Science.gov

Sample records for potential market size

  1. Determination of the potential market size and opportunities for biomass to electricity projects in China

    SciTech Connect

    Perlack, R.D.

    1995-08-01

    Efforts are currently underway to assess the market potential and prospects for the US private sector in biomass energy development in Yunnan Province. Among the specific objectives of the study are to: estimate the likely market size and competitiveness of biomass energy, assess the viability of US private sector ventures; assess non-economic factors (e.g., resource, environmental, social, political, institutional) that could affect the viability of biomass energy; and recommend appropriate actions to help stimulate biomass initiatives. Feasibility studies show that biomass projects in Yunnan Province are financially and technically viable. Biomass can be grown and converted to electricity at costs lower than other alternatives. These projects if implemented can ease power shortages and help to sustain the region`s economic growth. The external environmental benefits of integrated biomass projects are also potentially significant. This paper summarizes a two-step screening and rank-ordering process that is being used to identify the best candidate projects for possible US private sector investment. The process uses a set of initial screens to eliminate projects that are not technically feasible to develop. The remaining projects are then rank-ordered using a multicriteria technique.

  2. Current Size and Remaining Market Potential of the U.S. Energy Service Company Industry

    SciTech Connect

    Stuart, Elizabeth; Larsen, Peter H.; Goldman, Charles A.; Gilligan, Donald

    2013-06-27

    In this study, we analyze the market size, growth projections and industry trends in the U.S. ESCO industry, drawing on information from interviews with ESCO executives conducted in late 2012. We define ESCOs as energy service companies for whom performance -based contracting is a key business activity; 45 companies met our definition of an ESCO. We were able to interview 35 of these companies, which represents ~78% response rate. The non-respondent ESCOs were small companies in terms of revenue, representing about 2% of industry revenues.

  3. Thermophotovoltaic energy conversion: Technology and market potential

    SciTech Connect

    Ostrowski, L.J.; Pernisz, U.C.; Fraas, L.M.

    1996-02-01

    This report contains material displayed on poster panels during the Conference. The purpose of the contribution was to present a summary of the business overview of thermophotovoltaic generation of electricity and its market potential. The market analysis has shown that the TPV market, while currently still in an early nucleation phase, is evolving into a range of small niche markets out of which larger-size opportunities can emerge. Early commercial applications on yachts and recreational vehicles which require a quiet and emission-free compact electrical generator fit the current TPV technology and economics. Follow-on residential applications are attractive since they can combine generation of electricity with space and hot water heating in a co-generation system. Development of future markets in transportation, both private and communal or industrial, will be driven by legislation requiring emission-free vehicles, and by a reduction in TPV systems cost. As a result of {open_quote}{open_quote}moving down the learning curve,{close_quote}{close_quote} growing power and consumer markets are predicted to come into reach of TPV systems, a development favored by high overall energy conversion efficiency due to high radiation energy density and to high electric conversion efficiency available with photovoltaic cells. {copyright} {ital 1996 American Institute of Physics.}

  4. Thermophotovoltaic energy conversion: Technology and market potential

    NASA Astrophysics Data System (ADS)

    Ostrowski, Leon J.; Pernisz, Udo C.; Fraas, Lewis M.

    1996-02-01

    This report contains material displayed on poster panels during the Conference. The purpose of the contribution was to present a summary of the business overview of thermophotovoltaic generation of electricity and its market potential. The market analysis has shown that the TPV market, while currently still in an early nucleation phase, is evolving into a range of small niche markets out of which larger-size opportunities can emerge. Early commercial applications on yachts and recreational vehicles which require a quiet and emission-free compact electrical generator fit the current TPV technology and economics. Follow-on residential applications are attractive since they can combine generation of electricity with space and hot water heating in a co-generation system. Development of future markets in transportation, both private and communal or industrial, will be driven by legislation requiring emission-free vehicles, and by a reduction in TPV systems cost. As a result of ``moving down the learning curve,'' growing power and consumer markets are predicted to come into reach of TPV systems, a development favored by high overall energy conversion efficiency due to high radiation energy density and to high electric conversion efficiency available with photovoltaic cells.

  5. Earning potential in multilevel marketing enterprises

    NASA Astrophysics Data System (ADS)

    Legara, Erika Fille; Monterola, Christopher; Juanico, Dranreb Earl; Litong-Palima, Marisciel; Saloma, Caesar

    2008-08-01

    Government regulators and other concerned citizens warily view multilevel marketing enterprises (MLM) because of their close operational resemblance to exploitative pyramid schemes. We analyze two types of MLM network architectures - the unilevel and binary, in terms of growth behavior and earning potential among members. We show that network growth decelerates after reaching a size threshold, contrary to claims of unrestricted growth by MLM recruiters. We have also found that the earning potential in binary MLM’s obey the Pareto “80-20” rule, implying an earning opportunity that is strongly biased against the most recent members. On the other hand, unilevel MLM’s do not exhibit the Pareto earning distribution and earning potential is independent of member position in the network. Our analytical results agree well with field data taken from real-world MLM’s in the Philippines. Our analysis is generally valid and can be applied to other MLM architectures.

  6. Marketing potential of advanced breeding clones

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The accumulation of reducing sugars during cold storage of potato tubers is a serious and costly problem for producers and processors. The degree to which cultivars accumulate reducing sugars during storage determines their processing and market potential. Cultivars or advanced breeding lines with...

  7. Distribution of asset price movement and market potential

    NASA Astrophysics Data System (ADS)

    Kim, Dong Han; Marmi, Stefano

    2015-07-01

    In this article we discuss the distribution of asset price movements by introducing a market potential function. From the principle of free energy minimization we analyze two different kinds of market potentials. We obtain a U-shaped potential when market reversion (i.e. contrarian investors) is dominant. On the other hand, if there are more trend followers, flat and logarithmic potentials appear. By using the cyclically adjusted price-to-earning ratio, which is a common valuation tool, we empirically investigate the market data. By studying long term data we observe the historical change of the market potential of the US stock market. Recent US data show that the market potential looks more like a trend-following potential. Next, we compare the market potentials for 12 different countries. Though some countries have similar market potentials, there are specific examples like Japan which exhibits a very flat potential.

  8. Potential markets for advanced satellite communications

    NASA Technical Reports Server (NTRS)

    Adamson, Steven; Roberts, David; Schubert, Leroy; Smith, Brian; Sogegian, Robert; Walters, Daniel

    1993-01-01

    This report identifies trends in the volume and type of traffic offered to the U.S. domestic communications infrastructure and extrapolates these trends through the year 2011. To describe how telecommunications service providers are adapting to the identified trends, this report assesses the status, plans, and capacity of the domestic communications infrastructure. Cable, satellite, and radio components of the infrastructure are examined separately. The report also assesses the following major applications making use of the infrastructure: (1) Broadband services, including Broadband Integrated Services Digital Network (BISDN), Switched Multimegabit Data Service (SMDS), and frame relay; (2) mobile services, including voice, location, and paging; (3) Very Small Aperture Terminals (VSAT), including mesh VSAT; and (4) Direct Broadcast Satellite (DBS) for audio and video. The report associates satellite implementation of specific applications with market segments appropriate to their features and capabilities. The volume and dollar value of these market segments are estimated. For the satellite applications able to address the needs of significant market segments, the report also examines the potential of each satellite-based application to capture business from alternative technologies.

  9. Framework for State-Level Renewable Energy Market Potential Studies

    EPA Pesticide Factsheets

    This document provides a framework and next steps for state officials who require estimates of renewable energy market potential. The report gives insight into how to conduct a market potential study.

  10. The effect of tick size on trading volume share in three competing stock markets

    NASA Astrophysics Data System (ADS)

    Nagumo, Shota; Shimada, Takashi; Ito, Nobuyasu

    2016-09-01

    The relationship between tick sizes and trading volume share in two and three competing markets is studied theoretically. By introducing a simple model which is equipped with multiple markets and non-strategic traders, we analytically calculate the share. It is shown that share is shifted from a market with a larger tick size to a market with a smaller tick size, and the size of share-shift is determined by difference between tick sizes not by ratio between tick sizes in both cases of two markets and three markets.

  11. Cogeneration development and market potential in China

    SciTech Connect

    Yang, F.; Levine, M.D.; Naeb, J.; Xin, D.

    1996-05-01

    China`s energy production is largely dependent on coal. China currently ranks third in global CO{sub 2} emissions, and rapid economic expansion is expected to raise emission levels even further in the coming decades. Cogeneration provides a cost-effective way of both utilizing limited energy resources and minimizing the environmental impacts from use of fossil fuels. However, in the last 10 years state investments for cogeneration projects in China have dropped by a factor of 4. This has prompted this study. Along with this in-depth analysis of China`s cogeneration policies and investment allocation is the speculation that advanced US technology and capital can assist in the continued growth of the cogeneration industry. This study provides the most current information available on cogeneration development and market potential in China.

  12. An analysis of the market potential of water hyacinth-based systems for municipal wastewater treatment

    NASA Technical Reports Server (NTRS)

    Robinson, A. C.; Gorman, H. J.; Hillman, M.; Lawhon, W. T.; Maase, D. L.; Mcclure, T. A.

    1976-01-01

    The potential U.S. market for tertiary municipal wastewater treatment facilities which make use of water hyacinths was investigated. A baseline design was developed which approximates the "typical" or "average" situation under which hyacinth-based systems can be used. The total market size for tertiary treatment was then estimated for those geographical regions in which hyacinths appear to be applicable. Market penetration of the baseline hyacinth system when competing with conventional chemical and physical processing systems was approximated, based primarily on cost differences. A limited analysis was made of the sensitivity of market penetration to individual changes in these assumptions.

  13. Market potential for guinea fowl (Numidia meleagris) products.

    PubMed

    Madzimure, James; Saina, Happyson; Ngorora, Grace P K

    2011-12-01

    The survey evaluated the market potential for guinea fowl (GF; Numidia meleagris) products in the city of Harare, Zimbabwe. Questionnaires were administered to traders/producers (n = 17), retailers (n = 12), cafeteria industry (n = 33) and consumers (n = 1,680) to establish their perceptions on guinea fowl products. The average household size was 6 ± 2. Each trader sold 10 ± 6.30 keets (mean ± standard error), 33 ± 15.05 growers, 20 ± 12.69 breeders and 20 ± 10.1 crates of 30 eggs per month. Each household consumed 2.5 ± 1.39 kg of GF meat and 3 ± 0.65 dozens of GF eggs per month. Retailers purchased 52 ± 44.42 crates of GF eggs and 41 ± 30.50/kg of GF meat whilst cafeteria purchased 33.6 ± 14 crates of GF eggs and 65.5 ± 33.52 kg of GF meat per month. Growers for breeding were the major product for sale by traders (94.1%) at a price of US$7.50 ± 1.74/bird. Different industries were offering different prices for guinea fowl products because of their scarcity on the market. The mean purchase price per crate of 30 guinea fowl eggs sold to the retail and cafeteria were US$3.00 ± 0.58 and US$4.50 ± 0.50, respectively. The mean purchase prices for GF meat was lower (P < 0.05) for retailers (US$2.5 ± 0.81/kg) than cafeteria (US$3.67 ± 0.83/kg). The challenges faced by producers in the marketing of guinea fowl products included poor supply due to the absence of good road networks to connect source areas and the market, perishability of dressed chickens due to power cuts and poor publicity. Overall, the study showed that there is greater market potential for guinea fowl products and farmers can channel their products through traders, cafeteria and retail industries.

  14. Framework for State-Level Renewable Energy Market Potential Studies

    SciTech Connect

    Kreycik, C.; Vimmerstedt, L.; Doris, E.

    2010-01-01

    State-level policymakers are relying on estimates of the market potential for renewable energy resources as they set goals and develop policies to accelerate the development of these resources. Therefore, accuracy of such estimates should be understood and possibly improved to appropriately support these decisions. This document provides a framework and next steps for state officials who require estimates of renewable energy market potential. The report gives insight into how to conduct a market potential study, including what supporting data are needed and what types of assumptions need to be made. The report distinguishes between goal-oriented studies and other types of studies, and explains the benefits of each.

  15. The Effect of Tick Size on Trading Volume Share in Two Competing Stock Markets

    NASA Astrophysics Data System (ADS)

    Nagumo, Shota; Shimada, Takashi; Yoshioka, Naoki; Ito, Nobuyasu

    2017-01-01

    The relationship between tick sizes and trading volume shares in competing markets is studied theoretically. By introducing a simple model which is equipped with two markets and non-strategic traders, we analytically calculate the steady states. It is shown that a market with a larger tick size is generally deprived of its share by the competing market. However, if traders' preference for the present market because of its major share is strong enough, the market with a larger tick size has a chance to keep a major share in the steady state. These findings are consistent with the previous results obtained from a more complicated artificial market model and also provide a clear understanding of the basic mechanism of market competition.

  16. Individual insurance: health insurers try to tap potential market growth.

    PubMed

    November, Elizabeth A; Cohen, Genna R; Ginsburg, Paul B; Quinn, Brian C

    2009-11-01

    Individual insurance is the only source of health coverage for people without access to employer-sponsored insurance or public insurance. Individual insurance traditionally has been sought by older, sicker individuals who perceive the need for insurance more than younger, healthier people. The attraction of a sicker population to the individual market creates adverse selection, leading insurers to employ medical underwriting--which most states allow--to either avoid those with the greatest health needs or set premiums more reflective of their expected medical use. Recently, however, several factors have prompted insurers to recognize the growth potential of the individual market: a declining proportion of people with employer-sponsored insurance, a sizeable population of younger, healthier people forgoing insurance, and the likelihood that many people receiving subsidies to buy insurance under proposed health insurance reforms would buy individual coverage. Insurers are pursuing several strategies to expand their presence in the individual insurance market, including entering less-regulated markets, developing lower-cost, less-comprehensive products targeting younger, healthy consumers, and attracting consumers through the Internet and other new distribution channels, according to a new study by the Center for Studying Health System Change (HSC). Insurers' strategies in the individual insurance market are unlikely to meet the needs of less-than-healthy people seeking affordable, comprehensive coverage. Congressional health reform proposals, which envision a larger role for the individual market under a sharply different regulatory framework, would likely supersede insurers' current individual market strategies.

  17. Biomagnification and tissue distribution of perfluoroalkyl substances (PFASs) in market-size rainbow trout (Oncorhynchus mykiss).

    PubMed

    Goeritz, Ina; Falk, Sandy; Stahl, Thorsten; Schäfers, Christoph; Schlechtriem, Christian

    2013-09-01

    The present study investigated the biomagnification potential as well as the substance and tissue-specific distribution of perfluoroalkyl substances (PFASs) in market-size rainbow trout (Oncorhynchus mykiss). Rainbow trout with an average body weight of 314 ± 21 g were exposed to perfluorobutane sulfonate (PFBS), perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) in the diet for 28 d. The accumulation phase was followed by a 28-d depuration phase, in which the test animals were fed with nonspiked trout feed. On days 0, 7, 14, 28, 31, 35, 42, and 56 of the present study, fish were sampled from the test basin for PFAS analysis. Biomagnification factors (BMFs) for all test compounds were determined based on a kinetic approach. Distribution factors were calculated for each test compound to illustrate the disposition of PFASs in rainbow trout after 28 d of exposure. Dietary exposure of market-size rainbow trout to PFASs did not result in biomagnification; BMF values were calculated as 0.42 for PFOS, >0.23 for PFNA, >0.18 for PFHxS, >0.04 for PFOA, and >0.02 for PFBS, which are below the biomagnification threshold of 1. Liver, blood, kidney, and skin were identified as the main target tissues for PFASs in market-size rainbow trout. Evidence was shown that despite relative low PFAS contamination, the edible parts of the fish (the fillet and skin) can significantly contribute to the whole-body burden.

  18. Potential markets for a satellite-based mobile communications system

    NASA Technical Reports Server (NTRS)

    Jamieson, W. M.; Peet, C. S.; Bengston, R. J.

    1976-01-01

    The objective of the study was to define the market needs for improved land mobile communications systems. Within the context of this objective, the following goals were set: (1) characterize the present mobile communications industry; (2) determine the market for an improved system for mobile communications; and (3) define the system requirements as seen from the potential customer's viewpoint. The scope of the study was defined by the following parameters: (1) markets were confined to U.S. and Canada; (2) range of operation generally exceeded 20 miles, but this was not restrictive; (3) the classes of potential users considered included all private sector users, and non-military public sector users; (4) the time span examined was 1975 to 1985; and (5) highly localized users were generally excluded - e.g., taxicabs, and local paging.

  19. Building-Integrated Photovoltaics (BIPV): Analysis and US market potential

    NASA Astrophysics Data System (ADS)

    Frantzis, Lisa; Friedman, David; Hill, Sarah; Teagan, Peter; Strong, Steven; Strong, Marilyn

    1995-02-01

    Arthur D. Little, Inc., in conjunction with Solar Design Associates, conducted a study for the US Department of Energy (DOE), Office of Building Technologies (OBT) to determine the market potential for grid-connected, building-integrated photovoltaics (BIPV). This study defines BIPV as two types of applications: (1) where the PV modules are an integral part of the building, often serving as the exterior weathering skin; and (2) the PV modules are mounted on the existing building exterior. Both of these systems are fully integrated with the energy usage of the building and have potential for significant market penetration in the US. Off-grid building applications also offer a near-term market for BIPV, but are not included in the scope of this study.

  20. Assessment of the Geothermal Potential Within the BPA Marketing Area.

    SciTech Connect

    Lund, John W.; Allen, Eliot D.

    1980-07-01

    The potential of geothermal energy is estimated that can be used for direct heat applications and electrical power generation within the Bonneville Power Administration (BPA) marketing area. The BPA marketing area includes three principal states of Oregon, Washington, and Idaho and portions of California, Montana, Wyoming, Nevada, and Utah bordering on these three states. This area covers approximately 384,000 square miles and has an estimated population of 6,760,000. The total electrical geothermal potential within this marketing area is 4077 MW/sub e/ from hydrothermal resources and 16,000 MW/sub e/ from igneous systems, whereas the total thermal (wellhead) potential is 16.15 x 10/sup 15/ Btu/y. Approximately 200 geothermal resource sites were initially identified within the BPA marketing area. This number was then reduced to about 100 sites thought to be the most promising for development by the year 2000. These 100 sites, due to load area overlap, were grouped into 53 composite sites; 21-3/4 within BPA preference customer areas and 31-1/4 within nonpreference customer areas. The geothermal resource potential was then estimated for high-temperature (> 302/sup 0/F = 150/sup 0/C), intermediate-temperature (194 to 302/sup 0/F = 90 to 150/sup 0/C), and low-temperature (< 194/sup 0/F = 90/sup 0/C) resources.

  1. Market potential for solar heating and cooling in buildings

    NASA Technical Reports Server (NTRS)

    1973-01-01

    The use of solar heating and cooling for buildings as a method of conserving fossil fuels is discussed. The residential and commercial end use consumption of energy is tabulated. A survey to project the energy requirements for home and industry heating and cooling is developed. The survey indicates that there is a market potential for solar heating and cooling of buildings. A prediction of three to five billion dollars per year as the potential for solar heating and cooling is made.

  2. 7 CFR 170.6 - How are potential market participants identified for the USDA Farmers Market?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) MISCELLANEOUS MARKETING PRACTICES UNDER THE AGRICULTURAL MARKETING ACT OF 1946...

  3. 7 CFR 170.6 - How are potential market participants identified for the USDA Farmers Market?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) MISCELLANEOUS MARKETING PRACTICES UNDER THE AGRICULTURAL MARKETING ACT OF 1946...

  4. Geothermal hydrothermal direct heat use: US market size and market penetration estimates

    SciTech Connect

    El Sawy, A.H.; Entingh, D.J.

    1980-09-01

    This study estimates the future regional and national market penetration path of hydrothermal geothermal direct heat applications in the United States. A Technology Substitution Model (MARPEN) is developed and used to estimate the energy market shares captured by low-temperature (50 to 150/sup 0/C) hydrothermal geothermal energy systems over the period 1985 to 2020. The sensitivity of hydrothermal direct heat market shares to various government hydrothermal commercialization policies is examined. Several substantive recommendations to help accelerate commercialization of geothermal direct heat utilization in the United States are indicated and possible additional analyses are discussed.

  5. Combined Heat and Power Market Potential for Opportunity Fuels

    SciTech Connect

    Jones, David; Lemar, Paul

    2015-12-01

    This report estimates the potential for opportunity fuel combined heat and power (CHP) applications in the United States, and provides estimates for the technical and economic market potential compared to those included in an earlier report. An opportunity fuel is any type of fuel that is not widely used when compared to traditional fossil fuels. Opportunity fuels primarily consist of biomass fuels, industrial waste products and fossil fuel derivatives. These fuels have the potential to be an economically viable source of power generation in various CHP applications.

  6. Class Size and Sorting in Market Equilibrium: Theory and Evidence. NBER Working Paper No. 13303

    ERIC Educational Resources Information Center

    Urquiola, Miguel; Verhoogen, Eric

    2007-01-01

    This paper examines how schools choose class size and how households sort in response to those choices. Focusing on the highly liberalized Chilean education market, we develop a model in which schools are heterogeneous in an underlying productivity parameter, class size is a component of school quality, households are heterogeneous in income and…

  7. The Population Size of the Lesser Bandicoot (Bandicota bengalensis) in Three Markets in Penang, Malaysia

    PubMed Central

    Khairuddin, Nurul Liyana; Raghazli, Razlina; Sah, Shahrul Anuar Mohd; Shafie, Nur Juliani; Azman, Nur Munira

    2011-01-01

    A study of the population size of Bandicota bengalensis rats in three markets in Penang was conducted from April 2004 through May 2005. Taman Tun Sardon Market (TTS), Batu Lanchang Market (BTLG) and Bayan Lepas Market (BYNLP) were surveyed. Six sampling sessions were conducted in each market for four consecutive nights per session. The total captures of B. bengalensis in TTS, BTLG and BYNLP were 92%, 73% and 89% respectively. The total population of B. bengalensis in TTS was estimated as 265.4 (with a 95% confidence interval of 180.9–424.2). The total population at BTLG was estimated as 69.9 (with a 95% confidence interval of 35.5–148.9). At BYNLP, the total population was estimated as 134.7 (with a 95% confidence interval of 77.8–278.4). In general, adult male rats were captured most frequently at each site (55.19%), followed by adult females (31.69%), juvenile males (9.84%) and juvenile females (3.27%). The results showed that the number of rats captured at each site differed significantly according to sex ratio and maturity (χ2 = 121.45, df = 3, p<0.01). Our results suggest that the population sizes found by the study may not represent the actual population size in each market owing to the low numbers of rats recaptured. This finding might have resulted from the variety of foods available in the markets. PMID:24575219

  8. Transferring diffractive optics from research to commercial applications: Part II - size estimations for selected markets

    NASA Astrophysics Data System (ADS)

    Brunner, Robert

    2014-04-01

    In a series of two contributions, decisive business-related aspects of the current process status to transfer research results on diffractive optical elements (DOEs) into commercial solutions are discussed. In part I, the focus was on the patent landscape. Here, in part II, market estimations concerning DOEs for selected applications are presented, comprising classical spectroscopic gratings, security features on banknotes, DOEs for high-end applications, e.g., for the semiconductor manufacturing market and diffractive intra-ocular lenses. The derived market sizes are referred to the optical elements, itself, rather than to the enabled instruments. The estimated market volumes are mainly addressed to scientifically and technologically oriented optical engineers to serve as a rough classification of the commercial dimensions of DOEs in the different market segments and do not claim to be exhaustive.

  9. Survey of food safety practices on small to medium-sized farms and in farmers markets.

    PubMed

    Harrison, Judy A; Gaskin, Julia W; Harrison, Mark A; Cannon, Jennifer L; Boyer, Renee R; Zehnder, Geoffrey W

    2013-11-01

    As produce consumption has increased, so have foodborne disease outbreaks associated with fresh produce. Little research has addressed food safety practices used on small to medium-sized farms selling locally or in farmers markets. This study evaluated current food safety practices used by farmers on small to medium-sized farms and managers of farmers markets in Georgia, Virginia, and South Carolina based on responses to surveys. Surveys were developed, pretested, and revised before implementation with target audiences and were implemented via mail and the Web to maximize participation, with reminders sent to nonrespondents. Data were collected from 226 farmers and 45 market managers. Frequencies and percentages were calculated for all response variables. Responses from farmers indicated that more than 56% of them use manures. Of those who use manures, 34% use raw or mixtures of raw and composted manure, and over 26% wait fewer than 90 days between application of raw manure and harvest. Over 27% use water sources that have not been tested for safety for irrigation, and 16% use such water sources for washing produce. Over 43% do not sanitize surfaces that touch produce at the farm. Only 33% of farmers always clean transport containers between uses. Responses from market managers indicated that over 42% have no food safety standards in place for the market. Only 2 to 11% ask farmers specific questions about conditions on the farm that could affect product safety. Less than 25% of managers sanitize market surfaces. Only 11% always clean market containers between uses. Over 75% of markets offer no sanitation training to workers or vendors. While farmers and market managers are using many good practices, the results indicate that some practices being used may put consumers at risk of foodborne illness. Consequently, there is a need for training for both farmers and market managers.

  10. A Framework for State-Level Renewable Energy Market Potential Studies

    EPA Pesticide Factsheets

    This document provides a framework/next steps for state officials who require estimates of renewable energy market potential, shows how to conduct a market potential study, and distinguishes between goal-oriented studies and other types of studies.

  11. Scenario projections for future market potentials of biobased bulk chemicals.

    PubMed

    Dornburg, Veronika; Hermann, Barbara G; Patel, Martin K

    2008-04-01

    Three scenario projections for future market potentials of biobased bulk chemicals produced by means of white biotechnology are developed for Europe (EU-25) until the year 2050, and potential nonrenewable energy savings, greenhouse gas emission reduction, and land use consequences are analyzed. These scenarios assume benign, moderate, and disadvantageous conditions for biobased chemicals. The scenario analysis yields a broad range of values for the possible market development of white biotechnology chemicals, that is, resulting in a share of white biotechnology chemicals relative to all organic chemicals of about 7 (or 5 million tonnes), 17.5 (or 26 million tonnes), or 38% (or 113 million tonnes) in 2050. We conclude that under favorable conditions, white biotechnology enables substantial savings of nonrenewable energy use (NREU) and greenhouse gas (GHG) emissions compared to the energy use of the future production of all organic chemicals from fossil resources. Savings of NREU reach up to 17% for starch crops and up to 31% for lignocellulosic feedstock by 2050, and saving percentages for GHG emissions are in a similar range. Parallel to these environmental benefits, economic advantages of up to 75 billion Euro production cost savings arise.

  12. [Sample size calculation in clinical post-marketing evaluation of traditional Chinese medicine].

    PubMed

    Fu, Yingkun; Xie, Yanming

    2011-10-01

    In recent years, as the Chinese government and people pay more attention on the post-marketing research of Chinese Medicine, part of traditional Chinese medicine breed has or is about to begin after the listing of post-marketing evaluation study. In the post-marketing evaluation design, sample size calculation plays a decisive role. It not only ensures the accuracy and reliability of post-marketing evaluation. but also assures that the intended trials will have a desired power for correctly detecting a clinically meaningful difference of different medicine under study if such a difference truly exists. Up to now, there is no systemic method of sample size calculation in view of the traditional Chinese medicine. In this paper, according to the basic method of sample size calculation and the characteristic of the traditional Chinese medicine clinical evaluation, the sample size calculation methods of the Chinese medicine efficacy and safety are discussed respectively. We hope the paper would be beneficial to medical researchers, and pharmaceutical scientists who are engaged in the areas of Chinese medicine research.

  13. Lightweight materials in the light-duty passenger vehicle market: Their market penetration potential and impacts

    SciTech Connect

    Stodolsky, F. |; Vyas, A.; Cuenca, R.

    1995-06-01

    This paper summarizes the results of a lightweight materials study. Various lightweight materials are examined and the most cost effective are selected for further analysis. Aluminum and high-performance polymer matrix composites (PMCS) are found to have the highest potential for reducing the weight of automobiles and passenger-oriented light trucks. Weight reduction potential for aluminum and carbon fiber-based PMCs are computed based on a set of component-specific replacement criteria (such as stiffness and strength), and the consequent incremental cost scenarios are developed. The authors assume that a materials R and D program successfully reduces the cost of manufacturing aluminum and carbon fiber PMC-intensive vehicles. A vehicle choice model is used to project market shares for the lightweight vehicles. A vehicle survival and age-related usage model is employed to compute energy consumption over time for the vehicle stock. After a review of projected costs, the following two sets of vehicles are characterized to compete with the conventional materials vehicles: (1) aluminum vehicles with limited replacement providing 19% weight reduction (AIV-Mid), and (2) aluminum vehicles with the maximum replacement providing 31% weight reduction (AIV-Max). Assuming mass-market introduction in 2005, the authors project a national petroleum energy savings of 3% for AIV-Mid and 5% for AIV-Max in 2030.

  14. The maximum potential market for dengue drugs V 1.0.

    PubMed

    Dow, Geoffrey; Mora, Eric

    2012-11-01

    Drugs offer a complementary approach to vaccines for preventing the progression of symptoms and onset of the severe manifestations of dengue. Despite the rapid maturation of the research and development infrastructure for dengue drugs and the increasing frequency of dengue inhibitors reported in the scientific literature, the potential size of the market for dengue drugs has not been articulated. In the present work, extrapolating from publicly available information, we explored the economic burden attributable to dengue, the impact of dengue vaccines on clinical case loads, a possible alternative to tiered pricing for products for neglected diseases, and defined the maximum potential market for a dengue drug. Our projections suggest that in 2006, the annual global burden of dengue was US $1.7billion. Our proposed alternative to existing tiered pricing structures is that during a temporary period of market exclusivity, individual countries would pay 50% of the per-case equivalent of economic costs saved through the use of a dengue drug. This would yield prices per case of US $13-$239 depending on drug effectiveness and cost of medical and indirect costs and lost productivity in different countries. Assuming that such a pricing scheme was embraced, the maximum potential market for a dengue drug or drugs that on average reduced 40% of economic costs might be as high as US $338million annually. Our simulations suggest that dengue vaccines will begin to reduce the clinical case load of dengue in 2022, but that the number of cases will not decrease below 2006 levels and the proportion vaccinated will remain well below that required for the onset of herd immunity during the period of market exclusivity after the licensure of the first wave of dengue drugs.

  15. The market potential for SMES in electric utility applications. Final report

    SciTech Connect

    Not Available

    1994-06-01

    Superconducting magnetic energy storage (SMES) is an emerging technology with features that are potentially attractive in electric utility applications. This study evaluates the potential for SMES technology in the generation, transmission, distribution, and use of electric energy; the time frame of the assessment is through the year 2030. Comparisons are made with other technology options, including both commercially available and advanced systems such as various peaking generation technologies, transmission stability improvement technologies, and power quality enhancement devices. The methodology used for this study focused on the needs of the market place, the capabilities of S and the characteristics of the competing technologies. There is widespread interest within utilities for the development of SMES technology, but there is no general consensus regarding the most attractive size. Considerable uncertainty exists regarding the eventual costs and benefits of commercial SMES systems, but general trends have been developed based on current industry knowledge. Results of this analysis indicate that as storage capacity increases, cost increases at a rate faster than benefits. Transmission system applications requiring dynamic storage appear to have the most attractive economics. Customer service applications may be economic in the near term, but improved ride-through capability of end-use equipment may limit the size of this market over time. Other applications requiring greater storage capacity appear to be only marginally economic at best.

  16. Geography of Existing and Potential Alternative Fuel Markets in the United States

    SciTech Connect

    Johnson, C.; Hettinger, D.

    2014-11-01

    When deploying alternative fuels, it is paramount to match the right fuel with the right location, in accordance with local market conditions. We used six market indicators to evaluate the existing and potential regional market health for each of the five most commonly deployed alternative fuels: electricity (used by plug-in electric vehicles), biodiesel (blends of B20 and higher), E85 ethanol, compressed natural gas (CNG), and propane. Each market indicator was mapped, combined, and evaluated by industry experts. This process revealed the weight the market indicators should be given, with the proximity of fueling stations being the most important indicator, followed by alternative fuel vehicle density, gasoline prices, state incentives, nearby resources, and finally, environmental benefit. Though markets vary among states, no state received 'weak' potential for all five fuels, indicating that all states have an opportunity to use at least one alternative fuel. California, Illinois, Indiana, Pennsylvania, and Washington appear to have the best potential markets for alternative fuels in general, with each sporting strong markets for four of the fuels. Wyoming showed the least potential, with weak markets for all alternative fuels except for CNG, for which it has a patchy market. Of all the fuels, CNG is promising in the greatest number of states--largely because freight traffic provides potential demand for many far-reaching corridor markets and because the sources of CNG are so widespread geographically.

  17. Markets, religion, community size, and the evolution of fairness and punishment.

    PubMed

    Henrich, Joseph; Ensminger, Jean; McElreath, Richard; Barr, Abigail; Barrett, Clark; Bolyanatz, Alexander; Cardenas, Juan Camilo; Gurven, Michael; Gwako, Edwins; Henrich, Natalie; Lesorogol, Carolyn; Marlowe, Frank; Tracer, David; Ziker, John

    2010-03-19

    Large-scale societies in which strangers regularly engage in mutually beneficial transactions are puzzling. The evolutionary mechanisms associated with kinship and reciprocity, which underpin much of primate sociality, do not readily extend to large unrelated groups. Theory suggests that the evolution of such societies may have required norms and institutions that sustain fairness in ephemeral exchanges. If that is true, then engagement in larger-scale institutions, such as markets and world religions, should be associated with greater fairness, and larger communities should punish unfairness more. Using three behavioral experiments administered across 15 diverse populations, we show that market integration (measured as the percentage of purchased calories) positively covaries with fairness while community size positively covaries with punishment. Participation in a world religion is associated with fairness, although not across all measures. These results suggest that modern prosociality is not solely the product of an innate psychology, but also reflects norms and institutions that have emerged over the course of human history.

  18. Potential Impacts of Reductions in Refinery Activity on Northeast Petroleum Product Markets

    EIA Publications

    2012-01-01

    Potential Impacts of Reductions in Refinery Activity on Northeast Petroleum Product Markets is an update to a previous Energy Information Administration (EIA) report, Reductions in Northeast Refining Activity: Potential Implications for Petroleum Product Markets, released in December 2011. This update analyzes possible market responses and impacts in the event Sunoco's Philadelphia refinery closes this summer, in addition to the recently idled refineries on the East Coast and in the U.S. Virgin Islands.

  19. 75 FR 54852 - National Defense Stockpile Market Impact Committee Request for Public Comments on the Potential...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-09

    ... Comments on the Potential Market Impact of Proposed Stockpile Disposals for Fiscal Year 2012 AGENCY: Bureau... Commerce and State, is seeking public comments on the potential market impact of the proposed disposal... economic effects of all acquisitions and disposals of materials from the stockpile * * * .'' The...

  20. Wind farm production cost: Optimum turbine size and farm capacity in the actual market

    SciTech Connect

    Laali, A.R.; Meyer, J.L.; Bellot, C.; Louche, A.

    1996-12-31

    Several studies are undertaken in R&D Division of EDF in collaboration with ERASME association in order to have a good knowledge of the wind energy production costs. These studies are performed in the framework of a wind energy monitoring project and concern the influence of a few parameters like wind farm capacity, turbine size and wind speed on production costs, through an analysis of the actual market trend. Some 50 manufacturers and 140 different kind of wind turbines are considered for this study. The minimum production cost is situated at 800/900 kW wind turbine rated power. This point will probably move to more important powers in the future. This study is valid only for average conditions and some special parameters like particular climate conditions or lack of infrastructure for a special site the could modify the results shown on the curves. The variety of wind turbines (rated power as a function of rotor diameter, height and specific rated power) in the actual market is analyzed. A brief analysis of the market trend is also performed. 7 refs., 7 figs.

  1. Sizing up the individual market for health insurance: a comparison of survey and administrative data sources.

    PubMed

    Abraham, Jean M; Karaca-Mandic, Pinar; Boudreaux, Michel

    2013-08-01

    Provisions within the Affordable Care Act, including the introduction of subsidized, Exchange-based coverage for lower income Americans lacking access to employer coverage, are expected to greatly expand the size and importance of the individual market. Using multiple federal surveys and administrative data from the National Association of Insurance Commissioners, we generate national-, regional-, and state-level estimates of the individual market. In 2009, the number of nonelderly persons with individual coverage ranged from 9.55 million in the Medical Expenditure Panel Survey to 25.3 million in the American Community Survey. Notable differences also exist between survey estimates and National Association of Insurance Commissioners administrative counts, an outcome likely driven by variation in the type and measurement of individual coverage considered by surveys relative to administrative data. Future research evaluating the impact of the Affordable Care Act coverage provisions must be mindful of differences across surveys and administrative sources as it relates to the measurement of individual market coverage.

  2. Maximizing the existing potential of new foreign markets for anthracite

    SciTech Connect

    Ziolkowski, L.W.; Ahn, Y.K.; Hong, S.P.

    1988-09-01

    The major purposes of this report were to: (1) conduct an in-depth survey of both the technical and marketing problems in the United States Anthracite Industry (predominately in Northeastern Pennsylvania); and (2) make recommendations in areas of technical R and D needs that will enhance the United States export of anthracite to foreign markets (especially Korea). The report identifies various anthracite culm drying and other coal utilization concepts; recommends several anthracite utilization configurations which appear to be the most suitable to the Korean market and a sensitivity analysis on these configurations; and identifies several solutions to resolve some of the problems which were identified relative to: (a) reducing the price of exporting anthracite; (b) the producers quality control activities which relate to meeting the Korean specifications and generally improving the understanding on the contract terms that relate to the encouragement of long term commitments of anthracite by Korea. 33 refs., 23 figs., 33 tabs.

  3. Class Size Reduction and Student Achievement: The Potential Tradeoff between Teacher Quality and Class Size

    ERIC Educational Resources Information Center

    Jepsen, Christopher; Rivkin, Steven

    2009-01-01

    This paper investigates the effects of California's billion-dollar class-size-reduction program on student achievement. It uses year-to-year differences in class size generated by variation in enrollment and the state's class-size-reduction program to identify both the direct effects of smaller classes and related changes in teacher quality.…

  4. VOLTTRON™: Tech-to-Market Best-Practices Guide for Small- and Medium-Sized Commercial Buildings

    SciTech Connect

    Cort, Katherine A.; Haack, Jereme N.; Katipamula, Srinivas; Nicholls, Andrew K.

    2016-07-11

    VOLTTRON™ is an open-source distributed control and sensing platform developed by Pacific Northwest National Laboratory for the U.S. Department of Energy. It was developed to be used by the Office of Energy Efficiency and Renewable Energy to support transactive controls research and deployment activities. VOLTTRON is designed to be an overarching integration platform that could be used to bring together vendors, users, and developers and enable rapid application development and testing. The platform is designed to support modern control strategies, including the use of agent- and transaction-based controls. It also is designed to support the management of a wide range of applications, including heating, ventilation, and air-conditioning systems; electric vehicles; and distributed-energy and whole-building loads. This report was completed as part of the Building Technologies Office’s Technology-to-Market Initiative for VOLTTRON’s Market Validation and Business Case Development efforts. The report provides technology-to-market guidance and best practices related to VOLTTRON platform deployments and commercialization activities for use by entities serving small- and medium-sized commercial buildings. The report characterizes the platform ecosystem within the small- and medium-sized commercial building market and articulates the value proposition of VOLTTRON for three core participants in this ecosystem: 1) platform owners/adopters, 2) app developers, and 3) end-users. The report also identifies key market drivers and opportunities for open platform deployments in the small- and medium-sized commercial building market. Possible pathways to the market are described—laboratory testing to market adoption to commercialization. We also identify and address various technical and market barriers that could hinder deployment of VOLTTRON. Finally, we provide “best practice” tech-to-market guidance for building energy-related deployment efforts serving small- and

  5. Potential niche markets for biodiesel and their effects on agriculture

    SciTech Connect

    Raneses, A.R.; Glaser, L.K.; Price, J.M.

    1996-12-31

    This analysis estimates possible biodiesel demand in three niche markets the biodiesel industry has identified as likely candidates for commercialization: federal fleets, mining, and marine/estuary areas. If a 20-percent biodiesel blend becomes a competitive alternative fuel in the coming years, these markets could demand as much as 379 million liters (100 million gallons) of biodiesel. The Food and Agricultural Policy Simulator, an econometric model of U.S. agriculture, was used to estimate the impacts of 76, 193, and 379 million liters (20, 50, and 100 million gallons) of soybean-oil-based biodiesel production on the agricultural sector. The results indicate the effect of increased soybean oil demand on the soybean complex (beans, oil, and meal) and U.S. farm income would be small, but livestock producers and consumers could benefit from low meat prices.

  6. Assessment of potential future hydrogen markets in the U.S.

    NASA Technical Reports Server (NTRS)

    Kashani, A. K.

    1980-01-01

    Potential future hydrogen markets in the United States are assessed. Future hydrogen markets for various use sectors are projected, the probable range of hydrogen production costs from various alternatives is estimated, stimuli and barriers to the development of hydrogen markets are discussed, an overview of the status of technologies for the production and utilization of hydrogen is presented, and, finally, societal aspects of hydrogen production and utilization are discussed.

  7. Financial market images: A practical approach owing to the secret quantum potential

    NASA Astrophysics Data System (ADS)

    Tahmasebi, F.; Meskinimood, S.; Namaki, A.; Vasheghani Farahani, S.; Jalalzadeh, S.; Jafari, G. R.

    2015-02-01

    We unveil secrets of the financial markets that prove very effective on shaping their future. The question to be answered is why instant high amplitude variations of price returns are never experienced. We deduce that the key to shedding light on this issue is the quantum potential whose existence is due to the entanglement between a price and its prior-day price. Implementing the quantum potential would enable us to sketch a robust pattern for the price return fluctuations of a financial market. As such, we model real markets by the Bohmian quantum approach bearing a quantum potential that guides the price return fluctuations. Strictly speaking, we show that this quantum potential confines the price returns of real markets in a scale-invariant manner, which proves to be different for emerging and efficient markets. By modelling the oil and gold markets we see that a 20 day time scale is enough to exhibit the class difference of the scaling behaviour. The appearance of this characteristic time scale lies in the fact that oil and gold markets are influenced by short- and long-term programs. This statement is supported by the fact that short-term programs are due to the market supply and demand, while long-term programs are due to political and natural factors. In short times the potential is very efficiently controlling the market showing a big margin against a white noise, while in the long run the potential is not as efficient as before tending to look more like a white noise. This is due to the widening of the boundaries disabling the quantum potential efficiency on controlling the market, and hence justifying the model.

  8. Ozonated laundry: An analysis of its applications and market potential. Final report

    SciTech Connect

    Geraghty, D.

    1998-12-01

    This report focuses on one specific electrotechnology application--ozonated laundry. This technology is part of a class called Advanced Oxidation Technologies (AOT), all of which are used to create powerful oxidizing atmospheres for a broad range of applications. The richness of the oxidation atmosphere in these processes is enhanced in some applications by the use of UV light and photosensitive catalysts. Typical oxidants used in AOTs include hydrogen peroxide and ozone. There is some uncertainty about the exact nature of the complex chemical reactions generated by these oxidants, but highly aggressive free radicals such as the hydroxyl radical, and perhaps the hydrogen dioxide radical play a key role. AOTs oxidize and destroy undesired organic compounds and bioaerosols, thereby cleaning, deodorizing, and disinfecting materials with which they make contact. Ozone, the focus of this report, has been used commercially to disinfect drinking water and swimming pools, clean cooling tower water, and more recently, clean laundry. The objective of this report is to summarize the salient features of ozonated laundry and its applications. First, the technology will be described in some detail, including its stage of development. Then, a broad range of applications including real situations will be presented and discussed. The economics of ozonated laundry will be presented and the potential market size for laundry applications will be estimated. The market analysis will continue with a review of the key players offering commercial products. Finally, a value proposition for utilities to use with ozonated laundry will be presented.

  9. Networked Virtual Organizations: A Chance for Small and Medium Sized Enterprises on Global Markets

    NASA Astrophysics Data System (ADS)

    Cellary, Wojciech

    Networked Virtual Organizations (NVOs) are a right answer to challenges of globalized, diversified, and dynamic contemporary economy. NVOs need more than e-trade and outsourcing, namely, they need out-tasking and e-collaboration. To out-task, but retain control on the way a task is performed by an external partner, two integrations are required: (1) integration of computer management systems of enterprises cooperating within an NVO; and (2) integration of cooperating representatives of NVO member enterprises into a virtual team. NVOs provide a particular chance to Small and Medium size Enterprises (SMEs) to find their place on global markets and to play a significant role on them. Requirements for SMEs to be able to successfully join an NVO are analyzed in the paper.

  10. Evidence of market-driven size-selective fishing and the mediating effects of biological and institutional factors

    PubMed Central

    Reddy, Sheila M. W.; Wentz, Allison; Aburto-Oropeza, Octavio; Maxey, Martin; Nagavarapu, Sriniketh; Leslie, Heather M.

    2014-01-01

    Market demand is often ignored or assumed to lead uniformly to the decline of resources. Yet little is known about how market demand influences natural resources in particular contexts, or the mediating effects of biological or institutional factors. Here, we investigate this problem by examining the Pacific red snapper (Lutjanus peru) fishery around La Paz, Mexico, where medium or “plate-sized” fish are sold to restaurants at a premium price. If higher demand for plate-sized fish increases the relative abundance of the smallest (recruit size class) and largest (most fecund) fish, this may be a market mechanism to increase stocks and fishermen’s revenues. We tested this hypothesis by estimating the effect of prices on the distribution of catch across size classes using daily records of prices and catch. We linked predictions from this economic choice model to a staged-based model of the fishery to estimate the effects on the stock and revenues from harvest. We found that the supply of plate-sized fish increased by 6%, while the supply of large fish decreased by 4% as a result of a 13% price premium for plate-sized fish. This market-driven size selection increased revenues (14%) but decreased total fish biomass (−3%). However, when market-driven size selection was combined with limited institutional constraints, both fish biomass (28%) and fishermen’s revenue (22%) increased. These results show that the direction and magnitude of the effects of market demand on biological populations and human behavior can depend on both biological attributes and institutional constraints. Fisheries management may capitalize on these conditional effects by implementing size-based regulations when economic and institutional incentives will enhance compliance, as in the case we describe here, or by creating compliance enhancing conditions for existing regulations. PMID:23865225

  11. Estimating Large-Customer Demand Response Market Potential:Integrating Price and Customer Behavior

    SciTech Connect

    Goldman, Charles; Hopper, Nicole; Bharvirkar, Ranjit; Neenan,Bernie; Cappers, Peter

    2007-06-01

    ABSTRACT=Demand response (DR) is increasingly recognized asan essential ingredient to well-functioning electricity markets. DRmarket potential studies can answer questions about the amount of DRavailable in a given area, from which market segments. Several recent DRmarket potential studies have been conducted, most adapting techniquesused to estimate energy-efficiency (EE) potential. In this scoping study,we: reviewed and categorized seven recent DR market potential studies;recommended a methodology for estimating DR market potential for large,non-residential utility customers that uses price elasticities to accountfor behavior and prices; compiled participation rates and elasticityvalues from six DR options offered to large customers in recent years,and demonstrated our recommended methodology with large customer marketpotential scenarios at an illustrative Northeastern utility. We recommendan elasticity approach for large-customer DR options that rely oncusto!

  12. Technology transfer potential of an automated water monitoring system. [market research

    NASA Technical Reports Server (NTRS)

    Jamieson, W. M.; Hillman, M. E. D.; Eischen, M. A.; Stilwell, J. M.

    1976-01-01

    The nature and characteristics of the potential economic need (markets) for a highly integrated water quality monitoring system were investigated. The technological, institutional and marketing factors that would influence the transfer and adoption of an automated system were studied for application to public and private water supply, public and private wastewater treatment and environmental monitoring of rivers and lakes.

  13. CANDLES AND INCENSE AS POTENTIAL SOURCES OF INDOOR AIR POLLUTION: MARKET ANALYSIS AND LITERATURE SEARCH

    EPA Science Inventory

    The report summarizes available information on candles and incense as potential sources of indoor air pollution. It covers market information and a review of the scientific literature. The market information collected focuses on production and sales data, typical uses in the U.S....

  14. Potential of the Social Media as Instruments of Higher Education Marketing: A Segmentation Study

    ERIC Educational Resources Information Center

    Constantinides, Efthymios; Zinck Stagno, Marc C.

    2011-01-01

    The importance of social media as platforms of social interaction, communication and marketing is growing. Increasing numbers of businesses in various industries have already integrated or plan to integrate social media applications into their marketing programs. Higher education institutions show increased interest in the potential of social…

  15. Historical Research and Medium-Sized Public Libraries: The Potential.

    ERIC Educational Resources Information Center

    Piehl, Charles K.

    1982-01-01

    Discusses the special collections and archival materials often found in medium-sized public libraries which should be fully used by historical researchers. It is suggested that public libraries need to advertise their collections which are of historical interest and to be more aware of the needs of the historical researcher. (Author/JL)

  16. Reductions in Northeast Refining Activity: Potential Implications for Petroleum Product Markets

    EIA Publications

    2011-01-01

    This report is the Energy Information Administration's (EIA) initial effort to provide information and analysis on the potential impacts on petroleum product markets from reductions in Northeast petroleum refining activity.

  17. A Methodology for Estimating Large-Customer Demand Response MarketPotential

    SciTech Connect

    Goldman, Charles; Hopper, Nicole; Bharvirkar, Ranjit; Neenan,Bernie; Cappers,Peter

    2007-08-01

    Demand response (DR) is increasingly recognized as an essential ingredient to well-functioning electricity markets. DR market potential studies can answer questions about the amount of DR available in a given area and from which market segments. Several recent DR market potential studies have been conducted, most adapting techniques used to estimate energy-efficiency (EE) potential. In this scoping study, we: reviewed and categorized seven recent DR market potential studies; recommended a methodology for estimating DR market potential for large, non-residential utility customers that uses price elasticities to account for behavior and prices; compiled participation rates and elasticity values from six DR options offered to large customers in recent years, and demonstrated our recommended methodology with large customer market potential scenarios at an illustrative Northeastern utility. We observe that EE and DR have several important differences that argue for an elasticity approach for large-customer DR options that rely on customer-initiated response to prices, rather than the engineering approaches typical of EE potential studies. Base-case estimates suggest that offering DR options to large, non-residential customers results in 1-3% reductions in their class peak demand in response to prices or incentive payments of $500/MWh. Participation rates (i.e., enrollment in voluntary DR programs or acceptance of default hourly pricing) have the greatest influence on DR impacts of all factors studied, yet are the least well understood. Elasticity refinements to reflect the impact of enabling technologies and response at high prices provide more accurate market potential estimates, particularly when arc elasticities (rather than substitution elasticities) are estimated.

  18. One Size Fits All? Slow Cortical Potentials Neurofeedback: A Review

    ERIC Educational Resources Information Center

    Mayer, Kerstin; Wyckoff, Sarah N.; Strehl, Ute

    2013-01-01

    Objective: The intent of this manuscript was to review all published studies on slow cortical potentials (SCP) neurofeedback for the treatment of ADHD, with emphasis on neurophysiological rationale, study design, protocol, outcomes, and limitations. Method: For review, PubMed, MEDLINE, ERIC, and Google Scholar searches identified six studies and…

  19. Assessment of the market potential for the brushless doubly-fed machine (BDFM)

    SciTech Connect

    Not Available

    1992-12-01

    This report was developed to gain an insight into the potential market for the brushless doubly fed machine (BDFM). The BDFM represents a motor technology which has no known equivalent competition in the marketplace. As a result, all the market analyses carried out, for the BDFM, use current technology motors to gauge performance comparisons in the various market segments. The analyses show that significant opportunities exist for BDFM applications in the adjustable speed drives (ASD) as well as the variable speed generation (VSG) categories. Further opportunities also exist in electric vehicle (EV) technology that is forthcoming. In the ASD sector a 75 hp general purpose pump is identified as the first application area for the BDFM, while a 200 kW system is recommended for the VSG application. Specific target market requirements for an electric motor and BDFM application potential in future target markets are also analyzed. The format of the report (i.e. broad and fine market segmentation, and market requirements analyses) represents a framework that equipment manufacturers could use to address specific target markets and develop strategies to meet customer expectations in each of these segments. An update on the current status of electric vehicle technology and the implications for the BDFM are also included for completeness of the report.

  20. Assessment of the market potential for the brushless doubly-fed machine (BDFM). Final report

    SciTech Connect

    Not Available

    1992-12-01

    This report was developed to gain an insight into the potential market for the brushless doubly fed machine (BDFM). The BDFM represents a motor technology which has no known equivalent competition in the marketplace. As a result, all the market analyses carried out, for the BDFM, use current technology motors to gauge performance comparisons in the various market segments. The analyses show that significant opportunities exist for BDFM applications in the adjustable speed drives (ASD) as well as the variable speed generation (VSG) categories. Further opportunities also exist in electric vehicle (EV) technology that is forthcoming. In the ASD sector a 75 hp general purpose pump is identified as the first application area for the BDFM, while a 200 kW system is recommended for the VSG application. Specific target market requirements for an electric motor and BDFM application potential in future target markets are also analyzed. The format of the report (i.e. broad and fine market segmentation, and market requirements analyses) represents a framework that equipment manufacturers could use to address specific target markets and develop strategies to meet customer expectations in each of these segments. An update on the current status of electric vehicle technology and the implications for the BDFM are also included for completeness of the report.

  1. Stocking density effects on production characteristics and body composition of market size cobia, Rachycentron canadum, reared in recirculating aquaculture systems

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Production density in excess of a critical threshold can result in a negative relationship between stocking density and fish production. This study was conducted to evaluate production characteristics of juvenile cobia Rachycentron canadum, reared to market size in production-scale recirculating aq...

  2. Evaluation of a low-head recirculating aquaculture system used for rearing Florida pompano to market size

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A low-head recirculating aquaculture system (RAS) was evaluated for the production Florida pompano Trachinotus carolinus from juvenile to market size. The RAS consisted of three dual-drain, 3-m diameter culture tanks of 7.8 m3 volume each, two 0.7-m3 moving bed bioreactors filled 67% with K1 kaldnes...

  3. Production characteristics of Florida pompano reared to market size at two different densities in low salinity recirculating aquaculture systems

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Florida pompano Trachinotus carolinus, a high-value carangid, is widely recognized as an excellent candidate for commercial mariculture. While results of a recent study indicated that pompano can be successfully reared to market size in small scale recirculating aquaculture systems (RAS) at low...

  4. Effects of no feeding, maintenance feeding, and refeeding on production and processing characteristics of market-size hybrid catfish

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A pond study was initiated to evaluate effects of no feeding, maintenance feeding, and refeeding on production and processing characteristics of market-size hybrid catfish (female Channel Catfish Ictalurus punctatus × male Blue Catfish I. furcatus). Fish with an average weight of 644 g were stocked ...

  5. Personnel Characteristics, Job Satisfaction, and Organizational Styles of Television Program Directors Over Market Ranks and Station Sizes.

    ERIC Educational Resources Information Center

    Fish, Marjorie; Adams, R. C.

    A study compared the organizational styles of television station program directors (PDs) against indicators of market and department size, personnel stability, job satisfaction, and productivity. Researchers used the four types of management styles used by Likert: exploitative authoritarian, benevolent authoritarian, consultative, and…

  6. Examination of Potential Benefits of an Energy Imbalance Market in the Western Interconnection

    SciTech Connect

    Milligan, M.; Clark, K.; King, J.; Kirby, B.; Guo, T.; Liu, G.

    2013-03-01

    In the Western Interconnection, there is significant interest in improving approaches to wide-area coordinated operations of the bulk electric power system, in part because of the increasing penetration of variable generation. One proposed solution is an energy imbalance market. This study focused on that approach alone, with the goal of identifying the potential benefits of an energy imbalance market in the year 2020.

  7. 78 FR 68028 - National Defense Stockpile Market Impact Committee Request for Public Comments on the Potential...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-13

    ... foreign economic effects of all acquisitions and disposals involving the stockpile and related material... disposals of materials from the stockpile. . . .'' The Committee must also balance market impact concerns..., potential disposal, or potential upgrade) associated with each material in its proposed FY 2015...

  8. Prediction markets and their potential role in biomedical research--a review.

    PubMed

    Pfeiffer, Thomas; Almenberg, Johan

    2010-01-01

    Predictions markets are marketplaces for trading contracts with payoffs that depend on the outcome of future events. Popular examples are markets on the outcome of presidential elections, where contracts pay $1 if a specific candidate wins the election and $0 if someone else wins. Contract prices on prediction markets can be interpreted as forecasts regarding the outcome of future events. Further attractive properties include the potential to aggregate private information, to generate and disseminate a consensus among the market participants, and to offer incentives for the acquisition of information. It has been argued that these properties might be valuable in the context of scientific research. In this review, we give an overview of key properties of prediction markets and discuss potential benefits for science. To illustrate these benefits for biomedical research, we discuss an example application in the context of decision making in research on the genetics of diseases. Moreover, some potential practical problems of prediction market application in science are discussed, and solutions are outlined.

  9. Imported Asian swamp eels (Synbranchidae: Monopterus) in North American live food markets: Potential vectors of non-native parasites

    USGS Publications Warehouse

    Nico, Leo G.; Sharp, Paul; Collins, Timothy M.

    2011-01-01

    Since the 1990s, possibly earlier, large numbers of Asian swamp eels (Synbranchidae: Monopterus spp.), some wild-caught, have been imported live from various countries in Asia and sold in ethnic food markets in cities throughout the USA and parts of Canada. Such markets are the likely introduction pathway of some, perhaps most, of the five known wild populations of Asian swamp eels present in the continental United States. This paper presents results of a pilot study intended to gather baseline data on the occurrence and abundance of internal macroparasites infecting swamp eels imported from Asia to North American retail food markets. These data are important in assessing the potential role that imported swamp eels may play as possible vectors of non-native parasites. Examination of the gastrointestinal tracts and associated tissues of 19 adult-sized swamp eels—identified as M. albus "Clade C"—imported from Vietnam and present in a U.S. retail food market revealed that 18 (95%) contained macroparasites. The 394 individual parasites recovered included a mix of nematodes, acanthocephalans, cestodes, digeneans, and pentastomes. The findings raise concern because of the likelihood that some parasites infecting market swamp eels imported from Asia are themselves Asian taxa, some possibly new to North America. The ecological risk is exacerbated because swamp eels sold in food markets are occasionally retained live by customers and a few reportedly released into the wild. For comparative purposes, M. albus "Clade C" swamp eels from a non-native population in Florida (USA) were also examined and most (84%) were found to be infected with internal macroparasites. The current level of analysis does not allow us to confirm whether these are non-native parasites.

  10. Marketing.

    PubMed

    Chambers, David W

    2010-01-01

    There is not enough marketing of dentistry; but there certainly is too much selling of poor quality service that is being passed off as dentistry. The marketing concept makes the patient and the patients' needs the ultimate criteria of marketing efforts. Myths and good practices for effective marketing that will promote oral health are described under the traditional four "Ps" categories of "product" (best dental care), "place" (availability), "promotion" (advertising and other forms of making patients aware of available services and how to use them), and "price" (the total cost to patients of receiving care).

  11. Marketing.

    ERIC Educational Resources Information Center

    Appel, David L.

    This booklet suggests ways in which institutions--Catholic schools in particular--can move beyond public relations and advertising to engage in the broader arena of marketing with its focus on consumer satisfaction. The first of the book's three chapters reviews the concept of marketing, providing definitions of key terms, clarification of…

  12. Marketing.

    ERIC Educational Resources Information Center

    Maust, Robert N.

    1985-01-01

    Although college administrators may be committed to the concept and need for institutional marketing, even a well-developed marketing plan may not work if it is not clearly organized to address special needs. This article reviews management fads, how to make jargon operational, organizational dynamics, and monitoring fads. (MSE)

  13. Business structure, ethnic shifts in labor markets, and violence: the link between company size, local labor markets, and non-Latino homicide.

    PubMed

    Barranco, Raymond E; Shihadeh, Edward S

    2015-01-01

    Combining several schools of thought, including the civic engagement thesis, we extend current research by linking three things at the county level; firm size, the ethnic composition of labor markets, and violent crime. Our results suggest that larger businesses (based on the average number of persons employed) are more likely to have an external orientation and long recruitment reach, and this is linked to ethnic shifts in labor markets toward Latino workers. Such shifts are in turn associated with high rates of homicide among non-Latinos. Through indirect effects modeling, we find that increases in Black homicide are linked to rises in concentrated poverty, while increases in White homicide are linked to changes in unemployment. We discuss the implications of our findings.

  14. Potential Applications for Nuclear Energy besides Electricity Generation: AREVA Global Perspective of HTR Potential Market

    SciTech Connect

    Soutworth, Finis; Gauthier, Jean-Claude; Lecomte, Michel; Carre, Franck

    2007-07-01

    Energy supply is increasingly showing up as a major issue for electricity supply, transportation, settlement, and process heat industrial supply including hydrogen production. Nuclear power is part of the solution. For electricity supply, as exemplified in Finland and France, the EPR brings an immediate answer; HTR could bring another solution in some specific cases. For other supply, mostly heat, the HTR brings a solution inaccessible to conventional nuclear power plants for very high or even high temperature. As fossil fuels costs increase and efforts to avoid generation of Greenhouse gases are implemented, a market for nuclear generated process heat will develop. Following active developments in the 80's, HTR have been put on the back burner up to 5 years ago. Light water reactors are widely dominating the nuclear production field today. However, interest in the HTR technology was renewed in the past few years. Several commercial projects are actively promoted, most of them aiming at electricity production. ANTARES is today AREVA's response to the cogeneration market. It distinguishes itself from other concepts with its indirect cycle design powering a combined cycle power plant. Several reasons support this design choice, one of the most important of which is the design flexibility to adapt readily to combined heat and power applications. From the start, AREVA made the choice of such flexibility with the belief that the HTR market is not so much in competition with LWR in the sole electricity market but in the specific added value market of cogeneration and process heat. In view of the volatility of the costs of fossil fuels, AREVA's choice brings to the large industrial heat applications the fuel cost predictability of nuclear fuel with the efficiency of a high temperature heat source free of greenhouse gases emissions. The ANTARES module produces 600 MWth which can be split into the required process heat, the remaining power drives an adapted prorated

  15. Building-integrated photovoltaics (BIPV): Analysis and US market potential. Final report

    SciTech Connect

    Frantzis, L.; Friedman, D.; Hill, S.; Teagan, P.; Strong, S.; Strong, M.

    1995-02-01

    Arthur D. Little, Inc., in conjunction with Solar Design Associates, conducted a study for the US Department of Energy (DOE), Office of Building Technologies (OBT) to determine the market potential for grid-connected, building-integrated photovoltaics (BIPV). This study defines BIPV as two types of applications: (1) where the PV modules are an integral part of the building, often serving as the exterior weathering skin; and (2) the PV modules are mounted on the existing building exterior. Both of these systems are fully integrated with the energy usage of the building and have potential for significant market penetration in the US. Off-grid building applications also offer a near-term market for BIPV, but are not included in the scope of this study.

  16. Ciguatoxic Potential of Brown-Marbled Grouper in Relation to Fish Size and Geographical Origin

    PubMed Central

    Chan, Thomas Y. K.

    2015-01-01

    To determine the ciguatoxic potential of brown-marbled grouper (Epinephelus fuscoguttatus) in relation to fish size and geographical origin, this review systematically analyzed: 1) reports of large ciguatera outbreaks and outbreaks with description of the fish size; 2) Pacific ciguatoxin (P-CTX) profiles and levels and mouse bioassay results in fish samples from ciguatera incidents; 3) P-CTX profiles and levels and risk of toxicity in relation to fish size and origin; 4) regulatory measures restricting fish trade and fish size preference of the consumers. P-CTX levels in flesh and size dependency of toxicity indicate that the risk of ciguatera after eating E. fuscoguttatus varies with its geographical origin. For a large-sized grouper, it is necessary to establish legal size limits and control measures to protect public health and prevent overfishing. More risk assessment studies are required for E. fuscoguttatus to determine the size threshold above which the risk of ciguatera significantly increases. PMID:26324735

  17. Ciguatoxic Potential of Brown-Marbled Grouper in Relation to Fish Size and Geographical Origin.

    PubMed

    Chan, Thomas Y K

    2015-11-01

    To determine the ciguatoxic potential of brown-marbled grouper (Epinephelus fuscoguttatus) in relation to fish size and geographical origin, this review systematically analyzed: 1) reports of large ciguatera outbreaks and outbreaks with description of the fish size; 2) Pacific ciguatoxin (P-CTX) profiles and levels and mouse bioassay results in fish samples from ciguatera incidents; 3) P-CTX profiles and levels and risk of toxicity in relation to fish size and origin; 4) regulatory measures restricting fish trade and fish size preference of the consumers. P-CTX levels in flesh and size dependency of toxicity indicate that the risk of ciguatera after eating E. fuscoguttatus varies with its geographical origin. For a large-sized grouper, it is necessary to establish legal size limits and control measures to protect public health and prevent overfishing. More risk assessment studies are required for E. fuscoguttatus to determine the size threshold above which the risk of ciguatera significantly increases.

  18. Shared Solar. Current Landscape, Market Potential, and the Impact of Federal Securities Regulation

    SciTech Connect

    Feldman, David; Brockway, Anna M.; Ulrich, Elaine; Margolis, Robert

    2015-04-01

    This report provides a high-level overview of the current U.S. shared solar landscape and the impact that a given shared solar program’s structure has on requiring federal securities oversight, as well as an estimate of market potential for U.S. shared solar deployment.

  19. Shared Solar. Current Landscape, Market Potential, and the Impact of Federal Securities Regulation

    SciTech Connect

    Feldman, David; Brockway, Anna M.; Ulrich, Elaine; Margolis, Robert

    2015-04-07

    This report provides a high-level overview of the current U.S. shared solar landscape, the impact that a given shared solar program’s structure has on requiring federal securities oversight, as well as an estimate of market potential for U.S. shared solar deployment.

  20. An Analysis of the Market Potential for Distance Learning Opportunities in Transportation Professional Development.

    ERIC Educational Resources Information Center

    Durkop, Brooke R.; Jasek, Debbie; Kuhn, Beverly T.

    The feasibility and sustainability of a distance learning program at the Texas Transportation Institute, which is part of the Texas A&M University system, was investigated. A literature review and online survey of current transportation professionals were conducted to examine the market potential for a distance learning program and to identify…

  1. Assessment of the production and marketing potential for fruits and vegetables in the South. Bulletin No. 269

    SciTech Connect

    Vitelli, V.A.; Bateman, L.; Free, W.J.

    1982-02-01

    The South continues to be an important supply area for commercial vegetable production - 27% of all vegetables for the fresh market were produced in the South in 1977. Although market power has been concentrated in terms of production and marketing, there is renewed interest in locally grown produce, especially for small producers who are located near population centers. Although a large variety of fruits and vegetables were found to offer potential for expansion through direct marketing, the crops with the greatest potential for local farmers' markets are those most preferred in that area. Fruit and vegetables produced for the regional and national markets need a longer shelf life than those produced for direct markets. In general, opportunities for expansion through either regional or national markets are high. Opportunities for expanding the amount of vegetables produced for the processing market were rated low. Only cucumbers and Irish potatoes had good potential. Although evaluations of the potential for expanding production of fruit and vegetable crops for marketing through six alternative types of markets are subjective, they provide an indication of future growth for these marketing options. (ERB)

  2. Stationary market applications potential of solid oxide and solid polymer fuel cell systems

    SciTech Connect

    Baker, J.N.; Fletcher, W.H.

    1996-12-31

    The UK DTI`s Advanced Fuel Cells Programme currently focuses on two main fuel cell technologies, namely the solid oxide and solid polymer systems (SOFC and SPFC), respectively. The provision of accurate and timely market data is regarded as an important part of the overall programme objectives, such as to assist both Government and industry in their appraisals of the technologies. The present study was therefore commissioned against this background, with a complementary study addressing transportation and mobile applications. The results reported herein relate to the stationary market applications potential of both SOFC and SPFC systems.

  3. Geothermal direct heat use: Market potential/penetration analysis for Federal Region 9

    NASA Technical Reports Server (NTRS)

    Powell, W. (Editor); Tang, K. (Editor)

    1980-01-01

    A preliminary study was made of the potential for geothermal direct heat use in Arizona, California, Hawaii, and Nevada (Federal Region 9). An analysis was made of each state to: (1) define the resource, based on the latest available data; (2) assess the potential market growth for geothermal energy; and (3) estimate the market penetration, projected to 2020. Findings of the study include the following: (1) Potentially economical hydrothermal resources exist in all four states of the Region: however, the resource data base is largely incomplete, particularly for low to moderate temperature resources. (2) In terms of beneficial heat, the total hydrothermal resource identified so far for the four states is on the order of 43 Quads, including an estimated 34 Quads of high temperature resources which are suitable for direct as well as electrical applications. (3) In California, Hawaii, and Nevada, the industrial market sector has somewhat greater potential for penetration than the residential/commercial sector. In Arizona, however, the situation is reversed, due to the collocation of two major metropolitan areas (Phoenix and Tucson) with potential geothermal resources.

  4. Pompano reared to market size in RAS: Low salinity culture successful

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Florida pompano, Trachinotus carolinus, are found in coastal waters of the Atlantic Ocean from Massachusetts, USA, to Brazil and throughout the Gulf of Mexico. Due to pompano’s superior market value, interest in its culture developed in the US during the 1960s and 1970s. Research conducted during ...

  5. Advanced Sensors and Controls for Building Applications: Market Assessment and Potential R&D Pathways

    SciTech Connect

    Brambley, Michael R.; Haves, Philip; McDonald, Sean C.; Torcellini, Paul; Hansen, David G.; Holmberg, David; Roth, Kurt

    2005-04-13

    Significant energy savings can be achieved in commercial building operation, along with increased comfort and control for occupants, through the implementation of advanced technologies. This document provides a market assessment of existing building sensors and controls and presents a range of technology pathways (R&D options) for pursuing advanced sensors and building control strategies. This paper is actually a synthesis of five other white papers: the first describes the market assessment including estimates of market potential and energy savings for sensors and control strategies currently on the market as well as a discussion of market barriers to these technologies. The other four cover technology pathways: (1) current applications and strategies for new applications, (2) sensors and controls, (3) networking, security, and protocols and standards, and (4) automated diagnostics, performance monitoring, commissioning, optimal control and tools. Each technology pathway chapter gives an overview of the technology or application. This is followed by a discussion of needs and the current status of the technology. Finally, a series of research topics is proposed.

  6. Tests of scaling and universality of the distributions of trade size and share volume: Evidence from three distinct markets

    NASA Astrophysics Data System (ADS)

    Plerou, Vasiliki; Stanley, H. Eugene

    2007-10-01

    Empirical evidence for scale-invariant distributions in financial data has attracted the research interest of physicists. While the power-law tails of the distribution of stock returns P{R>x}˜x-ζR are becoming increasingly well documented, less understood are the statistics of other closely related microstructural variables such as qi , the number of shares exchanged in trade i (termed the trade size) and QΔt(t)=∑i=1Nqi , the total number of shares exchanged as a result of the N=NΔt trades occurring in a time interval Δt (termed share volume). We analyze the statistical properties of trade size q≡qi and share volume Q≡QΔt(t) by analyzing trade-by-trade data from three large databases representing three distinct markets: (i) 1000 major U.S. stocks for the 2-y period 1994-1995, (ii) 85 major U.K. stocks for the 2-y period 2001-2002, and (iii) 13 major Paris Bourse stocks for the 4.5-y period 1994-1999. We find that, for all three markets analyzed, the cumulative distribution of trade size displays a power-law tail P(q>x)˜x-ζq with exponent ζq<2 within the Lévy stable domain. Our analysis of the exponent estimates of ζq suggests that the exponent value is universal in the following respects: (a) ζq is consistent across stocks within each of the three markets analyzed, and also across different markets, and (b) ζq does not display any systematic dependence on market capitalization or industry sector. We next analyze the distributions of share volume QΔt over fixed time intervals and find that for all three markets P{Q>x}˜x-ζQ with exponent ζQ<2 within the Lévy stable domain. To test the validity for Δt=1day of the power-law distributions found from tick-by-tick data, we analyze a fourth large database containing daily U.S. data, and confirm a value for the exponent ζQ within the Lévy stable domain.

  7. Final Report Phase I Study to Characterize the Market Potential for Non-Motorized Travel

    SciTech Connect

    Hwang, Ho-Ling; Reuscher, Tim; Wilson, Daniel W; Schmoyer, Richard L

    2012-06-01

    The idea of livable communities suggests that people should have the option to utilize non-motorized travel (NMT), specifically walking and bicycling, to conduct their daily tasks. Forecasting personal travel by walk and bike is necessary as part of regional transportation planning, and requires fine detail not only about individual travel, but also on transportation and neighborhood infrastructure. In an attempt to characterize the 'market' potential for NMT, the Office of Planning, Federal Highway Administration (FHWA) funded the Center for Transportation Analysis (CTA) of the Oak Ridge National Laboratory (ORNL) to conduct a study. The objectives of this effort were to identify factors that influence communities to walk and bike and to examine why, or why not, travelers walk and bike in their communities. This study relied on information collected under the 2009 National Household Travel Survey (NHTS) as the major source of data, and was supplemented with data from the American Community Survey (ACS), educational survey, health, employment, and others. Initial statistical screening methods were applied to sort through over 400 potential predictor variables, and examined with various measures (e.g., walk trip per person, walk mileage per person, bike trip per person, bike mileage per person) as the dependent variables. The best geographic level of detail used in the modeling for this study was determined to be the Census block group level for walking and Census tract level for biking. The need for additional supplemental private data (i.e., Walk Scores and Nielsen employment data), and geospatial information that reflects land use and physical environments, became evident after an examination of findings from the initial screening models. To be feasible, in terms of costs and time, the geographic scale of the study region was scaled down to nine selected NHTS add-on regions. These regions were chosen based on various criteria including transit availability

  8. QTL mapping in multiple populations and development stages reveals dynamic quantitative trait loci for fruit size in cucumbers of different market classes

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Fruit size is an important quality trait in cucumber of different market classes. The genetic and molecular basis of fruit size variations in cucumber is not well understood. In this study, we conducted QTL mapping of fruit size in cucumber using three mapping populations developed from cross betwee...

  9. Production of market-size North American strain Atlantic salmon Salmo salar in a land-based recirculation aquaculture system using freshwater

    Technology Transfer Automated Retrieval System (TEKTRAN)

    There is interest in culturing Atlantic salmon Salmo salar to market-size in land-based, closed containment systems that use recirculation aquaculture systems (RAS), as this technology often enables facilities to locate near major markets, obtain permits, exclude obligate pathogens, and/or reduce en...

  10. Evidence from a Large Sample on the Effects of Group Size and Decision-Making Time on Performance in a Marketing Simulation Game

    ERIC Educational Resources Information Center

    Treen, Emily; Atanasova, Christina; Pitt, Leyland; Johnson, Michael

    2016-01-01

    Marketing instructors using simulation games as a way of inducing some realism into a marketing course are faced with many dilemmas. Two important quandaries are the optimal size of groups and how much of the students' time should ideally be devoted to the game. Using evidence from a very large sample of teams playing a simulation game, the study…

  11. U.S. Energy Service Company Industry: Market Size and Project Performance from 1990-2008

    SciTech Connect

    Larsen, Peter; Goldman, Charles; Satchwell, Andrew

    2012-08-21

    The U.S. energy service company (ESCO) industry is an example of a private sector business model where energy savings are delivered to customers primarily through the use of performance-based contracts. This study was conceived as a snapshot of the ESCO industry prior to the economic slowdown and the introduction of federal stimulus funding mandated by enactment of the American Recovery and Reinvestment Act of 2009 (ARRA). This study utilizes two parallel analytic approaches to characterize ESCO industry and market trends in the U.S.: (1) a ?top-down? approach involving a survey of individual ESCOs to estimate aggregate industry activity and (2) a ?bottom-up? analysis of a database of ~;;3,250 projects (representing over $8B in project investment) that reports market trends including installed EE retrofit strategies, project installation costs and savings, project payback times, and benefit-cost ratios over time. Despite the onset of a severe economic recession, the U.S. ESCO industry managed to grow at about 7percent per year between 2006 and 2008. ESCO industry revenues were about $4.1 billion in 2008 and ESCOs anticipate accelerated growth through 2011 (25percent per year). We found that 2,484 ESCO projects in our database generated ~;;$4.0 billion ($2009) in net, direct economic benefits to their customers. We estimate that the ESCO project database includes about 20percent of all U.S. ESCO market activity from 1990-2008. Assuming the net benefits per project are comparable for ESCO projects that are not included in the LBNL database, this would suggest that the ESCO industry has generated ~;;$23 billion in net direct economic benefits for customers at projects installed between 1990 and 2008. There is empirical evidence confirming that the industry is evolving by installing more comprehensive and complex measures?including onsite generation and measures to address deferred maintenance?but this evolution has significant implications for customer project

  12. Solar photo-catalytic hydrogen: systems considerations, economics, and potential markets. Final report

    SciTech Connect

    Steele, R V; Witwer, J G

    1981-05-01

    A three part analysis was done consisting of (1) an examination of the physical principles of solar photocatalytic energy conversion and the status of research in this area, (2) an economic analysis of the potential costs of producing hydrogen from such a system, and (3) an analysis of the markets for hydrogen and the possible penetration of these markets by solar photocatalytic hydrogen. The cost range of flat plate thermal collectors, heliostats, and a photovoltaic system are compared. The cost range of flat plate thermal collectors was used to represent the cost of photocatalytic systems. On the basis of the photovoltaics cost outlook, it is found that photocatalytic systems would not cost less than $180 to $330 per m/sup 2/ range. On the basis of the heliostat cost outlook, a cost lower than $180 to $330 per m could be projected only for very large production volumes and very large installations. (LEW)

  13. Chemicals from Biomass: A Market Assessment of Bioproducts with Near-Term Potential

    SciTech Connect

    Biddy, Mary J.; Scarlata, Christopher; Kinchin, Christopher

    2016-03-23

    Production of chemicals from biomass offers a promising opportunity to reduce U.S. dependence on imported oil, as well as to improve the overall economics and sustainability of an integrated biorefinery. Given the increasing momentum toward the deployment and scale-up of bioproducts, this report strives to: (1) summarize near-term potential opportunities for growth in biomass-derived products; (2) identify the production leaders who are actively scaling up these chemical production routes; (3) review the consumers and market champions who are supporting these efforts; (4) understand the key drivers and challenges to move biomass-derived chemicals to market; and (5) evaluate the impact that scale-up of chemical strategies will have on accelerating the production of biofuels.

  14. The arithmetic problem size effect in children: an event-related potential study

    PubMed Central

    Van Beek, Leen; Ghesquièr, Pol; De Smedt, Bert; Lagae, Lieven

    2014-01-01

    This study used for the first time event-related potentials (ERPs) to examine the well-known arithmetic problem size effect in children. The electrophysiological correlates of this problem size effect have been well documented in adults, but such information in children is lacking. In the present study, 22 typically developing 12-year-olds were asked to solve single-digit addition problems of small (sum ≤ 10) and large problem size (sum > 10) and to speak the solution into a voice key while ERPs were recorded. Children displayed similar early and late components compared to previous adult studies on the problem size effect. There was no effect of problem size on the early components P1, N1, and P2. The peak amplitude of the N2 component showed more negative potentials on left and right anterior electrodes for large additions compared to small additions, which might reflect differences in attentional and working memory resources between large and small problems. The mean amplitude of the late positivity component which follows the N2, was significantly larger for large than for small additions at right parieto-occipital electrodes, in line with previous adult data. The ERPs of the problem size effect during arithmetic might be a useful neural marker for future studies on fact retrieval impairments in children with mathematical difficulties. PMID:25309405

  15. Preferred numbers and the distributions of trade sizes and trading volumes in the Chinese stock market

    NASA Astrophysics Data System (ADS)

    Mu, G.-H.; Chen, W.; Kertész, J.; Zhou, W.-X.

    2009-03-01

    The distributions of trade sizes and trading volumes are investigated based on the limit order book data of 22 liquid Chinese stocks listed on the Shenzhen Stock Exchange in the whole year 2003. We observe that the size distribution of trades for individualstocks exhibits jumps, which is caused by the number preference of traders when placing orders. We analyze the applicability of the “q-Gamma” function for fitting the distribution by the Cramér-von Mises criterion. The empirical PDFs of tradingvolumes at different timescales Δt ranging from 1 min to 240 min can be well modeled. The applicability of the q-Gamma functions for multiple trades is restricted to the transaction numbers Δn≤ 8. We find that all the PDFs have power-law tails for large volumes. Using careful estimation of the average tail exponents α of the distributions of trade sizes and trading volumes, we get α> 2, well outside the Lévy regime.

  16. Response of the plasma to the size of an anode electrode biased near the plasma potential

    SciTech Connect

    Barnat, E. V.; Laity, G. R.; Baalrud, S. D.

    2014-10-15

    As the size of a positively biased electrode increases, the nature of the interface formed between the electrode and the host plasma undergoes a transition from an electron-rich structure (electron sheath) to an intermediate structure containing both ion and electron rich regions (double layer) and ultimately forms an electron-depleted structure (ion sheath). In this study, measurements are performed to further test how the size of an electron-collecting electrode impacts the plasma discharge the electrode is immersed in. This is accomplished using a segmented disk electrode in which individual segments are individually biased to change the effective surface area of the anode. Measurements of bulk plasma parameters such as the collected current density, plasma potential, electron density, electron temperature and optical emission are made as both the size and the bias placed on the electrode are varied. Abrupt transitions in the plasma parameters resulting from changing the electrode surface area are identified in both argon and helium discharges and are compared to the interface transitions predicted by global current balance [S. D. Baalrud, N. Hershkowitz, and B. Longmier, Phys. Plasmas 14, 042109 (2007)]. While the size-dependent transitions in argon agree, the size-dependent transitions observed in helium systematically occur at lower electrode sizes than those nominally derived from prediction. The discrepancy in helium is anticipated to be caused by the finite size of the interface that increases the effective area offered to the plasma for electron loss to the electrode.

  17. Evaluating the acute effects of oral, non-combustible potential reduced exposure products marketed to smokers

    PubMed Central

    Cobb, CO; Weaver, MF; Eissenberg, T

    2011-01-01

    Background Non-combustible potential reduced exposure products (PREPs; eg, Star Scientific’s Ariva; a variety of other smokeless tobacco products) are marketed to reduce the harm associated with smoking. This marketing occurs despite an absence of objective data concerning the toxicant exposure and effects of these PREPs. Methods used to examine combustible PREPs were adapted to assess the acute effects of non-combustible PREPs for smokers. Methods 28 overnight abstinent cigarette smokers (17 men, 14 non-white) each completed seven, Latin-squared ordered, approximately 2.5 h laboratory sessions that differed by product administered: Ariva, Marlboro Snus (Philip Morris, USA), Camel Snus (RJ Reynolds, Winston-Salem, North Carolina, USA), Commit nicotine lozenge (GlaxoSmithKline; 2 mg), own brand cigarettes, Quest cigarettes (Vector Tobacco; delivers very low levels of nicotine) and sham smoking (ie, puffing on an unlit cigarette). In each session, the product was administered twice (separated by 60 min), and plasma nicotine levels, expired air CO and subjective effects were assessed regularly. Results Non-combustible products delivered less nicotine than own brand cigarettes, did not expose smokers to CO and failed to suppress tobacco abstinence symptoms as effectively as combustible products. Conclusions While decreased toxicant exposure is a potential indicator of harm reduction potential, a failure to suppress abstinence symptoms suggests that currently marketed non-combustible PREPs may not be a viable harm reduction strategy for US smokers. This study demonstrates how clinical laboratory methods can be used to evaluate the short-term effects of non-combustible PREPs for smokers. PMID:19346218

  18. Three near term commercial markets in space and their potential role in space exploration

    NASA Astrophysics Data System (ADS)

    Gavert, Raymond B.

    2001-02-01

    Independent market studies related to Low Earth Orbit (LEO) commercialization have identified three near term markets that have return-on-investment potential. These markets are: (1) Entertainment (2) Education (3) Advertising/sponsorship. Commercial activity is presently underway focusing on these areas. A private company is working with the Russians on a commercial module attached to the ISS that will involve entertainment and probably the other two activities as well. A separate corporation has been established to commercialize the Russian Mir Space Station with entertainment and promotional advertising as important revenue sources. A new startup company has signed an agreement with NASA for commercial media activity on the International Space Station (ISS). Profit making education programs are being developed by a private firm to allow students to play the role of an astronaut and work closely with space scientists and astronauts. It is expected that the success of these efforts on the ISS program will extend to exploration missions beyond LEO. The objective of this paper is to extrapolate some of the LEO commercialization experiences to see what might be expected in space exploration missions to Mars, the Moon and beyond. .

  19. Three Essays on the Economics of Education: Class-Size Reduction, Teacher Labor Markets, and Teacher Effectiveness

    ERIC Educational Resources Information Center

    Dieterle, Steven

    2012-01-01

    Prior research has established the potential for achievement gains from attending smaller classes. However, large statewide class-size reduction (CSR) policies have not been found to consistently realize such gains. A leading explanation for the disappointing performance of CSR policies is that schools are forced to hire additional teachers of…

  20. Impact of Size in Pancreatic Islet Transplantation and Potential Interventions to Improve Outcome

    PubMed Central

    Zorzi, Daria; Phan, Tammy; Sequi, Marco; Lin, Yong; Freeman, Daniel H.; Cicalese, Luca; Rastellini, Cristiana

    2015-01-01

    Better results have been recently reported in clinical pancreatic islet transplantation (ITX) due mostly to improved isolation techniques and immunosuppression; however, some limitations still exist. It is known that following transplantation from 30 to 60% of the islets is lost. In our study, we have investigated: 1) the role of size as a factor affecting islet engraftment and, 2) potential procedural manipulations to increase the number of smaller functional islets that can be transplanted. C57/BL10 mice were used as donors and recipients in a syngeneic islet transplant model. Isolated islets were divided by size (large, >300 µm; medium 150–300 µm; small, ρ50 µm). Each size was transplanted in chemically induced diabetic mice as full (600 IEq), suboptimal (400 IEq), and marginal mass (200 IEq). Control animals received all size islets. Engraftment was defined as reversal of diabetes by day 7 post-transplantation. When the superiority of smaller islets was observed, strategies of over-digestion and fragmentation were adopted during islet isolation in the attempt to reduce islet size and improve engraftment. Smaller islets were significantly superior in engraftment as compared to medium, large, and control (all sizes) groups. This was more evident when marginal mass data were compared. In all masses, success decreased as islet sizes increased. Once islets were engrafted, functionality was not affected by size. When larger islets were fragmented, a significant decrease in islet functionality was observed. On the contrary, if pancreata were slightly over-digested, although not as successful as small naive islets, an increase in engraftment was observed when compared to the control group. In conclusion, smaller islets are superior in engraftment following islet transplantation. Fragmentation has a deleterious effect on islet engraftment. Islet isolations can be performed reducing islet size with slight over-digestion and it can be safely adopted to improve

  1. Impact of islet size on pancreatic islet transplantation and potential interventions to improve outcome.

    PubMed

    Zorzi, Daria; Phan, Tammy; Sequi, Marco; Lin, Yong; Freeman, Daniel H; Cicalese, Luca; Rastellini, Cristiana

    2015-01-01

    Better results have been recently reported in clinical pancreatic islet transplantation (ITX) due mostly to improved isolation techniques and immunosuppression; however, some limitations still exist. It is known that following transplantation, 30% to 60% of the islets are lost. In our study, we have investigated 1) the role of size as a factor affecting islet engraftment and 2) potential procedural manipulations to increase the number of smaller functional islets that can be transplanted. C57/BL10 mice were used as donors and recipients in a syngeneic islet transplant model. Isolated islets were divided by size (large, >300 μm; medium 150-300 μm; small, <150 μm). Each size was transplanted in chemically induced diabetic mice as full (600 IEQ), suboptimal (400 IEQ), and marginal mass (200 IEQ). Control animals received all size islets. Engraftment was defined as reversal of diabetes by day 7 posttransplantation. When the superiority of smaller islets was observed, strategies of overdigestion and fragmentation were adopted during islet isolation in the attempt to reduce islet size and improve engraftment. Smaller islets were significantly superior in engraftment compared to medium, large, and control (all sizes) groups. This was more evident when marginal mass data were compared. In all masses, success decreased as islet size increased. Once islets were engrafted, functionality was not affected by size. When larger islets were fragmented, a significant decrease in islet functionality was observed. On the contrary, if pancreata were slightly overdigested, although not as successful as small naive islets, an increase in engraftment was observed when compared to the control group. In conclusion, smaller islets are superior in engraftment following islet transplantation. Fragmentation has a deleterious effect on islet engraftment. Islet isolations can be performed by reducing islet size with slight overdigestion, and it can be safely adopted to improve clinical

  2. Entrapment of ovalbumin into liposomes--factors affecting entrapment efficiency, liposome size, and zeta potential.

    PubMed

    Brgles, Marija; Jurasin, Darija; Sikirić, Maja Dutour; Frkanec, Ruza; Tomasić, Jelka

    2008-01-01

    Various amounts of Ovalbumin (OVA) were encapsulated into positively and negatively charged multilamellar liposomes, with the aim to investigate the entrapment efficiency in different buffers and to study their effects on the liposome size and zeta potential. Results showed that the entrapment efficiency of OVA in anionic liposomes was the same in 10 mM Phosphate Buffer (PB) as in Phosphate-Buffered Saline (PBS; PB + 0.15 M NaCl). Also, liposome size was approximately 1200 nm for all anionic liposomes incorporating OVA. The entrapment efficiency of OVA in cationic liposomes was highly dependent on ionic strength. The size of cationic liposomes was approximately 1200 nm in PBS, regardless of protein content, but increased with the amount of the incorporated protein in PB. Aggregation of cationic liposomes in PB was observed when the mass of the protein was 2.5 mg or greater. The zeta potential of anionic liposomes was negative and of cationic liposomes positive in the whole range of protein mass tested. These results show how different compositions of lipid and aqueous phases can be used to vary the entrapment efficiency, liposome size, and zeta potential--the factors that are of great importance for the use of liposomes as drug carriers.

  3. Electrokinetic mixing at high zeta potentials: ionic size effects on cross stream diffusion.

    PubMed

    Ahmadian Yazdi, Alireza; Sadeghi, Arman; Saidi, Mohammad Hassan

    2015-03-15

    The electrokinetic phenomena at high zeta potentials may show several unique features which are not normally observed. One of these features is the ionic size (steric) effect associated with the solutions of high ionic concentration. In the present work, attention is given to the influences of finite ionic size on the cross stream diffusion process in an electrokinetically actuated Y-shaped micromixer. The method consists of a finite difference based numerical approach for non-uniform grid which is applied to the dimensionless form of the governing equations, including the modified Poisson-Boltzmann equation. The results reveal that, neglecting the ionic size at high zeta potentials gives rise to the overestimation of the mixing length, because the steric effects retard liquid flow, thereby enhancing the mixing efficiency. The importance of steric effects is found to be more intense for channels of smaller width to height ratio. It is also observed that, in sharp contrast to the conditions that the ions are treated as point charges, increasing the zeta potential improves the cross stream diffusion when incorporating the ionic size. Moreover, increasing the EDL thickness decreases the mixing length, whereas the opposite is true for the channel aspect ratio.

  4. Size-dependent error of the density functional theory ionization potential in vacuum and solution

    SciTech Connect

    Sosa Vazquez, Xochitl A.; Isborn, Christine M.

    2015-12-28

    Density functional theory is often the method of choice for modeling the energetics of large molecules and including explicit solvation effects. It is preferable to use a method that treats systems of different sizes and with different amounts of explicit solvent on equal footing. However, recent work suggests that approximate density functional theory has a size-dependent error in the computation of the ionization potential. We here investigate the lack of size-intensivity of the ionization potential computed with approximate density functionals in vacuum and solution. We show that local and semi-local approximations to exchange do not yield a constant ionization potential for an increasing number of identical isolated molecules in vacuum. Instead, as the number of molecules increases, the total energy required to ionize the system decreases. Rather surprisingly, we find that this is still the case in solution, whether using a polarizable continuum model or with explicit solvent that breaks the degeneracy of each solute, and we find that explicit solvent in the calculation can exacerbate the size-dependent delocalization error. We demonstrate that increasing the amount of exact exchange changes the character of the polarization of the solvent molecules; for small amounts of exact exchange the solvent molecules contribute a fraction of their electron density to the ionized electron, but for larger amounts of exact exchange they properly polarize in response to the cationic solute. In vacuum and explicit solvent, the ionization potential can be made size-intensive by optimally tuning a long-range corrected hybrid functional.

  5. Size-dependent error of the density functional theory ionization potential in vacuum and solution

    SciTech Connect

    Sosa Vazquez, Xochitl A.; Isborn, Christine M.

    2015-12-22

    Density functional theory is often the method of choice for modeling the energetics of large molecules and including explicit solvation effects. It is preferable to use a method that treats systems of different sizes and with different amounts of explicit solvent on equal footing. However, recent work suggests that approximate density functional theory has a size-dependent error in the computation of the ionization potential. We here investigate the lack of size-intensivity of the ionization potential computed with approximate density functionals in vacuum and solution. We show that local and semi-local approximations to exchange do not yield a constant ionization potential for an increasing number of identical isolated molecules in vacuum. Instead, as the number of molecules increases, the total energy required to ionize the system decreases. Rather surprisingly, we find that this is still the case in solution, whether using a polarizable continuum model or with explicit solvent that breaks the degeneracy of each solute, and we find that explicit solvent in the calculation can exacerbate the size-dependent delocalization error. We demonstrate that increasing the amount of exact exchange changes the character of the polarization of the solvent molecules; for small amounts of exact exchange the solvent molecules contribute a fraction of their electron density to the ionized electron, but for larger amounts of exact exchange they properly polarize in response to the cationic solute. As a result, in vacuum and explicit solvent, the ionization potential can be made size-intensive by optimally tuning a long-range corrected hybrid functional.

  6. Disruptive Potential of the Internet to Transform Illicit Drug Markets and Impact on Future Patterns of Drug Consumption.

    PubMed

    Griffiths, P; Mounteney, J

    2017-02-01

    The internet facilitates rapid and covert communication, knowledge transfer, and has the potential to disrupt and transform drug market models and associated consumption patterns. Innovation and new trends diffuse rapidly through this medium and new operational models are emerging. Although the online drug markets currently only account for a small share of all drug transactions, the potential of the surface and deep web to provide a new platform for drug sale and exchanges is considerable.

  7. Total radioactive residues and residues of [36Cl]chlorate in market size broilers.

    PubMed

    Smith, David J; Byrd, James A; Anderson, Robin C

    2007-07-11

    The oral administration of chlorate salts reduces the numbers of Gram-negative pathogens in gastrointestinal tracts of live food animals. Although the efficacy of chlorate salts has been demonstrated repeatedly, the technology cannot be introduced into commercial settings without first demonstrating that chlorate residues, and metabolites of chlorate remaining in edible tissues, represent a negligible risk to consumers. Typically, a first step in this risk assessment is to quantify the parent compound and to identify metabolites remaining in edible tissues of animals treated with the experimental compound. The objectives of this study were to determine the pathway(s) of chlorate metabolism in market broilers and to determine the magnitude of chlorate residues remaining in edible tissues. To this end, 12 broilers (6 weeks; 2.70+/-0.34 kg) were randomly assigned to three treatments of 7.4, 15.0, and 22.5 mM sodium [36Cl]chlorate dissolved in drinking water (n=4 broilers per treatment). Exposure to chlorate, dissolved in drinking water, occurred at 0 and 24 h (250 mL per exposure), feed was withdrawn at hour 38, water was removed at hour 48, and birds were slaughtered at hour 54 (16 h after feed removal and 8 h after water removal). The radioactivity was rapidly eliminated in excreta with 69-78% of the total administered radioactivity being excreted by slaughter. Total radioactive residues were proportional to dose in all edible tissues with chloride ion comprising greater than 98.5% of the radioactive residue for the tissue (9.4-97.8 ppm chlorate equivalents). Chlorate residues were typically greatest in the skin (0.33-0.82 ppm), gizzard (0.1-0.137 ppm), and dark muscle (0.05-0.14 ppm). Adipose, liver, and white muscle tissue contained chlorate concentrations from 0.03 to 0.13 ppm. In contrast, chlorate concentrations in excreta eliminated during the 6 h period prior to slaughter ranged from 53 to 71 ppm. Collectively, these data indicate that broilers rapidly

  8. Sauces, spices, and condiments: definitions, potential benefits, consumption patterns, and global markets.

    PubMed

    García-Casal, Maria Nieves; Peña-Rosas, Juan Pablo; Malavé, Heber Gómez-

    2016-09-01

    Spices and condiments are an important part of human history and nutrition, and have played an important role in the development of most cultures around the world. According to the Codex Alimentarius, the category of salts, spices, soups, sauces, salads, and protein products includes substances added to foods to enhance aroma and taste. Spices have been reported to have health benefits as antioxidant, antibiotic, antiviral, anticoagulant, anticarcinogenic, and anti-inflammatory agents. Health claims about the benefits of condiments for disease prevention or health improvement need to be science based and extensively supported by evidence; data on their preventive or protective potential in humans are currently limited. The condiments market has been growing continuously over the last few years, with the quantity of products sold under the category of sauces, dressings, and condiments during the period 2008-2013 increasing from 31,749,000 to 35,795,000 metric tons. About 50 of the 86 spices produced in the world are grown in India. From 2008 to 2013, the United States was the largest importer of spices, followed by Australia, the United Kingdom, Canada, and Russia. The main buyers of fish sauce are Vietnam and Thailand, with purchases of 333,000 and 284,000 metric tons in 2013, respectively. The sauces and condiments category is dynamic, with large differences in consumption in habits and practices among countries. This paper aims to establish definitions and discuss potential health benefits, consumption patterns, and global markets for sauces, spices, and condiments.

  9. Concentration and potential health risk of heavy metals in market vegetables in Chongqing, China.

    PubMed

    Yang, Qing-Wei; Xu, Yuan; Liu, Shou-Jiang; He, Jin-Feng; Long, Fang-Yan

    2011-09-01

    Concentration and daily intake (DI) of heavy metals (Pb, Zn, Mn, Cu, Cd and Cr) in market vegetables in Chongqing of China are investigated and their potential health risk for local consumers is simultaneously evaluated by calculating the target hazard quotient (THQ). The results showed that the measured Pb and Cd concentrations exceeded the safety limits given by FAO/WHO and Chinese regulations, indicating serious contamination of market vegetables by these metals. As respective DI values for Pb, Mn and Cd were also above the international guideline bases, health risk to the consumers is obvious. The individual THQ for Pb and Cd in pakchoi and Cd in mustard, and the combined THQ for all metals in each vegetable species excluding cos lettuce were above the threshold 1.0, implying the obviously adverse effect on health. Therefore, attention should be paid particularly to the potential hazardous exposure to vegetable heavy metals, especially for Pb and Cd, over a lifetime for people in Chongqing.

  10. Market Potential Study for Standing Cabin Concept for Domestic Low-Cost Commercial Airlines in Malaysia

    NASA Astrophysics Data System (ADS)

    Romli, Fairuz I.; Dasuki, Norhafizah; Yazdi Harmin, Mohammad

    2016-02-01

    An affordable air transportation has become the operational aim of many airlines these days. This is to cater the growing air travel demands from people of different social and economic status. One of the revolutionary proposals to reduce the operational costs, hence the flight ticket price, is by introducing the so-called standing cabin concept. This concept involves transporting passengers during the entire flight in their standing position with a proper support of a vertical seat. As can be expected with many new inventions, despite its clear advantages, the concept has been met with mixed reactions from the public. This study intends to establish whether the standing cabin concept has a market potential to be implemented for domestic flights in Malaysia. The public perception is determined from collected data through a survey done at two major local low-cost airport terminals. It can be concluded from the results that the concept has a good market potential for application on flights with duration of less than two hours.

  11. Oil sands fine tailings - a resource material for potentially marketable products

    SciTech Connect

    Majid, A.; Sparks, B.D.; Coleman, R.D.

    1995-12-31

    Oil sands fine tailings is a complex mixture of components each having specific physical or chemical characteristics. Studies on the fundamental properties of fine tailings have resulted in the development of methods to fractionate the tailings into products with market potential. These include: bitumen, for production of synthetic crude oil or as an ancillary fuel; clean kaolin for fine paper coating; a gelling agent for drilling mud formulation; emulsifying solids, for surfactant replacement; and a mineral fraction, for heavy metal recovery. In this investigation we have attempted to evaluate the economic potential of fine tailings as a resource material by determining the amount and value of these products; the prime objective was to determine the economic feasibility of a tailings treatment scheme.

  12. Potential of size reduction of flat-plate solar collectors when applying MWCNT nanofluid

    NASA Astrophysics Data System (ADS)

    Faizal, M.; Saidur, R.; Mekhilef, S.

    2013-06-01

    Flat-plate solar collector is the most popular type of collector for hot water system to replace gas or electric heater. Solar thermal energy source is clean and infinite to replace fossil fuel source that is declining and harmful to the environment. However, current solar technology is still expensive, low in efficiency and takes up a lot of space. One effective way to increase the efficiency is by applying high conductivity fluid as nanofluid. This paper analyzes the potential of size reduction of solar collector when MWCNT nanofluid is used as absorbing medium. The analysis is based on different mass flow rate, nanoparticles mass fraction, and presence of surfactant in the fluid. For the same output temperature, it can be observed that the collector's size can be reduced up to 37% of its original size when applying MWCNT nanofluid as the working fluid and thus can reduce the overall cost of the system.

  13. One Size (Never) Fits All: Segment Differences Observed Following a School-Based Alcohol Social Marketing Program

    ERIC Educational Resources Information Center

    Dietrich, Timo; Rundle-Thiele, Sharyn; Leo, Cheryl; Connor, Jason

    2015-01-01

    Background: According to commercial marketing theory, a market orientation leads to improved performance. Drawing on the social marketing principles of segmentation and audience research, the current study seeks to identify segments to examine responses to a school-based alcohol social marketing program. Methods: A sample of 371 year 10 students…

  14. Size-dependent error of the density functional theory ionization potential in vacuum and solution

    DOE PAGES

    Sosa Vazquez, Xochitl A.; Isborn, Christine M.

    2015-12-22

    Density functional theory is often the method of choice for modeling the energetics of large molecules and including explicit solvation effects. It is preferable to use a method that treats systems of different sizes and with different amounts of explicit solvent on equal footing. However, recent work suggests that approximate density functional theory has a size-dependent error in the computation of the ionization potential. We here investigate the lack of size-intensivity of the ionization potential computed with approximate density functionals in vacuum and solution. We show that local and semi-local approximations to exchange do not yield a constant ionization potentialmore » for an increasing number of identical isolated molecules in vacuum. Instead, as the number of molecules increases, the total energy required to ionize the system decreases. Rather surprisingly, we find that this is still the case in solution, whether using a polarizable continuum model or with explicit solvent that breaks the degeneracy of each solute, and we find that explicit solvent in the calculation can exacerbate the size-dependent delocalization error. We demonstrate that increasing the amount of exact exchange changes the character of the polarization of the solvent molecules; for small amounts of exact exchange the solvent molecules contribute a fraction of their electron density to the ionized electron, but for larger amounts of exact exchange they properly polarize in response to the cationic solute. As a result, in vacuum and explicit solvent, the ionization potential can be made size-intensive by optimally tuning a long-range corrected hybrid functional.« less

  15. Melting line of the Lennard-Jones system, infinite size, and full potential.

    PubMed

    Mastny, Ethan A; de Pablo, Juan J

    2007-09-14

    Literature estimates of the melting curve of the Lennard-Jones system vary by as much as 10%. The origin of such discrepancies remains unclear. We present precise values for the Lennard-Jones melting temperature, and we examine possible sources of systematic errors in the prediction of melting points, including finite-size and interaction-cutoff effects. A hypothetical thermodynamic integration path is used to find the relative free energies of the solid and liquid phases, for various system sizes, at constant cutoff radius. The solid-liquid relative free energy and melting temperature scale linearly as the inverse of the number of particles, and it is shown that finite-size effects can account for deviations in the melting temperature (from the infinite-size limit) of up to 5%. An extended-ensemble density-of-states method is used to determine free energy changes for each phase as a continuous function of the cutoff radius. The resulting melting temperature predictions exhibit an oscillatory behavior as the cutoff radius is increased. Deviations in the melting temperature (from the full potential limit) arising from a finite cutoff radius are shown to be of comparable magnitude as those resulting from finite-size effects. This method is used to identify melting temperatures at five different pressures, for the infinite-size and full potential Lennard-Jones system. We use our simulation results as references to connect the Lennard-Jones solid equation of state of van der Hoef with the Lennard-Jones fluid equation of state of Johnson. Once the references are applied the two equations of state are used to identify a melting curve. An empirical equation that fits this melting curve is provided. We also report a reduced triple point temperature T(tr)=0.694.

  16. Estimating the transmission potential of supercritical processes based on the final size distribution of minor outbreaks.

    PubMed

    Nishiura, Hiroshi; Yan, Ping; Sleeman, Candace K; Mode, Charles J

    2012-02-07

    Use of the final size distribution of minor outbreaks for the estimation of the reproduction numbers of supercritical epidemic processes has yet to be considered. We used a branching process model to derive the final size distribution of minor outbreaks, assuming a reproduction number above unity, and applying the method to final size data for pneumonic plague. Pneumonic plague is a rare disease with only one documented major epidemic in a spatially limited setting. Because the final size distribution of a minor outbreak needs to be normalized by the probability of extinction, we assume that the dispersion parameter (k) of the negative-binomial offspring distribution is known, and examine the sensitivity of the reproduction number to variation in dispersion. Assuming a geometric offspring distribution with k=1, the reproduction number was estimated at 1.16 (95% confidence interval: 0.97-1.38). When less dispersed with k=2, the maximum likelihood estimate of the reproduction number was 1.14. These estimates agreed with those published from transmission network analysis, indicating that the human-to-human transmission potential of the pneumonic plague is not very high. Given only minor outbreaks, transmission potential is not sufficiently assessed by directly counting the number of offspring. Since the absence of a major epidemic does not guarantee a subcritical process, the proposed method allows us to conservatively regard epidemic data from minor outbreaks as supercritical, and yield estimates of threshold values above unity.

  17. Can inbound and domestic medical tourism improve your bottom line? Identifying the potential of a U.S. tourism market.

    PubMed

    Fottler, Myron D; Malvey, Donna; Asi, Yara; Kirchner, Sarah; Warren, Natalia A

    2014-01-01

    In large part due to current economic conditions and the political uncertainties of healthcare reform legislation, hospitals need to identify new sources of revenue. Two potentially untapped sources are inbound (international) and domestic (within the United States) medical tourists. This case study uses data from a large, urban healthcare system in the southeastern United States to quantify its potential market opportunities for medical tourism. The data were mined from electronic health records, and descriptive frequency analysis was used to provide a preliminary market assessment. This approach permits healthcare systems to move beyond anecdotal information and assess the relative market potential of their particular geographic area and the diagnostic services they offer for attracting inbound and domestic medical tourists. Implications for healthcare executives and guidance on how they can focus marketing efforts are discussed.

  18. Solar thermal technology development: Estimated market size and energy cost savings. Volume 1: Executive summary

    NASA Technical Reports Server (NTRS)

    Gates, W. R.

    1983-01-01

    Estimated future energy cost savings associated with the development of cost-competitive solar thermal technologies (STT) are discussed. Analysis is restricted to STT in electric applications for 16 high-insolation/high-energy-price states. The fuel price scenarios and three 1990 STT system costs are considered, reflecting uncertainty over future fuel prices and STT cost projections. STT R&D is found to be unacceptably risky for private industry in the absence of federal support. Energy cost savings were projected to range from $0 to $10 billion (1990 values in 1981 dollars), dependng on the system cost and fuel price scenario. Normal R&D investment risks are accentuated because the Organization of Petroleum Exporting Countries (OPEC) cartel can artificially manipulate oil prices and undercut growth of alternative energy sources. Federal participation in STT R&D to help capture the potential benefits of developing cost-competitive STT was found to be in the national interest.

  19. Solar thermal technology development: Estimated market size and energy cost savings. Volume 1: Executive summary

    NASA Astrophysics Data System (ADS)

    Gates, W. R.

    1983-02-01

    Estimated future energy cost savings associated with the development of cost-competitive solar thermal technologies (STT) are discussed. Analysis is restricted to STT in electric applications for 16 high-insolation/high-energy-price states. The fuel price scenarios and three 1990 STT system costs are considered, reflecting uncertainty over future fuel prices and STT cost projections. STT R&D is found to be unacceptably risky for private industry in the absence of federal support. Energy cost savings were projected to range from $0 to $10 billion (1990 values in 1981 dollars), dependng on the system cost and fuel price scenario. Normal R&D investment risks are accentuated because the Organization of Petroleum Exporting Countries (OPEC) cartel can artificially manipulate oil prices and undercut growth of alternative energy sources. Federal participation in STT R&D to help capture the potential benefits of developing cost-competitive STT was found to be in the national interest.

  20. Alumina at 50 and 13 nm nanoparticle sizes have potential genotoxicity.

    PubMed

    Zhang, Qinli; Wang, Haiyang; Ge, Cuicui; Duncan, Jeremy; He, Kaihong; Adeosun, Samuel O; Xi, Huaxin; Peng, Huiting; Niu, Qiao

    2017-03-24

    Although nanomaterials have the potential to improve human life, their sideline effects on human health seem to be inevitable and still are unknown. Some studies have investigated the genotoxicity of alumina nanoparticles (AlNPs); however, this effect is still unclear due to insufficient evaluation and conflicting results. Using a battery of standard genotoxic assays, the present study offers evidence of the genotoxicity associated with aluminum oxide (alumina) at NP sizes of 50 and 13 nm, when compared with bulk alumina (10 μm). The genotoxicity induced by alumina at bulk and NP sizes was evaluated with Ames test, comet test, micronucleus assay and sperm deformity test. The mechanism related to the induction of reactive oxygen species was explored as well. Our results showed that AlNPs (13 and 50 nm) were able to enter cells and induced DNA damage, micronucleus in bone marrow, sperm deformation and reactive oxygen species induction in a time-, dose- and size-dependent manner. Therefore, we conclude that AlNPs (13 and 50 nm), rather than bulk alumina, induce markers of genotoxicity in mice, with oxidative stress as a potential mechanism driving these genotoxic effects. Copyright © 2017 John Wiley & Sons, Ltd.

  1. Event-related potentials during word mapping to object shape predict toddlers' vocabulary size

    PubMed Central

    Borgström, Kristina; Torkildsen, Janne von Koss; Lindgren, Magnus

    2015-01-01

    What role does attention to different object properties play in early vocabulary development? This longitudinal study using event-related potentials in combination with behavioral measures investigated 20- and 24-month-olds' (n = 38; n = 34; overlapping n = 24) ability to use object shape and object part information in word-object mapping. The N400 component was used to measure semantic priming by images containing shape or detail information. At 20 months, the N400 to words primed by object shape varied in topography and amplitude depending on vocabulary size, and these differences predicted productive vocabulary size at 24 months. At 24 months, when most of the children had vocabularies of several hundred words, the relation between vocabulary size and the N400 effect in a shape context was weaker. Detached object parts did not function as word primes regardless of age or vocabulary size, although the part-objects were identified behaviorally. The behavioral measure, however, also showed relatively poor recognition of the part-objects compared to the shape-objects. These three findings provide new support for the link between shape recognition and early vocabulary development. PMID:25762957

  2. Six kilowatt, residential photovoltaic power systems study; design, performance, economics, market potential

    NASA Astrophysics Data System (ADS)

    Partain, L. D.

    1980-08-01

    A cost and performance analysis is presented for a solar cell electric system that can provide 70% of the electric power to a home in a California-like climate. Both a battery storage and no-storage configuration with a six kilowatt, peak power, solar array were considered, including batteries, for a 15 kWh per day average energy use that equals that of an average household in Northern California. For the promising, no-storage home system the uncertainties in important parameter values are too large to allow definitive assessment until better characterizations have been made. The political and policy decisions that can have a strong influence were assessed and quantified. The effects of tax credits, utility buyback, and proper home construction were considered. Potential markets in the hundreds of millions of dollars per year range that involve on the order of one million peak kilowatts of solar cells per year were estimated.

  3. International solar commercialization study of the market potential of solar products in Latin America: Jamaica. Final report

    SciTech Connect

    Not Available

    1981-12-01

    The current and forecasted economic situations in Jamaica are reviewed. The logistics of doing business is reviewed, including finance, labor, investment and import policy. Market penetration strategy is presented, with emphasis on the Kingston free zone analysis. A Market Potential for US Renewable Energy Products in Jamaica included government, agricultural, tourism, manufacturing, and mining sectors. Conclusions and recommendations are given. The market readiness of the following renewable technologies was analyzed: photovoltaics; industrial process heat; active and passive solar; biomass; wind; small-scale hydro; ocean thermal; geothermal; and conservation. When appropriate, the foreign competition was also analyzed.

  4. The potential for the introduction of the marketing concept into Australian public hospitals.

    PubMed

    Donnelly, J A

    1986-01-01

    Marketing theory and practice has gained broad acceptance in the business world generally. Of recent years, particularly in the United States, there have been increasing moves to incorporate marketing activities into the management of hospitals. In Australia there appears little empirical evidence in the literature to suggest a similar progression. This paper seeks to examine some of the essential ideas contained within the marketing concept and to expose the applicability of marketing to the efficient management of public hospitals.

  5. Size and shape dependent deprotonation potential and proton affinity of nanodiamond

    NASA Astrophysics Data System (ADS)

    Barnard, Amanda S.; Per, Manolo C.

    2014-11-01

    Many important reactions in biology and medicine involve proton abstraction and transfer, and it is integral to applications such as drug delivery. Unlike electrons, which are quantum mechanically delocalized, protons are instantaneously localized on specific residues in these reactions, which can be a distinct advantage. However, the introduction of nanoparticles, such as non-toxic nanodiamonds, to this field complicates matters, as the number of possible sites increases as the inverse radius of the particle. In this paper we present \\gt {{10}4} simulations that map the size- and shape-dependence of the deprotonation potential and proton affinity of nanodiamonds in the range 1.8-2.7 nm in average diameter. We find that while the average deprotonation potential and proton affinities decrease with size, the site-specific values are inhomogeneous over the surface of the particles, exhibiting strong shape-dependence. The proton affinity is strongly facet-dependent, whereas the deprotonation potential is edge/corner-dependent, which creates a type of spatial hysteresis in the transfer of protons to and from the nanodiamond, and provides new opportunities for selective functionalization.

  6. Surfactants, not size or zeta-potential influence blood-brain barrier passage of polymeric nanoparticles.

    PubMed

    Voigt, Nadine; Henrich-Noack, Petra; Kockentiedt, Sarah; Hintz, Werner; Tomas, Jürgen; Sabel, Bernhard A

    2014-05-01

    Nanoparticles (NP) can deliver drugs across the blood-brain barrier (BBB), but little is known which of the factors surfactant, size and zeta-potential are essential for allowing BBB passage. To this end we designed purpose-built fluorescent polybutylcyanoacrylate (PBCA) NP and imaged the NP's passage over the blood-retina barrier - which is a model of the BBB - in live animals. Rats received intravenous injections of fluorescent PBCA-NP fabricated by mini-emulsion polymerisation to obtain various NP's compositions that varied in surfactants (non-ionic, anionic, cationic), size (67-464nm) and zeta-potential. Real-time imaging of retinal blood vessels and retinal tissue was carried out with in vivo confocal neuroimaging (ICON) before, during and after NP's injection. Successful BBB passage with subsequent cellular labelling was achieved if NP were fabricated with non-ionic surfactants or cationic stabilizers but not when anionic compounds were added. NP's size and charge had no influence on BBB passage and cell labelling. This transport was not caused by an unspecific opening of the BBB because control experiments with injections of unlabelled NP and fluorescent dye (to test a "door-opener" effect) did not lead to parenchymal labelling. Thus, neither NP's size nor chemo-electric charge, but particle surface is the key factor determining BBB passage. This result has important implications for NP engineering in medicine: depending on the surfactant, NP can serve one of two opposite functions: while non-ionic tensides enhance brain up-take, addition of anionic tensides prevents it. NP can now be designed to specifically enhance drug delivery to the brain or, alternatively, to prevent brain penetration so to reduce unwanted psychoactive effects of drugs or prevent environmental nanoparticles from entering tissue of the central nervous system.

  7. THE CO2 ABATEMENT POTENTIAL OF CALIFORNIA'S MID-SIZED COMMERCIAL BUILDINGS

    SciTech Connect

    Stadler, Michael; Marnay, Chris; Cardoso, Goncalo; Lipman, Tim; Megel, Olivier; Ganguly, Srirupa; Siddiqui, Afzal; Lai, Judy

    2009-12-31

    The Ernest Orlando Lawrence Berkeley National Laboratory (LBNL) is working with the California Energy Commission (CEC) todetermine the potential role of commercial sector distributed generation (DG) with combined heat and power (CHP) capability deployment in greenhouse gas emissions (GHG) reductions. CHP applications at large industrial sites are well known, and a large share of their potential has already been harvested. In contrast, relatively little attention has been paid to the potential of medium-sized commercial buildings, i.e. ones with peak electric loads ranging from 100 kW to 5 MW. We examine how this sector might implement DG with CHP in cost minimizing microgrids that are able to adopt and operate various energy technologies, such as solar photovoltaics (PV), on-site thermal generation, heat exchangers, solar thermal collectors, absorption chillers, and storage systems. We apply a mixed-integer linear program (MILP) that minimizes a site?s annual energy costs as its objective. Using 138 representative mid-sized commercial sites in California (CA), existing tariffs of three major electricity distribution ultilities, and performance data of available technology in 2020, we find the GHG reduction potential for this CA commercial sector segment, which represents about 35percent of total statewide commercial sector sales. Under the assumptions made, in a reference case, this segment is estimated to be capable of economically installing 1.4 GW of CHP, 35percent of the California Air Resources Board (CARB) statewide 4 GW goal for total incremental CHP deployment by 2020. However, because CARB?s assumed utilization is far higher than is found by the MILP, the adopted CHP only contributes 19percent of the CO2 target. Several sensitivity runs were completed. One applies a simple feed-in tariff similar to net metering, and another includes a generous self-generation incentive program (SGIP) subsidy for fuel cells. The feed-in tariff proves ineffective at

  8. Market potential of electrolytic hydrogen production in three northeastern utilities' service territories. Final report

    SciTech Connect

    Fein, E.; Edwards, K.

    1984-05-01

    The study develops a method for exploring the market potential for electrolytic hydrogen. The service areas of three northeastern utilities - Public Service Electric and Gas, Niagara Mohawk, and Northeast Utilities - are examined, and results reported on the effort to locate specialty hydrogen users, determine patterns of hydrogen utilization, and assess the possibility of satisfying this hydrogen demand by electrolytic hydrogen from advanced electrolyzers. Hydrogen users were sought in six major product categories: chemicals, pharmaceuticals, oils, metals, electronics and float glass. Identification of users through appropriate standard industrial classification codes served as a basis for locating possible users in each of the service areas. Mailed questionnaires sought information on hydrogen demand, characteristics of hydrogen use, present hydrogen supply costs, and factors that would influence the purchase of an electrolyzer. In the three utility service areas examined, electrolytic hydrogen can be expected to have limited success competing with merchant hydrogen. Specific hydrogen users may be found whose location with respect to the source of merchant hydrogen may put electrolytic hydrogen at an economic advantage. Reduction in electrolyzer plant costs may be necessary to expand the possibilities for electrolysis. Annual power requirements for current potential demand for electrolytic hydrogen in three utilities was estimated at 140 x 10/sup 6/ kWh, which could expand to 240 x 10/sup 6/ kWh in ten years.

  9. Is there a potential consumer market for low-sodium fermented sausages?

    PubMed

    Dos Santos, Bibiana A; Campagnol, Paulo C B; da Cruz, Adriano G; Morgano, Marcelo A; Wagner, Roger; Pollonio, Marise A R

    2015-05-01

    The NaCl levels in dry fermented sausages were reduced by 50% or were substituted with KCl, CaCl2 , or a blend of KCl and CaCl2 (1:1). The quality, safety, and the potential consumer market of dry fermented sausages were assessed. Neither 50% reduction of the NaCl content nor the substitution of 50% of the NaCl with KCl influenced the fermentation and maturation process. However, when CaCl2 was used as the substitute salt (50%), there was a significant decrease in pH, an increase in the water activity, and a decrease in lactic acid and micrococcus bacterial counts. Overall, the sensory acceptance decreased in dry fermented sausages with reduced sodium content. However, cluster analysis and internal preference mapping revealed potential for commercialization of samples with 50% of the NaCl content substituted with KCl or with a mixture of KCl and CaCl2 (1:1).

  10. LUNAR DUST GRAIN CHARGING BY ELECTRON IMPACT: DEPENDENCE OF THE SURFACE POTENTIAL ON THE GRAIN SIZE

    SciTech Connect

    Nemecek, Z.; Pavlu, J.; Safrankova, J.; Beranek, M.; Richterova, I.; Vaverka, J.; Mann, I.

    2011-09-01

    The secondary electron emission is believed to play an important role for the dust charging at and close to the lunar surface. However, our knowledge of emission properties of the dust results from model calculations and rather rare laboratory investigations. The present paper reports laboratory measurements of the surface potential on Lunar Highlands Type regolith simulants with sizes between 0.3 and 3 {mu}m in an electron beam with energy below 700 eV. This investigation is focused on a low-energy part, i.e., {<=}100 eV. We found that the equilibrium surface potential of this simulant does not depend on the grain size in our ranges of grain dimensions and the beam energies, however, it is a function of the primary electron beam energy. The measurements are confirmed by the results of the simulation model of the secondary emission from the spherical samples. Finally, we compare our results with those obtained in laboratory experiments as well as those inferred from in situ observations.

  11. Production characteristics of body composition of Florida pompano reared to market size at two different densities in low salinity recirculating aquaculture systems

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The effect of culture density on production characteristics and body composition of Florida pompano Trachinotus carolinus reared to market size using recirculating aquaculture systems (RAS) at a salinity of 5 g/L was evaluated in a 110 day growth trial (water temperature, 27.0-28.5 C). Juvenile pom...

  12. Influence of the heteroatom size on the redox potentials of selected polyoxoanions.

    PubMed

    Mbomekallé, Israël-Martyr; López, Xavier; Poblet, Josep M; Sécheresse, Francis; Keita, Bineta; Nadjo, Louis

    2010-08-02

    The apparent formal potentials for the one-electron redox process of most Keggin-type heteropolytungstates, XW(12)O(40)(q-), have long been shown to linearly depend on their overall negative charges, in the absence of proton interference in the process. However, for a given overall negative charge, these formal potentials are also shown here to depend on the specific central heteroatom X. In the present work, cyclic voltammetry was used to study a large variety of Keggin-type anions, under conditions where their comparisons are straightforward. In short, apparent potential values get more negative (the clusters are more difficult to reduce) for smaller central heteroatoms within a given family of Keggin-type heteropolyanions carrying the same overall negative charge. Density functional theory calculations were performed on the same family of Keggin compounds and satisfactorily reproduce these trends. They show that internal XO(4) units affect differently the tungstate oxide cage. The electrostatic potential created by each internal anionic unit in a fragment-like approach (XO(4)(q-)@W(12)O(36)) was analyzed, and it is observed that X atoms of the same group show slight differences. Within each group of the periodic table, X atoms with lower atomic numbers are also smaller in size. The net effect of such a tendency is to produce a more negative potential in the surroundings and thus a smaller capacity to accept electrons. The case of [BW(12)O(40)](5-) illustrates well this conclusion, with the smallest heteroatom of the Keggin series with group III central elements and a very negative reduction potential with respect to the other elements of the same group. Particularly in this case, the electronic structure of the Keggin anion shows the effects of the small size of boron: the highest occupied molecular orbitals of [BW(12)O(40)](5-) appear to be approximately 0.35 eV higher than those in the other clusters of the same charge, explaining that the BO(4) unit is more

  13. Marketing to Older American Consumers.

    ERIC Educational Resources Information Center

    Mertz, Barbara; Stephens, Nancy

    1986-01-01

    Examined older adults as a potential market for American businesses. Data indicate that in terms of size and income, senior citizens comprise a substantial buying group. Their buying styles, product and service needs, and shopping behavior vary from younger adults and within the older adult population. Strategies for successful marketing are…

  14. The implications of potential `lock-in` markets for renewable energy

    SciTech Connect

    Cowan, R.; Kline, D.

    1996-11-01

    Nonlinear economic effects can cause unpredictable and sometimes undesirable outcomes in the marketplace. Increasing returns can lead to self-reinforcing situation in which increasing market share lead to a more attractive product, which leads in turn to further increases in market share. This results in ``lock-in`` of a technology, which cannot be overcome except by a significant shift in technology, consumer tastes, or other market factors.

  15. [The concept of social marketing--potential and limitations for health promotion and prevention in Germany].

    PubMed

    Loss, J; Lang, K; Ultsch, S; Eichhorn, C; Nagel, E

    2006-07-01

    "Social marketing" is the use of marketing principles to design and implement programmes to promote socially beneficial behaviour changes. In the field of health promotion and prevention, the systematic planning process of social marketing can offer new ideas and perspectives to the traditions of social science. Major characteristics of social marketing encompass continuous market research focussing on attitudes, motives and behavioural patterns of the target group, an integrated mix of strategic key elements, and the perpetual evaluation of all procedures. So far, however, it is unclear in how far social marketing is actually more effective than other concepts of programme planning. Furthermore, it has to be discussed whether the underlying philosophy of social marketing and its implicit understanding of relationships to the public are reconcilable with health promotion principles. In Anglo-Saxon countries, the social marketing concept has achieved widespread application and is subject to controversial scientific discussions, whereas this approach is hardly considered in German health promotion research and practice. Given the increasing call for quality management and evaluation of health promotion interventions, the social marketing concept may contribute useful insights at an operational level and thus add to a discussion on effective approaches for programme planning.

  16. Fabrication of large size graphene and Ti- MWCNTs/ large size graphene composites: their photocatalytic properties and potential application

    PubMed Central

    Ullah, Kefayat; Oh, Won-Chun

    2015-01-01

    Large size graphene (LSG) and multiwall carbon nanotubes (MWCNTs) on LSG were synthesized on a copper surface via chemical vapor deposition (CVD) at low temperature and normal pressure. The LSG were formed through an easy chemical cyclic reaction in which liquid benzene was heated to a temperature below its boiling point to create benzene vapors as graphene precursor material. The reaction mechanism was observed, and the time-dependent analysis of the reaction revealed that mounds of the carbon nanotubes had grown as a result of the island that was found on the LSG sheet. The implications of the mechanism that we have introduced were investigated by coating a titanium sheet on the MWCNTs/LSG and LSG on the semiconductor electronic device. The photonic response was observed to be markedly high, which can be attributed to the positive synergetic effect between the Ti and LSG sheet of our prepared composites. PMID:26384216

  17. Avian influenza viruses in Korean live poultry markets and their pathogenic potential.

    PubMed

    Choi, Young Ki; Seo, Sang Heui; Kim, Jin A; Webby, Richard J; Webster, Robert G

    2005-02-20

    We surveyed live-poultry markets in Korea in 2003 and isolated 9 H9N2, 6 H3N2, and 1 H6N1 influenza viruses. Antigenic and phylogenetic analyses showed that all 9 H9N2 isolates were of A/Chicken/Korea/25232-96006/96-like lineage (which caused disease in chickens in Korea in 1996) but were different from H9N2 viruses of southeastern China. They had at least 4 genotypes and replicated in chickens but not in mice. The H3N2 and H6N1 viruses were new to Korea and were probably reassortants of avian influenza viruses from southeastern China and recent Korean H9N2 viruses. All 8 segments of the H3N2 viruses formed a single phylogenetic cluster with 99.1 to 100% homology. The H3N2 viruses replicated in chickens and mice without preadaptation, but the H6N1 virus did not. Our results show an increasingly diverse pool of avian influenza viruses in Korea that are potential pandemic influenza agents.

  18. Energy conservation potential of Portland cement particle size distribution control, Phase 2

    SciTech Connect

    Helmuth, R.A; Whiting, D.A.

    1983-01-01

    The main objectives of Phase 2 are to determine the feasibility of using cements with controlled particle size distributions (CPSD cements) in practical concrete applications, and to refine our estimates of the potential energy savings that may ensue from such use. The work in Phase 2 is divided into two main tasks, some parts of which will be carried out simultaneously: Task 1 will continue cement paste studies to optimize cement performance similar to those of Phase 1, but with particular emphasis on gypsum requirements, blended cements, and water-reducing admixtures. This task will also include preparation of sufficient CPSD cements for use in all Phase 2 work. Task 2 will be a comprehensive examination of the properties of concretes made with CPSD cements. This will include optimization of concrete mix designs to obtain the best possible performance for practical applications of both portland and blended cements. The effects of chemical admixtures and curing temperature variations will also be determined.

  19. Evaluating the potential for stock size to limit recruitment in largemouth bass

    USGS Publications Warehouse

    Allen, Michael S.; Rogers, Mark W.; Catalano, Mathew J.; Gwinn, Daniel G.; Walsh, Stephen J.

    2011-01-01

    Compensatory changes in juvenile survival allow fish stocks to maintain relatively constant recruitment across a wide range of stock sizes (and levels of fishing), but few studies have experimentally explored recruitment compensation in fish populations. We evaluated the potential for recruitment compensation in largemouth bass Micropterus salmoides by stocking six 0.4-ha hatchery ponds with adult densities ranging from 6 to 40 fish over 2 years. Ponds were drained in October each year, and the age-0 fish densities were used as a measure of recruitment. We found no relationship between stock abundance and recruitment; ponds with low adult densities produced nearly as many recruits as the higher-density ponds in some cases. Both prey abundance and the growth of age-0 largemouth bass declined with age-0 fish density. Recruit abundance was highly variable both within and among the adult density groups, and thus we were unable to identify a clear stock–recruit relationship for largemouth bass. Our results indicate that reducing the number of effective spawners via angling practices would not reduce recruitment over a relatively large range in stock size.

  20. Addressing vaccine hesitancy: The potential value of commercial and social marketing principles and practices.

    PubMed

    Nowak, Glen J; Gellin, Bruce G; MacDonald, Noni E; Butler, Robb

    2015-08-14

    Many countries and communities are dealing with groups and growing numbers of individuals who are delaying or refusing recommended vaccinations for themselves or their children. This has created a need for immunization programs to find approaches and strategies to address vaccine hesitancy. An important source of useful approaches and strategies is found in the frameworks, practices, and principles used by commercial and social marketers, many of which have been used by immunization programs. This review examines how social and commercial marketing principles and practices can be used to help address vaccine hesitancy. It provides an introduction to key marketing and social marketing concepts, identifies some of the major challenges to applying commercial and social marketing approaches to immunization programs, illustrates how immunization advocates and programs can use marketing and social marketing approaches to address vaccine hesitancy, and identifies some of the lessons that commercial and non-immunization sectors have learned that may have relevance for immunization. While the use of commercial and social marketing practices and principles does not guarantee success, the evidence, lessons learned, and applications to date indicate that they have considerable value in fostering vaccine acceptance.

  1. Shared Solar: Current Landscape, Market Potential, and the Impact of Federal Securities Regulation; NREL (National Renewable Energy Laboratory)

    SciTech Connect

    2015-05-27

    This presentation provides a high-level overview of the current U.S. shared solar landscape, the impact that a given shared solar program's structure has on requiring federal securities oversight, as well as an estimate of market potential for U.S. shared solar deployment.

  2. Web Based Interactive Software in International Business: The Case of the Global Market Potential System Online (GMPSO[C])

    ERIC Educational Resources Information Center

    Janavaras, Basil J.; Gomes, Emanuel; Young, Richard

    2008-01-01

    This paper seeks to confirm whether students using the Global Market Potential System Online (GMPSO) web based software, (http://globalmarketpotential.com), for their class project enhanced their knowledge and understanding of international business. The challenge most business instructors and practitioners face is to determine how to bring the…

  3. [Post-marketing reevaluation for potential quality risk and quality control in clinical application of traditional Chinese medicines].

    PubMed

    Li, Hong-jiao; He, Li-yun; Liu, Bao-yan

    2015-06-01

    The effective quality control in clinical practices is an effective guarantee for the authenticity and scientificity of the findings. The post-marketing reevaluation for traditional Chinese medicines (TCM) focuses on the efficacy, adverse reaction, combined medication and effective dose of drugs in the market by expanded clinical trials, and requires a larger sample size and a wider range of patients. Therefore, this increases the difficulty of quality control in clinical practices. With the experience in quality control in clinical practices for the post-marketing reevaluation for Kangbingdu oral for cold, researchers in this study reviewed the study purpose, project, scheme design and clinical practice process from an overall point of view, analyzed the study characteristics of the post-marketing reevaluation for TCMs and the quality control risks, designed the quality control contents with quality impacting factors, defined key review contents and summarized the precautions in clinical practices, with the aim to improve the efficiency of quality control of clinical practices. This study can provide reference to clinical units and quality control-related personnel in the post-marketing reevaluation for TCMs.

  4. Low-Carbon Natural Gas for Transportation: Well-to-Wheels Emissions and Potential Market Assessment in California

    SciTech Connect

    Penev, Michael; Melaina, Marc; Bush, Brian; Muratori, Matteo; Warner, Ethan; Chen, Yuche

    2016-12-01

    This report improves on the understanding of the long-term technology potential of low-carbon natural gas (LCNG) supply pathways by exploring transportation market adoption potential through 2035 in California. Techno-economic assessments of each pathway are developed to compare the capacity, cost, and greenhouse gas (GHG) emissions of select LCNG production pathways. The study analyzes the use of fuel from these pathways in light-, medium-, and heavy-duty vehicle applications. Economic and life-cycle GHG emissions analysis suggest that landfill gas resources are an attractive and relatively abundant resource in terms of cost and GHG reduction potential, followed by waste water treatment plants and biomass with gasification and methanation. Total LCNG production potential is on the order of total natural gas demand anticipated in a success scenario for future natural gas vehicle adoption by 2035 across light-, medium-, and heavy-duty vehicle markets (110 trillion Btu/year).

  5. Osteogenic potential of murine periosteum for critical-size cranial defects.

    PubMed

    Ruvalcaba-Paredes, E K; Hidalgo-Bastida, L A; Sesman-Bernal, A L; Garciadiego-Cazares, D; Pérez-Dosal, M R; Martínez-López, V; Vargas-Sandoval, B; Pichardo-Bahena, R; Ibarra, C; Velasquillo, C

    2016-09-01

    Tissue engineering of bone has combined bespoke scaffolds and osteoinductive factors to maintain functional osteoprogenitor cells, and the periosteum has been confirmed as a satisfactory source of osteoblasts. Suitable matrices have been identified that support cell proliferation and differentiation, including demineralised bone matrix (both compatible and osteoinductive) and acellular human dermis. We have evaluated the osteogenic potential of an osteogenic unit, developed by combining periosteum, demineralised bone matrix, and acellular human dermis, in rodents with critical-size cranial defects. Briefly, remnants from the superior maxillary periosteum were used to harvest cells, which were characterised by flow cytometry and reverse retrotranscriptase-polymerase chain reaction (RT-PCR). Cells were cultured into the osteogenic unit and assessed for viability before being implanted into 3 rodents, These were compared with the control group (n=3) after three months. Histological analyses were made after staining with haematoxylin and eosin and Von Kossa, and immunostaining, and confirmed viable cells that stained for CD90, CD73, CD166, runt-related transcription factor, osteopontin, and collagen type I in the experimental group, while in the control group there was only connective tissue on the edges of the bone in the injury zone. We conclude that osteogenic unit constructs have the osteogenic and regenerative potential for use in engineering bone tissue.

  6. Body size, nuptial pad size and hormone levels: potential non-destructive biomarkers of reproductive health in wild toads (Bufo bufo).

    PubMed

    Orton, Frances; Baynes, Alice; Clare, Frances; Duffus, Amanda L J; Larroze, Severine; Scholze, Martin; Garner, Trenton W J

    2014-09-01

    Amphibians are declining and fertility/fecundity are major drivers of population stability. The development of non-destructive methods to assess reproductive health are needed as destructive measures are fundamentally at odds with conservation goals for declining species. We investigated the utility of body size, nuptial pad size and forelimb width as non-destructive biomarkers of internal reproductive physiology, by analysing correlations with commonly used destructive methods in adult male toads (Bufo bufo) from a low human impact and a high human impact site. Principal component analyses revealed that size was the most important variable for explaining inter-individual differences in other measured endpoints, both non-destructive and destructive, except for hormone levels and nuptial pad, which were independent of size. Toads from the LI and the HI site differed in almost all of the measured endpoints; this was largely driven by the significantly smaller size of toads from the HI site. Correlational analyses within sites revealed that size was correlated with several reproductive endpoints in toads from the HI site but not the LI site, indicating a possible limiting effect of size on reproductive physiology. Intersex was observed in 33% of toads from the HI site and incidence was not related to any other measured endpoint. In conclusion, we provide evidence that size is associated with reproductive physiology and that nuptial pad/hormone levels have potential as additional markers due to their independence from size. We also show that human activities can have a negative effect on reproductive physiology of the common toad.

  7. Advanced Sensors and Controls for Building Applications: Market Assessment and Potential R&D Pathways

    SciTech Connect

    Brambley, M. R.; Haves, P.; McDonald, S. C.; Torcellini, P.; Hansen, D.; Holmberg, D. R.; Roth, K. W.

    2005-04-01

    This document provides a market assessment of existing building sensors and controls and presents a range of technology pathways (R&D options) for pursuing advanced sensors and building control strategies.

  8. Potential of the tractor-trailer and container segments as entry markets for a proposed refrigeration technology

    SciTech Connect

    Smith, S.A.; Davis, L.J.; Garrett, B.A.

    1987-05-01

    The refrigerated trailer and container segments of the transportation industry are evaluated as potential entry markets for a proposed absorption refrigeration technology. To perform this analysis the existing transportation refrigeration industry is characterized; this includes a description of the current refrigeration technology, rating systems, equipment manufacturers, maintenance requirements, and sales trends. This information indicates that the current transportation refrigeration industry is composed of two major competitors, Thermo King and Carrier. In addition, it has low profit potential, some barriers to entry and low growth potential. Data are also presented that characterize the transportation refrigeration consumers, specifically, major groups, market segmentation, consumer decision process, and buying criteria. This consumer information indicates that the majority of refrigerated trailer consumers are private carriers, and that the majority of refrigerated container consumers are shipping companies. Also, these consumers are primarily interested in buying reliable equipment at a low price, and are quite satisfied with existing refrigeration equipment.

  9. Relationship Between Aerosol Number Size Distribution and Atmospheric Electric Potential Gradient in an Urban Area

    NASA Astrophysics Data System (ADS)

    Wright, Matthew; Matthews, James; Bacak, Asan; Silva, Hugo; Priestley, Michael; Percival, Carl; Shallcross, Dudley

    2016-04-01

    Small ions are created in the atmosphere by ground based radioactive decay and solar and cosmic radiation ionising the air. The ionosphere is maintained at a high potential relative to the Earth due to global thunderstorm activity, a current from the ionosphere transfers charge back to the ground through the weakly ionised atmosphere. A potential gradient (PG) exists between the ionosphere and the ground that can be measured in fair weather using devices such as an electric field mill. PG is inversely-proportional to the conductivity of the air and therefore to the number of ions of a given electrical mobility; a reduction of air ions will cause an increase of PG. Aerosols in the atmosphere act as a sink of air ions with an attachment rate dependent on aerosol size distribution and ion mobility. These relationships have been used to infer high particulate, and hence pollution, levels in historic datasets of atmospheric PG. A measurement campaign was undertaken in Manchester, UK for three weeks in July and August where atmospheric PG was measured with an electric field mill (JCI131, JCI Chilworth) on a second floor balcony, aerosol size distribution measured with a scanning mobility particle sizer (SMPS, TSI3936), aerosol concentration measured with a condensation particle counter (CPC, Grimm 5.403) and local meteorological measurements taken on a rooftop measurement site ~200 m away. Field mill and CPC data were taken at 1 s intervals and SMPS data in 2.5 minute cycles. Data were excluded for one hour either side of rainfall as rainclouds and droplets can carry significant charge which would affect PG. A quantity relating to the attachment of ions to aerosol (Ion Sink) was derived from the effective attachment coefficient of the aerosols. Further measurements with the field mill and CPC were taken at the same location in November 2015 when bonfire events would be expected to increase aerosol concentrations. During the summer measurements, particle number count (PNC

  10. Agri-Environmental Policy Measures in Israel: The Potential of Using Market-Oriented Instruments

    NASA Astrophysics Data System (ADS)

    Amdur, Liron; Bertke, Elke; Freese, Jan; Marggraf, Rainer

    2011-05-01

    This paper examines the possibilities of developing agri-environmental policy measures in Israel, focusing on market-oriented instruments. A conceptual framework for developing agri-environmental policy measures is presented, first in very broad lines (mandatory regulations, economic instruments and advisory measures) and subsequently focusing on economic instruments, and specifically, on market-oriented ones. Two criteria of choice between the measures are suggested: their contribution to improving the effectiveness of the policy; and the feasibility of their implementation. This is the framework used for analyzing agri-environmental measures in Israel. Israel currently implements a mix of mandatory regulations, economic instruments and advisory measures to promote the agri-environment. The use of additional economic instruments may improve the effectiveness of the policy. When comparing the effectiveness of various economic measures, we found that the feasibility of implementation of market-oriented instruments is greater, due to the Israeli public's preference for strengthening market orientation in the agricultural sector. Four market-oriented instruments were practiced in a pilot project conducted in an Israeli rural area. We found that in this case study, the institutional feasibility and acceptance by stakeholders were the major parameters influencing the implementation of the market-oriented instruments, whereas the instruments' contribution to enhancing the ecological or economic effectiveness were hardly considered by the stakeholders as arguments in favor of their use.

  11. Agri-environmental policy measures in Israel: the potential of using market-oriented instruments.

    PubMed

    Amdur, Liron; Bertke, Elke; Freese, Jan; Marggraf, Rainer

    2011-05-01

    This paper examines the possibilities of developing agri-environmental policy measures in Israel, focusing on market-oriented instruments. A conceptual framework for developing agri-environmental policy measures is presented, first in very broad lines (mandatory regulations, economic instruments and advisory measures) and subsequently focusing on economic instruments, and specifically, on market-oriented ones. Two criteria of choice between the measures are suggested: their contribution to improving the effectiveness of the policy; and the feasibility of their implementation. This is the framework used for analyzing agri-environmental measures in Israel. Israel currently implements a mix of mandatory regulations, economic instruments and advisory measures to promote the agri-environment. The use of additional economic instruments may improve the effectiveness of the policy. When comparing the effectiveness of various economic measures, we found that the feasibility of implementation of market-oriented instruments is greater, due to the Israeli public's preference for strengthening market orientation in the agricultural sector. Four market-oriented instruments were practiced in a pilot project conducted in an Israeli rural area. We found that in this case study, the institutional feasibility and acceptance by stakeholders were the major parameters influencing the implementation of the market-oriented instruments, whereas the instruments' contribution to enhancing the ecological or economic effectiveness were hardly considered by the stakeholders as arguments in favor of their use.

  12. Literature review and summary of perceptions, attitudes, beliefs, and marketing of potentially reduced exposure products: communication implications.

    PubMed

    Pederson, Linda L; Nelson, David E

    2007-05-01

    Potentially reduced exposure products (PREPs) have continued to enter the market during the 1990s and first part of the 21st century. Attempts by the tobacco industry to develop and market products with implied reductions in adverse health effects (i.e., harm reduction) are not new. Over the last half of the 20th century, the tobacco industry developed and marketed several products that purported to reduce the health risks associated with smoking cigarettes. Among these were filtered cigarettes in the 1950s and light and ultra-light cigarettes in the 1970s and 1980s. This review summarizes published and unpublished research that is directly relevant to the marketing, advertising, and communication about PREPs. The marketing strategies for these new products do not appear to differ from those used by the tobacco industry for light and ultra-light cigarettes. Although smokers report not using the new products in large numbers because of dissatisfaction with taste, they are interested in using products with reduced risk. Despite the absence of explicit health claims by the industry for PREPs, many smokers believe that these products are safer based on the advertising claims of reduced exposure and a belief that claims are approved by the government. No data are available to indicate that PREPs are useful for prevention or cessation of smoking, nor does specific research exist to suggest what health communication messages will provide smokers with accurate information about these products.

  13. The Potential for Accurately Measuring Behavioral and Economic Dimensions of Consumption, Prices, and Markets for Illegal Drugs

    PubMed Central

    Johnson, Bruce D.; Golub, Andrew

    2007-01-01

    There are numerous analytic and methodological limitations to current measures of drug market activity. This paper explores the structure of markets and individual user behavior to provide an integrated understanding of behavioral and economic (and market) aspects of illegal drug use with an aim toward developing improved procedures for measurement. This involves understanding the social processes that structure illegal distribution networks and drug users’ interactions with them. These networks are where and how social behaviors, prices, and markets for illegal drugs intersect. Our focus is upon getting an up close measurement of these activities. Building better measures of consumption behaviors necessitates building better rapport with subjects than typically achieved with one-time surveys in order to overcome withholding and underreporting and to get a comprehensive understanding of the processes involved. This can be achieved through repeated interviews and observations of behaviors. This paper also describes analytic advances that could be adopted to direct this inquiry including behavioral templates, and insights into the economic valuation of labor inputs and cash expenditures for various illegal drugs. Additionally, the paper makes recommendations to funding organizations for developing the mechanisms that would support behavioral scientists to weigh specimens and to collect small samples for laboratory analysis—by providing protection from the potential for arrest. The primary focus is upon U.S. markets. The implications for other countries are discussed. PMID:16978801

  14. Magnetic Grain-size Proxies in Loessic Soils and Their Potential use in Paleorainfall Reconstruction

    NASA Astrophysics Data System (ADS)

    Machac, T. A.; Geiss, C. E.; Zanner, C. W.

    2005-05-01

    As part of our ongoing rock-magnetic study of loessic soil profiles we sampled over 70 in Nebraska, Iowa, Missouri and Illinois. Our sampling sites are located in stable upland positions and extend along a rainfall gradient which ranges from an average annual precipitation of less than 500 mm/year in southwestern Nebraska to almost 1000 mm/year in central Missouri. Soil cores were obtained with the aid of a hydraulic soil probe, described and subsampled into small plastic bags. Samples were air-dried in the laboratory and the < 2mm fraction was used for magnetic analyses. We measured magnetic susceptibility X and several remanence parameters (ARM, IRM) for all samples. Hysteresis measurements, IRM acquisition curves and time dependence of IRM acquisition were measured for a subset of samples. All samples show magnetically enhanced A- and B-horizons, which results in increased values of X, ARM and IRM. Changes in the ratio of ARM/IRM suggest an increase in the relative abundance of stable single domain (SSD) particles. VRM analyses show that the upper soil horizons are enhanced in ultrafine superparamagnetic (SP) ferrimagnets as well. Changes in the relative abundance of SP and SSD ferrimagnets along our transsect correlates well with the modern precipitation gradient, suggesting the use of grain-size dependent magnetic parameter as a potential paleorainfall proxy when analyzing paleosols.

  15. Self-insurance and the potential effects of health reform on the small-group market.

    PubMed

    Linehan, Kathryn

    2010-12-21

    The Patient Protection and Affordable Care Act (PPACA) as amended by the Health Care Education Reconciliation Act of 2010 makes landmark changes to health insurance markets. Individual and small-group insurance plans and markets will see the biggest changes, but PPACA also affects large employer and self-insured plans by imposing rules for benefit design and health plan practices. Over half of workers--most often those in very large firms--are covered by self-insured health plans in which employers (or employee groups) bear all or some of the risk of providing insurance coverage to a defined population of workers and their dependents. As PPACA provisions become effective, some have argued that smaller firms that offer insurance may opt to self-insure their health benefits because of new small-group market rules. Such a shift could affect risk pooling in the small-group market. This paper examines the definition and prevalence of self-insured health plans, the application of PPACA provisions to these plans, and the possible effects on the broader health insurance market, should many more employers decide to self-insure.

  16. Using Market Research to Characterize College Students and Identify Potential Targets for Influencing Health Behaviors.

    PubMed

    Berg, Carla J; Ling, Pamela M; Guo, Hongfei; Windle, Michael; Thomas, Janet L; Ahluwalia, Jasjit S; An, Lawrence C

    2010-12-01

    Marketing campaigns, such as those developed by the tobacco industry, are based on market research, which defines segments of a population by assessing psychographic characteristics (i.e., attitudes, interests). This study uses a similar approach to define market segments of college smokers, to examine differences in their health behaviors (smoking, drinking, binge drinking, exercise, diet), and to determine the validity of these segments. A total of 2,265 undergraduate students aged 18-25 years completed a 108-item online survey in fall 2008 assessing demographic, psychographic (i.e., attitudes, interests), and health-related variables. Among the 753 students reporting past 30-day smoking, cluster analysis was conducted using 21 psychographic questions and identified three market segments - Stoic Individualists, Responsible Traditionalists, and Thrill-Seeking Socializers. We found that segment membership was related to frequency of alcohol use, binge drinking, and limiting dietary fat. We then developed three messages targeting each segment and conducted message testing to validate the segments on a subset of 73 smokers representing each segment in spring 2009. As hypothesized, each segment indicated greater relevance and salience for their respective message. These findings indicate that identifying qualitatively different subgroups of young adults through market research may inform the development of engaging interventions and health campaigns targeting college students.

  17. Maximizing the existing potential of new foreign markets for anthracite: Executive summary

    SciTech Connect

    Ziolkowski, L.W.; Ahn, Y.K.; Hong, S.P.

    1988-09-01

    The major purposes of this report were to: (1) conduct an in-depth survey of both the technical and marketing problems in the United States Anthracite Industry (predominately in Northeastern Pennsylvania); and (2) make recommendations in areas of technical R and D needs that will enhance the United States export of anthracite to foreign markets (especially Korea). Furthermore, the report identifies various anthracite culm drying and other coal utilization concepts; recommends several anthracite utilization configurations which appear to be the most suitable to the Korean market and a sensitivity analysis on these configurations; and identifies several solutions to resolve some of the problems which were identified relative to: (a) reducing the price of exporting anthracite; (b) the producers quality control activities which relate to meeting the Korean specifications and generally improving the understanding on the contract terms that relate to the encouragement of long term commitments of anthracite by Korea. 5 figs., 11 tabs.

  18. AgSTAR Market Opportunities Report

    EPA Pesticide Factsheets

    Assesses the market potential for biogas energy projects at swine and dairy farms in the United States and characterizes the sizes and types of operations where biogas projects are technically feasible.

  19. Assessing Market Potential in the Inquiry Pool. AIR Forum 1982 Paper.

    ERIC Educational Resources Information Center

    Lay, Robert; And Others

    The inquiry pool represented by prospective college applicants who seek information from the institution and a marketing response that has been implemented at Boston College are considered. It is suggested that researchers may trace specific individuals from the inquiry stage through application to the final college choice. To benefit from an…

  20. Only in Canada: A Study of National Market Potential for Christian Higher Education Canada (CHEC) Institutions

    ERIC Educational Resources Information Center

    Hiebert, Al

    2011-01-01

    In July 2007 Ipsos Reid delivered to Christian Higher Education Canada (CHEC) a report entitled "Christian Post-Secondary Education in Canada, Phase 3: Defining the Market". This article is a selective summary of the full 353-page report. It tabulates and analyzes findings from 1,000 phone interviews and 6,689 online surveys from six…

  1. The Potential for Renewable Energy Development to Benefit Restoration of the Salton Sea. Analysis of Technical and Market Potential

    SciTech Connect

    Gagne, Douglas; Haase, Scott; Oakleaf, Brett; Hurlbut, David; Akar, Sertac; Wall, Anna; Turchi, Craig; Pienkos, Philip; Melius, Jennifer; Melaina, Marc

    2015-11-01

    This report summarizes the potential for renewable energy development in the Salton Sea region, as well as the potential for revenues from this development to contribute financially to Salton Sea restoration costs. It considers solar, geothermal, biofuels or nutraceutical production from algae pond cultivation, desalination using renewable energy, and mineral recovery from geothermal fluids.


  2. Future Potential of Hybrid and Diesel Powertrains in the U.S. Light-duty Vehicle Market

    SciTech Connect

    Greene, D.L.

    2004-08-23

    Diesel and hybrid technologies each have the potential to increase light-duty vehicle fuel economy by a third or more without loss of performance, yet these technologies have typically been excluded from technical assessments of fuel economy potential on the grounds that hybrids are too expensive and diesels cannot meet Tier 2 emissions standards. Recently, hybrid costs have come down and the few hybrid makes available are selling well. Diesels have made great strides in reducing particulate and nitrogen oxide emissions, and are likely though not certain to meet future standards. In light of these developments, this study takes a detailed look at the market potential of these two powertrain technologies and their possible impacts on light-duty vehicle fuel economy. A nested multinomial logit model of vehicle choice was calibrated to 2002 model year sales of 930 makes, models and engine-transmission configurations. Based on an assessment of the status and outlook for the two technologies, market shares were predicted for 2008, 2012 and beyond, assuming no additional increase in fuel economy standards or other new policy initiatives. Current tax incentives for hybrids are assumed to be phased out by 2008. Given announced and likely introductions by 2008, hybrids could capture 4-7% and diesels 2-4% of the light-duty market. Based on our best guesses for further introductions, these shares could increase to 10-15% for hybrids and 4-7% for diesels by 2012. The resulting impacts on fleet average fuel economy would be about +2% in 2008 and +4% in 2012. If diesels and hybrids were widely available across vehicle classes, makes, and models, they could capture 40% or more of the light-duty vehicle market.

  3. Marketing 101.

    ERIC Educational Resources Information Center

    Henderson, Karla A.

    1997-01-01

    A marketing model for camps includes a mix of services, presentation, and communication elements that promote the virtues of camp, convince potential campers and their families of the benefits of camp, and successfully distinguish the camp from others. Includes resources related to marketing strategies, theme merchandise, and market trends…

  4. An observational study of retail availability and in-store marketing of e-cigarettes in London: potential to undermine recent tobacco control gains?

    PubMed Central

    Hsu, Robert; Myers, Allison E; Ribisl, Kurt M; Marteau, Theresa M

    2013-01-01

    Objectives E-cigarette companies and vendors claim the potential of e-cigarettes to help smokers reduce or quit tobacco use. E-cigarettes also have the potential to renormalise smoking. The purpose of this study was to describe the availability and in-store marketing of e-cigarettes in London, UK stores selling tobacco and alcohol. Design Observational study. Setting Small and large stores selling alcohol and tobacco in London, UK. Primary and secondary outcome measures The number of stores selling e-cigarettes, the number of stores with an interior or exterior e-cigarette advertisement, the number of stores with an e-cigarette point-of-sale movable display, store size, deprivation index score for store's corresponding lower super output area. Results Audits were completed in 108 of 128 selected stores. 62 of the audited stores (57%) sold e-cigarettes. E-cigarette availability was unrelated to store size. There was a statistically non-significant trend towards increased availability in more deprived areas (p=0.069). 31 of the 62 stores (50%) selling e-cigarettes had a point-of-sale movable display, with all but one found in small stores. Two small stores had interior advertisements and eight had exterior advertisements. No advertisements were observed in large stores. Conclusions This audit revealed widespread availability of e-cigarettes and in-store marketing in London, UK. Even if e-cigarettes prove to be an effective cessation aid, their sale and use are resulting in an increasing public presence of cigarette-like images and smoking behaviour. After decades of work to denormalise smoking, these findings raise the question of whether e-cigarettes are renormalising smoking. PMID:24366581

  5. Influences of filler content and size on the color adjustment potential of nonlayered resin composites.

    PubMed

    Suh, Yong-Rok; Ahn, Jin-Soo; Ju, Sung-Won; Kim, Kwang-Mahn

    2017-01-31

    The blending effect (BE) plays an important role in esthetics of the composite resin. The objective of this study was to determine the extents to which filler size and content affect the BE. Three types of fillers (0.7, 1.0, and 1.5 µm) were mixed at weight contents of 60, 70, 75, and 80%. This study simulated clinical class 3 or 4 cavities and quantitatively measured the color diffusion of the objects next to the cavities based on the CIELab color space. For each filler size, there was a trend of increasing BE as the filler content was increased. The translucency parameter (TP) exhibited the opposite trend of decreasing (p<0.05) with increases in filler content. The filler size did not affect the BE, and the different filler sizes produced statistically non-significant results in this study. Increases in filler content elevated the opacity of the composite resin and significantly influenced the BE.

  6. Estimating Demand Response Market Potential Among Large Commercialand Industrial Customers:A Scoping Study

    SciTech Connect

    Goldman, Charles; Hopper, Nicole; Bharvirkar, Ranjit; Neenan,Bernie; Cappers, Peter

    2007-01-01

    Demand response is increasingly recognized as an essentialingredient to well functioning electricity markets. This growingconsensus was formalized in the Energy Policy Act of 2005 (EPACT), whichestablished demand response as an official policy of the U.S. government,and directed states (and their electric utilities) to considerimplementing demand response, with a particular focus on "price-based"mechanisms. The resulting deliberations, along with a variety of stateand regional demand response initiatives, are raising important policyquestions: for example, How much demand response is enough? How much isavailable? From what sources? At what cost? The purpose of this scopingstudy is to examine analytical techniques and data sources to supportdemand response market assessments that can, in turn, answer the secondand third of these questions. We focus on demand response for large(>350 kW), commercial and industrial (C&I) customers, althoughmany of the concepts could equally be applied to similar programs andtariffs for small commercial and residential customers.

  7. The legalization of cannabis derivatives in Spain: Hypothesis on a potential emerging market.

    PubMed

    Álvarez, Arturo; Gamella, Juan F; Parra, Iván

    2016-10-07

    First, this paper estimates the dimensions of the market for cannabis in Spain using data on the extent of consumption and the main patterns of use of consumers. Then the paper reviews the hypothetical production and distribution costs of these drugs in different production regimes under different legal conditions. The review shows that current prices of cannabis in the illegal market could be notably reduced if production and distribution of cannabis were decriminalized and even more if they were performed by legal enterprises. Thirdly, we examine the relationship between prices and consumption levels by analysing the price elasticity of demand. A fall in the prices of cannabis products will likely result in an increase in the number of users and in the total amount consumed. Lastly we consider several alternatives for the taxation of cannabis derivatives to counteract the likely fall in prices, and their pros and cons.

  8. Economic potential of market-oriented water storage decisions: Evidence from Australia

    NASA Astrophysics Data System (ADS)

    Brennan, Donna

    2010-08-01

    Significant reforms made to Australian irrigation property rights in recent years have enabled the development of an active seasonal water market. In contrast, decisions regarding the allocation of water across time are typically based on central decisions, with little or no opportunity offered to irrigators to manage risk by physically transferring their water access right between years by leaving it in the public dam. An empirical examination of the economics of water storage is presented using a case study of the Goulburn Valley, a major irrigation region in the state of Victoria. It is shown that, compared to the historically used, centrally determined storage policy, a market-based storage policy would store more water, on average, and would also allocate more water in periods of low rainfall. The analysis indicates that the costs associated with a recent prolonged drought were $100 million more than they would have been if water storage decisions had been guided by the market and prices were 3 times higher.

  9. The importance of the measurement of ATP depletion and subsequent cell damage with an estimate of size and nature of the market for a practicable method: a review designed for technology transfer.

    PubMed

    Harkness, R A; Saugstad, O D

    1997-12-01

    ATP is the energy currency of cells. ATP depletion is a central process in pathogenesis, in particular ischaemia, hypoxia and hypoglycaemia. ATP depletion in cells can be indirectly measured from the increased concentrations of extracellular hypoxanthine, a central intermediate in the metabolism of ATP. Cell damage secondary to ATP depletion can also be measured from extracellular hypoxanthine. The relevant biochemistry and physiology is briefly reviewed. Since market size is needed for investment decisions that would allow technology transfer, the numbers of hypoxanthine analyses that are clinically justified from the extensive published evidence are calculated per million population from UK, Norwegian and other evidence. The concentration of oxygen in blood is measured to estimate whether mitochondrial oxidative phosphorylation is adequate. Measurements of bicarbonate are used to estimate anaerobic glycolysis. Since the indirect estimation of ATP depletion is a major objective of blood gas and acid-base analyses, the number of such analyses per million population provides a good estimate of potential market size for a more direct method of estimating ATP depletion. A method is required for the rapid, dispersed emergency analyses needed clinically. Routes for method development are indicated. Competition, risks, acceptability, consumer motivation and timetables are indicated for the development phase. There are medicolegal pressures, especially in the USA, for the proposed advances to be widely used.

  10. Parametric study of potential early commercial MHD power plants. Task 3: Parameter variation of plant size

    NASA Technical Reports Server (NTRS)

    Hals, F. A.

    1981-01-01

    Plants with a nominal output of 200 and 500 MWe and conforming to the same design configuration as the Task II plant were investigated. This information is intended to permit an assessment of the competitiveness of first generation MHD/steam plants with conventional steam plants over the range of 200 to 1000 MWe. The results show that net plant efficiency of the MHD plant is significantly higher than a conventional steam plant of corresponding size. The cost of electricity is also less for the MHD plant over the entire plant size range. As expected, the cost differential is higher for the larger plant and decreases with plant size. Even at the 200 MWe capacity, however, the differential in COE between the MHD plant and the conventional plant is sufficient attractive to warrant serious consideration. Escalating fuel costs will enhance the competitive position of MHD plants because they can utilize the fuel more efficiently than conventional steam plants.

  11. Potential problems with increasing serving sizes on the Nutrition Facts label.

    PubMed

    Dallas, Steven K; Liu, Peggy J; Ubel, Peter A

    2015-12-01

    The United States Food and Drug Administration recently announced that the serving sizes on the Nutrition Facts labels for many products will be increased, but the effect of these increases remains unclear. The present research examined consumers' interpretation of the meaning of serving size information (study 1) and tested whether exposing consumers to the increased serving sizes of the proposed Nutrition Facts label leads consumers to serve and purchase more food for themselves and others (studies 2-4). Study 1 (N = 101; 44.7% female) tested what consumers believe the serving sizes on Nutrition Facts labels refer to, and the majority of participants (over 78%) incorrectly believed that the serving sizes refer to how much food can or should be consumed in one sitting as part of a healthy diet. Study 2 (N = 51; 41.2% female) tested how exposure to the current versus proposed Nutrition Facts label influences the amount of food that consumers serve themselves, and studies 3 (N = 60; 46.7% female) and 4 (N = 61; 48.2% female) assessed how exposure to the current versus proposed label influences the amount of food that people serve and purchase for others. In studies 2-4, the proposed label (vs. the current label) led consumers to serve themselves 41% more cookies (study 2); serve 27% more cheese crackers to another person (study 3); and buy 43% more lasagnas for others and divide a lasagna into 22% larger slices (study 4). The results suggest that the proposed Nutrition Facts label's increased serving sizes may lead people who use this information as a reference to serve more food to themselves and others.

  12. HEC-cysteamine particles: influence of particle size, zeta potential, morphology and sulfhydryl groups on permeation enhancing properties.

    PubMed

    Rahmat, Deni; Müller, Christiane; Shahnaz, Gul; Leithner, Katharina; Laffleur, Flavia; Khan, Mohammad Imran; Martien, Ronny; Bernkop Schnürch, Andreas

    2013-09-01

    Within this study, the influence of particle size and zeta potential of hydroxyethyl cellulose-cysteamine particles on permeation enhancing properties was investigated. Particles were prepared by four different methods namely ionic gelation, spray drying, air jet milling and grinding. Particles prepared by grinding were additionally air jet milled. All particles were characterized in terms of particle size and zeta potential. The transport of fluorescein isothiocyanate-dextran 4 (FD4) across Caco-2 cell monolayers in the presence of these particles and the decrease in transepithelial electrical resistance (TEER) was evaluated. The cytotoxic effect of the particles was investigated using resazurin assay. Nanoparticles displaying a zeta potential of 3.3 ± 1.3 mV showed the highest enhancement of FD4 transport among all particles with a 5.83-fold improvement compared to buffer only. Due to the larger particle size, particles generated by grinding exhibited a lower capability in opening of tight junctions compared to smaller particles generated by air jet milling. In addition, the results of the transport studies were supported by the decrease in the TEER. All particle formulations tested were comparatively non-cytotoxic. Accordingly, the zeta potential and particle size showed a significant impact on the opening of tight junctions and hence could play an important role in the design of hydroxyethyl cellulose (HEC)-cysteamine-based nano- and micro-particles as drug delivery systems.

  13. Market analysis of seismic security systems

    NASA Technical Reports Server (NTRS)

    Taglio, S.

    1981-01-01

    This report provides information on the commercialization potential of the NASA Activity Monitor. Data on current commercially available products, market size, and growth are combined with information on the NASA technology and the projected impact of this technology on the market.

  14. Size-Tunable Synthesis of Stable Superparamagnetic Iron Oxide Nanoparticles for Potential Biomedical Applications

    PubMed Central

    Yu, Faquan; Yang, Victor C.

    2009-01-01

    Dextran-coated superparamagnetic nanoparticles (MNPs) have widespread biomedical applications. The superparamagnetic behavior, specifically regulated size, and smooth morphology are crucial requirements for essentially all of these applications. Presented herein is an innovative double-coating strategy that would allow for a size-controlled synthesis of MNPs. Small monocrystalline iron oxide nanoparticles (MIONs) were first synthesized, which served as the source of superparamagnetic properties. These MIONs were then treated in an acetate buffer containing biocompatible dextran polymer. Under such an environment, the colloidal MIONs would be quickly agglomerated by the acetate ions, and the formed coalescent body of MION would then be stabilized simultaneously by coating with dextran. By regulating the MION or dextran concentration as well as the thermal incubation time, the sizes of these first formed nanoparticles (termed 1st-NPs) could be readily controlled. A second dextran coating step was further applied to smoothen the 1st-NPs in attaining a final product (termed 2nd-NPs). The 2nd-NPs exhibited robustly storage stability due to the additional coating shell. Results successfully confirmed the plausibility of this approach, as these MNPs displayed not only a smooth outline and a narrow size distribution, but also the essential superparamagnetic behavior and a significantly prolonged stability upon storage. PMID:19402138

  15. Reproductive Potential of Salmon Spawning Substrates Inferred from Grain Size and Fish Length

    NASA Astrophysics Data System (ADS)

    Riebe, C. S.; Sklar, L. S.; Overstreet, B. T.; Wooster, J. K.; Bellugi, D. G.

    2014-12-01

    The river restoration industry spends millions of dollars every year on improving salmon spawning in riverbeds where sediment is too big for fish to move and thus use during redd building. However, few studies have addressed the question of how big is too big in salmon spawning substrates. Hence managers have had little quantitative basis for gauging the amount of spawning habitat in coarse-bedded rivers. Moreover, the scientific framework has remained weak for restoration projects that seek to improve spawning conditions. To overcome these limitations, we developed a physically based, field-calibrated model for the fraction of the bed that is fine-grained enough to support spawning by fish of a given size. Model inputs are fish length and easy-to-measure indices of bed-surface grain size. Model outputs include the number of redds and eggs the substrate can accommodate when flow depth, temperature, and other environmental factors are not limiting. The mechanistic framework of the model captures the biophysical limits on sediment movement and the space limitations on redd building and egg deposition in riverbeds. We explored the parameter space of the model and found a previously unrecognized tradeoff in salmon size: bigger fish can move larger sediment and thus use more riverbed area for spawning; they also tend to have higher fecundity, and so can deposit more eggs per redd; however, because redd area increases with fish length, the number of eggs a substrate can accommodate is highest for moderate-sized fish. One implication of this tradeoff is that differences in grain size may help regulate river-to-river differences in salmon size. Thus, our model suggests that population diversity and, by extension, species resilience are linked to lithologic, geomorphic, and climatic factors that determine grain size in rivers. We cast the model into easy-to-use look-up tables, charts, and computer applications, including a JavaScript app that works on tablets and mobile

  16. Application of shadow Doppler velocimetry to paint spray: potential and limitations in sizing optically inhomogeneous droplets

    NASA Astrophysics Data System (ADS)

    Morikita, Hiroshi; Taylor, Alexander M. K. P.

    1998-02-01

    This paper reports size measurement of droplets with optically inhomogeneous media by shadow Doppler velocimetry (SDV), which can provide spatially and temporally precise in situ readings of the size and velocity of a single particle with irregular shape and with arbitrary optical properties of the particle medium. In this work, water, instant coffee solution and water-based paint with various solid contents were measured to evaluate the capability and limitations of the measurement. The experiment with instant coffee solutions of 2 and 5% (wt:wt), which contained 0957-0233/9/2/009/img1m discrete particles, atomized by a standard paint spray gun, demonstrated that the accuracy of sizing was not affected by the optical properties of the medium. Insensitivity to the optical properties is one of the primary advantages of SDV over the other optical, single-particle sizing methods. As a further demonstration, paint samples atomized by the same gun containing solid flakes of nominal diameter 0957-0233/9/2/009/img2m were also measured. The results revealed a spatially uniform arithmetic mean diameter of 0957-0233/9/2/009/img3m and suggested that the atomization characteristics were influenced in the highest flake volume fraction case (red paint containing mica, 1.5%) with the result that the mean diameter was 20% larger than that of a similar paint with a smaller flake volume fraction (green paint containing aluminium, 0.4%). It was also found that the measurable number density is limited to no more than 1000 droplets 0957-0233/9/2/009/img4 in the case of droplets with an average size of 0957-0233/9/2/009/img5m.

  17. Study of integration issues to realize the market potential of OTEC energy in the aluminum industry. Final report

    SciTech Connect

    Jones, Jr., M. S.; Thiagarajan, V.; Sathyanarayana, K.; Markel, A. L.; Snyder, III, J. E.; Sprouse, A. M.; Leshaw, D.

    1980-09-01

    The various integration issues are studied which must be considered to realize the market potential for the use of OTEC by the aluminum industry. The chloride reduction process has been identified as an attractive candidate for use with OTEC systems, and drained-cathode Hall cells and two alternative chloride reduction processes are considered. OTEC power system and plantships for the different processes are described. Aluminum industry characteristics important for OTEC considerations are given, including economic models and case history analyses. Appended are supporting cost estimates and energy bridge concepts for getting OTEC energy to shore. (LEW)

  18. A Study of the Market Potential for Recruiting Non-Prior Service Females for Military Service. Volume 1. Supplement.

    DTIC Science & Technology

    1980-05-01

    AD -A143 3?? R STUDY OF THE MARET POTENTIAL FOR RECRUITING NON-PRIOR SERVICE FEMALES F..(U) GREY ADVERTISING INC 3 NEW YORK J T HEISLER NAY S0 *?831...having different sets of job interests, information about which the military can use in recruiting marketing and advertising . Key characterisitics of...20 + 4 R.O.T.C. - - HAVE SEEN/HEARD JOINT SERVICES AD 44 36 C Base: (181) (1419) < Significant at .05 Q.14a Have you seen or heard any advertising for

  19. A Perturbation Based Decomposition of Compound-Evoked Potentials for Characterization of Nerve Fiber Size Distributions.

    PubMed

    Szlavik, Robert B

    2016-02-01

    The characterization of peripheral nerve fiber distributions, in terms of diameter or velocity, is of clinical significance because information associated with these distributions can be utilized in the differential diagnosis of peripheral neuropathies. Electro-diagnostic techniques can be applied to the investigation of peripheral neuropathies and can yield valuable diagnostic information while being minimally invasive. Nerve conduction velocity studies are single parameter tests that yield no detailed information regarding the characteristics of the population of nerve fibers that contribute to the compound-evoked potential. Decomposition of the compound-evoked potential, such that the velocity or diameter distribution of the contributing nerve fibers may be determined, is necessary if information regarding the population of contributing nerve fibers is to be ascertained from the electro-diagnostic study. In this work, a perturbation-based decomposition of compound-evoked potentials is proposed that facilitates determination of the fiber diameter distribution associated with the compound-evoked potential. The decomposition is based on representing the single fiber-evoked potential, associated with each diameter class, as being perturbed by contributions, of varying degree, from all the other diameter class single fiber-evoked potentials. The resultant estimator of the contributing nerve fiber diameter distribution is valid for relatively large separations in diameter classes. It is also useful in situations where the separation between diameter classes is small and the concomitant single fiber-evoked potentials are not orthogonal.

  20. Genetic factors associated with population size may increase extinction risks and decrease colonization potential in a keystone tropical pine

    PubMed Central

    del Castillo, Rafael F; Trujillo-Argueta, Sonia; Sánchez-Vargas, Nahúm; Newton, Adrian C

    2011-01-01

    Pioneer species are essential for forest regeneration and ecosystem resilience. Pinus chiapensis is an endangered pioneer key species for tropical montane cloud forest regeneration in Mesoamerica. Human activities have severely reduced some P. chiapensis populations, which exhibited a small or null colonization potential suggesting the involvement of genetic factors associated with small populations. We explored the relationships between (i) population genetic diversity (allozymes) and population size, including sampling size effects, (ii) fitness estimates associated with colonization potential (seed viability and seedling performance) in a common environment and population size, and (iii) fitness estimates and observed heterozygosity in populations with sizes spanning five orders of magnitude. All the estimates of genetic diversity and fitness increased significantly with population size. Low fitness was detected in progenies of small populations of disturbed and undisturbed habitats. Progenies with the lowest observed heterozygosity displayed the lowest fitness estimates, which, in turn, increased with heterozygosity, but seed viability peaked at intermediate heterozygosity values suggesting inbreeding and outbreeding depression. Inbreeding depression appears to be the most immediate genetic factor in population decline. Conservation efforts should try to maintain large and genetically diverse populations, enhance gene flow by restoring connectivity between adjacent populations, and avoid genetically distant individuals. PMID:25568006

  1. Matters of Size: Genetic Bottlenecks in Virus Infection and Their Potential Impact on Evolution.

    PubMed

    Zwart, Mark P; Elena, Santiago F

    2015-11-01

    For virus infections of multicellular hosts, narrow genetic bottlenecks during transmission and within-host spread appear to be widespread. These bottlenecks will affect the maintenance of genetic variation in a virus population and the prevalence of mixed-strain infections, thereby ultimately determining the strength with which different random forces act during evolution. Here we consider different approaches for estimating bottleneck sizes and weigh their merits. We then review quantitative estimates of bottleneck size during cellular infection, within-host spread, horizontal transmission, and finally vertical transmission. In most cases we find that bottlenecks do regularly occur, although in many cases they appear to be virion-concentration dependent. Finally, we consider the evolutionary implications of genetic bottlenecks during virus infection. Although on average strong bottlenecks will lead to declines in fitness, we consider a number of scenarios in which bottlenecks could also be advantageous for viruses.

  2. Big data and large sample size: a cautionary note on the potential for bias.

    PubMed

    Kaplan, Robert M; Chambers, David A; Glasgow, Russell E

    2014-08-01

    A number of commentaries have suggested that large studies are more reliable than smaller studies and there is a growing interest in the analysis of "big data" that integrates information from many thousands of persons and/or different data sources. We consider a variety of biases that are likely in the era of big data, including sampling error, measurement error, multiple comparisons errors, aggregation error, and errors associated with the systematic exclusion of information. Using examples from epidemiology, health services research, studies on determinants of health, and clinical trials, we conclude that it is necessary to exercise greater caution to be sure that big sample size does not lead to big inferential errors. Despite the advantages of big studies, large sample size can magnify the bias associated with error resulting from sampling or study design.

  3. Crystal size of epidotes: A potentially exploitable geothermometer in geothermal fields

    SciTech Connect

    Patrier, P.; Beaufort, D.; Touchard, G. ); Fouillac, A.M. )

    1990-11-01

    Crystal size of epidotes crystallized in quartz + epidote veins is used as the basis for a new geothermometer from the fossil geothermal field of Saint Martin (Lesser Antilles). The epidote-bearing alteration paragenesis is developed as far as 3 km from a quartz diorite pluton at temperatures of 220-350C. The length/width ratio of the epidote grains is constant for all the analyzed samples and suggests isotropic growth environments. However, the length and width of the grains vary exponentially with temperature. The obtained results offer new perspectives for simple grain-size geothermomentry but must be extended to other geologic environments to clarify the influence of different rock types.

  4. Evolution of the U.S. Energy Service Company Industry: Market Size and Project Performance from 1990-2008

    SciTech Connect

    Larsen, Peter; Goldman, Charles A.; Satchwell, Andrew

    2012-05-08

    The U.S. energy service company (ESCO) industry is an example of a private sector business model where energy savings are delivered to customers primarily through the use of performance-based contracts. This study was conceived as a snapshot of the ESCO industry prior to the economic slowdown and the introduction of federal stimulus funding mandated by enactment of the American Recovery and Reinvestment Act of 2009 (ARRA). This study utilizes two parallel analytic approaches to characterize ESCO industry and market trends in the U.S.: (1) a “top-down” approach involving a survey of individual ESCOs to estimate aggregate industry activity and (2) a “bottom-up” analysis of a database of -3,265 projects (representing over $8B in project investment) that reports market trends including installed EE retrofit strategies, project installation costs and savings, project payback times, and benefit-cost ratios over time. Despite the onset of an economic recession, the U.S. ESCO industry managed to grow at about 7% per year between 2006 and 2008. ESCO industry revenues are relatively small compared to total U.S. energy expenditures (about $4.1 billion in 2008), but ESCOs anticipated accelerated growth through 2011 (25% per year). We found that 2,484 ESCO projects in our database generated -$4.0 billion ($2009) in net, direct economic benefits to their customers. We estimate that the ESCO project database includes about 20% of all U.S. ESCO market activity from 1990-2008. Assuming the net benefits per project are comparable for ESCO projects that are not included in the LBNL database, this would suggest that the ESCO industry has generated -$23 billion in net direct economic benefits for customers at projects installed between 1990 and 2008. We found that nearly 85% of all public and institutional projects met or exceeded the guaranteed level of savings. We estimated that a typical ESCO project generated $1.5 dollars of direct benefits for every dollar of customer

  5. Systemic granuloma observed in Atlantic salmon Salmo salar raised to market size in a freshwater recirculation aquaculture system

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Systemic granuloma was observed in sampled adult Atlantic salmon Salmo salar raised to harvest size in a freshwater recirculation aquaculture system. The prevalence of this condition was estimated at 10-20% of the population, with affected individuals grossly demonstrating pathology in varying degre...

  6. The potential impact of externalities considerations on the market for biomass power technologies

    NASA Astrophysics Data System (ADS)

    Swezey, B. G.; Porter, K. L.; Feher, J. S.

    1994-02-01

    This study assesses the current status of externalities considerations--nonmarket costs and benefits--in state and utility electricity resource planning processes and determines how externalities considerations might help or hinder the development of biomass power plants. It provides an overview of biomass resources and technologies, including their market status and environmental impacts; reviews the current treatment of externalities in the states; and documents the perspectives of key utility, regulatory, and industry representatives concerning externalities considerations. The authors make the following recommendations to the biomass industry: (1) the wood and agricultural waste industries should work toward having states and utilities recognize that wood and agricultural waste are greenhouse gas neutral resources because of carbon sequestration during growth; (2) the biomass industry should emphasize nonenvironmental benefits such as economic development and job creation; and (3) the biomass industry should pursue and support efforts to establish renewable energy set-asides or 'green' requests for proposals.

  7. The potential impact of externalities considerations on the market for biomass power technologies

    SciTech Connect

    Swezey, B.G.; Porter, K.L.; Feher, J.S.

    1994-02-01

    This study assesses the current status of externalities considerations--nonmarket costs and benefits--in state and utility electricity resource planning processes and determines how externalities considerations might help or hinder the development of biomass power plants. It provides an overview of biomass resources and technologies, including their market status and environmental impacts; reviews the current treatment of externalities in the states; and documents the perspectives of key utility, regulatory, and industry representatives concerning externalities considerations. The authors make the following recommendations to the biomass industry: (1) the wood and agricultural waste industries should work toward having states and utilities recognize that wood and agricultural waste are greenhouse gas neutral resources because of carbon sequestration during growth; (2) the biomass industry should emphasize nonenvironmental benefits such as economic development and job creation; and (3) the biomass industry should pursue and support efforts to establish renewable energy set-asides or ``green`` requests for proposals.

  8. Simulation of chemical potentials and phase equilibria in two- and three-dimensional square-well fluids: finite size effects.

    PubMed

    Vörtler, Horst L; Schäfer, Katja; Smith, William R

    2008-04-17

    We study the simulation cell size dependence of chemical potential isotherms in subcritical square-well fluids by means of series of canonical ensemble Monte Carlo simulations with increasing numbers of particles, for both three-dimensional bulk systems and two-dimensional planar layers, using Widom-like particle insertion methods. By estimating the corresponding vapor/liquid coexistence densities using a Maxwell-like equal area rule for the subcritical chemical potential isotherms, we are able to study the influence of system size not only on chemical potentials but also on the coexistence properties. The chemical potential versus density isotherms show van der Waals-like loops in the subcritical vapor/liquid coexistence range that exhibit distinct finite size effects for both two- and three-dimensional fluids. Generally, in agreement with recent findings for related studies of Lennard-Jones fluids, the loops shrink with increasing number of particles. In contrast to the subcritical isotherms themselves, the equilibrium vapor/liquid densities show only a weak system size dependence and agree quantitatively with the best-known literature values for three-dimensional fluids. This allows our approach to be used to accurately predict the phase coexistence properties. Our resulting phase equilibrium results for two-dimensional square-well fluids are new. Knowledge concerning finite size effects of square-well systems is important not only for the simulation of thermodynamic properties of simple fluids, but also for the simulation of models of more complex fluids (such as aqueous or polymer fluids) involving square-well interactions.

  9. Crystallographic studies of V44 mutants of Clostridium pasteurianum rubredoxin: Effects of side-chain size on reduction potential

    SciTech Connect

    Park, Il Yeong; Eidsness, Marly K.; Lin, I-Jin; Gebel, Erika B.; Youn, Buhyun; Harley, Jill L.; Machonkin, Timothy E.; Frederick, Ronnie O.; Markley, John L.; Smith, Eugene T.; Ichiye, Toshiko; Kang, ChulHee

    2010-11-16

    Understanding the structural origins of differences in reduction potentials is crucial to understanding how various electron transfer proteins modulate their reduction potentials and how they evolve for diverse functional roles. Here, the high-resolution structures of several Clostridium pasteurianum rubredoxin (Cp Rd) variants with changes in the vicinity of the redox site are reported in order to increase this understanding. Our crystal structures of [V44L] (at 1.8 {angstrom} resolution), [V44A] (1.6 {angstrom}), [V44G] (2.0 {angstrom}) and [V44A, G45P] (1.5 {angstrom}) Rd (all in their oxidized states) show that there is a gradual decrease in the distance between Fe and the amide nitrogen of residue 44 upon reduction in the size of the side chain of residue 44; the decrease occurs from leucine to valine, alanine or glycine and is accompanied by a gradual increase in their reduction potentials. Mutation of Cp Rd at position 44 also changes the hydrogen-bond distance between the amide nitrogen of residue 44 and the sulfur of cysteine 42 in a size-dependent manner. Our results suggest that residue 44 is an important determinant of Rd reduction potential in a manner dictated by side-chain size. Along with the electric dipole moment of the 43-44 peptide bond and the 44-42 NHS type hydrogen bond, a modulation mechanism for solvent accessibility through residue 41 might regulate the redox reaction of the Rds. Proteins 2004.

  10. Finite size effects in the presence of a chemical potential: A study in the classical nonlinear O(2) sigma model

    NASA Astrophysics Data System (ADS)

    Banerjee, Debasish; Chandrasekharan, Shailesh

    2010-06-01

    In the presence of a chemical potential, the physics of level crossings leads to singularities at zero temperature, even when the spatial volume is finite. These singularities are smoothed out at a finite temperature but leave behind nontrivial finite size effects which must be understood in order to extract thermodynamic quantities using Monte Carlo methods, particularly close to critical points. We illustrate some of these issues using the classical nonlinear O(2) sigma model with a coupling β and chemical potential μ on a 2+1-dimensional Euclidean lattice. In the conventional formulation this model suffers from a sign problem at nonzero chemical potential and hence cannot be studied with the Wolff cluster algorithm. However, when formulated in terms of the worldline of particles, the sign problem is absent, and the model can be studied efficiently with the “worm algorithm.” Using this method we study the finite size effects that arise due to the chemical potential and develop an effective quantum mechanical approach to capture the effects. As a side result we obtain energy levels of up to four particles as a function of the box size and uncover a part of the phase diagram in the (β,μ) plane.

  11. Foods from black market at EU border as a neglected route of potential methicillin-resistant Staphylococcus aureus transmission.

    PubMed

    Oniciuc, Elena-Alexandra; Ariza-Miguel, Jaime; Bolocan, Andrei-Sorin; Diez-Valcarce, Marta; Rovira, Jordi; Hernández, Marta; Fernández-Natal, Isabel; Nicolau, Anca Ioana; Rodríguez-Lázaro, David

    2015-09-16

    The illegal entrance of foods to EU through black markets at the EU borders can constitute a neglected route of dissemination of foodborne pathogens, and in particular of methicillin-resistant Staphylococcus aureus (MRSA). In this study, we have assessed the presence of MRSA in foods sold in a black market at an EU border (the southeast part of Romania, on the border with Republic of Moldavia). We performed a search for MRSA among 200 food samples collected from 2012 to 2013. All S. aureus were studied by pulsed-field gel electrophoresis (PFGE) and antimicrobial susceptibility testing. MRSA isolates were further characterized by multilocus sequence typing (MLST) and SCCmec typing, and tested for the presence of Panton-Valentine leukocidin (PVL) virulence factors. Overall, 32 S. aureus isolates were recovered from 16 food samples (8%). One isolate detected in a pork lard sample was MRSA (0.5%). PFGE with the restriction enzyme SmaI revealed 12 genotypes among the 32 S. aureus isolates. The MRSA isolate belonged to sequence type 398, harbored SCCmec type V, tested negative for the presence of the PVL genes and was resistant to ciprofloxacin, tetracycline and cefazolin, besides all β-lactams. Among 31 methicillin-sensitive S. aureus (MSSA), 29% were resistant to penicillin, 9.7% to tetracycline and 3.2% to ciprofloxacin. In conclusion, in this study we report the presence of livestock-associated MRSA in foods sold in a black market at an EU border: ST398-MRSA-V. These results confirm the potential role of food in the dissemination of MRSA lineages among population, and the potential role of illegally introduced food to EU in the prevalence and evolution of MRSA clones in the community.

  12. Geothermal direct heat use: market potential/penetration analysis for Federal Region IX (Arizona, California, Hawaii, Nevada)

    SciTech Connect

    Powell, W.; Tang, K.

    1980-05-01

    A preliminary study was made of the potential for geothermal direct heat use in Arizona, California, Hawaii, and Nevada (Federal Region IX). The analysis for each state was performed by a different team, located in that state. For each state, the study team was asked to: (1) define the resource, based on the latest available data; (2) assess the potential market growth for geothermal energy; and (3) estimate the market penetration, projected to 2020. Each of the four states of interest in this study is unique in its own way. Rather than impose the same assumptions as to growth rates, capture rates, etc. on all of the study teams, each team was asked to use the most appropriate set of assumptions for its state. The results, therefore, should reflect the currently accepted views within each state. The four state reports comprise the main portion of this document. A brief regional overview section was prepared by the Jet Propulsion Laboratory, following completion of the state reports.

  13. Potential impact of mangrove clearance on biomass and biomass size spectra of nematode along the Sudanese Red Sea coast.

    PubMed

    Sabeel, Rasha Adam Osman; Vanreusel, Ann

    2015-02-01

    The potential effect of mangrove clearance on nematode assemblage biomass, biomass size spectra (NBSS) and abundance/biomass curves (ABC) was investigated in three sites representing a varying degree of mangrove clearance as well as in three stations established at each sites representing high-, mid- and low-water levels. Results revealed significant differences in sediment and nematode characteristics between the three sites. Although both the cleared and the intact mangrove had comparable biomass values, clear differences in biomass size spectra and abundance biomass curves were observed. The results suggested that the variation in the silt fraction and the food quality positively affected the total biomass. Mangrove clearance has caused a shift from a unimodal to a bimodal biomass size spectrum at all water levels, owing to an increase in smaller-bodied opportunistic non-selective deposit feeding nematodes. The ABC further confirmed the effect of clearance by classifying the cleared mangrove as moderately to grossly disturbed.

  14. Potentially spurious correlations between arterial size, flow-mediated dilation, and shear rate.

    PubMed

    Veglia, Fabrizio; Amato, Mauro; Giovannardi, Marta; Ravani, Alessio; Tedesco, Calogero C; Frigerio, Beatrice; Sansaro, Daniela; Tremoli, Elena; Baldassarre, Damiano

    2014-12-01

    The use of indices formed from the ratio of 2 variables often generates spurious correlations with other variables that are mathematically coupled. In this context, we examined the correlations between percent flow-mediated dilation, baseline diameter, and shear rate. In a sample of 315 participants, with and without substantial vascular risk factors, the observed correlation coefficients between the variables were of a similar magnitude to those reported in the literature. We then applied a Monte Carlo procedure based on random permutations to remove any physical or physiological explanation for these correlations. We found that the median residual correlation coefficients were comparable with those observed in our original sample. When the confounding influence of artery size was adjusted for, the mean difference in percent flow-mediated dilation between high-risk and low-risk samples was halved. These findings indicate that the widely reported correlations between flow-mediated dilation, basal artery diameter, and shear rate have a substantial spurious component. This is because percent flow-mediated dilation and shear rate are mathematically coupled to artery size.

  15. A Delphi exercise used to identify potential causes of variation in litter size of Ontario swine

    PubMed Central

    Dewey, Catherine E.; Martin, S. Wayne; Friendship, Robert M.; Kennedy, Brain

    1992-01-01

    Forty-eight people, considered to the swine experts, were asked to collaborate in a Delphi exercise to identify the factors which they believed affect litter size in Ontario swine. The panel included 16 animal scientists, 16 pork producers, and 16 veterinarians in swine practice. The ten factors with the highest ratings were parity of the sow, mycotoxins in the feed, infections with porcine parvovirus or Leptospira spp., breeding gilts on their second versus first observed estrus, the timing of breeding with respect to the onset of estrus, purebred versus crossbred sows, boar overuse (bred by a boar that was mated more than six times per week), pen versus hand mating, age of gilt when first bred, and body condition of the sow at the time of conception. The experts did not agree about the effect on litter size of the sow's previous lactation, factors ensuring adequate nutrient intake during lactation, health of the sow and the boar, breed of a purebred sow, or the ease of mating the sow. Key items in the use of the Delphi technique to arrive at a consensus are discussed. PMID:17423928

  16. Species and Size Composition of Seahorses (Genus Hippocampus, Family Syngnathidae) in the Coastal Waters and Local Market of Kota Kinabalu, Sabah, Malaysia

    PubMed Central

    Shapawi, Rossita; Anyie, Adrian Leslie; Hussien, Muhammad Ali Syed; Zuldin, Wahidatul Husna

    2015-01-01

    Seahorse diversity (genus Hippocampus, Family Syngnathidae), species identification, size composition and sexual dimorphism were studied from November 2012 to March 2013 in selected coastal waters around Kota Kinabalu, Sabah and the local market trade. Six species of seahorses were identified in the study: (1) Hippocampus barbouri, (2) Hippocampus comes, (3) Hippocampus kelloggi, (4) Hippocampus kuda, (5) Hippocampus spinosissimus and (6) Hippocampus trimaculatus. All six species were sold at the local market, and the dried seahorses were obtained mainly by local fishermen using trawl by-catch method and traded as traditional medicine, souvenirs and other uses. Four species were identified by direct samplings in various different habitats of Kota Kinabalu coastal waters: (1) H. barbouri, (2) H. comes, (3) H. kuda, and (4) H. spinosissimus. Based on the results, H. comes was the largest in size among the four fresh/live species found (mean standard length [SL]: 148.25±1.26 mm), whereas H. barbouri was the smallest species (mean SL: 129±7.81 mm). For the dried samples, H. kelloggi was the largest (mean SL: 245.25±14.55 mm) and H. barbouri was the smallest (mean SL: 127.21±10.01 mm). No significant difference (p>0.05) was observed between the lengths of males and females in every seahorse species, and there was no sexual size dimorphism in any of the species. The findings from the study are significant to provide baseline data for the conservation efforts of these unique marine teleost. PMID:26868706

  17. Interlaboratory comparison for the measurement of particle size and zeta potential of silica nanoparticles in an aqueous suspension

    NASA Astrophysics Data System (ADS)

    Lamberty, Andrée; Franks, Katrin; Braun, Adelina; Kestens, Vikram; Roebben, Gert; Linsinger, Thomas P. J.

    2011-12-01

    The Institute for Reference Materials and Measurements has organised an interlaboratory comparison (ILC) to allow the participating laboratories to demonstrate their proficiency in particle size and zeta potential measurements on monomodal aqueous suspensions of silica nanoparticles in the 10-100 nm size range. The main goal of this ILC was to identify competent collaborators for the production of certified nanoparticle reference materials. 38 laboratories from four different continents participated in the ILC with different methods for particle sizing and determination of zeta potential. Most of the laboratories submitted particle size results obtained with centrifugal liquid sedimentation (CLS), dynamic light scattering (DLS) or electron microscopy (EM), or zeta potential values obtained via electrophoretic light scattering (ELS). The results of the laboratories were evaluated using method-specific z scores, calculated on the basis of consensus values from the ILC. For CLS (13 results) and EM (13 results), all reported values were within the ±2 | z| interval. For DLS, 25 of the 27 results reported were within the ±2 | z| interval, the two other results were within the ±3 | z| interval. The standard deviations of the corresponding laboratory mean values varied between 3.7 and 6.5%, which demonstrates satisfactory interlaboratory comparability of CLS, DLS and EM particle size values. From the received test reports, a large discrepancy was observed in terms of the laboratory's quality assurance systems, which are equally important for the selection of collaborators in reference material certification projects. Only a minority of the participating laboratories is aware of all the items that are mandatory in test reports compliant to ISO/IEC 17025 (ISO General requirements for the competence of testing and calibration laboratories. International Organisation for Standardization, Geneva, 2005b). The absence of measurement uncertainty values in the reports, for

  18. Size-frequency analysis of petroleum accumulations in selected United States plays: potential analogues for frontier areas

    USGS Publications Warehouse

    Attanasi, E.D.; Freeman, P.A.

    2004-01-01

    This report presents the petroleum accumulation size-frequency relationships of selected mature plays assessed in the U.S. Geological Survey?s 1995 National Assessment of Oil and Gas Resources. The plays provide assessors with potential analogue models from which to estimate the numbers of undiscovered accumulations in medium and smaller size categories. Each play selected was required to have at least 50 discovered accumulations. Discovered accumulations plus the mean number of undiscovered accumulations equals the total accumulations assessed at the play level. There were 36 plays that met the criteria for oil accumulations and 25 plays that met the criteria for gas accumulations. Other properties of the plays such as primary trap type, lithology, depth, and hydrocarbon characteristics are also provided to assist the geologist in choosing an appropriate analogue. The text explains how the analogue size-frequency relationships can be used to estimate the number of small and medium size accumulations for frontier-area plays or partially explored plays in high cost areas. Although this document has been written in support of the Alaska North Slope Assessment, the basic size?frequency relationships provided are applicable elsewhere.

  19. Study sizes up Iraq`s reserves, exploration status, production potential

    SciTech Connect

    Ibrahim, M.W.

    1996-06-24

    Iraq has a volatile exploration and production history, but unlike more stable OAPEC countries it was National Oil Co. (INOC) rather than foreign oil companies that discovered most of the country`s proved oil reserves. Proved reserves are in Paleozoic, Triassic, Jurassic, Cretaceous, and Tertiary reservoirs charged by Silurian and Jurassic and/or Cretaceous source rocks. The pre-gulf war production capacity was 3.5 million b/d, but the country`s current damaged production capacity is about 2.5 million b/d. New discoveries have elevated Iraq`s proved reserves to 120 billion bbl of oil. The paper discusses exploration history, proven reserves, exploration plays, exploration potential, and production potential.

  20. Utilization of solar energy in developing countries: Identifying some potential markets

    NASA Technical Reports Server (NTRS)

    Hein, G. F.; Siddiqi, T. A.

    1978-01-01

    The potential use of solar electricity generated from photovoltaic cells is examined for nineteen developing nations. Energy and economic profiles are summarized for each country. A comparison is made between the use of autogeneration and photovoltaics in a rural area of Haiti.

  1. 76 FR 58463 - National Defense Stockpile Market Impact Committee Request for Public Comments on the Potential...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ... Powder LB W 77,433 2 3 Tungsten Ores and Concentrates LB W 5,069,782 2 3 \\1\\ Potential Disposal/Upgrade... disposal levels of materials for the Fiscal Year (FY) 2013 Annual Materials Plan. The role of the MIC is to... all acquisitions and disposals of materials from the stockpile. Public comments are an...

  2. Using Geothermal Play Types as an Analogue for Estimating Potential Resource Size

    SciTech Connect

    Terry, Rachel; Young, Katherine

    2015-09-02

    Blind geothermal systems are becoming increasingly common as more geothermal fields are developed. Geothermal development is known to have high risk in the early stages of a project development because reservoir characteristics are relatively unknown until wells are drilled. Play types (or occurrence models) categorize potential geothermal fields into groups based on geologic characteristics. To aid in lowering exploration risk, these groups' reservoir characteristics can be used as analogues in new site exploration. The play type schemes used in this paper were Moeck and Beardsmore play types (Moeck et al. 2014) and Brophy occurrence models (Brophy et al. 2011). Operating geothermal fields throughout the world were classified based on their associated play type, and then reservoir characteristics data were catalogued. The distributions of these characteristics were plotted in histograms to develop probability density functions for each individual characteristic. The probability density functions can be used as input analogues in Monte Carlo estimations of resource potential for similar play types in early exploration phases. A spreadsheet model was created to estimate resource potential in undeveloped fields. The user can choose to input their own values for each reservoir characteristic or choose to use the probability distribution functions provided from the selected play type. This paper also addresses the United States Geological Survey's 1978 and 2008 assessment of geothermal resources by comparing their estimated values to reported values from post-site development. Information from the collected data was used in the comparison for thirty developed sites in the United States. No significant trends or suggestions for methodologies could be made by the comparison.

  3. Improving biodegradation potential of domestic wastewater by manipulating the size distribution of organic matter.

    PubMed

    Liu, Xiang; Chen, Qiuwen; Zhu, Liang

    2016-09-01

    Carbon source is a critical constraint on nutrient removal in domestic wastewater treatment. However, the functions of particulate organic matter (POM) and some organics with high molecular weight (HMW) are overlooked in the conventional process, as they cannot be directly assimilated into cells during microbial metabolism. This further aggravates the problem of carbon source shortage and thus affects the effluent quality. Therefore, to better characterize organic matter (OM) based MW distribution, microfiltration/ultrafiltration/nanofiltration (MF/UF/NF) membranes were used in parallel to fractionate OM, which obtained seven fractions. Hydrolysis acidification (HA) was adopted to manipulate the MW distribution of dissolved organic matter (DOM) and further explore the correlation between molecular size and biodegradability. Results showed that HA pretreatment of wastewater not only promoted transformation from POM to DOM, but also boosted biodegradability. After 8hr of HA, the concentration of dissolved organic carbon (DOC) increased by 65%, from the initial value of 20.25 to 33.48mg/L, and the biodegradability index (BOD5 (biochemical oxygen demand)/SCOD (soluble chemical oxygen demand)) increased from 0.52 to 0.74. Using MW distribution analysis and composition optimization, a new understanding on the characteristics of organics in wastewater was obtained, which is of importance to solving low C/N wastewater treatment in engineering practice.

  4. From streets to streams: assessing the toxicity potential of urban sediment by particle size

    USGS Publications Warehouse

    Corsi, Steven R.; Selbig, William R.; Roger T. Bannerman,; ,

    2013-01-01

    Urban sediment can act as a transport mechanism for a variety of pollutants to move towards a receiving water body. The concentrations of these pollutants oftentimes exceed levels that are toxic to aquatic organisms. Many treatment structures are designed to capture coarse sediment but do not work well to similarly capture the fines. This study measured concentrations of select trace metals and PAHs in both the silt and sand fractions of urban sediment from four sources: stormwater bed, stormwater suspended, street dirt, and streambed. Concentrations were used to assess the toxic potential of sediment based on published sediment quality guidelines. All sources of sediment showed some level of toxic potential with stormwater bed sediment the highest followed by stormwater suspended, street dirt, and streambed. Both metal and PAH concentration distributions were highly correlated between the four sampling locations suggesting the presence of one or perhaps only a few sources of these pollutants which remain persistent as sediment is transported from street to stream. Comparison to other forms of combustion- and vehicle-related sources of PAHs revealed coal tar sealants to have the strongest correlation, in both the silt and sand fractions, at all four sampling sites. This information is important for environmental managers when selecting the most appropriate Best Management Practice (BMP) as a way to mitigate pollution conveyed in urban stormwater from source to sink.

  5. Impact of matric potential and pore size distribution on growth dynamics of filamentous and non-filamentous soil bacteria.

    PubMed

    Wolf, Alexandra B; Vos, Michiel; de Boer, Wietse; Kowalchuk, George A

    2013-01-01

    The filamentous growth form is an important strategy for soil microbes to bridge air-filled pores in unsaturated soils. In particular, fungi perform better than bacteria in soils during drought, a property that has been ascribed to the hyphal growth form of fungi. However, it is unknown if, and to what extent, filamentous bacteria may also display similar advantages over non-filamentous bacteria in soils with low hydraulic connectivity. In addition to allowing for microbial interactions and competition across connected micro-sites, water films also facilitate the motility of non-filamentous bacteria. To examine these issues, we constructed and characterized a series of quartz sand microcosms differing in matric potential and pore size distribution and, consequently, in connection of micro-habitats via water films. Our sand microcosms were used to examine the individual and competitive responses of a filamentous bacterium (Streptomyces atratus) and a motile rod-shaped bacterium (Bacillus weihenstephanensis) to differences in pore sizes and matric potential. The Bacillus strain had an initial advantage in all sand microcosms, which could be attributed to its faster growth rate. At later stages of the incubation, Streptomyces became dominant in microcosms with low connectivity (coarse pores and dry conditions). These data, combined with information on bacterial motility (expansion potential) across a range of pore-size and moisture conditions, suggest that, like their much larger fungal counterparts, filamentous bacteria also use this growth form to facilitate growth and expansion under conditions of low hydraulic conductivity. The sand microcosm system developed and used in this study allowed for precise manipulation of hydraulic properties and pore size distribution, thereby providing a useful approach for future examinations of how these properties influence the composition, diversity and function of soil-borne microbial communities.

  6. The Long-Term Market Potential of Concentrating Solar Power (CSP) Systems

    SciTech Connect

    Smith, Steven J.

    2012-10-30

    This chapter will examine the conditions under which thermal CSP systems might play a large role in the global energy system. CSP technologies, such as troughs or power towers, have a large advantage over other solar technologies in that they offer the potential for firm power delivery, mitigating intermittency issues. These systems require relatively cloud-free conditions to operate, which limits their geographic applicability.

  7. Novel Method for Sizing Metallic Bottom Crack Depth Using Multi-frequency Alternating Current Potential Drop Technique

    NASA Astrophysics Data System (ADS)

    Li, Yuting; Gan, Fangji; Wan, Zhengjun; Liao, Junbi; Li, Wenqiang

    2015-10-01

    Potential drop techniques are of two types: the direct current potential drop (DCPD) technique and alternating current potential drop (ACPD) technique, and both of them are used in nondestructive testing. ACPD, as a kind of valid method in sizing metal cracks, has been applied to evaluate metal structures. However, our review of most available approaches revealed that some improvements can be done in measuring depth of metal bottom crack by means of ACPD, such as accuracy and sensitivity of shallow crack. This paper studied a novel method which utilized the slope of voltage ratio-frequency curve to solve bottom crack depth by using a simple mathematic equation based on finite element analysis. It is found that voltage ratio varies linearly with frequency in the range of 5-15 Hz; this range is slightly higher than the equivalent frequency and lower than semi-permeable frequency. Simulation and experiment show that the novel method can measure the bottom crack depth accurately.

  8. Potential Market for Satellite Technology in Meeting Telecommunication Needs of Developing Nations

    NASA Technical Reports Server (NTRS)

    1996-01-01

    A recent study examined the potential for satellite technology to meet the telecommunication needs of developing nations. The growth of these nations depends on their attracting and holding the industrial investments of developed nations. This will not be likely with the antiquated telecommunications infrastructure typical of developing nations. On the contrary, it will require an infrastructure that is compatible with international standards. Most of the developing nations perceive this necessity and are pursuing the necessary upgrades. The rate of replacement, types of technology, services affected, and the terrestrial/satellite mix differ by each nation's priorities and gross national product (GNP).

  9. Chemical potential of a test hard sphere of variable size in a hard-sphere fluid

    NASA Astrophysics Data System (ADS)

    Heyes, David M.; Santos, Andrés

    2016-12-01

    The Labík and Smith Monte Carlo simulation technique to implement the Widom particle insertion method is applied using Molecular Dynamics (MD) instead to calculate numerically the insertion probability, P0(η ,σ0) , of tracer hard-sphere (HS) particles of different diameters, σ0, in a host HS fluid of diameter σ and packing fraction, η , up to 0.5. It is shown analytically that the only polynomial representation of -ln ⁡P0 (η ,σ0) consistent with the limits σ0→0 and σ0→∞ has necessarily a cubic form, c0(η ) +c1(η ) σ0 /σ +c2(η ) (σ0/σ ) 2 +c3(η ) (σ0/σ ) 3 . Our MD data for -ln ⁡P0 (η ,σ0) are fitted to such a cubic polynomial and the functions c0(η ) and c1(η ) are found to be statistically indistinguishable from their exact solution forms. Similarly, c2(η ) and c3(η ) agree very well with the Boublík-Mansoori-Carnahan-Starling-Leland and Boublík-Carnahan-Starling-Kolafa formulas. The cubic polynomial is extrapolated (high density) or interpolated (low density) to obtain the chemical potential of the host fluid, or σ0→σ , as β μex =c0+c1+c2+c3 . Excellent agreement between the Carnahan-Starling and Carnahan-Starling-Kolafa theories with our MD data is evident.

  10. Potential (Mis)match? Marriage Markets Amidst Sociodemographic Change in India, 2005-2050.

    PubMed

    Kashyap, Ridhi; Esteve, Albert; García-Román, Joan

    2015-02-01

    We explore the impact of sociodemographic change on marriage patterns in India by examining the hypothetical consequences of applying three sets of marriage pairing propensities-contemporary patterns by age, contemporary patterns by age and education, and changing propensities that allow for greater educational homogamy and reduced educational asymmetries--to future population projections. Future population prospects for India indicate three trends that will impact marriage patterns: (1) female deficit in sex ratios at birth; (2) declining birth cohort size; (3) female educational expansion. Existing literature posits declining marriage rates for men arising from skewed sex ratios at birth (SRBs) in India's population. In addition to skewed SRBs, India's population will experience female educational expansion in the coming decades. Female educational expansion and its impact on marriage patterns must be jointly considered with demographic changes, given educational differences and asymmetries in union formation that exist in India, as across much of the world. We systematize contemporary pairing propensities using data from the 2005-2006 Indian National Family Health Survey and the 2004 Socio-Economic Survey and apply these and the third set of changing propensities to multistate population projections by educational attainment using an iterative longitudinal projection procedure. If today's age patterns of marriage are viewed against age/sex population composition until 2050, men experience declining marriage prevalence. However, when education is included, women--particularly those with higher education--experience a more salient rise in nonmarriage. Significant changes in pairing patterns toward greater levels of educational homogamy and gender symmetry can counteract a marked rise in nonmarriage.

  11. Potential (mis)match?: Marriage Markets amidst Socio-Demographic Change in India, 2005–2050

    PubMed Central

    Kashyap, Ridhi; Esteve, Albert; García-Román, Joan

    2015-01-01

    We explore the impact of socio-demographic change on marriage patterns in India by examining the hypothetical consequences of applying three sets of marriage pairing propensities – contemporary patterns by age, by age and education, and changing propensities that allow for greater educational homogamy and reduced educational asymmetries – to future population projections. Future population prospects for India indicate three trends that will impact marriage patterns: i) female-deficit in sex ratios at birth; ii) declining birth cohort size; iii) female educational expansion. Existing literature posits declining marriage rates for men arising from skewed sex ratios at birth (SRB) in India’s population. In addition to skewed SRBs, India’s population will experience female educational expansion in the coming decades. Female educational expansion and its impact on marriage patterns must be jointly considered with demographic changes, given educational differentials and asymmetries in union formation that exist in India, as across much of the world. We systematize contemporary pairing propensities using data from the 2005–2006 Indian National Family Health Survey and the 2004 Socio-Economic Survey and apply these and the third set of changing propensities to IIASA/VID multi-state population projections by educational attainment using an iterative longitudinal projection procedure. If today’s age patterns of marriage are viewed against age-sex population composition until 2050, men experience declining marriage prevalence. However, when education is included, women, particularly those with higher education experience a more salient rise in non-marriage. Significant changes in pairing patterns towards greater levels of educational homogamy and gender symmetry can counteract a marked rise in non-marriage. PMID:25604846

  12. Spray droplet size, drift potential, and risks to nontarget organisms from aerially applied glyphosate for coca control in Colombia.

    PubMed

    Hewitt, Andrew J; Solomon, Keith R; Marshall, E J P

    2009-01-01

    A wind tunnel atomization study was conducted to measure the emission droplet size spectra for water and Glyphos (a glyphosate formulation sold in Colombia) + Cosmo-flux sprays for aerial application to control coca and poppy crops in Colombia. The droplet size spectra were measured in a wind tunnel for an Accu-Flo nozzle (with 16 size 0.085 [2.16 mm] orifices), under appropriate simulated aircraft speeds (up to 333 km/h), using a laser diffraction instrument covering a dynamic size range for droplets of 0.5 to 3,500 microm. The spray drift potential of the glyphosate was modeled using the AGDISP spray application and drift model, using input parameters representative of those occurring in Colombia for typical aerial application operations. The droplet size spectra for tank mixes containing glyphosate and Cosmo-Flux were considerably finer than water and became finer with higher aircraft speeds. The tank mix with 44% glyphosate had a D(v0.5) of 128 microm, while the value at the 4.9% glyphosate rate was 140 microm. These are classified as very fine to fine sprays. Despite being relatively fine, modeling showed that the droplets would not evaporate as rapidly as most similarly sized agricultural sprays because the nonvolatile proportion of the tank mix (active and inert adjuvant ingredients) was large. Thus, longer range drift is small and most drift that does occur will deposit relatively close to the application area. Drift will only occur downwind and, with winds of velocity less than the modeled maximum of 9 km/h, the drift distance would be substantially reduced. Spray drift potential might be additionally reduced through various practices such as the selection of nozzles, tank mix adjuvants, aircraft speeds, and spray pressures that would produce coarser sprays. Species sensitivity distributions to glyphosate were constructed for plants and amphibians. Based on modeled drift and 5th centile concentrations, appropriate no-spray buffer zones (distance from the

  13. Solar thermal technology development: Estimated market size and energy cost savings. Volume 2: Assumptions, methodology and results

    NASA Technical Reports Server (NTRS)

    Gates, W. R.

    1983-01-01

    Estimated future energy cost savings associated with the development of cost-competitive solar thermal technologies (STT) are discussed. Analysis is restricted to STT in electric applications for 16 high-insolation/high-energy-price states. Three fuel price scenarios and three 1990 STT system costs are considered, reflecting uncertainty over future fuel prices and STT cost projections. Solar thermal technology research and development (R&D) is found to be unacceptably risky for private industry in the absence of federal support. Energy cost savings were projected to range from $0 to $10 billion (1990 values in 1981 dollars), depending on the system cost and fuel price scenario. Normal R&D investment risks are accentuated because the Organization of Petroleum Exporting Countries (OPEC) cartel can artificially manipulate oil prices and undercut growth of alternative energy sources. Federal participation in STT R&D to help capture the potential benefits of developing cost-competitive STT was found to be in the national interest. Analysis is also provided regarding two federal incentives currently in use: The Federal Business Energy Tax Credit and direct R&D funding.

  14. Solar thermal technology development: Estimated market size and energy cost savings. Volume 2: Assumptions, methodology and results

    NASA Astrophysics Data System (ADS)

    Gates, W. R.

    1983-02-01

    Estimated future energy cost savings associated with the development of cost-competitive solar thermal technologies (STT) are discussed. Analysis is restricted to STT in electric applications for 16 high-insolation/high-energy-price states. Three fuel price scenarios and three 1990 STT system costs are considered, reflecting uncertainty over future fuel prices and STT cost projections. Solar thermal technology research and development (R&D) is found to be unacceptably risky for private industry in the absence of federal support. Energy cost savings were projected to range from $0 to $10 billion (1990 values in 1981 dollars), depending on the system cost and fuel price scenario. Normal R&D investment risks are accentuated because the Organization of Petroleum Exporting Countries (OPEC) cartel can artificially manipulate oil prices and undercut growth of alternative energy sources. Federal participation in STT R&D to help capture the potential benefits of developing cost-competitive STT was found to be in the national interest. Analysis is also provided regarding two federal incentives currently in use: The Federal Business Energy Tax Credit and direct R&D funding.

  15. Potential Risks in the Paradigm of Basic to Translational Research: A Critical Evaluation of qPCR Telomere Size Techniques

    PubMed Central

    Lustig, Arthur J

    2015-01-01

    Real time qPCR has become the method of choice for rapid large-scale telomere length measurements. Large samples sizes are critical for clinical trials, and epidemiological studies. QPCR has become such routine procedure that it is often used with little critical analysis. With proper controls, the mean telomere size can be derived from the data and even the size can be estimated. But there is a need for more consistent and reliable controls that will provide closer to the actual mean size can be obtained with uniform consensus controls. Although originating at the level of basic telomere research, many researchers less familiar with telomeres often misunderstand the source and significance of the qPCR metric. These include researchers and clinicians who are interested in having a rapid tool to produce exciting results in disease prognostics and diagnostics than in the multiple characteristics of telomeres that form the basis of the measurement. But other characteristics of the non-bimodal and heterogeneous telomeres as well as the complexities of telomere dynamics are not easily related to qPCR mean telomere values. The qPCR metric does not reveal the heterogeneity and dynamics of telomeres. This is a critical issue since mutations in multiple genes including telomerase can cause telomere dysfunction and a loss of repeats. The smallest cellular telomere has been shown to arrest growth of the cell carrying the dysfunction telomere. A goal for the future is a simple method that takes into account the heterogeneity by measuring the highest and lowest values as part of the scheme to compare. In the absence of this technique, Southern blots need to be performed in a subset of qPCR samples for both mean telomere size and the upper and lower extremes of the distribution. Most importantly, there is a need for greater transparency in discussing the limitations of the qPCR data. Given the potentially exciting qPCR telomere size results emerging from clinical studies that

  16. Variability in bioreactivity linked to changes in size and zeta potential of diesel exhaust particles in human immune cells.

    PubMed

    Sarkar, Srijata; Zhang, Lin; Subramaniam, Prasad; Lee, Ki-Bum; Garfunkel, Eric; Strickland, Pamela A Ohman; Mainelis, Gediminas; Lioy, Paul J; Tetley, Teresa D; Chung, Kian Fan; Zhang, Junfeng; Ryan, Mary; Porter, Alex; Schwander, Stephan

    2014-01-01

    Acting as fuel combustion catalysts to increase fuel economy, cerium dioxide (ceria, CeO2) nanoparticles have been used in Europe as diesel fuel additives (Envirox™). We attempted to examine the effects of particles emitted from a diesel engine burning either diesel (diesel exhaust particles, DEP) or diesel doped with various concentrations of CeO2 (DEP-Env) on innate immune responses in THP-1 and primary human peripheral blood mononuclear cells (PBMC). Batches of DEP and DEP-Env were obtained on three separate occasions using identical collection and extraction protocols with the aim of determining the reproducibility of particles generated at different times. However, we observed significant differences in size and surface charge (zeta potential) of the DEP and DEP-Env across the three batches. We also observed that exposure of THP-1 cells and PBMC to identical concentrations of DEP and DEP-Env from the three batches resulted in statistically significant differences in bioreactivity as determined by IL-1β, TNF-α, IL-6, IFN-γ, and IL-12p40 mRNA (by qRT-PCR) and protein expression (by ELISPOT assays). Importantly, bioreactivity was noted in very tight ranges of DEP size (60 to 120 nm) and zeta potential (-37 to -41 mV). Thus, these physical properties of DEP and DEP-Env were found to be the primary determinants of the bioreactivity measured in this study. Our findings also point to the potential risk of over- or under- estimation of expected bioreactivity effects (and by inference of public health risks) from bulk DEP use without taking into account potential batch-to-batch variations in physical (and possibly chemical) properties.

  17. Variability in Bioreactivity Linked to Changes in Size and Zeta Potential of Diesel Exhaust Particles in Human Immune Cells

    PubMed Central

    Sarkar, Srijata; Zhang, Lin; Subramaniam, Prasad; Lee, Ki-Bum; Garfunkel, Eric; Strickland, Pamela A. Ohman.; Mainelis, Gediminas; Lioy, Paul J.; Tetley, Teresa D.; Chung, Kian Fan; Zhang, Junfeng; Ryan, Mary; Porter, Alex; Schwander, Stephan

    2014-01-01

    Acting as fuel combustion catalysts to increase fuel economy, cerium dioxide (ceria, CeO2) nanoparticles have been used in Europe as diesel fuel additives (Envirox™). We attempted to examine the effects of particles emitted from a diesel engine burning either diesel (diesel exhaust particles, DEP) or diesel doped with various concentrations of CeO2 (DEP-Env) on innate immune responses in THP-1 and primary human peripheral blood mononuclear cells (PBMC). Batches of DEP and DEP-Env were obtained on three separate occasions using identical collection and extraction protocols with the aim of determining the reproducibility of particles generated at different times. However, we observed significant differences in size and surface charge (zeta potential) of the DEP and DEP-Env across the three batches. We also observed that exposure of THP-1 cells and PBMC to identical concentrations of DEP and DEP-Env from the three batches resulted in statistically significant differences in bioreactivity as determined by IL-1β, TNF-α, IL-6, IFN-γ, and IL-12p40 mRNA (by qRT-PCR) and protein expression (by ELISPOT assays). Importantly, bioreactivity was noted in very tight ranges of DEP size (60 to 120 nm) and zeta potential (−37 to −41 mV). Thus, these physical properties of DEP and DEP-Env were found to be the primary determinants of the bioreactivity measured in this study. Our findings also point to the potential risk of over- or under- estimation of expected bioreactivity effects (and by inference of public health risks) from bulk DEP use without taking into account potential batch-to-batch variations in physical (and possibly chemical) properties. PMID:24825358

  18. Magneto-optical absorption in semiconducting spherical quantum dots: Influence of the dot-size, confining potential, and magnetic field

    SciTech Connect

    Kushwaha, Manvir S.

    2014-12-15

    Semiconducting quantum dots – more fancifully dubbed artificial atoms – are quasi-zero dimensional, tiny, man-made systems with charge carriers completely confined in all three dimensions. The scientific quest behind the synthesis of quantum dots is to create and control future electronic and optical nanostructures engineered through tailoring size, shape, and composition. The complete confinement – or the lack of any degree of freedom for the electrons (and/or holes) – in quantum dots limits the exploration of spatially localized elementary excitations such as plasmons to direct rather than reciprocal space. Here we embark on a thorough investigation of the magneto-optical absorption in semiconducting spherical quantum dots characterized by a confining harmonic potential and an applied magnetic field in the symmetric gauge. This is done within the framework of Bohm-Pines’ random-phase approximation that enables us to derive and discuss the full Dyson equation that takes proper account of the Coulomb interactions. As an application of our theoretical strategy, we compute various single-particle and many-particle phenomena such as the Fock-Darwin spectrum; Fermi energy; magneto-optical transitions; probability distribution; and the magneto-optical absorption in the quantum dots. It is observed that the role of an applied magnetic field on the absorption spectrum is comparable to that of a confining potential. Increasing (decreasing) the strength of the magnetic field or the confining potential is found to be analogous to shrinking (expanding) the size of the quantum dots: resulting into a blue (red) shift in the absorption spectrum. The Fermi energy diminishes with both increasing magnetic-field and dot-size; and exhibits saw-tooth-like oscillations at large values of field or dot-size. Unlike laterally confined quantum dots, both (upper and lower) magneto-optical transitions survive even in the extreme instances. However, the intra-Landau level

  19. Magneto-optical absorption in semiconducting spherical quantum dots: Influence of the dot-size, confining potential, and magnetic field

    NASA Astrophysics Data System (ADS)

    Kushwaha, Manvir S.

    2014-12-01

    Semiconducting quantum dots - more fancifully dubbed artificial atoms - are quasi-zero dimensional, tiny, man-made systems with charge carriers completely confined in all three dimensions. The scientific quest behind the synthesis of quantum dots is to create and control future electronic and optical nanostructures engineered through tailoring size, shape, and composition. The complete confinement - or the lack of any degree of freedom for the electrons (and/or holes) - in quantum dots limits the exploration of spatially localized elementary excitations such as plasmons to direct rather than reciprocal space. Here we embark on a thorough investigation of the magneto-optical absorption in semiconducting spherical quantum dots characterized by a confining harmonic potential and an applied magnetic field in the symmetric gauge. This is done within the framework of Bohm-Pines' random-phase approximation that enables us to derive and discuss the full Dyson equation that takes proper account of the Coulomb interactions. As an application of our theoretical strategy, we compute various single-particle and many-particle phenomena such as the Fock-Darwin spectrum; Fermi energy; magneto-optical transitions; probability distribution; and the magneto-optical absorption in the quantum dots. It is observed that the role of an applied magnetic field on the absorption spectrum is comparable to that of a confining potential. Increasing (decreasing) the strength of the magnetic field or the confining potential is found to be analogous to shrinking (expanding) the size of the quantum dots: resulting into a blue (red) shift in the absorption spectrum. The Fermi energy diminishes with both increasing magnetic-field and dot-size; and exhibits saw-tooth-like oscillations at large values of field or dot-size. Unlike laterally confined quantum dots, both (upper and lower) magneto-optical transitions survive even in the extreme instances. However, the intra-Landau level transitions are seen

  20. The Isolation of DNA by Polycharged Magnetic Particles: An Analysis of the Interaction by Zeta Potential and Particle Size

    PubMed Central

    Haddad, Yazan; Xhaxhiu, Kledi; Kopel, Pavel; Hynek, David; Zitka, Ondrej; Adam, Vojtech

    2016-01-01

    Magnetic isolation of biological targets is in major demand in the biotechnology industry today. This study considers the interaction of four surface-modified magnetic micro- and nanoparticles with selected DNA fragments. Different surface modifications of nanomaghemite precursors were investigated: MAN37 (silica-coated), MAN127 (polyvinylpyrrolidone-coated), MAN158 (phosphate-coated), and MAN164 (tripolyphosphate-coated). All particles were positive polycharged agglomerated monodispersed systems. Mean particle sizes were 0.48, 2.97, 2.93, and 3.67 μm for MAN37, MAN127, MAN164, and MAN158, respectively. DNA fragments exhibited negative zeta potential of −0.22 mV under binding conditions (high ionic strength, low pH, and dehydration). A decrease in zeta potential of particles upon exposure to DNA was observed with exception of MAN158 particles. The measured particle size of MAN164 particles increased by nearly twofold upon exposure to DNA. Quantitative PCR isolation of DNA with a high retrieval rate was observed by magnetic particles MAN127 and MAN164. Interaction between polycharged magnetic particles and DNA is mediated by various binding mechanisms such as hydrophobic and electrostatic interactions. Future development of DNA isolation technology requires an understanding of the physical and biochemical conditions of this process. PMID:27104527

  1. The Isolation of DNA by Polycharged Magnetic Particles: An Analysis of the Interaction by Zeta Potential and Particle Size.

    PubMed

    Haddad, Yazan; Xhaxhiu, Kledi; Kopel, Pavel; Hynek, David; Zitka, Ondrej; Adam, Vojtech

    2016-04-20

    Magnetic isolation of biological targets is in major demand in the biotechnology industry today. This study considers the interaction of four surface-modified magnetic micro- and nanoparticles with selected DNA fragments. Different surface modifications of nanomaghemite precursors were investigated: MAN37 (silica-coated), MAN127 (polyvinylpyrrolidone-coated), MAN158 (phosphate-coated), and MAN164 (tripolyphosphate-coated). All particles were positive polycharged agglomerated monodispersed systems. Mean particle sizes were 0.48, 2.97, 2.93, and 3.67 μm for MAN37, MAN127, MAN164, and MAN158, respectively. DNA fragments exhibited negative zeta potential of -0.22 mV under binding conditions (high ionic strength, low pH, and dehydration). A decrease in zeta potential of particles upon exposure to DNA was observed with exception of MAN158 particles. The measured particle size of MAN164 particles increased by nearly twofold upon exposure to DNA. Quantitative PCR isolation of DNA with a high retrieval rate was observed by magnetic particles MAN127 and MAN164. Interaction between polycharged magnetic particles and DNA is mediated by various binding mechanisms such as hydrophobic and electrostatic interactions. Future development of DNA isolation technology requires an understanding of the physical and biochemical conditions of this process.

  2. Energy storage for the electricity grid : benefits and market potential assessment guide : a study for the DOE Energy Storage Systems Program.

    SciTech Connect

    Eyer, James M.; Corey, Garth P.

    2010-02-01

    This guide describes a high-level, technology-neutral framework for assessing potential benefits from and economic market potential for energy storage used for electric-utility-related applications. The overarching theme addressed is the concept of combining applications/benefits into attractive value propositions that include use of energy storage, possibly including distributed and/or modular systems. Other topics addressed include: high-level estimates of application-specific lifecycle benefit (10 years) in $/kW and maximum market potential (10 years) in MW. Combined, these criteria indicate the economic potential (in $Millions) for a given energy storage application/benefit. The benefits and value propositions characterized provide an important indication of storage system cost targets for system and subsystem developers, vendors, and prospective users. Maximum market potential estimates provide developers, vendors, and energy policymakers with an indication of the upper bound of the potential demand for storage. The combination of the value of an individual benefit (in $/kW) and the corresponding maximum market potential estimate (in MW) indicates the possible impact that storage could have on the U.S. economy. The intended audience for this document includes persons or organizations needing a framework for making first-cut or high-level estimates of benefits for a specific storage project and/or those seeking a high-level estimate of viable price points and/or maximum market potential for their products. Thus, the intended audience includes: electric utility planners, electricity end users, non-utility electric energy and electric services providers, electric utility regulators and policymakers, intermittent renewables advocates and developers, Smart Grid advocates and developers, storage technology and project developers, and energy storage advocates.

  3. Finding Alternatives to the Dogma of Power Based Sample Size Calculation: Is a Fixed Sample Size Prospective Meta-Experiment a Potential Alternative?

    PubMed Central

    Tavernier, Elsa; Trinquart, Ludovic; Giraudeau, Bruno

    2016-01-01

    Sample sizes for randomized controlled trials are typically based on power calculations. They require us to specify values for parameters such as the treatment effect, which is often difficult because we lack sufficient prior information. The objective of this paper is to provide an alternative design which circumvents the need for sample size calculation. In a simulation study, we compared a meta-experiment approach to the classical approach to assess treatment efficacy. The meta-experiment approach involves use of meta-analyzed results from 3 randomized trials of fixed sample size, 100 subjects. The classical approach involves a single randomized trial with the sample size calculated on the basis of an a priori-formulated hypothesis. For the sample size calculation in the classical approach, we used observed articles to characterize errors made on the formulated hypothesis. A prospective meta-analysis of data from trials of fixed sample size provided the same precision, power and type I error rate, on average, as the classical approach. The meta-experiment approach may provide an alternative design which does not require a sample size calculation and addresses the essential need for study replication; results may have greater external validity. PMID:27362939

  4. Marketed Drugs Can Inhibit Cytochrome P450 27A1, a Potential New Target for Breast Cancer Adjuvant Therapy.

    PubMed

    Mast, Natalia; Lin, Joseph B; Pikuleva, Irina A

    2015-09-01

    Cytochrome P450 CYP27A1 is the only enzyme in humans converting cholesterol to 27-hydroxycholesterol, an oxysterol of multiple functions, including tissue-specific modulation of estrogen and liver X receptors. Both receptors seem to mediate adverse effects of 27-hydroxycholesterol in breast cancer when the levels of this oxysterol are elevated. The present work assessed druggability of CYP27A1 as a potential antibreast cancer target. We selected 26 anticancer and noncancer medications, most approved by the Food and Drug Administration, and evaluated them first in vitro for inhibition of purified recombinant CYP27A1 and binding to the enzyme active site. Six strong CYP27A1 inhibitors/binders were identified. These were the two antibreast cancer pharmaceuticals anastrozole and fadrozole, antiprostate cancer drug bicalutamide, sedative dexmedetomidine, and two antifungals ravuconazole and posaconazole. Anastrozole was then tested in vivo on mice, which received subcutaneous drug injections for 1 week. Mouse plasma and hepatic 27-hydroxycholesterol levels were decreased 2.6- and 1.6-fold, respectively, whereas plasma and hepatic cholesterol content remained unchanged. Thus, pharmacologic CYP27A1 inhibition is possible in the whole body and individual organs, but does not negatively affect cholesterol elimination. Our results enhance the potential of CYP27A1 as an antibreast cancer target, could be of importance for the interpretation of Femara versus Anastrozole Clinical Evaluation Trial, and bring attention to posaconazole as a potential complementary anti-breast cancer medication. More medications on the US market may have unanticipated off-target inhibition of CYP27A1, and we propose strategies for their identification.

  5. Marketed Drugs Can Inhibit Cytochrome P450 27A1, a Potential New Target for Breast Cancer Adjuvant Therapy

    PubMed Central

    Mast, Natalia; Lin, Joseph B.

    2015-01-01

    Cytochrome P450 CYP27A1 is the only enzyme in humans converting cholesterol to 27-hydroxycholesterol, an oxysterol of multiple functions, including tissue-specific modulation of estrogen and liver X receptors. Both receptors seem to mediate adverse effects of 27-hydroxycholesterol in breast cancer when the levels of this oxysterol are elevated. The present work assessed druggability of CYP27A1 as a potential antibreast cancer target. We selected 26 anticancer and noncancer medications, most approved by the Food and Drug Administration, and evaluated them first in vitro for inhibition of purified recombinant CYP27A1 and binding to the enzyme active site. Six strong CYP27A1 inhibitors/binders were identified. These were the two antibreast cancer pharmaceuticals anastrozole and fadrozole, antiprostate cancer drug bicalutamide, sedative dexmedetomidine, and two antifungals ravuconazole and posaconazole. Anastrozole was then tested in vivo on mice, which received subcutaneous drug injections for 1 week. Mouse plasma and hepatic 27-hydroxycholesterol levels were decreased 2.6- and 1.6-fold, respectively, whereas plasma and hepatic cholesterol content remained unchanged. Thus, pharmacologic CYP27A1 inhibition is possible in the whole body and individual organs, but does not negatively affect cholesterol elimination. Our results enhance the potential of CYP27A1 as an antibreast cancer target, could be of importance for the interpretation of Femara versus Anastrozole Clinical Evaluation Trial, and bring attention to posaconazole as a potential complementary anti-breast cancer medication. More medications on the US market may have unanticipated off-target inhibition of CYP27A1, and we propose strategies for their identification. PMID:26082378

  6. Intrinsic variability in Pv, RRP size, Ca(2+) channel repertoire, and presynaptic potentiation in individual synaptic boutons.

    PubMed

    Ariel, Pablo; Hoppa, Michael B; Ryan, Timothy A

    2012-01-01

    The strength of individual synaptic contacts is considered a key modulator of information flow across circuits. Presynaptically the strength can be parsed into two key parameters: the size of the readily releasable pool (RRP) and the probability that a vesicle in that pool will undergo exocytosis when an action potential fires (Pv). How these variables are controlled and the degree to which they vary across individual nerve terminals is crucial to understand synaptic plasticity within neural circuits. Here we report robust measurements of these parameters in rat hippocampal neurons and their variability across populations of individual synapses. We explore the diversity of presynaptic Ca(2+) channel repertoires and evaluate their effect on synaptic strength at single boutons. Finally, we study the degree to which synapses can be differentially modified by a known potentiator of presynaptic function, forskolin. Our experiments revealed that both Pv and RRP spanned a large range, even for synapses made by the same axon, demonstrating that presynaptic efficacy is governed locally at the single synapse level. Synapses varied greatly in their dependence on N or P/Q type Ca(2+) channels for neurotransmission, but there was no association between specific channel repertoires and synaptic efficacy. Increasing cAMP concentration using forskolin enhanced synaptic transmission in a Ca(2+)-independent manner that was inversely related with a synapse's initial Pv, and independent of its RRP size. We propose a simple model based on the relationship between Pv and calcium entry that can account for the variable potentiation of synapses based on initial probability of vesicle fusion.

  7. Potential of ultrafiltration for organic matter removal in the polymer industry effluent based on particle size distribution analysis.

    PubMed

    Doğruel, Serdar; Çokgör, Emine Ubay; Ince, Orhan; Sözen, Seval; Orhon, Derin

    2013-01-01

    The purpose of the study was the experimental evaluation of ultrafiltration as a potential innovative technology for the removal of organic matter of around 15,000 mg chemical oxygen demand (COD) per liter in the polymer industry wastewater. Particle size distribution (PSD) analysis served as the major experimental instrument along with conventional chemical settling. Biodegradation characteristics of the remaining COD after ultrafiltration were determined by model interpretation of the corresponding oxygen uptake rate (OUR) profile. The study first involved a detailed characterization of the polymer wastewater including PSD analysis of the COD content. Chemical treatability was investigated using lime alone and with ferric chloride as coagulants followed with a PSD assessment of the chemically settled effluent. Modeling of the OUR profile generated by the ultrafiltration effluent defined related biodegradation kinetics and provided information on the overall COD removal potential. PSD analysis indicated that more than 70 % of the total COD accumulated in the 220- to 450-nm size range. It indicated that ultrafiltration was potentially capable of removing more than 90 % of the COD with an effluent lower than 1,500 mg COD/L. Chemical settling with 750 mg/L of FeCl(3) dosing at a pH of 7.0 provided a similar performance. The ultrafiltration effluent included mainly hydrolysable COD and proved to be biodegradable, with the process kinetics compatible with domestic sewage. PSD evaluation proved to be a valuable scientific instrument for underlining the merit of ultrafiltration as the appropriate innovative technology for polymer wastewater, removing the major portion of the COD in a way that is suitable for recovery and reuse and producing a totally biodegradable effluent.

  8. Potential for the development of a marketing option for the specialty local Ban pork of a Thai ethnic smallholder cooperative group in Northwest Vietnam.

    PubMed

    Le, Thi Thanh Huyen; Muth, Philipp C; Markemann, André; Schöll, Kerstin; Zárate, Anne Valle

    2016-02-01

    Based on 12 years of research (SFB 564 "The Uplands Program"), a community-based breeding and marketing cooperative group was transferred to an ethnic farmer group. This study analyses the potential for developing a marketing channel for specialty local Ban pork as an alternative to supplying the local markets to ensure long-term sustainability of the communal local pig breeding and production system. Data on pig-keeping were investigated from 378 farmers who wanted to enroll in the cooperative group in 10 villages (near town, intermediate, and remote zones) in Son La province. The data on Ban pig marketing activities of the cooperative group were investigated for all of its 180 members. Information on the market demand for Ban pigs were collected by interviewing 57 traders in Hanoi city and Son La province. The results show a dominance of local Ban in remote areas, and a preference for crossbreds with exotics in closer-to-town areas. Before farmers joined the cooperative group, the commercialization of pigs in remote villages accounted for only 3.0 pigs/farm/year compared to 9.3 pigs/farm/year in the intermediate zone and 11.2 pigs/farm/year near town. Potential markets have been identified for each product category of the cooperative group. Pure Ban pigs with a weight of 10-15 kg were preferred most by customers in Hanoi city. The regular feedback of information on niche markets for different products has increased the awareness of farmers about the competitiveness of the local pig products, and the power of collective action in the market. Selected pure Ban pigs were increasingly sold to food stores in Hanoi with high prices. Farmers received an average of 9000 VND more compared to the local market price for each kg of live weight. The respective added value for the cooperative group amounted to 11,300 VND/kg live weight. The added value from selling specialty Ban pigs regularly to markets, encouraged farmers toward a market in local pig production and

  9. Potential environmental influences on variation in body size and sexual size dimorphism among Arizona populations of the western diamond-backed rattlesnake (Crotalus atrox)

    USGS Publications Warehouse

    Amarello, Melissa; Nowak, Erica M.; Taylor, Emily N.; Schuett, Gordon W.; Repp, Roger A.; Rosen, Philip C.; Hardy, David L.

    2010-01-01

    Differences in resource availability and quality along environmental gradients are important influences contributing to intraspecific variation in body size, which influences numerous life-history traits. Here, we examined variation in body size and sexual size dimorphism (SSD) in relation to temperature, seasonality, and precipitation among 10 populations located throughout Arizona of the western diamond-backed rattlesnake (Crotalus atrox). Specifically, in our analyses we addressed the following questions: (i) Are adult males larger in cooler, wetter areas? (ii) Does female body size respond differently to environmental variation? (iii) Is seasonality a better predictor of body size variation? (iv) Is SSD positively correlated with increased resources? We demonstrate that male and female C. atrox are larger in body size in cooler (i.e., lower average annual maximum, minimum, and mean temperature) and wetter areas (i.e., higher average annual precipitation, more variable precipitation, and available surface water). Although SSD in C. atrox appeared to be more pronounced in cooler, wetter areas, this relationship did not achieve statistical significance.

  10. The Metaboloepigenetic Dimension of Cancer Stem Cells: Evaluating the Market Potential for New Metabostemness-Targeting Oncology Drugs.

    PubMed

    Menendez, Javier A

    2015-01-01

    The current global portfolio of oncology drugs is unlikely to produce durable disease remission for millions of cancer patients worldwide. This is due, in part, to the existence of so-called cancer stem cells (CSCs), a particularly aggressive type of malignant cell that is capable of indefinite self-replication, is refractory to conventional treatments, and is skilled at spreading and colonizing distant organs. To date, no drugs from big-league Pharma companies are capable of killing CSCs. Why? Quite simply, a classic drug development approach based on mutated genes and pathological protein products cannot efficiently target the plastic, epigenetic proclivity of cancer tissues to generate CSCs. Recent studies have proposed that certain elite metabolites (oncometabolites) and other common metabolites can significantly influence the establishment and maintenance of epigenetic signatures of stemness and cancer. Consequently, cellular metabolism and the core epigenetic codes, DNA methylation and histone modification, can be better viewed as an integrated metaboloepigenetic dimension of CSCs, which we have recently termed cancer metabostemness. By targeting weaknesses in the bridge connecting metabolism and epigenetics, a new generation of metabostemnessspecific drugs can be generated for potent and long-lasting elimination of life-threatening CSCs. Here I evaluate the market potential of re-modeling the oncology drug pipeline by discovering and developing new metabolic approaches able to target the apparently undruggable epigenetic programs that dynamically regulate the plasticity of non-CSC and CSC cellular states.

  11. Degradation and osteogenic potential of a novel poly(lactic acid)/nano-sized β-tricalcium phosphate scaffold.

    PubMed

    Cao, Lu; Duan, Ping-Guo; Wang, Hui-Ren; Li, Xi-Lei; Yuan, Feng-Lai; Fan, Zhong-Yong; Li, Su-Ming; Dong, Jian

    2012-01-01

    The purpose of this study was to investigate the influence of nano-sized β-tricalcium phosphate (β-TCP) on the biological performance of poly (lactic acid) (PLA) composite scaffolds by using in vitro degradation and an in vivo model of heterotopic bone formation. Nano-sized β-TCP (nβ-TCP) was prepared with a wet grinding method from micro-sized β-TCP (mβ-TCP), and composite scaffolds containing 0, 10, 30, or 50 wt% nβ-TCP or 30 wt% mβ-TCP were generated using a freeze-drying method. Degradation was assessed by monitoring changes in microstructure, pH, weight, and compressive strength over a 26-week period of hydrolysis. Composite scaffolds were processed into blocks, and implanted into muscular pockets of rabbits after loading with recombinant human bone morphogenetic protein-2 (rhBMP-2). New bone formation was evaluated based on histological and immunohistochemical analysis 2, 4, and 8 weeks after implantation. The in vitro results indicated that the buffering effect of nβ-TCP was stronger than mβ-TCP, which was positively correlated with the content of nβ-TCP. The in vivo findings demonstrated that nβ-TCP enhanced the osteoconductivity of the scaffolds. Although composite scaffolds containing 30% nβ-TCP exhibited similar osteoconductivity to 50% nβ-TCP, they had better mechanical properties than the 50% nβ-TCP scaffolds. This study supports the potential application of a composite scaffold containing 30% nβ-TCP as a promising scaffold for bone regeneration.

  12. Accelerating potential of mean force calculations for lipid membrane permeation: System size, reaction coordinate, solute-solute distance, and cutoffs

    NASA Astrophysics Data System (ADS)

    Nitschke, Naomi; Atkovska, Kalina; Hub, Jochen S.

    2016-09-01

    Molecular dynamics simulations are capable of predicting the permeability of lipid membranes for drug-like solutes, but the calculations have remained prohibitively expensive for high-throughput studies. Here, we analyze simple measures for accelerating potential of mean force (PMF) calculations of membrane permeation, namely, (i) using smaller simulation systems, (ii) simulating multiple solutes per system, and (iii) using shorter cutoffs for the Lennard-Jones interactions. We find that PMFs for membrane permeation are remarkably robust against alterations of such parameters, suggesting that accurate PMF calculations are possible at strongly reduced computational cost. In addition, we evaluated the influence of the definition of the membrane center of mass (COM), used to define the transmembrane reaction coordinate. Membrane-COM definitions based on all lipid atoms lead to artifacts due to undulations and, consequently, to PMFs dependent on membrane size. In contrast, COM definitions based on a cylinder around the solute lead to size-independent PMFs, down to systems of only 16 lipids per monolayer. In summary, compared to popular setups that simulate a single solute in a membrane of 128 lipids with a Lennard-Jones cutoff of 1.2 nm, the measures applied here yield a speedup in sampling by factor of ˜40, without reducing the accuracy of the calculated PMF.

  13. European Databanks on the March and The U.S.A. as a Potential Market for British Information Products.

    ERIC Educational Resources Information Center

    Provenzano, Dominic; And Others

    1987-01-01

    Detailed profiles and comparisons of European databanks being marketed in the United States include marketing strategies, subject content, number and types of databases offered, cost information, value added services, and more. Users' views of the viability, ease of use, and strengths and weaknesses of European databases are presented. (CLB)

  14. Mathematical and Computer Skills and Workplace Literacy in Labor Markets: An Analysis of Their Actual and Potential Effect on the Economic Status of Women. Final Report.

    ERIC Educational Resources Information Center

    Joel Popkin and Co., Washington, DC.

    Data from the Current Population Surveys of October 1984, October 1989, and January 1991 were used to examine the role of computer and mathematical skills in the U.S. labor market from 1984-91. Particular attention was given to their actual and potential effect on the economic status of women. Data confirmed the overall increase in the education…

  15. Potential enhanced ability of giant squid to detect sperm whales is an exaptation tied to their large body size.

    PubMed

    Schmitz, Lars; Motani, Ryosuke; Oufiero, Christopher E; Martin, Christopher H; McGee, Matthew D; Wainwright, Peter C

    2013-10-15

    It has been hypothesized that sperm whale predation is the driver of eye size evolution in giant squid. Given that the eyes of giant squid have the size expected for a squid this big, it is likely that any enhanced ability of giant squid to detect whales is an exaptation tied to their body size. Future studies should target the mechanism behind the evolution of large body size, not eye size. Reconstructions of the evolutionary history of selective regime, eye size, optical performance, and body size will improve the understanding of the evolution of large eyes in large ocean animals.

  16. Belimumab efficacy is 'mild' but market potential still great†: anticipating us approval of the first lupus drug since 1957.

    PubMed

    Weintraub, Ben

    2011-06-01

    Speaking for the inThought Expert Discussion Series in February, Dr George Tsokos mirrored the opinion of many lupus thought leaders: Human Genome Sciences (HGS) and GlaxoSmithKline's (GSK) belimumab (Benlysta®) was likely to be approved by the US FDA and, despite modest efficacy, will be used by a large proportion of lupus patients. Dr Tsokos praised HGS and GSK's clinical trial program for belimumab, noting that huge trials and unique trial endpoints were needed to demonstrate the drug's efficacy, allowing it to succeed where so many other lupus drugs have failed. Still, belimumab's trial design may not become standard in future lupus trials - questions about identification of appropriate lupus patients with active disease, trial endpoints, and subgrouping lupus patients remain. Although Dr Tsokos does not expect other agents currently being tested in lupus trials to be significantly more efficacious than belimumab, his research suggests that significantly better results could be obtained using agents targeting interleukin-17, spleen tyrosine kinase (SYK), and calcium/calmodulin-dependent protein kinase type IV (CaMKIV). In line with Dr Tsokos' comments and consistent with inThought's outlook for belimumab, the US FDA granted approval for belimumab in March 2011, making it the first new lupus drug to be approved in more than 50 years. inThought projects US sales of $1.1 billion for belimumab by 2017. † Adapted and reproduced from Weintraub B. Benlysta Efficacy is "Mild" but Market Potential Still Great: Anticipating U.S. Approval of the First Lupus Drug Since 1957. inThought Research, 2011 Feb 24.

  17. Predicting Consumer Biomass, Size-Structure, Production, Catch Potential, Responses to Fishing and Associated Uncertainties in the World's Marine Ecosystems.

    PubMed

    Jennings, Simon; Collingridge, Kate

    2015-01-01

    Existing estimates of fish and consumer biomass in the world's oceans are disparate. This creates uncertainty about the roles of fish and other consumers in biogeochemical cycles and ecosystem processes, the extent of human and environmental impacts and fishery potential. We develop and use a size-based macroecological model to assess the effects of parameter uncertainty on predicted consumer biomass, production and distribution. Resulting uncertainty is large (e.g. median global biomass 4.9 billion tonnes for consumers weighing 1 g to 1000 kg; 50% uncertainty intervals of 2 to 10.4 billion tonnes; 90% uncertainty intervals of 0.3 to 26.1 billion tonnes) and driven primarily by uncertainty in trophic transfer efficiency and its relationship with predator-prey body mass ratios. Even the upper uncertainty intervals for global predictions of consumer biomass demonstrate the remarkable scarcity of marine consumers, with less than one part in 30 million by volume of the global oceans comprising tissue of macroscopic animals. Thus the apparently high densities of marine life seen in surface and coastal waters and frequently visited abundance hotspots will likely give many in society a false impression of the abundance of marine animals. Unexploited baseline biomass predictions from the simple macroecological model were used to calibrate a more complex size- and trait-based model to estimate fisheries yield and impacts. Yields are highly dependent on baseline biomass and fisheries selectivity. Predicted global sustainable fisheries yield increases ≈4 fold when smaller individuals (< 20 cm from species of maximum mass < 1 kg) are targeted in all oceans, but the predicted yields would rarely be accessible in practice and this fishing strategy leads to the collapse of larger species if fishing mortality rates on different size classes cannot be decoupled. Our analyses show that models with minimal parameter demands that are based on a few established ecological principles

  18. The Longview/Lakeview Barite Deposits, Southern National Petroleum Reserve, Alaska (NPRA) - Potential-Field Models and Preliminary Size Estimates

    USGS Publications Warehouse

    Schmidt, Jeanine M.; Glen, Jonathan M.G.; Morin, Robert L.

    2009-01-01

    Longview and Lakeview are two of the larger stratiform barite deposits hosted in Mississippian Akmalik Chert in the Cutaway Basin area (Howard Pass C-3 quadrangle) of the southern National Petroleum Reserve, Alaska (NPRA). Geologic studies for the South NPRA Integrated Activity Plan and Environmental Impact Statement process included an attempt to evaluate the possible size of barite resources at Longview and Lakeview by using potential-field geophysical methods (gravity and magnetics). Gravity data from 227 new stations measured by the U.S. Geological Survey, sparse regional gravity data, and new, high-resolution aeromagnetic data were forward modeled simultaneously along seven profiles perpendicular to strike and two profiles along strike of the Longview and Lakeview deposits. These models indicate details of the size and shape of the barite deposits and suggest thicknesses of 15 to 24 m, and 9 to 24 m for the Longview and Lakeview deposits, respectively. Two groups of outcrops span 1.8 km of strike length and are likely connected below the surface by barite as much as 10 m thick. Barite of significant thickness (>-5 m) is unlikely to occur north of the presently known exposures of the Longview deposit. The barite bodies have irregular (nonplanar) bases suggestive of folding; northwest-trending structures of small apparent offset cross strike at several locations. Dip of the barite is 10 to 25 degrees to the southeast. True width of the bodies (the least certain dimension) is estimated to be 160 to 200 m for Longview and 220 to 260 m for Lakeview. The two bodies contain a minimum of 4.5 million metric tons of barite and more than 38 million metric tons are possible. Grades of the barite are relatively high, with high specific gravities and low impurities. The potential for the Cutaway Basin to host economically minable quantities of barite is uncertain. Heavy-mineral concentrate samples from streams in the area, trace-element analyses, and physicalproperty

  19. Evaluating the potential impact of transmission constraints on the operation of a competitive electricity market in Illinois.

    SciTech Connect

    Cirillo, R.; Thimmapuram, P.; Veselka, T.; Koritarov, V.; Conzelmann, G.; Macal, C.; Boyd, G.; North, M.; Overbye, T.; Cheng, X.; Decision and Information Sciences; Univ. of Illinois

    2006-04-30

    Despite the current adequacy of the generation and transmission system in Illinois, there is concern that the uncertainties of electricity restructuring warrant a more detailed analysis to determine if there might be pitfalls that have not been identified under current conditions. The problems experienced elsewhere in the country emphasize the need for an evaluation of how Illinois might fare under a restructured electricity market. The Illinois Commerce Commission (ICC) commissioned this study to be undertaken as a joint effort by the University of Illinois at Urbana-Champaign and Argonne National Laboratory to evaluate the Illinois situation in the 2007 period when restructuring is scheduled to be fully implemented in the State. The purpose of this study is to make an initial determination if the transmission system in Illinois and the surrounding region would be able to support a competitive electricity market, would allow for effective competition to keep prices in check, and would allow for new market participants to effectively compete for market share. The study seeks to identify conditions that could reasonably be expected to occur that would enable a company to exercise market power in one or more portions of the State and thereby create undue pressure on the prices charged to customers and/or inhibit new market participants from entering the market. The term 'market power' has many different definitions, and there is no universal agreement on how to measure it. For the purposes of this study, the term is defined as the ability to raise prices and increase profitability by unilateral action. A more complete definition is provided later. With this definition, the central question of this analysis becomes: 'Can a company, acting on its own, raise electricity prices and increase its profits?' It should be noted that the intent of the study is not to predict whether or not such market power would be exercised by any company. Rather, it is designed to determine

  20. Identifying live bird markets with the potential to act as reservoirs of avian influenza A (H5N1) virus: a survey in northern Viet Nam and Cambodia.

    PubMed

    Fournié, Guillaume; Guitian, Javier; Desvaux, Stéphanie; Mangtani, Punam; Ly, Sowath; Cong, Vu Chi; San, Sorn; Dung, Do Huu; Holl, Davun; Pfeiffer, Dirk U; Vong, Sirenda; Ghani, Azra C

    2012-01-01

    Wet markets are common in many parts of the world and may promote the emergence, spread and maintenance of livestock pathogens, including zoonoses. A survey was conducted in order to assess the potential of Vietnamese and Cambodian live bird markets (LBMs) to sustain circulation of highly pathogenic avian influenza virus subtype H5N1 (HPAIV H5N1). Thirty Vietnamese and 8 Cambodian LBMs were visited, and structured interviews were conducted with the market managers and 561 Vietnamese and 84 Cambodian traders. Multivariate and cluster analysis were used to construct a typology of traders based on their poultry management practices. As a result of those practices and large poultry surplus (unsold poultry reoffered for sale the following day), some poultry traders were shown to promote conditions favorable for perpetuating HPAIV H5N1 in LBMs. More than 80% of these traders operated in LBMs located in the most densely populated areas, Ha Noi and Phnom Penh. The profiles of sellers operating at a given LBM could be reliably predicted using basic information about the location and type of market. Consequently, LBMs with the largest combination of risk factors for becoming virus reservoirs could be easily identified, potentially allowing control strategies to be appropriately targeted. These findings are of particular relevance to resource-scarce settings with extensively developed LBM systems, commonly found in South-East Asia.

  1. “And they told two friends…and so on”: RJ Reynolds’ viral marketing of Eclipse and its potential to mislead the public

    PubMed Central

    Anderson, S J; Ling, P M

    2010-01-01

    Objective To explore viral marketing strategies for Eclipse cigarettes used by the RJ Reynolds Company (Winston-Salem, North Carolina, USA). Methods Analysis of previously secret tobacco industry documents and multimedia materials. Results The failure of RJ Reynolds’ (RJR) 1988 “smokeless” cigarette, Premier, was in part due to widespread bad word of mouth about the product’s flavour, quality and difficulty of use. In 1994 RJR introduced an updated version of Premier, the ostensibly “reduced risk” Eclipse cigarette. RJR developed viral marketing channels to promote Eclipse using (1) exploratory interviews to motivate consumers to spread the word about Eclipse prior to market release, (2) promotional videos featuring positive feedback from test group participants to portray majority consensus among triers, (3) “Tupperware”-like parties for Eclipse where participants received samples to pass around in their social circles and (4) the Eclipse website’s bulletin board as a forum for potential users to discuss the brand in their own words. These strategies targeted the brand’s likeliest adopters, recruited informal and credible representatives of the product unaffiliated with RJR, and controlled the information spread about the product. Conclusions Viral marketing techniques may be particularly useful to promote new tobacco products such as Eclipse that have limited appeal and need a highly motivated audience of early adopters and acceptors. Such techniques help evade the mass rejection that could follow mass promotion, circumvent marketing restrictions, and allow tobacco companies to benefit from health claims made by consumers. Cigarette manufacturers must be held accountable for perceived health benefits encouraged by all promotional activities including viral marketing. PMID:18332064

  2. Facile fabrication of uniform size-controlled microparticles and potentiality for tandem drug delivery system of micro/nanoparticles.

    PubMed

    Iwanaga, Shintaroh; Saito, Noriaki; Sanae, Hidetoshi; Nakamura, Makoto

    2013-09-01

    This article describes a rapid and facile method for manufacturing various size-controlled gel particles with utilizing inkjet printing technology. Generally, the size of droplets could be controlled by changing nozzle heads of inkjet printer, from which ink solution is ejected. However, this method uses drying process before gelling microparticles, and with that, the size of microparticles was easily controlled by only altering the concentration of ejected solution. When sodium alginate solution with various concentrations was ejected from inkjet printer, we found that the concentration of alginate solution vs. the volume of dried alginate particle showed an almost linear relationship in the concentration range from 0.1 to 3.0%. After dried alginate particles were soaked into calcium chloride solution, the size of microgel beads were obtained almost without increasing their size. The microparticles including various sizes of nanoparticles were easily manufactured by ejecting nanoparticle-dispersed alginate solution. The release of 25-nm sized nanoparticles from alginate microgel beads was finished in a relatively-rapid manner, whereas 100-nm sized nanoparticles were partially released from those ones. Moreover, most of 250-nm sized nanoparticles were not released from alginate microgel beads even after 24-h soaking. This particle fabricating method would enable the tandem drug delivery system with a combination of the release from nano and microparticles, and be expected for the biological and tissue engineering application.

  3. Market study: Biological isolation garment

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The biological isolation garment was originally designed for Apollo astronauts to wear upon their return to earth from the moon to avoid the possibility of their contaminating the environment. The concept has been adapted for medical use to protect certain patients from environmental contamination and the risk of infection. The nature and size of the anticipated market are examined with certain findings and conclusions relative to clinical acceptability and potential commercial viability of the biological isolation garment.

  4. Characterization and Potential Environmental Implications of Select Cu-Based Fungicides and Bactericides Employed in U.S. Markets

    EPA Science Inventory

    This exploratory study aimed to examine the extent and mineral speciation of nanosized Cu in two fungicide products (A and B) available in the U.S. markets. Electron microcopy results demonstrated the presence of spherical and polydisperse <100 nm Cu particles in product B. Oth...

  5. Market assessment overview

    NASA Technical Reports Server (NTRS)

    Habib-Agahi, H.

    1981-01-01

    Market assessment, refined with analysis disaggregated from a national level to the regional level and to specific market applications, resulted in more accurate and detailed market estimates. The development of an integrated set of computer simulations, coupled with refined market data, allowed progress in the ability to evaluate the worth of solar thermal parabolic dish systems. In-depth analyses of both electric and thermal market applications of these systems are described. The following market assessment studies were undertaken: (1) regional analysis of the near term market for parabolic dish systems; (2) potential early market estimate for electric applications; (3) potential early market estimate for industrial process heat/cogeneration applications; and (4) selection of thermal and electric application case studies for fiscal year 1981.

  6. The potential impacts of a competitive wholesale market in the midwest: A preliminary examination of centralized dispatch

    SciTech Connect

    Lesieutre, Bernard C.; Bartholomew, Emily; Eto, Joseph H.; Hale, Douglas; Luong, Thanh

    2004-07-01

    In March 2005, the Midwest Independent System Operator (MISO) will begin operating the first-ever wholesale market for electricity in the central and upper Midwestern portion of the United States. Region-wide, centralized, security-constrained, bid-based dispatch will replace the current system of decentralized dispatch by individual utilities and control areas. This report focuses on how the operation of generators may change under centralized dispatch. We analyze a stylized example of these changes by comparing a base case dispatch based on a ''snapshot'' taken from MISO's state estimator for an actual, historical dispatch (4 p.m., July 7, 2003) to a hypothetical, centralized dispatch that seeks to minimize the total system cost of production, using estimated cost data collected by the EIA. Based on these changes in dispatch, we calculate locational marginal prices, which in turn reveals the location of congestion within MISO's footprint, as well as the distribution of congestion revenues. We also consider two sensitivity scenarios that examine (1) the effect of changes in MISO membership (2003 vs. 2004 membership lists), and (2) different load and electrical data, based on a snapshot from a different date and time (1 p.m., Feb. 18, 2004). Although our analysis offers important insights into how the MISO market could operate when it opens, we do not address the question of the total benefits or costs of creating a wholesale market in the Midwest.

  7. DOE/NASA SIMS Prototype Solar System, no. 4. Part 1: Market analysis. Part 2: Modular manufacturing cost estimate

    NASA Technical Reports Server (NTRS)

    1979-01-01

    The findings of the IIT Research Institute (IITRI) market study of the SIMS Prototype System 4, a hot water (DHW) system are documented. The feasibility of prepackaging currently available solar heating components into modular subsystems for site assembly is addressed. A documented design and installation procedure and a performance test report were prepared. The potential markets and applications for this particular system in the nonfederal market are profiled by assessing the needs and requirements of potential users and specifiers, by characterizing the nature of the market and the competitive environment, by identifying the barriers to commercial acceptance, and by estimating the size of the potential market.

  8. [Body size, ecological tolerance and potential for water quality bioindication in the genus Anacroneuria (Plecoptera: Perlidae) from South America].

    PubMed

    Tomanova, Sylvie; Tedesco, Pablo A

    2007-03-01

    Knowledge about the biology and ecology of neotropical aquatic taxa is crucial to establish general ecological rules and water protection systems. Based mainly on published data, the present work shows the following biological and ecological characteristics of Anacroneuria species (Klapálek 1909): (a) the wide range of environmental conditions of rivers where Anacroneuria species occur, (b) species number decreases along an increasing elevation gradient, (c) body size increases in relation to the maximum altitude of occurrence, (d) altitudinal range increases with body size, (e) there is a constant relationship between male and female body size, and finally, (f) larger females lay larger eggs. In temperate countries, the family Perlidae in general, and the genus Anacroneuria in particular, are viewed as excellent water quality indicators. We suggest that, considering the complexity of the group's ecology in South America, it should not be automatically considered an excellent bioindicator in the Neotropical region.

  9. Regulation of Lipid Droplet Size in Mammary Epithelial Cells by Remodeling of Membrane Lipid Composition—A Potential Mechanism

    PubMed Central

    Cohen, Bat-Chen; Shamay, Avi; Argov-Argaman, Nurit

    2015-01-01

    Milk fat globule size is determined by the size of its precursors—intracellular lipid droplets—and is tightly associated with its composition. We examined the relationship between phospholipid composition of mammary epithelial cells and the size of both intracellular and secreted milk fat globules. Primary culture of mammary epithelial cells was cultured in medium without free fatty acids (control) or with 0.1 mM free capric, palmitic or oleic acid for 24 h. The amount and composition of the cellular lipids and the size of the lipid droplets were determined in the cells and medium. Mitochondrial quantity and expression levels of genes associated with mitochondrial biogenesis and polar lipid composition were determined. Cells cultured with oleic and palmitic acids contained similar quantities of triglycerides, 3.1- and 3.8-fold higher than in controls, respectively (P < 0.0001). When cultured with oleic acid, 22% of the cells contained large lipid droplets (>3 μm) and phosphatidylethanolamine concentration was higher by 23 and 63% compared with that in the control and palmitic acid treatments, respectively (P < 0.0001). In the presence of palmitic acid, only 4% of the cells contained large lipid droplets and the membrane phosphatidylcholine concentration was 22% and 16% higher than that in the control and oleic acid treatments, respectively (P < 0.0001). In the oleic acid treatment, approximately 40% of the lipid droplets were larger than 5 μm whereas in that of the palmitic acid treatment, only 16% of the droplets were in this size range. Triglyceride secretion in the oleic acid treatment was 2- and 12-fold higher compared with that in the palmitic acid and control treatments, respectively. Results imply that membrane composition of bovine mammary epithelial cells plays a role in controlling intracellular and secreted lipid droplets size, and that this process is not associated with cellular triglyceride content. PMID:25756421

  10. 77 FR 64311 - Potential Market Impact of the Proposed Fiscal Year 2014 Annual Materials Plan; National Defense...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-19

    ... effects of all acquisitions and disposals involving the stockpile and related material research and... domestic and foreign economic effects of all acquisitions and disposals of materials from the stockpile... lists the quantities and type of activity (potential acquisition, potential disposal, potential...

  11. Size-dependent characterisation of historical gold mine wastes to examine human pathways of exposure to arsenic and other potentially toxic elements.

    PubMed

    Martin, Rachael; Dowling, Kim; Pearce, Dora C; Florentine, Singarayer; Bennett, John W; Stopic, Attila

    2016-10-01

    Abandoned historical gold mining wastes often exist as geographically extensive, unremediated, and poorly contained deposits that contain elevated levels of As and other potentially toxic elements (PTEs). One of the key variables governing human exposure to PTEs in mine waste is particle size. By applying a size-resolved approach to mine waste characterisation, this study reports on the proportions of mine waste relevant to human exposure and mobility, as well as their corresponding PTE concentrations, in four distinct historical mine wastes from the gold province in Central Victoria, Australia. To the best of our knowledge, such a detailed investigation and comparison of historical mining wastes has not been conducted in this mining-affected region. Mass distribution analysis revealed notable proportions of waste material in the readily ingestible size fraction (≤250 µm; 36.1-75.6 %) and the dust size fraction (≤100 µm; 5.9-45.6 %), suggesting a high potential for human exposure and dust mobilisation. Common to all mine waste types were statistically significant inverse trends between particle size and levels of As and Zn. Enrichment of As in the finest investigated size fraction (≤53 µm) is of particular concern as these particles are highly susceptible to long-distance atmospheric transport. Human populations that reside in the prevailing wind direction from a mine waste deposit may be at risk of As exposure via inhalation and/or ingestion pathways. Enrichment of PTEs in the finer size fractions indicates that human health risk assessments based on bulk contaminant concentrations may underestimate potential exposure intensities.

  12. Cluster adjusted regression for displaced subject data (CARDS): Marginal inference under potentially informative temporal cluster size profiles.

    PubMed

    Bible, Joe; Beck, James D; Datta, Somnath

    2016-06-01

    Ignorance of the mechanisms responsible for the availability of information presents an unusual problem for analysts. It is often the case that the availability of information is dependent on the outcome. In the analysis of cluster data we say that a condition for informative cluster size (ICS) exists when the inference drawn from analysis of hypothetical balanced data varies from that of inference drawn on observed data. Much work has been done in order to address the analysis of clustered data with informative cluster size; examples include Inverse Probability Weighting (IPW), Cluster Weighted Generalized Estimating Equations (CWGEE), and Doubly Weighted Generalized Estimating Equations (DWGEE). When cluster size changes with time, i.e., the data set possess temporally varying cluster sizes (TVCS), these methods may produce biased inference for the underlying marginal distribution of interest. We propose a new marginalization that may be appropriate for addressing clustered longitudinal data with TVCS. The principal motivation for our present work is to analyze the periodontal data collected by Beck et al. (1997, Journal of Periodontal Research 6, 497-505). Longitudinal periodontal data often exhibits both ICS and TVCS as the number of teeth possessed by participants at the onset of study is not constant and teeth as well as individuals may be displaced throughout the study.

  13. Yeast and horse liver alcohol dehydrogenases: potential problems in target size analysis and evidence for a monomer active unit

    SciTech Connect

    Suarez, M.D.; Ferguson-Miller, S.

    1987-06-16

    Yeast and horse alcohol dehydrogenases are commonly used as standards for radiation inactivation analysis of proteins, usually assuming that the minimal functional unit corresponds to the physical size in solution, a tetramer (M/sub r/ = 148,000) and a dimer (M/sub r/ = 80,000), respectively. Results described in this paper demonstrate that molecular weight overestimates may be obtained for the yeast protein as a result of its unusual sensitivity to secondary radiation products. Irradiation in the presence of sulhydryl reagents results in a smaller functional size estimate (67,000 +/- 3000) than that obtained in their absence (128,000 +/- 5000), indicating that some sulfhydryl groups in the enzyme may be particularly susceptible to attack by radiolytic species. Analysis of the horse liver enzyme reveals that although it has structural and functional similarities to the yeast protein, it is not as prone to secondary radiation damage and gives a minimal functional size estimate (33,000 +/= 1000) that most closely corresponds to a monomer. Quantitation of disappearance of the protein from a sodium dodecyl sulfate gel as a function of radiation dose also gives a target size (48,000 +/- 3000) in reasonable agreement with the monomer molecular weight. These results indicate that the individual subunits of horse liver alcohol dehydrogenase have independent catalytic capacity and imply that the same may be true for the yeast enzyme.

  14. Development of size-customized hepatocarcinoma spheroids as a potential drug testing platform using a sacrificial gelatin microsphere system.

    PubMed

    Leong, Wenyan; Kremer, Antje; Wang, Dong-An

    2016-06-01

    Sacrificial gelatin microspheres can be developed as a cell delivery vehicle for non-anchorage dependent cells - its incorporation into a macroscopic scaffold system not only allows the cells to be cultured in suspension within cavities left behind by the sacrificial material, it also allows scaffold-free tissue development to be confined within the cavities. In this study, dense and highly viable hepatocarcinoma spheroids were developed by means of encapsulation in sacrificial gelatin microspheres produced via a simple water-in-oil emulsion technique. By initial selection of microsphere size and distribution, spheroid size can be controlled for various applications such as uniform tumor spheroids as a reproducible three-dimensional drug screening and testing platform that better mimics the in vivo nature of tumors (instead of conventional monolayer culture), as this study has suggested as a proof-of-concept with chemotherapy drug Doxorubicin.

  15. A General Class of Signed Rank Tests for Clustered Data when the Cluster Size is Potentially Informative.

    PubMed

    Datta, Somnath; Nevalainen, Jaakko; Oja, Hannu

    2012-09-01

    Rank based tests are alternatives to likelihood based tests popularized by their relative robustness and underlying elegant mathematical theory. There has been a serge in research activities in this area in recent years since a number of researchers are working to develop and extend rank based procedures to clustered dependent data which include situations with known correlation structures (e.g., as in mixed effects models) as well as more general form of dependence.The purpose of this paper is to test the symmetry of a marginal distribution under clustered data. However, unlike most other papers in the area, we consider the possibility that the cluster size is a random variable whose distribution is dependent on the distribution of the variable of interest within a cluster. This situation typically arises when the clusters are defined in a natural way (e.g., not controlled by the experimenter or statistician) and in which the size of the cluster may carry information about the distribution of data values within a cluster.Under the scenario of an informative cluster size, attempts to use some form of variance adjusted sign or signed rank tests would fail since they would not maintain the correct size under the distribution of marginal symmetry. To overcome this difficulty Datta and Satten (2008; Biometrics, 64, 501-507) proposed a Wilcoxon type signed rank test based on the principle of within cluster resampling. In this paper we study this problem in more generality by introducing a class of valid tests employing a general score function. Asymptotic null distribution of these tests is obtained. A simulation study shows that a more general choice of the score function can sometimes result in greater power than the Datta and Satten test; furthermore, this development offers the user a wider choice. We illustrate our tests using a real data example on spinal cord injury patients.

  16. Disruptions of stream sediment size and stability by lakes in mountain watersheds: Potential effects on periphyton biomass

    USGS Publications Warehouse

    Myers, A.K.; Marcarelli, A.M.; Arp, C.D.; Baker, M.A.; Wurtsbaugh, W.A.

    2007-01-01

    The location of a stream reach relative to other landforms in a watershed is an important attribute. We hypothesized that lakes disrupt the frequency of finer, more mobile sediments and thereby change sediment transport processes such that benthic substrates are more stable (i.e., less mobile) below lakes than above lakes. In turn, we hypothesized that this reduced mobility would lead to greater periphyton biomass below lakes. We tested these hypotheses in study reaches above and below lakes in 3 mountain watersheds. To expand this comparison, we analyzed the relationship between sediment attributes and periphyton biomass in one watershed with and one watershed without a lake. We hypothesized that no clear pattern or change in sediment size or chlorophyll a (chl a) would be observed over a 3-km-long study reach without a lake. In contrast, we expected a clear discontinuity in both sediment size and chl a in a 7-km-long study reach interrupted by a lake. Average median sediment size (D50) was significantly larger (p < 0.01) in lake-outlet than lake-inlet reaches (41 mm vs 10 mm). Bed sediments in lake-outlet reaches were immobile during bankfull flows, whereas sediments at lake-inlet reaches were mobile during bankfull flows. Chlorophyll a was ???10x greater in lake-outlet reaches than in lake-inlet reaches, although this difference was not statistically significant (p = 0.17). The longitudinal analysis clearly showed geomorphic transitions in sediment size and mobility downstream of mountain lakes, and these geomorphic transitions might be associated with changes in periphyton biomass. Geomorphic transitions can alter sediment transport and should be considered in concert with other factors that are considered more commonly in benthic ecology, such as light, nutrients, and temperature. ?? 2007 by The North American Benthological Society.

  17. Endopolyploidy as a potential alternative adaptive strategy for Arabidopsis leaf size variation in response to UV-B.

    PubMed

    Gegas, Vasilis C; Wargent, Jason J; Pesquet, Edouard; Granqvist, Emma; Paul, Nigel D; Doonan, John H

    2014-06-01

    The extent of endoreduplication in leaf growth is group- or even species-specific, and its adaptive role is still unclear. A survey of Arabidopsis accessions for variation at the level of endopolyploidy, cell number, and cell size in leaves revealed extensive genetic variation in endopolyploidy level. High endopolyploidy is associated with increased leaf size, both in natural and in genetically unstructured (mapping) populations. The underlying genes were identified as quantitative trait loci that control endopolyploidy in nature by modulating the progression of successive endocycles during organ development. This complex genetic architecture indicates an adaptive mechanism that allows differential organ growth over a broad geographic range and under stressful environmental conditions. UV-B radiation was identified as a significant positive climatic predictor for high endopolyploidy. Arabidopsis accessions carrying the increasing alleles for endopolyploidy also have enhanced tolerance to UV-B radiation. UV-absorbing secondary metabolites provide an additional protective strategy in accessions that display low endopolyploidy. Taken together, these results demonstrate that high constitutive endopolyploidy is a significant predictor for organ size in natural populations and is likely to contribute to sustaining plant growth under high incident UV radiation. Endopolyploidy may therefore form part of the range of UV-B tolerance mechanisms that exist in natural populations.

  18. When size matters: differences in demineralized bone matrix particles affect collagen structure, mesenchymal stem cell behavior, and osteogenic potential.

    PubMed

    Dozza, B; Lesci, I G; Duchi, S; Della Bella, E; Martini, L; Salamanna, F; Falconi, M; Cinotti, S; Fini, M; Lucarelli, E; Donati, D

    2017-04-01

    Demineralized bone matrix (DBM) is a natural, collagen-based, osteoinductive biomaterial. Nevertheless, there are conflicting reports on the efficacy of this product. The purpose of this study was to evaluate whether DBM collagen structure is affected by particle size and can influence DBM cytocompatibility and osteoinductivity. Sheep cortical bone was ground and particles were divided in three fractions with different sizes, defined as large (L, 1-2 mm), medium (M, 0.5-1 mm), and small (S, <0.5 mm). After demineralization, the chemical-physical analysis clearly showed a particle size-dependent alteration in collagen structure, with DBM-M being altered but not as much as DBM-S. DBM-M displayed a preferable trend in almost all biological characteristics tested, although all DBM particles revealed an optimal cytocompatibility. Subcutaneous implantation of DBM particles into immunocompromised mice resulted in bone induction only for DBM-M. When sheep MSC were seeded onto particles before implantation, all DBM particles were able to induce new bone formation with the best incidence for DBM-M and DBM-S. In conclusion, the collagen alteration in DBM-M is likely the best condition to promote bone induction in vivo. Furthermore, the choice of 0.5-1 mm particles may enable to obtain more efficient and consistent results among different research groups in bone tissue-engineering applications. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1019-1033, 2017.

  19. Concentrating Solar Deployment System (CSDS) -- A New Model for Estimating U.S. Concentrating Solar Power (CSP) Market Potential: Preprint

    SciTech Connect

    Blair, N.; Mehos, M.; Short, W.; Heimiller, D.

    2006-04-01

    This paper presents the Concentrating Solar Deployment System Model (CSDS). CSDS is a multiregional, multitime-period, Geographic Information System (GIS), and linear programming model of capacity expansion in the electric sector of the United States. CSDS is designed to address the principal market and policy issues related to the penetration of concentrating solar power (CSP) electric-sector technologies. This paper discusses the current structure, capabilities, and assumptions of the model. Additionally, results are presented for the impact of continued research and development (R&D) spending, an extension to the investment tax credit (ITC), and use of a production tax credit (PTC). CSDS is an extension of the Wind Deployment System (WinDS) model created at the National Renewable Energy Laboratory (NREL). While WinDS examines issues related to wind, CSDS is an extension to analyze similar issues for CSP applications. Specifically, a detailed representation of parabolic trough systems with thermal storage has been developed within the existing structure.

  20. Influence of temperature, anions and size distribution on the zeta potential of DMPC, DPPC and DMPE lipid vesicles.

    PubMed

    Morini, M A; Sierra, M B; Pedroni, V I; Alarcon, L M; Appignanesi, G A; Disalvo, E A

    2015-07-01

    The purpose of the work is to compare the influence of the multilamellarity, phase state, lipid head groups and ionic media on the origin of the surface potential of lipid membranes. With this aim, we present a new analysis of the zeta potential of multilamellar and unilamellar vesicles composed by phosphatidylcholines (PC) and phosphatidylethanolamines (PE) dispersed in water and ionic solutions of polarizable anions, at temperatures below and above the phase transition. In general, the adsorption of anions seems to explain the origin of the zeta potential in vesicles only above the transition temperature (Tc). In this case, the sign of the surface potential is ascribed to a partial orientation of head group moiety toward the aqueous phase. This is noticeable in PC head groups but not in PEs, due to the strong lateral interaction between PO and NH group in PE.

  1. Physico-Chemical and Bacterial Evaluation of Packaged Drinking Water Marketed in Delhi - Potential Public Health Implications

    PubMed Central

    Singla, Ashish; Kundu, Hansa; P., Basavaraj; Singh, Shilpi; Singh, Khushboo; Jain, Swati

    2014-01-01

    Introduction: Quality of drinking water is a powerful environmental determinant of health. The main objective of introduction of bottled water in the society was its better safety, taste and convenience over tap water. The present study was conducted to assess physicochemical and bacterial qualities of bottled water and sachet water which were available in various markets of Delhi. Materials and Methods: Sixteen water bottles and four water sachets were selected through stratified random sampling from various public places in Delhi and their analysis was done at National Test House, Ghaziabad. Results were then compared with national (IS10500, IS14543) and international (WHO, FDA, USEPA) standards. Results: Bottled water showed better quality than sachet water. The mean value of copper (0.0746mg/l) in bottles exceeded the standard values of IS10500 and IS14543(0.05), while the mean value of lead (0.008mg/l) exceeded the FDA standard value (0.005). When the results of sachets were compared with those of standards, the mean values of selenium (0.1195mg/l) and lead (0.862mg/l) were found to exceed values of both Indian and International standards. For the biological parameter i.e. coliform count, the mean value for bottles was 0 (nil), whereas the mean value for sachets was 16.75, which showed the unhealthy nature of sachets. Conclusion: The parameters which were tested in the present study showed excess of various chemical and bacterial parameters in drinking water, which could pose serious threats to consumers. Thus, these results suggest a more stringent standardization of bottled water market with special attention to quality, identity and licensing by concerned authorities, to safeguard health of consumers. PMID:24783149

  2. Predicting the size- and shape-dependent cohesive energy and order-disorder transition temperature of Co-Pt nanoparticles by embedded-atom-method potential.

    PubMed

    Liu, Chenze; Qi, Weihong; Ouyang, Bin; Wang, Xing; Huang, Baiyun

    2013-02-01

    The cohesive energy (CE) of CoPt nanoparticles (NPs) with different sizes and shapes have been calculated by embedded-atom-method (EAM) potential. It is shown that CE of NPs with order or disorder structures decreases with the decrease of particle size, while the shape effects become obvious only at small size. The CE difference per atom between order and disorder structures decreases with the decrease of particle size, indicating that the possibility of order-disorder transition in small size becomes larger compared with these in large size. Significantly, the CE difference varies in proportion to order-disorder transition temperature (T(c)), which suggests that one can predict order-disorder transition of NPs by calculation the cohesive energy. The present calculated T(c) of CoPt NPs is consistent with recent experiments, simulation and theoretical predictions, and the method can also be applied to study the order-disorder transition of FePt, FePd, and so on.

  3. Analysis of Large Seeds from Three Different Medicago truncatula Ecotypes Reveals a Potential Role of Hormonal Balance in Final Size Determination of Legume Grains

    PubMed Central

    Bandyopadhyay, Kaustav; Uluçay, Orhan; Şakiroğlu, Muhammet; Udvardi, Michael K.; Verdier, Jerome

    2016-01-01

    Legume seeds are important as protein and oil source for human diet. Understanding how their final seed size is determined is crucial to improve crop yield. In this study, we analyzed seed development of three accessions of the model legume, Medicago truncatula, displaying contrasted seed size. By comparing two large seed accessions to the reference accession A17, we described mechanisms associated with large seed size determination and potential factors modulating the final seed size. We observed that early events during embryogenesis had a major impact on final seed size and a delayed heart stage embryo development resulted to large seeds. We also observed that the difference in seed growth rate was mainly due to a difference in embryo cell number, implicating a role of cell division rate. Large seed accessions could be explained by an extended period of cell division due to a longer embryogenesis phase. According to our observations and recent reports, we observed that auxin (IAA) and abscisic acid (ABA) ratio could be a key determinant of cell division regulation at the end of embryogenesis. Overall, our study highlights that timing of events occurring during early seed development play decisive role for final seed size determination. PMID:27618017

  4. Coal briquetting in Pakistan: A market and business assessment

    SciTech Connect

    Stevenson, G.G.; Willson, T.D.

    1988-04-01

    Our objectives are to evaluate the potential financial success of an unsubsidized, private sector coal briquetting venture in Pakistan, based on financial competitiveness in market niches, market size, and consumer acceptance; to examine private sector interest and potential business arrangements; to examine potential effects of government policies on such an undertaking; and to make recommendations to the private sector, USAID, and the Government of Pakistan on further work. Our results show that coal briquettes potentially can compete against firewood in some markets, particularly in certain urban areas of Punjab and most urban markets of the NWFP. Salt Range or Makerwal coal would be used for these briquettes. Coal briquettes will also compete against charcoal and kerosene in many areas of Pakistan. The most promising briquette is a coal/biomass mixture not requiring carbonization. A limited opportunity may also exist for a carbonized briquette using Makerwal coal. Smoky briquettes for space heating also are competitive in certain areas, but market size is limiting. The total penetrable residential market for coal briquettes in the Punjab and NWFP of 440,000 to 545,000 tonnes of briquettes per year replacing firewood is sufficiently large to support one or more plants of 50,000 tonnes per year. Charcoal, kerosene, and commercial uses of briquettes could add to this market. 9 refs., 20 figs., 39 tabs.

  5. Massively parallel rRNA gene sequencing exacerbates the potential for biased community diversity comparisons due to variable library sizes

    SciTech Connect

    Gihring, Thomas; Green, Stefan; Schadt, Christopher Warren

    2011-01-01

    Technologies for massively parallel sequencing are revolutionizing microbial ecology and are vastly increasing the scale of ribosomal RNA (rRNA) gene studies. Although pyrosequencing has increased the breadth and depth of possible rRNA gene sampling, one drawback is that the number of reads obtained per sample is difficult to control. Pyrosequencing libraries typically vary widely in the number of sequences per sample, even within individual studies, and there is a need to revisit the behaviour of richness estimators and diversity indices with variable gene sequence library sizes. Multiple reports and review papers have demonstrated the bias in non-parametric richness estimators (e.g. Chao1 and ACE) and diversity indices when using clone libraries. However, we found that biased community comparisons are accumulating in the literature. Here we demonstrate the effects of sample size on Chao1, ACE, CatchAll, Shannon, Chao-Shen and Simpson's estimations specifically using pyrosequencing libraries. The need to equalize the number of reads being compared across libraries is reiterated, and investigators are directed towards available tools for making unbiased diversity comparisons.

  6. A comparison of hydraulic architecture in three similarly sized woody species differing in their maximum potential height.

    PubMed

    McCulloh, Katherine A; Johnson, Daniel M; Petitmermet, Joshua; McNellis, Brandon; Meinzer, Frederick C; Lachenbruch, Barbara

    2015-07-01

    The physiological mechanisms underlying the short maximum height of shrubs are not understood. One possible explanation is that differences in the hydraulic architecture of shrubs compared with co-occurring taller trees prevent the shrubs from growing taller. To explore this hypothesis, we examined various hydraulic parameters, including vessel lumen diameter, hydraulic conductivity and vulnerability to drought-induced embolism, of three co-occurring species that differed in their maximum potential height. We examined one species of shrub, one short-statured tree and one taller tree. We worked with individuals that were approximately the same age and height, which was near the maximum for the shrub species. A number of variables correlated with the maximum potential height of the species. For example, vessel diameter and vulnerability to embolism both increased while wood density declined with maximum potential height. The difference between the pressure causing 50% reduction in hydraulic conductance in the leaves and the midday leaf water potential (the leaf's hydraulic safety margin) was much larger in the shrub than the other two species. In general, trends were consistent with understory shrubs having a more conservative life history strategy than co-occurring taller species.

  7. Relationship between pore size and reversible and irreversible immobilization of ionic liquid electrolytes in porous carbon under applied electric potential

    DOE PAGES

    Mahurin, Shannon M.; Mamontov, Eugene; Thompson, Matthew W.; ...

    2016-10-04

    Transport of electrolytes in nanoporous carbon-based electrodes largely defines the function and performance of energy storage devices. Here, using molecular dynamics simulation and quasielastic neutron scattering, we investigate the microscopic dynamics of a prototypical ionic liquid electrolyte, [emim][Tf2N], under applied electric potential in carbon materials with 6.7 nm and 1.5 nm pores. The simulations demonstrate the formation of dense layers of counter-ions near the charged surfaces, which is reversible when the polarity is reversed. In the experiment, the ions immobilized near the surface manifest themselves in the elastic scattering signal. The experimentally observed ion immobilization near the wall is fullymore » reversible as a function of the applied electric potential in the 6.7 nm, but not in the 1.5 nm nanopores. In the latter case, remarkably, the first application of the electric potential leads to apparently irreversible immobilization of cations or anions, depending on the polarity, near the carbon pore walls. This unexpectedly demonstrates that in carbon electrode materials with the small pores, which are optimal for energy storage applications, the polarity of the electrical potential applied for the first time after the introduction of an ionic liquid electrolyte may define the decoration of the small pore walls with ions for prolonged periods of time and possibly for the lifetime of the electrode.« less

  8. Relationship between pore size and reversible and irreversible immobilization of ionic liquid electrolytes in porous carbon under applied electric potential

    SciTech Connect

    Mahurin, Shannon M.; Mamontov, Eugene; Thompson, Matthew W.; Zhang, Pengfei; Turner, C. Heath; Cummings, Peter T.; Dai, Sheng

    2016-10-04

    Transport of electrolytes in nanoporous carbon-based electrodes largely defines the function and performance of energy storage devices. Here, using molecular dynamics simulation and quasielastic neutron scattering, we investigate the microscopic dynamics of a prototypical ionic liquid electrolyte, [emim][Tf2N], under applied electric potential in carbon materials with 6.7 nm and 1.5 nm pores. The simulations demonstrate the formation of dense layers of counter-ions near the charged surfaces, which is reversible when the polarity is reversed. In the experiment, the ions immobilized near the surface manifest themselves in the elastic scattering signal. The experimentally observed ion immobilization near the wall is fully reversible as a function of the applied electric potential in the 6.7 nm, but not in the 1.5 nm nanopores. In the latter case, remarkably, the first application of the electric potential leads to apparently irreversible immobilization of cations or anions, depending on the polarity, near the carbon pore walls. This unexpectedly demonstrates that in carbon electrode materials with the small pores, which are optimal for energy storage applications, the polarity of the electrical potential applied for the first time after the introduction of an ionic liquid electrolyte may define the decoration of the small pore walls with ions for prolonged periods of time and possibly for the lifetime of the electrode.

  9. Relationship between pore size and reversible and irreversible immobilization of ionic liquid electrolytes in porous carbon under applied electric potential

    NASA Astrophysics Data System (ADS)

    Mahurin, Shannon M.; Mamontov, Eugene; Thompson, Matthew W.; Zhang, Pengfei; Turner, C. Heath; Cummings, Peter T.; Dai, Sheng

    2016-10-01

    Transport of electrolytes in nanoporous carbon-based electrodes largely defines the function and performance of energy storage devices. Using molecular dynamics simulation and quasielastic neutron scattering, we investigate the microscopic dynamics of a prototypical ionic liquid electrolyte, [emim][Tf2N], under applied electric potential in carbon materials with 6.7 nm and 1.5 nm pores. The simulations demonstrate the formation of dense layers of counter-ions near the charged surfaces, which is reversible when the polarity is reversed. In the experiment, the ions immobilized near the surface manifest themselves in the elastic scattering signal. The experimentally observed ion immobilization near the wall is fully reversible as a function of the applied electric potential in the 6.7 nm, but not in the 1.5 nm nanopores. In the latter case, remarkably, the first application of the electric potential leads to apparently irreversible immobilization of cations or anions, depending on the polarity, near the carbon pore walls. This unexpectedly demonstrates that in carbon electrode materials with the small pores, which are optimal for energy storage applications, the polarity of the electrical potential applied for the first time after the introduction of an ionic liquid electrolyte may define the decoration of the small pore walls with ions for prolonged periods of time and possibly for the lifetime of the electrode.

  10. Livestock Marketing.

    ERIC Educational Resources Information Center

    Futrell, Gene; And Others

    This marketing unit focuses on the seasonal and cyclical patterns of livestock markets. Cash marketing, forward contracting, hedging in the futures markets, and the options markets are examined. Examples illustrate how each marketing tool may be useful in gaining a profit on livestock and cutting risk exposure. The unit is organized in the…

  11. Potential conflict between TRIPS and GATT concerning parallel importation of drugs and possible solution to prevent undesirable market segmentation.

    PubMed

    Lo, Chang-Fa

    2011-01-01

    From international perspective, parallel importation, especially with respect to drugs, has to do with the exhaustion principle in Article 6 of the TRIPS Agreement and the general exception in Article XX of the GATT 1994. Issues concerning the TRIPS Agreement have been constant topics of discussion. However, parallel importation in relation to the general rules of the GATT 1994 as well as to its exceptions provided in Article XX was not seriously discussed. In the view of the paper, there is a conflict between the provisions in these two agreements. The paper explains such conflict and tries to propose a method of interpretation to resolve the conflict between GATT Article XX and TRIPS Article 6 concerning parallel importation for the purpose of reducing the possible undesirable market segmentation in pharmaceutical sector. The method suggested in the paper is a proper application of good faith principle in the Vienna Convention to interpret GATT Article XX, so that there could be some flexibility for those prohibitions of parallel importation which have positive effect on international trade.

  12. Behavioral indicators of household decision-making and demand for sanitation and potential gains from social marketing in Ghana.

    PubMed

    Jenkins, Marion W; Scott, Beth

    2007-06-01

    Household demand for improved sanitation in developing countries is an important social and behavioral process with implications for public health, sanitation policy and planning, and sanitation design and technology development. This paper develops a behavioral approach to assess household demand for improved sanitation in Ghana. Adoption decision stages of preference, intention, and choice to install a toilet in Ghana are defined, measured in a survey, and used to estimate sanitation demand, identify factors affecting demand at each stage, and classify households by adoption stage to identify targeted demand-stimulation strategies. Results from a representative national sample of 536 households indicate that of 74% of households without any home sanitation, 31% have some likelihood of installing a toilet within the next year, but only 6% are very likely to do so; 62% had not considered the idea. Motivating and constraining factors are compared at each adoption stage and strategies likely to increase toilet installation in Ghana discussed. The approach is useful for assessing behavioral indicators of sanitation demand in developing countries and suggesting where marketing approaches can and cannot work to accelerate adoption of household sanitation improvements.

  13. Irrigation market for solar thermal parabolic dish systems

    NASA Technical Reports Server (NTRS)

    Habib-Agahi, H.; Jones, S. C.

    1981-01-01

    The potential size of the onfarm-pumped irrigation market for solar thermal parabolic dish systems in seven high-insolation states is estimated. The study is restricted to the displacement of three specific fuels: gasoline, diesel and natural gas. The model was developed to estimate the optimal number of parabolic dish modules per farm based on the minimum cost mix of conventional and solar thermal energy required to meet irrigation needs. The study concludes that the potential market size for onfarm-pumped irrigation applications ranges from 101,000 modules when a 14 percent real discount rate is assumed to 220,000 modules when the real discount rate drops to 8 percent. Arizona, Kansas, Nebraska, New Mexico and Texas account for 98 percent of the total demand for this application, with the natural gas replacement market accounting for the largest segment (71 percent) of the total market.

  14. Irrigation market for solar thermal parabolic dish systems

    NASA Astrophysics Data System (ADS)

    Habib-Agahi, H.; Jones, S. C.

    1981-09-01

    The potential size of the onfarm-pumped irrigation market for solar thermal parabolic dish systems in seven high-insolation states is estimated. The study is restricted to the displacement of three specific fuels: gasoline, diesel and natural gas. The model was developed to estimate the optimal number of parabolic dish modules per farm based on the minimum cost mix of conventional and solar thermal energy required to meet irrigation needs. The study concludes that the potential market size for onfarm-pumped irrigation applications ranges from 101,000 modules when a 14 percent real discount rate is assumed to 220,000 modules when the real discount rate drops to 8 percent. Arizona, Kansas, Nebraska, New Mexico and Texas account for 98 percent of the total demand for this application, with the natural gas replacement market accounting for the largest segment (71 percent) of the total market.

  15. Breaking through market barriers with an improved sizing method: Case study of a stand-alone PV system in the northern Sudan

    SciTech Connect

    Lewis, G. )

    1990-12-01

    According to the sizing methodology used here, a stand-alone photovoltaic irrigation water-pumping system for installation in northern Sudan would cost less than anticipated by other sizing methods. This method makes use of the concept of system reliability or availability without the attendant computational complexity or unwieldiness associated with many other sizing methodologies presented in the literature. Thus, two barriers to the use of photovoltaic systems for electricity generation are addressed by an improved method of estimation. One is the commonly cited claim that PV systems are too costly. The other is that the computer-aided design methods for predicting performance are too complex or difficult to use. This makes one wonder if other objections to the use of renewable-energy technologies could be overcome through improving methods of specifying systems. 19 refs., 4 figs., 1 tab.

  16. Postoperative Stereotactic Radiosurgery Without Whole-Brain Radiation Therapy for Brain Metastases: Potential Role of Preoperative Tumor Size

    SciTech Connect

    Hartford, Alan C.; Paravati, Anthony J.; Spire, William J.; Li, Zhongze; Jarvis, Lesley A.; Fadul, Camilo E.; Erkmen, Kadir; Friedman, Jonathan; Gladstone, David J.; Hug, Eugen B.; Roberts, David W.; Simmons, Nathan E.

    2013-03-01

    Purpose: Radiation therapy following resection of a brain metastasis increases the probability of disease control at the surgical site. We analyzed our experience with postoperative stereotactic radiosurgery (SRS) as an alternative to whole-brain radiotherapy (WBRT), with an emphasis on identifying factors that might predict intracranial disease control and overall survival (OS). Methods and Materials: We retrospectively reviewed all patients through December 2008, who, after surgical resection, underwent SRS to the tumor bed, deferring WBRT. Multiple factors were analyzed for time to intracranial recurrence (ICR), whether local recurrence (LR) at the surgical bed or “distant” recurrence (DR) in the brain, for time to WBRT, and for OS. Results: A total of 49 lesions in 47 patients were treated with postoperative SRS. With median follow-up of 9.3 months (range, 1.1-61.4 months), local control rates at the resection cavity were 85.5% at 1 year and 66.9% at 2 years. OS rates at 1 and 2 years were 52.5% and 31.7%, respectively. On univariate analysis (preoperative) tumors larger than 3.0 cm exhibited a significantly shorter time to LR. At a cutoff of 2.0 cm, larger tumors resulted in significantly shorter times not only for LR but also for DR, ICR, and salvage WBRT. While multivariate Cox regressions showed preoperative size to be significant for times to DR, ICR, and WBRT, in similar multivariate analysis for OS, only the graded prognostic assessment proved to be significant. However, the number of intracranial metastases at presentation was not significantly associated with OS nor with other outcome variables. Conclusions: Larger tumor size was associated with shorter time to recurrence and with shorter time to salvage WBRT; however, larger tumors were not associated with decrements in OS, suggesting successful salvage. SRS to the tumor bed without WBRT is an effective treatment for resected brain metastases, achieving local control particularly for tumors up to

  17. Using a Reduced Spot Size for Intensity-Modulated Proton Therapy Potentially Improves Salivary Gland-Sparing in Oropharyngeal Cancer

    SciTech Connect

    Water, Tara A. van de; Lomax, Antony J.; Bijl, Hendrik P.; Schilstra, Cornelis; Hug, Eugen B.; Langendijk, Johannes A.

    2012-02-01

    Purpose: To investigate whether intensity-modulated proton therapy with a reduced spot size (rsIMPT) could further reduce the parotid and submandibular gland dose compared with previously calculated IMPT plans with a larger spot size. In addition, it was investigated whether the obtained dose reductions would theoretically translate into a reduction of normal tissue complication probabilities (NTCPs). Methods: Ten patients with N0 oropharyngeal cancer were included in a comparative treatment planning study. Both IMPT plans delivered simultaneously 70 Gy to the boost planning target volume (PTV) and 54 Gy to the elective nodal PTV. IMPT and rsIMPT used identical three-field beam arrangements. In the IMPT plans, the parotid and submandibular salivary glands were spared as much as possible. rsIMPT plans used identical dose-volume objectives for the parotid glands as those used by the IMPT plans, whereas the objectives for the submandibular glands were tightened further. NTCPs were calculated for salivary dysfunction and xerostomia. Results: Target coverage was similar for both IMPT techniques, whereas rsIMPT clearly improved target conformity. The mean doses in the parotid glands and submandibular glands were significantly lower for three-field rsIMPT (14.7 Gy and 46.9 Gy, respectively) than for three-field IMPT (16.8 Gy and 54.6 Gy, respectively). Hence, rsIMPT significantly reduced the NTCP of patient-rated xerostomia and parotid and contralateral submandibular salivary flow dysfunction (27%, 17%, and 43% respectively) compared with IMPT (39%, 20%, and 79%, respectively). In addition, mean dose values in the sublingual glands, the soft palate and oral cavity were also decreased. Obtained dose and NTCP reductions varied per patient. Conclusions: rsIMPT improved sparing of the salivary glands and reduced NTCP for xerostomia and parotid and submandibular salivary dysfunction, while maintaining similar target coverage results. It is expected that rsIMPT improves quality

  18. Two eggs, two different constraints: a potential explanation for the puzzling intraclutch egg size dimorphism in Eudyptes penguins

    PubMed Central

    Poisbleau, Maud; Dehnhard, Nina; Demongin, Laurent; Quillfeldt, Petra; Eens, Marcel

    2015-01-01

    Phenotypic plasticity and phenotypic stability are major components of the adaptive evolution of organisms to environmental variation. The invariant two-egg clutch size of Eudyptes penguins has recently been proposed to be a unique example of a maladaptive phenotypic stability, while their egg mass is a plastic trait. We tested whether this phenotypic plasticity during reproduction might result from constraints imposed by migration (migratory carry-over effect) and breeding (due to the depletion of female body reserves). For the first time, we examined whether these constraints differ between eggs within clutches and between egg components (yolk and albumen). The interval between colony return and clutch initiation positively influenced the yolk mass, the albumen mass, and the subsequent total egg mass of first-laid eggs. This time interval had only a slight negative influence on the yolk mass of second-laid eggs and no influence on their albumen and subsequent total masses. For both eggs, female body mass at laying positively influenced albumen and total egg masses. Female investment into the entire clutch was not related to the time in the colony before laying but increased with female body mass. These novel results suggest that the unique intraclutch egg size dimorphism exhibited in Eudyptes penguins, with first-laid eggs being consistently smaller than second-laid eggs, might be due to a combination of constraints: a migratory carry-over effect on the first-laid egg and a body reserve depletion effect on the second-laid egg. Both these constraints might explain why the timing of reproduction, especially egg formation, is narrow in migratory capital breeders. PMID:26306169

  19. Pin potential effect on vortex pinning in YBa2Cu3O7-δ films containing nanorods: Pin size effect and mixed pinning

    NASA Astrophysics Data System (ADS)

    Horide, Tomoya; Matsukida, Naoki; Ishimaru, Manabu; Kita, Ryusuke; Awaji, Satoshi; Matsumoto, Kaname

    2017-01-01

    The pin size effect and mixed pinning of nanorods and matrix defects are discussed for YBa2Cu3O7-δ films containing nanorods. BaSnO3 nanorods with a diameter of 11 nm and BaHfO3 nanorods with a diameter of 7 nm were prepared, and critical current density (Jc) and resistivity were measured in the films. When the coherence length was larger than the nanorod size at high temperatures near the critical temperature, the trapping angle and activation energy of the vortex flow depended on the nanorod diameter. At a moderate temperature of 65-77 K, the pin size effect on Jc disappeared since the coherence length became smaller than the nanorod size. At a low temperature of 20 K, the contribution from matrix pinning became comparable to that of nanorods in a high magnetic field due to the small coherence length. Thus, the temperature-dependent coherence length caused the pin potential situation to vary significantly, namely, the pin size effect and mixed pinning, which strongly affected vortex pinning in YBa2Cu3O7-δ containing nanorods.

  20. Room temperature ionic liquids: A simple model. Effect of chain length and size of intermolecular potential on critical temperature

    NASA Astrophysics Data System (ADS)

    Chapela, Gustavo A.; Guzmán, Orlando; Díaz-Herrera, Enrique; del Río, Fernando

    2015-04-01

    A model of a room temperature ionic liquid can be represented as an ion attached to an aliphatic chain mixed with a counter ion. The simple model used in this work is based on a short rigid tangent square well chain with an ion, represented by a hard sphere interacting with a Yukawa potential at the head of the chain, mixed with a counter ion represented as well by a hard sphere interacting with a Yukawa potential of the opposite sign. The length of the chain and the depth of the intermolecular forces are investigated in order to understand which of these factors are responsible for the lowering of the critical temperature. It is the large difference between the ionic and the dispersion potentials which explains this lowering of the critical temperature. Calculation of liquid-vapor equilibrium orthobaric curves is used to estimate the critical points of the model. Vapor pressures are used to obtain an estimate of the triple point of the different models in order to calculate the span of temperatures where they remain a liquid. Surface tensions and interfacial thicknesses are also reported.

  1. Room temperature ionic liquids: A simple model. Effect of chain length and size of intermolecular potential on critical temperature.

    PubMed

    Chapela, Gustavo A; Guzmán, Orlando; Díaz-Herrera, Enrique; del Río, Fernando

    2015-04-21

    A model of a room temperature ionic liquid can be represented as an ion attached to an aliphatic chain mixed with a counter ion. The simple model used in this work is based on a short rigid tangent square well chain with an ion, represented by a hard sphere interacting with a Yukawa potential at the head of the chain, mixed with a counter ion represented as well by a hard sphere interacting with a Yukawa potential of the opposite sign. The length of the chain and the depth of the intermolecular forces are investigated in order to understand which of these factors are responsible for the lowering of the critical temperature. It is the large difference between the ionic and the dispersion potentials which explains this lowering of the critical temperature. Calculation of liquid-vapor equilibrium orthobaric curves is used to estimate the critical points of the model. Vapor pressures are used to obtain an estimate of the triple point of the different models in order to calculate the span of temperatures where they remain a liquid. Surface tensions and interfacial thicknesses are also reported.

  2. Marketing Continuing Education for Nurses.

    ERIC Educational Resources Information Center

    Southern Regional Education Board, Atlanta, GA.

    This guide presents an overview of marketing and its potential value in continuing education programs for nurses. The first portion of the guide briefly discusses the concept of marketing. It contains definitions of key marketing concepts (product, place, price, and promotion), discussion of the basic tenets of marketing (consumer needs…

  3. hERG blocking potential of acids and zwitterions characterized by three thresholds for acidity, size and reactivity.

    PubMed

    Nikolov, Nikolai G; Dybdahl, Marianne; Jónsdóttir, Svava Ó; Wedebye, Eva B

    2014-11-01

    Ionization is a key factor in hERG K(+) channel blocking, and acids and zwitterions are known to be less probable hERG blockers than bases and neutral compounds. However, a considerable number of acidic compounds block hERG, and the physico-chemical attributes which discriminate acidic blockers from acidic non-blockers have not been fully elucidated. We propose a rule for prediction of hERG blocking by acids and zwitterionic ampholytes based on thresholds for only three descriptors related to acidity, size and reactivity. The training set of 153 acids and zwitterionic ampholytes was predicted with a concordance of 91% by a decision tree based on the rule. Two external validations were performed with sets of 35 and 48 observations, respectively, both showing concordances of 91%. In addition, a global QSAR model of hERG blocking was constructed based on a large diverse training set of 1374 chemicals covering all ionization classes, externally validated showing high predictivity and compared to the decision tree. The decision tree was found to be superior for the acids and zwitterionic ampholytes classes.

  4. Organelles and chromatin fragmentation of human umbilical vein endothelial cell influence by the effects of zeta potential and size of silver nanoparticles in different manners.

    PubMed

    Tavakol, Shima; Hoveizi, Elham; Kharrazi, Sharmin; Tavakol, Behnaz; Karimi, Shabnam; Rezayat Sorkhabadi, Seyed Mahdi

    2017-06-01

    Recently, it has been disclosed that silver nanoparticles (AgNPs) have the potential to inhibit infection and cancerous cells and eventually penetrate through injected site into the capillary due to their small size. This study focuses on the effect of size and zeta potential of bare and citrate-coated AgNPs on human umbilical vein endothelial cells (HUVECs) as main capillary cells. AgNPs with high and low concentrations and no citrate coating were synthesized by using simple wet chemical method and named as AgNP/HC, AgNP/LC, and AgNP, respectively. Citrate coated particles showed larger zeta potential of -22 mV and AgNp/HC showed the smallest size of 13.2 nm. UV-Visible spectroscopy and dynamic light scattering (DLS) were performed to evaluate particle size and hydrodynamic diameter of NPs in water and cell culture media. Results indicated that higher concentrations of citrate decreased hydrodynamic diameter and NP agglomeration. reactive oxygen species (ROS) production of all AgNPs was similar at 28 ppm although it was significantly higher than control group. Their effects on cell membrane and chromosomal structure were studied using LDH measurement and 4',6-diamidino-2-phenylindole (DAPI) staining, as well. Results demonstrated that AgNP/LC was less toxic to cells owing to higher value of IC50, minimum inhibitory concentration (MIC), and less release of LDH. Cancerous (Human Caucasian neuroblastoma) and immortal cells (Mouse embryonic fibroblast cell line) were about twice more sensitive than HUVECs to toxic effects of AgNPs. DAPI staining results showed that AgNP and AgNP/HC induced highest and lowest breaking of chromosome. Overall results suggest that viability of HUVECs will be higher than 90% when viability of cancerous cells is 50% in AgNPs chemotherapy.

  5. Evaluation of rhBMP-2 and natural latex as potential osteogenic proteins in critical size defects by histomorphometric methods.

    PubMed

    Issa, João Paulo Mardegan; Defino, Helton Luiz Aparecido; Netto, Joaquim Coutinho; Volpon, José Batista; Regalo, Simone Cecílio Hallak; Iyomasa, Mamie Mizusaki; Siéssere, Selma; Tiossi, Rodrigo

    2010-05-01

    This in vivo study evaluated the osteogenic potential of two proteins, recombinant human bone morphogenetic protein-2 (rhBMP-2) and a protein extracted from natural latex (Hevea brasiliensis, P-1), and compared their effects on bone defects when combined with a carrier or a collagen gelatin. Eighty-four (84) Wistar rats were divided into two groups, with and without the use of collagen gelatin, and each of these were divided into six treatment groups of seven animals each. The treatment groups were: (1) 5 microg of pure rhBMP-2; (2) 5 microg of rhBMP-2/monoolein gel; (3) pure monoolein gel; (4) 5 microg of pure P-1; (5) 5 microg of P-1/monoolein gel; (6) critical bone defect control. The animals were anesthetized and a 6 mm diameter critical bone defect was made in the left posterior region of the parietal bone. Animals were submitted to intracardiac perfusion after 4 weeks and the calvaria tissue was removed for histomorphometric analysis. In this experimental study, it was concluded that rhBMP-2 allowed greater new bone formation than P-1 protein and this process was more effective when the bone defect was covered with collagen gelatin (P < 0.05).

  6. TiO 2(B) as a promising high potential negative electrode for large-size lithium-ion batteries

    NASA Astrophysics Data System (ADS)

    Inaba, Minoru; Oba, Yasuyuki; Niina, Fumiharu; Murota, Yosuke; Ogino, Yasuyuki; Tasaka, Akimasa; Hirota, Ken

    Needle-like TiO 2(B) powder was obtained from K 2Ti 4O 9 precursor by ion exchange to protons, followed by dehydration. The charge and discharge characteristics of the TiO 2(B) powder were investigated as a high potential negative electrode in lithium-ion batteries. It had a high discharge capacity of 200-250 mAh g -1 at around 1.6 V vs. Li/Li +, which was comparable with that of TiO 2(B) nanowires and nanotubes prepared via a hydrothermal reaction in alkaline solution. It showed very good cycleability, and gave a discharge capacity of 170 mAh g -1 even in the 650th cycle. It also had a high rate capability, and gave a discharge capacity of 106 mAh g -1 even at 10 °C. In most of ethylene carbonate-based solutions, the TiO 2(B) powder exhibited good charge and discharge characteristics. However, it showed a poor compatibility with LiBF 4, propylene carbonate, and γ-butyrolactone. The TiO 2(B) powder showed good cycle performance in the presence of a non-flammable additive, trimethyl phosphate, up to 20 vol.%, and a high tolerance to water up to 1000 ppm. It was also found that inexpensive Al foil can be used as a current collector of the TiO 2(B) powder instead of Cu foil without sacrificing the performance.

  7. Investigation of truck size and weight limits: technical supplement volume 7. carrier, market and regional cost and energy tradeoffs, part i. Final report oct 78-oct 81

    SciTech Connect

    Maio, D.J.

    1982-10-01

    This volume expands upon the summary results in the Secretary's Report to Congress and provides a more comprehensive treatment of the productivity and fuel tradeoffs among the categories of truck size, weight and configuration limits. Disaggregations of impacts among freight service user groups are reported to provide information to the interest groups most affected by alternative limit changes. It also presents an analysis of the sensitivity of the reported transport cost and fuel impacts of alternative limits to the possible inaccuracies in the analytical methods and data available to the study.

  8. Market analysis of shale oil co-products. Summary report

    SciTech Connect

    Not Available

    1980-12-01

    This study examines the potential for separating, upgrading and marketing sodium mineral co-products together with shale oil production. The co-products investigated are soda ash and alumina which are derived from the minerals nahcolite and dawsonite. Five cases were selected to reflect the variance in mineral and shale oil content in the identified resource. In the five cases examined, oil content of the shale was varied from 20 to 30 gallons per ton. Two sizes of facilities were analyzed for each resource case to determine economies of scale between a 15,000 barrel per day demonstration unit and a 50,000 barrel per day full sized plant. Three separate pieces of analysis were conducted in this study: analysis of manufacturing costs for shale oil and co-products; projection of potential world markets for alumina, soda ash, and nahcolite; and determination of economic viability and market potential for shale co-products.

  9. North American Natural Gas Markets

    SciTech Connect

    Not Available

    1988-12-01

    This report sunnnarizes the research by an Energy Modeling Forum working group on the evolution of the North American natural gas markets between now and 2010. The group's findings are based partly on the results of a set of economic models of the natural gas industry that were run for four scenarios representing significantly different conditions: two oil price scenarios (upper and lower), a smaller total US resource base (low US resource case), and increased potential gas demand for electric generation (high US demand case). Several issues, such as the direction of regulatory policy and the size of the gas resource base, were analyzed separately without the use of models.

  10. Solar Installation Labor Market Analysis

    SciTech Connect

    Friedman, B.; Jordan, P.; Carrese, J.

    2011-12-01

    The potential economic benefits of the growing renewable energy sector have led to increased federal, state, and local investments in solar industries, including federal grants for expanded workforce training for U.S. solar installers. However, there remain gaps in the data required to understand the size and composition of the workforce needed to meet the demand for solar power. Through primary research on the U.S. solar installation employer base, this report seeks to address that gap, improving policymakers and other solar stakeholders understanding of both the evolving needs of these employers and the economic opportunity associated with solar market development. Included are labor market data covering current U.S. employment, expected industry growth, and employer skill preferences for solar installation-related occupations. This study offers an in-depth look at the solar installation sectors. A study published by the Solar Foundation in October 2011 provides a census of labor data across the entire solar value chain.

  11. Evolution of microbial markets.

    PubMed

    Werner, Gijsbert D A; Strassmann, Joan E; Ivens, Aniek B F; Engelmoer, Daniel J P; Verbruggen, Erik; Queller, David C; Noë, Ronald; Johnson, Nancy Collins; Hammerstein, Peter; Kiers, E Toby

    2014-01-28

    Biological market theory has been used successfully to explain cooperative behavior in many animal species. Microbes also engage in cooperative behaviors, both with hosts and other microbes, that can be described in economic terms. However, a market approach is not traditionally used to analyze these interactions. Here, we extend the biological market framework to ask whether this theory is of use to evolutionary biologists studying microbes. We consider six economic strategies used by microbes to optimize their success in markets. We argue that an economic market framework is a useful tool to generate specific and interesting predictions about microbial interactions, including the evolution of partner discrimination, hoarding strategies, specialized versus diversified mutualistic services, and the role of spatial structures, such as flocks and consortia. There is untapped potential for studying the evolutionary dynamics of microbial systems. Market theory can help structure this potential by characterizing strategic investment of microbes across a diversity of conditions.

  12. Evolution of microbial markets

    PubMed Central

    Werner, Gijsbert D. A.; Strassmann, Joan E.; Ivens, Aniek B. F.; Engelmoer, Daniel J. P.; Verbruggen, Erik; Queller, David C.; Noë, Ronald; Johnson, Nancy Collins; Hammerstein, Peter; Kiers, E. Toby

    2014-01-01

    Biological market theory has been used successfully to explain cooperative behavior in many animal species. Microbes also engage in cooperative behaviors, both with hosts and other microbes, that can be described in economic terms. However, a market approach is not traditionally used to analyze these interactions. Here, we extend the biological market framework to ask whether this theory is of use to evolutionary biologists studying microbes. We consider six economic strategies used by microbes to optimize their success in markets. We argue that an economic market framework is a useful tool to generate specific and interesting predictions about microbial interactions, including the evolution of partner discrimination, hoarding strategies, specialized versus diversified mutualistic services, and the role of spatial structures, such as flocks and consortia. There is untapped potential for studying the evolutionary dynamics of microbial systems. Market theory can help structure this potential by characterizing strategic investment of microbes across a diversity of conditions. PMID:24474743

  13. Assessment of underground coal gasification in bituminous coals: potential UCG products and markets. Final report, Phase I

    SciTech Connect

    1982-01-31

    The following conclusions were drawn from the study: (1) The US will continue to require new sources of energy fuels and substitutes for petrochemical feedstocks into the foreseeable future. Most of this requirement will be met using coal. However, the cost of mining, transporting, cleaning, and preparing coal, disposing of ash or slag and scrubbing stack gases continues to rise; particularly, in the Eastern US where the need is greatest. UCG avoids these pitfalls and, as such, should be considered a viable alternative to the mining of deeper coals. (2) Of the two possible product gases LBG and MBG, MBG is the most versatile. (3) The most logical use for UCG product in the Eastern US is to generate power on-site using a combined-cycle or co-generation system. Either low or medium Btu gas (LBG or MBG) can be used. (4) UCG should be an option whenever surface gasification is considered; particularly, in areas where deeper, higher sulfur coal is located. (5) There are environmental and social benefits to use of UCG over surface gasification in the Eastern US. (6) A site could be chosen almost anywhere in the Illinois and Ohio area where amenable UCG coal has been determined due to the existence of existing transportation or transmission systems. (7) The technology needs to be demonstrated and the potential economic viability determined at a site in the East-North-Central US which has commercial quantities of amenable bituminous coal before utilities will show significant interest.

  14. Communication impacting financial markets

    NASA Astrophysics Data System (ADS)

    Vitting Andersen, Jørgen; Vrontos, Ioannis; Dellaportas, Petros; Galam, Serge

    2014-10-01

    Since the attribution of the Nobel prize in 2002 to Kahneman for prospect theory, behavioral finance has become an increasingly important subfield of finance. However the main parts of behavioral finance, prospect theory included, understand financial markets through individual investment behavior. Behavioral finance thereby ignores any interaction between participants. We introduce a socio-financial model (Vitting Andersen J. and Nowak A., An Introduction to Socio-Finance (Springer, Berlin) 2013) that studies the impact of communication on the pricing in financial markets. Considering the simplest possible case where each market participant has either a positive (bullish) or negative (bearish) sentiment with respect to the market, we model the evolution of the sentiment in the population due to communication in subgroups of different sizes. Nonlinear feedback effects between the market performance and changes in sentiments are taken into account by assuming that the market performance is dependent on changes in sentiments (e.g., a large sudden positive change in bullishness would lead to more buying). The market performance in turn has an impact on the sentiment through the transition probabilities to change an opinion in a group of a given size. The idea is that if for example the market has observed a recent downturn, it will be easier for even a bearish minority to convince a bullish majority to change opinion compared to the case where the meeting takes place in a bullish upturn of the market. Within the framework of our proposed model, financial markets stylized facts such as volatility clustering and extreme events may be perceived as arising due to abrupt sentiment changes via ongoing communication of the market participants. The model introduces a new volatility measure which is apt of capturing volatility clustering and from maximum-likelihood analysis we are able to apply the model to real data and give additional long term insight into where a market is

  15. Derived enriched uranium market

    SciTech Connect

    Rutkowski, E.

    1996-12-01

    The potential impact on the uranium market of highly enriched uranium from nuclear weapons dismantling in the Russian Federation and the USA is analyzed. Uranium supply, conversion, and enrichment factors are outlined for each country; inventories are also listed. The enrichment component and conversion components are expected to cause little disruption to uranium markets. The uranium component of Russian derived enriched uranium hexafluoride is unresolved; US legislation places constraints on its introduction into the US market.

  16. Marketing Essentials for Continuing Education.

    ERIC Educational Resources Information Center

    Fong, Jim

    2001-01-01

    A survey of continuing education providers showed the need for greater investment in marketing, cultivation of outsourcing relationships, staff development in marketing techniques, and new ways of communicating the message to potential customers. (SK)

  17. Market study: Whole blood analyzer

    NASA Technical Reports Server (NTRS)

    1977-01-01

    A market survey was conducted to develop findings relative to the commercialization potential and key market factors of the whole blood analyzer which is being developed in conjunction with NASA's Space Shuttle Medical System.

  18. The Private Market for Long-Term Care Insurance in the U.S.: A Review of the Evidence

    PubMed Central

    Brown, Jeffrey R.; Finkelstein, Amy

    2009-01-01

    This paper reviews the growing literature on the market for private long-term care insurance, a market notable for its small size despite the fact that long-term care expenses are potentially large and highly uncertain. After summarizing long-term care utilization and insurance coverage in the United States, the paper reviews research on the supply of and the demand for private long-term care insurance. It concludes that demand-side factors impose important limits on the size of the private market and that we currently have a limited understanding of how public policies could be designed to encourage the growth of this market. PMID:20046809

  19. Antibiotic Resistance and Virulence Potentials of Shiga Toxin-Producing Escherichia coli Isolates from Raw Meats of Slaughterhouses and Retail Markets in Korea.

    PubMed

    Park, Hyun-Jung; Yoon, Jang Won; Heo, Eun-Jeong; Ko, Eun-Kyoung; Kim, Ki-Yeon; Kim, Young-Jo; Yoon, Hyang-Jin; Wee, Sung-Hwan; Park, Yong Ho; Moon, Jin San

    2015-09-01

    In this study, the prevalence of Shiga toxin-producing Escherichia coli (STEC) was investigated among raw meat or meat products from slaughterhouses and retail markets in South Korea, and their potential for antibiotic resistance and virulence was further analyzed. A total of 912 raw meats, including beef, pork, and chicken, were collected from 2008 to 2009. E. coli strains were frequently isolated in chicken meats (176/233, 75.9%), beef (102/217, 42.3%), and pork (109/235, 39.2%). Putative STEC isolates were further categorized, based on the presence or absence of the Shiga toxin (stx) genes, followed by standard O-serotyping. Polymerase chain reaction assays were used to detect the previously defined virulence genes in STEC, including Shiga toxins 1 and Shiga toxin 2 (stx1 and 2), enterohemolysin (ehxA), intimin (eaeA), STEC autoagglutination adhesion (saa), and subtilase cytotoxin (subAB). All carried both stx1 and eae genes, but none of them had the stx2, saa, or subAB genes. Six (50.0%) STEC isolates possessed the ehxA gene, which is known to be encoded by the 60-megadalton virulence plasmid. Our antibiogram profiling demonstrated that some STEC strains, particularly pork and chicken isolates, displayed a multiple drug-resistance phenotype. RPLA analysis revealed that all the stx1-positive STEC isolates produced Stx1 only at the undetectable level. Altogether, these results imply that the locus of enterocyte and effacement (LEE)-positive strains STEC are predominant among raw meats or meat products from slaughterhouses or retail markets in Korea.

  20. Human consumption as an invasive species management strategy. A preliminary assessment of the marketing potential of invasive Asian carp in the US.

    PubMed

    Varble, Sarah; Secchi, Silvia

    2013-06-01

    Over the past 20 years, Asian carp have invaded rivers and lakes in the Midwest and southern United States, with large negative impacts, such as encroachment on the habitat of native fish and mass die-off. They also respond to boat motors by jumping out of the water, which can cause harm to boaters and fishermen. Policymakers in the Great Lakes region between the US and Canada are worried about possible expansion of the Asian carp to their region and its effects on their fishing industry. A potential solution to the problem is to harvest Asian carp for human consumption. This study analyzes the results of the first national survey on the attitudes of US fish consumers towards Asian carp. We find that this is a potentially promising strategy. Most respondents would be willing to try a free sample of Asian carp and would be willing to pay for it. Because of the negative connotation attached to carp in general, this figure is encouraging. Creating demand for Asian carp could be a market based, cost-effective solution for a problem (invasive species) that is typically dealt with through command and control policies, if it is coupled with appropriate policies and safeguards to ensure the fish is eventually eradicated and not cultivated for profit after removal from US rivers and lakes.

  1. Size and CT density of iodine-containing ethosomal vesicles obtained by membrane extrusion: potential for use as CT contrast agents.

    PubMed

    Na, Bomin; Choi, Byoung Wook; Kim, Bumsang

    2013-11-01

    Computed tomography (CT) is the primary non-invasive imaging technique used for most patients with suspected liver disease. In order to improve liver-specific imaging properties and prevent toxic effects in patients with compromised renal function, we investigated the encapsulation of iodine within ethosomal vesicles. As a first step in the development of novel contrast agents using ethosomes for CT imaging applications, iodine was entrapped within ethosomes and iodine-containing ethosomes of the desired size were obtained by extrusion using a polycarbonate membrane with a defined pore size. Ethosomes containing iodine showed a relatively high CT density, which decreased when they were extruded, due to the rupture and re-formation of the lipid bilayer of the ethosome. However, when a solution with a high iodine concentration was used as a dispersion media during the extrusion process, the decrease in CT density could be prevented. In addition, ethosomes containing iodine were taken up efficiently by macrophages, which are abundant in the liver, and these ethosomes exhibited no cellular toxicity. These results demonstrate that iodine could be entrapped within ethosomal vesicles, giving the ethosomes a relatively high CT density, and that the extrusion technique used in this study could conveniently and reproducibly produce ethosomal vesicles with a desired size. Therefore, ethosomes containing iodine, as prepared in this study, have potential as contrast agents with applications in CT imaging.

  2. Predicting the influence of liposomal lipid composition on liposome size, zeta potential and liposome-induced dendritic cell maturation using a design of experiments approach.

    PubMed

    Soema, Peter C; Willems, Geert-Jan; Jiskoot, Wim; Amorij, Jean-Pierre; Kersten, Gideon F

    2015-08-01

    In this study, the effect of liposomal lipid composition on the physicochemical characteristics and adjuvanticity of liposomes was investigated. Using a design of experiments (DoE) approach, peptide-containing liposomes containing various lipids (EPC, DOPE, DOTAP and DC-Chol) and peptide concentrations were formulated. Liposome size and zeta potential were determined for each formulation. Moreover, the adjuvanticity of the liposomes was assessed in an in vitro dendritic cell (DC) model, by quantifying the expression of DC maturation markers CD40, CD80, CD83 and CD86. The acquired data of these liposome characteristics were successfully fitted with regression models, and response contour plots were generated for each response factor. These models were applied to predict a lipid composition that resulted in a liposome with a target zeta potential. Subsequently, the expression of the DC maturation factors for this lipid composition was predicted and tested in vitro; the acquired maturation responses corresponded well with the predicted ones. These results show that a DoE approach can be used to screen various lipids and lipid compositions, and to predict their impact on liposome size, charge and adjuvanticity. Using such an approach may accelerate the formulation development of liposomal vaccine adjuvants.

  3. Fine tuning of magnetite nanoparticle size distribution using dissymmetric potential pulses in the presence of biocompatible surfactants and the electrochemical characterization of the nanoparticles.

    PubMed

    Rodríguez-López, A; Cruz-Rivera, J J; Elías-Alfaro, C G; Betancourt, I; Ruiz-Silva, H; Antaño-López, R

    2015-01-01

    The effects of varying the surfactant concentration and the anodic pulse potential on the properties and electrochemical behaviors of magnetite nanoparticles were investigated. The nanoparticles were synthesized with an electrochemical method based on applying dissymmetric potential pulses, which offers the advantage that can be used to tune the particle size distribution very precisely in the range of 10 to 50 nm. Under the conditions studied, the surfactant concentration directly affects the size distribution, with higher concentrations producing narrower distributions. Linear voltammetry was used to characterize the electrochemical behavior of the synthesized nanoparticles in both the anodic and cathodic regions, which are attributed to the oxidation of Fe(2+) and the reduction of Fe(3+); these species are part of the spinel structure of magnetite. Electrochemical impedance spectroscopy data indicated that the reduction and oxidation reactions of the nanoparticles are not controlled by the mass transport step, but by the charge transfer step. The sample with the highest saturation magnetization was that synthesized in the presence of polyethylene glycol.

  4. Ion-Specific Modulation of Interfacial Interaction Potentials between Solid Substrates and Cell-Sized Particles Mediated via Zwitterionic, Super-Hydrophilic Poly(sulfobetaine) Brushes.

    PubMed

    Higaki, Yuji; Fröhlich, Benjamin; Yamamoto, Akihisa; Murakami, Ryo; Kaneko, Makoto; Takahara, Atsushi; Tanaka, Motomu

    2017-02-16

    Zwitterionic polymer brushes draw increasing attention not only because of their superhydrophilic, self-cleaning capability but also due to their excellent antifouling capacity. We investigated the ion-specific modulation of the interfacial interaction potential via densely packed, uniform poly(sulfobetaine) brushes. The vertical Brownian motion of a cell-sized latex particle was monitored by microinterferometry, yielding the effective interfacial interaction potentials V(Δh) and the autocorrelation function of height fluctuation. The potential curvature V″(Δh) exhibited a monotonic increase according to the increase in monovalent salt concentrations, implying the sharpening of the potential confinement. An opposite tendency was observed in CaCl2 solutions, suggesting that the ion specific modulation cannot be explained by the classical Hofmeister series. When the particle fluctuation was monitored in the presence of free sulfobetaine molecules, the increase in [sulfobetaine] resulted in a distinct increase in hydrodynamic friction. This was never observed in all the other salt solutions, suggesting the interference of zwitterionic pairing of sulfobetaine side chains by the intercalation of sulfobetaine molecules into the brush layer. Furthermore, poly(sulfobetaine) brushes exhibited a very low V″(Δh) and hydrodynamic friction to human erythrocytes, which seems to explain the excellent blood repellency of zwitterionic polymer materials.

  5. Elucidation of the mechanisms of action of Bacteriophage K/nano-emulsion formulations against S. aureus via measurement of particle size and zeta potential.

    PubMed

    Esteban, Patricia Perez; Jenkins, A Toby A; Arnot, Tom C

    2016-03-01

    In earlier work we have demonstrated the effect that nano-emulsions have on bacterial growth, and most importantly the enhanced bacteriophage infectivity against Staphylococcus aureus in planktonic culture when phage are carried in nano-emulsions. However, the mechanisms of enhancement of the bacteriophage killing effect are not specifically understood. This work focuses on the investigation of the possible interactions between emulsion droplets and bacterial cells, between emulsion droplets and bacteriophages, and finally interactions between all three components: nano-emulsion droplets, bacteria, and bacteriophages. The first approach consists of simple calculations to determine the spatial distribution of the components, based on measurements of particle size. It was found that nano-emulsion droplets are much more numerous than bacteria or bacteriophage, and due to their size and surface area they must be covering the surface of both cells and bacteriophage particles. Stabilisation of bacteriophages due to electrostatic forces and interaction with nano-emulsion droplets is suspected, since bacteriophages may be protected against inactivation due to 'charge shielding'. Zeta potential was measured for the individual components in the system, and for all of them combined. It was concluded that the presence of nano-emulsions could be reducing electrostatic repulsion between bacterial cells and bacteriophage, both of which are very negatively 'charged'. Moreover, nano-emulsions lead to more favourable interaction between bacteriophages and bacteria, enhancing the anti-microbial or killing effect. These findings are relevant since the physicochemical properties of nano-emulsions (i.e. particle size distribution and zeta potential) are key in determining the efficacy of the formulation against infection in the context of responsive burn wound dressings-which is the main target for this work.

  6. Software Marketing Considerations.

    ERIC Educational Resources Information Center

    Fuchs, Victor E.

    Seven factors that currently affect the potential for marketing and publishing computer software for education are discussed: (1) computers as an inplace technology in education, (2) marketing and distribution patterns for software, (3) consumer demand, (4) quality, (5) timelessenss, (6) basic skills, and (7) the future. The proliferation of…

  7. Marketing Schools for Survival

    ERIC Educational Resources Information Center

    Padgett, Raven

    2007-01-01

    Principals desiring recognition in the community have added marketing to their job description. Faced with falling enrollments and more school choice for parents, they create strategies to market and brand their schools to potential parents and students, from promoting programs in school newsletters and websites to direct mailings and ads in real…

  8. Marketing Your Program

    ERIC Educational Resources Information Center

    Anderson, Susan

    2009-01-01

    A marketing plan outlines the specific actions a person intends to carry out to interest potential customers in his/her service and to persuade them to buy the services he/she offers. In other words, a marketing plan defines what his/her organization will do to interest new families in his/her facility and encourage them to enroll their children…

  9. [Community marketing of contraceptives].

    PubMed

    Urrutia, J M

    1987-09-01

    The 5-year-old community contraceptive distribution program developed by PROFAMILIA, Colombia's private family planning organization, has given excellent results, but several cost-effectiveness comparisons with social marketing programs have suggested that commercial distribution programs are superior. The community contraceptive distribution program has a high content of information and education activities, which produced significant increases in knowledge and use of contraception in the communities covered. It has been a fundamental support for the social marketing program, creating much of the demand for contraceptive products that the social marketing program has filled. The social marketing program has given good results in terms of volume of sales and in cost-effectiveness since 1976, prompting calls for replacement of the community contraceptive distribution program by the social marketing program in those sectors where knowledge and use of contraception have achieved acceptable levels. An experiment in the Department of Santander in 1984 and 1985 gave very favorable results, suggesting that community contraceptive distribution programs should be replaced by social marketing programs in all more developed markets. But economic problems in 1985 and the decision of manufacturers to decrease the profit margin for PROFAMILIA jeopardized the social marketing program. The community distribution program covered about 20% of the market. Reduced profits in the social marketing program threatened its continued expansion, at the same time that potential demand was growing because of increases in the fertile aged population and increased use of contraception. To meet the need, PROFAMILIA combined the community contraceptive distribution and social marketing programs into a new entity to be called community marketing. The strategy of the community marketing program will be to maintain PROFAMILIA's participation in the market and aid the growth of demand for

  10. Hospital marketing.

    PubMed

    Carter, Tony

    2003-01-01

    This article looks at a prescribed academic framework for various criteria that serve as a checklist for marketing performance that can be applied to hospital marketing organizations. These guidelines are drawn from some of Dr. Noel Capon of Columbia University's book Marketing Management in the 21st Century and applied to actual practices of hospital marketing organizations. In many ways this checklist can act as a "marketing" balanced scorecard to verify performance effectiveness and develop opportunities for innovation.

  11. Strategic marketing in the UK tobacco industry.

    PubMed

    Anderson, Susan; Hastings, Gerard; MacFadyen, Lynn

    2002-08-01

    Tobacco-industry marketing has played a central part in the global spread of tobacco use and addiction. Although the absolute size of the tobacco market has dwindled, the industry is still immensely successful, largely due to sophisticated and manipulative marketing strategies. The UK tobacco industry identifies target groups and builds enduring relationships based on careful brand management. Potential customers are exposed to brands which are likely to appeal to them most. Tobacco companies tailor their products to target markets by altering the content of tar and nicotine, and by adding flavourings to produce a distinctive taste. Marketing strategies ensure that the products are promoted heavily at the point of sale, and directed advertising and sponsorship agreements are used to increase the visibility of the brand and strengthen its image. Tobacco companies also target non-consumer organisations such as retailers and policy makers with the aim of creating the best possible business environment for tobacco sales. We review published evidence, internal-advertising-agency documents, and observational data about tobacco promotion, and discuss the use of targeted marketing strategies in the UK.

  12. Selling green power in California: Product, industry, and market trends

    SciTech Connect

    Wiser, R.H.; Pickle, S.J.

    1998-05-01

    As one of the first US stages to open its doors to retail electric competition, California offers an important opportunity to assess the effectiveness of green power marketing as a mechanism for supporting renewable energy. This report is an interim assessment of key green power product, industry, and market trends in California. The report identifies and analyzes: the potential size of the green power market in California; the companies participating in the green power market; the green power products being offered and their prices; the impact of the green market on renewable generators and the environment; and the influence of several public policies and non-governmental programs on the market for green power. Data used in this paper have been collected, in large part, from surveys and interviews with green power marketers that took place between December 1997 and April 1998. There remain legitimate concerns over the viability of green power marketing to support significant quantities of renewable energy and provide large environmental gains, and it is far too early to assess the overall strength of customer demand for renewable energy. A critical finding of this report is that, because of the high cost of acquiring and servicing residential customers and the low utility default service price, green power marketing affords new energy service providers one of the only viable entrees to California`s residential marketplace.

  13. The EEC Electronic Information Services Market.

    ERIC Educational Resources Information Center

    Westhoff, Jurgen

    1993-01-01

    Describes the European Information Market Observatory and its purpose of gathering and providing knowledge about the European electronic information services market. Topics include the supply and use of electronic information services, size of the market, structure and policy of market operators, and recent developments in new electronic…

  14. Market-based demand forecasting promotes informed strategic financial planning.

    PubMed

    Beech, A J

    2001-11-01

    Market-based demand forecasting is a method of estimating future demand for a healthcare organization's services by using a broad range of data that describe the nature of demand within the organization's service area. Such data include the primary and secondary service areas, the service-area populations by various demographic groupings, discharge utilization rates, market size, and market share by service line and organizationwide. Based on observable market dynamics, strategic planners can make a variety of explicit assumptions about future trends regarding these data to develop scenarios describing potential future demand. Financial planners then can evaluate each scenario to determine its potential effect on selected financial and operational measures, such as operating margin, days cash on hand, and debt-service coverage, and develop a strategic financial plan that covers a range of contingencies.

  15. Market Potential of Downtown Cheyenne

    DTIC Science & Technology

    1985-02-01

    merchants to draw customers past the convenient, well-designed and well-stocked shopping mall , something unique must be provided.Downtown Cheyenne...traffic signal pattern hampers the pedestrian oriented shopping experience. 0 ou P Bridges and W Although downtown Cheyenne will not be an enclosed mall ...ability to draw from a larger trade area than traditionally shopped in Laramie County. . Food store sales which represented 23 to 25 percent of total

  16. Oxidative potential and chemical speciation of size-resolved particulate matter (PM) at near-freeway and urban background sites in the greater Beirut area.

    PubMed

    Daher, Nancy; Saliba, Najat A; Shihadeh, Alan L; Jaafar, Malek; Baalbaki, Rima; Shafer, Martin M; Schauer, James J; Sioutas, Constantinos

    2014-02-01

    To assess particle oxidative potential in the greater Beirut area, size-resolved PM10-2.5, PM2.5-0.25 and PM0.25 samples were collected at near-freeway and urban background sites. Metals and trace elements, including Mn, Cr, Cu, Ba, Mo and Sb, displayed increased levels and crustal enrichment factors at the roadway, indicating their vehicular origin. These elements in addition to Co, V, Ni and Zn were mostly distributed in PM2.5-0.25 and PM0.25 at both sites, with moderate-to-high water-solubility (>30%). The presence of these metals, mainly air toxics, in small size ranges constitutes an added health risk. Of particular concern are elements with strong correlations (R ≥ 0.70) with reactive oxygen species (ROS)-activity, measured by a cellular assay. In PM10-2.5, road dust component Mn and soil-related element Co were highly correlated with ROS-activity. In PM2.5-0.25, vehicular abrasion element Cu and soil-derived component Co were highly associated with ROS-activity. In PM0.25, V and Ni, originating from fuel oil combustion, strongly correlated with ROS formation. ROS-activity displayed a particle-size dependency, with lowest activity associated with PM10-2.5. On a per air volume basis, size-resolved ROS-activity was 1.5-2.8 times greater at the roadside than background location, indicating that exposure to redox-active species may be greatest near the freeway. Size-fractionated PM intrinsic activity (i.e. PM mass-normalized) was comparable at both sites, possibly suggesting a similarity in the sources of ROS-active species. Relative to other urban settings, while the intrinsic redox activity of PM10-2.5 in Beirut is comparable to that measured at an urban site in Los Angeles (LA), its PM0.25-induced ROS-activity is ~2.3-fold greater. Moreover, the intrinsic ROS-activity of ambient PM2.5 in Beirut is comparable to that reported in Milan-Italy, but 3.1-times PM2.5 activity in the heavily-polluted Lahore-Pakistan. Lastly, findings suggest a dominant role of

  17. Neuromodulation at single presynaptic boutons of cerebellar parallel fibers is determined by bouton size and basal action potential-evoked Ca transient amplitude

    PubMed Central

    Zhang, Wei; Linden, David J.

    2010-01-01

    Most presynaptic terminals in the brain contain G-protein coupled receptors that function to reduce action potential-evoked neurotransmitter release. These neuromodulatory receptors, including those for glutamate, GABA, endocannabinoids and adenosine, exert a substantial portion of their effect by reducing evoked presynaptic Ca2+ transients. Many axons form synapses with multiple postsynaptic neurons, but it is unclear if presynaptic attenuation in these synapses is homogeneous, as suggested by population level Ca2+ imaging. We loaded Ca2+-sensitive dyes into cerebellar parallel fiber axons and imaged action potential-evoked Ca2+ transients in individual presynaptic boutons with application of three different neuromodulators and found that adjacent boutons on the same axon showed striking heterogeneity in their strength of attenuation. Moreover, attenuation was predicted by bouton size or basal Ca2+ response: smaller boutons were more sensitive to adenosine A1 agonist but less sensitive to CB1 agonist while boutons with high basal action potential-evoked Ca2+ transient amplitude were more sensitive to mGluR4 agonist. These results suggest that boutons within brief segment of a single parallel fiber axon can have different sensitivities towards neuromodulators and may have different capacities for both short-term and long-term plasticities. PMID:20007482

  18. Assessing the market opportunities of landfill mining.

    PubMed

    van der Zee, D J; Achterkamp, M C; de Visser, B J

    2004-01-01

    Long-term estimates make clear that the amount of solid waste to be processed at landfills in the Netherlands will sharply decline in coming years. Major reasons can be found in the availability of improved technologies for waste recycling and government regulations aiming at waste reduction. Consequently, market size for companies operating landfills shrinks. Among the companies facing the problem is the Dutch company Essent. Given the expected market conditions, it looks for alternative business opportunities. Landfill mining, i.e., the recycling of existing landfills, is considered one of them. Proceeds of landfill mining are related to, for example, recycled materials available for re-use, regained land, and possibilities for a more efficient operation of a landfill. The market for landfill mining is of a considerable size--there are about 3800 landfills located in the Netherlands. Given market size the company faces the dilemma of how to explore this market, i.e., select the most profitable landfills in a fast and efficient way. No existing methods or tools could be found to do so. Therefore, to answer to the problem posed, we propose a step-wise research method for market exploration. The basic idea behind the method is to provide an adequate, cost-saving and timely answer by relying on a series of quick scans. Relevant aspects of a mining project concern the proceeds of regained land and recyclables, the costs of the mining operation and the associated business and environmental risks. The method has been tested for its practical use in a pilot study. The pilot study addressed 147 landfills located in the Dutch Province of Noord-Brabant. The study made clear how method application resulted in the selection of a limited number of high potential landfills in a few weeks, involving minimal research costs.

  19. The effects of a geometrical size, external electric fields and impurity on the optical gain of a quantum dot laser with a semi-parabolic spherical well potential

    NASA Astrophysics Data System (ADS)

    Owji, Erfan; Keshavarz, Alireza; Mokhtari, Hosein

    2017-03-01

    In this paper, a GaAs / Alx Ga1-x As quantum dot laser with a semi-parabolic spherical well potential is assumed. By using Runge-Kutta method the eigenenergies and the eigenstates of valence and conduct bands are obtained. The effects of geometrical sizes, external electric fields and hydrogen impurity on the different electronic transitions of the optical gain are studied. The results show that the optical gain peak increases and red-shifts, by increasing the width of well or barrier, while more increasing of the width causes blue-shift and decreases it. The hydrogen impurity decreases the optical gain peak and blue-shifts it. Also, the increasing of the external electric fields cause to increase the peak of the optical gain, and (blue) red shift it. Finally, the optical gain for 1s-1s and 2s-1s transitions is prominent, while it is so weak for other transitions.

  20. Nurse education in competitive markets: the case for relationship marketing.

    PubMed

    Roberts, P M

    1998-10-01

    Since the National Health Service reforms of the late 1980s, nurse education has been increasingly subject to market forces. This new competitive environment presents not only threat, but also challenge and opportunity. Providers of nurse education who recognize the need for market orientation and develop responsive marketing strategies will maximize their potential for market retention and growth. Traditional marketing strategies have considerable limitations for public sector services. The new and growing field of relationship marketing offers nurse education an opportunity to retain and develop profitable relationships with both internal and external markets. This paper reviews the marketing arena in nurse education and proposes context-based qualitative research to ascertain definitive constructs of service quality. Such constructs might then be rooted in a theoretical framework of service quality measurement, and be measured within the disconfirmation paradigm of relationship marketing.

  1. Marketing fundamentals.

    PubMed

    Redmond, W H

    2001-01-01

    This chapter outlines current marketing practice from a managerial perspective. The role of marketing within an organization is discussed in relation to efficiency and adaptation to changing environments. Fundamental terms and concepts are presented in an applied context. The implementation of marketing plans is organized around the four P's of marketing: product (or service), promotion (including advertising), place of delivery, and pricing. These are the tools with which marketers seek to better serve their clients and form the basis for competing with other organizations. Basic concepts of strategic relationship management are outlined. Lastly, alternate viewpoints on the role of advertising in healthcare markets are examined.

  2. Public health potential of farmers' markets on medical center campuses: a case study from Penn State Milton S. Hershey Medical Center.

    PubMed

    George, Daniel R; Kraschnewski, Jennifer L; Rovniak, Liza S

    2011-12-01

    There are currently 7175 farmers' markets in the United States, and these organizations are increasingly viewed as one facet of the solution to national health problems. There has been a recent trend toward establishing markets on medical center campuses, and such partnerships can augment a medical center's ability to serve community health. However, to our knowledge no studies have described the emergence of a market at a medical center, the barriers and challenges such an initiative has faced, or the nature of programming it may foster. We provide a qualitative description of the process of starting a seasonal, once-a-week, producers-only market at the Pennsylvania State Hershey Medical Center, and we call for greater public health attention to these emerging community spaces.

  3. Public Health Potential of Farmers’ Markets on Medical Center Campuses: A Case Study From Penn State Milton S. Hershey Medical Center

    PubMed Central

    Kraschnewski, Jennifer L.; Rovniak, Liza S.

    2011-01-01

    There are currently 7175 farmers’ markets in the United States, and these organizations are increasingly viewed as one facet of the solution to national health problems. There has been a recent trend toward establishing markets on medical center campuses, and such partnerships can augment a medical center's ability to serve community health. However, to our knowledge no studies have described the emergence of a market at a medical center, the barriers and challenges such an initiative has faced, or the nature of programming it may foster. We provide a qualitative description of the process of starting a seasonal, once-a-week, producers-only market at the Pennsylvania State Hershey Medical Center, and we call for greater public health attention to these emerging community spaces. PMID:22021298

  4. Rats and Seabirds: Effects of Egg Size on Predation Risk and the Potential of Conditioned Taste Aversion as a Mitigation Method

    PubMed Central

    Latorre, Lucía; Larrinaga, Asier R.; Santamaría, Luis

    2013-01-01

    Seabirds nesting on islands are threatened by invasive rodents, such as mice and rats, which may attack eggs, chicks and even adults. The low feasibility of rat eradications on many islands makes the development of alternate control plans necessary. We used a combination of field experiments on a Mediterranean island invaded by black rats (Rattusrattus) to evaluate (1) the predation risk posed to different-sized seabird eggs and (2), the potential of two deterrent methods (electronic and chemical) to reduce its impact. Rats were able to consume eggs of all sizes (12 to 68 g), but survival increased 13 times from the smallest to the largest eggs (which also had more resistant eggshells). Extrapolation to seabird eggs suggests that the smallest species (Hydrobatespelagicus) suffer the most severe predation risk, but even the largest (Larusmichahellis) could suffer >60% mortality. Nest attack was not reduced by the deterrents. However, chemical deterrence (conditioned taste aversion by lithium chloride) slowed the increase in predation rate over time, which resulted in a three-fold increase in egg survival to predation as compared to both control and electronic deterrence. At the end of the experimental period, this effect was confirmed by a treatment swap, which showed that conferred protection remains at least 15 days after cessation of the treatment. Results indicate that small seabird species are likely to suffer severe rates of nest predation by rats and that conditioned taste aversion, but not electronic repellents, may represent a suitable method to protect colonies when eradication or control is not feasible or cost-effective. PMID:24058712

  5. Predicting Consumer Biomass, Size-Structure, Production, Catch Potential, Responses to Fishing and Associated Uncertainties in the World’s Marine Ecosystems

    PubMed Central

    Jennings, Simon; Collingridge, Kate

    2015-01-01

    Existing estimates of fish and consumer biomass in the world’s oceans are disparate. This creates uncertainty about the roles of fish and other consumers in biogeochemical cycles and ecosystem processes, the extent of human and environmental impacts and fishery potential. We develop and use a size-based macroecological model to assess the effects of parameter uncertainty on predicted consumer biomass, production and distribution. Resulting uncertainty is large (e.g. median global biomass 4.9 billion tonnes for consumers weighing 1 g to 1000 kg; 50% uncertainty intervals of 2 to 10.4 billion tonnes; 90% uncertainty intervals of 0.3 to 26.1 billion tonnes) and driven primarily by uncertainty in trophic transfer efficiency and its relationship with predator-prey body mass ratios. Even the upper uncertainty intervals for global predictions of consumer biomass demonstrate the remarkable scarcity of marine consumers, with less than one part in 30 million by volume of the global oceans comprising tissue of macroscopic animals. Thus the apparently high densities of marine life seen in surface and coastal waters and frequently visited abundance hotspots will likely give many in society a false impression of the abundance of marine animals. Unexploited baseline biomass predictions from the simple macroecological model were used to calibrate a more complex size- and trait-based model to estimate fisheries yield and impacts. Yields are highly dependent on baseline biomass and fisheries selectivity. Predicted global sustainable fisheries yield increases ≈4 fold when smaller individuals (< 20 cm from species of maximum mass < 1kg) are targeted in all oceans, but the predicted yields would rarely be accessible in practice and this fishing strategy leads to the collapse of larger species if fishing mortality rates on different size classes cannot be decoupled. Our analyses show that models with minimal parameter demands that are based on a few established ecological principles

  6. Electricity market design for the prosumer era

    NASA Astrophysics Data System (ADS)

    Parag, Yael; Sovacool, Benjamin K.

    2016-04-01

    Prosumers are agents that both consume and produce energy. With the growth in small and medium-sized agents using solar photovoltaic panels, smart meters, vehicle-to-grid electric automobiles, home batteries and other ‘smart’ devices, prosuming offers the potential for consumers and vehicle owners to re-evaluate their energy practices. As the number of prosumers increases, the electric utility sector of today is likely to undergo significant changes over the coming decades, offering possibilities for greening of the system, but also bringing many unknowns and risks that need to be identified and managed. To develop strategies for the future, policymakers and planners need knowledge of how prosumers could be integrated effectively and efficiently into competitive electricity markets. Here we identify and discuss three promising potential prosumer markets related to prosumer grid integration, peer-to-peer models and prosumer community groups. We also caution against optimism by laying out a series of caveats and complexities.

  7. Capacity Markets and Market Stability

    SciTech Connect

    Stauffer, Hoff

    2006-04-15

    The good news is that market stability can be achieved through a combination of longer-term contracts, auctions for far enough in the future to permit new entry, a capacity management system, and a demand curve. The bad news is that if and when stable capacity markets are designed, the markets may seem to be relatively close to where we started - with integrated resource planning. Market ideologues will find this anathema. (author)

  8. Developing Market Opportunities for Flexible Rooftop Applications of PV Using Flexible CIGS Technology: Market Considerations

    SciTech Connect

    Sabnani, L.; Skumanich, A.; Ryabova, E.; Noufi, R.

    2011-01-01

    There has been a recent upsurge in developments for building-integrated phototovoltaics (BiPV) roof top materials based on CIGS. Several new companies have increased their presence and are looking to bring products to market for this application in 2011. For roof-top application, there are significant key requirements beyond just having good conversion efficiency. Other attributes include lightweight, as well as moisture-proof, and fully functionally reliable. The companies bringing these new BIPV/BAPV products need to ensure functionality with a rigorous series of tests, and have an extensive set of 'torture' tests to validate the capability. There is a convergence of form, aesthetics, and physics to ensure that the CIGS BiPV deliver on their promises. This article will cover the developments in this segment of the BiPV market and delve into the specific tests and measurements needed to characterize the products. The potential market sizes are evaluated and the technical considerations developed.

  9. Assessment of regeneration potential in the clonal macrophyte Miscanthus sacchariflorus (Poaceae) after burial disturbance based on bud bank size and sprouting capacity.

    PubMed

    Chen, Xinsheng; Cao, Chenshu; Deng, Zhengmiao; Xie, Yonghong; Li, Feng; Hou, Zhiyong; Li, Xu

    2015-01-01

    The demography of the bud bank and its sprouting capacity are important for understanding the population dynamics of clonal plants and their potential responses to disturbances. To this end, we investigated the size and composition of the bud bank of Miscanthus sacchariflorus (Maxim.) Hack. immediately after flooding (November), in winter (January), in spring (March), and before flooding (May) in the wetlands of Dongting Lake. We then examined the sprouting capacity of axillary buds after sediment burial at 0, 5, 10, 15, and 20 cm. Total bud density of M. sacchariflorus ranged from 2524 buds m(-2) in November to 4293 buds m(-2) in March. Rhizome segments with inactive axillary buds, which represented the majority of the bud population (88.7% in November, 93.3% in May), did not sprout during the 140 days of the experiment (n = 250). The sprouting ratio was the highest for active axillary buds buried at 0 cm (64%) and decreased when buried at 10-20 cm (34%-40%). Due to the large number of active axillary buds in the bud bank (211-277 buds m(-2) from November to the following March), M. sacchariflorus could completely replace its aboveground shoot population, except in May (142 buds m(-2)). Increasing burial depth delayed bud emergence and reduced the growth period of shoots; however, burial depth did not affect the resulting plant height and only reduced the accumulated biomass at 20 cm. Therefore, the belowground bud bank and its strong sprouting capacity are important factors in the maintenance of local populations and colonization of new habitats for M. sacchariflorus after burial disturbances. The present methodology, which combined measurements of bud bank demography and sprouting capacity, may reflect the regeneration potential of clonal plants after burial disturbances.

  10. Elemental selenium at nano size (Nano-Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: comparison with se-methylselenocysteine in mice.

    PubMed

    Zhang, Jinsong; Wang, Xufang; Xu, Tongwen

    2008-01-01

    Selenium (Se) is an essential trace element with a narrow margin between beneficial and toxic effects. As a promising chemopreventive agent, its use requires consumption over the long term, so the toxicity of Se is always a crucial concern. Based on clinical findings and recent studies in selenoprotein gene-modified mice, it is likely that the antioxidant function of one or more selenoproteins is responsible for the chemopreventive effect of Se. Furthermore, upregulation of phase 2 enzymes by Se has been implicated as a possible chemopreventive mechanism at supranutritional dietary levels. Se-methylselenocysteine (SeMSC), a naturally occurring organic Se product, is considered as one of the most effective chemopreventive selenocompounds. The present study revealed that, as compared with SeMSC, elemental Se at nano size (Nano-Se) possessed equal efficacy in increasing the activities of glutathione peroxidase, thioredoxin reductase, and glutathione S-transferase, but had much lower toxicity as indicated by median lethal dose, acute liver injury, survival rate, and short-term toxicity. Our results suggest that Nano-Se can serve as a potential chemopreventive agent with reduced risk of Se toxicity.

  11. Change of electrostatic potential of mean force between two curved surfaces due to different salt composition, ion valence and size under certain ionic strength

    NASA Astrophysics Data System (ADS)

    Zhou, Shiqi

    2016-02-01

    Change of an electrostatic potential of mean force (EPMF) between two cylindrical rod surfaces with salt composition, ion valence, and ion size at a constant ionic strength of 0.3 M is studied by a classical density functional theory (CDFT) in a primitive model electrolyte solution. Several novel observations are made: (i) strength of a so-called like charge attraction (LCA) reduces in an invariable manner with the salt solution changing from single 2:1 electrolyte to mixture of 2:1 and 1:1 type electrolytes of varying concentration ratios; the change is even over entire range of the composition variation under low surface charge strength, and tends to be insensitive to the composition variation in the presence of the divalent counter-ion, and more and more drastic at a critical point the divalent counter-ion disappears, respectively, as the surface charge strength becomes big enough. (ii) Both monovalent counter-ion and co-ion diameters have only a marginal effect on both the LCA strength and equilibrium distance, and the former "abnormally" affects less than the latter. (iii) Depending on the surface charge strength considered, the divalent counter-ion diameter influences the LCA strength in solution comprised of 2:1 type and 1:1 type electrolytes, monotonously or non-monotonously. All of these findings provide forceful support for a recently proposed hydrogen-bonding style mechanism explaining the LCA.

  12. Hydrogen Infrastructure Market Readiness: Opportunities and Potential for Near-term Cost Reductions; Proceedings of the Hydrogen Infrastructure Market Readiness Workshop and Summary of Feedback Provided through the Hydrogen Station Cost Calculator

    SciTech Connect

    Melaina, M. W.; Steward, D.; Penev, M.; McQueen, S.; Jaffe, S.; Talon, C.

    2012-08-01

    Recent progress with fuel cell electric vehicles (FCEVs) has focused attention on hydrogen infrastructure as a critical commercialization barrier. With major automakers focused on 2015 as a target timeframe for global FCEV commercialization, the window of opportunity is short for establishing a sufficient network of hydrogen stations to support large-volume vehicle deployments. This report describes expert feedback on the market readiness of hydrogen infrastructure technology from two activities.

  13. Nonwork and off-peak trips by transit, walk and bicycle modes: An understanding of existing and potential markets. Final report, 1 August 1996--28 February 1998

    SciTech Connect

    Soeoet, S.; Sen, A.; Yang, D.; Dirks, L.; Sternberg, T.

    1999-03-01

    The study identifies the characteristics of neighborhoods that contribute to off-peak transit, walk or bike use. The emphasis is on off-peak and nonwork trips and how to promote modes other than the automobile. By producing thirty maps illustrating socioeconomic and travel behavior patterns in the Chicago area, the potential for stabilizing and then increasing the utilization of these modes is examined. Substantial amounts of data were processed and reported. For example, off-peak trips, accounting for 48% of daily travel, are shorter than trips during the peak (in miles and minutes) for travel by both public transit and by private vehicle. Regionally, walking trips vary from 42% of all trips made by Chicago CBD residents (mainly to shop and work), 17% in the rest of the city and less than 5% in suburban Chicago. Bicycle ownership is related to the number of vehicles in the household, household income, household size and distance from the Chicago CBD. These data and field observations of three case-study neighborhoods revealed that differences in modes used are related to the land-use patterns and the socioeconomic characteristics of the resident population. While areas with low automobile ownership rates might suggest walking and bicycling, these nonmotorized modes are more common in affluent neighborhoods with a large number of nearby commercial and recreational destinations.

  14. Getting Ready for the Market Economy.

    ERIC Educational Resources Information Center

    Rudich, Kenneth S.

    2000-01-01

    A market intelligence database is a vital tool for continuing education providers and brokers. Its components are as follows: layout of potential markets; analysis of population, demand, environment, and competitors (market opportunities analysis); market performance measures; and college consumer trends. (SK)

  15. Potential health risk for residents around a typical e-waste recycling zone via inhalation of size-fractionated particle-bound heavy metals.

    PubMed

    Huang, Chun-Li; Bao, Lian-Jun; Luo, Pei; Wang, Zhao-Yi; Li, Shao-Meng; Zeng, Eddy Y

    2016-11-05

    Health risk of residents dwelling around e-waste recycling zones has been a global concern, but has not been adequately examined. The present study was intended to evaluate the potential health risk of residents through inhalation exposure to size-fractionated particle-bound heavy metals in a typical e-waste recycling zone, South China. Anthropogenic metals (Zn, Se, Pb, Sb, As, and Cd) were predominantly enriched in fine particles (Dp<1.8μm), whereas the crustal elements (Ti, Fe, and Co) tended to accumulate in coarse particles (Dp>1.8μm). Although the daily inhalation intakes of the target metals were significantly lower than those through food consumption and ingestion of house dust, the hazard quotients of total metals for adults (95% CI: 1.0-5.5) and children (95% CI: 3.0-17) were greater than 1. Moreover, the incremental lifetime cancer risks of five carcinogenic metals (Cr, Co, Ni, As, and Cd) for adults and children were 1.3×10(-3) (95% CI: 4.1×10(-4)-3.0×10(-3)) and 3.9×10(-3) (95% CI: 1.3×10(-3)-8.6×10(-3)), respectively, substantially higher than the acceptable cancer risk range of 10(-6)-10(-4). All these findings suggested that health risks were high for local residents dwelling around the e-waste recycling zone through inhalation exposure to particle-bound heavy metals, for both adults and children.

  16. Potential Activity, Size, and Structure of Sulfate-Reducing Microbial Communities in an Exposed, Grazed and a Sheltered, Non-Grazed Mangrove Stand at the Red Sea Coast

    PubMed Central

    Balk, Melike; Keuskamp, Joost A.; Laanbroek, Hendrikus J.

    2015-01-01

    After oxygen, sulfate is the most important oxidant for the oxidation of organic matter in mangrove forest soils. As sulfate reducers are poor competitors for common electron donors, their relative success depends mostly on the surplus of carbon that is left by aerobic organisms due to oxygen depletion. We therefore hypothesized that sulfate-cycling in mangrove soils is influenced by the size of net primary production, and hence negatively affected by mangrove degradation and exploitation, as well as by carbon-exporting waves. To test this, we compared quantitative and qualitative traits of sulfate-reducing communities in two Saudi-Arabian mangrove stands near Jeddah, where co-occurring differences in camel-grazing pressure and tidal exposure led to a markedly different stand height and hence primary production. Potential sulfate reduction rates measured in anoxic flow-through reactors in the absence and presence of additional carbon sources were significantly higher in the samples from the non-grazed site. Near the surface (0–2 cm depth), numbers of dsrB gene copies and culturable cells also tended to be higher in the non-grazed sites, while these differences were not detected in the sub-surface (4–6 cm depth). It was concluded that sulfate-reducing microbes at the surface were indeed repressed at the low-productive site as could be expected from our hypothesis. At both sites, sulfate reduction rates as well as numbers of the dsrB gene copies and viable cells increased with depth suggesting repression of sulfate reduction near the surface in both irrespective of production level. Additionally, sequence analysis of DNA bands obtained from DGGE gels based on the dsrB gene, showed a clear difference in dominance of sulfate-reducing genera belonging to the Deltaproteobacteria and the Firmicutes between sampling sites and depths. PMID:26733999

  17. Carbon storage potential in size-density fractions from semi-natural grassland ecosystems with different productivities over varying soil depths.

    PubMed

    Breulmann, Marc; Boettger, Tatjana; Buscot, François; Gruendling, Ralf; Schulz, Elke

    2016-03-01

    Researchers have increasingly recognised a profound need for more information on SOC stocks in the soil and the factors governing their stability and dynamics. Many questions still remain unanswered about the interplay between changes in plant communities and the extent to which changes in aboveground productivity affect the carbon dynamics in soils through changes in its quantity and quality. Therefore, the main aim of this research was to examine the SOC accumulation potential of semi-natural grasslands of different productivities and determine the distribution of SOM fractions over varying soil depth intervals (0-10, 10-20, 20-30 30-50 50-80 and 80+cm). SOM fractionation was considered as a relative measure of stability to separate SOM associated with clay minerals from SOM of specific light densities less than 2 g cm(-3) (size-density fractionation). Two clay-associated fractions (CF1, <1 μm; and CF2, 1-2 μm) and two light fractions (LF1, <1.8 g cm(-3); and LF2, 1.8-2.0 g cm(-3)) were separated. The stability of these fractions was characterised by their carbon hot water extractability (CHWE) and stable carbon isotope composition. In the semi-natural grasslands studied, most OC was stored in the top 30 cm, where turnover is rapid. Effects of low productivity grasslands became only significantly apparent when fractional OC contributions of total SOM was considered (CF1 and LF1). In deeper soil depths OC was largely attributed to the CF1 fraction of low productivity grasslands. We suggest that the majority of OM in deeper soil depth intervals is microbially-derived, as evidenced by decreasing C/N ratios and decreasing δ(13)C values. The hot water extraction and natural δ(13)C abundance, employed here allowed the characterisation of SOM stabilisation properties, however how climatic changes affect the fate of OM within different soil depth intervals is still unknown.

  18. Marketing Education

    ERIC Educational Resources Information Center

    Stancil, Ronald A., Sr.

    2008-01-01

    This article discusses the Marketing Education program at West Haven (CT) High School in West Haven, Connecticut, that promotes skills for life and attributes, enhances the academic program, and develops leaders out of ordinary students through an interactive curriculum. The three components of West Haven's marketing and management program are (1)…

  19. Marketing Training

    NASA Technical Reports Server (NTRS)

    Leonard, Eric

    1998-01-01

    All of our ideas have been field tested and have proven effective in our environment. Our objectives are: We will share our ideas about marketing training and what we've implemented at Michoud Space Systems. You will go away with at least one new idea or insight about how to more effectively market your training.

  20. Agricultural Marketing.

    ERIC Educational Resources Information Center

    Helt, Lawrence; And Others

    Designed for use in farm business management adult programs, this marketing curriculum includes six teaching lessons and professional staff products. The following topics are covered in the lessons: introduction to marketing; interpretation of price/demand/supply cycles and fundamental outlook trends (carryover/projections/disappearance); farmers'…

  1. Tourism Marketing.

    ERIC Educational Resources Information Center

    North Carolina State Dept. of Public Instruction, Raleigh. Div. of Vocational Education.

    This document contains teacher materials for a 6-unit, 1-year distributive education course in marketing tourism offered in grades 11 and 12 in North Carolina. Although in general the material presented concerns marketing tourism anywhere, some of it is specifically related to tourism within North Carolina. A purpose statement explains the…

  2. Nanotechnology in medicine: from inception to market domination.

    PubMed

    Morigi, Valentina; Tocchio, Alessandro; Bellavite Pellegrini, Carlo; Sakamoto, Jason H; Arnone, Marco; Tasciotti, Ennio

    2012-01-01

    Born from the marriage of nanotechnology and medicine, nanomedicine is set to bring advantages in the fight against unmet diseases. The field is recognized as a global challenge, and countless worldwide research and business initiatives are in place to obtain a significant market position. However, nanomedicine belongs to those emerging sectors in which business development methods have not been established yet. Open issues include which type of business model best fits these companies and which strategies would lead them to sustained growth. This paper describes the financial and strategic decisions by nanomedicine start-ups to reach the market successfully, obtain a satisfactory market share, and build and maintain a competitive defendable advantage. Walking nanomedicine-product from the hands of the inventor to those of the doctor, we explored the technological transfer process, which connects laboratories or research institutions to the marketplace. The process involves detailed analysis to evaluate the potentials of end-products, and researches to identify market segment, size, structure, and competitors, to ponder a possible market entry and the market share that managers can realistically achieve at different time horizons. Attracting funds is crucial but challenging. However, investors are starting to visualize the potentials of this field, magnetized by the business of "nano."

  3. 7 CFR 993.515 - Size categories.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Size categories. 993.515 Section 993.515 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... respective size categories expressed as follows or in an applicable equivalent range expressed in the...

  4. North American Natural Gas Markets. Volume 1

    SciTech Connect

    Not Available

    1988-12-01

    This report sunnnarizes the research by an Energy Modeling Forum working group on the evolution of the North American natural gas markets between now and 2010. The group`s findings are based partly on the results of a set of economic models of the natural gas industry that were run for four scenarios representing significantly different conditions: two oil price scenarios (upper and lower), a smaller total US resource base (low US resource case), and increased potential gas demand for electric generation (high US demand case). Several issues, such as the direction of regulatory policy and the size of the gas resource base, were analyzed separately without the use of models.

  5. Targeted marketing and public health.

    PubMed

    Grier, Sonya A; Kumanyika, Shiriki

    2010-01-01

    Targeted marketing techniques, which identify consumers who share common needs or characteristics and position products or services to appeal to and reach these consumers, are now the core of all marketing and facilitate its effectiveness. However, targeted marketing, particularly of products with proven or potential adverse effects (e.g., tobacco, alcohol, entertainment violence, or unhealthful foods) to consumer segments defined as vulnerable raises complex concerns for public health. It is critical that practitioners, academics, and policy makers in marketing, public health, and other fields recognize and understand targeted marketing as a specific contextual influence on the health of children and adolescents and, for different reasons, ethnic minority populations and other populations who may benefit from public health protections. For beneficial products, such understanding can foster more socially productive targeting. For potentially harmful products, understanding the nature and scope of targeted marketing influences will support identification and implementation of corrective policies.

  6. The potential of asymmetric flow field-flow fractionation hyphenated to multiple detectors for the quantification and size estimation of silica nanoparticles in a food matrix.

    PubMed

    Heroult, Julien; Nischwitz, Volker; Bartczak, Dorota; Goenaga-Infante, Heidi

    2014-06-01

    This work represents a first systematic approach to the size-based elemental quantification and size estimation of metal(loid) oxide nanoparticles such as silica (SiO2) in a real food matrix using asymmetric flow field-flow fractionation coupled online with inductively coupled plasma mass spectrometry (ICP-MS) and multi-angle light scattering (MALS) and offline with transmission electron microscopy (TEM) with energy-dispersive X-ray analysis (EDAX). Coffee creamer was selected as the model sample since it is known to contain silica as well as metal oxides such as titania at the milligramme per kilogramme levels. Optimisation of sample preparation conditions such as matrix-to-solvent ratio, defatting with organic solvents and sonication time that may affect nanoparticle size and size distribution in suspensions was investigated. Special attention was paid to the selection of conditions that minimise particle transformation during sample preparation and analysis. The coffee creamer matrix components were found to stabilise food grade SiO2 particles in comparison with water suspensions whilst no significant effect of defatting using hexane was found. The use of sample preparation procedures that mimic food cooking in real life was also investigated regarding their effect on particle size and particle size distribution of silica nanoparticles in the investigated food matrix; no significant effect of the water temperature ranging from ambient temperature to 60 °C was observed. Field-flow fractionation coupled to inductively coupled plasma-mass spectrometry (FFF-ICP-MS) analysis of extracts of both unspiked coffee creamer and coffee creamer spiked with food grade silicon dioxide, using different approaches for size estimation, enabled determination of SiO2 size-based speciation. Element-specific detection by ICP-MS and post-FFF calibration with elemental calibration standards was used to determine the elemental composition of size fractions separated online by FFF

  7. Telecommunication service markets through the year 2000 in relation to millimeter wave satellite systems

    NASA Technical Reports Server (NTRS)

    Stevenson, S. M.

    1979-01-01

    NASA is currently conducting a series of millimeter wave satellite system market studies to develop 30/20 GHz satellite system concepts that have commercial potential. Four contractual efforts were undertaken: two parallel and independent system studies and two parallel and independent market studies. The marketing efforts are focused on forecasting the total domestic demand for long haul telecommunications services for the 1980-2000 period. Work completed to date and reported in this paper include projections of: geographical distribution of traffic; traffic volume as a function of urban area size; and user identification and forecasted demand.

  8. Airborne Fiber Size Characterization in Exposure Estimation: Evaluation of a Modified Transmission Electron Microcopy Protocol for Asbestos and Potential Use for Carbon Nanotubes and Nanofibers

    PubMed Central

    Dement, John M.; Kuempel, Eileen D.; Zumwalde, Ralph D.; Ristich, Anna M.; Fernback, Joseph E.; Smith, Randall J.

    2015-01-01

    Background Airborne fiber size has been shown to be an important factor relative to adverse lung effects of asbestos and suggested in animal studies of carbon nanotubes and nanofibers (CNT/CNF). Materials and Methods The International Standards Organization (ISO) transmission electron microscopy (TEM) method for asbestos was modified to increase the statistical precision of fiber size determinations, improve efficiency, and reduce analysis costs. Comparisons of the fiber size distributions and exposure indices by laboratory and counting method were performed. Results No significant differences in size distributions by the ISO and modified ISO methods were observed. Small but statistically-significant inter-lab differences in the proportion of fibers in some size bins were found, but these differences had little impact on the summary exposure indices. The modified ISO method produced slightly more precise estimates of the long fiber fraction (>15 μm). Conclusions The modified ISO method may be useful for estimating size-specific structure exposures, including CNT/CNF, for risk assessment research. PMID:25675894

  9. Potential Effects of a Scenario Earthquake on the Economy of Southern California: Labor Market Exposure and Sensitivity Analysis to a Magnitude 7.8 Earthquake

    USGS Publications Warehouse

    Sherrouse, Benson C.; Hester, David J.; Wein, Anne M.

    2008-01-01

    The Multi-Hazards Demonstration Project (MHDP) is a collaboration between the U.S. Geological Survey (USGS) and various partners from the public and private sectors and academia, meant to improve Southern California's resiliency to natural hazards (Jones and others, 2007). In support of the MHDP objectives, the ShakeOut Scenario was developed. It describes a magnitude 7.8 (M7.8) earthquake along the southernmost 300 kilometers (200 miles) of the San Andreas Fault, identified by geoscientists as a plausible event that will cause moderate to strong shaking over much of the eight-county (Imperial, Kern, Los Angeles, Orange, Riverside, San Bernardino, San Diego, and Ventura) Southern California region. This report contains an exposure and sensitivity analysis of economic Super Sectors in terms of labor and employment statistics. Exposure is measured as the absolute counts of labor market variables anticipated to experience each level of Instrumental Intensity (a proxy measure of damage). Sensitivity is the percentage of the exposure of each Super Sector to each Instrumental Intensity level. The analysis concerns the direct effect of the scenario earthquake on economic sectors and provides a baseline for the indirect and interactive analysis of an input-output model of the regional economy. The analysis is inspired by the Bureau of Labor Statistics (BLS) report that analyzed the labor market losses (exposure) of a M6.9 earthquake on the Hayward fault by overlaying geocoded labor market data on Instrumental Intensity values. The method used here is influenced by the ZIP-code-level data provided by the California Employment Development Department (CA EDD), which requires the assignment of Instrumental Intensities to ZIP codes. The ZIP-code-level labor market data includes the number of business establishments, employees, and quarterly payroll categorized by the North American Industry Classification System. According to the analysis results, nearly 225,000 business

  10. Preliminary market analysis for Brayton cycle heat recovery system characterization program. Subtask 5. 2 of phase I program plan

    SciTech Connect

    Not Available

    1980-08-31

    The purpose of the task is to determine the market potential of the Brayton-cycle Subatmospheric System (SAS), especially as applied to the glass processing industry. Areas which impact the sales of the Brayton-cycle systems examined are: market size; opportunities for waste heat system installation (furnace rebuild and repair); pollution control on glass furnaces; equipment costs; equipment performance; and market growth potential. Supporting data were compiled for the glass industry inventory and are presented in Appendix A. Emission control techniques in the glass industry are discussed in Appendix B. (MCW)

  11. Marketing new medical devices.

    PubMed

    LoBuglio, R J

    1988-01-01

    cosmetics and beauty aids as his wife. The Germans and the French eat more spaghetti than the Italians. French and Italian housewives are not as interested in cooking as their counterparts in Luxembourg and Belgium. No firm can conduct its business successfully without trying to measure the actual size of markets, present and future. Quantitative measurements are essential for the analysis of market opportunity, the planning of marketing programs, and the control of marketing effort. The firm may make many measures of demand, varying in the level of product aggregation, the time dimension,a nd the space dimension.(ABSTRACT TRUNCATED AT 400 WORDS)

  12. Market trends

    NASA Technical Reports Server (NTRS)

    Fitzsimmons, R. D.

    1976-01-01

    A very large segment of the over water, long haul passenger market, 31% of the passengers who provide 42% of the passenger revenue, offers a significant market for an advanced supersonic transport. This is for both the first class and full-fare economy passenger markets. The supersonic transport may be more competitive here in spite of lower costs of subsonic transports, as passenger preference is a more powerful variable than DOC. This latter fact was amply demonstrated in the late fifties when the jets completely replaced the reciprocating engine transports on most world routes, in spite of slightly higher fares.

  13. Recruiting for Prior Service Market

    DTIC Science & Technology

    2008-06-01

    perceptions, expectations and issues for re-enlistment • Develop potential marketing and advertising tactics and strategies targeted to the defined...01 JUN 2008 2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Recruiting for Prior Service Market 5a. CONTRACT NUMBER 5b. GRANT...Command First Handshake to First Unit of Assignment An Army of One Proud to Be e e to Serve Recruiting for Prior Service Market MAJ Eric Givens / MAJ Brian

  14. Social marketing for public health.

    PubMed

    Walsh, D C; Rudd, R E; Moeykens, B A; Moloney, T W

    1993-01-01

    Marketing techniques and tools, imported from the private sector, are increasingly being advocated for their potential value in crafting and disseminating effective social change strategies. This paper describes the field of social marketing as it is used to improve the health of the public. A disciplined process of strategic planning can yield promising new insights into consumer behavior and product design. But the "technology" cannot simply be transferred without some translation to reconcile differences between commercial marketing and public health.

  15. Essays on competition in electricity markets

    NASA Astrophysics Data System (ADS)

    Bustos Salvagno, Ricardo Javier

    The first chapter shows how technology decisions affect entry in commodity markets with oligopolistic competition, like the electricity market. I demonstrate an entry deterrence effect that works through cost uncertainty. Technology's cost uncertainty affects spot market expected profits through forward market trades. Therefore, incentives to engage in forward trading shape firms' decisions on production technologies. I show that high-cost but low-risk technologies are adopted by risk-averse incumbents to deter entry. Strategic technology adoption can end in a equilibrium where high-cost technologies prevail over low-cost but riskier ones. In the case of incumbents who are less risk-averse than entrants, entry deterrence is achieved by choosing riskier technologies. The main results do not depend on who chooses their technology first. Chapter two examines the Chilean experience on auctions for long-term supply contracts in electricity markets from 2006 to 2011. Using a divisible-good auction model, I provide a theoretical framework that explains bidding behavior in terms of expected spot prices and contracting positions. The model is extended to include potential strategic behavior on contracting decisions. Empirical estimations confirm the main determinants of bidding behavior and show heterogeneity in the marginal cost of over-contracting depending on size and incumbency. Chapter three analyzes the lag in capacity expansion in the Chilean electricity market from 2000 to 2004. Regarded as a result of regulatory uncertainty, the role of delays in the construction of a large hydro-power plant has been overlooked by the literature. We argue that those delays postponed projected investment and gave small windows of opportunity that only incumbents could take advantage of. We are able to retrace the history of investments through real-time information from the regulator's reports and a simple model enables us to explain the effect of those delays on suggested and under

  16. Marketing Reflections.

    ERIC Educational Resources Information Center

    Bush, Gale; Kwielford, Merrilee Andersen

    2001-01-01

    Discusses marketing techniques for teacher librarians based on six levels: basic assumptions; library resource program, including attitudes for success; school, including a collaborative environment; administration, including program support; community, including awareness; and state and national, including professional participation. (LRW)

  17. Emerging energy security issues: Natural gas in the Gulf Nations, An overview of Middle East resources, export potentials, and markets. Report Series No. 4

    SciTech Connect

    Ripple, R.D.; Hagen, R.E.

    1995-09-01

    This paper proceeds with a presentation of the natural gas resource base of the Gulf nations of the Middle East. The resource base is put in the context of the world natural gas resource and trade flows. This is followed by a discussion of the existing and planned project to move Gulf natural gas to consuming regions. Then a discussion of the source of demand in the likely target markets for the Gulf resource follows. Next, the nature of LNG pricing is discussed. A brief summary concludes the paper.

  18. Class Size.

    ERIC Educational Resources Information Center

    Underwood, Siobhan; Lumsden, Linda S.

    1994-01-01

    The items featured in this annotated bibliography touch on several aspects of the multifaceted class-size debate. Allen Odden reviews the literature and contends that class-size reduction should be used "sparingly and strategically." C. M. Achilles and colleagues examines two different class-size situations and find student test…

  19. The Potential of Distance Education and Training for Small and Medium-Sized Enterprises in the Mediterranean Countries of the European Community. A Report for the Commission of the European Communities--Task Force Human Resources, Education, Training, and Youth.

    ERIC Educational Resources Information Center

    Quintino, Luisa

    An evaluation was made of the training needs of the small and medium-sized enterprises (SMEs) in Portugal, Spain, Greece, and Italy and the potential of open, distance, flexible, and multimedia learning to meet those needs. The methodology included contacts with training providers, governmental institutions, and SMEs and circulation of…

  20. Market Assessment of Tuberculosis Diagnostics in Brazil in 2012

    PubMed Central

    2014-01-01

    Background Improved diagnostics for the diagnosis of tuberculosis (TB) are urgently needed. However, test developers and investors require market size data to support new product development. This study assessed the served available market for TB diagnostics in Brazil in 2012 and the market segmentation in the public and private sectors. Methods Data were collected on test volumes done in the public and private sectors for the diagnosis of latent and active TB, drug susceptibility testing and treatment follow-up. Tests included were tuberculin skin tests, interferon-gamma releases assays, smear microscopy, solid and liquid cultures, nucleic acid amplification tests and phenotypic drug susceptibility tests. The data were collected by means of an electronic survey via the Brazilian State laboratories and from sales information provided by manufacturers. Test costs for the public sector were calculated using a components approach, while costs for the private sector were based on prices paid by patients. The overall market value (expenditure) for the entire country was calculated using the public sector test costs. Results During 2012, an estimated total of 2.4 million TB diagnostic tests were done in Brazil, resulting in an estimated overall market value of USD 17.2 million. The public sector accounted for 91% of the test volumes and 88% of the market value. Smear microscopy was the most commonly test (n = 1.3 million; 55% of total) at an estimated value of USD 3.7 million. Culture overall (n = 302,761) represented 13% of test volumes and 40% (USD 6.9 million) of the market value. On average, USD 208 was spent on TB diagnostics for every notified TB patient in Brazil, in 2012. Conclusion The TB diagnostics market value in Brazil in 2012 was over USD 17 million. These study results will help test developers to understand the current and potential market for replacement or add-on diagnostic technologies. PMID:25099237

  1. 42 CFR 423.2268 - Standards for Part D marketing.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Standards for Part D marketing. 423.2268 Section... Marketing Requirements § 423.2268 Standards for Part D marketing. In conducting marketing activities, a Part... Marketing Guidelines) value, are offered to all potential enrollees without regard to whether or not...

  2. Subcellular Size

    PubMed Central

    Marshall, Wallace F.

    2016-01-01

    All of the same conceptual questions about size in organisms apply equally at the level of single cells. What determines the size, not only of the whole cell, but of all its parts? What ensures that subcellular components are properly proportioned relative to the whole cell? How does alteration in organelle size affect biochemical function? Answering such fundamental questions requires us to understand how the size of individual organelles and other cellular structures is determined. Knowledge of organelle biogenesis and dynamics has advanced rapidly in recent years. Does this knowledge give us enough information to formulate reasonable models for organelle size control, or are we still missing something? PMID:25957302

  3. Characterization of influenza virus variants with different sizes of the non-structural (NS) genes and their potential as live influenza vaccine in poultry

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The influenza virus isolate A/turkey/Oregon/71-delNS1 (H7N3) has a 10 nucleotide deletion in the coding region of the NS1 gene and as a result produces a truncated NS1 protein. From a stock of this virus, we found that several variants with different sizes of the NS genes exist. The number of varian...

  4. A marketing strategy for a nursing college.

    PubMed

    Pryde, M; Muller, M

    1995-08-01

    The objective of this study is to explore and describe a marketing strategy for a nursing college. An explorative and descriptive research design, within the context of a nursing college and affiliated hospitals, was followed. A literature study of marketing models was undertaken and the Delphi-method was utilised to determine the contribution of marketing staff and the possible content of a marketing strategy for a nursing college. The results were utilised to describe guidelines for such a strategy, consisting of marketers/marketing agents, target market, product, price, promotional activities, place and market research. Recommendations include the planning, implementation and evaluation of strategy, inservice training for potential marketing agents, inclusion of marketing as part of the formal education of tutors and nurse managers, as well as an impact study of the scholar as the main consumer.

  5. Technical support for the Ohio Clean Coal Technology Program. Volume 2, Baseline of knowledge concerning process modification opportunities, research needs, by-product market potential, and regulatory requirements: Final report

    SciTech Connect

    Olfenbuttel, R.; Clark, S.; Helper, E.; Hinchee, R.; Kuntz, C.; Means, J.; Oxley, J.; Paisley, M.; Rogers, C.; Sheppard, W.; Smolak, L.

    1989-08-28

    This report was prepared for the Ohio Coal Development Office (OCDO) under Grant Agreement No. CDO/R-88-LR1 and comprises two volumes. Volume 1 presents data on the chemical, physical, and leaching characteristics of by-products from a wide variety of clean coal combustion processes. Volume 2 consists of a discussion of (a) process modification waste minimization opportunities and stabilization considerations; (b) research and development needs and issues relating to clean coal combustion technologies and by-products; (c) the market potential for reusing or recycling by-product materials; and (d) regulatory considerations relating to by-product disposal or reuse.

  6. Future direction in airline marketing

    NASA Technical Reports Server (NTRS)

    Colussy, D. A.

    1972-01-01

    The rapid growth and broadening of the air travel market, coupled with a more sophisticated consumer, will dramatically change airline marketing over the next decade. Discussed is the direction this change is likely to take and its implications for companies within the industry. New conceptualization approaches are required if the full potential of this expanding market is to be fully realized. Marketing strategies are developed that will enable various elements of the travel industry to compete not only against each other but also with other products that are competing for the consumer's discretionary income.

  7. Marketing NASA Langley Polymeric Materials

    NASA Technical Reports Server (NTRS)

    Flynn, Diane M.

    1995-01-01

    A marketing tool was created to expand the knowledge of LaRC developed polymeric materials, in order to facilitate the technology transfer process and increase technology commercialization awareness among a non-technical audience. The created brochure features four materials, LaRC-CP, LaRC-RP46, LaRC-SI, and LaRC-IA, and highlights their competitive strengths in potential commercial applications. Excellent opportunities exist in the $40 million per year microelectronics market and the $6 billion adhesives market. It is hoped that the created brochure will generate inquiries regarding the use of the above materials in markets such as these.

  8. Understanding the market for geographic information: A market segmentation and characteristics analysis

    NASA Technical Reports Server (NTRS)

    Piper, William S.; Mick, Mark W.

    1994-01-01

    Findings and results from a marketing research study are presented. The report identifies market segments and the product types to satisfy demand in each. An estimate of market size is based on the specific industries in each segment. A sample of ten industries was used in the study. The scientific study covered U.S. firms only.

  9. The 30/20 GHZ net market assessment

    NASA Technical Reports Server (NTRS)

    Rogers, J. C.; Reiner, P.

    1980-01-01

    By creating a number of market scenarios variations dealing with network types, network sizes, and service price levels were analyzed for their impact on market demand. Each market scenario represents a market demand forecast with results for voice, data, and video service traffic expressed in peak load megabits per second.

  10. Characteristics of trace metals in traffic-derived particles in Hsuehshan Tunnel, Taiwan: size distribution, potential source, and fingerprinting metal ratio

    NASA Astrophysics Data System (ADS)

    Lin, Y.-C.; Tsai, C.-J.; Wu, Y.-C.; Zhang, R.; Chi, K.-H.; Huang, Y.-T.; Lin, S.-H.; Hsu, S.-C.

    2015-04-01

    Traffic emissions are a significant source of airborne particulate matter (PM) in ambient environments. These emissions contain an abundance of toxic metals and thus pose adverse effects on human health. Size-fractionated aerosol samples were collected from May to September 2013 by using micro-orifice uniform deposited impactors (MOUDIs). Sample collection was conducted simultaneously at the inlet and outlet sites of Hsuehshan Tunnel in northern Taiwan, which is the second-longest freeway tunnel (12.9 km) in Asia. This endeavor aims to characterize the chemical constituents and size distributions, as well as fingerprinting ratios of particulate metals emitted by vehicle fleets. A total of 36 metals in size-resolved aerosols were determined through inductively coupled plasma mass spectrometry. Three major groups - namely, tailpipe emissions (Zn, Pb, and V in fine mode), wear debris (Cu, Cd, Fe, Ga, Mn, Mo, Sb, and Sn), and resuspended dust (Ca, Mg, K, and Rb) - of airborne PM metals were categorized on the basis of the results of enrichment factor, correlation matrix, and principal component analysis. Size distributions of wear-originated metals resembled the pattern of crustal elements, which were predominated by super-micron particulates (PM1-10). By contrast, tailpipe exhaust elements such as Zn, Pb, and V were distributed mainly in submicron particles. By employing Cu as a tracer of wear abrasion, several inter-metal ratios - including Fe / Cu (14), Ba / Cu (1.05), Sb / Cu (0.16), Sn / Cu (0.10), and Ga / Cu (0.03) - served as fingerprints for wear debris. However, the data set collected in this work is useful for further studies on traffic emission inventory and human health effects of traffic-related PM.

  11. Creating an effective marketing team. Six leading healthcare marketers offer their perspectives. Interview by Richard D. Stier.

    PubMed

    Bernstein, N D; Dorothy, J; Flexner, W A; Ireland, R C; Newbold, P A; Rice, A

    1989-01-01

    Richard D. Stier, senior vice president and chief marketing officer, Adventist Health System, Shawnee Mission, Kansas, asked six top healthcare marketers to assume they had just been appointed vice president and chief marketing officer for a medium-sized, 300-bed, not-for-profit community hospital. Their mission: Create the most effective, powerhouse marketing team in the country.

  12. Marketing percolation

    NASA Astrophysics Data System (ADS)

    Goldenberg, J.; Libai, B.; Solomon, S.; Jan, N.; Stauffer, D.

    2000-09-01

    A percolation model is presented, with computer simulations for illustrations, to show how the sales of a new product may penetrate the consumer market. We review the traditional approach in the marketing literature, which is based on differential or difference equations similar to the logistic equation (Bass, Manage. Sci. 15 (1969) 215). This mean-field approach is contrasted with the discrete percolation on a lattice, with simulations of "social percolation" (Solomon et al., Physica A 277 (2000) 239) in two to five dimensions giving power laws instead of exponential growth, and strong fluctuations right at the percolation threshold.

  13. Marketing audit in group practice.

    PubMed

    Blackburn, J M

    1984-01-01

    The marketing audit, whether large-scale or small-scale, will soon be critical to the success of every medical group practice. This dynamic process, in which the many components of a group's marketing efforts are analyzed, is examined from the perspective of ideal circumstances and unlimited resources, and more pragmatically, from the perspective of various-sized groups, with different resources and marketing talent. The audit components are prioritized, possible adaptations and combinations are presented, and reasonable implementation mechanisms, designed to address audit outcomes, are suggested.

  14. Assessment of costs and benefits of flexible and alternative fuel use in the U.S. transportation sector. Technical report fourteen: Market potential and impacts of alternative fuel use in light-duty vehicles -- A 2000/2010 analysis

    SciTech Connect

    1996-01-01

    In this report, estimates are provided of the potential, by 2010, to displace conventional light-duty vehicle motor fuels with alternative fuels--compressed natural gas (CNG), liquefied petroleum gas (LPG), methanol from natural gas, ethanol from grain and from cellulosic feedstocks, and electricity--and with replacement fuels such as oxygenates added to gasoline. The 2010 estimates include the motor fuel displacement resulting both from government programs (including the Clean Air Act and EPACT) and from potential market forces. This report also provides an estimate of motor fuel displacement by replacement and alterative fuels in the year 2000. However, in contrast to the 2010 estimates, the year 2000 estimate is restricted to an accounting of the effects of existing programs and regulations. 27 figs., 108 tabs.

  15. Market power and provider consolidation in physician markets.

    PubMed

    Kleiner, Samuel A; White, William D; Lyons, Sean

    2015-03-01

    Physician services comprise a substantial share of total health care spending, and the price of health care services has been cited as a key contributor to the disproportionately high rate of health care spending in the US. However, despite a large literature analyzing market power in the hospital and insurance industries, less is known about the extent to which physicians exercise market power. In this study we make use of a private health insurance claims data set to analyze physician market power for two specialties within three mid-sized US metropolitan areas. Using a method developed for hospital competition analysis, we estimate measures of consumer willingness-to-pay for physician practices within each of these markets and relate these to the prices paid to these practices for a set of physician services. Our results are suggestive of the presence of market power in the markets that we analyze. We simulate physician practice mergers for the two largest practices in each market for each specialty analyzed. Results suggest that practice mergers could result in price increases deemed significant by antitrust authorities in some markets but not in others.

  16. Market assessment of photovoltaic power systems for agricultural applications in Colombia

    NASA Technical Reports Server (NTRS)

    Steigelmann, W.; Neyeloff, S.

    1981-01-01

    The market potential for photovoltaic systems in the agricultural sector of Colombia is assessed. Consideration was given to over twenty specific livestock production, crop production, and rural services applications requiring less than 15 kW of power without backup power. Analysis revealed that near-term potential exists for photovoltaic technology in applications in coffee depulging, cattle watering, rural domestic users, rural water supply and small irrigation, rural telephones, rural health posts, and vaccine refrigeration. Market size would be in the 1200 to 2500 kWp range in the 1981 to 86 timeframe. Positive factors influencing the market size include a lack of electrical services, potential for developing the Llanos Orientales Territory, high fuel costs in remote areas, balance of system availability, the presence of wealthy land owners, and a large government-sponsored contract for photovoltaic (PV)-powered rural telephone systems. The anticipated eligibility of photovoltaic equipment for loans would be a further positive factor in market potential. Important negative factors include relatively inexpensive energy in developed locations, reliance on hydropower, lack of familiarity with PV equipment, a lack of financing, and established foreign competition in PV technology. Recommendations to American PV manufacturers attempting to develop the Colombian market are given.

  17. Market assessment of photovoltaic power systems for agricultural applications in Colombia

    NASA Astrophysics Data System (ADS)

    Steigelmann, W.; Neyeloff, S.

    1981-11-01

    The market potential for photovoltaic systems in the agricultural sector of Colombia is assessed. Consideration was given to over twenty specific livestock production, crop production, and rural services applications requiring less than 15 kW of power without backup power. Analysis revealed that near-term potential exists for photovoltaic technology in applications in coffee depulging, cattle watering, rural domestic users, rural water supply and small irrigation, rural telephones, rural health posts, and vaccine refrigeration. Market size would be in the 1200 to 2500 kWp range in the 1981 to 86 timeframe. Positive factors influencing the market size include a lack of electrical services, potential for developing the Llanos Orientales Territory, high fuel costs in remote areas, balance of system availability, the presence of wealthy land owners, and a large government-sponsored contract for photovoltaic (PV)-powered rural telephone systems. The anticipated eligibility of photovoltaic equipment for loans would be a further positive factor in market potential. Important negative factors include relatively inexpensive energy in developed locations, reliance on hydropower, lack of familiarity with PV equipment, a lack of financing, and established foreign competition in PV technology. Recommendations to American PV manufacturers attempting to develop the Colombian market are given.

  18. Small sizes and indolent evolutionary dynamics challenge the potential role of P2RY8-CRLF2-harboring clones as main relapse-driving force in childhood ALL.

    PubMed

    Morak, Maria; Attarbaschi, Andishe; Fischer, Susanna; Nassimbeni, Christine; Grausenburger, Reinhard; Bastelberger, Stephan; Krentz, Stefanie; Cario, Gunnar; Kasper, David; Schmitt, Klaus; Russell, Lisa J; Pötschger, Ulrike; Stanulla, Martin; Eckert, Conny; Mann, Georg; Haas, Oskar A; Panzer-Grümayer, Renate

    2012-12-20

    The P2RY8-CRLF2 fusion defines a particular relapse-prone subset of childhood acute lymphoblastic leukemia (ALL) in Italian Association of Pediatric Hematology and Oncology Berlin-Frankfurt-Münster (AIEOP-BFM) 2000 protocols. To investigate whether and to what extent different clone sizes influence disease and relapse development, we quantified the genomic P2RY8-CRLF2 fusion product and correlated it with the corresponding CRLF2 expression levels in patients enrolled in the BFM-ALL 2000 protocol in Austria. Of 268 cases without recurrent chromosomal translocations and high hyperdiploidy, representing approximately 50% of all cases, 67 (25%) were P2RY8-CRLF2 positive. The respective clone sizes were ≥ 20% in 27% and < 20% in 73% of them. The cumulative incidence of relapse of the entire fusion-positive group was clone size independent and significantly higher than that of the fusion-negative group (35% ± 8% vs 13% ± 3%, P = .008) and primarily confined to the non-high-risk group. Of 22 P2RY8-CRLF2-positive diagnosis/relapse pairs, only 4/8 had the fusion-positive dominant clone conserved at relapse, whereas none of the original 14 fusion-positive small clones reappeared as the dominant relapse clone. We conclude that the majority of P2RY8-CRLF2-positive clones are small at diagnosis and virtually never generate a dominant relapse clone. Our findings therefore suggest that P2RY8-CRLF2-positive clones do not have the necessary proliferative or selective advantage to evolve into a disease-relevant relapse clone.

  19. Market study: 3-D eyetracker

    NASA Technical Reports Server (NTRS)

    1977-01-01

    A market study of a proposed version of a 3-D eyetracker for initial use at NASA's Ames Research Center was made. The commercialization potential of a simplified, less expensive 3-D eyetracker was ascertained. Primary focus on present and potential users of eyetrackers, as well as present and potential manufacturers has provided an effective means of analyzing the prospects for commercialization.

  20. Compressed television transmission: A market survey

    NASA Technical Reports Server (NTRS)

    Lizak, R. M.; Cagan, L. Q.

    1981-01-01

    NASA's compressed television transmission technology is described, and its potential market is considered; a market that encompasses teleconferencing, remote medical diagnosis, patient monitoring, transit station surveillance, as well as traffic management and control. In addition, current and potential television transmission systems and their costs and potential manufacturers are considered.

  1. 48 CFR 570.301 - Market survey.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Market survey. 570.301 Section 570.301 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION SPECIAL CONTRACTING... Real Property 570.301 Market survey. Conduct a market survey to identify potential sources....

  2. Student Target Marketing Strategies for Universities

    ERIC Educational Resources Information Center

    Lewison, Dale M.; Hawes, Jon M.

    2007-01-01

    As colleges and universities adopt marketing orientations to an ever-increasing extent, the relative merits of mass marketing and target marketing must also be explored. Researchers identify buyer types as potential students focused on quality, value or economy. On the other axis, learner types are described as those who focus on career,…

  3. Sports Marketing.

    ERIC Educational Resources Information Center

    Ohio State Dept. of Education, Columbus. Div. of Career-Technical and Adult Education.

    This document presents the Ohio Integrated Technical and Academic Competency profile for sports marketing. The profile is to serve as the basis for curriculum development in Ohio's secondary, adult, and postsecondary programs. The profile includes a comprehensive listing of 999 specialty key indicators for evaluating mastery of 113 competencies in…

  4. Physicochemical properties of hull-less barley fibre-rich fractions varying in particle size and their potential as functional ingredients in two-layer flat bread.

    PubMed

    Izydorczyk, M S; Chornick, T L; Paulley, F G; Edwards, N M; Dexter, J E

    2008-05-15

    The performance of barley fibre-rich fractions (FRF), as high dietary fibre ingredients, in two-layer flat bread was investigated. In addition, the effects of particle size reduction by pin milling on functional properties of FRF were studied. FRF enriched in non-starch polysaccharides (β-glucans and arabinoxylans) were obtained by roller milling of hull-less barley. Pin milling (PM) of FRF significantly reduced their particle size, slightly increased the solubility of β-glucans and arabinoxylans, and increased the viscosity of water slurries containing FRF. The addition of 20% of barley FRF to wheat flour significantly increased dough water absorption and weakened the dough properties, as indicated by farinograph mixing curves, but the FRF-enriched doughs exhibited good handling characteristics at the dividing and sheeting stages. The appearance, diameter, layer separation, crumb, and aroma of the FRF-enriched flat breads were comparable to that of the control. The PM of FRF did not significantly affect the dough handling or the quality characteristics of flat breads. The addition of 20% of barley FRF to wheat flour flat bread provided substantial health benefits by significantly increasing the total and soluble dietary fibre contents and by decreasing starch digestibility.

  5. Marketing Reference Services.

    ERIC Educational Resources Information Center

    Norman, O. Gene

    1995-01-01

    Relates the marketing concept to library reference services. Highlights include a review of the literature and an overview of marketing, including research, the marketing mix, strategic plan, marketing plan, and marketing audit. Marketing principles are applied to reference services through the marketing mix elements of product, price, place, and…

  6. Economics and regulation of petroleum futures markets

    SciTech Connect

    Not Available

    1980-08-01

    Because the futures market in petroleum products is a relatively recent phenomenon, the implications of public policies formulated for that market have not yet been fully explored. To provide the Office of Competition of the Department of Energy (DOE) with sufficient information to assess policy alternatives, Resource Planning Associates, Inc. (RPA) was asked to analyze the development of the futures market in No. 2 oil, assess the potential for futures markets in other petroleum products, and identify policy alternatives available to DOE. To perform this analysis, the criteria for a viable futures market was established first. Then, the experience to date with the 18-month-old futures market in No. 2 oil was examined, and the potential for viable futures markets in No. 6 oil, gasoline, jet fuel, and crude oil was assessed. Finally, how existing DOE regulations and prospective actions might affect petroleum futures market development was investigated.

  7. EVALUATION OF OPTICALLY ACQUIRED ZOOPLANKTON SIZE-SPECTRUM DATA AS A POTENTIAL TOOL FOR ASSESSMENT OF CONDITION IN THE GREAT LAKES

    EPA Science Inventory

    An optical zooplankton counter (OPC) potentially provides as assessment tool for zooplankton condition in ecosystems that is rapid, economical, and spatially extensive. We collected zooplankton data with an optical zooplankton counter in 20 near-shore regions of four of the Laure...

  8. Prospects for the medium- and long-term development of China`s electric power industry and analysis of the potential market for superconductivity technology

    SciTech Connect

    Li, Z.

    1998-05-01

    First of all, overall economic growth objectives in China are concisely and succinctly specified in this report. Secondly, this report presents a forecast of energy supply and demand for China`s economic growth for 2000--2050. In comparison with the capability of energy construction in China in the future, a gap between supply and demand is one of the important factors hindering the sustainable development of Chain`s economy. The electric power industry is one of China`s most important industries. To adopt energy efficiency through high technology and utilizing energy adequately is an important technological policy for the development of China`s electric power industry in the future. After briefly describing the achievements of China`s electric power industry, this report defines the target areas and policies for the development of hydroelectricity and nuclear electricity in the 2000s in China, presents the strategic position of China`s electric power industry as well as objectives and relevant plans of development for 2000--2050. This report finds that with the discovery of superconducting electricity, the discovery of new high-temperature superconducting (HTS) materials, and progress in materials techniques, the 21st century will be an era of superconductivity. Applications of superconductivity in the energy field, such as superconducting storage, superconducting transmission, superconducting transformers, superconducting motors, its application in Magneto-Hydro-Dynamics (MHD), as well as in nuclear fusion, has unique advantages. Its market prospects are quite promising. 12 figs.

  9. Markets for hospital services in Zambia.

    PubMed

    Nakamba, Pamela; Hanson, Kara; McPake, Barbara

    2002-01-01

    Hospital reforms involving the introduction of measures to increase competition in hospital markets are being implemented in a range of low and middle-income countries. However, little is understood about the operation of hospital markets outside the USA and the UK. This paper assesses the degree of competition for hospital services in two hospital markets in Zambia (Copperbelt and Midlands), and the implications for prices, quality and efficiency. We found substantial differences among different hospital types in prices, costs and quality, suggesting that the hospital service market is a segmented market. The two markets differ significantly in their degree of competition, with the high cost inpatient services market in Copperbelt relatively more competitive than that in the Midlands market. The implications of these differences are discussed in terms of the potential for competition to improve hospital performance, the impact of market structure on equity of access, and how the government should address the problem of the mine hospitals.

  10. Requirements and Markets for Nanoelectronics

    NASA Astrophysics Data System (ADS)

    Hoefflinger, Bernd

    The semiconductor market grew 2010 by 70Bio. against 2009, more than in the previous 9 years taken together, and the semiconductor industry launched the biggest investment program in its history with 100Bio. over a 2-year period. This was the overture to a decade with great potential and great challenges. We look at the market segments and the required electronic functions, and we highlight four product and service areas: Approaching 6 Billion mobile-phone subscribers Access to education for any child One Carebot (personal robot) per family Efficient and safe personal mobility. At the level of over four billion active mobile phones 2010, it is clear that mobile electronic companions have become the drivers of nanoelectronic innovations with growth only limited by the creation and support of new, attractive features and services. Energy, bandwidth, size and weight requirements of these consumer products provide the largest pressure for System-on-Chip (SoC) architectures. Other exemplary new products are selected for their significance, some for their lengthy path into the market. Health care is such an example: The non-invasive glucose sensor and the portable ECG recorder" with automatic, neuroprocessor-driven event detection in the size of a quarter would serve hundreds of millions of people. Nanoelectronics for self-guided health is an area of public policy in view of the cost of "a posteriori" medical care. Access to information and education for any child/student will be provided by 1 tablets where service contracts and the spin-offs from surfing and cloud-computing will generate the revenue. Personal robots, coined by the ageing Japanese nation as the key product after the PC and ridiculed by others, will arrive as carebots for education, entertainment, rehabilitation, and home-service, accepted as a large-scale need by 2020 in most developed countries including China. Accident prevention systems on rail and road already would make millions of units per year

  11. Future market for ceramics in vehicle engines and their impacts

    SciTech Connect

    Vyas, A.; Hanson, D.; Stodolsky, F. |

    1995-02-01

    Ceramic engine components have potential to improve vehicle fuel economy. Some recent tests have also shown their environmental benefits, particularly in reducing particulate emissions in heavy-duty diesel engines. The authors used the data from a survey of the US vehicle engine and component manufacturers relating to ceramic engine components to develop a set of market penetration models. The survey identified promising ceramic components and provided data on the timing of achieving introductory shares in light and heavy-duty markets. Some ceramic components will penetrate the market when the pilot-scale costs are reduced to one-fifth of their current values, and many more will enter the market when the costs are reduced to one-tenth of the current values. An ongoing ceramics research program sponsored by the US Department of Energy has the goal of achieving such price reductions. The size and value of the future ceramic components market and the impacts of this market in terms of fuel savings, reduction in carbon dioxide emissions, and potential reduction in other criteria pollutants are presented. The future ceramic components market will be 9 million components worth $29 million within 5 years of introduction and will expand to 692 million components worth $3,484 million within 20 years. The projected annual energy savings are 3.8 trillion Btu by 5 years, increasing to 526 trillion Btu during the twentieth year. These energy savings will reduce carbon dioxide emissions by 41 million tons during the twentieth year. Ceramic components will help reduce particulate emissions by 100 million tons in 2030 and save the nation`s urban areas $152 million. The paper presents the analytical approach and discusses other economic impacts.

  12. Marketing and population problems.

    PubMed

    Farley, J U; Leavitt, H J

    1971-07-01

    There are many elements in population programs that are more familiar to marketing men than to some population experts. Advertising is essential to reach the target population, and advertising evaluation techniques (e.g., surrogate indexes or audience measures) might be useful for evaluating both population information activities and the import of the entire program. Fundamental research on basid demand for fertility control is needed and a marketer's experience with planning and evaluating test markets can be useful in assessing potential selling targets and evaluating alternative promotional and distributional strategies. Special family planning clinics have certain disadvantages: expensive and scarce personnel are needed; red tape may be present; the network is based on the assumption that the client is willing to travel relatively great distances repeatedly; and clinics lack anonymity which may scare potential acceptors away. Most developing cultures have an intensively functioning distribution structure which delivers basic commodities to the most remote areas, providing relatively anonymous outlets that are physically close to the customs. Materials requiring a prescription might be distributed in exchange for script issued at and ultimately redeemed by clinics, this requiring only an occasional visit to a clinic. Mail-order service can be used to supplement a clinic's distribution of some contraceptives. It should be remembered that population administrators often have an antipathetic view toward business and marketing and "suspect" the profit motive.

  13. Polarized spectral properties and potential application of large-size Nd3+:Ba3Gd2(BO3)4 crystal

    NASA Astrophysics Data System (ADS)

    Gao, S. F.; Lv, S. Z.; Zhu, Z. J.; Wang, Y.; You, Z. Y.; Li, J. F.; Xu, J. L.; Wang, H. Y.; Tu, C. Y.

    2014-06-01

    The Nd3+-doped Ba3Gd2(BO3)4 crystal with high optical quality and large size is reported in this paper. The growing processes and characteristics of Nd3+:Ba3Gd2(BO3)4 crystal are discussed. The absorption and luminescence spectra of Nd3+ in Ba3Gd2(BO3)4 crystal were measured at room temperature. The luminescence decay curve in correspondence with the 4F3/2 →4I11/2 transition centered at 1062 nm was also measured. The JO intensity parameters Ωt (t = 2,4,6) were calculated to be Ω2 = 1.263, Ω4 = 2.496, Ω6 = 3.606. The radiative lifetime τr and fluorescence lifetime τf are 317.771 and 115 μs respectively, and the fluorescence quantum efficiency is 37.1%.

  14. Marketing organ donation around the globe.

    PubMed

    Guy, B S; Aldridge, A

    2001-01-01

    Marketing to potential organ donors in different countries requires knowledge about religious beliefs and cultural norms that might influence the decision to donate. Because beliefs vary so widely from country to country, marketers need to consider whether a standardized or adaptive approach is suitable for marketing organ donation in different countries. This article takes a look at the variables that influence the decision to donate an organ and suggests marketing strategies that may work in various parts of the world.

  15. Variation in the Oral Processing of Everyday Meals Is Associated with Fullness and Meal Size; A Potential Nudge to Reduce Energy Intake?

    PubMed Central

    Ferriday, Danielle; Bosworth, Matthew L.; Godinot, Nicolas; Martin, Nathalie; Forde, Ciarán G.; Van Den Heuvel, Emmy; Appleton, Sarah L.; Mercer Moss, Felix J.; Rogers, Peter J.; Brunstrom, Jeffrey M.

    2016-01-01

    Laboratory studies have demonstrated that experimental manipulations of oral processing can have a marked effect on energy intake. Here, we explored whether variations in oral processing across a range of unmodified everyday meals could affect post-meal fullness and meal size. In Study 1, female participants (N = 12) attended the laboratory over 20 lunchtime sessions to consume a 400-kcal portion of a different commercially available pre-packaged meal. Prior to consumption, expected satiation was assessed. During each meal, oral processing was characterised using: (i) video-recordings of the mouth and (ii) real-time measures of plate weight. Hunger and fullness ratings were elicited pre- and post-consumption, and for a further three hours. Foods that were eaten slowly had higher expected satiation and delivered more satiation and satiety. Building on these findings, in Study 2 we selected two meals (identical energy density) from Study 1 that were equally liked but maximised differences in oral processing. On separate days, male and female participants (N = 24) consumed a 400-kcal portion of either the “fast” or “slow” meal followed by an ad libitum meal (either the same food or a dessert). When continuing with the same food, participants consumed less of the slow meal. Further, differences in food intake during the ad libitum meal were not compensated at a subsequent snacking opportunity an hour later. Together, these findings suggest that variations in oral processing across a range of unmodified everyday meals can affect fullness after consuming a fixed portion and can also impact meal size. Modifying food form to encourage increased oral processing (albeit to a lesser extent than in experimental manipulations) might represent a viable target for food manufacturers to help to nudge consumers to manage their weight. PMID:27213451

  16. Characteristics of pebble and cobble-sized clasts along the Curiosity rover traverse from sol 100 to 750: Terrain types, potential sources, and transport mechanisms

    NASA Astrophysics Data System (ADS)

    Yingst, R. A.; Cropper, K.; Gupta, S.; Kah, L. C.; Williams, R. M. E.; Blank, J.; Calef, F.; Hamilton, V. E.; Lewis, K.; Shechet, J.; McBride, M.; Bridges, N.; Frias, J. Martinez; Newsom, H.

    2016-12-01

    We combine the results of orbitally-derived morphologic and thermal inertia data with in situ observations of abundance, size, morphologic characteristics, and distribution of pebble- to cobble-sized clasts along the Curiosity rover traverse. Our goals are to characterize rock sources and transport history, and improve our ability to predict upcoming terrain. There are ten clast types, with nine types interpreted as sedimentary rocks. Only Type 3 clasts had morphologies indicative of significant wear through transport; thus, most clast types are indicative of nearby outcrops or prior presence of laterally extensive sedimentary rock layers, consistent with the erosional landscape. A minor component may reflect impact delivery of more distant material. Types 1 and 4 are heavily-cemented sandstones, likely associated with a "caprock" layer. Types 5 and 6 (and possibly 7) are pebble-rich sandstones, with varying amounts of cement leading to varying susceptibility to erosion/wear. Type 3 clasts are rounded pebbles likely transported and deposited alluvially, then worn out of pebbly sandstone/conglomerate. Types 9 and 10 are poorly-sorted sandstones, with Type 9 representing fragments of Square Top-type layers, and Type 10 deriving from basal or other Mt. Sharp layers. Types 2, 8 and 9 are considered exotics. There are few clear links between clast type and terrain surface roughness (particularly in identifying terrain that is challenging for the rover to navigate). Orbital data may provide a reasonable prediction of certain end-member terrains but the complex interplay between variables that contribute to surface characteristics makes discriminating between terrain types from orbital data problematic. Prediction would likely be improved through higher-resolution thermal inertia data.

  17. How healthcare organizations use the Internet to market quality achievements.

    PubMed

    Revere, Lee; Robinson, Leroy

    2010-01-01

    The increasingly competitive environment is having a strong bearing on the strategic marketing practices of hospitals. The Internet is a fairly new marketing tool, and it has the potential to dramatically influence healthcare consumers. This exploratory study investigates how hospitals use the Internet as a tool to market the quality of their services. Significant evidence exists that customers use the Internet to find information about potential healthcare providers, including information concerning quality. Data were collected from a random sample of 45 U.S. hospitals from the American Hospital Association database. The data included hospital affiliation, number of staffed beds, accreditation status, Joint Commission quality awards, and number of competing hospitals. The study's findings show that system-affiliated hospitals do not provide more, or less, quality information on their websites than do non-system-affiliated hospitals. The findings suggest that the amount of quality information provided on a hospital website is not dependent on hospital size. Research provides evidence that hospitals with more Joint Commission awards promote their quality accomplishments more so than their counterparts that earned fewer Joint Commission awards. The findings also suggest that the more competitors in a marketplace the more likely a hospital is to promote its quality as a potential differential advantage. The study's findings indicate that a necessary element of any hospital's competitive strategy should be to include the marketing of its quality on the organization's website.

  18. Customer premises services market demand assessment 1980 - 2000: Volume 2

    NASA Technical Reports Server (NTRS)

    Gamble, R. B.; Saporta, L.; Heidenrich, G. A.

    1983-01-01

    Potential customer premises service (CPS), telecommunication services, potential CPS user classes, a primary research survey, comparative economics, market demand forcasts, distance distribution of traffic, segmentation of market demand, and a nationwide traffic distribution model are discussed.

  19. Defense display market assessment

    NASA Astrophysics Data System (ADS)

    Desjardins, Daniel D.; Hopper, Darrel G.

    1998-09-01

    This paper addresses the number, function and size of principal military displays and establishes a basis to determine the opportunities for technology insertion in the immediate future and into the next millennium. Principal military displays are defined as those occupying appreciable crewstation real-estate and/or those without which the platform could not carry out its intended mission. DoD 'office' applications are excluded from this study. The military displays market is specified by such parameters as active area and footprint size, and other characteristics such as luminance, gray scale, resolution, angle, color, video capability, and night vision imaging system (NVIS) compatibility. Funded, future acquisitions, planned and predicted crewstation modification kits, and form-fit upgrades are taken into account. This paper provides an overview of the DoD niche market, allowing both government and industry a necessary reference by which to meet DoD requirements for military displays in a timely and cost-effective manner. The aggregate DoD market for direct-view and large-area military displays is presently estimated to be in excess of 242,000. Miniature displays are those which must be magnified to be viewed, involve a significantly different manufacturing paradigm and are used in helmet mounted displays and thermal weapon sight applications. Some 114,000 miniature displays are presently included within Service weapon system acquisition plans. For vendor production planning purposes it is noted that foreign military sales could substantially increase these quantities. The vanishing vendor syndrome (VVS) for older display technologies continues to be a growing, pervasive problem throughout DoD, which consequently must leverage the more modern display technologies being developed for civil- commercial markets.

  20. A conceptual investigation of variables affecting the success and acceptance of SMS Marketing in Iran.

    PubMed

    Adhami, A; Rabiee, A; Adhami, M

    2015-01-01

    This paper's aim was to develop a conceptual overview of SMS marketing and delineate factors of new communications technologies on business practice. This study, which was a descriptive survey, was built on primary and secondary data source including a literature review of SMS marketing and a Questionnaire were used as the primary means of collecting secondary data. The sample size of 300 patients was determined according to the Cochran formula. Moreover, data analysis was done in SPSS by using linear regression, chi-square, t-test and Binomial test. According to the research, sex, age, education, relevance, timeliness, reliability to sender, sense of control were variables affecting the SMS marketing acceptance. This paper was qualitative and provided a solid conceptual foundation for the future empirical research on e- marketing. The potential limitation was related to the broad user of computer and mobile. In this research, we considered SMS marketing, Mobile marketing, SMS advertising as the same subject. This research will be a useful resource with important insight into the factors that may encourage or determine consumer acceptance of this new form of direct marketing. This paper addressed an important timely issue, and added to the body of literature and knowledge focusing on e-marketing.

  1. A conceptual investigation of variables affecting the success and acceptance of SMS Marketing in Iran

    PubMed Central

    Adhami, A; Rabiee, A; Adhami, M

    2015-01-01

    This paper’s aim was to develop a conceptual overview of SMS marketing and delineate factors of new communications technologies on business practice. This study, which was a descriptive survey, was built on primary and secondary data source including a literature review of SMS marketing and a Questionnaire were used as the primary means of collecting secondary data. The sample size of 300 patients was determined according to the Cochran formula. Moreover, data analysis was done in SPSS by using linear regression, chi-square, t-test and Binomial test. According to the research, sex, age, education, relevance, timeliness, reliability to sender, sense of control were variables affecting the SMS marketing acceptance. This paper was qualitative and provided a solid conceptual foundation for the future empirical research on e- marketing. The potential limitation was related to the broad user of computer and mobile. In this research, we considered SMS marketing, Mobile marketing, SMS advertising as the same subject. This research will be a useful resource with important insight into the factors that may encourage or determine consumer acceptance of this new form of direct marketing. This paper addressed an important timely issue, and added to the body of literature and knowledge focusing on e-marketing. PMID:28255405

  2. View on world market

    SciTech Connect

    Poulsen, J.

    1996-12-31

    Opinions on the world market for wind power are presented in this paper. Reasons contributing to a potential growth in wind power are cited. Increased demand is expected to arise due to increased energy needs and environmental concerns. Barriers, primarily political, to the development of wind energy are assessed. Development is predicted to occur first in countries with a demand for new capacity and political decisions to protect the environment.

  3. Biotechnological applications and prospective market of microbial keratinases.

    PubMed

    Gupta, Rani; Rajput, Rinky; Sharma, Richa; Gupta, Namita

    2013-12-01

    Keratinases are well-recognized enzymes with the unique ability to attack highly cross-linked, recalcitrant structural proteins such as keratin. Their potential in environmental clean-up of huge amount of feather waste has been well established since long. Today, they have gained importance in various other biotechnological and pharmaceutical applications. However, commercial availability of keratinases is still limited. Hence, to attract entrepreneurs, investors and enzyme industries it is utmost important to explicitly present the market potential of keratinases through detailed account of its application sectors. Here, the application areas have been divided into three parts: the first one is dealing with the area of exclusive applications, the second emphasizes protease dominated sectors where keratinases would prove better substitutes, and the third deals with upcoming newer areas which still await practical documentation. An account of benefits of keratinase usage, existing market size, and available commercial sources and products has also been presented.

  4. Potential of Securitization in Solar PV Finance

    SciTech Connect

    Lowder, T.; Mendelsohn, M.

    2013-12-01

    This report aims to demonstrate, hypothetically and at a high level, what volumes of solar deployment could be supported given solar industry access to the capital markets in the form of security issuance. Securitization is not anticipated to replace tax equity in the near- to mid-term, but it could provide an additional source of funds that would be comparatively inexpensive and could reduce the weighted average cost of capital for a given solar project or portfolio. Thus, the potential to securitize solar assets and seek financing in the capital markets could help to sustain the solar industry when the investment tax credit (ITC) -- one of the federal incentives that has leveraged billions of dollars of private capital in the solar industry -- drops from 30% to 10% at the close of 2016. The report offers analysis on the size of the U.S. third-party financed solar market, as well as on the volumes (in MW) of solar asset origination possible through a $100 million securitization fund (assuming no overcollateralization). It also provides data on the size of the relevant securities markets and how the solar asset class may fit into these markets.

  5. Civil markets for buoyant heavy-lift vehicles

    NASA Technical Reports Server (NTRS)

    Mettam, P. J.; Hansen, D.; Ardema, M. D.

    1981-01-01

    Worldwide civil markets for heavy lift airships were investigated. Substantial potential market demand was identified for payloads of from 13 to 800 tons. The largest markets appear to be in applications to relieve port congestion, construction of power generating plants, and, most notably, logging. Because of significant uncertainties both in vehicle and market characteristics, further analysis will be necessary to verify the identified market potential of heavy lift airship concepts.

  6. Market efficiency in foreign exchange markets

    NASA Astrophysics Data System (ADS)

    Oh, Gabjin; Kim, Seunghwan; Eom, Cheoljun

    2007-08-01

    We investigate the relative market efficiency in financial market data, using the approximate entropy(ApEn) method for a quantification of randomness in time series. We used the global foreign exchange market indices for 17 countries during two periods from 1984 to 1998 and from 1999 to 2004 in order to study the efficiency of various foreign exchange markets around the market crisis. We found that on average, the ApEn values for European and North American foreign exchange markets are larger than those for African and Asian ones except Japan. We also found that the ApEn for Asian markets increased significantly after the Asian currency crisis. Our results suggest that the markets with a larger liquidity such as European and North American foreign exchange markets have a higher market efficiency than those with a smaller liquidity such as the African and Asian markets except Japan.

  7. Does the market maker stabilize the market?

    NASA Astrophysics Data System (ADS)

    Zhu, Mei; Chiarella, Carl; He, Xue-Zhong; Wang, Duo

    2009-08-01

    The market maker plays an important role in price formation, but his/her behavior and stabilizing impact on the market are relatively unclear, in particular in speculative markets. This paper develops a financial market model that examines the impact on market stability of the market maker, who acts as both a liquidity provider and an active investor in a market consisting of two types of boundedly rational speculative investors-the fundamentalists and trend followers. We show that the market maker does not necessarily stabilize the market when he/she actively manages the inventory to maximize profits, and that rather the market maker’s impact depends on the behavior of the speculators. Numerical simulations show that the model is able to generate outcomes for asset returns and market inventories that are consistent with empirical findings.

  8. Little study sees large growth in Asian natural gas market

    SciTech Connect

    O'Driscoll, M.

    1993-06-03

    Power capacity additions in Asia will at least triple by 2010, and Arthur D. Little Inc. predicts natural gas can pick up a good 15 percent of that market. The study predicts Asia potentially will need 720 gigawatts of new power generation by 2010, of which 15 percent may be gas-based. This represents a market three times the size of the US market in the same period, and would require more than $1 trillion in investment to finance the power generation projects alone. Six forces are driving new market opportunities for natural gas in Asia, and have set the stage for major investments in Asian gas-based power generation. They are: New technologies; growing environmental pressures; privatization; alternative energy pricing; gas availability; and continued economic growth. Japan, South Korea and Taiwan already have large, well-established markets for both gas and power that provide minimal opportunities for foreign investment. But the rest of Asia - specifically, India, Pakistan, the Philippines, Vietnam, Indonesia, Malaysia, the People's Republic of China, Thailand, Bangladesh and Myanmar - is still relatively undeveloped, the study said, and gas is emerging as an energy import substitute or export earner. The study found those countries will turn increased environmental awareness and concern into legislation as their economic prosperity grows, leading to a higher future value for natural gas relative to other fuels. Stricter emissions standards will favor gas over diesel, fuel oil and coal.

  9. 7 CFR 987.12 - Marketable dates.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... pursuant to § 987.40. Marketable dates shall include but not be limited to the following: (a) DAC dates. DAC dates are marketable whole or pitted dates that are inspected and certified as meeting the grade... handler that are certified as meeting the same grade and size requirements for DAC dates, with...

  10. Alternative Fuels Market and Policy Trends (Presentation)

    SciTech Connect

    Schroeder, A. N.

    2013-09-01

    Market forces and policies are increasing opportunities for alternative fuels. There is no one-size-fits-all, catch-all, silver-bullet fuel. States play a critical role in the alternative fuel market and are taking a leading role.

  11. Initial comparisons of modular-sized, integrated utility systems and conventional systems for several building types

    NASA Technical Reports Server (NTRS)

    Benson, H. E.; Monford, L. G., Jr.

    1976-01-01

    The results of a study of the application of a modular integrated utility system to six typical building types are compared with the application of a conventional utility system to the same facilities. The effects of varying the size and climatic location of the buildings and the size of the powerplants are presented. Construction details of the six building types (garden apartments, a high rise office building, high rise apartments, a shopping center, a high school, and a hospital) and typical site and floor plans are provided. The environmental effects, the unit size determination, and the market potential are discussed. The cost effectiveness of the various design options is not considered.

  12. Cell-Size Control

    PubMed Central

    Amodeo, Amanda A.; Skotheim, Jan M.

    2015-01-01

    Cells of a given type maintain a characteristic cell size to function efficiently in their ecological or organismal context. They achieve this through the regulation of growth rates or by actively sensing size and coupling this signal to cell division. We focus this review on potential size-sensing mechanisms, including geometric, external cue, and titration mechanisms. Mechanisms that titrate proteins against DNA are of particular interest because they are consistent with the robust correlation of DNA content and cell size. We review the literature, which suggests that titration mechanisms may underlie cell-size sensing in Xenopus embryos, budding yeast, and Escherichia coli, whereas alternative mechanisms may function in fission yeast. PMID:26254313

  13. Exploring Size.

    ERIC Educational Resources Information Center

    Brand, Judith, Ed.

    1995-01-01

    "Exploring" is a magazine of science, art, and human perception that communicates ideas museum exhibits cannot demonstrate easily by using experiments and activities for the classroom. This issue concentrates on size, examining it from a variety of viewpoints. The focus allows students to investigate and discuss interconnections among…

  14. Marketing Maps: Illustrating How Marketing Works

    ERIC Educational Resources Information Center

    Gyure, James F.; Arnold, Susan G.

    2003-01-01

    Today's colleges and universities may tolerate the "idea" of marketing more easily, but marketers must continue to educate campus communities about marketing theories and practice. To promote a useful appreciation of how theories translate into initiatives, we propose incorporating "marketing maps"-user-friendly graphic representations of how…

  15. Potential impact of species and livestock density on the epidemic size and effectiveness of control measures for foot-and-mouth disease in Japan

    PubMed Central

    HAYAMA, Yoko; YAMAMOTO, Takehisa; KOBAYASHI, Sota; MUROGA, Norihiko; TSUTSUI, Toshiyuki

    2015-01-01

    The characteristics of a livestock area, including farm density and animal species, influence the spread of foot-and-mouth disease (FMD). In this study, the impact of livestock area on FMD epidemics was examined using an FMD transmission model. For this simulation, three major livestock areas were selected: the 2010 FMD epidemic area in Japan as the baseline area (BS), a cattle and pig mixed production area (CP) and a cattle production area (C). Simulation results demonstrated that under the 24-hr culling policy, only 12% of epidemics among 1,000 simulations were abated within 100 days in the CP area, whereas 90% of the epidemics ceased in the BS area. In the C area, all epidemics were successfully contained within 100 days. Evaluation of additional control measures in the CP area showed that the 0.5-km pre-emptive culling, even when only targeting pig farms, raised the potential for successful containment to 94%. A 10-km vaccination on day 7 or 14 after initial detection was also effective in halting the epidemics (80%), but accompanied a large number of culled or vaccinated farms. The combined strategy of 10-km vaccination and 0.5-km pre-emptive culling targeting pig farms succeeded in containing all epidemics within 100 days. The present study suggests the importance of preparedness for the 24-hr culling policy and additional control measures when an FMD outbreak occurs in a densely populated area. Considering the characteristics of the livestock area is important in planning FMD control strategies. PMID:26256043

  16. Potential impact of species and livestock density on the epidemic size and effectiveness of control measures for foot-and-mouth disease in Japan.

    PubMed

    Hayama, Yoko; Yamamoto, Takehisa; Kobayashi, Sota; Muroga, Norihiko; Tsutsui, Toshiyuki

    2016-01-01

    The characteristics of a livestock area, including farm density and animal species, influence the spread of foot-and-mouth disease (FMD). In this study, the impact of livestock area on FMD epidemics was examined using an FMD transmission model. For this simulation, three major livestock areas were selected: the 2010 FMD epidemic area in Japan as the baseline area (BS), a cattle and pig mixed production area (CP) and a cattle production area (C). Simulation results demonstrated that under the 24-hr culling policy, only 12% of epidemics among 1,000 simulations were abated within 100 days in the CP area, whereas 90% of the epidemics ceased in the BS area. In the C area, all epidemics were successfully contained within 100 days. Evaluation of additional control measures in the CP area showed that the 0.5-km pre-emptive culling, even when only targeting pig farms, raised the potential for successful containment to 94%. A 10-km vaccination on day 7 or 14 after initial detection was also effective in halting the epidemics (80%), but accompanied a large number of culled or vaccinated farms. The combined strategy of 10-km vaccination and 0.5-km pre-emptive culling targeting pig farms succeeded in containing all epidemics within 100 days. The present study suggests the importance of preparedness for the 24-hr culling policy and additional control measures when an FMD outbreak occurs in a densely populated area. Considering the characteristics of the livestock area is important in planning FMD control strategies.

  17. Marketing Outputs as Art? Bringing an Aesthetic Sensibility to the Marketing Curriculum

    ERIC Educational Resources Information Center

    Petkus, Ed, Jr.; Budeva, Desislava; Chung, Christina; Dzhogleva, Hristina

    2011-01-01

    Can marketing outputs--advertising, packaging, product design, and retail environments--be considered a form of art? This paper explores the potential for incorporating the theories and concepts of aesthetics in the marketing curriculum in order to facilitate students' capacity to interpret marketing outputs and develop effective practical…

  18. Targeting the Kids: Insights into the Practice of Marketing Research.

    ERIC Educational Resources Information Center

    Bezaire, Kimberley

    1999-01-01

    Focuses on business and market research as areas that increasingly affect students and education. Notes that the children's market is big business; that the potential for marketing a wide range of children's products is increasing; and that the types of research being conducted by marketing firms include using schools. (DLH)

  19. 40 CFR 246.200-3 - Recommended procedures: Market study.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Recommended procedures: Market study... § 246.200-3 Recommended procedures: Market study. An investigation of markets should be made by the... minimum: (a) Identifying potential purchasers of the recovered paper through standard market...

  20. 40 CFR 246.202-3 - Recommended procedures: Market study.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Recommended procedures: Market study... § 246.202-3 Recommended procedures: Market study. An investigation of markets should be made by the...: (a) Identifying potential purchasers of the recovered corrugated through standard market...

  1. 40 CFR 246.200-3 - Recommended procedures: Market study.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Recommended procedures: Market study... § 246.200-3 Recommended procedures: Market study. An investigation of markets should be made by the... minimum: (a) Identifying potential purchasers of the recovered paper through standard market...

  2. 40 CFR 246.202-3 - Recommended procedures: Market study.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Recommended procedures: Market study... § 246.202-3 Recommended procedures: Market study. An investigation of markets should be made by the...: (a) Identifying potential purchasers of the recovered corrugated through standard market...

  3. 40 CFR 246.202-3 - Recommended procedures: Market study.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Recommended procedures: Market study... § 246.202-3 Recommended procedures: Market study. An investigation of markets should be made by the...: (a) Identifying potential purchasers of the recovered corrugated through standard market...

  4. 40 CFR 246.200-3 - Recommended procedures: Market study.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Recommended procedures: Market study... § 246.200-3 Recommended procedures: Market study. An investigation of markets should be made by the... minimum: (a) Identifying potential purchasers of the recovered paper through standard market...

  5. 40 CFR 246.200-3 - Recommended procedures: Market study.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Recommended procedures: Market study... § 246.200-3 Recommended procedures: Market study. An investigation of markets should be made by the... minimum: (a) Identifying potential purchasers of the recovered paper through standard market...

  6. 40 CFR 246.200-3 - Recommended procedures: Market study.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Recommended procedures: Market study... § 246.200-3 Recommended procedures: Market study. An investigation of markets should be made by the... minimum: (a) Identifying potential purchasers of the recovered paper through standard market...

  7. 40 CFR 246.202-3 - Recommended procedures: Market study.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Recommended procedures: Market study... § 246.202-3 Recommended procedures: Market study. An investigation of markets should be made by the...: (a) Identifying potential purchasers of the recovered corrugated through standard market...

  8. 17 CFR 156.3 - Contract market program for enforcement.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 2 2014-04-01 2014-04-01 false Contract market program for... (CONTINUED) BROKER ASSOCIATIONS § 156.3 Contract market program for enforcement. A contract market must, as... for potential abuse and to secure compliance with all other contract market bylaws, rules,...

  9. 40 CFR 246.202-3 - Recommended procedures: Market study.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Recommended procedures: Market study... § 246.202-3 Recommended procedures: Market study. An investigation of markets should be made by the...: (a) Identifying potential purchasers of the recovered corrugated through standard market...

  10. Prevalence and proposal for cost-effective management of the ciguatera risk in the Noumea fish market, New Caledonia (South Pacific).

    PubMed

    Clua, Eric; Brena, Pierpaolo F; Lecasble, Côme; Ghnassia, Reine; Chauvet, Claude

    2011-11-01

    Ciguatera fish poisoning (CFP) is a common intoxication associated with the consumption of reef fish, which constitutes a critical issue for public health in many countries. The complexity of its epidemiology is responsible for the poor management of the risk in tropical fish markets. We used the example of the Noumea fish market in New Caledonia to develop a cost-effective methodology of assessing the CFP risk. We first used published reports and the knowledge of local experts to define a list of potentially poisonous local species, ranked by their ciguatoxic potential. Based on two 1-month surveys in the market, conducted in winters 2008 and 2009, we then calculated the consolidated ratio of biomass of potentially poisonous species vs. total biomass of fish sold on the market. The prevalence of high CFP-risk species in the market was 16.1% and 18.9% in 2008 and 2009, respectively. The most common high CFP risk species were groupers (serranids), king mackerels (scombrids), snappers (lutjanids), barracudas (sphyaraenids), emperors (lethrinids) and wrasses (labrids). The size (age) of the fish also plays a critical role in the potential ciguatoxic risk. According to proposals of average size thresholds provided by experts for high-risk species, we were also able to assess the additional risk induced by the sale of some large fish on the market. The data collected both from experts and from the market allowed us to develop a cost-effective proposal for improving the management of the CFP risk in this market. However, the successful implementation of any regulation aiming to ban some specific species and sizes from the market, with an acceptable economical impact, will require the improvement of the expertise in fish identification by public health officers and, ideally, the commitment of retailers.

  11. Marketing netcoatings for aquaculture.

    PubMed

    Martin, Robert J

    2014-10-17

    Unsustainable harvesting of natural fish stocks is driving an ever growing marine aquaculture industry. Part of the aquaculture support industry is net suppliers who provide producers with nets used in confining fish while they are grown to market size. Biofouling must be addressed in marine environments to ensure maximum product growth by maintaining water flow and waste removal through the nets. Biofouling is managed with copper and organic biocide based net coatings. The aquaculture industry provides a case study for business issues related to entry of improved fouling management technology into the marketplace. Several major hurdles hinder entry of improved novel technologies into the market. The first hurdle is due to the structure of business relationships. Net suppliers can actually cut their business profits dramatically by introducing improved technologies. A second major hurdle is financial costs of registration and demonstration of efficacy and quality product with a new technology. Costs of registration are prohibitive if only the net coatings market is involved. Demonstration of quality product requires collaboration and a team approach between formulators, net suppliers and farmers. An alternative solution is a vertically integrated business model in which the support business and product production business are part of the same company.

  12. Marketing Netcoatings for Aquaculture

    PubMed Central

    Martin, Robert J.

    2014-01-01

    Unsustainable harvesting of natural fish stocks is driving an ever growing marine aquaculture industry. Part of the aquaculture support industry is net suppliers who provide producers with nets used in confining fish while they are grown to market size. Biofouling must be addressed in marine environments to ensure maximum product growth by maintaining water flow and waste removal through the nets. Biofouling is managed with copper and organic biocide based net coatings. The aquaculture industry provides a case study for business issues related to entry of improved fouling management technology into the marketplace. Several major hurdles hinder entry of improved novel technologies into the market. The first hurdle is due to the structure of business relationships. Net suppliers can actually cut their business profits dramatically by introducing improved technologies. A second major hurdle is financial costs of registration and demonstration of efficacy and quality product with a new technology. Costs of registration are prohibitive if only the net coatings market is involved. Demonstration of quality product requires collaboration and a team approach between formulators, net suppliers and farmers. An alternative solution is a vertically integrated business model in which the support business and product production business are part of the same company. PMID:25329615

  13. Market Brief. Status of the Voluntary Renewable Energy Certificate Market (2011 Data)

    SciTech Connect

    Heeter, Jenny; Armstrong, Philip; Bird, Lori

    2012-09-01

    This report documents the status and trends of U.S. 'voluntary' markets -- those in which consumers and institutions purchase renewable energy to match their electricity needs on a voluntary basis. Voluntary REC markets continue to exhibit growth and spur renewable energy development. Voluntary green power markets provide an additional revenue stream for renewable energy projects and raise consumer awareness of the benefits of renewable energy. Although a full estimate of the size of the voluntary market is not available for 2011, this review uses indicative metrics to capture 2011 voluntary market trends.

  14. Market Brief: Status of the Voluntary Renewable Energy Certificate Market (2011 Data)

    SciTech Connect

    Heeter, J.; Armstrong, P.; Bird, L.

    2012-09-01

    This report documents the status and trends of U.S. 'voluntary' markets -- those in which consumers and institutions purchase renewable energy to match their electricity needs on a voluntary basis. Voluntary REC markets continue to exhibit growth and spur renewable energy development. Voluntary green power markets provide an additional revenue stream for renewable energy projects and raise consumer awareness of the benefits of renewable energy. Although a full estimate of the size of the voluntary market is not available for 2011, this review uses indicative metrics to capture 2011 voluntary market trends.

  15. Barriers to the Use of Trastuzumab for HER2+ Breast Cancer and the Potential Impact of Biosimilars: A Physician Survey in the United States and Emerging Markets.

    PubMed

    Lammers, Philip; Criscitiello, Carmen; Curigliano, Giuseppe; Jacobs, Ira

    2014-09-17

    Trastuzumab in combination with chemotherapy has become a standard of care for patients with HER2+ breast cancer. The cost of therapy, however, can limit patient access to trastuzumab in areas with limited financial resources for treatment reimbursement. This study examined access to trastuzumab and identified potential barriers to its use in the United States, Mexico, Turkey, Russia and Brazil via physician survey. The study also investigated if the availability of a biosimilar to trastuzumab would improve access to and use of HER2 monoclonal antibody therapy. Across all countries, a subset of oncologists reported barriers to the use of trastuzumab in a neoadjuvant, adjuvant or metastatic setting. Common barriers to the use of trastuzumab included issues related to insurance coverage, drug availability and cost to the patient. Overall, nearly half of oncologists reported that they would increase the use of HER2 monoclonal antibody therapy across all treatment settings if a lower cost biosimilar to trastuzumab were available. We conclude that the introduction of a biosimilar to trastuzumab may alleviate cost-related barriers to treatment and could increase patient access to HER2-directed therapy in all countries examined.

  16. Evaluation of In Vivo Osteogenic Potential of Bone Morphogenetic Protein 2-Overexpressing Human Periodontal Ligament Stem Cells Combined with Biphasic Calcium Phosphate Block Scaffolds in a Critical-Size Bone Defect Model.

    PubMed

    Yi, TacGhee; Jun, Choong-Man; Kim, Su Jin; Yun, Jeong-Ho

    2016-03-01

    Human periodontal ligament stem cells (hPDLSCs) are considered potential cellular carriers for gene delivery in the field of tissue regeneration. This study tested the osseoregenerative potential of hPDLSCs transduced with replication-deficient recombinant adenovirus (rAd) containing the gene encoding bone morphogenetic protein-2 (BMP2; hPDLSCs/rAd-BMP2) in both in vivo and in vitro osteogenic environments. After the optimal condition for rAd-mediated transduction was determined, hPDLSCs were transduced to express BMP2. In vivo bone formation was evaluated in a critical-size rat calvarial bone defect model that more closely mimics the harsher in vivo milieu for bone regeneration than subcutaneous transplantation model. As support materials for bone regeneration, block-type biphasic calcium phosphate (BCP) scaffolds were combined with hPDLSCs and/or BMP2 and transplanted into critical-size bone defects in rats. Experimental groups were as follows: BCP scaffold control (group 1 [Gr1]), scaffold containing recombinant human BMP2 (rhBMP2; group 2 [Gr2]), scaffold loaded with normal hPDLSCs (group 3 [Gr3]), scaffold combined with both normal hPDLSCs and rhBMP2 (group 4 [Gr4]), and scaffold loaded with hPDLSCs transduced with rAd-BMP2 (hPDLSCs/rAd-BMP2; group 5 [Gr5]). Our data showed that new bone formation was highest in Gr2. Less mineralization was observed in Gr3, Gr4, and Gr5 in which hPDLSCs were transplanted. In vitro transwell assay demonstrated that hPDLSCs exert an inhibitory activity on BMP2-induced osteogenic differentiation. Our findings suggest that the in vivo bone regenerative potential of BMP2-overexpressing hPDLSCs could be compromised in a critical-size rat calvarial bone defect model. Thus, further investigations are required to elucidate the underlying mechanisms and to develop efficient techniques for improved tissue regeneration.

  17. Investigating the effects of particle size and chemical structure on cytotoxicity and bacteriostatic potential of nano hydroxyapatite/chitosan/silica and nano hydroxyapatite/chitosan/silver; as antibacterial bone substitutes

    NASA Astrophysics Data System (ADS)

    Tavakol, Shima; Nikpour, Mohammad Reza; Hoveizi, Elham; Tavakol, Behnaz; Rezayat, Seyed Mahdi; Adabi, Mahdi; Shajari Abokheili, Sahebeh; Jahanshahi, Mohsen

    2014-10-01

    The restoration of defective bone tissue and complications related to surgery and fracture site infection are major concerns in orthopedic surgeries. However, it is crucial to develop osteoconductive and bacteriostatic composites. Chitosan/nano hydroxyapatite (CT/n-HAp) powder containing of Ag and Si were prepared by an in situ hybridization method. The aim of this work was to elucidate the effect of size, surface roughness, and chemical structure of mentioned nanocomposites on cytotoxicity and bacteriostatic activity via human osteoblast cells and Escherichia Coli, respectively. Particle size, surface roughness, reactive oxygen specious production, and bioactivity of nanocomposites were investigated by X ray diffraction, atomic force microscopy, DPPH assay, and SEM/UV-Visible spectrophotometer, respectively. Bacterial colony counting test, MTT assay and lactate dehydrogenase (LDH) release were performed as bacteriostatic and biocompatibility tests. The results showed that CT/n-HAp/Ag with smaller particle size in the range of 1-22.6 nm (10.00 ± 0.09 nm) than CT/n-HAp/Si in the range of 3-72.5 nm (18.00 ± 0.14 nm) exhibits higher cell viability and bacteriostatic activity, and less LDH release from cell plasma membrane. Integration of Ag into the nanocomposite hindered the release of Ag+ ions and restricts cytotoxic potential on cells. Higher cytotoxic effect of CT/n-HAp/Si might be related to proton concentration derived from nanocomposite and its chemical structure. In conclusion, the strong bone regeneration potential of CT/n-HAp and good biocompatibility and bacteriostatic activity of CT/n-HAp/Ag make it as potential bacteriostatic bone filler in site of infected bone fracture.

  18. Small firm subsistence and market dimensionality

    NASA Astrophysics Data System (ADS)

    Bruggeman, Jeroen; Péli, Gábor

    2014-04-01

    In many markets, large and small firms coexist. As large firms can in principle out-compete small ones, the actual presence of the latter asks for an explanation. In ours, we focus on the dimensionality of markets, which can change as a consequence of product innovations, preference elaboration or institutions. We show that increasing market dimensionality substantially enlarges the market periphery relative to the market center, which creates new potential niches for small firms. We thereby provide a parsimonious explanation for small firm subsistence.

  19. Solvable stochastic dealer models for financial markets

    NASA Astrophysics Data System (ADS)

    Yamada, Kenta; Takayasu, Hideki; Ito, Takatoshi; Takayasu, Misako

    2009-05-01

    We introduce solvable stochastic dealer models, which can reproduce basic empirical laws of financial markets such as the power law of price change. Starting from the simplest model that is almost equivalent to a Poisson random noise generator, the model becomes fairly realistic by adding only two effects: the self-modulation of transaction intervals and a forecasting tendency, which uses a moving average of the latest market price changes. Based on the present microscopic model of markets, we find a quantitative relation with market potential forces, which have recently been discovered in the study of market price modeling based on random walks.

  20. Marketing strategies for the cosmetic practice.

    PubMed

    Austin, C J

    1994-01-01

    Appropriate marketing business systems need to be in place to attract and sustain a cosmetic dentistry patient base. Marketing for this sector is most effective when consistently patterned after businesses with high-end consumer services and products. Motivating patients of record and potential new patients to choose cosmetic dental services involves implementing both basic marketing and a series of cosmetic-specific marketing strategies. Consultants are valuable for the process of developing a strategic plan and making recommendations for developing new marketing business systems.

  1. Occurrence of Potential Bacterial Pathogens and Their Antimicrobial Susceptibility Patterns Isolated from Herbal Medicinal Products Sold in Different Markets of Gondar Town, Northwest Ethiopia

    PubMed Central

    Yesuf, Abdela; Wondimeneh, Yitayih; Gebrecherkos, Teklay; Moges, Feleke

    2016-01-01

    Background. The World Health Organization estimates that about 80% of the world's population uses herbal medicine to treat various illnesses as means of primary healthcare. However, during preparation, herbal plants may be exposed to contamination by potential pathogens, and this may lead to infections. The aim of this study was to determine bacterial contamination of herbal medicinal products and to assess the antibiotic susceptibility pattern of the isolated bacteria. Methods. A cross-sectional study was conducted from January 1 to May 25, 2013, at Gondar Town. A total of 55 samples used as oral, local, and intranasal routes of administration were collected from the herbalists. Results. In the present study the total aerobic bacterial count ranges from zero to 2.41 × 109 CFU/g with mean count of 1.99 × 108 CFU/g or mL while the total coliform count showed an average of 1.05 × 108 CFU/g or mL with a range of zero to 2.1 × 109 CFU/g. The most common bacteria isolated were Bacillus spp. followed by Enterobacter spp., Shigella dysenteriae, and Salmonella spp. Multiple drug resistance was not uncommon and it was found that 125 (83.4%) of the isolates were resistant to two or more antibiotics. Conclusion. Herbal medicinal preparations were highly contaminated with pathogenic microorganisms with high microbial load. Most of the isolates have multiple drug resistance. Using those contaminated herbal medicines may lead to infection of other health related risks. Therefore, this warrants urgent training of herbalists and management scale-up for quality and safety of medicinal plants. PMID:27299154

  2. Marketing to the Homosexual (gay) market: a profile and strategy implications.

    PubMed

    DeLozier, M W; Rodrigue, J

    1996-01-01

    This article describes a significant market to which marketers must devote greater attention. The gay market is well-educated, has high discretionary income, is informed socially and politically, is dedicated to career and home ownership, and places greater importance on friendship networks than do most Americans. Although a potentially lucrative market segment, gays represent a difficult segment to reach since alienation by other segments could be an explosive factor for many businesses.

  3. Marketing and planning in multihospital systems.

    PubMed

    Gourley, D R; Moore, M E

    1988-01-01

    Marketing and planning functions at the corporate level of multihospital systems are examined. Drawing on the experiences of executives in 30 multihospital systems located in the United States west of the Mississippi, this article describes the differences in the marketing and planning functions by for-profit, not-for-profit, and church-owned multihospital systems; examines the impact of age, number of hospitals, and average hospital bed size of the systems; provides insights regarding the primary persons involved in the marketing and planning functions; and highlights the important future of marketing and planning by the top management of multihospital systems.

  4. Views on world markets - Canada

    SciTech Connect

    Passmore, J.

    1996-12-31

    If {open_quotes}market{close_quotes} is defined by hardware in the ground (as it should be), then the Canadian wind power market has been virtually non-existent (only 23 MW to date). The potential on the other hand is enormous (6400 MW likely to be developed). This potential has not been pursued because of unregulated electric utility monopolies, lack of political knowledge and interest, and punitive tax treatment for renewables. Recent initiatives including utility restructuring, federal plans for green power procurement, and proposed tax measures suggest that situation has potential for change. Interested parties should start familiarizing themselves with the Canadian players / market now, in order to be ready to move when the time comes (likely in the next three years). 3 tabs.

  5. Marketing in nursing organizations.

    PubMed

    Chambers, S B

    1989-05-01

    The purpose of chapter 3 is to provide a conceptual framework for understanding marketing. Although it is often considered to be, marketing is not really a new activity for nursing organizations. What is perhaps new to most nursing organizations is the conduct of marketing activities as a series of interrelated events that are part of a strategic marketing process. The increasingly volatile nursing environment requires a comprehensive approach to marketing. This chapter presents definitions of marketing, the marketing mix, the characteristics of nonprofit marketing, the relationship of strategic planning and strategic marketing, portfolio analysis, and a detailed description of the strategic marketing process. While this chapter focuses on marketing concepts, essential components, and presentation of the strategic marketing process, chapter 4 presents specific methods and techniques for implementing the strategic marketing process.

  6. Size Matters

    PubMed Central

    Long, Kimberly; Abuelenen, Toaa; Pava, Libia; Bastille, Maya

    2011-01-01

    We tallied the number of possible mutant amino acids in proteins thought to be inactivated early in tumorigenesis and in proteins thought to be inactivated late in tumorigenesis, respectively. Proteins thought to be inactivated early in tumorigenesis, on average, have a greater number of alternative, mutant possibilities, which raises the possibility that the sequential order of mutations associated with cancer development reflects the random chance, throughout life, of a mutagen inactivating a larger versus a smaller target. The hypothesis that the temporal order of genetic changes in cancer reflects mutagen target sizes leads to novel considerations of 1) the mechanisms of the acquisition of cancer hallmarks and 2) cancer screening strategies. PMID:22701759

  7. Managing the market. Focusing on a select group of customers can keep an organization competitive.

    PubMed

    MacStravic, R S

    1989-05-01

    The real challenge in healthcare marketing today is managing markets, focusing on selected groups of customers rather than on the organization or its services. Market management includes three distinct but related levels: Strategic market management assesses current and potential markets and chooses those the organization can serve best; segment management focuses on the needs and wants of subsets of chosen customers; and customer management reinforces long-term commitments to the organization. The patient care experience can be broken down into specific contacts with each staff member. The key to managing the experience is to identify and achieve standards of performance for each contact by examining what each event means to the patients and how patients judge each staff member, as well as the overall care experience. Regular feedback helps. An unavoidable risk in market management is that a given segment may decline in size, in need for services, or in cohesiveness as a segment. Yet those organizations which can identify the right segments and "manage" them effectively will have an advantage in a competitive market.

  8. 7 CFR 905.8 - Prepare for market.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Prepare for market. 905.8 Section 905.8 Agriculture... TANGELOS GROWN IN FLORIDA Order Regulating Handling Definitions § 905.8 Prepare for market. Prepare for market means to wash, grade, size, or place fruit (whether or not wrapped) into any container...

  9. 7 CFR 905.8 - Prepare for market.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Prepare for market. 905.8 Section 905.8 Agriculture... TANGELOS GROWN IN FLORIDA Order Regulating Handling Definitions § 905.8 Prepare for market. Prepare for market means to wash, grade, size, or place fruit (whether or not wrapped) into any container...

  10. The U.S. Hispanic Market: An Overview.

    ERIC Educational Resources Information Center

    Hundley, James E.

    A review of the American Hispanic market looks at the size and characteristics of the Hispanic population and its economic patterns. It begins by examining separate markets and cultural groups and the issue of whether the market is assimilating or internally homogeneous. General and ethnic-related demographics are then examined, including data on…

  11. 7 CFR 905.8 - Prepare for market.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Prepare for market. 905.8 Section 905.8 Agriculture... TANGELOS GROWN IN FLORIDA Order Regulating Handling Definitions § 905.8 Prepare for market. Prepare for market means to wash, grade, size, or place fruit (whether or not wrapped) into any container...

  12. 7 CFR 905.8 - Prepare for market.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Prepare for market. 905.8 Section 905.8 Agriculture... TANGELOS GROWN IN FLORIDA Order Regulating Handling Definitions § 905.8 Prepare for market. Prepare for market means to wash, grade, size, or place fruit (whether or not wrapped) into any container...

  13. 7 CFR 905.8 - Prepare for market.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Prepare for market. 905.8 Section 905.8 Agriculture... TANGELOS GROWN IN FLORIDA Order Regulating Handling Definitions § 905.8 Prepare for market. Prepare for market means to wash, grade, size, or place fruit (whether or not wrapped) into any container...

  14. Marketing II Workbook.

    ERIC Educational Resources Information Center

    Reeves, Cheryl

    This combination curriculum and workbook, which was originally developed for use in a training workshop, is intended to assist adult educators in learning to market their adult literacy programs. The first chapter reviews basic marketing concepts (the definition of marketing, 10 truths about marketing, marketing versus promotion, steps in…

  15. The Market Linkage.

    ERIC Educational Resources Information Center

    Fuchs, Victor E.

    The Market Linkage Project (ML) for Special Education and the Basic Skills Validation and Marketing Program are two federally sponsored marketing projects developed under contract by LINC Resources, Inc., a professional marketing organization, for the U.S. Department of Education. LINC developed the marketing programs to provide the option for the…

  16. Markets for compost

    SciTech Connect

    Not Available

    1993-11-01

    Table of Contents: Introduction; Characteristics and Benefits of Compost and Competing/Complementary Products; Compost Uses and Markets; Factors Pertinent to Developing Compost Markets; Compost Specifications; Compost Testing Requirements; Compost Distribution; Compost Policies; Economic and Noneconomic Barriers to Developing Compost Markets; Strategies to Mitigate/Overcome Barriers to Developing Compost Markets; and Examples of Existing Programs and Markets (as of 1989).

  17. Marketing the College Union.

    ERIC Educational Resources Information Center

    Hoef, Ted; Howe, Nanci

    Theory underlying marketing in the public sector is presented in combination with specific examples of marketing strategies and techniques used in college unions and student activities programs across the country. The subject of marketing is discussed under six major subject headings: (1) why marketing? (2) analyzing marketing opportunities; (3)…

  18. Introduction to Electronic Marketing.

    ERIC Educational Resources Information Center

    Dilbeck, Lettie

    These materials for a five-unit course were developed to introduce secondary and postsecondary students to the use of electronic equipment in marketing. The units cover the following topics: electronic marketing as a valid marketing approach; telemarketing; radio electronic media marketing; television electronic media marketing; and cable TV…

  19. Tailoring hospital marketing efforts to physicians' needs.

    PubMed

    Mackay, J M; Lamb, C W

    1988-12-01

    Marketing has become widely recognized as an important component of hospital management (Kotler and Clarke 1987; Ludke, Curry, and Saywell 1983). Physicians are becoming recognized as an important target market that warrants more marketing attention than it has received in the past (Super 1987; Wotruba, Haas, and Hartman 1982). Some experts predict that hospitals will begin focusing more marketing attention on physicians and less on consumers (Super 1986). Much of this attention is likely to take the form of practice management assistance, such as computer-based information system support or consulting services. The survey results reported here are illustrative only of how one hospital addressed the problem of physician need assessment. Other potential target markets include physicians who admit patients only to competitor hospitals and physicians who admit to multiple hospitals. The market might be segmented by individual versus group practice, area of specialization, or possibly even physician practice life cycle stage (Wotruba, Haas, and Hartman 1982). The questions included on the survey and the survey format are likely to be situation-specific. The key is the process, not the procedure. It is important for hospital marketers to recognize that practice management assistance needs will vary among markets (Jensen 1987). Therefore, hospitals must carefully identify their target physician market(s) and survey them about their specific needs before developing and implementing new physician marketing programs. Only then can they be reasonably confident that their marketing programs match their customers' needs.

  20. Fishing degrades size structure of coral reef fish communities.

    PubMed

    Robinson, James P W; Williams, Ivor D; Edwards, Andrew M; McPherson, Jana; Yeager, Lauren; Vigliola, Laurent; Brainard, Russell E; Baum, Julia K

    2017-03-01

    Fishing pressure on coral reef ecosystems has been frequently linked to reductions of large fishes and reef fish biomass. Associated impacts on overall community structure are, however, less clear. In size-structured aquatic ecosystems, fishing impacts are commonly quantified using size spectra, which describe the distribution of individual body sizes within a community. We examined the size spectra and biomass of coral reef fish communities at 38 US-affiliated Pacific islands that ranged in human presence from near pristine to human population centers. Size spectra 'steepened' steadily with increasing human population and proximity to market due to a reduction in the relative biomass of large fishes and an increase in the dominance of small fishes. Reef fish biomass was substantially lower on inhabited islands than uninhabited ones, even at inhabited islands with the lowest levels of human presence. We found that on populated islands size spectra exponents decreased (analogous to size spectra steepening) linearly with declining biomass, whereas on uninhabited islands there was no relationship. Size spectra were steeper in regions of low sea surface temperature but were insensitive to variation in other environmental and geomorphic covariates. In contrast, reef fish biomass was highly sensitive to oceanographic conditions, being influenced by both oceanic productivity and sea surface temperature. Our results suggest that community size structure may be a more robust indicator than fish biomass to increasing human presence and that size spectra are reliable indicators of exploitation impacts across regions of different fish community compositions, environmental drivers, and fisheries types. Size-based approaches that link directly to functional properties of fish communities, and are relatively insensitive to abiotic variation across biogeographic regions, offer great potential for developing our understanding of fishing impacts in coral reef ecosystems.

  1. Marketing By Objectives: How to Write a Marketing Plan and What to Do with It Once You've Got It.

    ERIC Educational Resources Information Center

    McNutt, Diane

    1983-01-01

    A checklist of elements that should appear in every college's marketing plan are included: objectives, a market analysis, a list of potential markets, ideal marketing plan for each market or audience, a modified plan that fits needs and capabilities, and an accurate timeline and budget for the revised plan. (MLW)

  2. Medical device market in China.

    PubMed

    Boyer, Philip; Morshed, Bashir I; Mussivand, Tofy

    2015-06-01

    With China's growing old-age population and economic presence on the international stage, it has become important to evaluate its domestic and foreign market contribution to medical devices. Medical devices are instruments or apparatuses used in the prevention, rehabilitation, treatment, or knowledge generation with respect to disease or other abnormal conditions. This article provides information drawn from recent publications to describe the current state of the Chinese domestic market for medical devices and to define opportunities for foreign investment potential therein. Recent healthcare reforms implemented to meet rising demand due to an aging and migrating population are having a positive effect on market growth-a global market with a projected growth of 15% per year over the next decade.

  3. Recognizing misleading pharmaceutical marketing online.

    PubMed

    De Freitas, Julian; Falls, Brian A; Haque, Omar S; Bursztajn, Harold J

    2014-01-01

    In light of decision-making psychology, this article details how drug marketing operates across established and novel web domains and identifies some common misleading trends and influences on prescribing and patient-initiated medication requests. The Internet has allowed pharmaceutical marketing to become more salient than ever before. Although the Internet's growth has improved the dissemination of pharmaceutical information, it has also led to the increased influence of misleading pharmaceutical marketing. Such mismarketing is of concern, especially in psychiatry, since psychotropics generate considerable revenue for drug companies. In a climate of resource-limited drug regulation and time-strapped physicians, we recommend improving both independent monitoring and consumer awareness of Internet-enabled, potentially misleading, pharmaceutical marketing influences.

  4. Assessing Consumer Values and the Supply-Chain Market for the Integrated Water Heater/Dehumidifier

    SciTech Connect

    Ashdown, BG

    2005-01-11

    This paper presents a case study of the potential market for the dual-service residential integrated water heater/dehumidifier (WHD). Its principal purpose is to evaluate the extent to which this integrated appliance might penetrate the residential market sector, given current market trends, producer and consumer attributes, and technical parameters. The report's secondary purpose is to gather background information leading to a generic framework for conducting market analyses of technologies. This framework can be used to assess market readiness as well as factor preferred product attributes into the design to drive consumer demand for this product. This study also supports analysis for prototype design. A full market analysis for potential commercialization should be conducted after prototype development. The integrated WHD is essentially a heat-pump water heater (HPWH) with components and controls that allow dedicated dehumidification. Adequate residential humidity control is a growing issue for newly constructed residential homes, which are insulated so well that mechanical ventilation may be necessary to meet fresh air requirements. Leveraging its successful experience with the energy-efficient design improvement for the residential HPWH, the Oak Ridge National Laboratory's (ORNL's) Engineering Science and Technology Division's (ESTD's) Building Equipment Group designed a water-heating appliance that combines HPWH efficiency with dedicated dehumidification. This integrated appliance could be a low-cost solution for dehumidification and efficient electric water heating. ORNL is partnering with Western Carolina University, Asheville-Buncombe Technical Community College, American Carolina Stamping Company, and Clemson University to develop this appliance and assess its market potential. For practical purposes, consumers are indifferent to how water is heated but are very interested in product attributes such as initial first cost, operating cost, performance

  5. Fuel cell market applications

    SciTech Connect

    Williams, M.C.

    1995-12-31

    This is a review of the US (and international) fuel cell development for the stationary power generation market. Besides DOE, GRI, and EPRI sponsorship, the US fuel cell program has over 40% cost-sharing from the private sector. Support is provided by user groups with over 75 utility and other end-user members. Objectives are to develop and demonstrate cost-effective fuel cell power generation which can initially be commercialized into various market applications using natural gas fuel by the year 2000. Types of fuel cells being developed include PAFC (phosphoric acid), MCFC (molten carbonate), and SOFC (solid oxide); status of each is reported. Potential international applications are reviewed also. Fuel cells are viewed as a force in dispersed power generation, distributed power, cogeneration, and deregulated industry. Specific fuel cell attributes are discussed: Fuel cells promise to be one of the most reliable power sources; they are now being used in critical uninterruptible power systems. They need hydrogen which can be generated internally from natural gas, coal gas, methanol landfill gas, or other fuels containing hydrocarbons. Finally, fuel cell development and market applications in Japan are reviewed briefly.

  6. Marketing through Video Presentations.

    ERIC Educational Resources Information Center

    Newhart, Donna

    1989-01-01

    Discusses the advantages of using video presentations as marketing tools. Includes information about video news releases, public service announcements, and sales/marketing presentations. Describes the three stages in creating a marketing video: preproduction planning; production; and postproduction. (JOW)

  7. Implementing the "Marketing You" Project in Large Sections of Principles of Marketing

    ERIC Educational Resources Information Center

    Smith, Karen H.

    2004-01-01

    There is mounting pressure on business education to increase experiential learning at the same time that budget constraints are forcing universities to increase class size. This article explains the design and implementation of the "Marketing You" project in two large sections of Principles of Marketing to bring experiential learning into the…

  8. Market Impact and Order Book Characteristics in the Korean Futures Market

    NASA Astrophysics Data System (ADS)

    Lee, Junghoon; Youn, Janghyuk; Chang, Woojin

    We have examined the order book characteristics and market impact on the Korean stock index futures market (KOSPI 200 index futures). The distribution of order volumes generally follows power-law distribution. The estimated exponents are 1.9 for market order, 2.5 for limit order, and 2.1 for cancel order. This result is different from the case of stocks where the exponent of market order is larger than that of limit order. The order likelihood is distinctively high in every 50's of order volume, which implies the behavioral characteristics of human preference on round-up numbers. The distributions of bid-ask spread and the best quotes volume provide the evidence of the liquidity of KOSPI 200 index futures market. We have obtained the concave relationship between market impact and transaction volume as well. Finally, the market response behavior is observed regarding various transaction sizes. The size of market response is estimated to be proportional to the size of transaction. Also, the larger the transaction size is, the longer it takes to recover the stability from the impact triggered by transaction.

  9. Marketing is everything.

    PubMed

    McKenna, R

    1991-01-01

    Technology is creating customer choice, and choice is altering the marketplace. Gone are the days of the marketer as salesperson. Gone as well is marketing that tries to trick the customer into buying whatever the company makes. There is a new paradigm for marketing, a model that depends on the marketer's knowledge, experience, and ability to integrate the customer and the company. Six principles are at the heart of the new marketing. The first, "Marketing is everything and everything is marketing," suggests that marketing is like quality. It is not a function but an all-pervasive way of doing business. The second, "The goal of marketing is to own the market, not just to sell the product," is a remedy for companies that adopt a limiting "market-share mentality." When you own a market, you lead the market. The third principle says that "marketing evolves as technology evolves." Programmable technology means that companies can promise customers "any thing, any way, any time." Now marketing is evolving to deliver on that promise. The fourth principle, "Marketing moves from monologue to dialogue," argues that advertising is obsolete. Talking at customers is no longer useful. The new marketing requires a feedback loop--a dialogue between company and customer. The fifth principle says that "marketing a product is marketing a service is marketing a product." The line between the categories is fast eroding: the best manufacturing companies provide great service, the best service companies think of themselves as offering high-quality products. The sixth principle, "Technology markets technology," points out the inevitable marriage of marketing and technology and predicts the emergence of marketing workstations, a marketing counterpart to engineers' CAD/CAM systems.

  10. Potential market of wind farm in China

    SciTech Connect

    Pengfei Shi

    1996-12-31

    Wind energy resources are abundant in China, in southeast coast area along with the rapid economic growth, electricity demand has been sharply increased, due to complex terrain detailed assessments are in urgent need. Advanced methodology and computer model should be developed. In this paper the existing wind farms, installed capacity, manufacturers share and projects in the near future are presented. For further development of wind farm in large scale, different ways of local manufacturing wind turbine generators (WTG) are going on. Current policy and barriers are analyzed. 4 refs., 2 figs., 4 tabs.

  11. New market potential: Torrefaction of Woody Biomass

    SciTech Connect

    Jaya Shankar Tumuluru; J. Richard Hess

    2015-07-01

    According to researchers in Idaho National Laboratory’s Bioenergy Program, torrefaction of woody biomass could reduce variability in biomass feedstock and enable development of a commodity-type product for green energy generation and usage.

  12. New market potential: Torrefaction of woody biomass

    SciTech Connect

    Tumuluru, Jaya Shankar; Hess, J. Richard

    2015-06-02

    Biomass was the primary source of energy worldwide until a few generations ago, when the energy-density, storability and transportability of fossil fuels enabled one of the most rapid cultural transformations in the history of humankind: the industrial revolution. In just a few hundred years, coal, oil and natural gas have prompted the development of highly efficient, high-volume manufacturing and transportation systems that have become the foundation of the world economy. But over-reliance on fossil resources has also led to environmental and energy security concerns. In addition, one of the greatest advantages of using biomass to replace fossil fuels is reduced greenhouse gas emissions and carbon footprint.

  13. LIGHTING CONTROLS: SURVEY OF MARKET POTENTIAL

    SciTech Connect

    Verderber, R.R.; Rubinstein, F.

    1982-09-01

    This study describes the impact of lighting management systems that dynamically control lights in accordance with the needs of occupants. Various control strategies are described: scheduling, tuning, lumen depreciation, and daylighting. From initial experimental results, the energy savings provided by each of the above strategies are estimated to be 26, 12, 14, and 15%, respectively. Based upon a cost of $0.05-0.10 per kWh for electric energy and a 2-, 3-, or 4-yr payback, target costs for a simple and a sophisticated lighting management system are found to be $0.24 and 1.89 per ft{sup 2}, respectively, for a cost-effective investment. A growth model, based upon an extrapolation of the increase in building stock since 1975, indicates that the commercial and industrial (C and I) building stock will grow from 40 x 10{sup 9} ft{sup 2} in 1980 to about 67 x 10{sup 9} ft{sup 2} by the year 2000. Even with the use of more efficient lighting components, the energy required for this additional C and I stock will be 307 x 10{sup 9} kWh, an increase of only 13 x 10{sup 9} kWh above current use. The specified information is used to analyze the economic impacts that using these systems will have on the lighting industry, end users, utility companies, and the nation's economy. A $1 - 4 x 10{sup 9} annual lighting control industry can be generated, creating many jobs. The estimated return on investment (ROI) for controls for end users would be between 19 and 38%. Utilities will be able to make smaller additions to capacity and invest less capital at 7-10% ROI. Finally, the annual energy savings, up to $3.4 x 10{sup 9} for end users and about $5 x 10{sup 9} for utilities, representing unneeded generating capacity, will be available to capitalize other areas of the economy.

  14. Marketing Online Services: Product, Market and Strategy.

    ERIC Educational Resources Information Center

    Trudell, Libby

    1991-01-01

    Describes characteristics of the online marketplace. Topics discussed include technology barriers; data ownership; markets for online services, including libraries and end users; marketing and promotion tactics, including exhibits and conferences, advertising, direct mail, and user groups; international marketing and service; strategic marketing…

  15. Interaction of Compliance and Voluntary Renewable Energy Markets

    SciTech Connect

    Bird, Lori; Lokey, Elizabeth

    2007-10-01

    In recent years, both compliance and voluntary markets have emerged to help support the development of renewable energy resources. Both of these markets are growing rapidly and today about half of U.S. states have RPS policies in place, with a number of these policies adopted in the last several years. In addition, many states have recently increased the stringency of their RPS policies. This paper examines key market interaction issues between compliance and voluntary renewable energy markets. It provides an overview of both the compliance and voluntary markets, addressing each market's history, purpose, size, scope, and benefits while addressing issues, including double counting.

  16. Total Marketing: A Study of Image

    DTIC Science & Technology

    1990-08-01

    marketing , and advertising are all successful in creating an initial awareness of the military. Potential recruits see recruiters at their schools, they...Direct mail marketing is impressive at first but soon wears out. It does not seem to provide new information. " Advertising , to the extent that it...awareness, current recruiting efforts net out as: Recruiter Contact - Negative Advertising - Neutral Direct Marketing - Neutral * 2. Recruitment Stage

  17. Mining Marketing Data

    NASA Technical Reports Server (NTRS)

    2002-01-01

    MarketMiner(R) Products, a line of automated marketing analysis tools manufactured by MarketMiner, Inc., can benefit organizations that perform significant amounts of direct marketing. MarketMiner received a Small Business Innovation Research (SBIR) contract from NASA's Johnson Space Center to develop the software as a data modeling tool for space mission applications. The technology was then built into the company current products to provide decision support for business and marketing applications. With the tool, users gain valuable information about customers and prospects from existing data in order to increase sales and profitability. MarketMiner(R) is a registered trademark of MarketMiner, Inc.

  18. Determinants of Market Structure and the Airline Industry

    NASA Technical Reports Server (NTRS)

    Raduchel, W.

    1972-01-01

    The general economic determinants of market structure are outlined with special reference to the airline industry. Included are the following facets: absolute size of firms; distributions of firms by size; concentration; entry barriers; product and service differentiation; diversification; degrees of competition; vertical integration; market boundaries; and economies of scale. Also examined are the static and dynamic properties of market structure in terms of mergers, government policies, and economic growth conditions.

  19. 7 CFR 29.3591 - Standard tobacco sizes. 1

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Standard tobacco sizes. 1 29.3591 Section 29.3591 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... REGULATIONS TOBACCO INSPECTION Standards Sizes § 29.3591 Standard tobacco sizes. 1 Inches Sizes 12-20 1...

  20. 7 CFR 29.3591 - Standard tobacco sizes. 1

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Standard tobacco sizes. 1 29.3591 Section 29.3591 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... REGULATIONS TOBACCO INSPECTION Standards Sizes § 29.3591 Standard tobacco sizes. 1 Inches Sizes 12-20 1...

  1. 7 CFR 29.3591 - Standard tobacco sizes. 1

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Standard tobacco sizes. 1 29.3591 Section 29.3591 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... REGULATIONS TOBACCO INSPECTION Standards Sizes § 29.3591 Standard tobacco sizes. 1 Inches Sizes 12-20 1...

  2. 7 CFR 29.3591 - Standard tobacco sizes. 1

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Standard tobacco sizes. 1 29.3591 Section 29.3591 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... REGULATIONS TOBACCO INSPECTION Standards Sizes § 29.3591 Standard tobacco sizes. 1 Inches Sizes 12-20 1...

  3. 7 CFR 29.3591 - Standard tobacco sizes. 1

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Standard tobacco sizes. 1 29.3591 Section 29.3591 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... REGULATIONS TOBACCO INSPECTION Standards Sizes § 29.3591 Standard tobacco sizes. 1 Inches Sizes 12-20 1...

  4. Brazil's Market for Trading Forest Certificates.

    PubMed

    Soares-Filho, Britaldo; Rajão, Raoni; Merry, Frank; Rodrigues, Hermann; Davis, Juliana; Lima, Letícia; Macedo, Marcia; Coe, Michael; Carneiro, Arnaldo; Santiago, Leonardo

    2016-01-01

    Brazil faces an enormous challenge to implement its revised Forest Code. Despite big losses for the environment, the law introduces new mechanisms to facilitate compliance and foster payment for ecosystem services (PES). The most promising of these is a market for trading forest certificates (CRAs) that allows landowners to offset their restoration obligations by paying for maintaining native vegetation elsewhere. We analyzed the economic potential for the emerging CRA market in Brazil and its implications for PES programs. Results indicate a potential market for trading 4.2 Mha of CRAs with a gross value of US$ 9.2±2.4 billion, with main regional markets forming in the states of Mato Grosso and São Paulo. This would be the largest market for trading forests in the world. Overall, the potential supply of CRAs in Brazilian states exceeds demand, creating an opportunity for additional PES programs to use the CRA market. This expanded market could provide not only monetary incentives to conserve native vegetation, but also environmental co-benefits by fostering PES programs focused on biodiversity, water conservation, and climate regulation. Effective implementation of the Forest Code will be vital to the success of this market and this hurdle brings uncertainty into the market. Long-term commitment, both within Brazil and abroad, will be essential to overcome the many challenges ahead.

  5. Issues in Water Quality Trading: Perspectives on the Market-Based Approach

    EPA Science Inventory

    Market mechanisms and incentives can play an important role in addressing environmental problems. Potential advantages of using market-based approaches include reducing the costs of meeting environmental goals and encouraging innovation. One market mechanism that has been promo...

  6. Marketing considerations in home health care.

    PubMed

    Tanner, D J

    1985-12-01

    Methods for conducting a comprehensive analysis of the potential for strategic entry or expansion in the home health-care (HHC) market are discussed. By conducting a comprehensive analysis of the HHC market, hospital pharmacists can evaluate the feasibility of developing and implementing a hospital-based HHC service. A comprehensive market analysis should include an initial assessment of potential product-line offerings, development of strengths-and-weaknesses and opportunities-and-threats profiles, evaluations of competing providers of HHC and regulatory issues, and formulation of a business plan. The potential impact of program structure, operations management, product pricing, advertising and promotion, and marketing controls should also be considered. The hospital pharmacist has a unique opportunity to further the organizational objectives of the hospital by participating in the provision of HHC; a comprehensive market analysis represents a useful method of assessing the benefits and costs associated with providing integrated HHC services.

  7. Statistical pairwise interaction model of stock market

    NASA Astrophysics Data System (ADS)

    Bury, Thomas

    2013-03-01

    Financial markets are a classical example of complex systems as they are compound by many interacting stocks. As such, we can obtain a surprisingly good description of their structure by making the rough simplification of binary daily returns. Spin glass models have been applied and gave some valuable results but at the price of restrictive assumptions on the market dynamics or they are agent-based models with rules designed in order to recover some empirical behaviors. Here we show that the pairwise model is actually a statistically consistent model with the observed first and second moments of the stocks orientation without making such restrictive assumptions. This is done with an approach only based on empirical data of price returns. Our data analysis of six major indices suggests that the actual interaction structure may be thought as an Ising model on a complex network with interaction strengths scaling as the inverse of the system size. This has potentially important implications since many properties of such a model are already known and some techniques of the spin glass theory can be straightforwardly applied. Typical behaviors, as multiple equilibria or metastable states, different characteristic time scales, spatial patterns, order-disorder, could find an explanation in this picture.

  8. Design and analysis of electricity markets

    NASA Astrophysics Data System (ADS)

    Sioshansi, Ramteen Mehr

    Restructured competitive electricity markets rely on designing market-based mechanisms which can efficiently coordinate the power system and minimize the exercise of market power. This dissertation is a series of essays which develop and analyze models of restructured electricity markets. Chapter 2 studies the incentive properties of a co-optimized market for energy and reserves that pays reserved generators their implied opportunity cost---which is the difference between their stated energy cost and the market-clearing price for energy. By analyzing the market as a competitive direct revelation mechanism we examine the properties of efficient equilibria and demonstrate that generators have incentives to shade their stated costs below actual costs. We further demonstrate that the expected energy payments of our mechanism is less than that in a disjoint market for energy only. Chapter 3 is an empirical validation of a supply function equilibrium (SFE) model. By comparing theoretically optimal supply functions and actual generation offers into the Texas spot balancing market, we show the SFE to fit the actual behavior of the largest generators in market. This not only serves to validate the model, but also demonstrates the extent to which firms exercise market power. Chapters 4 and 5 examine equity, incentive, and efficiency issues in the design of non-convex commitment auctions. We demonstrate that different near-optimal solutions to a central unit commitment problem which have similar-sized optimality gaps will generally yield vastly different energy prices and payoffs to individual generators. Although solving the mixed integer program to optimality will overcome such issues, we show that this relies on achieving optimality of the commitment---which may not be tractable for large-scale problems within the allotted timeframe. We then simulate and compare a competitive benchmark for a market with centralized and self commitment in order to bound the efficiency

  9. The Chilean Teacher Labor Market

    ERIC Educational Resources Information Center

    Rivero, Maria del Rosario

    2013-01-01

    In Chile, as many other countries, understanding how high-qualified teachers are distributed across schools and which are the relationships that may lead to teachers' potential sorting are key aspect of the teacher labor market and it is central to addressing student achievement gaps. The first paper uses rich new data on all elementary public…

  10. Hospital mergers and market overlap.

    PubMed Central

    Brooks, G R; Jones, V G

    1997-01-01

    OBJECTIVE: To address two questions: What are the characteristics of hospitals that affect the likelihood of their being involved in a merger? What characteristics of particular pairs of hospitals affect the likelihood of the pair engaging in a merger? DATA SOURCES/STUDY SETTING: Hospitals in the 12 county region surrounding the San Francisco Bay during the period 1983 to 1992 were the focus of the study. Data were drawn from secondary sources, including the Lexis/Nexis database, the American Hospital Association, and the Office of Statewide Health Planning and Development of the State of California. STUDY DESIGN: Seventeen hospital mergers during the study period were identified. A random sample of pairs of hospitals that did not merge was drawn to establish a statistically efficient control set. Models constructed from hypotheses regarding hospital and market characteristics believed to be related to merger likelihood were tested using logistic regression analysis. DATA COLLECTION: See Data Sources/Study Setting. PRINCIPAL FINDINGS: The analysis shows that the likelihood of a merger between a particular pair of hospitals is positively related to the degree of market overlap that exists between them. Furthermore, market overlap and performance difference interact in their effect on merger likelihood. In an analysis of individual hospitals, conditions of rivalry, hospital market share, and hospital size were not found to influence the likelihood that a hospital will engage in a merger. CONCLUSIONS: Mergers between hospitals are not driven directly by considerations of market power or efficiency as much as by the existence of specific merger opportunities in the hospitals' local markets. Market overlap is a condition that enables a merger to occur, but other factors, such as the relative performance levels of the hospitals in question and their ownership and teaching status, also play a role in influencing the likelihood that a merger will in fact take place. PMID

  11. Positive Steps for Marketing Higher Education.

    ERIC Educational Resources Information Center

    Fram, Eugene H.

    The potential value of marketing principles to help solve educational problems in higher education is addressed. Four variables that are within the decision power of those in higher education and those in the commercial world are the product, distribution, promotion, and price. The marketing concept demands that policies be built on a base of…

  12. A Marketing Strategy for Spanish for Business.

    ERIC Educational Resources Information Center

    Grosse, Christine Uber

    The development of a marketing strategy for business Spanish courses by means of situational analysis is described. The planner of marketing strategy must consider demand for a course, institutional acceptance, and financial support. A survey of 508 universities revealed a low level of demand for business Spanish which could potentially be…

  13. Intradepartmental Faculty Mentoring in Teaching Marketing

    ERIC Educational Resources Information Center

    Tahtinen, Jaana; Mainela, Tuija; Natti, Satu; Saraniemi, Saila

    2012-01-01

    This study focuses on the use of mentoring by a peer as a way to help teachers of marketing to develop their teaching skills. Using self-ethnography, we elaborate on the potential of intradepartmental faculty mentoring in teaching (FMIT) to enhance the quality of marketing education. The study describes FMIT, a novel type of mentoring, reviews its…

  14. Biogas and Hydrogen Systems Market Assessment

    SciTech Connect

    Milbrandt, Anelia; Bush, Brian; Melaina, Marc

    2016-03-31

    This analysis provides an overview of the market for biogas-derived hydrogen and its use in transportation applications. It examines the current hydrogen production technologies from biogas, capacity and production, infrastructure, potential and demand, as well as key market areas. It also estimates the production cost of hydrogen from biogas and provides supply curves at a national level and at point source.

  15. Veterinary practice marketeer.

    PubMed

    Phillips, Justin

    2015-01-24

    Justin Phillips is marketing manager at White Cross Vets and the Veterinary Marketing Association's (VMA's) Young Veterinary Marketeer of the Year. Here, he describes what he does and why he believes other practices should embrace marketing to improve their quality and client care.

  16. Cooperative Market Research Project.

    ERIC Educational Resources Information Center

    Carels, Peter; McCullough, Lynette

    A pilot project was developed in which the Advertising and Market Research Center of the Vienna School of Economics and Business in Austria and the German Department as well as the Marketing Department of Miami University in Ohio are working together to collect market research data and formulate a market entry strategy for Roemerquelle, an…

  17. Markets for recovered aluminum

    SciTech Connect

    Not Available

    1993-04-01

    The study describes the operation of the markets for scrap aluminum as an example of how recycling markets are structured, what factors influence the supply of and demand for materials, what projections can be made about recycling markets, and how government policies to increase recycling may affect these markets.

  18. Market review - Market values summary/August market review/current market data

    SciTech Connect

    1995-09-01

    This article is the August 1995 uranium market review. During this reporting period, there were three transactions in the long-term concentrates sector, no transactions in the UF6 market, and limited activity in the spot conversion market and the enrichment services market. Active supply rose, as did active demand. Prices were stable to slightly increasing.

  19. Marketing Human Resource Development.

    ERIC Educational Resources Information Center

    Frank, Eric, Ed.

    1994-01-01

    Describes three human resource development activities: training, education, and development. Explains marketing from the practitioners's viewpoint in terms of customer orientation; external and internal marketing; and market analysis, research, strategy, and mix. Shows how to design, develop, and implement strategic marketing plans and identify…

  20. Hospital marketing revisited.

    PubMed

    Costello, M M

    1987-05-01

    With more hospitals embracing the marketing function in their organizational management over the past decade, hospital marketing can no longer be considered a fad. However, a review of hospital marketing efforts as reported in the professional literature indicates that hospitals must pay greater attention to the marketing mix elements of service, price and distribution channels as their programs mature.