed determinants of physical activity (PA) and sedentary behavior (SB). Moderation effects of gender, weight status and parental education level and whether the perceived intervention dose received influenced the effects were also explored. Methods The HEIA study was a 20-month school-based, randomized controlled trial to promote healthy weight development. In total, 1418 11-year-olds participated at baseline and post-intervention assessment. Enjoyment, self-efficacy, perceived social support from parents, teachers and friends related to PA, perceived parental regulation of TV-viewing and computer/game-use and perceived social inclusion at schools were examined by covariance analyses to assess overall effects and moderation by gender, weight status and parental education, mid-way and post-intervention. Covariance analyses were also used to examine the role of intervention dose received on change in the determinants. Results At mid-way enjoyment (p = .03), perceived social support from teachers (p = .003) and self-efficacy (p = .05) were higher in the intervention group. Weight status moderated the effect on self-efficacy, with a positive effect observed among the normal weight only. At post-intervention results were sustained for social support from teachers (p = .001), while a negative effect was found for self-efficacy (p = .02). Weight status moderated the effect on enjoyment, with reduced enjoyment observed among the overweight. Moderation effects for parental education level were detected for perceived social support from parents and teachers. Finally, positive effects on several determinants were observed

  1. Is herpes zoster an additional complication in old age alongside comorbidity and multiple medications? Results of the post hoc analysis of the 12-month longitudinal prospective observational ARIZONA cohort study

    PubMed Central

    Pickering, Gisèle; Gavazzi, Gaëtan; Gaillat, Jacques; Paccalin, Marc; Bloch, Karine; Bouhassira, Didier

    2016-01-01

    Objectives To examine the burden of comorbidity, polypharmacy and herpes zoster (HZ), an infectious disease, and its main complication post-herpetic neuralgia (PHN) in young (50–70 years of age: 70−) and old (≥70 years of age: 70+) patients. Design Post hoc analysis of the results of the 12-month longitudinal prospective multicentre observational ARIZONA cohort study. Settings and participants The study took place in primary care in France from 20 November 2006 to 12 September 2008. Overall, 644 general practitioners (GPs) collected data from 1358 patients aged 50 years or more with acute eruptive HZ. Outcome measures Presence of HZ-related pain or PHN (pain persisting >3 months) was documented at day 0 and at months 3, 6, and 12. To investigate HZ and PHN burden, pain, quality of life (QoL) and mood were self-assessed using validated questionnaires (Zoster Brief Pain Inventory, 12-item Short-Form health survey and Hospital Anxiety and Depression Scale, respectively). Results As compared with younger patients, older patients more frequently presented with comorbidities, more frequently took analgesics and had poorer response on all questionnaires, indicating greater burden, at inclusion. Analgesics were more frequently prescribed to relieve acute pain or PHN in 70+ than 70− patients. Despite higher levels of medication prescription, poorer pain relief and poorer response to all questionnaires were reported in 70+ than 70− patients. Conclusions Occurrence of HZ and progression to PHN adds extra burden on top of pharmacological treatment and impaired quality of life, especially in older patients who already have health problems to cope with in everyday life. PMID:26892790

  2. Post-traumatic brachymetatarsia.

    PubMed

    Marcinko, D E; Rappaport, M J; Gordon, S

    1984-01-01

    A case report of post-traumatic brachymetatarsia of the fourth right metatarsal is presented. The literature is reviewed and surgical alternatives are discussed. Treatment consisted of a step-up elongational osteotomy with good results and rapid patient recovery. PMID:6520345

  3. Post-operative use of knee brace in bone-tendon-bone patellar tendon anterior cruciate ligament reconstruction: 5-year follow-up results of a randomized prospective study.

    PubMed

    Harilainen, A; Sandelin, J

    2006-02-01

    Sixty patients were prospectively randomized to brace and no-brace groups after bone-tendon-bone patellar tendon anterior cruciate ligament (ACL) reconstruction. The brace group wore a rehabilitation knee brace for 12 weeks post-operatively, while the no-brace group was mobilized immediately, and crutches were discarded 2 weeks post-operatively. The groups were comparable with respect to age, gender, time from injury to surgery and concomitant injuries. There were no differences either pre-operatively or 5 years post-operatively (80% of patients reviewed) between the groups in terms of the knee score (Lysholm), activity level (Tegner), degree of laxity or isokinetic peak muscle torque. Thus it appears that knee braces are not needed in the post-operative rehabilitation after ACL reconstruction with the patellar tendon graft.

  4. Cost-utility analysis of a one-time supervisor telephone contact at 6-weeks post-partum to prevent extended sick leave following maternity leave in The Netherlands: results of an economic evaluation alongside a randomized controlled trial

    PubMed Central

    2011-01-01

    Background Working women of childbearing age are a vital part of the population. Following childbirth, this group of women can experience a myriad of physical and mental health problems that can interfere with their ability to work. Currently, there is little known about cost-effective post-partum interventions to prevent work disability. The purpose of the study was to evaluate whether supervisor telephone contact (STC) during maternity leave is cost-effective from a societal perspective in reducing sick leave and improving quality-adjusted life years (QALYs) compared to common practice (CP). Methods We conducted an economic evaluation alongside a randomized controlled trial. QALYs were measured by the EuroQol 5-D, and sick leave and presenteeism by the Health and work Performance Questionnaire. Resource use was collected by questionnaires. Data were analysed according to intention-to-treat. Missing data were imputed via multiple imputation. Uncertainty was estimated by 95% confidence intervals, cost-utility planes and curves, and sensitivity analyses. Results 541 working women from 15 companies participated. Response rates were above 85% at each measurement moment. At the end of the follow-up, no statistically significant between-group differences in QALYs, mean hours of sick leave or presenteeism or costs were observed. STC was found to be less effective and more costly. For willingness-to-pay levels from €0 through €50,000, the probability that STC was cost-effective compared to CP was 0.2. Overall resource use was low. Mean total costs were €3678 (95% CI: 3386; 3951). Productivity loss costs represented 37% of the total costs and of these costs, 48% was attributable to sick leave and 52% to work presenteeism. The cost analysis from a company's perspective indicated that there was a net cost associated with the STC intervention. Conclusions STC was not cost-effective compared to common practice for a healthy population of working mothers; therefore

  5. A post-trial survey to assess the impact of dissemination of results and unmasking on participants in a 13-year randomised controlled trial on age-related cataract

    PubMed Central

    2011-01-01

    Background The Italian-American Clinical Trial of Nutritional Supplements and Age-Related Cataract was designed to assess the impact of a multivitamin-mineral supplement on age-related cataract. Trial results showed evidence of a beneficial effect of the supplement on all types of cataract combined, opposite effects on two of the three types of cataract (beneficial for nuclear opacities and harmful for posterior sub-capsular opacities) and no statistically significant effect on cortical opacities. No treatment recommendations were made. A post-trial survey was conducted on 817 surviving elderly participants to assess their satisfaction, their understanding of treatment assignment to supplement or placebo and the success of masking. Methods Trial results were communicated by letter and the level of satisfaction and of understanding of the results was assessed by a questionnaire. Participants were offered the option of being unmasked: a second questionnaire was administered to this subset to assess their understanding of the randomisation process and the success of masking. Results 610 participants (74.7%) responded to the survey: 94.6% thought the description of the results was "very clear" or "quite clear", 5.4% "not clear" or "do not know"; 89.8% considered the results "very interesting" or "quite interesting", 10.2% "not interesting" or "do not know"; 60.3% expressed "satisfaction", 17.2% "both satisfaction and concern", 2.6% "concern", 19.9% "indifference" or "do not know". 480 participants (78.7%) accepted the offer to be unmasked to their treatment assignment: 395 (82.3%) recalled/understood the possibility of assignment to vitamins or placebo, 85 (17.7%) did not. 68 participants (17.2%) thought they had taken vitamins (79.4% were correct; p = 0.0006), 47 (11.9%) thought they had taken placebo (59.6% were correct; p = 0.46) and 280 (70.9%) declared they did not know. Conclusions The results were made difficult to explain to study participants by the

  6. Reading & Writing Workshop. The Fantastic Harry Potter.

    ERIC Educational Resources Information Center

    Lockman, Darcy

    2000-01-01

    Discusses the Harry Potter series by J.K. Rowling, explaining how to use it to enhance reading and writing instruction. The article presents a brief interview with J.K. Rowling, a Harry Potter time line, and ideas for working on writing and editing paragraphs, creating dynamic dialogue, and fixing grammar and punctuation. Other fantasy books are…

  7. At Saturn: Tripping the Flight Fantastic

    NASA Astrophysics Data System (ADS)

    Porco, Carolyn C.

    2008-05-01

    Boulder planetary scientist Carolyn Porco, leader of the imaging team for NASA's Cassini mission to Saturn and science advisor for the forthcoming movie "Star Trek," guides you on a magical mystery tour around the ringed planet. Come and witness the wonders, discoveries, and the awesome natural beauty of this amazing planet and its family of rings and moons.

  8. Fantastic Four Galaxies with Planet (Artist Concept)

    NASA Technical Reports Server (NTRS)

    2007-01-01

    This artist's concept shows what the night sky might look like from a hypothetical planet around a star tossed out of an ongoing four-way collision between big galaxies (yellow blobs). NASA's Spitzer Space Telescope spotted this 'quadruple merger' of galaxies within a larger cluster of galaxies located nearly 5 billion light-years away.

    Though the galaxies appear intact, gravitational disturbances have caused them to stretch and twist, flinging billions of stars into space -- nearly three times as many stars as are in our Milky Way galaxy. The tossed stars are visible in the large plume emanating from the central, largest galaxy. If any of these stars have planets, their night skies would be filled with the monstrous merger, along with other galaxies in the cluster (smaller, bluish blobs).

    This cosmic smash-up is the largest known merger between galaxies of a similar size. While three of the galaxies are about the size of our Milky Way galaxy, the fourth (center of image) is three times as big. All four of the galaxies, as well as most other galaxies in the huge cluster, are blob-shaped ellipticals instead of spirals like the Milky Way.

    Ultimately, in about one hundred million years or so, the four galaxies E will unite into one. About half of the stars kicked out during the merger will fall back and join the new galaxy, making it one of the biggest galaxies in the universe.

  9. Fantastic Journey through Minds and Machines.

    ERIC Educational Resources Information Center

    Muir, Michael

    Intended for learners with a basic familiarity with the Logo programming language, this manual is designed to introduce them to artificial intelligence and enhance their programming capabilities. Nine chapters discuss the following features of Logo: (1) MAZE.MASTER, a look at robots and how sensors make machines aware of their environment; (2)…

  10. Eclipsing the Light...Fantastic! Teaching Science.

    ERIC Educational Resources Information Center

    Leyden, Michael B.

    1995-01-01

    Features the concepts of optics and geometry of eclipses. Presents the "eclipse rule," suggesting classroom activities in which students derive this rule. Includes some triangles activities for outdoors that illustrate eclipsing and sighting phenomena. (ET)

  11. Fantastic voyage: designing self-powered nanorobots.

    PubMed

    Sengupta, Samudra; Ibele, Michael E; Sen, Ayusman

    2012-08-20

    The use of swarms of nanobots to perform seemingly miraculous tasks is a common trope in the annals of science fiction.1 Although several of these remarkable feats are still very much in the realm of fiction, scientists have recently overcome many of the physical challenges associated with operating on the small scale and have generated the first generation of autonomous self-powered nanomotors and pumps. The motors can be directed by chemical and light gradients, pick up and deliver cargo, and exhibit collective behavior.

  12. Post modern medicine.

    PubMed

    Dacher, E S

    1996-01-01

    Although there is general agreement that our current approach to health and healing is undergoing substantial change, there has been a lack of critical discussion regarding the extent, character, and direction of that change. It is important for us to articulate the values that we would like expressed in a reconfigured approach to health and healing, and to ensure that our efforts to initiate change are aligned with these values. An overview of western history suggests that the post-modern world view is characterized by four essential values: multidimensional realism, intentionality, holism, and personal authenticity. Our current efforts to change the direction of health care have failed to produce fundamental change. This has resulted from the compelling influence of existing perspectives and the promotion of parochial professional and institutional interests. To assure fundamental change, values that are consistent with a post-modern world must be articulated, fostered, and embedded into innovative programs.

  13. Adjuvant treatment with interleukin-2- and interferon-alpha2a-based chemoimmunotherapy in renal cell carcinoma post tumour nephrectomy: Results of a prospectively randomised Trial of the German Cooperative Renal Carcinoma Chemoimmunotherapy Group (DGCIN)

    PubMed Central

    Atzpodien, J; Schmitt, E; Gertenbach, U; Fornara, P; Heynemann, H; Maskow, A; Ecke, M; Wöltjen, H H; Jentsch, H; Wieland, W; Wandert, T; Reitz, M

    2005-01-01

    We conducted a prospectively randomised clinical trial to investigate the role of adjuvant outpatient immunochemotherapy administered postoperatively in high-risk patients with renal cell carcinoma. In total, 203 renal carcinoma patients' status post radical tumour nephrectomy were stratified into three risk groups: patients with tumour extending into renal vein/vena cava or invading beyond Gerota's fascia (pT3b/c pN0 or pT4pN0), patients with locoregional lymph node infiltration (pN+), and patients after complete resection of tumour relapse or solitary metastasis (R0). Patients were randomised to undergo either (A) 8 weeks of outpatient subcutaneous interleukin-2 (sc-rIL-2), subcutaneous interferon-alpha2a (sc-rIFN-α2a), and intravenous 5-fluorouracil (iv-5-FU) according to the standard Atzpodien regimen (Atzpodien et al, 2004) or (B) observation. Two-, 5-, and 8-year survival rates were 81, 58, and 58% in the treatment arm, and 91, 76, and 66% in the observation arm (log rank P=0.0278), with a median follow-up of 4.3 years. Two, 5-, and 8-year relapse-free survival rates were calculated at 54, 42, and 39% in the treatment arm, and at 62, 49, and 49% in the observation arm (log rank P=0.2398). Stage-adapted subanalyses revealed no survival advantages of treatment over observation, as well. Our results established that there was no relapse-free survival benefit and the overall survival was inferior with an adjuvant 8-week-outpatient sc-rIL-2/sc-rIFN-α2a/iv-5-FU-based immunochemotherapy compared to observation in high-risk renal cell carcinoma patients following radical tumour nephrectomy. PMID:15756254

  14. Meso- and microscale vein structures in fore-arc basalts and boninites related to post-magmatic tectonic deformation in the outer Izu-Bonin-Mariana fore arc system: preliminary results from IODP Expedition 352

    NASA Astrophysics Data System (ADS)

    Quandt, Dennis; Micheuz, Peter; Kurz, Walter

    2016-04-01

    The International Ocean Discovery Program (IODP) Expedition 352 aimed to drill through the entire volcanic sequence of the Izu-Bonin-Mariana fore arc. Two drill sites are situated on the outer fore arc composed of fore arc basalts (FAB) whereas two more sites are located on the upper trench slope penetrating the younger boninites. First results from IODP Expedition 352 and preliminary post-cruise data suggest that FAB were generated by decompression melting during near-trench sea-floor spreading, and that fluids from the subducting slab were not involved in their genesis. Subduction zone fluids involved in boninite genesis appear to have been derived from progressively higher temperatures and pressures over time as the subducting slab thermally matured. Structures within the drill cores combined with borehole and site survey seismic data indicate that tectonic deformation in the outer Izu-Bonin-Mariana fore arc is mainly post-magmatic associated with the development of syn-tectonic sedimentary basins. Within the magmatic basement deformation was accommodated by shear along cataclastic fault zones and the formation of tension fractures, shear fractures and hybrid (tension and shear) fractures. Veins form by mineral filling of tension or hybrid fractures and show no or limited observable macroscale displacement along the fracture plane. (Low Mg-) Calcite and/or various types of zeolite are the major vein constituents, where the latter are considered to be alteration products of basaltic glass. Micrite contents vary significantly and are related to neptunian dikes. In boninites calcite develops mainly blocky shapes but veins with fibrous and stretched crystals also occur in places indicating antitaxial as well as ataxial growth, respectively. In FAB calcite forms consistently blocky crystals without any microscopic identifiable growth direction suggesting precipitation from a highly supersaturated fluid under dropping fluid pressure conditions. However, fluid pressure

  15. Building the Child Wellbeing Project: Practitioners' Perspectives on the Role of Implementation Science in Strengthening Post-Care Child Welfare Services. Research-to-Results Brief. Publication #2012-18

    ERIC Educational Resources Information Center

    Wilson, Dawn; Brandes, Beth; Ball, Heather; Malm, Karin

    2012-01-01

    This is the third brief in a series: "Building a Post-Care Service System in Child Welfare: Lessons Learned from the Frontlines of Implementation Science in Catawba County." The first of the three briefs provided background information on the initiative that is the focus of the series--the Catawba County Child Wellbeing Project. Both Brief 2 and…

  16. [Results of the Russian EKSPERT program: post-marketing supervision over efficacy and influence of the preparation Ekvator on quality of life at out-patients with arterial hypertension].

    PubMed

    Glezer, M G; Vygodin, V A; Avakian, A A; Prokof'eva, E B

    2014-01-01

    Results of an open multicenter prospective postmarketing observational program EKSPERT (post-marketing surveillance of the effectiveness and impact of the EKVATOR treatment on quality of life in patients with arterial hypertension in ambulatory practice). Observation of 10 000 patients conducted in 300 medical center in various regions of the Russian Federation in 1005 doctors. Selected for the final analysis 4954 registration cards. It is shown that in patients with initially insufficient effective antihypertensive treatment has a large number of risk factors: men older than 55 years--56.5%, women older than 65 years--27.8%, unfavorable family history of arterial hypertension (AH)--87.9%, diabetes mellitus (DM)--13.4%, smoking--of patients 18.6%, obesity--35%, angina--35.59%, heart failure--41.3% with a history of myocardial infarction--10.9%, stroke--4.5%, renal disease--11.8%, hypercholesterolemia > 5.0 mmol/l--76.7%. Initially drug antihypertensive treatment was performed in 76.6% of patients, while 43.9% were treated regularly. Prior studies angiotensin converting enzyme inhibitors (ACE) afforded 60.56%, sartans--11% of patients, beta-blockers--41.9%, duretics--41.46%, calcium antagonists used in 21.42% of the patients. After the cancellation of previously used other ACE inhibitors, calcium antagonists and sartans patients were switched to therapy with the EKVATOR (amlodipine and lisinopril). Intensity reduction in systolic and diastolic blood pressure (SBP and DBP) did not depend on sex of the patients, the presence of angina, diabetes. Greater reduction in blood pressure in hypertensive duration more than 5 years, in the presence of congestive heart failure due to more frequent initiation of therapy with full-dose combination (amlodipine 10 mg and lisinopril 20 mg). After 1 months of starting therapy changes uorvney target blood pressure (< 140 and 90 mmHg) reached 51.5% of patients. Target SBP reached 59.7% of patients, the target level of DBP--69.4%. It is

  17. [Post-mortem microbiology analysis].

    PubMed

    Fernández-Rodríguez, Amparo; Alberola, Juan; Cohen, Marta Cecilia

    2013-12-01

    Post-mortem microbiology is useful in both clinical and forensic autopsies, and allows a suspected infection to be confirmed. Indeed, it is routinely applied to donor studies in the clinical setting, as well as in sudden and unexpected death in the forensic field. Implementation of specific sampling techniques in autopsy can minimize the possibility of contamination, making interpretation of the results easier. Specific interpretation criteria for post-mortem cultures, the use of molecular diagnosis, and its fusion with molecular biology and histopathology have led to post-mortem microbiology playing a major role in autopsy. Multidisciplinary work involving microbiologists, pathologists, and forensic physicians will help to improve the achievements of post-mortem microbiology, prevent infectious diseases, and contribute to a healthier population.

  18. [Post-mortem microbiology analysis].

    PubMed

    Fernández-Rodríguez, Amparo; Alberola, Juan; Cohen, Marta Cecilia

    2013-12-01

    Post-mortem microbiology is useful in both clinical and forensic autopsies, and allows a suspected infection to be confirmed. Indeed, it is routinely applied to donor studies in the clinical setting, as well as in sudden and unexpected death in the forensic field. Implementation of specific sampling techniques in autopsy can minimize the possibility of contamination, making interpretation of the results easier. Specific interpretation criteria for post-mortem cultures, the use of molecular diagnosis, and its fusion with molecular biology and histopathology have led to post-mortem microbiology playing a major role in autopsy. Multidisciplinary work involving microbiologists, pathologists, and forensic physicians will help to improve the achievements of post-mortem microbiology, prevent infectious diseases, and contribute to a healthier population. PMID:23195835

  19. The Mythological Substrata of Some Post-Midcentury Poems.

    ERIC Educational Resources Information Center

    Hansen, Tom

    In 1958 in their journal, "The Fifties," Robert Bly and William Duffy introduced North American readers and students to a number of European and South American poets who had developed an imagination variously described as "ecstatic,""surreal,""fantastic,""mythic," etc. That same year the American poet Donald Hall began to write poetry in a new…

  20. Reviews Book: Sustainable Energy—Without the Hot Air Equipment: Doppler Effect Unit Book: The Physics of Rugby Book: Plastic Fantastic: How the Biggest Fraud in Physics Shook the Scientific World Equipment: Brunel Eyecam Equipment: 200x Digital Microscope Book: The Atom and the Apple: Twelve Tales from Contemporary Physics Book: Physics 2 for OCR Web Watch

    NASA Astrophysics Data System (ADS)

    2009-09-01

    WE RECOMMEND Sustainable Energy—Without the Hot Air This excellent book makes sense of energy facts and figures Doppler Effect Unit Another simple, effective piece of kit from SEP Plastic Fantastic: How the Biggest Fraud in Physics Shook the Scientific World Intriguing and unique write-up of an intellectual fraud case Brunel Eyecam An affordable digital eyepiece for your microscope 200x Digital Microscope An adjustable digital flexcam for classroom use The Atom and the Apple: Twelve Tales from Contemporary Physics A fascinating round-up of the recent history of physics WORTH A LOOK The Physics of Rugby Book uses sport analogy and context to teach physics concepts Physics 2 for OCR Essential textbook for the course but otherwise pointless WEB WATCH Some free teaching materials are better than those you'd pay for

  1. Post-Newtonian gravitational bremsstrahlung

    NASA Technical Reports Server (NTRS)

    Turner, M.; Will, C. M.

    1977-01-01

    Formulae and numerical results are presented for the gravitational radiation emitted during a low-deflection encounter between two massive bodies. Results are valid through post-Newtonian order within general relativity. The gravitational waveform, the total luminosity and total emitted energy, the angular distribution of emitted energy, and the frequency spectrum are discussed in detail. A method boosting the accuracy of these quantities to post Newtonian order is also presented. A numerical comparison of results with those of Peters, and of Kovacs and Thorne shows that the post Newtonian method is reliable to better than 0.1 percent at v = 0.1 c, to a few percent at v = 0.35 c, and to 10 to 20 percent at v = 0.5 c.

  2. In vitro evaluation of glass fiber post

    PubMed Central

    Sharma, Navneet; Singh, Harpal

    2012-01-01

    Statement of problem: Techniques and recommendations for the restoration of endodontically treated teeth have changed from the use of custom cast metal post and core system to glass fiber-reinforced (GFRC) post and composite core system. Has this latest prefabricated glass fiber reinforced post and composite core system increased the fracture resistance of teeth and reduced the incidence of unrestorable root fractures. Purpose: The purpose of this study was to evaluate the incidence of root fracture and mode of failure of endodontically treated teeth restored with two different post and core systems. Material and Methods: Forty maxillary central incisors were randomly divided into two groups. (n=20). All teeth received endodontic treatment. First group was restored with custom cast post and core system. Second group was restored with glass fiber post and composite core system. In Both the groups posts were cemented with adhesive resin cement. Compressive load was applied at an angle of 130 to the long axis of teeth at a cross head speed of 1 mm/min until fracture occurred. Data were analyzed with student “t” test P<.001. Results: The mean value for fracture resistance was (331.4025) N in Group -I Custom cast Ni-Cr post and core and (237.0625) N in Group -II Glass fiber reinforced post and composite core system. Students “t” test shows the significant difference in fracture resistance of two groups. Conclusion: This study showed that the incidence of root fracture was significantly higher in custom cast Ni-Cr post and core system than glass fiber post and composite core system. A more favourable mode of failure was observed in teeth restored with Group II glass fiber post system. Key words:Post-and-core technique, glass fiber post, cast post and-core system, fracture resistance, endodontically treated teeth. PMID:24558556

  3. Post Flight Dynamic Analysis Simulation

    NASA Technical Reports Server (NTRS)

    Gregory, B. R.

    1970-01-01

    Digital six-degrees-of-freedom, open loop Saturn 5 first stage flight evaluation simulation program obtains post flight simulation of the launch vehicle using actual flight data as input. Results are compared with measured data. For preflight analysis, the program uses predicted flight data as input.

  4. Leakage of interim post and cores used during laboratory fabrication of custom posts.

    PubMed

    Demarchi, Marisa Gomes de Amorim; Sato, Elizabeth Francisco Loureiro

    2002-04-01

    The aim of this study was to compare coronal microleakage in two conditions. Twenty-eight extracted upper molars were endodontically treated and divided into two groups and controls: group A: prefabricated post and core permanently cemented; and group B: prepared for a post and restored with a temporary post crown cemented with a temporary cement. The teeth were thermocycled, immersed in black India ink for 1 week, and made transparent. Results indicated that the permanently cemented, prefabricated post and core produced the best seal (p < 0.01); leakage was significantly greater with the temporary post crown and was similar to that of a positive control group. PMID:12043875

  5. Fence Posts and Rails

    ERIC Educational Resources Information Center

    Turton, Roger

    2016-01-01

    "Mathematical Lens" uses photographs as a springboard for mathematical inquiry and appears in every issue of "Mathematics Teacher." Recently while dismantling an old wooden post-and-rail fence, Roger Turton noticed something very interesting when he piled up the posts and rails together in the shape of a prism. The total number…

  6. Current preventive strategies and management of Epstein-Barr virus-related post-transplant lymphoproliferative disease in solid organ transplantation in Europe. Results of the ESGICH Questionnaire-based Cross-sectional Survey.

    PubMed

    San-Juan, R; Manuel, O; Hirsch, H H; Fernández-Ruiz, M; López-Medrano, F; Comoli, P; Caillard, S; Grossi, P; Aguado, J M

    2015-06-01

    There is limited clinical evidence on the utility of the monitoring of Epstein-Barr virus (EBV) DNAemia in the pre-emptive management of post-transplant lymphoproliferative disease (PTLD) in solid organ transplant (SOT) recipients. We investigated current preventive measures against EBV-related PTLD through a web-based questionnaire sent to 669 SOT programmes in 35 European countries. This study was performed on behalf of the ESGICH study group from the European Society of Clinical Microbiology and Infectious Diseases. A total of 71 SOT programmes from 15 European countries participated in the study. EBV serostatus of the recipient is routinely obtained in 69/71 centres (97%) and 64 (90%) have access to EBV DNAemia assays. EBV monitoring is routinely used in 85.9% of the programmes and 77.4% reported performing pre-emptive treatment for patients with significant EBV DNAemia levels. Pre-emptive treatment for EBV DNAemia included reduction of immunosuppression in 50.9%, switch to mammalian target of rapamycin inhibitors in 30.9%, and use of rituximab in 14.5% of programmes. Imaging by whole-body 18-fluoro-deoxyglucose positron emission tomography (FDG-PET) is used in 60.9% of centres to rule out PTLD and complemented computer tomography is used in 50%. In 10.9% of centres, FDG-PET is included in the first-line diagnostic workup in patients with high-risk EBV DNAemia. Despite the lack of definitive evidence, EBV load measurements are frequently used in Europe to guide diagnostic workup and pre-emptive reduction of immunosuppression. We need prospective and controlled studies to define the impact of EBV monitoring in reducing the risk of PTLD in SOT recipients. PMID:25686696

  7. Effects of different limestone particle sizes in the diet of broiler breeders post molting on their performance, egg quality, incubation results, and pre-starter performance of their progeny.

    PubMed

    Bueno, I J M; Surek, D; Rocha, C; Schramm, V G; Muramatsu, K; Dahlke, F; Maiorka, A

    2016-04-01

    An experiment was conducted to test the hypothesis that a coarse limestone diet improves productivity, reproductive performance and the calcium utilization of molted broiler breeders. In total, 640 broiler breeder females, 73-week-old and sixty-four 27-week-old cockerels, Cobb 500, were evaluated during 10 weeks, according to a randomized block design composed of 4 treatments with 8 replicates each. Treatments consisted of diets with the inclusion of 100% fine limestone-fine PS (0.2 mm GMD-geometric mean diameter); PS1: 30% fine limestone+70% limestone with 1.0 mm GMD; PS2: 30% fine limestone+70% limestone with 2.0 mm GMD; and PS3: 30% fine limestone+70% limestone with 3.0 mm GMD. Calcium retention in the gizzard of the breeders, bone characteristics, and breeder performance, egg characteristics, eggshell quality, incubation performance, chick quality and yield, chick pre-starter live performance, and chick bone characteristics were determined. There was no significant difference (P>0.05) in the rate of lay, percentage of non-settable eggs, egg weight, egg shape index, egg specific gravity, eggshell weight, thickness, and percentage hatchability and egg weight loss of broiler breeders fed with diets with different limestone particle sizes. The chick quality and yield, chick pre-starter live performance, and chick bone characteristics were not affected (P>0.05) by any of the limestone particle sizes. It was concluded that live and reproductive performance parameters of broiler breeders post molting is not affected by limestone particle size in the feed. PMID:26769267

  8. Current preventive strategies and management of Epstein-Barr virus-related post-transplant lymphoproliferative disease in solid organ transplantation in Europe. Results of the ESGICH Questionnaire-based Cross-sectional Survey.

    PubMed

    San-Juan, R; Manuel, O; Hirsch, H H; Fernández-Ruiz, M; López-Medrano, F; Comoli, P; Caillard, S; Grossi, P; Aguado, J M

    2015-06-01

    There is limited clinical evidence on the utility of the monitoring of Epstein-Barr virus (EBV) DNAemia in the pre-emptive management of post-transplant lymphoproliferative disease (PTLD) in solid organ transplant (SOT) recipients. We investigated current preventive measures against EBV-related PTLD through a web-based questionnaire sent to 669 SOT programmes in 35 European countries. This study was performed on behalf of the ESGICH study group from the European Society of Clinical Microbiology and Infectious Diseases. A total of 71 SOT programmes from 15 European countries participated in the study. EBV serostatus of the recipient is routinely obtained in 69/71 centres (97%) and 64 (90%) have access to EBV DNAemia assays. EBV monitoring is routinely used in 85.9% of the programmes and 77.4% reported performing pre-emptive treatment for patients with significant EBV DNAemia levels. Pre-emptive treatment for EBV DNAemia included reduction of immunosuppression in 50.9%, switch to mammalian target of rapamycin inhibitors in 30.9%, and use of rituximab in 14.5% of programmes. Imaging by whole-body 18-fluoro-deoxyglucose positron emission tomography (FDG-PET) is used in 60.9% of centres to rule out PTLD and complemented computer tomography is used in 50%. In 10.9% of centres, FDG-PET is included in the first-line diagnostic workup in patients with high-risk EBV DNAemia. Despite the lack of definitive evidence, EBV load measurements are frequently used in Europe to guide diagnostic workup and pre-emptive reduction of immunosuppression. We need prospective and controlled studies to define the impact of EBV monitoring in reducing the risk of PTLD in SOT recipients.

  9. Surface evolution of manganese chloride aqueous droplets resulting in self-suppressed evaporation

    PubMed Central

    Zeng, Xiping; Zhang, Yifan; Xia, Zengzilu; Wang, Li; Wang, Cong; Huang, Yingzhou; Shen, Rong; Wen, Weijia

    2015-01-01

    The exchange kinetics of liquid water, which are of fundamental interest and have potential applications, remain unclear. A fantastic and extraordinary phenomenon was observed during the evaporation of a water droplet doped with manganese chloride. As observed from the evolution of this type of droplet, a thin film was formed on the surface with an exothermic phase transition, resulting in self-suppressed evaporation. The MnCl2-doped water droplets were maintained in a relative humidity (RH) of 50% at 40 °C for more than a week and for longer than two months at a temperature of 25 °C. In contrast, a pure water droplet can only be sustained for a few minutes. The self-suppressed evaporation of doped water may be due to the special hydration of the accumulated manganese and chloride ions at the surface, decreasing the surface tension. PMID:26292669

  10. Clobazam is efficacious for patients across the spectrum of disease severity of Lennox-Gastaut syndrome: post hoc analyses of clinical trial results by baseline seizure-frequency quartiles and VNS experience.

    PubMed

    Wheless, James W; Isojarvi, Jouko; Lee, Deborah; Drummond, Rebecca; Benbadis, Selim R

    2014-12-01

    Lennox-Gastaut syndrome (LGS) severity varies considerably, so the potential impact of differences in baseline severity on patient outcome following treatment is clinically informative. Here, two surrogate indicators of LGS severity (baseline seizure frequency and vagus nerve stimulation [VNS] use) were used in post hoc analyses of both short- and long-term clobazam trials (Phase III OV-1012 [CONTAIN] and open-label extension [OLE] OV-1004). In CONTAIN, 217 patients comprised the modified, intention-to-treat population. Each baseline seizure-frequency quartile had ~40 patients, and baseline weekly drop-seizure frequency ranges were as follows: <10 (Quartile 1), 10-30 (Quartile 2), 32-86 (Quartile 3), and 86-1077 (Quartile 4). Mean percentage decreases in average weekly drop and total seizures were similar for all quartiles. More than 50% of patients in all 4 quartiles demonstrated ≥ 50% decreases in weekly drop- and total-seizure frequency. The percentage of patients achieving 100% reduction in drop seizures was 33% for clobazam-treated patients (vs. 7% for placebo) in Quartile 1. Five percent of clobazam-treated patients in Quartile 4 (most severe LGS) vs. 0% for placebo achieved 100% reduction in drop seizures. A total of 267 of 306 possible patients entered the OLE (61/68 from a Phase II study and 206/238 from Phase III CONTAIN). Each quartile had ~66 patients, and baseline weekly drop-seizure ranges were as follows: <10 (Quartile 1), 10-31 (Quartile 2), 32-110 (Quartile 3), and 111-1147 (Quartile 4). Median percentage decreases in average weekly drop and total seizures were similar between quartiles. Through 5 years of therapy, >50% of patients in all 4 quartiles demonstrated ≥ 50% decreases in weekly frequency for drop seizures. More than 12% of patients in Quartile 4 achieved 100% reduction in drop seizures from Month 3 through Year 5. For the VNS analyses in CONTAIN, the least-squares mean decreases in average weekly rate of drop seizures (m

  11. Development of a Novel Gas Pressurized Process-Based Technology for CO2 Capture from Post-Combustion Flue Gases Preliminary Year 1 Techno-Economic Study Results and Methodology for Gas Pressurized Stripping Process

    SciTech Connect

    Chen, Shiaoguo

    2013-03-01

    Under the DOE’s Innovations for Existing Plants (IEP) Program, Carbon Capture Scientific, LLC (CCS) is developing a novel gas pressurized stripping (GPS) process to enable efficient post-combustion carbon capture (PCC) from coal-fired power plants. A technology and economic feasibility study is required as a deliverable in the project Statement of Project Objectives. This study analyzes a fully integrated pulverized coal power plant equipped with GPS technology for PCC, and is carried out, to the maximum extent possible, in accordance to the methodology and data provided in ATTACHMENT 3 – Basis for Technology Feasibility Study of DOE Funding Opportunity Number: DE-FOA-0000403. The DOE/NETL report on “Cost and Performance Baseline for Fossil Energy Plants, Volume 1: Bituminous Coal and Natural Gas to Electricity (Original Issue Date, May 2007), NETL Report No. DOE/NETL-2007/1281, Revision 1, August 2007” was used as the main source of reference to be followed, as per the guidelines of ATTACHMENT 3 of DE-FOA-0000403. The DOE/NETL-2007/1281 study compared the feasibility of various combinations of power plant/CO2 capture process arrangements. The report contained a comprehensive set of design basis and economic evaluation assumptions and criteria, which are used as the main reference points for the purpose of this study. Specifically, Nexant adopted the design and economic evaluation basis from Case 12 of the above-mentioned DOE/NETL report. This case corresponds to a nominal 550 MWe (net), supercritical greenfield PC plant that utilizes an advanced MEAbased absorption system for CO2 capture and compression. For this techno-economic study, CCS’ GPS process replaces the MEA-based CO2 absorption system used in the original case. The objective of this study is to assess the performance of a full-scale GPS-based PCC design that is integrated with a supercritical PC plant similar to Case 12 of the DOE/NETL report, such that it corresponds to a nominal 550 MWe

  12. Post-16 update

    NASA Astrophysics Data System (ADS)

    1999-07-01

    (post16) Faces of Physics To study a physics course post-16 is take out an option on your future. But physics itself is very varied, and so is what you might do with it. It seems right that post-16 physics courses reflect important aspects of this variety. Physics varies with why people do it. As reliable knowledge, physics is often essential to making things happen. This is physics as feeding into technology, and quite often feeding off technology. The human urge here is the urge to create things that work. It drives individual inventors; it drives large teams in multinational companies. At the opposite end of this spectrum is physics driven by curiosity, by the urge to find out. The stock examples are the grand discoveries from the expansion of the universe to the discovery of the nucleus of atoms. But the physicist's curiosity is often on a more detailed, even finicky scale: how exactly do the molecules of this polymer respond to stress?; just how do ions implanted in this material modify its conductivity? It is clear to me that a decent post-16 physics course must respect and reflect both. This is by no means a matter of `basic laws and their applications'. It is a matter of recognizing two fundamental interests, in doing and in explaining, and of recognizing that they are at once closely interdependent and worlds apart. Ideas in physics are also not of one kind. One opposition is the idea of describing Nature in terms of deterministic physical laws, as against describing Nature as the predictable outcome of probabilistic behaviour `underneath'. The first has gripped the Western imagination since at least the time of Descartes. The second has increasingly come to the fore, especially in thermodynamics with the idea that we can only make processes work by fixing the circumstances so that uncaring atoms and molecules happen by chance to do what we want. Now in quantum theory both ideas - determinism and randomness - co-exist. Post-16 physics courses are not in

  13. 19. GROUND STORY, POST OFFICE LOBBY DETAIL OF POST OFFICE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. GROUND STORY, POST OFFICE LOBBY DETAIL OF POST OFFICE BOXES ALONG WEST WALL OF LEXINGTON AVENUE ARM - Grand Central Post Office Annex, Forty-fifth Street & Lexington Avenue, Southwest corner, New York County, NY

  14. 16. FLOOR 1; MASSIVE CENTER POST IS THE MAIN POST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. FLOOR 1; MASSIVE CENTER POST IS THE MAIN POST OF A 1736 POST MILL WHICH THIS MILL REPLACED; MORTISE FOR QUARTER BAR CAN BE SEEN - Hook Windmill, North Main Street at Pantigo Road, East Hampton, Suffolk County, NY

  15. Post-Polio Syndrome

    MedlinePlus

    ... Funding Information Research Programs Training & Career Awards Enhancing Diversity Find People About NINDS NINDS Post-Polio Syndrome ... News From NINDS | Find People | Training | Research | Enhancing Diversity Careers@NINDS | FOIA | Accessibility Policy | Contact Us | Privacy ...

  16. Post-16 update

    NASA Astrophysics Data System (ADS)

    1999-01-01

    . It requires good use of computers. Other examples: use modern imaging methods to teach information processing and optics; study `designer materials' to reflect both the inventiveness and the curiosity of physicists. Tell stories from fundamental efforts to understand the world: forces and motion, waves and photons, the structure of the Universe, a hint of relativity. The new AS course has to fit QCA criteria, but should also look beyond them to suggest how to shape the future of A-level physics. Jon Ogborn Director, Institute of Physics Post-16 Initiative The study of matter The study of matter is as central to pure physics as it is to technological applications. Currently Advanced GNVQ Science requires much more detailed knowledge of materials than most A-level courses. But in every case, what 16 - 19 year-old students experience is a rather dated study of engineering materials, with an emphasis on mechanical properties. Almost entirely absent is the notion of our new ability to design materials. Recently, new techniques of visualization, modelling the hierarchy of structures inside a material and simulating the resulting changes in properties, have all dramatically changed the nature of materials science. Post-16 physics courses should mention some new classes of materials responsible for major industrial and social changes. For example, let's look at `soft matter' such as polymers, liquid crystals and emulsions. These are the stuff of Nature, which we are only now learning to imitate. The continuing miniaturization of computer chips and sensors is based on functional properties - optical, electrical, thermal or magnetic. If students are to understand and perhaps later to contribute to developments such as these, they deserve a better introduction. Careful thinking needs to go into deciding what a basic course might entail. But what topic could be better suited to coursework in the form of student research? Teaching about matter in an up-to-date way may sound too

  17. Esthetic Intracanal Posts

    PubMed Central

    Parčina, Ivana; Amižić

    2016-01-01

    The primary function of an endodontic post is to provide retention for the core and enable full sealing of the coronal portion of the root canal. Traditionally used metal posts do not meet the requirements of modern dental medicine due to some fairly significant drawbacks such as color, corrosion potential, non-adhesive bonding and high modulus of elasticity which can lead to root fracture. Recently, esthetic ceramic and fiber reinforced posts have been manufactured in order to avoid such imperfections. Since much attention has been devoted to the esthetic aspects of dental medicine, the use of these posts with composite/ceramic cores is very common in restorative dentistry and it is actually becoming a standard. This is due to the fact that, apart from being an esthetically pleasing material, they are also biocompatible, have good physical properties and the capacity of adhesive bonding to tooth tissue and core buildup. Nonetheless, a good clinician should know how to spot the difference between them in order to select and use the appropriate post system in each specific situation. PMID:27789912

  18. Orders- Versus Encounters-Based Image Capture: Implications Pre- and Post-Procedure Workflow, Technical and Build Capabilities, Resulting, Analytics and Revenue Capture: HIMSS-SIIM Collaborative White Paper.

    PubMed

    Cram, Dawn; Roth, Christopher J; Towbin, Alexander J

    2016-10-01

    The decision to implement an orders-based versus an encounters-based imaging workflow poses various implications to image capture and storage. The impacts include workflows before and after an imaging procedure, electronic health record build, technical infrastructure, analytics, resulting, and revenue. Orders-based workflows tend to favor some imaging specialties while others require an encounters-based approach. The intent of this HIMSS-SIIM white paper is to offer lessons learned from early adopting institutions to physician champions and informatics leadership developing strategic planning and operational rollouts for specialties capturing clinical multimedia. PMID:27417208

  19. Orders- Versus Encounters-Based Image Capture: Implications Pre- and Post-Procedure Workflow, Technical and Build Capabilities, Resulting, Analytics and Revenue Capture: HIMSS-SIIM Collaborative White Paper.

    PubMed

    Cram, Dawn; Roth, Christopher J; Towbin, Alexander J

    2016-10-01

    The decision to implement an orders-based versus an encounters-based imaging workflow poses various implications to image capture and storage. The impacts include workflows before and after an imaging procedure, electronic health record build, technical infrastructure, analytics, resulting, and revenue. Orders-based workflows tend to favor some imaging specialties while others require an encounters-based approach. The intent of this HIMSS-SIIM white paper is to offer lessons learned from early adopting institutions to physician champions and informatics leadership developing strategic planning and operational rollouts for specialties capturing clinical multimedia.

  20. Post-herpetic neuralgia

    PubMed Central

    Tontodonati, Monica; Ursini, Tamara; Polilli, Ennio; Vadini, Francesco; Di Masi, Francesco; Volpone, Damiano; Parruti, Giustino

    2012-01-01

    Background In spite of the large body of evidence available in the literature, definition and treatment of Post-Herpetic Neuralgia (PHN) are still lacking a consistent and universally recognized standardization. Furthermore, many issues concerning diagnosis, prediction and prevention of PHN need to be clarified in view of recent contributions. Objectives To assess whether PHN may be better defined, predicted, treated and prevented in light of recent data, and whether available alternative or adjunctive therapies may improve pain relief in treatment recalcitrant PHN. Methods Systematic reviews, meta-analyses, randomized controlled trials, cohort studies and protocols were searched; the search sources included PubMed, Cochrane Library, NICE, and DARE. More than 130 papers were selected and evaluated. Results Diagnosis of PHN is essentially clinical, but it can be improved by resorting to the many tools available, including some practical and accessible questionnaires. Prediction of PHN can be now much more accurate, taking into consideration a few well validated clinical and anamnestic variables. Treatment of PHN is presently based on a well characterized array of drugs and drug associations, including, among others, tricyclic antidepressants, gabapentinoids, opioids and many topical formulations. It is still unsatisfactory, however, in a substantial proportion of patients, especially those with many comorbidities and intense pain at herpes zoster (HZ) presentation, so that this frequent complication of HZ still strongly impacts on the quality of life of affected patients. Conclusion Further efforts are needed to improve the management of PHN. Potentially relevant interventions may include early antiviral therapy of acute HZ, prevention of HZ by adult vaccination, as well as new therapeutic approaches for patients experiencing PHN. PMID:23109810

  1. Evaluation of post-surface conditioning to improve interfacial adhesion in post-core restorations

    PubMed Central

    Sumitha, Mylswamy; Kothandaraman, Rajkumar; Sekar, Mahalaxmi

    2011-01-01

    Aim: To examine the influence of different post-surface treatments on the interfacial strength between epoxy resin-based fiber posts and methacrylate-based resin composites that are employed as core build-up materials. Materials and Methods: Forty clear posts were divided into four groups of 10 each. The different surface treatments used were etching with alkaline potassium permanganate, 10% hydrogen peroxide, 37% phosphoric acid, and silanization alone. After etching and thorough rinsing, a single layer of silane was applied to the post surface. Then the post was placed in a rectangular plastic matrix and core bulid-up was done using Multi Core, a dual cured composite resin. A slab of uniform thickness, with the post in the center and the core build-up composite on either side was created. The specimens were cut so as to obtain microtensile sticks that were loaded in tension at a cross-head speed of 1 mm/min until failure. The statistical analysis was performed using two-way ANOVA and the paired T test for post-hoc comparisons. Results: The results achieved with potassium permanganate had a significant influence on microtensile interfacial bond strength values with the tested material. Conclusion: Surface chemical treatments of the resin phase of fiber posts enhance the silanization efficiency of the quartz fiber phase, so that the adhesion in the post/core unit may be considered as a net sum of chemical and micromechanical retention. PMID:21691501

  2. Time-temperature profiles of post-cure composite ovens.

    PubMed

    Loza-Herrero, M A; Rueggeberg, F A

    1998-01-01

    Previous research indicates that there are improved physical properties resulting from post-cure heating of light-activated resin composite. Currently, a large variety of commercial devices and techniques are used for post-cure heating. This study determined differences among the time-temperature profiles of selected commercial post-cure devices. It also compared the biaxial flexure strength of resin composite which was post-cure heated in each device.

  3. Safe Schools Survey. Post-Secondary Student Survey. Preliminary Results.

    ERIC Educational Resources Information Center

    Minnesota State Office of the Attorney General, St. Paul.

    A survey of 706 randomly sampled students at institutions of postsecondary education in Minnesota examined students' perceptions of violence and safety at their schools. Overall findings indicated that the majority of students had not been victims of violent acts and generally felt safe at their institutions. However, many respondents indicated…

  4. The Radiometer Atmospheric Cubesat Experiment Post-Launch Results

    NASA Astrophysics Data System (ADS)

    Lim, B.; Misra, S.

    2015-12-01

    The Jet Propulsion Laboratory (JPL) developed the Radiometer Atmospheric CubeSat Experiment (RACE) that was lost during the Orbital 3 (Orb-3) launch anomaly on October 28, 2014. The 3U CubeSat mission would have measured 2 channels of the 183 GHz water vapor line and raised the technology readiness level (TRL) of various subsystems to 6. Despite the launch failure, several hundreds of hours of instrument operation data was taken, including measurements in thermal vacuum of the complete spacecraft system. These data is used to evaluate the 35 nm Indium Phosphide (InP) receivers, and the low noise amplifier (LNA) based internal calibration system. The thermal vacuum measurements included frequent observations of a 'cold' and 'hot' target allowing for various receiver parameters to be calculated. The payload thermal vacuum data show that the receiver front ends performed as expected in terms of the gain (>35 dB) and drift (0.06 dB/K). The data also shows that integration could be performed with decreasing noise up to ~30 seconds, allowing for the system to be calibrated within that time period. The expected spacecraft calibration period would have been every 12 seconds. The injected noise from the load terminated LNA show magnitudes from 50 - 150 K that can be tuned which would meet most requirements. However the temperature coefficient is large at ~3 K/K which is over an order of magnitude larger than typical noise diodes. For nanosatellite class spacecraft, the power required to properly maintain the physical temperature range (±0.1K) would be challenging. On larger spacecraft, this methodology may still be viable, depending on the availability of suitable noise diodes at 183 GHz. While the CubeSat did not take measurements in space, the ground data in the relevant environment and extensive testing allows us to raise the following subsystems to TRL 6: 1) 183 GHz 35 nm InP receiver, 2) 183 GHz direct detect receiver and 3) 183 GHz LNA based calibration system.

  5. Feature: Post Traumatic Stres Disorder PTSD: NIH Research to Results

    MedlinePlus

    ... including PTSD, persist for those affected by 2005's Hurricane Katrina. This is important because previously researchers found ... and resilience among survivors in Texas of 2008's Hurricane Ike. Other research is exploring whether certain drugs ...

  6. Post-16 update

    NASA Astrophysics Data System (ADS)

    1999-03-01

    Post-16 Initiative logo Physics in Mathematical Mood Later this year, as part of the post-16 initiative of the Institute of Physics, a booklet with the above title will be published. In draft form, the booklet was discussed at the ASE conference in January. Some of the issues raised are briefly set out here. If you have any views to contribute, please write to Simon Carson at the Institute of Physics or e-mail simon.carson@physics.org. A mathematical view of the world is intrinsically a part of physics and therefore physics should be studied in an appropriately mathematical way. However, we all know that, to some students at least, mathematics proves to be a stumbling block rather than a powerful aid to understanding. So how can we help? Realizing that as physics teachers we need to deliver the mathematics necessary to an understanding of our subject is a start. Its corollary is that we need to find the space within the physics core. We may wish to use supplementary courses such as AS mathematics or QCA's new free-standing mathematics units, but requiring additional courses as a prerequisite to a study of A-level physics may deter students. Teaching the mathematics in context may aid understanding but we also must ensure that techniques are seen in a variety of contexts and that at some point the tool is abstracted from the background. As teachers we need to be aware of the very basic mathematical difficulties that students bring with them: the use of calculators, standard form, simple algebraic manipulation, for example. Mathematical arguments need to be developed fully and carefully. Encouraging cooperation and discussion between students may help the less able to understand and the more able to appreciate and develop their own understanding through making explicit their reasoning by explaining it to others. And what of new technology? Software tools allow students to develop their understanding about graphs, for example, enabling them to investigate the

  7. Development of new radiopaque glass fiber posts.

    PubMed

    Furtos, Gabriel; Baldea, Bogdan; Silaghi-Dumitrescu, Laura

    2016-02-01

    The aim of this study was to analyze the radiopacity and filler content of three experimental glass fiber posts (EGFP) in comparison with other glass/carbon fibers and metal posts from the dental market. Three EGFP were obtained by pultrusion of glass fibers in a polymer matrix based on 2,2-bis[4-(2-hydroxy-3-methacryloyloxypropoxy)-phenyl]propane (bis-GMA) and triethyleneglycol dimethacrylate (TEGDMA) monomers. Using intraoral sensor disks 27 posts, as well as mesiodistal sections of human molar and aluminum step wedges were radiographed for evaluation of radiopacity. The percentage compositions of fillers by weight and volume were investigated by combustion analysis. Two EGFP showed radiopacity higher than enamel. The commercial endodontic posts showed radiopacity as follows: higher than enamel, between enamel and dentin, and lower than dentin. The results showed statistically significant differences (p b 0.05)when evaluatedwith one-way ANOVA statistical analysis. According to combustion analyses, the filler content of the tested posts ranges between 58.84wt.% and 86.02wt.%. The filler content of the tested EGFP ranged between 68.91 wt.% and 79.04 wt.%. EGFP could be an alternative to commercial glass fiber posts. Futureglass fiber posts are recommended to present higher radiopacity than dentin and perhaps ideally similar to or higher than that of enamel, for improved clinical detection. The posts with a lower radiopacity than dentin should be considered insufficiently radiopaque. The radiopacity of some glass fiber posts is not greatly influenced by the amount of filler. PMID:26652441

  8. Development of new radiopaque glass fiber posts.

    PubMed

    Furtos, Gabriel; Baldea, Bogdan; Silaghi-Dumitrescu, Laura

    2016-02-01

    The aim of this study was to analyze the radiopacity and filler content of three experimental glass fiber posts (EGFP) in comparison with other glass/carbon fibers and metal posts from the dental market. Three EGFP were obtained by pultrusion of glass fibers in a polymer matrix based on 2,2-bis[4-(2-hydroxy-3-methacryloyloxypropoxy)-phenyl]propane (bis-GMA) and triethyleneglycol dimethacrylate (TEGDMA) monomers. Using intraoral sensor disks 27 posts, as well as mesiodistal sections of human molar and aluminum step wedges were radiographed for evaluation of radiopacity. The percentage compositions of fillers by weight and volume were investigated by combustion analysis. Two EGFP showed radiopacity higher than enamel. The commercial endodontic posts showed radiopacity as follows: higher than enamel, between enamel and dentin, and lower than dentin. The results showed statistically significant differences (p b 0.05)when evaluatedwith one-way ANOVA statistical analysis. According to combustion analyses, the filler content of the tested posts ranges between 58.84wt.% and 86.02wt.%. The filler content of the tested EGFP ranged between 68.91 wt.% and 79.04 wt.%. EGFP could be an alternative to commercial glass fiber posts. Futureglass fiber posts are recommended to present higher radiopacity than dentin and perhaps ideally similar to or higher than that of enamel, for improved clinical detection. The posts with a lower radiopacity than dentin should be considered insufficiently radiopaque. The radiopacity of some glass fiber posts is not greatly influenced by the amount of filler.

  9. 1. Post card view of the bridge, c. 1910. Post ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Post card view of the bridge, c. 1910. Post card courtesy Carol Poh Miller. Photocopy by Berni Rich, Score Photographers Cleveland, OH - B & O Railroad Bridge Number 464, Spanning Old Ship Canal & Cuyahoga River, Cleveland, Cuyahoga County, OH

  10. Typical Newel Post, First Floor Newel Post, Typical Baluster, Typical ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Typical Newel Post, First Floor Newel Post, Typical Baluster, Typical Nosing, First Floor Stringer Profile, Second Floor Stringer Profile - National Home for Disabled Volunteer Soldiers - Battle Mountain Sanitarium, Treasurer's Quarters, 500 North Fifth Street, Hot Springs, Fall River County, SD

  11. 10. FLOOR 1; CENTER POST AND POSTS UNDER STONE BEAMS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. FLOOR 1; CENTER POST AND POSTS UNDER STONE BEAMS WHICH SUPPORT BRIDGE BEAMS FOR BRIDGE TREES; WEDGES FOR ADJUSTING HEIGHT OF BRIDGE TREE CAN BE SEEN - Shelter Island Windmill, Manwaring Road, Shelter Island, Suffolk County, NY

  12. Post-Traumatic Stress Symptoms and Post-Traumatic Growth: Evidence from a Longitudinal Study following an Earthquake Disaster

    PubMed Central

    Chen, Jieling; Zhou, Xiao; Zeng, Min; Wu, Xinchun

    2015-01-01

    Objective The current longitudinal study aims to examine the bidirectional relationship between post-traumatic stress symptoms (PTSS) and post-traumatic growth (PTG). Method One hundred twenty-two adults in the most severely affected area were investigated by self-report questionnaires at 12 months and 18 months after the Wenchuan Earthquake occurred in China. Results The autoregressive cross-lagged structure equation analysis revealed that PTG at 12 months post-earthquake could negatively predict PTSS at 18 months post-earthquake above and beyond PTSS stability, whereas PTSS at 12 months post-earthquake could not significantly predict subsequent PTG. Moreover, PTG at 12 months post-earthquake could predict fewer subsequent intrusions, numbing and hyper-arousal symptoms but not avoidance symptoms. Conclusion Growth can play a role in reducing long-term post-traumatic stress symptoms, and the implication of a positive perspective in post-trauma circumstance is discussed. PMID:26046912

  13. Post-traumatic amnesia.

    PubMed

    Marshman, Laurence A G; Jakabek, David; Hennessy, Maria; Quirk, Frances; Guazzo, Eric P

    2013-11-01

    Of patients hospitalised for traumatic brain injury (TBI), most pass through a state of altered consciousness known as "post-traumatic amnesia" (PTA). Despite the lack of a consistent definition, PTA is widely used as a construct in neurosurgical practice to guide decision-making and prognosis. Accurate PTA assessment is important, because over-evaluation leads to excess social, financial and opportunity costs, whilst under-evaluation risks patient welfare. Whilst anterograde memory is certainly disrupted in PTA, PTA in fact involves a far more extensive memory disturbance. More instructively, the complete "post-TBI syndrome" also comprises an extensive cognitive deficit which includes a confusional state, as well as a behavioural disturbance characterised by acute agitation. Recently, impairments in attention and executive functioning have also been emphasised; indeed, some consider these the primary disturbance with PTA. Although all of these features were fully described (or implied) by the earliest pioneers, most current PTA scores do not assess the complete "post-TBI syndrome". Currently, the Westmead PTA scale (WPTAS) directs most in-hospital TBI management throughout Australasia: however, in addition to general defects, specific limitations have been identified in the levels of evidence for WPTAS validity. We review the literature regarding PTA and, in particular, the continued role of the WPTAS in directing neurosurgical practice.

  14. [Post-traumatic amnesia and post-trauma quality of life].

    PubMed

    e Silva, Silvia Cristina Fürbringer; Settervall, Cristina Helena Constanti; de Sousa, Regina Marcia Cardoso

    2012-10-01

    The present study aims to compare quality of life of victims with long and short term post-traumatic amnesia and to analyze the relation between quality of life and length of amnesia, including or not the comatose period. This prospective cohort study, gathered data during the hospital stay and 3 and 6 months post- trauma. Blunt traumatic brain injury patients, over 14 years old, with no prior diagnosis of dementia or brain injury, admitted to a trauma center 12 hours post-trauma were included. The results were unfavorable among patients with long term amnesia. Correlation between length of post-traumatic amnesia and quality of life domains were more expressive when excluded comatose period, indicating that it must not be computed in the length of post-traumatic amnesia.

  15. GIRAFFE test results summary

    SciTech Connect

    Yokobori, S.; Arai, K.; Oikawa, H.

    1996-03-01

    A passive system can provide engineered safety features enhancing safety system reliability and plant simplicity. Toshiba has conducted the test Program to demonstrate the feasibility of the SBWR passive safety system using a full-height, integral system test facility GIRAFFE. The test facility GIRAFFE models the SBWR in full height to correctly present the gravity driving head forces with a 1/400 volume scale. The GIRAFFE test Program includes the certification tests of the passive containment cooling system (PCCS) to remove the post-accident decay heat and the gravity driven cooling system (GDCS) to replenish the reactor coolant inventory during a LOCA. The test results have confirmed the PCCS and GDCS design and in addition, have demonstrated the operation of the pCCS with the presence of a lighter-than-steam noncondensable as well as with the presence of a heavier-than-steam, noncondensable. The GIRAFFE test Program has also provided the database to qualify a best estimate thermal-hydraulic computer code TRAC. The post test analysis results have shown that TRAC can accurately predict the PCCS heat removal Performance and the containment pressure response to a LOCA. This paper summarizes the GIRAFFE test results to investigate post-LOCA PCCS heat removal performance and post-test analysis using TRAC.

  16. Issues in Post-Literacy.

    ERIC Educational Resources Information Center

    Dave, Ravindra H.; And Others

    1989-01-01

    Post-literacy programs attempt to prevent relapse into illiteracy by ensuring retention, application, and continued growth of literacy skills. Planning for post-literacy should be included at the outset. Post-literacy must be seen as part of the lifelong education continuum, be funded effectively, overcome social and psychological barriers, and…

  17. Sterile post-traumatic immunosuppression

    PubMed Central

    Islam, Md Nahidul; Bradley, Benjamin A; Ceredig, Rhodri

    2016-01-01

    After major trauma, the human immune system initiates a series of inflammatory events at the injury site that is later followed by suppression of local inflammation favoring the repair and remodeling of the damaged tissues. This local immune response involves complex interactions between resident cells such as macrophages and dendritic cells, soluble mediators such as cytokines and chemokines, and recruited cells such as neutrophils, monocytes and mesenchymal stromal cells. If of sufficient magnitude, these initial immune responses nevertheless have systemic consequences resulting in a state called post-traumatic immunosuppression (PTI). However, controversy exists regarding the exact immunological changes occurring in systemic compartments triggered by these local immune responses. PTI is one of the leading causes of post-surgical mortality and makes patients vulnerable to hospital-acquired infections, multiple organ failure and many other complications. In addition, hemorrhage, blood transfusion, immunesenescence and immunosuppressant drugs aggravate PTI. PTI has been intensively studied, but published results are frequently cloudy. The purpose of this review is to focus on the contributions made by different responsive modalities to immunosuppression following sterile trauma and to try to integrate these into an overall scheme of PTI. PMID:27195120

  18. [Post launch studies].

    PubMed

    Akaza, Hideyuki; Ohashi, Yasuo; Shimada, Yasuhiro; Ikeda, Tadashi; Saijo, Nagahiro; Isonishi, Seiji; Hirao, Yoshihiko; Tsuruo, Takashi; Tsukagoshi, Shigeru; Sone, Saburo; Nakamura, Seigo; Kato, Masuhiro; Mikami, Osamu; von Euler, Mikael; Blackledge, George; Milsted, Bob; Vose, Brent

    2002-11-01

    Evidence Based Medicine (EBM) is a growing concept in Japan as it is elsewhere. Central to improving the use of EBM is generation of data through well conducted controlled clinical studies. There are many problems associated with conduct of clinical studies after launch in Japan, and many initiatives are ongoing to improve the situation. Development of Clinical Research Coordinators (CRO) and central Data Management centers are key to improving the quality of clinical research in Japan. Currently Japan has an undeveloped legal system with regard to post-launch trials and off-label use of registered drugs. There is no reimbursement for off-label and various restrictions imposed on the recipients of the Ministry of Health, Labour and Welfare's (MHLW) funds. Maybe the biggest problem is the high cost of post-marketing studies sponsored by pharmaceutical manufacturers. A high quality system to support post launch clinical studies need a solid financial base. There is a need for a suitable review system for investigator initiated multi-centre studies, as the current IRB system is not sufficient. There are also challenges regarding the differences, perceived or real, in treatment practice and available registrations in Japan and in the West, causing problems in choosing suitable comparators and study designs. At the present time it is not clear whether investigator initiated trials will be acceptable for registration purposes in Japan. The agreed first priority is to build a suitable and strong infrastructure within the academic community to support researchers to investigate important questions with or without pharmaceutical company support. Despite all these issues, several groundbreaking projects are under way throughout Japan, in many different areas and by different collaborative groups, some with government support. In fact, researcher-initiated clinical trials achieved a rapid growth in Japan in the past year.

  19. Chronic Post Surgical Pain

    PubMed Central

    2011-01-01

    Chronic post-surgical pain (CPSP) is a recognised adverse consequence of surgery; surgery is common, therefore the population at risk is considerable. Putative risk factors for CPSP include genetic predisposition, demographic, clinical (pain history, type of surgery, anaesthesia, acute pain severity), and psychological factors (vulnerability vs resilience). Evidence of prevention is limited: long-term benefit from pre-emptive/perioperative analgesia has not been demonstrated consistently. Large scale prospective studies with detailed pre, intra and postoperative multifactorial assessments are required to refine understanding of the aetiology and prognosis of CPSP. PMID:26526062

  20. INC424 for Patients With Myelofibrosis, Post Polycythemia Myelofibrosis or Post-essential Thrombocythemia Myelofibrosis

    ClinicalTrials.gov

    2016-05-24

    Myelofibrosis (PMF); Post Polycythemia Myelofibrosis (PPV MF); Post-essential Thrombocythemia Myelofibrosis (PET-MF); Myelofibrosis; Post Polycythemia Myelofibrosis; Post-essential Thrombocythemia Myelofibrosis

  1. Cloverleaf Vibratory Microgyroscope with Integrated Post

    NASA Technical Reports Server (NTRS)

    Tang, Tony K.; Gutierrez, Roman; Roger, Damien

    2003-01-01

    A modified design and fabrication sequence has been devised to improve the performance of a cloverleaf vibratory microgyroscope that includes an axial rod or post rigidly attached to the center of the cloverleaf structure. The basic concepts of cloverleaf vibratory microgyroscopes, without and with rods or posts, were described in two prior articles in NASA Tech Briefs, Vol. 21, No. 9 (September 1997): Micromachined Planar Vibratory Microgyroscopes (NPO-19713), page 68 and Planar Vibratory Microgyroscope: Alternative Configuration (NPO-19714), page 70. As described in more detail in the second-mentioned prior article, the cloverleaf-shaped structure and the rod or post are parts of a vibratory element that senses rotation via the effect of the Coriolis force upon its vibrations. Heretofore, the posts for devices of this type have been fabricated separately, then assembled manually onto the cloverleaf structures. The resulting imperfections in the assembled units have given rise to asymmetric stresses in the cloverleaf structures and, consequently, to changes in resonant frequencies of vibration and in shapes of vibration modes. These changes, in turn, have caused variations in performance among nominally identical devices. The modified design provides for the fabrication of the upper half of the post as an integral part of the cloverleaf structure; this is accomplished by reactive-ion etching of a single-piece half-post-and-cloverleaf structure from a wafer of silicon. The lower half of the post and a baseplate are also a single piece made by reactive-ion etching from a wafer of silicon. The two pieces are bonded together (see figure) by a thermal-compression metal-to-metal bonding technique to form a cloverleaf gyroscope with an integrated post structure..

  2. [Post Stroke Dementia].

    PubMed

    Ihara, Masafumi

    2016-07-01

    Post-stroke dementia (PSD) is a clinical entity that encompasses all types of dementia following an index stroke. Current evidence suggests that 25-30% of ischemic stroke survivors develop immediate or delayed vascular cognitive impairment or vascular dementia. The type of stroke can be either ischemic, hemorrhagic or hypoperfusive. There are multiple risk factors for PSD including older age, family history, genetic variants, low educational status, vascular comorbidities, prior transient ischemic attack or recurrent stroke and depressive illness. Pre-stroke dementia refers to the occurrence of cognitive impairment before the index stroke, which may be caused by a vascular burden as well as insidious neurodegenerative changes. Neuroimaging determinants of dementia after stroke include silent brain infarcts, white matter changes, lacunar infarcts and medial temporal lobe atrophy. Published clinical trials have not been promising and there is little information on whether PSD can be prevented using pharmacological agents. Control of vascular disease risk and prevention of recurrent strokes are key to reducing the burden of cognitive decline and post-stroke dementia. Modern imaging and analysis techniques will help to elucidate the mechanism of PSD and establish better treatment. PMID:27395459

  3. Delayed post-conditioning reduces post-ischemic glutamate level and improves protein synthesis in brain.

    PubMed

    Bonova, Petra; Burda, Jozef; Danielisova, Viera; Nemethova, Miroslava; Gottlieb, Miroslav

    2013-05-01

    In the clinic delayed post-conditioning would represent an attractive strategy for the survival of vulnerable neurons after an ischemic event. In this paper we studied the impact of ischemia and delayed post-conditioning on blood and brain tissue concentrations of glutamate and protein synthesis. We designed two groups of animals for analysis of brain tissues and blood after global ischemia and post-conditioning, and one for analysis of blood glutamate after transient focal ischemia. Our results showed elevated blood glutamate in two models of transient brain ischemia and decreases in blood glutamate to control in the first 20min of post-conditioning recirculation followed by a consecutive drop of about 20.5% on the first day. Similarly, we recorded reduced protein synthesis in hippocampus and cortex 2 and 3days after ischemia. However, increased glutamate was registered only in the hippocampus. Post-conditioning improves protein synthesis in CA1 and dentate gyrus and, surprisingly, leads to 50% reduction in glutamate in whole hippocampus and cortex. In conclusion, ischemia leads to meaningful elevation of blood and tissue glutamate. Post-conditioning activates mechanisms resulting in rapid elimination of glutamate from brain tissue and/or in the circulatory system that could otherwise impede brain-to-blood glutamate efflux mechanisms. Moreover, post-conditioning induces protein synthesis renewing in ischemia affected tissues that could also contribute to elimination of excitotoxicity. In addition, the potential of glutamate for monitoring the progress of ischemia and efficacy of therapy was shown.

  4. Dental fiber-post resin base material: a review

    PubMed Central

    Xu, Chun; Zhang, Fu-qiang

    2014-01-01

    Teeth that have short clinical crown, which are not alone enough to support the definitive restoration can be best treated using the post and core system. The advantages of fiber post over conventional metallic post materials have led to its wide acceptance. In addition to that the combination of aesthetic and mechanical benefits of fiber post has provided it with a rise in the field of dentistry. Also the results obtained from some clinical trials have encouraged the clinicians to use the fiber posts confidently. Fiber posts are manufactured from pre-stretched fibers impregnated within a resin matrix. The fibers could that be of carbon, glass/silica, and quartz, whereas Epoxy and bis-GMA are the most widely used resin bases. But recently studies are also found to be going on for polyimide as possible material for the fiber post resin base as a substitute for the conventional materials. PMID:24605208

  5. Post-traumatic vertigo.

    PubMed

    Friedman, Jules M

    2004-10-01

    The vestibular-like symptoms that commonly follow head injury are most often due to one of a number of specific pathologies affecting vestibular, CNS or cervical structures. These pathologies can be readily identified in the majority of cases by appropriate testing in the examining room, and in vestibular function or neurodiagnosic laboratories. Whereas vestibular suppressants have a roll, they often delay recovery and have been supplanted as the mainstay of treatment in most cases by vestibular rehabilitation techniques. Given the large number of patients requiring outpatient management following head injury, it is appropriate that most generalists and many subspecialists should be aware of the differential diagnosis, workup and treatment options for post-traumatic vertigo.

  6. 40 CFR 264.117 - Post-closure care and use of property.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Post-closure care and use of property... FACILITIES Closure and Post-Closure § 264.117 Post-closure care and use of property. (a)(1) Post-closure care... and the environment (e.g., leachate or ground-water monitoring results, characteristics of...

  7. Preliminary neural response telemetry results.

    PubMed

    Cullington, H

    2000-06-01

    This paper describes the neural response telemetry (NRT) results obtained from the first 30 patients tested at this centre. One hundred per cent of patients tested intra-operatively had NRT responses on at least one electrode; this compared to 82.4% of patients tested post-operatively. Reasonable correlations existed between post-operative NRT thresholds and psychophysical threshold and comfort levels, although there was too much variability for the data to be used to set these parameters directly. Post-operative NRT thresholds were always at levels audible to patients.

  8. NEWS: Post-16 update

    NASA Astrophysics Data System (ADS)

    Campbell, Peter

    2000-07-01

    post16.gif As a teacher of physics it is very easy to become preoccupied with particulars of courses, or topics or even single concepts. Concerned with imminent student audiences and desired learning outcomes, the daily challenge is to summon satisfactory teaching approaches and resources for the job at hand. For the conscientious teacher, assessment outcomes may too often seem a judgment on our own efforts rather than those of our students. From time to time we may step back and think bigger, for example while planning a recruitment event, or while away from work on holiday. We may be successful locally. But why, at a time when books and television documentaries popularizing science have a large following, has physics education been facing declining numbers? Many recognize that physics has an essential contribution to make to the training of science or engineering specialists, but we know that it is also important for the skilled worker, the informed citizen and, in fact, for anyone trying to make sense of the world. So what are the best ways forward for post-16 physics? To make any impact on the bigger picture requires organization, thinking and meeting time among people in diverse roles: teachers and curriculum managers; university lecturers; employers and professional bodies; unitary awarding bodies; regulatory and funding agencies; and even Government. For the past few years, the Institute of Physics post-16 Initiative has created an unrivalled opportunity to address the wider issues. Its Shaping the Future booklets series was designed to stimulate informed discussion and debate, by providing background information and analysis. Taken together, the booklets should help all those concerned with physics education to understand where we are now, and why. Literally dozens of people have contributed to a review and analysis of physics education. Each booklet is a 48-page smorgasbord in A4 landscape format, containing many examples of good practice, basic but

  9. IVGEN Post Flight Analysis

    NASA Technical Reports Server (NTRS)

    Mcquillen, John; Brown, Dan; Hussey, Sam; Zoldak, John

    2014-01-01

    The Intravenous Fluid Generation (IVGEN) Experiment was a technology demonstration experiment that purified ISS potable water, mixed it with salt, and transferred it through a sterilizing filter. On-orbit performance was verified as appropriate and two 1.5 l bags of normal saline solution were returned to earth for post-flight testing by a FDA certified laboratory for compliance with United States Pharmacopiea (USP) standards. Salt concentration deviated from required values and an analysis identified probable causes. Current efforts are focused on Total Organic Content (TOC) testing, and shelf life.The Intravenous Fluid Generation (IVGEN) Experiment demonstrated the purification of ISS potable water, the mixing of the purified water with sodium chloride, and sterilization of the solution via membrane filtration. On-orbit performance was monitored where feasible and two 1.5-liter bags of normal saline solution were returned to earth for post-flight testing by a FDA-registered laboratory for compliance with United States Pharmacopeia (USP)standards [1]. Current efforts have been focused on challenge testing with identified [2] impurities (total organic-carbon), and shelf life testing. The challenge testing flowed known concentrations of contaminants through the IVGEN deionizing cartridge and membrane filters to test their effectiveness. One finding was that the filters and DI-resin themselves contribute to the contaminant load during initial startup, suggesting that the first 100 ml of fluid be discarded. Shelf life testing is ongoing and involves periodic testing of stored DI cartridges and membrane filters that are capped and sealed in hermetic packages. The testing is conducted at six month intervals measuring conductivity and endotoxins in the effluent. Currently, the packaging technique has been successfully demonstrated for one year of storage testing. The USP standards specifies that the TOC be conducted at point of generation as opposed to point of

  10. Root dentin strain and temperature rise during endodontic treatment and post rehabilitation.

    PubMed

    Amade, Euridsse Sulemane; Novais, Veridiana Resende; Roscoe, Marina Guimarães; Azevedo, Fabiane Maria Ferreira; Bicalho, Aline Aredes; Soares, Carlos José

    2013-01-01

    This study investigated the effects of endodontic treatment procedures and different post systems rehabilitation steps on the strain and temperature rise on apical and cervical root dentin regions. Twenty-one extracted human canine teeth had two strain gages attached to the distal root surface and two thermocouples attached to the mesial root surface (cervical and apical). The strain and temperature rise were recorded during the following procedures: root canal preparation, final rinse and drying, root canal filling and canal relief. Then the teeth were divided into three groups (n=7), according to the type of post system: CPC, cast post and core; FGP, fiberglass post; and PSP, prefabricated steel post. Data continued to be recorded during the post space preparation, post modeling (only for CPC), post trying and post cementation. Data were subjected to a two-way ANOVA followed by Tukey's test (α=0.05). The post-space preparation caused the highest temperature rise (4.0-14.9 °C) and the highest strain in the apical region during irrespective of post type. The resin cement light-activation resulted in significant temperature increases in the cervical region for all of the groups. The canal relief and the post-space preparation produced highest temperature rises. The CPC post modeling resulted in higher root strain level similarly the level of post preparation. The PSP resulted in highest strain during post trying and post cementation. PMID:24474355

  11. Root dentin strain and temperature rise during endodontic treatment and post rehabilitation.

    PubMed

    Amade, Euridsse Sulemane; Novais, Veridiana Resende; Roscoe, Marina Guimarães; Azevedo, Fabiane Maria Ferreira; Bicalho, Aline Aredes; Soares, Carlos José

    2013-01-01

    This study investigated the effects of endodontic treatment procedures and different post systems rehabilitation steps on the strain and temperature rise on apical and cervical root dentin regions. Twenty-one extracted human canine teeth had two strain gages attached to the distal root surface and two thermocouples attached to the mesial root surface (cervical and apical). The strain and temperature rise were recorded during the following procedures: root canal preparation, final rinse and drying, root canal filling and canal relief. Then the teeth were divided into three groups (n=7), according to the type of post system: CPC, cast post and core; FGP, fiberglass post; and PSP, prefabricated steel post. Data continued to be recorded during the post space preparation, post modeling (only for CPC), post trying and post cementation. Data were subjected to a two-way ANOVA followed by Tukey's test (α=0.05). The post-space preparation caused the highest temperature rise (4.0-14.9 °C) and the highest strain in the apical region during irrespective of post type. The resin cement light-activation resulted in significant temperature increases in the cervical region for all of the groups. The canal relief and the post-space preparation produced highest temperature rises. The CPC post modeling resulted in higher root strain level similarly the level of post preparation. The PSP resulted in highest strain during post trying and post cementation.

  12. Comparative evaluation of retention of prefabricated and conventional cast post: An in vitro study

    PubMed Central

    Choudhary, Suchismita; Begum, Zubeda; Choudhary, Prashant; Tripathi, Siddhi

    2014-01-01

    Background and Objectives: This study was conducted to evaluate the retention of various prefabricated posts and to compare them with that of the conventional cast post. Materials and Methods: A sample of 60 freshly extracted single-rooted human mandibular first premolars were sectioned horizontally, 1 mm coronal to the cemento-enamel junction and randomly divided into four groups consisting of carbon fiber posts, glass fiber posts, stainless steel posts and cast metal posts. Cast metal post was the control group. Each group contained 15 specimen. The post space of 9 mm depth was prepared using specific drill supplied by the manufacturer. Resin patterns of the prepared post spaces were fabricated for 15 specimen and were cast in nickel chromium base metal alloy. All the posts were cemented with self-adhesive resin cement and mounted in acrylic cylinders. The teeth were subjected to tensile pull-out test using a universal testing machine. The force required to dislodge each post from the teeth was recorded. The data was analyzed using one-way analysis of variance and Bonferroni test. Results: The bond strength of all the prefabricated posts was significantly lower than the conventional cast post. Among the prefabricated posts highest bond strength was obtained for prefabricated stainless steel post and lowest for carbon fiber posts. There was no significant difference in the mean bond strength obtained for stainless steel and glass fiber post. Conclusion: Though no single prefabricated post could achieve results close to the control group, most retentive among the experimental group were the stainless steel posts. However, conditions where nonmetallic posts are indicated most preferred type of post can be the glass fiber posts. PMID:25254191

  13. Equine post-breeding endometritis: A review

    PubMed Central

    2008-01-01

    The deposition of semen, bacteria and debris in the uterus of the mare after breeding normally induces a self-limiting endometritis. The resultant fluid and inflammatory products are cleared by 48 hours post cover. Mares that are susceptible to persistent post-breeding endometritis (PPBEM) have impaired uterine defence and clearance mechanisms, making them unable to resolve this inflammation within the normal time. This persists beyond 48 hours post-breeding and causes persistent fluid accumulation within the uterus. Mares with PPBEM have an increased rate of embryonic loss and a lower overall pregnancy rate than those without the condition. To enhance conception rates, mares at high risk need optimal breeding management as well as early diagnosis, followed by the most appropriate treatment. This article reviews the pathogenesis, diagnosis and treatment of PPBEM and the management of affected mares. PMID:21851709

  14. Post-thoracotomy Pain Management Problems

    PubMed Central

    Gerner, Peter

    2008-01-01

    Synopsis Pain after thoracotomy is very severe, probably the most severe pain experienced after surgery. It is also unique as this pain state has multiple implications, including respiratory failure due to splinting; inability to clear secretions by effective coughing, with resulting pneumonia; and facilitation of the often incapacitating chronic pain: the post-thoracotomy pain syndrome. Thoracic epidural analgesia has greatly improved the pain experience and its consequences and has been considered the ‘gold standard’ for pain management after thoracotomy. This view has recently been challenged by the use of paravertebral nerve blocks. Nevertheless, severe ipsilateral shoulder pain and the prevention of the post-thoracotomy pain syndrome remain the most important challenges for post-thoracotomy pain management. PMID:18456219

  15. Welcome to the Post-Industrial Society

    ERIC Educational Resources Information Center

    Bell, Daniel

    1976-01-01

    Reports that the world is entering a post-industrialized state in which the chief raw product is information. Experimentation in which totally new products are formed is decreasing, being replaced by products which are synthesized from existing knowledge. Warns that the increase in scale that institutions and cities are encountering may result in…

  16. [POST MORTEM PATERNITY].

    PubMed

    Marguénaud, Jean-Pierre

    2015-07-01

    Post mortem paternity, namely the procreation after the death of the man whom is part of the couple, is one of the questions which raised the most hesitations since the first bioethics laws of 1994. The National Assembly, encouraged by several opinions of the CCNE (National advisory committee of ethics) had let itself convince that the transfer had, at least, to be authorized in utero embryos preserved at the regard of which no one could not claim to have rights equal or higher than those of the woman concerned. However, the Senate always ended up obtaining the maintenance of an absolute prohibition of posthumous procreation (starting) from the spermatozoids or frozen embryos. This indifference with the cruelty of the application of the law to the women plunged into mourning--based on a paradoxical appreciation of the interest of the child not to be born orphan, and on a not very glorious taking into account of the interest of the Body of notaries not to change its practices--is particularly debatable. One can, nevertheless, try to understand it according to the obsession of the legalization of surrogate motherhood by application of the principle of nondiscrimination which could justify the requests of the men who, thanks to a surrogate mother, would wish to become fathers starting from gametes or embryos taken or created before the death of their wife or partner. PMID:27356350

  17. NEWS: Post-16 update

    NASA Astrophysics Data System (ADS)

    Campbell, Peter

    2000-07-01

    post16.gif As a teacher of physics it is very easy to become preoccupied with particulars of courses, or topics or even single concepts. Concerned with imminent student audiences and desired learning outcomes, the daily challenge is to summon satisfactory teaching approaches and resources for the job at hand. For the conscientious teacher, assessment outcomes may too often seem a judgment on our own efforts rather than those of our students. From time to time we may step back and think bigger, for example while planning a recruitment event, or while away from work on holiday. We may be successful locally. But why, at a time when books and television documentaries popularizing science have a large following, has physics education been facing declining numbers? Many recognize that physics has an essential contribution to make to the training of science or engineering specialists, but we know that it is also important for the skilled worker, the informed citizen and, in fact, for anyone trying to make sense of the world. So what are the best ways forward for post-16 physics? To make any impact on the bigger picture requires organization, thinking and meeting time among people in diverse roles: teachers and curriculum managers; university lecturers; employers and professional bodies; unitary awarding bodies; regulatory and funding agencies; and even Government. For the past few years, the Institute of Physics post-16 Initiative has created an unrivalled opportunity to address the wider issues. Its Shaping the Future booklets series was designed to stimulate informed discussion and debate, by providing background information and analysis. Taken together, the booklets should help all those concerned with physics education to understand where we are now, and why. Literally dozens of people have contributed to a review and analysis of physics education. Each booklet is a 48-page smorgasbord in A4 landscape format, containing many examples of good practice, basic but

  18. Recovery post ICU.

    PubMed

    Jones, Christina

    2014-10-01

    Many ICU patients struggle to recovery following critical illness and may be left with physical, cognitive and psychological problems, which have a negative impact on their quality of life. Gross muscle mass loss and weakness can take some months to recover after the patients' Intensive Care Unit (ICU) discharge, in addition critical illness polyneuropathies can further complicate physical recovery. Psychological problems such as anxiety, depression and post traumatic stress disorder (PTSD) are common and have an negative impact on the patients' ability to engage in rehabilitation after ICU discharge. Finally cognitive deficit affecting memory can be a significant problem. The first step in helping patients to recover from such a devastating illness is to recognise those who have the greatest need and target interventions. Research now suggests that there are interventions that can accelerate physical recovery and reduce the incidence of psychological problems such as anxiety, depression and PTSD. Cognitive rehabilitation, however, is still in its infancy. This review will look at the research into patients' recovery and what can be done to improve this where needed.

  19. Rigidity and retention of ceramic root canal posts.

    PubMed

    Purton, D G; Love, R M; Chandler, N P

    2000-01-01

    Ceramic root-canal posts offer potential advantages over other types with respect to aesthetics and biocompatibility. Any post must be sufficiently rigid and retentive to withstand functional forces. Ceraposts (1.2 mm coronal diameter, ceramic, tapering, smooth posts) and Paraposts (1.25 mm, stainless-steel, parallel, serrated posts) were tested for rigidity by means of a three-point bending test. To test retention in roots, ceramic posts were cemented using one of three protocols: (1) glass-ionomer cement, (2) silane coupling agent and resin cement, or (3) sandblasted post surface, silane coupling agent, and resin cement. Stainless-steel posts were cemented with resin. The tensile force required to dislodge the posts, following four weeks of storage in water, was recorded. Data were compared using Student's t-test and Mann-Whitney U analysis. Ceraposts were significantly more rigid than Paraposts (p < 0.001). Paraposts cemented with resin were significantly more strongly retained than Ceraposts following any cementation protocol (p < 0.001). Retention of the ceramic posts was significantly greater with a silane coupling agent and resin cement than with glass-ionomer cement (p < 0.001). Sandblasting the ceramic posts produced variable results and needs further investigation before it could be recommended.

  20. Rigidity and retention of ceramic root canal posts.

    PubMed

    Purton, D G; Love, R M; Chandler, N P

    2000-01-01

    Ceramic root-canal posts offer potential advantages over other types with respect to aesthetics and biocompatibility. Any post must be sufficiently rigid and retentive to withstand functional forces. Ceraposts (1.2 mm coronal diameter, ceramic, tapering, smooth posts) and Paraposts (1.25 mm, stainless-steel, parallel, serrated posts) were tested for rigidity by means of a three-point bending test. To test retention in roots, ceramic posts were cemented using one of three protocols: (1) glass-ionomer cement, (2) silane coupling agent and resin cement, or (3) sandblasted post surface, silane coupling agent, and resin cement. Stainless-steel posts were cemented with resin. The tensile force required to dislodge the posts, following four weeks of storage in water, was recorded. Data were compared using Student's t-test and Mann-Whitney U analysis. Ceraposts were significantly more rigid than Paraposts (p < 0.001). Paraposts cemented with resin were significantly more strongly retained than Ceraposts following any cementation protocol (p < 0.001). Retention of the ceramic posts was significantly greater with a silane coupling agent and resin cement than with glass-ionomer cement (p < 0.001). Sandblasting the ceramic posts produced variable results and needs further investigation before it could be recommended. PMID:11203820

  1. An Eye More Fantastical: Frank Barron. Research Monograph No. 3.

    ERIC Educational Resources Information Center

    Barron, Frank

    In this monograph, the author presents a thesis that a genuine, pervasive innocence of perception underlies mature productive originality, and that it is based upon progression from the sense of awe and wonder and the natural spontaneity of childhood into integrated adult functioning with fine command of ways and means acquired through discipline…

  2. Distinguishing between Realistic and Fantastical Figures in Iran

    ERIC Educational Resources Information Center

    Davoodi, Telli; Corriveau, Kathleen H.; Harris, Paul L.

    2016-01-01

    Children in the United States come to distinguish historical from fictional story figures between the ages of 3 and 5 years, guided by the plausibility of the story events surrounding the figure (Corriveau, Kim, Schwalen, & Harris, 2009; Woolley & Cox, 2007). However, U.S. children vary in their reactions to stories that include…

  3. The Fantastic Facilitator: Engaging Activities for Leading Groups.

    ERIC Educational Resources Information Center

    Duttweiler, Patricia Cloud

    This document is designed to help facilitators with the formation and development of effective teams of people who have no previous history as a team and no training in group processes. Part 1 provides a narrative explanation of the stages of group development (investing in membership, forming attachments to subgroups, confronting/debating issues,…

  4. Networking the Light Fantastic--CD-ROMs on LANs.

    ERIC Educational Resources Information Center

    Kittle, Paul W.

    1992-01-01

    Describes the development of a local area network (LAN) at Loma Linda University that allows remote access for both IBM and Macintosh microcomputers to CD-ROMs. Topics discussed include types of networks; fiber optic technology; networking CD-ROM drives; remote access; modems; CD-ROM databases; memory management; interface software; and future…

  5. Four Fantastic Foods to Keep Your Eyes Healthy

    MedlinePlus

    ... Uveitis Focus On Pediatric Ophthalmology Education Center Oculofacial Plastic Surgery Center Laser Surgery Education Center Redmond Ethics ... Uveitis Focus On Pediatric Ophthalmology Education Center Oculofacial Plastic Surgery Center Laser Surgery Education Center Redmond Ethics ...

  6. Science Crafts for Kids: 50 Fantastic Things To Invent & Create.

    ERIC Educational Resources Information Center

    Diehn, Gwen; Krautwurst, Terry

    This resource book provides 48 science crafts that involve children in creative and inventive learning experiences. The opening chapter focuses on the construction of a science log that will be used in the colorfully illustrated activities that follow. Four broad topics provide the organization for the text: (1) Earth; (2) Air; (3) Water; and (4)…

  7. Brookhaven Lecture Series: Using the light fantastic: Number 211

    SciTech Connect

    Williams, G.

    1985-01-16

    The National Synchrotron Light Source is described, along with the principles of its operation, the properties of its radiation, and some perspective on what research can be done with the radiation. (LEW)

  8. Managing your gas processing plant: Fundamentalist, fashionable, farsighted or fantastic!

    SciTech Connect

    Neumann, R.W.

    1999-07-01

    The challenges facing the gas processing industry have motivated managers to consider a variety of interesting new initiatives in managing a gas processing business. Using direct industry experience and a brief survey of participating companies, the author reviews the state of five popular programs that have become common cornerstones of many optimization and reengineering efforts in the gas processing business. Several lesser initiatives are also briefly discussed. The five major programs are: Maintenance Management, Field Information Handling, Work Process Optimization, Compensation Design, and Procurement Optimization. The success of these programs and initiatives depends greatly on the company culture in which they are implemented. Critical success factors and pitfalls are discussed for each program. Particular attention is paid to practical considerations that undermine idealistic theory. The conclusion is that the future belongs to the Farsighted, who will be able to mix equal parts of vision, intelligence, common sense, understanding of both human nature and the processing business, execution and determination into a formidable formula for success in the new world of gathering and processing.

  9. A Fantastic Decomposition: Unsettling the Fury of Having to Wait

    ERIC Educational Resources Information Center

    Holmes, Rachel

    2012-01-01

    This article draws on data from a single element of a larger project, which focused on the issue of "how children develop a reputation as "naughty" in the early years classroom." The author draws attention to the (in)corporeal (re)formation of the line in school, undertaking a decomposition of the topological spaces of research/art/education. She…

  10. Distance Psychology Help: Fantastic, Reality or Unavoidable addition to Healthcare

    NASA Astrophysics Data System (ADS)

    Jordanova, M.; Dachev, T.; Vasileva, L.; Rasheva, M.

    The convergence of electronic equipment and therapeutic communication is termed tele-psychology Its applications have the potential to advance the fields of psychology in a multitude of ways as they are used when face-to-face contact with licensed psychologist is impossible Securing psychological consultations and help during long lasting flights such as human missions to Mars is unavoidable task The aim of our paper is to reveal the pros cons and overall effectiveness of tele-psychology as well as the potential expectations of those who are looking for and receive psychological help in virtual space The stress is on off-line psychological help that will be the only solution during long lasting flights The paper is based on ongoing project OHN 1514 2005 funded by National Science Fund Bulgaria The project has to illuminate the potential for virtual psychological work and to share our evolving understanding of what is truly possible despite the prevalent myths which shape our thinking

  11. Post-16 Science in England

    ERIC Educational Resources Information Center

    Swinscoe, David

    2012-01-01

    Science education at post-16 has had a high profile recently. Increasing the quality and quantity of STEM education is seen as a route to economic prosperity for both the individual and the nation. The post-16 sector is being encouraged to produce more STEM undergraduates and more STEM-skilled entrants to the industry with an emphasis on…

  12. Post-Baccalaureate Fellowship Program.

    ERIC Educational Resources Information Center

    Cadbury, Jr., William E.

    The Post-Baccalaureate Fellowship Program provides an opportunity for students who went to college with inferior preparation to supplement their education by studying for 1 year at an academically demanding liberal arts college before entering graduate or professional school. The post-baccalaureate fellows take regular courses in a program that is…

  13. Post-16 update

    NASA Astrophysics Data System (ADS)

    1999-11-01

    (Post-16 Initiative) Engineering Physics? Many A-level physics students do not go on to study physics. For them physics is a support subject, either just for fun or just for the grade. Where physics is a lead subject some students go on to study physics but many more go on to study engineering. So can we deliberately give some aspects of an A-level course an engineering flavour? Electromagnetism would seem a good place to start. There is a clear `physics' route into this topic, a microscopic forces and fields view of the situation. But do our students really need to look at it this way? All electromagnetic machines are linked magnetic and electric circuits. The design idea is to link these circuits as closely as possible. The electric circuits must be as good as possible, with a high conductivity. The magnetic circuits must be as good as possible, with high permeance. Conductivity depends on area/length. So does permeance. The goodness of an electromagnetic machine (how good it is at its job, which is linking electric and magnetic circuits) scales as the square of its linear dimensions. That means small electromagnetic machines are harder to make, and so the very smallest nanomotors are electrostatic. None of this is new, but many teachers are uncomfortable with it. We are thinking like physicists. Many of our students are not. They deserve us to take the trouble every now and again to encourage them to think a bit differently about a topic, to look at practical ways of discussing design and to give their course an engineering flavour. Philip Britton Coursework in A-level Physics The criteria for the new AS and A-levels have provided the teams developing the specifications with an opportunity to think creatively about how internal assessment is used within post-16 physics courses. Teachers may be concerned that allowing 30% of the marks to be internally assessed will create a burden for them. However, it is possible to look at this in a much more positive light

  14. NEWS: Post-16 update

    NASA Astrophysics Data System (ADS)

    1999-05-01

    (post16) Making physics connect Doesn't Melvyn Bragg do a wonderful job, engaging both scientists and artists in sensitive discussion on Radio 4 about their methods and their purposes? But every week teachers have the chance to show their students that physics is a way of seeing the world that is well-connected with other aspects of knowledge and culture. The stakes are high: students who fail to appreciate this generally choose not to study the subject beyond GCSE. Most students find our preoccupation with technical detail off-putting. Accepting that we have a syllabus to cover, it's still a question of balance. In our teaching we should aim for variety in order to find ways to connect with every student's interests. Also, we can show that we (the nearest embodiment of a physicist some students will experience) are multidimensional and so fully human. Most important, teachers need flexibility to both encourage and respond to student comment and questions. The first booklet in the discussion series Shaping the Future takes up these themes. Rich in ideas for both immediate use and the longer term, it aims to stimulate debate and improve teaching. Copies cost £5.50 including postage and are available from Ingrid Ebeyer, Post-16 Initiative, Institute of Physics, 76 Portland Place, London W1N 3DH. How far is it? This question is asked in many family cars and school minibuses at the start of a journey, and answered by most in terms of hours and minutes rather than miles. What a good idea for introducing a social and historical perspective to a lesson on distance, velocity and time. How far can you actually get in a day? What is the range of human activity? Walking for eight hours will get many people about 25 miles. A pack horse will progress at much the same rate, but fast riding or a coach and team of horses will get further. Motorway driving (when the cones are on holiday) would take you nearly 500 miles. The 05.15 am train from Penzance arrives in Inverness at 7

  15. Flow-induced vibration of the SSME LOX posts

    SciTech Connect

    Chen, S.S.; Jendrzejczyk, J.A.

    1986-01-01

    Cracking of liquid-oxygen (LOX) posts was observed in several evaluation tests. The design modification consists of attaching impingement shields to LOX posts in the upstream row. This has improved the vibration/fatigue problem of LOX posts. However, that modification results in an increased pressure drop that ultimately affects the lifetime of other components. This paper presents a preliminary assessment of the LOX post vibration problem including a review of relevant parameters, flow induced vibration mechanisms, and scoping calculation and experiment. 11 refs.

  16. Post and a random-walk search mode

    NASA Technical Reports Server (NTRS)

    Martin, J. A.

    1984-01-01

    Multidisciplinary analysis often requires optimization of nonlinear systems that are subject to constraints. Trajectory optimization is one example of this situation. The Program to Optimize Simulated Trajectories (POST) was used successfully for a number of problems. The purpose is to describe POST and a new optimization approach that has been incorporated into it. Typical uses of POST will also be illustrated. The projected-gradient approach to optimization is the preferred option in POST and is discussed. A new approach to optimization, the random-walk approach, is described, and results with the random-walk approach are presented.

  17. Post-combustion reactions and modeling

    NASA Astrophysics Data System (ADS)

    Story, Scott R.

    Owing to the presence of carbon, oxygen and hydrogen in many iron and steelmaking processes, vast quantities of combustible gases rich in CO along with Hsb2 are often created. To take advantage this potential chemical energy, extra amounts of oxygen may be supplied to the process in order to combust these species, through a practice known as post combustion. Effective post combustion is important in many steelmaking processes. Post combustion is strongly affected by fluid flow. However, in the presence of carbon and iron at high temperatures reactions known as "de-postcombustion" occur where carbon or Fe is oxidised. These reactions depend on kinetics and fluid flow. To address the lack of information at high temperature, the kinetics of carbon oxidation by COsb2 and Hsb2O has been studied at temperatures between 1300sp° C and 1500sp° C. At 1500sp° C, the graphite-Hsb2O reaction was found to occur at a similar rate to the graphite-COsb2 reaction. The overriding importance of internal pore structure was demonstrated in the results, particularly as it develops in the reacted layer during the course of the reaction. Such changes are believed to be responsible for the continuous rate increase observed in non-porous glassy carbon and the consistently higher rates measured in graphite than in coke at high temperatures. The results of this work have also been used to clarify the role of the gas-carbon reaction in the kinetics of FeO reduction in bath smelting slags by solid carbon. Under high stirring conditions in the slag it has been found that the gas-carbon reaction may play a significant role, particularly when coke is the carbonaceous material. The second component of this study was directed toward understanding the effect of fluid flow on post combustion in the electric arc furnace (EAF). In particular the objective was to determine if computational fluid dynamics (CFD) can be a useful tool for optimising post combustion. The post combustion degree (PCD) was

  18. Effects of post surface conditioning before silanization on bond strength between fiber post and resin cement

    PubMed Central

    Ranjbarian, Parisa

    2013-01-01

    PURPOSE Post surface conditioning is necessary to expose the glass fibers to enable bonding between fiber post and resin cement. The purpose of the present study was to evaluate the effect of different surface conditioning on tensile bond strength (TBS) of a glass fiber reinforced post to resin cement. MATERIALS AND METHODS In this in vitro study, 40 extracted single canal central incisors were endodontically treated and post spaces were prepared. The teeth were divided into four groups according to the methods of post surface treatment (n=10): 1) Silanization after etching with 20% H2O2, 2) Silanization after airborne-particle abrasion, 3) Silanization, and 4) No conditioning (Control). Adhesive resin cement (Panavia F 2.0) was used for cementation of the fiber posts to the root canal dentin. Three slices of 3 mm thick were obtained from each root. A universal testing machine was used with a cross-head speed of 1 mm/minute for performing the push-out tests. Two-way ANOVA and Tukey post hoc tests were used for analyzing data (α=0.05). RESULTS It is revealed that different surface treatments and root dentin regions had significant effects on TBS, but the interaction between surface treatments and root canal regions had no significant effect on TBS. There was significant difference among H2O2 + Silane Group and other three groups. CONCLUSION There were significant differences among the mean TBS values of different surface treatments. Application of hydrogen peroxide before silanization increased the bond strength between resin cements and fiber posts. The mean TBS mean values was significantly greater in the coronal region of root canal than the middle and apical thirds. PMID:23755337

  19. Renal Dysfunction in Post-Stroke Patients

    PubMed Central

    Król, Ewa; Wierucki, Łukasz; Kozera, Grzegorz; Sobolewski, Piotr; Nyka, Walenty M.; Zdrojewski, Tomasz

    2016-01-01

    Background The presence of chronic kidney disease (CKD) is an indicator of a worse long-term prognosis in patients with ischemic stroke (IS). Unfortunately, not much is known about renal function in the population of post-IS subjects. The aim of our study was to assess the prevalence of renal damage and impaired renal function (IRF) in the population of post-IS subjects. Methods This prospective analysis concerned 352 consecutive post-IS survivors hospitalized in Pomeranian stroke centers (Poland) in 2009. In this group estimated glomerular filtration rate (eGFR) according to MDRD (modification of diet in renal diseases) and CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) formulas and urine albumin/creatinine ratio (ACR) were determined. Results Among survivors decreased eGFR (<60 mL/min./1.73m2 according to MDRD or CKD-EPI) or ACR≥30mg/g were detected in 40.38% (23.07% Men, 55.32% Women; P<0.01). The highest prevalence of IRF was noted in post-IS subjects with atheromatic and lacunar IS. In multivariate analysis the ACR≥30mg/g was predicted by older age, diabetes mellitus (DM) and physical disability (modified Rankin scale 3–5 pts.). The association with reduced eGFR was proved for sex (female), DM and physical disability. Conclusions CKD is a frequently occurring problem in the group of post-IS subjects, especially after lacunar and atheromatic IS. Post-IS patients, mainly the elderly women, with physical disability and diabetes mellitus, should be regularly screened for CKD. This could reduce the risk of further cardiovascular events and delay the progression of IRF. PMID:27575370

  20. Ex vivo fracture resistance of endodontically treated maxillary central incisors restored with fiber-reinforced composite posts and experimental dentin posts

    PubMed Central

    Kathuria, Ambica; Kavitha, M; Khetarpal, Suchit

    2011-01-01

    Aim: To compare the fracture resistance of teeth restored with fiber-reinforced composite (FRC) posts and experimental dentin posts milled from human root dentin. Materials and Methods: Thirty maxillary central incisors were divided into three groups of ten each. Twenty teeth were restored with FRC posts and solid dentin posts and numbered as Groups 2 and 3 respectively while Group 1 acted as the control, without any post. The teeth were loaded at 135° angle to their long axes after core build-up and the failure loads were recorded. Results: One-way Analysis of Variance (ANOVA) and Bonferroni multiple comparisons revealed a significant difference among test groups with the control group showing the highest fracture resistance, followed by the dentin post group and lastly the FRC post group. Conclusions: Teeth restored with dentin posts exhibited better fracture resistance than those restored with FRC posts. PMID:22144812

  1. Post-natal myogenic and adipogenic developmental

    PubMed Central

    Konings, Gonda; van Weeghel, Michel; van den Hoogenhof, Maarten MG; Gijbels, Marion; van Erk, Arie; Schoonderwoerd, Kees; van den Bosch, Bianca; Dahlmans, Vivian; Calis, Chantal; Houten, Sander M; Misteli, Tom

    2011-01-01

    A-type lamins are a major component of the nuclear lamina. Mutations in the LMNA gene, which encodes the A-type lamins A and C, cause a set of phenotypically diverse diseases collectively called laminopathies. While adult LMNA null mice show various symptoms typically associated with laminopathies, the effect of loss of lamin A/C on early post-natal development is poorly understood. Here we developed a novel LMNA null mouse (LMNAGT−/−) based on genetrap technology and analyzed its early post-natal development. We detect LMNA transcripts in heart, the outflow tract, dorsal aorta, liver and somites during early embryonic development. Loss of A-type lamins results in severe growth retardation and developmental defects of the heart, including impaired myocyte hypertrophy, skeletal muscle hypotrophy, decreased amounts of subcutaneous adipose tissue and impaired ex vivo adipogenic differentiation. These defects cause death at 2 to 3 weeks post partum associated with muscle weakness and metabolic complications, but without the occurrence of dilated cardiomyopathy or an obvious progeroid phenotype. Our results indicate that defective early post-natal development critically contributes to the disease phenotypes in adult laminopathies. PMID:21818413

  2. The End of Lifelong Learning: A Post-Human Condition?

    ERIC Educational Resources Information Center

    Edwards, Richard

    2010-01-01

    This article explores the significance of theories of the post-human for lifelong learning. Drawing upon the works of Karen Barad and Bruno Latour, it suggests that education has focused on the learning subject as a result of an a priori assumption of a separation of matter from meaning, the object from the subject. By contrast, a post-human…

  3. Students' Perspectives on Materials Posted on Faculty Office Doors

    ERIC Educational Resources Information Center

    Kelly, David B.

    2008-01-01

    Undergraduates (N = 459) completed a survey in which they rated the appropriateness of various materials that might be posted on the outside of faculty office doors. Results indicated that students considered school-related items to be the most appropriate for posting on faculty doors; items of personal expression were rated second most…

  4. Students and Social Networking Sites: The Posting Paradox

    ERIC Educational Resources Information Center

    Miller, Robert; Parsons, Kristine; Lifer, David

    2010-01-01

    This article reports the results of a field study in which undergraduate students were questioned about their use of social networking sites and the appropriateness of the content that they post. The responses indicate that students routinely post content that they realise is not appropriate for all audiences, especially potential employers.…

  5. 78 FR 2950 - Proposed Posting and Posting of Stockyards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-15

    ... posted the stockyards. On January 26, 2010, we published a notice in the Federal Register (75 FR 4039...., Unadilla, Georgia. IN-170 Tri-State Livestock Auction, LLC., Angola, Indiana. MS-177 Clark's...

  6. Effect of eugenol-containing sealer and post diameter on the retention of fiber reinforced composite posts

    PubMed Central

    Izadi, Alireza; Azarsina, Mohadese; Kasraei, Shahin

    2013-01-01

    Background: Fiber reinforced composite (FRC) posts are cemented with resin cements. It is reported that using resin cements in canals sealed with eugenol-containing sealers reduces the post retention. However, there is controversy on the subject. Aims: The aim was to investigate the influence of eugenol-containing sealers and the amount of dentin removal from root canal with different post diameters on retention of FRC posts. Settings and Design: It was an in vitro study Materials and Methods: The roots of sixty teeth were cut with 14 mm distance from the apex and were instrumented to the working-length of 13 mm. The teeth were randomly distributed into 2 groups (n = 30). Following storage in normal saline for 7 days, the samples in both the groups were further divided into 3 subgroups (n = 10). Canals in the experimental subgroups (I, II, III) were obturated by gutta-percha and eugenol-containing sealer; and in the control subgroups (IV, V, VI) without any sealer. After storage in normal saline for 7 days, the post space was prepared by #3, #2, and #1 drills of DT Light-Post system. Post was cemented with Panavia-F2.0 resin-cement. A composite core was built for each sample. All samples were thermo cycled for 1000 cycles. The samples were tested for post retention with a mechanical testing machine. Statistical Analysis: Data were analyzed by two-way ANOVA and Tukey-HSD test. Results: There was not a significant difference in retention between FRC posts #1 and #2 (P > 0.05). Post #3 was more retentive than posts #1and #2 (P < 0.05). ZOE sealer significantly reduced the retention of posts (P = 0.024), however, increasing post-space diameter significantly increased post retention in canals coated with ZOE sealer (P = 0.002). Conclusions: Eugenol-containing sealer reduced the retention of FRC posts cemented with resin cement. Removing more dentin from root-canals treated with eugenol-containing sealer for placing larger diameter posts caused an increase in post

  7. 32 CFR 643.120 - Post offices.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 4 2013-07-01 2013-07-01 false Post offices. 643.120 Section 643.120 National... Additional Authority of Commanders § 643.120 Post offices. Title 10 U.S.C. 4779b, provides that the SA shall assign suitable space for post office purposes at military posts where post offices have been...

  8. 32 CFR 643.120 - Post offices.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Post offices. 643.120 Section 643.120 National... Additional Authority of Commanders § 643.120 Post offices. Title 10 U.S.C. 4779b, provides that the SA shall assign suitable space for post office purposes at military posts where post offices have been...

  9. 32 CFR 643.120 - Post offices.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 4 2014-07-01 2013-07-01 true Post offices. 643.120 Section 643.120 National... Additional Authority of Commanders § 643.120 Post offices. Title 10 U.S.C. 4779b, provides that the SA shall assign suitable space for post office purposes at military posts where post offices have been...

  10. 32 CFR 643.120 - Post offices.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Post offices. 643.120 Section 643.120 National... Additional Authority of Commanders § 643.120 Post offices. Title 10 U.S.C. 4779b, provides that the SA shall assign suitable space for post office purposes at military posts where post offices have been...

  11. 32 CFR 643.120 - Post offices.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 4 2012-07-01 2011-07-01 true Post offices. 643.120 Section 643.120 National... Additional Authority of Commanders § 643.120 Post offices. Title 10 U.S.C. 4779b, provides that the SA shall assign suitable space for post office purposes at military posts where post offices have been...

  12. Post-Traumatic Stress Disorder

    MedlinePlus

    ... Physician September 01, 2000, http://www.aafp.org/afp/20000901/1035.html) Post-traumatic Stress Reactions Following ... Physician August 01, 1999, http://www.aafp.org/afp/990800ap/524.html) Written by familydoctor.org editorial ...

  13. 39 CFR 241.1 - Post offices.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... July 1 each year, post offices are classified by the Postmaster General based on the allowable postal...) Third Class. Post offices having 36 but less 190 revenue units. (4) Fourth Class. Post offices...

  14. 77 FR 48550 - Technicolor Creative Services, Post Production Feature Mastering Division Including On-Site...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ... related to post-production services for films. The initial investigation resulted in a negative... Employment and Training Administration Technicolor Creative Services, Post Production Feature Mastering... 23, 2012, a state workforce agent requested administrative reconsideration of the...

  15. Grip strength in post-stroke hemiplegia

    PubMed Central

    Park, Soohee; Park, Joo-Young

    2016-01-01

    [Purpose] This study was performed in order to investigate the grip strength of the unaffected hand of hemiplegic post-stroke patients. [Subjects] This study conducted on 83 hemiplegic post-stroke patients from May to August 2012. [Methods] This study was measured the mean grip strength of the unaffected hand of patients with hemiplegia and comparatively analyzed this with the mean normal grip strength. [Results] The grip strength of the unaffected hand of patients with hemiplegia was weaker compared to the of normal. [Conclusion] Patients with hemiplegia demonstrated problems in both their unaffected and affected sides. Based on the results of this study, it is necessary to expand treatment from the affected to unaffected areas of patients with hemiplegia. PMID:27065562

  16. Post-16 update

    NASA Astrophysics Data System (ADS)

    1999-09-01

    Institute of Physics post-16 initiative, shaping the future Physics education based in IT - sorry ICT! Which, of course, makes for a nifty headline, but as is so often the case with neat slogans, little else. Two formative questions: What, in another decade, will the government of the day call `What you lot should be doing with computers'? and What, of the many things that currently exercise our intellects, will there be anything special to say about in a decade, concerning the use of computers in the teaching of physics? Advancing Physics represents some attempts to come to grips with the second of the two questions above. The first is left to a higher wisdom. In thinking about learning, what can we do with the huge processing power, increasingly available in smaller and less obtrusive packages? What will we do that helps people learn physics, both tomorrow and in 2009? Here are a few suggestions based on development work so far. Wide, reliable and shared access to well ordered learning resources. We have created a CD-ROM, with versions for both student and teacher, that provides a wide range of resources. These do not teach, but do provide. A commitment to allowing a course to evolve and adapt. Electronic publication puts the costs into origination, and not into publication and distribution. A website allows for the community of users to contribute. E-mail networks support individuals and propagate good practice. You can create and explore your own microworlds. The interactive nature of models, and the crafted relationships between the models and the natural world give an insight into the creative imaginary worlds of the physicist. The unreasonable, but pleasurable, success of mathematics in describing the natural world can come to the fore. Measurements that were not possible before are now possible. What was previously indirect, and inaccessible, now becomes a direct measurement, making relationships transparent in new and fruitful ways. The dichotomy between

  17. PHMC post-NPH emergency response training

    SciTech Connect

    Conrads, T.J.

    1997-04-08

    This document describes post-Natural Phenomena Hazard (NPH) emergency response training that was provided to two teams of Project Hanford Management Contractors (PHMC) staff that will be used to assess potential structural damage that may occur as a result of a significant natural phenomena event. This training supports recent plans and procedures to use trained staff to inspect structures following an NPH event on the Hanford Site.

  18. Evaluation of Different Post Lengths’ Effect on Fracture Resistance of a Glass Fiber Post System

    PubMed Central

    Adanir, Necdet; Belli, Sema

    2008-01-01

    Objectives The purpose of this in vitro study was to evaluate the influence of different post lengths upon root fracture resistance. Methods 78 maxillary central teeth with similar dimensions were mounted in acrylic blocks with artificial silicone periodontal ligaments. Combinations of post lengths of 6 mm (shorter than 1/1 clinical crown length), 9 mm (1/1 clinical crown length), and 12 mm (longer than 1/1 clinical crown length) made up 6 different groups consisting of 13 teeth each. The glass fiber posts (Snowpost) were cemented with Super-Bond C&B and Panavia F luting cement. Composite-resin cores were made with Clearfil PhotoCore. The specimens were tested in a universal test machine. The testing machine applied controlled loads to the core, 2 mm from its incisal edge, on the palatal side at an angle 135 degrees to the long axis of the root. The testing machine was set at a crosshead speed of 5mm per minute. All samples were loaded until failure. Results There was no statistically significant difference between cements (P>.05). Posts shorter than clinical crown length, demonstrated root fracture under significantly lower loading forces (P<.05). Conclusion Usage of posts shorter than clinical crowns should be avoided to eliminate clinical failure. PMID:19212505

  19. 'The last post?': assessment of the failing post-retained crown.

    PubMed

    Beddis, Hannah P; Okechukwu, Nnaemeka; Nattress, Brian R

    2014-06-01

    Failure of a post-retained restoration can provide a challenge to the general dental practitioner (GDP) in terms of diagnosis, treatment planning and communication with the patient. The cause of failure must be identified, and a thorough assessment of the restoration, remaining tooth and its functional and aesthetic demands carried out in order to plan treatment to provide the most reliable result. Clinical Relevance: This article discusses the assessment of failing post-retained crowns, with discussion of reasons for failure, thereby assisting the GDP in decision-making and treatment planning for such teeth. PMID:25073219

  20. Research Results

    NASA Astrophysics Data System (ADS)

    2011-12-01

    Research on Global Carbon Emission and Sequestration NSFC Funded Project Made Significant Progress in Quantum Dynamics Functional Human Blood Protein Obtained from Rice How Giant Pandas Thrive on a Bamboo Diet New Evidence of Interpersonal Violence from 129,000 Years Ago Found in China Aptamer-Mediated Efficient Capture and Release of T Lymphocytes on Nanostructured Surfaces BGI Study Results on Resequencing 50 Accessions of Rice Cast New Light on Molecular Breeding BGI Reports Study Results on Frequent Mutation of Genes Encoding UMPP Components in Kidney Cancer Research on Habitat Shift Promoting Species Diversification

  1. A Novel Technique for Post-Prostatectomy Catheter Traction

    PubMed Central

    Akhavizadegan, Hamed

    2016-01-01

    Background Prostate traction is one way to control post-prostatectomy bleeding. The most popular method involves traction with a catheter fixed to the thigh with adhesive bands. However, this method has its own drawbacks. Objectives We aimed to simplify this traction procedure and to overcome its disadvantages. Patients and Methods From 2007 - 2015, a new method was used to control post-prostatectomy bleeding in 152 patients. This technique involved inducing pressure on the prostate neck with an indwelling catheter attached to a partially filled urine bag to control bleeding after a prostatectomy. Results The new method effectively controlled post-prostatectomy bleeding. A few patients required surgical intervention. Conclusions Post-prostatectomy catheter traction using a semi-filled urine bag was an acceptable alternative to the standard method to control post-operative bleeding. PMID:27703955

  2. Second post-Newtonian approximation of Einstein-aether theory

    SciTech Connect

    Xie Yi; Huang Tianyi

    2008-06-15

    In this paper, second post-Newtonian approximation of Einstein-aether theory is obtained by Chandrasekhar's approach. Five parametrized post-Newtonian parameters in first post-Newtonian approximation are presented after a time transformation and they are identical with previous works, in which {gamma}=1, {beta}=1, and two preferred-frame parameters remain. Meanwhile, in second post-Newtonian approximation, a parameter, which represents third order nonlinearity for gravity, is zero--the same as in general relativity. For an application for future deep space laser ranging missions, we reduce the metric coefficients for light propagation in a case of N point masses as a simplified model of the Solar System. The resulting light deflection angle in second post-Newtonian approximation poses another constraint on the Einstein-aether theory.

  3. [Post-stroke apathy].

    PubMed

    López-Dóriga Bonnardeaux, Pedro; Andrino Díaz, Nuria

    2016-01-01

    Apathy is a motivational disturbance that can be defined as a quantitative reduction of goal-directed behaviour. Patients present with loss of motivation, concern, interest, and emotional response, resulting in a loss of initiative, decreased interaction with their environment, and a reduced interest in social life. Apathy not only appears to be common in stroke patients, but it has also been related to a wide range of negative consequences for the patients and their caregivers, including poor functional recovery, loss of social independence, and caregiver distress. Clear definition and consensus diagnostic criteria for apathy are needed to accomplish an accurate assessment and an individualised treatment plan. Although there have been reports of successful behavioural therapy treatment of apathetic states, there is a paucity of controlled clinical trials on the efficacy of apathetic behaviours using pharmacotherapy. PMID:26522489

  4. Global Health Diplomacy, Monitoring & Evaluation, and the Importance of Quality Assurance & Control: Findings from NIMH Project Accept (HPTN 043): A Phase III Randomized Controlled Trial of Community Mobilization, Mobile Testing, Same-Day Results, and Post-Test Support for HIV in Sub-Saharan Africa and Thailand

    PubMed Central

    Kevany, Sebastian; Khumalo-Sakutukwa, Gertrude; Singh, Basant; Chingono, Alfred; Morin, Stephen

    2016-01-01

    Background Provision and scale-up of high quality, evidence-based services is essential for successful international HIV prevention interventions in order to generate and maintain intervention uptake, study integrity and participant trust, from both health service delivery and diplomatic perspectives. Methods We developed quality assurance (QAC) procedures to evaluate staff fidelity to a cluster-randomized trial of the NIMH Project Accept (HPTN 043) assessing the effectiveness of a community-based voluntary counseling and testing strategy. The intervention was comprised of three components—Mobile Voluntary Counseling and Testing (MVCT), Community Mobilization (CM) and Post-Test Support Services (PTSS). QAC procedures were based on standardized criteria, and were designed to assess both provider skills and adherence to the intervention protocol. Supervisors observed a random sample of 5% to 10% of sessions each month and evaluated staff against multiple criteria on scales of 1–5. A score of 5 indicated 100% adherence, 4 indicated 95% adherence, and 3 indicated 90% adherence. Scores below 3 were considered unsatisfactory, and protocol deviations were discussed with the respective staff. Results During the first year of the intervention, the mean scores of MVCT and CM staff across the 5 study sites were 4 (95% adherence) or greater and continued to improve over time. Mean QAC scores for the PTSS component were lower and displayed greater fluctuations. Challenges to PTSS staff were identified as coping with the wide range of activities in the PTSS component and the novelty of the PTSS process. QAC fluctuations for PTSS were also associated with new staff hires or changes in staff responsibilities. Through constant staff monitoring and support, by Year 2, QAC scores for PTSS activities had reached those of MVCT and CM. Conclusions The implementation of a large-sale, evidence based HIV intervention requires extensive QAC to ensure implementation effectiveness

  5. What about ex post facto

    SciTech Connect

    McKee, H.C.

    1992-07-01

    This note presents a legal question in an attempt to find an answer. The author hopes that some legal scholar can explain the principle of ex post facto in the US Constitution as it applies to some of the environmental laws. One of the major advantages of the Association is that it provides a forum for communication among members with different backgrounds and experience. An ex post facto law is one that is applied retroactively. Under such a law, a person could be punished for some act that violated a law passed after the act was committed, even though the act was legal when committed. The US Constitution prohibits such laws, as will be discussed later. States are also prohibited from enacting ex post facto laws.

  6. AGR-1 Post Irradiation Examination Final Report

    SciTech Connect

    Demkowicz, Paul Andrew

    2015-08-01

    The post-irradiation examination (PIE) of the Advanced Gas Reactor (AGR)-1 experiment was a multi-year, collaborative effort between Idaho National Laboratory (INL) and Oak Ridge National Laboratory (ORNL) to study the performance of UCO (uranium carbide, uranium oxide) tristructural isotropic (TRISO) coated particle fuel fabricated in the U.S. and irradiated at the Advanced Test Reactor at INL to a peak burnup of 19.6% fissions per initial metal atom. This work involved a broad array of experiments and analyses to evaluate the level of fission product retention by the fuel particles and compacts (both during irradiation and during post-irradiation heating tests to simulate reactor accident conditions), investigate the kernel and coating layer morphology evolution and the causes of coating failure, and explore the migration of fission products through the coating layers. The results have generally confirmed the excellent performance of the AGR-1 fuel, first indicated during the irradiation by the observation of zero TRISO coated particle failures out of 298,000 particles in the experiment. Overall release of fission products was determined by PIE to have been relatively low during the irradiation. A significant finding was the extremely low levels of cesium released through intact coatings. This was true both during the irradiation and during post-irradiation heating tests to temperatures as high as 1800°C. Post-irradiation safety test fuel performance was generally excellent. Silver release from the particles and compacts during irradiation was often very high. Extensive microanalysis of fuel particles was performed after irradiation and after high-temperature safety testing. The results of particle microanalysis indicate that the UCO fuel is effective at controlling the oxygen partial pressure within the particle and limiting kernel migration. Post-irradiation examination has provided the final body of data that speaks to the quality of the AGR-1 fuel, building

  7. Psychosocial Interventions Pre and Post Bariatric Surgery.

    PubMed

    Kalarchian, Melissa A; Marcus, Marsha D

    2015-11-01

    Despite positive results overall, a substantial number of patients experience poor long-term outcomes following bariatric surgery. One reason for variability in weight loss may be difficulty in making and sustaining changes in dietary intake and physical activity; post-surgery binge eating has also been associated with poorer weight outcomes. In this paper, we review available evidence on adjunctive psychosocial interventions for bariatric surgery patients. Although the literature is limited, evidence suggests that bariatric surgery patients may benefit from a comprehensive approach targeting diet, activity and psychological factors. We think the optimal time to initiate adjunctive intervention is after surgery, but before significant weight regain has occurred. Adaptive interventions incorporating advances in technology may prove to be effective for promoting behavioural self-management and psychosocial adjustment following bariatric surgery. For some patients, pharmacotherapy and reoperation may also play a role in a personalized approach to post-surgery care. PMID:26364715

  8. Towards a post-modern medicine.

    PubMed

    Dacher, E S

    1997-06-01

    Although there is general agreement that our current approach to health and healing is undergoing substantial change, there has been a lack of critical discussion regarding the extent, character and direction of change. It is important for us to articulate the values that we would like expressed in a reconfigured approach to health and healing, and to ensure that our efforts to initiate change are aligned with these values. An overview of Western history suggests that the post-modern world-view is characterized by four essential values: multidimensional realism, intentionality, holism and personal authenticity. Our current efforts to change the direction of health care have failed to produce fundamental change. This has resulted from the compelling influence of existing perspectives and the promotion of parochial, professional and institutional interests. To assure fundamental change, articulated values that are consistent with a post-modern world must be articulated, fostered and embedded into innovative programmes.

  9. Clinical evaluation of carbon fiber reinforced carbon endodontic post, glass fiber reinforced post with cast post and core: A one year comparative clinical study

    PubMed Central

    Preethi, GA; Kala, M

    2008-01-01

    Aim: Restoring endodontically treated teeth is one of the major treatments provided by the dental practitioner. Selection and proper use of restorative materials continues to be a source of frustration for many clinicians. There is controversy surrounding the most suitable choice of restorative material and the placement method that will result in the highest probability of successful treatment. This clinical study compares two different varieties of fiber posts and one cast post and core in terms of mobility of crown margin under finger pressure, recurrent caries detected at the crown margin, fracture of the restoration, fracture of the root and periapical and periodontal pathology requiring crown removal over the period of 12months as evaluated by clinical and radiographical examination. Materials and Methods: 30 root canal treated, single rooted maxillary anterior teeth of 25 patients in the age range of 18–60 years where a post retained crown was indicated were selected for the study between January 2007 and August 2007; and prepared in a standard clinical manner. It was divided into 3 groups of 10 teeth in each group. After post space preparation, the Carbon fiber and Glass fiber reinforced posts were cemented with Scotch bond multipurpose plus bonding agent and RelyX adhesive resin cement in the first and second groups respectively. The Cast post and cores were cemented with Zinc Phosphate cement in the third group. Following post- cementation, the preparation was further refined and a rubber base impression was taken for metal-ceramic crowns which was cemented with Zinc Phosphate cement. A baseline periapical radiograph was taken once each crown was cemented. All patients were evaluated after one week (baseline), 3 months, 6 months and one year for following characteristics mobility of crown margin under finger pressure, recurrent caries detected at the crown margin, fracture of the restoration, fracture of the root and periapical and periodontal pathology

  10. Stress distributions in maxillary central incisors restored with various types of post materials and designs.

    PubMed

    Madfa, A A; Kadir, M R Abdul; Kashani, J; Saidin, S; Sulaiman, E; Marhazlinda, J; Rahbari, R; Abdullah, B J J; Abdullah, H; Abu Kasim, N H

    2014-07-01

    Different dental post designs and materials affect the stability of restoration of a tooth. This study aimed to analyse and compare the stability of two shapes of dental posts (parallel-sided and tapered) made of five different materials (titanium, zirconia, carbon fibre and glass fibre) by investigating their stress transfer through the finite element (FE) method. Ten three-dimensional (3D) FE models of a maxillary central incisor restored with two different designs and five different materials were constructed. An oblique loading of 100 N was applied to each 3D model. Analyses along the centre of the post, the crown-cement/core and the post-cement/dentine interfaces were computed, and the means were calculated. One-way ANOVAs followed by post hoc tests were used to evaluate the effectiveness of the post materials and designs (p=0.05). For post designs, the tapered posts introduced significantly higher stress compared with the parallel-sided post (p<0.05), especially along the centre of the post. Of the materials, the highest level of stress was found for stainless steel, followed by zirconia, titanium, glass fibre and carbon fibre posts (p<0.05). The carbon and glass fibre posts reduced the stress distribution at the middle and apical part of the posts compared with the stainless steel, zirconia and titanium posts. The opposite results were observed at the crown-cement/core interface.

  11. Stress distributions in maxillary central incisors restored with various types of post materials and designs.

    PubMed

    Madfa, A A; Kadir, M R Abdul; Kashani, J; Saidin, S; Sulaiman, E; Marhazlinda, J; Rahbari, R; Abdullah, B J J; Abdullah, H; Abu Kasim, N H

    2014-07-01

    Different dental post designs and materials affect the stability of restoration of a tooth. This study aimed to analyse and compare the stability of two shapes of dental posts (parallel-sided and tapered) made of five different materials (titanium, zirconia, carbon fibre and glass fibre) by investigating their stress transfer through the finite element (FE) method. Ten three-dimensional (3D) FE models of a maxillary central incisor restored with two different designs and five different materials were constructed. An oblique loading of 100 N was applied to each 3D model. Analyses along the centre of the post, the crown-cement/core and the post-cement/dentine interfaces were computed, and the means were calculated. One-way ANOVAs followed by post hoc tests were used to evaluate the effectiveness of the post materials and designs (p=0.05). For post designs, the tapered posts introduced significantly higher stress compared with the parallel-sided post (p<0.05), especially along the centre of the post. Of the materials, the highest level of stress was found for stainless steel, followed by zirconia, titanium, glass fibre and carbon fibre posts (p<0.05). The carbon and glass fibre posts reduced the stress distribution at the middle and apical part of the posts compared with the stainless steel, zirconia and titanium posts. The opposite results were observed at the crown-cement/core interface. PMID:24834856

  12. Facilitating post traumatic growth

    PubMed Central

    Turner, de Sales; Cox, Helen

    2004-01-01

    Background Whilst negative responses to traumatic injury have been well documented in the literature, there is a small but growing body of work that identifies posttraumatic growth as a salient feature of this experience. We contribute to this discourse by reporting on the experiences of 13 individuals who were traumatically injured, had undergone extensive rehabilitation and were discharged from formal care. All participants were injured through involvement in a motor vehicle accident, with the exception of one, who was injured through falling off the roof of a house. Methods In this qualitative study, we used an audio-taped in-depth interview with each participant as the means of data collection. Interviews were transcribed verbatim and analysed thematically to determine the participants' unique perspectives on the experience of recovery from traumatic injury. In reporting the findings, all participants' were given a pseudonym to assure their anonymity. Results Most participants indicated that their involvement in a traumatic occurrence was a springboard for growth that enabled them to develop new perspectives on life and living. Conclusion There are a number of contributions that health providers may make to the recovery of individuals who have been traumatically injured to assist them to develop new views of vulnerability and strength, make changes in relationships, and facilitate philosophical, physical and spiritual growth. PMID:15248894

  13. Explosive signatures: Pre & post blast

    NASA Astrophysics Data System (ADS)

    Bernier, Evan Thomas

    Manuscripts 1 and 2 of this dissertation both involve the pre-blast detection of trace explosive material. The first manuscript explores the analysis of human hair as an indicator of exposure to explosives. Field analysis of hair for trace explosives is quick and non-invasive, and could prove to be a powerful linkage to physical evidence in the form of bulk explosive material. Individuals tested were involved in studies which required handling or close proximity to bulk high explosives such as TNT, PETN, and RDX. The second manuscript reports the results of research in the design and application of canine training aids for non-traditional, peroxide-based explosives. Organic peroxides such as triacetonetriperoxide (TATP) and hexamethylenetriperoxidediamine (HMTD) can be synthesized relatively easily with store-bought ingredients and have become popular improvised explosives with many terrorist groups. Due to the hazards of handling such sensitive compounds, this research established methods for preparing training aids which contained safe quantities of TATP and HMTD for use in imprinting canines with their characteristic odor. Manuscripts 3 and 4 of this dissertation focus on research conducted to characterize pipe bombs during and after an explosion (post-blast). Pipe bombs represent a large percentage of domestic devices encountered by law enforcement. The current project has involved the preparation and controlled explosion of over 90 pipe bombs of different configurations in order to obtain data on fragmentation patterns, fragment velocity, blast overpressure, and fragmentation distance. Physical data recorded from the collected fragments, such as mass, size, and thickness, was correlated with the relative power of the initial device. Manuscript 4 explores the microstructural analysis of select pipe bomb fragments. Shock-loading of the pipe steel led to plastic deformation and work hardening in the steel grain structure as evidenced by optical microscopy and

  14. Post-hepatectomy liver failure

    PubMed Central

    Kauffmann, Rondi

    2014-01-01

    Hepatectomies are among some of the most complex operative interventions performed. Mortality rates after major hepatectomy are as high as 30%, with post-hepatic liver failure (PHLF) representing the major source of morbidity and mortality. We present a review of PHLF, including the current definition, predictive factors, pre-operative risk assessment, techniques to prevent PHLF, identification and management. Despite great improvements in morbidity and mortality, liver surgery continues to demand excellent clinical judgement in selecting patients for surgery. Appropriate choice of pre-operative techniques to improve the functional liver remnant (FLR), fastidious surgical technique, and excellent post-operative management are essential to optimize patient outcomes. PMID:25392835

  15. 39 CFR 241.1 - Post offices.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Post offices. 241.1 Section 241.1 Postal Service... DISCONTINUANCE § 241.1 Post offices. Post Offices are established and maintained at locations deemed necessary to... geographic boundaries. A Post Office may be operated or staffed by a postmaster or by another type of...

  16. 39 CFR 241.1 - Post offices.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Post offices. 241.1 Section 241.1 Postal Service... DISCONTINUANCE § 241.1 Post offices. Post Offices are established and maintained at locations deemed necessary to... geographic boundaries. A Post Office may be operated or staffed by a postmaster or by another type of...

  17. 39 CFR 241.1 - Post offices.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Post offices. 241.1 Section 241.1 Postal Service... DISCONTINUANCE § 241.1 Post offices. (a) Establishment. Post Offices are established and maintained at locations... within specified geographic boundaries. A Post Office may be operated or staffed by a postmaster or...

  18. 49 CFR 1312.12 - Posting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Posting requirements. 1312.12 Section 1312.12..., POSTING AND FILING OF TARIFFS FOR THE TRANSPORTATION OF PROPERTY BY OR WITH A WATER CARRIER IN NONCONTIGUOUS DOMESTIC TRADE § 1312.12 Posting requirements. (a) General posting requirements. (1) Each...

  19. Post-hypoxic Myoclonus: Current Concepts, Neurophysiology, and Treatment

    PubMed Central

    Gupta, Harsh V.; Caviness, John N.

    2016-01-01

    Background Myoclonus may occur after hypoxia. In 1963, Lance and Adams described persistent myoclonus with other features after hypoxia. However, myoclonus occurring immediately after hypoxia may demonstrate different syndromic features from classic Lance–Adams syndrome (LAS). The aim of this review is to provide up-to-date information about the spectrum of myoclonus occurring after hypoxia with emphasis on neurophysiological features. Methods A literature search was performed on PubMed database from 1960 to 2015. The following search terms were used: “myoclonus,” “post anoxic myoclonus,” “post hypoxic myoclonus,” and “Lance Adams syndrome.” The articles describing clinical features, neurophysiology, management, and prognosis of post-hypoxic myoclonus cases were included for review. Results Several reports in the literature were separated clinically into “acute post-hypoxic myoclonus,” which occurred within hours of severe hypoxia, and “chronic post-hypoxic myoclonus,” which occurred with some recovery of mental status as the LAS. Acute post-hypoxic myoclonus was generalized in the setting of coma. Chronic post-hypoxic myoclonus presented as multifocal cortical action myoclonus that was significantly disabling. There was overlap of neurophysiological findings for these two syndromes but also different features. Treatment options for these two distinct clinical–neurophysiologic post-hypoxic myoclonus syndromes were approached differently. Discussion The review of clinical and neurophysiological findings suggests that myoclonus after hypoxia manifests in one or a combination of distinct syndromes: acute and/or chronic myoclonus. The mechanism of post-hypoxic myoclonus may arise either from cortical and/or subcortical structures. More research is needed to clarify mechanisms and treatment of post-hypoxic myoclonus. PMID:27708982

  20. Nursing Process in Post Tonsillectomy Pain Diagnosis: A Systematic Review

    PubMed Central

    Soleymanifard, Fateme; Khademolhoseyni, Seyyed Mohamad; Nouri, Jamile Mokhtari

    2015-01-01

    Objective: Tonsillectomy is the most common surgery in the field of ENT. Pain is the most common post tonsillectomy complaint. Considering the importance of nursing cares in relieving post-surgery pain in general and post-tonsillectomy pain in particular, this study is conducted with the aim of presenting nursing process in post tonsillectomy pain diagnosis for decreasing loss of appropriate opportunities in nursing cares and achieving appropriate results in taking care of the patients. Methods: This study is a targeted systematic review focusing on “effective nursing measures in relieving children’s post tonsillectomy pain”. The main stages of searching strategy included searching in electronic sources of Latin databases; Pub Med, Science Direct, and EMBASE and Persian databases; SID, Iran medex, ISC to find published articles from 2009 to 2014. In the end, final synthesis was done on eight articles in English. Findings: Effective nursing measurements for relieving post tonsillectomy pain include: decreasing children’s anxiety through children and their families’ psychological preparation by nurses and other caregivers, using cold compress to reduce neck and jaw pain, presenting distraction techniques, offering fluids and cold foods immediately in the period after surgery, creating a comfortable environment for the children, avoiding too much of talking and adequate sleep. Conclusion: It is recommended to the nursing managers and nurses to perform cares achieved from this systematic review to achieve appropriate results in relieving post tonsillectomy pain. PMID:25560345

  1. Stress distribution of endodontically treated teeth with titanium alloy post and carbon fiber post with different alveolar bone height: A three-dimensional finite element analysis

    PubMed Central

    Singh, S. Vijay; Bhat, Manohar; Gupta, Saurabh; Sharma, Deepak; Satija, Harsha; Sharma, Sumeet

    2015-01-01

    Objective: A three-dimensional (3D) finite element analysis (FEA) on the stress distribution of endodontically treated teeth with titanium alloy post and carbon fiber post with different alveolar bone height. Materials and Methods: The 3D model was fabricated using software to represent an endodontically treated mandibular second premolar with post and restored with a full ceramic crown restoration, which was then analyzed using FEA using FEA ANSYS Workbench V13.0 (ANSYS Inc., Canonsburg, Pennsylvania, U.S.A) software. Results: The FEA showed the maximum stresses of 137.43 Mpa in dentin with alveolar bone height of 4 mm when the titanium post was used, 138.48 Mpa when carbon fiber post was used as compared to 105.91 Mpa in the model with alveolar bone height of 2 mm from the cement enamel junction (CEJ) when the titanium post was used and 107.37 Mpa when the carbon fiber post was used. Conclusions: Stress was observed more in alveolar bone height level of 4 mm from CEJ than 2 mm from CEJ. Stresses in the dentin were almost similar when the carbon fiber post was compared to titanium post. However, stresses in the post and the cement were much higher when titanium post was used as compared to carbon fiber post. PMID:26430375

  2. Retentive strength of different intracanal posts in restorations of anterior primary teeth: an in vitro study

    PubMed Central

    Memarpour, Mahtab; Abbaszadeh, Maryam

    2013-01-01

    Objectives To determine the retentive strength and failure mode of undercut composite post, glass fiber post and polyethylene fiber post luted with flowable composite resin and resin-cement. Materials and Methods Coronal parts of 120 primary canine teeth were sectioned and specimens were treated endodontically. The teeth were randomly divided into 6 groups (n = 20). Prepared root canals received intracanal retainers with a short composite post, undercut composite post, glass fiber post luted with flowable resin or resin-cement, and polyethylene fiber post luted with flowable resin or resin-cement. After crown reconstruction, samples were tested for retentive strength and failure mode. Statistical analysis was done with one-way ANOVA and Tukey tests (p < 0.05). Results There were statistically significant differences between groups (p = 0.001). Mean bond strength in the undercut group was significantly greater than in the short composite post (p = 0.030), and the glass fiber post (p = 0.001) and the polyethylene fiber post group luted with resin-cement (p = 0.008). However, the differences between the undercut group and the groups with flowable composite as the luting agent were not significant (p = 0.068, p = 0.557). Adhesive failure was more frequent in the fiber post groups. Conclusions Although the composite post with undercutting showed the greatest resistance to dislodgement, fiber posts cemented with flowable composite resin provided acceptable results in terms of retentive strength and fracture mode. PMID:24303356

  3. Structuralism, Post-Structuralism, and Neo-Liberalism: Assessing Foucault's Legacy.

    ERIC Educational Resources Information Center

    Olssen, Mark

    2003-01-01

    Traces Foucault's distinctive commitment to "post-structuralism." Argues that under the influence of Nietzsche, Foucault's approach marks a distinct break with structuralism in several crucial aspects. What results is a materialist post-structuralism that is also distinctively different from the post-structuralism of Derrida, Lyotard, and…

  4. Hydrogeological controls on post-fire moss recovery in peatlands

    NASA Astrophysics Data System (ADS)

    Lukenbach, M. C.; Devito, K. J.; Kettridge, N.; Petrone, R. M.; Waddington, J. M.

    2015-11-01

    Wildfire is the largest disturbance affecting boreal peatlands, however, little is known about the controls on post-fire peatland vegetation recovery. While small-scale variation in burn severity can reduce post-fire moss water availability, high water table (WT) positions following wildfire are also critical to enable the re-establishment of keystone peatland mosses (i.e. Sphagnum). Thus, post-fire moss water availability is also likely a function of landscape-scale controls on peatland WT dynamics, specifically, connectivity to groundwater flow systems (i.e. hydrogeological setting). For this reason, we assessed the interacting controls of hydrogeological setting and burn severity on post-fire moss water availability in three burned, Sphagnum-dominated peatlands in Alberta's Boreal Plains. At all sites, variation in burn severity resulted in a dichotomy between post-fire surface covers that: (1) exhibited low water availability, regardless of WT position, and had minimal (<5%) moss re-establishment (i.e. lightly burned feather mosses and severely burned Sphagnum fuscum) or (2) exhibited high water availability, depending on WT position, and had substantial (>50%) moss re-establishment (i.e. lightly burned S. fuscum and where depth of burn was >0.05 m). Notably, hydrogeological setting influenced the spatial coverage of these post-fire surface covers by influencing pre-fire WTs and stand characteristics (e.g., shading). Because feather moss cover is controlled by tree shading, lightly burned feather mosses were ubiquitous (>25%) in drier peatlands (deeper pre-fire WTs) that were densely treed and had little connection to large groundwater flow systems. Moreover, hydrogeological setting also controlled post-fire WT positions, thereby affecting moss re-establishment in post-fire surface covers that were dependent on WT position (e.g., lightly burned S. fuscum). Accordingly, higher recolonization rates were observed in a peatland located in a groundwater flow through

  5. Issues in post-literacy

    NASA Astrophysics Data System (ADS)

    Dave, Ravindra H.; Ouane, Adama; Sutton, Peter

    1989-12-01

    While school enrolments have been rising, the absolute number of illiterates in the world has grown too. Eradication of adult illiteracy and universalization of primary education are hindered by high drop-out in schools and relapse into illiteracy among adults. Post-literacy programmes seek to stop this reversal by ensuring retention, application and continuation of literacy skills. The Unesco Institute for Education (UIE) has been researching and promoting post-literacy strategies since 1980, but finds that most projects do not include provision for post-literacy from the outset, despite the evident need. Those programmes which have been mounted use a variety of strategies, which UIE has analysed in 12 categories. The exact delimitation of the post-literacy stage in the lifelong education continuum differs from project to project, and the emphasis on individual or societal advance depends on local perceptions of the goals of development. Examples are given of successful programmes, and the challenges of increasing participation and motivation, securing adequate funding, and making efficient and flexible use of institutional facilities are discussed.

  6. Job Posting: An Industry Survey

    ERIC Educational Resources Information Center

    Dahl, Dave R.; Pinto, Patrick R.

    1977-01-01

    Reports a survey to determine practices among metalworking firms in Minnesota covering such topics as whether or not the company had a formal or informal job posting system, the actual mechanics of the system, union influence on its design, feedback to unsuccessful job bidders, and current employee acceptance of the system. Recommendations are…

  7. Estonianization Efforts Post-Independence

    ERIC Educational Resources Information Center

    Rannut, Mart

    2008-01-01

    The purpose of this paper is to provide an overview of the sociolinguistic situation in Estonia. The paper opens with a historic overview, followed by an overview of the current demographic situation and of post-Soviet language and education policies and practices. It is argued that Estonia represents a success story in terms of language policy,…

  8. Reconsidering Post-Traumatic Stress

    ERIC Educational Resources Information Center

    Berman, Dene S.; Davis-Berman, Jennifer

    2005-01-01

    This article serves to challenge the prevailing wisdom that suggests that most trauma is followed by post-traumatic stress disorder (PTSD), and is best treated with critical incident stress debriefing (CISD). Instead, recent evidence suggests that many individuals exposed to stress do not experience stress responses. Even those who do, however,…

  9. STS-80 Post Flight Presentation

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The flight crew of STS-80, Cmdr. Kenneth D. Cockrell, Pilot Kent V. Rominger, Mission Specialists, Tamara E. Jernigan, Thomas D. Jones, and F. Story Musgrave give a post flight presentation of their mission. This presentation is divided into two parts first a slide presentation of still shots, and the second is a video presentation.

  10. Chaos Theory and Post Modernism

    ERIC Educational Resources Information Center

    Snell, Joel

    2009-01-01

    Chaos theory is often associated with post modernism. However, one may make the point that both terms are misunderstood. The point of this article is to define both terms and indicate their relationship. Description: Chaos theory is associated with a definition of a theory dealing with variables (butterflies) that are not directly related to a…

  11. Post-Traumatic Stress Disorder

    MedlinePlus

    Post-traumatic stress disorder (PTSD) is a real illness. You can get PTSD after living through or seeing a traumatic event, such as war, a hurricane, sexual assault, physical abuse, or a bad accident. PTSD makes you feel stressed and afraid after the danger is over. It affects your life and ...

  12. Pair take top science posts

    NASA Astrophysics Data System (ADS)

    Pockley, Peter

    2008-11-01

    Australia's science minister Kim Carr has appointed physical scientists to key posts. Penny Sackett, an astronomer, takes over as the government's chief scientist this month, while in January geologist Megan Clark will become chief executive of the Commonwealth Scientific and Industrial Research Organisation (CSIRO), the county's largest research agency. Both five-year appointments have been welcomed by researchers.

  13. Spontaneous recovery from post-traumatic hypopituitarism.

    PubMed

    Iglesias, P; Gómez-Pan, A; Diez, J J

    1996-05-01

    Recovery of the pituitary function from post-traumatic hypopituitarism is an exceptional event. We present the case of a 32 year-old man who was involved in a road traffic accident in which he suffered a severe head injury. Four days following the trauma the patient developed post-traumatic central diabetes insipidus and desmopressin was started. At discharge of the intensive care unit, the patient was referred to us for endocrine assessment. Three months after the head injury, the hormonal evaluation of the hypothalamic-pituitary axis by means of insulin stress test with the simultaneous administration of TRH and GnRH resulted in reduced responses of GH, cortisol, TSH, FSH, and LH with low baseline serum concentrations of free T4 and testosterone. Both serum basal and stimulated PRL concentrations were normal. Magnetic resonance imaging demonstrated deformity of the sella turcica with displacement of the pituitary gland by a post-traumatic retention cyst. A new evaluation of the pituitary function performed 6 months after the trauma showed spontaneous recovery of the gonadal, thyroid and adrenal function. However, GH response was reduced both to insulin-induced hypoglycemia, clonidine and GHRH tests. Presence of normal serum PRL levels, normal PRL response to TRH and reduced GH responses to pituitary and hypothalamic stimuli suggests both hypothalamic and pituitary damage. The present case shows an unusual case of partial spontaneous resolution of a post-traumatic hypopituitarism. Based on this clinical observation we recommend periodic evaluation of the pituitary function in these kind of patients.

  14. Optically Visible Post-AGB and Post-RGB Stars in the Magellanic Clouds

    NASA Astrophysics Data System (ADS)

    Kamath, D.; Wood, P. R.; Van Winckel, H.

    2015-08-01

    We have performed an extensive low-resolution (R ≍ 1300) optical spectral survey with the AAOmega multi-fiber spectrograph mounted on the 3.9-m Anglo Australian telescope, resulting in a clean and complete census of well-characterised post-AGB objects with spectroscopically determined stellar parameters - Teff, log g, [Fe/H] and E(B-V) - spanning a wide range in luminosity in the Small Magellanic Cloud (SMC) and Large Magellanic Cloud (LMC). The known distances to the Magellanic clouds enabled luminosity estimations for all the objects and led to one of the most important results of this survey: the serendipitous discovery of a group of new, low-luminosity, evolved, dusty post-RGB objects in both Clouds. In this paper, we present an overview of this survey and a few important results.

  15. Influence of cement type and thickness on polyfiber post adhesion

    PubMed Central

    Uzunoğlu, Emel; Türker, Sevinç Aktemur; Yilmaz, Zeliha

    2014-01-01

    Introduction: To evaluate the effect of two different post space diameters and related resin cement film thicknesses on the bond strength of a polyfiber post. Materials and Methods: A total of 48 premolars were randomly divided into two according to the post space diameter: 1.1 mm and 1.5 mm. Then each group was divided into three sub-groups according to luting cement used: RelyX U100, Panavia F2.0/ED primer, Clearfil SA cement. Spirapost was then luted into the canal using luting cements. Two slices were obtained from each root specimen. Push-out tests were performed. Data was analyzed with Kruskal-Wallis and Connover post-hoc and Mann-Whitney U-test (P < 0.05). Results: Push-out bond strength was found to vary significantly according to type of adhesive system and post space diameter size (P < 0.05). The self-adhesive resin cement RelyX U100 had significantly higher bond strengths compared with the other adhesive system (P < 0.05). The self-etch adhesive system (Panavia F2.0) showed significantly lower bond strengths compared with the other systems (P < 0.05). There was a significant interaction between the luting systems and post space diameter (P < 0.05). Conclusion: The increases in post space diameter significantly reduced the bond strength of Spirapost to root dentine for both groups. PMID:24944450

  16. T-Shaped Frame Critical and Post-Critical Analysis

    NASA Astrophysics Data System (ADS)

    Doicheva, Albena

    2016-03-01

    The paper shows solution of a T-shaped frame, strength- ened with two linear springs, regarding critical and post-critical analysis. The solution is exact using the Euler elastic approach and the frame of reference, originated in the point of column axis inflexion. The derived Numerical results show the effect of the springs strengthening for the crit- ical and the post-critical system behaviour. The influence of the geometry change is analyzed, as well.

  17. Pre/Post Data Analysis - Simple or Is It?

    NASA Technical Reports Server (NTRS)

    Feiveson, Al; Fiedler, James; Ploutz-Snyder, Robert

    2011-01-01

    This slide presentation reviews some of the problems of data analysis in analyzing pre and post data. Using as an example, ankle extensor strength (AES) experiments, to measure bone density loss during bed rest, the presentation discusses several questions: (1) How should we describe change? (2) Common analysis methods for comparing post to pre results. (3) What do we mean by "% change"? and (4) What are we testing when we compare % changes?

  18. An Evaluation of Fracture Strength of Zirconium Oxide Posts Fabricated Using CAD-CAM Technology Compared with Prefabricated Glass Fibre Posts.

    PubMed

    Dayalan, Malathi; Jairaj, Abhishek; Nagaraj, K R; Savadi, Ravindra C

    2010-12-01

    Post and core therapy is regarded as the treatment of choice for restoring severely damaged endodontically treated teeth. Critical control of endodontic materials in the coronal third of the canal and pulp chamber is essential in order to maintain its colour and translucency. In addition to this, the duplication of the optical characteristics of an intact tooth, including shade translucency and fluorescence is often made difficult by the use of metal infrastructures. As a result of this tooth colored posts have gained popularity especially in aesthetic areas. Besides aesthetics, the post is also responsible for transmitting the occlusal forces to the remaining tooth structure making the mechanical properties of the post critical. However, there is no clear consensus regarding an ideal system as far as strength of the post is concerned. Hence this study aims to analyses and compares the fracture strength of traditional prefabricated glass fibre posts with zirconium oxide posts constructed using CAD CAM technology. PMID:22131666

  19. MARS Science Laboratory Post-Landing Location Estimation Using Post2 Trajectory Simulation

    NASA Technical Reports Server (NTRS)

    Davis, J. L.; Shidner, Jeremy D.; Way, David W.

    2013-01-01

    The Mars Science Laboratory (MSL) Curiosity rover landed safely on Mars August 5th, 2012 at 10:32 PDT, Earth Received Time. Immediately following touchdown confirmation, best estimates of position were calculated to assist in determining official MSL locations during entry, descent and landing (EDL). Additionally, estimated balance mass impact locations were provided and used to assess how predicted locations compared to actual locations. For MSL, the Program to Optimize Simulated Trajectories II (POST2) was the primary trajectory simulation tool used to predict and assess EDL performance from cruise stage separation through rover touchdown and descent stage impact. This POST2 simulation was used during MSL operations for EDL trajectory analyses in support of maneuver decisions and imaging MSL during EDL. This paper presents the simulation methodology used and results of pre/post-landing MSL location estimates and associated imagery from Mars Reconnaissance Orbiter s (MRO) High Resolution Imaging Science Experiment (HiRISE) camera. To generate these estimates, the MSL POST2 simulation nominal and Monte Carlo data, flight telemetry from onboard navigation, relay orbiter positions from MRO and Mars Odyssey and HiRISE generated digital elevation models (DEM) were utilized. A comparison of predicted rover and balance mass location estimations against actual locations are also presented.

  20. Nebulized ketamine decreases incidence and severity of post-operative sore throat

    PubMed Central

    Ahuja, Vanita; Mitra, Sukanya; Sarna, Rashi

    2015-01-01

    Background and Aims: Post-operative sore throat (POST) occurs in 21-65% of patients. Ketamine used earlier as gargle for reducing POST has limitations. The aim of this study was to see if nebulised ketamine reduces POST. Methods: We conducted a prospective, randomised, placebo-control, and double-blind controlled trial. After written informed consent, 100 patients belonging to American Society of Anaesthesiologists physical status I-II in the age group 20-60 years, of either sex undergoing surgery under general anaesthesia (GA) were enrolled. Patients were randomised into two groups; group saline (S) received saline nebulisation 5.0 ml and group ketamine (K) received ketamine 50 mg (1.0 ml) with 4.0 ml of saline nebulisation for 15 min. GA was induced 10 min after completion of nebulisation in the patients. The POST and haemodynamic monitoring were done pre-nebulization, pre-induction, on reaching post-anaesthesia care unit, and at 2, 4, 6, 8, 12 and 24 h post-operatively. POST was graded on a four-point scale (0-3). Results: The overall incidence of POST was 33%; 23 patients (46%) in saline and 10 patients (20%) in ketamine group experienced POST (Fisher's exact P = 0.01). The use of ketamine nebulization attenuated POST at 2 h and 4 h post-operatively (P < 0.05). The primary outcome was incidence of POST at 4 h; 13 patients in group S versus 4 patients in group K (P = 0.03) experienced POST at 4 h. The moderate sore throat occurred in 6 patients in group S and none in group K at 2 h, post-operatively (P = 0.02). Conclusion: Ketamine nebulization significantly attenuated the incidence and severity of POST, especially in the early post-operative period, with no adverse effects. PMID:25684812

  1. The ISAC post-accelerator

    NASA Astrophysics Data System (ADS)

    Laxdal, R. E.; Marchetto, M.

    2014-01-01

    The acceleration chain of the ISAC facility boosts the energy of both radioactive and stable light and heavy ions for beam delivery to both a medium energy area in ISAC-I and a high energy area in ISAC-II. The post-accelerator comprises a 35.4 MHz RFQ to accelerate beams of A/q ≤ 30 from 2 keV/u to 150 keV/u and a post stripper, 106.1 MHz variable energy drift tube linac (DTL) to accelerate ions of A/q ≤ 6 to a final energy between 0.15 MeV/u to 1.5 MeV/u. A 40 MV superconducting linac further accelerates beam from 1.5 MeV/u to energies above the Coulomb barrier. All linacs operate cw to preserve beam intensity.

  2. Post-Lyme disease syndrome

    PubMed Central

    Dąbek, Józefa; Cieślik, Paweł

    2015-01-01

    About 10% of patients with Lyme disease continue to experience musculoskeletal pain and cognitive dysfunction after recommended antibiotic treatment. This condition is called post-Lyme disease syndrome (PLDS) or post-treatment Lyme disease syndrome. These two terms are used interchangeably. The pathogenesis of PLDS has been controversial. The hypothesis that patients with PLDS may harbor hidden reservoirs of Borrelia burgdorferi after their initial antibiotic treatment is difficult to accept. The prospective, double-blind studies contradict this point of view. Also, recently published research applying xenodiagnosis to PLDS supports the opinion that PLDS most likely has an autoimmune background. Lengthy courses of antibiotics are not justified in patients with PLDS because of the lack of benefit, and they are fraught with hazards. Most patients with PLDS recover from persistent symptoms with time. However, it can take months before they feel completely well. PMID:27407225

  3. Post-burnout thrust measurements

    NASA Astrophysics Data System (ADS)

    McKenna, E. F.; Smith, H. T.

    1980-06-01

    Research was conducted into the problems of avoiding collision between separated payloads and spent rocket motors due to post burnout thrust, and the problem of contamination of scientific instrumentation due to outgassing of the smoldering insulation. The post burnout thrust was measured using a payload instrument module separated from an instrumented Black Brant VC Rocket in the exoatmosphere. In addition to measuring acceleration and velocities the spent motor was observed by a TV camera on board the command attitude controlled payload module. Analysis shows that the payload separated cleanly from the vehicle at a relative separation velocity of 0.69 m/sec, however the residual thrust of the spent motor overcame this differential, catching up to the payload 37 sec after separation and continuing on a parallel velocity vector at about 1.03 m/sec.

  4. Leg ischemia post-varicocelectomy

    PubMed Central

    Al-Wahbi, Abdullah M; Elmoukaied, Shaza

    2016-01-01

    Varicocelectomy is the most commonly performed operation for the treatment of male infertility. Many surgical approaches are used as each of them has advantages over the other and is preferred by surgeons. Vascular injury has never been reported as a complication of varicocelectomy apart from testicular artery injury. We present a 36-year-old male who developed leg ischemia post-varicocelectomy due to common femoral artery injury. He was successfully treated by using a vein graft. PMID:27022305

  5. The SPOOKI post production system

    NASA Astrophysics Data System (ADS)

    Beauchemin, M.; Klasa, M.; Fortier, S.; Fortin, F.; Hardy, G.; Pelletier, L.; Edouard, S.; Archambault, B.; Yazidi, H.

    2010-09-01

    The Canadian Meteorological Centre (CMC) delivers a large number of numerical weather prediction products to the various weather offices and clients throughout Canada and abroad. The current post production system was built according to the needs and ideology of the 1980's and it is becoming obsolete with time. Its cumbersome architecture is difficult to maintain and requires a lot of human and computing resources. The "Weather Elements" section of CMC is aware of the problems associated with its maintenance in the long term and has therefore decided to review in depth the whole approach to the operational post production. The analysis of present and future needs have led to the development of an innovative concept in the operational production field inspired by the "Plug and Play" process. SPOOKI (Système de Production Orienté-Objet contennant une Kyrielle d'Informations - Object oriented production system containing a myriad of information) was created in its present form in 2007. It is based on a modular approach where each plug-in component is specialized, reusable and autonomous. These object oriented programming characteristics greatly simplify the maintenance of the system. Particular attention was also given to create a user-friendly system for novice users. An experimental version of SPOOKI is currently running in development mode and an operational one is planned to be implemented in the coming year. The poster presentation will describe SPOOKI, the future CMC operational post production system. Several examples of usage will be shown.

  6. Are Post-Main Sequence Planets Doomed?

    NASA Astrophysics Data System (ADS)

    Villaver, E.

    2014-04-01

    Post-main sequence evolution directly affects the survival of planetary and sub-planetary mass bodies. Planets orbiting evolved stars undergo orbital evolution under the influence of tides and mass-loss, can be ejected, evaporated, and suffer multiple-body instabilities. The conditions on the planet surface are expected to be modified as well as the result of the evolution of the star. I will discuss the new limits that the theoretical studies allow us to set on the survival and habitability of planets as the star runs out of its hydrogen fuel.

  7. Post-pancreatitis Fat Necrosis Mimicking Carcinomatosis.

    PubMed

    Smith, Joshua P; Arnoletti, J Pablo; Varadarajulu, Shyam; Morgan, Desiree E

    2008-01-01

    Acute pancreatitis can result in retroperitoneal fat necrosis, typically occurring in the peripancreatic region, with extension into the transverse mesocolon, omentum and mesenteric root. When evaluated with contrast enhanced computed tomography (CECT), acute peripancreatic post necrotic collections typically become lower in attenuation over time, and often appear as homogeneous fluid collections. Saponification as a complication of fat necrosis in patients with acute pancreatitis is a well recognized clinical entity. While retroperitonal fat necrosis is commonly seen on CECT, saponification is not a prominent imaging feature. We present a case of acute pancreatitis complicated by extensive saponification of fat throughout the retroperitoneum and peritoneal lining, mimicking carcinomatosis.

  8. The Post-Communist Fertility Puzzle.

    PubMed

    Billingsley, Sunnee

    2010-04-01

    Fertility has unanimously declined across the entire post-communist region. This study explores the variation in fertility trends over time among these countries and assesses to what degree three explanations are applicable: second demographic transition (SDT), postponement transition (PPT) or reaction to the economic crisis. Moreover, on the basis of SDT and PPT theoretical tenets, as well as descriptive evidence, the economic context is hypothesized to be linked to two processes of fertility decline conversely. The results show that no one theoretical explanation is sufficient to explain the complex fertility declines across the entire post-communist region from 1990 to 2003. In some countries, a great part of the decline in fertility occurred before significant postponement of childbearing began, which indicates that the dramatic decline was due to stopping behavior or postponement of higher order births. Postponement of first births, either through PPT or SDT processes, greatly contributed to fertility decline in a small number of countries. Pooled cross-sectional time-series analyses of age-specific birthrates confirm that these two distinct processes are present and show that the economic crisis explanation has explanatory power for declining birth rates. In contrast, logistic regressions show that the likelihood of postponing childbirth increases with improved economic conditions. These results confirm the importance of taking the economic context into account when discussing explanations for fertility decline. More specifically, the results indicate that the severity and duration of economic crisis, or absence thereof, influenced the extent and manner in which fertility declined.

  9. Evaluating the Benefits of Aphasia Intervention Delivered in Virtual Reality: Results of a Quasi-Randomised Study

    PubMed Central

    Marshall, Jane; Booth, Tracey; Devane, Niamh; Galliers, Julia; Greenwood, Helen; Hilari, Katerina; Talbot, Richard; Wilson, Stephanie; Woolf, Celia

    2016-01-01

    Introduction This study evaluated an intervention for people with aphasia delivered in a novel virtual reality platform called EVA Park. EVA Park contains a number of functional and fantastic locations and allows for interactive communication between multiple users. Twenty people with aphasia had 5 weeks’ intervention, during which they received daily language stimulation sessions in EVA Park from a support worker. The study employed a quasi randomised design, which compared a group that received immediate intervention with a waitlist control group. Outcome measures explored the effects of intervention on communication and language skills, communicative confidence and feelings of social isolation. Compliance with the intervention was also explored through attrition and usage data. Results There was excellent compliance with the intervention, with no participants lost to follow up and most (18/20) receiving at least 88% of the intended treatment dose. Intervention brought about significant gains on a measure of functional communication. Gains were achieved by both groups of participants, once intervention was received, and were well maintained. Changes on the measures of communicative confidence and feelings of social isolation were not achieved. Results are discussed with reference to previous aphasia therapy findings. PMID:27518188

  10. Spectroscopic survey of post-AGB star candidates

    NASA Astrophysics Data System (ADS)

    Pereira, C. B.; Miranda, L. F.

    2007-01-01

    Aims:Our goal is to establish the true nature of post-AGB star candidates and to identify new post-AGB stars. Methods: We used low resolution optical spectroscopy and we compared the spectra of the candidate post-AGB stars with those of stars in the library specta available in the literature and with spectra of "standard" post-AGB stars, and direct imaging in narrow-band filters. Results: Spectra were obtained for 16 objects: 14 objects have not been observed previously and 2 objects are already known post-AGB stars used as "standards" for identification. From the spectra we identify: six new post-AGB stars with spectral types between G5 and F5, two H ii regions the morphology of which is revealed in the direct images for the first time, a G giant with infrared emission, a young stellar object, a probable post-AGB star with emission lines and three objects for which the classification is still unclear. As a whole, our results provide new, reliable identifications for 10 objects among listed post-AGB star candidates. Based on observations collected at the Centro Astronómico Hispano Alemán (CAHA) at Calar Alto, operated jointly by the Max-Planck Institut für Astronomie and the Instituto de Astrofísica de Andalucía (CSIC), and at the Observatorio de Sierra Nevada, which is operated by the Consejo Superior de Investigaciones Científicas through the Instituto de Astrofísica de Andalucía (Granada, Spain). Appendices A-D are only available in electronic form at http://www.aanda.org

  11. Post-stroke language disorders.

    PubMed

    Sinanović, Osman; Mrkonjić, Zamir; Zukić, Sanela; Vidović, Mirjana; Imamović, Kata

    2011-03-01

    Post-stroke language disorders are frequent and include aphasia, alexia, agraphia and acalculia. There are different definitions of aphasias, but the most widely accepted neurologic and/or neuropsychological definition is that aphasia is a loss or impairment of verbal communication, which occurs as a consequence of brain dysfunction. It manifests as impairment of almost all verbal abilities, e.g., abnormal verbal expression, difficulties in understanding spoken or written language, repetition, naming, reading and writing. During the history, many classifications of aphasia syndromes were established. For practical use, classification of aphasias according to fluency, comprehension and abilities of naming it seems to be most suitable (nonfluent aphasias: Broca's, transcortical motor, global and mixed transcortical aphasia; fluent aphasias: anomic, conduction, Wernicke's, transcortical sensory, subcortical aphasia). Aphasia is a common consequence of left hemispheric lesion and most common neuropsychological consequence of stroke, with a prevalence of one-third of all stroke patients in acute phase, although there are reports on even higher figures. Many speech impairments have a tendency of spontaneous recovery. Spontaneous recovery is most remarkable in the first three months after stroke onset. Recovery of aphasias caused by ischemic stroke occurs earlier and it is most intensive in the first two weeks. In aphasias caused by hemorrhagic stroke, spontaneous recovery is slower and occurs from the fourth to the eighth week after stroke. The course and outcome of aphasia depend greatly on the type of aphasia. Regardless of the fact that a significant number of aphasias spontaneously improve, it is necessary to start treatment as soon as possible. The writing and reading disorders in stroke patients (alexias and agraphias) are more frequent than verified on routine examination, not only in less developed but also in large neurologic departments. Alexia is an acquired

  12. Post-stroke language disorders.

    PubMed

    Sinanović, Osman; Mrkonjić, Zamir; Zukić, Sanela; Vidović, Mirjana; Imamović, Kata

    2011-03-01

    Post-stroke language disorders are frequent and include aphasia, alexia, agraphia and acalculia. There are different definitions of aphasias, but the most widely accepted neurologic and/or neuropsychological definition is that aphasia is a loss or impairment of verbal communication, which occurs as a consequence of brain dysfunction. It manifests as impairment of almost all verbal abilities, e.g., abnormal verbal expression, difficulties in understanding spoken or written language, repetition, naming, reading and writing. During the history, many classifications of aphasia syndromes were established. For practical use, classification of aphasias according to fluency, comprehension and abilities of naming it seems to be most suitable (nonfluent aphasias: Broca's, transcortical motor, global and mixed transcortical aphasia; fluent aphasias: anomic, conduction, Wernicke's, transcortical sensory, subcortical aphasia). Aphasia is a common consequence of left hemispheric lesion and most common neuropsychological consequence of stroke, with a prevalence of one-third of all stroke patients in acute phase, although there are reports on even higher figures. Many speech impairments have a tendency of spontaneous recovery. Spontaneous recovery is most remarkable in the first three months after stroke onset. Recovery of aphasias caused by ischemic stroke occurs earlier and it is most intensive in the first two weeks. In aphasias caused by hemorrhagic stroke, spontaneous recovery is slower and occurs from the fourth to the eighth week after stroke. The course and outcome of aphasia depend greatly on the type of aphasia. Regardless of the fact that a significant number of aphasias spontaneously improve, it is necessary to start treatment as soon as possible. The writing and reading disorders in stroke patients (alexias and agraphias) are more frequent than verified on routine examination, not only in less developed but also in large neurologic departments. Alexia is an acquired

  13. Post-traumatic extrapyramidal syndrome: case report.

    PubMed

    Della Sala, S; Mazzini, L

    1990-02-01

    We report the case of a young man with possible post-traumatic extrapyramidal syndrome. Some features of this case have a bearing on the controversy surrounding the existence of post-traumatic Parkinson disease.

  14. 76 FR 53984 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ... informs the public that an appeal of the closing of the Prairie Hill, Texas post office has been filed. It... for review of the Postal Service's determination to close the Prairie Hill post office in Prairie...

  15. 42 CFR 124.604 - Posted notice.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... facility shall post notices, which the Secretary supplies in English and Spanish, in appropriate areas of... other than English or Spanish, the facility shall translate the notice into that language and post...

  16. 75 FR 70956 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-19

    ... informs the public that an appeal of the closing of the Lancaster, Tennessee post office has been filed... for review of the closing of the Lancaster Post Office located in Lancaster, Tennessee. The...

  17. 42 CFR 124.604 - Posted notice.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... other than English or Spanish, the facility shall translate the notice into that language and post the translated notice on signs substantially similar in size and legibility to, and posted with, those...

  18. 42 CFR 124.604 - Posted notice.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... other than English or Spanish, the facility shall translate the notice into that language and post the translated notice on signs substantially similar in size and legibility to, and posted with, those...

  19. 42 CFR 124.604 - Posted notice.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... other than English or Spanish, the facility shall translate the notice into that language and post the translated notice on signs substantially similar in size and legibility to, and posted with, those...

  20. 42 CFR 124.604 - Posted notice.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... other than English or Spanish, the facility shall translate the notice into that language and post the translated notice on signs substantially similar in size and legibility to, and posted with, those...

  1. 76 FR 46857 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-03

    ... informs the public that an appeal of the closing of the Still Pond, Maryland post office has been filed... review of the Postal Service's determination to close the post office in Still Pond, Maryland....

  2. 77 FR 3806 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ... From the Federal Register Online via the Government Publishing Office POSTAL REGULATORY COMMISSION Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document... Station post office in Yerington, Nevada. The first petition for review received December 28, 2011,...

  3. 76 FR 44385 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-25

    ... informs the public that an appeal of the closing of the Peach Orchard, Arkansas post office has been filed... review of the closing of the Peach Orchard, Arkansas post office. The petition, which was filed...

  4. Post-Traumatic Stress Disorder (PDQ)

    MedlinePlus

    ... with post-traumatic stress need early treatment with methods that are used to treat other trauma victims. ... symptoms of post-traumatic stress. The crisis intervention method aims to relieve distress and help the patient ...

  5. 76 FR 62460 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... informs the public that an appeal of the closing of the La Grande, Washington post office has been filed... petition for review of the Postal Service's determination to close the La Grande post office in La...

  6. 76 FR 58057 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ... informs the public that an appeal of the closing of the Burnt Prairie, Illinois post office has been filed... for review of the Postal Service's determination to close the Burnt Prairie post office in...

  7. 76 FR 77273 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-12

    ... informs the public that an appeal of the closing of the Burns, Colorado post office has been filed. It... for review of the Postal Service's determination to close the Burns post office in Burns,...

  8. 76 FR 57083 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... informs the public that an appeal of the closing of the Etna, New York post office has been filed. It... for review of the Postal Service's determination to close the Etna post office in Etna, New York....

  9. Leaching of copper, chromium and arsenic from treated vineyard posts in Marlborough, New Zealand.

    PubMed

    Robinson, Brett; Greven, Marc; Green, Steve; Sivakumaran, Siva; Davidson, Peter; Clothier, Brent

    2006-07-01

    There have been conflicting reports as to the extent that copper-chromium-arsenic (CCA) treatments leach from timber. In New Zealand, vineyards utilise CCA-treated posts at a rate of 579 posts per hectare. This represents a potential CCA burden on the soil of 12, 21, and 17 kg/ha, respectively, for the three elements. Given a replacement rate of 4% per year, the use of CCA-treated posts may result in an accumulation of these elements in the soil, possibly leading to groundwater contamination. We undertook a general survey to determine the extent of CCA leaching from treated vineyard posts. Treated Pinus radiata posts were sampled at six sites around the Marlborough region of New Zealand to represent a range of post ages and soil types. For each post, above- and belowground wood samples were taken. As well, the soil adjacent to the post was sampled at a 50 mm horizontal and 100 mm vertical distances from the post. The belowground wood samples of the posts had significantly lower CCA concentrations than the aboveground portions, which were not significantly different from new posts. This indicates leaching. Soils surrounding the posts had significantly higher CCA concentrations than control soils. Higher CCA concentrations were measured under the posts than laterally. Some 25% of the samples exceeded 100 mg/kg As, the Australian National Environment Protection Council (ANEPC) guideline level for As in agricultural soil, and 10% exceeded 100 mg/kg Cr, the ANEPC limit for chromium. At one site, we found a significant positive correlation between post age and CCA-leaching. The CCA issue could be eliminated by using alternative posts, such as steel, concrete, or untreated woods such as Eucalyptus or beech. Alternatively, CCA-treated posts could, for example, be lacquered or otherwise protected, to reduce the rate of CCA leaching.

  10. Finite element analysis and fracture resistance testing of a new intraradicular post

    PubMed Central

    YAMAMOTO, Eron Toshio Colauto; PAGANI, Clovis; da SILVA, Eduardo Galera; NORITOMI, Pedro Yoshito; UEHARA, André Yugou; KEMMOKU, Daniel Takanori

    2012-01-01

    Objectives The objective of the present study was to evaluate a prefabricated intraradicular threaded pure titanium post, designed and developed at the São José dos Campos School of Dentistry - UNESP, Brazil. This new post was designed to minimize stresses observed with prefabricated post systems and to improve cost-benefits. Material and methods Fracture resistance testing of the post/core/root complex, fracture analysis by microscopy and stress analysis by the finite element method were used for post evaluation. The following four prefabricated metal post systems were analyzed: group 1, experimental post; group 2, modification of the experimental post; group 3, Flexi Post, and group 4, Para Post. For the analysis of fracture resistance, 40 bovine teeth were randomly assigned to the four groups (n=10) and used for the fabrication of test specimens simulating the situation in the mouth. The test specimens were subjected to compressive strength testing until fracture in an EMIC universal testing machine. After fracture of the test specimens, their roots were sectioned and analyzed by microscopy. For the finite element method, specimens of the fracture resistance test were simulated by computer modeling to determine the stress distribution pattern in the post systems studied. Results The fracture test presented the following averages and standard deviation: G1 (45.63±8.77), G2 (49.98±7.08), G3 (43.84±5.52), G4 (47.61±7.23). Stress was homogenously distributed along the body of the intraradicular post in group 1, whereas high stress concentrations in certain regions were observed in the other groups. These stress concentrations in the body of the post induced the same stress concentration in root dentin. Conclusions The experimental post (original and modified versions) presented similar fracture resistance and better results in the stress analysis when compared with the commercial post systems tested (08/2008-PA/CEP). PMID:23032204

  11. 10 CFR 160.6 - Posting.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Posting. 160.6 Section 160.6 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) TRESPASSING ON COMMISSION PROPERTY § 160.6 Posting. Notices stating the pertinent prohibitions of §§ 160.3 and 160.4 and penalties of § 160.5 will be conspicuously posted at all entrances...

  12. 76 FR 59451 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-26

    ... informs the public that an appeal of the closing of the Coyote, New Mexico post office has been filed. It... Postal Service's determination to close the Coyote post office in Coyote, New Mexico. The petition was filed by Manuelita Trujillo on behalf of the Concerned Citizens of the Coyote Post Office...

  13. 10 CFR 20.1902 - Posting requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... HIGH RADIATION AREA.” (d) Posting of airborne radioactivity areas. The licensee shall post each airborne radioactivity area with a conspicuous sign or signs bearing the radiation symbol and the words “CAUTION, AIRBORNE RADIOACTIVITY AREA” or “DANGER, AIRBORNE RADIOACTIVITY AREA.” (e) Posting of areas...

  14. 10 CFR 20.1902 - Posting requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... HIGH RADIATION AREA.” (d) Posting of airborne radioactivity areas. The licensee shall post each airborne radioactivity area with a conspicuous sign or signs bearing the radiation symbol and the words “CAUTION, AIRBORNE RADIOACTIVITY AREA” or “DANGER, AIRBORNE RADIOACTIVITY AREA.” (e) Posting of areas...

  15. 10 CFR 20.1902 - Posting requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... HIGH RADIATION AREA.” (d) Posting of airborne radioactivity areas. The licensee shall post each airborne radioactivity area with a conspicuous sign or signs bearing the radiation symbol and the words “CAUTION, AIRBORNE RADIOACTIVITY AREA” or “DANGER, AIRBORNE RADIOACTIVITY AREA.” (e) Posting of areas...

  16. 10 CFR 20.1902 - Posting requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... HIGH RADIATION AREA.” (d) Posting of airborne radioactivity areas. The licensee shall post each airborne radioactivity area with a conspicuous sign or signs bearing the radiation symbol and the words “CAUTION, AIRBORNE RADIOACTIVITY AREA” or “DANGER, AIRBORNE RADIOACTIVITY AREA.” (e) Posting of areas...

  17. 10 CFR 20.1902 - Posting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... HIGH RADIATION AREA.” (d) Posting of airborne radioactivity areas. The licensee shall post each airborne radioactivity area with a conspicuous sign or signs bearing the radiation symbol and the words “CAUTION, AIRBORNE RADIOACTIVITY AREA” or “DANGER, AIRBORNE RADIOACTIVITY AREA.” (e) Posting of areas...

  18. Post-Colonial Theory and Action Research

    ERIC Educational Resources Information Center

    Parsons, Jim B.; Harding, Kelly J.

    2011-01-01

    This essay explores connections between post-colonial theory and action research. Post-colonial theory is committed to addressing the plague of colonialism. Action research, at its core, promises to problematize uncontested "colonial" hegemonies of any form. Both post-colonial theory and action research engage dialogic, critically reflective and…

  19. 36 CFR 261.51 - Posting.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Posting. 261.51 Section 261.51 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS Prohibitions in Areas Designated by Order § 261.51 Posting. Posting is accomplished by: (a) Placing a copy...

  20. 76 FR 69773 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-09

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Beech Grove, Kentucky post office has been filed... received a petition for review of the Postal Service's determination to close the Beech Grove post...

  1. 76 FR 67498 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-01

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Venice, California post office has been filed. It... close the Venice post office in Venice, California. The petition for review was filed online on...

  2. 48 CFR 752.7029 - Post privileges.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Post privileges. 752.7029... FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of USAID Contract Clauses 752.7029 Post privileges. For use in all USAID non-commercial contracts involving performance overseas. Post...

  3. 77 FR 1958 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-12

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Jonesville, Texas post office has been filed. It... post office in Jonesville, Texas. The first petition for review, which included an application...

  4. 76 FR 60947 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Jordanville, New York post office has been filed... petition for review of the Postal Service's determination to close the Jordanville post office...

  5. 48 CFR 752.7029 - Post privileges.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Post privileges. 752.7029... FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of USAID Contract Clauses 752.7029 Post privileges. For use in all USAID non-commercial contracts involving performance overseas. Post...

  6. 48 CFR 752.7029 - Post privileges.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Post privileges. 752.7029... FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of USAID Contract Clauses 752.7029 Post privileges. For use in all USAID non-commercial contracts involving performance overseas. Post...

  7. 76 FR 62461 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Oak Hill, Alabama post office has been filed. It... Postal Service's determination to close the Oak Hill post office in Oak Hill, Alabama. The petition...

  8. 76 FR 45301 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-28

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Unionville, Iowa post office has been filed. It... closing of the post office in Unionville, Iowa. The petition, which was filed by Dorothy Jean...

  9. 76 FR 75916 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-05

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Prince, West Virginia post office has been filed... received a petition for review of the Postal Service's determination to close the Prince post office...

  10. 37 CFR 2.81 - Post publication.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Post publication. 2.81 Section 2.81 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Publication and Post Publication § 2.81 Post publication....

  11. 37 CFR 2.81 - Post publication.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false Post publication. 2.81 Section 2.81 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Publication and Post Publication § 2.81 Post publication....

  12. 77 FR 1755 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Halsey, Nebraska post office has been filed. It... Halsey post office in Halsey, Nebraska. The first petition for review received December 16, 2011,...

  13. 76 FR 67003 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-28

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Adona, Arkansas post office has been filed. It... received a petition for review of the Postal Service's determination to close the Adona post office...

  14. 76 FR 45625 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-29

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Rodney, Iowa post office has been filed. It... Service's determination to close the post office in Rodney, Iowa. The petition, which was filed by...

  15. 76 FR 77025 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-09

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Avalon, Texas post office has been filed. It... received a petition for review of the Postal Service's determination to close the Avalon post office...

  16. 76 FR 51067 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Stoy, Illinois post office has been filed. It... Postal Service's determination to close the post office in Stoy, Illinois. The petition was filed by...

  17. 76 FR 28103 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Gywnedd, Pennsylvania post office has been filed... of the Gwynedd, Pennsylvania post office. The petition, which was filed by Christina...

  18. 76 FR 82003 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-29

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Fostoria, Iowa post office has been filed. It... post office in Fostoria, IA. The first petition for review received November 30, 2011, was filed...

  19. 76 FR 75918 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-05

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Lanagan, Missouri post office has been filed. It... received a petition for review of the Postal Service's determination to close the Lanagan post office...

  20. 76 FR 75569 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-02

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Prescott, Iowa post office has been filed. It... for review of the Postal Service's determination to close the Prescott post office in Prescott,...

  1. 48 CFR 752.7029 - Post privileges.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Post privileges. 752.7029... FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of USAID Contract Clauses 752.7029 Post privileges. For use in all USAID non-commercial contracts involving performance overseas. Post...

  2. 37 CFR 2.81 - Post publication.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Post publication. 2.81 Section 2.81 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Publication and Post Publication § 2.81 Post publication....

  3. 76 FR 61758 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-05

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Argyle, Florida post office has been filed. It... Postal Service's determination to close the Argyle post office in Argyle, Florida. The petition was...

  4. 76 FR 62462 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the West Leyden, New York post office has been filed... Leyden post office in West Leyden, New York. The petition for review was filed by the Town of Lewis...

  5. 76 FR 51066 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Rex, North Carolina post office has been filed. It... Postal Service's determination to close the post office in Rex, North Carolina. The petition was filed...

  6. 77 FR 1963 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-12

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Cardwell, Montana post office has been filed. It... post office in Cardwell, Montana. The first petition for review received December 22, 2011, was...

  7. 49 CFR 238.213 - Corner posts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Corner posts. 238.213 Section 238.213... Equipment § 238.213 Corner posts. (a)(1) Except as further specified in paragraphs (b) and (c) of this... occupied volume, two full-height corner posts, each capable of resisting together with its supporting...

  8. 77 FR 4380 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-27

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Ponce de Leon, Missouri post office has been filed... de Leon Post Office in Ponce de Leon, Missouri. The petition for review received January 6, 2012,...

  9. 76 FR 75568 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-02

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the New Cambria, Kansas post office has been filed. It... received a petition for review of the Postal Service's determination to close the New Cambria post...

  10. 76 FR 53159 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-25

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Ida, Arkansas post office has been filed. It... Postal Service's determination to close the post office in Ida, Arkansas. The petition was filed...

  11. 76 FR 80416 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-23

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Mt. Sterling, Wisconsin post office has been filed... determination to close the Mt. Sterling post office in Mt. Sterling, Wisconsin. The petition for review...

  12. 77 FR 4379 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-27

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Highfalls, North Carolina post office has been... Highfalls post office in Highfalls, North Carolina. The petition for review received January 11, 2012,...

  13. 76 FR 64979 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-19

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Humbird, Wisconsin post office has been filed. It... received a petition for review of the Postal Service's determination to close the Humbird post office...

  14. 77 FR 1751 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Strandquist, Minnesota post office has been filed... Postal Service's determination to close the Strandquist post office in Strandquist, Minnesota....

  15. 76 FR 71083 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-16

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Andover, Illinois post office has been filed. It... received a petition for review of the Postal Service's determination to close the Andover post office...

  16. 76 FR 60946 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the North Canton, Connecticut post office has been... petition for review of the Postal Service's determination to close the North Canton post office in...

  17. 76 FR 19149 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Wesleyville Post Office in Wesleyville... for review of the Postal Service's determination to close the Wesleyville, Pennsylvania post...

  18. 76 FR 45624 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-29

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Hamilton, Iowa post office has been filed. It... Service's determination to close the post office in Hamilton, Iowa. The petition, which was filed by...

  19. 76 FR 47274 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-04

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Innis, Louisiana post office has been filed. It... Service's determination to close the post office in Innis, Louisiana. The petition was filed by...

  20. 49 CFR 238.211 - Collision posts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Collision posts. 238.211 Section 238.211... Equipment § 238.211 Collision posts. (a) Except as further specified in this paragraph, paragraphs (b... time on or after September 8, 2000, shall have either: (i) Two full-height collision posts, located...

  1. 37 CFR 2.81 - Post publication.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Post publication. 2.81 Section 2.81 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Publication and Post Publication § 2.81 Post publication....

  2. 76 FR 80413 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-23

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Alplaus, New York post office has been filed. It... close the Alplaus post office in Alplaus, New York. The petition for review was filed by Andy...

  3. 76 FR 60949 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Climax, New York post office has been filed. It... Postal Service's determination to close the Climax post office in Climax, New York. The petition...

  4. 77 FR 3809 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Pierceville, Indiana post office has been filed... Pierceville post office in Pierceville, Indiana. The first petition for review received December 28, 2011,...

  5. 76 FR 46331 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-02

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Bigelow, Arkansas post office has been filed. It... Service's determination to close the post office in Bigelow, Arkansas. The petition was filed by...

  6. 76 FR 56822 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Gepp, Arkansas post office has been filed. It... Postal Service's determination to close the Gepp post office in Gepp, Arkansas. The petition was...

  7. 77 FR 1960 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-12

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Shaftsburg, Michigan post office has been filed... Shaftsburg post office in Shaftsburg, Michigan. The first petition for review received December 27, 2011,...

  8. 76 FR 60945 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Belk, Alabama post office has been filed. It... Postal Service's determination to close the Belk post office in Belk, Alabama. The petition was filed...

  9. 76 FR 62468 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Ingleside, Maryland post office has been filed. It... Postal Service's determination to close the Ingleside post office in Ingleside, Maryland. The...

  10. 49 CFR 238.211 - Collision posts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Collision posts. 238.211 Section 238.211... Equipment § 238.211 Collision posts. (a) Except as further specified in this paragraph, paragraphs (b... time on or after September 8, 2000, shall have either: (i) Two full-height collision posts, located...

  11. 76 FR 44054 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-22

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Ukiah, California Main Post Office has been filed... review of the closing of the Ukiah Main Post Office, Ukiah, California. The petition, which was filed...

  12. 76 FR 77026 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-09

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Niagara, North Dakota post office has been filed... petitions for review of the Postal Service's determination to close the Niagara post office in...

  13. 49 CFR 238.213 - Corner posts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Corner posts. 238.213 Section 238.213... Equipment § 238.213 Corner posts. (a)(1) Except as further specified in paragraphs (b) and (c) of this... occupied volume, two full-height corner posts, each capable of resisting together with its supporting...

  14. 76 FR 55952 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-09

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Velpen, Indiana post office has been filed. It... for review of the Postal Service's determination to close the Velpen post office in Velpen,...

  15. 76 FR 47614 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-05

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Pilot Grove, Iowa post office has been filed. It... of the Postal Service's determination to close the post office in Pilot Grove, Iowa. The...

  16. 49 CFR 238.213 - Corner posts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Corner posts. 238.213 Section 238.213... Equipment § 238.213 Corner posts. (a)(1) Except as further specified in paragraphs (b) and (c) of this... occupied volume, two full-height corner posts, each capable of resisting together with its supporting...

  17. 76 FR 70175 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-10

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the New Boston, Illinois post office has been filed... received two petitions for review of the Postal Service's determination to close the New Boston post...

  18. 75 FR 4429 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-27

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Sundance, CO, post office has been filed. It... closing of the Sundance post office located in Steamboat Springs, Colorado 80487. The appeal was...

  19. 76 FR 77028 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-09

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Geuda Springs, Kansas post office has been filed... for review of the Postal Service's determination to close the Geuda Springs post office in...

  20. 76 FR 80414 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-23

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Freeport, Kansas post office has been filed. It... close the Freeport post office in Freeport, Kansas. The petition for review was filed by Carol...

  1. 48 CFR 752.7029 - Post privileges.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Post privileges. 752.7029... FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of USAID Contract Clauses 752.7029 Post privileges. For use in all USAID non-commercial contracts involving performance overseas. Post...

  2. 76 FR 67001 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-28

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Witter, Arkansas post office has been filed. It... received a petition for review of the Postal Service's determination to close the Witter post office...

  3. 76 FR 46332 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-02

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Minneapolis, North Carolina post office has been... review of the Postal Service's determination to close the post office in Minneapolis, North Carolina....

  4. 76 FR 58847 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-22

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Langston, Alabama post office has been filed. It... Postal Service's determination to close the Langston post office in Langston, Alabama. The petition...

  5. 76 FR 69771 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-09

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Kettlersville, Ohio post office has been filed. It... received a petition for review of the Postal Service's determination to close the Kettlersville post...

  6. 76 FR 70173 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-10

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the West Edmeston, New York post office has been filed... received a petition for review of the Postal Service's determination to close the West Edmeston post...

  7. 76 FR 62466 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Mallory, New York post office has been filed. It... Postal Service's determination to close the Mallory post office in Mallory, New York. The petition...

  8. 76 FR 55951 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-09

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Bentonville, Ohio post office has been filed. It... for review of the Postal Service's determination to close the Bentonville post office in...

  9. 39 CFR 241.1 - Post offices.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Post offices. 241.1 Section 241.1 Postal Service... DISCONTINUANCE § 241.1 Post offices. (a) Establishment. See § 113.1 of this chapter. (b) Classification. As of July 1 each year, post offices are classified by the Postmaster General based on the allowable...

  10. 76 FR 46334 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-02

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Chillicothe, Iowa post office has been filed. It... Service's determination to close the post office in Chillicothe, Iowa. The petition was filed by Jason...

  11. 76 FR 52720 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-23

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Francitas, Texas post office has been filed. It... Postal Service's determination to close the post office in Francitas, Texas. The petition was filed...

  12. 76 FR 69770 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-09

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Boles, Arkansas post office has been filed. It... received a petition for review of the Postal Service's determination to close the Boles post office...

  13. 77 FR 1091 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-09

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Alvord, Iowa post office has been filed. It... determination to close the Alvord post office in Alvord, Iowa. The first petition for review received ]...

  14. 76 FR 62465 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Freedom, Wyoming post office has been filed. It... the Postal Service's determination to close the Freedom post office in Freedom, Wyoming. The...

  15. 76 FR 62464 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Auburn, West Virginia post office has been filed... petition for review of the Postal Service's determination to close the Auburn post office in Auburn,...

  16. 76 FR 63678 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Lorraine, New York post office has been filed. It... received a petition for review of the Postal Service's determination to close the Lorraine post office...

  17. 76 FR 62463 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Carolina, West Virginia post office has been filed... petition for review of the Postal Service's determination to close the Carolina post office in...

  18. 76 FR 45882 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-01

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Goodwin, Arkansas post office has been filed. It... Service's determination to close the post office in Goodwin, Arkansas. The petition was filed by...

  19. 76 FR 28104 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Tateville, Kentucky post office has been filed. It... closing of the Tateville, Kentucky post office. Petitions were filed by Rebecca Kroell, Glenn Walker,...

  20. 37 CFR 2.81 - Post publication.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Post publication. 2.81 Section 2.81 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Publication and Post Publication § 2.81 Post publication....

  1. 76 FR 71084 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-16

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Orchard, Iowa post office has been filed. It... received two petitions for review of the Postal Service's determination to close the Orchard post office...

  2. 76 FR 70174 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-10

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Amoret, Missouri post office has been filed. It... received a petition for review of the Postal Service's determination to close the Amoret post office...

  3. 49 CFR 238.211 - Collision posts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... structural protection described in paragraph (a) of this section, either: (1) Two forward collision posts... structural protection described in paragraphs (a) and (b) of this section, two forward collision posts... body structure. (3) Prior to or during structural deformation, each collision post acting together...

  4. 36 CFR 261.51 - Posting.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Posting. 261.51 Section 261.51 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS Prohibitions in Areas Designated by Order § 261.51 Posting. Posting is accomplished by: (a) Placing a copy...

  5. 10 CFR 160.6 - Posting.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Posting. 160.6 Section 160.6 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) TRESPASSING ON COMMISSION PROPERTY § 160.6 Posting. Notices stating the pertinent prohibitions of §§ 160.3 and 160.4 and penalties of § 160.5 will be conspicuously posted at all entrances...

  6. 10 CFR 21.6 - Posting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Posting requirements. 21.6 Section 21.6 Energy NUCLEAR REGULATORY COMMISSION REPORTING OF DEFECTS AND NONCOMPLIANCE General Provisions § 21.6 Posting requirements... United States where the activities subject to this part are conducted. (b) If posting of the...

  7. 10 CFR 73.75 - Posting.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Posting. 73.75 Section 73.75 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PHYSICAL PROTECTION OF PLANTS AND MATERIALS Records and Reports § 73.75 Posting. (a... criminal penalties, and associated posting requirements, under section 229 of the Atomic Energy Act...

  8. 36 CFR 261.51 - Posting.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Posting. 261.51 Section 261.51 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROHIBITIONS Prohibitions in Areas Designated by Order § 261.51 Posting. Posting is accomplished by: (a) Placing a copy...

  9. 36 CFR 71.4 - Posting.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Posting. 71.4 Section 71.4 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR RECREATION FEES § 71.4 Posting. (a) The administering bureaus of the Department of the Interior shall provide for the posting of the following designation sign...

  10. 36 CFR 71.4 - Posting.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Posting. 71.4 Section 71.4 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR RECREATION FEES § 71.4 Posting. (a) The administering bureaus of the Department of the Interior shall provide for the posting of the following designation sign...

  11. 36 CFR 71.4 - Posting.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Posting. 71.4 Section 71.4 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR RECREATION FEES § 71.4 Posting. (a) The administering bureaus of the Department of the Interior shall provide for the posting of the following designation sign...

  12. 76 FR 72454 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-23

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Elmo, Missouri post office has been filed. It... received a petition for review of the Postal Service's determination to close the Elmo post office in...

  13. 76 FR 76443 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-07

    ... COMMISSION Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Greeley, Iowa post office has been filed. It... received a petition for review of the Postal Service's determination to close the Greeley post office...

  14. 76 FR 68232 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-03

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Ogden, Arkansas post office has been filed. It... received a petition for review of the Postal Service's determination to close the Ogden post office...

  15. 76 FR 76444 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-07

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Holland, Iowa post office has been filed. It... received a petition for review of the Postal Service's determination to close the Holland post office...

  16. 76 FR 72456 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-23

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Scottville, Illinois post office has been filed... received a petition for review of the Postal Service's determination to close the Scottville post office...

  17. 76 FR 76447 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-07

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Miller, Nebraska post office has been filed. It... received a petition for review of the Postal Service's determination to close the Miller post office...

  18. 76 FR 54511 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-01

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Lake Creek, Texas post office has been filed. It... Service's determination to close the Lake Creek post office in Lake Creek, Texas. The petitions were...

  19. 76 FR 54264 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-31

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Enloe, Texas post office has been filed. It... Postal Service's determination to close the Enloe post office in Enloe, Texas. The petitions were...

  20. 76 FR 76451 - Post Office Closing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-07

    ... Post Office Closing AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: This document informs the public that an appeal of the closing of the Nixon, Nevada post office has been filed. It... received a petition for review of the Postal Service's determination to close the Nixon post office...