The future of textile production in high wage countries

NASA Astrophysics Data System (ADS)

Kemper, M.; Gloy, Y.-S.; Gries, T.

2017-10-01

It is undisputed that smart production in the context of industry 4.0 offers significant potential for industrial production in Germany. Exploiting this potential provides an opportunity to meet the growing competitive pressure for textile production in high-wage Germany. The complete cross-linking of textile mills towards Textile Production 4.0 means substantial savings. However, currently there are still some challenges that have to be overcome on the long way to Textile Production 4.0. This paper initially reflects the particular challenges of textile production in high-wage Germany. Later, the vision of the future of smart textile production will be outlined. In addition, first pilot solutions and current research approaches which pave the way for Textile Production 4.0 are described.

Critical overview of applications of genetic testing in sport talent identification.

PubMed

Roth, Stephen M

2012-12-01

Talent identification for future sport performance is of paramount interest for many groups given the challenges of finding and costs of training potential elite athletes. Because genetic factors have been implicated in many performance- related traits (strength, endurance, etc.), a natural inclination is to consider the addition of genetic testing to talent identification programs. While the importance of genetic factors to sport performance is generally not disputed, whether genetic testing can positively inform talent identification is less certain. The present paper addresses the science behind the genetic tests that are now commercially available (some under patent protection) and aimed at predicting future sport performance potential. Also discussed are the challenging ethical issues that emerge from the availability of these tests. The potential negative consequences associated with genetic testing of young athletes will very likely outweigh any positive benefit for sport performance prediction at least for the next several years. The paper ends by exploring the future possibilities for genetic testing as the science of genomics in sport matures over the coming decade(s).

Meeting the Needs of Children and Families: Opportunities and Challenges for School Psychology Training Programs.

ERIC Educational Resources Information Center

Curtis, Michael J.; Batsche, George M.

1991-01-01

Notes that graduate training programs face challenges, as well as opportunities, in fulfillment of their responsibilities to prepare school psychologists for entry into professional practice. Examines nature and origins of potential changes facing school psychology and discusses adequacy of current training programs. Discusses future implications…

The role of structural dynamics in the design and operations of space systems: The history, the lessons, the technical challenges of the future

NASA Technical Reports Server (NTRS)

Ryan, Robert S.

1994-01-01

Structural dynamics and its auxiliary fields are the most progressive and challenging areas space system engineering design and operations face. Aerospace systems are dependent on structural dynamicists for their success. Past experiences (history) are colored with many dynamic issues, some producing ground or flight test failures. The innovation and creativity that was brought to these issues and problems are the aura from the past that lights the path to the future. Using this illumination to guide understanding of the dynamic phenomena and designing for its potential occurrence are the keys to successful space systems. Our great paradox, or challenge, is how we remain in depth specialists, yet become generalists to the degree that we make good team members and set the right priorities. This paper will deal with how we performed with acclaim in the past, the basic characteristics of structural dynamics (loads cycle, for example), and the challenges of the future.

Medical oncology future plan of the Spanish Society of Medical Oncology: challenges and future needs of the Spanish oncologists.

PubMed

Rivera, F; Andres, R; Felip, E; Garcia-Campelo, R; Lianes, P; Llombart, A; Piera, J M; Puente, J; Rodriguez, C A; Vera, R; Virizuela, J A; Martin, M; Garrido, P

2017-04-01

The SEOM Future Plan is aimed at identifying the main challenges, trends and needs of the medical oncology speciality over the next years, including potential oncologist workforce shortages, and proposing recommendations to overcome them. The estimations of the required medical oncologists workforce are based on an updated Medical Oncologist Register in Spain, Medical Oncology Departments activity data, dedication times and projected cancer incidence. Challenges, needs and future recommendations were drawn from an opinion survey and an advisory board. A shortage of 211 FTE medical oncologist specialists has been established. To maintain an optimal ratio of 158 new cases/FTE, medical oncology workforce should reach 1881 FTE by 2035. Main recommendations to face the growing demand and complexity of oncology services include a yearly growth of 2.5% of medical oncologist's workforce until 2035, and development and application of more accurate quality indicators for cancer care and health outcomes measure.

Evaluating hydrological response of future land cover change scenarios in the San Pedro River (U.S./Mexico) with the automated geospatial watershed assessment (AGWA) tool

Treesearch

William G. Kepner; I. Shea Burns; David C Goodrich; D. Phillip Guertin; Gabriel S. Sidman; Lainie R. Levick; Wison W.S. Yee; Melissa M.A. Scianni; Clifton S. Meek; Jared B. Vollmer

2016-01-01

Long-term land-use and land cover change and their associated impacts pose critical challenges to sustaining vital hydrological ecosystem services for future generations. In this study, a methodology was developed to characterize potential hydrologic impacts from future urban growth through time. Future growth is represented by housing density maps generated in decadal...

Planetary Protection Technologies: Technical Challenges for Mars Exploration

NASA Technical Reports Server (NTRS)

Buxbaum, Karen L.

2005-01-01

The search for life in the solar system, using either in situ analysis or sample return, brings with it special technical challenges in the area of planetary protection. Planetary protection (PP) requires planetary explorers to preserve biological and organic conditions for future exploration and to protect the Earth from potential extraterrestrial contamination that could occur as a result of sample return to the Earth-Moon system. In view of the exploration plans before us, the NASA Solar System Exploration Program Roadmap published in May 2003 identified planetary protection as one of 13 technologies for "high priority technology investments." Recent discoveries at Mars and Jupiter, coupled with new policies, have made this planning for planetary protection technology particularly challenging and relevant.New missions to Mars have been formulated, which present significantly greater forward contamination potential. New policies, including the introduction by COSPAR of a Category IVc for planetary protection, have been adopted by COSPAR in response. Some missions may not be feasible without the introduction of new planetary protection technologies. Other missions may be technically possible but planetary protection requirements may be so costly to implement with current technology that they are not affordable. A strategic investment strategy will be needed to focus on technology investments designed to enable future missions and reduce the costs of future missions. This presentation will describe some of the potential technological pathways that may be most protective.

Exploration of Potential Future Fleet Architectures

DTIC Science & Technology

2005-07-01

alternative architectures are those espoused by the OFT sponsoring office: flexibility, adaptability, agility, speed, and information dominance through...including naval forces, which we used. The OFT advocates flexibility, adaptability, agility, speed, and information dominance through networking...challenges and transnational threats. In future conflicts, the Navy has plans to expand strike power, realize information dominance , and transform methods

Grand Challenges and Future Opportunities for Metal–Organic Frameworks

PubMed Central

2017-01-01

Metal–organic frameworks (MOFs) allow compositional and structural diversity beyond conventional solid-state materials. Continued interest in the field is justified by potential applications of exceptional breadth, ranging from gas storage and separation, which takes advantage of the inherent pores and their volume, to electronic applications, which requires precise control of electronic structure. In this Outlook we present some of the pertinent challenges that MOFs face in their conventional implementations, as well as opportunities in less traditional areas. Here the aim is to discuss select design concepts and future research goals that emphasize nuances relevant to this class of materials as a whole. Particular emphasis is placed on synthetic aspects, as they influence the potential for MOFs in gas separation, electrical conductivity, and catalytic applications. PMID:28691066

Grand Challenges and Future Opportunities for Metal–Organic Frameworks

DOE PAGES

Hendon, Christopher H.; Rieth, Adam J.; Korzyński, Maciej D.; ...

2017-06-06

Metal–organic frameworks (MOFs) allow compositional and structural diversity beyond conventional solid-state materials. Continued interest in the field is justified by potential applications of exceptional breadth, ranging from gas storage and separation, which takes advantage of the inherent pores and their volume, to electronic applications, which requires precise control of electronic structure. In this Outlook we present some of the pertinent challenges that MOFs face in their conventional implementations, as well as opportunities in less traditional areas. Here the aim is to discuss select design concepts and future research goals that emphasize nuances relevant to this class of materials as amore » whole. Particular emphasis is placed on synthetic aspects, as they influence the potential for MOFs in gas separation, electrical conductivity, and catalytic applications.« less

Telerehabilitation robotics: bright lights, big future?

PubMed

Carignan, Craig R; Krebs, Hermano I

2006-01-01

The potential for remote diagnosis and treatment over the Internet using robotics is now a reality. The state of the art is exemplified by several Internet applications, and we explore the current trends in developing new systems. We review the technical challenges that lie ahead, along with some potential solutions. Some promising results for a new bilateral system involving two InMotion2 robots are presented. Finally, we discuss the future direction and commercial outlook for rehabilitation robots over the next 15 years.

Regenerative Chemical Biology: Current Challenges and Future Potential

PubMed Central

Ao, Ada; Hao, Jijun; Hong, Charles C.

2011-01-01

The enthusiasm surrounding the clinical potential of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) is tempered by the fact that key issues regarding their safety, efficacy, and long-term benefits have thus far been suboptimal. Small molecules can potentially relieve these problems at major junctions of stem cell biology and regenerative therapy. In this review, we will introduce recent advances in these important areas and the first-generation of small molecules used in the regenerative context. Current chemical biology studies will provide the archetype for future interdisciplinary collaborations, and improve clinical benefits of cell-based therapies. PMID:21513877

Challenges faced by multidisplinary new investigators on addressing grand challenges in global health.

PubMed

Logie, Carmen; Dimaras, Helen; Fortin, Anny; Ramón-García, Santiago

2014-04-15

The grand challenges approach aims to spark innovative and transformative strategies to overcome barriers to significant global health issues. Grand Challenges Canada endorses an 'Integrated Innovation™' approach that focuses on the intersection of scientific/technological, social and business innovation. In this article we explore themes emerging from a dialogue between the authors, who are multidisciplinary recipients of the 'Rising Stars in Global Health' award from Grand Challenges Canada, regarding benefits of engaging in integrated innovation research, and recommendations for how this approach may develop in the future. Our dialogue followed a semi-structured interview format that addressed three topics: 1) reflections on applying an Integrated Innovation™ approach for global health; 2) thoughts on participation in the Grand Challenges 2012 meeting; and 3) authors' visions of Grand Challenges Canada and the Grand Challenge movement towards 2020. The dialogue was transcribed verbatim and we used thematic analysis techniques to identify, analyze and report themes in the data. Benefits of working using the Grand Challenges approach centered on two themes: a) the potential for scientific breakthrough and b) building interdisciplinary collaborations and a community of scholars. Challenges and opportunities for Grand Challenges in moving forward included: a) capacity building, particularly regarding Integrated Innovation™ and scale-up planning; b) interdisciplinary and international mentorship for new investigators; and c) potential for future commercialization. Our discussion highlighted that Integrated Innovation™ offers the opportunity to develop new theories, methods and approaches to global health while simultaneously fostering a collaborative spirit grounded in international, interdisciplinary collaborations. However, the arguable over-emphasis on corporatization poses a major challenge for new investigators. We propose a more balanced way forward that can harness technology to foster mentorship across time and space to support the development of such skills and ideas among new investigators.

Anti-infective use in children and pregnancy: current deficiencies and future challenges

PubMed Central

Gwee, Amanda; Cranswick, Noel

2015-01-01

There are a number of challenges to using anti-infective agents in children and pregnant women. There is limited understanding of the altered pharmacokinetics of anti-infectives in these populations and as a result, optimized dosing regimens are yet to be established. The potential adverse effects of the drug on pregnancy outcome and the developing foetus is a major consideration, and the long term implications of drug side effects must be taken into account when drug exposure occurs early in life. These factors hinder research and licensing of new anti-infective drugs in these populations. We describe the current deficiencies and future challenges of anti-infective use in children and pregnant women, providing specific examples. PMID:24588467

Sustainability assessment framework for scenarios – SAFS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arushanyan, Yevgeniya, E-mail: yevgeniya.arushanyan@abe.kth.se; KTH Royal Institute of Technology, Centre for Sustainable Communications; Ekener, Elisabeth

To address current challenges regarding sustainable development and support planning for this form of development, new learning about different possible futures and their potential sustainability implications is needed. One way of facilitating this learning is by combining the futures studies and sustainability assessment (SA) research fields. This paper presents the sustainability assessment framework for scenarios (SAFS), a method developed for assessing the environmental and social risks and opportunities of future scenarios, provides guidelines for its application and demonstrates how the framework can be applied. SAFS suggests assessing environmental and social aspects using a consumption perspective and a life cycle approach,more » and provides qualitative results. SAFS does not suggest any modelling using precise data, but instead offers guidelines on how to carry out a qualitative assessment, where both the process of assessing and the outcome of the assessment are valuable and can be used as a basis for discussion. The benefits, drawbacks and potential challenges of applying SAFS are also discussed in the paper. SAFS uses systems thinking looking at future societies as a whole, considering both environmental and social consequences. This encourages researchers and decision-makers to consider the whole picture, and not just individual elements, when considering different futures. - Highlights: • The paper presents a new methodological framework for qualitative sustainability assessment of future scenarios with transformative changes. • The framework suggests qualitative assessment with consumption perspective and a life cycle approach. • The paper presents the framework and provides guidelines for its application. • The paper demonstrates on an example how the framework can be applied. • The benefits, drawbacks and challenges of the framework application and the need for further development are discussed.« less

Safety of disease-modifying drugs for multiple sclerosis in pregnancy: current challenges and future considerations for effective pharmacovigilance.

PubMed

Lu, Ellen; Wang, Bing Wei; Guimond, Colleen; Synnes, Anne; Sadovnick, A Dessa; Dahlgren, Leanne; Traboulsee, Anthony; Tremlett, Helen

2013-03-01

When contemplating a pregnancy, women treated for multiple sclerosis (MS) with a disease-modifying drug must decide to discontinue their medication before conception or risk exposing their unborn child to potential drug toxicity. Few studies exist as reference for patients and physicians, and of those available, the majority are less than ideal due to real-world constraints, ethical issues and methodological shortcomings. The authors provide a brief summary of existing animal and human data with current recommendations regarding the safety of IFN-β, glatiramer acetate, natalizumab, mitoxantrone, fingolimod and teriflunomide during pregnancy and lactation in women with MS. We also assess the quality, strengths and limitations of the existing studies including challenges with study design. The investigation of outcomes such as spontaneous abortion and congenital anomalies are highlighted with potential methodological improvements for future studies on drug safety in pregnancy suggested. The authors explore the pharmacokinetics and pharmacodynamics of the MS disease-modifying drugs for their possible mechanistic role in fetal harm and discuss the potential role of clinical trials. Future pharmacovigilance studies should continue to pursue multicenter collaboration with an emphasis on appropriate study design.

Educational Support for Orphans and Vulnerable Children in Primary Schools: Challenges and Interventions

ERIC Educational Resources Information Center

Mwoma, Teresa; Pillay, Jace

2016-01-01

Educational status is an important indicator of children's wellbeing and future life opportunities. It can predict growth potential and economic viability of a state. While this is an ideal situation for all children, the case may be different for orphans and vulnerable children (OVC) due to the challenges they go through on a daily basis. This…

Saving the Planet, Stretching Their Skills: Using Environmental Science Investigations to Challenge Gifted Children

ERIC Educational Resources Information Center

Schroth, Stephen T.

2018-01-01

Gifted children are often highly sensitive to their surroundings and are able to readily identify potential solutions to challenges that imperil the environment in which they live. Many gifted children are strong advocates of sustainable living, caring deeply about the world around them and its health in the future. For this reason, parents and…

Climate change challenges for central banks and financial regulators

NASA Astrophysics Data System (ADS)

Campiglio, Emanuele; Dafermos, Yannis; Monnin, Pierre; Ryan-Collins, Josh; Schotten, Guido; Tanaka, Misa

2018-06-01

The academic and policy debate regarding the role of central banks and financial regulators in addressing climate-related financial risks has rapidly expanded in recent years. This Perspective presents the key controversies and discusses potential research and policy avenues for the future. Developing a comprehensive analytical framework to assess the potential impact of climate change and the low-carbon transition on financial stability seems to be the first crucial challenge. These enhanced risk measures could then be incorporated in setting financial regulations and implementing the policies of central banks.

The potential biomarkers of drug addiction: proteomic and metabolomics challenges.

PubMed

Wang, Lv; Wu, Ning; Zhao, Tai-Yun; Li, Jin

2016-07-28

Drug addiction places a significant burden on society and individuals. Proteomics and metabolomics approaches pave the road for searching potential biomarkers to assist the diagnosis and treatment. This review summarized putative drug addiction-related biomarkers in proteomics and metabolomics studies and discussed challenges and prospects in future studies. Alterations of several hundred proteins and metabolites were reported when exposure to abused drug, which enriched in energy metabolism, oxidative stress response, protein modification and degradation, synaptic function and neurotrasmission, etc. Hsp70, peroxiredoxin-6 and α- and β-synuclein, as well as n-methylserotonin and purine metabolites, were promising as potential biomarker for drug addiction.

High Potentials: A CEO Perspective

ERIC Educational Resources Information Center

Hermans, Jeanine

2007-01-01

Finding high potentials has been identified as one of the major challenges for society and for higher education. But how does one find the talented individuals who will design the future of society? Can and should universities cooperate or compete with business and industry for these talents? Three CEOs reflect on this worldwide competition for…

A Priority-Based View of Future Challenges in International Nuclear Safeguards.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Matteucci, Kayla

The international nuclear safeguards community is faced with a host of challenges in the coming years, many of which have been outlined but have not been described in terms of their urgency. Literature regarding safeguards challenges is either broad and devoid of any reference to prioritization or tailored to a specific problem and removed from the overall goals of the safeguards community. For example, developing new methods of environmental sampling, improving containment and surveillance (C/S) technologies to increase efficiency and decrease inspection time, advancing nuclear material accountancy (NMA) techniques, and planning safeguards approaches for new types of nuclear facilities aremore » all important. They have not, however, been distinctly prioritized at a high level within the safeguards community. Based on a review of existing literature and interviews with experts on these upcoming challenges, this paper offers a high-level summary of present and future priorities in safeguards, with attention both to what is feasible and to what is most imperative. In doing so, the paper addresses the potential repercussions for failing to prioritize, with a focus on the risk of diversion of nuclear material. Within the context of shifts in the American political landscape, and keeping in mind that nonproliferation issues may take a backseat to others in the near future, a prioritized view of safeguards objectives will be vital. In the interest of expanding upon this work, the paper offers several potential conceptual models for prioritization which can be explored in greater depth upon further research.« less

Earth Observing System (EOS) Aqua and Aura Space Weather Effects on Operational Collision Avoidance

NASA Technical Reports Server (NTRS)

Guit, Bill

2017-01-01

This presentation will describe recent EOS Aqua and Aura operational collision avoidance experience during periods of solar and geomagnetic storm activity. It will highlight challenges faced by the operations team during short-notice, high-risk predicted close approaches. The presentation will highlight the evolution of the operational collision avoidance process for the EOS Aqua and Aura missions. The presentation will highlight operational challenges that have occurred, process improvements that have been implemented and identify potential future challenges.

Gaudi Evolution for Future Challenges

NASA Astrophysics Data System (ADS)

Clemencic, M.; Hegner, B.; Leggett, C.

2017-10-01

The LHCb Software Framework Gaudi was initially designed and developed almost twenty years ago, when computing was very different from today. It has also been used by a variety of other experiments, including ATLAS, Daya Bay, GLAST, HARP, LZ, and MINERVA. Although it has been always actively developed all these years, stability and backward compatibility have been favoured, reducing the possibilities of adopting new techniques, like multithreaded processing. R&D efforts like GaudiHive have however shown its potential to cope with the new challenges. In view of the LHC second Long Shutdown approaching and to prepare for the computing challenges for the Upgrade of the collider and the detectors, now is a perfect moment to review the design of Gaudi and plan future developments of the project. To do this LHCb, ATLAS and the Future Circular Collider community joined efforts to bring Gaudi forward and prepare it for the upcoming needs of the experiments. We present here how Gaudi will evolve in the next years and the long term development plans.

Pathology resident and fellow education in a time of disruptive technologies.

PubMed

Ziai, James M; Smith, Brian R

2012-12-01

The development of disruptive technologies is changing the practice of pathology. Their implementation challenges traditional educational paradigms. Training programs must adapt to these heuristic needs. The dual explosion of new medical knowledge and innovative methodologies adds new practice aspects to the pathologist's areas of expertise. This transformation potentially challenges the traditional core model of training. It raises questions as to how pathology should incorporate future expanding subspecialty needs into educational and practice models. This article examines the impact of these disruptive technologies on resident and fellow education and explores alternative educational and practice models that may better accommodate pathology's future. Copyright © 2012 Elsevier Inc. All rights reserved.

Homodyne Phase-Shift-Keying Systems: Past Challenges and Future Opportunities

NASA Astrophysics Data System (ADS)

Kazovsky, Leonid G.; Kalogerakis, Georgios; Shaw, Wei-Tao

2006-12-01

Homodyne phase-shift-keying systems can achieve the best receiver sensitivity and the longest transmission distance among all optical communication systems. This paper reviews recent research efforts in the field and examines future possibilities that might lead toward potential practical use of these systems. Additionally, phase estimation techniques based on feed-forward phase recovery and digital delay-lock loop approaches are examined, simulated, and compared.

Potential future land use threats to California's protected areas

USGS Publications Warehouse

Wilson, Tamara Sue; Sleeter, Benjamin Michael; Davis, Adam Wilkinson

2015-01-01

Increasing pressures from land use coupled with future changes in climate will present unique challenges for California’s protected areas. We assessed the potential for future land use conversion on land surrounding existing protected areas in California’s twelve ecoregions, utilizing annual, spatially explicit (250 m) scenario projections of land use for 2006–2100 based on the Intergovernmental Panel on Climate Change Special Report on Emission Scenarios to examine future changes in development, agriculture, and logging. We calculated a conversion threat index (CTI) for each unprotected pixel, combining land use conversion potential with proximity to protected area boundaries, in order to identify ecoregions and protected areas at greatest potential risk of proximal land conversion. Our results indicate that California’s Coast Range ecoregion had the highest CTI with competition for extractive logging placing the greatest demand on land in close proximity to existing protected areas. For more permanent land use conversions into agriculture and developed uses, our CTI results indicate that protected areas in the Central California Valley and Oak Woodlands are most vulnerable. Overall, the Eastern Cascades, Central California Valley, and Oak Woodlands ecoregions had the lowest areal percent of protected lands and highest conversion threat values. With limited resources and time, rapid, landscape-level analysis of potential land use threats can help quickly identify areas with higher conversion probability of future land use and potential changes to both habitat and potential ecosystem reserves. Given the broad range of future uncertainties, LULC projections are a useful tool allowing land managers to visualize alternative landscape futures, improve planning, and optimize management practices.

Planning and Conducting Research Activities.

ERIC Educational Resources Information Center

Christiansen, Richard L.

1983-01-01

Some directions and influences on dental research activities in the near future are discussed. Current challenges include international competition, fellowships, and equipment. Potential research activity includes preventive medicine, epidemiology, chronic illness, the elderly, bioengineering, materials research, nutrition, soft tissue research,…

Argonne OutLoud presents: The Solar Energy Challenge

ScienceCinema

Darling, Seth

2018-02-19

To better understand the current and future role of solar energy, Argonne's Seth Darling framed the global energy supply and demand outlook over the next 40 years while examining potential energy sources from a feasibility and sustainability perspective. He also discussed the promise and challenges of solar energy while providing a broad overview of related research taking place at Argonne as well as his group's work on organic solar cells.

Argonne OutLoud presents: The Solar Energy Challenge

DOE Office of Scientific and Technical Information (OSTI.GOV)

Darling, Seth

To better understand the current and future role of solar energy, Argonne's Seth Darling framed the global energy supply and demand outlook over the next 40 years while examining potential energy sources from a feasibility and sustainability perspective. He also discussed the promise and challenges of solar energy while providing a broad overview of related research taking place at Argonne as well as his group's work on organic solar cells.

Challenges faced by multidisplinary new investigators on addressing grand challenges in global health

PubMed Central

2014-01-01

Background The grand challenges approach aims to spark innovative and transformative strategies to overcome barriers to significant global health issues. Grand Challenges Canada endorses an ‘Integrated Innovation™’ approach that focuses on the intersection of scientific/technological, social and business innovation. In this article we explore themes emerging from a dialogue between the authors, who are multidisciplinary recipients of the ‘Rising Stars in Global Health’ award from Grand Challenges Canada, regarding benefits of engaging in integrated innovation research, and recommendations for how this approach may develop in the future. Discussion Our dialogue followed a semi-structured interview format that addressed three topics: 1) reflections on applying an Integrated Innovation™ approach for global health; 2) thoughts on participation in the Grand Challenges 2012 meeting; and 3) authors’ visions of Grand Challenges Canada and the Grand Challenge movement towards 2020. The dialogue was transcribed verbatim and we used thematic analysis techniques to identify, analyze and report themes in the data. Benefits of working using the Grand Challenges approach centered on two themes: a) the potential for scientific breakthrough and b) building interdisciplinary collaborations and a community of scholars. Challenges and opportunities for Grand Challenges in moving forward included: a) capacity building, particularly regarding Integrated Innovation™ and scale-up planning; b) interdisciplinary and international mentorship for new investigators; and c) potential for future commercialization. Conclusions Our discussion highlighted that Integrated Innovation™ offers the opportunity to develop new theories, methods and approaches to global health while simultaneously fostering a collaborative spirit grounded in international, interdisciplinary collaborations. However, the arguable over-emphasis on corporatization poses a major challenge for new investigators. We propose a more balanced way forward that can harness technology to foster mentorship across time and space to support the development of such skills and ideas among new investigators. PMID:24735677

Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine

PubMed Central

Rongvaux, Anthony; Takizawa, Hitoshi; Strowig, Till; Willinger, Tim; Eynon, Elizabeth E.

2014-01-01

To directly study complex human hemato-lymphoid system physiology and respective system-associated diseases in vivo, human-to-mouse xenotransplantation models for human blood and blood-forming cells and organs have been developed over the past three decades. We here review the fundamental requirements and the remarkable progress made over the past few years in improving these systems, the current major achievements reached by use of these models, and the future challenges to more closely model and study human health and disease and to achieve predictive preclinical testing of both prevention measures and potential new therapies. PMID:23330956

Intrauterine devices: learning from the past and looking to the future.

PubMed

Petta, C A; McPheeters, M; Chi, I C

1996-04-01

This paper reviews the historical development of the IUD, describing the challenges and successes, and attempts to offer a balanced perspective for family planning service workers today. Modern IUDs are an important component of family planning services and an excellent contraceptive choice for properly screened women, providing contraception that is safe, effective, long lasting and cost effective. Potential research strategies for the future are also discussed.

Implementation of a teaching assistant program in graduate nursing education.

PubMed

Goode, Victoria M; Horvath, Catherine; Jasinski, Donna

2013-01-01

Identifying and educating students who have an interest and talent to be future educators is a challenge throughout academia, including nursing. The ideal scenario is to identify students early in their education and construct or scaffold a unique relationship between professor and student. The authors discuss a teaching assistant model, implemented in a nursing graduate program, which augments the education process while developing potential future nursing educators.

Potential and prospective implementation of carbon nanotubes on next generation aircraft and space vehicles: A review of current and expected applications in aerospace sciences

NASA Astrophysics Data System (ADS)

Gohardani, Omid; Elola, Maialen Chapartegui; Elizetxea, Cristina

2014-10-01

Carbon nanotubes have instigated the interest of many different scientific fields since their authenticated introduction, more than two decades ago. Particularly in aerospace applications, the potential implementations of these advanced materials have been predicted to have a large impact on future aircraft and space vehicles, mainly due to their distinct features, which include superior mechanical, thermal and electrical properties. This article provides the very first consolidated review of the imminent prospects of utilizing carbon nanotubes and nanoparticles in aerospace sciences, based on their recent implementations and predicted future applications. Explicitly, expected carbon nanotube employment in aeronautics and astronautics are identified for commercial aircraft, military aircraft, rotorcraft, unmanned aerial vehicles, satellites, and space launch vehicles. Attention is devoted to future utilization of carbon nanotubes, which may comprise hydrogen storage encapsulation, composite material implementation, lightning protection for aircraft, aircraft icing mitigation, reduced weight of airframes/satellites, and alleviation of challenges related to future space launch. This study further sheds light onto recent actualized implementations of carbon nanotubes in aerospace applications, as well as current and prospective challenges related to their usage in aerospace sciences, encompassing health and safety hazards, large scale manufacturing, achievement of optimum properties, recycling, and environmental impacts.

Renewable Electricity Futures Study. Volume 1: Exploration of High-Penetration Renewable Electricity Futures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mai, T.; Wiser, R.; Sandor, D.

2012-06-01

The Renewable Electricity Futures (RE Futures) Study investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050. The analysis focused on the sufficiency of the geographically diverse U.S. renewable resources to meet electricity demand over future decades, the hourly operational characteristics of the U.S. grid with high levels of variable wind and solar generation, and the potential implications of deploying high levels of renewables in the future. RE Futures focused on technical aspects of high penetration of renewable electricity; it did not focus on how to achieve such a futuremore » through policy or other measures. Given the inherent uncertainties involved with analyzing alternative long-term energy futures as well as the multiple pathways that might be taken to achieve higher levels of renewable electricity supply, RE Futures explored a range of scenarios to investigate and compare the impacts of renewable electricity penetration levels (30%-90%), future technology performance improvements, potential constraints to renewable electricity development, and future electricity demand growth assumptions. RE Futures was led by the National Renewable Energy Laboratory (NREL) and the Massachusetts Institute of Technology (MIT).« less

Designing PISA-Like Mathematics Tasks In Indonesia: Experiences and Challenges

NASA Astrophysics Data System (ADS)

Zulkardi, Z.; Kohar, A. W.

2018-01-01

The insignificant improvement of Indonesian students in PISA mathematics survey triggered researchers in Indonesia to develop PISA-like mathematics tasks. Some development studies have been conducted to produce valid and practical PISA-like problems that potentially effect on improving students’ mathematical literacy. This article describes the experiences of Indonesian task designers in developing PISA-like mathematics tasks as well as the potential future studies regarding to mathematical literacy as challenges for policy makers, researchers, and practitioners to improve students’ mathematical literacy in Indonesia. The results of this research indicate the task designers to consider domains of PISA like: context, mathematical content, and process as the first profiles of their missions. Our analysis shows that the designers mostly experienced difficulties regarding to the authenticity of context use and language structure. Interestingly, many of them used a variety of local wisdom in Indonesia as contexts for designing PISA-like tasks. In addition, the products developed were reported to be potentially effects on students’ interest and elicit students’ mathematical competencies as mentioned in PISA framework. Finally, this paper discusses future studies such as issues in bringing PISA task into an instructional practice.

Educating toward the Future.

ERIC Educational Resources Information Center

Gallin, Alice, Ed.; Gallagher, Paul J., Ed.

1989-01-01

The following articles are presented: (1) "Introduction"--background regarding the Catholic Church's response to the educational needs of the Hispanic population (Paul J. Gallagher); (2) "Hispanics and the Neylan Colleges: The Potential and the Challenge" (Jane Forni); (3) "Minority Recruitment: Good Sense, Not Good…

Learning through Making and Maker Education

ERIC Educational Resources Information Center

Hsu, Yu-Chang; Baldwin, Sally; Ching, Yu-Hui

2017-01-01

In this paper, we provide an overview of the current efforts in maker education, supported by a review of empirical studies. Our synthesis will inform the community about learning outcomes, potential and common issues, challenges, resources, and future research direction regarding maker education.

Long-Term Preservation of NASA Heliophysics Data and Access: Where We Were and Where We're Going

NASA Technical Reports Server (NTRS)

McGuire, Robert E.

2011-01-01

The importance of ensuring preservation and useful access to the unique science potential of past, present and future NASA solar and space physics (i.e. heliophysics) data has been recognized since the inception of NASA but remains challenging. In this talk, I will briefly review the history of this topic and and then discuss the present NASA model for heliophysics science data management, including key current resources for finding and using data projects like the Space Physics Data Facility. I will highlight expected future directions, building on working elements of the present program and exploiting new technology, to further improve the data environment, address existing issues and anticipate emerging challenges.

Killer Apps: Developing Novel Applications That Enhance Team Coordination, Communication, and Effectiveness

PubMed Central

Buengeler, Claudia; Klonek, Florian; Lehmann-Willenbrock, Nale; Morency, Louis-Philippe; Poppe, Ronald

2017-01-01

As part of the Lorentz workshop, “Interdisciplinary Insights into Group and Team Dynamics,” held in Leiden, Netherlands, this article describes how Geeks and Groupies (computer and social scientists) may benefit from interdisciplinary collaboration toward the development of killer apps in team contexts that are meaningful and challenging for both. First, we discuss interaction processes during team meetings as a research topic for both Groupies and Geeks. Second, we highlight teamwork in health care settings as an interdisciplinary research challenge. Third, we discuss how an automated solution for optimal team design could benefit team effectiveness and feed into team-based interventions. Fourth, we discuss team collaboration in massive open online courses as a challenge for both Geeks and Groupies. We argue for the necessary integration of social and computational research insights and approaches. In the hope of inspiring future interdisciplinary collaborations, we develop criteria for evaluating killer apps—including the four proposed here—and discuss future research challenges and opportunities that potentially derive from these developments. PMID:28989264

Killer Apps: Developing Novel Applications That Enhance Team Coordination, Communication, and Effectiveness.

PubMed

Buengeler, Claudia; Klonek, Florian; Lehmann-Willenbrock, Nale; Morency, Louis-Philippe; Poppe, Ronald

2017-10-01

As part of the Lorentz workshop, "Interdisciplinary Insights into Group and Team Dynamics," held in Leiden, Netherlands, this article describes how Geeks and Groupies (computer and social scientists) may benefit from interdisciplinary collaboration toward the development of killer apps in team contexts that are meaningful and challenging for both. First, we discuss interaction processes during team meetings as a research topic for both Groupies and Geeks. Second, we highlight teamwork in health care settings as an interdisciplinary research challenge. Third, we discuss how an automated solution for optimal team design could benefit team effectiveness and feed into team-based interventions. Fourth, we discuss team collaboration in massive open online courses as a challenge for both Geeks and Groupies. We argue for the necessary integration of social and computational research insights and approaches. In the hope of inspiring future interdisciplinary collaborations, we develop criteria for evaluating killer apps-including the four proposed here-and discuss future research challenges and opportunities that potentially derive from these developments.

Challenges for semilocal density functionals with asymptotically nonvanishing potentials

NASA Astrophysics Data System (ADS)

Aschebrock, Thilo; Armiento, Rickard; Kümmel, Stephan

2017-08-01

The Becke-Johnson model potential [A. D. Becke and E. R. Johnson, J. Chem. Phys. 124, 221101 (2006), 10.1063/1.2213970] and the potential of the AK13 functional [R. Armiento and S. Kümmel, Phys. Rev. Lett. 111, 036402 (2013), 10.1103/PhysRevLett.111.036402] have been shown to mimic features of the exact Kohn-Sham exchange potential, such as step structures that are associated with shell closings and particle-number changes. A key element in the construction of these functionals is that the potential has a limiting value far outside a finite system that is a system-dependent constant rather than zero. We discuss a set of anomalous features in these functionals that are closely connected to the nonvanishing asymptotic potential. The findings constitute a formidable challenge for the future development of semilocal functionals based on the concept of a nonvanishing asymptotic constant.

Renewable Electricity Futures Study. Volume 4: Bulk Electric Power Systems: Operations and Transmission Planning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Milligan, M.; Ela, E.; Hein, J.

2012-06-01

The Renewable Electricity Futures (RE Futures) Study investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050. The analysis focused on the sufficiency of the geographically diverse U.S. renewable resources to meet electricity demand over future decades, the hourly operational characteristics of the U.S. grid with high levels of variable wind and solar generation, and the potential implications of deploying high levels of renewables in the future. RE Futures focused on technical aspects of high penetration of renewable electricity; it did not focus on how to achieve such a futuremore » through policy or other measures. Given the inherent uncertainties involved with analyzing alternative long-term energy futures as well as the multiple pathways that might be taken to achieve higher levels of renewable electricity supply, RE Futures explored a range of scenarios to investigate and compare the impacts of renewable electricity penetration levels (30%-90%), future technology performance improvements, potential constraints to renewable electricity development, and future electricity demand growth assumptions. RE Futures was led by the National Renewable Energy Laboratory (NREL) and the Massachusetts Institute of Technology (MIT).« less

Renewable Electricity Futures Study. Volume 3: End-Use Electricity Demand

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hostick, D.; Belzer, D.B.; Hadley, S.W.

2012-06-01

The Renewable Electricity Futures (RE Futures) Study investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050. The analysis focused on the sufficiency of the geographically diverse U.S. renewable resources to meet electricity demand over future decades, the hourly operational characteristics of the U.S. grid with high levels of variable wind and solar generation, and the potential implications of deploying high levels of renewables in the future. RE Futures focused on technical aspects of high penetration of renewable electricity; it did not focus on how to achieve such a futuremore » through policy or other measures. Given the inherent uncertainties involved with analyzing alternative long-term energy futures as well as the multiple pathways that might be taken to achieve higher levels of renewable electricity supply, RE Futures explored a range of scenarios to investigate and compare the impacts of renewable electricity penetration levels (30%-90%), future technology performance improvements, potential constraints to renewable electricity development, and future electricity demand growth assumptions. RE Futures was led by the National Renewable Energy Laboratory (NREL) and the Massachusetts Institute of Technology (MIT).« less

Renewable Electricity Futures Study. Volume 2: Renewable Electricity Generation and Storage Technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Augustine, C.; Bain, R.; Chapman, J.

2012-06-01

The Renewable Electricity Futures (RE Futures) Study investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050. The analysis focused on the sufficiency of the geographically diverse U.S. renewable resources to meet electricity demand over future decades, the hourly operational characteristics of the U.S. grid with high levels of variable wind and solar generation, and the potential implications of deploying high levels of renewables in the future. RE Futures focused on technical aspects of high penetration of renewable electricity; it did not focus on how to achieve such a futuremore » through policy or other measures. Given the inherent uncertainties involved with analyzing alternative long-term energy futures as well as the multiple pathways that might be taken to achieve higher levels of renewable electricity supply, RE Futures explored a range of scenarios to investigate and compare the impacts of renewable electricity penetration levels (30%-90%), future technology performance improvements, potential constraints to renewable electricity development, and future electricity demand growth assumptions. RE Futures was led by the National Renewable Energy Laboratory (NREL) and the Massachusetts Institute of Technology (MIT).« less

Renewable Electricity Futures Study. Executive Summary

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mai, T.; Sandor, D.; Wiser, R.

2012-12-01

The Renewable Electricity Futures (RE Futures) Study investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050. The analysis focused on the sufficiency of the geographically diverse U.S. renewable resources to meet electricity demand over future decades, the hourly operational characteristics of the U.S. grid with high levels of variable wind and solar generation, and the potential implications of deploying high levels of renewables in the future. RE Futures focused on technical aspects of high penetration of renewable electricity; it did not focus on how to achieve such a futuremore » through policy or other measures. Given the inherent uncertainties involved with analyzing alternative long-term energy futures as well as the multiple pathways that might be taken to achieve higher levels of renewable electricity supply, RE Futures explored a range of scenarios to investigate and compare the impacts of renewable electricity penetration levels (30%-90%), future technology performance improvements, potential constraints to renewable electricity development, and future electricity demand growth assumptions. RE Futures was led by the National Renewable Energy Laboratory (NREL) and the Massachusetts Institute of Technology (MIT).« less

The effect of challenge and threat states on performance: An examination of potential mechanisms

PubMed Central

Moore, Lee J; Vine, Samuel J; Wilson, Mark R; Freeman, Paul

2012-01-01

Challenge and threat states predict future performance; however, no research has examined their immediate effect on motor task performance. The present study examined the effect of challenge and threat states on golf putting performance and several possible mechanisms. One hundred twenty-seven participants were assigned to a challenge or threat group and performed six putts during which emotions, gaze, putting kinematics, muscle activity, and performance were recorded. Challenge and threat states were successively manipulated via task instructions. The challenge group performed more accurately, reported more favorable emotions, and displayed more effective gaze, putting kinematics, and muscle activity than the threat group. Multiple putting kinematic variables mediated the relationship between group and performance, suggesting that challenge and threat states impact performance at a predominately kinematic level. PMID:22913339

Supportability Challenges, Metrics, and Key Decisions for Future Human Spaceflight

NASA Technical Reports Server (NTRS)

Owens, Andrew C.; de Weck, Olivier L.; Stromgren, Chel; Cirillo, William; Goodliff, Kandyce

2017-01-01

Future crewed missions beyond Low Earth Orbit (LEO) represent a logistical challenge that is unprecedented in human space flight. Astronauts will travel farther and stay in space for longer than any previous mission, far from timely abort or resupply from Earth. Under these conditions, supportability { defined as the set of system characteristics that influence the logistics and support required to enable safe and effective operations of systems { will be a much more significant driver of space system lifecycle properties than it has been in the past. This paper presents an overview of supportability for future human space flight. The particular challenges of future missions are discussed, with the differences between past, present, and future missions highlighted. The relationship between supportability metrics and mission cost, performance, schedule, and risk is also discussed. A set of pro- posed strategies for managing supportability is presented (including reliability growth, uncertainty reduction, level of repair, commonality, redundancy, In-Space Manufacturing (ISM) (including the use of material recycling and In-Situ Resource Utilization (ISRU) for spares and maintenance items), reduced complexity, and spares inventory decisions such as the use of predeployed or cached spares - along with a discussion of the potential impacts of each of those strategies. References are provided to various sources that describe these supportability metrics and strategies, as well as associated modeling and optimization techniques, in greater detail. Overall, supportability is an emergent system characteristic and a holistic challenge for future system development. System designers and mission planners must carefully consider and balance the supportability metrics and decisions described in this paper in order to enable safe and effective beyond-LEO human space flight.

3D and 4D Bioprinting of the Myocardium: Current Approaches, Challenges, and Future Prospects

PubMed Central

Ong, Chin Siang; Nam, Lucy; Ong, Kingsfield; Krishnan, Aravind; Huang, Chen Yu; Fukunishi, Takuma

2018-01-01

3D and 4D bioprinting of the heart are exciting notions in the modern era. However, myocardial bioprinting has proven to be challenging. This review outlines the methods, materials, cell types, issues, challenges, and future prospects in myocardial bioprinting. Advances in 3D bioprinting technology have significantly improved the manufacturing process. While scaffolds have traditionally been utilized, 3D bioprinters, which do not require scaffolds, are increasingly being employed. Improved understanding of the cardiac cellular composition and multiple strategies to tackle the issues of vascularization and viability had led to progress in this field. In vivo studies utilizing small animal models have been promising. 4D bioprinting is a new concept that has potential to advance the field of 3D bioprinting further by incorporating the fourth dimension of time. Clinical translation will require multidisciplinary collaboration to tackle the pertinent issues facing this field. PMID:29850546

Renewable Electricity Futures Study. Volume 1. Exploration of High-Penetration Renewable Electricity Futures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hand, M. M.; Baldwin, S.; DeMeo, E.

2012-06-15

The Renewable Electricity Futures (RE Futures) Study investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050. The analysis focused on the sufficiency of the geographically diverse U.S. renewable resources to meet electricity demand over future decades, the hourly operational characteristics of the U.S. grid with high levels of variable wind and solar generation, and the potential implications of deploying high levels of renewables in the future. RE Futures focused on technical aspects of high penetration of renewable electricity; it did not focus on how to achieve such a futuremore » through policy or other measures. Given the inherent uncertainties involved with analyzing alternative long-term energy futures as well as the multiple pathways that might be taken to achieve higher levels of renewable electricity supply, RE Futures explored a range of scenarios to investigate and compare the impacts of renewable electricity penetration levels (30%–90%), future technology performance improvements, potential constraints to renewable electricity development, and future electricity demand growth assumptions. RE Futures was led by the National Renewable Energy Laboratory (NREL) and the Massachusetts Institute of Technology (MIT). Learn more at the RE Futures website. http://www.nrel.gov/analysis/re_futures/« less

Interdisciplinary science for future governance and management of forests.

PubMed

Nordin, Annika; Sandström, Camilla

2016-02-01

The sustainable use of forests constitutes one of the great challenges for the future due to forests' large spatial coverage, long-term planning horizons and inclusion of many ecosystem services. The mission of the Future Forests programme is to provide a scientifically robust knowledge base for sustainable governance and management of forests preparing for a future characterized by globalization and climate change. In this introduction to the Special Issue, we describe the interdisciplinary science approach developed in close collaboration with actors in the Future Forests programme, and discuss the potential impacts of this science on society. In addition, we introduce the 13 scientific articles and present results produced by the programme.

The potential for a new era of supersonic and hypersonic aviation

NASA Technical Reports Server (NTRS)

Harris, Roy V.

1990-01-01

A new era of supersonic and hypersonic aviation is envisioned. The potential for supersonic and hypersonic flight vehicles in this new era is analyzed. Technology challenges that must be met in order to bring in this new era of flight are discussed. The current technical status and future potential are cited in the areas of aerodynamics, propulsion, and structural materials. A next major step in the development of high-speed air transportation is suggested.

Renewable Electricity Futures Study. Volume 2. Renewable Electricity Generation and Storage Technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Augustine, Chad; Bain, Richard; Chapman, Jamie

2012-06-15

The Renewable Electricity Futures (RE Futures) Study investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050. The analysis focused on the sufficiency of the geographically diverse U.S. renewable resources to meet electricity demand over future decades, the hourly operational characteristics of the U.S. grid with high levels of variable wind and solar generation, and the potential implications of deploying high levels of renewables in the future. RE Futures focused on technical aspects of high penetration of renewable electricity; it did not focus on how to achieve such a futuremore » through policy or other measures. Given the inherent uncertainties involved with analyzing alternative long-term energy futures as well as the multiple pathways that might be taken to achieve higher levels of renewable electricity supply, RE Futures explored a range of scenarios to investigate and compare the impacts of renewable electricity penetration levels (30%–90%), future technology performance improvements, potential constraints to renewable electricity development, and future electricity demand growth assumptions. RE Futures was led by the National Renewable Energy Laboratory (NREL) and the Massachusetts Institute of Technology (MIT). Learn more at the RE Futures website. http://www.nrel.gov/analysis/re_futures/« less

Renewable Electricity Futures Study. Volume 3. End-Use Electricity Demand

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hostick, Donna; Belzer, David B.; Hadley, Stanton W.

2012-06-15

The Renewable Electricity Futures (RE Futures) Study investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050. The analysis focused on the sufficiency of the geographically diverse U.S. renewable resources to meet electricity demand over future decades, the hourly operational characteristics of the U.S. grid with high levels of variable wind and solar generation, and the potential implications of deploying high levels of renewables in the future. RE Futures focused on technical aspects of high penetration of renewable electricity; it did not focus on how to achieve such a futuremore » through policy or other measures. Given the inherent uncertainties involved with analyzing alternative long-term energy futures as well as the multiple pathways that might be taken to achieve higher levels of renewable electricity supply, RE Futures explored a range of scenarios to investigate and compare the impacts of renewable electricity penetration levels (30%–90%), future technology performance improvements, potential constraints to renewable electricity development, and future electricity demand growth assumptions. RE Futures was led by the National Renewable Energy Laboratory (NREL) and the Massachusetts Institute of Technology (MIT). Learn more at the RE Futures website. http://www.nrel.gov/analysis/re_futures/« less

Renewable Electricity Futures Study. Volume 4: Bulk Electric Power Systems. Operations and Transmission Planning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Milligan, Michael; Ela, Erik; Hein, Jeff

2012-06-15

The Renewable Electricity Futures (RE Futures) Study investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050. The analysis focused on the sufficiency of the geographically diverse U.S. renewable resources to meet electricity demand over future decades, the hourly operational characteristics of the U.S. grid with high levels of variable wind and solar generation, and the potential implications of deploying high levels of renewables in the future. RE Futures focused on technical aspects of high penetration of renewable electricity; it did not focus on how to achieve such a futuremore » through policy or other measures. Given the inherent uncertainties involved with analyzing alternative long-term energy futures as well as the multiple pathways that might be taken to achieve higher levels of renewable electricity supply, RE Futures explored a range of scenarios to investigate and compare the impacts of renewable electricity penetration levels (30%–90%), future technology performance improvements, potential constraints to renewable electricity development, and future electricity demand growth assumptions. RE Futures was led by the National Renewable Energy Laboratory (NREL) and the Massachusetts Institute of Technology (MIT). Learn more at the RE Futures website. http://www.nrel.gov/analysis/re_futures/« less

Anterior eye segment drug delivery systems: current treatments and future challenges.

PubMed

Molokhia, Sarah A; Thomas, Samuel C; Garff, Kevin J; Mandell, Kenneth J; Wirostko, Barbara M

2013-03-01

New technologies for delivery of drugs, such as small molecules and biologics, are of growing interest among clinical and pharmaceutical researchers for use in treating anterior segment eye disease. The challenge is to deliver effective drugs at therapeutic concentrations to the targeted ocular tissue with minimal side effects. To achieve this, a better understanding of the unmet needs, what is required of the various methods of delivery to achieve successful delivery, and the potential challenges of anterior segment drug delivery is necessary and the primarily aim of this review. This review covers the various physiological and anatomical barriers that exist for effective delivery to the targeted tissue of the eye, the pathological conditions of the anterior segment, and the unmet needs for treatment of these ocular diseases. Second, it reviews the novel delivery technologies that have the potential to maintain and/or improve the drug's therapeutic index and improving both patient adherence for chronic therapy and potential patient outcomes. This review bridges the pharmaceutical and clinical research/challenges and provides a detailed overview of anterior segment drug delivery accomplishments thus far, for researchers and clinicians.

"The Impossible" Future

ERIC Educational Resources Information Center

Higgins, Lee

2007-01-01

Providing genuine opportunities for musical engagement is a constant challenge for music educators. Throughout their working lives, they may find "authentic" moments of musical engagement ever harder to manifest. The potential obstacles are numerous: the size or configuration of physical space, the number of instruments available, the quality of…

Non-Renewal of Probationary Teachers: Negative Retention

ERIC Educational Resources Information Center

Nixon, Andy; Packard, Abbot; Douvanis, Gus

2010-01-01

For students, quality teaching means the difference between a bright or potentially dim future. School principals face several challenges that work against recommending contract non-renewal for incompetent teachers. This study investigates the reasons that school principals recommend contract non-renewal of probationary teachers. Targeted…

Novel Modeling Tools for Propagating Climate Change Variability and Uncertainty into Hydrodynamic Forecasts

EPA Science Inventory

Understanding impacts of climate change on hydrodynamic processes and ecosystem response within the Great Lakes is an important and challenging task. Variability in future climate conditions, uncertainty in rainfall-runoff model forecasts, the potential for land use change, and t...

Novel Flexible Wearable Sensor Materials and Signal Processing for Vital Sign and Human Activity Monitoring.

PubMed

Servati, Amir; Zou, Liang; Wang, Z Jane; Ko, Frank; Servati, Peyman

2017-07-13

Advances in flexible electronic materials and smart textile, along with broad availability of smart phones, cloud and wireless systems have empowered the wearable technologies for significant impact on future of digital and personalized healthcare as well as consumer electronics. However, challenges related to lack of accuracy, reliability, high power consumption, rigid or bulky form factor and difficulty in interpretation of data have limited their wide-scale application in these potential areas. As an important solution to these challenges, we present latest advances in novel flexible electronic materials and sensors that enable comfortable and conformable body interaction and potential for invisible integration within daily apparel. Advances in novel flexible materials and sensors are described for wearable monitoring of human vital signs including, body temperature, respiratory rate and heart rate, muscle movements and activity. We then present advances in signal processing focusing on motion and noise artifact removal, data mining and aspects of sensor fusion relevant to future clinical applications of wearable technology.

Novel Flexible Wearable Sensor Materials and Signal Processing for Vital Sign and Human Activity Monitoring

PubMed Central

Servati, Amir; Wang, Z. Jane; Ko, Frank; Servati, Peyman

2017-01-01

Advances in flexible electronic materials and smart textile, along with broad availability of smart phones, cloud and wireless systems have empowered the wearable technologies for significant impact on future of digital and personalized healthcare as well as consumer electronics. However, challenges related to lack of accuracy, reliability, high power consumption, rigid or bulky form factor and difficulty in interpretation of data have limited their wide-scale application in these potential areas. As an important solution to these challenges, we present latest advances in novel flexible electronic materials and sensors that enable comfortable and conformable body interaction and potential for invisible integration within daily apparel. Advances in novel flexible materials and sensors are described for wearable monitoring of human vital signs including, body temperature, respiratory rate and heart rate, muscle movements and activity. We then present advances in signal processing focusing on motion and noise artifact removal, data mining and aspects of sensor fusion relevant to future clinical applications of wearable technology. PMID:28703744

The future of type 1 cannabinoid receptor allosteric ligands.

PubMed

Alaverdashvili, Mariam; Laprairie, Robert B

2018-02-01

Allosteric modulation of the type 1 cannabinoid receptor (CB1R) holds great therapeutic potential. This is because allosteric modulators do not possess intrinsic efficacy, but instead augment (positive allosteric modulation) or diminish (negative allosteric modulation) the receptor's response to endogenous ligand. Consequently, CB1R allosteric modulators have an effect ceiling which allows for the tempering of CB1R signaling without the desensitization, tolerance, dependence, and psychoactivity associated with orthosteric compounds. Pain, movement disorders, epilepsy, obesity are all potential therapeutic targets for CB1R allosteric modulation. Several challenges exist for the development of CB1R allosteric modulators, such as receptor subtype specificity, translation to in vivo systems, and mixed allosteric/agonist/inverse agonist activity. Despite these challenges, elucidation of crystal structures of CB1R and compound design based on structure-activity relationships will advance the field. In this review, we will cover recent progress for CB1R allosteric modulators and discuss the future promise of this research.

An introduction to global carbon cycle management

USGS Publications Warehouse

Sundquist, Eric T.; Ackerman, Katherine V.; Parker, Lauren; Huntzinger, Deborah N.

2009-01-01

Past and current human activities have fundamentally altered the global carbon cycle. Potential future efforts to control atmospheric CO2 will also involve significant changes in the global carbon cycle. Carbon cycle scientists and engineers now face not only the difficulties of recording and understanding past and present changes but also the challenge of providing information and tools for new management strategies that are responsive to societal needs. The challenge is nothing less than managing the global carbon cycle.

Enhancing international collaboration among early career researchers.

PubMed

Carroll, Jennifer K; Albada, Akke; Farahani, Mansoureh; Lithner, Maria; Neumann, Melanie; Sandhu, Harbinder; Shepherd, Heather L

2010-09-01

The European Association of Communication in Healthcare (EACH) Early Career Researchers Network (ECRN) aims are to (1) promote international collaboration among young investigators and (2) provide a support network for future innovative communication research projects. In October 2009, Miami, USA at a workshop facilitated by the ECRN at the International Conference on Communication in Healthcare (ICCH) hosted by the American Academy of Communication in Healthcare we explored common facilitators and challenges faced by early career researchers in health communication research. Attendees introduced themselves, their research area(s) of interest, and listed one facilitator and one barrier for their career development. EACH ECRN members then led a discussion of facilitators and challenges encountered in communication research projects and career development. We discussed potential collaboration opportunities, future goals, and activities. Having supportive collegial relationships, institutional support, job security, and funding are critical facilitators for early career investigators. Key challenges include difficulty with time management and prioritizing, limited resources, and contacts. International collaboration among early career researchers is a feasible and effective means to address important challenges, by increasing opportunities for professional support and networking, problem-solving, discussion of data, and ultimately publishing. Future AACH-EACH Early Career Researcher Networks should continue to build collaborations by developing shared research projects, papers, and other scholarly products. Copyright (c) 2010. Published by Elsevier Ireland Ltd.

Enhancing international collaboration among early-career researchers

PubMed Central

Carroll, Jennifer K; Albada, Akke; Farahani, Mansoureh; Lithner, Maria; Neumann, Melanie; Sandhu, Harbinder; Shepherd, Heather L

2010-01-01

Objective The European Association of Communication in Healthcare (EACH) Early Career Researchers Network (ECRN) aims are to (1) promote international collaboration among young investigators and (2) provide a support network for future innovative communication research projects. In October 2009, Miami, USA at a workshop facilitated by the ECRN at the International Conference on Communication in Healthcare (ICCH) hosted by the American Academy of Communication in Healthcare we explored common facilitators and challenges faced by early career researchers in health communication research. Methods Attendees introduced themselves, their research area(s) of interest, and listed one facilitator and one barrier for their career development. EACH ECRN members then led a discussion of facilitators and challenges encountered in communication research projects and career development. We discussed potential collaboration opportunities, future goals, and activities. Results Having supportive collegial relationships, institutional support, job security, and funding are critical facilitators for early career investigators. Key challenges include difficulty with time management and prioritizing, limited resources, and contacts. Conclusion International collaboration among early career researchers is a feasible and effective means to address important challenges, by increasing opportunities for professional support and networking, problem-solving, discussion of data, and ultimately publishing. Practice Implications Future AACH-EACH Early Career Researcher Networks should continue to build collaborations by developing shared research projects, papers, and other scholarly products. PMID:20663630

TH-D-BRC-01: Panel Member

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aydogan, B.

Interest in proton therapy has increased dramatically in the past couple of years, especially in the United States. There certainly is an important place for proton therapy in the arsenal of cancer treatments. Its dosimetric advantage and potential for low toxicity makes it the perfect partner for photons and other cancer treatment modalities. Often there is a belief that the new technology ought to be better but many believe that they should be widely adopted in the clinic only after evidence has shown that they are at least as safe and efficacious as existing technologies, which are often less expensive.more » This is the case for proton radiotherapy. This session being both educational and debate will provide a good review of basics and technological advancement as well as a comprehensive clinical update for both proton and photon therapy. Future technology developments and how they will impact the potential dosimetric advantage of proton therapy will be discussed. Particularly the debate will focus on whether these developments will close or widen the gap between photon and proton therapy. Learning Objectives: To review challenges, limitations, and recent and future developments in proton therapy. To review challenges, limitations, recent and future developments in photon radiotherapy. To review current clinical trials and challenging clinical cases. C. Yu, No company or organization that my presentation mentions provided me with financial support. I am the Founder and CEO of Xcision Medical Systems, LLC. However, my presentation will not mention any product or technology developed by Xcision.« less

TH-D-BRC-02: Panel Member

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hahn, S.

Interest in proton therapy has increased dramatically in the past couple of years, especially in the United States. There certainly is an important place for proton therapy in the arsenal of cancer treatments. Its dosimetric advantage and potential for low toxicity makes it the perfect partner for photons and other cancer treatment modalities. Often there is a belief that the new technology ought to be better but many believe that they should be widely adopted in the clinic only after evidence has shown that they are at least as safe and efficacious as existing technologies, which are often less expensive.more » This is the case for proton radiotherapy. This session being both educational and debate will provide a good review of basics and technological advancement as well as a comprehensive clinical update for both proton and photon therapy. Future technology developments and how they will impact the potential dosimetric advantage of proton therapy will be discussed. Particularly the debate will focus on whether these developments will close or widen the gap between photon and proton therapy. Learning Objectives: To review challenges, limitations, and recent and future developments in proton therapy. To review challenges, limitations, recent and future developments in photon radiotherapy. To review current clinical trials and challenging clinical cases. C. Yu, No company or organization that my presentation mentions provided me with financial support. I am the Founder and CEO of Xcision Medical Systems, LLC. However, my presentation will not mention any product or technology developed by Xcision.« less

TH-D-BRC-04: Panel Member

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yu, C.

Interest in proton therapy has increased dramatically in the past couple of years, especially in the United States. There certainly is an important place for proton therapy in the arsenal of cancer treatments. Its dosimetric advantage and potential for low toxicity makes it the perfect partner for photons and other cancer treatment modalities. Often there is a belief that the new technology ought to be better but many believe that they should be widely adopted in the clinic only after evidence has shown that they are at least as safe and efficacious as existing technologies, which are often less expensive.more » This is the case for proton radiotherapy. This session being both educational and debate will provide a good review of basics and technological advancement as well as a comprehensive clinical update for both proton and photon therapy. Future technology developments and how they will impact the potential dosimetric advantage of proton therapy will be discussed. Particularly the debate will focus on whether these developments will close or widen the gap between photon and proton therapy. Learning Objectives: To review challenges, limitations, and recent and future developments in proton therapy. To review challenges, limitations, recent and future developments in photon radiotherapy. To review current clinical trials and challenging clinical cases. C. Yu, No company or organization that my presentation mentions provided me with financial support. I am the Founder and CEO of Xcision Medical Systems, LLC. However, my presentation will not mention any product or technology developed by Xcision.« less

TH-D-BRC-03: Panel Member

DOE Office of Scientific and Technical Information (OSTI.GOV)

Paganetti, H.

Interest in proton therapy has increased dramatically in the past couple of years, especially in the United States. There certainly is an important place for proton therapy in the arsenal of cancer treatments. Its dosimetric advantage and potential for low toxicity makes it the perfect partner for photons and other cancer treatment modalities. Often there is a belief that the new technology ought to be better but many believe that they should be widely adopted in the clinic only after evidence has shown that they are at least as safe and efficacious as existing technologies, which are often less expensive.more » This is the case for proton radiotherapy. This session being both educational and debate will provide a good review of basics and technological advancement as well as a comprehensive clinical update for both proton and photon therapy. Future technology developments and how they will impact the potential dosimetric advantage of proton therapy will be discussed. Particularly the debate will focus on whether these developments will close or widen the gap between photon and proton therapy. Learning Objectives: To review challenges, limitations, and recent and future developments in proton therapy. To review challenges, limitations, recent and future developments in photon radiotherapy. To review current clinical trials and challenging clinical cases. C. Yu, No company or organization that my presentation mentions provided me with financial support. I am the Founder and CEO of Xcision Medical Systems, LLC. However, my presentation will not mention any product or technology developed by Xcision.« less

Stable isotope views on ecosystem function: challenging or challenged?

PubMed

Resco, Víctor; Querejeta, José I; Ogle, Kiona; Voltas, Jordi; Sebastià, Maria-Teresa; Serrano-Ortiz, Penélope; Linares, Juan C; Moreno-Gutiérrez, Cristina; Herrero, Asier; Carreira, José A; Torres-Cañabate, Patricia; Valladares, Fernando

2010-06-23

Stable isotopes and their potential for detecting various and complex ecosystem processes are attracting an increasing number of scientists. Progress is challenging, particularly under global change scenarios, but some established views have been challenged. The IX meeting of the Spanish Association of Terrestrial Ecology (AAET, Ubeda, 18-22 October 2009) hosted a symposium on the ecology of stable isotopes where the linear mixing model approach of partitioning sinks and sources of carbon and water fluxes within an ecosystem was challenged, and new applications of stable isotopes for the study of plant interactions were evaluated. Discussion was also centred on the need for networks that monitor ecological processes using stable isotopes and key ideas for fostering future research with isotopes.

Stable isotope views on ecosystem function: challenging or challenged?

PubMed Central

Resco, Víctor; Querejeta, José I.; Ogle, Kiona; Voltas, Jordi; Sebastià, Maria-Teresa; Serrano-Ortiz, Penélope; Linares, Juan C.; Moreno-Gutiérrez, Cristina; Herrero, Asier; Carreira, José A.; Torres-Cañabate, Patricia; Valladares, Fernando

2010-01-01

Stable isotopes and their potential for detecting various and complex ecosystem processes are attracting an increasing number of scientists. Progress is challenging, particularly under global change scenarios, but some established views have been challenged. The IX meeting of the Spanish Association of Terrestrial Ecology (AAET, Úbeda, 18–22 October 2009) hosted a symposium on the ecology of stable isotopes where the linear mixing model approach of partitioning sinks and sources of carbon and water fluxes within an ecosystem was challenged, and new applications of stable isotopes for the study of plant interactions were evaluated. Discussion was also centred on the need for networks that monitor ecological processes using stable isotopes and key ideas for fostering future research with isotopes. PMID:20015858

Silicon-Germanium Fast Packet Switch Developed for Communications Satellites

NASA Technical Reports Server (NTRS)

Quintana, Jorge A.

1999-01-01

Emerging multimedia applications and future satellite systems will require high-speed switching networks to accommodate high data-rate traffic among thousands of potential users. This will require advanced switching devices to enable communication between satellites. The NASA Lewis Research Center has been working closely with industry to develop a state-of-the-art fast packet switch (FPS) to fulfill this requirement. Recently, the Satellite Industry Task Force identified the need for high-capacity onboard processing switching components as one of the "grand challenges" for the satellite industry in the 21st century. In response to this challenge, future generations of onboard processing satellites will require low power and low mass components to enable transmission of services in the 100 gigabit (1011 bits) per second (Gbps) range.

Reverse innovation: an opportunity for strengthening health systems.

PubMed

Snowdon, Anne W; Bassi, Harpreet; Scarffe, Andrew D; Smith, Alexander D

2015-02-07

Canada, when compared to other OECD countries, ranks poorly with respect to innovation and innovation adoption while struggling with increasing health system costs. As a result of its failure to innovate, the Canadian health system will struggle to meet the needs and demands of both current and future populations. The purpose of this initiative was to explore if a competition-based reverse innovation challenge could mobilize and stimulate current and future leaders to identify and lead potential reverse innovation projects that address health system challenges in Canada. An open call for applications took place over a 4-month period. Applicants were enticed to submit to the competition with a $50,000 prize for the top submission to finance their project. Leaders from a wide cross-section of sectors collectively developed evaluation criteria and graded the submissions. The criteria evaluated: proof of concept, potential value, financial impact, feasibility, and scalability as well as the use of prize money and innovation team. The competition received 12 submissions from across Canada that identified potential reverse innovations from 18 unique geographical locations that were considered developing and/or emerging markets. The various submissions addressed health system challenges relating to education, mobile health, aboriginal health, immigrant health, seniors health and women's health and wellness. Of the original 12 submissions, 5 finalists were chosen and publically profiled, and 1 was chosen to receive the top prize. The results of this initiative demonstrate that a competition that is targeted to reverse innovation does have the potential to mobilize and stimulate leaders to identify reverse innovations that have the potential for system level impact. The competition also provided important insights into the capacity of Canadian students, health care providers, entrepreneurs, and innovators to propose and implement reverse innovation in the context of the Canadian health system.

Re-Shuffling of Species with Climate Disruption: A No-Analog Future for California Birds?

PubMed Central

Stralberg, Diana; Jongsomjit, Dennis; Howell, Christine A.; Snyder, Mark A.; Alexander, John D.; Wiens, John A.; Root, Terry L.

2009-01-01

By facilitating independent shifts in species' distributions, climate disruption may result in the rapid development of novel species assemblages that challenge the capacity of species to co-exist and adapt. We used a multivariate approach borrowed from paleoecology to quantify the potential change in California terrestrial breeding bird communities based on current and future species-distribution models for 60 focal species. Projections of future no-analog communities based on two climate models and two species-distribution-model algorithms indicate that by 2070 over half of California could be occupied by novel assemblages of bird species, implying the potential for dramatic community reshuffling and altered patterns of species interactions. The expected percentage of no-analog bird communities was dependent on the community scale examined, but consistent geographic patterns indicated several locations that are particularly likely to host novel bird communities in the future. These no-analog areas did not always coincide with areas of greatest projected species turnover. Efforts to conserve and manage biodiversity could be substantially improved by considering not just future changes in the distribution of individual species, but including the potential for unprecedented changes in community composition and unanticipated consequences of novel species assemblages. PMID:19724641

Visual Data Comm: A Tool for Visualizing Data Communication in the Multi Sector Planner Study

NASA Technical Reports Server (NTRS)

Lee, Hwasoo Eric

2010-01-01

Data comm is a new technology proposed in future air transport system as a potential tool to provide comprehensive data connectivity. It is a key enabler to manage 4D trajectory digitally, potentially resulting in improved flight times and increased throughput. Future concepts with data comm integration have been tested in a number of human-in-the-loop studies but analyzing the results has proven to be particularly challenging because future traffic environment in which data comm is fully enabled has assumed high traffic density, resulting in data set with large amount of information. This paper describes the motivation, design, current and potential future application of Visual Data Comm (VDC), a tool for visualizing data developed in Java using Processing library which is a tool package designed for interactive visualization programming. This paper includes an example of an application of VDC on data pertaining to the most recent Multi Sector Planner study, conducted at NASA s Airspace Operations Laboratory in 2009, in which VDC was used to visualize and interpret data comm activities

Combining a Spatial Model and Demand Forecasts to Map Future Surface Coal Mining in Appalachia

PubMed Central

Strager, Michael P.; Strager, Jacquelyn M.; Evans, Jeffrey S.; Dunscomb, Judy K.; Kreps, Brad J.; Maxwell, Aaron E.

2015-01-01

Predicting the locations of future surface coal mining in Appalachia is challenging for a number of reasons. Economic and regulatory factors impact the coal mining industry and forecasts of future coal production do not specifically predict changes in location of future coal production. With the potential environmental impacts from surface coal mining, prediction of the location of future activity would be valuable to decision makers. The goal of this study was to provide a method for predicting future surface coal mining extents under changing economic and regulatory forecasts through the year 2035. This was accomplished by integrating a spatial model with production demand forecasts to predict (1 km2) gridded cell size land cover change. Combining these two inputs was possible with a ratio which linked coal extraction quantities to a unit area extent. The result was a spatial distribution of probabilities allocated over forecasted demand for the Appalachian region including northern, central, southern, and eastern Illinois coal regions. The results can be used to better plan for land use alterations and potential cumulative impacts. PMID:26090883

Sensor Web Technology Challenges and Advancements for the Earth Science Decadal Survey Era

NASA Technical Reports Server (NTRS)

Norton, Charles D.; Moe, Karen

2011-01-01

This paper examines the Earth science decadal survey era and the role ESTO developed sensor web technologies can contribute to the scientific observations. This includes hardware and software technology advances for in-situ and in-space measurements. Also discussed are emerging areas of importance such as the potential of small satellites for sensor web based observations as well as advances in data fusion critical to the science and societal benefits of future missions, and the challenges ahead.

RNA interference in the clinic: challenges and future directions

PubMed Central

Pecot, Chad V.; Calin, George A.; Coleman, Robert L.; Lopez-Berestein, Gabriel; Sood, Anil K.

2011-01-01

Inherent difficulties with blocking many desirable targets using conventional approaches have prompted many to consider using RNA interference (RNAi) as a therapeutic approach. Although exploitation of RNAi has immense potential as a cancer therapeutic, many physiological obstacles stand in the way of successful and efficient delivery. This Review explores current challenges to the development of synthetic RNAi-based therapies and considers new approaches to circumvent biological barriers, to avoid intolerable side effects and to achieve controlled and sustained release. PMID:21160526

Deep Space Habitat Wireless Smart Plug

NASA Technical Reports Server (NTRS)

Morgan, Joseph A.; Porter, Jay; Rojdev, Kristina; Carrejo, Daniel B.; Colozza, Anthony J.

2014-01-01

NASA has been interested in technology development for deep space exploration, and one avenue of developing these technologies is via the eXploration Habitat (X-Hab) Academic Innovation Challenge. In 2013, NASA's Deep Space Habitat (DSH) project was in need of sensors that could monitor the power consumption of various devices in the habitat with added capability to control the power to these devices for load shedding in emergency situations. Texas A&M University's Electronic Systems Engineering Technology Program (ESET) in conjunction with their Mobile Integrated Solutions Laboratory (MISL) accepted this challenge, and over the course of 2013, several undergraduate students in a Capstone design course developed five wireless DC Smart Plugs for NASA. The wireless DC Smart Plugs developed by Texas A&M in conjunction with NASA's Deep Space Habitat team is a first step in developing wireless instrumentation for future flight hardware. This paper will further discuss the X-Hab challenge and requirements set out by NASA, the detailed design and testing performed by Texas A&M, challenges faced by the team and lessons learned, and potential future work on this design.

Motivators for Alzheimer's disease clinical trial participation.

PubMed

Bardach, Shoshana H; Holmes, Sarah D; Jicha, Gregory A

2018-02-01

Alzheimer's disease (AD) research progress is impeded due to participant recruitment challenges. This study seeks to better understand, from the perspective of individuals engaged in clinical trials (CTs), research motivations. Participants, or their caregivers, from AD treatment and prevention CTs were surveyed about research motivators. The 87 respondents had a mean age of 72.2, were predominantly Caucasian, 55.2% were male, and 56.3% had cognitive impairment. An overwhelming majority rated the potential to help themselves or a loved one and the potential to help others in the future as important motivators. Relatively few respondents were motivated by free healthcare, monetary rewards, or to make others happy. Recruitment efforts should focus on the potential benefit for the individual, their loved ones, and others in the future rather than free healthcare or monetary rewards.

Lessons learned from a practice-based, multi-site intervention study with nurse participants

PubMed Central

Friese, Christopher R.; Mendelsohn-Victor, Kari; Ginex, Pamela; McMahon, Carol M.; Fauer, Alex J.; McCullagh, Marjorie C.

2016-01-01

Purpose To identify challenges and solutions to the efficient conduct of a multi-site, practice-based randomized controlled trial to improve nurses’ adherence to personal protective equipment use in ambulatory oncology settings. Design The Drug Exposure Feedback and Education for Nurses’ Safety (DEFENS) study is a clustered, randomized, controlled trial. Participating sites are randomized to web-based feedback on hazardous drug exposures in the sites plus tailored messages to address barriers versus a control intervention of a web-based continuing education video. Approach The study principal investigator, the study coordinator, and two site leaders identified challenges to study implementation and potential solutions, plus potential methods to prevent logistical challenges in future studies. Findings Noteworthy challenges included variation in human subjects protection policies, grants and contracts budgeting, infrastructure for nursing-led research, and information technology variation. Successful strategies included scheduled web conferences, site-based study champions, site visits by the principal investigator, and centrally-based document preparation. Strategies to improve efficiency in future studies include early and continued engagement with contract personnel in sites, and proposed changes to the common rule concerning human subjects. The DEFENS study successfully recruited 393 nurses across 12 sites. To date, 369 have completed surveys and 174 nurses have viewed educational materials. Conclusions Multi-site studies of nursing personnel are rare and challenging to existing infrastructure. These barriers can be overcome with strong engagement and planning. Clinical Relevance Leadership engagement, onsite staff support, and continuous communication can facilitate successful recruitment to a workplace-based randomized, controlled behavioral trial. PMID:28098951

Supporting Adaptive Learning Pathways through the Use of Learning Analytics: Developments, Challenges and Future Opportunities

ERIC Educational Resources Information Center

Mavroudi, Anna; Giannakos, Michail; Krogstie, John

2018-01-01

Learning Analytics (LA) and adaptive learning are inextricably linked since they both foster technology-supported learner-centred education. This study identifies developments focusing on their interplay and emphasises insufficiently investigated directions which display a higher innovation potential. Twenty-one peer-reviewed studies are…

Thinking beyond "the Way We've Always Done It"

ERIC Educational Resources Information Center

Ohler, Lila

2013-01-01

In this article, the author discusses the future potential of electronic resources management (ERM) organization, within the development of the next-generation integrated library systems (ILS), as a very promising strategy. This also presents enormous challenges to ERM librarians though, especially on how to determine standards and workflows. The…

Adaptation of irrigation infrastructure on irrigation demands under future drought in the USA

USDA-ARS?s Scientific Manuscript database

More severe droughts in the United States will bring great challenges to irrigation water supply. Here, the authors assessed the potential adaptive effects of irrigation infrastructure under present and more extensive droughts. Based on data over 1985–2005, this study established a statistical model...

Context-Aware Recommender Systems for Learning: A Survey and Future Challenges

ERIC Educational Resources Information Center

Verbert, K.; Manouselis, N.; Ochoa, X.; Wolpers, M.; Drachsler, H.; Bosnic, I.; Duval, E.

2012-01-01

Recommender systems have been researched extensively by the Technology Enhanced Learning (TEL) community during the last decade. By identifying suitable resources from a potentially overwhelming variety of choices, such systems offer a promising approach to facilitate both learning and teaching tasks. As learning is taking place in extremely…

Potential geographic distribution of Palmer amaranth under current and future climates

USDA-ARS?s Scientific Manuscript database

Herbicide resistant weeds are increasingly becoming a major challenge for agricultural production worldwide. Palmer amaranth is an invasive annual forb that has recently emerged as one of the most widespread and severe agronomic weeds in the US, due in part to its facility for evolving herbicide res...

Historical foundations and future directions in macrosystems ecology

Treesearch

Kevin C. Rose; Rose A. Graves; Winslow D. Hansen; Brian J. Harvey; Jiangxiao Qiu; Stephen A. Wood; Carly Ziter; Monica G. Turner; Wilfried Thuiller

2017-01-01

Macrosystems ecology is an effort to understand ecological processes and interactions at the broadest spatial scales and has potential to help solve globally important social and ecological challenges. It is important to understand the intellectual legacies underpinning macrosystems ecology: How the subdiscipline fits within, builds upon, differs from and...

Humic products in agriculture: Potential benefits and research challenges-a review

USDA-ARS?s Scientific Manuscript database

Humic products have been used in cropland agriculture for several decades, but lack of widespread credibility has restricted their use to small proportions of farmers. To improve the credibility of humic products, we identify four knowledge gaps and propose pathways of future action to close these g...

Climate change response framework overview: Chapter 1

Treesearch

Chris Swanston; Maria Janowiak; Patricia Butler

2012-01-01

Managers currently face the immense challenge of anticipating the effects of climate change on forest ecosystems and then developing and applying management responses for adapting forests to future conditions. The Climate Change Response Framework (CCRF) is a highly collaborative approach to helping land managers understand the potential effects of climate change on...

Powder River outlook stays healthy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stremel, K.

1984-08-01

Well drilling activity in Wyoming's Powder River Basin is discussed. Operators are taking advantage of favorable economic advantages to tap the area's multiple pay potential and challenge its high success rate reputation. A significant amount of exploration and development can be expected in the future due to the recent discovery of high-flowing wells.

The New Literacies of Online Reading Comprehension: Future Directions

ERIC Educational Resources Information Center

Coiro, Julie

2012-01-01

Research in four areas has the potential to dramatically improve how practitioners address the challenges of integrating digital texts and tasks into their literacy curriculum. Advances in defining and measuring key components of online reading comprehension are rapidly emerging. In addition, instructional models, such as Internet reciprocal…

THE POTENTIAL MID-TERM ROLE OF NUCLEAR POWER IN THE UNITED STATES: A SCENARIO ANALYSIS USING MARKAL

EPA Science Inventory

With all nations facing enormous challenges related to energy security, sustainability and environmental quality, nuclear power is likely to play an increasingly important role in the future. In particular, the life-cycle emissions of criteria pollutants and greenhouse gases (GHG...

Productivity limits and potentials of the principles of conservation agriculture

USDA-ARS?s Scientific Manuscript database

One of the primary challenges of our time is to feed a growing and more demanding world population with reduced external inputs and minimal environmental impacts, all under more variable and extreme climate conditions of the future. Conservation agriculture (CA) represents a set of three crop manage...

The Instrument of the Future: Computers in Education.

ERIC Educational Resources Information Center

Leonard, Rex; LeCroy, Barbara

Before computers will be able to fulfill their potential in education, two major challenges must be overcome--the lack of well-trained teachers and a lack of general knowledge about software and its capabilities. Teachers must acquire some computer literacy skills, including programming, word processing, materials generation and record keeping. In…

Challenges of Conducting Research With Young Offenders With Traumatic Brain Injury.

PubMed

OʼRourke, Conall; Templeton, Michelle; Cohen, Miriam H; Linden, Mark A

2018-05-31

The purpose of this commentary is to highlight the challenges encountered when conducting research with young offenders. This is drawn from the first-hand experience of 3 researchers working on separate projects within this environment. Young offenders present as a complex clinical population with high levels of illiteracy, substance abuse, and mental health issues. Significant planning is therefore required before working with this group. Consideration must be given to the heterogeneity of prison populations alongside the potential limitations of datacollection methods, in particular, reliance on self-report. The capacity of young offenders to comprehend and effectively engage with research is also of concern, posing issues of both a practical and ethical nature. The absence of a consistent "research culture" within prison environments poses further practical challenges, potentially also placing significant burden on both researchers and prison resources. The challenges discussed in this article may help inform future studies in the area and emphasize the need for greater critical reflection among researchers conducting work of this type.

Summary of the DREAM8 Parameter Estimation Challenge: Toward Parameter Identification for Whole-Cell Models.

PubMed

Karr, Jonathan R; Williams, Alex H; Zucker, Jeremy D; Raue, Andreas; Steiert, Bernhard; Timmer, Jens; Kreutz, Clemens; Wilkinson, Simon; Allgood, Brandon A; Bot, Brian M; Hoff, Bruce R; Kellen, Michael R; Covert, Markus W; Stolovitzky, Gustavo A; Meyer, Pablo

2015-05-01

Whole-cell models that explicitly represent all cellular components at the molecular level have the potential to predict phenotype from genotype. However, even for simple bacteria, whole-cell models will contain thousands of parameters, many of which are poorly characterized or unknown. New algorithms are needed to estimate these parameters and enable researchers to build increasingly comprehensive models. We organized the Dialogue for Reverse Engineering Assessments and Methods (DREAM) 8 Whole-Cell Parameter Estimation Challenge to develop new parameter estimation algorithms for whole-cell models. We asked participants to identify a subset of parameters of a whole-cell model given the model's structure and in silico "experimental" data. Here we describe the challenge, the best performing methods, and new insights into the identifiability of whole-cell models. We also describe several valuable lessons we learned toward improving future challenges. Going forward, we believe that collaborative efforts supported by inexpensive cloud computing have the potential to solve whole-cell model parameter estimation.

Summary of the DREAM8 Parameter Estimation Challenge: Toward Parameter Identification for Whole-Cell Models

PubMed Central

Karr, Jonathan R.; Williams, Alex H.; Zucker, Jeremy D.; Raue, Andreas; Steiert, Bernhard; Timmer, Jens; Kreutz, Clemens; Wilkinson, Simon; Allgood, Brandon A.; Bot, Brian M.; Hoff, Bruce R.; Kellen, Michael R.; Covert, Markus W.; Stolovitzky, Gustavo A.; Meyer, Pablo

2015-01-01

Whole-cell models that explicitly represent all cellular components at the molecular level have the potential to predict phenotype from genotype. However, even for simple bacteria, whole-cell models will contain thousands of parameters, many of which are poorly characterized or unknown. New algorithms are needed to estimate these parameters and enable researchers to build increasingly comprehensive models. We organized the Dialogue for Reverse Engineering Assessments and Methods (DREAM) 8 Whole-Cell Parameter Estimation Challenge to develop new parameter estimation algorithms for whole-cell models. We asked participants to identify a subset of parameters of a whole-cell model given the model’s structure and in silico “experimental” data. Here we describe the challenge, the best performing methods, and new insights into the identifiability of whole-cell models. We also describe several valuable lessons we learned toward improving future challenges. Going forward, we believe that collaborative efforts supported by inexpensive cloud computing have the potential to solve whole-cell model parameter estimation. PMID:26020786

Safeguards Considerations for Thorium Fuel Cycles

DOE PAGES

Worrall, Louise G.; Worrall, Andrew; Flanagan, George F.; ...

2016-04-21

We report that by around 2025, thorium-based fuel cycles are likely to be deployed internationally. States such as China and India are pursuing research, development, and deployment pathways toward a number of commercial-scale thorium fuel cycles, and they are already building test reactors and the associated fuel cycle infrastructure. In the future, the potential exists for these emerging programs to sell, export, and deploy thorium fuel cycle technology in other states. Without technically adequate international safeguards protocols and measures in place, any future potential clandestine misuse of these fuel cycles could go undetected, compromising the deterrent value of these protocolsmore » and measures. The development of safeguards approaches for thorium-based fuel cycles is therefore a matter of some urgency. Yet, the focus of the international safeguards community remains mainly on safeguarding conventional 235U- and 239Pu-based fuel cycles while the safeguards challenges of thorium-uranium fuel cycles remain largely uninvestigated. This raises the following question: Is the International Atomic Energy Agency and international safeguards system ready for thorium fuel cycles? Furthermore, is the safeguards technology of today sufficiently mature to meet the verification challenges posed by thorium-based fuel cycles? In defining these and other related research questions, the objectives of this paper are to identify key safeguards considerations for thorium-based fuel cycles and to call for an early dialogue between the international safeguards and the nuclear fuel cycle communities to prepare for the potential safeguards challenges associated with these fuel cycles. In this paper, it is concluded that directed research and development programs are required to meet the identified safeguards challenges and to take timely action in preparation for the international deployment of thorium fuel cycles.« less

Design Flexibility for Uncertain Distributed Generation from Photovoltaics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Palmintier, Bryan; Krishnamurthy, Dheepak; Wu, Hongyu

2016-12-12

Uncertainty in the future adoption patterns for distributed energy resources (DERs) introduces a challenge for electric distribution system planning. This paper explores the potential for flexibility in design - also known as real options - to identify design solutions that may never emerge when future DER patterns are treated as deterministic. A test case for storage system design with uncertain distributed generation for solar photovoltaics (DGPV) demonstrates this approach and is used to study sensitivities to a range of techno-economic assumptions.

Performance improvement CME for quality: challenges inherent to the process.

PubMed

Vakani, Farhan Saeed; O'Beirne, Ronan

2015-01-01

The purpose of this paper is to discuss the perspective debates upon the real-time challenges for a three-staged Performance Improvement Continuing Medical Education (PI-CME) model, an innovative and potential approach for future CME, to inform providers to think, prepare and to act proactively. In this discussion, the challenges associated for adopting the American Medical Association's three-staged PI-CME model are reported. Not many institutions in USA are using a three-staged performance improvement model and then customizing it to their own healthcare context for the specific targeted audience. They integrate traditional CME methods with performance and quality initiatives, and linking with CME credits. Overall the US health system is interested in a structured PI-CME model with the potential to improve physicians practicing behaviors. Knowing the dearth of evidence for applying this structured performance improvement methodology into the design of CME activities, and the lack of clarity on challenges inherent to the process that learners and providers encounter. This paper establishes all-important first step to render the set of challenges for a three-staged PI-CME model.

Preparing future fisheries professionals to make good decisions

USGS Publications Warehouse

Colvin, Michael E.; Peterson, James T.

2017-01-01

Future fisheries professionals will face decision-making challenges in an increasingly complex field of fisheries management. Though fisheries students are well trained in the use of the scientific method to understand the natural world, they are rarely exposed to structured decision making (SDM) as part of an undergraduate or graduate education. Specifically, SDM encourages users (e.g., students, managers) to think critically and communicate the problem and then identify specific, measurable objectives as they relate to the problem. Next, users must think critically and creatively about management alternatives that can be used to meet the objectives—there must be more than one alternative or there is no decision to be made. Lastly, the management alternatives are evaluated with regard to how likely they are to succeed in terms of multiple, possibly completing, objectives, such as how stakeholder groups value outcomes of management actions versus monetary cost. We believe that exposure to SDM and its elements is an important part of preparing future fisheries professional to meet the challenges they may face. These challenges include reduced budgets, the growth of potentially competing natural resource interest groups, and stakeholder desire to be involved in management decisions affecting public trust resources, just to name a few.

Non-governmental organizations in international health: past successes, future challenges.

PubMed

Gellert, G A

1996-01-01

Non-governmental organizations, or NGOs, are increasingly instrumental to the implementation of international health programs. Following an overview of current conditions in global health and the problems that could be targeted by NGOs, this article describes the activities and philosophies of several representative approaches in this sector. The attributes of NGOs that increase their potential effectiveness are discussed, including ability to reach areas of severe need, promotion of local involvement, low cost of operations, adaptiveness and innovation, independence, and sustainability. A summary is provided of major future challenges in international health that may be addressed by NGOs, with particular emphasis on tobacco-related disease, communicable diseases and the AIDS epidemic, maternal mortality and women's health, injury prevention and control, and the need to secure durable financial support.

Building resilience through exposure to stressors: The effects of challenges versus hindrances.

PubMed

Crane, Monique F; Searle, Ben J

2016-10-01

This paper explores the potential for certain types of stressors to build resilience in the occupational setting. Using the challenge-hindrance stressor framework (Cavanaugh, Boswell, Roehling, & Boudreau, 2000), we propose that challenge stressors have the potential to promote the capacity for resilience, whereas hindrance stressors experienced in the workplace erode resilient functioning. Employing a 2-wave longitudinal design we examined the effects of challenge and hindrance stressors on psychological resilience and strain 3 months later. Two-hundred and 8 working adults (48.1% female) participated in both surveys. Findings indicated that Time 1 challenge stressors had a significant effect on psychological resilience 3 months later (Time 2). In contrast, Time 1 hindrance stressors positively predicted Time 2 strain and negatively predicted psychological resilience. Moreover, resilience mediated the relationship between Time 1 stressors and Time 2 strain. These results demonstrate the potential positive and negative impacts of workplace stressor types on psychological resilience, and provide an exploration of a mechanism through which challenge and hindrance stressors influence well-being. This analysis also investigated the role of resilience in moderating the relationship between hindrances and strain. Some evidence emerged for the moderating role of resilience in the hindrance-strain relationship. The implications of these findings and directions for future research are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Modeling the Energy Use of a Connected and Automated Transportation System (Poster)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gonder, J.; Brown, A.

Early research points to large potential impacts of connected and automated vehicles (CAVs) on transportation energy use - dramatic savings, increased use, or anything in between. Due to a lack of suitable data and integrated modeling tools to explore these complex future systems, analyses to date have relied on simple combinations of isolated effects. This poster proposes a framework for modeling the potential energy implications from increasing penetration of CAV technologies and for assessing technology and policy options to steer them toward favorable energy outcomes. Current CAV modeling challenges include estimating behavior change, understanding potential vehicle-to-vehicle interactions, and assessing trafficmore » flow and vehicle use under different automation scenarios. To bridge these gaps and develop a picture of potential future automated systems, NREL is integrating existing modeling capabilities with additional tools and data inputs to create a more fully integrated CAV assessment toolkit.« less

PET/MRI – Technical Review

PubMed Central

Muzic, Raymond F.; DiFilippo, Frank P.

2015-01-01

PET/MR is a hybrid imaging technology with the potential to combine the molecular and functional information of PET with the soft-tissue contrast of MR. Herein we review the technical features and challenges of putting these different technologies together. We emphasize the conceptual to make the material accessible to a wide audience. We begin by reviewing PET/CT, a more mature multi-modality imaging technology, to provide a basis for comparison to the history of PET/MR development. We discuss the motivation and challenges of PET/MR and different approaches that have been used to meet the challenges. We conclude with a speculation about the future of this exciting imaging method. PMID:25497909

New challenges of public health: bringing the future of personalised healthcare into focus.

PubMed

Ricciardi, Walter; Boccia, Stefania

2017-10-01

The greater personalization of healthcare represents a driver of innovation for research, and for the healthcare systems and industries as a whole. Still policy-makers, healthcare professionals, citizens and private companies need to take some steps to realize the potential for such a radical shift. In this paper, we illustrate the challenges, the benefits and consequences that might accompany the implementation of personalized healthcare, and the steps that policy-makers and practitioners would need to take to realise its potential. Six main prerequisites for radical change in healthcare are presented, that include achieving better genetic literacy for professionals and for the public; engaging citizen in the discourse; improved governance, consent and trust in healthcare; feeding and harnessing the data-knowledge cycle for better health; adopting and adapting the Health Technology Assessment framework for the evaluation of the new technologies; and retaining humanity and community in health and care. Some of these concepts originate from a discussion on the future of health and healthcare, looking at least 15-20 years into the future, that we had at the end of 2016 at Ickworth with an international group of experts, under the aegis of the PHG Foundation. © The Author 2017. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.

TH-D-BRC-00: Educational Point Counter/Point: Has Photon RT Hit the Limits?

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

Interest in proton therapy has increased dramatically in the past couple of years, especially in the United States. There certainly is an important place for proton therapy in the arsenal of cancer treatments. Its dosimetric advantage and potential for low toxicity makes it the perfect partner for photons and other cancer treatment modalities. Often there is a belief that the new technology ought to be better but many believe that they should be widely adopted in the clinic only after evidence has shown that they are at least as safe and efficacious as existing technologies, which are often less expensive.more » This is the case for proton radiotherapy. This session being both educational and debate will provide a good review of basics and technological advancement as well as a comprehensive clinical update for both proton and photon therapy. Future technology developments and how they will impact the potential dosimetric advantage of proton therapy will be discussed. Particularly the debate will focus on whether these developments will close or widen the gap between photon and proton therapy. Learning Objectives: To review challenges, limitations, and recent and future developments in proton therapy. To review challenges, limitations, recent and future developments in photon radiotherapy. To review current clinical trials and challenging clinical cases. C. Yu, No company or organization that my presentation mentions provided me with financial support. I am the Founder and CEO of Xcision Medical Systems, LLC. However, my presentation will not mention any product or technology developed by Xcision.« less

Hydrogen production from algal biomass - Advances, challenges and prospects.

PubMed

Show, Kuan-Yeow; Yan, Yuegen; Ling, Ming; Ye, Guoxiang; Li, Ting; Lee, Duu-Jong

2018-06-01

Extensive effort is being made to explore renewable energy in replacing fossil fuels. Biohydrogen is a promising future fuel because of its clean and high energy content. A challenging issue in establishing hydrogen economy is sustainability. Biohydrogen has the potential for renewable biofuel, and could replace current hydrogen production through fossil fuel thermo-chemical processes. A promising source of biohydrogen is conversion from algal biomass, which is abundant, clean and renewable. Unlike other well-developed biofuels such as bioethanol and biodiesel, production of hydrogen from algal biomass is still in the early stage of development. There are a variety of technologies for algal hydrogen production, and some laboratory- and pilot-scale systems have demonstrated a good potential for full-scale implementation. This work presents an elucidation on development in biohydrogen encompassing biological pathways, bioreactor designs and operation and techno-economic evaluation. Challenges and prospects of biohydrogen production are also outlined. Copyright © 2018 Elsevier Ltd. All rights reserved.

Charting the landscape of priority problems in psychiatry, part 1: classification and diagnosis.

PubMed

Stephan, Klaas E; Bach, Dominik R; Fletcher, Paul C; Flint, Jonathan; Frank, Michael J; Friston, Karl J; Heinz, Andreas; Huys, Quentin J M; Owen, Michael J; Binder, Elisabeth B; Dayan, Peter; Johnstone, Eve C; Meyer-Lindenberg, Andreas; Montague, P Read; Schnyder, Ulrich; Wang, Xiao-Jing; Breakspear, Michael

2016-01-01

Contemporary psychiatry faces major challenges. Its syndrome-based disease classification is not based on mechanisms and does not guide treatment, which largely depends on trial and error. The development of therapies is hindered by ignorance of potential beneficiary patient subgroups. Neuroscientific and genetics research have yet to affect disease definitions or contribute to clinical decision making. In this challenging setting, what should psychiatric research focus on? In two companion papers, we present a list of problems nominated by clinicians and researchers from different disciplines as candidates for future scientific investigation of mental disorders. These problems are loosely grouped into challenges concerning nosology and diagnosis (this Personal View) and problems related to pathogenesis and aetiology (in the companion Personal View). Motivated by successful examples in other disciplines, particularly the list of Hilbert's problems in mathematics, this subjective and eclectic list of priority problems is intended for psychiatric researchers, helping to re-focus existing research and providing perspectives for future psychiatric science. Copyright © 2016 Elsevier Ltd. All rights reserved.

Gulf War Illness: Challenges Persist.

PubMed

Nettleman, Mary

2015-01-01

It has been more than 20 years since the United States and coalition forces entered Kuwait and Iraq. Actual combat was of remarkably short duration: less than 1 week of sustained ground activity and 6 weeks of air missions. Thus, it was surprising when approximately 200,000 returning US veterans were affected by a chronic multi-symptom illness that came to be known as Gulf War Illness (GWI). There were many challenges in investigating GWI, not least of which was that it took several years before the condition was officially taken seriously. There were multiple exposures to potentially causal agents on and off the battlefield, but these exposures were documented incompletely if at all, leaving epidemiologists to rely on self-report for information. In the past 2 years, significant controversy has arisen over the future directions of the field. Despite these challenges, several studies have implicated exposure to acetylcholinesterase inhibitors such as pyridostigmine bromide in the genesis of the condition. The story of GWI can inform research into other conditions and guide future work on veterans' health.

Joint STFC Futures/BIR workshop "Cancer care: new detector and sensor technologies and their potential impact", Harwell Oxford, 5-6 October 2011.

PubMed

Camanzi, B; Green, S

2012-12-01

The workshop "Cancer care: new detector and sensor technologies and their potential impact", organised jointly by the Science and Technology Facilities Council (STFC) and the British Institute of Radiology, brought together representatives from the cancer community (clinicians, medical physicists, National Health Service representatives and general practitioners with an interest in cancer) and STFC-supported scientists involved in basic research in physics and technology. The workshop aimed to raise awareness of the cancer challenge, share knowledge and identify novel solutions in the area of detectors and sensors to addressing the cancer challenge. A further aim of this workshop was to commence discussion on the formation of new multidisciplinary community networks. The workshop identified the synergies between the two communities and the potential for developing new collaborative ideas and projects.

Climate Change and Sea Level Rise: A Challenge to Science and Society

NASA Astrophysics Data System (ADS)

Plag, H.

2009-12-01

Society is challenged by the risk of an anticipated rise of coastal Local Sea Level (LSL) as a consequence of future global warming. Many low-lying and often subsiding and densely populated coastal areas are under risk of increased inundation, with potentially devastating consequences for the global economy, society, and environment. Faced with a trade-off between imposing the very high costs of coastal protection and adaptation upon today's national economies and leaving the costs of potential major disasters to future generations, governments and decision makers are in need of scientific support for the development of mitigation and adaptation strategies for the coastal zone. Low-frequency to secular changes in LSL are the result of many interacting Earth system processes. The complexity of the Earth system makes it difficult to predict Global Sea Level (GSL) rise and, even more so, LSL changes over the next 100 to 200 years. Humans have re-engineered the planet and changed major features of the Earth surface and the atmosphere, thus ruling out extrapolation of past and current changes into the future as a reasonable approach. The risk of rapid changes in ocean circulation and ice sheet mass balance introduces the possibility of unexpected changes. Therefore, science is challenged with understanding and constraining the full range of plausible future LSL trajectories and with providing useful support for informed decisions. In the face of largely unpredictable future sea level changes, monitoring of the relevant processes and development of a forecasting service on realistic time scales is crucial as decision support. Forecasting and "early warning" for LSL rise would have to aim at decadal time scales, giving coastal managers sufficient time to react if the onset of rapid changes would require an immediate response. The social, environmental, and economic risks associated with potentially large and rapid LSL changes are enormous. Therefore, in the light of the current uncertainties and the unpredictable nature of some of the forcing processes for LSL changes, the focus of scientific decision support may have to shift from projections of LSL trajectories on century time scales to the development of models and monitoring systems for a forecasting service on decadal time scales. The requirements for such a LSL forecasting service and the current obstacles will be discussed.

How will climate novelty influence ecological forecasts? Using the Quaternary to assess future reliability.

PubMed

Fitzpatrick, Matthew C; Blois, Jessica L; Williams, John W; Nieto-Lugilde, Diego; Maguire, Kaitlin C; Lorenz, David J

2018-03-23

Future climates are projected to be highly novel relative to recent climates. Climate novelty challenges models that correlate ecological patterns to climate variables and then use these relationships to forecast ecological responses to future climate change. Here, we quantify the magnitude and ecological significance of future climate novelty by comparing it to novel climates over the past 21,000 years in North America. We then use relationships between model performance and climate novelty derived from the fossil pollen record from eastern North America to estimate the expected decrease in predictive skill of ecological forecasting models as future climate novelty increases. We show that, in the high emissions scenario (RCP 8.5) and by late 21st century, future climate novelty is similar to or higher than peak levels of climate novelty over the last 21,000 years. The accuracy of ecological forecasting models is projected to decline steadily over the coming decades in response to increasing climate novelty, although models that incorporate co-occurrences among species may retain somewhat higher predictive skill. In addition to quantifying future climate novelty in the context of late Quaternary climate change, this work underscores the challenges of making reliable forecasts to an increasingly novel future, while highlighting the need to assess potential avenues for improvement, such as increased reliance on geological analogs for future novel climates and improving existing models by pooling data through time and incorporating assemblage-level information. © 2018 John Wiley & Sons Ltd.

The Benefits and Future of Standards: Metadata and Beyond

NASA Astrophysics Data System (ADS)

Stracke, Christian M.

This article discusses the benefits and future of standards and presents the generic multi-dimensional Reference Model. First the importance and the tasks of interoperability as well as quality development and their relationship are analyzed. Especially in e-Learning their connection and interdependence is evident: Interoperability is one basic requirement for quality development. In this paper, it is shown how standards and specifications are supporting these crucial issues. The upcoming ISO metadata standard MLR (Metadata for Learning Resource) will be introduced and used as example for identifying the requirements and needs for future standardization. In conclusion a vision of the challenges and potentials for e-Learning standardization is outlined.

Teaching for Present "and Future" Competency: A Productive Focus for Professional Learning

ERIC Educational Resources Information Center

Hipkins, Rosemary; McDowall, Sue

2013-01-01

The key competencies are a potentially transformative feature of the New Zealand Curriculum. However, the way in which they have been understood and implemented in schools points to tensions and challenges that may prevent them from acting as agents of curriculum change. One recent researcher/practitioner partnership developed materials that show…

Teaching Sustainability in Higher Education: Pedagogical Styles That Make a Difference

ERIC Educational Resources Information Center

Seatter, Carol Scarff; Ceulemans, Kim

2017-01-01

The challenge of teaching sustainable development in higher education can mean that students--as future citizens--are left without insight, commitment, or a sense of their position regarding meaningful beliefs and actions related to sustainability. A paradox arises when educators approach a sustainability curriculum that has the potential to…

Assessment Approaches in Massive Open Online Courses: Possibilities, Challenges and Future Directions

ERIC Educational Resources Information Center

Xiong, Yao; Suen, Hoi K.

2018-01-01

The development of massive open online courses (MOOCs) has launched an era of large-scale interactive participation in education. While massive open enrolment and the advances of learning technology are creating exciting potentials for lifelong learning in formal and informal ways, the implementation of efficient and effective assessment is still…

Integrating climate change considerations into forest management tools and training

Treesearch

Linda M. Nagel; Christopher W. Swanston; Maria K. Janowiak

2010-01-01

Silviculturists are currently facing the challenge of developing management strategies that meet broad ecological and social considerations in spite of a high degree of uncertainty in future climatic conditions. Forest managers need state-of-the-art knowledge about climate change and potential impacts to facilitate development of silvicultural objectives and...

Reforming system of professional training of future specialists by taking into account production automation requirements

NASA Astrophysics Data System (ADS)

Saigushev, N. Y.; Vedeneeva, O. A.; Melekhova, Yu B.

2018-05-01

The accelerating scientific development, equipment upgrade, emergence of new technologies and intensive growth and use of nano-, robotic, bio- and other perspective technologies require the formation of scientific and technological potential in Russia which is suitable for present-day challenges of the global technological growth.

Comparative and International Education: Policy Transfer, Context Sensitivity and Professional Development

ERIC Educational Resources Information Center

Crossley, Michael; Watson, Keith

2009-01-01

This paper examines the intellectual and professional contribution of comparative and international studies to the field of education. It explores the nature of the challenges that are currently being faced, and assesses its potential for the advancement of future teaching, research and professional development. Attention is paid to the place of…

The Challenge for the Modern Day Operational Leader: Succeeding in the Realm of Civilian Organizations

DTIC Science & Technology

2009-10-23

leadership styles will be used to analyze and critique the most productive characteristics and traits. The conclusion will reveal the most successful... leadership styles , while recommendations will propose actions intended to ensure future military leaders are groomed and selected based on their potential for success.

Satisfaction of Outcome Achievement with Web-Enhanced Teaching Strategies in Nursing Education

ERIC Educational Resources Information Center

Thornock, Susan B.

2013-01-01

The future of distance and Web-enhanced education and the use of technology are becoming more advantageous to a growing population. Nursing education has been encouraged to incorporate these teaching-learning methods. Changes in nursing education and the teaching-learning environment have the potential to challenge the preservation of nursing…

Ecological Footprinting: Its Potential as a Tool for Change in Preservice Teacher Education

ERIC Educational Resources Information Center

O'Gorman, Lyndal; Davis, Julie

2013-01-01

Environmental and sustainability issues pose challenges for society. Although education is seen as being a contributor to addressing sustainability, teacher education has been slow to act in preparing future teachers to teach sustainability. Recent Australian curriculum documents nominate sustainability as one of three cross-curriculum priorities.…

Mentors' Perspectives on Group Mentorship: A Descriptive Study of Two Programs in Child and Adolescent Psychiatry

ERIC Educational Resources Information Center

Alleyne, Shirley Diana; Horner, Michelle Schnabel; Walter, Garry; Fleisher, Stacia Hall; Arzubi, Eric; Martin, Andres

2009-01-01

Objective: The authors assess mentors' perceptions of mentoring and experiences participating in an intensive, small-group mentorship program, with particular attention to potential challenges in their retention and the recruitment of new mentors to similar, future programs. Methods: Similar group mentorship programs were implemented at two child…

Chapter 10: Research and Deployment of Renewable Bioenergy Production from Microalgae

DOE Office of Scientific and Technical Information (OSTI.GOV)

Laurens, Lieve M; Glasser, Melodie

Recent progress towards the implementation of renewable bioenergy production has included microalgae, which have potential to significantly contribute to a viable future bioeconomy. In a current challenging energy landscape, where an increased demand for renewable fuels is projected and accompanied by plummeting fossil fuels' prices, economical production of algae-based fuels becomes more challenging. However, in the context of mitigating carbon emissions with the potential of algae to assimilate large quantities of CO2, there is a route to drive carbon sequestration and utilization to support a sustainable and secure global energy future. This chapter places international energy policy in the contextmore » of the current and projected energy landscape. The contribution that algae can make, is summarized as both a conceptual contribution as well as an overview of the commercial infrastructure installed globally. Some of the major recent developments and crucial technology innovations are the results of global government support for the development of algae-based bioenergy, biofuels and bioproduct applications, which have been awarded as public private partnerships and are summarized in this chapter.« less

Time-Resolved Diffuse Optical Spectroscopy and Imaging Using Solid-State Detectors: Characteristics, Present Status, and Research Challenges.

PubMed

Alayed, Mrwan; Deen, M Jamal

2017-09-14

Diffuse optical spectroscopy (DOS) and diffuse optical imaging (DOI) are emerging non-invasive imaging modalities that have wide spread potential applications in many fields, particularly for structural and functional imaging in medicine. In this article, we review time-resolved diffuse optical imaging (TR-DOI) systems using solid-state detectors with a special focus on Single-Photon Avalanche Diodes (SPADs) and Silicon Photomultipliers (SiPMs). These TR-DOI systems can be categorized into two types based on the operation mode of the detector (free-running or time-gated). For the TR-DOI prototypes, the physical concepts, main components, figures-of-merit of detectors, and evaluation parameters are described. The performance of TR-DOI prototypes is evaluated according to the parameters used in common protocols to test DOI systems particularly basic instrumental performance (BIP). In addition, the potential features of SPADs and SiPMs to improve TR-DOI systems and expand their applications in the foreseeable future are discussed. Lastly, research challenges and future developments for TR-DOI are discussed for each component in the prototype separately and also for the entire system.

The Potential of Automatic Word Comparison for Historical Linguistics.

PubMed

List, Johann-Mattis; Greenhill, Simon J; Gray, Russell D

2017-01-01

The amount of data from languages spoken all over the world is rapidly increasing. Traditional manual methods in historical linguistics need to face the challenges brought by this influx of data. Automatic approaches to word comparison could provide invaluable help to pre-analyze data which can be later enhanced by experts. In this way, computational approaches can take care of the repetitive and schematic tasks leaving experts to concentrate on answering interesting questions. Here we test the potential of automatic methods to detect etymologically related words (cognates) in cross-linguistic data. Using a newly compiled database of expert cognate judgments across five different language families, we compare how well different automatic approaches distinguish related from unrelated words. Our results show that automatic methods can identify cognates with a very high degree of accuracy, reaching 89% for the best-performing method Infomap. We identify the specific strengths and weaknesses of these different methods and point to major challenges for future approaches. Current automatic approaches for cognate detection-although not perfect-could become an important component of future research in historical linguistics.

The Potential of Automatic Word Comparison for Historical Linguistics

PubMed Central

Greenhill, Simon J.; Gray, Russell D.

2017-01-01

The amount of data from languages spoken all over the world is rapidly increasing. Traditional manual methods in historical linguistics need to face the challenges brought by this influx of data. Automatic approaches to word comparison could provide invaluable help to pre-analyze data which can be later enhanced by experts. In this way, computational approaches can take care of the repetitive and schematic tasks leaving experts to concentrate on answering interesting questions. Here we test the potential of automatic methods to detect etymologically related words (cognates) in cross-linguistic data. Using a newly compiled database of expert cognate judgments across five different language families, we compare how well different automatic approaches distinguish related from unrelated words. Our results show that automatic methods can identify cognates with a very high degree of accuracy, reaching 89% for the best-performing method Infomap. We identify the specific strengths and weaknesses of these different methods and point to major challenges for future approaches. Current automatic approaches for cognate detection—although not perfect—could become an important component of future research in historical linguistics. PMID:28129337

Prospective Longitudinal Studies of Infant Siblings of Children With Autism: Lessons Learned and Future Directions.

PubMed

Szatmari, Peter; Chawarska, Katarzyna; Dawson, Geraldine; Georgiades, Stelios; Landa, Rebecca; Lord, Catherine; Messinger, Daniel S; Thurm, Audrey; Halladay, Alycia

2016-03-01

The objectives of this review are to highlight the impact of the first decade of high-risk (HR) infant sibling work in autism spectrum disorder (ASD) and to identify potential areas of translational focus for the next decade of research. A group of clinicians and researchers in ASD working both inside and outside of the HR design met on a regular basis to review the infant sibling research, and came to an agreement on areas that had changed clinical practice and areas that had the potential to change practice with further research. The group then outlined several methodological and translational challenges that must be addressed in the next decade of research if the field is to reach its potential. The review concluded that the HR design has yielded an understanding that ASD often, but not always, begins to emerge between 6 and 18 months, with early signs affecting social communication. Research using the HR design has also allowed a better understanding of the sibling recurrence risk (between 10% and 20%). Emerging areas of interest include the developmental trajectories of social communications skills in the early years, the expression of a milder phenotype in siblings not affected with ASD, and the possibility that early intervention with infant siblings may improve outcomes for those with ASD. Important challenges for the future include linking screening to intervention, collecting large sample sizes while ensuring cross-site reliability, and building in capacity for replication. Although there are significant methodological and translational challenges for high-risk infant sibling research, the potential of this design to improve long-term outcomes of all children with ASD is substantial. Published by Elsevier Inc.

Prospective Longitudinal Studies of Infant Siblings of Children With Autism: Lessons Learned and Future Directions

PubMed Central

Szatmari, Peter; Chawarska, Katarzyna; Dawson, Geraldine; Georgiades, Stelios; Landa, Rebecca; Lord, Catherine; Messinger, Daniel S.; Thurm, Audrey; Halladay, Alycia

2016-01-01

Objective The objectives of this review are to highlight the impact of the first decade of high-risk (HR) infant sibling work in autism spectrum disorder (ASD) and to identify potential areas of translational focus for the next decade of research. Method A group of clinicians and researchers in ASD working both inside and outside of the HR design met on a regular basis to review the infant sibling research, and came to an agreement on areas that had changed clinical practice and areas that had the potential to change practice with further research. The group then outlined several methodological and translational challenges that must be addressed in the next decade of research if the field is to reach its potential. Results The review concluded that the HR design has yielded an understanding that ASD often, but not always, begins to emerge between 6 and 18 months, with early signs affecting social communication. Research using the HR design has also allowed a better understanding of the sibling recurrence risk (between 10% and 20%). Emerging areas of interest include the developmental trajectories of social communications skills in the early years, the expression of a milder phenotype in siblings not affected with ASD, and the possibility that early intervention with infant siblings may improve outcomes for those with ASD. Important challenges for the future include linking screening to intervention, collecting large sample sizes while ensuring cross-site reliability, and building in capacity for replication. Conclusion Although there are significant methodological and translational challenges for high-risk infant sibling research, the potential of this design to improve long-term outcomes of all children with ASD is substantial. PMID:26903251

Through a glass darkly: economics and personalised medicine.

PubMed

Haycox, Alan; Pirmohamed, Munir; McLeod, Claire; Houten, Rachel; Richards, Sarah

2014-11-01

Personalised medicine and pharmacogenetic-test-guided treatment strategies will be of increasing importance in the future, both in terms of healthcare provision and evaluation. It is well recognised that significant variability exists in the response of patients to drugs resulting from genetic or biological variations; however, we are only now gradually becoming aware of the complexities involved. Enormous variability occurs in the risk-benefit ratio that will be experienced by each individual patient as a consequence of their overall genetic make-up. Although not a panacea, enhanced scientific knowledge of the genetic basis for such variability offers the potential for a more 'tailored' approach to prescribing in the future, making it more closely attuned to the needs of the individual patient. Such 'personalised' medicine has the potential to revolutionise care provision in a manner that provides a range of challenges to current structures and processes of 'conventional' healthcare delivery. The aim of this paper is to outline such challenges and analyse potential ways in which they may be addressed in the future. It provides non-expert readers with a non-technical case study of the complexities inherent in the evaluation of a pharmacogenetic-test-guided treatment strategy from a health economic perspective. Wherever possible, technical issues have been minimised; however, references are provided for readers who wish to enhance their knowledge of the pharmacological basis of the case study of cytochrome P450 test-guided treatment. The case study aims simply to illustrate the approach and difficulties encountered in the health economic evaluation of complex pharmacogenetic technologies. Such technologies present a range of new and complex issues which have crucial implications for health economists attempting to obtain an accurate assessment of the 'value' of the technology in clinical practice in an array of patient subgroups. Personalised medicine is the future and this paper highlights how pharmaceutical manufacturers, clinicians, regulators and other stakeholders must all play their part in the inevitable and accelerating move into this complex and uncertain future.

Food allergy: opportunities and challenges in the clinical practice of allergy and immunology.

PubMed

James, John M

2004-10-01

Food allergy offers numerous opportunities and challenges for the allergy and clinical immunology specialist. Physicians with board certification in allergy and clinical immunology should be the main source of reliable clinical information to educate patients with food-related disorders. There has been a wealth of reliable information published related to food allergy that can be utilized by health care providers in clinical practice. This includes information about the cross-reactivity of food allergens, the evaluation of potential new therapies, and the practical application of new diagnostic methods and management strategies. This article addresses some of the new developments in food allergy, with an emphasis on cross-reactvity of food allergens, recombinant food allergens, and potential future therapies for food allergy.

[Challenge prevention. From curative to preventive medicine-strategic and operational challenges].

PubMed

Schönermark, M P; Greif, K

2008-04-01

The potentials of preventive medicine to reduce the costs of illness have been inadequately exploited to date. Even if there is still massive dissent regarding the legal setup of a prevention law, prevention should play a significantly higher role in practice. Clinicians and practitioners could use preventive medicine as another differentiating factor in the increasingly competitive healthcare field. Prevention as a new strategic business segment allows a directed reaction to the demands of the payment system and opens up enormous value-added potential at the same time. Those who seize the chance to integrate prevention into their medical services portfolio and into the structure and processes of their respective hospitals will develop an important competitive advantage for the future.

New paradigms and future challenges in Radiation Oncology: An Update of Biological Targets and Technology*

PubMed Central

Liauw, Stanley L.; Connell, Philip P.; Weichselbaum, Ralph R.

2013-01-01

The primary objective of radiation oncology is to exploit the biological interaction of radiation within tissue to promote tumor death while minimizing damage to surrounding normal tissue. The clinical delivery of radiation relies on principles of radiation physics that define how radiation energy is deposited in the body, as well as technology that facilitates accurate tumor targeting. This review will summarize the current landscape of recent biological and technological advances in radiation oncology, describe the challenges that exist, and offer potential avenues for improvement. PMID:23427246

Global impacts of U.S. bioenergy production and policy: A general equilibrium perspective

NASA Astrophysics Data System (ADS)

Evans, Samuel Garner

The conversion of biomass to energy represents a promising pathway forward in efforts to reduce fossil fuel use in the transportation and electricity sectors. In addition to potential benefits, such as greenhouse gas reductions and increased energy security, bioenergy production also presents a unique set of challenges. These challenges include tradeoffs between food and fuel production, distortions in energy markets, and terrestrial emissions associated with changing land-use patterns. Each of these challenges arises from market-mediated responses to bioenergy production, and are therefore largely economic in nature. This dissertation directly addresses these opportunities and challenges by evaluating the economic impacts of U.S. bioenergy production and policy, focusing on both existing and future biomass-to-energy pathways. The analysis approaches the issue from a global, economy-wide perspective, reflecting two important facts. First, that large-scale bioenergy production connects multiple sectors of the economy due to the use of agricultural land resources for biomass production, and competition with fossil fuels in energy markets. Second, markets for both agricultural and energy commodities are highly integrated globally, causing domestic policies to have international effects. The reader can think of this work as being comprised of three parts. Part I provides context through an extensive review of the literature on the market-mediated effects of conventional biofuel production (Chapter 2) and develops a general equilibrium modeling framework for assessing the extent to which these phenomenon present a challenge for future bioenergy pathways (Chapter 3). Part II (Chapter 4) explores the economic impacts of the lignocellulosic biofuel production targets set in the U.S. Renewable Fuel Standard on global agricultural and energy commodity markets. Part III (Chapter 5) extends the analysis to consider potential inefficiencies associated with policy-induced competition for biomass between the electricity and transportation fuel sectors.

ATLAS and LHC computing on CRAY

NASA Astrophysics Data System (ADS)

Sciacca, F. G.; Haug, S.; ATLAS Collaboration

2017-10-01

Access and exploitation of large scale computing resources, such as those offered by general purpose HPC centres, is one important measure for ATLAS and the other Large Hadron Collider experiments in order to meet the challenge posed by the full exploitation of the future data within the constraints of flat budgets. We report on the effort of moving the Swiss WLCG T2 computing, serving ATLAS, CMS and LHCb, from a dedicated cluster to the large Cray systems at the Swiss National Supercomputing Centre CSCS. These systems do not only offer very efficient hardware, cooling and highly competent operators, but also have large backfill potentials due to size and multidisciplinary usage and potential gains due to economy at scale. Technical solutions, performance, expected return and future plans are discussed.

The gate studies: Assessing the potential of future small general aviation turbine engines

NASA Technical Reports Server (NTRS)

Strack, W. C.

1979-01-01

Four studies were completed that explore the opportunities for future General Aviation turbine engines (GATE) in the 150-1000 SHP class. These studies forecasted the potential impact of advanced technology turbine engines in the post-1988 market, identified important aircraft and missions, desirable engine sizes, engine performance, and cost goals. Parametric evaluations of various engine cycles, configurations, design features, and advanced technology elements defined baseline conceptual engines for each of the important missions identified by the market analysis. Both fixed-wing and helicopter aircraft, and turboshaft, turboprop, and turbofan engines were considered. Sizable performance gains (e.g., 20% SFC decrease), and large engine cost reductions of sufficient magnitude to challenge the reciprocating engine in the 300-500 SHP class were predicted.

Big data challenges for large radio arrays

NASA Astrophysics Data System (ADS)

Jones, D. L.; Wagstaff, K.; Thompson, D. R.; D'Addario, L.; Navarro, R.; Mattmann, C.; Majid, W.; Lazio, J.; Preston, J.; Rebbapragada, U.

2012-03-01

Future large radio astronomy arrays, particularly the Square Kilometre Array (SKA), will be able to generate data at rates far higher than can be analyzed or stored affordably with current practices. This is, by definition, a "big data" problem, and requires an end-to-end solution if future radio arrays are to reach their full scientific potential. Similar data processing, transport, storage, and management challenges face next-generation facilities in many other fields. The Jet Propulsion Laboratory is developing technologies to address big data issues, with an emphasis in three areas: 1) Lower-power digital processing architectures to make highvolume data generation operationally affordable, 2) Date-adaptive machine learning algorithms for real-time analysis (or "data triage") of large data volumes, and 3) Scalable data archive systems that allow efficient data mining and remote user code to run locally where the data are stored.

Medical education in Saudi Arabia: a review of recent developments and future challenges.

PubMed

Telmesani, A; Zaini, R G; Ghazi, H O

2011-08-01

Medical education has been changing rapidly in Saudi Arabia. Within a decade, the number of medical colleges increased from 5 medical schools with traditional disciplined-based curricula to 21 medical colleges with varied curricula ranging from the traditional to more innovative, problem-based, community-oriented programmes. The private sector has started investing in higher education generally and medical education in particular. Also other government sectors that provide advanced health services have started established new medical colleges. The expansion of quantity in medical education has been associated with a drive for greater quality assurance. Accreditation of higher education institutes began with the establishment of the National Commission for Academic Assessment and Accreditation in 2005. This review focuses on documenting developments in Saudi medical education up to 2008 and discussing the future potential and challenges facing the sector.

Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: Current knowledge and future implications.

PubMed

Nikitakis, Nikolaos G; Pentenero, Monica; Georgaki, Maria; Poh, Catherine F; Peterson, Douglas E; Edwards, Paul; Lingen, Mark; Sauk, John J

2018-06-01

Identification and management of potentially premalignant oral epithelial lesions (PPOELs) at highest risk of malignant transformation holds great promise for successful secondary prevention of oral squamous cell carcinoma, potentially reducing oral cancer morbidity and mortality. However, to date, neither clinical nor histopathologic validated risk predictors that can reliably predict which PPOELs will definitively progress to malignancy have been identified. In addition, the management of PPOELs remains a major challenge. Arguably, progress in the prevention and treatment of oral premalignancy and cancer will require improved understanding of the underlying molecular mechanisms, facilitating the discovery of diagnostic, prognostic, and predictive markers, as well as the identification of novel targeted therapeutics. This review provides a synopsis of the molecular biomarkers that have been studied in PPOELs and have been correlated with the presence and grade of dysplasia and/or their propensity to undergo malignant transformation to oral squamous cell carcinoma. The emphasis is on highlighting new emerging research fields, particularly epigenetic events, including methylation and micro-RNA regulation. Several promising biomarkers are highlighted. Current limitations and challenges are discussed. Recommendations for future focused research areas, to validate and promote clinically useful applications, are offered. Copyright © 2018 Elsevier Inc. All rights reserved.

Maximizing research study effectiveness in malaria elimination settings: a mixed methods study to capture the experiences of field-based staff.

PubMed

Canavati, Sara E; Quintero, Cesia E; Haller, Britt; Lek, Dysoley; Yok, Sovann; Richards, Jack S; Whittaker, Maxine Anne

2017-09-11

In a drug-resistant, malaria elimination setting like Western Cambodia, field research is essential for the development of novel anti-malarial regimens and the public health solutions necessary to monitor the spread of resistance and eliminate infection. Such field studies often face a variety of similar implementation challenges, but these are rarely captured in a systematic way or used to optimize future study designs that might overcome similar challenges. Field-based research staff often have extensive experience and can provide valuable insight regarding these issues, but their perspectives and experiences are rarely documented and seldom integrated into future research protocols. This mixed-methods analysis sought to gain an understanding of the daily challenges encountered by research field staff in the artemisinin-resistant, malaria elimination setting of Western Cambodia. In doing so, this study seeks to understand how the experiences and opinions of field staff can be captured, and used to inform future study designs. Twenty-two reports from six field-based malaria studies conducted in Western Cambodia were reviewed using content analysis to identify challenges to conducting the research. Informal Interviews, Focus Group Discussions and In-depth Interviews were also conducted among field research staff. Thematic analysis of the data was undertaken using Nvivo 9 ® software. Triangulation and critical case analysis was also used. There was a lack of formalized avenues through which field workers could report challenges experienced when conducting the malaria studies. Field research staff faced significant logistical barriers to participant recruitment and data collection, including a lack of available transportation to cover long distances, and the fact that mobile and migrant populations (MMPs) are usually excluded from studies because of challenges in follow-up. Cultural barriers to communication also hindered participant recruitment and created unexpected delays. Field staff often paid a physical, emotional and financial cost, going beyond their duty in order to keep the study running. Formal monthly reports filled out by field study staff could be a key tool for capturing field study staff experiences effectively, but require specific report fields to encourage staff to outline their challenges and to propose potential solutions. Forging strong bonds with communities and their leaders may improve communication, and decrease barriers to participant recruitment. Study designs that make it feasible for MMPs to participate should be pursued; in addition to increasing the potential participant pool, this will ensure that the most malaria-endemic demographic is taken into account in research studies. Overlaps between clinical care and research create ethical dilemmas for study staff, a fact that warrants careful consideration. Lessons learned from study field staff should be used to create a set of locally-relevant recommendations to inform future study designs.

Accelerating the Translation of Nanomaterials in Biomedicine

PubMed Central

Mitragotri, Samir; Anderson, Daniel G.; Chen, Xiaoyuan; Chow, Edward K.; Ho, Dean; Kabanov, Alexander V.; Karp, Jeffrey M.; Kataoka, Kazunori; Mirkin, Chad A.; Petrosko, Sarah Hurst; Shi, Jinjun; Stevens, Molly M.; Sun, Shouheng; Teoh, Sweehin; Venkatraman, Subbu S.; Xia, Younan; Wang, Shutao; Gu, Zhen; Xu, Chenjie

2017-01-01

Due to their size and tailorable physicochemical properties, nanomaterials are an emerging class of structures utilized in biomedical applications. There are now many prominent examples of nanomaterials being used to improve human health, in areas ranging from imaging and diagnostics to therapeutics and regenerative medicine. An overview of these examples reveals several common areas of synergy and future challenges. This Nano Focus discusses the current status and future potential of promising nanomaterials and their translation from the laboratory to the clinic, by highlighting a handful of successful examples. PMID:26115196

Psychiatric epidemiology: selected recent advances and future directions.

PubMed Central

Kessler, R. C.

2000-01-01

Reviewed in this article are selected recent advances and future challenges for psychiatric epidemiology. Major advances in descriptive psychiatric epidemiology in recent years include the development of reliable and valid fully structured diagnostic interviews, the implementation of parallel cross-national surveys of the prevalences and correlates of mental disorders, and the initiation of research in clinical epidemiology. Remaining challenges include the refinement of diagnostic categories and criteria, recognition and evaluation of systematic underreporting bias in surveys of mental disorders, creation and use of accurate assessment tools for studying disorders of children, adolescents, the elderly, and people in less developed countries, and setting up systems to carry out small area estimations for needs assessment and programme planning. Advances in analytical and experimental epidemiology have been more modest. A major challenge is for psychiatric epidemiologists to increase the relevance of their analytical research to their colleagues in preventative psychiatry as well as to social policy analysts. Another challenge is to develop interventions aimed at increasing the proportion of people with mental disorders who receive treatment. Despite encouraging advances, much work still needs to be conducted before psychiatric epidemiology can realize its potential to improve the mental health of populations. PMID:10885165

Physics, Physicists and Revolutionary Capabilities for the Intelligence Community

NASA Astrophysics Data System (ADS)

Porter, Lisa

2009-05-01

Over the past several decades, physicists have made seminal contributions to technological capabilities that have enabled the U.S. intelligence community to provide unexpected and unparalleled information to our nation's decision makers and help dispel the cloud of uncertainty they face in dealing with crises and challenges around the world. As we look to the future, we recognize that the ever-quickening pace of changes in the world and the threats we must confront demand continued innovation and improvement in the capabilities needed to provide the information on which our leaders depend. This talk will focus on some of the major technological challenges that the intelligence community faces in the coming years, and the many ways that physicists can help to overcome those challenges. The potential impact of physicists on the future capabilities of the US intelligence community is huge. In addition to the more obvious and direct impact through research in areas ranging from novel sensors to quantum information science, the unique approach physicists bring to a problem can also have an indirect but important effect by influencing how challenges in areas ranging from cybersecurity to advanced analytics are approached and solved. Several examples will be given.

Geoelectrical Tomography for landslide monitoring: state-of-the-art and future challenges.

NASA Astrophysics Data System (ADS)

Lapenna, V.; Perrone, A.; Piscitelli, S.

2011-12-01

Recently, novel algorithms for tomographic data inversion, robust models for describing the hydrogeophysical processes and new sensor networks for the field data acquisition have rapidly transformed the geoelectrical methods in a powerful and cost-effective tool for geo-hazard monitoring. These technological and methodological improvements disclose the way for a wide spectra of interesting and challenging applications in geo-hazards monitoring: reconstruction of landslide geometry; identification of fluid and gas uprising in volcanic areas; electrical imaging of seismic faults etc.. We briefly resume the current state-of-the-art of the geoelectrical methods in landslide monitoring and introduce new and emerging applications of the geoelectrical tomographic methods. An overview of the more interesting results obtained in different areas of Italian territory affected by wide and diffuse hydrogeological instability phenomena will be presented and discussed. We will focus the attention to some recent results obtained in the frame of national and international projects (Morfeo, Eurorisk/Preview, DORIS). One of the key challenges for the future will be the integration of active (Resistivity) and passive (Self-Potential) measurements for obtaining 2D, 3D and 4D (time-lapse) electrical tomographies able to follow the spatial and temporal dynamics of electrical parameters (i.e. resistivity, self-potential) inside the landslide body. The resistivity imaging can be applied for illuminating the sliding surfaces and for mapping the time-dependent changes of water content in vadose zones, while the Self Potential imaging could give a significant contribute for delineating the groundwater circulation patterns and to the early identification of triggering factors.

A tool to assess potential for alien plant establishment and expansion under climate change.

PubMed

Roger, Erin; Duursma, Daisy Englert; Downey, Paul O; Gallagher, Rachael V; Hughes, Lesley; Steel, Jackie; Johnson, Stephen B; Leishman, Michelle R

2015-08-15

Predicting the influence of climate change on the potential distribution of naturalised alien plant species is an important and challenging task. While prioritisation of management actions for alien plants under current climatic conditions has been widely adopted, very few systems explicitly incorporate the potential of future changes in climate conditions to influence the distribution of alien plant species. Here, we develop an Australia-wide screening tool to assess the potential of naturalised alien plants to establish and spread under both current and future climatic conditions. The screening tool developed uses five spatially explicit criteria to establish the likelihood of alien plant population establishment and expansion under baseline climate conditions and future climates for the decades 2035 and 2065. Alien plants are then given a threat rating according to current and future threat to enable natural resource managers to focus on those species that pose the largest potential threat now and in the future. To demonstrate the screening tool, we present results for a representative sample of approximately 10% (n = 292) of Australia's known, naturalised alien plant species. Overall, most alien plant species showed decreases in area of habitat suitability under future conditions compared to current conditions and therefore the threat rating of most alien plant species declined between current and future conditions. Use of the screening tool is intended to assist natural resource managers in assessing the threat of alien plant establishment and spread under current and future conditions and thus prioritise detailed weed risk assessments for those species that pose the greatest threat. The screening tool is associated with a searchable database for all 292 alien plant species across a range of spatial scales, available through an interactive web-based portal at http://weedfutures.net/. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Integrative data analysis in clinical psychology research.

PubMed

Hussong, Andrea M; Curran, Patrick J; Bauer, Daniel J

2013-01-01

Integrative data analysis (IDA), a novel framework for conducting the simultaneous analysis of raw data pooled from multiple studies, offers many advantages including economy (i.e., reuse of extant data), power (i.e., large combined sample sizes), the potential to address new questions not answerable by a single contributing study (e.g., combining longitudinal studies to cover a broader swath of the lifespan), and the opportunity to build a more cumulative science (i.e., examining the similarity of effects across studies and potential reasons for dissimilarities). There are also methodological challenges associated with IDA, including the need to account for sampling heterogeneity across studies, to develop commensurate measures across studies, and to account for multiple sources of study differences as they impact hypothesis testing. In this review, we outline potential solutions to these challenges and describe future avenues for developing IDA as a framework for studies in clinical psychology.

Integrative Data Analysis in Clinical Psychology Research

PubMed Central

Hussong, Andrea M.; Curran, Patrick J.; Bauer, Daniel J.

2013-01-01

Integrative Data Analysis (IDA), a novel framework for conducting the simultaneous analysis of raw data pooled from multiple studies, offers many advantages including economy (i.e., reuse of extant data), power (i.e., large combined sample sizes), the potential to address new questions not answerable by a single contributing study (e.g., combining longitudinal studies to cover a broader swath of the lifespan), and the opportunity to build a more cumulative science (i.e., examining the similarity of effects across studies and potential reasons for dissimilarities). There are also methodological challenges associated with IDA, including the need to account for sampling heterogeneity across studies, to develop commensurate measures across studies, and to account for multiple sources of study differences as they impact hypothesis testing. In this review, we outline potential solutions to these challenges and describe future avenues for developing IDA as a framework for studies in clinical psychology. PMID:23394226

Schistosomiasis elimination strategies and potential role of a vaccine in achieving global health goals.

PubMed

Mo, Annie X; Agosti, Jan M; Walson, Judd L; Hall, B Fenton; Gordon, Lance

2014-01-01

In March 2013, the National Institute of Allergy and Infectious Diseases and the Bill and Melinda Gates Foundation co-sponsored a meeting entitled "Schistosomiasis Elimination Strategy and Potential Role of a Vaccine in Achieving Global Health Goals" to discuss the potential role of schistosomiasis vaccines and other tools in the context of schistosomiasis control and elimination strategies. It was concluded that although schistosomiasis elimination in some focal areas may be achievable through current mass drug administration programs, global control and elimination will face several significant scientific and operational challenges, and will require an integrated approach with other, additional interventions. These challenges include vector (snail) control; environmental modification; water, sanitation, and hygiene; and other future innovative tools such as vaccines. Defining a clear product development plan that reflects a vaccine strategy as complementary to the existing control programs to combat different forms of schistosomiasis will be important to develop a vaccine effectively.

Delivery of Therapeutic Proteins Using Electrospun Fibers-Recent Developments and Current Challenges.

PubMed

Seif, Salem; Planz, Viktoria; Windbergs, Maike

2017-10-01

Proteins play a vital role within the human body by regulating various functions and even serving as structural constituent of many body parts. In this context, protein-based therapeutics have attracted a lot of attention in the last few decades as potential treatment of different diseases. Due to the steadily increasing interest in protein-based therapeutics, different dosage forms were investigated for delivering such complex macromolecules to the human body. Here, electrospun fibers hold a great potential for embedding proteins without structural damage and for controlled release of the protein for therapeutic applications. This review provides a comprehensive overview of the current state of protein-based carrier systems using electrospun fibers, with special emphasis on discussing their potential and key challenges in developing such therapeutic strategies, along with a prospective view of anticipated future directions. © 2017 Deutsche Pharmazeutische Gesellschaft.

Roadmap on quantum optical systems

NASA Astrophysics Data System (ADS)

Dumke, Rainer; Lu, Zehuang; Close, John; Robins, Nick; Weis, Antoine; Mukherjee, Manas; Birkl, Gerhard; Hufnagel, Christoph; Amico, Luigi; Boshier, Malcolm G.; Dieckmann, Kai; Li, Wenhui; Killian, Thomas C.

2016-09-01

This roadmap bundles fast developing topics in experimental optical quantum sciences, addressing current challenges as well as potential advances in future research. We have focused on three main areas: quantum assisted high precision measurements, quantum information/simulation, and quantum gases. Quantum assisted high precision measurements are discussed in the first three sections, which review optical clocks, atom interferometry, and optical magnetometry. These fields are already successfully utilized in various applied areas. We will discuss approaches to extend this impact even further. In the quantum information/simulation section, we start with the traditionally successful employed systems based on neutral atoms and ions. In addition the marvelous demonstrations of systems suitable for quantum information is not progressing, unsolved challenges remain and will be discussed. We will also review, as an alternative approach, the utilization of hybrid quantum systems based on superconducting quantum devices and ultracold atoms. Novel developments in atomtronics promise unique access in exploring solid-state systems with ultracold gases and are investigated in depth. The sections discussing the continuously fast-developing quantum gases include a review on dipolar heteronuclear diatomic gases, Rydberg gases, and ultracold plasma. Overall, we have accomplished a roadmap of selected areas undergoing rapid progress in quantum optics, highlighting current advances and future challenges. These exciting developments and vast advances will shape the field of quantum optics in the future.

Exploring Bim for Operational Integrated Asset Management - a Preliminary Study Utilising Real-World Infrastructure Data

NASA Astrophysics Data System (ADS)

Boyes, G. A.; Ellul, C.; Irwin, D.

2017-10-01

The use of 3D information models within collaborative working environments and the practice of Building Information Modelling (BIM) are becoming more commonplace within infrastructure projects. Currently used predominantly during the design and construction phase, the use of BIM is capable in theory of providing the information at handover that will satisfy the Asset Information Requirements (AIRs) of the future Infrastructure Manager (IM). One particular challenge is establishing a link between existing construction-centric information and the asset-centric information needed for future operations. Crossrail, a project to build a new high-frequency railway underneath London, is handling many such challenges as they prepare to handover their digital information to the future operator, in particular the need to provide a two-way link between a federated 3D CAD model and an object-relational Asset Information Management System (AIMS). This paper focusses on the potential for improved Asset Management (AM) by integrating BIM and GIS systems and practices, and makes a preliminary report on how 3D spatial queries can be used to establish a two-way relational link between two information systems (3D geometry and asset lists), as well as the challenges being overcome to transform the data to be suitable for AM.

Present Challenges, Critical Needs, and Future Technological Directions for NASA's GN and C Engineering Discipline

NASA Technical Reports Server (NTRS)

Dennehy, Cornelius J.

2010-01-01

The National Aeronautics and Space Administration (NASA) is currently undergoing a substantial redirection. Notable among the changes occurring within NASA is the stated emphasis on technology development, integration, and demonstration. These new changes within the Agency should have a positive impact on the GN&C discipline given the potential for sizeable investments for technology development and in-space demonstrations of both Autonomous Rendezvous & Docking (AR&D) systems and Autonomous Precision Landing (APL) systems. In this paper the NASA Technical Fellow for Guidance, Navigation and Control (GN&C) provides a summary of the present technical challenges, critical needs, and future technological directions for NASA s GN&C engineering discipline. A brief overview of the changes occurring within NASA that are driving a renewed emphasis on technology development will be presented as background. The potential benefits of the planned GN&C technology developments will be highlighted. This paper will provide a GN&C State-of-the-Discipline assessment. The discipline s readiness to support the goals & objectives of each of the four NASA Mission Directorates is evaluated and the technical challenges and barriers currently faced by the discipline are summarized. This paper will also discuss the need for sustained investments to sufficiently mature the several classes of GN&C technologies required to implement NASA crewed exploration and robotic science missions.

Integrated Approach of Agri-nanotechnology: Challenges and Future Trends

PubMed Central

Mishra, Sandhya; Keswani, Chetan; Abhilash, P. C.; Fraceto, Leonardo F.; Singh, Harikesh Bahadur

2017-01-01

Nanotechnology representing a new frontier in modern agriculture is anticipated to become a major thrust in near future by offering potential applications. This integrating approach, i.e., agri-nanotechnology has great potential to cope with global challenges of food production/security, sustainability and climate change. However, despite the potential benefits of nanotechnology in agriculture so far, their relevance has not reached up to the field conditions. The elevating concerns about fate, transport, bioavailability, nanoparticles toxicity and inappropriateness of regulatory framework limit the complete acceptance and inclination to adopt nanotechnologies in agricultural sector. Moreover, the current research trends lack realistic approach that fail to attain comprehensive knowledge of risk assessment factors and further toxicity of nanoparticles toward agroecosystem components viz. plant, soil, soil microbiomes after their release into the environment. Hence in the present review we attempt to suggest certain key points to be addressed in the current and future agri-nanotechnology researches on the basis of recognized knowledge gaps with strong recommendation of incorporating biosynthesized nanoparticles to carry out analogous functions. In this perspective, the major points are as follows: (i) Mitigating risk assessment factors (responsible for fate, transport, behavior, bioavailability and toxicity) for alleviating the subsequent toxicity of nanoparticles. (ii) Optimizing permissible level of nanoparticles dose within the safety limits by performing dose dependent studies. (iii) Adopting realistic approach by designing the experiments in natural habitat and avoiding in vitro assays for accurate interpretation. (iv) Most importantly, translating environmental friendly and non-toxic biosynthesized nanoparticles from laboratory to field conditions for agricultural benefits. PMID:28421100

Clearing up the Table: Food Pedagogies and Environmental Education--Contributions, Challenges and Future Agendas

ERIC Educational Resources Information Center

Swan, Elaine; Flowers, Rick

2015-01-01

In our paper, we draw on recent scholarship on food pedagogies and pedagogy studies to explore themes in the collection of articles in this special issue. In particular, we show how the articles variously conceptualise formal and informal pedagogies, their curricula, aims, and potential effects in relation to food and sustainability. Drawing on…

Exploiting LCSH, LCC, and DDC To Retrieve Networked Resources: Issues and Challenges.

ERIC Educational Resources Information Center

Chan, Lois Mai

This paper examines how the nature of the World Wide Web and characteristics of networked resources affect subject access and analyzes the requirements of effective indexing and retrieval tools. The current and potential uses of existing tools and possible courses of future development are explored in the context of recent research. The first…

Business-School Cooperatives: Meeting Educational Needs. Bar/School Partnership Programs Series.

ERIC Educational Resources Information Center

Taylor, Elenor

Business-school cooperatives are a potential solution to the need of students and educators to learn more about business, its functions in U.S. society, and the need of businesses to have a future workforce ready to face the challenges of an increasingly more complicated and highly technical work atmosphere. Such cooperatives, which are an…

Evaluating the sources of potential migrant species: implications under climate change

Treesearch

Ines Ibanez; James S. Clark; Michael C. Dietze

2008-01-01

As changes in climate become more apparent, ecologists face the challenge of predicting species responses to the new conditions. Most forecasts are based on climate envelopes (CE), correlative approaches that project future distributions on the basis of the current climate often assuming some dispersal lag. One major caveat with this approach is that it ignores the...

SEURAT: Safety Evaluation Ultimately Replacing Animal Testing – Recommendations for future research in the field of predictive toxicology

EPA Science Inventory

The development of non-animal methodology to evaluate the potential for a chemical to cause systemic toxicity is one of the grand challenges of modern science. The European research programme SEURAT is active in this field and will conclude its first phase, SEURAT-1, in December ...

Wildland fire management policy: Learning from the past and present and responding to future challenges

Treesearch

Tom Zimmerman

2009-01-01

Since its origin as a defined functional activity, wildland fire management has been the natural resource management program with the highest risk, complexity, and greatest potential for serious negative outcomes. During this time, this program has continually grown in temporal and spatial extent, operational complexity, ecological significance, social, economic, and...

U.S. Offshore Wind Manufacturing and Supply Chain Development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hamilton, Bruce

2013-02-22

This report seeks to provide an organized, analytical approach to identifying and bounding uncertainties around offshore wind manufacturing and supply chain capabilities; projecting potential component-level supply chain needs under three demand scenarios; and identifying key supply chain challenges and opportunities facing the future U.S. market and current suppliers of the nation’s landbased wind market.

A review of the challenges and opportunities in estimating above ground forest biomass using tree-level models

Treesearch

Hailemariam Temesgen; David Affleck; Krishna Poudel; Andrew Gray; John Sessions

2015-01-01

Accurate biomass measurements and analyses are critical components in quantifying carbon stocks and sequestration rates, assessing potential impacts due to climate change, locating bio-energy processing plants, and mapping and planning fuel treatments. To this end, biomass equations will remain a key component of future carbon measurements and estimation. As...

NASA-OAST program in photovoltaic energy conversion

NASA Technical Reports Server (NTRS)

Mullin, J. P.; Flood, D. J.

1982-01-01

The NASA program in photovoltaic energy conversion includes research and technology development efforts on solar cells, blankets, and arrays. The overall objectives are to increase conversion efficiency, reduce mass, reduce cost, and increase operating life. The potential growth of space power requirements in the future presents a major challenge to the current state of technology in space photovoltaic systems.

Adult Literacy Education: Current and Future Directions. An Update. Information Series No. 355.

ERIC Educational Resources Information Center

Fingeret, Hanna Arlene

A great deal of attention has been focused on adult literacy by policy makers, employers, unions, and state and federal government. An increasing body of work is challenging conventional assumptions and values related to literacy. The National Literacy Act of 1991 has the potential to develop an essential long-term infrastructure. Some basic…

Helper-Dependent Adenoviral Vectors.

PubMed

Rosewell, Amanda; Vetrini, Francesco; Ng, Philip

2011-10-29

Helper-dependent adenoviral vectors are devoid of all viral coding sequences, possess a large cloning capacity, and can efficiently transduce a wide variety of cell types from various species independent of the cell cycle to mediate long-term transgene expression without chronic toxicity. These non-integrating vectors hold tremendous potential for a variety of gene transfer and gene therapy applications. Here, we review the production technologies, applications, obstacles to clinical translation and their potential resolutions, and the future challenges and unanswered questions regarding this promising gene transfer technology.

Helper-Dependent Adenoviral Vectors

PubMed Central

Rosewell, Amanda; Vetrini, Francesco; Ng, Philip

2012-01-01

Helper-dependent adenoviral vectors are devoid of all viral coding sequences, possess a large cloning capacity, and can efficiently transduce a wide variety of cell types from various species independent of the cell cycle to mediate long-term transgene expression without chronic toxicity. These non-integrating vectors hold tremendous potential for a variety of gene transfer and gene therapy applications. Here, we review the production technologies, applications, obstacles to clinical translation and their potential resolutions, and the future challenges and unanswered questions regarding this promising gene transfer technology. PMID:24533227

Leader-Member Exchange Relationships in Health Information Management

PubMed Central

Hunt, T.J.

2014-01-01

This article seeks to raise awareness of the leader-member exchange (LMX) theory of leadership and its potential benefit to the health information management (HIM) profession. A literature review that was conducted identified a leadership challenge for HIM practitioners. The review also provides examples of leadership definitions, and potential benefits of LMX to HIM professionals in leading people and influencing leaders in their organizations. The LMX concept may be an avenue to investigate in preparing future and current HIM professionals for leadership. PMID:24808805

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rios-Torres, Jackeline; Malikopoulos, Andreas A.

Connected and automated vehicles (CAVs) have the potential to improve safety by reducing and mitigating traffic accidents. They can also provide opportunities to reduce transportation energy consumption and emissions by improving traffic flow. Vehicle communication with traffic structures and traffic lights can allow individual vehicles to optimize their operation and account for unpredictable changes. This paper summarizes the developments and the research trends in coordination with the CAVs that have been reported in the literature to date. In conclusion, remaining challenges and potential future research directions are also discussed.

Leader-member exchange relationships in health information management.

PubMed

Hunt, T J

2014-01-01

This article seeks to raise awareness of the leader-member exchange (LMX) theory of leadership and its potential benefit to the health information management (HIM) profession. A literature review that was conducted identified a leadership challenge for HIM practitioners. The review also provides examples of leadership definitions, and potential benefits of LMX to HIM professionals in leading people and influencing leaders in their organizations. The LMX concept may be an avenue to investigate in preparing future and current HIM professionals for leadership.

Domestication and Breeding of Tomatoes: What have We Gained and What Can We Gain in the Future?

PubMed Central

Bai, Yuling; Lindhout, Pim

2007-01-01

Background It has been shown that a large variation is present and exploitable from wild Solanum species but most of it is still untapped. Considering the thousands of Solanum accessions in different gene banks and probably even more that are still untouched in the Andes, it is a challenge to exploit the diversity of tomato. What have we gained from tomato domestication and breeding and what can we gain in the future? Scope This review summarizes progress on tomato domestication and breeding and current efforts in tomato genome research. Also, it points out potential challenges in exploiting tomato biodiversity and depicts future perspectives in tomato breeding with the emerging knowledge from tomato-omics. Conclusions From first domestication to modern breeding, the tomato has been continually subjected to human selection for a wide array of applications in both science and commerce. Current efforts in tomato breeding are focused on discovering and exploiting genes for the most important traits in tomato germplasm. In the future, breeders will design cultivars by a process named ‘breeding by design’ based on the combination of science and technologies from the genomic era as well as their practical skills. PMID:17717024

Midwifery: "at the edge of history".

PubMed

Dahlen, H

2006-03-01

The paper focuses on possible future pathways in maternity care for midwives and nations to consider. The paper blends personal and professional experiences to outline priority areas facing midwives in the future. It begins by examining maternal mortality and morbidity in the developing world and considering the potential of the ten high priority action messages (1997) in helping to improve the plight of women and children in the future. The paper then examines major issues facing midwives in the developed world including: the way birth is viewed; the medical-midwifery divide; marketing midwifery; and finally the challenge of dealing with fear around birth. The third part of the paper examines a part of society where the two worlds meet and there are issues from both the developed and developing world to consider. The paper focuses on women from culturally and linguistically diverse communities, Aboriginal and Torres Strait Islander women and women birthing in remote and rural areas. By looking at these three worlds separately the paper examines different concerns facing midwives in the future but also draws on common issues that face us all as citizens of this planet and particularly as predominantly women. The paper challenges midwives to be politically active and dare to change the world.

Economic benefits of supersonic overland operation

NASA Technical Reports Server (NTRS)

Metwally, Munir

1992-01-01

Environmental concerns are likely to impose some restrictions on the next generation of supersonic commercial transport. There is a global concern over the effects of engine emissions on the ozone layer which protects life on Earth from ultraviolet radiation. There is also some concern over community noise. The High Speed Civil Transport (HSCT) must meet at least the current subsonic noise certification standards to be compatible with the future subsonic fleet. Concerns over sonic boom represent another environmental and marketing challenge to the HSCT program. The most attractive feature of the supersonic transport is speed, which offers the traveling public significant time-savings on long range routes. The sonic boom issue represents a major environmental and economic challenge as well. Supersonic operation overland produces the most desirable economic results. However, unacceptable overland sonic boom raise levels may force HSCT to use subsonic speeds overland. These environmental and economic challenges are likely to impose some restrictions on supersonic operation, thus introducing major changes to existing route structures and future supersonic network composition. The current subsonic route structure may have to be altered for supersonic transports to avoid sensitive areas in the stratosphere or to minimize overland flight tracks. It is important to examine the alternative route structure and the impact of these restrictions on the economic viability of the overall supersonic operation. Future market potential for HSCT fleets must be large enough to enable engine and airframe manufacturers to build the plane at a cost that provides them with an attractive return on investment and to sell it at a price that allows the airlines to operate with a reasonable margin of profit. Subsonic overland operation of a supersonic aircraft hinders its economic viability. Ways to increase the market potential of supersonic operation are described.

The gut microbiome as a target for prevention and treatment of hyperglycaemia in type 2 diabetes: from current human evidence to future possibilities.

PubMed

Brunkwall, Louise; Orho-Melander, Marju

2017-06-01

The totality of microbial genomes in the gut exceeds the size of the human genome, having around 500-fold more genes that importantly complement our coding potential. Microbial genes are essential for key metabolic processes, such as the breakdown of indigestible dietary fibres to short-chain fatty acids, biosynthesis of amino acids and vitamins, and production of neurotransmitters and hormones. During the last decade, evidence has accumulated to support a role for gut microbiota (analysed from faecal samples) in glycaemic control and type 2 diabetes. Mechanistic studies in mice support a causal role for gut microbiota in metabolic diseases, although human data favouring causality is insufficient. As it may be challenging to sort the human evidence from the large number of animal studies in the field, there is a need to provide a review of human studies. Thus, the aim of this review is to cover the current and future possibilities and challenges of using the gut microbiota, with its capacity to be modified, in the development of preventive and treatment strategies for hyperglycaemia and type 2 diabetes in humans. We discuss what is known about the composition and functionality of human gut microbiota in type 2 diabetes and summarise recent evidence of current treatment strategies that involve, or are based on, modification of gut microbiota (diet, probiotics, metformin and bariatric surgery). We go on to review some potential future gut-based glucose-lowering approaches involving microbiota, including the development of personalised nutrition and probiotic approaches, identification of therapeutic components of probiotics, targeted delivery of propionate in the proximal colon, targeted delivery of metformin in the lower gut, faecal microbiota transplantation, and the incorporation of genetically modified bacteria that express therapeutic factors into microbiota. Finally, future avenues and challenges for understanding the interplay between human nutrition, genetics and microbial genetics, and the need for integration of human multi-omic data (such as genetics, transcriptomics, epigenetics, proteomics and metabolomics) with microbiome data (such as strain-level variation, transcriptomics, proteomics and metabolomics) to make personalised treatments a successful future reality are discussed.

Integrating horizon scanning and strategic risk prioritisation using a weight of evidence framework to inform policy decisions.

PubMed

Garnett, K; Lickorish, F A; Rocks, S A; Prpich, G; Rathe, A A; Pollard, S J T

2016-08-01

Poor connection between data on emerging issues and credible policy decisions continues to challenge governments, and is only likely to grow as demands on time and resources increase. Here we summarise recent efforts to integrate horizon scanning and risk prioritisation approaches to better connect emerging issues to the political discourse on environmental and food-related issues. Our categorisation of insights including potential future risks and opportunities to inform policy discussions has emerged from a structured three-year programme of horizon scanning for a UK pan-governmental futures partnership led by the Department for Environment, Food and Rural Affairs (Defra). Our efforts to integrate horizon scanning and risk prioritisation, utilising a qualitative weight of evidence framework, has created a systematic process for identifying all signals of potential future change with significant impact for the strategic mission and underlying values of policy actors. Our approach encourages an exploration of factors out of the control of organisations, recognising that resilience depends on the flexibility of management strategies and the preparedness to deal with a variety of unexpected outcomes. We discuss how this approach addresses key cultural and evaluative challenges that policy actors have had in embedding horizon scanning in evidence-based policy processes, and suggest further developments to build confidence in the use of horizon scanning for strategic planning. Copyright © 2016 Elsevier B.V. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bunch, Kyle J.; Williams, Laura S.; Jones, Anthony M.

The 2010 ratification of the New START Treaty has been widely regarded as a noteworthy national security achievement for both the Obama administration and the Medvedev-Putin regime, but deeper cuts are envisioned under future arms control regimes. Future verification needs will include monitoring the storage of warhead components and fissile materials and verifying dismantlement of warheads, pits, secondaries, and other materials. From both the diplomatic and technical perspectives, verification under future arms control regimes will pose new challenges. Since acceptable verification technology must protect sensitive design information and attributes, non-nuclear non-sensitive signatures may provide a significant verification tool without themore » use of additional information barriers. The use of electromagnetic signatures to monitor nuclear material storage containers is a promising technology with the potential to fulfill these challenging requirements. Research performed at Pacific Northwest National Laboratory (PNNL) has demonstrated that low frequency electromagnetic signatures of sealed metallic containers can be used to confirm the presence of specific components on a “yes/no” basis without revealing classified information. Arms control inspectors might use this technique to verify the presence or absence of monitored items, including both nuclear and non-nuclear materials. Although additional research is needed to study signature aspects such as uniqueness and investigate container-specific scenarios, the technique potentially offers a rapid and cost-effective tool to verify reduction and dismantlement of U.S. and Russian nuclear weapons.« less

Perspectives on the Future of CFD

NASA Technical Reports Server (NTRS)

Kwak, Dochan

2000-01-01

This viewgraph presentation gives an overview of the future of computational fluid dynamics (CFD), which in the past has pioneered the field of flow simulation. Over time CFD has progressed as computing power. Numerical methods have been advanced as CPU and memory capacity increases. Complex configurations are routinely computed now and direct numerical simulations (DNS) and large eddy simulations (LES) are used to study turbulence. As the computing resources changed to parallel and distributed platforms, computer science aspects such as scalability (algorithmic and implementation) and portability and transparent codings have advanced. Examples of potential future (or current) challenges include risk assessment, limitations of the heuristic model, and the development of CFD and information technology (IT) tools.

It’s about time: How do sky surveys manage uncertainty about scientific needs many years into the future

NASA Astrophysics Data System (ADS)

Darch, Peter T.; Sands, Ashley E.

2016-06-01

Sky surveys, such as the Sloan Digital Sky Survey (SDSS) and the Large Synoptic Survey Telescope (LSST), generate data on an unprecedented scale. While many scientific projects span a few years from conception to completion, sky surveys are typically on the scale of decades. This paper focuses on critical challenges arising from long timescales, and how sky surveys address these challenges.We present findings from a study of LSST, comprising interviews (n=58) and observation. Conceived in the 1990s, the LSST Corporation was formed in 2003, and construction began in 2014. LSST will commence data collection operations in 2022 for ten years.One challenge arising from this long timescale is uncertainty about future needs of the astronomers who will use these data many years hence. Sources of uncertainty include scientific questions to be posed, astronomical phenomena to be studied, and tools and practices these astronomers will have at their disposal. These uncertainties are magnified by the rapid technological and scientific developments anticipated between now and the start of LSST operations.LSST is implementing a range of strategies to address these challenges. Some strategies involve delaying resolution of uncertainty, placing this resolution in the hands of future data users. Other strategies aim to reduce uncertainty by shaping astronomers’ data analysis practices so that these practices will integrate well with LSST once operations begin.One approach that exemplifies both types of strategy is the decision to make LSST data management software open source, even now as it is being developed. This policy will enable future data users to adapt this software to evolving needs. In addition, LSST intends for astronomers to start using this software well in advance of 2022, thereby embedding LSST software and data analysis approaches in the practices of astronomers.These findings strengthen arguments for making the software supporting sky surveys available as open source. Such arguments usually focus on reuse potential of software, and enhancing replicability of analyses. In this case, however, open source software also promises to mitigate the critical challenge of anticipating the needs of future data users.

Traditional Chinese medicine: potential approaches from modern dynamical complexity theories.

PubMed

Ma, Yan; Zhou, Kehua; Fan, Jing; Sun, Shuchen

2016-03-01

Despite the widespread use of traditional Chinese medicine (TCM) in clinical settings, proving its effectiveness via scientific trials is still a challenge. TCM views the human body as a complex dynamical system, and focuses on the balance of the human body, both internally and with its external environment. Such fundamental concepts require investigations using system-level quantification approaches, which are beyond conventional reductionism. Only methods that quantify dynamical complexity can bring new insights into the evaluation of TCM. In a previous article, we briefly introduced the potential value of Multiscale Entropy (MSE) analysis in TCM. This article aims to explain the existing challenges in TCM quantification, to introduce the consistency of dynamical complexity theories and TCM theories, and to inspire future system-level research on health and disease.

The Asteroid Impact and Deflection Assessment Mission and its Potential Contributions to Human Exploration of Asteroids

NASA Technical Reports Server (NTRS)

Abell, Paul A.; Rivkin, Andy S.

2014-01-01

The joint ESA and NASA Asteroid Impact and Deflection Assessment (AIDA) mission will directly address aspects of NASA's Asteroid Initiative and will contribute to future human exploration. The NASA Asteroid Initiative is comprised of two major components: the Grand Challenge and the Asteroid Mission. The first component, the Grand Challenge, focuses on protecting Earth's population from asteroid impacts by detecting potentially hazardous objects with enough warning time to either prevent them from impacting the planet, or to implement civil defense procedures. The Asteroid Mission, involves sending astronauts to study and sample a near-Earth asteroid (NEA) prior to conducting exploration missions of the Martian system, which includes Phobos and Deimos. AIDA's primary objective is to demonstrate a kinetic impact deflection and characterize the binary NEA Didymos. The science and technical data obtained from AIDA will aid in the planning of future human exploration missions to NEAs and other small bodies. The dual robotic missions of AIDA, ESA's Asteroid Impact Monitor (AIM) and NASA's Double Asteroid Redirection Test (DART), will provide a great deal of technical and engineering data on spacecraft operations for future human space exploration while conducting in-depth scientific examinations of the binary target Didymos both prior to and after the kinetic impact demonstration. The knowledge gained from this mission will help identify asteroidal physical properties in order to maximize operational efficiency and reduce mission risk for future small body missions. The AIDA data will help fill crucial strategic knowledge gaps concerning asteroid physical characteristics that are relevant for human exploration considerations at similar small body destinations.

Microbial Cellulases and Their Industrial Applications

PubMed Central

Kuhad, Ramesh Chander; Gupta, Rishi; Singh, Ajay

2011-01-01

Microbial cellulases have shown their potential application in various industries including pulp and paper, textile, laundry, biofuel production, food and feed industry, brewing, and agriculture. Due to the complexity of enzyme system and immense industrial potential, cellulases have been a potential candidate for research by both the academic and industrial research groups. Nowadays, significant attentions have been devoted to the current knowledge of cellulase production and the challenges in cellulase research especially in the direction of improving the process economics of various industries. Scientific and technological developments and the future prospects for application of cellulases in different industries are discussed in this paper. PMID:21912738

New challenges in propagation research in the US

NASA Technical Reports Server (NTRS)

Davarian, Faramaz

1993-01-01

Earth/space propagation research in the U.S. is tied to new developments in satellite communications. In spite of the fiber optics competition for trunked point-to-point communications, a host of emerging services are discovering the great potential of satellites for wireless communications. The application of satellites for radio communications appears to grow with a rapid pace in the areas of thin-route and mobile/personal communications. An important factor influencing the future of satellite communications is the congestion of the spectral slots at Ku- and lower bands. This heavy usage of the spectrum gives rise to conflicts among the users and consequently forces regulatory organizations to relocate frequency assignments, a decision that, for obvious reasons, is unpopular with the relocated service. Because of this frequency shortage, frequencies in Ka- and higher spectral bands are currently viewed as good candidates for Earth/space communications in the future. Therefore, new challenges in propagation research in the U.S. include the characterization of mobile/personal links and the investigation of higher bands for satellite communications. The plans and the challenges of the propagation research in the U.S. are briefly reviewed.

Engineering stem cells for future medicine.

PubMed

Ricotti, Leonardo; Menciassi, Arianna

2013-03-01

Despite their great potential in regenerative medicine applications, stem cells (especially pluripotent ones) currently show a limited clinical success, partly due to a lack of biological knowledge, but also due to a lack of specific and advanced technological instruments able to overcome the current boundaries of stem cell functional maturation and safe/effective therapeutic delivery. This paper aims at describing recent insights, current limitations, and future horizons related to therapeutic stem cells, by analyzing the potential of different bioengineering disciplines in bringing stem cells toward a safe clinical use. First, we clarify how and why stem cells should be properly engineered and which could be in a near future the challenges and the benefits connected with this process. Second, we identify different routes toward stem cell differentiation and functional maturation, relying on chemical, mechanical, topographical, and direct/indirect physical stimulation. Third, we highlight how multiscale modeling could strongly support and optimize stem cell engineering. Finally, we focus on future robotic tools that could provide an added value to the extent of translating basic biological knowledge into clinical applications, by developing ad hoc enabling technologies for stem cell delivery and control.

Potential and challenges of zeolite chemistry in the catalytic conversion of biomass.

PubMed

Ennaert, Thijs; Van Aelst, Joost; Dijkmans, Jan; De Clercq, Rik; Schutyser, Wouter; Dusselier, Michiel; Verboekend, Danny; Sels, Bert F

2016-02-07

Increasing demand for sustainable chemicals and fuels has pushed academia and industry to search for alternative feedstocks replacing crude oil in traditional refineries. As a result, an immense academic attention has focused on the valorisation of biomass (components) and derived intermediates to generate valuable platform chemicals and fuels. Zeolite catalysis plays a distinct role in many of these biomass conversion routes. This contribution emphasizes the progress and potential in zeolite catalysed biomass conversions and relates these to concepts established in existing petrochemical processes. The application of zeolites, equipped with a variety of active sites, in Brønsted acid, Lewis acid, or multifunctional catalysed reactions is discussed and generalised to provide a comprehensive overview. In addition, the feedstock shift from crude oil to biomass involves new challenges in developing fields, like mesoporosity and pore interconnectivity of zeolites and stability of zeolites in liquid phase. Finally, the future challenges and perspectives of zeolites in the processing of biomass conversion are discussed.

Metal–Air Batteries: Will They Be the Future Electrochemical Energy Storage Device of Choice? [Metal-Air Batteries: Future Electrochemical Energy Storage of Choice?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Yanguang; Lu, Jun

Metal-air batteries have much higher theoretical energy density than lithium-ion batteries, and are frequently advocated as the solution toward next-generation electrochemical energy storage for applications including electric vehicles or grid energy storage. Yet they have not fulfilled their full potentials as limited by challenges associated with the metal anode, air cathode and electrolyte. These challenges would have to be properly resolved before metal-air batteries can become a practical reality and be deployed on a large scale. Here we survey the current status and latest advances in metal-air battery research for both aqueous (e.g. Zn-air) and non-aqueous (e.g. Li-air) systems. Themore » general technical issues confronting their developments are overviewed, and our perspective on possible solutions is offered.« less

Seal Technology for Hypersonic Vehicle and Propulsion: An Overview

NASA Technical Reports Server (NTRS)

Steinetz, Bruce M.

2008-01-01

Hypersonic vehicles and propulsion systems pose an extraordinary challenge for structures and materials. Airframes and engines require lightweight, high-temperature materials and structural configurations that can withstand the extreme environment of hypersonic flight. Some of the challenges posed include very high temperatures, heating of the whole vehicle, steady-state and transient localized heating from shock waves, high aerodynamic loads, high fluctuating pressure loads, potential for severe flutter, vibration, and acoustic loads and erosion. Correspondingly high temperature seals are required to meet these aggressive requirements. This presentation reviews relevant seal technology for both heritage (e.g. Space Shuttle, X-15, and X-38) vehicles and presents several seal case studies aimed at providing lessons learned for future hypersonic vehicle seal development. This presentation also reviews seal technology developed for the National Aerospace Plane propulsion systems and presents several seal case studies aimed at providing lessons learned for future hypersonic propulsion seal development.

Metal–Air Batteries: Will They Be the Future Electrochemical Energy Storage Device of Choice? [Metal-Air Batteries: Future Electrochemical Energy Storage of Choice?

DOE PAGES

Li, Yanguang; Lu, Jun

2017-05-05

Metal-air batteries have much higher theoretical energy density than lithium-ion batteries, and are frequently advocated as the solution toward next-generation electrochemical energy storage for applications including electric vehicles or grid energy storage. Yet they have not fulfilled their full potentials as limited by challenges associated with the metal anode, air cathode and electrolyte. These challenges would have to be properly resolved before metal-air batteries can become a practical reality and be deployed on a large scale. Here we survey the current status and latest advances in metal-air battery research for both aqueous (e.g. Zn-air) and non-aqueous (e.g. Li-air) systems. Themore » general technical issues confronting their developments are overviewed, and our perspective on possible solutions is offered.« less

Damage prognosis: the future of structural health monitoring.

PubMed

Farrar, Charles R; Lieven, Nick A J

2007-02-15

This paper concludes the theme issue on structural health monitoring (SHM) by discussing the concept of damage prognosis (DP). DP attempts to forecast system performance by assessing the current damage state of the system (i.e. SHM), estimating the future loading environments for that system, and predicting through simulation and past experience the remaining useful life of the system. The successful development of a DP capability will require the further development and integration of many technology areas including both measurement/processing/telemetry hardware and a variety of deterministic and probabilistic predictive modelling capabilities, as well as the ability to quantify the uncertainty in these predictions. The multidisciplinary and challenging nature of the DP problem, its current embryonic state of development, and its tremendous potential for life-safety and economic benefits qualify DP as a 'grand challenge' problem for engineers in the twenty-first century.

Climate change, resource use and food security in midcentury under a range of plausible scenarios

NASA Astrophysics Data System (ADS)

Wiebe, K.

2016-12-01

Achieving and maintaining food security at local, national and global scales is challenged by changes in population, income and climate, among other socioeconomic and biophysical drivers. Assessing these challenges and possible solutions over the coming decades requires a systematic and multidisciplinary approach. The Global Futures and Strategic Foresight program, a CGIAR initiative led by the International Food Policy Research Institute in collaboration with the 14 other CGIAR research centers, is working to improve tools and conduct ex ante assessments of promising technologies, investments and policies under alternative global futures to inform decision making in the CGIAR and its partners. Alternative socioeconomic and climate scenarios are explored using an integrated system of climate, water, crop and economic models. This presentation will share findings from recent projections of food production and prices to 2050 at global and regional scales, together with their potential implications for land and water use, food security, nutrition and health.

The world's nuclear future - built on material success

NASA Astrophysics Data System (ADS)

Ion, Sue

2010-07-01

In our energy hungry world of the twenty-first century, the future of electricity generation must meet the twin challenges of security of supply and reduced carbon emissions. The expectations for nuclear power programmes to play a part in delivering success on both counts, grows ever higher. The nuclear industry is poised on a renaissance likely to dwarf the heady days of the 1960s and early 1970s. Global supply chain and project management challenges abound, now just as then. The science and engineering of materials will be key to the successful deployment and operation of a new generation of reactor systems and their associated fuel cycles. Understanding and predicting materials performance will be key to achieving life extension of existing assets and underpinning waste disposal options, as well as giving confidence to the designers, their financial backers and governments across the globe, that the next generation of reactors will deliver their full potential.

Supersonic Retropropulsion Technology Development in NASA's Entry, Descent, and Landing Project

NASA Technical Reports Server (NTRS)

Edquist, Karl T.; Berry, Scott A.; Rhode, Matthew N.; Kelb, Bil; Korzun, Ashley; Dyakonov, Artem A.; Zarchi, Kerry A.; Schauerhamer, Daniel G.; Post, Ethan A.

2012-01-01

NASA's Entry, Descent, and Landing (EDL) space technology roadmap calls for new technologies to achieve human exploration of Mars in the coming decades [1]. One of those technologies, termed Supersonic Retropropulsion (SRP), involves initiation of propulsive deceleration at supersonic Mach numbers. The potential benefits afforded by SRP to improve payload mass and landing precision make the technology attractive for future EDL missions. NASA's EDL project spent two years advancing the technological maturity of SRP for Mars exploration [2-15]. This paper summarizes the technical accomplishments from the project and highlights challenges and recommendations for future SRP technology development programs. These challenges include: developing sufficiently large SRP engines for use on human-scale entry systems; testing and computationally modelling complex and unsteady SRP fluid dynamics; understanding the effects of SRP on entry vehicle stability and controllability; and demonstrating sub-scale SRP entry systems in Earth's atmosphere.

The first GCC Marine Biotechnology Symposium: Emerging Opportunities and Future Perspectives.

PubMed

Goddard, Stephen; Delghandi, Madjid; Dobretsov, Sergey; Al-Oufi, Hamed; Al-Habsi, Saoud; Burgess, J Grant

2015-06-01

With its diverse, living marine resources and rapidly growing educational and research infrastructure, the Sultanate of Oman is well-positioned to take advantage of the commercial opportunities presented by marine biotechnology. In recognition of potential development, an international symposium, Marine Biotechnology-Emerging Opportunities and Future Perspectives, was held in Muscat, November 12-13, 2013. Three keynote addresses were given, 23 oral presentations made, and a poster exhibition held. The final session reviewed national and regional issues, and the delegates agreed informally on a number of future actions. The potential for future development of marine biotechnology was recognized by all delegates, and following the symposium, they were surveyed for their views on how best to sustain and develop new activities. One hundred percent of respondents found the meeting useful and would support future symposia in the region. Fifty-one percent of Omani respondents recognized major organizational challenges and obstacles to the development of marine biotechnology compared with 23 % of overseas respondents. The need for greater collaboration between research institutions within the GCC region was recognized by 98 % of all respondents. The presentations and survey outcomes are reviewed in this paper.

Future Directions in Tactical Vertical Lift

DTIC Science & Technology

2010-04-29

The Aviation Science and Technology Challenge • OSD Future Vertical Lift • Transition to the Future AGENDA UNCLASSIFIED UNCLASSIFIED 4 Yourfilename.ppt...distributed, non-contiguous operations Joint Future Operational Environment The S&T Challenge Increased reliance on force projection by Aviation...UNCLASSIFIED UNCLASSIFIED 7 Yourfilename.ppt The S&T Challenge • “Army Aviation is the service’s most requested asset around the globe, ….. some units

Qualitative research in rehabilitation science: opportunities, challenges, and future directions.

PubMed

VanderKaay, Sandra; Moll, Sandra E; Gewurtz, Rebecca E; Jindal, Pranay; Loyola-Sanchez, Adalberto; Packham, Tara L; Lim, Chun Y

2018-03-01

Qualitative research has had a significant impact within rehabilitation science over time. During the past 20 years the number of qualitative studies published per year in Disability and Rehabilitation has markedly increased (from 1 to 54). In addition, during this period there have been significant changes in how qualitative research is conceptualized, conducted, and utilized to advance the field of rehabilitation. The purpose of this article is to reflect upon the progress of qualitative research within rehabilitation to date, to explicate current opportunities and challenges, and to suggest future directions to continue to strengthen the contribution of qualitative research in this field. Relevant literature searches were conducted in electronic data bases and reference lists. Pertinent literature was examined to identify current opportunities and challenges for qualitative research use in rehabilitation and to identify future directions. Six key areas of opportunity and challenge were identified: (a) paradigm shifts, (b) advancements in methodology, (c) emerging technology, (d) advances in quality evaluation, (e) increasing popularity of mixed methods approaches, and (f) evolving approaches to knowledge translation. Two important future directions for rehabilitation are posited: (1) advanced training in qualitative methods and (2) engaging qualitative communities of research. Qualitative research is well established in rehabilitation and has an important place in the continued growth of this field. Ongoing development of qualitative researchers and methods are essential. Implications for Rehabilitation Qualitative research has the potential to improve rehabilitation practice by addressing some of the most pervasive concerns in the field such as practitioner-client interaction, the subjective and lived experience of disability, and clinical reasoning and decision making. This will serve to better inform those providing rehabilitation services thereby benefiting patients that are utilizing these services. Changes over time in how qualitative research is conceptualized, conducted, and utilized to advance rehabilitation science have resulted in a number of unique opportunities and challenges in using qualitative research that must be considered within this field. Advances in methodology and increased expectations for evaluation must be considered to ensure quality and credibility of qualitative rehabilitation research within rehabilitation. Improved quality and credibility may increase likelihood of research dissemination and use by clinicians intervening within the rehabilitation process in order to improve clinical practice. In order to maximize opportunities and mitigate challenges there are two principal future directions for rehabilitation scientists to consider: (1) advancing training in qualitative methods to adequately prepare future rehabilitation scientists and (2) engaging qualitative communities of research.

Polycystic ovary syndrome and adverse pregnancy outcomes: Current state of knowledge, challenges and potential implications for practice.

PubMed

Bahri Khomami, Mahnaz; Boyle, Jacqueline A; Tay, Chau T; Vanky, Eszter; Teede, Helena J; Joham, Anju E; Moran, Lisa J

2018-06-01

Although there is a growing body of literature reporting that pregnancies in women with polycystic ovary syndrome (PCOS) are associated with greater complications than those without PCOS, methodological differences across studies make these results difficult to consolidate. This narrative review outlines potential mechanisms involved in adverse pregnancy outcomes in PCOS and the nature of the complications. It covers limitations of current evidence and future research directions. Future research should include prospective studies with phenotypic stratification of PCOS and matching or consideration of specific PCOS manifestations and risk factors specific to each pregnancy complication. This review also emphasizes the importance of following a healthy lifestyle for women with PCOS and of individualized care according to overall risk factors for pregnancy complications. © 2018 John Wiley & Sons Ltd.

iPSCs-based anti-aging therapies: Recent discoveries and future challenges.

PubMed

Pareja-Galeano, Helios; Sanchis-Gomar, Fabián; Pérez, Laura M; Emanuele, Enzo; Lucia, Alejandro; Gálvez, Beatriz G; Gallardo, María Esther

2016-05-01

The main biological hallmarks of the aging process include stem cell exhaustion and cellular senescence. Consequently, research efforts to treat age-related diseases as well as anti-aging therapies in general have recently focused on potential 'reprogramming' regenerative therapies. These new approaches are based on induced pluripotent stem cells (iPSCs), including potential in vivo reprogramming for tissue repair. Another possibility is targeting pathways of cellular senescence, e.g., through modulation of p16INK4a signaling and especially inhibition of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Here, we reviewed and discussed these recent developments together with their possible usefulness for future treatments against sarcopenia, a major age-related condition. Copyright © 2016 Elsevier B.V. All rights reserved.

A see through future: augmented reality and health information systems.

PubMed

Monkman, Helen; Kushniruk, Andre W

2015-01-01

Augmented Reality (AR) is a method whereby virtual objects are superimposed on the real world. AR technology is becoming increasingly accessible and affordable and it has many potential health applications. This paper discusses current research on AR health applications such as medical education and medical practice. Some of the potential future uses for this technology (e.g., health information systems, consumer health applications) will also be presented. Additionally, there will be a discussion outlining some of usability and human factors challenges associated with AR in healthcare. It is expected that AR will become increasingly prevalent in healthcare; however, further investigation is required to demonstrate that they provide benefits over traditional methods. Moreover, AR applications must be thoroughly tested to ensure they do not introduce new errors into practice and have patient safety implications.

Accelerator physics and technology challenges of very high energy hadron colliders

NASA Astrophysics Data System (ADS)

Shiltsev, Vladimir D.

2015-08-01

High energy hadron colliders have been in the forefront of particle physics for more than three decades. At present, international particle physics community considers several options for a 100 TeV proton-proton collider as a possible post-LHC energy frontier facility. The method of colliding beams has not fully exhausted its potential but has slowed down considerably in its progress. This paper briefly reviews the accelerator physics and technology challenges of the future very high energy colliders and outlines the areas of required research and development towards their technical and financial feasibility.

Potential and challenges of the physics measurements with very forward detectors at linear colliders

NASA Astrophysics Data System (ADS)

Božović Jelisavčić, Ivanka; Kačarević, G.; Lukić, S.; Poss, S.; Sailer, A.; Smiljanić, I.; FCAL Collaboration

2016-04-01

The instrumentation of the very forward region of a detector at a future linear collider (ILC, CLIC) is briefly reviewed. The status of the FCAL R&D activity is given with emphasis on physics and technological challenges. The current status of studies on absolute luminosity measurement, luminosity spectrum reconstruction and high-energy electron identification with the forward calorimeters is given. The impact of FCAL measurements on physics studies is illustrated with an example of the σHWW ṡBR (H →μ+μ-) measurement at 1.4 TeV CLIC.

Accelerator physics and technology challenges of very high energy hadron colliders

DOE PAGES

Shiltsev, Vladimir D.

2015-08-20

High energy hadron colliders have been in the forefront of particle physics for more than three decades. At present, international particle physics community considers several options for a 100 TeV proton–proton collider as a possible post-LHC energy frontier facility. The method of colliding beams has not fully exhausted its potential but has slowed down considerably in its progress. This article briefly reviews the accelerator physics and technology challenges of the future very high energy colliders and outlines the areas of required research and development towards their technical and financial feasibility.

Precision gas therapy using intelligent nanomedicine.

PubMed

He, Qianjun

2017-10-24

Gas therapy is an emerging and promising field, utilizing the unique therapeutic effects of several kinds of gases (NO, CO, H 2 S and H 2 ) towards many major diseases, including cancer and cardiovascular diseases, and it is also facing challenges relating to enhancing gas therapy efficacy and avoiding gas poisoning risks. Here, we have proposed a new concept for precision gas therapy using a nanomedicine strategy to overcome the challenges. In this perspective, we have addressed a series of existing and potential solutions from the point of view of nanomedicine, and conveyed a collection of opinions about future expandable research into precision gas therapy.

Assessing and Managing the Current and Future Pest Risk from Water Hyacinth, (Eichhornia crassipes), an Invasive Aquatic Plant Threatening the Environment and Water Security.

PubMed

Kriticos, Darren J; Brunel, Sarah

2016-01-01

Understanding and managing the biological invasion threats posed by aquatic plants under current and future climates is a growing challenge for biosecurity and land management agencies worldwide. Eichhornia crassipes is one of the world's worst aquatic weeds. Presently, it threatens aquatic ecosystems, and hinders the management and delivery of freshwater services in both developed and developing parts of the world. A niche model was fitted using CLIMEX, to estimate the potential distribution of E. crassipes under historical and future climate scenarios. Under two future greenhouse gas emission scenarios for 2080 simulated with three Global Climate Models, the area with a favourable temperature regime appears set to shift polewards. The greatest potential for future range expansion lies in Europe. Elsewhere in the northern hemisphere temperature gradients are too steep for significant geographical range expansion under the climate scenarios explored here. In the Southern Hemisphere, the southern range boundary for E. crassipes is set to expand southwards in Argentina, Australia and New Zealand; under current climate conditions it is already able to invade the southern limits of Africa. The opportunity exists to prevent its spread into the islands of Tasmania in Australia and the South Island of New Zealand, both of which depend upon hydroelectric facilities that would be threatened by the presence of E. crassipes. In Europe, efforts to slow or stop the spread of E. crassipes will face the challenge of limited internal biosecurity capacity. The modelling technique demonstrated here is the first application of niche modelling for an aquatic weed under historical and projected future climates. It provides biosecurity agencies with a spatial tool to foresee and manage the emerging invasion threats in a manner that can be included in the international standard for pest risk assessments. It should also support more detailed local and regional management.

Assessing and Managing the Current and Future Pest Risk from Water Hyacinth, (Eichhornia crassipes), an Invasive Aquatic Plant Threatening the Environment and Water Security

PubMed Central

Brunel, Sarah

2016-01-01

Understanding and managing the biological invasion threats posed by aquatic plants under current and future climates is a growing challenge for biosecurity and land management agencies worldwide. Eichhornia crassipes is one of the world’s worst aquatic weeds. Presently, it threatens aquatic ecosystems, and hinders the management and delivery of freshwater services in both developed and developing parts of the world. A niche model was fitted using CLIMEX, to estimate the potential distribution of E. crassipes under historical and future climate scenarios. Under two future greenhouse gas emission scenarios for 2080 simulated with three Global Climate Models, the area with a favourable temperature regime appears set to shift polewards. The greatest potential for future range expansion lies in Europe. Elsewhere in the northern hemisphere temperature gradients are too steep for significant geographical range expansion under the climate scenarios explored here. In the Southern Hemisphere, the southern range boundary for E. crassipes is set to expand southwards in Argentina, Australia and New Zealand; under current climate conditions it is already able to invade the southern limits of Africa. The opportunity exists to prevent its spread into the islands of Tasmania in Australia and the South Island of New Zealand, both of which depend upon hydroelectric facilities that would be threatened by the presence of E. crassipes. In Europe, efforts to slow or stop the spread of E. crassipes will face the challenge of limited internal biosecurity capacity. The modelling technique demonstrated here is the first application of niche modelling for an aquatic weed under historical and projected future climates. It provides biosecurity agencies with a spatial tool to foresee and manage the emerging invasion threats in a manner that can be included in the international standard for pest risk assessments. It should also support more detailed local and regional management. PMID:27513336

The challenge of modelling and mapping the future distribution and impact of invasive alien species

Treesearch

Robert C. Venette

2015-01-01

Invasions from alien species can jeopardize the economic, environmental or social benefits derived from biological systems. Biosecurity measures seek to protect those systems from accidental or intentional introductions of species that might become injurious. Pest risk maps convey how the probability of invasion by an alien species or the potential consequences of that...

Exploring the Role of Future Perspective in Predicting Turkish University Students' Beliefs about Global Climate Change

ERIC Educational Resources Information Center

Ates, Deniz; Teksöz, Gaye; Ertepinar, Hamide

2017-01-01

Recent studies indicate that limited understanding about causes and its potential impacts of climate change and fault beliefs by people across different countries of the world including Turkey is a real challenge. Acceptance of climate change as a real threat, believing its existence, and knowing causes and consequences are very significant for…

Learners' Ensemble Based Security Conceptual Model for M-Learning System in Malaysian Higher Learning Institution

ERIC Educational Resources Information Center

Mahalingam, Sheila; Abdollah, Faizal Mohd; Sahib, Shahrin

2014-01-01

M-Learning has a potential to improve efficiency in the education sector and has a tendency to grow advance and transform the learning environment in the future. Yet there are challenges in many areas faced when introducing and implementing m-learning. The learner centered attribute in mobile learning implies deployment in untrustworthy learning…

Mobile Learning in Higher Education: An Empirical Assessment of a New Educational Tool

ERIC Educational Resources Information Center

McConatha, Douglas; Praul, Matt; Lynch, Michael J.

2008-01-01

Mobile Learning, or M-learning as it is often called, is a relatively new tool in the pedagogical arsenal to assist students and teachers as they navigate the options available in the expanding distance learning world. This article assesses some of the possible methods, challenges and future potential of using this approach in a college classroom…

Opportunities and Challenges for Building Alumni Networks in Sweden: A Case Study of Stockholm University

ERIC Educational Resources Information Center

Ebert, Karin; Axelsson, Leona; Harbor, Jon

2015-01-01

Because of the potential value of alumni involvement for student success, for connections to society and as a base for future philanthropy, there is growing interest in developing university alumni relations programmes in countries that do not have a long tradition in this area. This case study of Stockholm University describes the goals,…

The national fire and fire surrogate study: early results and future challenges

Treesearch

Thomas A. Waldrop; James McIver

2006-01-01

Fire-adapted ecosystems today have dense plant cover and heavy fuel loads as a result of fire exclusion and other changes in land use practices. Mechanical fuel treatments and prescribed fire are powerful tools for reducing wildfire potential, but the ecological consequences of their use is unknown. The National Fire and Fire Surrogate Study examines the effects of...

Time-Resolved Diffuse Optical Spectroscopy and Imaging Using Solid-State Detectors: Characteristics, Present Status, and Research Challenges

PubMed Central

Alayed, Mrwan

2017-01-01

Diffuse optical spectroscopy (DOS) and diffuse optical imaging (DOI) are emerging non-invasive imaging modalities that have wide spread potential applications in many fields, particularly for structural and functional imaging in medicine. In this article, we review time-resolved diffuse optical imaging (TR-DOI) systems using solid-state detectors with a special focus on Single-Photon Avalanche Diodes (SPADs) and Silicon Photomultipliers (SiPMs). These TR-DOI systems can be categorized into two types based on the operation mode of the detector (free-running or time-gated). For the TR-DOI prototypes, the physical concepts, main components, figures-of-merit of detectors, and evaluation parameters are described. The performance of TR-DOI prototypes is evaluated according to the parameters used in common protocols to test DOI systems particularly basic instrumental performance (BIP). In addition, the potential features of SPADs and SiPMs to improve TR-DOI systems and expand their applications in the foreseeable future are discussed. Lastly, research challenges and future developments for TR-DOI are discussed for each component in the prototype separately and also for the entire system. PMID:28906462

Microsurgery robots: addressing the needs of high-precision surgical interventions.

PubMed

Mattos, Leonardo S; Caldwell, Darwin G; Peretti, Giorgio; Mora, Francesco; Guastini, Luca; Cingolani, Roberto

2016-01-01

Robotics has a significant potential to enhance the overall capacity and efficiency of healthcare systems. Robots can help surgeons perform better quality operations, leading to reductions in the hospitalisation time of patients and in the impact of surgery on their postoperative quality of life. In particular, robotics can have a significant impact on microsurgery, which presents stringent requirements for superhuman precision and control of the surgical tools. Microsurgery is, in fact, expected to gain importance in a growing range of surgical specialties as novel technologies progressively enable the detection, diagnosis and treatment of diseases at earlier stages. Within such scenarios, robotic microsurgery emerges as one of the key components of future surgical interventions, and will be a vital technology for addressing major surgical challenges. Nonetheless, several issues have yet to be overcome in terms of mechatronics, perception and surgeon-robot interfaces before microsurgical robots can achieve their full potential in operating rooms. Research in this direction is progressing quickly and microsurgery robot prototypes are gradually demonstrating significant clinical benefits in challenging applications such as reconstructive plastic surgery, ophthalmology, otology and laryngology. These are reassuring results offering confidence in a brighter future for high-precision surgical interventions.

Becoming Earth Independent: Human-Automation-Robotics Integration Challenges for Future Space Exploration

NASA Technical Reports Server (NTRS)

Marquez, Jessica J.

2016-01-01

Future exploration missions will require NASA to integrate more automation and robotics in order to accomplish mission objectives. This presentation will describe on the future challenges facing the human operator (astronaut, ground controllers) as we increase the amount of automation and robotics in spaceflight operations. It will describe how future exploration missions will have to adapt and evolve in order to deal with more complex missions and communication latencies. This presentation will outline future human-automation-robotic integration challenges.

The connectomics challenge

PubMed Central

Silvestri, Ludovico; Sacconi, Leonardo; Pavone, Francesco Saverio

Summary One of the most fascinating challenges in neuroscience is the reconstruction of the connectivity map of the brain. Recent years have seen a rapid expansion in the field of connectomics, whose aim is to trace this map and understand its relationship with neural computation. Many different approaches, ranging from electron and optical microscopy to magnetic resonance imaging, have been proposed to address the connectomics challenge on various spatial scales and in different species. Here, we review the main technological advances in the microscopy techniques applied to connectomics, highlighting the potential and limitations of the different methods. Finally, we briefly discuss the role of connectomics in the Human Brain Project, the Future and Emerging Technologies (FET) Flagship recently approved by the European Commission. PMID:24139653

Pathway analyses and understanding disease associations

PubMed Central

Liu, Yu; Chance, Mark R

2013-01-01

High throughput technologies have been applied to investigate the underlying mechanisms of complex diseases, identify disease-associations and help to improve treatment. However it is challenging to derive biological insight from conventional single gene based analysis of “omics” data from high throughput experiments due to sample and patient heterogeneity. To address these challenges, many novel pathway and network based approaches were developed to integrate various “omics” data, such as gene expression, copy number alteration, Genome Wide Association Studies, and interaction data. This review will cover recent methodological developments in pathway analysis for the detection of dysregulated interactions and disease-associated subnetworks, prioritization of candidate disease genes, and disease classifications. For each application, we will also discuss the associated challenges and potential future directions. PMID:24319650

Small bowel obstruction and the gastrografin challenge.

PubMed

D'Agostino, Robert; Ali, Naiim S; Leshchinskiy, Sergey; Cherukuri, Anjuli R; Tam, Judy K

2018-04-09

The "gastrografin challenge" has been used for decades in the evaluation of small bowel obstruction (SBO). This type of study involves enteric administration of a water-soluble contrast followed by serial abdominal radiographs. While its diagnostic role is well established, its therapeutic role remains controversial. Following an algorithm for gastrografin challenge cases can help with interpretation. An understanding of the appearance of diluted contrast in the small bowel, the concentrating effect of contrast in the colon, and knowledge of surgical history and anatomy is paramount for diagnosis. In this article, we review the approach to acute SBO and the use of gastrografin along with reviewing image interpretation of cases of partial and complete SBO. Gastrografin use in adynamic ileus along with other potential future uses is also discussed.

Projected climate and vegetation changes and potential biotic effects for Fort Benning, Georgia; Fort Hood, Texas; and Fort Irwin, California

USGS Publications Warehouse

Shafer, S.L.; Atkins, J.; Bancroft, B.A.; Bartlein, P.J.; Lawler, J.J.; Smith, B.; Wilsey, C.B.

2012-01-01

The responses of species and ecosystems to future climate changes will present challenges for conservation and natural resource managers attempting to maintain both species populations and essential habitat. This report describes projected future changes in climate and vegetation for three study areas surrounding the military installations of Fort Benning, Georgia, Fort Hood, Texas, and Fort Irwin, California. Projected climate changes are described for the time period 2070–2099 (30-year mean) as compared to 1961–1990 (30-year mean) for each study area using data simulated by the coupled atmosphere-ocean general circulation models CCSM3, CGCM3.1(T47), and UKMO-HadCM3, run under the B1, A1B, and A2 future greenhouse gas emissions scenarios. These climate data are used to simulate potential changes in important components of the vegetation for each study area using LPJ, a dynamic global vegetation model, and LPJ-GUESS, a dynamic vegetation model optimized for regional studies. The simulated vegetation results are compared with observed vegetation data for the study areas. Potential effects of the simulated future climate and vegetation changes for species and habitats of management concern are discussed in each study area, with a particular focus on federally listed threatened and endangered species.

Vision for Micro Technology Space Missions. Chapter 2

NASA Technical Reports Server (NTRS)

Dennehy, Neil

2005-01-01

It is exciting to contemplate the various space mission applications that Micro Electro Mechanical Systems (MEMS) technology could enable in the next 10-20 years. The primary objective of this chapter is to both stimulate ideas for MEMS technology infusion on future NASA space missions and to spur adoption of the MEMS technology in the minds of mission designers. This chapter is also intended to inform non-space oriented MEMS technologists, researchers and decision makers about the rich potential application set that future NASA Science and Exploration missions will provide. The motivation for this chapter is therefore to lead the reader down a path to identify and it is exciting to contemplate the various space mission applications that Micro Electro Mechanical Systems (MEMS) technology could enable in the next 10-20 years. The primary objective of this chapter is to both stimulate ideas for MEMS technology infusion on future NASA space missions and to spur adoption of the MEMS technology in the minds of mission designers. This chapter is also intended to inform non-space oriented MEMS technologists, researchers and decision makers about the rich potential application set that future NASA Science and Exploration missions will provide. The motivation for this chapter is therefore to lead the reader down a path to identify and consider potential long-term, perhaps disruptive or revolutionary, impacts that MEMS technology may have for future civilian space applications. A general discussion of the potential for MEMS in space applications is followed by a brief showcasing of a few selected examples of recent MEMS technology developments for future space missions. Using these recent developments as a point of departure, a vision is then presented of several areas where MEMS technology might eventually be exploited in future Science and Exploration mission applications. Lastly, as a stimulus for future research and development, this chapter summarizes a set of barriers to progress, design challenges and key issues that must be overcome in order for the community to move on, from the current nascent phase of developing and infusing MEMS technology into space missions, in order to achieve its full future potential.

The EuPA Biobank Initiative: Meeting the future challenges of biobanking in proteomics & systems medicine.

PubMed

Wheelock, Åsa M; Paulson, Linda; Litton, Jan-Eric

2015-09-08

In this News & Reviews Discussion, the recently launched EuPA (European Proteomics Association) Biobank Initiative is introduced in the context of current and future challenges in biobanking. The purpose of the initiative is to provide a forumand knowledge platform for integrating the extensive experiences collected by the EuPA community, and link it to the European and international biobanking communities at large. The specific impact of providing a forum and easy access to this type of information to the EuPA community is the potential of improving the quality of future sample collections and biobanks, the quality of the research produced from these sample collections, as well as the output and productivity from existing biobanks. The underutilization of biobanks has recently been identified as an emerging issue of biobankingworldwide. Measures to improve our ability to locate and access appropriate sample collections for a wide range of research purposes may enhance both the scientific quality and biobank sustainability, thereby contributing to the important task of moving our research beyond basic findings and mere publications, into clinical practice. This manuscript is intended as a Discussion piece, and represents a recollection of the presentation under the “EuPA Initiative” session at HUPO/EuPA 2014 in Madrid. The launch of the EuPA (European Proteomics Association) Biobank Initiative in the context of current and future challenges in biobanking is discussed. The purpose of the initiative is to provide a forum and knowledge base for integrating the extensive experiences collected by the EuPA community, and link it to the European and international biobanking communities at large. The specific impact of providing a forumand easy access to this type of information to the EuPA community is the potential of improving the quality of future sample collections and biobanks, the quality of the research produced from these sample collections, aswell as the output and productivity fromexisting biobanks. The underutilization of biobanks has recently been identified as a challenge to the well-being and economic sustainability of biobanking worldwide. Measures to improve our ability to localize and access appropriate sample collections for validation studies and other research purposes is thus of benefit bothto scientific quality and biobank sustainability, thereby contributing to the important task of moving our research beyond basic findings and mere publications, into clinical practice. This article is part of a Special Issue entitled: HUPO 2014.

Prospective use of unmanned aerial vehicles for military medical evacuation in future conflicts.

PubMed

Handford, Charles; Reeves, F; Parker, P

2018-03-09

In order to continue to deliver outstanding medical care on the battlefield, the UK Defence Medical Services must continue to adapt, overcome and actively embrace change. One potential area is the rapid proliferation and sophistication of automated and remote systems such as unmanned aerial vehicles (UAVs). UAVs are already used to deliver blood to remote military locations in Afghanistan and defibrillators to those that need them in the USA and Sweden. An area of future opportunity would be to facilitate rapid evacuation of wounded personnel from high intensity, high threat, remote and austere areas directly to specialist care. Such a capability would reduce threat to human life while allowing rapid extraction of casualties from high risk or inaccessible environments straight back to Role 3 care, all of which in these situations is either not possible or carries too much risk using conventional aerial assets. The article aims to highlight a potential future capability, stimulate debate and reflection, all of which is essential for innovation and future organisational development. The potential uses and benefits of UAVs are highlighted including both the challenges and rewards of utilising UAVs for casualty evacuation. Key benefits are reduced risk to human life, cost, ability to insert into areas conventional aircraft cannot and the rapidity of transfer. Challenges are likely to be airspace management, decisions on appropriate level of care to deliver during transit and ultimately user acceptability. The article also highlights that in order to maximise our ability to exploit new technologies, all arms and trades within the military must be involved in collective research and development. Furthermore, sensible corroboration with private companies will further enhance our ability to acquire products that best serve our needs. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Next generation sequencing in clinical medicine: Challenges and lessons for pathology and biomedical informatics.

PubMed

Gullapalli, Rama R; Desai, Ketaki V; Santana-Santos, Lucas; Kant, Jeffrey A; Becich, Michael J

2012-01-01

The Human Genome Project (HGP) provided the initial draft of mankind's DNA sequence in 2001. The HGP was produced by 23 collaborating laboratories using Sanger sequencing of mapped regions as well as shotgun sequencing techniques in a process that occupied 13 years at a cost of ~$3 billion. Today, Next Generation Sequencing (NGS) techniques represent the next phase in the evolution of DNA sequencing technology at dramatically reduced cost compared to traditional Sanger sequencing. A single laboratory today can sequence the entire human genome in a few days for a few thousand dollars in reagents and staff time. Routine whole exome or even whole genome sequencing of clinical patients is well within the realm of affordability for many academic institutions across the country. This paper reviews current sequencing technology methods and upcoming advancements in sequencing technology as well as challenges associated with data generation, data manipulation and data storage. Implementation of routine NGS data in cancer genomics is discussed along with potential pitfalls in the interpretation of the NGS data. The overarching importance of bioinformatics in the clinical implementation of NGS is emphasized.[7] We also review the issue of physician education which also is an important consideration for the successful implementation of NGS in the clinical workplace. NGS technologies represent a golden opportunity for the next generation of pathologists to be at the leading edge of the personalized medicine approaches coming our way. Often under-emphasized issues of data access and control as well as potential ethical implications of whole genome NGS sequencing are also discussed. Despite some challenges, it's hard not to be optimistic about the future of personalized genome sequencing and its potential impact on patient care and the advancement of knowledge of human biology and disease in the near future.

Next generation sequencing in clinical medicine: Challenges and lessons for pathology and biomedical informatics

PubMed Central

Gullapalli, Rama R.; Desai, Ketaki V.; Santana-Santos, Lucas; Kant, Jeffrey A.; Becich, Michael J.

2012-01-01

The Human Genome Project (HGP) provided the initial draft of mankind's DNA sequence in 2001. The HGP was produced by 23 collaborating laboratories using Sanger sequencing of mapped regions as well as shotgun sequencing techniques in a process that occupied 13 years at a cost of ~$3 billion. Today, Next Generation Sequencing (NGS) techniques represent the next phase in the evolution of DNA sequencing technology at dramatically reduced cost compared to traditional Sanger sequencing. A single laboratory today can sequence the entire human genome in a few days for a few thousand dollars in reagents and staff time. Routine whole exome or even whole genome sequencing of clinical patients is well within the realm of affordability for many academic institutions across the country. This paper reviews current sequencing technology methods and upcoming advancements in sequencing technology as well as challenges associated with data generation, data manipulation and data storage. Implementation of routine NGS data in cancer genomics is discussed along with potential pitfalls in the interpretation of the NGS data. The overarching importance of bioinformatics in the clinical implementation of NGS is emphasized.[7] We also review the issue of physician education which also is an important consideration for the successful implementation of NGS in the clinical workplace. NGS technologies represent a golden opportunity for the next generation of pathologists to be at the leading edge of the personalized medicine approaches coming our way. Often under-emphasized issues of data access and control as well as potential ethical implications of whole genome NGS sequencing are also discussed. Despite some challenges, it's hard not to be optimistic about the future of personalized genome sequencing and its potential impact on patient care and the advancement of knowledge of human biology and disease in the near future. PMID:23248761

Engineering photosynthetic organisms for the production of biohydrogen

DOE PAGES

Dubini, Alexandra; Ghirardi, Maria L.

2014-03-27

Oxygenic photosynthetic organisms such as green algae are capable of absorbing sunlight and converting the chemical energy into hydrogen gas. This process takes advantage of the photosynthetic apparatus of these organisms which links water oxidation to H 2 production. Biological H 2 has therefore the potential to be an alternative fuel of the future and shows great promise for generating large scale sustainable energy. Microalgae are able to produce H 2 under light anoxic or dark anoxic condition by activating 3 different pathways that utilize the hydrogenases as catalysts. In this review, we highlight the principal barriers that prevent hydrogenmore » production in green algae and how those limitations are being addressed, through metabolic and genetic engineering. We also discuss the major challenges and bottlenecks facing the development of future commercial algal photobiological systems for H 2 production. Lastly we provide suggestions for future strategies and potential new techniques to be developed towards an integrated system with optimized hydrogen production.« less

The Challenges of Plasma Material Interactions in Nuclear Fusion Devices and Potential Solutions

DOE PAGES

Rapp, J.

2017-07-12

Plasma Material Interactions in future fusion reactors have been identified as a knowledge gap to be dealt with before any next step device past ITER can be built. The challenges are manifold. They are related to power dissipation so that the heat fluxes to the plasma facing components can be kept at technologically feasible levels; maximization of the lifetime of divertor plasma facing components that allow for steady-state operation in a reactor to reach the neutron fluences required; the tritium inventory (storage) in the plasma facing components, which can lead to potential safety concerns and reduction in the fuel efficiency;more » and it is related to the technology of the plasma facing components itself, which should demonstrate structural integrity under the high temperatures and neutron fluence. This contribution will give an overview and summary of those challenges together with some discussion of potential solutions. New linear plasma devices are needed to investigate the PMI under fusion reactor conditions and test novel plasma facing components. The Material Plasma Exposure eXperiment MPEX will be introduced and a status of the current R&D towards MPEX will be summarized.« less

The Challenges of Plasma Material Interactions in Nuclear Fusion Devices and Potential Solutions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rapp, J.

Plasma Material Interactions in future fusion reactors have been identified as a knowledge gap to be dealt with before any next step device past ITER can be built. The challenges are manifold. They are related to power dissipation so that the heat fluxes to the plasma facing components can be kept at technologically feasible levels; maximization of the lifetime of divertor plasma facing components that allow for steady-state operation in a reactor to reach the neutron fluences required; the tritium inventory (storage) in the plasma facing components, which can lead to potential safety concerns and reduction in the fuel efficiency;more » and it is related to the technology of the plasma facing components itself, which should demonstrate structural integrity under the high temperatures and neutron fluence. This contribution will give an overview and summary of those challenges together with some discussion of potential solutions. New linear plasma devices are needed to investigate the PMI under fusion reactor conditions and test novel plasma facing components. The Material Plasma Exposure eXperiment MPEX will be introduced and a status of the current R&D towards MPEX will be summarized.« less

Modelling Bambara Groundnut Yield in Southern Africa: Towards a Climate-Resilient Future

NASA Technical Reports Server (NTRS)

Karunaratne, A. S.; Walker, S.; Ruane, A. C.

2015-01-01

Current agriculture depends on a few major species grown as monocultures that are supported by global research underpinning current productivity. However, many hundreds of alternative crops have the potential to meet real world challenges by sustaining humanity, diversifying agricultural systems for food and nutritional security, and especially responding to climate change through their resilience to certain climate conditions. Bambara groundnut (Vigna subterranea (L.) Verdc.), an underutilised African legume, is an exemplar crop for climate resilience. Predicted yield performances of Bambara groundnut by AquaCrop (a crop-water productivity model) were evaluated for baseline (1980-2009) and mid-century climates (2040-2069) under 20 downscaled Global Climate Models (CMIP5-RCP8.5), as well as for climate sensitivities (AgMIPC3MP) across 3 locations in Southern Africa (Botswana, South Africa, Namibia). Different land - races of Bambara groundnut originating from various semi-arid African locations showed diverse yield performances with diverse sensitivities to climate. S19 originating from hot-dry conditions in Namibia has greater future yield potential compared to the Swaziland landrace Uniswa Red-UN across study sites. South Africa has the lowest yield under the current climate, indicating positive future yield trends. Namibia reported the highest baseline yield at optimum current temperatures, indicating less yield potential in future climates. Bambara groundnut shows positive yield potential at temperatures of up to 31degC, with further warming pushing yields down. Thus, many regions in Southern Africa can utilize Bambara groundnut successfully in the coming decades. This modelling exercise supports decisions on genotypic suitability for present and future climates at specific locations.

Imaging hadron calorimetry for future Lepton Colliders

NASA Astrophysics Data System (ADS)

Repond, José

2013-12-01

To fully exploit the physics potential of a future Lepton Collider requires detectors with unprecedented jet energy and dijet-mass resolution. To meet these challenges, detectors optimized for the application of Particle Flow Algorithms (PFAs) are being designed and developed. The application of PFAs, in turn, requires calorimeters with very fine segmentation of the readout, so-called imaging calorimeters. This talk reviews progress in imaging hadron calorimetry as it is being developed for implementation in a detector at a future Lepton Collider. Recent results from the large prototypes built by the CALICE Collaboration, such as the Scintillator Analog Hadron Calorimeter (AHCAL) and the Digital Hadron Calorimeters (DHCAL and SDHCAL) are being presented. In addition, various R&D efforts beyond the present prototypes are being discussed.

Comments for A Conference on Verification in the 21st Century

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doyle, James E.

2012-06-12

The author offers 5 points for the discussion of Verification and Technology: (1) Experience with the implementation of arms limitation and arms reduction agreements confirms that technology alone has never been relied upon to provide effective verification. (2) The historical practice of verification of arms control treaties between Cold War rivals may constrain the cooperative and innovative use of technology for transparency, veification and confidence building in the future. (3) An area that has been identified by many, including the US State Department and NNSA as being rich for exploration for potential uses of technology for transparency and verification ismore » information and communications technology (ICT). This includes social media, crowd-sourcing, the internet of things, and the concept of societal verification, but there are issues. (4) On the issue of the extent to which verification technologies are keeping pace with the demands of future protocols and agrements I think the more direct question is ''are they effective in supporting the objectives of the treaty or agreement?'' In this regard it is important to acknowledge that there is a verification grand challenge at our doorstep. That is ''how does one verify limitations on nuclear warheads in national stockpiles?'' (5) Finally, while recognizing the daunting political and security challenges of such an approach, multilateral engagement and cooperation at the conceptual and technical levels provides benefits for addressing future verification challenges.« less

Introduction to the supplement.

PubMed

Rappuoli, Rino

2015-06-08

In July of 2014, a symposium entitled "Enhancing Vaccine Immunity and Value" was held in Siena, Italy. The focus of the symposium was on how to best meet the challenge of developing and implementing vaccines for future disease targets. Vaccination has been responsible for averting estimated 3 billion cases of disease and more than 500 million lives to date through the prevention of infectious diseases. This has largely been responsible for dramatic increases in life span in developed countries. However, with the demographics of the world's population are changing, with many adults now surviving into their 80s, we now face the challenge of protecting the aging and other underserved populations not only against infectious diseases but also against cancer and other chronic conditions that occur in older adults. To face this challenge, we must harness new technologies derived from recent advances in the fields of immunology, structural biology, synthetic biology and genomics that promise a revolution in the vaccine field. Specifically, vaccine adjuvants have the potential to harness the immune system to provide protection against new types of diseases, improve protection in young children and expand this protection to adults and the elderly. However, in order to succeed, we need to overcome the non-technical challenges that could limit the implementation of innovative vaccines, including controversies regarding the safety of adjuvants, increasing regulatory complexity, the inadequate methods used to assess the value of novel vaccines, and the resulting industry alienation from future investment. In this supplement, we have assembled manuscripts from lectures and discussions of the symposium last July that addressed two related questions: how to improve vaccine efficacy using breakthrough technologies and how to capture the full potential of novel vaccines. Copyright © 2015 Elsevier Ltd. All rights reserved.

Future Mission Trends and their Implications for the Deep Space Network

NASA Technical Reports Server (NTRS)

Abraham, Douglas S.

2006-01-01

Planning for the upgrade and/or replacement of Deep Space Network (DSN) assets that typically operate for forty or more years necessitates understanding potential customer needs as far into the future as possible. This paper describes the methodology Deep Space Network (DSN) planners use to develop this understanding, some key future mission trends that have emerged from application of this methodology, and the implications of the trends for the DSN's future evolution. For NASA's current plans out to 2030, these trends suggest the need to accommodate: three times as many communication links, downlink rates two orders of magnitude greater than today's, uplink rates some four orders of magnitude greater, and end-to-end link difficulties two-to-three orders of magnitude greater. To meet these challenges, both DSN capacity and capability will need to increase.

The IAU’s involvement in the Astronomy and World Heritage Initiative: achievements and challenges

NASA Astrophysics Data System (ADS)

Ruggles, Clive L. N.

2015-08-01

Since 2008 the IAU has worked with UNESCO and its advisory bodies to help recognise, promote and protect all types of astronomical heritage and to encourage nominations for World Heritage Sites relating to astronomy. I will review the main challenges and achievements so far, and suggest how the Astronomy and World Heritage Initiative is likely to develop in the future.Among the main milestones are the first two in a series of Thematic Studies (Ruggles and Cotte, 2010; 2015 in press), which help to establish broad principles for assessing the “value”, and ultimately the potential “outstanding universal value”, of different types of astronomical heritage, and the Portal to the Heritage of Astronomy, linked to the World Heritage Centre’s own website, which helps to raise awareness about important astronomical heritage sites and facilitates the comparative studies that form an essential part of any nomination dossier. Among the most challenging issues for the IAU has been how to recognise and protect the value of the dark night sky at places connected with astronomy—whether ancient sites, indigenous cultural landscapes, or modern observatories. A very significant development for the future is the IAU’s involvement in the “upstream process” whereby, along with UNESCO's advisory bodies, it can enter into discussion with, and give advice to, national authorities considering potential nominations.ReferencesRuggles, C. and Cotte, M., eds (2010) Heritage Sites of Astronomy and Archaeoastronomy: a Thematic Study. ICOMOS-IAU, Paris.

Supporting Greenhouse Gas Management Strategies with Observations and Analysis - Challenges and Opportunities

NASA Astrophysics Data System (ADS)

Butler, J. H.; Tarasova, O. A.

2014-12-01

Climate-change challenges facing society in the 21st century require an improved understanding of the global carbon-cycle and of the impacts and feedbacks of past, present, and future emissions of carbon-cycle gases. Global society faces a major challenge of reducing greenhouse gas emissions to virtually zero, most notably those of CO2, while at the same time facing variable and potentially overwhelming Earth System feedbacks. How it goes about this will depend upon the nature of impending international agreements, national laws, regional strategies, and social and economic forces. The challenge to those making observations to support, inform, or verify these reduction efforts, or to address potential Earth System feedbacks, lies in harmonizing a diverse array of observations and observing systems. Doing so is not trivial. Providing coherent, regional-scale information from these observations also requires improved modelling and ensemble reanalysis, but in the end such information must be relevant and reasonably certain. The challenge to us is to ensure a globally coherent observing and analysis system to supply the information that society will need to succeed. Policy-makers, scientists, government agencies, and businesses will need the best information available for decision-making and any observing and analysis system ultimately must be able to provide a coherent story over decades.

Accelerated measles control in the Western Pacific region.

PubMed

McFarland, Jeffrey W; Mansoor, Osman David; Yang, Baoping

2003-05-15

By the 1990s, an immunization program in the western Pacific had dramatically reduced measles morbidity and mortality. Building on the region's successful elimination of polio, several countries and areas achieved or are close to measles elimination, thus showing the potential for global eradication. The diverse challenges for measles control in different parts of the region have produced lessons that will help with future control, including the need for surveillance of sufficient standard to guide and monitor progress. A group of experts recognized both the potential and the challenges of the measles immunization program and proposed regional elimination as the appropriate disease control target for the region. No date was recommended for its achievement. If progress continues at the present rate, the western Pacific region should soon be able to set a target date for measles elimination.

Opportunities and Challenges in Realizing Universal Access to Obstetric Ultrasound in Sub-Saharan Africa

PubMed Central

Wanyonyi, Sikolia Z; Mariara, Charles Muriuki; Vinayak, Sudhir; Stones, William

2017-01-01

The potential benefits of obstetric ultrasound have yet to be fully realized in sub-Saharan Africa (SSA), despite the region bearing the greatest burden of poor perinatal outcomes. We reviewed the literature for challenges and opportunities of universal access to obstetric ultrasound and explored what is needed to make such access an integral component of maternity care in order to address the massive burden of perinatal morbidity and mortality in SSA. Original peer-reviewed literature was searched in various electronic databases using a ‘realist’ approach. While the available data were inconclusive, they identify many opportunities for potential future research on the subject within the region that can help build a strong case to justify the provision of universal access to ultrasound as an integral component of comprehensive antenatal care. PMID:28596999

eHealth recruitment challenges.

PubMed

Thompson, Debbe; Canada, Ashanti; Bhatt, Riddhi; Davis, Jennifer; Plesko, Lisa; Baranowski, Tom; Cullen, Karen; Zakeri, Issa

2006-11-01

Little is known about effective eHealth recruitment methods. This paper presents recruitment challenges associated with enrolling African-American girls aged 8-10 years in an eHealth obesity prevention program, their effect on the recruitment plan, and potential implications for eHealth research. Although the initial recruitment strategy was literature-informed, it failed to enroll the desired number of girls within a reasonable time period. Therefore, the recruitment strategy was reformulated to incorporate principles of social marketing and traditional marketing techniques. The resulting plan included both targeted, highly specific strategies (e.g., selected churches), and more broad-based approaches (e.g., media exposure, mass mailings, radio advertisements). The revised plan enabled recruitment goals to be attained. Media appeared to be particularly effective at reaching the intended audience. Future research should identify the most effective recruitment strategies for reaching potential eHealth audiences.

Carbon nanotube based transparent conductive films: progress, challenges, and perspectives

PubMed Central

Zhou, Ying; Azumi, Reiko

2016-01-01

Abstract Developments in the manufacturing technology of low-cost, high-quality carbon nanotubes (CNTs) are leading to increased industrial applications for this remarkable material. One of the most promising applications, CNT based transparent conductive films (TCFs), are an alternative technology in future electronics to replace traditional TCFs, which use indium tin oxide. Despite significant price competition among various TCFs, CNT-based TCFs have good potential for use in emerging flexible, stretchable and wearable optoelectronics. In this review, we summarize the recent progress in the fabrication, properties, stability and applications of CNT-based TCFs. The challenges of current CNT-based TCFs for industrial use, in comparison with other TCFs, are considered. We also discuss the potential of CNT-based TCFs, and give some possible strategies to reduce the production cost and improve their conductivity and transparency. PMID:27877899

Future Orientation in Times of Threat and Challenge: How Resilient Adolescents Construct Their Future

ERIC Educational Resources Information Center

Seginer, Rachel

2008-01-01

Drawing on the importance of future orientation for adolescent development this analysis presents a model describing how future orientation is affected by high challenge (or resilience) in the face of political violence. The analysis consists of three parts. The first two present future orientation conceptualization and the psychological processes…

A History of Neonatal Medicine—Past Accomplishments, Lessons Learned, and Future Challenges: Part II—The 1990s, the New Millennium, Future Challenges

PubMed Central

Lussky, Richard C.; Cifuentes, Raul F.; Siddappa, Ashajyothi M.

2005-01-01

This is the second of two articles reviewing the history of newborn medicine. This article will discuss recent accomplishments in the field of newborn medicine, current health outcome data, and future challenges facing the fields of neonatal and perinatal medicine. PMID:23118634

Multi-model and multi-scenario assessments of Asian water futures: The Water Futures and Solutions (WFaS) initiative

NASA Astrophysics Data System (ADS)

Satoh, Yusuke; Kahil, Taher; Byers, Edward; Burek, Peter; Fischer, Günther; Tramberend, Sylvia; Greve, Peter; Flörke, Martina; Eisner, Stephanie; Hanasaki, Naota; Magnuszewski, Piotr; Nava, Luzma Fabiola; Cosgrove, William; Langan, Simon; Wada, Yoshihide

2017-07-01

This paper presents one of the first quantitative scenario assessments for future water supply and demand in Asia to 2050. The assessment, developed by the Water Futures and Solutions (WFaS) initiative, uses the latest set of global climate change and socioeconomic scenarios and state-of-the-art global hydrological models. In Asia, water demand for irrigation, industry, and households is projected to increase substantially in the coming decades (30-40% by 2050 compared to 2010). These changes are expected to exacerbate water stress, especially in the current hotspots such as north India and Pakistan, and north China. By 2050, 20% of the land area in the Asia-Pacific region, with a population of 1.6-2 billion, is projected to experience severe water stress. We find that socioeconomic changes are the main drivers of worsening water scarcity in Asia, with climate change impacts further increasing the challenge into the 21st century. Moreover, a detailed basin-level analysis of the hydro-economic conditions of 40 Asian basins shows that although the coping capacity of all basins is expected to improve due to gross domestic product (GDP) growth, some basins continuously face severe water challenges. These basins will potentially be home to up to 1.6 billion people by mid-21st century.

The Importance of Studying Past Extreme Floods to Prepare for Uncertain Future Extremes

NASA Astrophysics Data System (ADS)

Burges, S. J.

2016-12-01

Hoyt and Langbein, 1955 in their book `Floods' wrote: " ..meteorologic and hydrologic conditions will combine to produce superfloods of unprecedented magnitude. We have every reason to believe that in most rivers past floods may not be an accurate measure of ultimate flood potentialities. It is this superflood with which we are always most concerned". I provide several examples to offer some historical perspective on assessing extreme floods. In one example, flooding in the Miami Valley, OH in 1913 claimed 350 lives. The engineering and socio-economic challenges facing the Morgan Engineering Co in how to mitigate against future flood damage and loss of life when limited information was available provide guidance about ways to face an uncertain hydroclimate future, particularly one of a changed climate. A second example forces us to examine mixed flood populations and illustrates the huge uncertainty in assigning flood magnitude and exceedance probability to extreme floods in such cases. There is large uncertainty in flood frequency estimates; knowledge of the total flood hydrograph, not the peak flood flow rate alone, is what is needed for hazard mitigation assessment or design. Some challenges in estimating the complete flood hydrograph in an uncertain future climate, including demands on hydrologic models and their inputs, are addressed.

Electrical Tomography for seismic hazard monitoring: state-of-the-art and future challenges.

NASA Astrophysics Data System (ADS)

Lapenna, Vincenzo; Piscitelli, Sabatino

2010-05-01

The Self-Potential (passive) and DC resistivity (active) methods have been considered for a long period as ancillary and/or secondary tools in geophysical exploration, simplified procedures for data processing and purely qualitative techniques for data inversion were the main drawbacks. Recently, innovative algorithms for tomographic data inversion, new models for describing the electrokinetic phenomena associated to the subsurface fluid migration and modern technologies for the field surveying have rapidly transformed these geoelectrical methods in powerful tools for geo-hazard monitoring. These technological and methodological improvements disclose the way for a wide spectra of interesting and challenging applications: mapping of the water content in landslide bodies; identification of fluid and gas emissions in volcanic areas; search of earthquake precursors. In this work we briefly resume the current start-of-the-art and analyse the new applications of the Electrical Tomography in the seismic hazard monitoring. An overview of the more interesting results obtained in different worldwide areas (i.e. Mediterranean Basin, California, Japan) is presented and discussed. To-date, combining novel techniques for data inversion and new strategies for the field data acquisition is possible to obtain high-resolution electrical images of complex geological structures. One of the key challenges for the near-future will be the integration of active (DC resistivity) and passive (Self-Potential) measurements for obtaining 2D, 3D and 4D electrical tomographies able to follow the spatial and temporal dynamics of electrical parameters (i.e. resistivity, self-potential). This approach could reduce the ambiguities related to the interpretation of anomalous SP signals in seismic active areas and their applicability for short-term earthquake prediction. The resistivity imaging can be applied for illuminating the fault geometry, while the SP imaging is the key instrument for capturing the fingerprints of the electrokinetic phenomena potentially generated in focal regions.

Veno-venous ECMO: a synopsis of nine key potential challenges, considerations, and controversies

PubMed Central

2014-01-01

Background Following the 2009 H1N1 Influenza pandemic, extracorporeal membrane oxygenation (ECMO) emerged as a viable alternative in selected, severe cases of ARDS. Acute Respiratory Distress Syndrome (ARDS) is a major public health problem. Average medical costs for ARDS survivors on an annual basis are multiple times those dedicated to a healthy individual. Advances in medical and ventilatory management of severe lung injury and ARDS have improved outcomes in some patients, but these advances fail to consistently “rescue” a significant proportion of those affected. Discussion Here we present a synopsis of the challenges, considerations, and potential controversies regarding veno-venous ECMO that will be of benefit to anesthesiologists, surgeons, and intensivists, especially those newly confronted with care of the ECMO patient. We outline a number of points related to ECMO, particularly regarding cannulation, pump/oxygenator design, anticoagulation, and intravascular fluid management of patients. We then address these challenges/considerations/controversies in the context of their potential future implications on clinical approaches to ECMO patients, focusing on the development and advancement of standardized ECMO clinical practices. Summary Since the 2009 H1N1 pandemic ECMO has gained a wider acceptance. There are challenges that still must be overcome. Further investigations of the benefits and effects of ECMO need to be undertaken in order to facilitate the implementation of this technology on a larger scale. PMID:25110462

Future potential for anti-infectives from bacteria - how to exploit biodiversity and genomic potential.

PubMed

Müller, Rolf; Wink, Joachim

2014-01-01

The early stages of antibiotic development include the identification of novel hit compounds. Since actinomycetes and myxobacteria are still the most important natural sources of active metabolites, we provide an overview on these producers and discuss three of the most promising approaches toward finding novel anti-infectives from microorganisms. These are defined as the use of biodiversity to find novel producers, the variation of culture conditions and induction of silent genes, and the exploitation of the genomic potential of producers via "genome mining". Challenges that exist beyond compound discovery are outlined in the last section. Copyright © 2013 Elsevier GmbH. All rights reserved.

Investing in Wisconsin's Future: A Proposal for a State Higher Education Nest Egg Program. WISCAPE Viewpoints

ERIC Educational Resources Information Center

Winters, Dennis

2010-01-01

Wisconsin will face serious challenges in the coming decades if it fails to increase the size and quality of the state workforce talent pool. One potential solution is a "Higher Ed Nest Egg Program", which would put $1,000 per student per year into an account with the sole purpose that the funds be used for postsecondary education in…

Mobile Social Networking Health (MSNet-Health): beyond the mHealth frontier.

PubMed

Househ, Mowafa

2012-01-01

The purpose of this conceptual paper is to introduce the concept of Mobile Social Networking Healthcare (MSNet-Health). The paper defines MSNet-Health and provides a working scenario of MSNet-Health. The paper suggests various potential domain area applications for MSNet-Health, such as diabetes, antenatal education, smoking cessation, weight loss, and arthritis. Challenges and future research areas are also discussed.

Challenges of Enterprise Wide AM for Air Force Sustainment

DTIC Science & Technology

2016-12-01

December 2016 Naguy is chief of the Air Force Life Cycle Management Center’s Product Support Engineering Division at Wright Patterson Air Force Base in...today and into the future. To truly capitalize on the full potential of AM, the Air Force Life Cycle Management Center (AFLCMC) in close collabora...approach for material standards and quality include un- derstanding powder characteristics, developing an enterprise material characterization

Building a collaborative network to understand regional forest dynamics and advance forestry initiatives in the Caribbean

Treesearch

Grizelle Gonzalez; Tamara Heartsill Scalley

2016-01-01

Herein we provide concluding remarks drawn from and inspired by the discussions of the 5 working groups of the 16th Caribbean Foresters Meeting (CFM) about the needs, challenges, and recommendations to advance forestry in the Caribbean region. We also list key considerations and potential future research directions as presented in the various manuscripts contained in...

Wildland fire management policy: Learning from the past and present and responding to future challenges

Treesearch

Tom Zimmerman

2009-01-01

Wildland fire is one of the most important vegetation- shaping factors that land managers deal with. It is our highest risk, most complex, and potentially highest consequence program. Wildland fire management policy is the most important element in defining the direction, scope, and focus of the program. What is policy? If we look it up in Merriam-Webster's...

Research Suggestions in the Design of a Global Graduate Business Program Delivered by Online Learning

ERIC Educational Resources Information Center

Puderbaugh, Amy

2015-01-01

The purpose of this paper was to examine the unique areas of concern when establishing an eLearning program in the field of global business. A survey of eLearning and a global management subject matter appears. This paper identifies potential challenges in program design and raises practical concerns for future research. [For the full proceedings,…

Climate change in the age of humans

Treesearch

J. Curt Stager

2014-01-01

The Anthropocene epoch presents a mix of old and new challenges for the world’s forests. Climatic instability has typified most of the Cenozoic Era but today’s situation is unique due to the presence of billions of humans on the planet. The potential rate and magnitude of future warming driven by continued fossil fuel combustion could be unprecedented during the last...

A Millennial Challenge: Extremism in Uncertain Times

PubMed Central

Fiske, Susan T.

2014-01-01

This comment highlights the relevance and importance of the uncertainty-extremism topic, both scientifically and societally, identifies common themes, locates this work in a wider scientific and social context, describes what we now know and what we still do not, acknowledges some limitations, foreshadowing future directions, and discusses some potential policy relevance. Common themes emerge around the importance of social justice as sound anti-extremism policy. PMID:24511155

Young People's Health as a Challenge for Physical Education in Schools in the Twenty-First Century: The Case of Flanders (Belgium)

ERIC Educational Resources Information Center

Seghers, Jan; de Martelaer, Kristine; Cardon, Greet

2009-01-01

Background: A lack of physical activity (PA) and the occurrence of overweight and obesity among school-aged youth have become a major societal problem. Arising from the general concern about the future generations' health, schools have been found to be potentially important settings to promote positive health behaviour, since all pupils can be…

Miconia biocontrol: Where are we going and when will we get there?

Treesearch

M.T. Johnson

2010-01-01

We have made much progress in evaluating potential agents for biocontrol of miconia, and several appear likely to be suitable for future introduction to Hawaiÿi. Unfortunately, none of them is an obvious silver bullet. We face the challenge of prioritizing the existing candidates and inventing the combination of agents that will achieve our goals. Now is an opportune...

Remote-sensing based approach to forecast habitat quality under climate change scenarios.

PubMed

Requena-Mullor, Juan M; López, Enrique; Castro, Antonio J; Alcaraz-Segura, Domingo; Castro, Hermelindo; Reyes, Andrés; Cabello, Javier

2017-01-01

As climate change is expected to have a significant impact on species distributions, there is an urgent challenge to provide reliable information to guide conservation biodiversity policies. In addressing this challenge, we propose a remote sensing-based approach to forecast the future habitat quality for European badger, a species not abundant and at risk of local extinction in the arid environments of southeastern Spain, by incorporating environmental variables related with the ecosystem functioning and correlated with climate and land use. Using ensemble prediction methods, we designed global spatial distribution models for the distribution range of badger using presence-only data and climate variables. Then, we constructed regional models for an arid region in the southeast Spain using EVI (Enhanced Vegetation Index) derived variables and weighting the pseudo-absences with the global model projections applied to this region. Finally, we forecast the badger potential spatial distribution in the time period 2071-2099 based on IPCC scenarios incorporating the uncertainty derived from the predicted values of EVI-derived variables. By including remotely sensed descriptors of the temporal dynamics and spatial patterns of ecosystem functioning into spatial distribution models, results suggest that future forecast is less favorable for European badgers than not including them. In addition, change in spatial pattern of habitat suitability may become higher than when forecasts are based just on climate variables. Since the validity of future forecast only based on climate variables is currently questioned, conservation policies supported by such information could have a biased vision and overestimate or underestimate the potential changes in species distribution derived from climate change. The incorporation of ecosystem functional attributes derived from remote sensing in the modeling of future forecast may contribute to the improvement of the detection of ecological responses under climate change scenarios.

Remote-sensing based approach to forecast habitat quality under climate change scenarios

PubMed Central

Requena-Mullor, Juan M.; López, Enrique; Castro, Antonio J.; Alcaraz-Segura, Domingo; Castro, Hermelindo; Reyes, Andrés; Cabello, Javier

2017-01-01

As climate change is expected to have a significant impact on species distributions, there is an urgent challenge to provide reliable information to guide conservation biodiversity policies. In addressing this challenge, we propose a remote sensing-based approach to forecast the future habitat quality for European badger, a species not abundant and at risk of local extinction in the arid environments of southeastern Spain, by incorporating environmental variables related with the ecosystem functioning and correlated with climate and land use. Using ensemble prediction methods, we designed global spatial distribution models for the distribution range of badger using presence-only data and climate variables. Then, we constructed regional models for an arid region in the southeast Spain using EVI (Enhanced Vegetation Index) derived variables and weighting the pseudo-absences with the global model projections applied to this region. Finally, we forecast the badger potential spatial distribution in the time period 2071–2099 based on IPCC scenarios incorporating the uncertainty derived from the predicted values of EVI-derived variables. By including remotely sensed descriptors of the temporal dynamics and spatial patterns of ecosystem functioning into spatial distribution models, results suggest that future forecast is less favorable for European badgers than not including them. In addition, change in spatial pattern of habitat suitability may become higher than when forecasts are based just on climate variables. Since the validity of future forecast only based on climate variables is currently questioned, conservation policies supported by such information could have a biased vision and overestimate or underestimate the potential changes in species distribution derived from climate change. The incorporation of ecosystem functional attributes derived from remote sensing in the modeling of future forecast may contribute to the improvement of the detection of ecological responses under climate change scenarios. PMID:28257501

Review of Potential Characterization Techniques in Approaching Energy and Sustainability

DOE PAGES

LePoire, David

2014-03-20

Societal prosperity is linked to sustainable energy and a healthy environment. But, tough global challenges include increased demand for fossil fuels, while approaching peak oil production and uncertainty in the environmental impacts of energy generation. Recently, energy use was identified as a major component of economic productivity, along with capital and labor. Furthermore, other environmental resources and impacts may be nearing environmental thresholds as indicated by nine planetary environmental boundaries, many of which are linked to energy production and use. Foresight techniques could be applied to guide future actions which include emphasis on (1) energy efficiency to bridge the transitionmore » to a renewable energy economy, (2) continued research, development, and assessment of new technologies, (3) improved understanding of environment impacts including natural capital use and degradation, (4) exploration of GDP alternative measures that include both economic production and environmental impacts, and (5) international cooperation and awareness of longer-term opportunities and their associated potential scenarios. Examples from the U.S. and the international community illustrate challenges and potential.« less

Dogs in the Workplace: A Review of the Benefits and Potential Challenges.

PubMed

Foreman, Anne M; Glenn, Margaret K; Meade, B Jean; Wirth, Oliver

2017-05-08

Pet dogs, therapy dogs, and service dogs can be seen in workplaces with increasing frequency. Although dogs may provide many benefits to employees and employers, their presence may introduce additional hazards and concerns to the work environment. Therefore, decisions to accept dogs in the workplace may include many considerations including the health, safety, and well-being of employees, legal and cultural sensitivities, and animal welfare. The present paper serves to introduce the issue of dogs in the workplace and outline the potential benefits and challenges to their presence. The legal accommodations afforded to certain types of dogs in workplace settings are discussed, and the research findings pertaining to the potential benefits of dogs on human health and well-being are summarized. The paper concludes with considerations for human resource management personnel in the areas of diversity, employee relations, ethics and corporate responsibility, organizational and employee development, safety and security, and legal considerations, as well as suggested topics for future research.

Schistosomiasis Elimination Strategies and Potential Role of a Vaccine in Achieving Global Health Goals

PubMed Central

Mo, Annie X.; Agosti, Jan M.; Walson, Judd L.; Hall, B. Fenton; Gordon, Lance

2014-01-01

In March 2013, the National Institute of Allergy and Infectious Diseases and the Bill and Melinda Gates Foundation co-sponsored a meeting entitled “Schistosomiasis Elimination Strategy and Potential Role of a Vaccine in Achieving Global Health Goals” to discuss the potential role of schistosomiasis vaccines and other tools in the context of schistosomiasis control and elimination strategies. It was concluded that although schistosomiasis elimination in some focal areas may be achievable through current mass drug administration programs, global control and elimination will face several significant scientific and operational challenges, and will require an integrated approach with other, additional interventions. These challenges include vector (snail) control; environmental modification; water, sanitation, and hygiene; and other future innovative tools such as vaccines. Defining a clear product development plan that reflects a vaccine strategy as complementary to the existing control programs to combat different forms of schistosomiasis will be important to develop a vaccine effectively. PMID:24402703

Dogs in the Workplace: A Review of the Benefits and Potential Challenges

PubMed Central

Foreman, Anne M.; Glenn, Margaret K.; Meade, B. Jean; Wirth, Oliver

2017-01-01

Pet dogs, therapy dogs, and service dogs can be seen in workplaces with increasing frequency. Although dogs may provide many benefits to employees and employers, their presence may introduce additional hazards and concerns to the work environment. Therefore, decisions to accept dogs in the workplace may include many considerations including the health, safety, and well-being of employees, legal and cultural sensitivities, and animal welfare. The present paper serves to introduce the issue of dogs in the workplace and outline the potential benefits and challenges to their presence. The legal accommodations afforded to certain types of dogs in workplace settings are discussed, and the research findings pertaining to the potential benefits of dogs on human health and well-being are summarized. The paper concludes with considerations for human resource management personnel in the areas of diversity, employee relations, ethics and corporate responsibility, organizational and employee development, safety and security, and legal considerations, as well as suggested topics for future research. PMID:28481317

Lignin conversion: Opportunities and challenges for the integrated biorefinery

DOE PAGES

Xie, Shangxian; Ragauskas, Arthur J.; Yuan, Joshua S.

2016-06-21

The utilization of lignin for fungible fuels and products represents one of the most imminent challenges in the modern biorefinery because most of the bioprocesses for lignocellulosic biofuels results in a lignin-containing waste stream. Considering lignin's abundance and relatively high energy content, this waste stream can be used as a feedstock for value-added products to improve the sustainability and economic feasibility of the biorefinery. Bioconversion of lignin with microbes recently emerged as an alternative lignin-valorization approach with significant potential. Typically, the microbial bioconversion of lignin requires three major steps: lignin depolymerization, aromatic compounds catabolism, and target product biosynthesis. In thismore » review, we summarize the most recent advances in lignin bioconversion to address the challenges in each of the three steps. In conclusion, we further discuss strategies and perspectives for future research to address the challenges in bioconversion of lignin.« less

Lignin conversion: Opportunities and challenges for the integrated biorefinery

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xie, Shangxian; Ragauskas, Arthur J.; Yuan, Joshua S.

The utilization of lignin for fungible fuels and products represents one of the most imminent challenges in the modern biorefinery because most of the bioprocesses for lignocellulosic biofuels results in a lignin-containing waste stream. Considering lignin's abundance and relatively high energy content, this waste stream can be used as a feedstock for value-added products to improve the sustainability and economic feasibility of the biorefinery. Bioconversion of lignin with microbes recently emerged as an alternative lignin-valorization approach with significant potential. Typically, the microbial bioconversion of lignin requires three major steps: lignin depolymerization, aromatic compounds catabolism, and target product biosynthesis. In thismore » review, we summarize the most recent advances in lignin bioconversion to address the challenges in each of the three steps. In conclusion, we further discuss strategies and perspectives for future research to address the challenges in bioconversion of lignin.« less

Advanced protein formulations

PubMed Central

Wang, Wei

2015-01-01

It is well recognized that protein product development is far more challenging than that for small-molecule drugs. The major challenges include inherent sensitivity to different types of stresses during the drug product manufacturing process, high rate of physical and chemical degradation during long-term storage, and enhanced aggregation and/or viscosity at high protein concentrations. In the past decade, many novel formulation concepts and technologies have been or are being developed to address these product development challenges for proteins. These concepts and technologies include use of uncommon/combination of formulation stabilizers, conjugation or fusion with potential stabilizers, site-specific mutagenesis, and preparation of nontraditional types of dosage forms—semiaqueous solutions, nonfreeze-dried solid formulations, suspensions, and other emerging concepts. No one technology appears to be mature, ideal, and/or adequate to address all the challenges. These gaps will likely remain in the foreseeable future and need significant efforts for ultimate resolution. PMID:25858529

Grand Challenges of Advanced Computing for Energy Innovation Report from the Workshop Held July 31-August 2, 2012

DOE Office of Scientific and Technical Information (OSTI.GOV)

Larzelere, Alex R.; Ashby, Steven F.; Christensen, Dana C.

2013-03-06

On July 31-August 2 of 2012, the U.S. Department of Energy (DOE) held a workshop entitled Grand Challenges of Advanced Computing for Energy Innovation. This workshop built on three earlier workshops that clearly identified the potential for the Department and its national laboratories to enable energy innovation. The specific goal of the workshop was to identify the key challenges that the nation must overcome to apply the full benefit of taxpayer-funded advanced computing technologies to U.S. energy innovation in the ways that the country produces, moves, stores, and uses energy. Perhaps more importantly, the workshop also developed a set ofmore » recommendations to help the Department overcome those challenges. These recommendations provide an action plan for what the Department can do in the coming years to improve the nation’s energy future.« less

Digital media in the home: technical and research challenges

NASA Astrophysics Data System (ADS)

Ribas-Corbera, Jordi

2005-03-01

This article attempts to identify some of the technology and research challenges facing the digital media industry in the future. We first discuss several trends in the industry, such as the rapid growth of broadband Internet networks and the emergence of networking and media-capable devices in the home. Next, we present technical challenges that result from these trends, such as effective media interoperability in devices, and provide a brief overview of Windows Media, which is one of the technologies in the market attempting to address these challenges. Finally, given these trends and the state of the art, we argue that further research on data compression, encoder optimization, and multi-format transcoding can potentially make a significant technical and business impact in digital media. We also explore the reasons that research on related techniques such as wavelets or scalable video coding is having a relatively minor impact in today"s practical digital media systems.

A Brief Review of the Need for Robust Smart Wireless Sensor Systems for Future Propulsion Systems, Distributed Engine Controls, and Propulsion Health Management

NASA Technical Reports Server (NTRS)

Hunter, Gary W.; Behbahani, Alireza

2012-01-01

Smart Sensor Systems with wireless capability operational in high temperature, harsh environments are a significant component in enabling future propulsion systems to meet a range of increasingly demanding requirements. These propulsion systems must incorporate technology that will monitor engine component conditions, analyze the incoming data, and modify operating parameters to optimize propulsion system operations. This paper discusses the motivation towards the development of high temperature, smart wireless sensor systems that include sensors, electronics, wireless communication, and power. The challenges associated with the use of traditional wired sensor systems will be reviewed and potential advantages of Smart Sensor Systems will be discussed. A brief review of potential applications for wireless smart sensor networks and their potential impact on propulsion system operation, with emphasis on Distributed Engine Control and Propulsion Health Management, will be given. A specific example related to the development of high temperature Smart Sensor Systems based on silicon carbide electronics will be discussed. It is concluded that the development of a range of robust smart wireless sensor systems are a foundation for future development of intelligent propulsion systems with enhanced capabilities.

How to deal with climate change uncertainty in the planning of engineering systems

NASA Astrophysics Data System (ADS)

Spackova, Olga; Dittes, Beatrice; Straub, Daniel

2016-04-01

The effect of extreme events such as floods on the infrastructure and built environment is associated with significant uncertainties: These include the uncertain effect of climate change, uncertainty on extreme event frequency estimation due to limited historic data and imperfect models, and, not least, uncertainty on future socio-economic developments, which determine the damage potential. One option for dealing with these uncertainties is the use of adaptable (flexible) infrastructure that can easily be adjusted in the future without excessive costs. The challenge is in quantifying the value of adaptability and in finding the optimal sequence of decision. Is it worth to build a (potentially more expensive) adaptable system that can be adjusted in the future depending on the future conditions? Or is it more cost-effective to make a conservative design without counting with the possible future changes to the system? What is the optimal timing of the decision to build/adjust the system? We develop a quantitative decision-support framework for evaluation of alternative infrastructure designs under uncertainties, which: • probabilistically models the uncertain future (trough a Bayesian approach) • includes the adaptability of the systems (the costs of future changes) • takes into account the fact that future decisions will be made under uncertainty as well (using pre-posterior decision analysis) • allows to identify the optimal capacity and optimal timing to build/adjust the infrastructure. Application of the decision framework will be demonstrated on an example of flood mitigation planning in Bavaria.

Passive Thermal Control Challenges for Future Exploration Missions

NASA Technical Reports Server (NTRS)

Rickman, Steven L.

2004-01-01

This slide presentation reviews the importance of developing passive thermal control for the future exploration missions envisioned in President Bush's call for human exploration of the Moon and Mars. Included in the presentation is a review of the conditions that make the thermal control very challenging on the Moon and Mars. With the future miniaturization of electronics components, power density and the associated challenges of electronics heat dissipation will provide new challenges. There is a challenge for improvement in modeling and analysis of thermal control systems, and for improved facilities to support testing of thermal-vacuum systems.

Projected changes in daily fire spread across Canada over the next century

NASA Astrophysics Data System (ADS)

Wang, Xianli; Parisien, Marc-André; Taylor, Steve W.; Candau, Jean-Noël; Stralberg, Diana; Marshall, Ginny A.; Little, John M.; Flannigan, Mike D.

2017-02-01

In the face of climate change, predicting and understanding future fire regimes across Canada is a high priority for wildland fire research and management. Due in large part to the difficulties in obtaining future daily fire weather projections, one of the major challenges in predicting future fire activity is to estimate how much of the change in weather potential could translate into on-the-ground fire spread. As a result, past studies have used monthly, annual, or multi-decadal weather projections to predict future fires, thereby sacrificing information relevant to day-to-day fire spread. Using climate projections from the fifth phase of the Coupled Model Intercomparison Project (CMIP5), historical weather observations, MODIS fire detection data, and the national fire database of Canada, this study investigated potential changes in the number of active burning days of wildfires by relating ‘spread days’ to patterns of daily fire-conducive weather. Results suggest that climate change over the next century may have significant impacts on fire spread days in almost all parts of Canada’s forested landmass; the number of fire spread days could experience a 2-to-3-fold increase under a high CO2 forcing scenario in eastern Canada, and a greater than 50% increase in western Canada, where the fire potential is already high. The change in future fire spread is critical in understanding fire regime changes, but is also imminently relevant to fire management operations and in fire risk mitigation.

The changing face of nanomaterials: Risk assessment challenges along the value chain.

PubMed

Mattsson, Mats-Olof; Simkó, Myrtill

2017-03-01

Risk assessment (RA) of manufactured nanomaterials (MNM) is essential for regulatory purposes and risk management activities. Similar to RA of "classical" chemicals, MNM RA requires knowledge about exposure as well as of hazard potential and dose response relationships. What makes MNM RA especially challenging is the multitude of materials (which is expected to increase substantially in the future), the complexity of MNM value chains and life cycles, the accompanying possible changes in material properties over time and in contact with various environmental and organismal milieus, and the difficulties to obtain proper exposure data and to consider the proper dose metric. This article discusses these challenges and also critically overviews the current state of the art regarding MNM RA approaches. Copyright © 2016 Elsevier Inc. All rights reserved.

Therapeutic Genome Editing: Prospects and Challenges

PubMed Central

Cox, David Benjamin Turitz; Platt, Randall Jeffrey; Zhang, Feng

2015-01-01

Recent advances in the development of genome editing technologies based on programmable nucleases have significantly improved our ability to make precise changes in the genomes of eukaryotic cells. Genome editing is already broadening our ability to elucidate the contribution of genetics to disease by facilitating the creation of more accurate cellular and animal models of pathological processes. A particularly tantalizing application of programmable nucleases is the potential to directly correct genetic mutations in affected tissues and cells to treat diseases that are refractory to traditional therapies. Here we discuss current progress towards developing programmable nuclease-based therapies as well as future prospects and challenges. PMID:25654603

Alkali Metal Rankine Cycle Boiler Technology Challenges and Some Potential Solutions for Space Nuclear Power and Propulsion Applications

NASA Technical Reports Server (NTRS)

Stone, James R.

1994-01-01

Alkali metal boilers are of interest for application to future space Rankine cycle power conversion systems. Significant progress on such boilers was accomplished in the 1960's and early 1970's, but development was not continued to operational systems since NASA's plans for future space missions were drastically curtailed in the early 1970's. In particular, piloted Mars missions were indefinitely deferred. With the announcement of the Space Exploration Initiative (SEI) in July 1989 by President Bush, interest was rekindled in challenging space missions and, consequently in space nuclear power and propulsion. Nuclear electric propulsion (NEP) and nuclear thermal propulsion (NTP) were proposed for interplanetary space vehicles, particularly for Mars missions. The potassium Rankine power conversion cycle became of interest to provide electric power for NEP vehicles and for 'dual-mode' NTP vehicles, where the same reactor could be used directly for propulsion and (with an additional coolant loop) for power. Although the boiler is not a major contributor to system mass, it is of critical importance because of its interaction with the rest of the power conversion system; it can cause problems for other components such as excess liquid droplets entering the turbine, thereby reducing its life, or more critically, it can drive instabilities-some severe enough to cause system failure. Funding for the SEI and its associated technology program from 1990 to 1993 was not sufficient to support significant new work on Rankine cycle boilers for space applications. In Fiscal Year 1994, funding for these challenging missions and technologies has again been curtailed, and planning for the future is very uncertain. The purpose of this paper is to review the technologies developed in the 1960's and 1970's in the light of the recent SEI applications. In this way, future Rankine cycle boiler programs may be conducted most efficiently. This report is aimed at evaluating alkali metal boiler technology for space Rankine cycle systems. Research is summarized on the problems of flow stability, liquid carryover, pressure drop and heat transfer, and on potential solutions developed, primarily those developed by the NASA Lewis Research Center in the 1960's and early 1970's.

Personalizing health care: feasibility and future implications.

PubMed

Godman, Brian; Finlayson, Alexander E; Cheema, Parneet K; Zebedin-Brandl, Eva; Gutiérrez-Ibarluzea, Inaki; Jones, Jan; Malmström, Rickard E; Asola, Elina; Baumgärtel, Christoph; Bennie, Marion; Bishop, Iain; Bucsics, Anna; Campbell, Stephen; Diogene, Eduardo; Ferrario, Alessandra; Fürst, Jurij; Garuoliene, Kristina; Gomes, Miguel; Harris, Katharine; Haycox, Alan; Herholz, Harald; Hviding, Krystyna; Jan, Saira; Kalaba, Marija; Kvalheim, Christina; Laius, Ott; Lööv, Sven-Ake; Malinowska, Kamila; Martin, Andrew; McCullagh, Laura; Nilsson, Fredrik; Paterson, Ken; Schwabe, Ulrich; Selke, Gisbert; Sermet, Catherine; Simoens, Steven; Tomek, Dominik; Vlahovic-Palcevski, Vera; Voncina, Luka; Wladysiuk, Magdalena; van Woerkom, Menno; Wong-Rieger, Durhane; Zara, Corrine; Ali, Raghib; Gustafsson, Lars L

2013-08-13

Considerable variety in how patients respond to treatments, driven by differences in their geno- and/ or phenotypes, calls for a more tailored approach. This is already happening, and will accelerate with developments in personalized medicine. However, its promise has not always translated into improvements in patient care due to the complexities involved. There are also concerns that advice for tests has been reversed, current tests can be costly, there is fragmentation of funding of care, and companies may seek high prices for new targeted drugs. There is a need to integrate current knowledge from a payer's perspective to provide future guidance. Multiple findings including general considerations; influence of pharmacogenomics on response and toxicity of drug therapies; value of biomarker tests; limitations and costs of tests; and potentially high acquisition costs of new targeted therapies help to give guidance on potential ways forward for all stakeholder groups. Overall, personalized medicine has the potential to revolutionize care. However, current challenges and concerns need to be addressed to enhance its uptake and funding to benefit patients.

Personalizing health care: feasibility and future implications

PubMed Central

2013-01-01

Considerable variety in how patients respond to treatments, driven by differences in their geno- and/ or phenotypes, calls for a more tailored approach. This is already happening, and will accelerate with developments in personalized medicine. However, its promise has not always translated into improvements in patient care due to the complexities involved. There are also concerns that advice for tests has been reversed, current tests can be costly, there is fragmentation of funding of care, and companies may seek high prices for new targeted drugs. There is a need to integrate current knowledge from a payer’s perspective to provide future guidance. Multiple findings including general considerations; influence of pharmacogenomics on response and toxicity of drug therapies; value of biomarker tests; limitations and costs of tests; and potentially high acquisition costs of new targeted therapies help to give guidance on potential ways forward for all stakeholder groups. Overall, personalized medicine has the potential to revolutionize care. However, current challenges and concerns need to be addressed to enhance its uptake and funding to benefit patients. PMID:23941275

The challenge of monitoring the cryosphere in alpine environments: Prepare the present for the future

NASA Astrophysics Data System (ADS)

Fischer, Andrea; Helfricht, Kay; Seiser, Bernd; Stocker-Waldhuber, Martin; Hartl, Lea; Wiesenegger, Hans

2017-04-01

Understanding the interaction of mountain glaciers and permafrost with weather and climate is essential for the interpretation of past states of the cryosphere in terms of climate change. Most of the glaciers and rock glaciers in Eastern Alpine terrain are subject to strong gradients in climatic forcing, and the persistence of these gradients under past climatic conditions is, more or less, unknown. Thus a key challenge of monitoring the cryosphere is to define the demands on a monitoring strategy for capturing essential processes and their potential changes. For example, the effects of orographic precipitation and local shading vary with general circulation patterns and the amount of solar radiation during the melt(ing) season. Recent investigations based on the Austrian glacier inventories have shown that glacier distribution is closely linked to topography and climatic situation, and that these two parameters imply also different sensitivities of the specific glaciers to progressing climate change. This leads to the need to develop a monitoring system capturing past, but also fairly unknown future ensembles of climatic state and sensitivities. As a first step, the Austrian glacier monitoring network has been analyzed from the beginning of the records onwards. Today's monitoring network bears the imprints of past research interests, but also past funding policies and personal/institutional engagements. As a limitation for long term monitoring in general, today's monitoring strategies have to cope with being restricted to these historical commitments to preserve the length of the time series, but at the same time expanding the measurements to fulfil present and future scientific and societal demands. The decision on cryospheric benchmark sites has an additional uncertainty: the ongoing disintegration of glaciers, their increasing debris cover as well as the potential low ice content and relatively unknown reaction of rock glaciers in the course of climate change, limits the number of potential candidates for future monitoring drastically. In the light of these developments, sample sizes are a critical question for reliable monitoring, together with strategies for coping with changing monitoring sites and composition of time series. As a first step, the Austrian monitoring network has been analyzed from 1891 onwards. Past changes evident from the glacier inventories capturing all glaciers have been compared to the subsamples of glaciers monitored for length change, mass balance and ice flow velocities. The results show that for capturing the full bandwidth of regional changes, glacier inventories are necessary. Without the analysis of larger scale changes, the interpretation of records with very low sample sizes, such as mass balance or length change, has a high uncertainty level. For specific research or monitoring purposes, for example, the development of runoff master sites with all types of monitoring techniques improve the certainty of the spatial extrapolations of local records or the interpretation of volume changes. The challenge of preparing the present network for the future requires a thorough analysis of potential future developments to be able to switch sites with a common observation period necessary to investigate the different sensitivities.

Diagnosis of Ebola Virus Disease: Past, Present, and Future

PubMed Central

Brooks, Tim J. G.

2016-01-01

SUMMARY Laboratory diagnosis of Ebola virus disease plays a critical role in outbreak response efforts; however, establishing safe and expeditious testing strategies for this high-biosafety-level pathogen in resource-poor environments remains extremely challenging. Since the discovery of Ebola virus in 1976 via traditional viral culture techniques and electron microscopy, diagnostic methodologies have trended toward faster, more accurate molecular assays. Importantly, technological advances have been paired with increasing efforts to support decentralized diagnostic testing capacity that can be deployed at or near the point of patient care. The unprecedented scope of the 2014-2015 West Africa Ebola epidemic spurred tremendous innovation in this arena, and a variety of new diagnostic platforms that have the potential both to immediately improve ongoing surveillance efforts in West Africa and to transform future outbreak responses have reached the field. In this review, we describe the evolution of Ebola virus disease diagnostic testing and efforts to deploy field diagnostic laboratories in prior outbreaks. We then explore the diagnostic challenges pervading the 2014-2015 epidemic and provide a comprehensive examination of novel diagnostic tests that are likely to address some of these challenges moving forward. PMID:27413095

Personalized Medicine and Genomics: Challenges and Opportunities in Assessing Effectiveness, Cost-Effectiveness, and Future Research Priorities

PubMed Central

Conti, Rena; Veenstra, David L.; Armstrong, Katrina; Lesko, Lawrence J.; Grosse, Scott D.

2015-01-01

Personalized medicine is health care that tailors interventions to individual variation in risk and treatment response. Although medicine has long strived to achieve this goal, advances in genomics promise to facilitate this process. Relevant to present-day practice is the use of genomic information to classify individuals according to disease susceptibility or expected responsiveness to a pharmacologic treatment and to provide targeted interventions. A symposium at the annual meeting of the Society for Medical Decision Making on 23 October 2007 highlighted the challenges and opportunities posed in translating advances in molecular medicine into clinical practice. A panel of US experts in medical practice, regulatory policy, technology assessment, and the financing and organization of medical innovation was asked to discuss the current state of practice and research on personalized medicine as it relates to their own field. This article reports on the issues raised, discusses potential approaches to meet these challenges, and proposes directions for future work. The case of genetic testing to inform dosing with warfarin, an anticoagulant, is used to illustrate differing perspectives on evidence and decision making for personalized medicine. PMID:20086232

Applied aerodynamics: Challenges and expectations

NASA Technical Reports Server (NTRS)

Peterson, Victor L.; Smith, Charles A.

1993-01-01

Aerospace is the leading positive contributor to this country's balance of trade, derived largely from the sale of U.S. commercial aircraft around the world. This powerfully favorable economic situation is being threatened in two ways: (1) the U.S. portion of the commercial transport market is decreasing, even though the worldwide market is projected to increase substantially; and (2) expenditures are decreasing for military aircraft, which often serve as proving grounds for advanced aircraft technology. To retain a major share of the world market for commercial aircraft and continue to provide military aircraft with unsurpassed performance, the U.S. aerospace industry faces many technological challenges. The field of applied aerodynamics is necessarily a major contributor to efforts aimed at meeting these technological challenges. A number of emerging research results that will provide new opportunities for applied aerodynamicists are discussed. Some of these have great potential for maintaining the high value of contributions from applied aerodynamics in the relatively near future. Over time, however, the value of these contributions will diminish greatly unless substantial investments continue to be made in basic and applied research efforts. The focus: to increase understanding of fluid dynamic phenomena, identify new aerodynamic concepts, and provide validated advanced technology for future aircraft.

Earth BioGenome Project: Sequencing life for the future of life.

PubMed

Lewin, Harris A; Robinson, Gene E; Kress, W John; Baker, William J; Coddington, Jonathan; Crandall, Keith A; Durbin, Richard; Edwards, Scott V; Forest, Félix; Gilbert, M Thomas P; Goldstein, Melissa M; Grigoriev, Igor V; Hackett, Kevin J; Haussler, David; Jarvis, Erich D; Johnson, Warren E; Patrinos, Aristides; Richards, Stephen; Castilla-Rubio, Juan Carlos; van Sluys, Marie-Anne; Soltis, Pamela S; Xu, Xun; Yang, Huanming; Zhang, Guojie

2018-04-24

Increasing our understanding of Earth's biodiversity and responsibly stewarding its resources are among the most crucial scientific and social challenges of the new millennium. These challenges require fundamental new knowledge of the organization, evolution, functions, and interactions among millions of the planet's organisms. Herein, we present a perspective on the Earth BioGenome Project (EBP), a moonshot for biology that aims to sequence, catalog, and characterize the genomes of all of Earth's eukaryotic biodiversity over a period of 10 years. The outcomes of the EBP will inform a broad range of major issues facing humanity, such as the impact of climate change on biodiversity, the conservation of endangered species and ecosystems, and the preservation and enhancement of ecosystem services. We describe hurdles that the project faces, including data-sharing policies that ensure a permanent, freely available resource for future scientific discovery while respecting access and benefit sharing guidelines of the Nagoya Protocol. We also describe scientific and organizational challenges in executing such an ambitious project, and the structure proposed to achieve the project's goals. The far-reaching potential benefits of creating an open digital repository of genomic information for life on Earth can be realized only by a coordinated international effort.

Challenges and future direction of molecular research in air pollution-related lung cancers.

PubMed

Shahadin, Maizatul Syafinaz; Ab Mutalib, Nurul Syakima; Latif, Mohd Talib; Greene, Catherine M; Hassan, Tidi

2018-04-01

Hazardous air pollutants or chemical release into the environment by a variety of natural and/or anthropogenic activities may give adverse effects to human health. Air pollutants such as sulphur dioxide (SO2), nitrogen oxides (NOx), carbon monoxide (CO), heavy metals and particulate matter (PM) affect number of different human organs, especially the respiratory system. The International Agency for Research on Cancer (IARC) reported that ambient air pollution is a cause of lung cancer. Recently, the agency has classified outdoor air pollution as well as PM air pollution as Group 1 carcinogens. In addition, several epidemiological studies have shown a positive association between air pollutants to lung cancer risks and mortality. However, there are only a few studies examining the molecular effects of air pollution exposure specifically in lung cancer due to multiple challenges to mimic air pollution exposure in basic experimentation. Another major issue is the lack of adequate adjustments for exposure misclassification as air pollution may differ temporo-spatially and socioeconomically. Thus, the purpose of this paper is to review the current molecular understanding of air pollution-related lung cancer and potential future direction in this challenging yet important research field. Copyright © 2018 Elsevier B.V. All rights reserved.

The Challenging Experience Questionnaire: Characterization of challenging experiences with psilocybin mushrooms.

PubMed

Barrett, Frederick S; Bradstreet, Matthew P; Leoutsakos, Jeannie-Marie S; Johnson, Matthew W; Griffiths, Roland R

2016-12-01

Acute adverse psychological reactions to classic hallucinogens ("bad trips" or "challenging experiences"), while usually benign with proper screening, preparation, and support in controlled settings, remain a safety concern in uncontrolled settings (such as illicit use contexts). Anecdotal and case reports suggest potential adverse acute symptoms including affective (panic, depressed mood), cognitive (confusion, feelings of losing sanity), and somatic (nausea, heart palpitation) symptoms. Responses to items from several hallucinogen-sensitive questionnaires (Hallucinogen Rating Scale, the States of Consciousness Questionnaire, and the Five-Dimensional Altered States of Consciousness questionnaire) in an Internet survey of challenging experiences with the classic hallucinogen psilocybin were used to construct and validate a Challenging Experience Questionnaire. The stand-alone Challenging Experience Questionnaire was then validated in a separate sample. Seven Challenging Experience Questionnaire factors (grief, fear, death, insanity, isolation, physical distress, and paranoia) provide a phenomenological profile of challenging aspects of experiences with psilocybin. Factor scores were associated with difficulty, meaningfulness, spiritual significance, and change in well-being attributed to the challenging experiences. The factor structure did not differ based on gender or prior struggle with anxiety or depression. The Challenging Experience Questionnaire provides a basis for future investigation of predictors and outcomes of challenging experiences with classic hallucinogens. © The Author(s) 2016.

Exoskeleton robots for upper-limb rehabilitation: state of the art and future prospects.

PubMed

Lo, Ho Shing; Xie, Sheng Quan

2012-04-01

Current health services are struggling to provide optimal rehabilitation therapy to victims of stroke. This has motivated researchers to explore the use of robotic devices to provide rehabilitation therapy for strokepatients. This paper reviews the recent progress of upper limb exoskeleton robots for rehabilitation treatment of patients with neuromuscular disorders. Firstly, a brief introduction to rehabilitation robots will be given along with examples of existing commercial devices. The advancements in upper limb exoskeleton technology and the fundamental challenges in developing these devices are described. Potential areas for future research are discussed. Copyright © 2011 IPEM. Published by Elsevier Ltd. All rights reserved.

Carbon-nanotube-based liquids: a new class of nanomaterials and their applications

NASA Astrophysics Data System (ADS)

Phan, Ngoc Minh; Thang Bui, Hung; Nguyen, Manh Hong; Khoi Phan, Hong

2014-03-01

Carbon-nanotube-based liquids—a new class of nanomaterials—have shown many interesting properties and distinctive features offering unprecedented potential for many applications. This paper summarizes the recent progress on the study of the preparation, characterization and properties of carbon-nanotube-based liquids including so-called nanofluids, nanolubricants and different kinds of nanosolutions containing multi-walled carbon nanotubes/single-walled carbon nanotubes/graphene. A broad range of current and future applications of these nanomaterials in the fields of energy saving, power electronic and optoelectronic devices, biotechnology and agriculture are presented. The paper also identifies challenges and opportunities for future research.

Nano-technology contributions towards the development of high performance radioisotope generators: The future promise to meet the continuing clinical demand.

PubMed

Sakr, Tamer M; Nawar, Mohamed F; Fasih, T W; El-Bayoumy, S; Abd El-Rehim, H A

2017-11-01

Nanostructured materials attracted considerable attention because of its high surface area to volume ratio resulting from their nano-scale dimensions. This class of sorbents is expected to have a potential impact on enhancement the efficacy of radioisotope generators for diagnostic and therapeutic applications in nuclear medicine. This review provides a summary on the importance of nanostructured materials as effective sorbents for the development of clinical-scale radioisotope generators and outlining the assessment of recent developments, key challenges and promising access to the near future. Copyright © 2017 Elsevier Ltd. All rights reserved.

Precise and traceable carbon isotope ratio measurements by multicollector ICP-MS: what next?

PubMed

Santamaria-Fernandez, Rebeca

2010-06-01

This article reviews recent developments in the use of multicollector inductively coupled plasma mass spectrometry (MC-ICP-MS) to provide high-precision carbon isotope ratio measurements. MC-ICP-MS could become an alternative method to isotope ratio mass spectrometry (IRMS) for rapid carbon isotope ratio determinations in organic compounds and characterisation and certification of isotopic reference materials. In this overview, the advantages, drawbacks and potential of the method for future applications are critically discussed. Furthermore, suggestions for future improvements in terms of precision and sensitivity are made. No doubt, this is an exciting analytical challenge and, as such, hurdles will need to be cleared.

A synergistic glance at the prospects of distributed propulsion technology and the electric aircraft concept for future unmanned air vehicles and commercial/military aviation

NASA Astrophysics Data System (ADS)

Gohardani, Amir S.

2013-02-01

Distributed propulsion is one of the revolutionary candidates for future aircraft propulsion. In this journal article, the potential role of distributed propulsion technology in future aviation is investigated. Following a historical journey that revisits distributed propulsion technology in unmanned air vehicles and military aircraft, features of this specific technology are highlighted in synergy with an electric aircraft concept and a first-of-a-kind comparison to commercial aircraft employing distributed propulsion arrangements. In light of propulsion-airframe integration and complementary technologies such as boundary layer ingestion, thrust vectoring and circulation control, transpired opportunities and challenges are addressed in addition to a number of identified research directions proposed for future aircraft. The motivation behind enhanced means of communication between engineers, researchers and scientists has stimulated a novel proposed definition for the distributed propulsion technology in aviation and is presented herein.

Identification of Crew-Systems Interactions and Decision Related Trends

NASA Technical Reports Server (NTRS)

Jones, Sharon Monica; Evans, Joni K.; Reveley, Mary S.; Withrow, Colleen A.; Ancel, Ersin; Barr, Lawrence

2013-01-01

NASA Vehicle System Safety Technology (VSST) project management uses systems analysis to identify key issues and maintain a portfolio of research leading to potential solutions to its three identified technical challenges. Statistical data and published safety priority lists from academic, industry and other government agencies were reviewed and analyzed by NASA Aviation Safety Program (AvSP) systems analysis personnel to identify issues and future research needs related to one of VSST's technical challenges, Crew Decision Making (CDM). The data examined in the study were obtained from the National Transportation Safety Board (NTSB) Aviation Accident and Incident Data System, Federal Aviation Administration (FAA) Accident/Incident Data System and the NASA Aviation Safety Reporting System (ASRS). In addition, this report contains the results of a review of safety priority lists, information databases and other documented references pertaining to aviation crew systems issues and future research needs. The specific sources examined were: Commercial Aviation Safety Team (CAST) Safety Enhancements Reserved for Future Implementation (SERFIs), Flight Deck Automation Issues (FDAI) and NTSB Most Wanted List and Open Recommendations. Various automation issues taxonomies and priority lists pertaining to human factors, automation and flight design were combined to create a list of automation issues related to CDM.

Medically assisted reproduction and ethical challenges

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kaeaeriaeinen, Helena; Evers-Kiebooms, Gerry; Coviello, Domenico

2005-09-01

Many of the ethical challenges associated with medically assisted reproduction are societal. Should the technique be restricted to only ordinary couples or could it be used also to single females or couples of same sex? Should the future child be entitled to know the identity of the gamete donor? Should there be age limits? Can embryos or gametes be used after the death of the donor? Can surrogate mothers be part of the process? Can preimplantation diagnostics be used to select the future baby's sex? In addition, there are several clearly medical questions that lead to difficult ethical problems. Ismore » it safe to use very premature eggs or sperms? Is the risk for some rare syndromes caused by imprinting errors really increased when using these techniques? Do we transfer genetic infertility to the offspring? Is the risk for multiple pregnancies too high when several embryos are implanted? Does preimplantation diagnosis cause some extra risks for the future child? Should the counselling of these couples include information of all these potential but unlikely risks? The legislation and practices differ in different countries and ethical discussion and professional guidelines are still needed.« less

Nanotechnology Applications in Functional Foods; Opportunities and Challenges.

PubMed

Singh, Harjinder

2016-03-01

Increasing knowledge on the link between diet and human health has generated a lot of interest in the development of functional foods. However, several challenges, including discovering of beneficial compounds, establishing optimal intake levels, and developing adequate food delivering matrix and product formulations, need to be addressed. A number of new processes and materials derived from nanotechnology have the potential to provide new solutions in many of these fronts. Nanotechnology is concerned with the manipulation of materials at the atomic and molecular scales to create structures that are less than 100 nm in size in one dimension. By carefully choosing the molecular components, it seems possible to design particles with different surface properties. Several food-based nanodelivery vehicles, such as protein-polysaccharide coacervates, multiple emulsions, liposomes and cochleates have been developed on a laboratory scale, but there have been very limited applications in real food systems. There are also public concerns about potential negative effects of nanotechnology-based delivery systems on human health. This paper provides an overview of the new opportunities and challenges for nanotechnology-based systems in future functional food development.

Challenges in Accommodating Volume Change of Si Anodes for Li-Ion Batteries

PubMed Central

Ko, Minseong; Chae, Sujong; Cho, Jaephil

2015-01-01

Si has been considered as a promising alternative anode for next-generation Li-ion batteries (LIBs) because of its high theoretical energy density, relatively low working potential, and abundance in nature. However, Si anodes exhibit rapid capacity decay and an increase in the internal resistance, which are caused by the large volume changes upon Li insertion and extraction. This unfortunately limits their practical applications. Therefore, managing the total volume change remains a critical challenge for effectively alleviating the mechanical fractures and instability of solid-electrolyte-interphase products. In this regard, we review the recent progress in volume-change-accommodating Si electrodes and investigate their ingenious structures with significant improvements in the battery performance, including size-controlled materials, patterned thin films, porous structures, shape-preserving shell designs, and graphene composites. These representative approaches potentially overcome the large morphologic changes in the volume of Si anodes by securing the strain relaxation and structural integrity in the entire electrode. Finally, we propose perspectives and future challenges to realize the practical application of Si anodes in LIB systems. PMID:27525208

Ethical challenges in developing an educational video to empower potential participants during consent processes in HIV cure research in South Africa.

PubMed

Staunton, Ciara; de Roubaix, Malcolm; Baatjies, Dianno; Black, Gill; Hendricks, Melany; Rossouw, Theresa; Moodley, Keymanthri

2018-04-01

Obtaining consent for HIV research is complex, particularly in low- and middle-income countries. Low levels of education, complexity of science and research processes, confusion about basic elements of research, and socio-economic conditions that make access to medical care difficult have collectively led to concerns about the adequacy of the consent process. Given the exponential growth of HIV prevention and treatment research in South Africa, HIV researchers are increasingly facing challenges obtaining authentic informed consent from potential participants. It is anticipated that HIV cure research, despite being in its infancy in South Africa, will introduce a new discourse into a population that is often struggling to understand the differences between 'cure', 'preventive and therapeutic vaccines' and other elements of the research process. Coupled with this, South Africa has a complex history of 'illegitimate' or 'false cures' for HIV. It is therefore logical to anticipate that HIV cure research may face significant challenges during consent processes. HIV prevention research in South Africa has demonstrated the importance of early community engagement in educating potential research participants and promoting community acceptance of research. Consequently, in an attempt to extrapolate from this experience of engaging with communities early regarding cure research, a 15-minute educational video entitled ' I have a dream: a world without HIV ' was developed to educate and ultimately empower potential research participants to make informed choices during consent processes in future HIV cure clinical trials. To aid others in the development of educational interventions, this paper discusses the challenges faced in developing this educational video.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kumar, Gyanendra; Swaminathan, Subramanyam

Botulinum Neurotoxins are the most poisonous of all toxins with lethal dose in nanogram quantities. They are also potential biological warfare and bioterrorism agents due to their high toxicity and ease of preparation. On the other hand BoNTs are also being increasingly used for therapeutic and cosmetic purposes, and with that the chances of accidental overdose are increasing. And despite the potential damage they could cause to human health, there are no post-intoxication drugs available so far. But progress is being made in this direction. The crystal structures in native form and bound with substrate peptides have been determined, andmore » these are enabling structure-based drug discovery possible. High throughput assays have also been designed to speed up the screening progress. Substrate-based and small molecule inhibitors have been identified. But turning high affinity inhibitors into clinically viable drug candidates has remained a challenge. We discuss here the latest developments and the future challenges in drug discovery for Botulinum neurotoxins.« less

Achieving the health Millennium Development Goals for South Africa: challenges and priorities.

PubMed

Chopra, Mickey; Lawn, Joy E; Sanders, David; Barron, Peter; Abdool Karim, Salim S; Bradshaw, Debbie; Jewkes, Rachel; Abdool Karim, Quarraisha; Flisher, Alan J; Mayosi, Bongani M; Tollman, Stephen M; Churchyard, Gavin J; Coovadia, Hoosen

2009-09-19

15 years after liberation from apartheid, South Africans are facing new challenges for which the highest calibre of leadership, vision, and commitment is needed. The effect of the unprecedented HIV/AIDS epidemic has been immense. Substantial increases in mortality and morbidity are threatening to overwhelm the health system and undermine the potential of South Africa to attain the Millennium Development Goals (MDGs). However The Lancet's Series on South Africa has identified several examples of leadership and innovation that point towards a different future scenario. We discuss the type of vision, leadership, and priority actions needed to achieve such a change. We still have time to change the health trajectory of the country, and even meet the MDGs. The South African Government, installed in April, 2009, has the mandate and potential to address the public health emergencies facing the country--will they do so or will another opportunity and many more lives be lost?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cheng, Shiwang; Xie, Shi-Jie; Carrillo, Jan-Michael Y.

Polymer nanocomposites (PNCs) are important materials that are widely used in many current technologies and potentially have broader applications in the future due to their excellent property of tunability, light weight and low cost. But, expanding the limits in property enhancement remains a fundamental scientific challenge. We demonstrate that well-dispersed, small (diameter ~1.8 nm) nanoparticles with attractive interactions lead to unexpectedly large and qualitatively new changes in PNC structural dynamics in comparison to conventional composites based on particles of diameter ~10-50 nm. At the same time, the zero-shear viscosity at high temperatures remains comparable to that of the neat polymer,more » thereby retaining good processibility and resolving a major challenge in PNC applications. These results suggest that the nanoparticle mobility and relatively short lifetimes of nanoparticlepolymer associations open qualitatively new horizons in tunability of macroscopic properties in nanocomposites with high potential for the development of new functional materials.« less

Co-Optimization of Internal Combustion Engines and Biofuels

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCormick, Robert L.

2016-03-08

The development of advanced engines has significant potential advantages in reduced aftertreatment costs for air pollutant emission control, and just as importantly for efficiency improvements and associated greenhouse gas emission reductions. There are significant opportunities to leverage fuel properties to create more optimal engine designs for both advanced spark-ignition and compression-ignition combustion strategies. The fact that biofuel blendstocks offer a potentially low-carbon approach to fuel production, leads to the idea of optimizing the entire fuel production-utilization value chain as a system from the standpoint of life cycle greenhouse gas emissions. This is a difficult challenge that has yet to bemore » realized. This presentation will discuss the relationship between chemical structure and critical fuel properties for more efficient combustion, survey the properties of a range of biofuels that may be produced in the future, and describe the ongoing challenges of fuel-engine co-optimization.« less

Electroactive polymer (EAP) actuators for future humanlike robots

NASA Astrophysics Data System (ADS)

Bar-Cohen, Yoseph

2009-03-01

Human-like robots are increasingly becoming an engineering reality thanks to recent technology advances. These robots, which are inspired greatly by science fiction, were originated from the desire to reproduce the human appearance, functions and intelligence and they may become our household appliance or even companion. The development of such robots is greatly supported by emerging biologically inspired technologies. Potentially, electroactive polymer (EAP) materials are offering actuation capabilities that allow emulating the action of our natural muscles for making such machines perform lifelike. There are many technical issues related to making such robots including the need for EAP materials that can operate as effective actuators. Beside the technology challenges these robots also raise concerns that need to be addressed prior to forming super capable robots. These include the need to prevent accidents, deliberate harm, or their use in crimes. In this paper, the potential EAP actuators and the challenges that these robots may pose will be reviewed.

Challenges and perspectives of garnet solid electrolytes for all solid-state lithium batteries

NASA Astrophysics Data System (ADS)

Liu, Qi; Geng, Zhen; Han, Cuiping; Fu, Yongzhu; Li, Song; He, Yan-bing; Kang, Feiyu; Li, Baohua

2018-06-01

Garnet Li7La3Zr2O12 (LLZO) solid electrolytes recently have attracted tremendous interest as they have the potential to enable all solid-state lithium batteries (ASSLBs) owing to high ionic conductivity (10-3 to 10-4 S cm-1), negligible electronic transport, wide potential window (up to 9 V), and good chemical stability. Here we present the key issues and challenges of LLZO in the aspects of ion conduction property, interfacial compatibility, and stability in air. First, different preparation methods of LLZO are reviewed. Then, recent progress about the improvement of ionic conductivity and interfacial property between LLZO and electrodes are presented. Finally, we list some emerging LLZO-based solid-state batteries and provide perspectives for further research. The aim of this review is to summarize the up-to-date developments of LLZO and lead the direction for future development which could enable LLZO-based ASSLBs.

EEG-Based Brain–Computer Interfaces for Communication and Rehabilitation of People with Motor Impairment: A Novel Approach of the 21st Century

PubMed Central

Lazarou, Ioulietta; Nikolopoulos, Spiros; Petrantonakis, Panagiotis C.; Kompatsiaris, Ioannis; Tsolaki, Magda

2018-01-01

People with severe neurological impairments face many challenges in sensorimotor functions and communication with the environment; therefore they have increased demand for advanced, adaptive and personalized rehabilitation. During the last several decades, numerous studies have developed brain–computer interfaces (BCIs) with the goals ranging from providing means of communication to functional rehabilitation. Here we review the research on non-invasive, electroencephalography (EEG)-based BCI systems for communication and rehabilitation. We focus on the approaches intended to help severely paralyzed and locked-in patients regain communication using three different BCI modalities: slow cortical potentials, sensorimotor rhythms and P300 potentials, as operational mechanisms. We also review BCI systems for restoration of motor function in patients with spinal cord injury and chronic stroke. We discuss the advantages and limitations of these approaches and the challenges that need to be addressed in the future. PMID:29472849

Electroactive Polymer (EAP) Actuators for Future Humanlike Robots

NASA Technical Reports Server (NTRS)

Bar-Cohen, Yoseph

2009-01-01

Human-like robots are increasingly becoming an engineering reality thanks to recent technology advances. These robots, which are inspired greatly by science fiction, were originated from the desire to reproduce the human appearance, functions and intelligence and they may become our household appliance or even companion. The development of such robots is greatly supported by emerging biologically inspired technologies. Potentially, electroactive polymer (EAP) materials are offering actuation capabilities that allow emulating the action of our natural muscles for making such machines perform lifelike. There are many technical issues related to making such robots including the need for EAP materials that can operate as effective actuators. Beside the technology challenges these robots also raise concerns that need to be addressed prior to forming super capable robots. These include the need to prevent accidents, deliberate harm, or their use in crimes. In this paper, the potential EAP actuators and the challenges that these robots may pose will be reviewed.

Microbial synthesis gas utilization and ways to resolve kinetic and mass-transfer limitations.

PubMed

Yasin, Muhammad; Jeong, Yeseul; Park, Shinyoung; Jeong, Jiyeong; Lee, Eun Yeol; Lovitt, Robert W; Kim, Byung Hong; Lee, Jinwon; Chang, In Seop

2015-02-01

Microbial conversion of syngas to energy-dense biofuels and valuable chemicals is a potential technology for the efficient utilization of fossils (e.g., coal) and renewable resources (e.g., lignocellulosic biomass) in an environmentally friendly manner. However, gas-liquid mass transfer and kinetic limitations are still major constraints that limit the widespread adoption and successful commercialization of the technology. This review paper provides rationales for syngas bioconversion and summarizes the reaction limited conditions along with the possible strategies to overcome these challenges. Mass transfer and economic performances of various reactor configurations are compared, and an ideal case for optimum bioreactor operation is presented. Overall, the challenges with the bioprocessing steps are highlighted, and potential solutions are suggested. Future research directions are provided and a conceptual design for a membrane-based syngas biorefinery is proposed. Copyright © 2014 Elsevier Ltd. All rights reserved.

Impact of the Health Insurance Portability and Accountability Act on participant recruitment and retention.

PubMed

Wipke-Tevis, Deidre D; Pickett, Melissa A

2008-02-01

Recruiting and retaining an adequate sample is critical to the success of any research project involving humans. Recent reports indicate that the Health Insurance Portability and Accountability Act (HIPAA) privacy rule has adversely affected research. Few resources are available to help researchers navigate the challenges to recruitment and retention after HIPAA privacy rule implementation. This article addresses obstacles to recruitment in prospective clinical research studies related to the HIPAA privacy rule, as well as HIPAA-compliant strategies to enhance recruitment and retention. Recruitment challenges discussed include evolving interpretations of the HIPAA regulations, inability to directly contact potential participants, complexity of HIPAA-required documents, increased costs of recruitment, and an expanding administrative burden. Among the strategies addressed are preparatory research reviews, using clinical collaborators and staff liaisons, prescreening potential participants, minimizing participant burden during the consent process, enhancing participant follow-up, facilitating recruitment for future studies, and streamlining compliance training for staff.

Fundamental challenges to methane recovery from gas hydrates

USGS Publications Warehouse

Servio, P.; Eaton, M.W.; Mahajan, D.; Winters, W.J.

2005-01-01

The fundamental challenges, the location, magnitude, and feasibility of recovery, which must be addressed to recover methane from dispersed hydrate sources, are presented. To induce dissociation of gas hydrate prior to methane recovery, two potential methods are typically considered. Because thermal stimulation requires a large energy input, it is less economically feasible than depressurization. The new data will allow the study of the effect of pressure, temperature, diffusion, porosity, tortuosity, composition of gas and water, and porous media on gas-hydrate production. These data also will allow one to improve existing models related to the stability and dissociation of sea floor hydrates. The reproducible kinetic data from the planned runs together with sediment properties will aid in developing a process to economically recover methane from a potential untapped hydrate source. The availability of plentiful methane will allow economical and large-scale production of methane-derived clean fuels to help avert future energy crises.

Millimetre-Wave Backhaul for 5G Networks: Challenges and Solutions.

PubMed

Feng, Wei; Li, Yong; Jin, Depeng; Su, Li; Chen, Sheng

2016-06-16

The trend for dense deployment in future 5G mobile communication networks makes current wired backhaul infeasible owing to the high cost. Millimetre-wave (mm-wave) communication, a promising technique with the capability of providing a multi-gigabit transmission rate, offers a flexible and cost-effective candidate for 5G backhauling. By exploiting highly directional antennas, it becomes practical to cope with explosive traffic demands and to deal with interference problems. Several advancements in physical layer technology, such as hybrid beamforming and full duplexing, bring new challenges and opportunities for mm-wave backhaul. This article introduces a design framework for 5G mm-wave backhaul, including routing, spatial reuse scheduling and physical layer techniques. The associated optimization model, open problems and potential solutions are discussed to fully exploit the throughput gain of the backhaul network. Extensive simulations are conducted to verify the potential benefits of the proposed method for the 5G mm-wave backhaul design.

Defect-Engineered Metal–Organic Frameworks

PubMed Central

Fang, Zhenlan; Bueken, Bart; De Vos, Dirk E; Fischer, Roland A

2015-01-01

Defect engineering in metal–organic frameworks (MOFs) is an exciting concept for tailoring material properties, which opens up novel opportunities not only in sorption and catalysis, but also in controlling more challenging physical characteristics such as band gap as well as magnetic and electrical/conductive properties. It is challenging to structurally characterize the inherent or intentionally created defects of various types, and there have so far been few efforts to comprehensively discuss these issues. Based on selected reports spanning the last decades, this Review closes that gap by providing both a concise overview of defects in MOFs, or more broadly coordination network compounds (CNCs), including their classification and characterization, together with the (potential) applications of defective CNCs/MOFs. Moreover, we will highlight important aspects of “defect-engineering” concepts applied for CNCs, also in comparison with relevant solid materials such as zeolites or COFs. Finally, we discuss the future potential of defect-engineered CNCs. PMID:26036179

Methodological Issues in the Collection, Analysis, and Reporting of Granular Data in Asian American Populations: Historical Challenges and Potential Solutions

PubMed Central

Islam, Nadia Shilpi; Khan, Suhaila; Kwon, Simona; Jang, Deeana; Ro, Marguerite; Trinh-Shevrin, Chau

2011-01-01

There are close to 15 million Asian Americans living in the United States, and they represent the fastest growing populations in the country. By the year 2050, there will be an estimated 33.4 million Asian Americans living in the country. However, their health needs remain poorly understood and there is a critical lack of data disaggregated by Asian American ethnic subgroups, primary language, and geography. This paper examines methodological issues, challenges, and potential solutions to addressing the collection, analysis, and reporting of disaggregated (or, granular) data on Asian Americans. The article explores emerging efforts to increase granular data through the use of innovative study design and analysis techniques. Concerted efforts to implement these techniques will be critical to the future development of sound research, health programs, and policy efforts targeting this and other minority populations. PMID:21099084

Skeletal Muscle Ultrasound in Critical Care: A Tool in Need of Translation.

PubMed

Mourtzakis, Marina; Parry, Selina; Connolly, Bronwen; Puthucheary, Zudin

2017-10-01

With the emerging interest in documenting and understanding muscle atrophy and function in critically ill patients and survivors, ultrasonography has transformational potential for measurement of muscle quantity and quality. We discuss the importance of quantifying skeletal muscle in the intensive care unit setting. We also identify the merits and limitations of various modalities that are capable of accurately and precisely measuring muscularity. Ultrasound is emerging as a potentially powerful tool for skeletal muscle quantification; however, there are key challenges that need to be addressed in future work to ensure useful interpretation and comparability of results across diverse observational and interventional studies. Ultrasound presents several methodological challenges, and ultimately muscle quantification combined with metabolic, nutritional, and functional markers will allow optimal patient assessment and prognosis. Moving forward, we recommend that publications include greater detail on landmarking, repeated measures, identification of muscle that was not assessable, and reproducible protocols to more effectively compare results across different studies.

Western water and climate change.

PubMed

Dettinger, Michael; Udall, Bradley; Georgakakos, Aris

2015-12-01

The western United States is a region long defined by water challenges. Climate change adds to those historical challenges, but does not, for the most part, introduce entirely new challenges; rather climate change is likely to stress water supplies and resources already in many cases stretched to, or beyond, natural limits. Projections are for continued and, likely, increased warming trends across the region, with a near certainty of continuing changes in seasonality of snowmelt and streamflows, and a strong potential for attendant increases in evaporative demands. Projections of future precipitation are less conclusive, although likely the northern-most West will see precipitation increases while the southernmost West sees declines. However, most of the region lies in a broad area where some climate models project precipitation increases while others project declines, so that only increases in precipitation uncertainties can be projected with any confidence. Changes in annual and seasonal hydrographs are likely to challenge water managers, users, and attempts to protect or restore environmental flows, even where annual volumes change little. Other impacts from climate change (e.g., floods and water-quality changes) are poorly understood and will likely be location dependent. In this context, four iconic river basins offer glimpses into specific challenges that climate change may bring to the West. The Colorado River is a system in which overuse and growing demands are projected to be even more challenging than climate-change-induced flow reductions. The Rio Grande offers the best example of how climate-change-induced flow declines might sink a major system into permanent drought. The Klamath is currently projected to face the more benign precipitation future, but fisheries and irrigation management may face dire straits due to warming air temperatures, rising irrigation demands, and warming waters in a basin already hobbled by tensions between endangered fisheries and agricultural demands. Finally, California's Bay-Delta system is a remarkably localized and severe weakness at the heart of the region's trillion-dollar economy. It is threatened by the full range of potential climate-change impacts expected across the West, along with major vulnerabilities to increased flooding and rising sea levels.

Non-Invasive Gene Therapy of Experimental Parkinson’s Disease

DTIC Science & Technology

2006-09-01

Dejneka NS, Bennett J. Gene therapy and retinitis pigmentosa : advances and future challenges. Bioessays 2001; 23:662-8. 3. Hauswirth WW, McInnes RR...NM_001940 Blindness Retinitis pigmentosa -1 RHO NM_000539 Peripherin-related retinal degeneration RDS NM_000322 Gyrate atrophy OAT NM_000274 CNS tumor...September 2003 | Published 3 October 2003 Many forms of blindness are potentially treatable with retinal gene therapy [1,2]. The retinal

Intermetallic compounds in heterogeneous catalysis—a quickly developing field

PubMed Central

Armbrüster, Marc; Schlögl, Robert; Grin, Yuri

2014-01-01

The application of intermetallic compounds for understanding in heterogeneous catalysis developed in an excellent way during the last decade. This review provides an overview of concepts and developments revealing the potential of intermetallic compounds in fundamental as well as applied catalysis research. Intermetallic compounds may be considered as platform materials to address current and future catalytic challenges, e.g. in respect to the energy transition. PMID:27877674

Unfolding the Future of the Long War: Motivations, Prospects, and Implications for the U.S. Army

DTIC Science & Technology

2008-01-01

chauvinism for its legitimacy. State-Centric State-Centric aims to spread effective governance throughout the Muslim world by strengthening...involvement in the region during times of sectarian violence would challenge IO capabilities to aid in discrediting arguments and propaganda of...quent extensions of the framework to other potential interpretations, have formed the bases for arguments both in support of and against the

Listening to Historys Rhyme:Preparing the United States Army for Future Irregular Warfare

DTIC Science & Technology

2014-04-01

of the most likely, which typically results in developing technologically advanced, conventional solutions to potential rivals, options poorly...What makes hybrid wars so challenging is that different elements execute the various modes of warfare and are typically coordinated at various... Morocco to train its forces on logistics, combined arms maneuver, and other skills. 72 Atlas Accord is a new exercise started in 2012 to provide

GMO quantification: valuable experience and insights for the future.

PubMed

Milavec, Mojca; Dobnik, David; Yang, Litao; Zhang, Dabing; Gruden, Kristina; Zel, Jana

2014-10-01

Cultivation and marketing of genetically modified organisms (GMOs) have been unevenly adopted worldwide. To facilitate international trade and to provide information to consumers, labelling requirements have been set up in many countries. Quantitative real-time polymerase chain reaction (qPCR) is currently the method of choice for detection, identification and quantification of GMOs. This has been critically assessed and the requirements for the method performance have been set. Nevertheless, there are challenges that should still be highlighted, such as measuring the quantity and quality of DNA, and determining the qPCR efficiency, possible sequence mismatches, characteristics of taxon-specific genes and appropriate units of measurement, as these remain potential sources of measurement uncertainty. To overcome these problems and to cope with the continuous increase in the number and variety of GMOs, new approaches are needed. Statistical strategies of quantification have already been proposed and expanded with the development of digital PCR. The first attempts have been made to use new generation sequencing also for quantitative purposes, although accurate quantification of the contents of GMOs using this technology is still a challenge for the future, and especially for mixed samples. New approaches are needed also for the quantification of stacks, and for potential quantification of organisms produced by new plant breeding techniques.

Recent Advances of MEMS Resonators for Lorentz Force Based Magnetic Field Sensors: Design, Applications and Challenges.

PubMed

Herrera-May, Agustín Leobardo; Soler-Balcazar, Juan Carlos; Vázquez-Leal, Héctor; Martínez-Castillo, Jaime; Vigueras-Zuñiga, Marco Osvaldo; Aguilera-Cortés, Luz Antonio

2016-08-24

Microelectromechanical systems (MEMS) resonators have allowed the development of magnetic field sensors with potential applications such as biomedicine, automotive industry, navigation systems, space satellites, telecommunications and non-destructive testing. We present a review of recent magnetic field sensors based on MEMS resonators, which operate with Lorentz force. These sensors have a compact structure, wide measurement range, low energy consumption, high sensitivity and suitable performance. The design methodology, simulation tools, damping sources, sensing techniques and future applications of magnetic field sensors are discussed. The design process is fundamental in achieving correct selection of the operation principle, sensing technique, materials, fabrication process and readout systems of the sensors. In addition, the description of the main sensing systems and challenges of the MEMS sensors are discussed. To develop the best devices, researches of their mechanical reliability, vacuum packaging, design optimization and temperature compensation circuits are needed. Future applications will require multifunctional sensors for monitoring several physical parameters (e.g., magnetic field, acceleration, angular ratio, humidity, temperature and gases).

Deep Space Mission Trend Analyses: A Briefing to the Next Generation EBRE Study Team

NASA Technical Reports Server (NTRS)

Abraham, Douglas S.

2012-01-01

Determination of stakeholder needs for next generation implementations necessitates a multi ]pronged approach. . Future mission set analyses provide a lower gbound h for some of these needs. . Earth ]based analogies provide an upper gbound h for some of these needs. . Interpreting the results requires being mindful of both the near ]term contextual factors and long ]term factors that are in play. . In the context of last year fs analyses, the current budget environment, the potential Pu ]238 shortage, and SMD fs gsingle 34m only h policy may, collectively, create a future deep space mission set that, from a capacity and end ]to ]end link difficulty standpoint, is no more challenging than it is today. . Nonetheless, data rates and volumes continue to increase, suggesting capability and spectrum challenges ahead. These results agree with the results from the Earthbased analogies. . Emerging developments such as smallsats and distributed spacecraft could significantly change the capacity and end ]to ]end link difficulty picture.

Recent Advances of MEMS Resonators for Lorentz Force Based Magnetic Field Sensors: Design, Applications and Challenges

PubMed Central

Herrera-May, Agustín Leobardo; Soler-Balcazar, Juan Carlos; Vázquez-Leal, Héctor; Martínez-Castillo, Jaime; Vigueras-Zuñiga, Marco Osvaldo; Aguilera-Cortés, Luz Antonio

2016-01-01

Microelectromechanical systems (MEMS) resonators have allowed the development of magnetic field sensors with potential applications such as biomedicine, automotive industry, navigation systems, space satellites, telecommunications and non-destructive testing. We present a review of recent magnetic field sensors based on MEMS resonators, which operate with Lorentz force. These sensors have a compact structure, wide measurement range, low energy consumption, high sensitivity and suitable performance. The design methodology, simulation tools, damping sources, sensing techniques and future applications of magnetic field sensors are discussed. The design process is fundamental in achieving correct selection of the operation principle, sensing technique, materials, fabrication process and readout systems of the sensors. In addition, the description of the main sensing systems and challenges of the MEMS sensors are discussed. To develop the best devices, researches of their mechanical reliability, vacuum packaging, design optimization and temperature compensation circuits are needed. Future applications will require multifunctional sensors for monitoring several physical parameters (e.g., magnetic field, acceleration, angular ratio, humidity, temperature and gases). PMID:27563912

The development of marine renewable energy in China: prospects, challenges and recommendations

NASA Astrophysics Data System (ADS)

Wang, Ji; Wang, Haifeng; Liu, Yuxin; Chen, Libo; Tang, Jiuting

2018-02-01

In this paper, resources distribution and technology status of tidal energy, wave energy, tidal current energy, ocean thermal energy and salinity gradient energy in China is reviewed, and assessment and advices are given for each category. By analysis, we believe that marine renewable energy is a necessary addition to existent renewable energy to meet the energy demand of the areas and islands where traditional forms of energy are not applicable and it is of great importance in adjusting energy structure of China. This paper describes the potential of marine renewable energy in China, and explores the possible role in future energy systems. As the paper discusses, building on these initiatives, and “realizing” the accelerated development of marine energy, presents a number of challenges. This paper describes a scenario for the accelerated development of marine renewable energy in China from now to 2030. Finally, this paper provides recommendations for future development of marine renewable energy in China.

Designing the future: NBIC technologies and human performance enhancement.

PubMed

Canton, James

2004-05-01

Never before has any civilization had the unique opportunity to enhance human performance on the scale that we will face in the near future. The convergence of nanotechnology, biotechnology, information technology, and cognitive science (NBIC) is creating a set of powerful tools that have the potential to significantly enhance human performance as well as transform society, science, economics, and human evolution. As the NBIC convergence becomes more understood, the possibility that we may be able to enhance human performance in the three domains of therapy, augmentation, and designed evolution will become anticipated and even expected. In addition, NBIC convergence represents entirely new challenges for scientists, policymakers, and business leaders who will have, for the first time, vast new and powerful tools to shape markets, societies, and lifestyles. The emergence of NBIC convergence will challenge us in new ways to balance risk and return, threat and opportunity, and social responsibility and competitive advantage as we step into the 21st century.

Challenges and future in vaccines, drug development, and immunomodulatory therapy.

PubMed

Kling, Heather M; Nau, Gerard J; Ross, Ted M; Evans, Thomas G; Chakraborty, Krishnendu; Empey, Kerry M; Flynn, JoAnne L

2014-08-01

Pulmonary diseases and infections are among the top contributors to human morbidity and mortality worldwide, and despite the successful history of vaccines and antimicrobial therapeutics, infectious disease still presents a significant threat to human health. Effective vaccines are frequently unavailable in developing countries, and successful vaccines have yet to be developed for major global maladies, such as tuberculosis. Furthermore, antibiotic resistance poses a growing threat to human health. The "Challenges and Future in Vaccines, Drug Development, and Immunomodulatory Therapy" session of the 2013 Pittsburgh International Lung Conference highlighted several recent and current studies related to treatment and prevention of antibiotic-resistant bacterial infections, highly pathogenic influenza, respiratory syncytial virus, and tuberculosis. Research presented here focused on novel antimicrobial therapies, new vaccines that are either in development or currently in clinical trials, and the potential for immunomodulatory therapies. These studies are making important contributions to the areas of microbiology, virology, and immunology related to pulmonary diseases and infections and are paving the way for improvements in the efficacy of vaccines and antimicrobials.

'The medical' and 'health' in a critical medical humanities.

PubMed

Atkinson, Sarah; Evans, Bethan; Woods, Angela; Kearns, Robin

2015-03-01

As befits an emerging field of enquiry, there is on-going discussion about the scope, role and future of the medical humanities. One relatively recent contribution to this debate proposes a differentiation of the field into two distinct terrains, 'medical humanities' and 'health humanities,' and calls for a supersession of the former by the latter. In this paper, we revisit the conceptual underpinnings for a distinction between 'the medical' and 'health' by looking at the history of an analogous debate between 'medical geography' and 'the geographies of health' that has, over the last few years, witnessed a re-blurring of the distinction. Highlighting the value of this debate within the social sciences for the future development of the medical humanities, we call for scholars to take seriously the challenges of critical and cultural theory, community-based arts and health, and the counter-cultural creative practices and strategies of activist movements in order to meet the new research challenges and fulfill the radical potential of a critical medical humanities.

Engineering challenges for detectors at the ILC

DOE PAGES

Oriunno, Marco

2016-05-31

Over the last years two proposals for experiments at the ILC have been developed, ILD and SID. Extensive R&D has been carried out around the world to develop the needed technologies. Furthermore a first round of engineering studies was made as part of the ILC TDR to understand the integration of these different sub-systems into coherent and integrated detector concepts. Among the key challenges for the sub detectors are the extreme low mass/low power requirements or the extreme channel densities needed in particle flow based detectors. Throughout these studies special care was taken to ensure that the engineering models andmore » the simulation models, used in studies of the physics capabilities of the detectors, stay synchronized. In the near future, the models will need to be evolved to take the special requirements of the potential ILC site in Japan into account. Furthermore, the state of the integration of the detectors, and the future directions, will be discussed.« less

Global health issues and challenges.

PubMed

Dickenson-Hazard, Nancy

2004-01-01

To describe issues, challenges and potential strategies in achieving nursing's global preferred future, focused on promoting healthy communities worldwide. Three sets of Arista conferences, a total of 7 conferences, were sponsored by Sigma Theta Tau International Honor Society of Nursing. Arista2 and Arista3--the focus of this report--were held in different world regions. A total of 109 invited multi-disciplinary participants identified conditions that affect nursing and health care, strategic actions to address those conditions, and recommendations for the nursing profession. Reports from each conference are synthesized in this executive summary. Both common and unique themes were identified in various world regions. Key components of the preferred future were professional restructuring and the delivery of holistic, human, and culturally appropriate care. Participants in all regional conferences recommended strategic actions regarding: student-centered educational systems, environments in which nurses practice, the way nurses lead, the knowledge nurses need, the settings in which nurses work, the conditions under which the profession operates, the influence of nurses, and the ways nurses learn.

Extracellular Matrix Scaffold Technology for Bioartificial Pancreas Engineering: State of the Art and Future Challenges.

PubMed

Salvatori, Marcus; Katari, Ravi; Patel, Timil; Peloso, Andrea; Mugweru, Jon; Owusu, Kofi; Orlando, Giuseppe

2014-01-01

Emergent technologies in regenerative medicine may soon overcome the limitations of conventional diabetes therapies. Collaborative efforts across the subfields of stem cell technology, islet encapsulation, and biomaterial carriers seek to produce a bioengineered pancreas capable of restoring endocrine function in patients with insulin-dependent diabetes. These technologies rely on a robust understanding of the extracellular matrix (ECM), the supportive 3-dimensional network of proteins necessary for cellular attachment, proliferation, and differentiation. Although these functions can be partially approximated by biosynthetic carriers, novel decellularization protocols have allowed researchers to discover the advantages afforded by the native pancreatic ECM. The native ECM has proven to be an optimal platform for recellularization and whole-organ pancreas bioengineering, an exciting new field with the potential to resolve the dire shortage of transplantable organs. This review seeks to contextualize recent findings, discuss current research goals, and identify future challenges of regenerative medicine as it applies to diabetes management. © 2014 Diabetes Technology Society.

Current Approaches, Challenges and Future Directions for Monitoring Treatment Response in Prostate Cancer

PubMed Central

Wallace, T.J.; Torre, T.; Grob, M.; Yu, J.; Avital, I.; Brücher, BLDM; Stojadinovic, A.; Man, Y.G.

2014-01-01

Prostate cancer is the most commonly diagnosed non-cutaneous neoplasm in men in the United States and the second leading cause of cancer mortality. One in 7 men will be diagnosed with prostate cancer during their lifetime. As a result, monitoring treatment response is of vital importance. The cornerstone of current approaches in monitoring treatment response remains the prostate-specific antigen (PSA). However, with the limitations of PSA come challenges in our ability to monitor treatment success. Defining PSA response is different depending on the individual treatment rendered potentially making it difficult for those not trained in urologic oncology to understand. Furthermore, standard treatment response criteria do not apply to prostate cancer further complicating the issue of treatment response. Historically, prostate cancer has been difficult to image and no single modality has been consistently relied upon to measure treatment response. However, with newer imaging modalities and advances in our understanding and utilization of specific biomarkers, the future for monitoring treatment response in prostate cancer looks bright. PMID:24396494

Seasonal Drought Prediction: Advances, Challenges, and Future Prospects

NASA Astrophysics Data System (ADS)

Hao, Zengchao; Singh, Vijay P.; Xia, Youlong

2018-03-01

Drought prediction is of critical importance to early warning for drought managements. This review provides a synthesis of drought prediction based on statistical, dynamical, and hybrid methods. Statistical drought prediction is achieved by modeling the relationship between drought indices of interest and a suite of potential predictors, including large-scale climate indices, local climate variables, and land initial conditions. Dynamical meteorological drought prediction relies on seasonal climate forecast from general circulation models (GCMs), which can be employed to drive hydrological models for agricultural and hydrological drought prediction with the predictability determined by both climate forcings and initial conditions. Challenges still exist in drought prediction at long lead time and under a changing environment resulting from natural and anthropogenic factors. Future research prospects to improve drought prediction include, but are not limited to, high-quality data assimilation, improved model development with key processes related to drought occurrence, optimal ensemble forecast to select or weight ensembles, and hybrid drought prediction to merge statistical and dynamical forecasts.

Exploring Nursing Students' Experiences of Learning Using Phenomenography: A Literature Review.

PubMed

Barry, Sinead; Ward, Louise; Walter, Ruby

2017-10-01

The purpose of this extensive international and national literature review was to explore how phenomenography identifies nursing students' experiences of learning within preregistration (or prelicensure) nursing education. Data were collected utilizing a comprehensive search of electronic databases. Full text, peer-reviewed, and scholarly articles published in English using the search terms phenomengraph*, nurs*, student, education, and learning were reviewed. Two discreet themes emerged exploring students' experiences of learning within preregistration nursing education: (a) Phenomenography was a beneficial method to expose variation in students' understandings of a challenging concept or topic and (b) phenomenography was beneficial to evaluate teaching methods in attempt to improve student learning of challenging and complex concepts. On the basis of these findings, future research utilizing phenomenography within nursing education has potential to uncover variation in students' understandings of mental health, with future consideration of implications to nursing curriculum design and development. [J Nurs Educ. 2017;56(10):591-598.]. Copyright 2017, SLACK Incorporated.

Trends in meat science and technology: the future looks bright, but the journey will be long.

PubMed

Kristensen, L; Støier, S; Würtz, J; Hinrichsen, L

2014-11-01

With an increasing world population, an increase in affluence and a substantial growth in the demand for high quality protein, the meat sector faces a fantastic but challenging century. New scientific knowledge, technology and creative minds are the main ingredients in order to reach out for this great opportunity. Efficiency all the way from breeding and farming to processing and dispatch is crucial for success. Technology has brought us far, and there is still a huge potential for increased efficiency by implementing best practices on a global scale. New challenges include: hyper flexible automation, more accurate and faster measurement systems and meeting special consumer demands already at the production line. Systems for optimal animal welfare will be even more important and sustainability is no longer a consumer trend but a license to operate. The scientific meat society must provide knowledge and technology so we together can reach out for a seemingly bright future. Copyright © 2014 Elsevier Ltd. All rights reserved.

The Future of Public Health Informatics: Alternative Scenarios and Recommended Strategies

PubMed Central

Edmunds, Margo; Thorpe, Lorna; Sepulveda, Martin; Bezold, Clem; Ross, David A.

2014-01-01

Background: In October 2013, the Public Health Informatics Institute (PHII) and Institute for Alternative Futures (IAF) convened a multidisciplinary group of experts to evaluate forces shaping public health informatics (PHI) in the United States, with the aim of identifying upcoming challenges and opportunities. The PHI workshop was funded by the Robert Wood Johnson Foundation as part of its larger strategic planning process for public health and primary care. Workshop Context: During the two-day workshop, nine experts from the public and private sectors analyzed and discussed the implications of four scenarios regarding the United States economy, health care system, information technology (IT) sector, and their potential impacts on public health in the next 10 years, by 2023. Workshop participants considered the potential role of the public health sector in addressing population health challenges in each scenario, and then identified specific informatics goals and strategies needed for the sector to succeed in this role. Recommendations and Conclusion: Participants developed recommendations for the public health informatics field and for public health overall in the coming decade. These included the need to rely more heavily on intersectoral collaborations across public and private sectors, to improve data infrastructure and workforce capacity at all levels of the public health enterprise, to expand the evidence base regarding effectiveness of informatics-based public health initiatives, and to communicate strategically with elected officials and other key stakeholders regarding the potential for informatics-based solutions to have an impact on population health. PMID:25848630

A review on the application of deep learning in system health management

NASA Astrophysics Data System (ADS)

Khan, Samir; Yairi, Takehisa

2018-07-01

Given the advancements in modern technological capabilities, having an integrated health management and diagnostic strategy becomes an important part of a system's operational life-cycle. This is because it can be used to detect anomalies, analyse failures and predict the future state based on up-to-date information. By utilising condition data and on-site feedback, data models can be trained using machine learning and statistical concepts. Once trained, the logic for data processing can be embedded on on-board controllers whilst enabling real-time health assessment and analysis. However, this integration inevitably faces several difficulties and challenges for the community; indicating the need for novel approaches to address this vexing issue. Deep learning has gained increasing attention due to its potential advantages with data classification and feature extraction problems. It is an evolving research area with diverse application domains and hence its use for system health management applications must been researched if it can be used to increase overall system resilience or potential cost benefits for maintenance, repair, and overhaul activities. This article presents a systematic review of artificial intelligence based system health management with an emphasis on recent trends of deep learning within the field. Various architectures and related theories are discussed to clarify its potential. Based on the reviewed work, deep learning demonstrates plausible benefits for fault diagnosis and prognostics. However, there are a number of limitations that hinder its widespread adoption and require further development. Attention is paid to overcoming these challenges, with future opportunities being enumerated.

Global Assessment of Exploitable Surface Reservoir Storage under Climate Change

NASA Astrophysics Data System (ADS)

Liu, L.; Parkinson, S.; Gidden, M.; Byers, E.; Satoh, Y.; Riahi, K.

2016-12-01

Surface water reservoirs provide us with reliable water supply systems, hydropower generation, flood control, and recreation services. Reliable reservoirs can be robust measures for water security and can help smooth out challenging seasonal variability of river flows. Yet, reservoirs also cause flow fragmentation in rivers and can lead to flooding of upstream areas, thereby displacing existing land-uses and ecosystems. The anticipated population growth, land use and climate change in many regions globally suggest a critical need to assess the potential for appropriate reservoir capacity that can balance rising demands with long-term water security. In this research, we assessed exploitable reservoir potential under climate change and human development constraints by deriving storage-yield relationships for 235 river basins globally. The storage-yield relationships map the amount of storage capacity required to meet a given water demand based on a 30-year inflow sequence. Runoff data is simulated with an ensemble of Global Hydrological Models (GHMs) for each of five bias-corrected general circulation models (GCMs) under four climate change pathways. These data are used to define future 30-year inflows in each river basin for time period between 2010 and 2080. The calculated capacity is then combined with geographical information of environmental and human development exclusion zones to further limit the storage capacity expansion potential in each basin. We investigated the reliability of reservoir potentials across different climate change scenarios and Shared Socioeconomic Pathways (SSPs) to identify river basins where reservoir expansion will be particularly challenging. Preliminary results suggest large disparities in reservoir potential across basins: some basins have already approached exploitable reserves, while some others display abundant potential. Exclusions zones pose significant impact on the amount of actual exploitable storage and firm yields worldwide: 30% of reservoir potential would be unavailable because of land occupation by environmental and human development. Results from this study will help decision makers to understand the reliability of infrastructure systems particularly sensitive to future water availability.

Using genomics to characterize evolutionary potential for conservation of wild populations

PubMed Central

Harrisson, Katherine A; Pavlova, Alexandra; Telonis-Scott, Marina; Sunnucks, Paul

2014-01-01

Genomics promises exciting advances towards the important conservation goal of maximizing evolutionary potential, notwithstanding associated challenges. Here, we explore some of the complexity of adaptation genetics and discuss the strengths and limitations of genomics as a tool for characterizing evolutionary potential in the context of conservation management. Many traits are polygenic and can be strongly influenced by minor differences in regulatory networks and by epigenetic variation not visible in DNA sequence. Much of this critical complexity is difficult to detect using methods commonly used to identify adaptive variation, and this needs appropriate consideration when planning genomic screens, and when basing management decisions on genomic data. When the genomic basis of adaptation and future threats are well understood, it may be appropriate to focus management on particular adaptive traits. For more typical conservations scenarios, we argue that screening genome-wide variation should be a sensible approach that may provide a generalized measure of evolutionary potential that accounts for the contributions of small-effect loci and cryptic variation and is robust to uncertainty about future change and required adaptive response(s). The best conservation outcomes should be achieved when genomic estimates of evolutionary potential are used within an adaptive management framework. PMID:25553064

Developing Interdisciplinary Workforce to Meet Future Aerospace Challenges

NASA Technical Reports Server (NTRS)

Misra, Ajay

2017-01-01

The presentation will focus on the importance of interdisciplinary research for addressing future aerospace challenges. Examples of current research activities at NASA's Glenn Research Center will be provided to illustrate the importance of interdisciplinary research. Challenges with conducting interdisciplinary research will be discussed.

Empowering patients through social media: the benefits and challenges.

PubMed

Househ, Mowafa; Borycki, Elizabeth; Kushniruk, Andre

2014-03-01

This article explores the range of social media platforms used by patients and examines the benefits and challenges of using these tools from a patient perspective. A literature review was performed to investigate the use of social media technology by patients. The MEDLINE database was searched using the terms "social media" and "patient." The search was conducted in September 2012 and yielded 765 abstracts. Initially, 63 abstracts were selected. All articles dating from 2004 through 2012 were included. Only 12 articles were found to be relevant for the purposes of the review. The results of this research found that there appears to be an increase in the use of social media by patients across the healthcare spectrum. The research indicates a promising future for the use of social media by patients; however, evidence related to the efficacy and effectiveness of social media is currently limited. Various challenges have also been identified relating to privacy and security concerns, usability, the manipulation of identity, and misinformation. The use of social media technology is an emerging trend for patients who are seeking health information. Conclusions are that such technology holds promise for improving patient engagement and empowerment and community building. Social media has a future in healthcare, especially with regard to patient engagement and empowerment; however, there are several challenges to overcome before the technology can achieve its potential.

Sustainable Development and Energy Geotechnology Potential Roles for Geotechnical Engineering

DOE Office of Scientific and Technical Information (OSTI.GOV)

FragaszyProgram Dire, Dr. R. J.; Santamarina, Carlos; Espinoza, N.

2011-01-01

The world is facing unprecedented challenges related to energy resources, global climate change, material use, and waste generation. Failure to address these challenges will inhibit the growth of the developing world and will negatively impact the standard of living and security of future generations in all nations. The solutions to these challenges will require multidisciplinary research across the social and physical sciences and engineering. Although perhaps not always recognized, geotechnical engineering expertise is critical to the solution of many energy and sustainability-related problems. Hence, geotechnical engineers and academicians have opportunity and responsibility to contribute to the solution of these worldwidemore » problems. Research will need to be extended to non-standard issues such as thermal properties of soils; sediment and rock response to extreme conditions and at very long time scales; coupled hydro-chemo-thermo-bio-mechanical processes; positive feedback systems; the development of discontinuities; biological modification of soil properties; spatial variability; and emergent phenomena. Clearly, the challenges facing geotechnical engineering in the future will require a much broader knowledge base than our traditional educational programs provide. The geotechnical engineering curricula, from undergraduate education through continuing professional education, must address the changing needs of a profession that will increasingly be engaged in alternative/renewable energy production; energy efficiency; sustainable design, enhanced and more efficient use of natural resources, waste management, and underground utilization.« less

Gloom and doom? The future of marine capture fisheries

PubMed Central

Garcia, Serge M.; Grainger, Richard J. R.

2005-01-01

Predicting global fisheries is a high-order challenge but predictions have been made and updates are needed. Past forecasts, present trends and perspectives of key parameters of the fisheries—including potential harvest, state of stocks, supply and demand, trade, fishing technology and governance—are reviewed in detail, as the basis for new forecasts and forecasting performance assessment. The future of marine capture fisheries will be conditioned by the political, social and economic evolution of the world within which they operate. Consequently, recent global scenarios for the future world are reviewed, with the emphasis on fisheries. The main driving forces (e.g. global economic development, demography, environment, public awareness, information technology, energy, ethics) including aquaculture are described. Outlooks are provided for each aspect of the fishery sector. The conclusion puts these elements in perspective and offers the authors’ personal interpretation of the possible future pathway of fisheries, the uncertainty about it and the still unanswered questions of direct relevance in shaping that future. PMID:15713587

Clinical Research with Transcranial Direct Current Stimulation (tDCS): Challenges and Future Directions

PubMed Central

Brunoni, Andre Russowsky; Nitsche, Michael A.; Bolognini, Nadia; Bikson, Marom; Wagner, Tim; Merabet, Lotfi; Edwards, Dylan J.; Valero-Cabre, Antoni; Rotenberg, Alexander; Pascual-Leone, Alvaro; Ferrucci, Roberta; Priori, Alberto; Boggio, Paulo; Fregni, Felipe

2011-01-01

Background Transcranial direct current stimulation (tDCS) is a neuromodulatory technique that delivers low-intensity, direct current to cortical areas facilitating or inhibiting spontaneous neuronal activity. In the past ten years, tDCS physiological mechanisms of action have been intensively investigated giving support for the investigation of its applications in clinical neuropsychiatry and rehabilitation. However, new methodological, ethical, and regulatory issues emerge when translating the findings of preclinical and phase I studies into phase II and III clinical studies. The aim of this comprehensive review is to discuss the key challenges of this process and possible methods to address them. Methods We convened a workgroup of researchers in the field to review, discuss and provide updates and key challenges of neuromodulation use for clinical research. Main Findings/Discussion We reviewed several basic and clinical studies in the field and identified potential limitations, taking into account the particularities of the technique. We review and discuss the findings into four topics: (i) mechanisms of action of tDCS, parameters of use and computer-based human brain modeling investigating electric current fields and magnitude induced by tDCS; (ii) methodological aspects related to the clinical research of tDCS as divided according to study phase (i.e., preclinical, phase I, phase II and phase III studies); (iii) ethical and regulatory concerns; (iv) future directions regarding novel approaches, novel devices, and future studies involving tDCS. Finally, we propose some alternative methods to facilitate clinical research on tDCS. PMID:22037126

A survey on the coordination of connected and automated vehicles at intersections and merging at highway on-ramps

DOE PAGES

Rios-Torres, Jackeline; Malikopoulos, Andreas A.

2016-09-07

Connected and automated vehicles (CAVs) have the potential to improve safety by reducing and mitigating traffic accidents. They can also provide opportunities to reduce transportation energy consumption and emissions by improving traffic flow. Vehicle communication with traffic structures and traffic lights can allow individual vehicles to optimize their operation and account for unpredictable changes. This paper summarizes the developments and the research trends in coordination with the CAVs that have been reported in the literature to date. In conclusion, remaining challenges and potential future research directions are also discussed.

Shape memory alloys: Properties and biomedical applications

NASA Astrophysics Data System (ADS)

Mantovani, Diego

2000-10-01

Shape memory alloys provide new insights for the design of biomaterials in bioengineering for the design of artificial organs and advanced surgical instruments, since they have specific characteristics and unusual properties. This article will examine (a) the four properties of shape memory alloys, (b) medical applications with high potential for improving the present and future quality of life, and (c) concerns regarding the biocom-patibility properties of nickel-titanium alloys. In particular, the long-term challenges of using shape memory alloys will be discussed, regarding corrosion and potential leakage of elements and ions that could be toxic to cells, tissues and organs.

Ostracod (Ostracoda, Crustacea) genomics - Promises and challenges.

PubMed

Schön, Isa; Martens, Koen

2016-10-01

Ostracods are well-suited model organisms for evolutionary research. Classic genetic techniques have mostly been used for phylogenetic studies on Ostracoda and were somewhat affected by the lack of large numbers of suitable markers. Genomic methods with their huge potential have so far rarely been applied to this group of crustaceans. We provide relevant examples of genomic studies on other organisms to propose future avenues of genomic ostracod research. At the same time, we suggest solutions to the potential problems in ostracods that the application of genomic techniques might present. Copyright © 2016 Elsevier B.V. All rights reserved.

Deep tissue single cell MSC ablation using a fiber laser source to evaluate therapeutic potential in osteogenesis imperfecta

NASA Astrophysics Data System (ADS)

Tehrani, Kayvan F.; Pendleton, Emily G.; Lin, Charles P.; Mortensen, Luke J.

2016-04-01

Osteogenesis imperfecta (OI) is a currently uncurable disease where a mutation in collagen type I yields brittle bones. One potential therapy is transplantation of mesenchymal stem cells (MSCs), but controlling and enhancing transplanted cell survival has proven challenging. Therefore, we use a 2- photon imaging system to study individual transplanted cells in the living bone marrow. We ablated cells deep in the bone marrow and observed minimal collateral damage to surrounding tissue. Future work will evaluate the local impact of transplanted MSCs on bone deposition in vivo.

Conducting Polymers and Their Applications in Diabetes Management.

PubMed

Zhao, Yu; Cao, Luyao; Li, Lanlan; Cheng, Wen; Xu, Liangliang; Ping, Xinyu; Pan, Lijia; Shi, Yi

2016-10-26

Advances in conducting polymers (CPs) have promoted the development of diabetic monitoring and treatment, which is of great significance in human healthcare and modern medicine. CPs are special polymers with physical and electrochemical features resembling metals, inorganic semiconductors and non-conducting polymers. To improve and extend their properties, the fabrication of CPs and CP composites has attracted intensive attention in recent decades. Some CPs are biocompatible and suitable for biomedical use. Thus, the intriguing properties of CPs make wearable, noninvasive, continuous diabetes managing devices and other potential applications in diabetes possible in the near future. To highlight the recent advances of CPs and their derived materials (especially in conducting polymer hydrogels), here we discuss their fabrication and characterization, review the current state-of-the-art research in diabetes management based on these materials and describe current challenges as well as future potential research directions.

Perfusion mammalian cell culture for recombinant protein manufacturing - A critical review.

PubMed

Bielser, Jean-Marc; Wolf, Moritz; Souquet, Jonathan; Broly, Hervé; Morbidelli, Massimo

The manufacturing of recombinant protein is traditionally divided in two main steps: upstream (cell culture and synthesis of the target protein) and downstream (purification and formulation of the protein into a drug substance or drug product). Today, cost pressure, market uncertainty and market growth, challenge the existing manufacturing technologies. Leaders in the field are active in designing the process of the future and continuous manufacturing is recurrently mentioned as a potential solution to address some of the current limitations. This review focuses on the application of continuous processing to the first step of the manufacturing process. Enabling technologies and operation modes are described in the first part. In the second part, recent advances in the field that have the potential to support its successful future development are critically discussed. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Conducting Polymers and Their Applications in Diabetes Management

PubMed Central

Zhao, Yu; Cao, Luyao; Li, Lanlan; Cheng, Wen; Xu, Liangliang; Ping, Xinyu; Pan, Lijia; Shi, Yi

2016-01-01

Advances in conducting polymers (CPs) have promoted the development of diabetic monitoring and treatment, which is of great significance in human healthcare and modern medicine. CPs are special polymers with physical and electrochemical features resembling metals, inorganic semiconductors and non-conducting polymers. To improve and extend their properties, the fabrication of CPs and CP composites has attracted intensive attention in recent decades. Some CPs are biocompatible and suitable for biomedical use. Thus, the intriguing properties of CPs make wearable, noninvasive, continuous diabetes managing devices and other potential applications in diabetes possible in the near future. To highlight the recent advances of CPs and their derived materials (especially in conducting polymer hydrogels), here we discuss their fabrication and characterization, review the current state-of-the-art research in diabetes management based on these materials and describe current challenges as well as future potential research directions. PMID:27792179

Data Farming and the Exploration of Inter-Agency, Inter-Disciplinary, and International "What If?" Questions

NASA Technical Reports Server (NTRS)

Anderson, Steve; Horne, Gary; Meyer, Ted; Triola, Larry

2012-01-01

Data farming uses simulation modeling, high performance computing, and analysis to examine questions of interest with large possibility spaces.This methodology allows for the examination of whole landscapes of potential outcomes and provides the capability of executing enough experiments so that outlets might be captured and examined for insights. This capability may be quite informative when used to examine the plethora of "What if?" questions that result when examining potential scenarios that our forces may face in the uncertain world of the future. Many of theses scenarios most certainly will be challenging and solutions may depend on interagency and international collaboration as well as the need for inter-disciplinary scientific inquiry preceding these events. In this paper, we describe data farming and illustrate it in the context of application to questions inherent to military decision-making as we consider alternate future scenarios.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loftin, B.; Abramczyk, G.

Destructive testing of an ES-3100 Shipping Container was completed by the Packaging Technology and Pressurized Systems organization within the Savannah River National Laboratory in order to qualify the ES-3100 as a candidate storage and transport package for applications at various facilities at the Savannah River Site. The testing consisted of the detonation of three explosive charges at separate locations on a single ES-3100. The locations for the placement were chosen based the design of the ES-3100 as well as the most likely places for the package to incur damage as a result of the detonation. The testing was completed atmore » an offsite location, which raised challenges as well as allowed for development of new partnerships for this testing and for potential future testing. The results of the testing, the methods used to complete the testing, and similar, potential future work will be discussed.« less

The future of forensic DNA analysis

PubMed Central

Butler, John M.

2015-01-01

The author's thoughts and opinions on where the field of forensic DNA testing is headed for the next decade are provided in the context of where the field has come over the past 30 years. Similar to the Olympic motto of ‘faster, higher, stronger’, forensic DNA protocols can be expected to become more rapid and sensitive and provide stronger investigative potential. New short tandem repeat (STR) loci have expanded the core set of genetic markers used for human identification in Europe and the USA. Rapid DNA testing is on the verge of enabling new applications. Next-generation sequencing has the potential to provide greater depth of coverage for information on STR alleles. Familial DNA searching has expanded capabilities of DNA databases in parts of the world where it is allowed. Challenges and opportunities that will impact the future of forensic DNA are explored including the need for education and training to improve interpretation of complex DNA profiles. PMID:26101278

Expression library immunization can confer protection against lethal challenge with African swine fever virus.

PubMed

Lacasta, Anna; Ballester, María; Monteagudo, Paula L; Rodríguez, Javier M; Salas, María L; Accensi, Francesc; Pina-Pedrero, Sonia; Bensaid, Albert; Argilaguet, Jordi; López-Soria, Sergio; Hutet, Evelyne; Le Potier, Marie Frédérique; Rodríguez, Fernando

2014-11-01

African swine fever is one of the most devastating pig diseases, against which there is no vaccine available. Recent work from our laboratory has demonstrated the protective potential of DNA vaccines encoding three African swine fever viral antigens (p54, p30, and the hemagglutinin extracellular domain) fused to ubiquitin. Partial protection was afforded in the absence of detectable antibodies prior to virus challenge, and survival correlated with the presence of a large number of hemagglutinin-specific CD8(+) T cells in blood. Aiming to demonstrate the presence of additional CD8(+) T-cell determinants with protective potential, an expression library containing more than 4,000 individual plasmid clones was constructed, each one randomly containing a Sau3AI restriction fragment of the viral genome (p54, p30, and hemagglutinin open reading frames [ORFs] excluded) fused to ubiquitin. Immunization of farm pigs with the expression library yielded 60% protection against lethal challenge with the virulent E75 strain. These results were further confirmed by using specific-pathogen-free pigs after challenging them with 10(4) hemadsorbing units (HAU) of the cell culture-adapted strain E75CV1. On this occasion, 50% of the vaccinated pigs survived the lethal challenge, and 2 out of the 8 immunized pigs showed no viremia or viral excretion at any time postinfection. In all cases, protection was afforded in the absence of detectable specific antibodies prior to challenge and correlated with the detection of specific T-cell responses at the time of sacrifice. In summary, our results clearly demonstrate the presence of additional protective determinants within the African swine fever virus (ASFV) genome and open up the possibility for their future identification. African swine fever is a highly contagious disease of domestic and wild pigs that is endemic in many sub-Saharan countries, where it causes important economic losses and is currently in continuous expansion across Europe. Unfortunately, there is no treatment nor an available vaccine. Early attempts using attenuated vaccines demonstrated their potential to protect pigs against experimental infection. However, their use in the field remains controversial due to safety issues. Although inactive and subunit vaccines did not confer solid protection against experimental ASFV infection, our DNA vaccination results have generated new expectations, confirming the key role of T-cell responses in protection and the existence of multiple ASFV antigens with protective potential, more of which are currently being identified. Thus, the future might bring complex and safe formulations containing more than a single viral determinant to obtain broadly protective vaccines. We believe that obtaining the optimal vaccine formulation it is just a matter of time, investment, and willingness. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Phoretic Self-Propulsion

NASA Astrophysics Data System (ADS)

Moran, Jeffrey L.; Posner, Jonathan D.

2017-01-01

It is well-known that micro- and nanoparticles can move by phoretic effects in response to externally imposed gradients of scalar quantities such as chemical concentration or electric potential. A class of active colloids can propel themselves through aqueous media by generating local gradients of concentration and electrical potential via surface reactions. Phoretic active colloids can be controlled using external stimuli and can mimic collective behaviors exhibited by many biological swimmers. Low-Reynolds number physicochemical hydrodynamics imposes unique challenges and constraints that must be understood for the practical potential of active colloids to be realized. Here, we review the rich physics underlying the operation of phoretic active colloids, describe their interactions and collective behaviors, and discuss promising directions for future research.

Visualizing Alternative Phosphorus Scenarios for Future Food Security

PubMed Central

Neset, Tina-Simone; Cordell, Dana; Mohr, Steve; VanRiper, Froggi; White, Stuart

2016-01-01

The impact of global phosphorus scarcity on food security has increasingly been the focus of scientific studies over the past decade. However, systematic analyses of alternative futures for phosphorus supply and demand throughout the food system are still rare and provide limited inclusion of key stakeholders. Addressing global phosphorus scarcity requires an integrated approach exploring potential demand reduction as well as recycling opportunities. This implies recovering phosphorus from multiple sources, such as food waste, manure, and excreta, as well as exploring novel opportunities to reduce the long-term demand for phosphorus in food production such as changing diets. Presently, there is a lack of stakeholder and scientific consensus around priority measures. To therefore enable exploration of multiple pathways and facilitate a stakeholder dialog on the technical, behavioral, and institutional changes required to meet long-term future phosphorus demand, this paper introduces an interactive web-based tool, designed for visualizing global phosphorus scenarios in real time. The interactive global phosphorus scenario tool builds on several demand and supply side measures that can be selected and manipulated interactively by the user. It provides a platform to facilitate stakeholder dialog to plan for a soft landing and identify a suite of concrete priority options, such as investing in agricultural phosphorus use efficiency, or renewable fertilizers derived from phosphorus recovered from wastewater and food waste, to determine how phosphorus demand to meet future food security could be attained on a global scale in 2040 and 2070. This paper presents four example scenarios, including (1) the potential of full recovery of human excreta, (2) the challenge of a potential increase in non-food phosphorus demand, (3) the potential of decreased animal product consumption, and (4) the potential decrease in phosphorus demand from increased efficiency and yield gains in crop and livestock systems. PMID:27840814

Visualizing Alternative Phosphorus Scenarios for Future Food Security.

PubMed

Neset, Tina-Simone; Cordell, Dana; Mohr, Steve; VanRiper, Froggi; White, Stuart

2016-01-01

The impact of global phosphorus scarcity on food security has increasingly been the focus of scientific studies over the past decade. However, systematic analyses of alternative futures for phosphorus supply and demand throughout the food system are still rare and provide limited inclusion of key stakeholders. Addressing global phosphorus scarcity requires an integrated approach exploring potential demand reduction as well as recycling opportunities. This implies recovering phosphorus from multiple sources, such as food waste, manure, and excreta, as well as exploring novel opportunities to reduce the long-term demand for phosphorus in food production such as changing diets. Presently, there is a lack of stakeholder and scientific consensus around priority measures. To therefore enable exploration of multiple pathways and facilitate a stakeholder dialog on the technical, behavioral, and institutional changes required to meet long-term future phosphorus demand, this paper introduces an interactive web-based tool, designed for visualizing global phosphorus scenarios in real time. The interactive global phosphorus scenario tool builds on several demand and supply side measures that can be selected and manipulated interactively by the user. It provides a platform to facilitate stakeholder dialog to plan for a soft landing and identify a suite of concrete priority options, such as investing in agricultural phosphorus use efficiency, or renewable fertilizers derived from phosphorus recovered from wastewater and food waste, to determine how phosphorus demand to meet future food security could be attained on a global scale in 2040 and 2070. This paper presents four example scenarios, including (1) the potential of full recovery of human excreta, (2) the challenge of a potential increase in non-food phosphorus demand, (3) the potential of decreased animal product consumption, and (4) the potential decrease in phosphorus demand from increased efficiency and yield gains in crop and livestock systems.

Implications of climate change predictions for UK cropping and prospects for possible mitigation: a review of challenges and potential responses.

PubMed

Rial-Lovera, Karen; Davies, W Paul; Cannon, Nicola D

2017-01-01

The UK, like the rest of the world, is confronting the impacts of climate change. Further changes are expected and they will have a profound effect on agriculture. Future crop production will take place against increasing CO 2 levels and temperatures, decreasing water availability, and increasing frequency of extreme weather events. This review contributes to research on agricultural practices for climate change, but with a more regional perspective. The present study explores climate change impacts on UK agriculture, particularly food crop production, and how to mitigate and build resilience to climate change by adopting and/or changing soil management practices, including fertilisation and tillage systems, new crop adoption and variety choice. Some mitigation can be adopted in the shorter term, such as changes in crop type and reduction in fertiliser use, but in other cases the options will need greater investment and longer adaptation period. This is the case for new crop variety development and deployment, and possible changes to soil cultivations. Uncertainty of future weather conditions, particularly extreme weather, also affect decision-making for adoption of practices by farmers to ensure more stable and sustainable production. Even when there is real potential for climate change mitigation, it can sometimes be more difficult to accomplish with certainty on-farm. Better future climate projections and long-term investments will be required to create more resilient agricultural systems in the UK in the face of climate change challenges. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

NASA Mars 2020 Rover Mission: New Frontiers in Science

NASA Technical Reports Server (NTRS)

Calle, Carlos I.

2014-01-01

The Mars 2020 rover mission is the next step in NASAs robotic exploration of the red planet. The rover, based on the Mars Science Laboratory Curiosity rover now on Mars, will address key questions about the potential for life on Mars. The mission would also provide opportunities to gather knowledge and demonstrate technologies that address the challenges of future human expeditions to Mars.Like the Mars Science Laboratory rover, which has been exploring Mars since 2012, the Mars 2020 spacecraft will use a guided entry, descent, and landing system which includes a parachute, descent vehicle, and, during the provides the ability to land a very large, heavy rover on the surface of Mars in a more precise landing area. The Mars 2020 mission is designed to accomplish several high-priority planetary science goals and will be an important step toward meeting NASAs challenge to send humans to Mars in the 2030s. The mission will conduct geological assessments of the rover's landing site, determine the habitability of the environment, search for signs of ancient Martian life, and assess natural resources and hazards for future human explorers. The science instruments aboard the rover also will enable scientists to identify and select a collection of rock and soil samples that will be stored for potential return to Earth in the future. The rover also may help designers of a human expedition understand the hazards posed by Martian dust and demonstrate how to collect carbon dioxide from the atmosphere, which could be a valuable resource for producing oxygen and rocket fuel.

Global Antimicrobial Stewardship: A Closer Look at the Formidable Implementation Challenges

PubMed Central

Tiong, John J. L.; Loo, Jason S. E.; Mai, Chun-Wai

2016-01-01

Antimicrobial stewardship (AMS) has been touted as one of the key strategies required in tackling worldwide escalation of antibiotic resistance. Although AMS has optimized antibiotic usage and reduced the incidence of resistance development in some regions, its full global potential has been curtailed by various AMS-impeding factors. This article seeks to highlight in a detailed perspective, the key challenges that hamper global AMS endeavors, some of which include the paucity of effective implementation strategies that cater for the challenging settings of developing nations, the slow response of governments, uncoordinated AMS activities as well as implementation fragmentation across different sectors and countries. The authors of this article call upon all stakeholders to pay attention to these seemingly obvious but often under-addressed problems. If left unresolved, this may render all current and future AMS initiatives pointless. PMID:27899924

Science-society collaboration for robust adaptation planning in water management - The Maipo River Basin in Chile

NASA Astrophysics Data System (ADS)

Ocampo Melgar, Anahí; Vicuña, Sebastián; Gironás, Jorge

2015-04-01

The Metropolitan Region (M.R.) in Chile is populated by over 6 million people and supplied by the Maipo River and its large number of irrigation channels. Potential environmental alterations caused by global change will extremely affect managers and users of water resources in this semi-arid basin. These hydro-climatological impacts combined with demographic and economic changes will be particularly complex in the city of Santiago, due to the diverse, counterpoised and equally important existing activities and demands. These challenges and complexities request the implementation of flexible plans and actions to adapt policies, institutions, infrastructure and behaviors to a new future with climate change. Due to the inherent uncertainties in the future, a recent research project entitled MAPA (Maipo Adaptation Plan for its initials in Spanish) has formed a collaborative science-society platform to generate insights into the vulnerabilities, challenges and possible mitigation measures that would be necessary to deal with the potential changes in the M.R. This large stakeholder platform conformed by around 30 public, private and civil society organizations, both at the local and regional level and guided by a Robust Decision Making Framework (RDMF) has identified vulnerabilities, future scenarios, performance indicators and mitigation measures for the Maipo River basin. The RDMF used in this project is the XLRM framework (Lempert et al. 2006) that incorporates policy levers (L), exogenous uncertainties (X), measures of performance standards (M) and relationships (R) in an interlinked process. Both stakeholders' expertise and computational capabilities have been used to create hydrological models for the urban, rural and highland sectors supported also by the Water Evaluation and Planning system software (WEAP). The identification of uncertainties and land use transition trends was used to develop future development scenarios to explore possible water management challenges. Finally a collaborative process guided by the Water Security concept resulted in the identification of local-based performance indicators that will be used to evaluate scenarios and the need for adaptation measures. This collaborative approach has allowed capturing the general aspirations of different water users in this basin and identifying the main challenges and possible adaptation measures that will be necessary to explore if some of these scenarios become real. Furthermore, this science-society effort has formed the basis for a more extended and long-term collaboration for the implementation of adaptation measures to other unavoidable land-based changes in the Maipo river basin.

Challenges in predicting climate and environmental effects on vector-borne disease episystems in a changing world.

PubMed

Tabachnick, W J

2010-03-15

Vector-borne pathogens cause enormous suffering to humans and animals. Many are expanding their range into new areas. Dengue, West Nile and Chikungunya have recently caused substantial human epidemics. Arthropod-borne animal diseases like Bluetongue, Rift Valley fever and African horse sickness pose substantial threats to livestock economies around the world. Climate change can impact the vector-borne disease epidemiology. Changes in climate will influence arthropod vectors, their life cycles and life histories, resulting in changes in both vector and pathogen distribution and changes in the ability of arthropods to transmit pathogens. Climate can affect the way pathogens interact with both the arthropod vector and the human or animal host. Predicting and mitigating the effects of future changes in the environment like climate change on the complex arthropod-pathogen-host epidemiological cycle requires understanding of a variety of complex mechanisms from the molecular to the population level. Although there has been substantial progress on many fronts the challenges to effectively understand and mitigate the impact of potential changes in the environment on vector-borne pathogens are formidable and at an early stage of development. The challenges will be explored using several arthropod-borne pathogen systems as illustration, and potential avenues to meet the challenges will be presented.

Preface

NASA Technical Reports Server (NTRS)

Rosenzweig, Cynthia (Editor); Hillel, Daniel (Editor)

2015-01-01

The potential effects of climate change on the food production system are raising concern both globally and regionally. The system is already challenged to deliver sufficient and healthy sustenance to all people, and is certain to be even further challenged as world population grows and price shocks loom. The prospect of climate change intensifies these challenges, raising the risk that more frequent and intense extreme weather events threaten the stability of agricultural production in regions around the globe. This two-part set is an important contribution to the ongoing Imperial College Press (ICP) Series on Climate Change Impacts, Adaptation, and Mitigation. This series aims to provide the know ledge base necessary for understanding and responding to climate change, in both its current form and future manifestations. In these volumes, ·leading agricultural researchers have come together to contribute their expertise on actual and potential climate change impacts, adaptation strategies, and mitigation efforts. This ongoing series is jointly published by The American Society of Agronomy (ASA), Crop Science Society of America (CSSA), and Soil Science Society of America (SSSA), together with ICP. We hope that this fruitful cooperation will continue for many years to come, as it spurs the global effort to define and meet the great food security and climate change challenges of our time.

The Use of Statistical Downscaling to Project Regional Climate Changes as they Relate to Future Energy Production

NASA Astrophysics Data System (ADS)

Werth, D. W.; O'Steen, L.; Chen, K.; Altinakar, M. S.; Garrett, A.; Aleman, S.; Ramalingam, V.

2010-12-01

Global climate change has the potential for profound impacts on society, and poses significant challenges to government and industry in the areas of energy security and sustainability. Given that the ability to exploit energy resources often depends on the climate, the possibility of climate change means we cannot simply assume that the untapped potential of today will still exist in the future. Predictions of future climate are generally based on global climate models (GCMs) which, due to computational limitations, are run at spatial resolutions of hundreds of kilometers. While the results from these models can predict climatic trends averaged over large spatial and temporal scales, their ability to describe the effects of atmospheric phenomena that affect weather on regional to local scales is inadequate. We propose the use of several optimized statistical downscaling techniques that can infer climate change at the local scale from coarse resolution GCM predictions, and apply the results to assess future sustainability for two sources of energy production dependent on adequate water resources: nuclear power (through the dissipation of waste heat from cooling towers, ponds, etc.) and hydroelectric power. All methods will be trained with 20th century data, and applied to data from the years 2040-2049 to get the local-scale changes. Models of cooling tower operation and hydropower potential will then use the downscaled data to predict the possible changes in energy production, and the implications of climate change on plant siting, design, and contribution to the future energy grid can then be examined.

Modelling regional cropping patterns under scenarios of climate and socio-economic change in Hungary.

PubMed

Li, Sen; Juhász-Horváth, Linda; Pintér, László; Rounsevell, Mark D A; Harrison, Paula A

2018-05-01

Impacts of socio-economic, political and climatic change on agricultural land systems are inherently uncertain. The role of regional and local-level actors is critical in developing effective policy responses that accommodate such uncertainty in a flexible and informed way across governance levels. This study identified potential regional challenges in arable land use systems, which may arise from climate and socio-economic change for two counties in western Hungary: Veszprém and Tolna. An empirically-grounded, agent-based model was developed from an extensive farmer household survey about local land use practices. The model was used to project future patterns of arable land use under four localised, stakeholder-driven scenarios of plausible future socio-economic and climate change. The results show strong differences in farmers' behaviour and current agricultural land use patterns between the two regions, highlighting the need to implement focused policy at the regional level. For instance, policy that encourages local food security may need to support improvements in the capacity of farmers to adapt to physical constraints in Veszprém and farmer access to social capital and environmental awareness in Tolna. It is further suggested that the two regions will experience different challenges to adaptation under possible future conditions (up to 2100). For example, Veszprém was projected to have increased fallow land under a scenario with high inequality, ineffective institutions and higher-end climate change, implying risks of land abandonment. By contrast, Tolna was projected to have a considerable decline in major cereals under a scenario assuming a de-globalising future with moderate climate change, inferring challenges to local food self-sufficiency. The study provides insight into how socio-economic and physical factors influence the selection of crop rotation plans by farmers in western Hungary and how farmer behaviour may affect future risks to agricultural land systems under environmental change. Copyright © 2017 Elsevier B.V. All rights reserved.

The Challenging Experience Questionnaire: Characterization of challenging experiences with psilocybin mushrooms

PubMed Central

Barrett, Frederick S.; Bradstreet, Matthew P.; Leoutsakos, Jeannie-Marie S.; Johnson, Matthew W.; Griffiths, Roland R.

2017-01-01

Acute adverse psychological reactions to classic hallucinogens (“bad trips”, or “challenging experiences”), while usually benign with proper screening, preparation, and support in controlled settings, remain a safety concern in uncontrolled settings (such as illicit use contexts). Anecdotal and case reports suggest potential adverse acute symptoms including affective (panic, depressed mood), cognitive (confusion, feelings of losing sanity), and somatic (nausea, heart palpitation) symptoms. Responses to items from several hallucinogen-sensitive questionnaires (Hallucinogen Rating Scale, the States of Consciousness Questionnaire, and the 5-Dimensional Altered States of Consciousness questionnaire) in an internet survey of challenging experiences with the classic hallucinogen psilocybin were used to construct and validate a Challenging Experience Questionnaire (CEQ). The stand-alone CEQ was then validated in a separate sample. Seven CEQ factors (grief, fear, death, insanity, isolation, physical distress, and paranoia) provide a phenomenological profile of challenging aspects of experiences with psilocybin. Factor scores were associated with the difficulty, meaningfulness, spiritual significance, and change in well-being attributed to the challenging experiences. The factor structure did not differ based on gender or prior struggle with anxiety or depression. The CEQ provides a basis for future investigation of predictors and outcomes of challenging experiences with psilocybin, and should be explored as a measure of challenging experiences with the broad class of classic hallucinogens. PMID:27856683

Challenges and lessons learned in the application of autonomy to space operations

NASA Technical Reports Server (NTRS)

Forrest, David J.; Statman, Joseph I.

2001-01-01

NASA's Space Operations Management Office (SOMO) is working toward a goal of providing an integrated infrastructure of mission and data services for space missions undertaken by NASA enterprises. A significant portion of this effort is focused on reducing the cost of these services. We are interested in the potential of autonomy to reduce operations costs. Some attempts have already been made to apply autonomy and automation in these areas in the past with varying degrees of success. We present brief case histories and the lessons inferred from them. Combining this past experience with anticipated future needs, we attempt to clarify the challenges that must be met in order to realize the benefits of autonomy.

Space and the Third Offset Symposium - Summary Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bahney, B.

The Third Offset Workshop explored the nature of the challenges and opportunities facing the United States as it is increasingly forced to integrate space into defense strategy as well as deterrence and strategic stability frameworks. Participants broadly agreed that Washington’s deep ties to allies and partners, as well as its history of leveraging an innovative U.S private sector, will be enduring competitive advantages against potential rivals into the foreseeable future. Yet panelists also highlighted key challenges from Russia and China’s rapid integration of space capabilities into conventional and nuclear warfighting, the pronounced growth in Chinese and Russian counterspace capabilities, andmore » tensions in the U.S.-Russia relationship.« less

Ensuring pain relief for children at the end of life

PubMed Central

Grégoire, Marie-Claude; Frager, Gerri

2006-01-01

Pain management in the context of pediatric palliative care can be challenging. The present article reviews, through a case-based presentation, the nonpharmacological and pharmacological methods used to ensure adequate pain control in children facing end of life. Details on the impressive range of opioid dosages required and routes of administration are highlighted from published literature and clinical experience. Where available, evidence-based recommendations are provided. Potential side effects of pain medication and barriers to good pain control are discussed. Novel analgesics and innovative delivery methods are presented as future tools enhancing pain relief at the end of life. Some challenges to ethically grounded research in this important context of care are reviewed. PMID:16960633

Challenges of In Space Robotic Servicing

NASA Technical Reports Server (NTRS)

Roberts, Brian John

2015-01-01

As future space missions extend beyond the friendly confines of low earth orbit, robots are becoming an increasingly vital component on flight manifests. While the main focus to-date has been on satellite servicing due to its high commercial potential, robots are also being considered for orbital debris removal, space construction, and asteroid sample retrieval. The robotic technologies and automation required to carry out these missions represent a significant advancement beyond the manipulation technology used previously on the Space Shuttle, the International Space Station, and planetary rovers. While higher demands are being driven by the more ambitious nature of the tasks, the handling of uncooperative targets such as satellites and asteroids, present a greater challenge.

Recent Advances and Future Challenges in Modified Mycotoxin Analysis: Why HRMS Has Become a Key Instrument in Food Contaminant Research

PubMed Central

Righetti, Laura; Paglia, Giuseppe; Galaverna, Gianni; Dall’Asta, Chiara

2016-01-01

Mycotoxins are secondary metabolites produced by pathogenic fungi in crops worldwide. These compounds can undergo modification in plants, leading to the formation of a large number of possible modified forms, whose toxicological relevance and occurrence in food and feed is still largely unexplored. The analysis of modified mycotoxins by liquid chromatography–mass spectrometry remains a challenge because of their chemical diversity, the large number of isomeric forms, and the lack of analytical standards. Here, the potential benefits of high-resolution and ion mobility mass spectrometry as a tool for separation and structure confirmation of modified mycotoxins have been investigated/reviewed. PMID:27918432

Challenges in Bio-fabrication of Organoid Cultures.

PubMed

Peng, Weijie; Datta, Pallab; Wu, Yang; Dey, Madhuri; Ayan, Bugra; Dababneh, Amer; Ozbolat, Ibrahim T

2018-06-01

Three-dimensional (3D) organoids have shown advantages in cell culture over traditional two-dimensional (2D) culture, and have great potential in various applications of tissue engineering. However, there are limitations in current organoid fabrication technologies, such as uncontrolled size, poor reproductively, and inadequate complexity of organoids. In this chapter, we present the existing techniques and discuss the major challenges for 3D organoid biofabrication. Future perspectives on organoid bioprinting are also discussed, where bioprinting technologies are expected to make a major contribution in organoid fabrication, such as realizing mass production and constructing complex heterotypic tissues, and thus further advance the translational application of organoids in tissue engineering and regenerative medicine as well drug testing and pharmaceutics.

NASA Fixed Wing Project: Green Technologies for Future Aircraft Generation

NASA Technical Reports Server (NTRS)

DelRosario, Ruben

2014-01-01

The NASA Fundamental Aeronautics Fixed Wing (FW) Project addresses the comprehensive challenge of enabling revolutionary energy efficiency improvements in subsonic transport aircraft combined with dramatic reductions in harmful emissions and perceived noise to facilitate sustained growth of the air transportation system. Advances in multidisciplinary technologies and the development of unconventional aircraft systems offer the potential to achieve these improvements. The presentation will highlight the FW Project vision of revolutionary systems and technologies needed to achieve the challenging goals of aviation. Specifically, the primary focus of the FW Project is on the N+3 generation that is, vehicles that are three generations beyond the current state of the art, requiring mature technology solutions in the 2025-30 timeframe.

Challenging Futures Studies To Enhance Participatory River Basin Management

NASA Astrophysics Data System (ADS)

van der Helm, R.

Can the field of futures research help advance participatory management of river basins? This question is supposed to be answered by the present study of which this paper will mainly address the theoretical and conceptual point of view. The 2000 EU Framework directive on water emphasises at least two aspects that will mark the future management of river basins: the need for long-term planning, and a demand for participation. Neither the former nor the latter are new concepts as such, but its combination is in some sense revolutionary. Can long-term plans be made (and implemented) in a participative way, what tools could be useful in this respect, and does this lead to a satisfactory situation in terms of both reaching physical targets and enhancing social-institutional manageability? A possibly rich way to enter the discussion is to challenge futures research as a concept and a practice for enabling multiple stakeholders to design appropriate policies. Futures research is the overall field in which several methods and techniques (like scenario analysis) are mobilised to systematically think through and/or design the future. As such they have proven to be rich exercises to trigger ideas, stimulate debate and design desirable futures (and how to get there). More importantly these exercises have the capability to reconstitute actor relations, and by nature go beyond the institutional boundaries. Arguably the relation between futures research and the planning process is rather distant. Understandably commitments on the direct implementation of the results are hardly ever made, but its impact on changes in the capabilities of the network of actors involved may be large. As a hypothesis we consider that the distant link between an image of the future and the implementation in policy creates sufficient distance for actors to participate (in terms of responsibilities, legal constraints, etc.) and generate potentials, and enough degrees of freedom needed for a successful implementation. However, critical conceptual and design requirements have to be met in order to realise futures research potentials. Since the beginning of the 1990s futures studies are becoming (again) more and more widespread in many different domains (technology, education, urban development, agriculture, environment, etc.). Recently, experiences have been launched and are currently being launched in the water sector (of which the World Water Vision is a well -known - but not necessarily the most representative - example). Although futures studies on a river basin level are still scarce, they will offer already sufficient material for empirical analysis. The research, effectuated within a larger framework study on the implications of futures studies for environmental research, offers at this stage initially a conceptual understanding.

Uncertainties in the projection of species distributions related to general circulation models

PubMed Central

Goberville, Eric; Beaugrand, Grégory; Hautekèete, Nina-Coralie; Piquot, Yves; Luczak, Christophe

2015-01-01

Ecological Niche Models (ENMs) are increasingly used by ecologists to project species potential future distribution. However, the application of such models may be challenging, and some caveats have already been identified. While studies have generally shown that projections may be sensitive to the ENM applied or the emission scenario, to name just a few, the sensitivity of ENM-based scenarios to General Circulation Models (GCMs) has been often underappreciated. Here, using a multi-GCM and multi-emission scenario approach, we evaluated the variability in projected distributions under future climate conditions. We modeled the ecological realized niche (sensu Hutchinson) and predicted the baseline distribution of species with contrasting spatial patterns and representative of two major functional groups of European trees: the dwarf birch and the sweet chestnut. Their future distributions were then projected onto future climatic conditions derived from seven GCMs and four emissions scenarios using the new Representative Concentration Pathways (RCPs) developed for the Intergovernmental Panel on Climate Change (IPCC) AR5 report. Uncertainties arising from GCMs and those resulting from emissions scenarios were quantified and compared. Our study reveals that scenarios of future species distribution exhibit broad differences, depending not only on emissions scenarios but also on GCMs. We found that the between-GCM variability was greater than the between-RCP variability for the next decades and both types of variability reached a similar level at the end of this century. Our result highlights that a combined multi-GCM and multi-RCP approach is needed to better consider potential trajectories and uncertainties in future species distributions. In all cases, between-GCM variability increases with the level of warming, and if nothing is done to alleviate global warming, future species spatial distribution may become more and more difficult to anticipate. When future species spatial distributions are examined, we propose to use a large number of GCMs and RCPs to better anticipate potential trajectories and quantify uncertainties. PMID:25798227

Joint Operating Environment: Trends and Challenges for the Future Joint Force Through 2030

DTIC Science & Technology

2007-12-01

unmanned underwater vehicles loom on the horizon that can be swarmed against our ports and cities. Self - healing , networked minefields will... robots in an effort to provide the basic physical labor needed by the society. Russia has seen a major withdrawal of it population from the Far...of criminal elements. International organized crime, motivated by greed and self -interest, may increase as potential security threats to the

Research perspectives in first metatarsal osteotomy and fixation stability.

PubMed

Landsman, A S; Higgins, K R; Lampe, N

1996-07-01

Well-designated research is required to provide clinical guidance by validation of old and new methods. Variables, including technologic advancement in surgical techniques, diagnosis, shoe design, and immobilization all contribute to the challenge of investigating surgical procedures of the foot. This article highlights some of the relevant research pertaining to first metatarsal osteotomies and internal fixation and provides direction for potential, future research. Numerous aspects about the research techniques involved are discussed.

Vaccines for Drug Abuse

PubMed Central

Shen, Xiaoyun; Orson, Frank M.; Kosten, Thomas R.

2012-01-01

Current medications for drug abuse have had only limited success. Anti-addiction vaccines to elicit antibodies that block the pharmacological effects of drugs have great potential for treating drug abuse. We review the status for two vaccines that are undergoing clinical trials (cocaine and nicotine) and two that are still in pre-clinical development (methamphetamine and heroin). We also outline the challenges and ethical concerns for anti-addiction vaccine development and their use as future therapeutics. PMID:22130115

The Third Nuclear Age: How I Learned to Start Worrying about the Clean Bomb

DTIC Science & Technology

2013-02-14

Fourth generation fusion nuclear weapons (FGNW) represent a significant improvement in nuclear weapons technology and suggest the potential for...future challenges that the United States and its Air Force may face twenty-five years from now. This paper does not answer whether the fusion technology...is possible and assumes it as an inevitable technological advancement. Instead, this study predicts a world in which low yield, clean fusion

The Use of EEG as a Workload Assessment Tool in Flight Test

DTIC Science & Technology

1993-10-01

resource, single pool, mental model (Wickens) 9 which postulates that the human has a limited source of mental potential and when tasked with multiple...psychological spectrum presents an interesting challenge for future research. 10 EP Amplitude Microvolts) I-J ---- Single Task ......... Difficult...example, they obtained a p value of .000025 for a single test and then applied a Bonferroni correction to yield a conservatively corrected value of p

Terahertz: the Far-Ir Challenge

NASA Astrophysics Data System (ADS)

Dispenza, Massimiliano; Fiorello, Annamaria; Secchi, Alberto; Varasi, Mauro

This chapter is an overview on terahertz technologies and applications for sensing. The most advanced imaging and spectroscopy techniques are described, considering current opportunities and limitations in comparison to probes in the adjacent regions of the e.m. spectrum. Potential applications are highlighted, with a specific focus on security for detection of illicit substances and revealing of hidden objects. The technological status and current bottlenecks on sources and detectors are reviewed and future trends discussed.

Shale gas, wind and water: assessing the potential cumulative impacts of energy development on ecosystem services within the Marcellus play.

PubMed

Evans, Jeffrey S; Kiesecker, Joseph M

2014-01-01

Global demand for energy has increased by more than 50 percent in the last half-century, and a similar increase is projected by 2030. This demand will increasingly be met with alternative and unconventional energy sources. Development of these resources causes disturbances that strongly impact terrestrial and freshwater ecosystems. The Marcellus Shale gas play covers more than 160,934 km(2) in an area that provides drinking water for over 22 million people in several of the largest metropolitan areas in the United States (e.g. New York City, Washington DC, Philadelphia & Pittsburgh). Here we created probability surfaces representing development potential of wind and shale gas for portions of six states in the Central Appalachians. We used these predictions and published projections to model future energy build-out scenarios to quantify future potential impacts on surface drinking water. Our analysis predicts up to 106,004 new wells and 10,798 new wind turbines resulting up to 535,023 ha of impervious surface (3% of the study area) and upwards of 447,134 ha of impacted forest (2% of the study area). In light of this new energy future, mitigating the impacts of energy development will be one of the major challenges in the coming decades.

Shale Gas, Wind and Water: Assessing the Potential Cumulative Impacts of Energy Development on Ecosystem Services within the Marcellus Play

PubMed Central

Evans, Jeffrey S.; Kiesecker, Joseph M.

2014-01-01

Global demand for energy has increased by more than 50 percent in the last half-century, and a similar increase is projected by 2030. This demand will increasingly be met with alternative and unconventional energy sources. Development of these resources causes disturbances that strongly impact terrestrial and freshwater ecosystems. The Marcellus Shale gas play covers more than 160,934 km2 in an area that provides drinking water for over 22 million people in several of the largest metropolitan areas in the United States (e.g. New York City, Washington DC, Philadelphia & Pittsburgh). Here we created probability surfaces representing development potential of wind and shale gas for portions of six states in the Central Appalachians. We used these predictions and published projections to model future energy build-out scenarios to quantify future potential impacts on surface drinking water. Our analysis predicts up to 106,004 new wells and 10,798 new wind turbines resulting up to 535,023 ha of impervious surface (3% of the study area) and upwards of 447,134 ha of impacted forest (2% of the study area). In light of this new energy future, mitigating the impacts of energy development will be one of the major challenges in the coming decades. PMID:24586599

Challenge, Change and Opportunity: Overview, Texts and Agenda.

ERIC Educational Resources Information Center

Runnymede Trust, London (England).

"The Future of Multi-Ethnic Britain: Challenges, Changes, and Opportunities" was a conference organized by the Runnymede Trust in partnership with other organizations to consider changes in multiethnic Britain in recent years, principal challenges and opportunities for the future, and what to do about them. These issues were discussed in…

The Therapeutic Potential of Anti-Inflammatory Exerkines in the Treatment of Atherosclerosis

PubMed Central

Yu, Megan; Tsai, Sheng-Feng; Kuo, Yu-Min

2017-01-01

Although many cardiovascular (CVD) medications, such as antithrombotics, statins, and antihypertensives, have been identified to treat atherosclerosis, at most, many of these therapeutic agents only delay its progression. A growing body of evidence suggests physical exercise could be implemented as a non-pharmacologic treatment due to its pro-metabolic, multisystemic, and anti-inflammatory benefits. Specifically, it has been discovered that certain anti-inflammatory peptides, metabolites, and RNA species (collectively termed “exerkines”) are released in response to exercise that could facilitate these benefits and could serve as potential therapeutic targets for atherosclerosis. However, much of the relationship between exercise and these exerkines remains unanswered, and there are several challenges in the discovery and validation of these exerkines. This review primarily highlights major anti-inflammatory exerkines that could serve as potential therapeutic targets for atherosclerosis. To provide some context and comparison for the therapeutic potential of exerkines, the anti-inflammatory, multisystemic benefits of exercise, the basic mechanisms of atherosclerosis, and the limited efficacies of current anti-inflammatory therapeutics for atherosclerosis are briefly summarized. Finally, key challenges and future directions for exploiting these exerkines in the treatment of atherosclerosis are discussed. PMID:28608819

Immunotherapy in prostate cancer: challenges and opportunities.

PubMed

Noguchi, Masanori; Koga, Noriko; Moriya, Fukuko; Itoh, Kyogo

2016-01-01

Although treatment options for castration-resistant prostate cancer (CRPC) have increased over the last decade, there remains a need for strategies that can provide durable disease control and long-term benefit. Recently, immunotherapy has emerged as a viable and attractive strategy for the treatment of CRPC. To date, there are multiple strategies to target the immune system, and several approaches including therapeutic cancer vaccines and immune checkpoint inhibitors have been most successful in clinical trials. With regard to this, we report the results of the most recent clinical trials investigating immunotherapy in CRPC and discuss the future development of immunotherapy for CRPC, as well as the potential importance of biomarkers in the future progress of this field.

Human Exploration of Mars Design Reference Architecture 5.0

NASA Technical Reports Server (NTRS)

Drake, Bret G.

2010-01-01

This paper provides a summary of the Mars Design Reference Architecture 5.0 (DRA 5.0), which is the latest in a series of NASA Mars reference missions. It provides a vision of one potential approach to human Mars exploration. The reference architecture provides a common framework for future planning of systems concepts, technology development, and operational testing as well as Mars robotic missions, research that is conducted on the International Space Station, and future lunar exploration missions. This summary the Mars DRA 5.0 provides an overview of the overall mission approach, surface strategy and exploration goals, as well as the key systems and challenges for the first three human missions to Mars.

Exploring a model-driven architecture (MDA) approach to health care information systems development.

PubMed

Raghupathi, Wullianallur; Umar, Amjad

2008-05-01

To explore the potential of the model-driven architecture (MDA) in health care information systems development. An MDA is conceptualized and developed for a health clinic system to track patient information. A prototype of the MDA is implemented using an advanced MDA tool. The UML provides the underlying modeling support in the form of the class diagram. The PIM to PSM transformation rules are applied to generate the prototype application from the model. The result of the research is a complete MDA methodology to developing health care information systems. Additional insights gained include development of transformation rules and documentation of the challenges in the application of MDA to health care. Design guidelines for future MDA applications are described. The model has the potential for generalizability. The overall approach supports limited interoperability and portability. The research demonstrates the applicability of the MDA approach to health care information systems development. When properly implemented, it has the potential to overcome the challenges of platform (vendor) dependency, lack of open standards, interoperability, portability, scalability, and the high cost of implementation.

The Inter-Life project: researching the potential of art, design and virtual worlds as a vehicle for assisting young people with key life changes and transitions.

PubMed

Lally, Victor; Sclater, Madeleine

2013-06-01

Careers work in the twenty-first century faces a key challenge in terms of digital technologies: to evaluate their potential for careers work in challenging settings. Given the rapidity of developments, technologies require evaluation in research innovations and naturalistic settings. Virtual worlds offer potential for careers and guidance work, and the therapeutic domain. To illustrate this, we present examples in which young people explore their feelings and ideas, plans and difficulties, while preparing for film-making. During this they develop important life transition skills. We argue that the power of virtual worlds - to support emotional and cognitive engagement - could be utilised in practice settings. We conclude that they are serious candidates as digital tools in the careers and guidance domain. We need intermediate runaway objects which are less spectacular and more inviting… bringing together the big and the small, the impossible and the possible, the future-oriented activity level vision and the here and now consequential action. (Engeström, 2009, p. 305 and p. 328).

The Inter-Life project: researching the potential of art, design and virtual worlds as a vehicle for assisting young people with key life changes and transitions

PubMed Central

Lally, Victor; Sclater, Madeleine

2013-01-01

Careers work in the twenty-first century faces a key challenge in terms of digital technologies: to evaluate their potential for careers work in challenging settings. Given the rapidity of developments, technologies require evaluation in research innovations and naturalistic settings. Virtual worlds offer potential for careers and guidance work, and the therapeutic domain. To illustrate this, we present examples in which young people explore their feelings and ideas, plans and difficulties, while preparing for film-making. During this they develop important life transition skills. We argue that the power of virtual worlds – to support emotional and cognitive engagement – could be utilised in practice settings. We conclude that they are serious candidates as digital tools in the careers and guidance domain. We need intermediate runaway objects which are less spectacular and more inviting… bringing together the big and the small, the impossible and the possible, the future-oriented activity level vision and the here and now consequential action. (Engeström, 2009, p. 305 and p. 328) PMID:24009408

Identifying Future Disease Hot Spots: Infectious Disease Vulnerability Index.

PubMed

Moore, Melinda; Gelfeld, Bill; Okunogbe, Adeyemi; Paul, Christopher

2017-06-01

Recent high-profile outbreaks, such as Ebola and Zika, have illustrated the transnational nature of infectious diseases. Countries that are most vulnerable to such outbreaks might be higher priorities for technical support. RAND created the Infectious Disease Vulnerability Index to help U.S. government and international agencies identify these countries and thereby inform programming to preemptively help mitigate the spread and effects of potential transnational outbreaks. The authors employed a rigorous methodology to identify the countries most vulnerable to disease outbreaks. They conducted a comprehensive review of relevant literature to identify factors influencing infectious disease vulnerability. Using widely available data, the authors created an index for identifying potentially vulnerable countries and then ranked countries by overall vulnerability score. Policymakers should focus on the 25 most-vulnerable countries with an eye toward a potential "disease belt" in the Sahel region of Africa. The infectious disease vulnerability scores for several countries were better than what would have been predicted on the basis of economic status alone. This suggests that low-income countries can overcome economic challenges and become more resilient to public health challenges, such as infectious disease outbreaks.

Challenges of NDE Simulation Tool Challenges of NDE Simulation Tool

NASA Technical Reports Server (NTRS)

Leckey, Cara A. C.; Juarez, Peter D.; Seebo, Jeffrey P.; Frank, Ashley L.

2015-01-01

Realistic nondestructive evaluation (NDE) simulation tools enable inspection optimization and predictions of inspectability for new aerospace materials and designs. NDE simulation tools may someday aid in the design and certification of advanced aerospace components; potentially shortening the time from material development to implementation by industry and government. Furthermore, modeling and simulation are expected to play a significant future role in validating the capabilities and limitations of guided wave based structural health monitoring (SHM) systems. The current state-of-the-art in ultrasonic NDE/SHM simulation cannot rapidly simulate damage detection techniques for large scale, complex geometry composite components/vehicles with realistic damage types. This paper discusses some of the challenges of model development and validation for composites, such as the level of realism and scale of simulation needed for NASA' applications. Ongoing model development work is described along with examples of model validation studies. The paper will also discuss examples of the use of simulation tools at NASA to develop new damage characterization methods, and associated challenges of validating those methods.

MO-B-16A-02: In Memoriam of Donald D. Tolbert: Surviving the Politics of Radiation Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bayouth, J; Limmer, J

Today's healthcare work environment is ever-changing and without a doubt will continue to do so for the foreseeable future. How physicists are employed, evaluated, and valued are important aspects of our careers. With increasing demands and challenges being placed on the medical physics workforce, it is important to have the skills and knowledge to prepare for potential challenges to the status-quo of our employment status. Surviving in a world of change, consolidation, increased workload, and financial constraints is not a given, and preparing for those changes and challenges will benefit individuals as well as the medical physics community at large.more » Learning Objectives: Understand the challenges of succeeding in different work environments. Learn strategies to help define the role of a medical physicist to various administrators, physicians, and department staff and directors. Learn how to successfully communicate and interact with University, Hospital, and Department administrators.« less

Transit Spectroscopy of Biosignature Gases: Prospects and Challenges

NASA Astrophysics Data System (ADS)

Domagal-Goldman, Shawn David; Arney, Giada; Meadows, Victoria; Virtual Planetary Laboratory, Sellers Exoplanet Environments Collaboration

2018-01-01

Transit spectroscopy should provide astronomers with their first opportunities to search for signs of life on exoplanets: first with JWST, then with ground-based extremely large telescopes, and eventually with purpose-designed missions such as the Origins Space Telescope. However, given this exciting opportunity, there are challenges to observing these signatures. The transit observation technique will carry observational biases towards planets orbiting cool (M-type) stars. These planets have challenges for habitability, including the potential for tidal locking and for planetary atmospheres to be loss to high-energy radiation from the host star. These observations will also have a bias towards spectral information from the uppermost of planetary atmospheres, where strictly abiotic photochemical processes can efficiently produce some biosignature gases, in particular as oxygen and ozone. Here, we will discuss these challenges, and how future missions/telescopes can account for them in their instrument design and observation strategies. We will also discuss how, even if some of the concerns above are warranted, such observations are justified astrobiological explorations of rocky planets around other stars.

Adaptive Management: From More Talk to Real Action

NASA Astrophysics Data System (ADS)

Williams, Byron K.; Brown, Eleanor D.

2014-02-01

The challenges currently facing resource managers are large-scale and complex, and demand new approaches to balance development and conservation goals. One approach that shows considerable promise for addressing these challenges is adaptive management, which by now is broadly seen as a natural, intuitive, and potentially effective way to address decision-making in the face of uncertainties. Yet the concept of adaptive management continues to evolve, and its record of success remains limited. In this article, we present an operational framework for adaptive decision-making, and describe the challenges and opportunities in applying it to real-world problems. We discuss the key elements required for adaptive decision-making, and their integration into an iterative process that highlights and distinguishes technical and social learning. We illustrate the elements and processes of the framework with some successful on-the-ground examples of natural resource management. Finally, we address some of the difficulties in applying learning-based management, and finish with a discussion of future directions and strategic challenges.

Trends, Opportunities, and Challenges for Tall Wind Turbine and Tower Technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lantz, Eric; Roberts, Owen; Dykes, Katherine

This presentation summarizes recent analysis focused on characterizing the opportunity for Tall Wind technologies generally and for tall tower technologies specifically. It seeks to illuminate and explain the concept of Tall Wind, its impact on the wind industry to date, and the potential value of Tall Wind in the future. It also explores the conditions and locations under which the impacts of Tall Wind offer the most significant potential to increase wind technology performance. In addition, it seeks to examine the status of tall tower technology as a key sub-component of Tall Wind, focusing on the potential for continued innovationmore » in tubular steel wind turbine towers and the status and potential for a select set of alternative tall tower technologies.« less

Semantic Web Services Challenge, Results from the First Year. Series: Semantic Web And Beyond, Volume 8.

NASA Astrophysics Data System (ADS)

Petrie, C.; Margaria, T.; Lausen, H.; Zaremba, M.

Explores trade-offs among existing approaches. Reveals strengths and weaknesses of proposed approaches, as well as which aspects of the problem are not yet covered. Introduces software engineering approach to evaluating semantic web services. Service-Oriented Computing is one of the most promising software engineering trends because of the potential to reduce the programming effort for future distributed industrial systems. However, only a small part of this potential rests on the standardization of tools offered by the web services stack. The larger part of this potential rests upon the development of sufficient semantics to automate service orchestration. Currently there are many different approaches to semantic web service descriptions and many frameworks built around them. A common understanding, evaluation scheme, and test bed to compare and classify these frameworks in terms of their capabilities and shortcomings, is necessary to make progress in developing the full potential of Service-Oriented Computing. The Semantic Web Services Challenge is an open source initiative that provides a public evaluation and certification of multiple frameworks on common industrially-relevant problem sets. This edited volume reports on the first results in developing common understanding of the various technologies intended to facilitate the automation of mediation, choreography and discovery for Web Services using semantic annotations. Semantic Web Services Challenge: Results from the First Year is designed for a professional audience composed of practitioners and researchers in industry. Professionals can use this book to evaluate SWS technology for their potential practical use. The book is also suitable for advanced-level students in computer science.

Assessment approaches in massive open online courses: Possibilities, challenges and future directions

NASA Astrophysics Data System (ADS)

Xiong, Yao; Suen, Hoi K.

2018-03-01

The development of massive open online courses (MOOCs) has launched an era of large-scale interactive participation in education. While massive open enrolment and the advances of learning technology are creating exciting potentials for lifelong learning in formal and informal ways, the implementation of efficient and effective assessment is still problematic. To ensure that genuine learning occurs, both assessments for learning (formative assessments), which evaluate students' current progress, and assessments of learning (summative assessments), which record students' cumulative progress, are needed. Providers' more recent shift towards the granting of certificates and digital badges for course accomplishments also indicates the need for proper, secure and accurate assessment results to ensure accountability. This article examines possible assessment approaches that fit open online education from formative and summative assessment perspectives. The authors discuss the importance of, and challenges to, implementing assessments of MOOC learners' progress for both purposes. Various formative and summative assessment approaches are then identified. The authors examine and analyse their respective advantages and disadvantages. They conclude that peer assessment is quite possibly the only universally applicable approach in massive open online education. They discuss the promises, practical and technical challenges, current developments in and recommendations for implementing peer assessment. They also suggest some possible future research directions.

Challenges of a community based pragmatic, randomised controlled trial of weight loss maintenance.

PubMed

Randell, Elizabeth; McNamara, Rachel; Shaw, Christine; Espinasse, Aude; Simpson, Sharon Anne

2015-12-18

Randomised controlled trials (RCTs) have a reputation for being inherently difficult to deliver as planned and often face unforeseen challenges and delays, particularly in relation to organisational and governance difficulties, participant interest, constraints due to allocation of costs, local investigator interest and lengthy bureaucracy. Recruitment is often difficult and the challenges faced often impact on the cost and delivery of a successful trial within the funded period. This paper reflects upon the challenges faced in delivering a pragmatic RCT of weight loss maintenance in a community setting and suggests some potential solutions. The weight loss maintenance in adults trial aimed to evaluate the impact of a 12 month, individually tailored weight maintenance intervention on BMI 3 years from randomisation. Participants were recruited primarily from participant identification centres (PICs)-GP surgeries, exercise on referral schemes and slimming world. The intervention was delivered in community settings. A recruitment strategy implementation plan was drafted to address and monitor poor recruitment. Delays in opening and recruitment were experienced early on. Some were beyond the control of the study team such as; disagreement over allocation of national health service costs and PIC classification as well as difficulties in securing support from research networks. That the intervention was delivered in community settings was often at the root of these issues. Key items to address at the design stage of future trials include feasibility of eligibility criteria. The most effective element of the recruitment implementation plan was to refocus sources of recruitment and target only those who could fulfil the eligibility criteria immediately. Learnings from this trial should be kept in mind by those designing similar studies in the future. Considering potential governance, cost and research network support implications at the design stage of pragmatic trials of any community-based complex intervention is paramount. The appropriateness and viability of inclusion criteria also require careful consideration as does use of a targeted advertising strategy. ISRCTN35774128, 12/01/2010.

Biodiversity scenarios neglect future land-use changes.

PubMed

Titeux, Nicolas; Henle, Klaus; Mihoub, Jean-Baptiste; Regos, Adrián; Geijzendorffer, Ilse R; Cramer, Wolfgang; Verburg, Peter H; Brotons, Lluís

2016-07-01

Efficient management of biodiversity requires a forward-looking approach based on scenarios that explore biodiversity changes under future environmental conditions. A number of ecological models have been proposed over the last decades to develop these biodiversity scenarios. Novel modelling approaches with strong theoretical foundation now offer the possibility to integrate key ecological and evolutionary processes that shape species distribution and community structure. Although biodiversity is affected by multiple threats, most studies addressing the effects of future environmental changes on biodiversity focus on a single threat only. We examined the studies published during the last 25 years that developed scenarios to predict future biodiversity changes based on climate, land-use and land-cover change projections. We found that biodiversity scenarios mostly focus on the future impacts of climate change and largely neglect changes in land use and land cover. The emphasis on climate change impacts has increased over time and has now reached a maximum. Yet, the direct destruction and degradation of habitats through land-use and land-cover changes are among the most significant and immediate threats to biodiversity. We argue that the current state of integration between ecological and land system sciences is leading to biased estimation of actual risks and therefore constrains the implementation of forward-looking policy responses to biodiversity decline. We suggest research directions at the crossroads between ecological and environmental sciences to face the challenge of developing interoperable and plausible projections of future environmental changes and to anticipate the full range of their potential impacts on biodiversity. An intergovernmental platform is needed to stimulate such collaborative research efforts and to emphasize the societal and political relevance of taking up this challenge. © 2016 John Wiley & Sons Ltd.

Predicting evolutionary responses to climate change in the sea.

PubMed

Munday, Philip L; Warner, Robert R; Monro, Keyne; Pandolfi, John M; Marshall, Dustin J

2013-12-01

An increasing number of short-term experimental studies show significant effects of projected ocean warming and ocean acidification on the performance on marine organisms. Yet, it remains unclear if we can reliably predict the impact of climate change on marine populations and ecosystems, because we lack sufficient understanding of the capacity for marine organisms to adapt to rapid climate change. In this review, we emphasise why an evolutionary perspective is crucial to understanding climate change impacts in the sea and examine the approaches that may be useful for addressing this challenge. We first consider what the geological record and present-day analogues of future climate conditions can tell us about the potential for adaptation to climate change. We also examine evidence that phenotypic plasticity may assist marine species to persist in a rapidly changing climate. We then outline the various experimental approaches that can be used to estimate evolutionary potential, focusing on molecular tools, quantitative genetics, and experimental evolution, and we describe the benefits of combining different approaches to gain a deeper understanding of evolutionary potential. Our goal is to provide a platform for future research addressing the evolutionary potential for marine organisms to cope with climate change. © 2013 John Wiley & Sons Ltd/CNRS.

[Migration. Opportunities for recruitment of skilled employees in the care sector].

PubMed

Braeseke, G; Merda, M; Bauer, T K; Otten, S; Stroka, M A; Talmann, A E

2013-08-01

A central objective of this study was to estimate the potential workforce for the elderly care sector in Germany and to compare it with the predicted demand for nurses in 2030. The authors describe the opportunities and obstacles in recruiting skilled professionals from EU member states and from countries outside the EU. Different scenarios of how to raise labor input are discussed so as to determine the domestic potential until 2030 in Germany. The results show that only by assuming unrealistic conditions, e. g., expectations of a high full-time working quota or far more working women, can the domestic potential meet the predicted future demands. Therefore, Germany's chances of attracting skilled foreign workers were assessed by analyzing wage differentials, unemployment probabilities, demographic developments, and professional and cultural aspects between the countries. A major finding study is that the German labor market cannot provide enough nursing care professionals for the elderly care sector by 2030. Secondly, most of the other EU member states are facing similar challenges, at least in the long run. Therefore, it is recommendable to intensify collaboration with populous Asian countries in the future.

Capacity Building for School Development: Current Problems and Future Challenges

ERIC Educational Resources Information Center

Ho, Dora; Lee, Moosung

2016-01-01

This article offers a theoretical discussion on the current problems and future challenges of school capacity building in early childhood education (ECE), aiming to highlight some key areas for future research. In recent years, there has been a notable policy shift from monitoring quality through inspection to improving quality through school…

WE-H-BRB-03: Learning Health Systems for Radiation Oncology: Needs and Challenges for Future Success

DOE Office of Scientific and Technical Information (OSTI.GOV)

McNutt, T.

Big Data in Radiation Oncology: (1) Overview of the NIH 2015 Big Data Workshop, (2) Where do we stand in the applications of big data in radiation oncology?, and (3) Learning Health Systems for Radiation Oncology: Needs and Challenges for Future Success The overriding goal of this trio panel of presentations is to improve awareness of the wide ranging opportunities for big data impact on patient quality care and enhancing potential for research and collaboration opportunities with NIH and a host of new big data initiatives. This presentation will also summarize the Big Data workshop that was held at themore » NIH Campus on August 13–14, 2015 and sponsored by AAPM, ASTRO, and NIH. The workshop included discussion of current Big Data cancer registry initiatives, safety and incident reporting systems, and other strategies that will have the greatest impact on radiation oncology research, quality assurance, safety, and outcomes analysis. Learning Objectives: To discuss current and future sources of big data for use in radiation oncology research To optimize our current data collection by adopting new strategies from outside radiation oncology To determine what new knowledge big data can provide for clinical decision support for personalized medicine L. Xing, NIH/NCI Google Inc.« less

Future clinical challenges in multiple sclerosis: Relevance to sphingosine 1-phosphate receptor modulator therapy.

PubMed

Hohlfeld, Reinhard; Barkhof, Frederik; Polman, Chris

2011-02-22

The limitations of established therapies for multiple sclerosis (MS) are well-known and include the need for injections, treatment adherence and convenience issues, partial efficacy, and, in some cases, a risk of potentially life-threatening adverse events, such as progressive multifocal leukoencephalopathy. Recently, attention has focused on developing more effective therapies that are administered orally and target neurodegeneration as well as inflammation. In this review, we provide an outlook on the future clinical challenges for MS treatment and management, and focus specifically on the emerging sphingosine 1-phosphate receptor (S1PR) modulators. We highlight the importance of improving our understanding of the neurobiological basis of MS to develop well-tolerated targeted therapies and the need to include advanced MRI assessments that quantify neurodegeneration in interventional studies in MS. As more treatments become available, often with complex pharmacodynamic actions, objective assessment of benefit-to-risk profiles becomes increasingly important to ensure that patients receive appropriate care. Pharmacovigilance and immune monitoring will become important aspects of patient treatment and management in the future. With respect to S1PR modulation, we review the experimental agents that are in clinical development for MS and summarize the steps taken in postmarketing surveillance to ensure that fingolimod (FTY720) has a well-characterized safety profile.

Nanomaterials for Polymer Electrolyte Membrane Fuel Cells; Materials Challenges Facing Electrical Energy Storate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gopal Rao, MRS Web-Editor; Yury Gogotsi, Drexel University; Karen Swider-Lyons, Naval Research Laboratory

Symposium T: Nanomaterials for Polymer Electrolyte Membrane Fuel Cells Polymer electrolyte membrane (PEM) fuel cells are under intense investigation worldwide for applications ranging from transportation to portable power. The purpose of this seminar is to focus on the nanomaterials and nanostructures inherent to polymer fuel cells. Symposium topics will range from high-activity cathode and anode catalysts, to theory and new analytical methods. Symposium U: Materials Challenges Facing Electrical Energy Storage Electricity, which can be generated in a variety of ways, offers a great potential for meeting future energy demands as a clean and efficient energy source. However, the use ofmore » electricity generated from renewable sources, such as wind or sunlight, requires efficient electrical energy storage. This symposium will cover the latest material developments for batteries, advanced capacitors, and related technologies, with a focus on new or emerging materials science challenges.« less

Climate Change and Health in the Urban Context: The Experience of Barcelona.

PubMed

Villalbí, Joan R; Ventayol, Irma

2016-07-01

Climate change poses huge challenges for public health, and cities are at the forefront of this process. The purpose of this paper is to present the issues climate change poses for public health in the city of Barcelona, how they are being addressed, and what are the current major challenges, trying to contribute to the development of a baseline understanding of the status of adaptation in cities from a public health perspective. The major issues related to climate change faced by the city are common to other urban centers in a Mediterranean climate: heat waves, water availability and quality, air quality, and diseases transmitted by vectors, and all are reviewed in detail with empirical data. They are not a potential threat for the future, but have actually challenged the city services and infrastructure over the last years, requiring sustainable responses and rigorous planning. © The Author(s) 2016.

The Sustainable Development of Space: Astro-environmental and dynamical considerations

NASA Astrophysics Data System (ADS)

Boley, Aaron; Byers, Michael; Russell, Sara

2018-04-01

The sustainable development of space is a global (and exo-global) challenge that is not limited by borders or research disciplines. Sustainable development is "development that meets the needs of the present without compromising the ability of future generations to meet their own needs". While the development of space brings new economic and scientific possibilities, it also carries significant political, legal, and technical uncertainties. For example, the rapidly increasing accessibility of space is motivating states to unilaterally adopt legislation for the new era of space use, which may have significant unintended consequences, such as increased risks to space assets, disputes among state as well as non-state actors, and changes to unique astro-environments. Any policy or legal position must be informed by the dynamical and astrophysical realities of space use, creating complex and interwoven challenges. Here, we explore several of these potential challenges related to astro-environmentalism, space minining operations, and the associated dynamics.

Molecular basis of high viscosity in concentrated antibody solutions: Strategies for high concentration drug product development.

PubMed

Tomar, Dheeraj S; Kumar, Sandeep; Singh, Satish K; Goswami, Sumit; Li, Li

2016-01-01

Effective translation of breakthrough discoveries into innovative products in the clinic requires proactive mitigation or elimination of several drug development challenges. These challenges can vary depending upon the type of drug molecule. In the case of therapeutic antibody candidates, a commonly encountered challenge is high viscosity of the concentrated antibody solutions. Concentration-dependent viscosity behaviors of mAbs and other biologic entities may depend on pairwise and higher-order intermolecular interactions, non-native aggregation, and concentration-dependent fluctuations of various antibody regions. This article reviews our current understanding of molecular origins of viscosity behaviors of antibody solutions. We discuss general strategies and guidelines to select low viscosity candidates or optimize lead candidates for lower viscosity at early drug discovery stages. Moreover, strategies for formulation optimization and excipient design are also presented for candidates already in advanced product development stages. Potential future directions for research in this field are also explored.

Challenges of assessing the clinical efficacy of asexual blood-stage Plasmodium falciparum malaria vaccines.

PubMed

Sheehy, Susanne H; Douglas, Alexander D; Draper, Simon J

2013-09-01

In the absence of any highly effective vaccine candidate against Plasmodium falciparum malaria, it remains imperative for the field to pursue all avenues that may lead to the successful development of such a formulation. The development of a subunit vaccine targeting the asexual blood-stage of Plasmodium falciparum malaria infection has proven particularly challenging with only limited success to date in clinical trials. However, only a fraction of potential blood-stage vaccine antigens have been evaluated as targets, and a number of new promising candidate antigen formulations and delivery platforms are approaching clinical development. It is therefore essential that reliable and sensitive methods of detecting, or ruling out, even modest efficacy of blood-stage vaccines in small clinical trials be established. In this article we evaluate the challenges facing blood-stage vaccine developers, assess the appropriateness and limitations of various in vivo approaches for efficacy assessment and suggest future directions for the field.

Challenges and perspectives in quantitative NMR.

PubMed

Giraudeau, Patrick

2017-01-01

This perspective article summarizes, from the author's point of view at the beginning of 2016, the major challenges and perspectives in the field of quantitative NMR. The key concepts in quantitative NMR are first summarized; then, the most recent evolutions in terms of resolution and sensitivity are discussed, as well as some potential future research directions in this field. A particular focus is made on methodologies capable of boosting the resolution and sensitivity of quantitative NMR, which could open application perspectives in fields where the sample complexity and the analyte concentrations are particularly challenging. These include multi-dimensional quantitative NMR and hyperpolarization techniques such as para-hydrogen-induced polarization or dynamic nuclear polarization. Because quantitative NMR cannot be dissociated from the key concepts of analytical chemistry, i.e. trueness and precision, the methodological developments are systematically described together with their level of analytical performance. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

An Overview of Metallic Nanowire Networks, Promising Building Blocks for Next Generation Transparent Conductors: Emergence, Fundamentals and Challenges

NASA Astrophysics Data System (ADS)

Pirsalami, Sedigheh; Zebarjad, Seyed Mojtaba; Daneshmanesh, Habib

2017-08-01

Transparent conductors (TCs) have a wide range of applications in numerous electronic and optoelectronic devices. This review provides an overview of the emergence of metallic nanowire networks (MNNs) as promising building blocks for the next generation transparent conductors. The fundamental aspects, structure-property relations, fabrication techniques and the corresponding challenges are reviewed. Theoretical and experimental researches suggest that nanowires with smaller diameter, longer length and higher aspect ratio have higher performance. Yet, the development of an efficient synthesis technique for the production of MNNs has remained a challenge. The synthesis method is also crucial to the scalability and the commercial potential of these emerging TCs. The most promising techniques for the synthesis together with their advantages, limitations and the recent findings are here discussed. Finally, we will try to show the promising future research trends in MNNs to have an approach to design the next generation TCs.

Internet of Things in Higher Education: A Study on Future Learning

NASA Astrophysics Data System (ADS)

Aldowah, Hanan; Rehman, Shafiq Ul; Ghazal, Samar; Naufal Umar, Irfan

2017-09-01

In the coming years, technology will impact the learning experience in many ways. Internet of Things (IoT) continues to confirm its important position in the context of Information and Communication Technologies and the development of society. With the support of IoT, institutions can enhance learning outcomes by providing more affluent learning experiences, improved operational efficiency, and by gaining real-time, actionable insight into student performance. The purpose of this study is to find out the potential of IoT in higher education and how to maximize its benefits and reducing the risks involved with it. Further efforts are necessary for releasing the full potential of IoT systems and technologies. Therefore, this paper presents a study about the impact of IoT on higher education especially universities. IoT stands to change dramatically the way universities work, and enhance student learning in many disciplines and at any level. It has huge potential for universities or any other educational institutions; if well prepared to ensure widespread and successful implementation by leadership, staff, and students. IoT needs development where universities can lead. Academics, researchers, and students are in a unique place to lead the discovery and development of IoT systems, devices, applications, and services. Moreover, this paper provides an evidences about the future of IoT in the higher education during the next few years, which have offered by a number of research organizations and enterprises. On the other hand, IoT also brings tremendous challenges to higher education. Hence, this paper also presents the perspective on the challenges of IoT in higher education.

Harnessing the potential of natural products in drug discovery from a cheminformatics vantage point.

PubMed

Rodrigues, Tiago

2017-11-15

Natural products (NPs) present a privileged source of inspiration for chemical probe and drug design. Despite the biological pre-validation of the underlying molecular architectures and their relevance in drug discovery, the poor accessibility to NPs, complexity of the synthetic routes and scarce knowledge of their macromolecular counterparts in phenotypic screens still hinder their broader exploration. Cheminformatics algorithms now provide a powerful means of circumventing the abovementioned challenges and unlocking the full potential of NPs in a drug discovery context. Herein, I discuss recent advances in the computer-assisted design of NP mimics and how artificial intelligence may accelerate future NP-inspired molecular medicine.

Carbon Nanotubes as Optical Sensors in Biomedicine.

PubMed

Farrera, Consol; Torres Andón, Fernando; Feliu, Neus

2017-11-28

Single-walled carbon nanotubes (SWCNTs) have become potential candidates for a wide range of medical applications including sensing, imaging, and drug delivery. Their photophysical properties (i.e., the capacity to emit in the near-infrared), excellent photostability, and fluorescence, which is highly sensitive to the local environment, make SWCNTs promising optical probes in biomedicine. In this Perspective, we discuss the existing strategies for and challenges of using carbon nanotubes for medical diagnosis based on intracellular sensing as well as discuss also their biocompatibility and degradability. Finally, we highlight the potential improvements of this nanotechnology and future directions in the field of carbon nanotubes for biomedical applications.

Computational predictions of zinc oxide hollow structures

NASA Astrophysics Data System (ADS)

Tuoc, Vu Ngoc; Huan, Tran Doan; Thao, Nguyen Thi

2018-03-01

Nanoporous materials are emerging as potential candidates for a wide range of technological applications in environment, electronic, and optoelectronics, to name just a few. Within this active research area, experimental works are predominant while theoretical/computational prediction and study of these materials face some intrinsic challenges, one of them is how to predict porous structures. We propose a computationally and technically feasible approach for predicting zinc oxide structures with hollows at the nano scale. The designed zinc oxide hollow structures are studied with computations using the density functional tight binding and conventional density functional theory methods, revealing a variety of promising mechanical and electronic properties, which can potentially find future realistic applications.

Methodological Challenges in Studies Examining the Effects of Breakfast on Cognitive Performance and Appetite in Children and Adolescents.

PubMed

Adolphus, Katie; Bellissimo, Nick; Lawton, Clare L; Ford, Nikki A; Rains, Tia M; Totosy de Zepetnek, Julia; Dye, Louise

2017-01-01

Breakfast is purported to confer a number of benefits on diet quality, health, appetite regulation, and cognitive performance. However, new evidence has challenged the long-held belief that breakfast is the most important meal of the day. This review aims to provide a comprehensive discussion of the key methodological challenges and considerations in studies assessing the effect of breakfast on cognitive performance and appetite control, along with recommendations for future research. This review focuses on the myriad challenges involved in studying children and adolescents specifically. Key methodological challenges and considerations include study design and location, sampling and sample section, choice of objective cognitive tests, choice of objective and subjective appetite measures, merits of providing a fixed breakfast compared with ad libitum, assessment and definition of habitual breakfast consumption, transparency of treatment condition, difficulty of isolating the direct effects of breakfast consumption, untangling acute and chronic effects, and influence of confounding variables. These methodological challenges have hampered a clear substantiation of the potential positive effects of breakfast on cognition and appetite control and contributed to the debate questioning the notion that breakfast is the most important meal of the day. © 2017 American Society for Nutrition.

Methodological Challenges in Studies Examining the Effects of Breakfast on Cognitive Performance and Appetite in Children and Adolescents123

PubMed Central

Bellissimo, Nick; Ford, Nikki A; Rains, Tia M

2017-01-01

Breakfast is purported to confer a number of benefits on diet quality, health, appetite regulation, and cognitive performance. However, new evidence has challenged the long-held belief that breakfast is the most important meal of the day. This review aims to provide a comprehensive discussion of the key methodological challenges and considerations in studies assessing the effect of breakfast on cognitive performance and appetite control, along with recommendations for future research. This review focuses on the myriad challenges involved in studying children and adolescents specifically. Key methodological challenges and considerations include study design and location, sampling and sample section, choice of objective cognitive tests, choice of objective and subjective appetite measures, merits of providing a fixed breakfast compared with ad libitum, assessment and definition of habitual breakfast consumption, transparency of treatment condition, difficulty of isolating the direct effects of breakfast consumption, untangling acute and chronic effects, and influence of confounding variables. These methodological challenges have hampered a clear substantiation of the potential positive effects of breakfast on cognition and appetite control and contributed to the debate questioning the notion that breakfast is the most important meal of the day. PMID:28096143

Polymer Nanocomposites—A Comparison between Carbon Nanotubes, Graphene, and Clay as Nanofillers

PubMed Central

Bhattacharya, Mrinal

2016-01-01

Nanofilled polymeric matrices have demonstrated remarkable mechanical, electrical, and thermal properties. In this article we review the processing of carbon nanotube, graphene, and clay montmorillonite platelet as potential nanofillers to form nanocomposites. The various functionalization techniques of modifying the nanofillers to enable interaction with polymers are summarized. The importance of filler dispersion in the polymeric matrix is highlighted. Finally, the challenges and future outlook for nanofilled polymeric composites are presented. PMID:28773388

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seeley, E.J.

An apple orchard can be a very efficient mechanism for harvesting and storing energy in a usable form. The challenge is to define how the genetic, microclimatic, soil, water and cultural practice interactions limit the productive potential of apple plantings and at the same time to look ahead toward increasing the efficiency of the plant to assume continued increases in productivity for the future. Five papers were presented as summaries of some of the current and past research efforts into the factors affecting apple tree photosynthesis. (DP).

Geo-Environmental Change and the United States Military: How History Can Inform Future Arctic Operations

DTIC Science & Technology

2012-05-17

and the Northern Sea Route, extraction of potential oil and gas resources, and expanded fishing and tourism .‖ 6 The Arctic‘s vast natural resources...sudden and substantial increase in commercial shipping, marine tourism , and large passenger vessels in the Arctic poses significant challenges to the...security,‖ Huebert states that, ―Canada, Denmark, Norway, Russia and the United States have all either begun to rebuild their Arctic capabilities

Terawatt-scale photovoltaics: Trajectories and challenges

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haegel, Nancy M.; Margolis, Robert; Buonassisi, Tonio

The annual potential of solar energy far exceeds the world's total energy consumption. However, the vision of photovoltaics (PVs) providing a substantial fraction of global electricity generation and total energy demand is far from being realized. What technical, infrastructure, economic, and policy barriers need to be overcome for PVs to grow to the multiple terawatt (TW) scale? Here, we assess realistic future scenarios and make suggestions for a global agenda to move toward PVs at a multi-TW scale.

Terawatt-scale photovoltaics: Trajectories and challenges

DOE PAGES

Haegel, Nancy M.; Margolis, Robert; Buonassisi, Tonio; ...

2017-04-13

The annual potential of solar energy far exceeds the world's total energy consumption. However, the vision of photovoltaics (PVs) providing a substantial fraction of global electricity generation and total energy demand is far from being realized. What technical, infrastructure, economic, and policy barriers need to be overcome for PVs to grow to the multiple terawatt (TW) scale? Here, we assess realistic future scenarios and make suggestions for a global agenda to move toward PVs at a multi-TW scale.

Planetary protection, legal ambiguity and the decision making process for Mars sample return

NASA Technical Reports Server (NTRS)

Race, M. S.

1996-01-01

As scientists and mission planners develop planetary protection requirements for future Mars sample return missions, they must recognize the socio-political context in which decisions about the mission will be made and pay careful attention to public concerns about potential back contamination of Earth. To the extent that planetary protection questions are unresolved or unaddressed at the time of an actual mission, they offer convenient footholds for public challenges in both legal and decision making realms, over which NASA will have little direct control. In this paper, two particular non-scientific areas of special concern are discussed in detail: 1) legal issues and 2) the decision making process. Understanding these areas is critical for addressing legitimate public concerns as well as for fulfilling procedural requirements regardless whether sample return evokes public controversy. Legal issues with the potential to complicate future missions include: procedural review under National Environmental Policy Act (NEPA); uncertainty about institutional control and authority; conflicting regulations and overlapping jurisdictions; questions about international treaty obligations and large scale impacts; uncertanities about the nature of the organism; and constitutional and regulatory concerns about quarantine, public health and safety. In light of these important legal issues, it is critical that NASA consider the role and timing of public involvement in the decision making process as a way of anticipating problem areas and preparing for legitimate public questions and challenges to sample return missions.

Man, mind, and machine: the past and future of virtual reality simulation in neurologic surgery.

PubMed

Robison, R Aaron; Liu, Charles Y; Apuzzo, Michael L J

2011-11-01

To review virtual reality in neurosurgery, including the history of simulation and virtual reality and some of the current implementations; to examine some of the technical challenges involved; and to propose a potential paradigm for the development of virtual reality in neurosurgery going forward. A search was made on PubMed using key words surgical simulation, virtual reality, haptics, collision detection, and volumetric modeling to assess the current status of virtual reality in neurosurgery. Based on previous results, investigators extrapolated the possible integration of existing efforts and potential future directions. Simulation has a rich history in surgical training, and there are numerous currently existing applications and systems that involve virtual reality. All existing applications are limited to specific task-oriented functions and typically sacrifice visual realism for real-time interactivity or vice versa, owing to numerous technical challenges in rendering a virtual space in real time, including graphic and tissue modeling, collision detection, and direction of the haptic interface. With ongoing technical advancements in computer hardware and graphic and physical rendering, incremental or modular development of a fully immersive, multipurpose virtual reality neurosurgical simulator is feasible. The use of virtual reality in neurosurgery is predicted to change the nature of neurosurgical education, and to play an increased role in surgical rehearsal and the continuing education and credentialing of surgical practitioners. Copyright © 2011 Elsevier Inc. All rights reserved.

A review on alum sludge reuse with special reference to agricultural applications and future challenges.

PubMed

Dassanayake, K B; Jayasinghe, G Y; Surapaneni, A; Hetherington, C

2015-04-01

Alum salts are commonly used in the water industry to promote coagulation in the production of clean drinking water, which results in the generation and accumulation of 'waste' by-product 'alum sludge' in large volumes. Effective and efficient management of alum sludge in an economically and environmentally sustainable manner remains a significant social and environmental concern with ever increasing demand for potable water as a result of rapidly escalating world population and urban expansion. Various intensive practices have been employed to reuse the alum sludge in an attempt to figure out how to fill the gap between successful drinking water treatment process and environmentally friendly alum sludge management for over the years. This paper primarily aimed at comprehensive review of the existing literature on alum sludge characteristics, its environmental concerns and their potential utilization, especially in agricultural and horticultural sectors leading to update our recent state of knowledge and formulate a compendium of present and past developments. Different types of alum sludge utilizations in various fields were recognized and examined. The strengths, weaknesses, opportunities and potential risks of alum sludge reuse options with particular reference to agriculture were highlighted and knowledge gaps were identified. Research priorities and future challenges that will support in the development of effective alumsludgemanagement practices in agriculture with multi-prong strategies were discussed. Copyright © 2014 Elsevier Ltd. All rights reserved.

Perspectives from the NSF-sponsored workshop on Grand Challenges in Nanomaterials

NASA Astrophysics Data System (ADS)

Hull, Robert

2004-03-01

At an NSF-sponsored workshop in June 2003, about seventy research leaders in the field of nanomaterials met to discuss, explore and identify future new directions and critical needs ("Grand Challenges") for the next decade and beyond. The key pervasive theme that was identified was the need to develop techniques for assembly of nanoscaled materials over multiple lengths scales, at the levels of efficiency, economy, and precision necessary to realize broad new classes of applications in such diverse technologies as electronics, computation, telecommunications, data storage, energy storage / transmission / generation, health care, transportation, civil infrastructure, military applications, national security, and the environment. Elements of this strategy include development of new self-assembly and lithographic techniques; biologically-mediated synthesis; three-dimensional atomic-scale measurement of structure, properties and chemistry; harnessing of the sub-atomic properties of materials such as electron spin and quantum interactions; new computational methods that span all relevant length- and time- scales; a fundamental understanding of acceptable / achievable "fault tolerance" at the nanoscale; and methods for real-time and distributed sensing of nanoscale assembly. A parallel theme was the need to provide education concerning the potential, applications, and benefits of nanomaterials to all components of society and all levels of the educational spectrum. This talk will summarize the conclusions and recommendations from this workshop, and illustrate the future potential of this field through presentation of selected break-through results provided by workshop participants.

Potential Challenges of Controlling Leishmaniasis in Sri Lanka at a Disease Outbreak

PubMed Central

Gunawardana, Kithsiri; Rodrigo, Wasana

2017-01-01

The present works reviewed the existing information on leishmaniasis in Sri Lanka and in other countries, focusing on challenges of controlling leishmaniasis in the country, in an outbreak. Evidence from recent studies suggests that there is a possibility of a leishmaniasis outbreak in Sri Lanka in the near future. Difficulty of early diagnosis due to lack of awareness and unavailability or inadequacy of sensitive tests are two of the main challenges for effective case management. Furthermore, the absence of a proper drug for treatment and lack of knowledge about vector biology, distribution, taxonomy and bionomics, and reservoir hosts make the problem serious. The evident potential for visceralization in the cutaneous variant of L. donovani in Sri Lanka may also complicate the issue. Lack of knowledge among local communities also reduces the effectiveness of vector and reservoir host control programs. Immediate actions need to be taken in order to increase scientific knowledge about the disease and a higher effectiveness of the patient management and control programs must be achieved through increased awareness about the disease among general public and active participation of local community in control activities. PMID:28630867

Emerging Point-of-Care Technologies for Sickle Cell Disease Screening and Monitoring

PubMed Central

Alapan, Yunus; Fraiwan, Arwa; Kucukal, Erdem; Hasan, M. Noman; Ung, Ryan; Kim, Myeongseop; Odame, Isaac; Little, Jane A.; Gurkan, Umut A.

2016-01-01

Introduction Sickle Cell Disease (SCD) affects 100,000 Americans and more than 14 million people globally, mostly in economically disadvantaged populations, requires early diagnosis after birth and constant monitoring throughout the life-span of the patient. Areas Covered Early diagnosis of SCD still remains a challenge in preventing childhood mortality in the developing world due to requirements of skilled personnel and high-cost of currently available modalities. On the other hand, SCD monitoring presents insurmountable challenges due to heterogeneities among patient populations, as well as in the same individual longitudinally. Here, we describe emerging point-of-care micro/nano platform technologies for SCD screening and monitoring, and critically discuss current state-of-the-art, potential challenges associated with these technologies, and future directions. Expert Commentary Recently developed microtechnologies offer simple, rapid, and affordable screening of SCD and have the potential to facilitate universal screening in resource-limited settings and developing countries. On the other hand, monitoring of SCD is more complicated compared to diagnosis and requires comprehensive validation of efficacy. Early use of novel microdevices for patient monitoring might come in especially handy in new clinical trial designs of emerging therapies. PMID:27785945

Investigating the Feasibility of Utilizing Carbon Nanotube Fibers for Spacesuit Dust Mitigation

NASA Technical Reports Server (NTRS)

Manyapu, Kavya K.; de Leon, Pablo; Peltz, Leora; Tsentalovich, Dmitri; Gaier, James R.; Calle, Carlos; Mackey, Paul

2016-01-01

Historical data from the Apollo missions has compelled NASA to identify dust mitigation of spacesuits and other components as a critical path prior to sending humans on potential future lunar exploration missions. Several studies thus far have proposed passive and active countermeasures to address this challenge. However, these technologies have been primarily developed and proven for rigid surfaces such as solar cells and thermal radiators. Integration of these technologies for spacesuit dust mitigation has remained an open challenge due to the complexity of suit design. Current research investigates novel methods to enhance integration of the Electrodynamic Dust Shield (EDS) concept for spacesuits. We leverage previously proven EDS concept developed by NASA for rigid surfaces and apply new techniques to integrate the technology into spacesuits to mitigate dust contamination. The study specifically examines the feasibility of utilizing Carbon Nanotube (CNT) yarns manufactured by Rice University as electrodes in spacesuit material. Proof of concept testing was conducted at NASA Kennedy Space Center using lunar regolith simulant to understand the feasibility of the proposed techniques for spacesuit application. Results from the experiments are detailed in this paper. Potential challenges of applying this technology for spacesuits are also identified.

Screening for Barrett’s Esophagus and Esophageal Adenocarcinoma: Rationale, Recent Progress, Challenges and Future Directions

PubMed Central

Sami, Sarmed S.; Ragunath, Krish; Iyer, Prasad G.

2014-01-01

As the incidence and mortality of esophageal adenocarcinoma continue to increase, strategies to counter this need to be explored. Screening for Barrett’s esophagus, which is the known precursor of a large majority of adenocarcinomas, has been debated without a firm consensus. Given evidence for and against perceived benefits of screening, the multitude of challenges in the implementation of such a strategy and in the downstream management of subjects with Barrett’s esophagus who could be diagnosed by screening, support for screening has been modest. Recent advances in form of development and initial accuracy of non-invasive tools for screening, risk assessment tools and biomarker panels to risk stratify subjects with BE, have spurred renewed interest in the early detection of Barrett’s esophagus and related neoplasia, particularly with the advent of effective endoscopic therapy. In this review, we explore in depth, the potential rationale for screening for Barrett’s esophagus, recent advances which have the potential of making screening feasible and also highlight some of the challenges which will have to be overcome to develop an effective approach to improve the outcomes of subjects with esophageal adenocarcinoma. PMID:24887058

The promising future of microalgae: current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products.

PubMed

Khan, Muhammad Imran; Shin, Jin Hyuk; Kim, Jong Deog

2018-03-05

Microalgae have recently attracted considerable interest worldwide, due to their extensive application potential in the renewable energy, biopharmaceutical, and nutraceutical industries. Microalgae are renewable, sustainable, and economical sources of biofuels, bioactive medicinal products, and food ingredients. Several microalgae species have been investigated for their potential as value-added products with remarkable pharmacological and biological qualities. As biofuels, they are a perfect substitute to liquid fossil fuels with respect to cost, renewability, and environmental concerns. Microalgae have a significant ability to convert atmospheric CO 2 to useful products such as carbohydrates, lipids, and other bioactive metabolites. Although microalgae are feasible sources for bioenergy and biopharmaceuticals in general, some limitations and challenges remain, which must be overcome to upgrade the technology from pilot-phase to industrial level. The most challenging and crucial issues are enhancing microalgae growth rate and product synthesis, dewatering algae culture for biomass production, pretreating biomass, and optimizing the fermentation process in case of algal bioethanol production. The present review describes the advantages of microalgae for the production of biofuels and various bioactive compounds and discusses culturing parameters.

Evaluating the promise and pitfalls of a potential climate change-tolerant sea urchin fishery in southern California.

PubMed

Sato, Kirk N; Powell, Jackson; Rudie, Dave; Levin, Lisa A

2018-05-01

Marine fishery stakeholders are beginning to consider and implement adaptation strategies in the face of growing consumer demand and potential deleterious climate change impacts such as ocean warming, ocean acidification, and deoxygenation. This study investigates the potential for development of a novel climate change - tolerant sea urchin fishery in southern California based on Strongylocentrotus fragilis (pink sea urchin), a deep-sea species whose peak density was found to coincide with a current trap-based spot prawn fishery ( Pandalus platyceros ) in the 200-300-m depth range. Here we outline potential criteria for a climate change - tolerant fishery by examining the distribution, life-history attributes, and marketable qualities of S. fragilis in southern California. We provide evidence of seasonality of gonad production and demonstrate that peak gonad production occurs in the winter season. S. fragilis likely spawns in the spring season as evidenced by consistent minimum gonad indices in the spring/summer seasons across 4 years of sampling (2012-2016). The resiliency of S. fragilis to predicted future increases in acidity and decreases in oxygen was supported by high species abundance, albeit reduced relative growth rate estimates at water depths (485-510 m) subject to low oxygen (11.7-16.9 µmol kg -1 ) and pH Total (<7.44), which may provide assurances to stakeholders and managers regarding the suitability of this species for commercial exploitation. Some food quality properties of the S. fragilis roe (e.g. colour, texture) were comparable with those of the commercially exploited shallow-water red sea urchin ( Mesocentrotus franciscanus ), while other qualities (e.g. 80% reduced gonad size by weight) limit the potential future marketability of S. fragilis . This case study highlights the potential future challenges and drawbacks of climate-tolerant fishery development in an attempt to inform future urchin fishery stakeholders.

Future Supply Chains Enabled by Continuous Processing-Opportunities Challenges May 20-21 2014 Continuous Manufacturing Symposium.

PubMed

Srai, Jagjit Singh; Badman, Clive; Krumme, Markus; Futran, Mauricio; Johnston, Craig

2015-03-01

This paper examines the opportunities and challenges facing the pharmaceutical industry in moving to a primarily "continuous processing"-based supply chain. The current predominantly "large batch" and centralized manufacturing system designed for the "blockbuster" drug has driven a slow-paced, inventory heavy operating model that is increasingly regarded as inflexible and unsustainable. Indeed, new markets and the rapidly evolving technology landscape will drive more product variety, shorter product life-cycles, and smaller drug volumes, which will exacerbate an already unsustainable economic model. Future supply chains will be required to enhance affordability and availability for patients and healthcare providers alike despite the increased product complexity. In this more challenging supply scenario, we examine the potential for a more pull driven, near real-time demand-based supply chain, utilizing continuous processing where appropriate as a key element of a more "flow-through" operating model. In this discussion paper on future supply chain models underpinned by developments in the continuous manufacture of pharmaceuticals, we have set out; The paper recognizes that although current batch operational performance in pharma is far from optimal and not necessarily an appropriate end-state benchmark for batch technology, the adoption of continuous supply chain operating models underpinned by continuous production processing, as full or hybrid solutions in selected product supply chains, can support industry transformations to deliver right-first-time quality at substantially lower inventory profiles. © 2015 The Authors. Journal of Pharmaceutical Sciences published by Wiley Periodicals, Inc. and the American Pharmacists Association. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.

Identification of molecular and physiological responses to chronic environmental challenge in an invasive species: the Pacific oyster, Crassostrea gigas

PubMed Central

Clark, Melody S; Thorne, Michael A S; Amaral, Ana; Vieira, Florbela; Batista, Frederico M; Reis, João; Power, Deborah M

2013-01-01

Understanding the environmental responses of an invasive species is critical in predicting how ecosystem composition may be transformed in the future, especially under climate change. In this study, Crassostrea gigas, a species well adapted to the highly variable intertidal environment, was exposed to the chronic environmental challenges of temperature (19 and 24°C) and pH (ambient seawater and a reduction of 0.4 pH units) in an extended 3-month laboratory-based study. Physiological parameters were measured (condition index, shell growth, respiration, excretion rates, O:N ratios, and ability to repair shell damage) alongside molecular analyses. Temperature was by far the most important stressor, as demonstrated by reduced condition indexes and shell growth at 24°C, with relatively little effect detected for pH. Transcriptional profiling using candidate genes and SOLiD sequencing of mantle tissue revealed that classical “stress” genes, previously reported to be upregulated under acute temperature challenges, were not significantly expressed in any of the treatments, emphasizing the different response between acute and longer term chronic stress. The transcriptional profiling also elaborated on the cellular responses underpinning the physiological results, including the identification of the PI3K/AKT/mTOR pathway as a potentially novel marker for chronic environmental challenge. This study represents a first attempt to understand the energetic consequences of cumulative thermal stress on the intertidal C. gigas which could significantly impact on coastal ecosystem biodiversity and function in the future. PMID:24223268

The legacy of chlorinated solvents in the Birmingham aquifer, UK: Observations spanning three decades and the challenge of future urban groundwater development

NASA Astrophysics Data System (ADS)

Rivett, Michael O.; Turner, Ryan J.; Glibbery (née Murcott), Penny; Cuthbert, Mark O.

2012-10-01

Licensed abstraction well data collected during 1986-2008 from a total of 77 wells mainly located at industrial sites combined with historic land use data from 1975 has allowed insight into the legacy of chlorinated solvent contamination in the Birmingham aquifer that underlies the UK's second largest city. This legacy, expected to be reasonably symptomatic of those occurring in other urban aquifers, was characterised by: dominance of parent solvents, particularly TCE (trichloroethene) that widely exceeded drinking-water quality criteria; greater TCE occurrence in wells in proximity to increased historic land use by the metal/engineering solvent-user industry (the relationship providing a first-pass indicator of future resource development potential); regional groundwater vulnerability controls; well abstraction changes (over months to decades) influential of observed concentration transients and anticipated plume capture or release; persistence of contamination over decades (with less soluble PCE (perchloroethene) showing increased persistence relative to TCE) that was reasonably ascribed to slow contaminant release from DNAPL (dense non-aqueous phase liquid) sources and, or low permeability layers; presence of dechlorination products arising from solvent (bio)degradation, although this key attenuation process appeared to have moderate to weak influence regionally on plumes; and, inadvertent, but significant solvent mass removal from the aquifer by industrial abstractions. Key challenges to realising future urban groundwater development were identified based on the observed legacy and well capture zone simulations. Despite the extensive contamination of the aquifer, it should still be possible to develop wells of high (several megalitres per day) capacity for drinking water supply (or other lower grade uses) without the requirement for solvent treatment. In those areas with higher risk of contamination, our dataset, together with application of emergent risk assessment approaches (that our dataset may serve to validate), could be used to inform potential abstractors as to whether solvent treatment is likely to be required at a particular abstraction site with time. Challenges identified that were relevant to the future development of Birmingham and urban aquifers more generally include the adequacy of groundwater quality monitoring data and uncertainties in contaminant source terms, abstraction well capture zone predictions and plume natural attenuation, in particular degradation rates. The study endorses that despite significant solvent contamination encountered, strategies can, and need, to be increasingly found to reclaim urban aquifer resources and more sustainably meet urban water demands.

Artificial Intelligence for the Artificial Kidney: Pointers to the Future of a Personalized Hemodialysis Therapy.

PubMed

Hueso, Miguel; Vellido, Alfredo; Montero, Nuria; Barbieri, Carlo; Ramos, Rosa; Angoso, Manuel; Cruzado, Josep Maria; Jonsson, Anders

2018-02-01

Current dialysis devices are not able to react when unexpected changes occur during dialysis treatment or to learn about experience for therapy personalization. Furthermore, great efforts are dedicated to develop miniaturized artificial kidneys to achieve a continuous and personalized dialysis therapy, in order to improve the patient's quality of life. These innovative dialysis devices will require a real-time monitoring of equipment alarms, dialysis parameters, and patient-related data to ensure patient safety and to allow instantaneous changes of the dialysis prescription for the assessment of their adequacy. The analysis and evaluation of the resulting large-scale data sets enters the realm of "big data" and will require real-time predictive models. These may come from the fields of machine learning and computational intelligence, both included in artificial intelligence, a branch of engineering involved with the creation of devices that simulate intelligent behavior. The incorporation of artificial intelligence should provide a fully new approach to data analysis, enabling future advances in personalized dialysis therapies. With the purpose to learn about the present and potential future impact on medicine from experts in artificial intelligence and machine learning, a scientific meeting was organized in the Hospital Universitari Bellvitge (L'Hospitalet, Barcelona). As an outcome of that meeting, the aim of this review is to investigate artificial intel ligence experiences on dialysis, with a focus on potential barriers, challenges, and prospects for future applications of these technologies. Artificial intelligence research on dialysis is still in an early stage, and the main challenge relies on interpretability and/or comprehensibility of data models when applied to decision making. Artificial neural networks and medical decision support systems have been used to make predictions about anemia, total body water, or intradialysis hypotension and are promising approaches for the prescription and monitoring of hemodialysis therapy. Current dialysis machines are continuously improving due to innovative technological developments, but patient safety is still a key challenge. Real-time monitoring systems, coupled with automatic instantaneous biofeedback, will allow changing dialysis prescriptions continuously. The integration of vital sign monitoring with dialysis parameters will produce large data sets that will require the use of data analysis techniques, possibly from the area of machine learning, in order to make better decisions and increase the safety of patients.

Surrogate Joint Aerial Layer Network (JALN) Experiment: Applications of Commercial-Off-The-Shelf Technologies for Researching Future JALN Challenges

DTIC Science & Technology

2014-12-01

CHALLENGES DECEMBER 2014 TECHNICAL REPORT APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED STINFO COPY AIR FORCE RESEARCH LABORATORY INFORMATION...JOINT AERIAL LAYER NETWORK (JALN) EXPERIMENT: APPLICATION OF COMMERCIAL-OFF-THE-SHELF TECHNOLOGIES FOR RESEARCHING FUTURE JALN CHALLENGES 5a... challenge JALN developers. The use of low-cost COTS wireless technology is found to be a suitable surrogate for military hardware for investigating

Sensitivity of climate mitigation strategies to natural disturbances

DOE Office of Scientific and Technical Information (OSTI.GOV)

Le Page, Yannick LB; Hurtt, George; Thomson, Allison M.

2013-02-19

The present and future concentration of atmospheric carbon dioxide depends on both anthropogenic and natural sources and sinks of carbon. Most proposed climate mitigation strategies rely on a progressive transition to carbon12 efficient technologies to reduce industrial emissions, substantially supported by policies to maintain or enhance the terrestrial carbon stock in forests and other ecosystems. This strategy may be challenged if terrestrial sequestration capacity is affected by future climate feedbacks, but how and to what extent is little understood. Here, we show that climate mitigation strategies are highly sensitive to future natural disturbance rates (e.g. fires, hurricanes, droughts), because ofmore » potential effect of disturbances on the terrestrial carbon balance. Generally, altered disturbance rates affect the pace of societal and technological transitions required to achieve the mitigation target, with substantial consequences on the energy sector and on the global economy. Understanding the future dynamics and consequences of natural disturbances on terrestrial carbon balance is thus essential for developing robust climate mitigation strategies and policies« less

Grade-Level Differences in Future-Oriented Self-Concept During Early Adolescence: Potential Relevance to School Nursing

PubMed Central

2016-01-01

The middle school and early high school years are a time of significant development, including an increasing ability to envision oneself in the future. Little is known about how adolescents’ future-oriented self-concept (i.e., possible selves) differs across grade levels, although this knowledge may aid in establishing rapport with students and building effective health-promotion and risk reduction interventions. Therefore, this study explored grade-level differences in hoped for and feared possible selves in a sample of 6th – 9th grade students (n = 2,498; Mage = 12.72, SD = 1.15; 51.3% female). Findings suggest that adolescents list a variety of possible selves, and the content differs according to grade-level. These findings offer helpful insight for intervention work aimed at improving student outcomes and preventing risk behavior. Understanding what adolescents hope and fear for themselves in the future may be particularly beneficial for school nurses in identifying the unique challenges students experience and tailoring health-promotion efforts. PMID:27222444

Sustainable water management under future uncertainty with eco-engineering decision scaling

NASA Astrophysics Data System (ADS)

Poff, N. Leroy; Brown, Casey M.; Grantham, Theodore E.; Matthews, John H.; Palmer, Margaret A.; Spence, Caitlin M.; Wilby, Robert L.; Haasnoot, Marjolijn; Mendoza, Guillermo F.; Dominique, Kathleen C.; Baeza, Andres

2016-01-01

Managing freshwater resources sustainably under future climatic and hydrological uncertainty poses novel challenges. Rehabilitation of ageing infrastructure and construction of new dams are widely viewed as solutions to diminish climate risk, but attaining the broad goal of freshwater sustainability will require expansion of the prevailing water resources management paradigm beyond narrow economic criteria to include socially valued ecosystem functions and services. We introduce a new decision framework, eco-engineering decision scaling (EEDS), that explicitly and quantitatively explores trade-offs in stakeholder-defined engineering and ecological performance metrics across a range of possible management actions under unknown future hydrological and climate states. We illustrate its potential application through a hypothetical case study of the Iowa River, USA. EEDS holds promise as a powerful framework for operationalizing freshwater sustainability under future hydrological uncertainty by fostering collaboration across historically conflicting perspectives of water resource engineering and river conservation ecology to design and operate water infrastructure for social and environmental benefits.

Grade-Level Differences in Future-Oriented Self-Concept During Early Adolescence: Potential Relevance to School Nursing.

PubMed

Stoddard, Sarah A; Pierce, Jennifer; Schmidt, Carissa J

2016-12-01

The middle school and early high school years are a time of significant development, including an increasing ability to envision oneself in the future. Little is known about how adolescents' future-oriented self-concept (i.e., possible selves) differs across grade levels, although this knowledge may aid in establishing rapport with students and building effective health promotion and risk reduction interventions. Therefore, this study explored grade-level differences in hoped for and feared possible selves in a sample of sixth- to ninth-grade students (n = 2,498; M age = 12.72, SD = 1.15; 51.3% female). Findings suggest that adolescents list a variety of possible selves, and the content differs according to grade level. These findings offer helpful insight for intervention work aimed at improving student outcomes and preventing risk behavior. Understanding what adolescents hope and fear for themselves in the future may be particularly beneficial for school nurses in identifying the unique challenges students experience and tailoring health promotion efforts. © The Author(s) 2016.

Sustainable water management under future uncertainty with eco-engineering decision scaling

USGS Publications Warehouse

Poff, N LeRoy; Brown, Casey M; Grantham, Theodore E.; Matthews, John H; Palmer, Margaret A.; Spence, Caitlin M; Wilby, Robert L.; Haasnoot, Marjolijn; Mendoza, Guillermo F; Dominique, Kathleen C; Baeza, Andres

2015-01-01

Managing freshwater resources sustainably under future climatic and hydrological uncertainty poses novel challenges. Rehabilitation of ageing infrastructure and construction of new dams are widely viewed as solutions to diminish climate risk, but attaining the broad goal of freshwater sustainability will require expansion of the prevailing water resources management paradigm beyond narrow economic criteria to include socially valued ecosystem functions and services. We introduce a new decision framework, eco-engineering decision scaling (EEDS), that explicitly and quantitatively explores trade-offs in stakeholder-defined engineering and ecological performance metrics across a range of possible management actions under unknown future hydrological and climate states. We illustrate its potential application through a hypothetical case study of the Iowa River, USA. EEDS holds promise as a powerful framework for operationalizing freshwater sustainability under future hydrological uncertainty by fostering collaboration across historically conflicting perspectives of water resource engineering and river conservation ecology to design and operate water infrastructure for social and environmental benefits.

Information from the Internet and the doctor-patient relationship: the patient perspective – a qualitative study

PubMed Central

Stevenson, Fiona A; Kerr, Cicely; Murray, Elizabeth; Nazareth, Irwin

2007-01-01

Background Both doctors and patients may perceive the Internet as a potential challenge to existing therapeutic relationships. Here we examine patients' views of the effect of the Internet on their relationship with doctors. Methods We ran 8 disease specific focus groups of between 2 and 8 respondents comprising adult patients with diabetes mellitus, ischaemic heart disease or hepatitis C. Results Data are presented on (i) the perceived benefits and (ii) limitations of the Internet in the context of the doctor-patient relationship, (iii) views on sharing information with doctors, and (iv) the potential of the Internet for the future. Information from the Internet was particularly valued in relation to experiential knowledge. Conclusion Despite evidence of increasing patient activism in seeking information and the potential to challenge the position of the doctor, the accounts here do not in any way suggest a desire to disrupt the existing balance of power, or roles, in the consultation. Patients appear to see the Internet as an additional resource to support existing and valued relationships with their doctors. Doctors therefore need not feel challenged or threatened when patients bring health information from the Internet to a consultation, rather they should see it as an attempt on the part of the patient to work with the doctor and respond positively. PMID:17705836

Reference Structures: Stagnation, Progress, and Future Challenges.

ERIC Educational Resources Information Center

Greenberg, Jane

1997-01-01

Assesses the current state of reference structures in online public access catalogs (OPACs) in a framework defined by stagnation, progress, and future challenges. Outlines six areas for reference structure development. Twenty figures provide illustrations. (AEF)

Roadmap on neurophotonics

NASA Astrophysics Data System (ADS)

Cho, Yong Ku; Zheng, Guoan; Augustine, George J.; Hochbaum, Daniel; Cohen, Adam; Knöpfel, Thomas; Pisanello, Ferruccio; Pavone, Francesco S.; Vellekoop, Ivo M.; Booth, Martin J.; Hu, Song; Zhu, Jiang; Chen, Zhongping; Hoshi, Yoko

2016-09-01

Mechanistic understanding of how the brain gives rise to complex behavioral and cognitive functions is one of science’s grand challenges. The technical challenges that we face as we attempt to gain a systems-level understanding of the brain are manifold. The brain’s structural complexity requires us to push the limit of imaging resolution and depth, while being able to cover large areas, resulting in enormous data acquisition and processing needs. Furthermore, it is necessary to detect functional activities and ‘map’ them onto the structural features. The functional activity occurs at multiple levels, using electrical and chemical signals. Certain electrical signals are only decipherable with sub-millisecond timescale resolution, while other modes of signals occur in minutes to hours. For these reasons, there is a wide consensus that new tools are necessary to undertake this daunting task. Optical techniques, due to their versatile and scalable nature, have great potentials to answer these challenges. Optical microscopy can now image beyond the diffraction limit, record multiple types of brain activity, and trace structural features across large areas of tissue. Genetically encoded molecular tools opened doors to controlling and detecting neural activity using light in specific cell types within the intact brain. Novel sample preparation methods that reduce light scattering have been developed, allowing whole brain imaging in rodent models. Adaptive optical methods have the potential to resolve images from deep brain regions. In this roadmap article, we showcase a few major advances in this area, survey the current challenges, and identify potential future needs that may be used as a guideline for the next steps to be taken.

Characterization of the Burkholderia mallei tonB Mutant and Its Potential as a Backbone Strain for Vaccine Development

PubMed Central

Mott, Tiffany M.; Vijayakumar, Sudhamathi; Sbrana, Elena; Endsley, Janice J.; Torres, Alfredo G.

2015-01-01

Background In this study, a Burkholderia mallei tonB mutant (TMM001) deficient in iron acquisition was constructed, characterized, and evaluated for its protective properties in acute inhalational infection models of murine glanders and melioidosis. Methodology/Principal Findings Compared to the wild-type, TMM001 exhibits slower growth kinetics, siderophore hyper-secretion and the inability to utilize heme-containing proteins as iron sources. A series of animal challenge studies showed an inverse correlation between the percentage of survival in BALB/c mice and iron-dependent TMM001 growth. Upon evaluation of TMM001 as a potential protective strain against infection, we found 100% survival following B. mallei CSM001 challenge of mice previously receiving 1.5 x 104 CFU of TMM001. At 21 days post-immunization, TMM001-treated animals showed significantly higher levels of B. mallei-specific IgG1, IgG2a and IgM when compared to PBS-treated controls. At 48 h post-challenge, PBS-treated controls exhibited higher levels of serum inflammatory cytokines and more severe pathological damage to target organs compared to animals receiving TMM001. In a cross-protection study of acute inhalational melioidosis with B. pseudomallei, TMM001-treated mice were significantly protected. While wild type was cleared in all B. mallei challenge studies, mice failed to clear TMM001. Conclusions/Significance Although further work is needed to prevent chronic infection by TMM001 while maintaining immunogenicity, our attenuated strain demonstrates great potential as a backbone strain for future vaccine development against both glanders and melioidosis. PMID:26114445

Characterization of the Burkholderia mallei tonB Mutant and Its Potential as a Backbone Strain for Vaccine Development.

PubMed

Mott, Tiffany M; Vijayakumar, Sudhamathi; Sbrana, Elena; Endsley, Janice J; Torres, Alfredo G

2015-01-01

In this study, a Burkholderia mallei tonB mutant (TMM001) deficient in iron acquisition was constructed, characterized, and evaluated for its protective properties in acute inhalational infection models of murine glanders and melioidosis. Compared to the wild-type, TMM001 exhibits slower growth kinetics, siderophore hyper-secretion and the inability to utilize heme-containing proteins as iron sources. A series of animal challenge studies showed an inverse correlation between the percentage of survival in BALB/c mice and iron-dependent TMM001 growth. Upon evaluation of TMM001 as a potential protective strain against infection, we found 100% survival following B. mallei CSM001 challenge of mice previously receiving 1.5 x 10(4) CFU of TMM001. At 21 days post-immunization, TMM001-treated animals showed significantly higher levels of B. mallei-specific IgG1, IgG2a and IgM when compared to PBS-treated controls. At 48 h post-challenge, PBS-treated controls exhibited higher levels of serum inflammatory cytokines and more severe pathological damage to target organs compared to animals receiving TMM001. In a cross-protection study of acute inhalational melioidosis with B. pseudomallei, TMM001-treated mice were significantly protected. While wild type was cleared in all B. mallei challenge studies, mice failed to clear TMM001. Although further work is needed to prevent chronic infection by TMM001 while maintaining immunogenicity, our attenuated strain demonstrates great potential as a backbone strain for future vaccine development against both glanders and melioidosis.

Contact lens wearers' experiences while trekking in the Khumbu region/Nepal: a cross-sectional survey.

PubMed

Bauer, Irmgard L

2015-01-01

Safe contact lens wear depends on a hygiene regime and lens-appropriate wear patterns which may be compromised during travel in remote and wilderness areas. The purpose of this study was to describe the experience of contact lens wearers while trekking at high-altitude in Nepal. For this descriptive study, trekkers with contact lenses were recruited in Lukla and invited to complete an online-questionnaire on trip preparation, contact lens use, care and experiences, and possible changes for future travel. Quantitative data were analysed using SurveyMonkey; content analysis applied to qualitative responses. The majority of the 158 participants (124; 78.48%) reported no problems with their lenses (daily disposables, soft lenses, extended-wear lenses, hard/rigid lenses) during their stay although dry air, dust, wind, cold temperatures, and difficult hygiene maintenance were challenging. Freezing lenses and freezing solutions were additional challenges. Thirty-four (21.52%) experienced a variety of problems. Improvements were requested from manufacturers. Lodges should provide better access to clean water, mirrors and lighting. Almost 60% of participants had not sought any pre-travel health advice. Remote and wilderness areas provide a challenge for appropriate contact lens wear and care. The decision between the potential risk of infection due to touching lenses (daily disposables, soft/hard lenses) and the potential risk of corneal erosion (extended-wear lenses) needs to be made in pre-travel consultations. Travel health professionals and travel agencies should remind CL-wearing trekkers to carefully assess their wear and care routine to accommodate potentially challenging conditions. Copyright © 2015 Elsevier Ltd. All rights reserved.

Roadmap on neurophotonics

PubMed Central

Cho, Yong Ku; Zheng, Guoan; Augustine, George J; Hochbaum, Daniel; Cohen, Adam; Knöpfel, Thomas; Pisanello, Ferruccio; Pavone, Francesco S; Vellekoop, Ivo M; Booth, Martin J; Hu, Song; Zhu, Jiang; Chen, Zhongping; Hoshi, Yoko

2017-01-01

Mechanistic understanding of how the brain gives rise to complex behavioral and cognitive functions is one of science’s grand challenges. The technical challenges that we face as we attempt to gain a systems-level understanding of the brain are manifold. The brain’s structural complexity requires us to push the limit of imaging resolution and depth, while being able to cover large areas, resulting in enormous data acquisition and processing needs. Furthermore, it is necessary to detect functional activities and ‘map’ them onto the structural features. The functional activity occurs at multiple levels, using electrical and chemical signals. Certain electrical signals are only decipherable with sub-millisecond timescale resolution, while other modes of signals occur in minutes to hours. For these reasons, there is a wide consensus that new tools are necessary to undertake this daunting task. Optical techniques, due to their versatile and scalable nature, have great potentials to answer these challenges. Optical microscopy can now image beyond the diffraction limit, record multiple types of brain activity, and trace structural features across large areas of tissue. Genetically encoded molecular tools opened doors to controlling and detecting neural activity using light in specific cell types within the intact brain. Novel sample preparation methods that reduce light scattering have been developed, allowing whole brain imaging in rodent models. Adaptive optical methods have the potential to resolve images from deep brain regions. In this roadmap article, we showcase a few major advances in this area, survey the current challenges, and identify potential future needs that may be used as a guideline for the next steps to be taken. PMID:28386392

Energy Requirements by the Water Sector in the Southwestern US: Past, Present, and Future

NASA Astrophysics Data System (ADS)

Averyt, K.; Yates, D. N.; Meldrum, J.

2014-12-01

Climate, energy, and water are fundamentally linked such that shifts in one sector have cascading impacts on the others. Consideration of the integrated system is necessary to fully understand the individual risk profile of each sector. In defining vulnerabilities and potential adaptations, the policy and regulatory environment must be considered alongside the biological and physical systems. Take, for example, the Southwestern U.S., a naturally arid system, where water availability is declining as a consequence of climate change and population growth. Adaptations by the water sector to convey, store, and develop new water sources (e.g. desalination, groundwater pumping, water-reuse) are strategies designed to enhance sustainability of the sector. But, the energy requirements embedded in these management techniques pose challenges to electric utilities. West wide, approximately 20% of total electricity generation goes toward supplying and heating water. If future investments made by the water sector to deal with changing supply and demand regimes continue to follow current trends, the dependence of water on energy availability will grow, meaning that the water supply will be increasingly reliant on the electricity system. Here, we use the example of long-term aridity and the recent drought in the Western US to illustrate the tradeoffs and challenges inherent at the nexus between energy and water. We present long-term trends in the energy intensity of water supplies in the Southwestern US, with a specific focus on groundwater systems. Projected energy requirements for proposed and future conveyance systems are discussed. The potential impacts of reduced flows on the Colorado River on the energy demands for groundwater pumping in the Lower Colorado River Basin are highlighted.

Futures research: A neglected dimension in environmental policy and planning

Treesearch

David N. Bengston

2012-01-01

The need for strategic foresight in an increasingly complex and rapidly changing world poses a formidable challenge to environmental planners and policy makers. Th is paper introduces futures research as an under used but fruitful set of approaches to addressing this challenge. Futures research is a transdisciplinary social science that uses a wide range of methods to...

The food production and consumption balance in sub-Saharan Africa under different SSPs, from 2010 to 2050

NASA Astrophysics Data System (ADS)

Wada, Y.; Luan, Y.; Fischer, G.; Sun, L.; Shi, P.

2015-12-01

Forcing with the population growth and consequently increasing food requirement, food security in sub-Saharan Africa is one of the most emergent and challenging issues. The purposes of this work are 1) what's the future food requirement and their food security status in each sub-Saharan African countries? What is the distance from current and future food security status, corresponding to the food requirement, to the targeted food security status? 2) To what extent Sub-Saharan countries could meet their present and future food requirement, and whether they have potential to improve their food insecurity status on currently cultivated land? 3) Whether or, if there have, how the pressures on land resources from meeting the food requirements? To figure those questions out, we firstly use socio-economic pathways datasets, and historical food diet pattern classification to forecast the 2010-2050 food commodity and feed calories demand per country. A new food security indicator, which considered the influences of both the food energy and quality intake, was used to evaluate the food insecurity status and the distances to different targeted statuses of the specific country. The latest Global Agro-Ecological Zones (GAEZ) databases were used to estimate the current and future crop yield gap and crop potential production. For current to future scenario analysis, we considered population growth, dietary change, climate change, agricultural input level, and target food security status. Then the balance of food requirement with the current and potential crop production was analyzed for different scenarios. Land requirements were calculated for meeting those food requirements, and the pressures on land resources are evaluated. Our works are hoping to provide scientific-based evidences for policy recommendations for local government to tackle food insecurity problems in Sub-Saharan Africa.

Targeted delivery of miRNA therapeutics for cardiovascular diseases: opportunities and challenges.

PubMed

Kwekkeboom, Rick F J; Lei, Zhiyong; Doevendans, Pieter A; Musters, René J P; Sluijter, Joost P G

2014-09-01

Dysregulation of miRNA expression has been associated with many cardiovascular diseases in animal models, as well as in patients. In the present review, we summarize recent findings on the role of miRNAs in cardiovascular diseases and discuss the opportunities, possibilities and challenges of using miRNAs as future therapeutic targets. Furthermore, we focus on the different approaches that can be used to deliver these newly developed miRNA therapeutics to their sites of action. Since siRNAs are structurally homologous with the miRNA therapeutics, important lessons learned from siRNA delivery strategies are discussed that might be applicable to targeted delivery of miRNA therapeutics, thereby reducing costs and potential side effects, and improving efficacy.

Concept Design of High Power Solar Electric Propulsion Vehicles for Human Exploration

NASA Technical Reports Server (NTRS)

Hoffman, David J.; Kerslake, Thomas W.; Hojnicki, Jeffrey S.; Manzella, David H.; Falck, Robert D.; Cikanek, Harry A., III; Klem, Mark D.; Free, James M.

2011-01-01

Human exploration beyond low Earth orbit will require enabling capabilities that are efficient, affordable and reliable. Solar electric propulsion (SEP) has been proposed by NASA s Human Exploration Framework Team as one option to achieve human exploration missions beyond Earth orbit because of its favorable mass efficiency compared to traditional chemical propulsion systems. This paper describes the unique challenges associated with developing a large-scale high-power (300-kWe class) SEP vehicle and design concepts that have potential to meet those challenges. An assessment of factors at the subsystem level that must be considered in developing an SEP vehicle for future exploration missions is presented. Overall concepts, design tradeoffs and pathways to achieve development readiness are discussed.

The challenge of gun control for mental health advocates.

PubMed

Pandya, Anand

2013-09-01

Mass shootings, such as the 2012 Newtown massacre, have repeatedly led to political discourse about limiting access to guns for individuals with serious mental illness. Although the political climate after such tragic events poses a considerable challenge to mental health advocates who wish to minimize unsympathetic portrayals of those with mental illness, such media attention may be a rare opportunity to focus attention on risks of victimization of those with serious mental illness and barriers to obtaining psychiatric care. Current federal gun control laws may discourage individuals from seeking psychiatric treatment and describe individuals with mental illness using anachronistic, imprecise, and gratuitously stigmatizing language. This article lays out potential talking points that may be useful after future gun violence.

Procedural Challenges In International Collaborative Research

PubMed Central

Loo, Kek Khee

2009-01-01

There is tremendous promise for a rewarding experience in an international research project due to the collaboration, mutual learning and cultural bridging that intrinsically occur. However, knowledge of the procedural requirements for international research is not widely disseminated to investigators who may not have been involved in the administration of a federal grant with a foreign component. The purpose of this article is to highlight the major challenges in administrative, procedural and equipment management aspects of grant implementation when federal funding is involved in international collaborative research. It is hoped that awareness of these difficulties and demystification of the process for future investigators can minimize the potential encumbrances in a rewarding journey towards realizing the scientific goals in an international collaborative research project. PMID:19574522

Outlook and Challenges of Perovskite Solar Cells toward Terawatt-Scale Photovoltaic Module Technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhu, Kai; Kim, Donghoe; Whitaker, James B

Rapid development of perovskite solar cells (PSCs) during the past several years has made this photovoltaic (PV) technology a serious contender for potential large-scale deployment on the terawatt scale in the PV market. To successfully transition PSC technology from the laboratory to industry scale, substantial efforts need to focus on scalable fabrication of high-performance perovskite modules with minimum negative environmental impact. Here, we provide an overview of the current research and our perspective regarding PSC technology toward future large-scale manufacturing and deployment. Several key challenges discussed are (1) a scalable process for large-area perovskite module fabrication; (2) less hazardous chemicalmore » routes for PSC fabrication; and (3) suitable perovskite module designs for different applications.« less

Fire and reduced vigor facilitate vegetation shifts: MC2 results for the conterminous US with CMIP5 climate futures

NASA Astrophysics Data System (ADS)

Bachelet, D. M.; Ferschweiler, K.; Baker, B.; Sleeter, B. M.

2016-12-01

Climate variability and a warming trend during the 21st century ensures fuel build-up and episodic catastrophic wildfires. We used downscaled (2.5 arcmin) CMIP5 climate futures from 20 models under RCP 8.5 to run the dynamic global vegetation model MC2 over the conterminous US and identify key drivers of land cover change. We show regional and temporal differences in the magnitude of projected C losses due to fire over the 21st century. We also look at the vigor (NPP/LAI) of forest lands and estimate the loss in C capture due to declines in production as well as the increase in heterotrophic respiration due to increased mortality. We compare simulated the carbon sequestration potential of terrestrial biomes and the risk of carbon losses through disturbance. We quantify uncertainty in model results by showing the distribution of possible future impacts under 20 futures. We explore the effects of land use and highlight the challenges we met to simulate credible transient management practices throughout the 20th century and into the future.

A bottom-up robust optimization framework for identifying river basin development pathways under deep climate uncertainty

NASA Astrophysics Data System (ADS)

Taner, M. U.; Ray, P.; Brown, C.

2016-12-01

Hydroclimatic nonstationarity due to climate change poses challenges for long-term water infrastructure planning in river basin systems. While designing strategies that are flexible or adaptive hold intuitive appeal, development of well-performing strategies requires rigorous quantitative analysis that address uncertainties directly while making the best use of scientific information on the expected evolution of future climate. Multi-stage robust optimization (RO) offers a potentially effective and efficient technique for addressing the problem of staged basin-level planning under climate change, however the necessity of assigning probabilities to future climate states or scenarios is an obstacle to implementation, given that methods to reliably assign probabilities to future climate states are not well developed. We present a method that overcomes this challenge by creating a bottom-up RO-based framework that decreases the dependency on probability distributions of future climate and rather employs them after optimization to aid selection amongst competing alternatives. The iterative process yields a vector of `optimal' decision pathways each under the associated set of probabilistic assumptions. In the final phase, the vector of optimal decision pathways is evaluated to identify the solutions that are least sensitive to the scenario probabilities and are most-likely conditional on the climate information. The framework is illustrated for the planning of new dam and hydro-agricultural expansions projects in the Niger River Basin over a 45-year planning period from 2015 to 2060.

Potential of insulin nanoparticle formulations for oral delivery and diabetes treatment.

PubMed

Wong, Chun Y; Al-Salami, Hani; Dass, Crispin R

2017-10-28

Nanoparticles have demonstrated significant advancements in potential oral delivery of insulin. In this publication, we review the current status of polymeric, inorganic and solid-lipid nanoparticles designed for oral administration of insulin. Firstly, the structure and physiological function of insulin are examined. Then, the efficiency and shortcomings of insulin nanoparticle are discussed. These include the susceptibility to digestive enzyme degradation, instability in the acidic pH environment, poor mucus diffusion and inadequate permeation through the gastrointestinal epithelium. In order to optimise the nanocarriers, the following considerations, including polymer nature, surface charge, size, polydispersity index and morphology of nanoparticles, have to be taken into account. Some novel designs such as chitosan-based glucose-responsive nanoparticles, layer by layer technique-based nanoparticles and zwitterion nanoparticles are being adopted to overcome the physiological challenges. The review ends with some future directions and challenges to be addressed for the success of oral delivery of insulin-loaded nanoparticle formulation. Copyright © 2017 Elsevier B.V. All rights reserved.

The role of muscle synergies in myoelectric control: trends and challenges for simultaneous multifunction control

NASA Astrophysics Data System (ADS)

Ison, Mark; Artemiadis, Panagiotis

2014-10-01

Myoelectric control is filled with potential to significantly change human-robot interaction due to the ability to non-invasively measure human motion intent. However, current control schemes have struggled to achieve the robust performance that is necessary for use in commercial applications. As demands in myoelectric control trend toward simultaneous multifunctional control, multi-muscle coordinations, or synergies, play larger roles in the success of the control scheme. Detecting and refining patterns in muscle activations robust to the high variance and transient changes associated with surface electromyography is essential for efficient, user-friendly control. This article reviews the role of muscle synergies in myoelectric control schemes by dissecting each component of the scheme with respect to associated challenges for achieving robust simultaneous control of myoelectric interfaces. Electromyography recording details, signal feature extraction, pattern recognition and motor learning based control schemes are considered, and future directions are proposed as steps toward fulfilling the potential of myoelectric control in clinically and commercially viable applications.

Big Effect of Small Nanoparticles: A Shift in Paradigm for Polymer Nanocomposites

DOE PAGES

Cheng, Shiwang; Xie, Shi-Jie; Carrillo, Jan-Michael Y.; ...

2017-01-04

Polymer nanocomposites (PNCs) are important materials that are widely used in many current technologies and potentially have broader applications in the future due to their excellent property of tunability, light weight and low cost. But, expanding the limits in property enhancement remains a fundamental scientific challenge. We demonstrate that well-dispersed, small (diameter ~1.8 nm) nanoparticles with attractive interactions lead to unexpectedly large and qualitatively new changes in PNC structural dynamics in comparison to conventional composites based on particles of diameter ~10-50 nm. At the same time, the zero-shear viscosity at high temperatures remains comparable to that of the neat polymer,more » thereby retaining good processibility and resolving a major challenge in PNC applications. These results suggest that the nanoparticle mobility and relatively short lifetimes of nanoparticlepolymer associations open qualitatively new horizons in tunability of macroscopic properties in nanocomposites with high potential for the development of new functional materials.« less

Recent developments with metalloprotease inhibitor class of drug candidates for Botulinum neurotoxins

DOE PAGES

Kumar, Gyanendra; Swaminathan, Subramanyam

2015-03-01

Botulinum Neurotoxins are the most poisonous of all toxins with lethal dose in nanogram quantities. They are also potential biological warfare and bioterrorism agents due to their high toxicity and ease of preparation. On the other hand BoNTs are also being increasingly used for therapeutic and cosmetic purposes, and with that the chances of accidental overdose are increasing. And despite the potential damage they could cause to human health, there are no post-intoxication drugs available so far. But progress is being made in this direction. The crystal structures in native form and bound with substrate peptides have been determined, andmore » these are enabling structure-based drug discovery possible. High throughput assays have also been designed to speed up the screening progress. Substrate-based and small molecule inhibitors have been identified. But turning high affinity inhibitors into clinically viable drug candidates has remained a challenge. We discuss here the latest developments and the future challenges in drug discovery for Botulinum neurotoxins.« less

Discovering the Neural Nature of Moral Cognition? Empirical, Theoretical, and Practical Challenges in Bioethical Research with Electroencephalography (EEG).

PubMed

Wagner, Nils-Frederic; Chaves, Pedro; Wolff, Annemarie

2017-06-01

In this article we critically review the neural mechanisms of moral cognition that have recently been studied via electroencephalography (EEG). Such studies promise to shed new light on traditional moral questions by helping us to understand how effective moral cognition is embodied in the brain. It has been argued that conflicting normative ethical theories require different cognitive features and can, accordingly, in a broadly conceived naturalistic attempt, be associated with different brain processes that are rooted in different brain networks and regions. This potentially morally relevant brain activity has been empirically investigated through EEG-based studies on moral cognition. From neuroscientific evidence gathered in these studies, a variety of normative conclusions have been drawn and bioethical applications have been suggested. We discuss methodological and theoretical merits and demerits of the attempt to use EEG techniques in a morally significant way, point to legal challenges and policy implications, indicate the potential to reveal biomarkers of psychopathological conditions, and consider issues that might inform future bioethical work.

Impact of HIPAA on Subject Recruitment and Retention

PubMed Central

Wipke-Tevis, Deidre D.; Pickett, Melissa A.

2009-01-01

Recruiting and retaining an adequate sample of subjects is critical to the success of any research project involving human subjects. Recent reports indicate the Health Insurance Portability and Accountability Act (HIPAA) Privacy rule has adversely impacted research. Few resources are available to help researchers and their staff navigate the challenges to subject recruitment and retention after the implementation of the HIPAA Privacy rule. This article will address obstacles to subject recruitment in prospective, clinical research studies related specifically to the HIPAA Privacy rule as well as HIPAA compliant strategies to enhance subject recruitment and retention. Recruitment challenges discussed include evolving interpretations of the HIPAA regulations, inability to directly contact potential subjects, complexity of the HIPAA required documents, the increased cost of subject recruitment, and an expanding administrative burden. Among the strategies addressed are preparatory research reviews, use of clinical collaborators/staff liaisons, pre-screening of potential subjects, minimizing subject burden during the consent process, enhancing follow-up of subjects, facilitating recruitment for future studies and streamlining compliance training for research staff. PMID:17551087

Millimetre-Wave Backhaul for 5G Networks: Challenges and Solutions

PubMed Central

Feng, Wei; Li, Yong; Jin, Depeng; Su, Li; Chen, Sheng

2016-01-01

The trend for dense deployment in future 5G mobile communication networks makes current wired backhaul infeasible owing to the high cost. Millimetre-wave (mm-wave) communication, a promising technique with the capability of providing a multi-gigabit transmission rate, offers a flexible and cost-effective candidate for 5G backhauling. By exploiting highly directional antennas, it becomes practical to cope with explosive traffic demands and to deal with interference problems. Several advancements in physical layer technology, such as hybrid beamforming and full duplexing, bring new challenges and opportunities for mm-wave backhaul. This article introduces a design framework for 5G mm-wave backhaul, including routing, spatial reuse scheduling and physical layer techniques. The associated optimization model, open problems and potential solutions are discussed to fully exploit the throughput gain of the backhaul network. Extensive simulations are conducted to verify the potential benefits of the proposed method for the 5G mm-wave backhaul design. PMID:27322265

Recent developments with metalloprotease inhibitor class of drug candidates for botulinum neurotoxins.

PubMed

Kumar, Gyanendra; Swaminathan, Subramanyam

2015-01-01

Botulinum Neurotoxins are the most poisonous of all toxins with lethal dose in nanogram quantities. They are potential biological warfare and bioterrorism agents due to their high toxicity and ease of preparation. On the other hand BoNTs are also being increasingly used for therapeutic and cosmetic purposes, and with that the chances of accidental overdose are increasing. And despite the potential damage they could cause to human health, there are no post-intoxication drugs available so far. But progress is being made in this direction. The crystal structures in native form and bound with substrate peptides have been determined, and these are enabling structure-based drug discovery possible. High throughput assays have also been designed to speed up the screening progress. Substrate-based and small molecule inhibitors have been identified. But turning high affinity inhibitors into clinically viable drug candidates has remained a challenge. We discuss here the latest developments and the future challenges in drug discovery for Botulinum neurotoxins.

Challenges and Future in Vaccines, Drug Development, and Immunomodulatory Therapy

PubMed Central

Nau, Gerard J.; Ross, Ted M.; Evans, Thomas G.; Chakraborty, Krishnendu; Empey, Kerry M.; Flynn, JoAnne L.

2014-01-01

Pulmonary diseases and infections are among the top contributors to human morbidity and mortality worldwide, and despite the successful history of vaccines and antimicrobial therapeutics, infectious disease still presents a significant threat to human health. Effective vaccines are frequently unavailable in developing countries, and successful vaccines have yet to be developed for major global maladies, such as tuberculosis. Furthermore, antibiotic resistance poses a growing threat to human health. The “Challenges and Future in Vaccines, Drug Development, and Immunomodulatory Therapy” session of the 2013 Pittsburgh International Lung Conference highlighted several recent and current studies related to treatment and prevention of antibiotic-resistant bacterial infections, highly pathogenic influenza, respiratory syncytial virus, and tuberculosis. Research presented here focused on novel antimicrobial therapies, new vaccines that are either in development or currently in clinical trials, and the potential for immunomodulatory therapies. These studies are making important contributions to the areas of microbiology, virology, and immunology related to pulmonary diseases and infections and are paving the way for improvements in the efficacy of vaccines and antimicrobials. PMID:25148426

The Legal Past, Present and Future of Prenatal Genetic Testing: Professional Liability and Other Legal Challenges Affecting Patient Access to Services.

PubMed

Pergament, Deborah; Ilijic, Katie

2014-12-15

This chapter is an overview of the current status of the law in the United States regarding prenatal genetic testing with an emphasis on issues related to professional liability and other challenges affecting patient access to prenatal genetic testing. The chapter discusses the roles that federal regulations, promulgated by the Centers for Medicare and Medicaid Services (CMS), the Food and Drug Administration (FDA) and the Federal Trade Commission (FTC), play in the regulation of prenatal genetic tests. The chapter discusses tort litigation based on allegations of malpractice in the provision of prenatal genetic testing and how courts have analyzed issues related to causation, damages and mitigation of damages. The chapter provides reference information regarding how individual states address causes of action under the tort theories of wrongful birth and wrongful life. The chapter concludes with a discussion of future legal issues that may affect clinical prenatal genetic testing services arising from the continued expansion of prenatal genetic testing, legal restrictions on access to abortion and the potential development of embryonic treatments.

Approaches to Peripheral Nerve Repair: Generations of Biomaterial Conduits Yielding to Replacing Autologous Nerve Grafts in Craniomaxillofacial Surgery

PubMed Central

Knipfer, Christian; Hadlock, Tessa

2016-01-01

Peripheral nerve injury is a common clinical entity, which may arise due to traumatic, tumorous, or even iatrogenic injury in craniomaxillofacial surgery. Despite advances in biomaterials and techniques over the past several decades, reconstruction of nerve gaps remains a challenge. Autografts are the gold standard for nerve reconstruction. Using autografts, there is donor site morbidity, subsequent sensory deficit, and potential for neuroma development and infection. Moreover, the need for a second surgical site and limited availability of donor nerves remain a challenge. Thus, increasing efforts have been directed to develop artificial nerve guidance conduits (ANCs) as new methods to replace autografts in the future. Various synthetic conduit materials have been tested in vitro and in vivo, and several first- and second-generation conduits are FDA approved and available for purchase, while third-generation conduits still remain in experimental stages. This paper reviews the current treatment options, summarizes the published literature, and assesses future prospects for the repair of peripheral nerve injury in craniomaxillofacial surgery with a particular focus on facial nerve regeneration. PMID:27556032

Can Tai Chi and Qigong Postures Shape Our Mood? Toward an Embodied Cognition Framework for Mind-Body Research

PubMed Central

Osypiuk, Kamila; Thompson, Evan; Wayne, Peter M.

2018-01-01

Dynamic and static body postures are a defining characteristic of mind-body practices such as Tai Chi and Qigong (TCQ). A growing body of evidence supports the hypothesis that TCQ may be beneficial for psychological health, including management and prevention of depression and anxiety. Although a variety of causal factors have been identified as potential mediators of such health benefits, physical posture, despite its visible prominence, has been largely overlooked. We hypothesize that body posture while standing and/or moving may be a key therapeutic element mediating the influence of TCQ on psychological health. In the present paper, we summarize existing experimental and observational evidence that suggests a bi-directional relationship between body posture and mental states. Drawing from embodied cognitive science, we provide a theoretical framework for further investigation into this interrelationship. We discuss the challenges involved in such an investigation and propose suggestions for future studies. Despite theoretical and practical challenges, we propose that the role of posture in mind-body exercises such as TCQ should be considered in future research. PMID:29765313

Possibilities of ICT-supported services in the clinical management of older adults.

PubMed

Vollenbroek-Hutten, Miriam; Jansen-Kosterink, Stephanie; Tabak, Monique; Feletti, Luca Carlo; Zia, Gianluca; N'dja, Aurèle; Hermens, Hermie

2017-02-01

Services making use of information and communication technology (ICT) are of potential interest to face the challenges of our aging society. Aim of this article is to describe the possible field of application for ICT-supported services in the management of older adults, in particular those with functional impairment. The current status of ICT-supported services is described and examples of how these services can be implemented in everyday practice are given. Upcoming technical solutions and future directions are also addressed. An ICT-supported service is not only the technological tool, but its combination with clinical purposes for which it is used and the way it is implemented in everyday care. Patient's satisfaction with ICT-supported services is moderate to good. Actual use of patients is higher than those of professionals but very variable. Frequency of use is positively related to clinical outcome. ICT offers a variety of opportunities for the treatment and prevention of frailty and functional decline. Future challenges are related to the intelligence of the systems and making the technologies even more unobtrusive and intuitive.

The "New" America Electronic Medical Record (EMR)-design criteria and challenge.

PubMed

Grams, Ralph

2009-12-01

As you can see from a review of the physician interface, there are many exciting potentials that exist for the future of the EMR. None of these will happen unless we change the focus of the system design process and start by making the physician a key and primary player in this equation. To get a proactive physician following is the most important step forward and should be a primary focus for the large investments that are planned. We need a company or organization that sees the need for a future product that will accomplish these goals. We need funding for that process and a prototype development effort to perfect the design. We need the construction of a relational database of medicine with a professional staff to support its operation. Are there entrepreneurs still out there that can see this challenge and are willing to invest in its accomplishment? I sure hope so and I would be delighted to hear from you by email. Please send your comments and critique to: kqinc@aol.com

Can Tai Chi and Qigong Postures Shape Our Mood? Toward an Embodied Cognition Framework for Mind-Body Research.

PubMed

Osypiuk, Kamila; Thompson, Evan; Wayne, Peter M

2018-01-01

Dynamic and static body postures are a defining characteristic of mind-body practices such as Tai Chi and Qigong (TCQ). A growing body of evidence supports the hypothesis that TCQ may be beneficial for psychological health, including management and prevention of depression and anxiety. Although a variety of causal factors have been identified as potential mediators of such health benefits, physical posture, despite its visible prominence, has been largely overlooked. We hypothesize that body posture while standing and/or moving may be a key therapeutic element mediating the influence of TCQ on psychological health. In the present paper, we summarize existing experimental and observational evidence that suggests a bi-directional relationship between body posture and mental states. Drawing from embodied cognitive science, we provide a theoretical framework for further investigation into this interrelationship. We discuss the challenges involved in such an investigation and propose suggestions for future studies. Despite theoretical and practical challenges, we propose that the role of posture in mind-body exercises such as TCQ should be considered in future research.

The Legal Past, Present and Future of Prenatal Genetic Testing: Professional Liability and Other Legal Challenges Affecting Patient Access to Services

PubMed Central

Pergament, Deborah; Ilijic, Katie

2014-01-01

This chapter is an overview of the current status of the law in the United States regarding prenatal genetic testing with an emphasis on issues related to professional liability and other challenges affecting patient access to prenatal genetic testing. The chapter discusses the roles that federal regulations, promulgated by the Centers for Medicare and Medicaid Services (CMS), the Food and Drug Administration (FDA) and the Federal Trade Commission (FTC), play in the regulation of prenatal genetic tests. The chapter discusses tort litigation based on allegations of malpractice in the provision of prenatal genetic testing and how courts have analyzed issues related to causation, damages and mitigation of damages. The chapter provides reference information regarding how individual states address causes of action under the tort theories of wrongful birth and wrongful life. The chapter concludes with a discussion of future legal issues that may affect clinical prenatal genetic testing services arising from the continued expansion of prenatal genetic testing, legal restrictions on access to abortion and the potential development of embryonic treatments. PMID:26237611

Biomarkers in systemic lupus erythematosus: challenges and prospects for the future

PubMed Central

Kao, Amy H.; Manzi, Susan; Ahearn, Joseph M.

2013-01-01

The search for lupus biomarkers to diagnose, monitor, stratify, and predict individual response to therapy is currently more intense than ever before. This effort is essential for several reasons. First, epidemic overdiagnosis and underdiagnosis of lupus, even by certified rheumatologists, leads to errors in therapy with concomitant side effects which may be more serious than the disease itself. Second, identification of lupus flares remains as much an art as it is a science. Third, the capacity to stratify patients so as to predict those who will develop specific patterns of organ involvement is not currently possible but would potentially lead to preventive therapeutic strategies. Fourth, only one new drug for the treatment of lupus has been approved by the US Food and Drug Administration in over 50 years. A major obstacle in this pipeline is the dearth of biomarkers available to prove a patient has responded to an experimental therapeutic intervention. This review will summarize the challenges faced in the discovery and validation of lupus biomarkers, the most promising lupus biomarkers identified to date, and the promise of future directions. PMID:23904865

Learning From The Past and Planning For The Future: The Challenges Of And Solutions For Integrating Aging Into Doctoral Psychology Training

PubMed Central

Holtzer, Roee; Zweig, Richard A.; Siegel, Lawrence J.

2013-01-01

The long forecast “elder boom” has begun. Beginning in 2011, ten thousand members of the “baby boom” generation began turning 65 each day. This demographic shift in our society mandates that pre-doctoral programs in clinical psychology incorporate aging as an integral component of their core and elective training. While fully supporting the concept of broad and general training for predoctoral professional psychology programs, we maintain that the infusion of aging into doctoral psychology training curricula has been inadequate. In this manuscript we provide an overview of geropsychology training models and discuss the challenges involved in incorporating aging to the curriculum of pre-doctoral training in clinical psychology. Potential solutions and examples for accelerating infusion of aging knowledge base are discussed in the context of different geropsychology training models. We conclude that providing services to this rapidly growing segment of our population presents both an employment opportunity to broaden the reach of our profession as well as an ethical responsibility to train future professionals who will practice within their area of knowledge and expertise. PMID:23483705

Renewable Electricity Futures: Exploration of a U.S. Grid with 80% Renewable Electricity

NASA Astrophysics Data System (ADS)

Mai, Trieu

2013-04-01

Renewable Electricity Futures is an initial investigation of the extent to which renewable energy supply can meet the electricity demands of the contiguous United States over the next several decades. This study explores the implications and challenges of very high renewable electricity generation levels: from 30% up to 90% (focusing on 80%) of all U.S. electricity generation from renewable technologies in 2050. At such high levels of renewable electricity penetration, the unique characteristics of some renewable resources, specifically geographical distribution and variability and un-certainty in output, pose challenges to the operability of the nation's electric system. The study focuses on key technical implications of this environment from a national perspective, exploring whether the U.S. power system can supply electricity to meet customer demand on an hourly basis with high levels of renewable electricity, including variable wind and solar generation. The study also identifies some of the potential economic, environmental, and social implications of deploying and integrating high levels of renewable electricity in the U.S. The full report and associated supporting information is available at: http://www.nrel.gov/analysis/refutures/.

Graphene: A Cathode Material of Choice for Aluminium-ion Battery.

PubMed

Das, Shyamal

2018-03-22

The pairing of an aluminum anode with a cathode of high energy and power densities determines the future of aluminum-ion battery technology. The arising natural question is - "Is there any suitable cathode material which is capable of storing sufficiently large amount of trivalent aluminum-ions at relatively higher operating potential?". The wonder material "graphene" emerges to be a befitting answer. Graphene footprint in research arena of aluminum-ion battery could be seen merely three years ago. However, the research progress in this front is tremendous and applauding. Outperforming all other known cathode materials, graphene made several remarkable breakthroughs in offering extraordinary energy density, power density, cycle life, thermal stability, safety and flexibility. The future of Al-graphene couple is indeed brighter, if utmost emphasis is drawn right away to surmount the inherent technological challenges. This minireview comprehensively highlights the electrochemical performances, advantages and challenges of graphene as cathode in aluminum-ion battery in conjugation with chloroaluminate based electrolytes. Additionally, the complex mechanism of charge storage in graphene is also elaborated. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

A Vision of Quantitative Imaging Technology for Validation of Advanced Flight Technologies

NASA Technical Reports Server (NTRS)

Horvath, Thomas J.; Kerns, Robert V.; Jones, Kenneth M.; Grinstead, Jay H.; Schwartz, Richard J.; Gibson, David M.; Taylor, Jeff C.; Tack, Steve; Dantowitz, Ronald F.

2011-01-01

Flight-testing is traditionally an expensive but critical element in the development and ultimate validation and certification of technologies destined for future operational capabilities. Measurements obtained in relevant flight environments also provide unique opportunities to observe flow phenomenon that are often beyond the capabilities of ground testing facilities and computational tools to simulate or duplicate. However, the challenges of minimizing vehicle weight and internal complexity as well as instrumentation bandwidth limitations often restrict the ability to make high-density, in-situ measurements with discrete sensors. Remote imaging offers a potential opportunity to noninvasively obtain such flight data in a complementary fashion. The NASA Hypersonic Thermodynamic Infrared Measurements Project has demonstrated such a capability to obtain calibrated thermal imagery on a hypersonic vehicle in flight. Through the application of existing and accessible technologies, the acreage surface temperature of the Shuttle lower surface was measured during reentry. Future hypersonic cruise vehicles, launcher configurations and reentry vehicles will, however, challenge current remote imaging capability. As NASA embarks on the design and deployment of a new Space Launch System architecture for access beyond earth orbit (and the commercial sector focused on low earth orbit), an opportunity exists to implement an imagery system and its supporting infrastructure that provides sufficient flexibility to incorporate changing technology to address the future needs of the flight test community. A long term vision is offered that supports the application of advanced multi-waveband sensing technology to aid in the development of future aerospace systems and critical technologies to enable highly responsive vehicle operations across the aerospace continuum, spanning launch, reusable space access and global reach. Motivations for development of an Agency level imagery-based measurement capability to support cross cutting applications that span the Agency mission directorates as well as meeting potential needs of the commercial sector and national interests of the Intelligence, Surveillance and Reconnaissance community are explored. A recommendation is made for an assessment study to baseline current imaging technology including the identification of future mission requirements. Development of requirements fostered by the applications suggested in this paper would be used to identify technology gaps and direct roadmapping for implementation of an affordable and sustainable next generation sensor/platform system.

Future Food Production System Development Pulling From Space Biology Crop Growth Testing in Veggie

NASA Technical Reports Server (NTRS)

Massa, Gioia; Romeyn, Matt; Fritsche, Ralph

2017-01-01

Preliminary crop testing using Veggie indicates the environmental conditions provided by the ISS are generally suitable for food crop production. When plant samples were returned to Earth for analysis, their levels of nutrients were comparable to Earth-grown ground controls. Veggie-grown produce food safety microbiology analysis indicated that space-grown crops are safe to consume. Produce sanitizing wipes were used on-orbit to further reduce risk of foodborne illness. Validation growth tests indicated abiotic challenges of insufficient or excess fluid delivery, potentially reduced air flow leading to excess water, elevated CO2 leading to physiological responses, and microorganisms that became opportunistic pathogens. As NASA works to develop future space food production, several areas of research to define these systems pull from the Veggie technology validation tests. Research into effective, reusable water delivery and water recovery methods for future food production systems arises from abiotic challenges observed. Additionally, impacts of elevated CO2 and refinement of fertilizer and light recipes for crops needs to be assessed. Biotic pulls include methods or technologies to effectively sanitize produce with few consumables and low inputs; work to understand the phytomicrobiome and potentially use it to protect crops or enhance growth; selection of crops with high harvest index and desirable flavors for supplemental nutrition; crops that provide psychosocial benefits, and custom space crop development. Planning for future food production in a deep space gateway or a deep space transit vehicle requires methods of handling and storing seeds, and ensuring space seeds are free of contaminants and long-lived. Space food production systems may require mechanization and autonomous operation, with preliminary testing initiated to identify operations and capabilities that are candidates for automation. Food production design is also pulling from Veggie logistics lessons, as we learn about growing at different scales and move toward developing systems that require less launch mass. Veggie will be used as a test bed for novel food production technologies. Veggie is a relatively simple precursor food production system but the knowledge gained from space biology validation tests in Veggie will have far reaching repercussions on future exploration food production. This work is supported by NASA.

Future Food Production System Development Pulling from Space Biology Crop Growth Testing in Veggie

NASA Technical Reports Server (NTRS)

Massa, G. D.; Romeyn, M. W.; Fritsche, R. F.

2017-01-01

Preliminary crop testing using Veggie indicates the environmental conditions provided by the ISS are generally suitable for food crop production. When plant samples were returned to Earth for analysis, their levels of nutrients were comparable to Earth-grown ground controls. Veggie-grown produce food safety microbiology analysis indicated that space-grown crops are safe to consume. Produce sanitizing wipes were used on-orbit to further reduce risk of foodborne illness. Validation growth tests indicated abiotic challenges of insufficient or excess fluid delivery, potentially reduced air flow leading to excess water, elevated CO2 leading to physiological responses, and microorganisms that became opportunistic pathogens. As NASA works to develop future space food production, several areas of research to define these systems pull from the Veggie technology validation tests. Research into effective, reusable water delivery and water recovery methods for future food production systems arises from abiotic challenges observed. Additionally, impacts of elevated CO2 and refinement of fertilizer and light recipes for crops needs to be assessed. Biotic pulls include methods or technologies to effectively sanitize produce with few consumables and low inputs; work to understand the phytomicrobiome and potentially use it to protect crops or enhance growth; selection of crops with high harvest index and desirable flavors for supplemental nutrition; crops that provide psychosocial benefits, and custom space crop development. Planning for future food production in a deep space gateway or a deep space transit vehicle requires methods of handling and storing seeds, and ensuring space seeds are free of contaminants and long-lived. Space food production systems may require mechanization and autonomous operation, with preliminary testing initiated to identify operations and capabilities that are candidates for automation. Food production design is also pulling from Veggie logistics lessons, as we learn about growing at different scales and move toward developing systems that require less launch mass. Veggie will be used as a test bed for novel food production technologies. Veggie is a relatively simple precursor food production system but the knowledge gained from space biology validation tests in Veggie will have far reaching repercussions on future exploration food production.

Deliberative democracy in health care: current challenges and future prospects.

PubMed

Safaei, Jalil

2015-01-01

There is a vast body of literature on deliberative, participative, or engaged democracy. In the area of health care there is a rapidly expanding literature on deliberative democracy as embodied in various notions of public engagement, shared decision-making (SDM), patient-centered care, and patient/care provider autonomy over the past few decades. It is useful to review such literature to get a sense of the challenges and prospects of introducing deliberative democracy in health care. This paper reviews the key literature on deliberative democracy and SDM in health care settings with a focus on identifying the main challenges of promoting this approach in health care, and recognizing its progress so far for mapping out its future prospects in the context of advanced countries. Several databases were searched to identify the literature pertinent to the subject of this study. A total of 56 key studies in English were identified and reviewed carefully for indications and evidence of challenges and/or promising avenues of promoting deliberative democracy in health care. Time pressure, lack of financial motivation, entrenched professional interests, informational imbalance, practical feasibility, cost, diversity of decisions, and contextual factors are noted as the main challenges. As for the prospects, greater clarity on conception of public engagement and policy objectives, real commitment of the authorities to public input, documenting evidence of the effectiveness of public involvement, development of patient decision supports, training of health professionals in SDM, and use of multiple and flexible methods of engagement leadership suited to specific contexts are the main findings in the reviewed literature. Seeking deliberative democracy in health care is both challenging and rewarding. The challenges have been more or less identified. However, its prospects are potentially significant. Such prospects are more likely to materialize if deliberative democracy is pursued more systematically in the broader sociopolitical domains.

Deliberative democracy in health care: current challenges and future prospects

PubMed Central

Safaei, Jalil

2015-01-01

Background There is a vast body of literature on deliberative, participative, or engaged democracy. In the area of health care there is a rapidly expanding literature on deliberative democracy as embodied in various notions of public engagement, shared decision-making (SDM), patient-centered care, and patient/care provider autonomy over the past few decades. It is useful to review such literature to get a sense of the challenges and prospects of introducing deliberative democracy in health care. Objective This paper reviews the key literature on deliberative democracy and SDM in health care settings with a focus on identifying the main challenges of promoting this approach in health care, and recognizing its progress so far for mapping out its future prospects in the context of advanced countries. Method Several databases were searched to identify the literature pertinent to the subject of this study. A total of 56 key studies in English were identified and reviewed carefully for indications and evidence of challenges and/or promising avenues of promoting deliberative democracy in health care. Results Time pressure, lack of financial motivation, entrenched professional interests, informational imbalance, practical feasibility, cost, diversity of decisions, and contextual factors are noted as the main challenges. As for the prospects, greater clarity on conception of public engagement and policy objectives, real commitment of the authorities to public input, documenting evidence of the effectiveness of public involvement, development of patient decision supports, training of health professionals in SDM, and use of multiple and flexible methods of engagement leadership suited to specific contexts are the main findings in the reviewed literature. Conclusion Seeking deliberative democracy in health care is both challenging and rewarding. The challenges have been more or less identified. However, its prospects are potentially significant. Such prospects are more likely to materialize if deliberative democracy is pursued more systematically in the broader sociopolitical domains. PMID:29355181

Deep Learning in Nuclear Medicine and Molecular Imaging: Current Perspectives and Future Directions.

PubMed

Choi, Hongyoon

2018-04-01

Recent advances in deep learning have impacted various scientific and industrial fields. Due to the rapid application of deep learning in biomedical data, molecular imaging has also started to adopt this technique. In this regard, it is expected that deep learning will potentially affect the roles of molecular imaging experts as well as clinical decision making. This review firstly offers a basic overview of deep learning particularly for image data analysis to give knowledge to nuclear medicine physicians and researchers. Because of the unique characteristics and distinctive aims of various types of molecular imaging, deep learning applications can be different from other fields. In this context, the review deals with current perspectives of deep learning in molecular imaging particularly in terms of development of biomarkers. Finally, future challenges of deep learning application for molecular imaging and future roles of experts in molecular imaging will be discussed.

Gaps analysis for CD metrology beyond the 22nm node

NASA Astrophysics Data System (ADS)

Bunday, Benjamin; Germer, Thomas A.; Vartanian, Victor; Cordes, Aaron; Cepler, Aron; Settens, Charles

2013-04-01

This paper will examine the future for critical dimension (CD) metrology. First, we will present the extensive list of applications for which CD metrology solutions are needed, showing commonalities and differences among the various applications. We will then report on the expected technical limits of the metrology solutions currently being investigated by SEMATECH and others in the industry to address the metrology challenges of future nodes, including conventional CD scanning electron microscopy (CD-SEM) and optical critical dimension (OCD) metrology and new potential solutions such as He-ion microscopy (HeIM, sometimes elsewhere referred to as HIM), CD atomic force microscopy (CD-AFM), CD small-angle x-ray scattering (CD-SAXS), high-voltage scanning electron microscopy (HV-SEM), and other types. A technical gap analysis matrix will then be demonstrated, showing the current state of understanding of the future of the CD metrology space.

Recent Advances in Nuclear Powered Electric Propulsion for Space Exploration

NASA Technical Reports Server (NTRS)

Cassady, R. Joseph; Frisbee, Robert H.; Gilland, James H.; Houts, Michael G.; LaPointe, Michael R.; Maresse-Reading, Colleen M.; Oleson, Steven R.; Polk, James E.; Russell, Derrek; Sengupta, Anita

2007-01-01

Nuclear and radioisotope powered electric thrusters are being developed as primary in-space propulsion systems for potential future robotic and piloted space missions. Possible applications for high power nuclear electric propulsion include orbit raising and maneuvering of large space platforms, lunar and Mars cargo transport, asteroid rendezvous and sample return, and robotic and piloted planetary missions, while lower power radioisotope electric propulsion could significantly enhance or enable some future robotic deep space science missions. This paper provides an overview of recent U.S. high power electric thruster research programs, describing the operating principles, challenges, and status of each technology. Mission analysis is presented that compares the benefits and performance of each thruster type for high priority NASA missions. The status of space nuclear power systems for high power electric propulsion is presented. The paper concludes with a discussion of power and thruster development strategies for future radioisotope electric propulsion systems,

The future water environment--using scenarios to explore the significant water management challenges in England and Wales to 2050.

PubMed

Henriques, C; Garnett, K; Weatherhead, E K; Lickorish, F A; Forrow, D; Delgado, J

2015-04-15

Society gets numerous benefits from the water environment. It is crucial to ensure that water management practices deliver these benefits over the long-term in a sustainable and cost-effective way. Currently, hydromorphological alterations and nutrient enrichment pose the greatest challenges in European water bodies. The rapidly changing climatic and socio-economic boundary conditions pose further challenges to water management decisions and the achievement of policy goals. Scenarios are a strategic tool useful in conducting systematic investigations of future uncertainties pertaining to water management. In this study, the use of scenarios revealed water management challenges for England and Wales to 2050. A set of existing scenarios relevant to river basin management were elaborated through stakeholder workshops and interviews, relying on expert knowledge to identify drivers of change, their interdependencies, and influence on system dynamics. In a set of four plausible alternative futures, the causal chain from driving forces through pressures to states, impacts and responses (DPSIR framework) was explored. The findings suggest that scenarios driven by short-term economic growth and competitiveness undermine current environmental legislative requirements and exacerbate the negative impacts of climate change, producing a general deterioration of water quality and physical habitats, as well as reduced water availability with adverse implications for the environment, society and economy. Conversely, there are substantial environmental improvements under the scenarios characterised by long-term sustainability, though achieving currently desired environmental outcomes still poses challenges. The impacts vary across contrasting generic catchment types that exhibit distinct future water management challenges. The findings suggest the need to address hydromorphological alterations, nutrient enrichment and nitrates in drinking water, which are all likely to be exacerbated in the future. Future-proofing river basin management measures that deal with these challenges is crucial moving forward. The use of scenarios to future-proof strategy, policy and delivery mechanisms is discussed to inform next steps. Copyright © 2014 Elsevier B.V. All rights reserved.

Electromembrane extraction--three-phase electrophoresis for future preparative applications.

PubMed

Gjelstad, Astrid; Pedersen-Bjergaard, Stig

2014-09-01

The purpose of this article is to discuss the principle and the future potential for electromembrane extraction (EME). EME was presented in 2006 as a totally new sample preparation technique for ionized target analytes, based on electrokinetic migration across a supported liquid membrane under the influence of an external electrical field. The principle of EME is presented, and typical performance data for EME are discussed. Most work with EME up to date has been performed with low-molecular weight pharmaceutical substances as model analytes, but the principles of EME should be developed in other directions in the future to fully explore the potential. Recent research in new directions is critically reviewed, with focus on extraction of different types of chemical and biochemical substances, new separation possibilities, new approaches, and challenges related to mass transfer and background current. The intention of this critical review is to give a flavor of EME and to stimulate into more research in the area of EME. Unlike other review articles, the current one is less comprehensive, but put more emphasis on new directions for EME. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.