Science.gov

Sample records for postulated initiating event

  1. The Annular Core Research Reactor (ACRR) postulated limiting event initial and building source terms

    SciTech Connect

    Restrepo, L F

    1992-08-01

    As part of the update of the Safety analysis Report (SAR) for the Annular Core Research Reactor (ACRR), operational limiting events under the category of inadvertent withdrawal of an experiment while at power or during a power pulse were determined to be the most limiting event(s) for this reactor. This report provides a summary of the assumptions, modeling, and results in evaluation of: Reactivity and thermal hydraulics analysis to determine the amount of fuel melt or fuel damage ratios; The reactor inventories following the limiting event; A literature review of post NUREG-0772 release fraction experiment results on severe fuel damages; Decontamination factors due to in-pool transport; and In-building transport modeling and building source term analysis.

  2. Risk assessment of K Basin twelve-inch and four-inch drain valve failure from a postulated seismic initiating event

    SciTech Connect

    MORGAN, R.G.

    1999-06-23

    The Spent Nuclear Fuel (SNF) Project will transfer metallic SNF from the Hanford 105 K-East and 105 K-West Basins to safe interim storage in the Canister Storage Building in the 200 Area. The initial basis for design, fabrication, installation, and operation of the fuel removal systems was that the basin leak rate which could result from a postulated accident condition would not be excessive relative to reasonable recovery operations. However, an additional potential K Basin water leak path is through the K Basin drain valves. Three twelve-inch drain valves are located in the main basin bays along the north wall. Five four-inch drain valves are located in the north and south loadout pits (NLOP and SLOP), the weasel pit, the technical viewing pit, and the discharge chute pit. The sumps containing the valves are filled with concrete which covers the drain valve body. Visual observations indicate that only the valve's bonnet and stem are exposed above the basin concrete floor for the twelve-inch drain valve and that much less of the valve's bonnet and stem are exposed above the basin concrete floor for the five four-inch drain valves. It was recognized, however, that damage of the drain valve bonnet or stem during a seismic initiating event could provide a potential K Basin water leak path. The objectives of this analysis are to: (1) evaluate the likelihood of damaging the three twelve-inch drain valves located along the north wall of the main basin and the five four-inch drain valves located in the pits from a seismic initiating event, and (2) determine the likelihood of exceeding a specific consequence (initial leak rate) from a damaged valve. The analysis process is a risk-based uncertainty analysis where each variable is modeled using available information and engineering judgement. The uncertainty associated with each variable is represented by a probability distribution (probability density function). Uncertainty exists because of the inherent randomness

  3. Westinghouse Small Modular Reactor passive safety system response to postulated events

    SciTech Connect

    Smith, M. C.; Wright, R. F.

    2012-07-01

    The Westinghouse Small Modular Reactor (SMR) is an 800 MWt (>225 MWe) integral pressurized water reactor. This paper is part of a series of four describing the design and safety features of the Westinghouse SMR. This paper focuses in particular upon the passive safety features and the safety system response of the Westinghouse SMR. The Westinghouse SMR design incorporates many features to minimize the effects of, and in some cases eliminates the possibility of postulated accidents. The small size of the reactor and the low power density limits the potential consequences of an accident relative to a large plant. The integral design eliminates large loop piping, which significantly reduces the flow area of postulated loss of coolant accidents (LOCAs). The Westinghouse SMR containment is a high-pressure, compact design that normally operates at a partial vacuum. This facilitates heat removal from the containment during LOCA events. The containment is submerged in water which also aides the heat removal and provides an additional radionuclide filter. The Westinghouse SMR safety system design is passive, is based largely on the passive safety systems used in the AP1000{sup R} reactor, and provides mitigation of all design basis accidents without the need for AC electrical power for a period of seven days. Frequent faults, such as reactivity insertion events and loss of power events, are protected by first shutting down the nuclear reaction by inserting control rods, then providing cold, borated water through a passive, buoyancy-driven flow. Decay heat removal is provided using a layered approach that includes the passive removal of heat by the steam drum and independent passive heat removal system that transfers heat from the primary system to the environment. Less frequent faults such as loss of coolant accidents are mitigated by passive injection of a large quantity of water that is readily available inside containment. An automatic depressurization system is used to

  4. RAS Initiative - Events

    Cancer.gov

    The NCI RAS Initiative has organized multiple events with outside experts to discuss how the latest scientific and technological breakthroughs can be applied to discover vulnerabilities in RAS-driven cancers.

  5. Initial Events in Bacterial Transcription Initiation

    PubMed Central

    Ruff, Emily F.; Record, M. Thomas; Artsimovitch, Irina

    2015-01-01

    Transcription initiation is a highly regulated step of gene expression. Here, we discuss the series of large conformational changes set in motion by initial specific binding of bacterial RNA polymerase (RNAP) to promoter DNA and their relevance for regulation. Bending and wrapping of the upstream duplex facilitates bending of the downstream duplex into the active site cleft, nucleating opening of 13 bp in the cleft. The rate-determining opening step, driven by binding free energy, forms an unstable open complex, probably with the template strand in the active site. At some promoters, this initial open complex is greatly stabilized by rearrangements of the discriminator region between the −10 element and +1 base of the nontemplate strand and of mobile in-cleft and downstream elements of RNAP. The rate of open complex formation is regulated by effects on the rapidly-reversible steps preceding DNA opening, while open complex lifetime is regulated by effects on the stabilization of the initial open complex. Intrinsic DNA opening-closing appears less regulated. This noncovalent mechanism and its regulation exhibit many analogies to mechanisms of enzyme catalysis. PMID:26023916

  6. Longitudinal hydrodynamics from event-by-event Landau initial conditions

    SciTech Connect

    Sen, Abhisek; Gerhard, Jochen; Torrieri, Giorgio; Read, Kenneth; Wong, Cheuk-Yin

    2015-02-02

    Here we investigate three-dimensional ideal hydrodynamic evolution, with Landau initial conditions, incorporating event-by-event variation with many events and transverse density inhomogeneities. We show that the transition to boost-invariant flow occurs too late for realistic setups, with corrections of θ (20%-30%) expected at freeze-out for most scenarios. Moreover, the deviation from boost invariance is correlated with both transverse flow and elliptic flow, with the more highly transversely flowing regions also showing the most violation of boost invariance. Therefore, if longitudinal flow is not fully developed at the early stages of heavy ion collisions, hydrodynamics where boost invariance holds at midrapidity is inadequate to extract transport coefficients of the quark-gluon plasma. We conclude by arguing that developing experimental probes of boost invariance is necessary, and suggest some promising directions in this regard.

  7. Longitudinal hydrodynamics from event-by-event Landau initial conditions

    DOE PAGES

    Sen, Abhisek; Gerhard, Jochen; Torrieri, Giorgio; ...

    2015-02-02

    Here we investigate three-dimensional ideal hydrodynamic evolution, with Landau initial conditions, incorporating event-by-event variation with many events and transverse density inhomogeneities. We show that the transition to boost-invariant flow occurs too late for realistic setups, with corrections of θ (20%-30%) expected at freeze-out for most scenarios. Moreover, the deviation from boost invariance is correlated with both transverse flow and elliptic flow, with the more highly transversely flowing regions also showing the most violation of boost invariance. Therefore, if longitudinal flow is not fully developed at the early stages of heavy ion collisions, hydrodynamics where boost invariance holds at midrapidity ismore » inadequate to extract transport coefficients of the quark-gluon plasma. We conclude by arguing that developing experimental probes of boost invariance is necessary, and suggest some promising directions in this regard.« less

  8. A review for identification of initiating events in event tree development process on nuclear power plants

    NASA Astrophysics Data System (ADS)

    Riyadi, Eko H.

    2014-09-01

    Initiating event is defined as any event either internal or external to the nuclear power plants (NPPs) that perturbs the steady state operation of the plant, if operating, thereby initiating an abnormal event such as transient or loss of coolant accident (LOCA) within the NPPs. These initiating events trigger sequences of events that challenge plant control and safety systems whose failure could potentially lead to core damage or large early release. Selection for initiating events consists of two steps i.e. first step, definition of possible events, such as by evaluating a comprehensive engineering, and by constructing a top level logic model. Then the second step, grouping of identified initiating event's by the safety function to be performed or combinations of systems responses. Therefore, the purpose of this paper is to discuss initiating events identification in event tree development process and to reviews other probabilistic safety assessments (PSA). The identification of initiating events also involves the past operating experience, review of other PSA, failure mode and effect analysis (FMEA), feedback from system modeling, and master logic diagram (special type of fault tree). By using the method of study for the condition of the traditional US PSA categorization in detail, could be obtained the important initiating events that are categorized into LOCA, transients and external events.

  9. A review for identification of initiating events in event tree development process on nuclear power plants

    SciTech Connect

    Riyadi, Eko H.

    2014-09-30

    Initiating event is defined as any event either internal or external to the nuclear power plants (NPPs) that perturbs the steady state operation of the plant, if operating, thereby initiating an abnormal event such as transient or loss of coolant accident (LOCA) within the NPPs. These initiating events trigger sequences of events that challenge plant control and safety systems whose failure could potentially lead to core damage or large early release. Selection for initiating events consists of two steps i.e. first step, definition of possible events, such as by evaluating a comprehensive engineering, and by constructing a top level logic model. Then the second step, grouping of identified initiating event's by the safety function to be performed or combinations of systems responses. Therefore, the purpose of this paper is to discuss initiating events identification in event tree development process and to reviews other probabilistic safety assessments (PSA). The identification of initiating events also involves the past operating experience, review of other PSA, failure mode and effect analysis (FMEA), feedback from system modeling, and master logic diagram (special type of fault tree). By using the method of study for the condition of the traditional US PSA categorization in detail, could be obtained the important initiating events that are categorized into LOCA, transients and external events.

  10. Radiological Impact Assessment (RIA) following a postulated accident in PHWRS

    SciTech Connect

    Soni, N.; Kansal, M.; Rammohan, H. P.; Malhotra, P. K.

    2012-07-01

    Radiological Impact Assessment (RIA) following postulated accident i.e Loss of Coolant Accident (LOCA) with failed Emergency Core Cooling System (ECCS), performed as part of the reactor safety analysis of a typical 700 MWe Indian Pressurized Heavy Water Reactor(PHWR). The rationale behind the assessment is that the public needs to be protected in the event that the postulated accident results in radionuclide release outside containment. Radionuclides deliver dose to the human body through various pathways namely, plume submersion, exposure due to ground deposition, inhalation and ingestion. The total exposure dose measured in terms of total effective dose equivalent (TEDE) is the sum of doses to a hypothetical adult human at exclusion zone boundary by all the exposure pathways. The analysis provides the important inputs to decide upon the type of emergency counter measures to be adopted during the postulated accident. The importance of the various pathways in terms of contribution to the total effective dose equivalent(TEDE) is also assessed with respect to time of exposure. Inhalation and plume gamma dose are the major contributors towards TEDE during initial period of accident whereas ingestion and ground shine dose start dominating in TEDE in the extended period of exposure. Moreover, TEDE is initially dominated by I-131, Kr-88, Te-132, I-133 and Sr-89, whereas, as time progresses, Xe-133,I-131 and Te-132 become the main contributors. (authors)

  11. Preliminary Identification of Accident Initiating Events for IFE Power Plants

    SciTech Connect

    Cadwallader, Lee Charles; Latkowsk, J. F.

    2001-10-01

    This paper presents initial results of a task to identify accident initiating events for inertial fusion energy (IFE) power plant designs. Initiating events (IEs) are a fundamental building block of a probabilistic risk assessment; they are the ‘accident starters’ that are analyzed to determine the risks posed to members of the public in the vicinity of the power plant. The IE results for the SOMBRERO design are presented in tabular form. The SOMBRERO design was analyzed since it is representative of dry chamber wall, laser driven designs. This work is used to characterize IFE plant risk and to identify potential design changes that would mitigate the plant risk.

  12. Bayes' postulate for trinomial trials

    NASA Astrophysics Data System (ADS)

    Diniz, M. A.; Polpo, A.

    2012-10-01

    In this paper, we discuss Bayes' postulate and its interpretation. We extend the binomial trial method proposed by de Finetti [1] to trinomial trials, for which we argue that the consideration of equiprobability a priori for the possible outcomes of the trinomial trials implies that the parameter vector has Dirichlet(1,1) as prior. Based on this result, we agree with Stigler [2] in that the notion in Bayes' postulate stating "absolutely know nothing" is related to the possible outcomes of an experiment and not to "non-information" about the parameter.

  13. Initial Time Dependence of Abundances in Solar Energetic Particle Events

    NASA Technical Reports Server (NTRS)

    Reames, Donald V.; Ny, C. K.; Tylka, A. J.

    1999-01-01

    We compare the initial behavior of Fe/O and He/H abundance ratios and their relationship to the evolution of the proton energy spectra in "small" and "large" gradual solar energetic particle (SEP) events. The results are qualitatively consistent with the behavior predicted by the theory of Ng et al. (1999a, b). He/H ratios that initially rise with time are a signature of scattering by non-Kolmogorov Alfven wave spectra generated by intense beams of shock-accelerated protons streaming outward in large gradual SEP events.

  14. QUANTUM MECHANICS WITHOUT STATISTICAL POSTULATES

    SciTech Connect

    G. GEIGER; ET AL

    2000-11-01

    The Bohmian formulation of quantum mechanics describes the measurement process in an intuitive way without a reduction postulate. Due to the chaotic motion of the hidden classical particle all statistical features of quantum mechanics during a sequence of repeated measurements can be derived in the framework of a deterministic single system theory.

  15. Initiating Events for Multi-Reactor Plant Sites

    SciTech Connect

    Muhlheim, Michael David; Flanagan, George F.; Poore, III, Willis P.

    2014-09-01

    Inherent in the design of modular reactors is the increased likelihood of events that initiate at a single reactor affecting another reactor. Because of the increased level of interactions between reactors, it is apparent that the Probabilistic Risk Assessments (PRAs) for modular reactor designs need to specifically address the increased interactions and dependencies.

  16. Sensitivity of a Simulated Derecho Event to Model Initial Conditions

    NASA Astrophysics Data System (ADS)

    Wang, Wei

    2014-05-01

    Since 2003, the MMM division at NCAR has been experimenting cloud-permitting scale weather forecasting using Weather Research and Forecasting (WRF) model. Over the years, we've tested different model physics, and tried different initial and boundary conditions. Not surprisingly, we found that the model's forecasts are more sensitive to the initial conditions than model physics. In 2012 real-time experiment, WRF-DART (Data Assimilation Research Testbed) at 15 km was employed to produce initial conditions for twice-a-day forecast at 3 km. On June 29, this forecast system captured one of the most destructive derecho event on record. In this presentation, we will examine forecast sensitivity to different model initial conditions, and try to understand the important features that may contribute to the success of the forecast.

  17. Stochastic trajectories of succession initiated by extreme climatic events.

    PubMed

    Kreyling, J; Jentsch, A; Beierkuhnlein, C

    2011-08-01

    Deterministic or rule-based succession is expected under homogeneous biotic and abiotic starting conditions. Effects of extreme climatic events such as drought, however, may alter these assembly rules by adding stochastic elements. We monitored the succession of species composition of 30 twin grassland communities with identical biotic and abiotic starting conditions in an initially sown diversity gradient between 1 and 16 species over 13 years. The stochasticity of succession, measured as the synchrony in the development of the species compositions of the twin plots, was strongly altered by the extreme warm and dry summer of 2003. Moreover, it was independent from past and present plant diversity and neighbourhood species compositions. Extreme climatic events can induce stochastic effects in community development and therefore impair predictability even under homogeneous abiotic conditions. Stochastic events may result in lasting shifts of community composition, as well as adverse and unforeseeable effects on the stability of ecological services.

  18. Performance bounds on parallel self-initiating discrete-event

    NASA Technical Reports Server (NTRS)

    Nicol, David M.

    1990-01-01

    The use is considered of massively parallel architectures to execute discrete-event simulations of what is termed self-initiating models. A logical process in a self-initiating model schedules its own state re-evaluation times, independently of any other logical process, and sends its new state to other logical processes following the re-evaluation. The interest is in the effects of that communication on synchronization. The performance is considered of various synchronization protocols by deriving upper and lower bounds on optimal performance, upper bounds on Time Warp's performance, and lower bounds on the performance of a new conservative protocol. The analysis of Time Warp includes the overhead costs of state-saving and rollback. The analysis points out sufficient conditions for the conservative protocol to outperform Time Warp. The analysis also quantifies the sensitivity of performance to message fan-out, lookahead ability, and the probability distributions underlying the simulation.

  19. Nonlinear damage analysis: Postulate and evaluation

    NASA Technical Reports Server (NTRS)

    Leis, B. N.; Forte, T. P.

    1983-01-01

    The objective of this program is to assess the viability of a damage postulate which asserts that the fatigue resistance curve of a metal is history dependent due to inelastic action. The study focusses on OFE copper because this simple model material accentuates the inelastic action central to the damage postulate. Data relevant to damage evolution and crack initiation are developed via a study of surface topography. The effects of surface layer residual stresses are explored via comparative testing as were the effects in initial prestraining. The results of the study very clearly show the deformation history dependence of the fatigue resistance of OFE copper. Furthermore the concept of deformation history dependence is shown to qualitatively explain the fatigue resistance of all histories considered. Likewise quantitative predictions for block cycle histories are found to accurately track the observed results. In this respect the assertion that damage per cycle for a given level of the damage parameter is deformation history dependent appears to be physically justified.

  20. Signaling events during initiation of arbuscular mycorrhizal symbiosis.

    PubMed

    Schmitz, Alexa M; Harrison, Maria J

    2014-03-01

    Under nutrient-limiting conditions, plants will enter into symbiosis with arbuscular mycorrhizal (AM) fungi for the enhancement of mineral nutrient acquisition from the surrounding soil. AM fungi live in close, intracellular association with plant roots where they transfer phosphate and nitrogen to the plant in exchange for carbon. They are obligate fungi, relying on their host as their only carbon source. Much has been discovered in the last decade concerning the signaling events during initiation of the AM symbiosis, including the identification of signaling molecules generated by both partners. This signaling occurs through symbiosis-specific gene products in the host plant, which are indispensable for normal AM development. At the same time, plants have adapted complex mechanisms for avoiding infection by pathogenic fungi, including an innate immune response to general microbial molecules, such as chitin present in fungal cell walls. How it is that AM fungal colonization is maintained without eliciting a defensive response from the host is still uncertain. In this review, we present a summary of the molecular signals and their elicited responses during initiation of the AM symbiosis, including plant immune responses and their suppression.

  1. First Steps: Initial Information and Communication Technology (ICT) Events.

    ERIC Educational Resources Information Center

    Clarke, Alan

    This document is intended to assist practitioners who are designing and organizing an initial information and communication technology (ICT) experience for adult learners. Section 1 presents an overview of the initial ICT learning experience. The concept of transferable skills is discussed in the context of ICT in Section 2. Section 3 explains new…

  2. Everlasting initial memory threshold for rare events in equilibration processes.

    PubMed

    Lee, J S; Kwon, Chulan; Park, Hyunggyu

    2013-02-01

    Conventional wisdom indicates that initial memory should decay away exponentially in time for general (noncritial) equilibration processes. In particular, time-integrated quantities such as heat are presumed to lose initial memory in a sufficiently long-time limit. However, we show that the large deviation function of time-integrated quantities may exhibit initial memory effect even in the infinite-time limit, if the system is initially prepared sufficiently far away from equilibrium. For a Brownian particle dynamics, as an example, we found a sharp finite threshold rigorously, beyond which the corresponding large deviation function contains everlasting initial memory. The physical origin for this phenomenon is explored with an intuitive argument and also from a toy model analysis. Our results can be applied to general nonequilibrium relaxation processes reaching (non)equilibrium steady states.

  3. Quality Improvement Initiative Reduces Serious Safety Events in Pediatric Hospital Patients

    MedlinePlus

    ... Annual Conferences Newsletter AHRQ News Now Search News & Events Topics Search ahrq.gov About About AHRQ Profile ... May 2013 Quality improvement initiative reduces serious safety events in pediatric hospital patients Previous Page Next Page ...

  4. Initiating Event Rates at U.S. Nuclear Power Plants. 1988 - 2013

    SciTech Connect

    Schroeder, John A.; Bower, Gordon R.

    2014-02-01

    Analyzing initiating event rates is important because it indicates performance among plants and also provides inputs to several U.S. Nuclear Regulatory Commission (NRC) risk-informed regulatory activities. This report presents an analysis of initiating event frequencies at U.S. commercial nuclear power plants since each plant’s low-power license date. The evaluation is based on the operating experience from fiscal year 1988 through 2013 as reported in licensee event reports. Engineers with nuclear power plant experience staff reviewed each event report since the last update to this report for the presence of valid scrams or reactor trips at power. To be included in the study, an event had to meet all of the following criteria: includes an unplanned reactor trip (not a scheduled reactor trip on the daily operations schedule), sequence of events starts when reactor is critical and at or above the point of adding heat, occurs at a U.S. commercial nuclear power plant (excluding Fort St. Vrain and LaCrosse), and is reported by a licensee event report. This report displays occurrence rates (baseline frequencies) for the categories of initiating events that contribute to the NRC’s Industry Trends Program. Sixteen initiating event groupings are trended and displayed. Initiators are plotted separately for initiating events with different occurrence rates for boiling water reactors and pressurized water reactors. p-values are given for the possible presence of a trend over the most recent 10 years.

  5. 75 FR 38078 - Manufacturing and Services' Manufacture America Initiative and Events

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-01

    ... International Trade Administration Manufacturing and Services' Manufacture America Initiative and Events ACTION: Notice of series of regional events and supportive resources to promote growth and retooling in.... manufacturers' needs will be available at each event. FOR FURTHER INFORMATION CONTACT: Bruce Harsh at...

  6. Biologically induced initiation of Neoproterozoic snowball-Earth events.

    PubMed

    Tziperman, Eli; Halevy, Itay; Johnston, David T; Knoll, Andrew H; Schrag, Daniel P

    2011-09-13

    The glaciations of the Neoproterozoic Era (1,000 to 542 MyBP) were preceded by dramatically light C isotopic excursions preserved in preglacial deposits. Standard explanations of these excursions involve remineralization of isotopically light organic matter and imply strong enhancement of atmospheric CO(2) greenhouse gas concentration, apparently inconsistent with the glaciations that followed. We examine a scenario in which the isotopic signal, as well as the global glaciation, result from enhanced export of organic matter from the upper ocean into anoxic subsurface waters and sediments. The organic matter undergoes anoxic remineralization at depth via either sulfate- or iron-reducing bacteria. In both cases, this can lead to changes in carbonate alkalinity and dissolved inorganic pool that efficiently lower the atmospheric CO(2) concentration, possibly plunging Earth into an ice age. This scenario predicts enhanced deposition of calcium carbonate, the formation of siderite, and an increase in ocean pH, all of which are consistent with recent observations. Late Neoproterozoic diversification of marine eukaryotes may have facilitated the episodic enhancement of export of organic matter from the upper ocean, by causing a greater proportion of organic matter to be partitioned as particulate aggregates that can sink more efficiently, via increased cell size, biomineralization or increased CN of eukaryotic phytoplankton. The scenario explains isotopic excursions that are correlated or uncorrelated with snowball initiation, and suggests that increasing atmospheric oxygen concentrations and a progressive oxygenation of the subsurface ocean helped to prevent snowball glaciation on the Phanerozoic Earth.

  7. Effect of Two Different Methods of Initiating Atomoxetine on the Adverse Event Profile of Atomoxetine

    ERIC Educational Resources Information Center

    Greenhill, Laurence L.; Newcorn, Jeffrey H.; Gao, Haitao; Feldman, Peter D.

    2007-01-01

    Objective: To compare the effects of two different methods for initiating atomoxetine in terms of the incidence of early adverse events. Method: Data on atomoxetine treatment-emergent adverse events in youths, ages 6 to 18 years, were analyzed from five randomized, double-blind, placebo-controlled, acute-phase studies. Two studies involve…

  8. Postulated accident scenarios in weapons disassembly

    SciTech Connect

    Payne, S.S.

    1997-06-01

    A very brief summary of three postulated accident scenarios for weapons disassembly is provided in the paper. The first deals with a tetrahedral configuration of four generic pits; the second, an infinite planar array of generic pits with varying interstitial water density; and the third, a spherical shell with internal mass suspension in water varying the size and mass of the shell. Calculations were performed using the Monte Carlo Neutron Photon transport code MCNP4A. Preliminary calculations pointed to a need for higher resolution of small pit separation regimes and snapshots of hydrodynamic processes of water/plutonium mixtures.

  9. Observations of narrow bipolar events reveal how lightning is initiated in thunderstorms.

    PubMed

    Rison, William; Krehbiel, Paul R; Stock, Michael G; Edens, Harald E; Shao, Xuan-Min; Thomas, Ronald J; Stanley, Mark A; Zhang, Yang

    2016-02-15

    A long-standing but fundamental question in lightning studies concerns how lightning is initiated inside storms, given the absence of physical conductors. The issue has revolved around the question of whether the discharges are initiated solely by conventional dielectric breakdown or involve relativistic runaway electron processes. Here we report observations of a relatively unknown type of discharge, called fast positive breakdown, that is the cause of high-power discharges known as narrow bipolar events. The breakdown is found to have a wide range of strengths and is the initiating event of numerous lightning discharges. It appears to be purely dielectric in nature and to consist of a system of positive streamers in a locally intense electric field region. It initiates negative breakdown at the starting location of the streamers, which leads to the ensuing flash. The observations show that many or possibly all lightning flashes are initiated by fast positive breakdown.

  10. Observations of narrow bipolar events reveal how lightning is initiated in thunderstorms

    SciTech Connect

    Rison, William; Krehbiel, Paul R.; Stock, Michael G.; Edens, Harald E.; Shao, Xuan-Min; Thomas, Ronald J.; Stanley, Mark A.; Zhang, Yang

    2016-02-15

    A long-standing but fundamental question in lightning studies concerns how lightning is initiated inside storms, given the absence of physical conductors. The issue has revolved around the question of whether the discharges are initiated solely by conventional dielectric breakdown or involve relativistic runaway electron processes. Here we report observations of a relatively unknown type of discharge, called fast positive breakdown, that is the cause of high-power discharges known as narrow bipolar events. We find that the breakdown has a wide range of strengths and is the initiating event of numerous lightning discharges. It appears to be purely dielectric in nature and to consist of a system of positive streamers in a locally intense electric field region. It initiates negative breakdown at the starting location of the streamers, which leads to the ensuing flash. The observations show that many or possibly all lightning flashes are initiated by fast positive breakdown.

  11. Observations of narrow bipolar events reveal how lightning is initiated in thunderstorms

    PubMed Central

    Rison, William; Krehbiel, Paul R.; Stock, Michael G.; Edens, Harald E.; Shao, Xuan-Min; Thomas, Ronald J.; Stanley, Mark A.; Zhang, Yang

    2016-01-01

    A long-standing but fundamental question in lightning studies concerns how lightning is initiated inside storms, given the absence of physical conductors. The issue has revolved around the question of whether the discharges are initiated solely by conventional dielectric breakdown or involve relativistic runaway electron processes. Here we report observations of a relatively unknown type of discharge, called fast positive breakdown, that is the cause of high-power discharges known as narrow bipolar events. The breakdown is found to have a wide range of strengths and is the initiating event of numerous lightning discharges. It appears to be purely dielectric in nature and to consist of a system of positive streamers in a locally intense electric field region. It initiates negative breakdown at the starting location of the streamers, which leads to the ensuing flash. The observations show that many or possibly all lightning flashes are initiated by fast positive breakdown. PMID:26876654

  12. Observations of narrow bipolar events reveal how lightning is initiated in thunderstorms

    DOE PAGES

    Rison, William; Krehbiel, Paul R.; Stock, Michael G.; ...

    2016-02-15

    A long-standing but fundamental question in lightning studies concerns how lightning is initiated inside storms, given the absence of physical conductors. The issue has revolved around the question of whether the discharges are initiated solely by conventional dielectric breakdown or involve relativistic runaway electron processes. Here we report observations of a relatively unknown type of discharge, called fast positive breakdown, that is the cause of high-power discharges known as narrow bipolar events. We find that the breakdown has a wide range of strengths and is the initiating event of numerous lightning discharges. It appears to be purely dielectric in naturemore » and to consist of a system of positive streamers in a locally intense electric field region. It initiates negative breakdown at the starting location of the streamers, which leads to the ensuing flash. The observations show that many or possibly all lightning flashes are initiated by fast positive breakdown.« less

  13. Development of transient initiating event frequencies for use in probabilistic risk assessments

    SciTech Connect

    Mackowiak, D.P.; Gentillon, C.D.; Smith, K.L.

    1985-05-01

    Transient initiating event frequencies are an essential input to the analysis process of a nuclear power plant probabilistic risk assessment. These frequencies describe events causing or requiring scrams. This report documents an effort to validate and update from other sources a computer-based data file developed by the Electric Power Research Institute (EPRI) describing such events at 52 United States commercial nuclear power plants. Operating information from the United States Nuclear Regulatory Commission on 24 additional plants from their date of commercial operation has been combined with the EPRI data, and the entire data base has been updated to add 1980 through 1983 events for all 76 plants. The validity of the EPRI data and data analysis methodology and the adequacy of the EPRI transient categories are examined. New transient initiating event frequencies are derived from the expanded data base using the EPRI transient categories and data display methods. Upper bounds for these frequencies are also provided. Additional analyses explore changes in the dominant transients, changes in transient outage times and their impact on plant operation, and the effects of power level and scheduled scrams on transient event frequencies. A more rigorous data analysis methodology is developed to encourage further refinement of the transient initiating event frequencies derived herein. Updating the transient event data base resulted in approx.2400 events being added to EPRI's approx.3000-event data file. The resulting frequency estimates were in most cases lower than those reported by EPRI, but no significant order-of-magnitude changes were noted. The average number of transients per year for the combined data base is 8.5 for pressurized water reactors and 7.4 for boiling water reactors.

  14. Development of a tiered screening strategy for a molecular-initiating event: thyroperoxidase inhibition (SOT)

    EPA Science Inventory

    Adverse outcome pathway (AOP) analyses illustrate that some molecular-initiating events (MIEs) for thyroid disruption, including thyroperoxidase (TPO) inhibition, are not evaluated by current ToxCast/Tox21 high-throughput screening (HTS) assays. A novel HTS assay for TPO inhibiti...

  15. Understanding initiation and termination events in the primary amine-initiated polymerization of NCAs by high-vacuum techniques

    SciTech Connect

    Pickel, Deanna L; Messman, Jamie M

    2010-01-01

    High-vacuum polymerization of -amino acid-N-carboxyanhydrides (NCAs) affords polymers with controlled molecular weights and narrow polydispersities, however a comprehensive study of the end-group composition of the resulting polypeptides has not yet been performed. This reveals crucial information, as the end-groups are indicative of both the polymerization mechanism (i.e., initiation event) as well as the termination pathways. To this end, poly(O-benzyl-L-tyrosine) initiated by 1,6-diaminohexane was synthesized and subsequently characterized by MALDI-TOF MS, NALDI -TOF MS and 13C NMR spectroscopy to ascertain the end-group structure. Polymers were prepared by both high vacuum and glove box techniques in DMF/THF. Preparation of poly(O-benzyl-L-tyrosine) by high vacuum techniques yielded a polymer initiated exclusively by the normal amine mechanism, and termination by reaction with DMF was observed. In contrast, polymers prepared in the glove box were initiated by the normal amine and activated monomer mechanisms, and several termination products are evident. To our knowledge, this is the first rigorous and comparative analysis of the end-group structure, and it demonstrates the advantage of high vacuum techniques for polymerization of NCAs for the preparation of well-defined polypeptides with end-group fidelity.

  16. DNA Replication Origin Interference Increases the Spacing between Initiation Events in Human Cells

    PubMed Central

    Lebofsky, Ronald; Heilig, Roland; Sonnleitner, Max; Weissenbach, Jean

    2006-01-01

    Mammalian DNA replication origins localize to sites that range from base pairs to tens of kilobases. A regular distribution of initiations in individual cell cycles suggests that only a limited number of these numerous potential start sites are converted into activated origins. Origin interference can silence redundant origins; however, it is currently unknown whether interference participates in spacing functional human initiation events. By using a novel hybridization strategy, genomic Morse code, on single combed DNA molecules from primary keratinocytes, we report the initiation sites present on 1.5 Mb of human chromosome 14q11.2. We confirm that initiation zones are widespread in human cells, map to intergenic regions, and contain sequence motifs found at other mammalian initiation zones. Origins used per cell cycle are less abundant than the potential sites of initiation, and their limited use increases the spacing between initiation events. Between-zone interference decreases in proportion to the distance from the active origin, whereas within-zone interference is 100% efficient. These results identify a hierarchical organization of origin activity in human cells. Functional origins govern the probability that nearby origins will fire in the context of multiple potential start sites of DNA replication, and this is mediated by origin interference. PMID:17005913

  17. Meteorological factors and timing of the initiating event of human parturition

    NASA Astrophysics Data System (ADS)

    Hirsch, Emmet; Lim, Courtney; Dobrez, Deborah; Adams, Marci G.; Noble, William

    2011-03-01

    The aim of this study was to determine whether meteorological factors are associated with the timing of either onset of labor with intact membranes or rupture of membranes prior to labor—together referred to as `the initiating event' of parturition. All patients delivering at Evanston Hospital after spontaneous labor or rupture of membranes at ≥20 weeks of gestation over a 6-month period were studied. Logistic regression models of the initiating event of parturition using clinical variables (maternal age, gestational age, parity, multiple gestation and intrauterine infection) with and without the addition of meteorological variables (barometric pressure, temperature and humidity) were compared. A total of 1,088 patients met the inclusion criteria. Gestational age, multiple gestation and chorioamnionitis were associated with timing of initiation of parturition ( P < 0.01). The addition of meteorological to clinical variables generated a statistically significant improvement in prediction of the initiating event; however, the magnitude of this improvement was small (less than 2% difference in receiver-operating characteristic score). These observations held regardless of parity, fetal number and gestational age. Meteorological factors are associated with the timing of parturition, but the magnitude of this association is small.

  18. Modeling a molecular initiating event to population effects: A case study of aromatase inhibition in fathead minnows

    EPA Science Inventory

    An adverse outcome pathway (AOP) conceptually links a molecular initiating event with measureable key events at higher levels of biological organization that ultimately result in an adverse outcome. Development of an AOP requires experimental data and scientific expertise to ide...

  19. Physical mechanism of initial breakdown pulses and narrow bipolar events in lightning discharges

    NASA Astrophysics Data System (ADS)

    Silva, Caitano L.; Pasko, Victor P.

    2015-05-01

    To date the true nature of initial breakdown pulses (IBPs) and narrow bipolar events (NBEs) in lightning discharges remains a mystery. Recent experimental evidence has correlated IBPs to the initial development of lightning leaders inside the thundercloud. NBE wideband waveforms resemble classic IBPs in both amplitude and duration. Most NBEs are quite peculiar in the sense that very frequently they occur in isolation from other lightning processes. The remaining fraction, 16% of positive polarity NBEs, according to Wu et al. (2014), happens as the first event in an otherwise regular intracloud lightning discharge. These authors point out that the initiator type of NBEs has no difference with other NBEs that did not start lightning, except for the fact that they occur deeper inside the thunderstorm (i.e., at lower altitudes). In this paper, we propose a new physical mechanism to explain the source of both IBPs and NBEs. We propose that IBPs and NBEs are the electromagnetic transients associated with the sudden (i.e., stepwise) elongation of the initial negative leader extremity in the thunderstorm electric field. To demonstrate our hypothesis a novel computational/numerical model of the bidirectional lightning leader tree is developed, consisting of a generalization of electrostatic and transmission line approximations found in the literature. Finally, we show how the IBP and NBE waveform characteristics directly reflect the properties of the bidirectional lightning leader (such as step length, for example) and amplitude of the thunderstorm electric field.

  20. The "Big Bang" in obese fat: Events initiating obesity-induced adipose tissue inflammation.

    PubMed

    Wensveen, Felix M; Valentić, Sonja; Šestan, Marko; Turk Wensveen, Tamara; Polić, Bojan

    2015-09-01

    Obesity is associated with the accumulation of pro-inflammatory cells in visceral adipose tissue (VAT), which is an important underlying cause of insulin resistance and progression to diabetes mellitus type 2 (DM2). Although the role of pro-inflammatory cytokines in disease development is established, the initiating events leading to immune cell activation remain elusive. Lean adipose tissue is predominantly populated with regulatory cells, such as eosinophils and type 2 innate lymphocytes. These cells maintain tissue homeostasis through the excretion of type 2 cytokines, such as IL-4, IL-5, and IL-13, which keep adipose tissue macrophages (ATMs) in an anti-inflammatory, M2-like state. Diet-induced obesity is associated with the loss of tissue homeostasis and development of type 1 inflammatory responses in VAT, characterized by IFN-γ. A key event is a shift of ATMs toward an M1 phenotype. Recent studies show that obesity-induced adipocyte hypertrophy results in upregulated surface expression of stress markers. Adipose stress is detected by local sentinels, such as NK cells and CD8(+) T cells, which produce IFN-γ, driving M1 ATM polarization. A rapid accumulation of pro-inflammatory cells in VAT follows, leading to inflammation. In this review, we provide an overview of events leading to adipose tissue inflammation, with a special focus on adipose homeostasis and the obesity-induced loss of homeostasis which marks the initiation of VAT inflammation.

  1. Evaluating MJO event initiation and decay in the skeleton model using an RMM-like index

    NASA Astrophysics Data System (ADS)

    Stachnik, Justin P.; Waliser, Duane E.; Majda, Andrew J.; Stechmann, Samuel N.; Thual, Sulian

    2015-11-01

    The Madden-Julian oscillation (MJO) skeleton model is a low-order dynamic model that is capable of simulating many of the observed features of the MJO. This study develops a model-based "MJO" index that is similar to the well-known real-time multivariate MJO (RMM) index to better facilitate comparison between the skeleton model and observational data. Multivariate and univariate empirical orthogonal function (EOF) analyses were performed on the convective heating and zonal wind data taken from the skeleton model for simulations forced with an idealized warm pool and observed sea surface temperatures (SSTs). The leading EOF modes indicated a wave number 1 convectively coupled circulation anomaly with zonal asymmetries that closely resembled the observed RMM EOFs, especially when the model was forced with observed SSTs. The RMM-like index was used to compute an MJO climatology and document the occurrence of primary, continuing, and terminating MJO events in the skeleton model. The overall amount of MJO activity and event lengths compared reasonably well to observations for such a simple model. Attempts at reconciling the observed geographic distribution of individual MJO initiation and termination events were not successful for the stochastic simulations, though stochasticity is necessary in order to produce composite MJOs that initiate and decay with time scales similar to observations. Finally, analysis indicates that the existence of slow-moving, eastward traveling waves with higher wave numbers (k ≈ 12) embedded within the large-scale flow often precedes MJO termination in the skeleton model.

  2. Complex Events Initiated by Individual Spikes in the Human Cerebral Cortex

    PubMed Central

    Komlósi, Gergely; Füle, Miklós; Szabadics, János; Varga, Csaba; Barzó, Pál; Tamás, Gábor

    2008-01-01

    Synaptic interactions between neurons of the human cerebral cortex were not directly studied to date. We recorded the first dataset, to our knowledge, on the synaptic effect of identified human pyramidal cells on various types of postsynaptic neurons and reveal complex events triggered by individual action potentials in the human neocortical network. Brain slices were prepared from nonpathological samples of cortex that had to be removed for the surgical treatment of brain areas beneath association cortices of 58 patients aged 18 to 73 y. Simultaneous triple and quadruple whole-cell patch clamp recordings were performed testing mono- and polysynaptic potentials in target neurons following a single action potential fired by layer 2/3 pyramidal cells, and the temporal structure of events and underlying mechanisms were analyzed. In addition to monosynaptic postsynaptic potentials, individual action potentials in presynaptic pyramidal cells initiated long-lasting (37 ± 17 ms) sequences of events in the network lasting an order of magnitude longer than detected previously in other species. These event series were composed of specifically alternating glutamatergic and GABAergic postsynaptic potentials and required selective spike-to-spike coupling from pyramidal cells to GABAergic interneurons producing concomitant inhibitory as well as excitatory feed-forward action of GABA. Single action potentials of human neurons are sufficient to recruit Hebbian-like neuronal assemblies that are proposed to participate in cognitive processes. PMID:18767905

  3. Anomalous Java cooling at the initiation of positive Indian Ocean Dipole events

    NASA Astrophysics Data System (ADS)

    Delman, Andrew S.; Sprintall, Janet; McClean, Julie L.; Talley, Lynne D.

    2016-08-01

    Anomalous sea surface temperature (SST) cooling south of Java, initiated during May-July, is an important precursor to positive Indian Ocean Dipole (pIOD) events. As shown previously, the Java SST anomalies are spatially and temporally coincident with seasonal upwelling induced locally by southeasterly trade winds. However, we confirm earlier findings that interannual variability of the Java cooling is primarily driven by remote wind forcing from coastal Sumatra and the equatorial Indian Ocean (EqIO); we also find an influence from winds along the Indonesian Throughflow. The wind forcing in the EqIO and along coastal Sumatra does not initiate SST cooling locally due to a deep thermocline and thick barrier layer, but can force upwelling Kelvin waves that induce substantial surface cooling once they reach the seasonally shallower thermocline near the coast of Java. Satellite altimetry is used to obtain a Kelvin wave coefficient that approximates Kelvin wave amplitude variations along the equator. All pIOD years in the satellite record have anomalous levels of upwelling Kelvin wave activity along the equator during April-June, suggesting that upwelling waves during this season are necessary for pIOD event development. However, a change to wind-forced downwelling Kelvin waves during July-August can abruptly terminate cool Java SST anomalies and weaken the pIOD event. Upwelling Kelvin wave activity along the equator and wind stress anomalies west of Sumatra are both robust predictors of the IOD index later in the calendar year, while values of the Kelvin wave coefficient are the most reliable predictor of pIOD events specifically.

  4. Prospective Association Between Negative Life Events and Initiation of Sexual Intercourse: The Influence of Family Structure and Family Income

    PubMed Central

    Oman, Roy F.; Vesely, Sara K.; Aspy, Cheryl B.; Tolma, Eleni L.; John, Robert

    2015-01-01

    Objectives. We examined the prospective association between negative life events and time to initiation of sexual intercourse and the influence of family structure and family income on this association. Methods. We followed up a randomly selected sample (n = 649) of ethnically diverse parents and their children aged 12 to 17 years over a 5-year period. We conducted Cox proportional hazards regression analysis to examine the relation between negative life events and time to initiation of sexual intercourse. Family structure and family income were assessed as confounders. Results. Negative life events were significant predictors of time to initiation of sexual intercourse in adolescents. After controlling for demographic variables, youths reporting 1 negative life event had a hazard of initiation of sexual intercourse 1.40 times greater and youths reporting 2 or more negative life events had a hazard of initiation of sexual intercourse 1.61 times greater compared with youths reporting no negative life events. Family structure and family income were not significant confounders of the relation between initiation of sexual intercourse and negative life events. Conclusions. Interventions to prevent initiation of sexual intercourse should focus on youths with recent negative life events, regardless of family income and structure. PMID:25602885

  5. Repression of early lateral root initiation events by transient water deficit in barley and maize

    PubMed Central

    Babé, Aurélie; Lavigne, Tristan; Séverin, Jean-Philippe; Nagel, Kerstin A.; Walter, Achim; Chaumont, François; Batoko, Henri; Beeckman, Tom; Draye, Xavier

    2012-01-01

    The formation of lateral roots (LRs) is a key driver of root system architecture and developmental plasticity. The first stage of LR formation, which leads to the acquisition of founder cell identity in the pericycle, is the primary determinant of root branching patterns. The fact that initiation events occur asynchronously in a very small number of cells inside the parent root has been a major difficulty in the study of the molecular regulation of branching patterns. Inducible systems that trigger synchronous lateral formation at predictable sites have proven extremely valuable in Arabidopsis to decipher the first steps of LR formation. Here, we present a LR repression system for cereals that relies on a transient water-deficit treatment, which blocks LR initiation before the first formative divisions. Using a time-lapse approach, we analysed the dynamics of this repression along growing roots and were able to show that it targets a very narrow developmental window of the initiation process. Interestingly, the repression can be exploited to obtain negative control root samples where LR initiation is absent. This system could be instrumental in the analysis of the molecular basis of drought-responsive as well as intrinsic pathways of LR formation in cereals. PMID:22527396

  6. Examination of loop-operator-initiated events for the advanced test reactor

    SciTech Connect

    Durney, J.L.; Majumdar, D.

    1989-01-01

    The Advanced Test Reactor (ATR) located at the Idaho National Engineering Laboratory is a unique high-flux test reactor having nine major test positions for irradiation of reactor materials. These test positions contain inpile tubes (IPT) that are connected to external piping and equipment (loops) to provide the high-temperature, high-pressure environment for the testing. The design of the core has intimately integrated the IPTs into the fuel region by means of a serpentine fuel arrangement resulting in a close reactivity coupling between the loop thermal hydraulics and the core. Consequently, operator actions potentially have an impact on the reactor power transients resulting from off-normal conditions in these facilities. This paper examines these operator-initiated events and their consequences. The analysis of loop-operator-initiated events indicates there is no damage to the reactor core even when assuming no operator intervention for mitigation. However, analysis does assume a scram occurs when required by the reactor protection systems.

  7. The high-risk plaque initiative: primary prevention of atherothrombotic events in the asymptomatic population.

    PubMed

    Falk, Erling; Sillesen, Henrik; Muntendam, Pieter; Fuster, Valentin

    2011-10-01

    The High-Risk Plaque (HRP) Initiative is a research and development effort to advance the understanding, recognition, and management of asymptomatic individuals at risk for a near-term atherothrombotic event such as myocardial infarction or stroke. Clinical studies using the newest technologies have been initiated, including the BioImage Study in which novel approaches are tested in a typical health plan population. Asymptomatic at-risk individuals were enrolled, including a survey-only group (n = 865), a group undergoing traditional risk factor scoring (n = 718), and a group in which all were assessed for both risk factors and subclinical atherosclerosis (n = 6104). The latter two groups underwent baseline examination in a dedicated mobile facility equipped with advanced imaging tools suitable for noninvasive screening for subclinical atherosclerosis (coronary artery calcium by computed tomography [CT], carotid and aortic disease by ultrasound, and ankle-brachial index). Selected participants were offered advanced imaging (contrast-enhanced CT, magnetic resonance imaging, and positron emission tomography/CT). Plasma, PAXgene RNA, and DNA samples were obtained for biomarker discovery studies. All individuals will be followed until 600 major atherothrombotic events have occurred in those undergoing imaging.

  8. Evaluating MJO Event Initiation and Decay in the Skeleton Model using an RMM-like Index

    NASA Astrophysics Data System (ADS)

    Stachnik, J. P.; Waliser, D. E.; Majda, A.; Stechmann, S. N.; Thual, S.

    2015-12-01

    The Madden-Julian oscillation (MJO) skeleton model is a low-order dynamic model that is capable of simulating many of the observed features of the MJO. This study develops a model- based "MJO" index that is similar to the well-known real-time multivariate MJO (RMM) index to better facilitate comparison between the skeleton model and observational data. Multivariate and univariate empirical orthogonal function (EOF) analyses were performed on the convective heating and zonal wind data taken from the skeleton model for simulations forced with an idealized warm pool and observed sea surface temperatures (SSTs). The leading EOF modes indicated a wavenumber-1 convectively-coupled circulation anomaly with zonal asymmetries that closely resembled the observed RMM EOFs, especially when the model was forced with observed SSTs. The RMM-like index was used to compute an MJO climatology and document the occurrence of primary, continuing, and terminating MJO events in the skeleton model. The overall amount of MJO activity and event lengths compared reasonably well to observations for such a simple model. Attempts at reconciling the observed geographic distribution of MJO events were not successful for the stochastic simulations, though the introduction of stochasticity to the convective parameterization was necessary in order to produce composite MJOs that initiate and decay with time scales similar to observations. Finally, analysis indicates that the existence of higher-frequency, eastward travelling waves with larger wavenumbers (k ≈ 12) embedded within the large-scale flow often precedes MJO termination in the skeleton model.

  9. Initiation of a major calving event captured by high-resolution UAV photogrammetry

    NASA Astrophysics Data System (ADS)

    Jouvet, Guillaume; Abe, Takahiro; Funk, Martin; Seguinot, Julien; Sugiyama, Shin; Weidmann, Yvo

    2016-04-01

    During the summer 2015 field campaign on Bowdoin glacier (Northwest Greenland), the camera inboard a UAV captured the initiation of a major calving event with 7 centimetre accuracy. Two UAV flights were operated prior to and during the opening of a large crack that formed about 100 metre upstream from the calving front, propagated laterally over more than a kilometre and eventually lead to calving. The post-processing of the resulting aerial images by structure-from-motion and feature-tracking techniques allowed us to infer surface velocity fields before and during crack opening. Detailed analysis of maximum principal stresses computed from both velocity fields indicate that the event was triggered by high vertical shear stresses between a lateral band of slow flow where the glacier is solidly anchored to shallow bedrock, and a central band of fast flow where the glacier is nearly floating due to deeper bedrock. We estimate that the observed event contributed by 5 to 10% to the annual mass loss by calving.

  10. Event Detection and Location of Earthquakes Using the Cascadia Initiative Dataset

    NASA Astrophysics Data System (ADS)

    Morton, E.; Bilek, S. L.; Rowe, C. A.

    2015-12-01

    The Cascadia subduction zone (CSZ) produces a range of slip behavior along the plate boundary megathrust, from great earthquakes to episodic slow slip and tremor (ETS). Unlike other subduction zones that produce great earthquakes and ETS, the CSZ is notable for the lack of small and moderate magnitude earthquakes recorded. The seismogenic zone extent is currently estimated to be primarily offshore, thus the lack of observed small, interplate earthquakes may be partially due to the use of only land seismometers. The Cascadia Initiative (CI) community seismic experiment seeks to address this issue by including ocean bottom seismometers (OBS) deployed directly over the locked seismogenic zone, in addition to land seismometers. We use these seismic data to explore whether small magnitude earthquakes are occurring on the plate interface, but have gone undetected by the land-based seismic networks. We select a subset of small magnitude (M0.1-3.7) earthquakes from existing earthquake catalogs, based on land seismic data, whose preliminary hypocentral locations suggest they may have occurred on the plate interface. We window the waveforms on CI OBS and land seismometers around the phase arrival times for these earthquakes to generate templates for subspace detection, which allows for additional flexibility over traditional matched filter detection methods. Here we present event detections from the first year of CI deployment and preliminary locations for the detected events. Initial results of scanning the first year of the CI deployment using one cluster of template events, located near a previously identified subducted seamount, include 473 detections on OBS station M08A (~61.6 km offshore) and 710 detections on OBS station J25A (~44.8 km northeast of M08A). Ongoing efforts include detection using additional OBS stations along the margin, as well as determining locations of clusters detected in the first year of deployment.

  11. A Method to Quantify Plant Availability and Initiating Event Frequency Using a Large Event Tree, Small Fault Tree Model

    SciTech Connect

    Kee, Ernest J.; Sun, Alice; Rodgers, Shawn; Popova, ElmiraV; Nelson, Paul; Moiseytseva, Vera; Wang, Eric

    2006-07-01

    South Texas Project uses a large fault tree to produce scenarios (minimal cut sets) used in quantification of plant availability and event frequency predictions. On the other hand, the South Texas Project probabilistic risk assessment model uses a large event tree, small fault tree for quantifying core damage and radioactive release frequency predictions. The South Texas Project is converting its availability and event frequency model to use a large event tree, small fault in an effort to streamline application support and to provide additional detail in results. The availability and event frequency model as well as the applications it supports (maintenance and operational risk management, system engineering health assessment, preventive maintenance optimization, and RIAM) are briefly described. A methodology to perform availability modeling in a large event tree, small fault tree framework is described in detail. How the methodology can be used to support South Texas Project maintenance and operations risk management is described in detail. Differences with other fault tree methods and other recently proposed methods are discussed in detail. While the methods described are novel to the South Texas Project Risk Management program and to large event tree, small fault tree models, concepts in the area of application support and availability modeling have wider applicability to the industry. (authors)

  12. When the Sky Falls: Performing Initial Assessments of Bright Atmospheric Events

    NASA Technical Reports Server (NTRS)

    Cooke, William J.; Brown, Peter; Blaauw, Rhiannon; Kingery, Aaron; Moser, Danielle

    2015-01-01

    The 2013 Chelyabinsk super bolide was the first "significant" impact event to occur in the age of social media and 24 hour news. Scientists, used to taking many days or weeks to analyze fireball events, were hard pressed to meet the immediate demands (within hours) for answers from the media, general public, and government officials. Fulfilling these requests forced many researchers to exploit information available from various Internet sources - videos were downloaded from sites like Youtube, geolocated via Google Street View, and quickly analyzed with improvised software; Twitter and Facebook were scoured for eyewitness accounts of the fireball and reports of meteorites. These data, combined with infrasound analyses, enabled a fairly accurate description of the Chelyabinsk event to be formed within a few hours; in particular, any relationship to 2012 DA14 (which passed near Earth later that same day) was eliminated. Results of these analyses were quickly disseminated to members of the NEO community for press conferences and media interviews. Despite a few minor glitches, the rapid initial assessment of Chelyabinsk was a triumph, permitting the timely conveyance of accurate information to the public and the incorporation of social media into fireball analyses. Beginning in 2008, the NASA Meteoroid Environments Office, working in cooperation with Western's Meteor Physics Group, developed processes and software that permit quick characterization - mass, trajectory, and orbital properties - of fireball events. These tools include automated monitoring of Twitter to establish the time of events (the first tweet is usually no more than a few seconds after the fireball), mining of Youtube and all sky camera web archives to locate videos suitable for analyses, use of Google Earth and Street View to geolocate the video locations, and software to determine the fireball trajectory and object orbital parameters, including generation of animations suitable for popular media

  13. Exploring the Synoptic Differences Between MJO Initiation Events Identified by Multiple Algorithms

    NASA Astrophysics Data System (ADS)

    Vargas Martes, R. M.; Hartten, L. M.

    2015-12-01

    The Madden-Julian Oscillation (MJO) is a tropical phenomenon that develops over the Indian Ocean. This intraseasonal oscillation consists of an extensive area of convection, about 1000 km across, that releases latent heat in the mid-troposphere, and this heating forces planetary-scale waves to travel through the upper troposphere. These waves can affect weather and climate in the extratropical regions. Since our computational models do not simulate the MJO correctly, international efforts are underway to improve our understanding of the processes involved, especially during the MJO's early stages. This study examines and compares MJO initiation events and types (primary, intensifying, non-MJO) identified by researchers using four methods during 1998-2009 boreal winters. Two methods focused on the precipitation aspect of the oscillation, and the others focused on circulation. Five variables were selected for analysis: temperature at 400 hPa, outgoing long-wave radiation (OLR), sea level pressure (SLP), and zonal winds at 200 and 850 hPa. Twelve MJO events were selected, and four were analyzed. The five variables' contributions to each event were mapped using the MJO-like mode recently identified by other scientists from unfiltered five-day mean gridded data. These visualizations show consistent behaviors in OLR, temperature, and SLP. Positive OLR anomalies occurred in the Indian Ocean before MJO convection began, supporting another research group's idea of an MJO "dry dynamic mode." The MJO-like mode also depicts some previously observed behavior in MJO precursor variables. The results also serve to validate the MJO-like mode and demonstrate that it identifies both MJO and non-MJO convection.

  14. Fragile X founder chromosomes in Italy: A few initial events and possible explanation for their heterogeneity

    SciTech Connect

    Chiurazzi, P.; Genuardi, M.; Kozak, L.; Neri, G.

    1996-07-12

    A total of 137 fragile X and 235 control chromosomes from various regions of Italy were haplotyped by analyzing two neighbouring marker microsatellites, FRAXAC1 and DXS548. The number of CGG repeats at the 5{prime} end of the FMR1 gene was also assessed in 141 control chromosomes and correlated with their haplotypes. Significant linkage disequilibrium between some {open_quotes}major{close_quotes} haplotypes and fragile X was observed, while other {open_quotes}minor{close_quotes} haplotypes may have originated by subsequent mutation at the marker microsatellite loci and/or recombination between them. Recent evidence suggests that the initial mechanism leading to CGG instability might consist of rare (10{sup -6/-7}) CGG repeat slippage events and/or loss of a stabilizing AGG via A-to-C transversion. Also, the apparently high variety of fragile X chromosomes may be partly due to the relatively high mutation rate (10{sup -4/-5}) of the microsatellite markers used in haplotyping. Our fragile X sample also showed a higher than expected heterozygosity when compared to the control sample and we suggest that this might be explained by the chance occurrence of the few founding events on different chromosomes, irrespective of their actual frequency in the population. Alternatively, a local mechanism could enhance the microsatellite mutation rate only on fragile X chromosomes, or fragile X mutations might occur more frequently on certain background haplotypes. 59 refs., 4 figs.

  15. Validity of Taylor's Dissipation-Viscosity Independence Postulate in Variable-Viscosity Turbulent Fluid Mixtures

    NASA Astrophysics Data System (ADS)

    Lee, Kurnchul; Girimaji, Sharath S.; Kerimo, Johannes

    2008-08-01

    G. I. Taylor’s postulate [Proc. R. Soc. APRLAAZ0080-4630 151, 421 (1935)10.1098/rspa.1935.0158] that dissipation is independent of viscosity at high Reynolds numbers is the foundation of many single-fluid turbulence theories and closure models. The validity of this key postulate in an important class of flows, turbulent mixtures, is not yet clearly established. We devise a simple numerical experiment of decaying turbulence in a mixture of two fluids of vastly different viscosities to examine dissipation scaling. Initially, the two fluids are segregated, and dissipation is directly proportional to viscosity. As turbulence evolves and fluids mix, the velocity gradients rapidly adapt to the viscosity field, and within one-half eddy turnover time, dissipation-viscosity independence is established. Viscosity-weighted velocity-gradient skewness is shown to be constant, leading to the validity of Taylor’s postulate in turbulent mixtures.

  16. Holland's Theory of Vocational Choice and Postulated Value Dimensions.

    ERIC Educational Resources Information Center

    Laudeman, Kent A.; Griffeth, Paul

    1978-01-01

    The validity of Holland's vocational personality types and their relationship to value dimensions were examined in light of Holland's theory of vocational choice. The results generally supported Holland's postulated personality typologies and value dimensions. (Author/JKS)

  17. Myosin di-phosphorylation and peripheral actin bundle formation as initial events during endothelial barrier disruption.

    PubMed

    Hirano, Mayumi; Hirano, Katsuya

    2016-02-11

    The phosphorylation of the 20-kD myosin light chain (MLC) and actin filament formation play a key role in endothelial barrier disruption. MLC is either mono- or di-phosphorylated (pMLC and ppMLC) at T18 or S19. The present study investigated whether there are any distinct roles of pMLC and ppMLC in barrier disruption induced by thrombin. Thrombin induced a modest bi-phasic increase in pMLC and a robust mono-phasic increase in ppMLC. pMLC localized in the perinuclear cytoplasm during the initial phase, while ppMLC localized in the cell periphery, where actin bundles were formed. Later, the actin bundles were rearranged into stress fibers, where pMLC co-localized. Rho-kinase inhibitors inhibited thrombin-induced barrier disruption and peripheral localization of ppMLC and actin bundles. The double, but not single, mutation of phosphorylation sites abolished the formation of peripheral actin bundles and the barrier disruption, indicating that mono-phosphorylation of MLC at either T18 or S19 is functionally sufficient for barrier disruption. Namely, the peripheral localization, but not the degree of phosphorylation, is suggested to be essential for the functional effect of ppMLC. These results suggest that MLC phosphorylation and actin bundle formation in cell periphery are initial events during barrier disruption.

  18. Koch's postulates, microbial dysbiosis and inflammatory bowel disease.

    PubMed

    Singh, V P; Proctor, S D; Willing, B P

    2016-07-01

    Over the past 20 years, a growing amount of evidence supports the role of microbes and an imbalanced microbiota in inflammatory bowel disease (IBD). While many reviews have been written on the microbiota in IBD, few have considered how they fulfil the Koch's postulates. In this review, we consider how the Koch's postulates might be modified so that they can be fulfilled for polymicrobial diseases, and we discuss the progress made to date in fulfilling them.

  19. Pernicious Residues of Foundational Postulates: Their Impact on Women.

    PubMed

    Abrams, Samuel

    2015-01-01

    It has long been recognized that many of the original psychoanalytic views of women were derived from misguided theories. Regrettably, residues of the foundational postulates that informed those theories still persist, assuring a pervasive gender bias even in contemporary psychoanalytic investigations. This contribution describes where those postulates reside, while proposing alternates that could prove far more useful for the theory and practice of our profession.

  20. SILER: Seismic-Initiated events risk mitigation in Lead-cooled Reactors

    SciTech Connect

    Forni, M.; De Grandis, S.

    2012-07-01

    SILER is a Collaborative Project, partially funded by the European Commission, aimed at studying the risk associated to seismic initiated events in Generation IV Heavy Liquid Metal reactors and developing adequate protection measures. The attention is focused on the evaluation of the effects of earthquakes (with particular regards to beyond design seismic events) and to the identification of mitigation strategies, acting both on structures and components design (as well as on the development of seismic isolation devices) which can also have positive effects on economics, leading to an high level of plant design standardization. Attention is also devoted to the identification of plant layout solutions able to avoid risks of radioactive release from both the core and other structures (i.e. the spent fuel storage pools). Specific effort is paid to the development of guidelines and design recommendations for addressing the seismic issue in next generation reactor systems. In addition, consideration will be devoted to transfer the knowledge developed in the project to Generation III advanced systems, in line with the objective of the SNE-TP SRA to support present and future Light Water Reactors and their further development, for which safety issues are key aspects to be addressed. Note, in this respect, that the benefits of base isolation in terms of response to design seismic actions are already widely recognized for Generation III LWRs, along with the possibility of a significant standardization of structural and equipment design. SILER activities started on October 1 st 2011 and are carried out by 18 partners: ENEA (Italy, Coordinator), AREVA NP SAS (France), SCK-CEN (Belgium), FIP Industriale (Italy), MAURER SOHENE (Germany), EC-JRC (Ispra (Italy)), SINTEC (Italy), KTH (Sweden), BOA-BKT (Germany), IDOM (Spain), ANSALDO (Italy), IPUL (Latvia), NUMERIA (Italy), VCE (Austria), SRS (Italy), CEA (France), EA (Spain), NUVIA (France). (authors)

  1. Economic Analysis of a Postulated space Tourism Transportation System

    NASA Astrophysics Data System (ADS)

    Hill, Allan S.

    2002-01-01

    Design concepts and associated costs were defined for a family of launch vehicles supporting a space tourism endeavor requiring the weekly transport of space tourists to and from an Earth- orbiting facility. The stated business goal for the Space Tourist Transportation System (STTS) element of the proposed commercial space venture was to transport and return ~50 passengers a week to LEO at a cost of roughly 50 K per seat commencing in 2005. This paper summarizes the economic analyses conducted within a broader Systems Engineering study of the postulated concept. Parametric costs were derived using TransCostSystems' (TCS) Cost Engineering Handbook, version 7. Costs were developed as a function of critical system characteristics and selected business scenarios. Various economic strategies directed toward achieving a cost of ~50 K per seat were identified and examined. The study indicated that with a `nominal' business scenario, the initial cost for developing and producing a fully reusable, 2-stage STTS element for a baseline of 46-passengers was about 15.5 B assuming a plausible `commercialization factor' of 0.333. The associated per-seat ticket cost was ~890 K, more than an order of magnitude higher than desired. If the system is enlarged to 104 passengers for better efficiency, the STTS initial cost for the nominal business scenario is increased to about 19.8 B and the per-seat ticket cost is reduced to ~530 K. It was concluded that achieving the desired ticket cost of 50 K per seat is not feasible unless the size of the STTS, and therefore of the entire system, is substantially increased. However, for the specified operational characteristics, it was shown that a system capacity of thousands of passengers per week is required. This implies an extremely high total system development cost, which is not very realistic as a commercial venture, especially in the proposed time frame. These results suggested that ambitious commercial space ventures may have to rely on

  2. Frequency of cardiac events at four years among initially asymptomatic filipinos with the Brugada type 1 electrocardiographic pattern.

    PubMed

    Domingo, Giselle Gervacio; Jocson, Gabriel; Dans, Antonio

    2011-03-01

    Brugada type 1 electrocardiographic (ECG) pattern occurs in 0.2% of Filipinos. A knowledge gap exists on the natural course of asymptomatic patients with Brugada type 1 ECG pattern. Most studies that reported cohort event rates were taken from hospitals or referral centers. This is the first cohort from an entire country where the subjects were selected randomly. The objective of this study was to describe the frequency of cardiac events at 4 and 6 years of 7 patients with Brugada type 1 ECG pattern of 3,907 patients previously screened from the general population of the Philippines during the National Nutrition and Health Survey. Personal interviews at year 4 using a structured questionnaire were conducted by 1 of the investigators. Occurrences of major (syncope, seizure, unexplained accidents, sudden death) and minor events in subjects and their first- and second-degree relatives were elicited. Six-year follow-up by text messaging was conducted to ascertain vital status and occurrence of cardiac events. All 7 patients with Brugada type 1 ECG pattern were men. Three of the 7 initially asymptomatic subjects (43%, 95 confidence interval 6 to 80) developed a major cardiac event by the fourth year. Those with events were younger than those without events. All 7 were alive by the sixth year. No additional events were noted between the fourth and sixth years. In conclusion, cardiac events are considerable in initially asymptomatic Filipinos with Brugada type 1 ECG pattern.

  3. Initial events during the evolution of C4 photosynthesis in C3 species of Flaveria.

    PubMed

    Sage, Tammy L; Busch, Florian A; Johnson, Daniel C; Friesen, Patrick C; Stinson, Corey R; Stata, Matt; Sultmanis, Stefanie; Rahman, Beshar A; Rawsthorne, Stephen; Sage, Rowan F

    2013-11-01

    The evolution of C4 photosynthesis in many taxa involves the establishment of a two-celled photorespiratory CO2 pump, termed C2 photosynthesis. How C3 species evolved C2 metabolism is critical to understanding the initial phases of C4 plant evolution. To evaluate early events in C4 evolution, we compared leaf anatomy, ultrastructure, and gas-exchange responses of closely related C3 and C2 species of Flaveria, a model genus for C4 evolution. We hypothesized that Flaveria pringlei and Flaveria robusta, two C3 species that are most closely related to the C2 Flaveria species, would show rudimentary characteristics of C2 physiology. Compared with less-related C3 species, bundle sheath (BS) cells of F. pringlei and F. robusta had more mitochondria and chloroplasts, larger mitochondria, and proportionally more of these organelles located along the inner cell periphery. These patterns were similar, although generally less in magnitude, than those observed in the C2 species Flaveria angustifolia and Flaveria sonorensis. In F. pringlei and F. robusta, the CO2 compensation point of photosynthesis was slightly lower than in the less-related C3 species, indicating an increase in photosynthetic efficiency. This could occur because of enhanced refixation of photorespired CO2 by the centripetally positioned organelles in the BS cells. If the phylogenetic positions of F. pringlei and F. robusta reflect ancestral states, these results support a hypothesis that increased numbers of centripetally located organelles initiated a metabolic scavenging of photorespired CO2 within the BS. This could have facilitated the formation of a glycine shuttle between mesophyll and BS cells that characterizes C2 photosynthesis.

  4. Safely Teaching Koch's Postulates on the Causation of Infectious Disease.

    ERIC Educational Resources Information Center

    Stewart, Peter R.

    1990-01-01

    Described is an activity in which the interactions between a parasite and its host may be demonstrated using the relationship between yogurt and two species of bacteria. Background information on Koch's postulates is provided. Materials, laboratory procedures, and results are discussed. (CW)

  5. The necessity of the second postulate in special relativity

    NASA Astrophysics Data System (ADS)

    Drory, Alon

    2015-08-01

    Many authors noted that the principle of relativity together with space-time homogeneity and isotropy restricts the form of the coordinate transformations from one inertial frame to another to being Lorentz-like. The equations contain a free parameter, k (equal to c-2 in special relativity), whose value is claimed to be merely an empirical matter, so that special relativity does not need the postulate of constancy of the speed of light. I analyze this claim and argue that the distinction between the cases k=0 and k ≠ 0 is on the level of a postulate and that until we assume one or the other, we have an incomplete structure that leaves many fundamental questions undecided, including basic prerequisites of experimentation. I examine an analogous case in which isotropy is the postulate dropped and use it to illustrate the problem. Finally I analyze two attempts by Sfarti, and Behera and Mukhopadhyay to derive the constancy of the speed of light from the principle of relativity. I show that these attempts make hidden assumptions that are equivalent to the second postulate.

  6. A Conceptual Derivation of Einstein's Postulates of Special Relativity.

    ERIC Educational Resources Information Center

    Bearden, Thomas E.

    This document presents a discussion and conceptual derivation of Einstein's postulates of special relativity. The perceptron approach appears to be a fundamentally new manner of regarding physical phenomena and it is hoped that physicists will interest themselves in the concept. (Author)

  7. Changing Postulates Can Provide Variety and Meaningful Learning.

    ERIC Educational Resources Information Center

    Mahaffy, Donald

    1982-01-01

    An approach is presented that is based on modifying the standard axiomatic system found in high school geometry books. Such changes start with the introduction of a side-angle-side (SAS) postulate for similar triangles. It is shown how the new system can prove existence and uniqueness of parallel lines. (MP)

  8. Piezoelectric-based event sensing and energy-harvesting power sources for thermal battery initiation in gun-fired munitions

    NASA Astrophysics Data System (ADS)

    Rastegar, J.; Feng, D.; Pereira, C.

    2014-06-01

    A novel class of piezoelectric-based energy harvesting devices with integrated safety and firing setback event detection electronics and logic circuitry that can be used in gun-fired munitions is presented. In this paper, the application of the device to the development of initiators for thermal reserve batteries in gun-fire munitions is presented. The novel and highly efficient electrical energy collection and storage and event detection and safety electronics used allows the use of a very small piezoelectric element. As a result, such devices can be highly miniaturized for used in small reserve batteries. For thermal battery initiation, when the prescribed firing setback acceleration profile, i.e., the prescribed all-fire condition is detected, a highly efficient charge collection electronic circuitry routes the charges generated by the piezoelectric element of the device to the initiator bridge element, thereby causing the thermal battery pyrotechnic material to be ignited. For munitions powered by thermal reserve batteries, the present initiation device provides a self-powered initiator with full no-fire safety circuitry for protection against accidental drops, transportation vibration, and other similar low amplitude accelerations and/or high amplitude but short duration acceleration events. The device is shown to be readily set to initiate thermal batteries under almost any all-fire conditions. The device can be readily hardened to withstand very high G firing setback accelerations in excess of 100,000 G and the harsh firing environment. The design of prototypes and testing under realistic conditions are presented.

  9. Investigating Progression in Substance Use Initiation Using a Discrete-Time Multiple Event Process Survival Mixture (MEPSUM) Approach

    PubMed Central

    Richmond-Rakerd, Leah S.; Fleming, Kimberly A.; Slutske, Wendy S.

    2015-01-01

    The order and timing of substance initiation has significant implications for later problematic patterns of use. Despite the need to study initiation from a multivariate framework, survival analytic methods typically cannot accommodate more than two substances in one model. The Discrete-Time Multiple Event Process Survival Mixture (MEPSUM; Dean, Bauer, & Shanahan, 2014) model represents an advance by incorporating more than two outcomes and enabling establishment of latent classes within a multivariate hazard distribution. Employing a MEPSUM approach, we evaluated patterns of tobacco, alcohol, and cannabis initiation in the National Longitudinal Study of Adolescent to Adult Health (N=18,923). We found four classes that differed in their ages and ordering of peak initiation risk. Demographics, externalizing psychopathology, and personality significantly predicted class membership. Sex differences in the association between delinquency and initiation patterns also emerged. Findings support the utility of the MEPSUM approach in elucidating developmental pathways underlying clinically relevant phenomena. PMID:27127730

  10. A postulate leading to the Titius-Bode law

    NASA Astrophysics Data System (ADS)

    Louise, R.

    1982-02-01

    A formalism similar to Sommerfeld's (1916) is examined, which accounts for the planetary distribution of the solar system. The analysis is based on the early quantum theory, and emphasizes that no connection exists between the Sommerfeld quantum rule and the assumed equation in the present analysis. The assumed equation seems to reflect a nonclassical property of gravitation, and may be a pure coincidence leading to the T-B law, and thus may have no significance other than that of an exotic postulate.

  11. Thermal response of a can handling unit (CHU) to a postulated plutonium hydride burn

    SciTech Connect

    Crea, B.A.

    1998-05-21

    A series of analyses were performed to support the design of the Can Handling Unit (CHU). The subject analyses focused on determining the time to repressurize a subatmospheric storage can containing plutonium metal versus the initial hole size and the transient thermal response to a postulated chemical reaction of 150 grams of plutonium hydride. Limiting the amount of gaseous reactants either by inerting the CHU or using a very small hole size for the initial opening appears to be a viable method of controlling the rate of the exothermic chemical reactions and system temperatures.

  12. Initiation of coronal mass ejection event observed on 2010 November 3: multi-wavelength perspective

    SciTech Connect

    Mulay, Sargam; Subramanian, Srividya; Tripathi, Durgesh; Isobe, Hiroaki; Glesener, Lindsay

    2014-10-10

    One of the major unsolved problems in solar physics is that of coronal mass ejection (CME) initiation. In this paper, we have studied the initiation of a flare-associated CME that occurred on 2010 November 3 using multi-wavelength observations recorded by the Atmospheric Imaging Assembly on board the Solar Dynamics Observatory and the Reuven Ramaty High Energy Solar Spectroscopic Imager. We report an observation of an inflow structure initially in the 304 Å and the 1600 Å images a few seconds later. This inflow structure was detected as one of the legs of the CME. We also observed a non-thermal compact source concurrent and near co-spatial with the brightening and movement of the inflow structure. The appearance of this compact non-thermal source, brightening, and movement of the inflow structure and the subsequent outward movement of the CME structure in the corona led us to conclude that the CME initiation was caused by magnetic reconnection.

  13. Event-Based Surveillance During EXPO Milan 2015: Rationale, Tools, Procedures, and Initial Results

    PubMed Central

    Manso, Martina Del; Caporali, Maria Grazia; Napoli, Christian; Linge, Jens P.; Mantica, Eleonora; Verile, Marco; Piatti, Alessandra; Pompa, Maria Grazia; Vellucci, Loredana; Costanzo, Virgilio; Bastiampillai, Anan Judina; Gabrielli, Eugenia; Gramegna, Maria; Declich, Silvia

    2016-01-01

    More than 21 million participants attended EXPO Milan from May to October 2015, making it one of the largest protracted mass gathering events in Europe. Given the expected national and international population movement and health security issues associated with this event, Italy fully implemented, for the first time, an event-based surveillance (EBS) system focusing on naturally occurring infectious diseases and the monitoring of biological agents with potential for intentional release. The system started its pilot phase in March 2015 and was fully operational between April and November 2015. In order to set the specific objectives of the EBS system, and its complementary role to indicator-based surveillance, we defined a list of priority diseases and conditions. This list was designed on the basis of the probability and possible public health impact of infectious disease transmission, existing statutory surveillance systems in place, and any surveillance enhancements during the mass gathering event. This article reports the methodology used to design the EBS system for EXPO Milan and the results of 8 months of surveillance. PMID:27314656

  14. Development of Simplified Probabilistic Risk Assessment Model for Seismic Initiating Event

    SciTech Connect

    S. Khericha; R. Buell; S. Sancaktar; M. Gonzalez; F. Ferrante

    2012-06-01

    ABSTRACT This paper discusses a simplified method to evaluate seismic risk using a methodology built on dividing the seismic intensity spectrum into multiple discrete bins. The seismic probabilistic risk assessment model uses Nuclear Regulatory Commission’s (NRC’s) full power Standardized Plant Analysis Risk (SPAR) model as the starting point for development. The seismic PRA models are integrated with their respective internal events at-power SPAR model. This is accomplished by combining the modified system fault trees from the full power SPAR model with seismic event tree logic. The peak ground acceleration is divided into five bins. The g-value for each bin is estimated using the geometric mean of lower and upper values of that particular bin and the associated frequency for each bin is estimated by taking the difference between upper and lower values of that bin. The component’s fragilities are calculated for each bin using the plant data, if available, or generic values of median peak ground acceleration and uncertainty values for the components. For human reliability analysis (HRA), the SPAR HRA (SPAR-H) method is used which requires the analysts to complete relatively straight forward worksheets that include the performance shaping factors (PSFs). The results are then used to estimate human error probabilities (HEPs) of interest. This work is expected to improve the NRC’s ability to include seismic hazards in risk assessments for operational events in support of the reactor oversight program (e.g., significance determination process).

  15. W.E. Johnson’s ’Sufficientness’ Postulate.

    DTIC Science & Technology

    1984-11-22

    then serving to distinguish one element of a sample from another. In the situation envisaged by Johnson, Carnap (sea Section 4 below), and others, a...Johnson’s death, Rudolph Carnap and his students vould, unknowingly, reproduce much of Johnson’s work. In 1945 Carnap introduced the function c* [= P{XT.+l...And Just as Johnson grew uneasy with his combination postulate, so too Carnap would later introduce the family of functions fc: 0 < X < am) (-(ni+k)/N

  16. Summit Fuels Push to Improve High Schools: Money, Initiatives Pledged during Two-Day Event

    ERIC Educational Resources Information Center

    Olson, Lynn

    2005-01-01

    The nation's governors adjourned their two-day summit on high schools armed with an expanded arsenal of political and financial commitments to prepare all students for success in college and the workplace. But despite the enthusiastic launch of two major initiatives at the February 26-27, 2005 meeting here, observers cautioned that improving…

  17. Development and Initial Validation of a Life Event Scale for Students.

    ERIC Educational Resources Information Center

    Linden, Wolfgang

    1984-01-01

    Presents a readaptation of the Social Readjustment Rating Scale for college students (N=176). An initial attempt to validate this new scale indicated significantly higher frequencies of medical illness, seeking of psychological help, and academic failures in individuals with above average life change. (Author/JAC)

  18. Radiation and matter: Electrodynamics postulates and Lorenz gauge

    NASA Astrophysics Data System (ADS)

    Bobrov, V. B.; Trigger, S. A.; van Heijst, G. J.; Schram, P. P.

    2016-11-01

    In general terms, we have considered matter as the system of charged particles and quantized electromagnetic field. For consistent description of the thermodynamic properties of matter, especially in an extreme state, the problem of quantization of the longitudinal and scalar potentials should be solved. In this connection, we pay attention that the traditional postulates of electrodynamics, which claim that only electric and magnetic fields are observable, is resolved by denial of the statement about validity of the Maxwell equations for microscopic fields. The Maxwell equations, as the generalization of experimental data, are valid only for averaged values. We show that microscopic electrodynamics may be based on postulation of the d'Alembert equations for four-vector of the electromagnetic field potential. The Lorenz gauge is valid for the averages potentials (and provides the implementation of the Maxwell equations for averages). The suggested concept overcomes difficulties under the electromagnetic field quantization procedure being in accordance with the results of quantum electrodynamics. As a result, longitudinal and scalar photons become real rather than virtual and may be observed in principle. The longitudinal and scalar photons provide not only the Coulomb interaction of charged particles, but also allow the electrical Aharonov-Bohm effect.

  19. Computer simulation of initial events in the biochemical mechanisms of DNA damage

    NASA Technical Reports Server (NTRS)

    Chatterjee, A.; Holley, W. R.

    1993-01-01

    Understanding the systematic and quantitative correlation between the physical events of energy deposition by ionizing radiation and the ensuing chemical and biochemical processes leading to DNA damage is one of the goals in radiation research. Significant progress has been made toward achieving the stated goal by using theoretical modeling techniques. These techniques are strongly dependent on computer simulation procedures. A review of such techniques with details of various stages of simulation development, including a comparison with available experimental data, is presented in this article.

  20. Displaced Water Volume, Potential Energy of Initial Elevation, and Tsunami Intensity: Analysis of Recent Tsunami Events

    NASA Astrophysics Data System (ADS)

    Nosov, Mikhail A.; Bolshakova, Anna V.; Kolesov, Sergey V.

    2014-12-01

    We consider recent ocean-bottom earthquakes for which detailed slip distribution data are available. Using these data and the Okada formulae, we calculate the vector fields of co-seismic bottom deformations, which allow us to determine the displaced water volume and the potential energy of initial elevation of the tsunami source. It is shown that, in the majority of cases, the horizontal components of bottom deformation provide an additional contribution to the displaced water volume and virtually never diminish the contribution of the vertical component. The absolute value of the relative contribution of the horizontal components of bottom deformation to the displaced volume varies from 0.07 to 55 %, on average amounting to 14 %. The displaced volume and the energy of initial elevation (tsunami energy) are examined as functions of the moment magnitude, and the relevant regressions (least-squares fits) are derived. The obtained relationships exhibit good correspondence with the theoretical upper limits that had been obtained under the assumption of uniform slip distribution along a rectangular fault. Tsunami energy calculated on the basis of finite fault model data is compared with the earthquake energy determined from the energy-magnitude relationship by Kanamori. It is shown that tsunami takes from 0.001 to 0.34 % of the earthquake energy, and on average 0.04 %. Finally, we analyze the Soloviev-Imamura tsunami intensity as a function of the following three quantities: (1) the moment magnitude, (2) the decimal logarithm of the absolute value of displaced volume, and (3) the decimal logarithm of the potential energy of initial elevation. The first dependence exhibits rather poor correlation, whereas the second and third dependences demonstrate noticeably higher correlation coefficients. This gives us grounds to suggest considering the displaced volume and the energy of initial elevation as measures of the tsunamigenic potential of an earthquake.

  1. Initial Single Event Effects Testing of the Xilinx Virtex-4 Field Programmable Gate Array

    NASA Technical Reports Server (NTRS)

    Allen, Gregory R.; Swift, Gary M.; Carmichael, C.; Tseng, C.

    2007-01-01

    We present initial results for the thin epitaxial Xilinx Virtex-4 Fie ld Programmable Gate Array (FPGA), and compare to previous results ob tained for the Virtex-II and Virtex-II Pro. The data presented was a cquired through a consortium based effort with the common goal of pr oviding the space community with data and mitigation methods for the use of Xilinx FPGAs in space.

  2. Impact of methionine oxidation as an initial event on the pathway of human prion protein conversion

    PubMed Central

    Elmallah, Mohammed IY; Borgmeyer, Uwe; Betzel, Christian; Redecke, Lars

    2013-01-01

    Prion diseases comprise a group of fatal neurodegenerative disorders characterized by the autocatalytic conversion of the cellular prion protein PrPC into the infectious misfolded isoform PrPSc. Increasing evidence supports a specific role of oxidative stress in the onset of pathogenesis. Although the associated molecular mechanisms remain to be elucidated in detail, several studies currently suggest that methionine oxidation already detected in misfolded PrPSc destabilizes the native PrP fold as an early event in the conversion pathway. To obtain more insights about the specific impact of surface-exposed methionine residues on the oxidative-induced conversion of human PrP we designed, produced, and comparatively investigated two new pseudosulfoxidation mutants of human PrP 121–231 that comprises the well-folded C-terminal domain. Applying circular dichroism spectroscopy and dynamic light scattering techniques we showed that pseudosulfoxidation of all surface exposed Met residues formed a monomeric molten globule-like species with striking similarities to misfolding intermediates recently reported by other groups. However, individual pseudosulfoxidation at the polymorphic M129 site did not significantly contribute to the structural destabilization. Further metal-induced oxidation of the partly unfolded pseudosulfoxidation mutant resulted in the formation of an oligomeric state that shares a comparable size and stability with PrP oligomers detected after the application of different other triggers for structural conversion, indicating a generic misfolding pathway of PrP. The obtained results highlight the specific importance of methionine oxidation at surface exposed residues for PrP misfolding, strongly supporting the hypothesis that increased oxidative stress could be one causative event for sporadic prion diseases and other neurodegenerative disorders. PMID:24121542

  3. Impact of methionine oxidation as an initial event on the pathway of human prion protein conversion.

    PubMed

    Elmallah, Mohammed I Y; Borgmeyer, Uwe; Betzel, Christian; Redecke, Lars

    2013-01-01

    Prion diseases comprise a group of fatal neurodegenerative disorders characterized by the autocatalytic conversion of the cellular prion protein PrP(C) into the infectious misfolded isoform PrP(Sc). Increasing evidence supports a specific role of oxidative stress in the onset of pathogenesis. Although the associated molecular mechanisms remain to be elucidated in detail, several studies currently suggest that methionine oxidation already detected in misfolded PrP(Sc) destabilizes the native PrP fold as an early event in the conversion pathway. To obtain more insights about the specific impact of surface-exposed methionine residues on the oxidative-induced conversion of human PrP we designed, produced, and comparatively investigated two new pseudosulfoxidation mutants of human PrP 121-231 that comprises the well-folded C-terminal domain. Applying circular dichroism spectroscopy and dynamic light scattering techniques we showed that pseudosulfoxidation of all surface exposed Met residues formed a monomeric molten globule-like species with striking similarities to misfolding intermediates recently reported by other groups. However, individual pseudosulfoxidation at the polymorphic M129 site did not significantly contribute to the structural destabilization. Further metal-induced oxidation of the partly unfolded pseudosulfoxidation mutant resulted in the formation of an oligomeric state that shares a comparable size and stability with PrP oligomers detected after the application of different other triggers for structural conversion, indicating a generic misfolding pathway of PrP. The obtained results highlight the specific importance of methionine oxidation at surface exposed residues for PrP misfolding, strongly supporting the hypothesis that increased oxidative stress could be one causative event for sporadic prion diseases and other neurodegenerative disorders.

  4. Effect of initial conditions and of intra-event rainfall intensity variability on shallow landslide triggering return period

    NASA Astrophysics Data System (ADS)

    Peres, David Johnny; Cancelliere, Antonino

    2016-04-01

    Assessment of shallow landslide hazard is important for appropriate planning of mitigation measures. Generally, return period of slope instability is assumed as a quantitative metric to map landslide triggering hazard on a catchment. The most commonly applied approach to estimate such return period consists in coupling a physically-based landslide triggering model (hydrological and slope stability) with rainfall intensity-duration-frequency (IDF) curves. Among the drawbacks of such an approach, the following assumptions may be mentioned: (1) prefixed initial conditions, with no regard to their probability of occurrence, and (2) constant intensity-hyetographs. In our work we propose the use of a Monte Carlo simulation approach in order to investigate the effects of the two above mentioned assumptions. The approach is based on coupling a physically based hydrological and slope stability model with a stochastic rainfall time series generator. By this methodology a long series of synthetic rainfall data can be generated and given as input to a landslide triggering physically based model, in order to compute the return period of landslide triggering as the mean inter-arrival time of a factor of safety less than one. In particular, we couple the Neyman-Scott rectangular pulses model for hourly rainfall generation and the TRIGRS v.2 unsaturated model for the computation of transient response to individual rainfall events. Initial conditions are computed by a water table recession model that links initial conditions at a given event to the final response at the preceding event, thus taking into account variable inter-arrival time between storms. One-thousand years of synthetic hourly rainfall are generated to estimate return periods up to 100 years. Applications are first carried out to map landslide triggering hazard in the Loco catchment, located in highly landslide-prone area of the Peloritani Mountains, Sicily, Italy. Then a set of additional simulations are performed

  5. Initiation, maintenance, and properties of convection in an extreme rainfall event during SCMREX: Observational analysis

    NASA Astrophysics Data System (ADS)

    Wang, Hui; Luo, Yali; Jou, Ben Jong-Dao

    2014-12-01

    A long-lived mesoscale convective system (MCS) with extreme rainfall over the western coastal region of Guangdong on 10 May 2013 during the Southern China Monsoon Rainfall Experiment (SCMREX) is studied. The environmental conditions are characterized by little convective inhibition, low-lifting condensation level, moderate convective available potential energy and precipitable water, and lack of low-level jets from the tropical ocean. Repeated convective back building and subsequent northeastward "echo training" of convective cells are found during the MCS's development stages. However, the initiation/maintenance factors and organization of convection differ significantly during the earlier and later stages. From midnight to early morning, convection is continuously initiated as southeasterly flows near the surface impinge on the east side of mesoscale mountains near the coastal lines and then moves northeastward, leading to formation of two quasi-stationary rainbands. From early morning to early afternoon, new convection is repeatedly triggered along a mesoscale boundary between precipitation-induced cold outflows and warm air from South China Sea and Gulf of Tokin, resulting in the formation of "band training" of several parallel rainbands that move eastward in a later time, i.e., two scales of "training" of convective elements are found. As the MCS dissipates, a stronger squall line moves into the region from the west and passes over within about 3.5 h, contributing about 10%-15% to the total rainfall amount. It is concluded that terrain, near-surface winds, warm advection from the upstream ocean in the boundary layer, and precipitation-generated cold outflows play important roles in initiating and maintaining the extreme rain-producing MCS.

  6. The initiation of blood flow and flow induced events in early vascular development.

    PubMed

    Jones, Elizabeth A V

    2011-12-01

    Within a day of gastrulation, the embryonic heart begins to beat and creates blood flow in the developing cardiovascular system. The onset of blood flow completely changes the environment in which the cardiovascular system is forming. Flow provides physiological feedback such that the developing network adapts to cue provided by the flow. Targeted inactivation of genes that alter early blood fluid dynamics induce secondary defects in the heart and vasculature and therefore proper blood flow is known to be essential for vascular development. Though hemodynamics, or blood fluid dynamics, are known to activate signaling pathways in the mature cardiovascular system in pathologies ranging from artherosclerosis to angiogenesis, the role in development has not been as intensively studied. The question arises how blood vessels in the embryos, which initially lack cells types such as smooth muscle cells, differ in their response to mechanical signals from blood flow as compared to the more mature cardiovascular system. Many genes known to be regulated by hemodynamics in the adult are important for developmental angiogenesis. Therefore the onset of blood flow is of primary importance to vascular development. This review will focus on how blood flow initiates and the effects of the mechanical signals created by blood flow on cardiovascular development.

  7. A random spatial network model based on elementary postulates

    USGS Publications Warehouse

    Karlinger, M.R.; Troutman, B.M.

    1989-01-01

    In contrast to the random topology model, this model ascribes a unique spatial specification to generated drainage networks, a distinguishing property of some network growth models. The simplicity of the postulates creates an opportunity for potential analytic investigations of the probabilistic structure of the drainage networks, while the spatial specification enables analyses of spatially dependent network properties. In the random topology model all drainage networks, conditioned on magnitude (number of first-order streams), are equally likely, whereas in this model all spanning trees of a grid, conditioned on area and drainage density, are equally likely. As a result, link lengths in the generated networks are not independent, as usually assumed in the random topology model. -from Authors

  8. Modeling of aircraft unsteady aerodynamic characteristics. Part 1: Postulated models

    NASA Technical Reports Server (NTRS)

    Klein, Vladislav; Noderer, Keith D.

    1994-01-01

    A short theoretical study of aircraft aerodynamic model equations with unsteady effects is presented. The aerodynamic forces and moments are expressed in terms of indicial functions or internal state variables. The first representation leads to aircraft integro-differential equations of motion; the second preserves the state-space form of the model equations. The formulations of unsteady aerodynamics is applied in two examples. The first example deals with a one-degree-of-freedom harmonic motion about one of the aircraft body axes. In the second example, the equations for longitudinal short-period motion are developed. In these examples, only linear aerodynamic terms are considered. The indicial functions are postulated as simple exponentials and the internal state variables are governed by linear, time-invariant, first-order differential equations. It is shown that both approaches to the modeling of unsteady aerodynamics lead to identical models.

  9. Causation and Disease: The Henle-Koch Postulates Revisited 1

    PubMed Central

    Evans, Alfred S.

    1976-01-01

    The Henle-Koch postulates are reviewed in terms of their full validity in Koch's day and in light of subsequent developments. The changing guidelines developed for viral diseases, for viruses in relation to cancer and to chronic central nervous system infection, and for causative agents in chronic diseases are discussed chronologically. A set of guidelines for both acute infectious and chronic diseases is presented. The need for recognizing the role of the host and the spectrum of host responses, for sound biologic sense in evaluating causal roles of agents in disease, and for flexibility in adapting our guidelines to new knowledge are emphasized. ImagesFIG. 1FIG. 2FIG. 3FIG. 4FIG. 5FIG. 6FIG. 7FIG. 8 PMID:782050

  10. Alpha/sub 1/ receptor coupling events initiated by methoxy-substituted tolazoline partial agonists

    SciTech Connect

    Wick, P.; Keung, A.; Deth, R.

    1986-03-01

    A series of mono- and dimethyoxy substituted tolazoline derivatives, known to be partial agonists at the alpha/sub 1/ receptor, were compared with the ..cap alpha../sub 1/ selective full agonist phenylephrine (PE) on isolated strips of rabbit aorta Agonist activity was evaluated in contraction, /sup 45/Ca influx, /sup 45/Ca efflux, and /sup 32/P-Phospholipid labelling studies. Maximum contractile responses for the 2-, 3-, and 3, 5- methoxy substituted tolazoline derivatives (10/sup -5/M) were 53.8, 67.6 and 99.7% of the PE (10/sup -5/M) response respectively. These same partial agonists caused a stimulation of /sup 45/Ca influx to the extent of 64, 86, and 95% of the PE response respectively. In /sup 45/Ca efflux studies, (a measure of the intracellular Ca/sup +2/ release) the tolazolines caused: 30%, 63%, and 78% of the PE stimulated level. /sup 32/P-Phosphatidic acid (PA) labelling was measured as an index of PI turnover after ..cap alpha../sub 1/ receptor stimulation. Compared to PE, the 2-, 3-, and 3,5- methoxy substituted tolazoline derivatives caused 22, 46, and 72% PA labelling. The above values are all in reasonable accord with the rank order or agonist activity shown in maximum contractile responses. The results of this investigation suggest that partial agonists stimulate ..cap alpha.. receptor coupling events at a level which is quantitatively comparable to their potencies in causing contraction of arterial smooth muscle.

  11. Coupled prediction of flood response and debris flow initiation during warm and cold season events in the Southern Appalachians, USA

    NASA Astrophysics Data System (ADS)

    Tao, J.; Barros, A. P.

    2013-07-01

    Debris flows associated with rainstorms are a frequent and devastating hazard in the Southern Appalachians in the United States. Whereas warm season events are clearly associated with heavy rainfall intensity, the same cannot be said for the cold season events. Instead, there is a relationship between large (cumulative) rainfall events independently of season, and thus hydrometeorological regime, and debris flows. This suggests that the dynamics of subsurface hydrologic processes play an important role as a trigger mechanism, specifically through soil moisture redistribution by interflow. The first objective of this study is to investigate this hypothesis. The second objective is to assess the physical basis for a regional coupled flood prediction and debris flow warning system. For this purpose, uncalibrated model simulations of well-documented debris flows in headwater catchments of the Southern Appalachians using a 3-D surface-groundwater hydrologic model coupled with slope stability models are examined in detail. Specifically, we focus on two vulnerable headwater catchments that experience frequent debris flows, the Big Creek and the Jonathan Creek in the Upper Pigeon River Basin, North Carolina, and three distinct weather systems: an extremely heavy summertime convective storm in 2011; a persistent winter storm lasting several days; and a severe winter storm in 2009. These events were selected due to the optimal availability of rainfall observations, availability of detailed field surveys of the landslides shortly after they occurred, which can be used to evaluate model predictions, and because they are representative of events that cause major economic losses in the region. The model results substantiate that interflow is a useful prognostic of conditions necessary for the initiation of slope instability, and should therefore be considered explicitly in landslide hazard assessments. Moreover, the relationships between slope stability and interflow are

  12. D-O Events in the Southern Tropics of East Africa? Initial XRF Results From the Lake Malawi Drilling Project

    NASA Astrophysics Data System (ADS)

    Brown, E. T.; Johnson, T. C.; Scholz, C. A.; King, J.; Cohen, A. S.

    2006-12-01

    As part of the Lake Malawi Drilling Project we have undertaken a 1 cm-scale resolution XRF scanning study of core from site 2A in the Northern Basin of the lake (ca. 10 South latitude). This 38-m core provides an essentially continuous record of regional climate over the past 70,000 years, so our XRF analyses correspond to an average temporal resolution of approximately 20 years. We have focused our initial study on certain parameters, including Fe, Zr:Ti, and Si:Ti. These may be interpreted to represent changing input of terrigenous sediments (delivered to the lake rivers), soils developed from weathered volcanic ash (delivered more effectively under drier windier conditions), and biogenic silica, respectively. Our initial analyses of the XRF results indicate abrupt and strong, millennial-scale variability in regional climate throughout the past 70,000 years. The series of events consists of rapid (~100-year) increases in Zr:Ti and Si:Ti followed by slower decreases toward background values. These events are strikingly similar in form and in timing to Dansgaard- Oeschger events of high northern latitudes. The Younger Dryas and the Holocene "cold" periods in the Northern Hemisphere were times of enhanced input of wind-blown volcanic ash-derived materials and of diatom productivity, probably stimulated by northerly winds and upwelling in the north of the lake. Interestingly, in contrast to the Late Glacial and Holocene, times of higher productivity and enhanced input of volcanic-ash derived material in the earlier part of the record coincide with episodes of warming as recorded in Greenland ice. This suggests that a significant change in the tropical response to climate forcing occurred at the time of waning of Northern Hemisphere glaciation.

  13. Accident progression event tree analysis for postulated severe accidents at N Reactor

    SciTech Connect

    Wyss, G.D.; Camp, A.L.; Miller, L.A.; Dingman, S.E.; Kunsman, D.M. ); Medford, G.T. )

    1990-06-01

    A Level II/III probabilistic risk assessment (PRA) has been performed for N Reactor, a Department of Energy (DOE) production reactor located on the Hanford reservation in Washington. The accident progression analysis documented in this report determines how core damage accidents identified in the Level I PRA progress from fuel damage to confinement response and potential releases the environment. The objectives of the study are to generate accident progression data for the Level II/III PRA source term model and to identify changes that could improve plant response under accident conditions. The scope of the analysis is comprehensive, excluding only sabotage and operator errors of commission. State-of-the-art methodology is employed based largely on the methods developed by Sandia for the US Nuclear Regulatory Commission in support of the NUREG-1150 study. The accident progression model allows complex interactions and dependencies between systems to be explicitly considered. Latin Hypecube sampling was used to assess the phenomenological and systemic uncertainties associated with the primary and confinement system responses to the core damage accident. The results of the analysis show that the N Reactor confinement concept provides significant radiological protection for most of the accident progression pathways studied.

  14. 76 FR 43356 - Evaluations of Explosions Postulated To Occur at Nearby Facilities and on Transportation Routes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-20

    ... COMMISSION Evaluations of Explosions Postulated To Occur at Nearby Facilities and on Transportation Routes... for public comment draft regulatory guide (DG), DG-1270, ``Evaluations of Explosions Postulated to... assumptions the NRC's staff finds acceptable for evaluating postulated explosions at nearby facilities...

  15. Bridging EUV and White-Light Observations to Inspect the Initiation Phase of a "Two-Stage" Solar Eruptive Event

    NASA Astrophysics Data System (ADS)

    Byrne, J. P.; Morgan, H.; Seaton, D. B.; Bain, H. M.; Habbal, S. R.

    2014-12-01

    The initiation phase of coronal mass ejections (CMEs) is a very important aspect of solar physics, as these phenomena ultimately drive space weather in the heliosphere. This phase is known to occur between the photosphere and low corona, where many models introduce an instability and/or magnetic reconnection that triggers a CME, often with associated flaring activity. To this end, it is important to obtain a variety of observations of the low corona to build as clear a picture as possible of the dynamics that occur therein. Here, we combine the EUV imagery of the Sun Watcher using Active Pixel System Detector and Image Processing (SWAP) instrument onboard the Project for Onboard Autonomy (PROBA2) with the white-light imagery of the ground-based Mark-IV K-coronameter (Mk4) at Mauna Loa Solar Observatory (MLSO) to bridge the observational gap that exists between the disk imagery of the Atmospheric Imaging Assembly (AIA) onboard the Solar Dynamics Observatory (SDO) and the coronal imagery of the Large Angle Spectrometric Coronagraph (LASCO) onboard the Solar and Heliospheric Observatory (SOHO). Methods of multiscale image analysis were applied to the observations to better reveal the coronal signal while suppressing noise and other features. This allowed an investigation into the initiation phase of a CME that was driven by a rising flux-rope structure from a "two-stage" flaring event underlying an extended helmet streamer. It was found that the initial outward motion of the erupting loop system in the EUV observations coincided with the first X-ray flare peak and led to a plasma pile-up of the white-light CME core material. The characterized CME core then underwent a strong jerk in its motion, as the early acceleration increased abruptly, simultaneously with the second X-ray flare peak. The overall system expanded into the helmet streamer to become the larger CME structure observed in the LASCO coronagraph images, which later became concave-outward in shape

  16. PRESSURE INTEGRITY OF 3013 CONTAINER UNDER POSTULATED ACCIDENT CONDITIONS

    SciTech Connect

    Rawls, G.

    2010-02-01

    A series of tests was carried out to determine the threshold for deflagration-to-detonation transition (DDT), structural loading, and structural response of the Department of Energy 3013 storage systems for the case of an accidental explosion of evolved gas within the storage containers. Three experimental fixtures were used to examine the various issues and three mixtures consisting of either stoichiometric hydrogen-oxygen, stoichiometric hydrogen-oxygen with added nitrogen, or stoichiometric hydrogen-oxygen with an added nitrogen-helium mixture were tested. Tests were carried out as a function of initial pressure from 1 to 3.5 bar and initial temperature from room temperature to 150 C. The elevated temperature tests resulted in a slight increase in the threshold pressure for DDT. The elevated temperature tests were performed to ensure the test results were bounding. Because the change was not significant the elevated temperature data are not presented in the paper. The explosions were initiated with either a small spark or a hot surface. Based on the results of these tests under the conditions investigated, it can be concluded that DDT of a stoichiometric hydrogen-oxygen mixture (and mixtures diluted with nitrogen and helium) within the 3013 containment system does not pose a threat to the structural integrity of the outer container.

  17. A Postulated Mechanism that Leads to Materialization and Dematerialization of Matter and to Antigravity

    DTIC Science & Technology

    1975-10-08

    TITLE fand Subtlll») A POSTULATED MECHANISM THAT LEADS TO MATERIALIZATION AND DEMATERIALIZATION OF MATTER AND TO ANTIGRAVITY S. TYPE OF REPORT...m AD-A020 796 A POSTULATED MECHANISM THAT LEADS TO MATERIALIZATION AND DEMATERIALIZATION OF MATTER AND TO ANTIGRAVITY Thomas E. Bearden Army...Jiife’iPi*^ o CM Öb6140 TECHNICAL REPORT SAM-0 76-1 A POSTULATED MECHANISM THAT LEADS TO MATERIALIZATION AND DEMATERIALIZATION OF MATTER AND TO

  18. Biologically induced initiation of snowball-Earth events, and the circulations of ice and ocean in a globally glaciated scenario

    NASA Astrophysics Data System (ADS)

    McPhaden, M. J.; Finn, C.; McEntee, C.; Krause, F.; Harden, J. W.; Rosenbloom, N. A.; Pendall, E.; Alves Jesus Rydin, C.; Krasa, D.; Shrestha, G.; Cavallaro, N.; Kuperberg, J.; Løvholt, F.; Horspool, N.; Cavanaugh, M. A.; Hankin, E. R.; Davis, J. L.; Evans, J. E.; Gurwick, N. P.; Richardson, R. M.; Landau, E. A.; Uhlenbrock, K. M.; Albert, M. R.; Rack, F. R.; Van Wyk de Vries, B.; Giardino, M.; Wiggins, H. V.; Habib, M. A.; Horan, P.; Stover, D. B.; Kuperberg, J.; Koch, D. M.; Jacob, D. J.; Isern, A. R.; Borg, S. G.; Ryabinin, V.; Hik, D.; Winther, J.; McConnell, W. J.; Baerwald, T. J.; Liu, J.; Winter, J. M.; Ruane, A. C.; Rosenzweig, C.; Jacobs, C. A.; Zanzerkia, E. E.; Cummins, P. R.; Harjadi, P.; Widiyantoro, S.; Natawidjaja, D. H.; Netting, R.; Grunsfeld, J. M.; Freilich, M. H.; Green, J. L.; Giles, B. L.; Stammer, D.; Wefer, G.; Lefebvre, A.; Lucarini, V.; Kanzow, T.; Goddard, L.; McCreary, J. P.; Sprintall, J.; Patterson, M.; Manduca, C. A.; Bralower, T. J.; Egger, A. E.; Klimchuk, J. A.; Nave, L. E.; Harden, J. W.; Horan, P.; Koch, D. M.; Laviolette, R.; Frost, G. J.; Middleton, P.; Uhle, M. E.; Gurney, R. J.; Impey, A.; Carroll, M.; Brown, M. E.; Escobar, V. M.; Murphy, F.; Callaghan, S.; Graber, J. R.; Lawford, R. G.; Koike, T.; Cripe, D.; Gundersen, L. C.; Valette-Silver, N. J.; Bohan, M.; Kaye, J. A.; Freilich, M. H.; Volz, S. M.; Friedl, L.; Komar, G.; Jacobberger-Jellison, P. A.; Luce, P.; Torn, M. S.; Baldocchi, D. D.; Agarwal, D.; Biraud, S. C.; Billesbach, D. P.; Humphrey, M.; Law, B. E.; Papale, D.; Wofsy, S. C.; Quadrelli, R.; Wilson, S.; Liverman, D. M.; Liss, P. S.; Killeen, T.; Watson, R.; Zebiak, S. E.; Tang, Q.; Hong, Y.; Chen, D.; Yang, D.; Rumburg, J.; Newmark, J. S.; Giles, B. L.; DeLuca, E.; Hagan, M. E.; Studinger, M.; Jezek, K. C.; Richter-Menge, J.; Lea, P.; Passalacqua, P.; Oskin, M. E.; Crosby, C.; Glennie, C. L.; Lechner, H. N.; Bowman, L. J.; Barton, T.; Uhle, M. E.; Anderson, G. J.; Fountain, D. M.; Hess, J. W.; Harper, H. E.; Gingerich, P. D.; Groffman, P. M.; Weathers, K. C.; Bernhardt, E. S.; SanClements, M.; Loescher, H. W.; Pitelka, L.; Sandgathe, S. A.; Eleuterio, D. P.; Cortinas, J. V.; McElroy, B. J.; Hsu, L.; Kim, W.; Martin, R. L.; Arrowsmith, R.; Hill, M. C.; Freymueller, J. T.; Marks, D. G.; Sztein, E.; Eichelberger, J. C.; Ismail-Zadeh, A.; Gordeev, E.; Myers, M.; Scholl, D. W.; Ackley, S. F.; Schofield, O.; Costa, D. P.; Marin, J. A.; Pilpipenko, V. A.; Vega, P.; Zesta, E.; Stepanova, M. V.; Uozumi, T.; Nolin, A. W.; Sturm, M.; Tziperman, E.; Abbot, D. S.; Ashkenazy, Y.; Gildor, H.; Halevy, I.; Johnston, D. T.; Knoll, A.; Losch, M. J.; Pollard, D.; Schoof, C.; Schrag, D. P.

    2012-12-01

    , Martin Losch, Hezi Gildor, Dan Schrag). References: Eli Tziperman, I. Halevy, D. T. Johnston, A. H. Knoll, and D. P. Schrag. Biologically induced initiation of Neoproterozoic Snowball-Earth events. Proc. Natl. Acad. Sci. U.S.A., 108(37):15091-15096, doi/10.1073/pnas.1016361108, 2011. Eli Tziperman, Dorian Schuyler Abbot, Yosef Ashkenazy, Hezi Gildor, David Pollard, Christian Schoof, and Daniel P. Schrag. Continental constriction and sea ice thickness in a Snowball-Earth scenario. J. Geophys. Res., 117(C05016):doi:10.1029/2011JC007730, 2012. Yosef Ashkenazy et al, in prep. 2012.

  19. Recommended plutonium release fractions from postulated fires. Final report

    SciTech Connect

    Kogan, V.; Schumacher, P.M.

    1993-12-01

    This report was written at the request of EG&G Rocky Flats, Inc. in support of joint emergency planning for the Rocky Flats Plant (RFP) by EG&G and the State of Colorado. The intent of the report is to provide the State of Colorado with an independent assessment of any respirable plutonium releases that might occur in the event of a severe fire at the plant. Fire releases of plutonium are of interest because they have been used by EG&G to determine the RFP emergency planning zones. These zones are based on the maximum credible accident (MCA) described in the RFP Final Environmental Impact Statement (FEIS) of 1980, that MCA is assumed to be a large airplane crashing into a RFP plutonium building.The objective of this report was first, to perform a worldwide literature review of relevant release experiments from 1960 to the present and to summarize those findings, and second, to provide recommendations for application of the experimental data to fire release analyses at Rocky Flats. The latter step requires translation between experimental and expected RFP accident parameters, or ``scaling.`` The parameters of particular concern are: quantities of material, environmental parameters such as the intensity of a fire, and the physico-chemical forms of the plutonium. The latter include plutonium metal, bulk plutonium oxide powder, combustible and noncombustible wastes contaminated with plutonium oxide powder, and residues from plutonium extraction processes.

  20. Ferrocyanide Safety Program: Analysis of postulated energetic reactions and resultant aerosol generation in Hanford Site Waste Tanks

    SciTech Connect

    Postma, A.K.; Dickinson, D.R.

    1995-09-01

    This report reviews work done to estimate the possible consequences of postulated energetic reactions in ferrocyanide waste stored in underground tanks at the Hanford Site. The issue of explosive reactions was raised in the 1987 Environmental Impact Statement (EIS), where a detonation-like explosion was postulated for the purpose of defining an upper bound on dose consequences for various disposal options. A review of the explosion scenario by the General Accounting Office (GAO) indicated that the aerosol generation and consequent radioactive doses projected for the explosion postulated in the EIS were understated by one to two orders of magnitude. The US DOE has sponsored an extensive study of the hazard posed by uncontrolled exothermic reactions in ferrocyanide waste, and results obtained during the past three years have allowed this hazard to be more realistically assessed. The objective of this report is to summarize the improved knowledge base that now indicates that explosive or vigorous chemical reactions are not credible in the ferrocyanide waste stored in underground tanks. This improved understanding supports the decision not to proceed with further analyses or predictions of the consequences of such an event or with aerosol tests in support of such predictions. 53 refs., 2 tabs.

  1. Initial events during phagocytosis by macrophages viewed from outside and inside the cell: membrane-particle interactions and clathrin

    PubMed Central

    1982-01-01

    The initial events during phagocytosis of latex beads by mouse peritoneal macrophages were visualized by high-resolution electron microscopy of platinum replicas of freeze-dried cells and by conventional thin-section electron microscopy of macrophages postfixed with 1% tannic acid. On the external surface of phagocytosing macrophages, all stages of particle uptake were seen, from early attachment to complete engulfment. Wherever the plasma membrane approached the bead surface, there was a 20-nm-wide gap bridged by narrow strands of material 12.4 nm in diameter. These strands were also seen in thin sections and in replicas of critical-point-dried and freeze-fractured macrophages. When cells were broken open and the plasma membrane was viewed from the inside, many nascent phagosomes had relatively smooth cytoplasmic surfaces with few associated cytoskeletal filaments. However, up to one-half of the phagosomes that were still close to the cell surface after a short phagocytic pulse (2-5 min) had large flat or spherical areas of clathrin basketwork on their membranes, and both smooth and clathrin-coated vesicles were seen fusing with or budding off from them. Clathrin-coated pits and vesicles were also abundant elsewhere on the plasma membranes of phagocytosing and control macrophages, but large flat clathrin patches similar to those on nascent phagosomes were observed only on the attached basal plasma membrane surfaces. These resulted suggest that phagocytosis shares features not only with cell attachment and spreading but also with receptor-mediated pinocytosis. PMID:6813339

  2. Hyperphosphatemic familial tumoral calcinosis: response to acetazolamide and postulated mechanisms.

    PubMed

    Finer, Gal; Price, Heather E; Shore, Richard M; White, Kenneth E; Langman, Craig B

    2014-06-01

    Hyperphosphatemic familial tumoral calcinosis (HFTC) is characterized by enhanced renal phosphate absorption, hyperphosphatemia, and tumor-like extraosseous calcifications due to inactivating mutations in FGF23 or associated proteins. Surgical excision is needed when low phosphate diet and phosphate binders are ineffective. Sporadic reports have supported acetazolamide use. We report on a 7-year-old African American boy who presented with severe HFTC requiring numerous surgical excisions. Tumors continued to appear and others reoccurred despite phosphate restriction and sevelamer carbonate. At the age of 9.5 years, acetazolamide (40 mg/kg/day) was added and resulted in mild metabolic acidosis (bicarbonate 25.3 mEq/L vs. 21.4 mEq/L, P < 0.001; serum pH 7.38 vs. 7.31, P = 0.013, pre- and post-acetazolamide, respectively) but no change in tubular reabsorption of phosphate (TRP) (96.9% vs. 95.9%, P = 0.34) or serum phosphate (6.6 mg/dl vs. 6.9 mg/dl, P = 0.52 pre- and post-acetazolamide, respectively). Following the initiation of acetazolamide therapy, the patient experienced significant improvement in disease course as indicated by resolution of localized bone pain, cessation of tumor formation, and no tumor recurrence. Despite mild metabolic acidosis, our patient had improved linear growth and did not develop any other side effects related to therapy. Intact FGF23 remained abnormally low throughout disease course, while C-terminal FGF23 increased with acetazolamide. We conclude that acetazolamide can control severe HFTC by inducing mild metabolic acidosis despite no change in serum phosphate or TRP. This effect may be exerted though improved calcium-phosphate complex solubility and increased FGF23 locally.

  3. Seismic constraints on a large dyking event and initiation of a transform fault zone in Western Gulf of Aden

    NASA Astrophysics Data System (ADS)

    Ahmed, AbdulHakim; Doubre, Cecile; Leroy, Sylvie; Perrot, Julie; Audin, Laurence; Rolandone, Frederique; Keir, Derek; Al-Ganad, Ismael; Sholan, Jamal; Khanbari, Khaled; Mohamed, Kassim; Vergne, Jerome; Jacques, Eric; Nercessian, Alex

    2013-04-01

    In November 2010, a large number of events were recorded by the world seismic networks showing important activity occurring along the western part of the Aden Ridge. West of the Shulka El Sheik fracture zone, events in this large seismic swarm (magnitudes above 5) occurred in a complex area, where the change of both the ridge direction and the bathymetry suggest the propagation of the ridge into a continental lithosphere and the influence of the Afar plume. We combine several sets of data from permanent networks and temporary 3C broad stations installed after the beginning of the event along the southern and eastern coasts of Yemen and Djibouti respectively, we located more than 600 earthquakes with magnitudes ranging from 2.5 to 5.6 that occurred during the first months following the first event. The spatial distribution of the main seismicity reveals a very clear N115° -trending alignment, parallel to the mean direction of the en-echelon spreading segments that form the ridge at this longitude. Half of the events, which represent half of the total seismic energy released during the first months, are located in the central third section of the segment. Here several volcanic cones and recent lava flows observed from bathymetric and acoustic reflectivity data during the Tadjouraden cruise (Audin, 1999, Dauteuil et al., 2001) constitute the sea floor. In addition to this main activity, two small groups of events suggest the activiation of landslides into a large fan and the activity in a volcanic area 50 km due east from the main active zone. The time evolution of the seismicity shows several bursts of activity. Some of them are clearly related to sudden activities within the volcanic areas, when others exhibit horizontal migration of the events, with velocity around ˜ 1 km/h. The time-space evolution of the seismicity clearly reveals the intrusion of dykes associated with magma propagation from the crustal magmatic centres into the rift zone. Taking into account

  4. Initial Comparison Between a 3D MHD Model and the HAFv2 Kinematic 3D Model: The October/November 2003 Events from the Sun to 6 AU

    SciTech Connect

    Intriligator, Devrie S.; Detman, Thomas; Fry, Craig D.; Sun Wei; Deehr, Charles; Intriligator, James

    2005-08-01

    A first-generation 3D kinematic, space weather forecasting solar wind model (HAFv2) has been used to show the importance of solar generated disturbances in Voyager 1 and Voyager 2 observations in the outer heliosphere. We extend this work by using a 3D MHD model (HHMS) that, like HAFv2, incorporates a global, pre-event, inhomogeneous, background solar wind plasma and interplanetary magnetic field. Initial comparisons are made between the two models of the solar wind out to 6 AU and with in-situ observations at the ACE spacecraft before and after the October/November 2003 solar events.

  5. Comparison of the initial errors most likely to cause a spring predictability barrier for two types of El Niño events

    NASA Astrophysics Data System (ADS)

    Tian, Ben; Duan, Wansuo

    2016-08-01

    In this paper, the spring predictability barrier (SPB) problem for two types of El Niño events is investigated. This is enabled by tracing the evolution of a conditional nonlinear optimal perturbation (CNOP) that acts as the initial error with the biggest negative effect on the El Niño predictions. We show that the CNOP-type errors for central Pacific-El Niño (CP-El Niño) events can be classified into two types: the first are CP-type-1 errors possessing a sea surface temperature anomaly (SSTA) pattern with negative anomalies in the equatorial central western Pacific, positive anomalies in the equatorial eastern Pacific, and accompanied by a thermocline depth anomaly pattern with positive anomalies along the equator. The second are, CP-type-2 errors presenting an SSTA pattern in the central eastern equatorial Pacific, with a dipole structure of negative anomalies in the east and positive anomalies in the west, and a thermocline depth anomaly pattern with a slight deepening along the equator. CP-type-1 errors grow in a manner similar to an eastern Pacific-El Niño (EP-El Niño) event and grow significantly during boreal spring, leading to a significant SPB for the CP-El Niño. CP-type-2 errors initially present as a process similar to a La Niña-like decay, prior to transitioning into a growth phase of an EP-El Niño-like event; but they fail to cause a SPB. For the EP-El Niño events, the CNOP-type errors are also classified into two types: EP-type-1 errors and 2 errors. The former is similar to a CP-type-1 error, while the latter presents with an almost opposite pattern. Both EP-type-1 and 2 errors yield a significant SPB for EP-El Niño events. For both CP- and EP-El Niño, their CNOP-type errors that cause a prominent SPB are concentrated in the central and eastern tropical Pacific. This may indicate that the prediction uncertainties of both types of El Niño events are sensitive to the initial errors in this region. The region may represent a common

  6. The impact of user- and system-initiated personalization on the user experience at large sports events.

    PubMed

    Sun, Xu; May, Andrew; Wang, Qingfeng

    2016-05-01

    This article describes an experimental study investigating the impact on user experience of two approaches of personalization of content provided on a mobile device, for spectators at large sports events. A lab-based experiment showed that a system-driven approach to personalization was generally preferable, but that there were advantages to retaining some user control over the process. Usability implications for a hybrid approach, and design implications are discussed, with general support for countermeasures designed to overcome recognised limitations of adaptive systems.

  7. Preliminary analysis of the postulated changes needed to achieve rail cask handling capabilities at selected light water reactors

    SciTech Connect

    Konzek, G.J.

    1986-02-01

    Reactor-specific railroad and crane information for all LWRs in the US was extracted from current sources of information. Based on this information, reactors were separated into two basic groups consisting of reactors with existing, usable rail cask capabilities and those without these capabilities. The latter group is the main focus of this study. The group of reactors without present rail cask handling capabilities was further separated into two subgroups consisting of reactors considered essentially incapable of handling a large rail cask of about 100 tons and reactors where postulated facility changes could result in rail cask handling capabilities. Based on a selected population of 127 reactors, the results of this assessment indicate that usable rail cask capabilities exist at 83 (65%) of the reactors. Twelve (27%) of the remaining 44 reactors are deemed incapable of handling a large rail cask without major changes, and 32 reactors are considered likely candidates for potentially achieving rail cask handling capabilities. In the latter group, facility changes were postulated that would conceptually enable these reactors to handle large rail casks. The estimated cost per plant of required facility changes varied widely from a high of about $35 million to a low of <$0.3 million. Only 11 of the 32 plants would require crane upgrades. Spur track and right-of-way costs would apparently vary widely among sites. These results are based on preliminary analyses using available generic cost data. They represent lower bound values that are useful for developing an initial assessment of the viability of the postulated changes on a system-wide basis, but are not intended to be absolute values for specific reactors or sites.

  8. Observations and modelling of soil slip-debris flow initiation processes in pyroclastic deposits: the Sarno 1998 event

    NASA Astrophysics Data System (ADS)

    Crosta, G. B.; Dal Negro, P.

    Pyroclastic soils mantling a wide area of the Campanian Apennines are subjected to recurrent instability phenomena. This study analyses the 5 and 6 May 1998 event which affected the Pizzo d'Alvano (Campania, southern Italy). More than 400 slides affecting shallow pyroclastic deposits were triggered by intense and prolonged but not extreme rainfall. Landslides affected the pyroclastic deposits that cover the steep calcareous ridges and are soil slip-debris flows and rapid mudflows. About 30 main channels were deeply scoured by flows which reached the alluvial fans depositing up to 400 000 m3 of material in the piedmont areas. About 75% of the landslides are associated with morphological discontinuities such as limestone cliffs and roads. The sliding surface is located within the pyroclastic cover, generally at the base of a pumice layer. Geotechnical characterisation of pyroclastic deposits has been accomplished by laboratory and in situ tests. Numerical modelling of seepage processes and stability analyses have been run on four simplified models representing different settings observed at the source areas. Seepage modelling showed the formation of pore pressure pulses in pumice layers and the localised increase of pore pressure in correspondence of stratigraphic discontinuities as response to the rainfall event registered between 28 April and 5 May. Numerical modelling provided pore pressure values for stability analyses and pointed out critical conditions where stratigraphic or morphological discontinuities occur. This study excludes the need of a groundwater flow from the underlying bedrock toward the pyroclastic cover for instabilities to occur.

  9. (When and where) Do extreme climate events trigger extreme ecosystem responses? - Development and initial results of a holistic analysis framework

    NASA Astrophysics Data System (ADS)

    Hauber, Eva K.; Donner, Reik V.

    2015-04-01

    In the context of ongoing climate change, extremes are likely to increase in magnitude and frequency. One of the most important consequences of these changes is that the associated ecological risks and impacts are potentially rising as well. In order to better anticipate and understand these impacts, it therefore becomes more and more crucial to understand the general connection between climate extremes and the response and functionality of ecosystems. Among other region of the world, Europe presents an excellent test case for studies concerning the interaction between climate and biosphere, since it lies in the transition region between cold polar and warm tropical air masses and thus covers a great variety of different climatic zones and associated terrestrial ecosystems. The large temperature differences across the continent make this region particularly interesting for investigating the effects of climate change on biosphere-climate interactions. However, previously used methods for defining an extreme event typically disregard the necessity of taking seasonality as well as seasonal variance appropriately into account. Furthermore, most studies have focused on the impacts of individual extreme events instead of considering a whole inventory of extremes with their respective spatio-temporal extents. In order to overcome the aforementioned research gaps, this work introduces a new approach to studying climate-biosphere interactions associated with extreme events, which comprises three consecutive steps: (1) Since Europe exhibits climatic conditions characterized by marked seasonality, a novel method is developed to define extreme events taking into account the seasonality in all quantiles of the probability distribution of the respective variable of interest. This is achieved by considering kernel density estimates individually for each observation date during the year, including the properly weighted information from adjacent dates. By this procedure, we obtain

  10. The medical effects of postulated accidental release of radioactive material from Heysham Nuclear Power Station.

    PubMed

    Oliver, D W

    1991-01-01

    The effects of a postulated reactor accident at one of the four AGRs at Heysham, NW England, have been studied, assuming a 10% release of the radioactive core. Methods used are a computer program TIRION, analysis of the radiation doses from the Chernobyl release of 1986 and the Windscale fire of 1957. Fatal cases predicted are 200 on-site, 3000 within 30 km and 250,000 in the cloud paths over Northern England. The results would suggest the incidence of fatal cancer would increase from roughly 20% to 27% in the postulated exposed population of 3.6 million.

  11. Initiation and early evolution of the Franklin magmatic event preserved in the 720 Ma Natkusiak Formation, Victoria Island, Canadian Arctic

    NASA Astrophysics Data System (ADS)

    Williamson, Nicole M. B.; Ootes, Luke; Rainbird, Robert H.; Bédard, Jean H.; Cousens, Brian

    2016-03-01

    Our understanding of the onset and evolution of flood basalt volcanism is rooted in the study of the character and internal architecture of its eruptive products. Neoproterozoic continental flood basalts of the ca. 720 Ma Franklin magmatic event are preserved as the Natkusiak Formation and are exposed within the Minto Inlier on Victoria Island, Northwest Territories, Canada. The 200 m volcanic succession evaluated in this study has features similar to those of other continental flood basalt provinces and consists of four volcanic units: a basal unit of laterally discontinuous flows with evidence for lava-sediment interactions, a mafic volcaniclastic deposit emplaced as a mass flow, a quartz-rich volcanic sandstone that records the re-establishment of small river channels, and a unit of thick, high-titanium tholeiitic sheet flows that mark the onset of the main phase of flood volcanism. The basal units show marked lateral thickness variations that imply the existence of paleotopography during their eruption and/or deposition. In addition, two newly discovered volcanic vent complexes within the Natkusiak succession preserve the products of explosive, vent-forming basaltic pyroclastic fall eruptions. Differences in major element geochemistry between the basal and upper basaltic flow units, in conjunction with the lithological characteristics of each volcanic unit, are used to correlate the units on a scale of over 100 km from the south of the Minto Inlier to the north.

  12. Coupled prediction of flood response and debris flow initiation during warm- and cold-season events in the Southern Appalachians, USA

    NASA Astrophysics Data System (ADS)

    Tao, J.; Barros, A. P.

    2014-01-01

    Debris flows associated with rainstorms are a frequent and devastating hazard in the Southern Appalachians in the United States. Whereas warm-season events are clearly associated with heavy rainfall intensity, the same cannot be said for the cold-season events. Instead, there is a relationship between large (cumulative) rainfall events independently of season, and thus hydrometeorological regime, and debris flows. This suggests that the dynamics of subsurface hydrologic processes play an important role as a trigger mechanism, specifically through soil moisture redistribution by interflow. We further hypothesize that the transient mass fluxes associated with the temporal-spatial dynamics of interflow govern the timing of shallow landslide initiation, and subsequent debris flow mobilization. The first objective of this study is to investigate this relationship. The second objective is to assess the physical basis for a regional coupled flood prediction and debris flow warning system. For this purpose, uncalibrated model simulations of well-documented debris flows in headwater catchments of the Southern Appalachians using a 3-D surface-groundwater hydrologic model coupled with slope stability models are examined in detail. Specifically, we focus on two vulnerable headwater catchments that experience frequent debris flows, the Big Creek and the Jonathan Creek in the Upper Pigeon River Basin, North Carolina, and three distinct weather systems: an extremely heavy summertime convective storm in 2011; a persistent winter storm lasting several days; and a severe winter storm in 2009. These events were selected due to the optimal availability of rainfall observations; availability of detailed field surveys of the landslides shortly after they occurred, which can be used to evaluate model predictions; and because they are representative of events that cause major economic losses in the region. The model results substantiate that interflow is a useful prognostic of conditions

  13. Reconstituting Initial Events during the Assembly of ApoB-containing Lipoproteins in a Cell-free System

    PubMed Central

    Jiang, Z. Gordon; Liu, Yuhang; Hussain, M. Mahmood; Atkinson, David; McKnight, C. James

    2008-01-01

    Summary The synthesis of apolipoprotein B (apoB) dictates the formation of chylomicrons and very low density lipoproteins (VLDL), two major lipoprotein precursors in the human plasma. Despite its biological significance, the mechanism of the assembly of these apoB-containing lipoproteins remains elusive. An essential obstacle is the lack of systems that allow fine dissection of key components during assembly, including nascent apoB peptide, lipids in defined forms, chaperones, and microsomal triglyceride transfer protein (MTP). In this study, we use a prokaryotic cell-free expression system to reconstitute early events in the assembly of apoB-containing lipoprotein that involve the N-terminal domains of apoB. Our study shows that the N-terminal domains larger than 20.5% of apoB (B20.5) have an intrinsic ability to remodel vesicular phospholipid bilayers into discrete protein-lipid complexes. The presence of appropriate lipid substrates during apoB translation plays a pivotal role for successful lipid recruitment, and similar lipid recruitment fails to occur if the lipids are added posttranslationally. Cotranslational presence of MTP can dramatically promote the folding of B6.4–20.5 and B6.4–22. Furthermore, apoB translated in the presence of MTP retains its phospholipid recruitment capability posttranslationally. Our data suggest that during the synthesis of apoB, the N-terminal domain has a short window for intrinsic phospholipid recruitment, the timeframe of which is predetermined by the environment where apoB synthesis occurs. The presence of MTP prolongs this window of time by acting as a chaperone. The absence of either proper lipid substrate or MTP may result in the improper folding of apoB and consequently its degradation. PMID:18804479

  14. How a Small Change in Retinal Leads to G-Protein Activation: Initial Events Suggested by Molecular Dynamics Calculations

    PubMed Central

    Crozier, Paul S.; Stevens, Mark J.; Woolf, Thomas B.

    2010-01-01

    Rhodopsin is the prototypical G-protein coupled receptor, coupling light activation with high efficiency to signaling molecules. The dark-state X-ray structures of the protein provide a starting point for consideration of the relaxation from initial light activation to conformational changes that may lead to signaling. In this study we create an energetically unstable retinal in the light activated state and then use molecular dynamics simulations to examine the types of compensation, relaxation, and conformational changes that occur following the cis–trans light activation. The results suggest that changes occur throughout the protein, with changes in the orientation of Helices 5 and 6, a closer interaction between Ala 169 on Helix 4 and retinal, and a shift in the Schiff base counterion that also reflects changes in sidechain interactions with the retinal. Taken together, the simulation is suggestive of the types of changes that lead from local conformational change to light-activated signaling in this prototypical system. PMID:17109408

  15. A Postulated Mechanism That Leads to Materialization and Dematerialization of Matter and to Antigravity.

    ERIC Educational Resources Information Center

    Bearden, Thomas E.

    This document presents a discussion of the postulated mechanism that leads to the materialization and dematerialization of matter and to antigravity. The mechanism also explains why an orbital electron does not radiate energy, in contradiction to classical electromagnetic theory. One of the paradoxes of special relativity is explained. A new model…

  16. Free Radical Halogenation, Selectivity, and Thermodynamics: The Polanyi Principle and Hammond's Postulate

    ERIC Educational Resources Information Center

    Scala, Alfred A.

    2004-01-01

    The underlying ideas of the Polanyi principle and Hammond's postulate in relation to the simple free halogenation reactions and their selectivity and thermodynamics is presented. The results indicate that the chlorine atom exhibits a slightly less selectivity in the liquid phase as compared to in the gas phase.

  17. Fun Microbiology: Using a Plant Pathogenic Fungus To Demonstrate Koch's Postulates.

    ERIC Educational Resources Information Center

    Mitchell, James K.; Orsted, Kathy M.; Warnes, Carl E.

    1997-01-01

    Describes an experiment using a plant pathogenic fungus in which students learn to follow aseptic techniques, grow and produce spores of a fungus, use a hemacytometer for enumerating spores, prepare serial dilutions, grow and inoculate plants, isolate a pure culture using agar streak plates, and demonstrate the four steps of Koch's postulates.…

  18. An Inexpensive and Safe Experiment to Demonstrate Koch's Postulates Using Citrus Fruit

    ERIC Educational Resources Information Center

    Jakobi, Steven

    2010-01-01

    Citrus fruit (oranges, tangerines, grapefruit or lemons) purchased in a grocery store can be experimentally infected with readily-available sources of "Penicillium digitatum" to demonstrate the four basic steps of Koch's postulates, also known as proof of pathogenicity. The mould is isolated from naturally-infected citrus fruit into pure culture…

  19. A Mechanistic Study of a-Amino Acid-N-Carboxy Anhydride Polymerization: Comparing Initiation and Termination Events in High Vacuum and Traditional Polymerization Techniques

    SciTech Connect

    Pickel, Deanna L; Politakos, Nikolaos; Avgeropoulos, Apostolos; Messman, Jamie M

    2009-01-01

    High-vacuum polymerization of -amino acid-N-carboxyanhydride (NCAs) affords polymers with controlled molecular weights and narrow polydispersities, however a comprehensive study of the end-group composition of the resulting poly(amino acid)s has not yet been performed. This reveals crucial information, as the end-groups are indicative of both the polymerization mechanism (i.e., initiation event) as well as the termination pathways. To this end, poly(O-benzyl-L-tyrosine) initiated by 1,6-diaminohexane was synthesized and subsequently characterized by MALDI-TOF MS, NALDI -TOF MS and 13C NMR spectroscopy to ascertain the end-group structure. Polymers were prepared by both high vacuum and glove box techniques in DMF/THF. Preparation of poly(O-benzyl-L-tyrosine) by high vacuum techniques yielded a polymer initiated exclusively by the normal amine mechanism, and termination by reaction with DMF was observed. In contrast, polymers prepared in the glove box were initiated by the normal amine and activated monomer mechanisms, and several termination products are evident. To our knowledge, this is the first rigorous and comparative analysis of the end-group structure, and it demonstrates the advantage of high vacuum techniques for polymerization of NCAs for the preparation of well-defined poly(amino acid)s with end-group fidelity.

  20. Measuring trauma and stressful events in childhood and adolescence among patients with first-episode psychosis: Initial factor structure, reliability, and validity of the Trauma Experiences Checklist

    PubMed Central

    Cristofaro, Sarah L.; Cleary, Sean D.; Wan, Claire Ramsay; Broussard, Beth; Chapman, Colby; Haggard, Patrick J.; Jananeh, Sara; Myers, Neely L.; Compton, Michael T.

    2013-01-01

    Past trauma and stressful events, especially in childhood and adolescence, are common among individuals with serious mental illnesses like schizophrenia. Traumatic experiences are thought to be a socio-environmental risk factor not only for poorer outcomes, but also potentially for the onset of these disorders. Because improved measurement tools are needed, we developed and studied, among 205 first-episode psychosis patients, the factor structure, internal consistency reliability, and initial validity of the Trauma Experiences Checklist (TEC), our measure of trauma and stressful events during childhood/adolescence. We assessed validity of subscales using correlations with Childhood Trauma Questionnaire-Short Form, Parental Harsh Discipline, Violence Exposure, and TEC-Informant Version scores. Exploratory factor analysis resulted in two internally consistent subscales (Cronbach’s =0.79 and 0.80, respectively), interpersonal abuse and family stress, and violence, death, and legal involvement. Scores from the former subscale were substantially associated with CTQ-SF physical, emotional, and sexual abuse (r=0.42–0.57, all p<0.001) and Violence Exposure (r=0.49, p<0.001). On the other hand, violence, death, and legal involvement scores were most highly correlated with Violence Exposure (r=0.49, p<0.001), and not with most CTQ-SF subscales. The TEC is a potentially useful tool in assessing diverse traumatic life events across various social contexts during childhood and adolescence. PMID:23850437

  1. Initial Results on the Meteoritic Component of new Sediment Cores Containing Deposits of the Eltanin Impact Event

    NASA Technical Reports Server (NTRS)

    Kyte, Frank T.; Gersonde, Rainer; Kuhn, Gerhard

    2002-01-01

    The late Pliocene impact of the Eltanin asteroid is the only known asteroid impact in a deep- ocean (-5 km) basin . This was first discovered in 1981 as an Ir anomaly in sediment cores collected by the USNS Eltanin in 1965. In 1995, Polarstern expedition ANT XII/4 made the first geological survey of the suspected impact region. Three sediment cores sampled around the San Martin seamounts (approx. 57.5 S, 91 W) contained well-preserved impact deposits that include disturbed ocean sediments and meteoritic impact ejecta. The latter is composed of shock-melted asteroidal materials and unmelted meteorites. In 2001, the FS Polarstern returned to the impact area during expedition ANT XVIIU5a. At least 16 cores were recovered that contain ejecta deposits. These cores and geophysical data from the expedition can be used to map the effects of the impact over a region of about 80,000 square km. To date we have measured Ir concentrations in sediments from seven of the new cores and preliminary data should be available for a few more by the time of the meeting. Our initial interpretation of these data is that there is a region in the vicinity of the San Martin Seamounts comprising at least 20,000 square km in which the average amount of meteoritic material deposited was more than 1 g per square cm. This alone is enough material to support a 500 m asteroid. Beyond this is a region of about 60,000 square km, mostly to the north and west, where the amount of ejecta probably averages about 0.2 g per square cm. Another 400 km to the east, USNS Eltanin core E10-2 has about 0.05 g per square cm, so we know that ejecta probably occurs across more than a million square km of ocean floor. A key to future exploration of this impact is to find evidence of the ejecta at more sites distant from the seamounts. We currently have almost no data from regions to the west or south of the San Martin seamounts.

  2. Kidney Function and Cardiovascular Events in Postmenopausal Women: The Impact of Race and Ethnicity in the Women’s Health Initiative

    PubMed Central

    Arce, Cristina M.; Rhee, Jinnie J.; Cheung, Katharine L.; Hedlin, Haley; Kapphahn, Kristopher; Franceschini, Nora; Kalil, Roberto S.; Martin, Lisa W.; Qi, Lihong; Shara, Nawar M.; Desai, Manisha; Stefanick, Marcia L.; Winkelmayer, Wolfgang C.

    2015-01-01

    Background Kidney disease disproportionately affects minority populations including African Americans and Hispanics; therefore, understanding the relationship of kidney function to cardiovascular (CV) outcomes within different racial/ethnic groups is of considerable interest. We investigated the relationship between kidney function and CV events and assessed effect modification by race/ethnicity in the Women’s Health Initiative. Study Design Prospective cohort study Setting & Participants Baseline serum creatinine concentrations (assay traceable to isotope-dilution mass spectrometry standard) of 19,411 postmenopausal women aged 50–79 years who self-identified as either non-Hispanic white (n=8921), African American (n=7436), or Hispanic (n=3054) were used to calculate estimated glomerular filtration rates (eGFRs). Predictors Categories of eGFR (exposure); race/ethnicity (effect modifier). Outcomes The primary outcome was the composite of three physician-adjudicated CV events: myocardial infarction (MI), stroke, or CV-related death. Measurements We evaluated the multivariable-adjusted associations between categories of eGFR and CV events using proportional hazards regression and formally tested for effect modification by race/ethnicity. Results Over a mean follow-up of 7.6 years, 1424 CV events (653 MI, 627 strokes, 297 CV-related deaths) were observed. The association between eGFR and CV events was curvilinear; however, the association of eGFR with CV outcomes differed by race (P=0.006). In stratified analyses, we observed that the U-shaped association was present in non-Hispanic whites, whereas African American participants had a rather curvilinear relationship with lower eGFR being associated with higher CV risk and higher eGFR with reduced CV risk. Analyses among Hispanic women were inconclusive owing to few Hispanic women having very low or high eGFR and very few events occurring in these categories. Limitations Lack of urinary albumin measurements; residual

  3. Alternative splicing within the elk-1 5' untranslated region serves to modulate initiation events downstream of the highly conserved upstream open reading frame 2.

    PubMed

    Rahim, Gwendoline; Araud, Tanguy; Jaquier-Gubler, Pascale; Curran, Joseph

    2012-05-01

    The 5' untranslated region (UTR) plays a central role in the regulation of mammalian translation initiation. Key components include RNA structure, upstream AUGs (uAUGs), upstream open reading frames (uORFs), and internal ribosome entry site elements that can interact to modulate the readout. We previously reported the characterization of two alternatively spliced 5' UTR isoforms of the human elk-1 gene. Both contain two uAUGs and a stable RNA stem-loop, but the long form (5' UTR(L)) was more repressive than the short form (5' UTR(S)) for initiation at the ELK-1 AUG. We now demonstrate that ELK-1 expression arises by a combination of leaky scanning and reinitiation, with the latter mediated by the small uORF2 conserved in both spliced isoforms. In HEK293T cells, a considerable fraction of ribosomes scans beyond the ELK-1 AUG in a reinitiation mode. These are sequestered by a series of out-of-frame AUG codons that serve to prevent access to a second in-frame AUG start site used to express short ELK-1 (sELK-1), an N-terminally truncated form of ELK-1 that has been observed only in neuronal cells. We present evidence that all these events are fine-tuned by the nature of the 5' UTR and the activity of the α subunit of eukaryotic initiation factor 2 and provide insights into the neuronal specificity of sELK-1 expression.

  4. Supplementary documentation for an Environmental Impact Statement regarding the Pantex Plant: dispersion analysis for postulated accidents

    SciTech Connect

    Dewart, J.M.; Bowen, B.M.; Elder, J.C.

    1982-12-01

    This report documents work performed in support of preparation of an Environmental Impact Statement (EIS) regarding the Department of Energy (DOE) Pantex Plant near Amarillo, Texas. The report covers the calculation of atmospheric dispersion and deposition of plutonium following postulated nonnuclear detonations of nuclear weapons. Downwind total integrated air concentrations and ground deposition values for each postulated accident are presented. The model used to perform these calculations is the DIFOUT model, developed at Sandia National Laboratories in conjunction with Operation Roller Coaster, a field experiment involving sampling and measurements of nuclear material dispersed by four detonations. The DIFOUT model is described along with the detonation cloud sizes, aerosol parameters, and meteorological data used as input data. A verification study of the DIFOUT model has also been performed; the results are presented.

  5. Design basis for protection of light water nuclear power plants against effects of postulated pipe rupture

    SciTech Connect

    Not Available

    1981-01-01

    This standard addresses the design bases for light water reactor, nuclear power plant structures and components essential for the protection of public health and safety from the potential adverse effects of pipe whip, jet impingement, pressurization of compartments outside containment, environmental conditions and flooding associated with a postulated pipe rupture. The design bases for missile protection and the design bases for containment pressurization are not within this standard.

  6. Higher-order interference and single-system postulates characterizing quantum theory

    NASA Astrophysics Data System (ADS)

    Barnum, Howard; Müller, Markus P.; Ududec, Cozmin

    2014-12-01

    We present a new characterization of quantum theory in terms of simple physical principles that is different from previous ones in two important respects: first, it only refers to properties of single systems without any assumptions on the composition of many systems; and second, it is closer to experiment by having absence of higher-order interference as a postulate, which is currently the subject of experimental investigation. We give three postulates—no higher-order interference, classical decomposability of states, and strong symmetry—and prove that the only non-classical operational probabilistic theories satisfying them are real, complex, and quaternionic quantum theory, together with three-level octonionic quantum theory and ball state spaces of arbitrary dimension. Then we show that adding observability of energy as a fourth postulate yields complex quantum theory as the unique solution, relating the emergence of the complex numbers to the possibility of Hamiltonian dynamics. We also show that there may be interesting non-quantum theories satisfying only the first two of our postulates, which would allow for higher-order interference in experiments while still respecting the contextuality analogue of the local orthogonality principle.

  7. The impact of Westerly wind bursts and ocean initial state on the development and diversity of El Niño events

    NASA Astrophysics Data System (ADS)

    Hu, S.; Fedorov, A. V.; Lengaigne, M.; Guilyardi, E.

    2013-12-01

    Westerly wind bursts (WWBs) that occur in the tropical Pacific near the Dateline are believed to play an important role in the development of El Niño events, even though the direct link is sometimes difficult to establish. Here, following the study of Lengaigne et al. (2004), we conduct numerical simulations in which we reexamine the response of the climate system to an observed wind burst added to a coupled model. Two sets of ensemble experiments are conducted. In the first set, the initial ocean heat content of the system is higher than the model climatology (or recharged), while in the second set it is nearly normal (neutral). For the recharged state, in the absence of WWBs, a moderate central Pacific El Niño (CP) develops in about a year. In contrast, for the neutral state, there develops a weak La Niña. However, when the WWB is imposed, the situation changes dramatically: the recharged state slides into an eastern Pacific El Niño (EP), while the neutral set shifts into a weak CP El Niño instead of previous La Niña conditions. The different response of the system to the exact same perturbations is controlled by the initial state of the ocean and the subsequent ocean-atmosphere interactions involving an interplay between the eastward shift of the warm pool and the warming of the eastern equatorial Pacific. Consequently, the occurrence of different flavors of El Niño, including extreme events, may depend on stochastic atmospheric processes, modulating El Niño properties within a broad continuum.

  8. Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides

    PubMed Central

    Egan, Jan B.; Shi, Chang-Xin; Tembe, Waibhav; Christoforides, Alexis; Kurdoglu, Ahmet; Sinari, Shripad; Middha, Sumit; Asmann, Yan; Schmidt, Jessica; Braggio, Esteban; Keats, Jonathan J.; Fonseca, Rafael; Bergsagel, P. Leif; Craig, David W.; Carpten, John D.

    2012-01-01

    The longitudinal evolution of a myeloma genome from diagnosis to plasma cell leukemia has not previously been reported. We used whole-genome sequencing (WGS) on 4 purified tumor samples and patient germline DNA drawn over a 5-year period in a t(4;14) multiple myeloma patient. Tumor samples were acquired at diagnosis, first relapse, second relapse, and end-stage secondary plasma cell leukemia (sPCL). In addition to the t(4;14), all tumor time points also shared 10 common single-nucleotide variants (SNVs) on WGS comprising shared initiating events. Interestingly, we observed genomic sequence variants that waxed and waned with time in progressive tumors, suggesting the presence of multiple independent, yet related, clones at diagnosis that rose and fell in dominance. Five newly acquired SNVs, including truncating mutations of RB1 and ZKSCAN3, were observed only in the final sPCL sample suggesting leukemic transformation events. This longitudinal WGS characterization of the natural history of a high-risk myeloma patient demonstrated tumor heterogeneity at diagnosis with shifting dominance of tumor clones over time and has also identified potential mutations contributing to myelomagenesis as well as transformation from myeloma to overt extramedullary disease such as sPCL. PMID:22529291

  9. A Numerical Model of CME Initiation and Shock Development for the 1998 May 2 Event: Implications for the Acceleration of GeV Protons

    NASA Astrophysics Data System (ADS)

    Roussev, I. I.; Sokolov, I. V.; Forbes, T. G.; Gombosi, T. I.; Lee, M. A.

    2004-05-01

    We present modeling results on the initiation and evolution of the coronal mass ejection which occurred on 1998 May 2 in NOAA AR8210. This is done within the framework of a global model of the solar magnetic field as it was observed by the Wilcox Solar Observatory. Our calculations are fully three-dimensional and involve compressible magnetohydrodynamics. We begin by first producing a steady-state solar wind for Carrington Rotation 1935/6. The solar eruption is initiated by slowly evolving the boundary conditions until a critical point is reached where the configuration loses mechanical equilibrium. As this point, the field erupts, and a flux rope is ejected away from the Sun, reaching a maximum speed in excess of 1,000 km/s. The shock that forms in front of the rope reaches a fast-mode Mach number in excess of 4 and a compression ratio greater than 3 by the time it has traveled a distance of 5 solar radii from the surface. Thus, by constructing a fully three-dimensional numerical model, which incorporates magnetic field data and a loss-of-equilibrium mechanism, we have been able to demonstrate that a shock can develop close to the Sun sufficiently strong to account for the energization of solar particles. For this event, diffusive-shock-acceleration theory predicts a distribution of solar energetic protons with a cut-off energy of about 10 GeV.

  10. Risk of cardiovascular events after initiation of long-acting bronchodilators in patients with chronic obstructive lung disease: A population-based study

    PubMed Central

    Aljaafareh, Almotasembellah; Valle, Jose Ruben; Lin, Yu-Li; Kuo, Yong-Fang; Sharma, Gulshan

    2016-01-01

    Objectives: Long-acting bronchodilators are mainstay treatment for moderate to severe chronic obstructive pulmonary disease. A growing body of evidence indicates an increased risk of cardiovascular events upon initiation of these medications. We hypothesize that this risk is higher in patients with chronic obstructive pulmonary disease who had a preexisting cardiovascular disease regardless of receipt of any cardiovascular medication. Methods: A retrospective cohort of patients with a diagnosis of chronic obstructive pulmonary disease based on two outpatient visits or one inpatient visit for chronic obstructive pulmonary disease (International Classification of Diseases, 9th Edition, Clinical Modification codes 491.x, 492.x, 496) in any year between 2001 and 2012 from a commercial insurance database. We then selected those initiating long-acting bronchodilator treatments between April 2001 and September 2012. Each patient had a 1 year look back period to determine history of cardiovascular disease or cardiovascular disease treatment from the time of first prescription of long-acting beta agonist, long-acting muscarinic antagonist, or long-acting beta agonist combined with inhaled corticosteroids. Patients were followed for 90 days for hospitalizations or emergency department visits for cardiovascular event. The cohort was divided into four groups based on the presence of cardiovascular disease (including ischemic heart disease, hypertension, ischemic stroke, heart failure, tachyarrhythmias and artery disease based on International Classification of Diseases, 9th Edition, Clinical Modification codes) and cardiovascular disease treatment defined as acetylsalicylic acid, beta blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antiplatelet, anticoagulants, calcium channel blockers, nitrate, digoxin, diuretics, antiarrhythmics or statins. Odds of emergency department visit or hospitalization in the 90 days after prescription were

  11. The Light-Velocity Postulate: The Essential Difference between the Theories of Lorentz-Poincare and Einstein

    ERIC Educational Resources Information Center

    Abiko, Seiya

    2005-01-01

    Einstein, who had already developed the light-quantum theory, knew the inadequacy of Maxwell's theory in the microscopic sphere. Therefore, in writing his paper on special relativity, he had to set up the light-velocity postulate independently of the relativity postulate in order to make the electromagnetic foundation of physics compatible with…

  12. News Conference: The Big Bangor Day Meeting Lecture: Charterhouse plays host to a physics day Festival: Science on Stage festival 2013 arrives in Poland Event: Scottish Physics Teachers' Summer School Meeting: Researchers and educators meet at Lund University Conference: Exeter marks the spot Recognition: European Physical Society uncovers an historic site Education: Initial teacher education undergoes big changes Forthcoming events

    NASA Astrophysics Data System (ADS)

    2013-09-01

    Conference: The Big Bangor Day Meeting Lecture: Charterhouse plays host to a physics day Festival: Science on Stage festival 2013 arrives in Poland Event: Scottish Physics Teachers' Summer School Meeting: Researchers and educators meet at Lund University Conference: Exeter marks the spot Recognition: European Physical Society uncovers an historic site Education: Initial teacher education undergoes big changes Forthcoming events

  13. Analysis of radiation doses from operation of postulated commercial spent fuel transportation systems: Main report

    SciTech Connect

    Schneider, K.J.; Hostick, C.J.; Ross, W.A.; Peterson, R.W.; Smith, R.I.; Stiles, D.L.; Daling, P.M.; Weakley, S.A.; Grinde, R.B.; Young, J.R.

    1987-11-01

    This report contains a system study of estimated radiation doses to the public and workers resulting from the transport of spent fuel from commercial nuclear power reactors to a geologic repository. The report contains a detailed breakdown of activities and a description of time/distance/dose-rate estimates for each activity within the system. Collective doses are estimated for each of the major activities at the reactor site, in transit, and at the repository receiving facility. Annual individual doses to the maximally exposed individuals or groups of individuals are also estimated. A total of 17 alternatives and subalternatives to the postulated reference transportation system are identified, conceptualized, and their dose-reduction potentials and costs estimated. Resulting ratios of ..delta..cost/..delta..collective system dose for each alternative relative to the postulated reference transportation system are given. Most of the alternatives evaluated are estimated to provide both cost and dose reductions. Major reductions in transportation system dose and cost are estimated to result from using higher-capacity rail and truck casks, and particularly when replacing legalweight truck casks with ''advanced design'' overweight truck casks. The greatest annual dose reduction to the highest exposed individual workers (i.e., at the repository) is estimated to be achieved by using remote handling equipment for the cask handling operations at the repository. Additional shielding is also effective in reducing doses to both radiation workers at the reactor and repository and to transport workers. 69 refs., 36 figs., 156 tabs.

  14. Effect of Microgravity on Early Events of Biological Nitrogen Fixation in Medicago Truncatula: Initial Results from the SyNRGE Experiment

    NASA Technical Reports Server (NTRS)

    Stutte, Gary W.; Roberts, Michael S.

    2011-01-01

    SyNRGE (Symbiotic Nodulation in a Reduced Gravity Environment) was a sortie mission on STS-135 in the Biological Research in Canisters (BRIC) hardware to study the effect of microgravity on a plant-microbe symbiosis resulting in biological nitrogen fixation. Medicago truncatula, a model species of the legume family, was inoculated with its bacterial symbiont, Sinorhizobium meliloti, to observe early events associated with infection and nodulation in Petri Dish Fixation Units (PDFUs). Two sets of experiments were conducted in orbit and in 24-hour delayed ground controls. Experiment one was designed to determine if S. meliloti infect M. truncatula and initiate physiological changes associated with nodule formation. Roots of five-day-old M. truncatula cultivar Jemalong A17 (Enodll::gus) were inoculated 24 hr before launch with either S. meliloti strain 1021 or strain ABS7 and integrated into BRIC-PDFU hardware placed in a 4 C Cold Bag for launch on Atlantis. Inoculated plants and uninoculated controls were maintained in the dark at ambient temperature in the middeck of STS-135 for 11 days before fixation in RNAlater(tM) by crew activation of the PDFU. Experiment two was designed to determine if microgravity altered the process of bacterial infection and host plant nodule formation. Seeds of two M. truncatula cultivar Jemalong A17 lines, the Enodll::gus used in experiment 1, and SUNN, a super-nodulating mutant of A17, were germinated on orbit for 11 days in the middeck cabin and returned to Earth alive inside of BRIC-PDFU's at 4 C. S. meliloti strains 1021 and ABS7 were cultivated separately in broth culture on orbit and also returned to Earth alive. After landing, flight- and groundgrown plants and bacteria were transferred from BRIC-PDFU's into Nunc(tm) 4-well plates for reciprocity crosses. Rates of plant growth and nodule development on Buffered Nodulation Medium (lacking nitrogen) were measured for 14 days. Preliminary analysis' of Experiment 1 confirms that

  15. Fritz Zwicky's Postulate of Freedom from Prejudice Considered from the Standpoint of the Theory of Knowledge

    NASA Astrophysics Data System (ADS)

    Lutz, Markus

    What can we say about unprejudiced thinking as postulated by Ritz Zwicky? Freedom from prejudice in opposition to stamped by theory. How does knowledge come about? Through sense perception and thought. The phenomenon is always mediated by organs, respectively by technical instruments. Which conclusion can we draw from this fact? Is the organ of knowledge by which we know nature a part of nature? Can the dialectic materialism explain the processes of human consciousness? What is the fundamental difference between think and perceive? Has human consciousness only a share in nature or also in the spiritual world? The role of the observer in the Copenhagen interpretation. Is the quantum theory applicable to psychic phenomena?

  16. Estimation of Downstream Cesium Concentrations Following a Postulated PAR Pond Dam Break

    SciTech Connect

    Chen, K.F.

    2002-07-08

    Following a postulated PAR Pond dam break, some of the PAR Pond sediment including the cesium could be eroded and be transported downstream to the Savannah River through the Lower Three Runs Creek. Studies showed that most of the eroded sediment including the cesium would deposit in the Lower Three Runs Creek and the remainder would discharge to the Savannah River from the mouth of Lower Three Runs Creek. A WASP5 model was developed to simulate the eroded sediment and cesium transport from the Lower Three Runs Creek mouth to the Atlantic coast. The dissolved cesium concentrations at the Highway 301 bridge and near the City of Savannah Industrial and Domestic Water Supply Plant are 30 and 27 pCi/l, respectively. The concentrations at both locations are less than the U. S. Environmental Protection Agency drinking water standard of 200 pCi/l.

  17. OVERVIEW OF MODULAR HTGR SAFETY CHARACTERIZATION AND POSTULATED ACCIDENT BEHAVIOR LICENSING STRATEGY

    SciTech Connect

    Ball, Sydney J

    2014-06-01

    This report provides an update on modular high-temperature gas-cooled reactor (HTGR) accident analyses and risk assessments. One objective of this report is to improve the characterization of the safety case to better meet current regulatory practice, which is commonly geared to address features of today s light water reactors (LWRs). The approach makes use of surrogates for accident prevention and mitigation to make comparisons with LWRs. The safety related design features of modular HTGRs are described, along with the means for rigorously characterizing accident selection and progression methodologies. Approaches commonly used in the United States and elsewhere are described, along with detailed descriptions and comments on design basis (and beyond) postulated accident sequences.

  18. Existence of an information unit as a postulate of quantum theory

    PubMed Central

    Masanes, Lluís; Müller, Markus P.; Augusiak, Remigiusz; Pérez-García, David

    2013-01-01

    Does information play a significant role in the foundations of physics? Information is the abstraction that allows us to refer to the states of systems when we choose to ignore the systems themselves. This is only possible in very particular frameworks, like in classical or quantum theory, or more generally, whenever there exists an information unit such that the state of any system can be reversibly encoded in a sufficient number of such units. In this work, we show how the abstract formalism of quantum theory can be deduced solely from the existence of an information unit with suitable properties, together with two further natural assumptions: the continuity and reversibility of dynamics, and the possibility of characterizing the state of a composite system by local measurements. This constitutes a set of postulates for quantum theory with a simple and direct physical meaning, like the ones of special relativity or thermodynamics, and it articulates a strong connection between physics and information. PMID:24062431

  19. Existence of an information unit as a postulate of quantum theory.

    PubMed

    Masanes, Lluís; Müller, Markus P; Augusiak, Remigiusz; Pérez-García, David

    2013-10-08

    Does information play a significant role in the foundations of physics? Information is the abstraction that allows us to refer to the states of systems when we choose to ignore the systems themselves. This is only possible in very particular frameworks, like in classical or quantum theory, or more generally, whenever there exists an information unit such that the state of any system can be reversibly encoded in a sufficient number of such units. In this work, we show how the abstract formalism of quantum theory can be deduced solely from the existence of an information unit with suitable properties, together with two further natural assumptions: the continuity and reversibility of dynamics, and the possibility of characterizing the state of a composite system by local measurements. This constitutes a set of postulates for quantum theory with a simple and direct physical meaning, like the ones of special relativity or thermodynamics, and it articulates a strong connection between physics and information.

  20. Fission product transport and behavior during two postulated loss of flow transients in the air

    SciTech Connect

    Adams, J.P.; Carboneau, M.L.

    1991-01-01

    This document discusses fission product behavior during two postulated loss-of-flow accidents (leading to high- and low-pressure core degradation, respectively) in the Advanced Test Reactor (ATR). These transients are designated ATR Transient LCPI5 (high-pressure) and LPP9 (low-pressure). Normally, transients of this nature would be easily mitigated using existing safety systems and procedures. In these analyses, failure of these safety systems was assumed so that core degradation and fission product release could be analyzed. A probabilistic risk assessment indicated that the probability of occurrence for these two transients is of the order of 10{sup {minus}5 }and 10{sup {minus}7} per reactor year for LCP15 and LPP9, respectively.

  1. Fission product transport and behavior during two postulated loss of flow transients in the air

    SciTech Connect

    Adams, J.P.; Carboneau, M.L.

    1991-12-31

    This document discusses fission product behavior during two postulated loss-of-flow accidents (leading to high- and low-pressure core degradation, respectively) in the Advanced Test Reactor (ATR). These transients are designated ATR Transient LCPI5 (high-pressure) and LPP9 (low-pressure). Normally, transients of this nature would be easily mitigated using existing safety systems and procedures. In these analyses, failure of these safety systems was assumed so that core degradation and fission product release could be analyzed. A probabilistic risk assessment indicated that the probability of occurrence for these two transients is of the order of 10{sup {minus}5 }and 10{sup {minus}7} per reactor year for LCP15 and LPP9, respectively.

  2. Acute deep brain stimulation in the thalamic reticular nucleus protects against acute stress and modulates initial events of adult hippocampal neurogenesis.

    PubMed

    Magdaleno-Madrigal, Víctor Manuel; Pantoja-Jiménez, Christopher Rodrigo; Bazaldúa, Adrián; Fernández-Mas, Rodrigo; Almazán-Alvarado, Salvador; Bolaños-Alejos, Fernanda; Ortíz-López, Leonardo; Ramírez-Rodriguez, Gerardo Bernabé

    2016-11-01

    Deep brain stimulation (DBS) is used as an alternative therapeutic procedure for pharmacoresistant psychiatric disorders. Recently the thalamic reticular nucleus (TRN) gained attention due to the description of a novel pathway from the amygdala to this nucleus suggesting that may be differentially disrupted in mood disorders. The limbic system is implicated in the regulation of these disorders that are accompanied by neuroplastic changes. The hippocampus is highly plastic and shows the generation of new neurons, process affected by stress but positively regulated by antidepressant drugs. We explored the impact of applying acute DBS to the TRN (DBS-TRN) in male Wistar rats exposed to acute stress caused by the forced-swim Porsolt's test (FST) and on initial events of hippocampal neurogenesis. After the first session of forced-swim, rats were randomly subdivided in a DBS-TRN and a Sham group. Stimulated rats received 10min of DBS, thus the depressant-like behavior reflected as immobility was evaluated in the second session of forced-swim. Locomotricity was evaluated in the open field test. Cell proliferation and doublecortin-associated cells were quantified in the hippocampus of other cohorts of rats. No effects of electrode implantation were found in locomotricity. Acute DBS-TRN reduced immobility in comparison to the Sham group (p<0.001). DBS-TRN increased cell proliferation (Ki67 or BrdU-positive cells; p=0.02, p=0.02) and the number of doublecortin-cells compared to the Sham group (p<0.02). Similar effects were found in rats previously exposed to the first session of forced-swim. Our data could suggest that TRN brain region may be a promising target for DBS to treat intractable depression.

  3. A solution NMR investigation into the early events of amelogenin nanosphere self-assembly initiated with sodium chloride or calcium chloride.

    PubMed

    Buchko, Garry W; Tarasevich, Barbara J; Bekhazi, Jacky; Snead, Malcolm L; Shaw, Wendy J

    2008-12-16

    Using solution-state NMR spectroscopy, new insights into the early events governing amelogenin supramolecular self-assembly have been identified using sodium chloride and calcium chloride to trigger the association. Two-dimensional 1H-15N HSQC spectra were recorded for 15N- and 13C-labeled murine amelogenin as a function of increasing NaCl and CaCl2 concentration beginning with solution conditions of 2% acetic acid at pH 3.0, where amelogenin was monomeric. Residue specific changes in molecular dynamics, manifested by the reduction in intensity and disappearance of 1H-15N HSQC cross-peaks, were observed with the addition of either salt to the protein. With increasing NaCl concentrations, residues between T21 and R31 near the N-terminus were affected first, suggesting that these residues may initiate amelogenin dimerization, the first step in nanosphere assembly. At higher NaCl concentrations, more residues near the N-terminus (Y12-I51) were affected, and with further additions of NaCl, residues near the C-terminus (L141-T171) began to show a similar change in molecular dynamics. With increasing CaCl2 concentrations, a similar stepwise change in molecular dynamics involving essentially the same set of amelogenin residues was observed. As the concentration of either salt was increased, a concomitant increase in the estimated overall rotational correlation time (tau(c)) was observed, consistent with assembly. Self-assembly into a dimer or trimer was established with dynamic light scattering studies under similar conditions that showed an increase in diameter of the smallest species from 4.1 nm in the absence of salt to 10 nm in the presence of salt. These results suggest a possible stepwise interaction mechanism, starting with the N-terminus and followed by the C-terminus, leading to amelogenin nanosphere assembly.

  4. Rapid inhibition of pyruvate dehydrogenase: an initiating event in high dietary fat-induced loss of metabolic flexibility in the heart.

    PubMed

    Crewe, Clair; Kinter, Michael; Szweda, Luke I

    2013-01-01

    Cardiac function depends on the ability to switch between fatty acid and glucose oxidation for energy production in response to changes in substrate availability and energetic stress. In obese and diabetic individuals, increased reliance on fatty acids and reduced metabolic flexibility are thought to contribute to the development of cardiovascular disease. Mechanisms by which cardiac mitochondria contribute to diet-induced metabolic inflexibility were investigated. Mice were fed a high fat or low fat diet for 1 d, 1 wk, and 20 wk. Cardiac mitochondria isolated from mice fed a high fat diet displayed a diminished ability to utilize the glycolytically derived substrate pyruvate. This response was rapid, occurring within the first day on the diet, and persisted for up to 20 wk. A selective increase in the expression of pyruvate dehydrogenase kinase 4 and inhibition of pyruvate dehydrogenase are responsible for the rapid suppression of pyruvate utilization. An important consequence is that pyruvate dehydrogenase is sensitized to inhibition when mitochondria respire in the presence of fatty acids. Additionally, increased expression of pyruvate dehydrogenase kinase 4 preceded any observed diet-induced reductions in the levels of glucose transporter type 4 and glycolytic enzymes and, as judged by Akt phosphorylation, insulin signaling. Importantly, diminished insulin signaling evident at 1 wk on the high fat diet did not occur in pyruvate dehydrogenase kinase 4 knockout mice. Dietary intervention leads to a rapid decline in pyruvate dehydrogenase kinase 4 levels and recovery of pyruvate dehydrogenase activity indicating an additional form of regulation. Finally, an overnight fast elicits a metabolic response similar to that induced by high dietary fat obscuring diet-induced metabolic changes. Thus, our data indicate that diet-induced inhibition of pyruvate dehydrogenase may be an initiating event in decreased oxidation of glucose and increased reliance of the heart on

  5. Transient behavior of a scaled RCCS test facility under postulated fault and accident scenarios

    SciTech Connect

    Lisowski, Darius D.; Hu, Rui; Bucknor, Matthew D.; Gerardi, Craig D.; Farmer, Mitch T.

    2016-01-01

    Tests were performed on the Natural convection Shutdown heat removal Test Facility (NSTF) to simulate design basis accident and postulated fault scenarios. Residing at Argonne National Laboratory, the NSTF stands nearly 26-m in total height and reflects a ½ scale reactor cavity cooling system (RCCS) for high temperature gas cooled reactors. The following manuscript details three test conditions performed on the experimental test facility. The first simulated the reactor pressure vessel (RPV) boundary condition during depressurized conduction cool down accident with small primary leak, and was repeated during both winter and summer seasons. The second examined a short-circuit break between the inlet and outlet flow paths, and was performed in three incremental stages of nominal flow area break size. The third and final test case studied system behavior with varying amounts of cooling channel blockages, up to and including 50% flow areas. Nominal component temperatures, heat removal performance, and system stability will be presented to characterize the behavior at these conditions.

  6. Fulfilling Koch's postulates confirms the mycotic origin of Lethargic Crab Disease.

    PubMed

    Orélis-Ribeiro, Raphael; Boeger, Walter A; Vicente, Vânia A; Chammas, Marcelo; Ostrensky, Antonio

    2011-03-01

    In the northeast region of the Brazilian coast, a disease has been causing massive mortalities of populations of the mangrove land crab, Ucides cordatus (L.) since 1997. The clinical signs of this disease, which include lethargy and ataxia, led to the disease being termed Lethargic Crab Disease (LCD). Evidence from a variety of sources indicates that there is an association between LCD and a new species of black yeast, Exophiala cancerae de Hoog, Vicente, Najafzadeh, Badali, Seyedmousavi & Boeger. This study tests this putative correlation through in vivo experiments. Disease-free specimens of U. cordatus were experimentally infected with Exophiala cancerae (strain CBS 120420) isolate. During the 30-day experimental period, only a single death was observed within the control crabs. However, at the end of this period, crabs that were inoculated once or three-times with mycelial elements and hyphae of E. cancerae had a 60% and 50% mortality rates, respectively (n = 6 and n = 5). These results support that the fungal agent is pathogenic and is the causative agent of LCD. Species-specific molecular markers confirm the presence of E. cancerae (strain CBS 120420) in recovered colonies and tissue samples from the infected animals. The experimentally infected crabs manifested signs (lethargy, ataxia and tetany) that were consistent to LCD-affected animals in the environment. These results fulfil Koch's postulates and the hypothesis that the tested strain of Exophiala cancerae is a causative agent of LCD is accepted.

  7. Analysis of pressurization of plutonium oxide storage vials during a postulated fire

    SciTech Connect

    Laurinat, J.; Kesterson, M.; Hensel, S.

    2015-02-10

    The documented safety analysis for the Savannah River Site evaluates the consequences of a postulated 1000 °C fire in a glovebox. The radiological dose consequences for a pressurized release of plutonium oxide powder during such a fire depend on the maximum pressure that is attained inside the oxide storage vial. To enable evaluation of the dose consequences, pressure transients and venting flow rates have been calculated for exposure of the storage vial to the fire. A standard B vial with a capacity of approximately 8 cc was selected for analysis. The analysis compares the pressurization rate from heating and evaporation of moisture adsorbed onto the plutonium oxide contents of the vial with the pressure loss due to venting of gas through the threaded connection between the vial cap and body. Tabulated results from the analysis include maximum pressures, maximum venting velocities, and cumulative vial volumes vented during the first 10 minutes of the fire transient. Results are obtained for various amounts of oxide in the vial, various amounts of adsorbed moisture, different vial orientations, and different surface fire exposures.

  8. Assessment of potential doses to workers during postulated accident conditions at the Waste Isolation Pilot Plant

    SciTech Connect

    Hoover, M.D.; Farrell, R.F.; Newton, G.J.

    1995-12-01

    The recent 1995 WIPP Safety Analysis Report (SAR) Update provided detailed analyses of potential radiation doses to members of the public at the site boundary during postulated accident scenarios at the U.S. Department of Energy`s Waste Isolation Pilot Plant (WIPP). The SAR Update addressed the complete spectrum of potential accidents associated with handling and emplacing transuranic waste at WIPP, including damage to waste drums from fires, punctures, drops, and other disruptions. The report focused on the adequacy of the multiple layers of safety practice ({open_quotes}defense-in-depth{close_quotes}) at WIPP, which are designed to (1) reduce the likelihood of accidents and (2) limit the consequences of those accidents. The safeguards which contribute to defense-in-depth at WIPP include a substantial array of inherent design features, engineered controls, and administrative procedures. The SAR Update confirmed that the defense-in-depth at WIPP is adequate to assure the protection of the public and environment. As a supplement to the 1995 SAR Update, we have conducted additional analyses to confirm that these controls will also provide adequate protection to workers at the WIPP. The approaches and results of the worker dose assessment are summarized here. In conformance with the guidance of DOE Standard 3009-94, we emphasize that use of these evaluation guidelines is not intended to imply that these numbers constitute acceptable limits for worker exposures under accident conditions. However, in conjunction with the extensive safety assessment in the 1995 SAR Update, these results indicate that the Carlsbad Area Office strategy for the assessment of hazards and accidents assures the protection of workers, members of the public, and the environment.

  9. A Rare Occurrence of Simultaneous Venous and Arterial Thromboembolic Events – Lower Limb Deep Venous Thrombosis and Pulmonary Thromboembolism as Initial Presentation in Acute Promyelocytic Leukemia

    PubMed Central

    Kutiyal, Aditya S.; Dharmshaktu, Pramila; Kataria, Babita; Garg, Abhilasha

    2016-01-01

    The development of acute myeloid leukemia has been attributed to various factors, including hereditary, radiation, drugs, and certain occupational exposures. The association between malignancy and venous thromboembolism events is well established. Here, we present a case of a 70-year-old Indian man who had presented with arterial and venous thrombosis, and the patient was later diagnosed with acute promyelocytic leukemia (APL). In our case, the patient presented with right lower limb deep venous thrombosis and pulmonary thromboembolism four months prior to the diagnosis of APL. Although thromboembolic event subsequent to the diagnosis of malignancy, and especially during the chemotherapy has been widely reported, this prior presentation with simultaneous occurrence of both venous and arterial thromboembolism has rarely been reported. We take this opportunity to state the significance of a complete medical evaluation in cases of recurrent or unusual thrombotic events. PMID:26949347

  10. Events during eucaryotic rRNA transcription initiation and elongation: Conversion from the closed to the open promoter complex requires nucleotide substrates

    SciTech Connect

    Bateman, E.; Paule, M.R.

    1988-05-01

    Chemical footprinting and topological analysis were carried out on the Acanthamoeba castellanii rRNA transcription initiation factor (TIF) and RNA polymerase I complexes with DNA during transcription initiation and elongation. The results show that the binding of TIF and polymerase to the promoter does not alter the supercoiling of the DNA template and the template does not become sensitive to modification by diethylpyro-carbonate, which can identify melted DNA regions. Thus, in contrast to bacterial RNA polymerase, the eucaryotic RNA polymerase I-promoter complex is in a closed configuration preceding addition of nucleotides in vitro. Initiation and 3'-O-methyl CTP-limited translocation by RNA polymerase I results in separation of the polymerase-TIF footprints, leaving the TIF footprint unaltered. In contrast, initiation and translocation result in a significant change in the conformation of the polymerase-DNA complex, culminating in an unwound DNA region of at least 10 base pairs.

  11. Compelling Evidence of the Need for Corporate Work/Life Balance Initiatives: Results from a National Survey of Stressful Life-Events.

    ERIC Educational Resources Information Center

    Hobson, Charles J.; Delunas, Linda; Kesic, Dawn

    2001-01-01

    Considers how failure to balance excessive work and life/family demands can lead to negative consequences for both individuals and organizations, including higher stress levels, increased absenteeism, and lower productivity. Discusses results of a survey on stressful life events that offers an explanation of why work/life balance programs are so…

  12. Event-by-event distribution of the ratio of magnetic field energy to initial fluid energy density in √{sN N}=200 GeV Au-Au collisions

    NASA Astrophysics Data System (ADS)

    Roy, Victor; Pu, Shi

    2015-12-01

    We estimate the event-by-event (e-by-e) distribution of the ratio (σ ) of the magnetic and electric field energy density to the fluid energy density in the transverse plane of Au-Au collisions at √{sN N}=200 GeV. A Monte Carlo (MC) Glauber model is used to calculate σ in the transverse plane for impact parameter b =0 , 12 fm at time τi˜0.5 fm. The fluid energy density is obtained by using Gaussian smoothing with two different smoothing parameter σg=0.25 , 0.5 fm. For b =0 fm collisions σ is found to be ≪1 in the central region of the fireball and σ ≳1 at the periphery. For b =12 fm collisions σ ≳1 is observed for some events. The e-by-e correlation between σ and the fluid energy density (ɛ ) is studied. We did not find strong correlation between σ and ɛ at the center of the fireball, whereas they are mostly anticorrelated at the periphery of the fireball.

  13. Eliciting the child’s voice in adverse event reporting in oncology trials: Cognitive interview findings from the Pediatric Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events initiative

    PubMed Central

    Reeve, Bryce B.; McFatrich, Molly; Pinheiro, Laura C.; Weaver, Meaghann S.; Sung, Lillian; Withycombe, Janice S.; Baker, Justin N.; Mack, Jennifer W.; Waldron, Mia K.; Gibson, Deborah; Tomlinson, Deborah; Freyer, David R.; Mowbray, Catriona; Jacobs, Shana; Palma, Diana; Martens, Christa E.; Gold, Stuart H.; Jackson, Kathryn D.; Hinds, Pamela S.

    2017-01-01

    Background Adverse event (AE) reporting in oncology trials is required, but current practice does not directly integrate the child’s voice. The Pediatric Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) is being developed to assess symptomatic AEs via child/adolescent self-report or proxy-report. This qualitative study evaluates the child’s/adolescent’s understanding and ability to provide valid responses to the PRO-CTCAE to inform questionnaire refinements and confirm content validity. Procedure From seven pediatric research hospitals, children/adolescents ages 7–15 years who were diagnosed with cancer and receiving treatment were eligible, along with their parent-proxies. The Pediatric PRO-CTCAE includes 130 questions that assess 62 symptomatic AEs capturing symptom frequency, severity, interference, or presence. Cognitive interviews with retrospective probing were completed with children in the age groups of 7–8, 9–12, and 13–15 years. The children/adolescents and proxies were interviewed independently. Results Two rounds of interviews involved 81 children and adolescents and 74 parent-proxies. Fifteen of the 62 AE terms were revised after Round 1, including refinements to the questions assessing symptom severity. Most participants rated the PRO-CTCAE AE items as “very easy” or “somewhat easy” and were able to read, understand, and provide valid responses to questions. A few AE items assessing rare events were challenging to understand. Conclusions The Pediatric and Proxy PRO-CTCAE performed well among children and adolescents and their proxies, supporting its content validity. Data from PRO-CTCAE may improve symptomatic AE reporting in clinical trials and enhance the quality of care that children receive. PMID:27650708

  14. Damage initiation and propagation assessed from stress-induced microseismic events during a mine-by test in the Opalinus Clay

    NASA Astrophysics Data System (ADS)

    Le Gonidec, Y.; Sarout, J.; Wassermann, J.; Nussbaum, C.

    2014-07-01

    We report in this paper an original analysis of microseismic events (MSEs) induced by an excavation operation in the clay environment of the Mont Terri underground rock laboratory. In order to identify the MSEs with confidence, we develop a restrictive but efficient multistep method for filtering the recorded events. We deduce the spatial distribution and processes associated with the excavation-induced damage from the spatial location and focal mechanisms of the MSEs. We observe an asymmetric geometry of the excavation damaged zone around the excavated gallery, without notable microseismic activity in the sandy facies sidewall, in contrast with the shaly facies sidewall where a first burst of events is recorded, followed by two smaller bursts: one locates ahead of the excavation front and is associated with a dominant double-couple component, suggesting bedding plane reworking, that is, shear fracture mode, and the MSEs of the other cluster inside the shaly sidewall of the gallery, with a dominant compensated linear vector dipole component, suggesting extensive cracking. We identify and discuss four major factors that seem to control the MSEs source mechanisms: lithology, geometry of the geological features, gallery orientation and direction of the main compressive stress.

  15. Comparative proteomic and biochemical analyses reveal different molecular events occurring in the process of fiber initiation between wild-type allotetraploid cotton and its fuzzless-lintless mutant.

    PubMed

    Yao, Yuan; Zhang, Bing; Dong, Chun-Juan; Du, Ying; Jiang, Lin; Liu, Jin-Yuan

    2015-01-01

    To explore lint fiber initiation-related proteins in allotetraploid cotton (Gossypium hirsutum L.), a comparative proteomic analysis was performed between wild-type cotton (Xu-142) and its fuzzless-lintless mutant (Xu-142-fl) at five developmental time points for lint fiber initiation from -3 to +3 days post-anthesis (dpa). Using two-dimensional gel electrophoresis (2-DE) combined with mass spectrometry (MS) analyses, 91 differentially accumulated protein (DAP) species that are related to fiber initiation were successfully identified, of which 58 preferentially accumulated in the wild-type and 33 species in the fl mutant. These DAPs are involved in various cellular and metabolic processes, mainly including important energy/carbohydrate metabolism, redox homeostasis, amino acid and fatty acid biosynthesis, protein quality control, cytoskeleton dynamics, and anthocyanidin metabolism. Further physiological and biochemical experiments revealed dynamic changes in the carbohydrate flux and H2O2 levels in the cotton fiber initiation process. Compared with those in the fl mutant, the contents of glucose and fructose in wild-type ovules sharply increased after anthesis with a relatively higher rate of amino acid biosynthesis. The relative sugar starvation and lower rate of amino acid biosynthesis in the fl mutant ovules may impede the carbohydrate/energy supply and cell wall synthesis, which is consistent with the proteomic results. However, the H2O2 burst was only observed in the wild-type ovules on the day of anthesis. Cotton boll injection experiments in combination with electron microscope observation collectively indicated that H2O2 burst, which is negatively regulated by ascorbate peroxidases (APx), plays an important role in the fiber initiation process. Taken together, our study demonstrates a putative network of DAP species related to fiber initiation in cotton ovules and provides a foundation for future studies on the specific functions of these proteins in fiber

  16. Aesthetic Response: An Overview of Selected Theories and the Postulation of a Model.

    ERIC Educational Resources Information Center

    King, Alison

    In response to a growing interest among educators in improving aesthetic education, this paper explores aesthetic response, defined as what happens in the mind and body of a person who encounters an aesthetic object or phenomenon. An initial section overviews the major theories of aesthetic response, including the work of Plato, Aristotle, Freud,…

  17. Russian Military and Security Forces: A Postulated Reaction to a Nuclear Detonation

    SciTech Connect

    Ball, D

    2005-04-29

    In this paper, we will examine how Russia's military and security forces might react to the detonation of a 10-kiloton nuclear weapon placed next to the walls surrounding the Kremlin. At the time of this 'big bang,' Putin is situated outside Moscow and survives the explosion. No one claims responsibility for the detonation. No other information is known. Numerous variables will determine how events ultimately unfold and how the military and security forces will respond. Prior to examining these variables in greater detail, it is imperative to elucidate first what we mean by Russia's military and security forces.

  18. Elucidating the role of vegetation in the initiation of rainfall-induced shallow landslides: Insights from an extreme rainfall event in the Colorado Front Range

    NASA Astrophysics Data System (ADS)

    McGuire, Luke A.; Rengers, Francis K.; Kean, Jason W.; Coe, Jeffrey A.; Mirus, Benjamin B.; Baum, Rex L.; Godt, Jonathan W.

    2016-09-01

    More than 1100 debris flows were mobilized from shallow landslides during a rainstorm from 9 to 13 September 2013 in the Colorado Front Range, with the vast majority initiating on sparsely vegetated, south facing terrain. To investigate the physical processes responsible for the observed aspect control, we made measurements of soil properties on a densely forested north facing hillslope and a grassland-dominated south facing hillslope in the Colorado Front Range and performed numerical modeling of transient changes in soil pore water pressure throughout the rainstorm. Using the numerical model, we quantitatively assessed interactions among vegetation, rainfall interception, subsurface hydrology, and slope stability. Results suggest that apparent cohesion supplied by roots was responsible for the observed connection between debris flow initiation and slope aspect. Results suggest that future climate-driven modifications to forest structure could substantially influence landslide hazards throughout the Front Range and similar water-limited environments where vegetation communities may be more susceptible to small variations in climate.

  19. Elucidating the role of vegetation in the initiation of rainfall-induced shallow landslides: Insights from an extreme rainfall event in the Colorado Front Range

    USGS Publications Warehouse

    Mcguire, Luke; Rengers, Francis; Kean, Jason W.; Coe, Jeffrey A.; Mirus, Benjamin B.; Baum, Rex L.; Godt, Jonathan W.

    2016-01-01

    More than 1100 debris flows were mobilized from shallow landslides during a rainstorm from 9 to 13 September 2013 in the Colorado Front Range, with the vast majority initiating on sparsely vegetated, south facing terrain. To investigate the physical processes responsible for the observed aspect control, we made measurements of soil properties on a densely forested north facing hillslope and a grassland-dominated south facing hillslope in the Colorado Front Range and performed numerical modeling of transient changes in soil pore water pressure throughout the rainstorm. Using the numerical model, we quantitatively assessed interactions among vegetation, rainfall interception, subsurface hydrology, and slope stability. Results suggest that apparent cohesion supplied by roots was responsible for the observed connection between debris flow initiation and slope aspect. Results suggest that future climate-driven modifications to forest structure could substantially influence landslide hazards throughout the Front Range and similar water-limited environments where vegetation communities may be more susceptible to small variations in climate.

  20. Identifying the initiating events of anti-Listeria responses using mice with conditional loss of IFNγ receptor subunit 1 (IFNGR1)

    PubMed Central

    Lee, Sang Hun; Carrero, Javier A.; Uppaluri, Ravindra; White, J. Michael; Archambault, Jessica M.; Lai, Koon Siew; Chan, Szeman Ruby; Sheehan, Kathleen C. F.; Unanue, Emil R.; Schreiber, Robert D.

    2013-01-01

    Whereas IFNγ is required for resolution of Listeria monocytogenes infection, the identities of the IFNγ responsive cells that initiate the process remain unclear. We addressed this question using novel mice with conditional loss of the IFNγ receptor (IFNGR1). Itgax-cre+Ifngr1f/f mice with selective IFNγ unresponsiveness in CD8α+ dendritic cells displayed increased susceptibility to infection. This phenotype was due to the inability of IFNγ unresponsive CD8α+ DCs to produce the initial burst of IL-12 induced by IFNγ from TNFα-activated NK/NKT cells. The defect in early IL-12 production resulted in increased IL-4 production that established a myeloid cell environment favoring Listeria growth. Neutralization of IL-4 restored Listeria resistance in Itgax-cre+Ifngr1f/f mice. We also found that Itgax-cre+Ifngr1f/f mice survived infection with low dose Listeria due to a second wave of IL-12 produced by Ly6Chi monocytes. Thus, an IFNγ-driven cascade involving CD8α+ DCs and NK/NKT cells induces the rapid production of IL-12 that initiates the anti-Listeria response. PMID:24048899

  1. Early events in xenograft development from the human embryonic stem cell line HS181--resemblance with an initial multiple epiblast formation.

    PubMed

    Gertow, Karin; Cedervall, Jessica; Jamil, Seema; Ali, Rouknuddin; Imreh, Marta P; Gulyas, Miklos; Sandstedt, Bengt; Ahrlund-Richter, Lars

    2011-01-01

    Xenografting is widely used for assessing in vivo pluripotency of human stem cell populations. Here, we report on early to late events in the development of mature experimental teratoma from a well-characterized human embryonic stem cell (HESC) line, HS181. The results show an embryonic process, increasingly chaotic. Active proliferation of the stem cell derived cellular progeny was detected already at day 5, and characterized by the appearance of multiple sites of engraftment, with structures of single or pseudostratified columnar epithelium surrounding small cavities. The striking histological resemblance to developing embryonic ectoderm, and the formation of epiblast-like structures was supported by the expression of the markers OCT4, NANOG, SSEA-4 and KLF4, but a lack of REX1. The early neural marker NESTIN was uniformly expressed, while markers linked to gastrulation, such as BMP-4, NODAL or BRACHYURY were not detected. Thus, observations on day 5 indicated differentiation comparable to the most early transient cell populations in human post implantation development. Confirming and expanding on previous findings from HS181 xenografts, these early events were followed by an increasingly chaotic development, incorporated in the formation of a benign teratoma with complex embryonic components. In the mature HS181 teratomas not all types of organs/tissues were detected, indicating a restricted differentiation, and a lack of adequate spatial developmental cues during the further teratoma formation. Uniquely, a kinetic alignment of rare complex structures was made to human embryos at diagnosed gestation stages, showing minor kinetic deviations between HS181 teratoma and the human counterpart.

  2. American National Standard: design basis for protection of light water nuclear power plants against effects of postulated pipe rupture

    SciTech Connect

    Not Available

    1980-12-31

    This standard addresses the design bases for light water reactor, nuclear power plant structures and components essential for the protection of public health and safety from the potential adverse effects of pipe whip, jet impingement, pressurization of compartments outside containment, environmental conditions and flooding associated with a postulated pipe rupture. The design bases for missile protection and the design bases for containment pressurization are not within this standard.

  3. Age influences initial dose and compliance to imatinib in chronic myeloid leukemia elderly patients but concomitant comorbidities appear to influence overall and event-free survival.

    PubMed

    Breccia, Massimo; Luciano, Luigiana; Latagliata, Roberto; Castagnetti, Fausto; Ferrero, Dario; Cavazzini, Francesco; Trawinska, Malgorzata Monica; Annunziata, Mario; Stagno, Fabio; Tiribelli, Mario; Binotto, Gianni; Crisà, Elena; Musto, Pellegrino; Gozzini, Antonella; Cavalli, Laura; Montefusco, Enrico; Iurlo, Alessandra; Russo, Sabina; Cedrone, Michele; Rossi, Antonella Russo; Pregno, Patrizia; Endri, Mauro; Spadea, Antonio; Molica, Matteo; Giglio, Gianfranco; Celesti, Francesca; Sorà, Federica; Storti, Sergio; D'Addosio, Ada; Cambrin, Giovanna Rege; Isidori, Alessandro; Sica, Simona; Abruzzese, Elisabetta; Speccha, Giorgina; Rosti, Gianantonio; Alimena, Giuliana

    2014-10-01

    We applied Charlson comorbidity index (CCI) stratification on a large cohort of chronic myeloid leukemia (CML) very elderly patients (>75 years) treated with imatinib, in order to observe the impact of concomitant diseases on both compliance and outcome. One hundred and eighty-one patients were recruited by 21 Italian centers. There were 95 males and 86 females, median age 78.6 years (range 75-93.6). According to Sokal score, 106 patients were classified as intermediate risk and 55 as high risk (not available in 20 patients). According to CCI stratification, 71 patients had score 0 and 110 a score ≥ 1. Imatinib standard dose was reduced at start of therapy (200-300 mg/day) in 68 patients independently from the evaluation of baseline comorbidities, but based only on physician judgement: 43.6% of these patients had score 0 compared to 34% of patients who had score ≥ 1. Significant differences were found in terms of subsequent dose reduction (39% of patients with score 0 compared to 53% of patients with score ≥ 1) and in terms of drug discontinuation due to toxicity (35% of patients with score 0 vs 65% of patients with score ≥ 1). We did not find significant differences as regards occurrence of hematologic side effects, probably as a consequence of the initial dose reduction: 39% of patients with score 0 experienced grade 3/4 hematologic toxicity (most commonly anemia) compared to 42% of patients with score ≥ 1. Independently from the initial dose, comorbidities again did not have an impact on development of grade 3/4 non-hematologic side effects (most commonly skin rash, muscle cramps and fluid retention): 62% of patients with score 0 compared to 52.5% of patients with score ≥ 1. Notwithstanding the reduced dose and the weight of comorbidities we did not find significant differences but only a trend in terms of efficacy: 66% of patients with score 0 achieved a CCyR compared to 54% of patients with score ≥ 1. Comorbidities appeared to have an impact on

  4. A Solution NMR Investigation into the Early Events of Amelogenin Nanosphere Self-Assembly Initiated with Sodium Chloride or Calcium Chloride

    SciTech Connect

    Buchko, Garry W.; Tarasevich, Barbara J.; Bekhazi, Jacky G.; Snead, Malcolm L.; Shaw, Wendy J.

    2008-12-08

    Using solution-state NMR spectroscopy, new insights into the early intermolecular interactions stabilizing amelogenin supramolecular assembly and the potential role of calcium ions have been discovered. Two-dimensional 1H-15N spectra were recorded for 15N-labeled amelogenin as a function of increasing Ca2+ concentration starting from monomeric conditions. Evidence for protein-protein interactions were observed between residues E18 and E40 in the N-terminus. At higher Ca2+ concentrations there was concurrent involvement of residues in both the N- (Y12-Q56) and the C-terminus (Q144-T171). Neither specific residues nor their stepwise interaction have previously been identified in the initial stages of nanosphere assembly.

  5. Dynamical response of multi-patch, flux-based models to the input of infected people: Epidemic response to initiated events

    NASA Astrophysics Data System (ADS)

    Rho, Young-Ah; Liebovitch, Larry S.; Schwartz, Ira B.

    2008-07-01

    The time course of an epidemic can be modeled using the differential equations that describe the spread of disease and by dividing people into “patches” of different sizes with the migration of people between these patches. We used these multi-patch, flux-based models to determine how the time course of infected and susceptible populations depends on the disease parameters, the geometry of the migrations between the patches, and the addition of infected people into a patch. We found that there are significantly longer lived transients and additional “ancillary” epidemics when the reproductive rate R is closer to 1, as would be typical of SARS (Severe Acute Respiratory Syndrome) and bird flu, than when R is closer to 10, as would be typical of measles. In addition we show, both analytical and numerical, how the time delay between the injection of infected people into a patch and the corresponding initial epidemic that it produces depends on R.

  6. miR-21 Might be Involved in Breast Cancer Promotion and Invasion Rather than in Initial Events of Breast Cancer Development.

    PubMed

    Petrović, Nina

    2016-04-01

    Breast cancer (BC) is a heterogeneous disease that develops into a large number of varied phenotypes. One of the features used in its classification and therapy selection is invasiveness. MicroRNA-21 (miR-21) is considered to be an important element of BC invasiveness, and miR-21 levels are frequently increased in different tumor types compared with normal tissue, including the breast. Experimental and literature research has highlighted that miR-21 was always significantly elevated in every study that included invasive breast carcinomas compared with healthy breast tissue. The main goal of this research was to specify the predominant role of miR-21 in the different phases of BC pathogenesis, i.e. whether it was involved in the early (initiation), later (promotion), or late (propagation, progression) phases. Our second goal was to explain the roles of miR-21 targets in BC by an in silico approach and literature review, and to associate the importance of miR-21 with particular phases of BC pathogenesis through the action of its target genes. Analysis has shown that changes in miR-21 levels might be important for the later and/or late phases of breast cancerogenesis rather than for the initial early phases. Targets of miR-21 (TIMP3, PDCD4, PTEN, TPM1 and RECK) are also primarily involved in BC promotion and progression, especially invasion, angiogenesis and metastasis. miR-21 expression levels could perhaps be used in conjunction with the standard diagnostic parameters as an indicator of BC presence, and to indicate a phenotype likely to show early invasion/metastasis detection and poor prognosis.

  7. The role of high-energy events (hurricanes and/or tsunamis) in the sedimentation, diagenesis and karst initiation of tropical shallow water carbonate platforms and atolls

    NASA Astrophysics Data System (ADS)

    Bourrouilh-Le Jan, F. G.

    1998-06-01

    Karst morphology appears early, even during carbonate sediment deposition. Examples from modern to 125-ka-old sub-, inter- and supratidal sediments are given from the Bahamas (Atlantic Ocean) and from Tuamotuan atolls (southeastern Pacific Ocean), with mineralogical and hydrological analyses. Karstification is favoured by the aragonitic composition of bioclasts coming from the shallow marine bio-factory. Lithification by aragonite cements appears as a rim around carbonate deposits and dissolution and non-cementation start at the same time on modern supratidal deposits (Andros micrite or atoll coral rudite) and provoke the formation of a central depression on small or large carbonate platforms. In fact, this early solution of the centre of platforms is closely related to the location of each of the studied examples on hurricane tracks. High-energy events, such as hurricanes and tsunamis, affect sediment transport but hurricanes also affect diagenesis as a result of the enormous volume of freshwater carried and discharged along their paths. This couple, lithification-solution, is localised at sea level and accompanies sea-level fluctuations along the eustatic curve. Because of the precise location of hurricane action all around the Earth, early karstification by aragonite solution, cementation and supratidal carbonate sediment accumulations (high-energy trails) act together on all the platforms and atolls located inside the Tropics (23°27') between roughly 5°-10° and 25° on both hemispheres. However, early karstification acts alone on shallow carbonate platforms including atolls along the equatorial belt between 5°-10°N and 5°-10°S. These early steps of karstification are linked to the ocean-atmosphere interface due to the bathymetrical position of shallow carbonate platforms, including atolls. They lead to complex karstified emerged platforms, called high carbonate islands, where carbonate diagenesis, together with the development of bauxite- and/or a

  8. Numerical simulation of an initial tsunami waveform based on sea-level data inversion: case study for the Shicotan event of the 4th October 1994

    NASA Astrophysics Data System (ADS)

    Voronina, T.

    2012-04-01

    The recent disaster of Japanese tsunami in March 2011, which caused nearly 16,000 deaths and estimated at US35-billion to US40-billion the insured cost, served as a last wake-up call to world community. Since then, the development of technology of an early warning system including methods for forecasting in real-time the tsunami waves propagation has provided a way to mitigate the adverse impacts of future tsunamis. The development of tsunami simulation models makes it possible to identify regions at tsunami risk. One of the most important issues of the tsunami modeling is gaining some insight of a tsunami source - the case in hand is the tsunami wave generated by the sea surface deformation. The latter is presumed to be equal to the co-seismic vertical displacement of the sea floor. This paper proposes an approach to recover initial tsunami waveform in tsunami source area based on the inversion of remote measurements of sea-level data. This inverse problem is treated as an ill-posed problem of hydrodynamic inversion with tsunami tide gauge records. Tsunami wave propagation is considered within the scope of the linear shallow-water theory. The direct problem is approximated by a finite-difference technique. The ill-posed inverse problem of recovering initial tsunami waveform is regularized by means of a least square inversion using the truncated SVD approach. The numerical simulating yields the so-called r-solution. The algorithm is verified with bathymetry data of the Sea of Okhotsk, synthetic and real records. In this paper, we make an attempt to answer the following questions: (1) How accurately can a tsunami source be recovered using recordings at a given tide gauge network? (2) Is it possible to improve the quality of recovering a tsunami source by distinguishing the "most informative" part of the given observation system? For answering these questions, we have carried out a series of numerical experiments. Based on the characteristics of a given tide gauges

  9. Eukaryotic Translation Initiation Factor 4E Is a Feed-Forward Translational Coactivator of Transforming Growth Factor β Early Protransforming Events in Breast Epithelial Cells

    PubMed Central

    Decarlo, Lindsey; Mestel, Celine; Barcellos-Hoff, Mary-Helen

    2015-01-01

    Eukaryotic translation initiation factor 4E (eIF4E) is overexpressed early in breast cancers in association with disease progression and reduced survival. Much remains to be understood regarding the role of eIF4E in human cancer. We determined, using immortalized human breast epithelial cells, that elevated expression of eIF4E translationally activates the transforming growth factor β (TGF-β) pathway, promoting cell invasion, a loss of cell polarity, increased cell survival, and other hallmarks of early neoplasia. Overexpression of eIF4E is shown to facilitate the selective translation of integrin β1 mRNA, which drives the translationally controlled assembly of a TGF-β receptor signaling complex containing α3β1 integrins, β-catenin, TGF-β receptor I, E-cadherin, and phosphorylated Smad2/3. This receptor complex acutely sensitizes nonmalignant breast epithelial cells to activation by typically substimulatory levels of activated TGF-β. TGF-β can promote cellular differentiation or invasion and transformation. As a translational coactivator of TGF-β, eIF4E confers selective mRNA translation, reprogramming nonmalignant cells to an invasive phenotype by reducing the set point for stimulation by activated TGF-β. Overexpression of eIF4E may be a proinvasive facilitator of TGF-β activity. PMID:25986608

  10. A Postulated Planetary Collision, the Terrestrial Planets, the Moon and Smaller Solar-System Bodies

    NASA Astrophysics Data System (ADS)

    Woolfson, M. M.

    2013-11-01

    In a scenario produced by the Capture Theory of planetary formation, a collision between erstwhile solar-system giant planets, of masses 798.75 and 598.37 M ⊕, is simulated using smoothed-particle hydrodynamics. Due to grain-surface chemistry that takes place in star-forming clouds, molecular species containing hydrogen, with a high D/H ratio taken as 0.01, form a layer around each planetary core. Temperatures generated by the collision initiate D-D reactions in these layers that, in their turn, trigger a reaction chain involving heavier elements. The nuclear explosion shatters and disperses both planets, leaving iron-plus-silicate stable residues identified as a proto-Venus and proto-Earth. A satellite of one of the colliding planets, captured or retained by the proto-Earth core, gave the Moon; two massive satellites released into heliocentric orbits became Mercury and Mars. For the Moon and Mars, abrasion of their surfaces exposed to collision debris results in hemispherical asymmetry. Mercury, having lost a large part of its mantle due to massive abrasion, reformed to give the present high-density body. Debris from the collision gave rise to asteroids and comets, much of the latter forming an inner reservoir stretching outwards from the inner Kuiper Belt that replenishes the Oort Cloud when it is depleted by a severe perturbation. Other features resulting from the outcome of the planetary collision are the relationship of Pluto and Triton to Neptune, the presence of dwarf planets and light-atom isotopic anomalies in meteorites.

  11. Associations of Inflammatory Markers with AIDS and non-AIDS Clinical Events after Initiation of Antiretroviral Therapy: AIDS Clinical Trials Group A5224s, a substudy of ACTG A5202

    PubMed Central

    McComsey, Grace A; Kitch, Douglas; Sax, Paul E; Tierney, Camlin; Jahed, Nasreen C; Melbourne, Kathleen; Ha, Belinda; Brown, Todd T; Bloom, Anthony; Fedarko, Neal; Daar, Eric S

    2013-01-01

    Background The association of inflammatory biomarkers with clinical events after antiretroviral therapy (ART) initiation is unclear. Methods A5202 randomized 1857 treatment-naive subjects to abacavir/lamivudine or tenofovir-DF/emtricitabine with efavirenz or atazanavir/ritonavir. Substudy A5224s measured inflammatory biomarkers on subjects with available plasma from baseline and weeks 24 or 96. An exploratory analysis of the association of hsCRP, IL-6, sTNF-RI, sTNF-RII, TNF-α, sVCAM-1, and sICAM-1 with times to AIDS and to non-AIDS events used Cox proportional hazards models. Results Analysis included 244 subjects; 85% male, 48% white non-Hispanic, with median age 39 years, HIV-1 RNA 4.6 log10 copies/mL, and CD4 240 cells/μL. Overall, 13 AIDS events (9 opportunistic infections; 3 AIDS-cancers, 1 recurrent bacterial pneumonia) and 18 non-AIDS events (6 diabetes, 4 cancers, 3 cardiovascular, 5 pneumonias) occurred. Higher baseline IL-6, sTNF-RI, sTNF-RII, and sICAM-1 were significantly associated with increased risk of AIDS-defining events. Adjustment for baseline HIV-1 RNA did not change results, while adjusting for baseline CD4 count left only sTNF-RI and sICAM-1 significantly associated with increased risk. Time-updated values of IL-6, sTNFR-I and II, and sICAM-1 were also associated with an increased risk. For non-AIDS events, only higher baseline hsCRP was significantly associated with increased risk, while higher IL-6 was marginally associated with higher risk. Analyses of time-updated biomarker values showed TNF-α to be significantly associated with increased risk, even after adjustment for ART, and CD4 count or HIV-1 RNA. Conclusion Higher levels of several inflammatory biomarkers were independently associated with increased risk of AIDS and non-AIDS events. PMID:24121755

  12. Probabilities of Natural Events Occurring at Savannah River Plant

    SciTech Connect

    Huang, J.C.

    2001-07-17

    This report documents the comprehensive evaluation of probability models of natural events which are applicable to Savannah River Plant. The probability curves selected for these natural events are recommended to be used by all SRP/SRL safety analysts. This will ensure a consistency in analysis methodology for postulated SAR incidents involving natural phenomena.

  13. Environmental consequences of postulated plutonium releases from Exxon Nuclear MOFP, Richland, Washington, as a result of severe natural phenomena

    SciTech Connect

    Jamison, J.D.; Watson, E.C.

    1980-02-01

    Potential environmental consequences in terms of radiation dose to people are presented for postulated plutonium releases caused by severe natural phenomena at the Exxon Nuclear Company Mixed Oxide Fabrication Plant (MOFP), Richland, Washington. The severe natural phenomena considered are earthquakes, tornadoes, high straight-line winds, and floods. Maximum plutonium deposition values are given for significant locations around the site. All important potential exposure pathways are examined. The most likely 50-year committed dose equivalents are given for the maximum-exposed individual and the population within a 50-mile radius of the plant. The maximum plutonium deposition values most likely to occur offsite are also given.

  14. Potential health risks from postulated accidents involving the Pu-238 RTG on the Ulysses solar exploration mission

    NASA Technical Reports Server (NTRS)

    Goldman, Marvin; Hoover, Mark D.; Nelson, Robert C.; Templeton, William; Bollinger, Lance; Anspaugh, Lynn

    1991-01-01

    Potential radiation impacts from launch of the Ulysses solar exploration experiment were evaluated using eight postulated accident scenarios. Lifetime individual dose estimates rarely exceeded 1 mrem. Most of the potential health effects would come from inhalation exposures immediately after an accident, rather than from ingestion of contaminated food or water, or from inhalation of resuspended plutonium from contaminated ground. For local Florida accidents (that is, during the first minute after launch), an average source term accident was estimated to cause a total added cancer risk of up to 0.2 deaths. For accidents at later time after launch, a worldwide cancer risk of up to three cases was calculated (with a four in a million probability). Upper bound estimates were calculated to be about 10 times higher.

  15. Comparative Reaction Diagrams for the SN2 Reaction Formulated According to the Leffler Analysis and the Hammond Postulate.

    PubMed

    Haddon, Robert C; Tian, Ziqi; Jiang, De-En

    2016-05-06

    The Hammond Postulate and the Leffler analysis have provided a cornerstone in the understanding of reaction processes in organic chemistry for over 60 years, yet quantitative applications of these methodologies over the range of reactions envisaged in the original works remain elusive. In the present paper, we analyze a series of SN2 reactions in three solvents that lead to endothermic and exothermic reaction processes, and we show that within the hybridization reaction coordinate the SN2 reaction is fully consistent with both treatments. We give new presentations of the reaction energies as a function of reaction progress, which allow the generation of unified reaction coordinate diagrams that show a linear relationship between the hybridization metric of reaction progress and the relative energies of the stationary points on the potential surface as a function of structure and solvent as originally envisaged by Leffler and Hammond.

  16. Potential health risks from postulated accidents involving the Pu-238 RTG (radioisotope thermoelectric generator) on the Ulysses solar exploration mission

    SciTech Connect

    Goldman, M. ); Nelson, R.C. ); Bollinger, L. ); Hoover, M.D. . Inhalation Toxicology Research Inst.); Templeton, W. ); Anspaugh, L. (Lawren

    1990-11-02

    Potential radiation impacts from launch of the Ulysses solar exploration experiment were evaluated using eight postulated accident scenarios. Lifetime individual dose estimates rarely exceeded 1 mrem. Most of the potential health effects would come from inhalation exposures immediately after an accident, rather than from ingestion of contaminated food or water, or from inhalation of resuspended plutonium from contaminated ground. For local Florida accidents (that is, during the first minute after launch), an average source term accident was estimated to cause a total added cancer risk of up to 0.2 deaths. For accidents at later times after launch, a worldwide cancer risk of up to three cases was calculated (with a four in a million probability). Upper bound estimates were calculated to be about 10 times higher. 83 refs.

  17. EventSlider User Manual

    DTIC Science & Technology

    2016-09-01

    FrameworkElement parent class), which allows for efficient batch setting of these main properties without changing the display until the initialization is...a single click, or a tap, near or on an event line. 4. Library and Namespace The EventSlider control has been compiled into the following dynamic...namespace:WPFControls.EventSlider;assembly=WPFControls.EventSlider" Only a single class is exposed in this namespace, the EventSlider class. All methods, properties, and

  18. The role of von Neumann and Lueders postulates in the Einstein, Podolsky, and Rosen considerations: Comparing measurements with degenerate and nondegenerate spectra

    SciTech Connect

    Khrennikov, Andrei

    2008-05-15

    We show that the projection postulate plays a crucial role in the discussion on the so-called quantum nonlocality, in particular, in the Einstein, Podolsky, and Rosen argument. We stress that the original von Neumann projection postulate was crucially modified by extending it to observables with degenerate spectra (the Lueders postulate) and we show that this modification is highly questionable from a physical point of view and is the real source of quantum nonlocality. The use of the original von Neumann postulate eliminates this problem: instead of an action at a distance nonlocality we obtain a classical measurement nonlocality, which is related to the synchronization of two measurements (on the two parts of a composite system)

  19. An Ambiguous Statement Called the "tetrad Postulate" and the Correct Field Equations Satisfied by the Tetrad Fields

    NASA Astrophysics Data System (ADS)

    Rodrigues, Waldyr A.; Souza, Quintino A. G.

    The names tetrad, tetrads, cotetrads have been used with many different meanings in the physics literature, not all of them equivalent from the mathematical point of view. In this paper, we introduce unambiguous definitions for each of those terms, and show how the old miscellanea made many authors introduce in their formalism an ambiguous statement called the "tetrad postulate," which has been the source of much misunderstanding, as we show explicitly by examining examples found in the literature. Since formulating Einstein's field equations intrinsically in terms of cotetrad fields θa, a = 0, 1, 2, 3 is a worthy enterprise, we derive the equation of motion of each θa using modern mathematical tools (the Clifford bundle formalism and the theory of the square of the Dirac operator). Indeed, we identify (giving all details and theorems) from the square of the Dirac operator some noticeable mathematical objects, namely, the Ricci, Einstein, covariant D'Alembertian and the Hodge Laplacian operators, which permit us to show that each θa satisfies a well-defined wave equation. Also, we present for completeness a detailed derivation of the cotetrad wave equations from a variational principle. We compare the cotetrad wave equation satisfied by each θa with some others appearing in the literature, and which are unfortunately in error.

  20. Unique cellular events occurring during the initial interaction of macrophages with matrix-retained or methylated aggregated low density lipoprotein (LDL). Prolonged cell-surface contact during which ldl-cholesteryl ester hydrolysis exceeds ldl protein degradation.

    PubMed

    Buton, X; Mamdouh, Z; Ghosh, R; Du, H; Kuriakose, G; Beatini, N; Grabowski, G A; Maxfield, F R; Tabas, I

    1999-11-05

    A critical event in atherogenesis is the interaction of arterial wall macrophages with subendothelial lipoproteins. Although most studies have investigated this interaction by incubating cultured macrophages with monomeric lipoproteins dissolved in media, arterial wall macrophages encounter lipoproteins that are mostly bound to subendothelial extracellular matrix, and these lipoproteins are often aggregated or fused. Herein, we utilize a specialized cell-culture system to study the initial interaction of macrophages with aggregated low density lipoprotein (LDL) bound to extracellular matrix. The aggregated LDL remains extracellular for a relatively prolonged period of time and becomes lodged in invaginations in the surface of the macrophages. As expected, the degradation of the protein moiety of the LDL was very slow. Remarkably, however, hydrolysis of the cholesteryl ester (CE) moiety of the LDL was 3-7-fold higher than that of the protein moiety, in stark contrast to the situation with receptor-mediated endocytosis of acetyl-LDL. Similar results were obtained using another experimental system in which the degradation of aggregated LDL protein was delayed by LDL methylation rather than by retention on matrix. Additional experiments indicated the following properties of this interaction: (a) LDL-CE hydrolysis is catalyzed by lysosomal acid lipase; (b) neither scavenger receptors nor the LDL receptor appear necessary for the excess LDL-CE hydrolysis; and (c) LDL-CE hydrolysis in this system is resistant to cellular potassium depletion, which further distinguishes this process from receptor-mediated endocytosis. In summary, experimental systems specifically designed to mimic the in vivo interaction of arterial wall macrophages with subendothelial lipoproteins have demonstrated an initial period of prolonged cell-surface contact in which CE hydrolysis exceeds protein degradation.

  1. Observations and Modeling of Composition of Upper Troposphere/Lower Stratosphere (UTILS): Isentropic Mixing Events and Morphology of HNO3 as Observed by HIRDLS and Comparison with Results from Global Modeling Initiative

    NASA Technical Reports Server (NTRS)

    Rodriquez, J. M.; Douglass, A.R.; Yoshida, Y.; Strahan, S.; Duncan, B.; Olsen, M.; Gille, J.; Yudin, V.; Nardi, B.

    2008-01-01

    isentropic exchange of air masses between the tropical upper troposphere and mid-latitude lowermost stratosphere (the so-called "middle world") is an important pathway for stratospheric-tropospheric exchange. A seasonal, global view of this process has been difficult to obtain, in part due to the lack of the vertical resolution in satellite observations needed to capture the laminar character of these events. Ozone observations at a resolution of about 1 km from the High Resolution Dynamic Limb Sounder (HIRDLS) on NASA's Aura satellite show instances of these intrusions. Such intrusions should also be observable in HN03 observations; however, the abundances of nitric acid could be additionally controlled by chemical processes or incorporation and removal into ice clouds. We present a systematic examination of the HIRDLS data on O3 and HNO3 to determine the seasonal and spatial characteristics of the distribution of isentropic intrusions. At the same time, we compare the observed distributions with those calculated by the Global Modeling Initiative combined tropospheric-stratospheric model, which has a vertical resolution of about I km. This Chemical Transport Model (CTM) is driven by meteorological fields obtained from the GEOS-4 system of NASA/Goddard Global Modeling and Assimilation Office (GMAO), for the Aura time period, at a vertical resolution of about 1 km. Such comparison brings out the successes and limitations of the model in representing isentropic stratospheric-tropospheric exchange, and the different processes controlling HNO3 in the UTAS.

  2. The postulations á la D’Alembert and á la Cauchy for higher gradient continuum theories are equivalent: a review of existing results

    PubMed Central

    Seppecher, P.

    2015-01-01

    In order to found continuum mechanics, two different postulations have been used. The first, introduced by Lagrange and Piola, starts by postulating how the work expended by internal interactions in a body depends on the virtual velocity field and its gradients. Then, by using the divergence theorem, a representation theorem is found for the volume and contact interactions which can be exerted at the boundary of the considered body. This method assumes an a priori notion of internal work, regards stress tensors as dual of virtual displacements and their gradients, deduces the concept of contact interactions and produces their representation in terms of stresses using integration by parts. The second method, conceived by Cauchy and based on the celebrated tetrahedron argument, starts by postulating the type of contact interactions which can be exerted on the boundary of every (suitably) regular part of a body. Then it proceeds by proving the existence of stress tensors from a balance-type postulate. In this paper, we review some relevant literature on the subject, discussing how the two postulations can be reconciled in the case of higher gradient theories. Finally, we underline the importance of the concept of contact surface, edge and wedge s-order forces. PMID:26730215

  3. Event Perception.

    PubMed

    Radvansky, Gabriel; Zacks, Jeffrey M

    2011-11-01

    Events are central elements of human experience. Formally, they can be individuated in terms of the entities that compose them, the features of those entities, and the relations amongst entities. Psychologically, representations of events capture their spatiotemporal location, the people and objects involved, and the relations between these elements. Here, we present an account of the nature of psychological representations of events and how they are constructed and updated. Event representations are like images in that they are isomorphic to the situations they represent. However, they are like models or language in that they are constructed of components rather than being holistic. Also, they are partial representations that leave out some elements and abstract others. Representations of individual events are informed by schematic knowledge about general classes of events. Event representations are constructed in a process that segments continuous activity into discrete events. The construction of a series of event representations forms a basis for predicting the future, planning for that future, and imagining alternatives.

  4. Event Perception

    PubMed Central

    Radvansky, Gabriel; Zacks, Jeffrey M.

    2012-01-01

    Events are central elements of human experience. Formally, they can be individuated in terms of the entities that compose them, the features of those entities, and the relations amongst entities. Psychologically, representations of events capture their spatiotemporal location, the people and objects involved, and the relations between these elements. Here, we present an account of the nature of psychological representations of events and how they are constructed and updated. Event representations are like images in that they are isomorphic to the situations they represent. However, they are like models or language in that they are constructed of components rather than being holistic. Also, they are partial representations that leave out some elements and abstract others. Representations of individual events are informed by schematic knowledge about general classes of events. Event representations are constructed in a process that segments continuous activity into discrete events. The construction of a series of event representations forms a basis for predicting the future, planning for that future, and imagining alternatives. PMID:23082236

  5. Ex Vivo and In Vivo Mice Models to Study Blastocystis spp. Adhesion, Colonization and Pathology: Closer to Proving Koch's Postulates

    PubMed Central

    Ajjampur, Sitara S. R.; Png, Chin Wen; Chia, Wan Ni; Zhang, Yongliang; Tan, Kevin S. W.

    2016-01-01

    Blastocystis spp. are widely prevalent extra cellular, non-motile anerobic protists that inhabit the gastrointestinal tract. Although Blastocystis spp. have been associated with gastrointestinal symptoms, irritable bowel syndrome and urticaria, their clinical significance has remained controversial. We established an ex vivo mouse explant model to characterize adhesion in the context of tissue architecture and presence of the mucin layer. Using confocal microscopy with tissue whole mounts and two axenic isolates of Blastocystis spp., subtype 7 with notable differences in adhesion to intestinal epithelial cells (IEC), isolate B (ST7-B) and isolate H (more adhesive, ST7-H), we showed that adhesion is both isolate dependent and tissue trophic. The more adhesive isolate, ST7-H was found to bind preferentially to the colon tissue than caecum and terminal ileum. Both isolates were also found to have mucinolytic effects. We then adapted a DSS colitis mouse model as a susceptible model to study colonization and acute infection by intra-caecal inoculation of trophic Blastocystis spp.cells. We found that the more adhesive isolate ST7-H was also a better colonizer with more mice shedding parasites and for a longer duration than ST7-B. Adhesion and colonization was also associated with increased virulence as ST7-H infected mice showed greater tissue damage than ST7-B. Both the ex vivo and in vivo models used in this study showed that Blastocystis spp. remain luminal and predominantly associated with mucin. This was further confirmed using colonic loop experiments. We were also successfully able to re-infect a second batch of mice with ST7-H isolates obtained from fecal cultures and demonstrated similar histopathological findings and tissue damage thereby coming closer to proving Koch’s postulates for this parasite. PMID:27508942

  6. Initial Results on Soil Moisture in Relation to Timing of Snowpack, Temperature, and Heavy Vs. Moderate Rain Events from a New Soil Monitoring Network in the Southern Rocky Mountains

    NASA Astrophysics Data System (ADS)

    Osenga, E. C.; Schnissel, J.; Katzenberger, J.

    2014-12-01

    The Roaring Fork Valley (RFV) in the Rocky Mountains of Colorado is comprised of a diversity of ecosystems occurring within a single watershed. From one end of the valley to the other, the landscape undergoes an over 1500m gain in elevation, creating a unique opportunity for comparison of conditions in different habitats of close geographic proximity. Interested in comparing the ecological responses of these different habitats in the context of rising global temperatures, the Aspen Global Change Institute (AGCI) partnered with City of Aspen, Pitkin Country Open Space and Trails, and the Aspen Center for Environmental Studies to install soil monitoring stations at multiple elevations within the watershed. Soil moisture was identified as the primary indicator for monitoring because there is a dearth of local soil moisture data, and soil moisture plays a vital role in plant survival and correlates closely with precipitation and air temperature. Additionally, as precipitation regimes shift in the future, there is a need to better understand the interplay between vegetative water availability during the critical early growing season and timing, areal extent, and depth of snowpack. Two initial soil monitoring stations were installed in undeveloped, montane ecosystems of the Roaring Fork Watershed in 2012. Each station measures air temperature; relative humidity; rainfall; and soil moisture at 5, 20, and 52 cm depths. Two additional soil monitoring stations are being established over the summer of 2014, and additional stations within the Roaring Fork soil moisture network are planned for future years. Early data from the existing sites indicate the importance of timing of snowmelt in maintaining soil moisture through the early dry months of summer and dissimilarity between the impact of moderate and heavy rain events on soil moisture at different depths. These data have implications for restoration, management, and planning for local ecosystems and have significance for

  7. The body has a brake: micrin is a postulated new gonadal hormone curbing tissue overgrowth and restricting reproduction.

    PubMed

    Hart, John E

    2014-12-01

    There is evidence for an unrecognised classical hormone secreted by the mammalian gonad. This postulated hormone--'micrin' (pronounced 'my-crin')--represents the body's brake against tissue overgrowth. When oestrogens are administered in high doses to female rats there is a considerable (non-artefactual) increase in the relative size and weight of organs such as the pituitary, adrenals, uterus and liver--suggesting an organotrophic (organ-building) role for endogenous oestrogens. This effect is exaggerated if the animals are first ovariectomized, indicating the removal of a negative ovarian factor, micrin. These organ enlargements can be reduced by pretreating the rats with large doses of antioestrogens such as clomiphene and tamoxifen. This antiestrogenic blockade of exogenous oestrogens is itself blunted by prior removal of the ovaries. It is proposed that antioestrogens (e.g. tamoxifen in breast cancer treatment) antagonize the organotrophic effects of oestrogens by competing for the oestrogen receptor peripherally and centrally and via an increase in the secretion of ovarian micrin. It is deduced that micrin is the testicular 'inhibin' proposed in the 1930s, not the molecule that now bears that name, which acts at the pituitary tier as a downregulator of follicle-stimulating hormone. The hallmark of micrin deficiency in the male rat is a pituitary hypertrophy that follows castration. This is reversible with a steroid-depleted aqueous bovine testicular extract, the micrin within which suppresses the hypothalamus, normalizing the pituitary. Micrin probably acts as a brake on peripheral tissues directly but also indirectly at the meta-level via the hypothalamic-pituitary axis, resetting a hypothalamic 'organostat' controlling organ and tissue masses, part of the 'organotrophic system' of internal size regulation. Besides endocrine (circulating) micrin from the gonads there is probably paracrine (locally acting) micrin produced in the brain. This is involved in a

  8. Event Shape Sorting: selecting events with similar evolution

    NASA Astrophysics Data System (ADS)

    Tomášik, Boris; Kopečná, Renata

    2017-03-01

    We present novel method for the organisation of events. The method is based on comparing event-by-event histograms of a chosen quantity Q that is measured for each particle in every event. The events are organised in such a way that those with similar shape of the Q-histograms end-up placed close to each other. We apply the method on histograms of azimuthal angle of the produced hadrons in ultrarelativsitic nuclear collisions. By selecting events with similar azimuthal shape of their hadron distribution one chooses events which are likely that they underwent similar evolution from the initial state to the freeze-out. Such events can more easily be compared to theoretical simulations where all conditions can be controlled. We illustrate the method on data simulated by the AMPT model.

  9. EVENT SEGMENTATION

    PubMed Central

    Zacks, Jeffrey M.; Swallow, Khena M.

    2012-01-01

    One way to understand something is to break it up into parts. New research indicates that segmenting ongoing activity into meaningful events is a core component of ongoing perception, with consequences for memory and learning. Behavioral and neuroimaging data suggest that event segmentation is automatic and that people spontaneously segment activity into hierarchically organized parts and sub-parts. This segmentation depends on the bottom-up processing of sensory features such as movement, and on the top-down processing of conceptual features such as actors’ goals. How people segment activity affects what they remember later; as a result, those who identify appropriate event boundaries during perception tend to remember more and learn more proficiently. PMID:22468032

  10. Transformational Events

    ERIC Educational Resources Information Center

    Denning, Peter J.; Hiles, John E.

    2006-01-01

    Transformational Events is a new pedagogic pattern that explains how innovations (and other transformations) happened. The pattern is three temporal stages: an interval of increasingly unsatisfactory ad hoc solutions to a persistent problem (the "mess"), an offer of an invention or of a new way of thinking, and a period of widespread adoption and…

  11. Complex Event Recognition Architecture

    NASA Technical Reports Server (NTRS)

    Fitzgerald, William A.; Firby, R. James

    2009-01-01

    Complex Event Recognition Architecture (CERA) is the name of a computational architecture, and software that implements the architecture, for recognizing complex event patterns that may be spread across multiple streams of input data. One of the main components of CERA is an intuitive event pattern language that simplifies what would otherwise be the complex, difficult tasks of creating logical descriptions of combinations of temporal events and defining rules for combining information from different sources over time. In this language, recognition patterns are defined in simple, declarative statements that combine point events from given input streams with those from other streams, using conjunction, disjunction, and negation. Patterns can be built on one another recursively to describe very rich, temporally extended combinations of events. Thereafter, a run-time matching algorithm in CERA efficiently matches these patterns against input data and signals when patterns are recognized. CERA can be used to monitor complex systems and to signal operators or initiate corrective actions when anomalous conditions are recognized. CERA can be run as a stand-alone monitoring system, or it can be integrated into a larger system to automatically trigger responses to changing environments or problematic situations.

  12. Estimated subsidence in the Chino-Riverside and Bunker Hill-Yucaipa areas in Southern California for a postulated water-level lowering, 1965-2015

    USGS Publications Warehouse

    Lofgren, Ben Elder

    1971-01-01

    One of the alternate plans for water utilization being considered by the California Department of Water Resources in the Chino-Riverside and Bunker Hill-Yucaipa areas in southern California involves partial mining of ground water during the period 1965-2015, and consequent substantial lowering of water levels. The Department wants to know whether land subsidence would be a problem as a result of the postulated lowering. To answer this question, to the extent that leveling control permits, the present study has been made at the request of and in cooperation with the State of California.At a few locations in the Chino-Riverside and Bunker Hill-Yucaipa areas, comparable water-level decline and subsidence data are available from which rough estimates can be made of subsidence that would occur as a result of the postulated lowering from 1965 to 2015. Limited leveling control, and apparent discrepancies in the data, preclude accurate determination of amounts of subsidence caused by historic water-level decline.Based on 1965-2015 water-level changes postulated by the California Department of Water Resources and on available subsidence/head decline ratios, as much as 6 feet of subsidence might occur northeast of the San Jacinto fault between Loma Linda and San Bernardino, in an area of more than 350 feet of projected water-level decline. Also, as much as 1.5 feet of subsidence might occur in the vicinity of Ontario.

  13. Rare Events

    DTIC Science & Technology

    2009-10-01

    terrorists are likely to acquire and use WMDs over the next ten years. • Provide means to target areas, entities and persons facilitating adver - sary WMD...complicated and unpredictable to begin with, but also that human adver - saries (unlike physical disasters) will react and adapt to our planning to try to make...virulent vaccine strain (Keim et al., 2001). The latter might not be regarded as a bioterrorism event, even though it caused seven deaths and incited

  14. Childhood leukemia genetic bottleneck phenomenon related to TEL-AML1: the postulation by a mathematical model.

    PubMed

    Ivanovski, Petar; Ivanovski, Ivan; Nikolić, Dimitrije; Jovanović, Ivana

    2012-03-01

    Childhood leukemia bottleneck phenomenon is the most mysterious corollary of the prenatal origin discovery of leukemogenic chromosome translocations. The bottleneck is evidence that leukemia initiation, by in utero acquired chromosome translocations that generate functional fusion genes, is far more common than the incidence rate of corresponding leukemia. For childhood TEL-AML1(+) acute lymphoblastic leukemia (ALL) this equates to approximately 100 times. Practically this means that among a hundred children born with TEL-AML1 fusion gene, only one child will later in its life develop ALL. The key data necessary for unraveling of this mystery were discovered in 2002. It was the level of TEL-AML1(+) cells’ frequency. The bottleneck is caused by the very low body TEL-AML1(+) cell count. Only one out of a thousand B cells carries TEL-AML1 fusion gene. TEL-AML1(+) body cell count is low because TEL-AML1 fusion is generated at cell level of 10(-3) to 10(-4) just during the late fetal lymphopoiesis i.e. after the 36th gestational week.

  15. Mysterious Decomposition of Alkoxyphosphonium Chlorides: Postulated Involvement of the HCl2 Anion and Its Capture in the Solid State.

    PubMed

    Nikitin, Kirill; Müller-Bunz, Helge; Muldoon, Jimmy; Gilheany, Declan G

    2017-04-06

    P-Alkoxyphosphonium (AP) chlorides were generated by reacting P-chlorophosphonium chlorides with alcohols. Their well-known spontaneous Arbuzov-type collapse leading to phosphine oxides was studied and its rate found to be dependent on a number of factors in an unexpected fashion: it is inversely proportional to the initial concentration and it shows strong dependence on the acidity of the media but is not very sensitive to the presence of base. To explain these observations, we evoke a self-inhibition model with the formation of the less nucleophilic hydrodichloride anion HCl2 in solution. Detailed analysis of the kinetic data yields the association constant (K=3×10(2)  m(-1) ) of the putative HCl2 species in chloroform. Experimental observations for the collapse of highly enriched diastereomeric alkoxyphosphonium (DAP) chlorides are fully analogous to the achiral AP also implying the involvement of HCl2 anions. Moreover, crystallisation of a highly enriched DAP salt derived from (-)-menthol furnished, for the first time, crystals of individual (RP )-DAP hydrodichloride as confirmed by X-ray diffractometry. Importantly, the P-configuration and detailed conformation of the DAP moiety is in good agreement with DFT-level computational results. The thermal collapse of (RP )-DAP⋅HCl2 proceeds with complete retention of the P-configuration furnishing the phosphine oxide of exceptional enantiomeric purity.

  16. Postulating that our neurological models for musculoskeletal support, movement, and emotional expression come from archetypal forms in early organisms.

    PubMed

    Appleton, John A

    2006-01-01

    The ability for humans, in principle, to almost effortlessly support themselves against gravity, to move with grace, and to express themselves in subtle and beautiful ways is amazing, given the number of moveable joints, variety of obstacles and intentions, and possible emotions to express. The actual mechanics are obviously astonishing but the models for these activities, in origin, must be simple. The basic hypotheses concerning these models are the following: The neurological model for the control of our musculoskeletal system is a simple support system from early organisms. This model involves a complementary relationship between the dorsal and ventral surfaces. There are three functionally distinct parts of the body, though not visually observable. These parts, named here "the director, motor, and rudder segments," are functionally distinct in optimal posture and movement. Healthy balance, posture, and movement result from their relatively independent yet coordinated actions. Forms of locomotion used by early organisms: peristalsis, lateral undulation, and dorsal-ventral undulation are present in us yet. Four frozen phases of the dorsal-ventral wave, for example, constitute four distinct postural and personality styles. I present these hypotheses together in this short paper as an introduction to a new illustration-dependent way to conceive some of our psychophysical realities. The hypotheses came from efforts to develop mental imagery to assist students in learning the Alexander technique (AT). In addition, a little known theory concerning four basic emotions and personality types, called the Fusion Theory, provided an initial concept of personality types. Four fixed postural patterns that I observed in teaching AT linked well to this personality typology. There is research that supports the use of mental imagery to affect change in body use, mostly in the sports and dance fields, but none exists addressing the specific imagery derived from these hypotheses

  17. Reactivity initiated accident test series Test RIA 1-4

    SciTech Connect

    Martinson, Z.R.; El-Genk, M.S.; Fukuda, S.K.; LaPointe, R.E.; Osetek, D.J.

    1980-05-01

    The Reactivity Initiated Accident (RIA) Test RIA 1-4, the first 9-rod fuel rod bundle RIA Test to be performed at BWR hot startup conditions, was completed on April 16, 1980. The test was performed in the Power Burst Facility (PBF). Objective for Test RIA 1-4 was to provide information regarding loss-of-coolable fuel rod geometry following a RIA event for a peak fuel enthalpy equivalent to the present licensing criteria of 280 cal/g. The most severe RIA is the postulated Boiling Water Reactor (BWR) control rod drop during reactor startup. Therefore the test was conducted at BWR hot startup coolant conditions (538 K, 6.45 MPa, 0.8 1/sec). The test sequence began with steady power operation to condition the fuel, establish a short-lived fission product inventory, and calibrate the calorimetric measurements and core power chambers, neutron flux and gamma flux detectors. The test train was removed from the in-pile tube (IPT) to replace one of the fuel rods with a nominally identical irradiated rod and twelve flux wire monitors. A 2.8 ms period power burst was then performed. Coolant flow measurements were made before and after the power burst to characterize the flow blockage that occurred as a result of fuel rod failure.

  18. Geophysical events

    NASA Astrophysics Data System (ADS)

    This is a summary of SEAN Bulletin, 13(2), February 29, 1988, a publication of the Smithsonian Institution's Scientific Event Alert Network. The complete bulletin is available in the microfiche edition of Eos as a microfiche supplement or as a paper reprint. For the microfiche, order document E88-002 at $2.50 (U.S.) by writing to AGU Orders, 2000 Florida Avenue, N.W., Washington, DC 20009 or by calling toll free on 800-424-2488. For the paper reprint, order SEAN Bulletin (giving volume and issue numbers and issue date) through the same address; the price is $3.50 for one copy of each issue number for those who do not have a deposit account, $2 for those who do; additional copies of each issue number are $ 1.

  19. Postulation of rust resistance genes in Nordic spring wheat genotypes and identification of widely effective sources of resistance against the Australian rust flora.

    PubMed

    Randhawa, Mandeep; Bansal, Urmil; Lillemo, Morten; Miah, Hanif; Bariana, Harbans

    2016-11-01

    Wild relatives, landraces and cultivars from different geographical regions have been demonstrated as the sources of genetic variation for resistance to rust diseases. This study involved assessment of diversity for resistance to three rust diseases among a set of Nordic spring wheat cultivars. These cultivars were tested at the seedling stage against several pathotypes of three rust pathogens in the greenhouse. All stage stem rust resistance genes Sr7b, Sr8a, Sr12, Sr15, Sr17, Sr23 and Sr30, and leaf rust resistance genes Lr1, Lr3a, Lr13, Lr14a, Lr16 and Lr20 were postulated either singly or in different combinations among these cultivars. A high proportion of cultivars were identified to carry linked rust resistance genes Sr15 and Lr20. Although 51 cultivars showed variation against Puccinia striiformis f. sp. tritici (Pst) pathotypes used in this study, results were not clearly contrasting to enable postulation of stripe rust resistance genes in these genotypes. Stripe rust resistance gene Yr27 was postulated in four cultivars and Yr1 was present in cultivar Zebra. Cultivar Tjalve produced low stripe rust response against all Pst pathotypes indicating the presence either of a widely effective resistance gene or combination of genes with compensating pathogenic specificities. Several cultivars carried moderate to high level of APR to leaf rust and stripe rust. Seedling stem rust susceptible cultivar Aston exhibited moderately resistant to moderately susceptible response, whereas other cultivars belonging to this class were rated moderately susceptible or higher. Molecular markers linked with APR genes Yr48, Lr34/Yr18/Sr57, Lr68 and Sr2 detected the presence of these genes in some genotypes.

  20. Environmental consequences of postulated radionuclide releases from the Battelle Memorial Institute Columbus Laboratories JN-1b Building at the West Jefferson site as a result of severe natural phenomena

    SciTech Connect

    Jamison, J.D.; Watson, E.C.

    1982-02-01

    Potential environmental consequences in terms of radiation dose to people are presented for postulated radionuclide releases caused by severe natural phenomena at the Battelle Memorial Institute Columbus Laboratories JN-1b Building at the West Jefferson site. The severe natural phenomena considered are earthquakes, tornadoes, and high straight-line winds. Maximum radioactive material deposition values are given for significant locations around the site. All important potential exposure pathways are examined. The most likely 50-year committed dose equivalents are given for the maximum-exposed individual and the population within a 50-mile radius of the plant. The maximum radioactive material deposition values likely to occur offsite are also given. The most likely calculated 50-year collective committed dose equivalents are all much lower than the collective dose equivalent expected from 50 years of exposure to natural background radiation and medical x-rays. The most likely maximum residual plutonium contamination estimated to be deposited offsite following the events are well below the Environmental Protection Agency's (EPA) proposed guideline for plutonium in the general environment of 0.2 ..mu..Ci/m/sup 2/. The likely maximum residual contamination from beta and gamma emitters are far below the background produced by fallout from nuclear weapons tests in the atmosphere.

  1. Events diary

    NASA Astrophysics Data System (ADS)

    2000-01-01

    as Imperial College, the Royal Albert Hall, the Royal College of Art, the Natural History and Science Museums and the Royal Geographical Society. Under the heading `Shaping the future together' BA2000 will explore science, engineering and technology in their wider cultural context. Further information about this event on 6 - 12 September may be obtained from Sandra Koura, BA2000 Festival Manager, British Association for the Advancement of Science, 23 Savile Row, London W1X 2NB (tel: 0171 973 3075, e-mail: sandra.koura@britassoc.org.uk ). Details of the creating SPARKS events may be obtained from creating.sparks@britassoc.org.uk or from the website www.britassoc.org.uk . Other events 3 - 7 July, Porto Alegre, Brazil VII Interamerican conference on physics education: The preparation of physicists and physics teachers in contemporary society. Info: IACPE7@if.ufrgs.br or cabbat1.cnea.gov.ar/iacpe/iacpei.htm 27 August - 1 September, Barcelona, Spain GIREP conference: Physics teacher education beyond 2000. Info: www.blues.uab.es/phyteb/index.html

  2. Ports Initiative

    EPA Pesticide Factsheets

    The purpose of the ports initiative is to assist EPA and other participants to formulate strategies for moving forward on actions addressing the transportation, air quality and climate issues raised in the National Conversations.

  3. Discourse Updating after Reading a Counterfactual Event

    ERIC Educational Resources Information Center

    de Vega, Manuel; Urrutia, Mabel

    2012-01-01

    This paper explores the temporal course of discourse updating after reading counterfactual events. To test the accessibility to discourse information, readers were asked to identify probes related to initial events in the text, previous to the counterfactual, or probes related to the critical counterfactual events. Experiment 1 showed that 500 ms…

  4. Geophysical events

    NASA Astrophysics Data System (ADS)

    This is a summary of SEAN Bulletin, 13 (6), June 30, 1988, a publication of the Smithsonian Institution's Scientific Event Alert Network. The complete bulletin is available in the microfiche edition of Eos as a microfiche supplement or as a paper reprint. For the microfiche, order document E88-005 at $2.50 (U.S.) by writing to AGU Orders, 2000 Florida Avenue, N.W., Washington, DC 20009 or by calling toll free on 800-424-2488. For the paper reprint, order SEAN Bulletin (giving volume and issue numbers and issue date) through the same address; the price is $3.50 for one copy of each issue number for those who do not have a deposit account, $2 for those who do; additional copies of each issue number are $ 1. Subscriptions to SEAN Bulletin are also available from AGU-Orders; the price is $18 for 12 monthly issues mailed to a U.S. address, $28 if mailed elsewhere, and must be prepaid. SEAN Bulletin is available on Kosmos. Type CHECK SEAN on Part A of Kosmos.

  5. Geophysical events

    NASA Astrophysics Data System (ADS)

    This is a summary of SEAN Bulletin, 25(10), October 31, 1988, a publication of the Smithsonian Institution's Scientific Event Alert Network. The complete bulletin is available in the microfiche edition of Eos as a microfiche supplement or as a paper reprint. For the microfiche, order document E88-010 at $2.50 (U.S.) by writing to AGU Orders, 2000 Florida Avenue, N.W., Washington, DC 20009 or by calling toll free on 800-424-2488. For the paper reprint, order SEAN Bulletin (giving volume and issue numbers and issue date) through the same address; the price is $3.50 for one copy of each issue number for those who do not have a deposit account, $2 for those who do; additional copies of each issue number are $ 1 . Subscriptions to SEAN Bulletin are also available from AGU-Orders; the price is $18 for 12 monthly issues mailed to a U.S. address, $28 if mailed elsewhere, and must be prepaid. SEAN Bulletin is available on Kosmos. Type CHECK SEAN on Part A of Kosmos

  6. Geophysical events

    NASA Astrophysics Data System (ADS)

    This is a summary of SEAN Bulletin, 13(3), March 31, 1988, a publication of the Smithsonian Institution's Scientific Event Alert Network. The complete bulletin is available in the microfiche edition of Eos as a microfiche supplement or as a paper reprint. For the microfiche, order document E88-002 at $2.50 (U.S.) by writing to AGU Orders, 2000 Florida Avenue, N.W., Washington, DC 20009 or by calling toll free on 800-424-2488. For the paper reprint, order SEAN Bulletin (giving volume and issue numbers and issue date) through the same address; the price is $3.50 for one copy of each issue number for those who do not have a deposit account, $2 for those who do; additional copies of each issue number are $1. Subscriptions to SEAN Bulletin are also available from AGU-Orders; the price is $18 for 12 monthly issues mailed to a U.S. address, $28 if mailed elsewhere, and must be prepaid.

  7. Geophysical events

    NASA Astrophysics Data System (ADS)

    This is a summary of SEAN Bulletin, 13 (7), July 31, 1988, a publication of the Smithsonian Institution's Scientific Event Alert Network. The complete bulletin is available in the microfiche edition of Eos as a microfiche supplement or as a paper reprint. For the microfiche, order document E88-007 at $2.50 (U.S.) by writing to AGU Orders, 2000 Florida Avenue, N.W., Washington, DC 20009 or by calling toll free on 800-424-2488. For the paper reprint, order SEAN Bulletin (giving volume and issue numbers and issue date) through the same address; the price is $3.50 for one copy of each issue number for those who do not have a deposit account, $2 for those who do; additional copies of each issue number are $1. Subscriptions to SEAN Bulletin are also available from AGU-Orders; the price is $18 for 12 monthly issues mailed to a U.S. address, $28 if mailed elsewhere, and must be prepaid. SEAN Bulletin is available on Kosmos. Type CHECK SEAN on Part A of Kosmos.

  8. Geophysical events

    NASA Astrophysics Data System (ADS)

    This is a summary of SEAN Bulletin, 13 (1), January 31, 1988, a publication of the Smithsonian Institution's Scientific Event Alert Network. The complete bulletin is available in the microfiche edition of Eos as a microfiche supplement or as a paper reprint. For the microfiche, order document E88-001 at $2.50 (U.S.) by writing to AGU Orders, 2000 Florida Avenue, N.W., Washington, DC 20009 or by calling toll free on 800-424-2488. For the paper reprint, order SEAN Bulletin (giving volume and issue numbers and issue date) through the same address; the price is $3.50 for one copy of each issue number for those who do not have a deposit account, $2 for those who do; additional copies of each issue number are $ 1. Subscriptions to SEAN Bulletin are also available from AGU Orders; the price is $18 for 12 monthly issues mailed to a U.S. address, $28 if mailed elsewhere, and must be prepaid.

  9. Geophysical events

    NASA Astrophysics Data System (ADS)

    This is a summary of SEAN Bulletin, 13(9), September 30, 1988, a publication of the Smithsonian Institution's Scientific Event Alert Network. The complete bulletin is available in the microfiche edition of Eos as a microfiche supplement or as a paper reprint. For the microfiche, order document E88-013 at $2.50 (U.S.) by writing to AGU Orders, 2000 Florida Avenue, N.W., Washington, DC 20009 or by calling toll free on 800-424-2488. For the paper reprint, order SEAN Bulletin (giving volume and issue numbers and issue date) through the same address; the price is $3.50 for one copy of each issue number for those who do not have a deposit account, $2 for those who do; additional copies of each issue number are $1. Subscriptions to SEAN Bulletin are also available from AGU-Orders; the price is $18 for 12 monthly issues mailed to a U.S. address, $28 if mailed elsewhere, and must be prepaid. SEAN Bulletin is available on Kosmos. Type CHECK SEAN on Part A of Kosmos.

  10. Geophysical events

    NASA Astrophysics Data System (ADS)

    This is a summary of SEAN Bulletin, 13 (5), May 31, 1988, a publication of the Smithsonian Institution's Scientific Event Alert Network. The complete bulletin is available in the microfiche edition of Eos as a microfiche supplement or as a paper reprint. For the microfiche, order document E88-004 at $2.50 (U.S.) by writing to AGU Orders, 2000 Florida Avenue, N.W., Washington, DC 20009 or by calling toll free on 800-424-2488. For the paper reprint, order SEAN Bulletin (giving volume and issue numbers and issue date) through the same address; the price is $3.50 for one copy of each issue number for those who do not have a deposit account, $2 for those who do; additional copies of each issue number are $ 1. Subscriptions to SEAN Bulletin are also available from AGU-Orders; the price is $18 for 12 monthly issues mailed to a U.S. address, $28 if mailed elsewhere, and must be prepaid. SEAN Bulletin is available on Kosmos. Type CHECK SEAN on Part A of Kosmos.

  11. Sweepoviruses Cause Disease in Sweet Potato and Related Ipomoea spp.: Fulfilling Koch's Postulates for a Divergent Group in the Genus Begomovirus

    PubMed Central

    Márquez-Martín, Belén; Moriones, Enrique; Navas-Castillo, Jesús

    2011-01-01

    Sweet potato (Ipomoea batatas) and related Ipomoea species are frequently infected by monopartite begomoviruses (genus Begomovirus, family Geminiviridae), known as sweepoviruses. Unlike other geminiviruses, the genomes of sweepoviruses have been recalcitrant to rendering infectious clones to date. Thus, Koch's postulates have not been fullfilled for any of the viruses in this group. Three novel species of sweepoviruses have recently been described in Spain: Sweet potato leaf curl Lanzarote virus (SPLCLaV), Sweet potato leaf curl Spain virus (SPLCSV) and Sweet potato leaf curl Canary virus (SPLCCaV). Here we describe the generation of the first infectious clone of an isolate (ES:MAL:BG30:06) of SPLCLaV. The clone consisted of a complete tandem dimeric viral genome in a binary vector. Successful infection by agroinoculation of several species of Ipomoea (including sweet potato) and Nicotiana benthamiana was confirmed by PCR, dot blot and Southern blot hybridization. Symptoms observed in infected plants consisted of leaf curl, yellowing, growth reduction and vein yellowing. Two varieties of sweet potato, ‘Beauregard’ and ‘Promesa’, were infected by agroinoculation, and symptoms of leaf curl and interveinal loss of purple colouration were observed, respectively. The virus present in agroinfected plants was readily transmitted by the whitefly Bemisia tabaci to I. setosa plants. The progeny virus population present in agroinfected I. setosa and sweet potato plants was isolated and identity to the original isolate was confirmed by sequencing. Therefore, Koch's postulates were fulfilled for the first time for a sweepovirus. PMID:22073314

  12. Event segmentation ability uniquely predicts event memory.

    PubMed

    Sargent, Jesse Q; Zacks, Jeffrey M; Hambrick, David Z; Zacks, Rose T; Kurby, Christopher A; Bailey, Heather R; Eisenberg, Michelle L; Beck, Taylor M

    2013-11-01

    Memory for everyday events plays a central role in tasks of daily living, autobiographical memory, and planning. Event memory depends in part on segmenting ongoing activity into meaningful units. This study examined the relationship between event segmentation and memory in a lifespan sample to answer the following question: Is the ability to segment activity into meaningful events a unique predictor of subsequent memory, or is the relationship between event perception and memory accounted for by general cognitive abilities? Two hundred and eight adults ranging from 20 to 79years old segmented movies of everyday events and attempted to remember the events afterwards. They also completed psychometric ability tests and tests measuring script knowledge for everyday events. Event segmentation and script knowledge both explained unique variance in event memory above and beyond the psychometric measures, and did so as strongly in older as in younger adults. These results suggest that event segmentation is a basic cognitive mechanism, important for memory across the lifespan.

  13. Youth Initiatives.

    ERIC Educational Resources Information Center

    Employment and Training Administration (DOL), Washington, DC. Office of Youth Programs.

    Summarizing the first eight months of the planning, design, and implementation of the new federal youth programs created by the Youth Employment and Demonstration Projects Act of 1977 (YEDPA) and the efforts for expansion and enrichment of the Job Corps, this report explains the charters of the two projects and their initial successes in and…

  14. Keep off the grass: marijuana use and acute cardiovascular events.

    PubMed

    Caldicott, David G E; Holmes, James; Roberts-Thomson, Kurt C; Mahar, Leo

    2005-10-01

    Marijuana is one of the most widely used recreational substances in the world, considered by many consumers as a relatively safe drug with few significant side-effects. We report the case of a 21-year-old man who suffered an acute myocardial infarction following the use of marijuana, despite having no other identifiable risk factors for an acute cardiovascular event. We review the published medical literature regarding acute cardiovascular events following marijuana use and postulate a possible mechanism for this unusual pathological consequence of marijuana use.

  15. Facile synthesis of two diastereomeric indolizidines corresponding to the postulated structure of alkaloid 5,9E-259B from a Bufonid toad (Melanophryniscus)

    PubMed Central

    Nelson, Angela; Garraffo, H Martin; Spande, Thomas F; Daly, John W; Stevenson, Paul J

    2008-01-01

    A short synthesis of the postulated structure for indolizidine alkaloid 259B with the hydrogens at C5 and C9 entgegen has been achieved with complete control of stereochemistry at C5. Both diastereoisomers at C8 were obtained, but neither proved to be the natural product. The comparison of the mass and FTIR spectral properties of the synthetic compounds to those of the natural material strongly suggest that the gross structure is correct and that the difference may be a branch in the C5 alkyl side-chain. The GC-retention times of the two synthetic compounds were markedly longer than that of the natural 5,9E-259B. PMID:18208586

  16. SCB initiator

    DOEpatents

    Bickes Jr., Robert W.; Renlund, Anita M.; Stanton, Philip L.

    1994-11-01

    A detonator for high explosives initiated by mechanical impact includes a cylindrical barrel, a layer of flyer material mechanically covering the barrel at one end, and a semiconductor bridge ignitor including a pair of electrically conductive pads connected by a semiconductor bridge. The bridge is in operational contact with the layer, whereby ignition of said bridge forces a portion of the layer through the barrel to detonate the explosive. Input means are provided for igniting the semiconductor bridge ignitor.

  17. SCB initiator

    SciTech Connect

    Bickes, Jr., Robert W.; Renlund, Anita M.; Stanton, Philip L.

    1994-01-01

    A detonator for high explosives initiated by mechanical impact includes a cylindrical barrel, a layer of flyer material mechanically covering the barrel at one end, and a semiconductor bridge ignitor including a pair of electrically conductive pads connected by a semiconductor bridge. The bridge is in operational contact with the layer, whereby ignition of said bridge forces a portion of the layer through the barrel to detonate the explosive. Input means are provided for igniting the semiconductor bridge ignitor.

  18. Lessons from the Chelyabinsk event

    NASA Astrophysics Data System (ADS)

    Emel'Yanenko, Vacheslav V.

    2016-01-01

    Recent investigations on small asteroids, initiated by the Chelyabinsk event, are reviewed. New estimates of the terrestrial impact rate, importance of Sun-grazing conditions in the evolution of near-Earth objects, and problems associated with dangerous objects approaching the Earth from the Sun direction are discussed.

  19. Creating Special Events

    ERIC Educational Resources Information Center

    deLisle, Lee

    2009-01-01

    "Creating Special Events" is organized as a systematic approach to festivals and events for students who seek a career in event management. This book looks at the evolution and history of festivals and events and proceeds to the nuts and bolts of event management. The book presents event management as the means of planning, organizing, directing,…

  20. Cross sections for the reactions e+e-→KS0KL0π0 , KS0KL0η , and KS0KL0π0π0 from events with initial-state radiation

    NASA Astrophysics Data System (ADS)

    Lees, J. P.; Poireau, V.; Tisserand, V.; Grauges, E.; Palano, A.; Eigen, G.; Brown, D. N.; Kolomensky, Yu. G.; Fritsch, M.; Koch, H.; Schroeder, T.; Hearty, C.; Mattison, T. S.; McKenna, J. A.; So, R. Y.; Blinov, V. E.; Buzykaev, A. R.; Druzhinin, V. P.; Golubev, V. B.; Kravchenko, E. A.; Onuchin, A. P.; Serednyakov, S. I.; Skovpen, Yu. I.; Solodov, E. P.; Todyshev, K. Yu.; Lankford, A. J.; Gary, J. W.; Long, O.; Eisner, A. M.; Lockman, W. S.; Panduro Vazquez, W.; Chao, D. S.; Cheng, C. H.; Echenard, B.; Flood, K. T.; Hitlin, D. G.; Kim, J.; Miyashita, T. S.; Ongmongkolkul, P.; Porter, F. C.; Röhrken, M.; Huard, Z.; Meadows, B. T.; Pushpawela, B. G.; Sokoloff, M. D.; Sun, L.; Smith, J. G.; Wagner, S. R.; Bernard, D.; Verderi, M.; Bettoni, D.; Bozzi, C.; Calabrese, R.; Cibinetto, G.; Fioravanti, E.; Garzia, I.; Luppi, E.; Santoro, V.; Calcaterra, A.; de Sangro, R.; Finocchiaro, G.; Martellotti, S.; Patteri, P.; Peruzzi, I. M.; Piccolo, M.; Rotondo, M.; Zallo, A.; Passaggio, S.; Patrignani, C.; Lacker, H. M.; Bhuyan, B.; Mallik, U.; Chen, C.; Cochran, J.; Prell, S.; Ahmed, H.; Gritsan, A. V.; Arnaud, N.; Davier, M.; Le Diberder, F.; Lutz, A. M.; Wormser, G.; Lange, D. J.; Wright, D. M.; Coleman, J. P.; Gabathuler, E.; Hutchcroft, D. E.; Payne, D. J.; Touramanis, C.; Bevan, A. J.; Di Lodovico, F.; Sacco, R.; Cowan, G.; Banerjee, Sw.; Brown, D. N.; Davis, C. L.; Denig, A. G.; Gradl, W.; Griessinger, K.; Hafner, A.; Schubert, K. R.; Barlow, R. J.; Lafferty, G. D.; Cenci, R.; Jawahery, A.; Roberts, D. A.; Cowan, R.; Robertson, S. H.; Dey, B.; Neri, N.; Palombo, F.; Cheaib, R.; Cremaldi, L.; Godang, R.; Summers, D. J.; Taras, P.; De Nardo, G.; Sciacca, C.; Raven, G.; Jessop, C. P.; LoSecco, J. M.; Honscheid, K.; Kass, R.; Gaz, A.; Margoni, M.; Posocco, M.; Simi, G.; Simonetto, F.; Stroili, R.; Akar, S.; Ben-Haim, E.; Bomben, M.; Bonneaud, G. R.; Calderini, G.; Chauveau, J.; Marchiori, G.; Ocariz, J.; Biasini, M.; Manoni, E.; Rossi, A.; Batignani, G.; Bettarini, S.; Carpinelli, M.; Casarosa, G.; Chrzaszcz, M.; Forti, F.; Giorgi, M. A.; Lusiani, A.; Oberhof, B.; Paoloni, E.; Rama, M.; Rizzo, G.; Walsh, J. J.; Smith, A. J. S.; Anulli, F.; Faccini, R.; Ferrarotto, F.; Ferroni, F.; Pilloni, A.; Piredda, G.; Bünger, C.; Dittrich, S.; Grünberg, O.; Heß, M.; Leddig, T.; Voß, C.; Waldi, R.; Adye, T.; Wilson, F. F.; Emery, S.; Vasseur, G.; Aston, D.; Cartaro, C.; Convery, M. R.; Dorfan, J.; Dunwoodie, W.; Ebert, M.; Field, R. C.; Fulsom, B. G.; Graham, M. T.; Hast, C.; Innes, W. R.; Kim, P.; Leith, D. W. G. S.; Luitz, S.; MacFarlane, D. B.; Muller, D. R.; Neal, H.; Ratcliff, B. N.; Roodman, A.; Sullivan, M. K.; Va'vra, J.; Wisniewski, W. J.; Purohit, M. V.; Wilson, J. R.; Randle-Conde, A.; Sekula, S. J.; Bellis, M.; Burchat, P. R.; Puccio, E. M. T.; Alam, M. S.; Ernst, J. A.; Gorodeisky, R.; Guttman, N.; Peimer, D. R.; Soffer, A.; Spanier, S. M.; Ritchie, J. L.; Schwitters, R. F.; Izen, J. M.; Lou, X. C.; Bianchi, F.; De Mori, F.; Filippi, A.; Gamba, D.; Lanceri, L.; Vitale, L.; Martinez-Vidal, F.; Oyanguren, A.; Albert, J.; Beaulieu, A.; Bernlochner, F. U.; King, G. J.; Kowalewski, R.; Lueck, T.; Nugent, I. M.; Roney, J. M.; Sobie, R. J.; Tasneem, N.; Gershon, T. J.; Harrison, P. F.; Latham, T. E.; Prepost, R.; Wu, S. L.; BaBar Collaboration

    2017-03-01

    We study the processes e+e- →KS0KL0π0 γ , KS0KL0η γ , and KS0KL0π0π0 γ , where the photon is radiated from the initial state, providing cross section measurements for the hadronic final states over a continuum of center-of-mass energies. The results are based on 469 fb-1 of data collected at or near the Υ (4 S ) resonance with the BABAR detector at SLAC. We present the first measurements of the e+e- →KS0KL0π0 , KS0KL0η , and KS0KL0π0π0 cross sections up to a center-of-mass energy of 4 GeV and study their intermediate resonance structures. We observe J /ψ decays to all of these final states for the first time, present measurements of their J /ψ branching fractions, and search for ψ (2 S ) decays.

  1. [Emergency drills and exercises to prepare the initial response and countermeasures for a disaster: an evacuation simulation for the hospital's outpatient blood collection room in the event of an earthquake].

    PubMed

    Kaneko, Makoto; Nakao, Hiroyuki; Morita, Kazuharu; Sone, Shinji; Masuda, Akiko; Yatomi, Yutaka

    2013-12-01

    In case of a disaster, the clinical laboratory's departmental staff is not only responsible for recovery efforts of routine work and the continuation of emergency tests, but also for protecting patients against both dangers and possible risks in the blood collecting room and physiology laboratory. For this reason, we decided to participate in an emergency drill, which focuses on the initial response to a disaster, specifically evacuation procedures and the cessation of phlebotomy operations. Since there were no existing manuals regarding disasters in our blood collection room, we first made a draft disaster plan. Additionally, since we were absolute beginners with regard to training and had inadequate knowledge of disaster countermeasures, we conducted theoretical simulations in advance. We decided to explain the evacuation details and had each participant in the exercise perform their own role in accordance with our scenario. Furthermore, we asked the participants to discuss the effectiveness of the training and seek out ways to improve our manuals. Although this was the first practice for the blood collection room, we were able to achieve our first goal by raising awareness of disaster prevention activities. The precautions against disaster that eliminate accidents require an immense amount of time and effort. Thus, it is necessary to continue training in order to increase the staffs awareness of disaster defense and to continue to improve our skills in the future.

  2. An increase in liver PPARγ2 is an initial event to induce fatty liver in response to a diet high in butter: PPARγ2 knockdown improves fatty liver induced by high-saturated fat.

    PubMed

    Yamazaki, Tomomi; Shiraishi, Sayaka; Kishimoto, Kyoko; Miura, Shinji; Ezaki, Osamu

    2011-06-01

    The effects of a diet rich in saturated fat on fatty liver formation and the related mechanisms that induce fatty liver were examined. C57BL/6J mice were fed butter or safflower oil as a high-fat (HF) diet (40% fat calories) for 2, 4, 10, or 17 weeks. Although both HF diets induced similar levels of obesity, HF butter-fed mice showed a two to threefold increase in liver triacylglycerol (TG) concentration compared to HF safflower oil-fed mice at 4 or 10 weeks without hyperinsulinemia. At 4 weeks, increases in peroxisome proliferator-activated receptor γ2 (PPARγ2), CD36, and adipose differentiation-related protein (ADRP) mRNAs were observed in HF butter-fed mice; at 10 weeks, an increase in sterol regulatory element-binding protein-1c (SREBP-1c) was observed; at 17 weeks, these increases were attenuated. At 4 weeks, a single injection of adenoviral vector-based short hairpin interfering RNA against PPARγ2 in HF butter-fed mice reduced PPARγ protein and mRNA of its target genes (CD36 and ADRP) by 43%, 43%, and 39%, respectively, with a reduction in liver TG concentration by 38% in 5 days. PPARγ2 knockdown also reduced mRNAs in lipogenic genes (fatty-acid-synthase, stearoyl-CoA desaturase 1, acetyl-CoA carboxylase 1) without alteration of SREBP-1c mRNA. PPARγ2 knockdown reduced mRNAs in genes related to inflammation (CD68, interleukin-1β, tumor necrosis factor-α, and monocyte chemoattractant protein-1). In conclusion, saturated fatty acid-rich oil induced fatty liver in mice, and this was triggered initially by an increase in PPARγ2 protein in the liver, which led to increased expression of lipogenic genes. Inactivation of PPARγ2 may improve fatty liver induced by HF saturated fat.

  3. Assessment of a large break loss of coolant accident scenario requiring operator action to initiate safety injection

    SciTech Connect

    Grendys, R.C.; Nissley, M.E.; Baker, D.C.

    1996-11-01

    As part of the licensing basis for a nuclear power plant, the acceptability of the Emergency Core Cooling Systems (ECCS) following a postulated Loss-of-Coolant Accident (LOCA) as described in the Code of Federal Regulations (CFR), Title 10, Chapter 1, Part 50.46, must be verified. The LOCA analysis is performed with an acceptable ECCS Evaluation Model and results must show compliance with the 10 CFR 50.46 acceptance criteria. Westinghouse Electric Corporation performs Large and Small Break LOCA and LOCA-related analyses to support the licensing basis of various nuclear power plants and also performs evaluations against the licensing basis analyses as required. Occasionally, the need arises for the holder of an operating license of a nuclear power plant to submit a Licensee Event Report (LER) to the US Nuclear Regulatory Commission (USNRC) for any event of the type described in the Code of Federal Regulations, Title 10, Chapter 1, Part 50.73. To support the LER, a Justification for Past Operation (JPO) may be performed to assess the safety consequences and implications of the event based on previous operating conditions. This paper describes the work performed for the Large Break LOCA to assess the impact of an event discovered by Florida Power and Light and reported in LER-94-005-02. For this event, it was determined that under certain circumstances, operator action would have been required to initiate safety injection (SI), thus challenging the acceptability of the ECCS. This event was specifically addressed for the Large Break LOCA by using an advanced thermal hydraulic analysis methodology with realistic input assumptions.

  4. A model for the release, dispersion and environmental impact of a postulated reactor accident from a submerged commercial nuclear power plant

    NASA Astrophysics Data System (ADS)

    Bertch, Timothy Creston

    1998-12-01

    Nuclear power plants are inherently suitable for submerged applications and could provide power to the shore power grid or support future underwater applications. The technology exists today and the construction of a submerged commercial nuclear power plant may become desirable. A submerged reactor is safer to humans because the infinite supply of water for heat removal, particulate retention in the water column, sedimentation to the ocean floor and inherent shielding of the aquatic environment would significantly mitigate the effects of a reactor accident. A better understanding of reactor operation in this new environment is required to quantify the radioecological impact and to determine the suitability of this concept. The impact of release to the environment from a severe reactor accident is a new aspect of the field of marine radioecology. Current efforts have been centered on radioecological impacts of nuclear waste disposal, nuclear weapons testing fallout and shore nuclear plant discharges. This dissertation examines the environmental impact of a severe reactor accident in a submerged commercial nuclear power plant, modeling a postulated site on the Atlantic continental shelf adjacent to the United States. This effort models the effects of geography, decay, particle transport/dispersion, bioaccumulation and elimination with associated dose commitment. The use of a source term equivalent to the release from Chernobyl allows comparison between the impacts of that accident and the postulated submerged commercial reactor plant accident. All input parameters are evaluated using sensitivity analysis. The effect of the release on marine biota is determined. Study of the pathways to humans from gaseous radionuclides, consumption of contaminated marine biota and direct exposure as contaminated water reaches the shoreline is conducted. The model developed by this effort predicts a significant mitigation of the radioecological impact of the reactor accident release

  5. An Initial Event in Insect Innate Immune Response: Structural and Biological Studies of Interactions between β-1,3-glucan and the N-terminal Domain of β-1,3-glucan Recognition Protein

    PubMed Central

    Dai, Huaien; Hiromasa, Yasuaki; Takahashi, Daisuke; VanderVelde, David; Fabrick, Jeffrey A.; Kanost, Michael R.; Krishnamoorthi, Ramaswamy

    2012-01-01

    ligand-bound protein molecules contribute in part to the stability of N-βGRP:laminarin macro complex and that a decreased stability is accompanied by a reduced activation of the proPO pathway. Increased β-1,6 branching in laminarin also results in destabilization of the macro complex. These novel findings suggest that ligand-induced self-association of βGRP:β-1,3-glucan complex may form a platform on a microbial surface for recruitment of downstream proteases, as a means of amplification of the initial signal of pathogen recognition for the activation of the proPO pathway. PMID:23237493

  6. Event-by-event elliptic flow fluctuations from PHOBOS.

    SciTech Connect

    Alver, B.; Back, B. B.; Baker, M. D.; Ballintijn, M.; Barton, D. S.; Physics; BNL; Inst. of Nuclear Physics; Massachusetts Inst. of Tech.; National Central Univ.; Univ. of Maryland; Univ. of Rochester

    2009-04-01

    Recently PHOBOS has focused on the study of fluctuations and correlations in particle production in heavy-ion collisions at the highest energies delivered by the Relativistic Heavy Ion Collider (RHIC). In this report, we present results on event-by-event elliptic flow fluctuations in Au + Au collisions at {radical}s{sub NN} = 200 GeV. A data-driven method was used to estimate the dominant contribution from non-flow correlations. Over the broad range of collision centralities, the observed large elliptic flow fluctuations are in agreement with the fluctuations in the initial source eccentricity.

  7. Supplementary documentation for an Environmental Impact Statement regarding the Pantex Plant: radiological consequences of immediate inhalation of plutonium dispersed by postulated accidents

    SciTech Connect

    Elder, J.C.; Olsher, R.H.; Graf, J.M.

    1982-12-01

    This report documents work performed in support of preparation of an Environmental Impact Statement (EIS) regarding the Department of Energy's (DOE) Pantex Plant near Amarillo, Texas. It describes methods used to estimate potential health consequences offsite resulting from inhalation of plutonium dispersed by each of several postulated accidents. The primary topic of this report is the delayed health effects of the plutonium in a nonnuclear detonation debris inhaled directly by members of the population in the cloud path. The expected form and size of the plutonium particles are derived from experimental data obatined in the Roller Coaster test series of 1963. Retention characteristics based on the International Commission on Radiation Protection (ICRP) Task Group Lung Model and organ dose calculations based on a modified computer model are described. Health risk estimates based on organ dose are made using appropriate risk factors recommended by international radiation protection organizations. The relative seriousness of each accident at each alternative site is assessed on the basis of the health risk estiamtes.

  8. Health information seeking and scanning among US adults aged 50-75 years: Testing a key postulate of the information overload model.

    PubMed

    Jensen, Jakob D; Liu, Miao; Carcioppolo, Nick; John, Kevin K; Krakow, Melinda; Sun, Ye

    2016-02-23

    Past research has found that older US adults (aged 50-75 years) exhibit high levels of cancer information overload and cancer worry; however, no study to date has examined whether these perceptions are related to information seeking/scanning. To explore this relationship, older adults (N = 209, Mage = 55.56, SD = 4.24) were recruited to complete a survey measuring seeking, scanning, cancer information overload, and cancer worry. Most participants were high-scan/seekers (40.2%) followed by low-scan/seekers (21.1%), high-scan/no seekers (19.6%), and low-scan/no seekers (19.1%). Low-scan/no seekers had significantly higher cancer information overload compared to all other groups, consistent with the postulate that overload and seeking/scanning are negatively related. Low-scan/no seekers and high-scan/seekers both exhibited higher cancer worry severity, consistent with past research suggesting that cancer worry explains high levels of activity/inactivity.

  9. Environmental consequences of postulated plutonium releases from General Electric Company Vallecitos Nuclear Center, Vallecitos, California, as a result of severe natural phenomena

    SciTech Connect

    Jamison, J.D.; Watson, E.C.

    1980-11-01

    Potential environmental consequences in terms of radiation dose to people are presented for postulated plutonium releases caused by severe natural phenomena at the General Electric Company Vallecitos Nuclear Center, Vallecitos, California. The severe natural phenomena considered are earthquakes, tornadoes, and high straight-line winds. Maximum plutonium deposition values are given for significant locations around the site. All important potential exposure pathways are examined. The most likely 50-year committed dose equivalents are given for the maximum-exposed individual and the population within a 50-mile radius of the plant. The maximum plutonium deposition values likely to occur offsite are also given. The most likely calculated 50-year collective committed dose equivalents are all much lower than the collective dose equivalent expected from 50 years of exposure to natural background radiation and medical x-rays. The most likely maximum residual plutonium contamination estimated to be deposited offsite following the earthquakes, and the 180-mph and 230-mph tornadoes are above the Environmental Protection Agency's (EPA) proposed guideline for plutonium in the general environment of 0.2 ..mu..Ci/m/sup 2/. The deposition values following the 135-mph tornado are below the EPA proposed guidelines.

  10. Environmental consequences of postulate plutonium releases from Atomics International's Nuclear Materials Development Facility (NMDF), Santa Susana, California, as a result of severe natural phenomena

    SciTech Connect

    Jamison, J.D.; Watson, E.C.

    1982-02-01

    Potential environmental consequences in terms of radiation dose to people are presented for postulated plutonium releases caused by severe natural phenomena at the Atomics International's Nuclear Materials Development Facility (NMDF), in the Santa Susana site, California. The severe natural phenomena considered are earthquakes, tornadoes, and high straight-line winds. Plutonium deposition values are given for significant locations around the site. All important potential exposure pathways are examined. The most likely 50-year committed dose equivalents are given for the maximum-exposed individual and the population within a 50-mile radius of the plant. The maximum plutonium deposition values likely to occur offsite are also given. The most likely calculated 50-year collective committed dose equivalents are all much lower than the collective dose equivalent expected from 50 years of exposure to natural background radiation and medical x-rays. The most likely maximum residual plutonium contamination estimated to be deposited offsite following the earthquake, and the 150-mph and 170-mph tornadoes are above the Environmental Protection Agency's (EPA) proposed guideline for plutonium in the general environment of 0.2 ..mu..Ci/m/sup 2/. The deposition values following the 110-mph and the 130-mph tornadoes are below the EPA proposed guideline.

  11. Assessing Special Events.

    ERIC Educational Resources Information Center

    Neff, Bonita Dostal

    Special events defined as being "newsworthy events" are becoming a way of American life. They are also a means for making a lot of money. Examples of special events that are cited most frequently are often the most minor of events; e.g., the open house, the new business opening day gala, or a celebration of some event in an organization.…

  12. Event Segmentation Ability Uniquely Predicts Event Memory

    PubMed Central

    Sargent, Jesse Q.; Zacks, Jeffrey M.; Hambrick, David Z.; Zacks, Rose T.; Kurby, Christopher A.; Bailey, Heather R.; Eisenberg, Michelle L.; Beck, Taylor M.

    2013-01-01

    Memory for everyday events plays a central role in tasks of daily living, autobiographical memory, and planning. Event memory depends in part on segmenting ongoing activity into meaningful units. This study examined the relationship between event segmentation and memory in a lifespan sample to answer the following question: Is the ability to segment activity into meaningful events a unique predictor of subsequent memory, or is the relationship between event perception and memory accounted for by general cognitive abilities? Two hundred and eight adults ranging from 20 to 79 years old segmented movies of everyday events and attempted to remember the events afterwards. They also completed psychometric ability tests and tests measuring script knowledge for everyday events. Event segmentation and script knowledge both explained unique variance in event memory above and beyond the psychometric measures, and did so as strongly in older as in younger adults. These results suggest that event segmentation is a basic cognitive mechanism, important for memory across the lifespan. PMID:23942350

  13. Openness initiative

    SciTech Connect

    Duncan, S.S.

    1995-12-31

    Although antinuclear campaigns seem to be effective, public communication and education efforts on low-level radioactive waste have mixed results. Attempts at public information programs on low-level radioactive waste still focus on influencing public opinion. A question then is: {open_quotes}Is it preferable to have a program focus on public education that will empower individuals to make informed decisions rather than trying to influence them in their decisions?{close_quotes} To address this question, a case study with both quantitative and qualitative data will be used. The Ohio Low-Level Radioactive Waste Education Program has a goal to provide people with information they want/need to make their own decisions. The program initiated its efforts by conducting a statewide survey to determine information needed by people and where they turned for that information. This presentation reports data from the survey and then explores the program development process in which programs were designed and presented using the information. Pre and post data from the programs reveal attitude and knowledge shifts.

  14. Disruptive Event Biosphere Doser Conversion Factor Analysis

    SciTech Connect

    M. Wasiolek

    2000-12-28

    The purpose of this report was to document the process leading to, and the results of, development of radionuclide-, exposure scenario-, and ash thickness-specific Biosphere Dose Conversion Factors (BDCFs) for the postulated postclosure extrusive igneous event (volcanic eruption) at Yucca Mountain. BDCF calculations were done for seventeen radionuclides. The selection of radionuclides included those that may be significant dose contributors during the compliance period of up to 10,000 years, as well as radionuclides of importance for up to 1 million years postclosure. The approach documented in this report takes into account human exposure during three different phases at the time of, and after, volcanic eruption. Calculations of disruptive event BDCFs used the GENII-S computer code in a series of probabilistic realizations to propagate the uncertainties of input parameters into the output. The pathway analysis included consideration of different exposure pathway's contribution to the BDCFs. BDCFs for volcanic eruption, when combined with the concentration of radioactivity deposited by eruption on the soil surface, allow calculation of potential radiation doses to the receptor of interest. Calculation of radioactivity deposition is outside the scope of this report and so is the transport of contaminated ash from the volcano to the location of the receptor. The integration of the biosphere modeling results (BDCFs) with the outcomes of the other component models is accomplished in the Total System Performance Assessment (TSPA), in which doses are calculated to the receptor of interest from radionuclides postulated to be released to the environment from the potential repository at Yucca Mountain.

  15. Hydrodynamics from Landau initial conditions

    SciTech Connect

    Sen, Abhisek; Gerhard, Jochen; Torrieri, Giorgio; Read jr, Kenneth F.; Wong, Cheuk-Yin

    2015-01-01

    We investigate ideal hydrodynamic evolution, with Landau initial conditions, both in a semi-analytical 1+1D approach and in a numerical code incorporating event-by-event variation with many events and transverse density inhomogeneities. The object of the calculation is to test how fast would a Landau initial condition transition to a commonly used boost-invariant expansion. We show that the transition to boost-invariant flow occurs too late for realistic setups, with corrections of O (20 - 30%) expected at freezeout for most scenarios. Moreover, the deviation from boost-invariance is correlated with both transverse flow and elliptic flow, with the more highly transversely flowing regions also showing the most violation of boost invariance. Therefore, if longitudinal flow is not fully developed at the early stages of heavy ion collisions, 2+1 dimensional hydrodynamics is inadequate to extract transport coefficients of the quark-gluon plasma. Based on [1, 2

  16. Microdrill Initiative - Initial Market Evaluation

    SciTech Connect

    Spears & Associates, Inc

    2003-07-01

    The U.S. Department of Energy (DOE) is launching a major research and development initiative to create a small, fast, inexpensive and environmentally friendly rig for drilling 5000 feet boreholes to investigate potential oil and gas reservoirs. DOE wishes to get input from petroleum industry operators, service companies and equipment suppliers on the operation and application of this coiled-tubing-based drilling unit. To that end, DOE has asked Spears & Associates, Inc. (SAI) to prepare a special state-of-the-market report and assist during a DOE-sponsored project-scoping workshop in Albuquerque near the end of April 2003. The scope of the project is four-fold: (1) Evaluate the history, status and future of demand for very small bore-hole drilling; (2) Measure the market for coiled tubing drilling and describe the state-of-the-art; (3) Identify companies and individuals who should have an interest in micro drilling and invite them to the DOE workshop; and (4) Participate in 3 concurrent workshop sessions, record and evaluate participant comments and report workshop conclusions.

  17. The ancient tropical rainforest tree Symphonia globulifera L. f. (Clusiaceae) was not restricted to postulated Pleistocene refugia in Atlantic Equatorial Africa

    PubMed Central

    Budde, K B; González-Martínez, S C; Hardy, O J; Heuertz, M

    2013-01-01

    Understanding the history of forests and their species' demographic responses to past disturbances is important for predicting impacts of future environmental changes. Tropical rainforests of the Guineo-Congolian region in Central Africa are believed to have survived the Pleistocene glacial periods in a few major refugia, essentially centred on mountainous regions close to the Atlantic Ocean. We tested this hypothesis by investigating the phylogeographic structure of a widespread, ancient rainforest tree species, Symphonia globulifera L. f. (Clusiaceae), using plastid DNA sequences (chloroplast DNA [cpDNA], psbA-trnH intergenic spacer) and nuclear microsatellites (simple sequence repeats, SSRs). SSRs identified four gene pools located in Benin, West Cameroon, South Cameroon and Gabon, and São Tomé. This structure was also apparent at cpDNA. Approximate Bayesian Computation detected recent bottlenecks approximately dated to the last glacial maximum in Benin, West Cameroon and São Tomé, and an older bottleneck in South Cameroon and Gabon, suggesting a genetic effect of Pleistocene cycles of forest contraction. CpDNA haplotype distribution indicated wide-ranging long-term persistence of S. globulifera both inside and outside of postulated forest refugia. Pollen flow was four times greater than that of seed in South Cameroon and Gabon, which probably enabled rapid population recovery after bottlenecks. Furthermore, our study suggested ecotypic differentiation—coastal or swamp vs terra firme—in S. globulifera. Comparison with other tree phylogeographic studies in Central Africa highlighted the relevance of species-specific responses to environmental change in forest trees. PMID:23572126

  18. The ancient tropical rainforest tree Symphonia globulifera L. f. (Clusiaceae) was not restricted to postulated Pleistocene refugia in Atlantic Equatorial Africa.

    PubMed

    Budde, K B; González-Martínez, S C; Hardy, O J; Heuertz, M

    2013-07-01

    Understanding the history of forests and their species' demographic responses to past disturbances is important for predicting impacts of future environmental changes. Tropical rainforests of the Guineo-Congolian region in Central Africa are believed to have survived the Pleistocene glacial periods in a few major refugia, essentially centred on mountainous regions close to the Atlantic Ocean. We tested this hypothesis by investigating the phylogeographic structure of a widespread, ancient rainforest tree species, Symphonia globulifera L. f. (Clusiaceae), using plastid DNA sequences (chloroplast DNA [cpDNA], psbA-trnH intergenic spacer) and nuclear microsatellites (simple sequence repeats, SSRs). SSRs identified four gene pools located in Benin, West Cameroon, South Cameroon and Gabon, and São Tomé. This structure was also apparent at cpDNA. Approximate Bayesian Computation detected recent bottlenecks approximately dated to the last glacial maximum in Benin, West Cameroon and São Tomé, and an older bottleneck in South Cameroon and Gabon, suggesting a genetic effect of Pleistocene cycles of forest contraction. CpDNA haplotype distribution indicated wide-ranging long-term persistence of S. globulifera both inside and outside of postulated forest refugia. Pollen flow was four times greater than that of seed in South Cameroon and Gabon, which probably enabled rapid population recovery after bottlenecks. Furthermore, our study suggested ecotypic differentiation-coastal or swamp vs terra firme-in S. globulifera. Comparison with other tree phylogeographic studies in Central Africa highlighted the relevance of species-specific responses to environmental change in forest trees.

  19. Enhancing Decision Making during Initial Operations at Surge Events

    DTIC Science & Technology

    2012-12-01

    and considered to be a novice when commanding the response to a release of sulfuric acid . The concept of naturalistic decision making was further...Crisis, Disaster and Risk Management, 2002. 261. 41 Ibid., 257. 42 U.S. Department of Commerce. National Oceanic and Atmospheric Administration...Situation Awareness and Decision-making in a Warning Environment (Washington, DC: National Oceanic and Atmospheric Administration. 7. 18 which

  20. Albedo maps of Pluto and Charon - Initial mutual event results

    NASA Technical Reports Server (NTRS)

    Buie, Marc W.; Tholen, David J.; Horne, Keith

    1992-01-01

    By applying the technique of maximum entropy image reconstruction to invert observed lightcurves, surface maps of single-scattering albedo are obtained for the surfaces of Pluto and Charon from 1954 to 1986. The albedo features of the surface of Pluto are similar to those of the Buie and Tholen (1989) spot model maps; a south polar cap is evident. The map of Charon is somewhat darker, with single-scattering albedos as low as 0.03.

  1. Learning to Describe Events.

    ERIC Educational Resources Information Center

    Duchan, Judith Felson

    1986-01-01

    The article discusses language structures of three hierarchical levels of event descriptions: (1) single-action events (semantic relations, aspectual meaning and lexical verbs or verb phrases, (2) event relations (tense markers, conjunctions, adverbs, perfect tense); (3) event schemas (lexical terms and phrases marking beginnings and endings). A…

  2. Adverse events in healthcare: learning from mistakes.

    PubMed

    Rafter, N; Hickey, A; Condell, S; Conroy, R; O'Connor, P; Vaughan, D; Williams, D

    2015-04-01

    Large national reviews of patient charts estimate that approximately 10% of hospital admissions are associated with an adverse event (defined as an injury resulting in prolonged hospitalization, disability or death, caused by healthcare management). Apart from having a significant impact on patient morbidity and mortality, adverse events also result in increased healthcare costs due to longer hospital stays. Furthermore, a substantial proportion of adverse events are preventable. Through identifying the nature and rate of adverse events, initiatives to improve care can be developed. A variety of methods exist to gather adverse event data both retrospectively and prospectively but these do not necessarily capture the same events and there is variability in the definition of an adverse event. For example, hospital incident reporting collects only a very small fraction of the adverse events found in retrospective chart reviews. Until there are systematic methods to identify adverse events, progress in patient safety cannot be reliably measured. This review aims to discuss the need for a safety culture that can learn from adverse events, describe ways to measure adverse events, and comment on why current adverse event monitoring is unable to demonstrate trends in patient safety.

  3. The Toarcian Oceanic Anoxic Event: a shallow-water perspective

    NASA Astrophysics Data System (ADS)

    Bodin, Stephane; Krencker, Francois-Nicolas; Kabiri, Lahcen; Immenhauser, Adrian

    2015-04-01

    The Toarcian ocean anoxic event (T-OAE, ca. 183 Ma) corresponds to a major perturbation of the carbon cycle as reflected by a marked decrease (2 to 7 per mil) in carbon-isotope ratios of various carbonate and organic matter phases. Severe environmental perturbations and biotic turnovers are accompanying the unfolding of the T-OAE, which is thought to be initiated by the activity of the Karoo-Ferrar large igneous province. Most of the studies dedicated to the T-OAE were however undertaken in mud-rich, deep-water setting, leaving vast uncertainties about its shallow-water expression and accompanying sea-level fluctuations. Here we present an extensive sedimentological dataset of the shallow-water record of the T-OAE within the Central High Atlas Basin of Morocco. The combination of ammonite and brachiopod biostratigraphy, together with carbon-isotope chemostratigraphy (on both carbonate and organic matter) allows a precise location of the T-OAE in the studied shallow-water sections. Thanks to well-exposed and thick successions, relative sea-level variations were reconstructed on a high-resolution scale, highlighting several important facts. Firstly, the T-OAE interval is preceded by a 50 meters-deep incised valley, observed within the uppermost Polymorphum ammonite zone. Similar observations have been reported from Euro-boreal basins and, together with published evidences of coeval occurrence of relatively cool seawater temperature and low atmospheric pCO2, we postulate that this forced regression is driven by glacio-eustasy. This points at the occurrence of a "cold snap" event just prior to the onset of the T-OAE. Secondly, the inception of the T-OAE is marked by the demise of the Lithiotid-dominated neritic carbonate factory, replaced by siliciclastic-dominated sedimentation during the T-OAE negative carbon isotope shift. Thirdly, an important progradation of oo-biodetritic shoal occurs during the negative carbon isotope plateau, underlying that the renewal of

  4. Algorithmic independence of initial condition and dynamical law in thermodynamics and causal inference

    NASA Astrophysics Data System (ADS)

    Janzing, Dominik; Chaves, Rafael; Schölkopf, Bernhard

    2016-09-01

    We postulate a principle stating that the initial condition of a physical system is typically algorithmically independent of the dynamical law. We discuss the implications of this principle and argue that they link thermodynamics and causal inference. On the one hand, they entail behavior that is similar to the usual arrow of time. On the other hand, they motivate a statistical asymmetry between cause and effect that has recently been postulated in the field of causal inference, namely, that the probability distribution {P}{{cause}} contains no information about the conditional distribution {P}{{effect}| {{cause}}} and vice versa, while {P}{{effect}} may contain information about {P}{{cause}| {{effect}}}.

  5. Trace elements in bivalves from the Rio Cruces, Chile, trace watershed evolution after a major earthquake and challenge a postulated chemical spill from a pulp plant

    NASA Astrophysics Data System (ADS)

    Risk, M.; Burchell, M.; Nairn, R.; Tubrett, M.; Forsterra, G.

    2009-05-01

    In May, 1960, the largest recorded earthquake in the history of the planet hit southern Chile, dropping part of the course of the Rio Cruces by 2m and creating an extensive wetland. The Brazilian Waterweed Egeria densa colonised the area, and became a primary food source for large populations of the Black-necked Swan, Cygnus melancoryphus. In 2004, a large pulp mill commenced operations upstream on the river. According to local reports, immediately after the opening of the plant, the weed died and the swans left. There was public outcry, and a search for a cause or a culprit. It was postulated that some sort of chemical spill from the plant caused the weed to die, resulting in departure of the swans. In 2008, we collected specimens of the bivalve Diplodon chilensis from several locations downstream from the Plant and towards the wetland to see if there was evidence of a chemical spill recorded in the shells. We prepared thin-sections of the shells to observe growth line development and patterns. Additionally, shell samples were analysed for stable oxygen isotopes and trace elements, using LA-ICP/MS. Based on annual growth lines, some of the bivalves were long-lived, with an age of more than 50 years. These individuals settled in the river shortly after the earthquake, and have lived there continuously ever since. Annual and sub-annual banding was clear, and the annual cyclicity of the major bands was verified with oxygen isotope analysis. There are no changes in growth corresponding to 2004. Trace element scans provided a wealth of information on the evolution of this earthquake-impacted wetland. Barium, Strontium and Manganese all showed strong annual cyclicity. From the analysis of older specimens, we interpret the high peaks of the Ba signal as reflecting soil erosion-Ba peaks are large immediately after the earthquake, then they diminish through time. Sr is likely a temperature signal, and Mn reflects runoff. Minor peaks in Cu, As and Pb probably reflect

  6. Episodes, events, and models

    PubMed Central

    Khemlani, Sangeet S.; Harrison, Anthony M.; Trafton, J. Gregory

    2015-01-01

    We describe a novel computational theory of how individuals segment perceptual information into representations of events. The theory is inspired by recent findings in the cognitive science and cognitive neuroscience of event segmentation. In line with recent theories, it holds that online event segmentation is automatic, and that event segmentation yields mental simulations of events. But it posits two novel principles as well: first, discrete episodic markers track perceptual and conceptual changes, and can be retrieved to construct event models. Second, the process of retrieving and reconstructing those episodic markers is constrained and prioritized. We describe a computational implementation of the theory, as well as a robotic extension of the theory that demonstrates the processes of online event segmentation and event model construction. The theory is the first unified computational account of event segmentation and temporal inference. We conclude by demonstrating now neuroimaging data can constrain and inspire the construction of process-level theories of human reasoning. PMID:26578934

  7. New constraints on oceanographic vs. seismic control on submarine landslide initiation: a geotechnical approach off Uruguay and northern Argentina

    NASA Astrophysics Data System (ADS)

    Ai, Fei; Strasser, Michael; Preu, Benedict; Hanebuth, Till J. J.; Krastel, Sebastian; Kopf, Achim

    2014-10-01

    Submarine landslides are common along the Uruguayan and Argentinean continental margin, but size, type and frequency of events differ significantly between distinct settings. Previous studies have proposed sedimentary and oceanographic processes as factors controlling slope instability, but also episodic earthquakes have been postulated as possible triggers. However, quantitative geotechnical slope stability evaluations for this region and, for that matter, elsewhere in the South Atlantic realm are lacking. This study quantitatively assesses continental slope stability for various scenarios including overpressure and earthquake activity, based on sedimentological and geotechnical analyses on three up to 36 m long cores collected on the Uruguayan slope, characterized by muddy contourite deposits and a locus of landslides (up to 2 km3), and in a canyon-dominated area on the northern Argentinean slope characterized by sandy contourite deposits. The results of shear and consolidation tests reveal that these distinct lithologies govern different stability conditions and failure modes. The slope sectors are stable under present-day conditions (factor of safety >5), implying that additional triggers would be required to initiate failure. In the canyon area, current-induced oversteepening of weaker sandy contourite deposits would account for frequent, small-scale slope instabilities. By contrast, static vs. seismic slope stability calculations reveal that a peak ground acceleration of at least 2 m/s2 would be required to cause failure of mechanically stronger muddy contourite deposits. This implies that, also along the western South Atlantic passive margin, submarine landslides on open gentle slopes require episodic large earthquakes as ultimate trigger, as previously postulated for other, northern hemisphere passive margins.

  8. Modeling and analysis framework for core damage propagation during flow-blockage-initiated accidents in the Advanced Neutron Source Reactor at Oak Ridge National Laboratory

    SciTech Connect

    Kim, S.H.; Taleyarkhan, R.P.; Navarro-Valenti, S.; Georgevich, V.

    1995-09-01

    This paper describes modeling and analysis to evaluate the extent of core damage during flow blockage events in the Advanced Neutron Source (ANS) reactor planned to be built at the Oak Ridge National Laboratory (ORNL). Damage propagation is postulated to occur from thermal conduction between damaged and undamaged plates due to direct thermal contact. Such direct thermal contact may occur because of fuel plate swelling during fission product vapor release or plate buckling. Complex phenomena of damage propagation were modeled using a one-dimensional heat transfer model. A scoping study was conducted to learn what parameters are important for core damage propagation, and to obtain initial estimates of core melt mass for addressing recriticality and steam explosion events. The study included investigating the effects of the plate contact area, the convective heat transfer coefficient, thermal conductivity upon fuel swelling, and the initial temperature of the plate being contacted by the damaged plate. Also, the side support plates were modeled to account for their effects on damage propagation. The results provide useful insights into how various uncertain parameters affect damage propagation.

  9. El Nino-like events during Miocene

    SciTech Connect

    Casey, R.E.; Nelson, C.O.; Weinheimer, A.L.; Oeth, P.A.; Swanson, R.J.

    1988-03-01

    El Nino-like events have been recorded from the Miocene laminated siliceous facies of the Monterey Formation. These El Nino-like Miocene events are compared to El Nino events recorded from Holocene varved sediments deposited within the anoxic Santa Barbara basin. Strong El Nino events can be recognized from Holocene Santa Barbara basin sediments by increases in radiolarian flux to the sea floor during those events. For the last 100-plus years, frequency of strong El Ninos has been on the order of one extremely strong event about every 100 years, and one easily recognizable event about every 18 years. Frequencies in the laminated (varved) Miocene range from about every 4-5 years to over 20 years. The higher frequencies occur within generally warm intervals and the lower frequencies within generally cold intervals. Perhaps the frequencies of these events may, in fact, be an important indicator in determining whether the intervals were cold or warm. Reconstructions of the paleo-California Current system during El Nino-like periods have been made for the west coast from the Gulf of California to northern California. Strong El Nino-like events occurred 5.5 and 8 Ma, and a strong anti-El Nino-like event occurred at about 6.5 Ma. Evidence from the 5.5 and 8 Ma events combined with other evidence suggests that modern El Ninos, similar to today's, were initiated at 5.5 Ma or earlier.

  10. Vaccine Adverse Events

    MedlinePlus

    ... Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products Vaccines, Blood & Biologics Home Vaccines, Blood & Biologics Safety & Availability ( ... Center for Biologics Evaluation & Research Vaccine Adverse Events Vaccine Adverse Events Share Tweet Linkedin Pin it More ...

  11. Event Logic Assistant (Elan)

    DTIC Science & Technology

    2008-07-14

    as a basis for Phase II research. 2 Background 2.1 Event logic 2.1.1 Event structures Intuitively, an event structure is an abstract algebraic ...Theoretical Computer Science, 149:257–298, 1995. [2] Uri Abraham. Models for Concurrency, volume 11 of Algebra , Logic and Applications Series. Gordon...the ordering of events in a distributed system. Comms. ACM, 21(7):558–65, 1978. [28] Leslie Lamport. Hybrid systems in TLA+. In Grossman , Nerode, Ravn

  12. Survey of Event Processing

    DTIC Science & Technology

    2007-12-01

    In the past decade, event processing technology has exploded from research at universities to a number of commercial products. In this paper, event... processing technology will be reviewed, starting with the motivations behind its development and ending with a look into the future of event processing

  13. New PHOBOS results on event-by-event fluctuations

    SciTech Connect

    Alver, B.; Ballintijn, M.; Busza, W.; Decowski, M. P.; Gulbrandsen, K.; Henderson, C.; Kane, J. L.; Kulinich, P.; Li, W.; Loizides, C.; Reed, C.; Roland, C.; Roland, G.; Rosenberg, L.; Sarin, P.; Stephans, G. S. F.; Vale, C.; Nieuwenhuizen, G. J. van; Vaurynovich, S. S.; Verdier, R.

    2006-04-11

    We present new results from the PHOBOS experiment at RHIC on event-by-event fluctuations of particle multiplicities and angular distributions in nucleus-nucleus collisions at RHIC. Our data for Au+Au collisions at {radical}(s{sub NN}) = 200 GeV show that at a level of 10-4 or less, no rare, large-amplitude fluctuations in the total multiplicity distributions or the shape of the pseudorapidity distributions are observed. We however find significant short-range multiplicity correlations in these data, that can be described as particle production in clusters. In Cu+Cu collisions, we observe large final-state azimuthal anisotropies {nu}2. A common scaling behavior for Cu+Cu and Au+Au for these anisotropies emerges when fluctuations in the initial state geometry are taken into account.

  14. The Chelyabinsk Airburst Event

    NASA Astrophysics Data System (ADS)

    Boslough, Mark

    2013-10-01

    On Feb. 15, 2013, an asteroid exploded about 40 km from the Russian city of Chelyabinsk. Its proximity led to many injuries and widespread blast damage, but also yielded a plethora of data, providing means to determine the projectile size and entry parameters, and develop a self-consistent model. We will present results of the first physics simulations to be initialized with accurate energy deposition derived from observations. The best estimate of the explosive yield is 400-500 kilotons, making Chelyabinsk the most powerful such event observed since Tunguska (3-5 megatons). Analysis of video combined with subsequent on-site stellar calibrations enable precise estimates of entry velocity (19 km/s), angle (17° elevation) and altitude of peak brightness (29 km). This implies a pre-entry diameter of ~20 m and mass of ~1200 tonnes. Satellite sensors recorded the emission peak at 03:20:33 UT, with a total radiated energy of 3.75×1014 J 90 kilotons). A typical bolide luminous efficiency of 20% implies a total energy of ~450 kilotons, consistent with infrasound and other observations. The maximum radiant intensity was 2.7×1013 W/ster, corresponding to a magnitude of -28. The shallow entry angle led to a long bolide duration (16.5 s) and energy was deposited over 100s of km leading to an extended, near-horizontal, linear explosion. The blast was distributed over a large area, and was much weaker than for a steep entry and a more concentrated explosion closer to the surface. The orientation also led to different phenomena than expected for a more vertical entry. There was no ballistic plume as observed from SL9 impacts (45°) or calculated for Tunguska 35°). Instead, buoyant instabilities grew into mushroom clouds and bifurcated the trail into two contra-rotating vortices. Chelyabinsk and Tunguska are “once-per-century” and “once-per-millennium” events, respectively. These outliers imply that the frequency of large airbursts is underestimated. Models also

  15. The Arithmetic of events and a new theory of Gravitation

    NASA Astrophysics Data System (ADS)

    Abbasi, Malek

    2012-04-01

    Of fundamental importance in physics is the concept of event. This study tries; first, to provide a mathematical background showing how must deal with these events and based on what laws the watches, another important concept used frequently in this research, record them. Armed, then, with this mathematical background, the Gravitational Clouds Theory, a novel theory of gravitation concerning the role of the matter and energy in the universe, is proposed. This completely new theory leads to miscellanies results some of which are: the second Einstein's postulate; the well known identity E = mc2; the time-dilation phenomenon and Fitzgerald-Lorentz contraction. This theory will also explain why indeed we never feel the speed of the Earth, what is the origin of Dark matter-energy and many other extraordinary results associated with cosmology.

  16. The Arithmetic of Events and a New Theory of Gravitation

    NASA Astrophysics Data System (ADS)

    Abbasi, Malek

    2012-10-01

    Of fundamental importance in physics is the concept of event. This study tries, first, to provide a mathematical background showing how must deal with these events and based on what laws the watches, another important concept used frequently in this research, record them. Armed, then, with this mathematical background, the Gravitational Clouds Theory, a novel theory of gravitation concerning the role of the matter and energy in the universe, is proposed. This completely new theory leads to miscellanies results some of which are: the second Einstein's postulate; the well known identity E = mc2; the time-dilation phenomenon and Fitzgerald-Lorentz contraction. This theory will also explain why indeed we never feel the speed of the Earth, what is the origin of Dark matter-energy and many other extraordinary results associated with cosmology.

  17. Play Initiating Behaviors and Responses in Red Colobus Monkeys

    ERIC Educational Resources Information Center

    Worch, Eric A.

    2012-01-01

    Red colobus monkeys are playful primates, making them an important species in which to study animal play. The author examines play behaviors and responses in the species for its play initiation events, age differences in initiating frequency and initiating behavior, and the types of social play that result from specific initiating behaviors. Out…

  18. Charge-dependent correlations from event-by-event anomalous hydrodynamics

    NASA Astrophysics Data System (ADS)

    Hirono, Yuji; Hirano, Tetsufumi; Kharzeev, Dmitri E.

    2016-12-01

    We report on our recent attempt of quantitative modeling of the Chiral Magnetic Effect (CME) in heavy-ion collisions. We perform 3+1 dimensional anomalous hydrodynamic simulations on an event-by-event basis, with constitutive equations that contain the anomaly-induced effects. We also develop a model of the initial condition for the axial charge density that captures the statistical nature of random chirality imbalances created by the color flux tubes. Basing on the event-by-event hydrodynamic simulations for hundreds of thousands of collisions, we calculate the correlation functions that are measured in experiments, and discuss how the anomalous transport affects these observables.

  19. Dialogue on private events

    PubMed Central

    Palmer, David C.; Eshleman, John; Brandon, Paul; Layng, T. V. Joe; McDonough, Christopher; Michael, Jack; Schoneberger, Ted; Stemmer, Nathan; Weitzman, Ray; Normand, Matthew

    2004-01-01

    In the fall of 2003, the authors corresponded on the topic of private events on the listserv of the Verbal Behavior Special Interest Group. Extracts from that correspondence raised questions about the role of response amplitude in determining units of analysis, whether private events can be investigated directly, and whether covert behavior differs from other behavior except in amplitude. Most participants took a cautious stance, noting not only conceptual pitfalls and empirical difficulties in the study of private events, but doubting the value of interpretive exercises about them. Others argued that despite such obstacles, in domains where experimental analyses cannot be done, interpretation of private events in the light of laboratory principles is the best that science can offer. One participant suggested that the notion that private events can be behavioral in nature be abandoned entirely; as an alternative, the phenomena should be reinterpreted only as physiological events. PMID:22477293

  20. Forward flux sampling for rare event simulations.

    PubMed

    Allen, Rosalind J; Valeriani, Chantal; Rein Ten Wolde, Pieter

    2009-11-18

    Rare events are ubiquitous in many different fields, yet they are notoriously difficult to simulate because few, if any, events are observed in a conventional simulation run. Over the past several decades, specialized simulation methods have been developed to overcome this problem. We review one recently developed class of such methods, known as forward flux sampling. Forward flux sampling uses a series of interfaces between the initial and final states to calculate rate constants and generate transition paths for rare events in equilibrium or nonequilibrium systems with stochastic dynamics. This review draws together a number of recent advances, summarizes several applications of the method and highlights challenges that remain to be overcome.

  1. Landscape of international event-based biosurveillance.

    PubMed

    Hartley, Dm; Nelson, Np; Walters, R; Arthur, R; Yangarber, R; Madoff, L; Linge, Jp; Mawudeku, A; Collier, N; Brownstein, Js; Thinus, G; Lightfoot, N

    2010-01-01

    Event-based biosurveillance is a scientific discipline in which diverse sources of data, many of which are available from the Internet, are characterized prospectively to provide information on infectious disease events. Biosurveillance complements traditional public health surveillance to provide both early warning of infectious disease events and situational awareness. The Global Health Security Action Group of the Global Health Security Initiative is developing a biosurveillance capability that integrates and leverages component systems from member nations. This work discusses these biosurveillance systems and identifies needed future studies.

  2. Landscape of international event-based biosurveillance

    PubMed Central

    Hartley, DM; Nelson, NP; Walters, R; Arthur, R; Yangarber, R; Madoff, L; Linge, JP; Mawudeku, A; Collier, N; Brownstein, JS; Thinus, G; Lightfoot, N

    2010-01-01

    Event-based biosurveillance is a scientific discipline in which diverse sources of data, many of which are available from the Internet, are characterized prospectively to provide information on infectious disease events. Biosurveillance complements traditional public health surveillance to provide both early warning of infectious disease events and situational awareness. The Global Health Security Action Group of the Global Health Security Initiative is developing a biosurveillance capability that integrates and leverages component systems from member nations. This work discusses these biosurveillance systems and identifies needed future studies. PMID:22460393

  3. Atmospheric transmission of North Atlantic Heinrich events

    USGS Publications Warehouse

    Hostetler, S.W.; Clark, P.U.; Bartlein, P.J.; Mix, A.C.; Pisias, N.J.

    1999-01-01

    We model the response of the climate system during Heinrich event 2 (H2) by employing an atmospheric general circulation model, using boundary conditions based on the concept of a "canonical" Heinrich event. The canonical event is initialized with a full-height Laurentide ice sheet (LIS) and CLIMAP sea surface temperatures (SSTs), followed by lowering of the LIS, then warming of North Atlantic SSTs. Our modeled temperature and wind fields exhibit spatially variable responses over the Northern Hemisphere at each stage of the H2 event. In some regions the climatic responses are additive, whereas in other regions they cancel or are of opposite sign, suggesting that Heinrich event climatic variations may have left complex signatures in geologic records. We find variations in the tropical water balance and the mass balance of ice sheets, and implications for variations in terrestrial methane production from the contraction of northern permafrost regions and the expansion of tropical wetlands. Copyright 1999 by the American Geophysical Union.

  4. The end-triassic mass extinction event

    NASA Technical Reports Server (NTRS)

    Hallam, A.

    1988-01-01

    The end-Triassic is the least studied of the five major episodes of mass extinction recognized in the Phanerozoic, and the Triassic-Jurassic boundary is not precisely defined in most parts of the world, with a paucity of good marine sections and an insufficiency of biostratigraphically valuable fossils. Despite these limitations it is clear that there was a significant episode of mass extinction, affecting many groups, in the Late Norian and the existing facts are consistent with it having taken place at the very end of the period. The best record globally comes from marine strata. There was an almost complete turnover of ammonites across the T-J boundary, with perhaps no more than one genus surviving. About half the bivalve genera and most of the species went extinct, as did many archaeogastropods. Many Paleozoic-dominant brachiopods also disappeared, as did the last of the conodonts. There was a major collapse and disappearance of the Alpine calcareous sponge. Among terrestrial biota, a significant extinction event involving tetrapods was recognized. With regard to possible environmental events that may be postulated to account for the extinctions, there is no evidence of any significant global change of climate at this time. The existence of the large Manicouagan crater in Quebec, dated as about late or end-Triassic, has led to the suggestion that an impact event might be implicated, but so far despite intensive search no unequivocal iridium anomaly or shocked quartz was discovered. On the other hand there is strong evidence for significant marine regression in many parts of the world. It is proposed therefore that the likeliest cause of the marine extinctions is severe reduction in habitat area caused either by regression of epicontinental seas, subsequent widespread anoxia during the succeeding transgression, or a combination of the two.

  5. Event-by-Event Simulation of Induced Fission

    SciTech Connect

    Vogt, R; Randrup, J

    2007-12-13

    We are developing a novel code that treats induced fission by statistical (or Monte-Carlo) simulation of individual decay chains. After its initial excitation, the fissionable compound nucleus may either deexcite by evaporation or undergo binary fission into a large number of fission channels each with different energetics involving both energy dissipation and deformed scission prefragments. After separation and Coulomb acceleration, each fission fragment undergoes a succession of individual (neutron) evaporations, leading to two bound but still excited fission products (that may further decay electromagnetically and, ultimately, weakly), as well as typically several neutrons. (The inclusion of other possible ejectiles is planned.) This kind of approach makes it possible to study more detailed observables than could be addressed with previous treatments which have tended to focus on average quantities. In particular, any type of correlation observable can readily be extracted from a generated set of events. With a view towards making the code practically useful in a variety of applications, emphasis is being put on making it numerically efficient so that large event samples can be generated quickly. In its present form, the code can generate one million full events in about 12 seconds on a MacBook laptop computer. The development of this qualitatively new tool is still at an early stage and quantitative reproduction of existing data should not be expected until a number of detailed refinement have been implemented.

  6. Event-by-Event Simulation of Induced Fission

    SciTech Connect

    Vogt, Ramona; Randrup, Joergen

    2008-04-17

    We are developing a novel code that treats induced fission by statistical (or Monte-Carlo) simulation of individual decay chains. After its initial excitation, the fissionable compound nucleus may either de-excite by evaporation or undergo binary fission into a large number of fission channels each with different energetics involving both energy dissipation and deformed scission pre-fragments. After separation and Coulomb acceleration, each fission fragment undergoes a succession of individual (neutron) evaporations, leading to two bound but still excited fission products (that may further decay electromagnetically and, ultimately, weakly), as well as typically several neutrons. (The inclusion of other possible ejectiles is planned.) This kind of approach makes it possible to study more detailed observables than could be addressed with previous treatments which have tended to focus on average quantities. In particular, any type of correlation observable can readily be extracted from a generated set of events. With a view towards making the code practically useful in a variety of applications, emphasis is being put on making it numerically efficient so that large event samples can be generated quickly. In its present form, the code can generate one million full events in about 12 seconds on a MacBook laptop computer. The development of this qualitatively new tool is still at an early stage and quantitative reproduction of existing data should not be expected until a number of detailed refinement have been implemented.

  7. Rapid (10-yr) recovery of terrestrial productivity in a simulation study of the terminal Cretaceous impact event

    NASA Astrophysics Data System (ADS)

    Lomax, Barry; Beerling, David; Upchurch, Garland; Otto-Bliesner, Bette

    2001-10-01

    Investigations of short-term (up to 10 3 yr) environmental change across the Cretaceous-Tertiary boundary provide evidence for reduced temperatures, consistent with the injection of debris and sulphate aerosols into the upper atmosphere by a large impact event. Concomitant with this was a postulated massive addition of CO 2 to the atmospheric carbon reservoir by impact vaporisation of the Chicxulub carbonate platform. Taken together, a high CO 2 but low irradiance environment would have created unusual conditions for the operation of the terrestrial biosphere. Here, we have evaluated this environmental influence on terrestrial ecosystems using a process-based dynamic global vegetation model forced with post-impact global climates, derived by modification of the GENESIS atmospheric climate model simulation for the latest Cretaceous. Our results suggest that terrestrial primary productivity initially collapsed and then recovered to pre-impact levels within a decade. Global terrestrial carbon storage in vegetation biomass exhibited a similar collapse but complete recovery took place on a 60-80 yr timescale. The recovery of both terrestrial net primary productivity and vegetation biomass was largely mediated by the high CO 2 concentration stimulating ecosystem photosynthetic productivity in the warm low latitudes. An apparently rapid recovery of terrestrial ecosystem function stands in marked contrast to the situation for the marine realm, where the organic carbon flux to the deep ocean was suppressed for up to 3 million years.

  8. Features, Events, and Processes: Disruptive Events

    SciTech Connect

    J. King

    2004-03-31

    The primary purpose of this analysis is to evaluate seismic- and igneous-related features, events, and processes (FEPs). These FEPs represent areas of natural system processes that have the potential to produce disruptive events (DE) that could impact repository performance and are related to the geologic processes of tectonism, structural deformation, seismicity, and igneous activity. Collectively, they are referred to as the DE FEPs. This evaluation determines which of the DE FEPs are excluded from modeling used to support the total system performance assessment for license application (TSPA-LA). The evaluation is based on the data and results presented in supporting analysis reports, model reports, technical information, or corroborative documents that are cited in the individual FEP discussions in Section 6.2 of this analysis report.

  9. Event-by-Event Fission with FREYA

    SciTech Connect

    Randrup, J; Vogt, R

    2010-11-09

    The recently developed code FREYA (Fission Reaction Event Yield Algorithm) generates large samples of complete fission events, consisting of two receding product nuclei as well as a number of neutrons and photons, all with complete kinematic information. Thus it is possible to calculate arbitrary correlation observables whose behavior may provide unique insight into the fission process. The presentation first discusses the present status of FREYA, which has now been extended up to energies where pre-equilibrium emission becomes significant and one or more neutrons may be emitted prior to fission. Concentrating on {sup 239}Pu(n,f), we discuss the neutron multiplicity correlations, the dependence of the neutron energy spectrum on the neutron multiplicity, and the relationship between the fragment kinetic energy and the number of neutrons and their energies. We also briefly suggest novel fission observables that could be measured with modern detectors.

  10. Features, Events, and Processes: Disruptive Events

    SciTech Connect

    P. Sanchez

    2004-11-08

    The purpose of this analysis report is to evaluate and document the inclusion or exclusion of the disruptive events features, events, and processes (FEPs) with respect to modeling used to support the total system performance assessment for license application (TSPA-LA). A screening decision, either ''Included'' or ''Excluded,'' is given for each FEP, along with the technical basis for screening decisions. This information is required by the U.S. Nuclear Regulatory Commission (NRC) at 10 CFR 63.114 (d), (e), and (f) [DIRS 156605]. The FEPs addressed in this report deal with both seismic and igneous disruptive events, such as fault displacements through the repository and an igneous intrusion into the repository. For included FEPs, this analysis summarizes the implementation of the FEP in TSPA-LA (i.e., how the FEP is included). For excluded FEPs, this analysis provides the technical basis for exclusion from TSPA-LA (i.e., why the FEP is excluded). Previous versions of this report were developed to support the total system performance assessments (TSPA) for various prior repository designs. This revision addresses the repository design for the license application (LA).

  11. Committed Sport Event Volunteers

    ERIC Educational Resources Information Center

    Han, Keunsu; Quarterman, Jerome; Strigas, Ethan; Ha, Jaehyun; Lee, Seungbum

    2013-01-01

    The purpose of this study was to investigate the relationships among selected demographic characteristics (income, education and age), motivation and commitment of volunteers at a sporting event. Three-hundred and five questionnaires were collected from volunteers in a marathon event and analyzed using structural equation modeling (SEM). Based on…

  12. Activating Event Knowledge

    ERIC Educational Resources Information Center

    Hare, Mary; Jones, Michael; Thomson, Caroline; Kelly, Sarah; McRae, Ken

    2009-01-01

    An increasing number of results in sentence and discourse processing demonstrate that comprehension relies on rich pragmatic knowledge about real-world events, and that incoming words incrementally activate such knowledge. If so, then even outside of any larger context, nouns should activate knowledge of the generalized events that they denote or…

  13. Improving Seismic Event Characterisation

    DTIC Science & Technology

    1996-07-22

    according to age, four regions of low volcanic and earthquake activity, in addition to a region termed tectonic continent where activity is high. We... Queensland . 0 * il-’gme 7.2 shows tire locations of events whichl have been used. Ti1𔃼 events l:cI , ’"re,: hcc.eI with a inininmm of fcu; iecords

  14. Contrasting Large Solar Events

    NASA Astrophysics Data System (ADS)

    Lanzerotti, Louis J.

    2010-10-01

    After an unusually long solar minimum, solar cycle 24 is slowly beginning. A large coronal mass ejection (CME) from sunspot 1092 occurred on 1 August 2010, with effects reaching Earth on 3 August and 4 August, nearly 38 years to the day after the huge solar event of 4 August 1972. The prior event, which those of us engaged in space research at the time remember well, recorded some of the highest intensities of solar particles and rapid changes of the geomagnetic field measured to date. What can we learn from the comparisons of these two events, other than their essentially coincident dates? One lesson I took away from reading press coverage and Web reports of the August 2010 event is that the scientific community and the press are much more aware than they were nearly 4 decades ago that solar events can wreak havoc on space-based technologies.

  15. PRELIMINARY SELECTION OF MGR DESIGN BASIS EVENTS

    SciTech Connect

    J.A. Kappes

    1999-09-16

    The purpose of this analysis is to identify the preliminary design basis events (DBEs) for consideration in the design of the Monitored Geologic Repository (MGR). For external events and natural phenomena (e.g., earthquake), the objective is to identify those initiating events that the MGR will be designed to withstand. Design criteria will ensure that radiological release scenarios resulting from these initiating events are beyond design basis (i.e., have a scenario frequency less than once per million years). For internal (i.e., human-induced and random equipment failures) events, the objective is to identify credible event sequences that result in bounding radiological releases. These sequences will be used to establish the design basis criteria for MGR structures, systems, and components (SSCs) design basis criteria in order to prevent or mitigate radiological releases. The safety strategy presented in this analysis for preventing or mitigating DBEs is based on the preclosure safety strategy outlined in ''Strategy to Mitigate Preclosure Offsite Exposure'' (CRWMS M&O 1998f). DBE analysis is necessary to provide feedback and requirements to the design process, and also to demonstrate compliance with proposed 10 CFR 63 (Dyer 1999b) requirements. DBE analysis is also required to identify and classify the SSCs that are important to safety (ITS).

  16. The Plus 50 Initiative Evaluation: Initiative Impact

    ERIC Educational Resources Information Center

    American Association of Community Colleges (NJ1), 2012

    2012-01-01

    The American Association of Community Colleges (AACC), with funding from The Atlantic Philanthropies, created the Plus 50 Initiative (2008-2012). This initiative was designed to build the capacity of community colleges nationwide to develop programming that engages the plus 50 learner. This report contains: (1) An overview of the Plus 50…

  17. Spatial remapping of tactile events

    PubMed Central

    Azañón, Elena

    2008-01-01

    During the apparently mindless act of localizing a tactile sensation, our brain must realign its initial spatial representation (somatotopicaly arranged) according to current body posture (arising from proprioception, vision and even audition).1–3 We have recently illustrated4 the temporal course of this recoding of tactile space from somatotopic to external coordinates using a crossmodal cueing psychophysical paradigm5,6 where behavioral reactions to visual targets are evaluated as a function of the location of irrelevant tactile cues. We found that the tactile events are initially represented in terms of a fleeting, non-conscious but nevertheless behaviorally consequential somatotopic format, which is quickly replaced by the representations referred to external spatial locations that prevail in our everyday experience. In this addendum, we test the intuition that frequent changes in body posture will make it harder to update the spatial remapping system and thus, produce stronger psychophysical correlates of the initial somatotopically-based spatial representations. Contrary to this expectation, however, we found no evidence for a modulation when preventing adaptation to a body posture. PMID:19704788

  18. CCG - News & Events

    Cancer.gov

    NCI's Center for Cancer Genomics (CCG) has been widely recognized for its research efforts to facilitiate advances in cancer genomic research and improve patient outcomes. Find the latest news about and events featuring CCG.

  19. Special Event Production.

    ERIC Educational Resources Information Center

    Currents, 2002

    2002-01-01

    Offers a descriptive table of software that helps higher education institutions orchestrate events. Information includes vendor, contact, software, price, database engine/server platform, specific features, and client type. (EV)

  20. Historical Radiological Event Monitoring

    EPA Pesticide Factsheets

    During and after radiological events EPA's RadNet monitors the environment for radiation. EPA monitored environmental radiation levels during and after Chernobyl, Fukushima and other international and domestic radiological incidents.

  1. "Universe" event at AIMS

    NASA Astrophysics Data System (ADS)

    2008-06-01

    Report of event of 11 May 2008 held at the African Institute of Mathematical Sciences (Muizenberg, Cape), with speakers Michael Griffin (Administrator of NASA), Stephen Hawking (Cambridge), David Gross (Kavli Institute, Santa Barbara) and George Smoot (Berkeley).

  2. QCD (&) event generators

    SciTech Connect

    Skands, Peter Z.; /Fermilab

    2005-07-01

    Recent developments in QCD phenomenology have spurred on several improved approaches to Monte Carlo event generation, relative to the post-LEP state of the art. In this brief review, the emphasis is placed on approaches for (1) consistently merging fixed-order matrix element calculations with parton shower descriptions of QCD radiation, (2) improving the parton shower algorithms themselves, and (3) improving the description of the underlying event in hadron collisions.

  3. Small Business Procurement Event

    DTIC Science & Technology

    2014-08-13

    Small Business Procurement Event 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK...distribution unlimited 13. SUPPLEMENTARY NOTES NDIA 27th Navy Gold Coast Small Business Procurement Event , 12-13 Aug 2014, San Diego, CA. 14. ABSTRACT...18 Target the Small Business Accessible Market within the Department of the Navy $77.8B Department of the Navy Total SB Eligible Spend

  4. Activating event knowledge.

    PubMed

    Hare, Mary; Jones, Michael; Thomson, Caroline; Kelly, Sarah; McRae, Ken

    2009-05-01

    An increasing number of results in sentence and discourse processing demonstrate that comprehension relies on rich pragmatic knowledge about real-world events, and that incoming words incrementally activate such knowledge. If so, then even outside of any larger context, nouns should activate knowledge of the generalized events that they denote or typically play a role in. We used short stimulus onset asynchrony priming to demonstrate that (1) event nouns prime people (sale-shopper) and objects (trip-luggage) commonly found at those events; (2) location nouns prime people/animals (hospital-doctor) and objects (barn-hay) commonly found at those locations; and (3) instrument nouns prime things on which those instruments are commonly used (key-door), but not the types of people who tend to use them (hose-gardener). The priming effects are not due to normative word association. On our account, facilitation results from event knowledge relating primes and targets. This has much in common with computational models like LSA or BEAGLE in which one word primes another if they frequently occur in similar contexts. LSA predicts priming for all six experiments, whereas BEAGLE correctly predicted that priming should not occur for the instrument-people relation but should occur for the other five. We conclude that event-based relations are encoded in semantic memory and computed as part of word meaning, and have a strong influence on language comprehension.

  5. Seismic event classification system

    DOEpatents

    Dowla, Farid U.; Jarpe, Stephen P.; Maurer, William

    1994-01-01

    In the computer interpretation of seismic data, the critical first step is to identify the general class of an unknown event. For example, the classification might be: teleseismic, regional, local, vehicular, or noise. Self-organizing neural networks (SONNs) can be used for classifying such events. Both Kohonen and Adaptive Resonance Theory (ART) SONNs are useful for this purpose. Given the detection of a seismic event and the corresponding signal, computation is made of: the time-frequency distribution, its binary representation, and finally a shift-invariant representation, which is the magnitude of the two-dimensional Fourier transform (2-D FFT) of the binary time-frequency distribution. This pre-processed input is fed into the SONNs. These neural networks are able to group events that look similar. The ART SONN has an advantage in classifying the event because the types of cluster groups do not need to be pre-defined. The results from the SONNs together with an expert seismologist's classification are then used to derive event classification probabilities.

  6. Seismic event classification system

    DOEpatents

    Dowla, F.U.; Jarpe, S.P.; Maurer, W.

    1994-12-13

    In the computer interpretation of seismic data, the critical first step is to identify the general class of an unknown event. For example, the classification might be: teleseismic, regional, local, vehicular, or noise. Self-organizing neural networks (SONNs) can be used for classifying such events. Both Kohonen and Adaptive Resonance Theory (ART) SONNs are useful for this purpose. Given the detection of a seismic event and the corresponding signal, computation is made of: the time-frequency distribution, its binary representation, and finally a shift-invariant representation, which is the magnitude of the two-dimensional Fourier transform (2-D FFT) of the binary time-frequency distribution. This pre-processed input is fed into the SONNs. These neural networks are able to group events that look similar. The ART SONN has an advantage in classifying the event because the types of cluster groups do not need to be pre-defined. The results from the SONNs together with an expert seismologist's classification are then used to derive event classification probabilities. 21 figures.

  7. Initialized Fractional Calculus

    NASA Technical Reports Server (NTRS)

    Lorenzo, Carl F.; Hartley, Tom T.

    2000-01-01

    This paper demonstrates the need for a nonconstant initialization for the fractional calculus and establishes a basic definition set for the initialized fractional differintegral. This definition set allows the formalization of an initialized fractional calculus. Two basis calculi are considered; the Riemann-Liouville and the Grunwald fractional calculi. Two forms of initialization, terminal and side are developed.

  8. Identification of the "minimal triangle" and other common event-to-event transitions in conflict and containment incidents.

    PubMed

    Bowers, Len; James, Karen; Quirk, Alan; Wright, Steve; Williams, Hilary; Stewart, Duncan

    2013-07-01

    Although individual conflict and containment events among acute psychiatric inpatients have been studied in some detail, the relationship of these events to each other has not. In particular, little is known about the temporal order of events for individual patients. This study aimed to identify the most common pathways from event to event. A sample of 522 patients was recruited from 84 acute psychiatric wards in 31 hospital locations in London and the surrounding areas during 2009-2010. Data on the order of conflict and containment events were collected for the first two weeks of admission from patients' case notes. Event-to-event transitions were tabulated and depicted diagrammatically. Event types were tested for their most common temporal placing in sequences of events. Most conflict and containment occurs within and between events of the minimal triangle (verbal aggression, de-escalation, and PRN medication), and the majority of these event sequences conclude in no further events; a minority transition to other, more severe, events. Verbal abuse and medication refusal were more likely to start sequences of disturbed behaviour. Training in the prevention and management of violence needs to acknowledge that a gradual escalation of patient behaviour does not always occur. Verbal aggression is a critical initiator of conflict events, and requires more detailed and sustained research on optimal management and prevention strategies. Similar research is required into medication refusal by inpatients.

  9. Comparison of the 26 May 2012 SEP Event with the 3 November 2011 SEP Event

    NASA Astrophysics Data System (ADS)

    Makela, P. A.; Gopalswamy, N.; Thakur, N.; Xie, H.

    2015-12-01

    We compare the solar and interplanetary events associated with two large solar energetic particle (SEP) events on 26 May 2012 and 3 November 2011. Both SEP events were detected at three longitudinally widely separated locations by STEREO A and B spacecraft (more than 100 deg away from Earth) and the Wind and SOHO spacecraft near Earth. In Earth view, the November 2011 eruption occurred far behind the east limb at N09E154, whereas the May 2012 eruption occurred closer to the west limb at N15W121, suggesting that SEPs accelerated during the 2012 event might have easier access to Earth. Even though the 2012 event was more intense in the GOES >10 MeV proton channel (peak intensity 14 pfu) than the 2011 event (peak intensity 4 pfu), we find that the latter event was more intense at higher energies (> 40 MeV). Also, the initial rise at lower energies was slightly faster for the 2011 event as measured by SOHO/ERNE. In addition, the CME associated with the May 2012 event was faster with an estimated space speed of ~2029 km/s than that in the November 2011 event (1188 km/s). STEREO/EUVI images of the associated post-eruption arcades (PEAs) indicate that their orientations were different: the PEA of the May 2012 event had a high inclination (north-south), while the inclination of the PEA of the 2011 event was more moderate. Differences in the flux rope orientation may also have effect on the longitudinal extent of the SEP events. These observations suggest that the dependence of solar proton intensities on the observer's longitudinal distance from the solar source is more complex than traditionally assumed.

  10. Concepts of event-by-event analysis

    SciTech Connect

    Stroebele, H.

    1995-07-15

    The particles observed in the final state of nuclear collisions can be divided into two classes: those which are susceptible to strong interactions and those which are not, like leptons and the photon. The bulk properties of the {open_quotes}matter{close_quotes} in the reaction zone may be read-off the kinematical characteristics of the particles observable in the final state. These characteristics are strongly dependent on the last interaction these particles have undergone. In a densly populated reaction zone strongly interacting particles will experience many collisions after they have been formed and before they emerge into the asymptotic final state. For the particles which are not sensitive to strong interactions their formation is also their last interaction. Thus photons and leptons probe the period during which they are produced whereas hadrons reflect the so called freeze-out processes, which occur during the late stage in the evolution of the reaction when the population density becomes small and the mean free paths long. The disadvantage of the leptons and photons is their small production cross section; they cannot be used in an analysis of the characteristics of individual collision events, because the number of particles produced per event is too small. The hadrons, on the other hand, stem from the freeze-out period. Information from earlier periods requires multiparticle observables in the most general sense. It is one of the challenges of present day high energy nuclear physics to establish and understand global observables which differentiate between mere hadronic scenarios, i.e superposition of hadronic interactions, and the formation of a partonic (short duration) steady state which can be considered a new state of matter, the Quark-Gluon Plasma.

  11. Particle transport in 3 He-rich events: wave-particle interactions and particle anisotropy measurements

    NASA Astrophysics Data System (ADS)

    Tsurutani, B. T.; Zhang, L. D.; Mason, G. L.; Lakhina, G. S.; Hada, T.; Arballo, J. K.; Zwickl, R. D.

    2002-04-01

    Energetic particles and MHD waves are studied using simultaneous ISEE-3 data to investigate particle propagation and scattering between the source near the Sun and 1 AU. 3 He-rich events are of particular interest because they are typically low intensity "scatter-free" events. The largest solar proton events are of interest because they have been postulated to generate their own waves through beam instabilities. For 3 He-rich events, simultaneous interplanetary magnetic spectra are measured. The intensity of the interplanetary "fossil" turbulence through which the particles have traversed is found to be at the "quiet" to "intermediate" level of IMF activity. Pitch angle scattering rates and the corresponding particle mean free paths l

  12. What is satisfying about satisfying events? Testing 10 candidate psychological needs.

    PubMed

    Sheldon, K M; Elliot, A J; Kim, Y; Kasser, T

    2001-02-01

    Three studies compared 10 candidate psychological needs in an attempt to determine which are truly most fundamental for humans. Participants described "most satisfying events" within their lives and then rated the salience of each of the 10 candidate needs within these events. Supporting self-determination theory postulates (Ryan & Deci, 2000)--autonomy, competence, and relatedness, were consistently among the top 4 needs, in terms of both their salience and their association with event-related affect. Self-esteem was also important, whereas self-actualization or meaning, physical thriving, popularity or influence, and money-luxury were less important. This basic pattern emerged within three different time frames and within both U.S. and South Korean samples and also within a final study that asked, "What's unsatisfying about unsatisfying events?" Implications for hierarchical theories of needs are discussed.

  13. Initiation of a coronal transient

    SciTech Connect

    Low, B.C.; Munro, R.H.; Fisher, R.R.

    1982-03-01

    This paper analyzes the coronal transient/eruptive prominence event of 1980 August 5 observed by the Mauna Loa experiment system. This event yielded data on the early development of the transient in the low corona between 1.2 R/sub sun/ and 2.2 R/sub sun/, information which was not available when earlier attempts were made to explain transient phenomena. The transient's initial appearance in the form of a rising density-depleted structure, prior to the eruption of the associated prominence, can be explained as an effect of magnetic buoyancy. The data indicate that this transient has a density depletion of 17% to 33% relative to an undisturbed corona which is approximately isothermal with a temperature of 1.5 x 10/sup 6/ K and a coronal density of 1.0 x 10/sup 9/ cm/sup -3/ at the base of the corona. The height versus base length relationship of the evolving transient resembles, remarkably well, the theoretical predictions obtained from a quasi-static model of a margnetically buoyant loop system. By matching this relationship with the theoretical model, we estimate the magnetic field at the base of the transient to be between 2 and 3 gauss. It is also shown that the initial, nearly constant speed of the top of the transient, 80 +- 20 km s/sup -1/, is consistent with a theoretical estimate calculated from the quasi-static model. These results suggest that some transients are not initiated impulsively, the initial stage of the development being driven by a quasi-static response to a slow change in magnetic field conditions at the base of the corona.

  14. Solar extreme events

    NASA Astrophysics Data System (ADS)

    Hudson, Hugh S.

    2015-08-01

    Solar flares and CMEs have a broad range of magnitudes. This review discusses the possibility of “extreme events,” defined as those with magnitudes greater than have been seen in the existing historical record. For most quantitative measures, this direct information does not extend more than a century and a half into the recent past. The magnitude distributions (occurrence frequencies) of solar events (flares/CMEs) typically decrease with the parameter measured or inferred (peak flux, mass, energy etc. Flare radiation fluxes tend to follow a power law slightly flatter than S-2, where S represents a peak flux; solar particle events (SPEs) follow a still flatter power law up to a limiting magnitude, and then appear to roll over to a steeper distribution, which may take an exponential form or follow a broken power law. This inference comes from the terrestrial 14C record and from the depth dependence of various radioisotope proxies in the lunar regolith and in meteorites. Recently major new observational results have impacted our use of the relatively limited historical record in new ways: the detection of actual events in the 14C tree-ring records, and the systematic observations of flares and “superflares” by the Kepler spacecraft. I discuss how these new findings may affect our understanding of the distribution function expected for extreme solar events.

  15. RETRIEVAL EVENTS EVALUATION

    SciTech Connect

    T. Wilson

    1999-11-12

    The purpose of this analysis is to evaluate impacts to the retrieval concept presented in the Design Analysis ''Retrieval Equipment and Strategy'' (Reference 6), from abnormal events based on Design Basis Events (DBE) and Beyond Design Basis Events (BDBE) as defined in two recent analyses: (1) DBE/Scenario Analysis for Preclosure Repository Subsurface Facilities (Reference 4); and (2) Preliminary Preclosure Design Basis Event Calculations for the Monitored Geologic Repository (Reference 5) The objective of this task is to determine what impacts the DBEs and BDBEs have on the equipment developed for retrieval. The analysis lists potential impacts and recommends changes to be analyzed in subsequent design analyses for developed equipment, or recommend where additional equipment may be needed, to allow retrieval to be performed in all DBE or BDBE situations. This analysis supports License Application design and therefore complies with the requirements of Systems Description Document input criteria comparison as presented in Section 7, Conclusions. In addition, the analysis discusses the impacts associated with not using concrete inverts in the emplacement drifts. The ''Retrieval Equipment and Strategy'' analysis was based on a concrete invert configuration in the emplacement drift. The scope of the analysis, as presented in ''Development Plan for Retrieval Events Evaluation'' (Reference 3) includes evaluation and criteria of the following: Impacts to retrieval from the emplacement drift based on DBE/BDBEs, and changes to the invert configuration for the preclosure period. Impacts to retrieval from the main drifts based on DBE/BDBEs for the preclosure period.

  16. Event sequence detector

    NASA Technical Reports Server (NTRS)

    Hanna, M. F. (Inventor)

    1973-01-01

    An event sequence detector is described with input units, each associated with a row of bistable elements arranged in an array of rows and columns. The detector also includes a shift register which is responsive to clock pulses from any of the units to sequentially provide signals on its output lines each of which is connected to the bistable elements in a corresponding column. When the event-indicating signal is received by an input unit it provides a clock pulse to the shift register to provide the signal on one of its output lines. The input unit also enables all its bistable elements so that the particular element in the column supplied with the signal from the register is driven to an event-indicating state.

  17. Detection of anomalous events

    DOEpatents

    Ferragut, Erik M.; Laska, Jason A.; Bridges, Robert A.

    2016-06-07

    A system is described for receiving a stream of events and scoring the events based on anomalousness and maliciousness (or other classification). The system can include a plurality of anomaly detectors that together implement an algorithm to identify low-probability events and detect atypical traffic patterns. The anomaly detector provides for comparability of disparate sources of data (e.g., network flow data and firewall logs.) Additionally, the anomaly detector allows for regulatability, meaning that the algorithm can be user configurable to adjust a number of false alerts. The anomaly detector can be used for a variety of probability density functions, including normal Gaussian distributions, irregular distributions, as well as functions associated with continuous or discrete variables.

  18. Low latency counter event indication

    DOEpatents

    Gara, Alan G.; Salapura, Valentina

    2010-08-24

    A hybrid counter array device for counting events with interrupt indication includes a first counter portion comprising N counter devices, each for counting signals representing event occurrences and providing a first count value representing lower order bits. An overflow bit device associated with each respective counter device is additionally set in response to an overflow condition. The hybrid counter array includes a second counter portion comprising a memory array device having N addressable memory locations in correspondence with the N counter devices, each addressable memory location for storing a second count value representing higher order bits. An operatively coupled control device monitors each associated overflow bit device and initiates incrementing a second count value stored at a corresponding memory location in response to a respective overflow bit being set. The incremented second count value is compared to an interrupt threshold value stored in a threshold register, and, when the second counter value is equal to the interrupt threshold value, a corresponding "interrupt arm" bit is set to enable a fast interrupt indication. On a subsequent roll-over of the lower bits of that counter, the interrupt will be fired.

  19. Low latency counter event indication

    DOEpatents

    Gara, Alan G.; Salapura, Valentina

    2008-09-16

    A hybrid counter array device for counting events with interrupt indication includes a first counter portion comprising N counter devices, each for counting signals representing event occurrences and providing a first count value representing lower order bits. An overflow bit device associated with each respective counter device is additionally set in response to an overflow condition. The hybrid counter array includes a second counter portion comprising a memory array device having N addressable memory locations in correspondence with the N counter devices, each addressable memory location for storing a second count value representing higher order bits. An operatively coupled control device monitors each associated overflow bit device and initiates incrementing a second count value stored at a corresponding memory location in response to a respective overflow bit being set. The incremented second count value is compared to an interrupt threshold value stored in a threshold register, and, when the second counter value is equal to the interrupt threshold value, a corresponding "interrupt arm" bit is set to enable a fast interrupt indication. On a subsequent roll-over of the lower bits of that counter, the interrupt will be fired.

  20. Superradiance initiated inside the ergoregion

    NASA Astrophysics Data System (ADS)

    Eskin, Gregory

    2016-11-01

    We consider the stationary metrics that have both the black hole and the ergoregion. The class of such metric contains, in particular, the Kerr metric. We study the Cauchy problem with highly oscillatory initial data supported in a neighborhood inside the ergoregion with some initial energy E0. We prove that when the time variable x0 increases this solution splits into two parts: one with the negative energy - E1 ending at the event horizon in a finite time, and the second part, with the energy E2 = E0 + E1 > E0, escaping, under some conditions, to the infinity when x0 → +∞. Thus we get the superradiance phenomenon. In the case of the Kerr metric the superradiance phenomenon is “short-lived”, since both the solutions with positive and negative energies cross the outer event horizon in a finite time (modulo O(1 k)) where k is a large parameter. We show that these solutions end on the singularity ring in a finite time. We study also the case of naked singularity.

  1. The emergence of events.

    PubMed

    Avrahami, J; Kareev, Y

    1994-12-01

    Although the concept of an event is widely used as the basic unit in the organization of experience, memory and meaning, little attention has been paid to how events emerge or what determines the boundaries of an event. It is usually taken for granted that one knows what an event is or how events are demarcated. In this paper an explanation is offered for the emergence of events, the cut hypothesis, which states: "A sub-sequence of stimuli is cut out of a sequence to become a cognitive entity if it has been experienced many times in different contexts", and three experiments to demonstrate the predictive power of the hypothesis are described. The stimuli in all three experiments were video films, constructed by randomly assembling short excerpts from movies. In the first experiment the cut hypothesis was juxtaposed with the thesis of demarcation at major changes, and it was shown that, after experiencing a certain repeating sequence, subjects hardly considered dividing at an internal point, even if it was a point of maximal change; points of maximal change were determined on the basis of performance by control subjects who did not experience the repeating sequence. In the second experiment the cut hypothesis was juxtaposed with an associationistic explanation; it was shown that subjects who viewed a certain sequence repeating in variable contexts recognized it better than subjects who had viewed the same sequence repeating always in the same context. In the third experiment a prediction of the hypothesis on recall behaviour was tested and it was shown that experience with sequences of stimuli repeating in various contexts results in cohesion of their elements.

  2. Scenario evolution: Interaction between event tree construction and numerical analyses

    SciTech Connect

    Barr, G.E.; Barnard, R.W.; Dockery, H.A.; Dunn, E.; MacIntyre, A.T.

    1990-12-31

    Construction of well-posed scenarios for the range of conditions possible at any proposed repository site is a critical first step to assessing total system performance. Event tree construction is the method that is being used to develop potential failure scenarios for the proposed nuclear waste repository at Yucca Mountain. An event tree begins with an initial event or condition. Subsequent events are listed in a sequence, leading eventually to release of radionuclides to the accessible environment. Ensuring the validity of the scenarios requires iteration between problems constructed using scenarios contained in the event tree sequence, experimental results, and numerical analyses. Details not adequately captured within the tree initially may become more apparent as a result of analyses. To illustrate this process, the authors discuss the iterations used to develop numerical analyses for PACE-90 (Performance Assessment Calculational Exercises) using basaltic igneous activity and human-intrusion event trees.

  3. Biological Event Modeling for Response Planning

    NASA Astrophysics Data System (ADS)

    McGowan, Clement; Cecere, Fred; Darneille, Robert; Laverdure, Nate

    People worldwide continue to fear a naturally occurring or terrorist-initiated biological event. Responsible decision makers have begun to prepare for such a biological event, but critical policy and system questions remain: What are the best courses of action to prepare for and react to such an outbreak? Where resources should be stockpiled? How many hospital resources—doctors, nurses, intensive-care beds—will be required? Will quarantine be necessary? Decision analysis tools, particularly modeling and simulation, offer ways to address and help answer these questions.

  4. Dioxin Exposure Initiative

    EPA Pesticide Factsheets

    The Dioxin Exposure Initiative (DEI) is no longer active. This page contains a summary of the dioxin exposure initiative with illustrations, contact and background information.Originally supported by scientist Matthew Lorber, who retired in Mar 2017.

  5. Structured events in Pamir carbon X-ray chambers

    NASA Technical Reports Server (NTRS)

    Leptukh, G. G.

    1985-01-01

    Experimental and theoretical investigations of structured events or narrow groups of hadrons in the Pamir carbon chambers are presented. These events are formed by the usual fluctuations of in-chamber development of nuclear electromagnetic cascade (NEC) initiated by a single hadron from the atmosphere.

  6. Teaching with Current Events

    ERIC Educational Resources Information Center

    Peralta, Andrew

    2005-01-01

    This article describes how a teacher changed all his plans to teach the hurricane. When the Hurricane Katrina hit the Gulf Coast, kids become naturally curious and seek answers in an event this big. The author suggests the use of tragedies to help them grow as students and as citizens.

  7. Brief resolved unexplained event

    PubMed Central

    Arane, Karen; Claudius, Ilene; Goldman, Ran D.

    2017-01-01

    Abstract Question For many years, the term apparent life-threatening event (ALTE) was associated with sudden infant death syndrome, and parents who described an acute event in their infants were sent to the hospital for admission. I understand that for infants new terminology is recommended. What is the current approach to a near-death experience of an infant? Answer A recent clinical practice guideline revised the name and definition of an ALTE to a brief resolved unexplained event (BRUE). The diagnosis of BRUE in infants younger than 1 year of age is made when infants experience 1 of the following BRUE symptoms: a brief episode (ie, less than 1 minute and usually less than 20 to 30 seconds) that is entirely resolved (infant is at baseline), which remains unexplained after the history and physical examination are completed, and includes an event characterized by cyanosis or pallor; absent, decreased, or irregular breathing; hypertonia or hypotonia; or altered responsiveness. Low-risk infants should not be admitted to the hospital and overtesting is discouraged. PMID:28115439

  8. Language As Social Event.

    ERIC Educational Resources Information Center

    Harste, Jerome C.

    A taxonomy developed for the study of the growth and development of written language from the perspective of social event was tested with a group of 68 children, aged three to six years. The subjects were presented with a wide variety of environmental print messages (road signs, toys, fast food signs, and household products) and were questioned…

  9. Television Ceremonial Events.

    ERIC Educational Resources Information Center

    Dayan, Daniel; Katz, Elihu

    1985-01-01

    Analyzes the impact of televised ceremonies (such as the marriage of Prince Charles and Lady Diana) as "media events" which allow viewers to vicariously enter into the ceremony. Compares them with cult movies that, over repeated viewing, encourage audience "participation." Focuses on the narrator's/commentator's role in shaping…

  10. Naive Probability: Model-Based Estimates of Unique Events.

    PubMed

    Khemlani, Sangeet S; Lotstein, Max; Johnson-Laird, Philip N

    2015-08-01

    We describe a dual-process theory of how individuals estimate the probabilities of unique events, such as Hillary Clinton becoming U.S. President. It postulates that uncertainty is a guide to improbability. In its computer implementation, an intuitive system 1 simulates evidence in mental models and forms analog non-numerical representations of the magnitude of degrees of belief. This system has minimal computational power and combines evidence using a small repertoire of primitive operations. It resolves the uncertainty of divergent evidence for single events, for conjunctions of events, and for inclusive disjunctions of events, by taking a primitive average of non-numerical probabilities. It computes conditional probabilities in a tractable way, treating the given event as evidence that may be relevant to the probability of the dependent event. A deliberative system 2 maps the resulting representations into numerical probabilities. With access to working memory, it carries out arithmetical operations in combining numerical estimates. Experiments corroborated the theory's predictions. Participants concurred in estimates of real possibilities. They violated the complete joint probability distribution in the predicted ways, when they made estimates about conjunctions: P(A), P(B), P(A and B), disjunctions: P(A), P(B), P(A or B or both), and conditional probabilities P(A), P(B), P(B|A). They were faster to estimate the probabilities of compound propositions when they had already estimated the probabilities of each of their components. We discuss the implications of these results for theories of probabilistic reasoning.

  11. Agriculture: Natural Events and Disasters

    EPA Pesticide Factsheets

    Natural Events and DiasastersInformation on Natural Events and Disasters. Every year natural disasters, such as hurricanes, floods, fires, earthquakes, and tornadoes, challenge agricultural production.

  12. A mechanical energy analysis of gait initiation

    NASA Technical Reports Server (NTRS)

    Miller, C. A.; Verstraete, M. C.

    1999-01-01

    The analysis of gait initiation (the transient state between standing and walking) is an important diagnostic tool to study pathologic gait and to evaluate prosthetic devices. While past studies have quantified mechanical energy of the body during steady-state gait, to date no one has computed the mechanical energy of the body during gait initiation. In this study, gait initiation in seven normal male subjects was studied using a mechanical energy analysis to compute total body energy. The data showed three separate states: quiet standing, gait initiation, and steady-state gait. During gait initiation, the trends in the energy data for the individual segments were similar to those seen during steady-state gait (and in Winter DA, Quanbury AO, Reimer GD. Analysis of instantaneous energy of normal gait. J Biochem 1976;9:253-257), but diminished in amplitude. However, these amplitudes increased to those seen in steady-state during the gait initiation event (GIE), with the greatest increase occurring in the second step due to the push-off of the foundation leg. The baseline level of mechanical energy was due to the potential energy of the individual segments, while the cyclic nature of the data was indicative of the kinetic energy of the particular leg in swing phase during that step. The data presented showed differences in energy trends during gait initiation from those of steady state, thereby demonstrating the importance of this event in the study of locomotion.

  13. Initiation of vascular development.

    PubMed

    Ohashi-Ito, Kyoko; Fukuda, Hiroo

    2014-06-01

    The initiation of vascular development occurs during embryogenesis and the development of lateral organs, such as lateral roots and leaves. Understanding the mechanism underlying the initiation of vascular development has been an important goal of plant biologists. Auxin flow is a crucial factor involved in the initiation of vascular development. In addition, recent studies have identified key factors that regulate the establishment of vascular initial cells in embryos and roots. In this review, we summarize the recent findings in this field and discuss the initiation of vascular development.

  14. Gamma-Ray Bursts: Sans Second Postulate

    NASA Astrophysics Data System (ADS)

    Fritzius, R.

    In 1950, Albert Einstein intimated to Robert Shankland that in the years prior to 1905 he had considered using an emission theory [similar to that which Swiss Physicist Walter Ritz propounded in 1908.] In Ritz's theory the velocity of light with respect to an observer is c + v, where c is the velocity of light with respect to its source, and v is the relative velocity between the source and the observer. Einstein abandoned the c+v approach because he could think of no form of differential equation that could have solutions representing waves whose velocity depended [in part] on the motion of the source. For binary stars the c + v approach would predict "observed" phase relations for light arriving from different parts of a given component's orbit, such that the observed light would be, according to Einstein, all badly "mixed up" and might even "back up on itself." In 1913, the Dutch astronomer, Willem de Sitter, urged abandonment of Ritz's c + v relativity by showing that binary stars failed to provide evidence of the "mixed up" light phasing. (Apparent departures from Keplerian motion, including seeing the same star on opposite sides of its orbit at the same time [at the appropriate observer distance] were predicted by Ritz's c +v relativity.) In 1987, Vladimir Sekerin, at Tomsk University, announced that de Sitter failed to address the fact that for the observer-distances required to produce the star-in-two-places-at-once phenomenon, the angular diameter of the binary component's orbit (from the observer's viewpoint) would be too small for our atmospherically limited earth-borne "seeing" to resolve the images. In essence, de Sitter did not "de throne" Ritz. Sekerin then showed how de Sitter's binary star scenario could be interpreted as evidence "for" the Ritzian theory. (Two images briefly on top of one another will be briefly twice as bright as a single image.) He used de Sitter's equations to analog compute light curves of a number of different kinds variable stars starting with Cepheid variables. The author cleared up a critical flaw in Sekerin's reasoning regarding the computed value of the periodic spectral variations involved, and created software simulations of binary star orbits which produce the light curves and spectral variations predicted by the Ritzian theory. (Constant speed-of-light simulations do not produce the variations.) A limited number of these simulations including some for various kinds of Gamma-Ray Bursts (GRBs) are to be shown as part of this presentation. High-resolution spectral studies of variable stars, including GRBs, may eventually help us decide whether or not Ritz was as wrong as is currently generally thought. Further information on this topic is available at: http://www.ebicom.net/~rsf1/binaries.htm

  15. Event boundaries and anaphoric reference.

    PubMed

    Thompson, Alexis N; Radvansky, Gabriel A

    2016-06-01

    The current study explored the finding that parsing a narrative into separate events impairs anaphor resolution. According to the Event Horizon Model, when a narrative event boundary is encountered, a new event model is created. Information associated with the prior event model is removed from working memory. So long as the event model containing the anaphor referent is currently being processed, this information should still be available when there is no narrative event boundary, even if reading has been disrupted by a working-memory-clearing distractor task. In those cases, readers may reactivate their prior event model, and anaphor resolution would not be affected. Alternatively, comprehension may not be as event oriented as this account suggests. Instead, any disruption of the contents of working memory during comprehension, event related or not, may be sufficient to disrupt anaphor resolution. In this case, reading comprehension would be more strongly guided by other, more basic language processing mechanisms and the event structure of the described events would play a more minor role. In the current experiments, participants were given stories to read in which we included, between the anaphor and its referent, either the presence of a narrative event boundary (Experiment 1) or a narrative event boundary along with a working-memory-clearing distractor task (Experiment 2). The results showed that anaphor resolution was affected by narrative event boundaries but not by a working-memory-clearing distractor task. This is interpreted as being consistent with the Event Horizon Model of event cognition.

  16. Biological event composition

    PubMed Central

    2012-01-01

    Background In recent years, biological event extraction has emerged as a key natural language processing task, aiming to address the information overload problem in accessing the molecular biology literature. The BioNLP shared task competitions have contributed to this recent interest considerably. The first competition (BioNLP'09) focused on extracting biological events from Medline abstracts from a narrow domain, while the theme of the latest competition (BioNLP-ST'11) was generalization and a wider range of text types, event types, and subject domains were considered. We view event extraction as a building block in larger discourse interpretation and propose a two-phase, linguistically-grounded, rule-based methodology. In the first phase, a general, underspecified semantic interpretation is composed from syntactic dependency relations in a bottom-up manner. The notion of embedding underpins this phase and it is informed by a trigger dictionary and argument identification rules. Coreference resolution is also performed at this step, allowing extraction of inter-sentential relations. The second phase is concerned with constraining the resulting semantic interpretation by shared task specifications. We evaluated our general methodology on core biological event extraction and speculation/negation tasks in three main tracks of BioNLP-ST'11 (GENIA, EPI, and ID). Results We achieved competitive results in GENIA and ID tracks, while our results in the EPI track leave room for improvement. One notable feature of our system is that its performance across abstracts and articles bodies is stable. Coreference resolution results in minor improvement in system performance. Due to our interest in discourse-level elements, such as speculation/negation and coreference, we provide a more detailed analysis of our system performance in these subtasks. Conclusions The results demonstrate the viability of a robust, linguistically-oriented methodology, which clearly distinguishes

  17. Events and subjective well-being: only recent events matter.

    PubMed

    Suh, E; Diener, E; Fujita, F

    1996-05-01

    The effect of life events on subjective well-being (SWB) was explored in a 2-year longitudinal study of 115 participants. It was found that only life events during the previous 3 months influenced life satisfaction and positive and negative affect. Although recent life events influenced SWB even when personality at Time 1 was controlled, distal life events did not correlate with SWB. SWB and life events both showed a substantial degree of temporal stability. It was also found that good and bad life events tend to covary, both between individuals and across periods of the lives of individuals. Also, when events of the opposite valence were controlled, events correlated more strongly with SWB. The counterintuitive finding that good and bad events co-occur suggests an exciting avenue for explorations of the structure of life events.

  18. Parton shower Monte Carlo event generators

    NASA Astrophysics Data System (ADS)

    Webber, Bryan

    2011-12-01

    A parton shower Monte Carlo event generator is a computer program designed to simulate the final states of high-energy collisions in full detail down to the level of individual stable particles. The aim is to generate a large number of simulated collision events, each consisting of a list of final-state particles and their momenta, such that the probability to produce an event with a given list is proportional (approximately) to the probability that the corresponding actual event is produced in the real world. The Monte Carlo method makes use of pseudorandom numbers to simulate the event-to-event fluctuations intrinsic to quantum processes. The simulation normally begins with a hard subprocess, shown as a black blob in Figure 1, in which constituents of the colliding particles interact at a high momentum scale to produce a few outgoing fundamental objects: Standard Model quarks, leptons and/or gauge or Higgs bosons, or hypothetical particles of some new theory. The partons (quarks and gluons) involved, as well as any new particles with colour, radiate virtual gluons, which can themselves emit further gluons or produce quark-antiquark pairs, leading to the formation of parton showers (brown). During parton showering the interaction scale falls and the strong interaction coupling rises, eventually triggering the process of hadronization (yellow), in which the partons are bound into colourless hadrons. On the same scale, the initial-state partons in hadronic collisions are confined in the incoming hadrons. In hadron-hadron collisions, the other constituent partons of the incoming hadrons undergo multiple interactions which produce the underlying event (green). Many of the produced hadrons are unstable, so the final stage of event generation is the simulation of the hadron decays.

  19. Empirical reconstruction of storm-time steady magnetospheric convection events

    NASA Astrophysics Data System (ADS)

    Stephens, G. K.; Sitnov, M. I.; Kissinger, J.; Tsyganenko, N. A.; McPherron, R. L.; Korth, H.; Anderson, B. J.

    2013-12-01

    We investigate the storm-scale morphology of the magnetospheric magnetic field as well as underlying distributions of electric currents, equatorial plasma pressure and entropy for four Steady Magnetospheric Convection (SMC) events that occurred during the May 2000 and October 2011 magnetic storms. The analysis is made using the empirical geomagnetic field model TS07D, in which the structure of equatorial currents is not predefined and it is dictated by data. The model also combines the strengths of statistical and event-oriented approaches in mining data for the reconstruction of the magnetic field. The formation of a near-Earth minimum of the equatorial magnetic field in the midnight sector is inferred from data without ad hoc assumptions of a special current system postulated in earlier empirical reconstructions. In addition, a new SMC class is discovered where the minimum equatorial field is substantially larger and located closer to Earth. The magnetic field tailward of the minimum is also much larger, and the corresponding region of accumulated magnetic flux may occupy a very short tail region. The equatorial current and plasma pressure are found to be strongly enhanced far beyond geosynchronous orbit and in a broad local time interval covering the whole nightside region. This picture is consistent with independent recent statistical studies of the SMC pressure distributions, global MHD and kinetic RCM-E simulations. Distributions of the flux tube volume and entropy inferred from data reveal different mechanisms of the magnetotail convection crisis resolution for two classes of SMC events.

  20. Single event mass spectrometry

    DOEpatents

    Conzemius, Robert J.

    1990-01-16

    A means and method for single event time of flight mass spectrometry for analysis of specimen materials. The method of the invention includes pulsing an ion source imposing at least one pulsed ion onto the specimen to produce a corresponding emission of at least one electrically charged particle. The emitted particle is then dissociated into a charged ion component and an uncharged neutral component. The ion and neutral components are then detected. The time of flight of the components are recorded and can be used to analyze the predecessor of the components, and therefore the specimen material. When more than one ion particle is emitted from the specimen per single ion impact, the single event time of flight mass spectrometer described here furnis This invention was made with Government support under Contract No. W-7405-ENG82 awarded by the Department of Energy. The Government has certain rights in the invention.

  1. Transionospheric chirp event classifier

    SciTech Connect

    Argo, P.E.; Fitzgerald, T.J.; Freeman, M.J.

    1995-09-01

    In this paper we will discuss a project designed to provide computer recognition of the transionospheric chirps/pulses measured by the Blackbeard (BB) satellite, and expected to be measured by the upcoming FORTE satellite. The Blackbeard data has been perused by human means -- this has been satisfactory for the relatively small amount of data taken by Blackbeard. But with the advent of the FORTE system, which by some accounts might ``see`` thousands of events per day, it is important to provide a software/hardware method of accurately analyzing the data. In fact, we are providing an onboard DSP system for FORTE, which will test the usefulness of our Event Classifier techniques in situ. At present we are constrained to work with data from the Blackbeard satellite, and will discuss the progress made to date.

  2. Transionospheric chirp event classifier

    NASA Astrophysics Data System (ADS)

    Argo, P. E.; Fitzgerald, T. J.; Freeman, M. J.

    In this paper we will discuss a project designed to provide computer recognition of the transionospheric chirps/pulses measured by the Blackbeard (BB) satellite, and expected to be measured by the upcoming FORTE satellite. The Blackbeard data has been perused by human means - this has been satisfactory for the relatively small amount of data taken by Blackbeard. But with the advent of the FORTE system, which by some accounts might 'see' thousands of events per day, it is important to provide a software/hardware method of accurately analyzing the data. In fact, we are providing an onboard DSP system for FORTE, which will test the usefulness of our Event Classifier techniques in situ. At present we are constrained to work with data from the Blackbeard satellite, and will discuss the progress made to date.

  3. The initiation of eukaryotic and prokaryotic protein synthesis: a selective accessibility and multisubstrate enzyme reaction.

    PubMed

    Nakamoto, Tokumasa

    2007-11-15

    An extension of our unique accessibility hypothesis for the initiation of protein synthesis is proposed following a review of the initiation of protein synthesis. The E. coli model initiation sequence generated by computer from 68 initiation sequences and the eukaryotic consensus initiation sequence derived by non-computer analysis of 211 initiation sequences do not contain a specific base in any position; they are only assigned preferred bases. The initiation site, in other words, is a varied sequence of preferred bases and its sequence is non-unique. This indicates that the ribosomal recognition of the initiation site may be the result of multiple interactions that are cooperative and cumulative and typical of multisubstrate enzymes. Because of this characteristic, the model of multisubstrate enzymes with broad substrate specificity is proposed as a paradigm for the initiation of protein synthesis. As predicted by this model, changes in the leader and downstream sequences that improve the agreement with the preferred base sequence do indeed enhance the rate of protein synthesis. The eukaryotic/prokaryotic hybrid studies show a considerable overlap in the specificities of the two groups of ribosomes. The scanning of the mRNA from the 5'-end postulated by the scanning hypothesis is not a necessary step since eukaryotic ribosomes are able to bind to internal mRNA sites and initiate synthesis. Our unique accessibility hypothesis, which is extended by coupling cooperative and cumulative specificity in ribosomal function, is referred to for brevity as the cumulative specificity hypothesis. The hypothesis actually postulates a selective accessibility and cooperative-cumulative specificity mechanism; it is able to account for the behavior of both eukaryotic and prokaryotic initiation of protein synthesis. From another perspective, the hypothesis can be regarded as providing a mechanism that enables ribosomes to recognize the IS in the absence of a unique initiation

  4. Traumatic-event headaches

    PubMed Central

    2004-01-01

    Background Chronic headaches from head trauma and whiplash injury are well-known and common, but chronic headaches from other sorts of physical traumas are not recognized. Methods Specific information was obtained from the medical records of 15 consecutive patients with chronic headaches related to physically injurious traumatic events that did not include either head trauma or whiplash injury. The events and the physical injuries produced by them were noted. The headaches' development, characteristics, duration, frequency, and accompaniments were recorded, as were the patients' use of pain-alleviative drugs. From this latter information, the headaches were classified by the diagnostic criteria of the International Headache Society as though they were naturally-occurring headaches. The presence of other post-traumatic symptoms and litigation were also recorded. Results The intervals between the events and the onset of the headaches resembled those between head traumas or whiplash injuries and their subsequent headaches. The headaches themselves were, as a group, similar to those after head trauma and whiplash injury. Thirteen of the patients had chronic tension-type headache, two had migraine. The sustained bodily injuries were trivial or unidentifiable in nine patients. Fabrication of symptoms for financial remuneration was not evident in these patients of whom seven were not even seeking payments of any kind. Conclusions This study suggests that these hitherto unrecognized post-traumatic headaches constitute a class of headaches characterized by a relation to traumatic events affecting the body but not including head or whiplash traumas. The bodily injuries per se can be discounted as the cause of the headaches. So can fabrication of symptoms for financial remuneration. Altered mental states, not systematically evaluated here, were a possible cause of the headaches. The overall resemblance of these headaches to the headaches after head or whiplash traumas implies

  5. "Big Events" and Networks.

    PubMed

    Friedman, Samuel; Rossi, Diana; Flom, Peter L

    2006-01-01

    Some, but not all, "big events" such as wars, revolutions, socioeconomic transitions, economic collapses, and ecological disasters in recent years seem to lead to large-scale HIV outbreaks (Friedman et al, in press; Hankins et al 2002). This was true of transitions in the USSR, South Africa and Indonesia, for example, but not those in the Philippines or (so far) in Argentina. It has been hypothesized that whether or not HIV outbreaks occur is shaped in part by the nature and extent of changes in the numbers of voluntary or involuntary risk-takers, which itself may be related to the growth of roles such as sex-sellers or drug sellers; the riskiness of the behaviors engaged in by risk-takers; and changes in sexual and injection networks and other "mixing patterns" variables. Each of these potential causal processes, in turn, is shaped by the nature of pre-existing social networks and the patterns and content of normative regulation and communication that happen within these social networks-and on how these social networks and their characteristics are changed by the "big event" in question. We will present ideas about what research is needed to help understand these events and to help guide both indigenous community-based efforts to prevent HIV outbreaks and also to guide those who organize external intervention efforts and aid.

  6. Predictability of rogue events.

    PubMed

    Birkholz, Simon; Brée, Carsten; Demircan, Ayhan; Steinmeyer, Günter

    2015-05-29

    Using experimental data from three different rogue wave supporting systems, determinism, and predictability of the underlying dynamics are evaluated with methods of nonlinear time series analysis. We included original records from the Draupner platform in the North Sea as well as time series from two optical systems in our analysis. One of the latter was measured in the infrared tail of optical fiber supercontinua, the other in the fluence profiles of multifilaments. All three data sets exhibit extreme-value statistics and exceed the significant wave height in the respective system by a factor larger than 2. Nonlinear time series analysis indicates a different degree of determinism in the systems. The optical fiber scenario is found to be driven by quantum noise whereas rogue waves emerge as a consequence of turbulence in the others. With the large number of rogue events observed in the multifilament system, we can systematically explore the predictability of such events in a turbulent system. We observe that rogue events do not necessarily appear without a warning, but are often preceded by a short phase of relative order. This surprising finding sheds some new light on the fascinating phenomenon of rogue waves.

  7. Some Aviation Growth Events

    NASA Technical Reports Server (NTRS)

    Spearman, M. Leroy

    2002-01-01

    The growth of aviation since the first flight of a heavier-than-air powered manned vehicle in 1903 has been somewhat remarkable. Some of the events that have influenced this growth are reviewed in this paper. This review will include some events prior to World War I; the influence of the war itself; the events during the post-war years including the establishment of aeronautical research laboratories; and the influence of World War II which, among other things, introduced new technologies that included rocket and jet propulsion and supersonic aerodynamics. The subsequent era of aeronautical research and the attendant growth in aviation over the past half century will be reviewed from the view point of the author who, since 1944, has been involved in the NACA/NASA aeronautical research effort at what is now the Langley Research Center in Hampton, Virginia. The review will discuss some of the research programs related to the development of some experimental aircraft, the Century series of fighter aircraft, multi-mission aircraft, advanced military aircraft and missiles, advanced civil aircraft, supersonic transports, spacecraft and others.

  8. Documents Pertaining to Resource Conservation and Recovery Act Corrective Action Event Codes

    EPA Pesticide Factsheets

    Document containing RCRA Corrective Action event codes and definitions, including national requirements, initiating sources, dates, and guidance, from the first facility assessment until the Corrective Action is terminated.

  9. Progress in Initiator Modeling

    SciTech Connect

    Hrousis, C A; Christensen, J S

    2009-05-04

    There is great interest in applying magnetohydrodynamic (MHD) simulation techniques to the designs of electrical high explosive (HE) initiators, for the purpose of better understanding a design's sensitivities, optimizing its performance, and/or predicting its useful lifetime. Two MHD-capable LLNL codes, CALE and ALE3D, are being used to simulate the process of ohmic heating, vaporization, and plasma formation in the bridge of an initiator, be it an exploding bridgewire (EBW), exploding bridgefoil (EBF) or slapper type initiator. The initiation of the HE is simulated using Tarver Ignition & Growth reactive flow models. 1-D, 2-D and 3-D models have been constructed and studied. The models provide some intuitive explanation of the initiation process and are useful for evaluating the potential impact of identified aging mechanisms (such as the growth of intermetallic compounds or powder sintering). The end product of this work is a simulation capability for evaluating margin in proposed, modified or aged initiation system designs.

  10. Monitoring Abortive Initiation

    PubMed Central

    Hsu, Lilian M.

    2009-01-01

    Abortive initiation, when first discovered, was an enigmatic phenomenon, but fully three decades hence, it has been shown to be an integral step in the transcript initiation process intimately tied to the promoter escape reaction undergone by RNA polymerase at the initiation-elongation transition. A detailed understanding of abortive initiation-promoter escape has brought within reach a full description of the transcription initiation mechanism. This enormous progress was the result of convergent biochemical, genetic, and biophysical investigations propelled by parallel advances in quantitation technology. This chapter discusses the knowledge gained through the biochemical approach and a high-resolution method that yields quantitative and qualitative information regarding abortive initiation-promoter escape at a promoter. PMID:18948204

  11. The Maine Event

    ERIC Educational Resources Information Center

    McHale, Tom

    2007-01-01

    In this article, the author describes the successful laptop program employed at Mt. Abram High School in Strong, Maine. Through the Maine Learning Technology Initiative, the school has issued laptops to all 36,000 teachers and students in grades 7-8. This program has helped level the playing field for a student population that is 50 percent to 55…

  12. Event selection services in ATLAS

    NASA Astrophysics Data System (ADS)

    Cranshaw, J.; Cuhadar-Donszelmann, T.; Gallas, E.; Hrivnac, J.; Kenyon, M.; McGlone, H.; Malon, D.; Mambelli, M.; Nowak, M.; Viegas, F.; Vinek, E.; Zhang, Q.

    2010-04-01

    ATLAS has developed and deployed event-level selection services based upon event metadata records ("TAGS") and supporting file and database technology. These services allow physicists to extract events that satisfy their selection predicates from any stage of data processing and use them as input to later analyses. One component of these services is a web-based Event-Level Selection Service Interface (ELSSI). ELSSI supports event selection by integrating run-level metadata, luminosity-block-level metadata (e.g., detector status and quality information), and event-by-event information (e.g., triggers passed and physics content). The list of events that survive after some selection criterion is returned in a form that can be used directly as input to local or distributed analysis; indeed, it is possible to submit a skimming job directly from the ELSSI interface using grid proxy credential delegation. ELSSI allows physicists to explore ATLAS event metadata as a means to understand, qualitatively and quantitatively, the distributional characteristics of ATLAS data. In fact, the ELSSI service provides an easy interface to see the highest missing ET events or the events with the most leptons, to count how many events passed a given set of triggers, or to find events that failed a given trigger but nonetheless look relevant to an analysis based upon the results of offline reconstruction, and more. This work provides an overview of ATLAS event-level selection services, with an emphasis upon the interactive Event-Level Selection Service Interface.

  13. [Initiation, promotion, initiation experiments with radon and cigarette smoke: Lung tumors in rats]. Progress report

    SciTech Connect

    Moolgavkar, S.H.

    1994-10-01

    During the past several years, the authors have made considerable progress in modeling carcinogenesis in general, and in modeling radiation carcinogenesis, in particular. They present an overview of their progress in developing stochastic carcinogenesis models and applying them to experimental and epidemiologic data sets. Traditionally, cancer models have been used for the analysis of incidence (or prevalence) data in epidemiology and time to tumor data in experimental studies. The relevant quantities for the analysis of these data are the hazard function and the probability of tumor. The derivation of these quantities is briefly described here. More recently, the authors began to use these models for the analysis of data on intermediate lesions on the pathway to cancer. Such data are available in experimental carcinogenesis studies, in particular in initiation and promotion studies on the mouse skin and the rat liver. If however, quantitative information on intermediate lesions on the pathway to lung cancer were to be come available at some future date, the methods that they have developed for the analysis of initiation-promotion experiments could easily be applied to the analysis of these lesions. The mathematical derivations here are couched in terms of a particular two-mutation model of carcinogenesis. Extension to models postulating more than two mutations is not always straightforward.

  14. Testosterone therapy, thrombosis, thrombophilia, cardiovascular events.

    PubMed

    Glueck, Charles J; Wang, Ping

    2014-08-01

    There are similar time intervals between starting testosterone therapy (TT) and development of thrombotic (~4.5 months) or cardiovascular (CVD) events (~3 months) which may, speculatively, reflect a shared pathophysiology. We have described thrombotic events 5 months (median) after starting TT in 38 men and 4 women, including 27 with deep venous thrombosis-pulmonary embolism, 12 with osteonecrosis, 1 with central retinal vein thrombosis, 1 with amaurosis fugax, and 1 with spinal cord infarction. In 8 men whose TT was continued, second thrombotic events occurred despite adequate anticoagulation with Coumadin in 8 men, 3 of whom had a third thrombotic event. Of these 42 cases, 40 had measures of thrombophilia-hypofibrinolysis, and 39 were found to have previously undiagnosed thrombophilia-hypofibrinolysis. Before beginning TT, especially in men with previous history of thrombotic events, we suggest that, at a minimum, measurements be made for the Factor V Leiden and Prothrombin mutations, Factors VIII and XI, and homocysteine, to identify men who should not receive TT. We need prospective data focused on whether there should be pre-TT screening based on history of previous venous thromboembolism or for all subjects for major gene thrombophilias. To better resolve questions about TT and all cause and cardiovascular morbidity and mortality and thrombosis, a long term, prospective, randomized, blinded study following the example of the Women's Health Initiative is needed. While we wait for prospective placebo-controlled TT outcome data, TT should be restricted to men with well-defined androgen deficiency syndromes.

  15. Event mapping meeting

    SciTech Connect

    Eaton, L.; Mason, D.

    1997-02-20

    A one-day meeting was held by the authors to evaluate how the strategic lab workshops would tie to this year`s tactical planning exercise. In particular, they wanted to find recent events that would support the tactical goal decisions of the Lab, and they wanted to find events that verify the Lab`s present course. The events which are each briefly discussed are: Galvin Commission recommends consolidating DOE defense labs (1995); Congressional subcommittee staff force budget cuts and consolidation (1995); 28% of DOE/DP budget held back pending completion of a clear 5-yr plan for nukes (1995); DOD and DOE focus on dual use (1995); LANL work includes weapons rebuilds (1995); LANL chosen by DOE to develop and test advanced remediation techniques (1995); AGEX/DARHT Project is stopped by suits from environmental activities (1996); Non-proliferation treaty renewed (1996); US complies with Comprehensive Test Ban Treaty (1996); Capability based deterrence policy put into place (1998); Stockpile shrinks to approximately 2000 weapons (2005); DOE weapons labs re-chartered as true national labs (1996); DOE terminates all nuclear weapons testing support (1996); Industrial projects at LANL up 20% from previous year (1997); NIST-ATP Program becomes an interagency process (1997); DOE warns that spent commercial reactor fuels is a major proliferation threat (1998); Non-lethal weapons work helps to reshape LANL image (1998); Global warning theory proven (2005); Overall US spending on science has been flat or decreasing for three years (1998); and Economic role of LANL in northern New Mexico declines (2005).

  16. Microlensing Event Caustic Crossing

    NASA Astrophysics Data System (ADS)

    MACHO/GMAN Collaboration

    1998-06-01

    The MACHO/GMAN Collaboration (cf. IAUC 6845) plus affiliate S.Rhie report that further observations of microlensing event MACHO-98-SMC-1 (R.A. = 0h45m35s.2, Decl. = -72o52'34" J2000) confirm the binary lens interpretation and yield a prediction for the time of the 2nd caustic crossing: June 19.2 +/- 1.5 UT. The confirming observations were obtained with the MSO 1.3m MACHO survey telescope and the CTIO 0.9-m telescope.

  17. Detection of solar events

    DOEpatents

    Fischbach, Ephraim; Jenkins, Jere

    2013-08-27

    A flux detection apparatus can include a radioactive sample having a decay rate capable of changing in response to interaction with a first particle or a field, and a detector associated with the radioactive sample. The detector is responsive to a second particle or radiation formed by decay of the radioactive sample. The rate of decay of the radioactive sample can be correlated to flux of the first particle or the field. Detection of the first particle or the field can provide an early warning for an impending solar event.

  18. Winning with Initiative

    ERIC Educational Resources Information Center

    Morgan, Matthew J.

    2004-01-01

    A common complaint among high school coaches is the lack of initiative shown by some of their players. Coaches expect a certain level of decision-making and independence, and more so from team captains and senior players. Developing leadership skills is a major benefit to athletes who participate at a competitive level, and taking initiative can…

  19. The Fostering Hope Initiative

    ERIC Educational Resources Information Center

    Rider, Steven; Winters, Katie; Dean, Joyce; Seymour, Jim

    2014-01-01

    The Fostering Hope Initiative is a neighborhood-based Collective Impact initiative that promotes optimum child and youth development by supporting vulnerable families, encouraging connections between neighbors, strengthening systems to ensure collective impact, and advocating for family-friendly public policy. This article describes the…

  20. Prioritizing Scientific Initiatives.

    ERIC Educational Resources Information Center

    Bahcall, John N.

    1991-01-01

    Discussed is the way in which a limited number of astronomy research initiatives were chosen and prioritized based on a consensus of members from the Astronomy and Astrophysics Survey Committee. A list of recommended equipment initiatives and estimated costs is provided. (KR)

  1. Synchronized passive imaging of single cavitation events

    NASA Astrophysics Data System (ADS)

    Gateau, Jérôme; Aubry, Jean-François; Pernot, Mathieu; Chauvet, Daurian; Boch, Anne-Laure; Fink, Mathias; Tanter, Mickaël

    2011-09-01

    Passive cavitation detection techniques are usually of relatively low sensitivity to single cavitation events. Moreover, a single-element transducer is generally used, so that the spatial localization of these cavitation events is not possible, or is limited to the probing volume. To both detect and localize single cavitation events over an extended volume, the following experimental set-up has been used and validated: cavitation is induced with a focused single-element transducer (mean frequency 660 kHz, f♯ = 1) driven by a high power (up to 5 kW) electric burst of a few cycles, and the acoustic emission of the bubbles is recorded on a standard linear array (4-7 MHz), mounted on the side of the single element to probe its focal spot. Both the frequencies and the geometry used are appropriate to in vivo implementation. The recording of ultrasonic radio-frequency (RF) data was performed simultaneously on 64 channels of the array and was synchronized with the pulsed excitation. A single cavitation event results in a high frequency and coherent wave front on the RF data. Thanks to synchronization, these RF data are beam-formed to localize the event with a axial resolution of 0.3 mm. A small number of discrete events could also be separated with this method. Besides, B-mode images obtained with the linear array prior to passive detection allowed the positioning of the events within the tissue structure. This technique has been used first ex vivo on freshly harve pig and sheep thigh muscle: with a two cycle excitation, a 9 MPa cavitation threshold was found. Cavitation detection was also achieved in vivo with a five cycle burst excitation in sheep thigh muscle for a peak acoustic pressure of 11MPa. This technique could provide useful information in order to better understand, control and monitor the initiation phase of the histotripsy process.

  2. Deep Sludge Gas Release Event Analytical Evaluation

    SciTech Connect

    Sams, Terry L.

    2013-08-15

    Long Abstract. Full Text. The purpose of the Deep Sludge Gas Release Event Analytical Evaluation (DSGRE-AE) is to evaluate the postulated hypothesis that a hydrogen GRE may occur in Hanford tanks containing waste sludges at levels greater than previously experienced. There is a need to understand gas retention and release hazards in sludge beds which are 200 -300 inches deep. These sludge beds are deeper than historical Hanford sludge waste beds, and are created when waste is retrieved from older single-shell tanks (SST) and transferred to newer double-shell tanks (DST).Retrieval of waste from SSTs reduces the risk to the environment from leakage or potential leakage of waste into the ground from these tanks. However, the possibility of an energetic event (flammable gas accident) in the retrieval receiver DST is worse than slow leakage. Lines of inquiry, therefore, are (1) can sludge waste be stored safely in deep beds; (2) can gas release events (GRE) be prevented by periodically degassing the sludge (e.g., mixer pump); or (3) does the retrieval strategy need to be altered to limit sludge bed height by retrieving into additional DSTs? The scope of this effort is to provide expert advice on whether or not to move forward with the generation of deep beds of sludge through retrieval of C-Farm tanks. Evaluation of possible mitigation methods (e.g., using mixer pumps to release gas, retrieving into an additional DST) are being evaluated by a second team and are not discussed in this report. While available data and engineering judgment indicate that increased gas retention (retained gas fraction) in DST sludge at depths resulting from the completion of SST 241-C Tank Farm retrievals is not expected and, even if gas releases were to occur, they would be small and local, a positive USQ was declared (Occurrence Report EM-RP--WRPS-TANKFARM-2012-0014, "Potential Exists for a Large Spontaneous Gas Release Event in Deep Settled Waste Sludge"). The purpose of this technical

  3. Homocysteine lowering interventions for preventing cardiovascular events

    PubMed Central

    Martí-Carvajal, Arturo J; Solà, Ivan; Lathyris, Dimitrios; Salanti, Georgia

    2014-01-01

    Background Cardiovascular disease such as coronary artery disease, stroke and congestive heart failure, is a leading cause of death worldwide. A postulated risk factor is elevated circulating total homocysteine (tHcy) levels which is influenced mainly by blood levels of cyanocobalamin (vitamin B12), folic acid (vitamin B9) and pyridoxine (vitamin B6). There is uncertainty regarding the strength of association between tHcy and the risk of cardiovascular disease. Objectives To assess the clinical effectiveness of homocysteine-lowering interventions (HLI) in people with or without pre-existing cardiovascular disease. Search methods We searched The Cochrane Central Register of Controlled Trials (CENTRAL) on The Cochrane Library (issue 3 2008), MEDLINE (1950 to August 2008), EMBASE (1988 to August 2008), and LILACS (1982 to September 2, 2008). We also searched in Allied and Complementary Medicine (AMED; 1985 to August 2008), ISI Web of Science (1993 to August 2008), and the Cochrane Stroke Group Specialised Register (April 2007). We hand searched pertinent journals and the reference lists of included papers. We also contacted researchers in the field. There was no language restriction in the search. Selection criteria We included randomised clinical trials (RCTs) assessing the effects of HLI for preventing cardiovascular events with a follow-up period of 1 year or longer. We considered myocardial infarction and stroke as the primary outcomes. We excluded studies in patients with end-stage renal disease. Data collection and analysis We independently performed study selection, risk of bias assessment and data extraction. We estimated relative risks (RR) for dichotomous outcomes. We measured statistical heterogeneity using I2. We used a random-effects model to synthesise the findings. Main results We included eight RCTs involving 24,210 participants with a low risk of bias in general terms. HLI did not reduce the risk of non-fatal or fatal myocardial infarction, stroke, or

  4. Relativistic tidal disruption events

    NASA Astrophysics Data System (ADS)

    Levan, A.

    2012-12-01

    In March 2011 Swift detected an extremely luminous and long-lived outburst from the nucleus of an otherwise quiescent, low luminosity (LMC-like) galaxy. Named Swift J1644+57, its combination of high-energy luminosity (1048 ergs s-1 at peak), rapid X-ray variability (factors of >100 on timescales of 100 seconds) and luminous, rising radio emission suggested that we were witnessing the birth of a moderately relativistic jet (Γ ˜ 2 - 5), created when a star is tidally disrupted by the supermassive black hole in the centre of the galaxy. A second event, Swift J2058+0516, detected two months later, with broadly similar properties lends further weight to this interpretation. Taken together this suggests that a fraction of tidal disruption events do indeed create relativistic outflows, demonstrates their detectability, and also implies that low mass galaxies can host massive black holes. Here, I briefly outline the observational properties of these relativistic tidal flares observed last year, and their evolution over the first year since their discovery.

  5. Nutrition for distance events.

    PubMed

    Burke, Louise M; Millet, Gregoire; Tarnopolsky, Mark A

    2007-01-01

    The goal of training is to prepare the distance athlete to perform at his or her best during major competitions. Whatever the event, nutrition plays a major role in the achievement of various factors that will see a runner or walker take the starting line in the best possible form. Everyday eating patterns must supply fuel and nutrients needed to optimize their performance during training sessions and to recover quickly afterwards. Carbohydrate and fluid intake before, during, and after a workout may help to reduce fatigue and enhance performance. Recovery eating should also consider issues for adaptation and the immune system that may involve intakes of protein and some micronutrients. Race preparation strategies should include preparation of adequate fuel stores, including carbohydrate loading for prolonged events such as the marathon or 50-km walk. Fluid and carbohydrate intake during races lasting an hour or more should also be considered. Sports foods and supplements of value to distance athletes include sports drinks and liquid meal supplements to allow nutrition goals to be achieved when normal foods are not practical. While caffeine is an ergogenic aid of possible value to distance athletes, most other supplements are of minimal benefit.

  6. Solar Eruptive Events

    NASA Technical Reports Server (NTRS)

    Holman, Gordon D.

    2012-01-01

    It s long been known that the Sun plays host to the most energetic explosions in the solar system. But key insights into the forms that energy takes have only recently become available. Solar flares have been phenomena of both academic and practical interest since their discovery in 1859. From the academic point of view, they are the nearest events for studying the explosive release of energy in astrophysical magnetized plasmas. From the practical point of view, they disrupt communication channels on Earth, from telegraph communications in 1859 to radio and television signals today. Flares also wreak havoc on the electrical power grid, satellite operations, and GPS signals, and energetic charged particles and radiation are dangerous to passengers on high-altitude polar flights and to astronauts. Flares are not the only explosive phenomena on the Sun. More difficult to observe but equally energetic are the large coronal mass ejections (CMEs), the ejection of up to ten billion tons of magnetized plasma into the solar wind at speeds that can exceed 1000 km/s. CMEs are primarily observed from the side, with coronagraphs that block out the bright disk of the Sun and lower solar atmosphere so that light scattered from the ejected mass can be seen. Major geomagnetic storms are now known to arise from the interaction of CMEs with Earth's magnetosphere. Solar flares are observed without CMEs, and CMEs are observed without flares. The two phenomena often occur together, however, and almost always do in the case of large flares and fast CMEs. The term solar eruptive event refers to the combination of a flare and a CME. Solar eruptive events generate a lot of heat: They can heat plasma to temperatures as high at 50 million Kelvin, producing radiation across the electromagnetic spectrum. But that s not all. A fascinating aspect of solar eruptive events is the acceleration of electrons and ions to suprathermal often relativistic energies. The accelerated particles are primarily

  7. Initiation of Meiotic Recombination in Mammals

    PubMed Central

    Kumar, Rajeev; de Massy, Bernard

    2010-01-01

    Meiotic recombination is initiated by the induction of programmed DNA double strand breaks (DSBs). DSB repair promotes homologous interactions and pairing and leads to the formation of crossovers (COs), which are required for the proper reductional segregation at the first meiotic division. In mammals, several hundred DSBs are generated at the beginning of meiotic prophase by the catalytic activity of SPO11. Currently it is not well understood how the frequency and timing of DSB formation and their localization are regulated. Several approaches in humans and mice have provided an extensive description of the localization of initiation events based on CO mapping, leading to the identification and characterization of preferred sites (hotspots) of initiation. This review presents the current knowledge about the proteins known to be involved in this process, the sites where initiation takes place, and the factors that control hotspot localization. PMID:24710101

  8. Augmenting Probabilistic Risk Assesment with Malevolent Initiators

    SciTech Connect

    Curtis Smith; David Schwieder

    2011-11-01

    As commonly practiced, the use of probabilistic risk assessment (PRA) in nuclear power plants only considers accident initiators such as natural hazards, equipment failures, and human error. Malevolent initiators are ignored in PRA, but are considered the domain of physical security, which uses vulnerability assessment based on an officially specified threat (design basis threat). This paper explores the implications of augmenting and extending existing PRA models by considering new and modified scenarios resulting from malevolent initiators. Teaming the augmented PRA models with conventional vulnerability assessments can cost-effectively enhance security of a nuclear power plant. This methodology is useful for operating plants, as well as in the design of new plants. For the methodology, we have proposed an approach that builds on and extends the practice of PRA for nuclear power plants for security-related issues. Rather than only considering 'random' failures, we demonstrated a framework that is able to represent and model malevolent initiating events and associated plant impacts.

  9. How synchronous are neogene marine plankton events?

    NASA Astrophysics Data System (ADS)

    Spencer-Cervato, Cinzia; Thierstein, Hans R.; Lazarus, David B.; Beckmann, Jean-Pierre

    1994-10-01

    An electronic supplement of this material may be obtained on adiskette or Anonymous FTP from KOSMOS.AGU.ORG. (LOGIN toAGU's FTP account using ANONYMOUS as the username andGUEST as the password. Go to the right directory by typing CDAPEND. Type LS to see what files are available. Type GET and thename of the file to get it. Finally, type EXIT to leave the system.)(Paper 94PA01456, How synchronous are Neogene marine planktonevents?, by C. Spencer-Cervato, H. R. Thierstein, D. B. Lazarus, andJ-P Beckmann). Diskette may be ordered from American GeophysicalUnion, 2000 Florida Avenue, N.W., Washington, DC 20009; $15.00.Payment must accompany order.We analyzed the synchrony and diachrony of commonly used Neogene biostratigraphic events from data published in the Initial Reports of the Deep Sea Drilling Project (DSDP) and in the Proceedings of the Ocean Drilling Program (ODP). On the basis of the combined biostratigraphic and magnetostratigraphic evidence, new Neogene age models were constructed for 35 globally distributed DSDP and ODP holes. Biostratigraphic events from the four major plankton groups (calcareous nannofossils, diatoms, planktonic foraminifera, and radiolarians) were compiled from DSDP and ODP reports. After the elimination of possible sources of error such as stratigraphic hiatuses and reworking of specimens, 124 biostratigraphic events that occurred in at least four holes were analyzed in detail: for each event a biochronologic age estimate was derived by projection of the depth of the event onto the line of correlation of each hole, and from these a global mean age for each event was calculated, together with its standard deviation. Average standard deviations for event ages by fossil group are: calcareous nannofossil first appearance datums (FADs): 0.57 m.y. (21 events), calcareous nannofossil last appearance datums (LADs): 0.60 m.y. (25 events), diatom FADs: 0.57 m.y. (7 events), diatom LADs: 0.85 m.y. (14 events), planktonic foraminifera FADs: 0.88 m

  10. Brane decay and an initial spacelike singularity.

    PubMed

    Kawai, Shinsuke; Keski-Vakkuri, Esko; Leigh, Robert G; Nowling, Sean

    2006-01-27

    We present a novel string theory scenario where matter in a spacetime originates from a decaying brane at the origin of time. The decay could be considered as a big-bang-like event at X0=0. The closed string interpretation is a time-dependent spacetime with a semi-infinite time direction, with the initial energy of the brane converted into energy flux from the origin. The open string interpretation can be viewed as a string theoretic nonsingular initial condition.

  11. Comments on event driven animation

    NASA Technical Reports Server (NTRS)

    Gomez, Julian E.

    1987-01-01

    Event driven animation provides a general method of describing controlling values for various computer animation techniques. A definition and comments are provided on genralizing motion description with events. Additional comments are also provided about the implementation of twixt.

  12. Picosecond Chemical and Biological Events.

    ERIC Educational Resources Information Center

    Rentzepis, P. M.

    1978-01-01

    Describes a currently used picosecond spectroscopy system capable of reliably recording picosecond events. Two areas of picosecond research are discussed: one concerns the interaction of electrons in fluids; the second, the primary events in vision. (Author/HM)

  13. Cells anticipate periodic events

    NASA Astrophysics Data System (ADS)

    Nakagaki, Toshiyuki

    2009-03-01

    We show that an amoeboid organism can anticipate the timing of periodic events. The plasmodium of the true slime mold Physarum polycephalum moves rapidly under favourable conditions, but stops moving when transferred to less-favourable conditions. Plasmodia exposed to unfavourable conditions, presented in three consecutive pulses at constant intervals, reduced their locomotive speed in response to each episode. When subsequently subjected to favourable conditions, the plasmodia spontaneously reduced their locomotive speed at the time point when the next unfavourable episode would have occurred. This implied anticipation of impending environmental change. After this behaviour had been evoked several times, the locomotion of the plasmodia returned to normal; however, the anticipatory response could subsequently be induced by a single unfavourable pulse, implying recall of the memorized periodicity. We explored the mechanisms underlying these behaviours from a dynamical systems perspective. Our results hint at the cellular origins of primitive intelligence and imply that simple dynamics might be sufficient to explain its emergence.

  14. [Mass casualty events].

    PubMed

    Guła, Przemysław; Hładki, Waldemar; Brongel, Leszek

    2006-01-01

    Authors present problems concerning mass--casualty accidents, specificity of action rescue-system on different levels of co-operation, kind of segregation of victims and efficiency of the medical rescue system in Poland. Attention has been paid to the continuous instructions and education of life-saving services, preferably by simulation of events without earlier information of the interested. It is necessary to establish and abide official dependence by the rules of co-operation of components of life-saving system. A separate problem is the implementation of rescue--activities in special situations: nuclear, biological and chemical contamination, and with very important safety measures for people taking part in rescue action.

  15. Event counting alpha detector

    DOEpatents

    Bolton, Richard D.; MacArthur, Duncan W.

    1996-01-01

    An electrostatic detector for atmospheric radon or other weak sources of alpha radiation. In one embodiment, nested enclosures are insulated from one another, open at the top, and have a high voltage pin inside and insulated from the inside enclosure. An electric field is produced between the pin and the inside enclosure. Air ions produced by collision with alpha particles inside the decay volume defined by the inside enclosure are attracted to the pin and the inner enclosure. With low alpha concentrations, individual alpha events can be measured to indicate the presence of radon or other alpha radiation. In another embodiment, an electrical field is produced between parallel plates which are insulated from a single decay cavity enclosure.

  16. Event counting alpha detector

    DOEpatents

    Bolton, R.D.; MacArthur, D.W.

    1996-08-27

    An electrostatic detector is disclosed for atmospheric radon or other weak sources of alpha radiation. In one embodiment, nested enclosures are insulated from one another, open at the top, and have a high voltage pin inside and insulated from the inside enclosure. An electric field is produced between the pin and the inside enclosure. Air ions produced by collision with alpha particles inside the decay volume defined by the inside enclosure are attracted to the pin and the inner enclosure. With low alpha concentrations, individual alpha events can be measured to indicate the presence of radon or other alpha radiation. In another embodiment, an electrical field is produced between parallel plates which are insulated from a single decay cavity enclosure. 6 figs.

  17. Autonomous aircraft initiative study

    NASA Technical Reports Server (NTRS)

    Hewett, Marle D.

    1991-01-01

    The results of a consulting effort to aid NASA Ames-Dryden in defining a new initiative in aircraft automation are described. The initiative described is a multi-year, multi-center technology development and flight demonstration program. The initiative features the further development of technologies in aircraft automation already being pursued at multiple NASA centers and Department of Defense (DoD) research and Development (R and D) facilities. The proposed initiative involves the development of technologies in intelligent systems, guidance, control, software development, airborne computing, navigation, communications, sensors, unmanned vehicles, and air traffic control. It involves the integration and implementation of these technologies to the extent necessary to conduct selected and incremental flight demonstrations.

  18. Collaborative Procurement Initiative

    EPA Pesticide Factsheets

    GPP's Clean Energy Collaborative Procurement Initiative provides a platform for deploying clean energy technologies across multiple government and educational organizations for maximum impact on installed solar system capacity and local economic activity.

  19. About the RAS Initiative

    Cancer.gov

    The RAS Initiative, a "hub and spoke" model, connects researchers to better understand and target the more than 30% of cancers driven by mutations in RAS genes. Includes oversight and contact information.

  20. RAS Initiative - Community Outreach

    Cancer.gov

    Through community and technical collaborations, workshops and symposia, and the distribution of reference reagents, the RAS Initiative seeks to increase the sharing of knowledge and resources essential to defeating cancers caused by mutant RAS genes.

  1. Advanced Concepts Research Initiative

    EPA Science Inventory

    This initiative is investigating various approaches to controlling and treating wet-weather flow (WWF) discharges in the urban watershed. WWF, including combined sewer overflow (CSO), sanitary sewer overflow (SSO) and stormwater discharges are leading causes of receiving water q...

  2. The RAS Initiative

    Cancer.gov

    NCI established the RAS Initiative to explore innovative approaches for attacking the proteins encoded by mutant forms of RAS genes and to ultimately create effective, new therapies for RAS-related cancers.

  3. Project Matching Initiative

    EPA Pesticide Factsheets

    The Green Power Partnership's Project Matching initiative works to connect green power users with new, not-yet-built renewable energy projects that may align with their energy, environmental, and financial objectives.

  4. PESP Landscaping Initiative

    EPA Pesticide Factsheets

    Landscaping practices can positively or negatively affect local environments and human health. The Landscaping Initiative seeks to enhance benefits of landscaping while reducing need for pesticides, fertilizers, etc., by working with partners.

  5. Initial Symptoms of ALS

    MedlinePlus

    ... Chapters Certified Centers and Clinics Support Groups About ALS About Us Our Research In Your Community Advocate ... Diagnosis En español Symptoms The initial symptoms of ALS can be quite varied in different people. One ...

  6. Midwest Clean Diesel Initiative

    EPA Pesticide Factsheets

    The Midwest Clean Diesel Initiative (MCDI) is a collaboration of federal, state and local agencies, along with communities, non-profit organizations and private companies working together by reducing exposure to emissions from diesel engines

  7. Piezoelectrically Initiated Pyrotechnic Igniter

    NASA Technical Reports Server (NTRS)

    Quince, Asia; Dutton, Maureen; Hicks, Robert; Burnham, Karen

    2013-01-01

    This innovation consists of a pyrotechnic initiator and piezoelectric initiation system. The device will be capable of being initiated mechanically; resisting initiation by EMF, RF, and EMI (electromagnetic field, radio frequency, and electromagnetic interference, respectively); and initiating in water environments and space environments. Current devices of this nature are initiated by the mechanical action of a firing pin against a primer. Primers historically are prone to failure. These failures are commonly known as misfires or hang-fires. In many cases, the primer shows the dent where the firing pin struck the primer, but the primer failed to fire. In devices such as "T" handles, which are commonly used to initiate the blowout of canopies, loss of function of the device may result in loss of crew. In devices such as flares or smoke generators, failure can result in failure to spot a downed pilot. The piezoelectrically initiated ignition system consists of a pyrotechnic device that plugs into a mechanical system (activator), which on activation, generates a high-voltage spark. The activator, when released, will strike a stack of electrically linked piezo crystals, generating a high-voltage, low-amperage current that is then conducted to the pyro-initiator. Within the initiator, an electrode releases a spark that passes through a pyrotechnic first-fire mixture, causing it to combust. The combustion of the first-fire initiates a primary pyrotechnic or explosive powder. If used in a "T" handle, the primary would ramp the speed of burn up to the speed of sound, generating a shock wave that would cause a high explosive to go "high order." In a flare or smoke generator, the secondary would produce the heat necessary to ignite the pyrotechnic mixture. The piezo activator subsystem is redundant in that a second stack of crystals would be struck at the same time with the same activation force, doubling the probability of a first strike spark generation. If the first

  8. Detectability of Discrete Event Systems with Dynamic Event Observation

    PubMed Central

    Shu, Shaolong; Lin, Feng

    2009-01-01

    Our previous work considers detectability of discrete event systems which is to determine the current state and subsequent states of a system based on event observation. We assume that event observation is static, that is, if an event is observable, then all its occurrences are observable. However, in practical systems such as sensor networks, event observation often needs to be dynamic, that is, the occurrences of same events may or may not be observable, depending on the state of the system. In this paper, we generalize static event observation into dynamic event observation and consider the detectability problem under dynamic event observation. We define four types of detectabilities. To check detectabilities, we construct the observer with exponential complexity. To reduce computational complexity, we can also construct a detector with polynomial complexity to check strong detectabilities. Dynamic event observation can be implemented in two possible ways: a passive observation and an active observation. For the active observation, we discuss how to find minimal event observation policies that preserve four types of detectabilities respectively. PMID:20161618

  9. Initial condition from the shadowed Glauber model

    NASA Astrophysics Data System (ADS)

    Chatterjee, Sandeep; Singh, Sushant K.; Ghosh, Snigdha; Hasanujjaman, Md; Alam, Jane; Sarkar, Sourav

    2016-07-01

    The two component Monte-Carlo Glauber model predicts a knee-like structure in the centrality dependence of elliptic flow v2 in Uranium + Uranium collisions at √{sNN} = 193 GeV. It also produces a strong anti-correlation between v2 and dNch / dy in the case of top ZDC events. However, none of these features have been observed in data. We address these discrepancies by including the effect of nucleon shadowing to the two component Monte-Carlo Glauber model. Apart from addressing successfully the above issues, we find that the nucleon shadow suppresses the event by event fluctuation of various quantities, e.g. ε2 which is in accordance with expectation from the dynamical models of initial condition based on gluon saturation physics.

  10. Sudden Event Recognition: A Survey

    PubMed Central

    Suriani, Nor Surayahani; Hussain, Aini; Zulkifley, Mohd Asyraf

    2013-01-01

    Event recognition is one of the most active research areas in video surveillance fields. Advancement in event recognition systems mainly aims to provide convenience, safety and an efficient lifestyle for humanity. A precise, accurate and robust approach is necessary to enable event recognition systems to respond to sudden changes in various uncontrolled environments, such as the case of an emergency, physical threat and a fire or bomb alert. The performance of sudden event recognition systems depends heavily on the accuracy of low level processing, like detection, recognition, tracking and machine learning algorithms. This survey aims to detect and characterize a sudden event, which is a subset of an abnormal event in several video surveillance applications. This paper discusses the following in detail: (1) the importance of a sudden event over a general anomalous event; (2) frameworks used in sudden event recognition; (3) the requirements and comparative studies of a sudden event recognition system and (4) various decision-making approaches for sudden event recognition. The advantages and drawbacks of using 3D images from multiple cameras for real-time application are also discussed. The paper concludes with suggestions for future research directions in sudden event recognition. PMID:23921828

  11. Event boundaries and memory improvement.

    PubMed

    Pettijohn, Kyle A; Thompson, Alexis N; Tamplin, Andrea K; Krawietz, Sabine A; Radvansky, Gabriel A

    2016-03-01

    The structure of events can influence later memory for information that is embedded in them, with evidence indicating that event boundaries can both impair and enhance memory. The current study explored whether the presence of event boundaries during encoding can structure information to improve memory. In Experiment 1, memory for a list of words was tested in which event structure was manipulated by having participants walk through a doorway, or not, halfway through the word list. In Experiment 2, memory for lists of words was tested in which event structure was manipulated using computer windows. Finally, in Experiments 3 and 4, event structure was manipulated by having event shifts described in narrative texts. The consistent finding across all of these methods and materials was that memory was better when the information was distributed across two events rather than combined into a single event. Moreover, Experiment 4 demonstrated that increasing the number of event boundaries from one to two increased the memory benefit. These results are interpreted in the context of the Event Horizon Model of event cognition.

  12. Event Structure and Cognitive Control

    ERIC Educational Resources Information Center

    Reimer, Jason F.; Radvansky, Gabriel A.; Lorsbach, Thomas C.; Armendarez, Joseph J.

    2015-01-01

    Recently, a great deal of research has demonstrated that although everyday experience is continuous in nature, it is parsed into separate events. The aim of the present study was to examine whether event structure can influence the effectiveness of cognitive control. Across 5 experiments we varied the structure of events within the AX-CPT by…

  13. Stimuli, Reinforcers, and Private Events

    ERIC Educational Resources Information Center

    Nevin, John A.

    2008-01-01

    Radical behaviorism considers private events to be a part of ongoing observable behavior and to share the properties of public events. Although private events cannot be measured directly, their roles in overt action can be inferred from mathematical models that relate private responses to external stimuli and reinforcers according to the same…

  14. Contingency Analysis of Cascading Line Outage Events

    SciTech Connect

    Thomas L Baldwin; Magdy S Tawfik; Miles McQueen

    2011-03-01

    As the US power systems continue to increase in size and complexity, including the growth of smart grids, larger blackouts due to cascading outages become more likely. Grid congestion is often associated with a cascading collapse leading to a major blackout. Such a collapse is characterized by a self-sustaining sequence of line outages followed by a topology breakup of the network. This paper addresses the implementation and testing of a process for N-k contingency analysis and sequential cascading outage simulation in order to identify potential cascading modes. A modeling approach described in this paper offers a unique capability to identify initiating events that may lead to cascading outages. It predicts the development of cascading events by identifying and visualizing potential cascading tiers. The proposed approach was implemented using a 328-bus simplified SERC power system network. The results of the study indicate that initiating events and possible cascading chains may be identified, ranked and visualized. This approach may be used to improve the reliability of a transmission grid and reduce its vulnerability to cascading outages.

  15. Tempering the reactivities of postulated α-oxo gold carbenes using bidentate ligands: implication of tricoordinated gold intermediates and the development of an expedient bimolecular assembly of 2,4-disubstituted oxazoles.

    PubMed

    Luo, Yingdong; Ji, Kegong; Li, Yuxue; Zhang, Liming

    2012-10-24

    2,4-Oxazole is an important structural motif in various natural products. An efficient modular synthesis of this structure has been achieved via a [3 + 2] annulation between a terminal alkyne and a carboxamide using a gold-catalyzed oxidation strategy. The postulated reactive intermediate, a terminal α-oxo gold carbene, previously known to be highly electrophilic and hence unlikely to be trapped by stoichiometric external nucleophiles, is coerced to react smoothly with the carboxamide en route to the oxazole ring by a P,N- or P,S-bidentate ligand such as Mor-DalPhos; in stark contrast, often-used ligands such as monodentate phosphines and N-heterocyclic carbenes are totally ineffective. The role of these bidentate phosphines in this reaction is attributed to the formation of a tricoordinated gold carbene intermediate, which is less electrophilic and hence more chemoselective when reacting with nucleophiles. The success in using bidentate phosphine ligands to temper the reactivities of in situ-generated gold carbenes is likely to open many new opportunities to apply oxidative gold catalysis to the development of novel methods, and the implication of tricoordinated gold intermediates in homogeneous gold catalysis should stimulate further advances in gold catalysis.

  16. Revisiting Shock Initiation Modeling of Homogeneous Explosives

    NASA Astrophysics Data System (ADS)

    Partom, Yehuda

    2013-04-01

    Shock initiation of homogeneous explosives has been a subject of research since the 1960s, with neat and sensitized nitromethane as the main materials for experiments. A shock initiation model of homogeneous explosives was established in the early 1960s. It involves a thermal explosion event at the shock entrance boundary, which develops into a superdetonation that overtakes the initial shock. In recent years, Sheffield and his group, using accurate experimental tools, were able to observe details of buildup of the superdetonation. There are many papers on modeling shock initiation of heterogeneous explosives, but there are only a few papers on modeling shock initiation of homogeneous explosives. In this article, bulk reaction reactive flow equations are used to model homogeneous shock initiation in an attempt to reproduce experimental data of Sheffield and his group. It was possible to reproduce the main features of the shock initiation process, including thermal explosion, superdetonation, input shock overtake, overdriven detonation after overtake, and the beginning of decay toward Chapman-Jouget (CJ) detonation. The time to overtake (TTO) as function of input pressure was also calculated and compared to the experimental TTO.

  17. EVENT PLANNING USING FUNCTION ANALYSIS

    SciTech Connect

    Lori Braase; Jodi Grgich

    2011-06-01

    Event planning is expensive and resource intensive. Function analysis provides a solid foundation for comprehensive event planning (e.g., workshops, conferences, symposiums, or meetings). It has been used at Idaho National Laboratory (INL) to successfully plan events and capture lessons learned, and played a significant role in the development and implementation of the “INL Guide for Hosting an Event.” Using a guide and a functional approach to planning utilizes resources more efficiently and reduces errors that could be distracting or detrimental to an event. This integrated approach to logistics and program planning – with the primary focus on the participant – gives us the edge.

  18. The Chelyabinsk event

    NASA Astrophysics Data System (ADS)

    Borovička, Jiří

    2016-10-01

    On February 15, 2013, 3:20 UT, an asteroid of the size of about 19 meters and mass of 12,000 metric tons entered the Earth's atmosphere unexpectedly near the border of Kazakhstan and Russia. It was the largest confirmed Earth impactor since the Tunguska event in 1908. The body moved approximately westwards with a speed of 19 km s-1, on a trajectory inclined 18 degrees to the surface, creating a fireball of steadily increasing brightness. Eleven seconds after the first sightings, the fireball reached its maximum brightness. At that point, it was located less than 40 km south from Chelyabinsk, a Russian city of population more than one million, at an altitude of 30 km. For people directly underneath, the fireball was 30 times brighter than the Sun. The cosmic body disrupted into fragments; the largest of them was visible for another five seconds before it disappeared at an altitude of 12.5 km, when it was decelerated to 3 km s-1. Fifty six second later, that ~600 kg fragment landed in Lake Chebarkul and created a 8 m wide hole in the ice. Small meteorites landed in an area 80 km long and several km wide and caused no damage. The meteorites were classified as LL ordinary chondrites and were interesting by the presence of two phases, light and dark. More material remained, however, in the atmosphere forming a dust trail up to 2 km wide and extending along the fireball trajectory from altitude 18 to 70 km. The dust then circled the Earth within few days and formed a ring around the northern hemisphere. In Chelyabinsk and its surroundings a very strong blast wave arrived 90 - 150 s after the fireball passage (depending on location). The wave was produced by the supersonic flight of the body and broke ~10% of windows in Chelyabinsk (~40% of buildings were affected). More than 1600 people were injured, mostly from broken glass. The whole event was well documented by video cameras, seismic and infrasonic records, and satellite observations. The total energy was 500 kT TNT

  19. The Chelyabinsk event

    NASA Astrophysics Data System (ADS)

    Borovička, Jiri

    2015-08-01

    On February 15, 2013, 3:20 UT, an asteroid of the size of about 19 meters and mass of 12,000 metric tons entered the Earth's atmosphere unexpectedly near the border of Kazakhstan and Russia. It was the largest confirmed Earth impactor since the Tunguska event in 1908. The body moved approximately westwards with a speed of 19 km/s, on a trajectory inclined 18 degrees to the surface, creating a fireball of steadily increasing brightness. Eleven seconds after the first sightings, the fireball reached its maximum brightness. At that point, it was located less than 40 km south from Chelyabinsk, a Russian city of population more than one million, at an altitude of 30 km. For people directly underneath, the fireball was 30 times brighter than the Sun. The cosmic body disrupted into fragments; the largest of them was visible for another five seconds before it disappeared at an altitude of 12.5 km, when it was decelerated to 3 km/s. Fifty six second later, that ~ 600 kg fragment landed in Lake Chebarkul and created an 8 m wide hole in the ice. More material remained, however, in the atmosphere forming a dust trail up to 2 km wide and extending along the fireball trajectory from altitude 18 to 70 km. People observing the dust trail from Chelyabinsk and other places were surprised by the arrival of a very strong blast wave 90 - 150 s after the fireball passage (depending on location). The wave, produced by the supersonic flight of the body, broke ~10% of windows in Chelyabinsk (~40% of buildings were affected). More than 1600 people were injured, mostly from broken glass. Small meteorites landed in an area 60 km long and several km wide and caused no damage. The meteorites were classified as LL ordinary chondrites and were interesting by the presence of two phases, light and dark. The dust left in the atmosphere circled the Earth within few days and formed a ring around the northern hemisphere.The whole event was well documented by video cameras, seismic and infrasonic

  20. The Debris Streams from Tidal Disruption Events

    NASA Astrophysics Data System (ADS)

    Coughlin, Eric

    2016-01-01

    When a star comes within a critical distance of a supermassive black hole, the tidal force exerted by the hole overcomes the stellar self-gravity. The star is subsequently torn apart, creating a stream of tidally-shredded debris that initially recedes from the hole, eventually returns to pericenter, forms an accretion disk and generates a highly luminous event that can sometimes be accompanied by the production of relativistic jets. This entire process is known as a tidal disruption event (TDE), and dozens of these events have already been observed. I will discuss my most recent work that has analyzed the tidal disruption process, and in particular I will focus on the results of numerical and analytical investigations that show that the streams of debris produced during TDEs can be gravitationally unstable. Specifically, I will describe how compressive motions augment the importance of self-gravity not long after the star is disrupted, resulting in the fragmentation of the debris stream into small-scale clumps. These findings will be discussed in the context of the observational signatures of tidal disruption events, and I will also relate these results to my past investigations concerning accretion disk formation and jet launching during TDEs.

  1. Progress on Simulating the Initiation of Vacuum Insulator Flashover

    DTIC Science & Technology

    2009-06-01

    of a +45° angled insulator as well as pictures demonstrating anode and cathode initiated flashover events [2]. In order to focus our attention on...Progress on Simulating the Initiation of Vacuum Insulator Flashover M.P. Perkins, T.L. Houck, J.B. Javedani, G.E. Vogtlin, D.A. Goerz Lawrence...In this article we will discuss physics models that have been implemented in a PIC code to better understand the initiation of flashover . The PIC

  2. Semantic Event Correlation Using Ontologies

    NASA Astrophysics Data System (ADS)

    Moser, Thomas; Roth, Heinz; Rozsnyai, Szabolcs; Mordinyi, Richard; Biffl, Stefan

    Complex event processing (CEP) is a software architecture paradigm that aims at low latency, high throughput, and quick adaptability of applications for supporting and improving event-driven business processes. Events sensed in real time are the basic information units on which CEP applications operate and react in self-contained decision cycles based on defined processing logic and rules. Event correlation is necessary to relate events gathered from various sources for detecting patterns and situations of interest in the business context. Unfortunately, event correlation has been limited to syntactically identical attribute values instead of addressing semantically equivalent attribute meanings. Semantic equivalence is particularly relevant if events come from organizations that use different terminologies for common concepts.

  3. 77 FR 39453 - Special Local Regulations for Marine Events; Temporary Change of Dates for Recurring Marine...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ... SECURITY Coast Guard 33 CFR Part 100 RIN 1625--AA08 Special Local Regulations for Marine Events; Temporary Change of Dates for Recurring Marine Events in the Fifth Coast Guard District, Bogue Sound; Morehead City... regulation of a recurring marine event in the Fifth Coast Guard District. The proposed rule was initiated...

  4. Research on diabatic initialization

    NASA Technical Reports Server (NTRS)

    Kasahara, Akira

    1990-01-01

    The objective of this research project is to contribute to improvement in the synoptic analyses in the tropics for numerical weather prediction and climate research. In addition to a prediction model, four dimensional data assimilation systems have two principal components. One is objective analysis and the other is initialization. Various methods of objective analysis are designed primarily to analyze the mass and rotational wind fields. Methods of initialization are developed to obtain the irrotational wind and its associated vertical velocity field which are balanced with the mass field and free from meteorological noise. There are essentially three approaches to the problem of initialization: quasi-geostrophic theory, bounded derivative method and nonlinear normal mode method. In the midlatitudes, these approaches generally produce satisfactory results even without diabatic effects for large-scale motions. In the tropics, the situation is quite different from that in the midlatitudes. Because of a small magnitude of the Coriolis parameter and a weak horizontal temperature gradient in the tropics, any method of initialization must incorporate diabatic effects. In fact, it can be said that understanding the problem of diabatic initialization is the key to improving the analysis and weather forecasting in the tropics.

  5. The mid-Carboniferous conodont extinction event

    SciTech Connect

    Nemirovskaya, T.I. ); Nigmadzhanov, I.M. )

    1992-01-01

    The biotic turnover defining the mid-Carboniferous boundary was a consequence of a worldwide eustatic event that lowered sea level, interrupted sedimentation, and greatly reduced taxonomic diversity in marine basins. The event, which affected ammonoids, foraminifers, corals, and crinoids, nearly eliminated Lower Carboniferous conodonts. Reorganization of conodonts around the mid-Carboniferous boundary occurred in four stages: (1) destabilization of assemblages and radiation of new species of the dominant genus Gnathodus at the beginning of the ecological crisis; (2) appearance of Upper Carboniferous genera, Declinognathodus and Idiognathoides, and initial attempts to adapt to new environments; (3) mass extinction of typical Lower Carboniferous gnathodids and paragnathodids; and (4) start of adaptive radiation of declinognathodids and idiognathoidids.

  6. Research on diabatic initialization

    NASA Technical Reports Server (NTRS)

    Kashara, Akira

    1993-01-01

    The objective of this research is to contribute to the improvement of the analyses of irrotational wind and moisture fields in the tropics through advancement in the technique of initialization, incorporating diabatic effects and use of satellite-derived, radiometric imagery data that are not used currently by operational centers. Significant accomplishments during the period of May 1991 - April 1992 in research involving the following are presented: impact of tropical initialization upon the spin-up of precipitation forecasts; and a unified approach to diabatic initialization for improvement in the analysis of divergence and water vapor fields in the tropics. Focus of current research and plans for next year are discussed with respect to the topics of controlling the precipitation over shoot during the early part of a numerical forecast and the use of satellite imagery data for improvement of the tropical analysis.

  7. Civil space technology initiative

    NASA Technical Reports Server (NTRS)

    1990-01-01

    The Civil Space Technology Initiative (CSTI) is a major, focused, space technology program of the Office of Aeronautics, Exploration and Technology (OAET) of NASA. The program was initiated to advance technology beyond basic research in order to expand and enhance system and vehicle capabilities for near-term missions. CSTI takes critical technologies to the point at which a user can confidently incorporate the new or expanded capabilities into relatively near-term, high-priority NASA missions. In particular, the CSTI program emphasizes technologies necessary for reliable and efficient access to and operation in Earth orbit as well as for support of scientific missions from Earth orbit.

  8. Shock initiation of nitromethane

    SciTech Connect

    Yoo, C.S.; Holmes, N.C.

    1993-12-31

    The shock initiation processes of nitromethane have been examined by using a fast time-resolved emission spectroscopy at a two-stage gas gun. a broad, but strong emission has been observed in a spectral range between 350 and 700 nm from shocked nitromethane above 9 GPa. The temporal profile suggests that shocked nitromethane detonates through three characteristic periods, namely an induction period, a hock initiation period, and a thermal explosion period. This paper discusses temporal and chemical characteristics of these periods and present the temperature of the shock-detonating nitromethane at pressures between 9 and 15 GPa.

  9. Research on diabatic initialization

    NASA Technical Reports Server (NTRS)

    Kasahara, Akira

    1991-01-01

    The objective was to contribute to the improvement of the analyses of irrotational wind and moisture fields in the trophics through advancement in the technique of initialization by incorporating diabatic effects. Significant accomplishments made during the period May 1990 to April 1991 in the following areas are presented: (1) estimation of the uncertainty of daily synoptic analyses in the tropics; (2) normal modes of Laplace's tidal equations for zonal wavenumber zero; and (3) tropical initialization to ameliorate the spin-up problem of precipitation forecasts. The focus of current research and plans for next year are also presented.

  10. STI Program Multimedia Initiative

    NASA Technical Reports Server (NTRS)

    Cotter, Gladys A.; Kaye, Karen

    1993-01-01

    This paper relates the experience of the NASA Scientific and Technical Information Program in introducing multimedia within the STI Program framework. A discussion of multimedia technology is included to provide context for the STI Program effort. The STI Program's Multimedia Initiative is discussed in detail. Parallels and differences between multimedia and traditional information systems project development are highlighted. Challenges faced by the program in initiating its multimedia project are summarized along with lessons learned. The paper concludes with a synopsis of the benefits the program hopes to provide its users through the introduction of multimedia illustrated by examples of successful multimedia projects.

  11. Temporal distortion in the perception of actions and events.

    PubMed

    Yabe, Yoshiko; Dave, Hemangi; Goodale, Melvyn A

    2017-01-01

    In everyday life, actions and sensory events occur in complex sequences, with events triggering actions that in turn give rise to additional events and so on. Earlier work has shown that a sensory event that is triggered by a voluntary action is perceived to have occurred earlier in time than an identical event that is not triggered by an action. In other words, events that are believed to be caused by our actions are drawn forward in time towards our actions. Similarly, when a sensory event triggers an action, that event is again drawn in time towards the action and is thus perceived to have occurred later than it really did. This alteration in time perception serves to bind together events and actions that are causally linked. It is not clear, however, whether or not the perceived timing of a sensory event embedded within a longer series of actions and sensory events is also temporally bound to the actions in that sequence. In the current study, we measured the temporal binding in sequences consisting of two simple dyads of event-action and action-event in a series of manual action tasks: an event-action-event triad (Experiment 1) and an action-event-action triad (Experiment 2). Auditory tones either triggered an action or were presented 250ms after an action was performed. To reduce the influence of sensory events other than the tone, such as a noise associated with pressing a key on a keyboard, we used an optical sensor to detect hand movements where no contact was made with a surface. In Experiment 1, there appeared to be no change in the perceived onset of an auditory tone when the onset of that tone followed a hand movement and then the tone triggered a second hand movement. It was as if the temporal binding between the action and the tone and then the tone and the subsequent action summed algebraically and cancelled each other out. In Experiment 2, both the perceived onset of an initial tone which triggered an action and the perceived onset of a second tone

  12. Events and event identity: under-explored topics in nursing.

    PubMed

    Lipscomb, Martin

    2010-04-01

    Theoretic interest in the nature of events and event identity is apparent across a wide range of fields. However, this interest has not yet made itself known in nursing. In this paper, it is asserted that nurse theoreticians and researchers should consider the problematic of events and event identity. It is suggested that engagement with these issues is important because the manner in which this component of explanation is integrated into argument has concrete implications for our understanding of healthcare practice. Indeed, refusal to engage with such issues may jeopardize explanatory coherence.

  13. Event Segmentation Improves Event Memory up to One Month Later.

    PubMed

    Flores, Shaney; Bailey, Heather R; Eisenberg, Michelle L; Zacks, Jeffrey M

    2017-04-06

    When people observe everyday activity, they spontaneously parse it into discrete meaningful events. Individuals who segment activity in a more normative fashion show better subsequent memory for the events. If segmenting events effectively leads to better memory, does asking people to attend to segmentation improve subsequent memory? To answer this question, participants viewed movies of naturalistic activity with instructions to remember the activity for a later test, and in some conditions additionally pressed a button to segment the movies into meaningful events or performed a control condition that required button-pressing but not attending to segmentation. In 5 experiments, memory for the movies was assessed at intervals ranging from immediately following viewing to 1 month later. Performing the event segmentation task led to superior memory at delays ranging from 10 min to 1 month. Further, individual differences in segmentation ability predicted individual differences in memory performance for up to a month following encoding. This study provides the first evidence that manipulating event segmentation affects memory over long delays and that individual differences in event segmentation are related to differences in memory over long delays. These effects suggest that attending to how an activity breaks down into meaningful events contributes to memory formation. Instructing people to more effectively segment events may serve as a potential intervention to alleviate everyday memory complaints in aging and clinical populations. (PsycINFO Database Record

  14. Tidal disruption event demographics

    NASA Astrophysics Data System (ADS)

    Kochanek, C. S.

    2016-09-01

    We survey the properties of stars destroyed in tidal disruption events (TDEs) as a function of black hole (BH) mass, stellar mass and evolutionary state, star formation history and redshift. For M_{BH} ≲ 10^7 M_{⊙}, the typical TDE is due to a M* ˜ 0.3 M⊙ M-dwarf, although the mass function is relatively flat for M_{ast } ≲ M_{⊙}. The contribution from older main-sequence stars and sub-giants is small but not negligible. From MBH ≃ 107.5-108.5 M⊙, the balance rapidly shifts to higher mass stars and a larger contribution from evolved stars, and is ultimately dominated by evolved stars at higher BH masses. The star formation history has little effect until the rates are dominated by evolved stars. TDE rates should decline very rapidly towards higher redshifts. The volumetric rate of TDEs is very high because the BH mass function diverges for low masses. However, any emission mechanism which is largely Eddington-limited for low BH masses suppresses this divergence in any observed sample and leads to TDE samples dominated by MBH ≃ 106.0-107.5 M⊙ BHs with roughly Eddington peak accretion rates. The typical fall-back time is relatively long, with 16 per cent having tfb < 10-1 yr (37 d), and 84 per cent having longer time-scales. Many residual rate discrepancies can be explained if surveys are biased against TDEs with these longer tfb, which seems very plausible if tfb has any relation to the transient rise time. For almost any BH mass function, systematic searches for fainter, faster time-scale TDEs in smaller galaxies, and longer time-scale TDEs in more massive galaxies are likely to be rewarded.

  15. Significant Tsunami Events

    NASA Astrophysics Data System (ADS)

    Dunbar, P. K.; Furtney, M.; McLean, S. J.; Sweeney, A. D.

    2014-12-01

    Tsunamis have inflicted death and destruction on the coastlines of the world throughout history. The occurrence of tsunamis and the resulting effects have been collected and studied as far back as the second millennium B.C. The knowledge gained from cataloging and examining these events has led to significant changes in our understanding of tsunamis, tsunami sources, and methods to mitigate the effects of tsunamis. The most significant, not surprisingly, are often the most devastating, such as the 2011 Tohoku, Japan earthquake and tsunami. The goal of this poster is to give a brief overview of the occurrence of tsunamis and then focus specifically on several significant tsunamis. There are various criteria to determine the most significant tsunamis: the number of deaths, amount of damage, maximum runup height, had a major impact on tsunami science or policy, etc. As a result, descriptions will include some of the most costly (2011 Tohoku, Japan), the most deadly (2004 Sumatra, 1883 Krakatau), and the highest runup ever observed (1958 Lituya Bay, Alaska). The discovery of the Cascadia subduction zone as the source of the 1700 Japanese "Orphan" tsunami and a future tsunami threat to the U.S. northwest coast, contributed to the decision to form the U.S. National Tsunami Hazard Mitigation Program. The great Lisbon earthquake of 1755 marked the beginning of the modern era of seismology. Knowledge gained from the 1964 Alaska earthquake and tsunami helped confirm the theory of plate tectonics. The 1946 Alaska, 1952 Kuril Islands, 1960 Chile, 1964 Alaska, and the 2004 Banda Aceh, tsunamis all resulted in warning centers or systems being established.The data descriptions on this poster were extracted from NOAA's National Geophysical Data Center (NGDC) global historical tsunami database. Additional information about these tsunamis, as well as water level data can be found by accessing the NGDC website www.ngdc.noaa.gov/hazard/

  16. Monolithic exploding foil initiator

    SciTech Connect

    Welle, Eric J; Vianco, Paul T; Headley, Paul S; Jarrell, Jason A; Garrity, J. Emmett; Shelton, Keegan P; Marley, Stephen K

    2012-10-23

    A monolithic exploding foil initiator (EFI) or slapper detonator and the method for making the monolithic EFI wherein the exploding bridge and the dielectric from which the flyer will be generated are integrated directly onto the header. In some embodiments, the barrel is directly integrated directly onto the header.

  17. The SEED Initiative

    ERIC Educational Resources Information Center

    Teich, Carolyn R.

    2011-01-01

    Committed to fulfilling the promise of the green economy, the American Association of Community Colleges (AACC) launched the Sustainability Education and Economic Development (SEED) initiative (www.theseedcenter.org) in October 2010. The project advances sustainability and clean energy workforce development practices at community colleges by…

  18. Information Technology Initiative (Videorecording),

    DTIC Science & Technology

    Physical description: 1 VHS video; col.; sd.; mono.; standard playback sp.; 35:40 mins.; 1/2 in. In this video, Dr. Kurt Fisher, Deputy Director for Information Technology , introduces the Corporate Information Management (CIM) program and explains the following major technical initiatives: reuse/repositories; I-case; data administration; information technology architecture; software process improvement; standards.

  19. Mixed-Initiative Clustering

    ERIC Educational Resources Information Center

    Huang, Yifen

    2010-01-01

    Mixed-initiative clustering is a task where a user and a machine work collaboratively to analyze a large set of documents. We hypothesize that a user and a machine can both learn better clustering models through enriched communication and interactive learning from each other. The first contribution or this thesis is providing a framework of…

  20. Clean Energy Manufacturing Initiative

    SciTech Connect

    2013-04-01

    The initiative will strategically focus and rally EERE’s clean energy technology offices and Advanced Manufacturing Office around the urgent competitive opportunity for the United States to be the leader in the clean energy manufacturing industries and jobs of today and tomorrow.

  1. Kinesthetic Initial Training.

    ERIC Educational Resources Information Center

    Ostrom, Gladys

    1978-01-01

    The author's plans for Kinesthetic Initial Training (KIT), a system of interrelated subjects designed to teach handicapped and gifted students basic reading, writing, arithmetic, and grammar skills through the use of concrete materials, are described. KIT components are reviewed, and implications are considered for areas of psychomotor,…

  2. Envisioning Effective Laptop Initiatives

    ERIC Educational Resources Information Center

    Clausen, Jon M.; Britten, Jody; Ring, Gail

    2008-01-01

    A recent survey of 74 building-level school administrators in Indiana challenged many of the assumptions regarding 1:1 laptop initiatives and how 1:1 access would affect teaching and learning. It also revealed disturbing realities regarding instructional practices of teachers, as well as efforts to improve school technology integration. The intent…

  3. Ontario's Student Voice Initiative

    ERIC Educational Resources Information Center

    Courtney, Jean

    2014-01-01

    This article describes in some detail aspects of the Student Voice initiative funded and championed by Ontario's Ministry of Education since 2008. The project enables thousands of students to make their voices heard in meaningful ways and to participate in student-led research. Some students from grades 7 to 12 become members of the Student…

  4. Department-Initiated Change

    ERIC Educational Resources Information Center

    Watson, Anne; De Geest, Els

    2014-01-01

    This paper reports the activity of three secondary school mathematics departments in England in self-initiated states of change that led to overall improvements in students' achievements when compared to previous cohorts. This took place without intervention and without their participation in external projects. They provide examples of departments…

  5. Statistical initial orbit determination

    SciTech Connect

    Taff, L.G.; Belkin, B.; Schweiter, G.A.; Sommar, K. D.H. Wagner Associates, Inc., Paoli, PA )

    1992-02-01

    For the ballistic missile initial orbit determination problem in particular, the concept of 'launch folders' is extended. This allows to decouple the observational data from the initial orbit determination problem per se. The observational data is only used to select among the possible orbital element sets in the group of folders. Monte Carlo simulations using up to 7200 orbital element sets are described. The results are compared to the true orbital element set and the one a good radar would have been able to produce if collocated with the optical sensor. The simplest version of the new method routinely outperforms the radar initial orbital element set by a factor of two in future miss distance. In addition, not only can a differentially corrected orbital element set be produced via this approach - after only two measurements of direction - but also an updated, meaningful, six-dimensional covariance array for it can be calculated. This technique represents a significant advance in initial orbit determination for this problem, and the concept can easily be extended to minor planets and artificial satellites. 9 refs.

  6. Transformative Change Initiative

    ERIC Educational Resources Information Center

    Bragg, D. D.; Kirby, C.; Witt, M. A.; Richie, D.; Mix, S.; Feldbaum, M.; Liu, S.; Mason, M.

    2014-01-01

    The Transformative Change Initiative (TCI) is dedicated to assisting community colleges to scale up innovation in the form of guided pathways, programs of study, and evidence-based strategies to improve student outcomes and program, organization, and system performance. The impetus for TCI is the Trade Adjustment Assistance Community College and…

  7. Best Practices & Outstanding Initiatives

    ERIC Educational Resources Information Center

    Training, 2011

    2011-01-01

    In this article, "Training" editors recognize innovative and successful learning and development programs and practices. They share best practices from Automatic Data Processing, Inc., Farmers Insurance Group, FedEx Express, InterContinental Hotels Group, and Oakwood Temporary Housing. They also present the outstanding initiatives of EMD Serono,…

  8. Strategic Defense Initiative program

    SciTech Connect

    Conachan, F.C.

    1991-05-01

    This paper discusses the Strategic Defense Initiative (SDI) program. It summarizes the major programmatic and technological lessons learned from the SDI program over the past 7 years. It provides information on: past uses of SDI funds, persistent optimism in planning and starting projects, evolution of SDI architecture, and accuracy of cost estimates.

  9. Focusing educational initiatives

    NASA Technical Reports Server (NTRS)

    Parks, George K.

    1990-01-01

    The United States will soon be facing a critical shortage of aerospace scientists and engineers. To address this problem, Space Grant Colleges can assist in focusing interest in existing educational initiatives and in creating new educational opportunities, particularly for women and underrepresented minorities.

  10. America's Caribbean Basin Initiative.

    ERIC Educational Resources Information Center

    Kasten, Robert W.

    1983-01-01

    Nearly all of the countries that have succeeded in their development over the past 30 years have done so on the strength of market-oriented policies and vigorous participation in the international economy. Aid must be complemented by trade and investment. The Caribbean Basin Initiative puts these principles into practice. (RM)

  11. Initial Teaching Orthographies.

    ERIC Educational Resources Information Center

    Dewey, Godfrey

    To achieve its purpose, an initial teaching orthography (i.t.o.) should be as simple in form and substance as possible; it should be phonemic rather than phonetic. The 40 sounds distinguished by Pitmanic shorthand and some provision for schwa can serve as a basic code. The symbols can be derived from either of two major sources--standardizing the…

  12. Identification of delphinidin 3-O-(6''-O-malonyl)-beta-glucoside-3'-O-beta-glucoside, a postulated intermediate in the biosynthesis of ternatin C5 in the blue petals of Clitoria ternatea (butterfly pea).

    PubMed

    Kazuma, Kohei; Kogawa, Koichiro; Noda, Naonobu; Kato, Naoki; Suzuki, Masahiko

    2004-11-01

    Ternatins are blue anthocyanins found in the petals of Clitoria ternata (butterfly pea). Among them, ternatin C5 (delphinidin 3-O-(6''-O-malonyl)-beta-glucoside-3',5'-di-O-beta-glucoside; 2) has the structure common to all the ternatins, which is characterized by its glucosylation pattern: a 3,3',5'-triglucosylated anthocyanidin. In the course of studying biosynthetic pathways of ternatins, the key enzymatic activities to produce ternatin C5 were discovered in a crude enzyme preparation from the petals of a blue petal line of C. ternatea. When this preparation was tested for activity against several delphinidin glycosides, delphinidin 3-O-(6''-O-malonyl)-beta-glucoside-3'-O-beta-glucoside (6), a postulated intermediate, was found in the reaction mixture, together with three known anthocyanins, which were spectroscopically structurally identified. As a result of structural identification, the following enzymatic activities were identified: UDP-glucose :delphinidin 3-O-(6''-O-malonyl)-beta-glucoside-3'-O-beta-glucoside 5'-O-glucosyltransferase (5'GT), UDP-glucose :delphinidin 3-O-(6''-O-malonyl)-beta-glucoside 3'-O-glucosyltransferase (3'GT), UDP-glucose :delphinidin 3-O-glucosyltransferase, and malonyl-CoA :delphinidin 3-O-beta-glucoside 6''-malonyltransferase. In a mauve petal line, which did not accumulate ternatins but delphinidin 3-O-(6''-O-malonyl)-beta-glucoside in its petal, there were neither 5'GT nor 3'GT activities. Thus, the early biosynthetic pathway of ternatins may be characterized by the stepwise transfer of two glucose residues to 3'- and 5'-position of delphinidin 3-O-(6''-O-malonyl)-beta-glucoside (1; Scheme) from UDP-glucose.

  13. Event valence and unrealistic optimism.

    PubMed

    Gold, Ron S; Martyn, Kate

    2003-06-01

    The effect of event valence on unrealistic optimism was studied. 94 Deakin University students rated the comparative likelihood that they would experience either a controllable or an uncontrollable health-related event. Valence was manipulated to be positive (outcome was desirable) or negative (outcome was undesirable) by varying the way a given event was framed. Participants either were told the conditions which promote the event and rated the comparative likelihood they would experience it or were told the conditions which prevent the event and rated the comparative likelihood they would avoid it. For both the controllable and the uncontrollable events, unrealistic optimism was greater for negative than positive valence. It is suggested that a combination of the 'motivational account' of unrealistic optimism and prospect theory provides a good explanation of the results.

  14. Extreme events in computational turbulence

    PubMed Central

    Yeung, P. K.; Zhai, X. M.; Sreenivasan, Katepalli R.

    2015-01-01

    We have performed direct numerical simulations of homogeneous and isotropic turbulence in a periodic box with 8,1923 grid points. These are the largest simulations performed, to date, aimed at improving our understanding of turbulence small-scale structure. We present some basic statistical results and focus on “extreme” events (whose magnitudes are several tens of thousands the mean value). The structure of these extreme events is quite different from that of moderately large events (of the order of 10 times the mean value). In particular, intense vorticity occurs primarily in the form of tubes for moderately large events whereas it is much more “chunky” for extreme events (though probably overlaid on the traditional vortex tubes). We track the temporal evolution of extreme events and find that they are generally short-lived. Extreme magnitudes of energy dissipation rate and enstrophy occur simultaneously in space and remain nearly colocated during their evolution. PMID:26424452

  15. Calcium ion currents mediating oocyte maturation events

    PubMed Central

    Tosti, Elisabetta

    2006-01-01

    During maturation, the last phase of oogenesis, the oocyte undergoes several changes which prepare it to be ovulated and fertilized. Immature oocytes are arrested in the first meiotic process prophase, that is morphologically identified by a germinal vesicle. The removal of the first meiotic block marks the initiation of maturation. Although a large number of molecules are involved in complex sequences of events, there is evidence that a calcium increase plays a pivotal role in meiosis re-initiation. It is well established that, during this process, calcium is released from the intracellular stores, whereas less is known on the role of external calcium entering the cell through the plasma membrane ion channels. This review is focused on the functional role of calcium currents during oocyte maturation in all the species, from invertebrates to mammals. The emerging role of specific L-type calcium channels will be discussed. PMID:16684344

  16. Human performance analysis of industrial radiography radiation exposure events

    SciTech Connect

    Reece, W.J.; Hill, S.G.

    1995-12-01

    A set of radiation overexposure event reports were reviewed as part of a program to examine human performance in industrial radiography for the US Nuclear Regulatory Commission. Incident records for a seven year period were retrieved from an event database. Ninety-five exposure events were initially categorized and sorted for further analysis. Descriptive models were applied to a subset of severe overexposure events. Modeling included: (1) operational sequence tables to outline the key human actions and interactions with equipment, (2) human reliability event trees, (3) an application of an information processing failures model, and (4) an extrapolated use of the error influences and effects diagram. Results of the modeling analyses provided insights into the industrial radiography task and suggested areas for further action and study to decrease overexposures.

  17. Event-centric media management

    NASA Astrophysics Data System (ADS)

    Scherp, Ansgar; Agaram, Srikanth; Jain, Ramesh

    2008-01-01

    The management of the vast amount of media assets captured at every day events such as meetings, birthday parties, vacation, and conferences has become an increasingly challenging problem. Today, most media management applications are media-centric. This means, they put the captured media assets into the center of the management. However, in recent years it has been proposed that events are a much better abstraction of human experience and thus provide a more appropriate means for managing media assets. Consequently, approaches that include events into their media management solution have been explored. However, they typically consider events only as some more metadata that can be extracted from the media assets. In addition, today's applications and approaches concentrate on particular problems such as event detection, tagging, sharing, classification, or clustering and are often focused on a single media type. In this paper, we argue for the benefits of an event-centric media management (EMMa) approach that looks at the problem of media management holistically. Based on a generic event model, we specify a media event model for the EMMa approach. The single phases and processes of the EMMa approach are defined in a general process chain for an event-centric media management, the EMMa cycle. This cycle follows the event concept throughout all phases and processes of the chain and puts the concept of events in the center of the media management. Based on the media event model and EMMa cycle, we design a component-based architecture for the EMMa approach and conduct an implementation of the approach.

  18. External events analysis for the Savannah River Site K reactor

    SciTech Connect

    Brandyberry, M.D.; Wingo, H.E.

    1990-01-01

    The probabilistic external events analysis performed for the Savannah River Site K-reactor PRA considered many different events which are generally perceived to be external'' to the reactor and its systems, such as fires, floods, seismic events, and transportation accidents (as well as many others). Events which have been shown to be significant contributors to risk include seismic events, tornados, a crane failure scenario, fires and dam failures. The total contribution to the core melt frequency from external initiators has been found to be 2.2 {times} 10{sup {minus}4} per year, from which seismic events are the major contributor (1.2 {times} 10{sup {minus}4} per year). Fire initiated events contribute 1.4 {times} 10{sup {minus}7} per year, tornados 5.8 {times} 10{sup {minus}7} per year, dam failures 1.5 {times} 10{sup {minus}6} per year and the crane failure scenario less than 10{sup {minus}4} per year to the core melt frequency. 8 refs., 3 figs., 5 tabs.

  19. Event oriented dictionary learning for complex event detection.

    PubMed

    Yan, Yan; Yang, Yi; Meng, Deyu; Liu, Gaowen; Tong, Wei; Hauptmann, Alexander G; Sebe, Nicu

    2015-06-01

    Complex event detection is a retrieval task with the goal of finding videos of a particular event in a large-scale unconstrained Internet video archive, given example videos and text descriptions. Nowadays, different multimodal fusion schemes of low-level and high-level features are extensively investigated and evaluated for the complex event detection task. However, how to effectively select the high-level semantic meaningful concepts from a large pool to assist complex event detection is rarely studied in the literature. In this paper, we propose a novel strategy to automatically select semantic meaningful concepts for the event detection task based on both the events-kit text descriptions and the concepts high-level feature descriptions. Moreover, we introduce a novel event oriented dictionary representation based on the selected semantic concepts. Toward this goal, we leverage training images (frames) of selected concepts from the semantic indexing dataset with a pool of 346 concepts, into a novel supervised multitask lp -norm dictionary learning framework. Extensive experimental results on TRECVID multimedia event detection dataset demonstrate the efficacy of our proposed method.

  20. Gravity wave initiated convection

    NASA Technical Reports Server (NTRS)

    Hung, R. J.

    1990-01-01

    The vertical velocity of convection initiated by gravity waves was investigated. In one particular case, the convective motion-initiated and supported by the gravity wave-induced activity (excluding contributions made by other mechanisms) reached its maximum value about one hour before the production of the funnel clouds. In another case, both rawinsonde and geosynchronous satellite imagery were used to study the life cycles of severe convective storms. Cloud modelling with input sounding data and rapid-scan imagery from GOES were used to investigate storm cloud formation, development and dissipation in terms of growth and collapse of cloud tops, as well as, the life cycles of the penetration of overshooting turrets above the tropopause. The results based on these two approaches are presented and discussed.

  1. The NLM Indexing Initiative.

    PubMed

    Aronson, A R; Bodenreider, O; Chang, H F; Humphrey, S M; Mork, J G; Nelson, S J; Rindflesch, T C; Wilbur, W J

    2000-01-01

    The objective of NLM's Indexing Initiative (IND) is to investigate methods whereby automated indexing methods partially or completely substitute for current indexing practices. The project will be considered a success if methods can be designed and implemented that result in retrieval performance that is equal to or better than the retrieval performance of systems based principally on humanly assigned index terms. We describe the current state of the project and discuss our plans for the future.

  2. Laser Initiated Actuator study

    SciTech Connect

    Watson, B.

    1991-06-27

    The program task was to design and study a laser initiated actuator. The design of the actuator is described, it being comprised of the fiber and body subassemblies. The energy source for all experiments was a Spectra Diode 2200-H2 laser diode. The diode is directly coupled to a 100 micron core, 0.3 numerical aperture fiber optic terminated with an SMA connector. The successful testing results are described and recommendations are made.

  3. Genetics of Fiber Initiation

    Technology Transfer Automated Retrieval System (TEKTRAN)

    To study the cellular mechanisms involved in fiber initiation, three fiberless lines were crossed with wildtype and fuzzless seed cotton and the F1, F2 and BC1 progeny ratios are presently being evaluated. The three fiberless lines included: MD17 (N1N1n2n2), SL1-7-1 (N1N1fl1fl1n3n3) and XZ142w. XZ...

  4. The space exploration initiative

    NASA Technical Reports Server (NTRS)

    Priest, Pete

    1991-01-01

    A number of view graph charts are presented which outline the presentation. Outlined are reasons for going to Mars, why it is necessary to go to the Moon first, and the presidential decision on the space exploration initiative. Other representative charts are entitled: Lunar transportation system requirement drivers; Mars transportation system requirement drivers; National space policy goals; Exploration hardware needed; Mars mission profile; Science on the Moon and Mars; and Two independent reviews.

  5. The OpenPlanetary initiative

    NASA Astrophysics Data System (ADS)

    Manaud, Nicolas; Rossi, Angelo Pio; Hare, Trent; Aye, Michael; Galluzzi, Valentina; van Gasselt, Stephan; Martinez, Santa; McAuliffe, Jonathan; Million, Chase; Nass, Andrea; Zinzi, Angelo

    2016-10-01

    "Open" has become attached to several concepts: science, data, and software are some of the most obvious. It is already common practice within the planetary science community to share spacecraft missions data freely and openly [1]. However, this is not historically the case for software tools, source code, and derived data sets, which are often reproduced independently by multiple individuals and groups. Sharing data, tools and overall knowledge would increase scientific return and benefits [e.g. 2], and recent projects and initiatives are helping toward this goal [e.g. 3,4,5,6].OpenPlanetary is a bottom-up initiative to address the need of the planetary science community for sharing ideas and collaborating on common planetary research and data analysis problems, new challenges, and opportunities. It started from an initial participants effort to stay connected and share information related to and beyond the ESA's first Planetary GIS Workshop [7]. It then continued during the 2nd (US) Planetary Data Workshop [8], and aggregated more people.Our objective is to build an online distributed framework enabling open collaborations within the planetary science community. We aim to co-create, curate and publish resource materials and data sets; to organise online events, to support community-based projects development; and to offer a real-time communication channel at and between conferences and workshops.We will present our current framework and resources, developing projects and ideas, and solicit for feedback and participation. OpenPlanetary is intended for research and education professionals: scientists, engineers, designers, teachers and students, as well as the general public that includes enthusiasts and citizen scientists. All are welcome to join and contribute at openplanetary.co[1] International Planetary Data Alliance, planetarydata.org. [2] Nosek et al (2015), dx.doi.org/10.1126/science.aab2374. [3] Erard S. et al. (2016), EGU2016-17527. [4] Proposal for a PDS

  6. The ISC Seismic Event Bibliography

    NASA Astrophysics Data System (ADS)

    Di Giacomo, Domenico; Storchak, Dmitry

    2015-04-01

    The International Seismological Centre (ISC) is a not-for-profit organization operating in the UK for the last 50 years and producing the ISC Bulletin - the definitive worldwide summary of seismic events, both natural and anthropogenic - starting from the beginning of 20th century. Often researchers need to gather information related to specific seismic events for various reasons. To facilitate such task, in 2012 we set up a new database linking earthquakes and other seismic events in the ISC Bulletin to bibliographic records of scientific articles (mostly peer-reviewed journals) that describe those events. Such association allows users of the ISC Event Bibliography (www.isc.ac.uk/event_bibliography/index.php) to run searches for publications via a map-based web interface and, optionally, selecting scientific publications related to either specific events or events in the area of interest. Some of the greatest earthquakes were described in several hundreds of articles published over a period of few years. The journals included in our database are not limited to seismology but bring together a variety of fields in geosciences (e.g., engineering seismology, geodesy and remote sensing, tectonophysics, monitoring research, tsunami, geology, geochemistry, hydrogeology, atmospheric sciences, etc.) making this service useful in multidisciplinary studies. Usually papers dealing with large data set are not included (e.g., papers describing a seismic catalogue). Currently the ISC Event Bibliography includes over 17,000 individual publications from about 500 titles related to over 14,000 events that occurred in last 100+ years. The bibliographic records in the Event Bibliography start in the 1950s, and it is updated as new publications become available.

  7. MSI develops refugee initiative.

    PubMed

    1996-01-01

    This brief article highlights the new initiative by Marie Stopes International (MSI), which is part of a Reproductive Health for Refugees Consortium of four organizations formed in 1995. The new initiative will promote awareness about the need for reproductive health among refugees. Over 80% of refugees are women and children who fled a variety of disasters only to be at high risk from sexual violence, sexually transmitted infections, and the effects of unintended and unsafe pregnancies. The consortium members will work to increase donors' understanding of the health conditions of women and to significantly increase donor support for reproductive health initiatives. In addition to the role of advocacy, MSI will be introducing refugee services into its global network of reproductive health services. MSI gained experience in delivering reproductive health services in refugee situations in the former Yugoslavia and among Mozambican refugees in Malawi. MSI is investigating sources of information from several countries about refugees' needs. The consortium is also collecting information on the most effective ways of delivering reproductive health services in refugee situations. The aim is to institutionalize reproductive health services into all humanitarian responses. MSI has developed refugee programs over the past 3 years in the former Yugoslavia, Malawi, Sri Lanka, and Sierra Leone. MSI expects to establish projects in 1996 for refugees in Zaire, Guinea, and Mozambique. The numbers of displaced persons or refugees is continuing to increase worldwide, and there is a continued need to provide for these vulnerable communities.

  8. Initiation Train Experiments

    NASA Astrophysics Data System (ADS)

    Francois, Elizabeth; Johnson, Carl; Liechty, Gary; Whitley, Von

    2015-06-01

    In an effort to evaluate and qualify a new detonator diagnostic, booster selection and main charge configuration, a variety of small-scale tests have been conducted. This paper will describe the needs, testing approach and model validation. Because of the limited size available some novel approaches were made to understand the observed phenomenon. Function time and time of arrival at various locations in the initiation train are desirable data points. Knowing when each segment initiates the next segment and the time to run up to detonation is critical. Results of our experiments were modeled for timing accuracy, wave shape and pressure. Agreement between the experiments and models will be discussed. The testing that will be discussed is time of arrival wires, PDV, and fiber optic arrays. The time of arrival wire measures the detonator cup breakout time. When correlated to bridge burst, an absolute time is collected. This data point also gives time zero for the booster initiation. Many models actually start at the booster, rather than the detonator, so the inclusion of this data point will improve modeling efforts.

  9. Drivers of flood damage on event level

    NASA Astrophysics Data System (ADS)

    Kreibich, Heidi

    2016-04-01

    Flood risk is dynamic and influenced by many processes related to hazard, exposure and vulnerability. Flood damage increased significantly over the past decades, however, resulting overall economic loss per event is an aggregated indicator and it is difficult to attribute causes to this increasing trend. Much has been learned about damaging processes during floods at the micro-scale, e.g. building level. However, little is known about the main factors determining the amount of flood damage on event level. Thus, we analyse and compare paired flood events, i.e. consecutive, similar damaging floods that occurred in the same area. In analogy to 'Paired catchment studies' - a well-established method in hydrology to understand how changes in land use affect streamflow - we will investigate how and why resulting flood damage in a region differed between the first and second consecutive flood events. One example are the 2002 and 2013 floods in the Elbe and Danube catchments in Germany. The 2002 flood caused the highest economic damage (EUR 11600 million) due to a natural hazard event in Germany. Damage was so high due to extreme flood hazard triggered by extreme precipitation and a high number of resulting dyke breaches. Additionally, exposure hotspots like the city of Dresden at the Elbe river as well as some smaller municipalities at the river Mulde (e.g. Grimma, Eilenburg, Bitterfeld, Dessau) were severely impacted. However, affected parties and authorities learned from the extreme flood in 2002, and many governmental flood risk programs and initiatives were launched. Considerable improvements since 2002 occurred on many levels that deal with flood risk reduction and disaster response, in particular in 1) increased flood prevention by improved spatial planning, 2) an increased number of property-level mitigation measures, 3) more effective early warning and improved coordination of disaster response and 4) a more targeted maintenance of flood defence systems and their

  10. Virginia DECA Competitive Events Handbook.

    ERIC Educational Resources Information Center

    Henrico County Public Schools, Glen Allen, VA. Virginia Vocational Curriculum Center.

    This handbook combines in a single publication several sets of guidelines for separate competitive events sponsored by the Virginia Association of the Distributive Education Clubs of America (VA DECA). The handbook is organized to promote understanding of the relationships between the competitive events held on the national level and those…

  11. Regularly timed events amid chaos

    NASA Astrophysics Data System (ADS)

    Blakely, Jonathan N.; Cooper, Roy M.; Corron, Ned J.

    2015-11-01

    We show rigorously that the solutions of a class of chaotic oscillators are characterized by regularly timed events in which the derivative of the solution is instantaneously zero. The perfect regularity of these events is in stark contrast with the well-known unpredictability of chaos. We explore some consequences of these regularly timed events through experiments using chaotic electronic circuits. First, we show that a feedback loop can be implemented to phase lock the regularly timed events to a periodic external signal. In this arrangement the external signal regulates the timing of the chaotic signal but does not strictly lock its phase. That is, phase slips of the chaotic oscillation persist without disturbing timing of the regular events. Second, we couple the regularly timed events of one chaotic oscillator to those of another. A state of synchronization is observed where the oscillators exhibit synchronized regular events while their chaotic amplitudes and phases evolve independently. Finally, we add additional coupling to synchronize the amplitudes, as well, however in the opposite direction illustrating the independence of the amplitudes from the regularly timed events.

  12. Subjective Evaluation of Life Events.

    ERIC Educational Resources Information Center

    Fontana, Alan F.; And Others

    1979-01-01

    Surveyed medical/surgical patients concerning life events during the preceding year. Subjective evaluations of events were obtained for dimensions of desirability, adjustment, anticipation, and control. Psychological impairment was associated with subjective evaluations, specifically desirability and adjustment. Inclusion of anticipation and…

  13. Media Relations: The Planned Event.

    ERIC Educational Resources Information Center

    Larson, Mark A.

    Intended for use by instructors of public relations courses, this paper discusses teaching methods that can be used to demonstrate to students how much of the news involves events that are carefully planned by public relations practitioners and some of the techniques the practitioners use to create these events. The paper describes in detail…

  14. Eventos de Junio (June Events).

    ERIC Educational Resources Information Center

    Pla, Myrna; Toro, Leonor

    Written in Spanish, this booklet contains brief information on six June events celebrated by Puerto Ricans: Nathan Hale, Dia de la Bandera (Flag Day), Francisco Oller, Dia de los Padres (Father's Day), Fiesta de San Juan Bautista, and school graduation. Designed for teachers, the booklet includes a listing of 16 historical events occurring in…

  15. CHED Events: Salt Lake City

    NASA Astrophysics Data System (ADS)

    Wink, Donald J.

    2009-03-01

    The Division of Chemical Education (CHED) Committee meetings planned for the Spring 2009 ACS Meeting in Salt Lake City will be in the Marriott City Center Hotel. Check the location of other CHED events, the CHED Social Event, the Undergraduate Program, Sci-Mix, etc. because many will be in the Salt Palace Convention Center.

  16. The Reinforcing Event (RE) Menu

    ERIC Educational Resources Information Center

    Addison, Roger M.; Homme, Lloyd E.

    1973-01-01

    A motivational system, the Contingency Management System, uses contracts in which some amount of defined task behavior is demanded for some interval of reinforcing event. The Reinforcing Event Menu, a list of high probability reinforcing behaviors, is used in the system as a prompting device for the learner and as an aid for the administrator in…

  17. Complex events in a fault model with interacting asperities

    NASA Astrophysics Data System (ADS)

    Dragoni, Michele; Tallarico, Andrea

    2016-08-01

    The dynamics of a fault with heterogeneous friction is studied by employing a discrete fault model with two asperities of different strengths. The average values of stress, friction and slip on each asperity are considered and the state of the fault is described by the slip deficits of the asperities as functions of time. The fault has three different slipping modes, corresponding to the asperities slipping one at a time or simultaneously. Any seismic event produced by the fault is a sequence of n slipping modes. According to initial conditions, seismic events can be different sequences of slipping modes, implying different moment rates and seismic moments. Each event can be represented geometrically in the state space by an orbit that is the union of n damped Lissajous curves. We focus our interest on events that are sequences of two or more slipping modes: they show a complex stress interchange between the asperities and a complex temporal pattern of slip rate. The initial stress distribution producing these events is not uniform on the fault. We calculate the stress drop, the moment rate and the frequency spectrum of the events, showing how these quantities depend on initial conditions. These events have the greatest seismic moments that can be produced by fault slip. As an example, we model the moment rate of the 1992 Landers, California, earthquake that can be described as the consecutive failure of two asperities, one of which has a double strength than the other, and evaluate the evolution of stress distribution on the fault during the event.

  18. Event group importance measures for top event frequency analyses

    SciTech Connect

    1995-07-31

    Three traditional importance measures, risk reduction, partial derivative, nd variance reduction, have been extended to permit analyses of the relative importance of groups of underlying failure rates to the frequencies of resulting top events. The partial derivative importance measure was extended by assessing the contribution of a group of events to the gradient of the top event frequency. Given the moments of the distributions that characterize the uncertainties in the underlying failure rates, the expectation values of the top event frequency, its variance, and all of the new group importance measures can be quantified exactly for two familiar cases: (1) when all underlying failure rates are presumed independent, and (2) when pairs of failure rates based on common data are treated as being equal (totally correlated). In these cases, the new importance measures, which can also be applied to assess the importance of individual events, obviate the need for Monte Carlo sampling. The event group importance measures are illustrated using a small example problem and demonstrated by applications made as part of a major reactor facility risk assessment. These illustrations and applications indicate both the utility and the versatility of the event group importance measures.

  19. ISEE 3 observations of low-energy proton bidirectional events and their relation to isolated interplanetary magnetic structures

    NASA Technical Reports Server (NTRS)

    Marsden, R. G.; Sanderson, T. R.; Tranquille, C.; Wenzel, K.-P.; Smith, E. J.

    1987-01-01

    The paper represents the results of a comprehensive survey of low-energy proton bidirectional anisotropies and associated transient magnetic structures as observed in the 35-1600 keV energy range on ISEE-3 during the last solar maximum. The majority of observed bidirectional flow (BDF) events (more than 70 percent) are associated with isolated magnetic structures which are postulated to be an interplanetary manifestation of coronal mass ejection (CME) events. The observed BDF events can be qualitatively grouped into five classes depending on the field signature of the related magnetic structure and the association (or lack of association) with an interplanetary shock. Concerning the topology of the CME-related magnetic structures, the observations are interpreted as being consistent with a detached bubble, comprising closed loops or tightly wound helices.

  20. Mid-Carboniferous eustatic event

    SciTech Connect

    Saunders, W.B.; Ramsbottom, W.H.C.

    1986-03-01

    Stratigraphic and paleontologic evidence from mid-Carboniferous (Namurian) basin and shelf successions in widely scattered parts of the world indicates that a major eustatic event occurred about 330 Ma. The event began with a regression that is recorded in most shelf sequences, the regression was followed by a brief transgression about 328 Ma, and the event ended with a transgression that flooded large shelf areas about 325 Ma. The Mississippian-Pennsylvanian unconformity in North America is a well-known product of this event, but equally prominent and contemporaneous unconformity surfaces are also present in Europe, North Africa, and elsewhere. The event is believed to have caused numerous extinctions, and it resulted in marked fluctuations in faunal diversity. 94 references, 2 figures.

  1. Precision Jet Substructure from Boosted Event Shapes

    NASA Astrophysics Data System (ADS)

    Feige, Ilya; Schwartz, Matthew D.; Stewart, Iain W.; Thaler, Jesse

    2012-08-01

    Jet substructure has emerged as a critical tool for LHC searches, but studies so far have relied heavily on shower Monte Carlo simulations, which formally approximate QCD at the leading-log level. We demonstrate that systematic higher-order QCD computations of jet substructure can be carried out by boosting global event shapes by a large momentum Q and accounting for effects due to finite jet size, initial-state radiation (ISR), and the underlying event (UE) as 1/Q corrections. In particular, we compute the 2-subjettiness substructure distribution for boosted Z→qq¯ events at the LHC at next-to-next-to-next-to-leading-log order. The calculation is greatly simplified by recycling known results for the thrust distribution in e+e- collisions. The 2-subjettiness distribution quickly saturates, becoming Q independent for Q≳400GeV. Crucially, the effects of jet contamination from ISR/UE can be subtracted out analytically at large Q without knowing their detailed form. Amusingly, the Q=∞ and Q=0 distributions are related by a scaling by e up to next-to-leading-log order.

  2. Constructing Dynamic Event Trees from Markov Models

    SciTech Connect

    Paolo Bucci; Jason Kirschenbaum; Tunc Aldemir; Curtis Smith; Ted Wood

    2006-05-01

    In the probabilistic risk assessment (PRA) of process plants, Markov models can be used to model accurately the complex dynamic interactions between plant physical process variables (e.g., temperature, pressure, etc.) and the instrumentation and control system that monitors and manages the process. One limitation of this approach that has prevented its use in nuclear power plant PRAs is the difficulty of integrating the results of a Markov analysis into an existing PRA. In this paper, we explore a new approach to the generation of failure scenarios and their compilation into dynamic event trees from a Markov model of the system. These event trees can be integrated into an existing PRA using software tools such as SAPHIRE. To implement our approach, we first construct a discrete-time Markov chain modeling the system of interest by: a) partitioning the process variable state space into magnitude intervals (cells), b) using analytical equations or a system simulator to determine the transition probabilities between the cells through the cell-to-cell mapping technique, and, c) using given failure/repair data for all the components of interest. The Markov transition matrix thus generated can be thought of as a process model describing the stochastic dynamic behavior of the finite-state system. We can therefore search the state space starting from a set of initial states to explore all possible paths to failure (scenarios) with associated probabilities. We can also construct event trees of arbitrary depth by tracing paths from a chosen initiating event and recording the following events while keeping track of the probabilities associated with each branch in the tree. As an example of our approach, we use the simple level control system often used as benchmark in the literature with one process variable (liquid level in a tank), and three control units: a drain unit and two supply units. Each unit includes a separate level sensor to observe the liquid level in the tank

  3. Monitoring DNA recombination initiated by HO endonuclease.

    PubMed

    Sugawara, Neal; Haber, James E

    2012-01-01

    DNA double-strand breaks (DSBs) have proven to be very potent initiators of recombination in yeast and other organisms. A single, site-specific DSB initiates homologous DNA repair events such as gene conversion, break-induced replication, and single-strand annealing, as well as nonhomologous end joining, microhomology-mediated end joining, and new telomere addition. When repair is either delayed or prevented, a single DSB can trigger checkpoint-mediated cell cycle arrest. In budding yeast, expressing the HO endonuclease under the control of a galactose-inducible promoter has been instrumental in the study of these processes by providing us a way to synchronously induce a DSB at a unique site in vivo. We describe how the HO endonuclease has been used to study the recombination events in mating-type (MAT) switching. Southern blots provide an overview of the process by allowing one to examine the formation of the DSB, DNA degradation at the break, and formation of the product. Denaturing gels and slot blots as well as PCR have provided important tools to follow the progression of resection in wild-type and mutant cells. PCR has also been important in allowing us to follow the kinetics of certain recombination intermediates such as the initiation of repair DNA synthesis or the removal of nonhomologous Y sequences during MAT switching. Finally chromatin immunoprecipitation has been used to follow the recruitment of key proteins to the DSB and in subsequent steps in DSB repair.

  4. Through bulkhead initiator studies

    SciTech Connect

    Begeal, D.R.

    1997-03-01

    This report describes recent work done to demonstrate feasibility of a fail-safe Through Bulkhead Initiator with minimum dimensions and suitable for use in cyclical thermal environments. Much of the ground work for a fail-safe TBI was previously done by A.C. Schwartz. This study is an expansion of Schwartz`s work to evaluate devices with bulkheads of 304 stainless steel and Inconel 718; explosive donors of PETN, BNCP, and a 0.005 inch thick steel flying plate donor traveling at 2.6 mm/{micro}s; and explosive acceptors of PETN and BNCP. Bulkhead thickness were evaluated in the range of 0.040 to 0.180 inch. The explosive acceptors initiated a small HMX pellet to drive a 0.005 inch thick steel flying plate, and VISAR histories of the HMX-driven flying plates were the measure of acceptable performance. A companion set of samples used a PMMA acceptor to measure the particle velocities at the bulkhead/PMMA interface with VISAR. These data were used to compute the input pressure to the acceptor explosives in an attempt to measure initiation threshold. Unfortunately, the range of bulkhead thicknesses tested did not give any failures, thus the threshold was not determined. It was found that either explosive or the flying plate would perform as a TBI in the bulkhead thickness range tested. The optimum TBI is about 0.060 inches thick, and steel bulkheads seem to be more structurally sound than those made of Inconel. That is, cross section views of the Inconel bulkheads showed it to be more prone to stress cracking than was the 304 stainless steel. Both PETN and BNCP showed good performance when tested at {minus}65 F following thermal cycling of {minus}65 F to +165 F. Analysis of the TBI function times showed that BNCP acceptor explosives were undergoing the classical deflagration to detonation process. The PETN acceptors were undergoing prompt detonation.

  5. Initial blood storage experiment

    NASA Technical Reports Server (NTRS)

    Surgenor, Douglas MACN.

    1988-01-01

    The design of the Initial Blood Storage Experiment (IBSE) was based upon a carefully controlled comparison between identical sets of human blood cell suspensions - red cells, white cell, and platelets - one set of which was transported aboard the Columbia on a 6 day 11 hour mission, and the other held on the ground. Both sets were carried inside stainless steel dewars within specially fabricated flight hardware. Individual bags of cell suspensions were randomly assigned with respect to ground vs orbit status, dewar chamber, and specific location within the dewar. To foster optimal preservation, each cell type was held under specific optimal conditions of pH, ionic strength, solute concentration, gas tension, and temperature. An added variable in this initial experiment was provided by the use of three different polymer/plasticizer formulations for the sealed bags which held the blood cells. At termination of the experiment, aliquots of the suspensions, identified only by code, were distributed to be assayed. Assays were selected to constitute a broad survey of cellular properties and thereby maximize the chances of detection of gravitational effects. A total of 74 different outcome measurements were reported for statistical analysis. When the measurements were completed, the results were entered into the IBSE data base, at which time the data were matched with the original blood bag numbers to determine their status with respect to polymer/plasticizer type, orbit status (orbit or ground), and storage position within the experimental hardware. The data were studied by analysis of variance. Initially, type of bag and orbital status were main factors; later more detailed analyses were made on specific issues such as position in the hardware and specific plastic. If the analysis of variance indicated a statistical significance at the 5 percent level the corresponding p-value was reported.

  6. Stirling to Flight Initiative

    NASA Technical Reports Server (NTRS)

    Hibbard, Kenneth E.; Mason, Lee S.; Ndu, Obi; Smith, Clayton; Withrow, James P.

    2016-01-01

    Flight (S2F) initiative with the objective of developing a 100-500 We Stirling generator system. Additionally, a different approach is being devised for this initiative to avoid pitfalls of the past, and apply lessons learned from the recent ASRG experience. Two key aspects of this initiative are a Stirling System Technology Maturation Effort, and a Surrogate Mission Team (SMT) intended to provide clear mission pull and requirements context. The S2F project seeks to lead directly into a DOE flight system development of a new SRG. This paper will detail the proposed S2F initiative, and provide specifics on the key efforts designed to pave a forward path for bringing Stirling technology to flight.

  7. UNLV Nuclear Hydrogen Initiative

    SciTech Connect

    Hechanova, Anthony E.; Johnson, Allen; O'Toole, Brendan; Trabia, Mohamed; Peterson, Per

    2012-10-25

    Evaluation of the Crack growth rate (CGR) of Alloy 617 and Alloy 276 under constant K at ambient temperature has been completed. Creep deformation of Alloy 230 at different temperature range and load level has been completed and heat to heat variation has been noticed. Creep deformation study of Alloy 276 has been completed under an applied initial stress level of 10% of yield stress at 950ºC. The grain size evaluation of the tested creep specimens of Alloy 276 has been completed.

  8. Space Exploration Initiative

    NASA Technical Reports Server (NTRS)

    1990-01-01

    An overview of President Bush's Space Exploration Initiative (SEI) and it's three main components, Space Station Freedom, a Permanent Lunar Base, and a Manned Mission to Mars is provided. Computer simulations of the Space Station Freedom and Permanent Lunar Base are shown, and an animated sequence describes a Mars mission where heavy lift vehicle will bring components of a Mars Spacecraft into orbit, where it will be put together by astronauts using a robotic arm. The Mars spacecraft is shown orbiting Mars and discharging a lander to the surface, carrying human explorers. The video also details the SEI's Outreach Program, designed to garner interest in and ideas for Space Exploration.

  9. Initiation of slug flow

    SciTech Connect

    Hanratty, T.J.; Woods, B.D.

    1995-12-31

    The initiation of slug flow in a horizontal pipe can be predicted either by considering the stability of a slug or by considering the stability of a stratified flow. Measurements of the shedding rate of slugs are used to define necessary conditions for the existence of a slug. Recent results show that slugs develop from an unstable stratified flow through the evolution of small wavelength waves into large wavelength waves that have the possibility of growing to form a slug. The mechanism appears to be quite different for fluids with viscosities close to water than for fluids with large viscosities (20 centipoise).

  10. Human Research Initiative (HRI)

    NASA Technical Reports Server (NTRS)

    Motil, Brian

    2003-01-01

    A code U initiative starting in the FY04 budget includes specific funding for 'Phase Change' and 'Multiphase Flow Research' on the ISS. NASA GRC developed a concept for two facilities based on funding/schedule constraints: 1) Two Phase Flow Facility (TphiFFy) which assumes integrating into FIR; 2) Contact Line Dynamics Experiment Facility (CLiDE) which assumes integration into MSG. Each facility will accommodate multiple experiments conducted by NRA selected PIs with an overall goal of enabling specific NASA strategic objectives. There may also be a significant ground-based component.

  11. Hanford tanks initiative plan

    SciTech Connect

    McKinney, K.E.

    1997-07-01

    Abstract: The Hanford Tanks Initiative (HTI) is a five-year project resulting from the technical and financial partnership of the U.S. Department of Energy`s Office of Waste Management (EM-30) and Office of Science and Technology Development (EM-50). The HTI project accelerates activities to gain key technical, cost performance, and regulatory information on two high-level waste tanks. The HTI will provide a basis for design and regulatory decisions affecting the remainder of the Tank Waste Remediation System`s tank waste retrieval Program.

  12. Feedback stabilization initiative

    SciTech Connect

    1997-06-01

    Much progress has been made in attaining high confinement regimes in magnetic confinement devices. These operating modes tend to be transient, however, due to the onset of MHD instabilities, and their stabilization is critical for improved performance at steady state. This report describes the Feedback Stabilization Initiative (FSI), a broad-based, multi-institutional effort to develop and implement methods for raising the achievable plasma betas through active MHD feedback stabilization. A key element in this proposed effort is the Feedback Stabilization Experiment (FSX), a medium-sized, national facility that would be specifically dedicated to demonstrating beta improvement in reactor relevant plasmas by using a variety of MHD feedback stabilization schemes.

  13. Advanced Monitoring systems initiative

    SciTech Connect

    R.J. Venedam; E.O. Hohman; C.F. Lohrstorfer; S.J. Weeks; J.B. Jones; W.J. Haas

    2004-09-30

    The Advanced Monitoring Systems Initiative (AMSI) actively searches for promising technologies and aggressively moves them from the research bench into DOE/NNSA end-user applications. There is a large unfulfilled need for an active element that reaches out to identify and recruit emerging sensor technologies into the test and evaluation function. Sensor research is ubiquitous, with the seeds of many novel concepts originating in the university systems, but at present these novel concepts do not move quickly and efficiently into real test environments. AMSI is a widely recognized, self-sustaining ''business'' accelerating the selection, development, testing, evaluation, and deployment of advanced monitoring systems and components.

  14. Cross sections for the reactions e+e-→KS0KL0, KS0KL0π+π-, KS0KS0π+π-, and KS0KS0K+K- from events with initial-state radiation

    NASA Astrophysics Data System (ADS)

    Lees, J. P.; Poireau, V.; Tisserand, V.; Grauges, E.; Palano, A.; Eigen, G.; Stugu, B.; Brown, D. N.; Kerth, L. T.; Kolomensky, Yu. G.; Lee, M. J.; Lynch, G.; Koch, H.; Schroeder, T.; Hearty, C.; Mattison, T. S.; McKenna, J. A.; So, R. Y.; Khan, A.; Blinov, V. E.; Buzykaev, A. R.; Druzhinin, V. P.; Golubev, V. B.; Kravchenko, E. A.; Onuchin, A. P.; Serednyakov, S. I.; Skovpen, Yu. I.; Solodov, E. P.; Todyshev, K. Yu.; Lankford, A. J.; Mandelkern, M.; Dey, B.; Gary, J. W.; Long, O.; Campagnari, C.; Franco Sevilla, M.; Hong, T. M.; Kovalskyi, D.; Richman, J. D.; West, C. A.; Eisner, A. M.; Lockman, W. S.; Panduro Vazquez, W.; Schumm, B. A.; Seiden, A.; Chao, D. S.; Cheng, C. H.; Echenard, B.; Flood, K. T.; Hitlin, D. G.; Miyashita, T. S.; Ongmongkolkul, P.; Porter, F. C.; Andreassen, R.; Huard, Z.; Meadows, B. T.; Pushpawela, B. G.; Sokoloff, M. D.; Sun, L.; Bloom, P. C.; Ford, W. T.; Gaz, A.; Smith, J. G.; Wagner, S. R.; Ayad, R.; Toki, W. H.; Spaan, B.; Bernard, D.; Verderi, M.; Playfer, S.; Bettoni, D.; Bozzi, C.; Calabrese, R.; Cibinetto, G.; Fioravanti, E.; Garzia, I.; Luppi, E.; Piemontese, L.; Santoro, V.; Calcaterra, A.; de Sangro, R.; Finocchiaro, G.; Martellotti, S.; Patteri, P.; Peruzzi, I. M.; Piccolo, M.; Rama, M.; Zallo, A.; Contri, R.; Lo Vetere, M.; Monge, M. R.; Passaggio, S.; Patrignani, C.; Robutti, E.; Bhuyan, B.; Prasad, V.; Morii, M.; Adametz, A.; Uwer, U.; Lacker, H. M.; Dauncey, P. D.; Mallik, U.; Chen, C.; Cochran, J.; Prell, S.; Ahmed, H.; Gritsan, A. V.; Arnaud, N.; Davier, M.; Derkach, D.; Grosdidier, G.; Le Diberder, F.; Lutz, A. M.; Malaescu, B.; Roudeau, P.; Stocchi, A.; Wormser, G.; Lange, D. J.; Wright, D. M.; Coleman, J. P.; Fry, J. R.; Gabathuler, E.; Hutchcroft, D. E.; Payne, D. J.; Touramanis, C.; Bevan, A. J.; Di Lodovico, F.; Sacco, R.; Cowan, G.; Bougher, J.; Brown, D. N.; Davis, C. L.; Denig, A. G.; Fritsch, M.; Gradl, W.; Griessinger, K.; Hafner, A.; Schubert, K. R.; Barlow, R. J.; Lafferty, G. D.; Cenci, R.; Hamilton, B.; Jawahery, A.; Roberts, D. A.; Cowan, R.; Sciolla, G.; Cheaib, R.; Patel, P. M.; Robertson, S. H.; Neri, N.; Palombo, F.; Cremaldi, L.; Godang, R.; Sonnek, P.; Summers, D. J.; Simard, M.; Taras, P.; De Nardo, G.; Onorato, G.; Sciacca, C.; Martinelli, M.; Raven, G.; Jessop, C. P.; LoSecco, J. M.; Honscheid, K.; Kass, R.; Feltresi, E.; Margoni, M.; Morandin, M.; Posocco, M.; Rotondo, M.; Simi, G.; Simonetto, F.; Stroili, R.; Akar, S.; Ben-Haim, E.; Bomben, M.; Bonneaud, G. R.; Briand, H.; Calderini, G.; Chauveau, J.; Leruste, Ph.; Marchiori, G.; Ocariz, J.; Biasini, M.; Manoni, E.; Pacetti, S.; Rossi, A.; Angelini, C.; Batignani, G.; Bettarini, S.; Carpinelli, M.; Casarosa, G.; Cervelli, A.; Chrzaszcz, M.; Forti, F.; Giorgi, M. A.; Lusiani, A.; Oberhof, B.; Paoloni, E.; Perez, A.; Rizzo, G.; Walsh, J. J.; Lopes Pegna, D.; Olsen, J.; Smith, A. J. S.; Faccini, R.; Ferrarotto, F.; Ferroni, F.; Gaspero, M.; Li Gioi, L.; Piredda, G.; Bünger, C.; Dittrich, S.; Grünberg, O.; Hartmann, T.; Hess, M.; Leddig, T.; Voß, C.; Waldi, R.; Adye, T.; Olaiya, E. O.; Wilson, F. F.; Emery, S.; Vasseur, G.; Anulli, F.; Aston, D.; Bard, D. J.; Cartaro, C.; Convery, M. R.; Dorfan, J.; Dubois-Felsmann, G. P.; Dunwoodie, W.; Ebert, M.; Field, R. C.; Fulsom, B. G.; Graham, M. T.; Hast, C.; Innes, W. R.; Kim, P.; Leith, D. W. G. S.; Lewis, P.; Lindemann, D.; Luitz, S.; Luth, V.; Lynch, H. L.; MacFarlane, D. B.; Muller, D. R.; Neal, H.; Perl, M.; Pulliam, T.; Ratcliff, B. N.; Roodman, A.; Salnikov, A. A.; Schindler, R. H.; Snyder, A.; Su, D.; Sullivan, M. K.; Va'vra, J.; Wisniewski, W. J.; Wulsin, H. W.; Purohit, M. V.; White, R. M.; Wilson, J. R.; Randle-Conde, A.; Sekula, S. J.; Bellis, M.; Burchat, P. R.; Puccio, E. M. T.; Alam, M. S.; Ernst, J. A.; Gorodeisky, R.; Guttman, N.; Peimer, D. R.; Soffer, A.; Spanier, S. M.; Ritchie, J. L.; Ruland, A. M.; Schwitters, R. F.; Wray, B. C.; Izen, J. M.; Lou, X. C.; Bianchi, F.; De Mori, F.; Filippi, A.; Gamba, D.; Lanceri, L.; Vitale, L.; Martinez-Vidal, F.; Oyanguren, A.; Villanueva-Perez, P.; Albert, J.; Banerjee, Sw.; Beaulieu, A.; Bernlochner, F. U.; Choi, H. H. F.; King, G. J.; Kowalewski, R.; Lewczuk, M. J.; Lueck, T.; Nugent, I. M.; Roney, J. M.; Sobie, R. J.; Tasneem, N.; Gershon, T. J.; Harrison, P. F.; Latham, T. E.; Band, H. R.; Dasu, S.; Pan, Y.; Prepost, R.; Wu, S. L.; BaBar Collaboration

    2014-05-01

    We study the processes e+e-→KS0KL0γ, KS0KL0π+π-γ, KS0KS0π+π-γ, and KS0KS0K+K-γ, where the photon is radiated from the initial state, providing cross section measurements for the hadronic states over a continuum of center-of-mass energies. The results are based on 469 fb-1 of data collected with the BABAR detector at SLAC. We observe the ϕ(1020) resonance in the KS0KL0 final state and measure the product of its electronic width and branching fraction with about 3% uncertainty. We present a measurement of the e +e-→KS0KL0 cross section in the energy range from 1.06 to 2.2 GeV and observe the production of a resonance at 1.67 GeV. We present the first measurements of the e+e-→KS0KL0π+π-, KS0KS0π+π-, and KS0KS0K+K- cross sections and study the intermediate resonance structures. We obtain the first observations of J/ψ decay to the KS0KL0π +π-, KS0KS0π+π-, and KS0KS0K+K- final states.

  15. Prediction Error Associated with the Perceptual Segmentation of Naturalistic Events

    ERIC Educational Resources Information Center

    Zacks, Jeffrey M.; Kurby, Christopher A.; Eisenberg, Michelle L.; Haroutunian, Nayiri

    2011-01-01

    Predicting the near future is important for survival and plays a central role in theories of perception, language processing, and learning. Prediction failures may be particularly important for initiating the updating of perceptual and memory systems and, thus, for the subjective experience of events. Here, we asked observers to make predictions…

  16. History of Dropout-Prevention Events in AISD: Executive Summary.

    ERIC Educational Resources Information Center

    Frazer, Linda; And Others

    This report presents major drop-out prevention events in the Austin (Texas) Independent School District (AISD) since these efforts were initiated in 1982 by the Office of Research and Evaluation (ORE). The following are the major findings of the report: (1) the ORE has been researching and studying the dropout problem since 1982-83, and the effort…

  17. Dynamic Triggering of Microseismic Events

    NASA Astrophysics Data System (ADS)

    Lu, H.; Van der Baan, M.

    2015-12-01

    Microseismic events are commonly recorded during hydraulic fracturing experiments. In microseismic interpretations, each event is often regarded as independent and uncorrelated to neighboring ones. In reality, both the rock deformation (static stresses) and transient wave motion (dynamic stresses) associated with microseismic events add to the stress field together with the external loading (fluid injection). We believe the resulting static and dynamic stress perturbations will influence both the timing and spatial evolution of the microseismic cloud. We study the dynamic triggering of microseismicity using numerical simulations of a biaxial deformation test by means of a bonded particle method (Potyondy and Cundall, 2004), where crack development can be tracked and analyzed independently. Our methodology is to compare the stress changes due to one specific event with the occurrence of the next few events in the numerical simulations. In addition, we compute the dynamic stress perturbations for recorded large events analytically given their (non-double couple) failure mechanisms. Our results show that cracks following a major event tend to form in zones affected by the dynamic stresses by promoting new failure in areas that are critically stressed. This confirms that dynamic triggering during hydraulic fracturing operations but also larger scale seismicity is likely. It also demonstrates the often complex interplay between the dynamic and static stress changes and their effect on the temporal and spatial evolution of rock deformation at all scales.

  18. Brazilian Nanotechnology Initiative

    NASA Astrophysics Data System (ADS)

    Fazzio, Adalberto

    2015-03-01

    In Brazil there is intense research activity in nanotechnology, most of these developed in universities and research institutes. The Brazilian Nanotechnology Initiative (BNI) aims to integrate government actions to promote the competitiveness of the Brazilian industry. This initiative is founded on support for research and development in the laboratories of the National Laboratories for Nanotechnology (SisNANO), starting from an improvement in infrastructure and opening of laboratories for users of academia and business, promoting interaction and transfer knowledge between academia and business. Country currently has 26 thematic networks of nanotechnology, 16 -Virtual-National Institutes of Technology, seven National- Laboratories and 18 Associate Laboratories, which comprise the SisNANO. Seeking to expand and share governance with other government actors, the Interministries Committee for Nanotechnology was set up, composed of 10 ministries, and has the task of coordinating the entire program of the Federal Government Nanotechnology.Cooperation activities are an important part of BNI. Currently Brazil has cooperation programs with U.S., China, Canada and European Union among others. Recently, Brazil decided to join the European NanoReg program where 60 research groups are joining efforts to provide protocols and standards that can help regulatory agencies and governments.

  19. Initiatives for proliferation prevention

    SciTech Connect

    1997-04-01

    Preventing the proliferation of weapons of mass destruction is a central part of US national security policy. A principal instrument of the Department of Energy`s (DOE`s) program for securing weapons of mass destruction technology and expertise and removing incentives for scientists, engineers and technicians in the newly independent states (NIS) of the former Soviet Union to go to rogue countries or assist terrorist groups is the Initiatives for Proliferation Prevention (IPP). IPP was initiated pursuant to the 1994 Foreign Operations Appropriations Act. IPP is a nonproliferation program with a commercialization strategy. IPP seeks to enhance US national security and to achieve nonproliferation objectives by engaging scientists, engineers and technicians from former NIS weapons institutes; redirecting their activities in cooperatively-developed, commercially viable non-weapons related projects. These projects lead to commercial and economic benefits for both the NIS and the US IPP projects are funded in Russian, Ukraine, Kazakhstan and Belarus. This booklet offers an overview of the IPP program as well as a sampling of some of the projects which are currently underway.

  20. Precision flyer initiator

    DOEpatents

    Frank, A.M.; Lee, R.S.

    1998-05-26

    A precision flyer initiator forms a substantially spherical detonation wave in a high explosive (HE) pellet. An explosive driver, such as a detonating cord, a wire bridge circuit or a small explosive, is detonated. A flyer material is sandwiched between the explosive driver and an end of a barrel that contains an inner channel. A projectile or ``flyer`` is sheared from the flyer material by the force of the explosive driver and projected through the inner channel. The flyer than strikes the HE pellet, which is supported above a second end of the barrel by a spacer ring. A gap or shock decoupling material delays the shock wave in the barrel from predetonating the HE pellet before the flyer. A spherical detonation wave is formed in the HE pellet. Thus, a shock wave traveling through the barrel fails to reach the HE pellet before the flyer strikes the HE pellet. The precision flyer initiator can be used in mining devices, well-drilling devices and anti-tank devices. 10 figs.

  1. Precision flyer initiator

    DOEpatents

    Frank, Alan M.; Lee, Ronald S.

    1998-01-01

    A precision flyer initiator forms a substantially spherical detonation wave in a high explosive (HE) pellet. An explosive driver, such as a detonating cord, a wire bridge circuit or a small explosive, is detonated. A flyer material is sandwiched between the explosive driver and an end of a barrel that contains an inner channel. A projectile or "flyer" is sheared from the flyer material by the force of the explosive driver and projected through the inner channel. The flyer than strikes the HE pellet, which is supported above a second end of the barrel by a spacer ring. A gap or shock decoupling material delays the shock wave in the barrel from predetonating the HE pellet before the flyer. A spherical detonation wave is formed in the HE pellet. Thus, a shock wave traveling through the barrel fails to reach the HE pellet before the flyer strikes the HE pellet. The precision flyer initiator can be used in mining devices, well-drilling devices and anti-tank devices.

  2. Strategic defense initiative

    SciTech Connect

    Nichols, J.P.

    1985-01-01

    The Engineering Technology Division has a leading role, including that of program management, in a major new programmatic thrust of the Oak Ridge National Laboratory that is in support of the national Strategic Defense Initiative (SDI). It is appropriate for the Laboratory to become significantly involved in the program because several of the most promising SDI technologies are in areas for which ORNL (together with Y-12 and K-25) have strong capabilities and significant resources. The initial ORNL work in support of the SDI program is focused on three technologies in which ORNL has extensive experience and traditionally strong research and development programs: (1) space nuclear power, (2) flywheel energy storage, and (3) neutral particle beams. The space nuclear program will utilize our capabilities in areas such as refractory materials, high-temperature alkali metal systems, shielding, and instrumentation. Space nuclear reactors capable of supplying multimegawatt levels of electrical power on a continuous and long-term basis are envisioned to be required for a variety of SDI surveillance satellites and space-borne weapons platforms. The feasibility of an alkali metal Rankine power conversion cycle, which has promise of providing high power with a very low system mass, is planned for study.

  3. 70S-scanning initiation is a novel and frequent initiation mode of ribosomal translation in bacteria

    PubMed Central

    Yamamoto, Hiroshi; Wittek, Daniela; Gupta, Romi; Qin, Bo; Ueda, Takuya; Krause, Roland; Yamamoto, Kaori; Albrecht, Renate; Pech, Markus; Nierhaus, Knud H.

    2016-01-01

    According to the standard model of bacterial translation initiation, the small ribosomal 30S subunit binds to the initiation site of an mRNA with the help of three initiation factors (IF1–IF3). Here, we describe a novel type of initiation termed “70S-scanning initiation,” where the 70S ribosome does not necessarily dissociate after translation of a cistron, but rather scans to the initiation site of the downstream cistron. We detailed the mechanism of 70S-scanning initiation by designing unique monocistronic and polycistronic mRNAs harboring translation reporters, and by reconstituting systems to characterize each distinct mode of initiation. Results show that 70S scanning is triggered by fMet-tRNA and does not require energy; the Shine–Dalgarno sequence is an essential recognition element of the initiation site. IF1 and IF3 requirements for the various initiation modes were assessed by the formation of productive initiation complexes leading to synthesis of active proteins. IF3 is essential and IF1 is highly stimulating for the 70S-scanning mode. The task of IF1 appears to be the prevention of untimely interference by ternary aminoacyl (aa)-tRNA•elongation factor thermo unstable (EF-Tu)•GTP complexes. Evidence indicates that at least 50% of bacterial initiation events use the 70S-scanning mode, underscoring the relative importance of this translation initiation mechanism. PMID:26888283

  4. Very long apnea events in preterm infants.

    PubMed

    Mohr, Mary A; Vergales, Brooke D; Lee, Hoshik; Clark, Matthew T; Lake, Douglas E; Mennen, Anne C; Kattwinkel, John; Sinkin, Robert A; Moorman, J Randall; Fairchild, Karen D; Delos, John B

    2015-03-01

    Apnea is nearly universal among very low birth weight (VLBW) infants, and the associated bradycardia and desaturation may have detrimental consequences. We describe here very long (>60 s) central apnea events (VLAs) with bradycardia and desaturation, discovered using a computerized detection system applied to our database of over 100 infant years of electronic signals. Eighty-six VLAs occurred in 29 out of 335 VLBW infants. Eighteen of the 29 infants had a clinical event or condition possibly related to the VLA. Most VLAs occurred while infants were on nasal continuous positive airway pressure, supplemental oxygen, and caffeine. Apnea alarms on the bedside monitor activated in 66% of events, on average 28 s after cessation of breathing. Bradycardia alarms activated late, on average 64 s after cessation of breathing. Before VLAs oxygen saturation was unusually high, and during VLAs oxygen saturation and heart rate fell unusually slowly. We give measures of the relative severity of VLAs and theoretical calculations that describe the rate of decrease of oxygen saturation. A clinical conclusion is that very long apnea (VLA) events with bradycardia and desaturation are not rare. Apnea alarms failed to activate for about one-third of VLAs. It appears that neonatal intensive care unit (NICU) personnel respond quickly to bradycardia alarms but not consistently to apnea alarms. We speculate that more reliable apnea detection systems would improve patient safety in the NICU. A physiological conclusion is that the slow decrease of oxygen saturation is consistent with a physiological model based on assumed high values of initial oxygen saturation.

  5. Very long apnea events in preterm infants

    PubMed Central

    Vergales, Brooke D.; Lee, Hoshik; Clark, Matthew T.; Lake, Douglas E.; Mennen, Anne C.; Kattwinkel, John; Sinkin, Robert A.; Moorman, J. Randall; Fairchild, Karen D.; Delos, John B.

    2014-01-01

    Apnea is nearly universal among very low birth weight (VLBW) infants, and the associated bradycardia and desaturation may have detrimental consequences. We describe here very long (>60 s) central apnea events (VLAs) with bradycardia and desaturation, discovered using a computerized detection system applied to our database of over 100 infant years of electronic signals. Eighty-six VLAs occurred in 29 out of 335 VLBW infants. Eighteen of the 29 infants had a clinical event or condition possibly related to the VLA. Most VLAs occurred while infants were on nasal continuous positive airway pressure, supplemental oxygen, and caffeine. Apnea alarms on the bedside monitor activated in 66% of events, on average 28 s after cessation of breathing. Bradycardia alarms activated late, on average 64 s after cessation of breathing. Before VLAs oxygen saturation was unusually high, and during VLAs oxygen saturation and heart rate fell unusually slowly. We give measures of the relative severity of VLAs and theoretical calculations that describe the rate of decrease of oxygen saturation. A clinical conclusion is that very long apnea (VLA) events with bradycardia and desaturation are not rare. Apnea alarms failed to activate for about one-third of VLAs. It appears that neonatal intensive care unit (NICU) personnel respond quickly to bradycardia alarms but not consistently to apnea alarms. We speculate that more reliable apnea detection systems would improve patient safety in the NICU. A physiological conclusion is that the slow decrease of oxygen saturation is consistent with a physiological model based on assumed high values of initial oxygen saturation. PMID:25549762

  6. Status of Monte-Carlo Event Generators

    SciTech Connect

    Hoeche, Stefan; /SLAC

    2011-08-11

    Recent progress on general-purpose Monte-Carlo event generators is reviewed with emphasis on the simulation of hard QCD processes and subsequent parton cascades. Describing full final states of high-energy particle collisions in contemporary experiments is an intricate task. Hundreds of particles are typically produced, and the reactions involve both large and small momentum transfer. The high-dimensional phase space makes an exact solution of the problem impossible. Instead, one typically resorts to regarding events as factorized into different steps, ordered descending in the mass scales or invariant momentum transfers which are involved. In this picture, a hard interaction, described through fixed-order perturbation theory, is followed by multiple Bremsstrahlung emissions off initial- and final-state and, finally, by the hadronization process, which binds QCD partons into color-neutral hadrons. Each of these steps can be treated independently, which is the basic concept inherent to general-purpose event generators. Their development is nowadays often focused on an improved description of radiative corrections to hard processes through perturbative QCD. In this context, the concept of jets is introduced, which allows to relate sprays of hadronic particles in detectors to the partons in perturbation theory. In this talk, we briefly review recent progress on perturbative QCD in event generation. The main focus lies on the general-purpose Monte-Carlo programs HERWIG, PYTHIA and SHERPA, which will be the workhorses for LHC phenomenology. A detailed description of the physics models included in these generators can be found in [8]. We also discuss matrix-element generators, which provide the parton-level input for general-purpose Monte Carlo.

  7. Developing an event stratigraphy for Heinrich Event 4 at Eirik Drift, South of Greenland

    NASA Astrophysics Data System (ADS)

    Stanford, Jennifer; Abbott, Peter; Davies, Siwan

    2014-05-01

    Heinrich events are characterised in North Atlantic sediments by horizons with increased Ice Rafted Debris (IRD) concentrations, low foraminiferal abundances, and light planktonic foraminiferal calcite δ18O (meltwater dilution). They occurred quasi-periodically with a spacing of 5,000-14,000 yrs (Hemming, 2004). It is commonly believed that large iceberg/meltwater injections likely caused slowdowns of the Atlantic Meridional Overturning Circulation (AMOC). However, Stanford et al. (2011) showed, using a basin-wide reconstruction of Heinrich Event 1 (~19-15 ka BP), which was based upon marine and terrestrial records on carefully scrutinised age models, that the main iceberg discharge event occurred some ~1000 years after the initial AMOC slowdown. The study highlighted the importance of robust chronological constraints in order to permit the development of a process understanding of the evolution of such climate events, by evaluation of statistical uncertainty and robust quantification of leads and lags in the ocean-climate system. Here, we present initial results from a marine sediment core recovered from Eirik Drift, South of Greenland, that span the time period that encompasses Heinrich Event 4 (35-45 ka BP). Today, sediments on Eirik Drift are deposited and reworked by the Deep Western Boundary Current (DWBC) and are also located beneath the pathway of the East Greenland and East Greenland Coastal Currents. Hence, Eirik Drift is a crucial monitoring site of surface and deep waters that exit the Arctic via the Denmark Strait. We here combine a proxy record for North Atlantic Deep Water (NADW) flow intensity (κARM/κ) with co-registered records of surface water conditions and place these on a palaeomagnetic and tephrochronologic stratigraphic framework. Given that this chronological framework is independent of environmental influences, basin-wide signal comparison is therefore permissible. Hemming, S. R. (2004), Heinrich Events: Massive Late Pleistocene detritus

  8. Digital Instrumentation and Control Failure Events Derivation and Analysis by Frame-Based Technique

    SciTech Connect

    Hui-Wen Huang; Chunkuan Shih; Swu Yih; Yen-Chang Tzeng; Ming-Huei Chen

    2006-07-01

    A frame-based technique, including physical frame, logical frame, and cognitive frame, was adopted to perform digital I and C failure events derivation and analysis for generic ABWR. The physical frame was structured with a modified PCTran-ABWR plant simulation code, which was extended and enhanced on the feedwater system, recirculation system, and steam line system. The logical model is structured with MATLAB, which was incorporated into PCTran-ABWR to improve the pressure control system, feedwater control system, recirculation control system, and automated power regulation control system. As a result, the software failure of these digital control systems can be properly simulated and analyzed. The cognitive frame was simulated by the operator awareness status in the scenarios. Moreover, via an internal characteristics tuning technique, the modified PCTran-ABWR can precisely reflect the characteristics of the power-core flow. Hence, in addition to the transient plots, the analysis results can then be demonstrated on the power-core flow map. A number of postulated I and C system software failure events were derived to achieve the dynamic analyses. The basis for event derivation includes the published classification for software anomalies, the digital I and C design data for ABWR, chapter 15 accident analysis of generic SAR, and the reported NPP I and C software failure events. The case study of this research includes (1) the software CMF analysis for the major digital control systems; and (2) postulated ABWR digital I and C software failure events derivation from the actual happening of non-ABWR digital I and C software failure events, which were reported to LER of USNRC or IRS of IAEA. These events were analyzed by PCTran-ABWR. Conflicts among plant status, computer status, and human cognitive status are successfully identified. The operator might not easily recognize the abnormal condition, because the computer status seems to progress normally. However, a well

  9. Periodicity in marine extinction events

    NASA Technical Reports Server (NTRS)

    Sepkoski, J. John, Jr.; Raup, David M.

    1986-01-01

    The periodicity of extinction events is examined in detail. In particular, the temporal distribution of specific, identifiable extinction events is analyzed. The nature and limitations of the data base on the global fossil record is discussed in order to establish limits of resolution in statistical analyses. Peaks in extinction intensity which appear to differ significantly from background levels are considered, and new analyses of the temporal distribution of these peaks are presented. Finally, some possible causes of periodicity and of interdependence among extinction events over the last quarter billion years of earth history are examined.

  10. Responding to the Event Deluge

    NASA Technical Reports Server (NTRS)

    Williams, Roy D.; Barthelmy, Scott D.; Denny, Robert B.; Graham, Matthew J.; Swinbank, John

    2012-01-01

    We present the VOEventNet infrastructure for large-scale rapid follow-up of astronomical events, including selection, annotation, machine intelligence, and coordination of observations. The VOEvent.standard is central to this vision, with distributed and replicated services rather than centralized facilities. We also describe some of the event brokers, services, and software that .are connected to the network. These technologies will become more important in the coming years, with new event streams from Gaia, LOF AR, LIGO, LSST, and many others

  11. Early traumatic events in psychopaths.

    PubMed

    Borja, Karina; Ostrosky, Feggy

    2013-07-01

    The relationship between diverse early traumatic events and psychopathy was studied in 194 male inmates. Criminal history transcripts were revised, and clinical interviews were conducted to determine the level of psychopathy using the Psychopathy Checklist-Revised (PCL-R) Form, and the Early Trauma Inventory was applied to assess the incidence of abuse before 18 years of age. Psychopathic inmates presented a higher victimization level and were more exposed to certain types of intended abuse than sociopathic inmates, while the sum of events and emotional abuse were associated with the PCL-R score. Our studies support the influence of early adverse events in the development of psychopathic offenders.

  12. Stimuli, Reinforcers, and Private Events

    PubMed Central

    Nevin, John A

    2008-01-01

    Radical behaviorism considers private events to be a part of ongoing observable behavior and to share the properties of public events. Although private events cannot be measured directly, their roles in overt action can be inferred from mathematical models that relate private responses to external stimuli and reinforcers according to the same quantitative relations that characterize public operant behavior. This approach is illustrated by a model of attending to stimuli and to anticipated reinforcers in delayed matching to sample, in which the probabilities of attending are related to reinforcer rates by an expression derived from research on behavioral momentum. PMID:22478505

  13. The 2012 July 23 Backside Eruption: An Extreme Energetic Particle Event?

    NASA Astrophysics Data System (ADS)

    Gopalswamy, N.; Yashiro, S.; Thakur, N.; Mäkelä, P.; Xie, H.; Akiyama, S.

    2016-12-01

    The backside coronal mass ejection (CME) of 2012 July 23 had a short Sun-to-Earth shock transit time (18.5 hr). The associated solar energetic particle (SEP) event had a >10 MeV proton flux peaking at ˜5000 pfu, and the energetic storm particle event was an order of magnitude larger, making it the most intense event in the space era at these energies. By a detailed analysis of the CME, shock, and SEP characteristics, we find that the July 23 event is consistent with a high-energy SEP event (accelerating particles to gigaelectronvolt energies). The times of maximum and fluence spectra in the range 10-100 MeV were very hard, similar to those of ground-level enhancement (GLE) events. We found a hierarchical relationship between the CME initial speeds and the fluence spectral indices: CMEs with low initial speeds had SEP events with the softest spectra, while those with the highest initial speeds had SEP events with the hardest spectra. CMEs attaining intermediate speeds result in moderately hard spectra. The July 23 event was in the group of hard-spectrum events. During the July 23 event, the shock speed (>2000 km s-1), the initial acceleration (˜1.70 km s-2), and the shock-formation height (˜1.5 solar radii) were all typical of GLE events. The associated type II burst had emission components from meter to kilometer wavelengths, suggesting a strong shock. These observations confirm that the 2012 July 23 event is likely to be an extreme event in terms of the energetic particles it accelerated.

  14. Instrumented Pipeline Initiative

    SciTech Connect

    Thomas Piro; Michael Ream

    2010-07-31

    This report summarizes technical progress achieved during the cooperative agreement between Concurrent Technologies Corporation (CTC) and U.S. Department of Energy to address the need for a for low-cost monitoring and inspection sensor system as identified in the Department of Energy (DOE) National Gas Infrastructure Research & Development (R&D) Delivery Reliability Program Roadmap.. The Instrumented Pipeline Initiative (IPI) achieved the objective by researching technologies for the monitoring of pipeline delivery integrity, through a ubiquitous network of sensors and controllers to detect and diagnose incipient defects, leaks, and failures. This report is organized by tasks as detailed in the Statement of Project Objectives (SOPO). The sections all state the objective and approach before detailing results of work.

  15. [Advanced Composites Technology Initiatives

    NASA Technical Reports Server (NTRS)

    Julian, Mark R.

    2002-01-01

    This final report closes out the W02 NASA Grant #NCC5-646. The FY02 grant for advanced technology initiatives through the Advanced Composites Technology Institute in Bridgeport, WV, at the Robert C. Byrd Institute (RCBI) Bridgeport Manufacturing Technology Center, is complete; all funding has been expended. RCBI continued to expand access to technology; develop and implement a workforce-training curriculum; improve material development; and provide prototyping and demonstrations of new and advanced composites technologies for West Virginia composites firms. The FY 02 efforts supported workforce development, technical training and the HST development effort of a super-lightweight composite carrier prototype and expanded the existing technical capabilities of the growing aerospace industry across West Virginia to provide additional support for NASA missions. Additionally, the Composites Technology and Training Center was awarded IS0 9001 - 2000 certification and Cleanroom Class 1000 certification during this report period.

  16. The Knowledge Stealing Initiative?

    NASA Technical Reports Server (NTRS)

    Goshorn, Larry

    2005-01-01

    I have the honor of being on the Academy of Program and Project Leadership (APPL) Knowledge Sharing Feedback and Assessment Team (FAA), and as such, I am privileged to receive the feedback written by many of you as attendees of the Project Management (PM) Master s Forums. It is the intent of the FAA Team and APPL leadership to use this feedback as a tool for continuous program improvement. As a retired (sort of) PM in the payload contracting industry, I'm a big supporter of NASA s Knowledge Sharing Initiative (KSI), especially the Master's Forums. I really enjoy participating in them. Unfortunately I had to miss the 8th forum in Pasadena this past Spring, but I did get the feedback package for the Assessment Team work. So here I was, reviewing twelve pages of comments, reflections, learning notes and critiques from attendees of the 8th forum.

  17. Quality initiative at ESO

    NASA Astrophysics Data System (ADS)

    Rupprecht, Gero; Arsenault, Robin; Hanuschik, Reinhard; Kraus, Maximilian; Sivera, Paola; Tromp, Arnout; Verzichelli, Gianluca

    2016-08-01

    An initiative is under way at ESO Headquarters to optimise operations, in particular in the engineering, technical and associated management areas. A systematic approach to strengthen the operating processes is in preparation, starting with a mapping of the extensive existing process network. Processes identified as sufficiently important and complex to merit an in-depth analysis will be properly specified and their implementation optimised to strike a sensible balance between organisational overhead (documentation) and efficiency. By applying methods and tools tried and tested in industry we expect to achieve a more unified approach to address recurrent tasks. This will enable staff to concentrate more on new challenges and improvement and avoid spending effort on issues already resolved in the past.

  18. Breckinridge Project, initial effort

    SciTech Connect

    None, None

    1982-09-01

    Report III, Volume 1 contains those specifications numbered A through J, as follows: General Specifications (A); Specifications for Pressure Vessels (C); Specifications for Tanks (D); Specifications for Exchangers (E); Specifications for Fired Heaters (F); Specifications for Pumps and Drivers (G); and Specifications for Instrumentation (J). The standard specifications of Bechtel Petroleum Incorporated have been amended as necessary to reflect the specific requirements of the Breckinridge Project, and the more stringent specifications of Ashland Synthetic Fuels, Inc. These standard specifications are available to the Initial Effort (Phase Zero) work performed by all contractors and subcontractors. Report III, Volume 1 also contains the unique specifications prepared for Plants 8, 15, and 27. These specifications will be substantially reviewed during Phase I of the project, and modified as necessary for use during the engineering, procurement, and construction of this project.

  19. An Archean Biosphere Initiative

    NASA Technical Reports Server (NTRS)

    Anbar, A. D.; Boyd, E. S.; Buick, R.; Claire, M.; DesMarais, D.; Domagal-Goldman, D.; Eigenbrode, J.; Erwin, D.; Freeman, K.; Hazen, R.; Johnson, C.; Lyons, T.; Meadows, V.; Ohmoto, H.; Ono, S.; Peters, J. W.; Shapiro, B.; Summons, R.; Walter, M.

    2011-01-01

    The search for life on extrasolar planets will necessarily focus on the imprints of biolgy on the composition of planetary atmospheres. The most notable biological imprint on the modern terrestrial atmosphere is the presence of 21 % O2, However, during most of the past 4 billion years, life and the surface environments on Earth were profoundly different than they are today. It is therefore a major goal of the astrobiology community to ascertain how the O2 content of the atmosphere has varied with time. and to understand the causes of these variations. The NAI and NASA Exobiology program have played critical roles in developing our current understanding of the ancient Earth's atmosphere, supporting diverse observational, analytical, and computational research in geoscience, life science, and related fields. In the present incarnation of the NAI, ongoing work is investigating (i) variations in atmospheric O2 in the Archean to the Cambrian, (ii) characterization of the redox state of the oceans shortly before, during and after the Great Oxidation Event (GOE), and (iii) unraveling the complex connections between environmental oxygenation, global climate, and the evolution of life.

  20. Sustainable Biosphere Initiative Project

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The goal of the Advanced Technology in Ecological Sciences project is to gain broad participation within the environmental scientific community in developing a research agenda addressing the development and refinement of technologies instrumental to research that responds to these challenges (e.g. global climate change, unsustainable resource use, and threats to biological diversity). The following activities have been completed: (1) A listserve 'eco-tech was set up to serve as a clearinghouse of information about activities and events relating to advanced technologies; (2) A series of conference calls were organized on specific topics including data visualization and spatial analysis, and remote sensing; and (3) Two meetings were organized at the 19% ESA Annual Meeting in Providence, Rhode Island. Topics covered included concerns about tool and data sharing; interest in expanded development of ground-based remote sensing technologies for monitoring; issues involved in training for using new technologies and increasing data streams, and- associated implications of data processing capabilities; questions about how to develop appropriate standards (i.e. surface morphology classification standards) that facilitate the exchange and comparison of analytical results; and some thoughts about remote sensing platforms and vehicles.

  1. Coping with a Traumatic Event

    MedlinePlus

    ... have seen the event either firsthand or on television. What Are Some Common Responses? A person’s response ... and interventions after disasters and acts of mass violence. http://www.nimh.nih.gov/ Posttraumatic Stress Disorder ( ...

  2. Wrappers, Aspects, Quantification and Events

    NASA Technical Reports Server (NTRS)

    Filman, Robert E.

    2005-01-01

    Talk overview: Object infrastructure framework (OIF). A system development to simplify building distributed applications by allowing independent implementation of multiple concern. Essence and state of AOP. Trinity. Quantification over events. Current work on a generalized AOP technology.

  3. MGR External Events Hazards Analysis

    SciTech Connect

    L. Booth

    1999-11-06

    The purpose and objective of this analysis is to apply an external events Hazards Analysis (HA) to the License Application Design Selection Enhanced Design Alternative 11 [(LADS EDA II design (Reference 8.32))]. The output of the HA is called a Hazards List (HL). This analysis supersedes the external hazards portion of Rev. 00 of the PHA (Reference 8.1). The PHA for internal events will also be updated to the LADS EDA II design but under a separate analysis. Like the PHA methodology, the HA methodology provides a systematic method to identify potential hazards during the 100-year Monitored Geologic Repository (MGR) operating period updated to reflect the EDA II design. The resulting events on the HL are candidates that may have potential radiological consequences as determined during Design Basis Events (DBEs) analyses. Therefore, the HL that results from this analysis will undergo further screening and analysis based on the criteria that apply during the performance of DBE analyses.

  4. Brief resolved unexplained event -- BRUE

    MedlinePlus

    ... a change in muscle tone, turns pale or blue in color, or is unresponsive. The event occurs ... the child stopped breathing, turned pale, or had blue coloring Feeding problems Recent head cold or bronchitis ...

  5. MONTANA PALLADIUM RESEARCH INITIATIVE

    SciTech Connect

    Peters, John; McCloskey, Jay; Douglas, Trevor; Young, Mark; Snyder, Stuart; Gurney, Brian

    2012-05-09

    Project Objective: The overarching objective of the Montana Palladium Research Initiative is to perform scientific research on the properties and uses of palladium in the context of the U.S. Department of Energy's Hydrogen, Fuel Cells and Infrastructure Technologies Program. The purpose of the research will be to explore possible palladium as an alternative to platinum in hydrogen-economy applications. To achieve this objective, the Initiatives activities will focus on several cutting-edge research approaches across a range of disciplines, including metallurgy, biomimetics, instrumentation development, and systems analysis. Background: Platinum-group elements (PGEs) play significant roles in processing hydrogen, an element that shows high potential to address this need in the U.S. and the world for inexpensive, reliable, clean energy. Platinum, however, is a very expensive component of current and planned systems, so less-expensive alternatives that have similar physical properties are being sought. To this end, several tasks have been defined under the rubric of the Montana Palladium Research Iniative. This broad swath of activities will allow progress on several fronts. The membrane-related activities of Task 1 employs state-of-the-art and leading-edge technologies to develop new, ceramic-substrate metallic membranes for the production of high-purity hydrogen, and develop techniques for the production of thin, defect-free platinum group element catalytic membranes for energy production and pollution control. The biomimetic work in Task 2 explores the use of substrate-attached hydrogen-producing enzymes and the encapsulation of palladium in virion-based protein coats to determine their utility for distributed hydrogen production. Task 3 work involves developing laser-induced breakdown spectroscopy (LIBS) as a real-time, in situ diagnostic technique to characterize PGEs nanoparticles for process monitoring and control. The systems engineering work in task 4 will

  6. Green Power Initiative

    SciTech Connect

    Butler, Patrick Barry

    2013-01-28

    National energy policy supports the gathering of more detailed and authoritative data on the introduction of renewable bio-based fuels into new and existing district energy systems via the application of biomass gasification. The University of Iowa developed a biomass-fueled, university-scale steam generation system based on biomass gasification technologies. The system serves as a state-of-the-art research and educational facility in the emerging application of gasification in steam generation. The facility, which includes a smaller down-draft gasifier and a larger multi-stage biomass boiler, was designed to operate primarily on wood-based fuels, but has provisions for testing other biomass fuel sources produced within a 100-mile radius, providing enough flexibility to meet the fluctuating local supply of biomass from industry and Midwest agriculture. The equipment was installed in an existing, staffed facility. The down-draft gasifier unit is operated by College of Engineering staff and students, under the direct technical supervision of qualified Utilities plant staff. The Green Power Initiative also includes a substantial, innovative educational component. In addition to an onsite, graduate-level research program in biomass fuels, the investigators have integrated undergraduate and graduate level teaching – through classroom studies and experiential learning – and applied research into a biomass-based, university-scale, functioning power plant. University of Iowa is unique in that it currently has multiple renewable energy technologies deployed, including significant biomass combustion (oat hulls) at its Main Power Plant and a new reciprocating engine based renewable district energy system. This project complements and supports the national energy policy and State of Iowa initiatives in ethanol and biodiesel. Byproducts of ethanol and biodiesel processes (distiller grains) as well as industry residues (oat hulls, wood chips, construction and demolition

  7. Safe motherhood: the FIGO initiative.

    PubMed

    Benagiano, G; Thomas, B

    2003-09-01

    Over the last twenty years the international community-realizing that the tragedy of women dying during pregnancy and in childbirth could no longer be tolerated-launched a series of initiatives aimed at making safe motherhood a cornerstone of health services in all countries. Making pregnancy and delivery safe events is particularly complex, as it involves infrastructural and logistic, as well as technical, issues. Women die because they have no access to skilled personnel during pregnancy and at the time of delivery and because--if an emergency situation arises--they cannot reach a facility where emergency obstetric services are available. FIGO, the International Federation of Obstetrics and Gynecology-as the only global organization representing the Obstetricians of the world-decided some time ago that it could not limit its activities to proposing technical guidelines and debating scientific issues. It had to move into the field and, through its affiliated societies, help change the ability of the multitude of women in the developing world to obtain skilled attendance at birth. In 1997, plans were made to launch activities in five areas where maternal mortality was particularly high: Central America (Guatemala, Honduras, Nicaragua and El Salvador), Ethiopia, Mozambique, Pakistan, and Uganda. Five member societies from the developed world (the American College of Obstetricians and Gynecologists, the Society of Obstetricians and Gynecologists of Canada, the Italian Society of Obstetrics and Gynecology, the Royal College of Obstetricians and Gynecologists of the United Kingdom; and the Swedish Society of Obstetrics and Gynecology) agreed to provide support to their counterparts in these five selected areas. The project is now in its final stage. Results are, by and large, positive, demonstrating that, by motivating health professionals in the field and for a relatively modest financial outlay, more efficient use of existing services could be made in a sustainable

  8. Pluto-charon mutual events

    SciTech Connect

    Binzel, R.P. )

    1989-11-01

    Since 1985, planetary astronomers have been working to take advantage of a once-per-century apparent alignment between Pluto and its satellite, Charon, which has allowed mutual occultation and transit events to be observed. There events, which will cease in 1990, have permitted the first precise determinations of their individual radii, densities, and surface compositions. In addition, information on their surface albedo distributions can be obtained.

  9. Measuring polarization in microlensing events

    NASA Astrophysics Data System (ADS)

    Ingrosso, G.; Calchi Novati, S.; De Paolis, F.; Jetzer, Ph.; Nucita, A. A.; Strafella, F.

    2015-01-01

    We reconsider the polarization of the star light that may arise during microlensing events due to the high gradient of magnification across the atmosphere of the source star, by exploring the full range of microlensing and stellar physical parameters. Since it is already known that only cool evolved giant stars give rise to the highest polarization signals, we follow the model by Simmons et al. to compute the polarization as due to the photon scattering on dust grains in the stellar wind. Motivated by the possibility to perform a polarization measurement during an ongoing microlensing event, we consider the recently reported event catalogue by the Optical Gravitational Lensing Experiment (OGLE) collaboration covering the 2001-2009 campaigns (OGLE-III events), that makes available the largest and more comprehensive set of single-lens microlensing events towards the Galactic bulge. The study of these events, integrated by a Monte Carlo analysis, allows us to estimate the expected polarization profiles and to predict for which source stars and at which time is most convenient to perform a polarization measurement in an ongoing event. We find that about two dozens of OGLE-III events (about 1 per cent of the total) have maximum polarization degree in the range 0.1 < Pmax < 1 per cent, corresponding to source stars with apparent magnitude I ≲ 14.5, being very cool red giants. This signal is measurable by using the FOcal Reducer and low dispersion Spectrograph (FORS2) polarimeter at Very Large Telescope (VLT) telescope with about 1 h integration time.

  10. Concurrency and discrete event control

    NASA Technical Reports Server (NTRS)

    Heymann, Michael

    1990-01-01

    Much of discrete event control theory has been developed within the framework of automata and formal languages. An alternative approach inspired by the theories of process-algebra as developed in the computer science literature is presented. The framework, which rests on a new formalism of concurrency, can adequately handle nondeterminism and can be used for analysis of a wide range of discrete event phenomena.

  11. Nuclear event zero-time calculation and uncertainty evaluation.

    PubMed

    Pan, Pujing; Ungar, R Kurt

    2012-04-01

    It is important to know the initial time, or zero-time, of a nuclear event such as a nuclear weapon's test, a nuclear power plant accident or a nuclear terrorist attack (e.g. with an improvised nuclear device, IND). Together with relevant meteorological information, the calculated zero-time is used to help locate the origin of a nuclear event. The zero-time of a nuclear event can be derived from measured activity ratios of two nuclides. The calculated zero-time of a nuclear event would not be complete without an appropriately evaluated uncertainty term. In this paper, analytical equations for zero-time and the associated uncertainty calculations are derived using a measured activity ratio of two nuclides. Application of the derived equations is illustrated in a realistic example using data from the last Chinese thermonuclear test in 1980.

  12. Fast drift kilometric radio bursts and solar proton events

    NASA Technical Reports Server (NTRS)

    Cliver, E. W.; Kahler, S. W.; Cane, H. V.; Mcguire, R. E.; Vonrosenvinge, T. T.; Stone, R. G.

    1985-01-01

    Initial results of a comparative study of major fast drift kilometric bursts and solar proton events from Sep. 1978 to Feb. 1983 are presented. It was found that only about half of all intense, long duration ( 40 min above 500 sfu) 1 MHz bursts can be associated with F 20 MeV proton events. However, for the subset of such fast drift bursts accompanied by metric Type 2 and/or 4 activity (approximately 40% of the total), the degree of association with 20 MeV events is 80%. For the reverse association, it was found that proton events with J( 20 MeV) 0.01 1 pr cm(-2)s(-1)sr(-1)MeV(-1) were typically (approximately 80% of the time) preceded by intense 1 MHz bursts that exceeded the 500 sfu level for times 20 min (median duration approximately 35 min).

  13. Event structure and cognitive control.

    PubMed

    Reimer, Jason F; Radvansky, Gabriel A; Lorsbach, Thomas C; Armendarez, Joseph J

    2015-09-01

    Recently, a great deal of research has demonstrated that although everyday experience is continuous in nature, it is parsed into separate events. The aim of the present study was to examine whether event structure can influence the effectiveness of cognitive control. Across 5 experiments we varied the structure of events within the AX-CPT by shifting the spatial location of cues and probes on a computer screen. When location shifts were present, a pattern of AX-CPT performance consistent with enhanced cognitive control was found. To test whether the location shift effects were caused by the presence of event boundaries per se, other aspects of the AX-CPT were manipulated, such as the color of cues and probes and the inclusion of a distractor task during the cue-probe delay. Changes in cognitive control were not found under these conditions, suggesting that the location shift effects were specifically related to the formation of separate event models. Together, these results can be accounted for by the Event Horizon Model and a representation-based theory of cognitive control, and suggest that cognitive control can be influenced by the surrounding environmental structure.

  14. Leptomeningeal metastasis as initial manifestation of signet ring colorectal adenocarcinoma: a case report with review of literature

    PubMed Central

    Assi, Rita; Hamieh, Lana; Mukherji, Deborah; Haydar, Ali; Temraz, Sally; El-Dika, Imane

    2015-01-01

    Leptomeningeal carcinomatosis (LMC) is an exceedingly rare event especially as a first manifestation of an occult primary colorectal cancer and even when there is a known history of malignancy. Sensorineural hearing loss is by itself an unusual isolated presentation of LMC with unsolved pathophysiology in this setting. In this paper, we report such a case and review the literature for similar cases, focusing on postulated mechanisms of spread. In view of the poor prognosis they carry, we highly recommend that physicians be aware of the risk of rare metastasis from colorectal adenocarcinoma in order to establish an early confirmative diagnosis. PMID:26697206

  15. Causal events enter awareness faster than non-causal events

    PubMed Central

    Wagemans, Johan; de-Wit, Lee

    2017-01-01

    Philosophers have long argued that causality cannot be directly observed but requires a conscious inference (Hume, 1967). Albert Michotte however developed numerous visual phenomena in which people seemed to perceive causality akin to primary visual properties like colour or motion (Michotte, 1946). Michotte claimed that the perception of causality did not require a conscious, deliberate inference but, working over 70 years ago, he did not have access to the experimental methods to test this claim. Here we employ Continuous Flash Suppression (CFS)—an interocular suppression technique to render stimuli invisible (Tsuchiya & Koch, 2005)—to test whether causal events enter awareness faster than non-causal events. We presented observers with ‘causal’ and ‘non-causal’ events, and found consistent evidence that participants become aware of causal events more rapidly than non-causal events. Our results suggest that, whilst causality must be inferred from sensory evidence, this inference might be computed at low levels of perceptual processing, and does not depend on a deliberative conscious evaluation of the stimulus. This work therefore supports Michotte’s contention that, like colour or motion, causality is an immediate property of our perception of the world. PMID:28149698

  16. Memories of traumatic events in childhood fade after experiencing similar less stressful events: results from two natural experiments.

    PubMed

    Weems, Carl F; Russell, Justin D; Banks, Donice M; Graham, Rebecca A; Neill, Erin L; Scott, Brandon G

    2014-10-01

    The long-term stability of youth reports of traumatic events is largely unknown. Translational animal research suggests that there may be an alteration of memories for traumatic events via memory reconsolidation processes, whereas clinical research suggests memory alteration may occur through augmentation by negative emotions. In this report, 2 natural experiments test reconsolidation model and augmentation model predictions about the course of traumatic memories in youth. Data are from 2 prospective studies that assessed reports of an initial traumatic event (Hurricane Katrina) and tested recall both pre and post a similar event (Hurricane Gustav). In the 1st (Sample 1; n = 94, initial Grade 9 followed to 11), youth were assessed at 4 time points: Times 1-3 were 13, 20, and 26 months post-Katrina and then Time 4 was 5 months post-Hurricane Gustav. In the 2nd (Sample 2; n = 141, Grades 4 through 8), youth were assessed at 12 months pre-Gustav (Time 1; 24 months post-Katrina) and then again at 1 month (Time 2) and 8 months (Time 3) post-Gustav. Those with relatively high Gustav exposure showed more stability in their reports of Katrina exposure events, whereas in those with low Gustav exposure, reports of Katrina events decreased. Time spans between recall, age, gender, symptoms of posttraumatic stress disorder, or cognitive/learning ability did not explain changes in the reports. The study provides the 1st long-term data on the consistency of youth reports of disaster-related experiences and provides initial evidence for the ecological validity of memory reconsolidation theory applied to traumatic events in youth.

  17. ELLIPTIC FLOW, INITIAL ECCENTRICITY AND ELLIPTIC FLOW FLUCTUATIONS IN HEAVY ION COLLISIONS AT RHIC.

    SciTech Connect

    NOUICER,R.; ALVER, B.; BACK, B.B.; BAKER, M.D.; BALLINTIJN, M.; BARTON, D.S.; ET AL.

    2007-02-19

    We present measurements of elliptic flow and event-by-event fluctuations established by the PHOBOS experiment. Elliptic flow scaled by participant eccentricity is found to be similar for both systems when collisions with the same number of participants or the same particle area density are compared. The agreement of elliptic flow between Au+Au and Cu+Cu collisions provides evidence that the matter is created in the initial stage of relativistic heavy ion collisions with transverse granularity similar to that of the participant nucleons. The event-by-event fluctuation results reveal that the initial collision geometry is translated into the final state azimuthal particle distribution, leading to an event-by-event proportionality between the observed elliptic flow and initial eccentricity.

  18. Transcript profiling of early lateral root initiation.

    PubMed

    Himanen, Kristiina; Vuylsteke, Marnik; Vanneste, Steffen; Vercruysse, Steven; Boucheron, Elodie; Alard, Philippe; Chriqui, Dominique; Van Montagu, Marc; Inzé, Dirk; Beeckman, Tom

    2004-04-06

    At the onset of lateral root initiation in Arabidopsis thaliana, the phytohormone auxin activates xylem pole pericycle cells for asymmetric cell division. However, the molecular events leading from auxin to lateral root initiation are poorly understood, in part because the few responsive cells in the process are embedded in the root and are thus difficult to access. A lateral root induction system, in which most xylem pole pericycle cells were synchronously activated by auxin transport inhibition followed by auxin application, was used for microarray transcript profiling. Of 4,600 genes analyzed, 906 significantly differentially regulated genes were identified that could be grouped into six major clusters. Basically, three major patterns were discerned representing induced, repressed, and transiently expressed genes. Analysis of the coregulated genes, which were specific for each time point, provided new insight into the molecular regulation and signal transduction preceding lateral root initiation in Arabidopsis. The reproducible expression profiles during a time course allowed us to define four stages that precede the cell division in the pericycle. These early stages were characterized by G1 cell cycle block, auxin perception, and signal transduction, followed by progression over G1/S transition and G2/M transition. All these processes took place within 6 h after transfer from N-1-naphthylphthalamic acid to 1-naphthalene acetic acid. These results indicate that this lateral root induction system represents a unique synchronized system that allows the systematic study of the developmental program upstream of the cell cycle activation during lateral root initiation.

  19. Consequence Prioritization Process for Potential High Consequence Events (HCE)

    SciTech Connect

    Freeman, Sarah G.

    2016-10-31

    This document describes the process for Consequence Prioritization, the first phase of the Consequence-Driven Cyber-Informed Engineering (CCE) framework. The primary goal of Consequence Prioritization is to identify potential disruptive events that would significantly inhibit an organization’s ability to provide the critical services and functions deemed fundamental to their business mission. These disruptive events, defined as High Consequence Events (HCE), include both events that have occurred or could be realized through an attack of critical infrastructure owner assets. While other efforts have been initiated to identify and mitigate disruptive events at the national security level, such as Presidential Policy Directive 41 (PPD-41), this process is intended to be used by individual organizations to evaluate events that fall below the threshold for a national security. Described another way, Consequence Prioritization considers threats greater than those addressable by standard cyber-hygiene and includes the consideration of events that go beyond a traditional continuity of operations (COOP) perspective. Finally, Consequence Prioritization is most successful when organizations adopt a multi-disciplinary approach, engaging both cyber security and engineering expertise, as in-depth engineering perspectives are required to recognize and characterize and mitigate HCEs. Figure 1 provides a high-level overview of the prioritization process.

  20. (α, γ) reaction induced background events for rare event experiments

    NASA Astrophysics Data System (ADS)

    Tiwari, Ashok; Zhang, Chao; Mei, Dongming

    2016-09-01

    We report an observation of (α, γ) reaction at the Soudan mine. With a 12-Liter scintillation neutron detector at Soudan mine for about 5 years of data taking, we have observed (α, γ) reaction, which can generate potential background events for dark matter and neutrinoless double-beta decay experiments. We have simulated the alpha flux from radon decay using the measured radon concentration in Soudan mine. The convolution of the alpha flux and the cross-section of (α, γ) allows us to determine the rate of high energy gamma from (α, γ) reaction. This rate is compared to the measured event rate. We demonstrate that the modulation of (α, γ) event rate has similar pattern as the radon modulation observed independently in Soudan mine. This work is supported by NSF in part by the NSF PHY-0758120, DOE Grant DE-FG02-10ER46709, and the State of South Dakota.