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Sample records for potential toxicological hazard

  1. Potential toxicological hazard due to endocrine-disrupting chemicals on Mediterranean top predators: State of art, gender differences and methodological tools

    SciTech Connect

    Fossi, M.C. . E-mail: fossi@unisi.it; Casini, S.; Marsili, L.

    2007-05-15

    Man-made endocrine-disrupting chemicals (EDCs) range across all continents and oceans. Some geographic areas are potentially more threatened than others: one of these is the Mediterranean Sea. Levels of some xenobiotics are much higher here than in other seas and oceans. In this paper we review the final results of a project supported by the Italian Ministry of the Environment, in which the hypothesis that Mediterranean top predator species (such as large pelagic fish and marine mammals) are potentially at risk due to EDCs was investigated. We illustrate the need to develop and apply sensitive methodological tools, such as biomarkers (Vitellogenin, Zona Radiata proteins and CYP1A activities) for evaluation of toxicological risk in large pelagic fish top predators (Swordfish (Xiphias gladius), Bluefin Tuna (Thunnus thynnus thynnus)) and nondestructive biomarkers (CYP1A activities and fibroblast cell culture in skin biopsy), for the hazard assessment of threatened marine mammals species (Striped Dolphin, (Stenella coeruleoalba), Bottlenose Dolphin (Tursiops truncatus), Common Dolphin (Delphinus delphis) and Fin Whale (Balaenoptera physalus))exposed to EDCs. Differential gender susceptibility to EDCs is also explored both in large pelagic fish and in cetaceans. In cetaceans, male specimens showed higher cytochrome P450 induction (BPMO in skyn biopsies, CYP2B in fibroblasts cell cultures) by xenobiotics with respect to females.

  2. Potential toxicological hazard due to endocrine-disrupting chemicals on Mediterranean top predators: state of art, gender differences and methodological tools.

    PubMed

    Fossi, M C; Casini, S; Marsili, L

    2007-05-01

    Man-made endocrine-disrupting chemicals (EDCs) range across all continents and oceans. Some geographic areas are potentially more threatened than others: one of these is the Mediterranean Sea. Levels of some xenobiotics are much higher here than in other seas and oceans. In this paper we review the final results of a project supported by the Italian Ministry of the Environment, in which the hypothesis that Mediterranean top predator species (such as large pelagic fish and marine mammals) are potentially at risk due to EDCs was investigated. We illustrate the need to develop and apply sensitive methodological tools, such as biomarkers (Vitellogenin, Zona Radiata proteins and CYP1A activities) for evaluation of toxicological risk in large pelagic fish top predators (Swordfish, (Xiphias gladius), Bluefin Tuna (Thunnus thynnus thynnus)) and nondestructive biomarkers (CYP1A activities and fibroblast cell culture in skin biopsy), for the hazard assessment of threatened marine mammals species (Striped Dolphin, (Stenella coeruleoalba), Bottlenose Dolphin (Tursiops truncatus), Common Dolphin (Delphinus delphis) and Fin Whale (Balaenoptera physalus))exposed to EDCs. Differential gender susceptibility to EDCs is also explored both in large pelagic fish and in cetaceans. In cetaceans, male specimens showed higher cytochrome P450 induction (BPMO in skyn biopsies, CYP2B in fibroblasts cell cultures) by xenobiotics with respect to females.

  3. Hazard identification by methods of animal-based toxicology.

    PubMed

    Barlow, S M; Greig, J B; Bridges, J W; Carere, A; Carpy, A J M; Galli, C L; Kleiner, J; Knudsen, I; Koëter, H B W M; Levy, L S; Madsen, C; Mayer, S; Narbonne, J-F; Pfannkuch, F; Prodanchuk, M G; Smith, M R; Steinberg, P

    2002-01-01

    This paper is one of several prepared under the project "Food Safety In Europe: Risk Assessment of Chemicals in Food and Diet" (FOSIE), a European Commission Concerted Action Programme, organised by the International Life Sciences Institute, Europe (ILSI). The aim of the FOSIE project is to review the current state of the science of risk assessment of chemicals in food and diet, by consideration of the four stages of risk assessment, that is, hazard identification, hazard characterisation, exposure assessment and risk characterisation. The contribution of animal-based methods in toxicology to hazard identification of chemicals in food and diet is discussed. The importance of first applying existing technical and chemical knowledge to the design of safety testing programs for food chemicals is emphasised. There is consideration of the presently available and commonly used toxicity testing approaches and methodologies, including acute and repeated dose toxicity, reproductive and developmental toxicity, neurotoxicity, genotoxicity, carcinogenicity, immunotoxicity and food allergy. They are considered from the perspective of whether they are appropriate for assessing food chemicals and whether they are adequate to detect currently known or anticipated hazards from food. Gaps in knowledge and future research needs are identified; research on these could lead to improvements in the methods of hazard identification for food chemicals. The potential impact of some emerging techniques and toxicological issues on hazard identification for food chemicals, such as new measurement techniques, the use of transgenic animals, assessment of hormone balance and the possibilities for conducting studies in which common human diseases have been modelled, is also considered.

  4. [Analysis and toxicological evaluation of hazardous gases in sealed cabin].

    PubMed

    He, Z; Shi, J; Yu, B; Liang, H; Yu, F

    1998-10-01

    82 volatile organic compounds (VOCs) of eight organic sorts and 3 target inorganic compounds in a sealed cabin that simulating the flying spaceship were identified and quantified for 5 d, the law of hazardous gas concentration variation was discussed, and the atmosphere toxicology was evaluated preliminarily. It provides a basis for detecting gas compounds and evaluating the atmosphere toxicology in the spaceship.

  5. The toxicologic hazard of superfund hazardous-waste sites.

    PubMed

    Johnson, B L; DeRosa, C

    1997-01-01

    Uncontrolled hazardous-waste sites are a major environmental and public health concern in the United States and elsewhere. The remediation of and public health responses to these sites is mandated by the federal Superfund statute. Approximately 40,000 uncontrolled waste sites have been reported to U.S. federal agencies. About 1,300 of these sites constitute the current National Priorities List (NPL) of sites for remediation. Findings from a national database on NPL sites show approximately 40% present completed exposure pathways, although this figure rose to 80% in 1996. Data from 1992 through 1996 indicate that 46% of sites are a hazard to public health. Thirty substances are found at 6% or more of sites with completed pathways. Eighteen of the substances are known human carcinogens or reasonably anticipated to be carcinogenic. Many of the 30 substances also possess systemic toxicity. The high percentage of sites with completed exposure pathways and the toxicity potential of substances in these pathways show that uncontrolled hazardous-waste sites are a major environmental threat to human health. Findings from the United States' experience in responding to uncontrolled waste sites are relevant to other countries as they address similar environmental and public health concerns.

  6. Characterization of the toxicological hazards of hydrocarbon solvents.

    PubMed

    Mckee, Richard H; Adenuga, M David; Carrillo, Juan-Carlos

    2015-04-01

    Hydrocarbon solvents are liquid hydrocarbon fractions derived from petroleum processing streams, containing only carbon and hydrogen atoms, with carbon numbers ranging from approximately C5-C20 and boiling between approximately 35-370°C. Many of the hydrocarbon solvents have complex and variable compositions with constituents of 4 types, alkanes (normal paraffins, isoparaffins, and cycloparaffins) and aromatics (primarily alkylated one- and two-ring species). Because of the compositional complexity, hydrocarbon solvents are now identified by a nomenclature ("the naming convention") that describes them in terms of physical/chemical properties and compositional elements. Despite the compositional complexity, most hydrocarbon solvent constituents have similar toxicological properties, and the overall toxicological hazards can be characterized in generic terms. To facilitate hazard characterization, the solvents were divided into 9 groups (categories) of substances with similar physical and chemical properties. Hydrocarbon solvents can cause chemical pneumonitis if aspirated into the lung, and those that are volatile can cause acute CNS effects and/or ocular and respiratory irritation at exposure levels exceeding occupational recommendations. Otherwise, there are few toxicologically important effects. The exceptions, n-hexane and naphthalene, have unique toxicological properties, and those solvents containing constituents for which classification is required under the Globally Harmonized System (GHS) are differentiated by the substance names. Toxicological information from studies of representative substances was used to fulfill REACH registration requirements and to satisfy the needs of the OECD High Production Volume (HPV) initiative. As shown in the examples provided, the hazard characterization data can be used for hazard classification and for occupational exposure limit recommendations.

  7. California's potential volcanic hazards

    SciTech Connect

    Jorgenson, P. )

    1989-01-01

    Although volcanic eruptions have occurred infrequently in California during the last few thousand years, the potential danger to life and property from volcanoes in the state is great enough to be of concern, according to a recent U.S. Geological Survey (USGS) publication. The 17-page bulletin, Potential Hazards from Future Volcanic Eruptions in California, gives a brief history of volcanic activity in California during the past 100,000 years, descriptions of the types of volcanoes in the state, the types of potentially hazardous volcanic events that could occur, and hazard-zonation maps and tables depicting six areas of the state where volcanic eruptions might occur. The six areas and brief descriptions of their past volcanic history and potential for future volcanic hazards are briefly summarized here.

  8. Oleoresin Capsicum toxicology evaluation and hazard review

    SciTech Connect

    Archuleta, M.M.

    1995-10-01

    Oleoresin Capsicum (OC) is an extract of the pepper plant used for centuries as a culinary spice (hot peppers). This material has been identified as a safe and effective Less-Than- Lethal weapon for use by Law enforcement and security professionals against assault. The National Institute of Justice (NIJ) is currently also evaluating its use in conjunction with other Less-Than-Lethal agents such as aqueous foam for use in corrections applications. Therefore, a comprehensive toxicological review of the literature was performed for the National Institute of Justice Less-Than-Lethal Force program to review and update the information available on the toxicity and adverse health effects associated with OC exposure. The results of this evaluation indicate that exposure to OC can result in dermatitis, as well as adverse nasal, pulmonary, and gastrointestinal effects in humans. The primary effects of OC exposure include pain and irritation of the mucous membranes of the eyes, nose, and lining of the mouth. Blistering and rash have been shown to occur after chronic or prolonged dermal exposure. Ingestion of capsicum may cause acute stinging of the lips, tongue, and oral mucosa and may lead to vomiting and diarrhea with large doses. OC vapors may also cause significant pulmonary irritation and prolonged cough. There is no evidence of long term effects associated with an acute exposure to OC, and extensive use as a culinary additive and medicinal ointment has further provided no evidence of long term adverse effects following repeated or prolonged exposure.

  9. California's potential volcanic hazards

    USGS Publications Warehouse

    Jorgenson, P.

    1989-01-01

    This is a summary of "Potential Hazards from Future Volcanic Eruptions in California' (USGS Bulletin No. 1847: price $4.75). The chief areas of danger are Lassen Peak, Mount Shasta and Medicine Lake Highland in the north; Clear Lake, Mono Lake and Long Valley in the centre; and Owen's River-Death Valley, Amboy Crater and the Saltan Butter in the south of the State. -A.Scarth

  10. Toxicology primer: understanding workplace hazards and protecting worker health.

    PubMed

    Arble, Janice

    2004-06-01

    Hazardous substances are ubiquitous in the environment and common in industrialized societies. Serious harm can occur with sufficient exposures under certain conditions. However, much harm can be avoided if hazardous substances are handled with respect and appreciation for their use and potential. Occupational health nurses must be aware of potential hazards to employees in the work environment and apply scientific principles to their practice of promoting worker safety and health.

  11. National Toxicology Program

    MedlinePlus

    ... toxicological information about potentially hazardous substances in our environment. NTP strives to remain at the cutting edge of scientific research and the development and application of new technologies for modern toxicology ...

  12. Comparative toxicology of laboratory organisms for assessing hazardous waste sites

    SciTech Connect

    Miller, W.E.; Peterson, S.A.; Greene, J.C.; Callahan, C.A.

    1985-01-01

    Multi-media/multi-trophic level bioassays have been proposed to determine the extent and severity of environmental contamination at hazardous waste sites. Comparative toxicological profiles for algae (Selenastrum capricornutum), daphnia (Daphnia magna), earthworms (Eisenia foetida), microbes (Photobacterium fisherii, mixed sewage microorganisms) and plants; wheat Stephens, (Triticum aestivum), lettuce, butter crunch, (Lactuca sativa L.) radish, Cherry Belle, (Raphanus sativa L.), red clover, Kenland, (Trifolium pratense L.) and cucumber, Spartan Valor, (Cucumis sativa L.) are presented for selected heavy metals, herbicides and insecticides. Specific chemical EC/sub 50/ values are presented for each test organism. Differences in standard deviations were compared between each individual test organism, as well as for the chemical subgroup assayed. Algae and daphnia are the most sensitive test organisms to heavy metals and insecticides followed in order of decreasing sensitivity by Microtox (Photobacterium fisherii), DO depletion rate, seed germination and earthworms. Higher plants were most sensitive to 2,4-D, (2,4-Dichlorophenoxy acetic acid) followed by algae, Microtox, daphnia and earthworms. Differences in toxicity of 2,4-D chemical formulations and commercial sources of insecticides were observed with algae and daphia tests.

  13. Noble metals: a toxicological appraisal of potential new environmental contaminants.

    PubMed Central

    Brubaker, P E; Moran, J P; Bridbord, K; Hueter, F G

    1975-01-01

    The public health benefits expected by reducing known hazardous emissions from mobile sources should not be compromised by increasing levels of other potentially hazardous unregulated emissions. Catalytic converters are going to be used to meet the statutory requirements on carbon monoxide and hydrocarbon emissions from light duty motor vehicles. Platinum and palladium metals are the catalytic materials to be used in these emission control devices. Preliminary experimental evidence and analysis of the impact of these control devices on the future use and demand for platinum indicates that this metal may appear at detectable levels in the environment by the end of this decade. At the present time, platinum and palladium are not present in the public environment and represent potentially new environmental contaminants as a consequence of use of this new abatement control technology. There is relatively little information available to adequately assess the potential health hazards that may be associated with exposure to these metals and their compounds. Analysis of the environmental problems and concerns associated with possible new environmental contaminants are discussed. Limited estimates are made on community exposure by use of a meteorological dispersion model. Biodegradation potential and attention is also given to the limited toxicological information available. PMID:50939

  14. The hazard evaluation system and information service: a physician's resource in toxicology and occupational medicine.

    PubMed

    Hooper, K

    1982-12-01

    Hazard evaluation is an emerging science. The Hazard Evaluation System and Information Service (HESIS), part of California's program in preventive occupational health, is a resource for clinicians who wish to stay abreast of the relationship between toxicology and occupational health. For example, advances in assays for cancer or reproductive effects in test animals enable us to identify with greater confidence significant cancer or reproductive hazards among the increasing variety of workplace exposures. Occupational experiences with dibromochloropropane (DBCP), Kepone, bis(chloromethyl) ether, benzidine and vinyl chloride demonstrate the shortcomings of relying on human data. The latency period of cancer, limited sensitivity of epidemiologic studies and severity of effects require us to use animal test data to evaluate the potential cancer and reproductive risks of workplace substances. HESIS gives appropriate weight to experimental data in hazard evaluations of chemicals such as ethylene oxide, ethylene dibromide, polychlorinated biphenyls and the glycol ethers. A similar approach is apparent in the California Department of Health Services' recently released Carcinogen Identification Policy.

  15. The Hazard Evaluation System and Information Service: A Physician's Resource in Toxicology and Occupational Medicine

    PubMed Central

    Hooper, Kim

    1982-01-01

    Hazard evaluation is an emerging science. The Hazard Evaluation System and Information Service (HESIS), part of California's program in preventive occupational health, is a resource for clinicians who wish to stay abreast of the relationship between toxicology and occupational health. For example, advances in assays for cancer or reproductive effects in test animals enable us to identify with greater confidence significant cancer or reproductive hazards among the increasing variety of workplace exposures. Occupational experiences with dibromochloropropane (DBCP), Kepone, bis(chloromethyl) ether, benzidine and vinyl chloride demonstrate the shortcomings of relying on human data. The latency period of cancer, limited sensitivity of epidemiologic studies and severity of effects require us to use animal test data to evaluate the potential cancer and reproductive risks of workplace substances. HESIS gives appropriate weight to experimental data in hazard evaluations of chemicals such as ethylene oxide, ethylene dibromide, polychlorinated biphenyls and the glycol ethers. A similar approach is apparent in the California Department of Health Services' recently released Carcinogen Identification Policy. PMID:6819719

  16. Scoring of solvents used in analytical laboratories by their toxicological and exposure hazards.

    PubMed

    Tobiszewski, Marek; Namieśnik, Jacek

    2015-10-01

    Green analytical chemistry, although a well recognised concept, still lacks reliable environmental impact assessment procedures. This article describes scoring of solvents, frequently used in analytical laboratories, with CHEMS-1 model. The model uses toxicological and exposure data to calculate hazard values related to the utilisation of solvents. The original model was modified to incorporate hazards related to the volatility of chemicals. The scoring of hazard values showed that polar solvents are less hazardous. The scoring results were applied to assess the total hazard values in terms of solvent consumption. The hazard scores calculated for each chemical were multiplied by the volumes of solvent used during the analytical procedure. The results show that calculation of total procedural hazard values is valuable in the green analytical chemistry assessment procedure. Moreover, the assessment procedure can be combined with other procedural greenness assessment methods. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. It is time to develop ecological thresholds of toxicological concern to assist environmental hazard assessment.

    PubMed

    Belanger, Scott E; Sanderson, Hans; Embry, Michelle R; Coady, Katie; DeZwart, Dick; Farr, Brianna A; Gutsell, Steve; Halder, Marlies; Sternberg, Robin; Wilson, Peter

    2015-12-01

    The threshold of toxicological concern (TTC) concept is well established for assessing human safety of food-contact substances and has been reapplied for a variety of endpoints, including carcinogenicity, teratogenicity, and reproductive toxicity. The TTC establishes an exposure level for chemicals below which no appreciable risk to human health or the environment is expected, based on a de minimis value for toxicity identified for many chemicals. Threshold of toxicological concern approaches have benefits for screening-level risk assessments, including the potential for rapid decision-making, fully utilizing existing knowledge, reasonable conservativeness for chemicals used in lower volumes (low production volume chemicals (e.g., < 1 t/yr), and reduction or elimination of unnecessary animal tests. Higher production volume chemicals (>1 t/yr) would in principle always require specific information because of the presumed higher exposure potential. The TTC approach has found particular favor in the assessment of chemicals used in cosmetics and personal care products, as well as other chemicals traditionally used in low volumes. Use of the TTC in environmental safety is just beginning, and initial attempts are being published. Key questions focus on hazard extrapolation of diverse taxa across trophic levels, importance of mode of action, and whether safe concentrations for ecosystems estimated from acute or chronic toxicity data are equally useful and in what contexts. The present study provides an overview of the theoretical basis for developing an ecological (eco)-TTC, with an initial exploration of chemical assessment and boundary conditions for use. An international collaboration under the International Life Sciences Institute Health and Environmental Sciences Institute has been established to address challenges related to developing and applying useful eco-TTC concepts. © 2015 SETAC.

  18. Databases applicable to quantitative hazard/risk assessment-Towards a predictive systems toxicology

    SciTech Connect

    Waters, Michael Jackson, Marcus

    2008-11-15

    The Workshop on The Power of Aggregated Toxicity Data addressed the requirement for distributed databases to support quantitative hazard and risk assessment. The authors have conceived and constructed with federal support several databases that have been used in hazard identification and risk assessment. The first of these databases, the EPA Gene-Tox Database was developed for the EPA Office of Toxic Substances by the Oak Ridge National Laboratory, and is currently hosted by the National Library of Medicine. This public resource is based on the collaborative evaluation, by government, academia, and industry, of short-term tests for the detection of mutagens and presumptive carcinogens. The two-phased evaluation process resulted in more than 50 peer-reviewed publications on test system performance and a qualitative database on thousands of chemicals. Subsequently, the graphic and quantitative EPA/IARC Genetic Activity Profile (GAP) Database was developed in collaboration with the International Agency for Research on Cancer (IARC). A chemical database driven by consideration of the lowest effective dose, GAP has served IARC for many years in support of hazard classification of potential human carcinogens. The Toxicological Activity Profile (TAP) prototype database was patterned after GAP and utilized acute, subchronic, and chronic data from the Office of Air Quality Planning and Standards. TAP demonstrated the flexibility of the GAP format for air toxics, water pollutants and other environmental agents. The GAP format was also applied to developmental toxicants and was modified to represent quantitative results from the rodent carcinogen bioassay. More recently, the authors have constructed: 1) the NIEHS Genetic Alterations in Cancer (GAC) Database which quantifies specific mutations found in cancers induced by environmental agents, and 2) the NIEHS Chemical Effects in Biological Systems (CEBS) Knowledgebase that integrates genomic and other biological data including

  19. Determining acute health hazard ratings in the absence of applicable toxicological data.

    PubMed

    Simmons, Fred; Quigley, David; Freshwater, Dave; Whyte, Helena; Boada-Clista, Lydia; Laul, J C

    2007-11-01

    Health, safety, and emergency planning professionals have a responsibility to identify acute hazards associated with chemicals and to find a way to transmit that information to chemical users, emergency responders, and others. Various organizations such as the Department of Energy are considering acute health hazard ratings as triggers that would mandate various activities. A paradigm shift away from a "lists" based approach to determining whether a chemical is sufficiently hazardous to require further analysis for emergency planning purposes is under way. Various toxicological data sources and approaches in use to develop an acute health hazard rating are discussed. Methods of extrapolating data from published and unpublished supporting documentation to develop an acute health hazard rating in the absence of toxicological data by animal species, chemical structure similarities, MSDS estimated values, and data mining are discussed. The process described analyzes applicable data and allows the analyst to determine reasonable health hazard rating numbers for chemicals without published hazard ratings and for mixtures of chemicals. The level and amount of resources available will determine which methods will be used in the process.

  20. Identification of Potential Hazard using Hazard Identification and Risk Assessment

    NASA Astrophysics Data System (ADS)

    Sari, R. M.; Syahputri, K.; Rizkya, I.; Siregar, I.

    2017-03-01

    This research was conducted in the paper production’s company. These Paper products will be used as a cigarette paper. Along in the production’s process, Company provides the machines and equipment that operated by workers. During the operations, all workers may potentially injured. It known as a potential hazard. Hazard identification and risk assessment is one part of a safety and health program in the stage of risk management. This is very important as part of efforts to prevent occupational injuries and diseases resulting from work. This research is experiencing a problem that is not the identification of potential hazards and risks that would be faced by workers during the running production process. The purpose of this study was to identify the potential hazards by using hazard identification and risk assessment methods. Risk assessment is done using severity criteria and the probability of an accident. According to the research there are 23 potential hazard that occurs with varying severity and probability. Then made the determination Risk Assessment Code (RAC) for each potential hazard, and gained 3 extreme risks, 10 high risks, 6 medium risks and 3 low risks. We have successfully identified potential hazard using RAC.

  1. Toxicological hazard induced by sucralose to environmentally relevant concentrations in common carp (Cyprinus carpio).

    PubMed

    Saucedo-Vence, Karinne; Elizalde-Velázquez, Armando; Dublán-García, Octavio; Galar-Martínez, Marcela; Islas-Flores, Hariz; SanJuan-Reyes, Nely; García-Medina, Sandra; Hernández-Navarro, María Dolores; Gómez-Oliván, Leobardo Manuel

    2017-01-01

    Sucralose (SUC) is an artificial sweetener that is now widely used in North American and Europe; it has been detected in a wide variety of aquatic environments. It is considered safe for human consumption but its effects in the ecosystem have not yet been studied in depth, since limited ecotoxicological data are available in the peer-reviewed literature. This study aimed to evaluate potential SUC-induced toxicological hazard in the blood, brain, gill, liver and muscle of Cyprinus carpio using oxidative stress biomarkers. Carps were exposed to two different environmentally relevant concentrations (0.05 and 155μgL(-1)) for different exposure times (12, 24, 48, 72 and 96h). The following biomarkers were evaluated: lipid peroxidation (LPX), hydroperoxide content (HPC) and protein carbonyl content (PCC), as well as the activity of antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT). SUC was determined by high pressure liquid chromatography tandem mass spectrometry techniques (HPLC)-MS/MS. Results show a statically significant increase in LPX, HPC, PCC (P<0.05) especially in gill, brain and muscle, as well as significant changes in the activity of antioxidant enzymes in gill and muscle. Furthermore, the biomarkers employed in this study are useful in the assessment of the environmental impact of this agent on aquatic species. Copyright © 2016 Elsevier B.V. All rights reserved.

  2. Downloadable Computational Toxicology Data

    EPA Pesticide Factsheets

    EPA’s computational toxicology research generates data that investigates the potential harm, or hazard of a chemical, the degree of exposure to chemicals as well as the unique chemical characteristics. This data is publicly available here.

  3. Radon-hazard potential of Utah

    SciTech Connect

    Black, B.D.; Solomon, B.J. )

    1993-04-01

    Radon is a naturally occurring radioactive gas formed by decay of uranium, and occurs in nearly all geologic materials. Although radon has been shown to be a significant cause of lung cancer in miners, the health hazard from accumulation of radon gas in buildings has only recently been recognized. Indoor-radon hazards depend on both geologic and non-geologic factors. Although non-geologic factors such as construction type, weather, and lifestyles are difficult to measure, geologic factors such as uranium concentration, soil permeability, and depth to ground water can be quantified. Uranium-enriched geologic materials, such as black shales, marine sandstones, and certain granitic, metamorphic, and volcanic rocks, are generally associated with a high radon-hazard potential. Impermeable soil or shallow ground water impedes radon movement and is generally associated with a low radon-hazard potential. A numerical rating system based on these geologic factors has been developed to map radon-hazard potential in Utah. A statewide map shows that the radon-hazard potential of Utah is generally moderate. Assessments of hazard potential from detailed field investigations correlate well with areas of this map. Central Utah has the highest radon-hazard potential, primarily due to uranium-enriched Tertiary volcanic rocks. The radon-hazard potential of eastern Utah is moderate to high, but is generally restricted by low uranium levels. Western Utah, where valley basins with impermeable soils and shallow ground water are common, has the lowest radon-hazard potential.

  4. Genetic toxicology at the crossroads-from qualitative hazard evaluation to quantitative risk assessment.

    PubMed

    White, Paul A; Johnson, George E

    2016-05-01

    Applied genetic toxicology is undergoing a transition from qualitative hazard identification to quantitative dose-response analysis and risk assessment. To facilitate this change, the Health and Environmental Sciences Institute (HESI) Genetic Toxicology Technical Committee (GTTC) sponsored a workshop held in Lancaster, UK on July 10-11, 2014. The event included invited speakers from several institutions and the contents was divided into three themes-1: Point-of-departure Metrics for Quantitative Dose-Response Analysis in Genetic Toxicology; 2: Measurement and Estimation of Exposures for Better Extrapolation to Humans and 3: The Use of Quantitative Approaches in Genetic Toxicology for human health risk assessment (HHRA). A host of pertinent issues were discussed relating to the use of in vitro and in vivo dose-response data, the development of methods for in vitro to in vivo extrapolation and approaches to use in vivo dose-response data to determine human exposure limits for regulatory evaluations and decision-making. This Special Issue, which was inspired by the workshop, contains a series of papers that collectively address topics related to the aforementioned themes. The Issue includes contributions that collectively evaluate, describe and discuss in silico, in vitro, in vivo and statistical approaches that are facilitating the shift from qualitative hazard evaluation to quantitative risk assessment. The use and application of the benchmark dose approach was a central theme in many of the workshop presentations and discussions, and the Special Issue includes several contributions that outline novel applications for the analysis and interpretation of genetic toxicity data. Although the contents of the Special Issue constitutes an important step towards the adoption of quantitative methods for regulatory assessment of genetic toxicity, formal acceptance of quantitative methods for HHRA and regulatory decision-making will require consensus regarding the

  5. Toxicology and clinical potential of nanoparticles

    PubMed Central

    Yildirimer, Lara; Thanh, Nguyen T.K.; Loizidou, Marilena; Seifalian, Alexander M.

    2011-01-01

    Summary In recent years, nanoparticles (NPs) have increasingly found practical applications in technology, research and medicine. The small particle size coupled to their unique chemical and physical properties is thought to underlie their exploitable biomedical activities. Here, we review current toxicity studies of NPs with clinical potential. Mechanisms of cytotoxicity are discussed and the problem of extrapolating knowledge gained from cell-based studies into a human scenario is highlighted. The so-called ‘proof-of-principle’ approach, whereby ultra-high NP concentrations are used to ensure cytotoxicity, is evaluated on the basis of two considerations; firstly, from a scientific perspective, the concentrations used are in no way related to the actual doses required which, in many instances, discourages further vital investigations. Secondly, these inaccurate results cast doubt on the science of nanomedicine and thus, quite dangerously, encourage unnecessary alarm in the public. In this context, the discrepancies between in vitro and in vivo results are described along with the need for a unifying protocol for reliable and realistic toxicity reports. PMID:23293661

  6. Synthetic vitreous fibers: a review of toxicology research and its impact on hazard classification.

    PubMed

    Hesterberg, T W; Hart, G A

    2001-01-01

    Because the inhalation of asbestos, a naturally occurring, inorganic fibrous material, is associated with lung fibrosis and thoracic cancers, concerns have been raised about the possible health effects of synthetic vitreous fibers (SVFs). SVFs include a very broad variety of inorganic fibrous materials with an amorphous molecular structure. Traditionally, SVFs have been divided into three subcategories based on composition: fiberglass, mineral wool (rock, stone, and slag wools), and refractory ceramic fiber. For more than 50 years, the toxicologic potential of SVFs has been researched extensively using human epidemiology and a variety of laboratory studies. Here we review the research and its impact on hazard classification and regulation of SVFs. Large, ongoing epidemiology studies of SVF manufacturing workers have provided very little evidence of harmful effects in humans. Several decades of research using rodents exposed by inhalation have confirmed that SVF pulmonary effects are determined by the "Three D's", fiber dose (lung), dimension, and durability. Lung dose over time is determined by fiber deposition and biopersistence in the lung. Deposition is inversely related to fiber diameter. Biopersistence is directly related to fiber length and inversely related to fiber dissolution and fragmentation rates. Inhaled short fibers are cleared from the lung relatively quickly by mobile phagocytic cells, but long fibers persist until they dissolve or fragment. In contrast to asbestos, most of the SVFs tested in rodent inhalation studies cleared rapidly from the lung (were nonbiopersistent) and were innocuous. However, several relativley biopersistent SVFs induced chronic inflammation, lung scarring (fibrosis), and thoracic neoplasms. Thus, biopersistence of fibers is now generally recognized as a key determinant of the toxicologic potential of SVFs. In vitro dissolution of fibers in simulated extracellular fluid correlates fairly well with fiber biopersistence in the

  7. Potential Hazards of Plastics Used in Sculpture

    ERIC Educational Resources Information Center

    Siedlecke, Jerome T.

    1972-01-01

    This paper discusses the thermoplastic and thermosetting resins presently being used by the artist, and the potential for exposure to the toxic chemicals and other hazards during the development of his creative work. (Author)

  8. Potential Hazards of Plastics Used in Sculpture

    ERIC Educational Resources Information Center

    Siedlecke, Jerome T.

    1972-01-01

    This paper discusses the thermoplastic and thermosetting resins presently being used by the artist, and the potential for exposure to the toxic chemicals and other hazards during the development of his creative work. (Author)

  9. Potential hazards of fumigant residues.

    PubMed Central

    Fishbein, L

    1976-01-01

    A spectrum of fumigants (primarily ethylene dibromide, 1,2-dibromo-3-chloropropane, ethylene oxide, symdibromotetetrachloroethane, 1,3-dichloropropene, dichlorovos, carbon tetrachloride, methyl bromide) as well as their degradation products in foodstuffs and soil have been examined mainly in regard to the potential mutagenicity of their residues. PMID:789068

  10. Comparative toxicology of laboratory organisms for assessing hazardous-waste sites

    SciTech Connect

    Miller, W.E.; Peterson, S.A.; Greene, J.C.; Callahan, C.A.

    1985-01-01

    Multi-media/multi-trophic level bioassays have been proposed to determine the extent and severity of environmental contamination at hazardous waste sites. Comparative toxicological profiles for algae, daphnia, earthworms, microbes, mixed sewage and plants; wheat Stephens, lettuce, butter crunch, radish, Cherry Belle, red clover, Kenland, and cucumber, Spartan Valor are presented for selected heavy metals, herbicides and insecticides. Specific chemical EC50 values are presented for each test organism. Differences in standard deviations were compared between each individual test organism, as well as for the chemical subgroup assayed. Algae and daphnia are the most sensitive test organisms to heavy metals and insecticides followed in order of decreasing sensitivity by Microtox, DO depletion rate, seed germination and earthworms. Differences in toxicity of 2,4-D chemical formulations and commercial sources of insecticides were observed with algae and daphnia tests.

  11. Evaluation of the ToxRTool's ability to rate the reliability of toxicological data for human health hazard assessments

    EPA Science Inventory

    Regulatory agencies often utilize results from peer reviewed publications for hazard assessments.A problem in doing so is the lack of well-accepted tools to objectively, efficiently and systematically assess the quality of published toxicological studies. Herein, we evaluated the...

  12. Evaluation of the ToxRTool's ability to rate the reliability of toxicological data for human health hazard assessments

    EPA Science Inventory

    Regulatory agencies often utilize results from peer reviewed publications for hazard assessments.A problem in doing so is the lack of well-accepted tools to objectively, efficiently and systematically assess the quality of published toxicological studies. Herein, we evaluated the...

  13. Toxicological evaluation for the hazard assessment of tire crumb for use in public playgrounds.

    PubMed

    Birkholz, Detlef A; Belton, Kathy L; Guidotti, Tee L

    2003-07-01

    Disposal of used tires has been a major problem in solid waste management. New uses will have to be found to consume recycled tire products. One such proposed use is as ground cover in playgrounds. However, concern has been expressed regarding exposure of children to hazardous chemicals and the environmental impact of such chemicals. We designed a comprehensive hazard assessment to evaluate and address potential human health and environmental concerns associated with the use of tire crumb in playgrounds. Human health concerns were addressed using conventional hazard analyses, mutagenicity assays, and aquatic toxicity tests of extracted tire crumb. Hazard to children appears to be minimal. Toxicity to all aquatic organisms (bacteria, invertebrates, fish, and green algae) was observed; however, this activity disappeared with aging of the tire crumb for three months in place in the playground. We conclude that the use of tire crumb in playgrounds results in minimal hazard to children and the receiving environment.

  14. Intranasal Chromium Induces Acute Brain and Lung Injuries in Rats: Assessment of Different Potential Hazardous Effects of Environmental and Occupational Exposure to Chromium and Introduction of a Novel Pharmacological and Toxicological Animal Model

    PubMed Central

    Salama, Abeer; Hassan, Azza

    2016-01-01

    Chromium (Cr) is used in many industries and it is widely distributed in the environment. Exposure to Cr dust has been reported among workers at these industries. Beside its hazardous effects on the lungs, brain injury could be induced, as the absorption of substances through the nasal membrane has been found to provide them a direct delivery to the brain. We investigated the distribution and the effects of Cr in both brain and lung following the intranasal instillation of potassium dichromate (inPDC) in rats. Simultaneously, we used the common intraperitoneal (ipPDC) rat model of acute Cr-toxicity for comparison. Thirty male Wistar rats were randomly allocated into five groups (n = 6); each received a single dose of saline, ipPDC (15 mg/kg), or inPDC in three dose levels: 0.5, 1, or 2 mg/kg. Locomotor activity was assessed before and 24 h after PDC administration, then, the lungs and brain were collected for biochemical, histopathological, and immunohistochemical investigations. Treatment of rats with ipPDC resulted in a recognition of 36% and 31% of the injected dose of Cr in the brain and lung tissues, respectively. In inPDC-treated rats, targeting the brain by Cr was increased in a dose-dependent manner to reach 46% of the instilled dose in the group treated with the highest dose. Moreover, only this high dose of inPDC resulted in a delivery of a significant concentration of Cr, which represented 42% of the instilled dose, to the lungs. The uppermost alteration in the rats locomotor activity as well as in the brain and lung histopathological features and contents of oxidative stress biomarkers, interleukin-1β (IL-1β), phosphorylated protein kinase B (PKB), and cyclooxygenase 2 (COX-2) were observed in the rats treated with inPDC (2 mg/kg). The findings revealed that these toxic manifestations were directly proportional to the delivered concentration of Cr to the tissue. In conclusion, the study showed that a comparably higher concentrations of Cr and more

  15. Mercury as a potential hazard for the dental practitioner.

    PubMed

    Kostyniak, P J

    1998-04-01

    Mercury has been used for centuries for medical, chemical, metallurgical and electrical applications. It is an element of mystery, which in its metallic form is an enticing silvery liquid that can be as fascinating as it is dangerous. Its use in dental amalgam has a potential for continuous occupational exposure of dental practitioners to mercury vapor. It is imperative that the dental practitioner understands the hazards associated with the use of mercury, and controls exposures to prevent the development of any untoward effects. This article provides an overview of the toxicology of the different forms of mercury to which human exposure occurs and addresses safety issues associated with mercury vapor, the primary form of mercury encountered in the practice of dentistry.

  16. Toxicological procedures for assessing the carcinogenic potential of agricultural chemicals.

    PubMed

    Krewski, D; Clayson, D; Collins, B; Munro, I C

    1982-01-01

    Pesticides and other agricultural chemicals are now widely used throughout the world as a means of improving crop yields in order to meet the increasing demands being placed upon the global food supply. In Canada, the use of such chemicals is controlled through government regulations established jointly by the Department of Agriculture and the Department of National Health & Welfare. Such regulations require a detailed evaluation of the toxicological characteristics of the chemical prior to its being cleared for use. In this paper, procedures for assessing the carcinogenic potential of agricultural and other chemicals are discussed. Consideration is given to both the classical long-term in vivo carcinogen bioassay in rodent or other species and the more recently developed short-term in vitro tests based on genetic alterations in bacterial and other test systems.

  17. California’s potential volcanic hazards

    USGS Publications Warehouse

    Jorgenson, P.

    1989-01-01

    Although volcanic eruptions have occurred infrequently in California during the last few thousand years, the potential danger to life and property from volcanoes in the state is great enough to be of concern, according to a recent U.S Geological Survey (USGS) publication. the 17-page bulletin, "Potential Hazards from Future Volcanic Eruptions in California," gives a brief history of volcanic activity in California during the past 100,000 years, descriptions of the types of volcanoes in the state, the types of potentially hazardous volcanic events that could occur, and hazard-zonation maps and tables depicting six areas of the state where volcanic eruptions might occur. Although no quantitative probabilities are attached to any of the potential volcanic hazards, the USGS bulletin warns that "sooner or later a volcano in California will erupt again and the ever-expanding use of area near volcnoes increases the potential impact of an eruption on the state's economy and on the health and safety of its citizens. 

  18. [Potential radiation hazard in nuclear medicine].

    PubMed

    Guilabert, Nadine; Ricard, Marcel; Chamoulaud, Karen; Mazelier, Carole; Schlumberger, Martin

    2015-01-01

    Nuclear medicine uses unsealed radioisotopes. The potential radiation hazards depend on the amount of radioactivity administered and the type of radionucleide. Thus, radiation safety instructions will minimize radiation exposure and contamination as low as reasonably achievable. National nuclear safety authority requires rules, regulations and exposure limits for both patients and workers. Good practices and training staff contribute to optimize the radioprotection.

  19. Potential Health Hazards of Video Display Terminals.

    ERIC Educational Resources Information Center

    Murray, William E.; And Others

    In response to a request from three California unions to evaluate potential health hazards from the use of video display terminals (VDT's) in information processing applications, the National Institute for Occupational Safety and Health (NIOSH) conducted a limited field investigation of three companies in the San Francisco-Oakland Bay Area. A…

  20. The pharmacology, toxicology and potential applications of arecoline: a review.

    PubMed

    Liu, Yu-Jie; Peng, Wei; Hu, Mei-Bian; Xu, Min; Wu, Chun-Jie

    2016-11-01

    Arecoline is an effective constituent of Areca catechu L. (Arecaceae) with various pharmacological effects. However, investigations also revealed that long use of arecoline could arouse some oral diseases. The present review gathers the fragmented information available in the literature (before 1 October 2015) regarding pharmacology and toxicology of arecoline. We also discussed the potential developments and applications of arecoline in the future. All the available information regarding the arecoline is compiled from scientific databases, including Science Direct, PubMed, Web of Science, Scopus, etc. Previous research demonstrated that arecoline is one of the major effective constituents in A. catechu. Additionally, arecoline has a wide spectrum of pharmacological activities including effects on nervous, cardiovascular, digestive and endocrine systems and anti-parasitic effects. What's more, arecoline is reported to be the primary toxic constituent of A. catechu, and the main toxic effects include oral submucous fibrosis (OSF), oral squamous cell carcinoma (OSCC) and genotoxicity. Arecoline has great potential to be a therapeutic drug for various ailments. However, further investigations are needed in the future to reduce or eliminate its toxicities before developing into new drug.

  1. Human carcinogenic risk evaluation, Part V: The national toxicology program vision for assessing the human carcinogenic hazard of chemicals.

    PubMed

    Bucher, John R; Portier, Christopher

    2004-12-01

    The National Toxicology Program (NTP) has over 25 years of experience in the design, performance, and interpretation of assays for identifying carcinogenic hazards to humans. Through the years we have examined alternative assays and adjunct assays to the standard rodent cancer bioassay including batteries of genetic toxicity tests and genetically modified mouse models. As our collective understanding of carcinogenesis advances, toxicologists and regulatory scientists will at some point begin to rely on mechanism-based biological observations rather than the two-year rodent bioassay to predict human cancer hazards. The goal of the NTP Vision for the 21st Century is to develop the science base that will advance the use of mechanism-based biological observations, eventually providing a replacement for disease-specific toxicology models in the protection of public health.

  2. Spaceflight Toxicology

    NASA Technical Reports Server (NTRS)

    Meyers, Valerie

    2008-01-01

    This viewgraph presentation provides a review of NASA Johnson Space Center's Toxicology program. The mission of this program is to protect crews from toxic exposures during spaceflight. The presentation reviews some of the health hazards. A toxicological hazard level chart is presented that reviews the rating of hazard level, irritancy, systemic effects and containability. The program also participates in the Lunar Airborne Dust Toxicity Advisory Group.

  3. Development and Application of Computational/In Vitro Toxicological Methods for Chemical Hazard Risk Reduction of New Materials for Advanced Weapon Systems

    NASA Technical Reports Server (NTRS)

    Frazier, John M.; Mattie, D. R.; Hussain, Saber; Pachter, Ruth; Boatz, Jerry; Hawkins, T. W.

    2000-01-01

    The development of quantitative structure-activity relationship (QSAR) is essential for reducing the chemical hazards of new weapon systems. The current collaboration between HEST (toxicology research and testing), MLPJ (computational chemistry) and PRS (computational chemistry, new propellant synthesis) is focusing R&D efforts on basic research goals that will rapidly transition to useful products for propellant development. Computational methods are being investigated that will assist in forecasting cellular toxicological end-points. Models developed from these chemical structure-toxicity relationships are useful for the prediction of the toxicological endpoints of new related compounds. Research is focusing on the evaluation tools to be used for the discovery of such relationships and the development of models of the mechanisms of action. Combinations of computational chemistry techniques, in vitro toxicity methods, and statistical correlations, will be employed to develop and explore potential predictive relationships; results for series of molecular systems that demonstrate the viability of this approach are reported. A number of hydrazine salts have been synthesized for evaluation. Computational chemistry methods are being used to elucidate the mechanism of action of these salts. Toxicity endpoints such as viability (LDH) and changes in enzyme activity (glutahoione peroxidase and catalase) are being experimentally measured as indicators of cellular damage. Extrapolation from computational/in vitro studies to human toxicity, is the ultimate goal. The product of this program will be a predictive tool to assist in the development of new, less toxic propellants.

  4. Development and Application of Computational/In Vitro Toxicological Methods for Chemical Hazard Risk Reduction of New Materials for Advanced Weapon Systems

    NASA Technical Reports Server (NTRS)

    Frazier, John M.; Mattie, D. R.; Hussain, Saber; Pachter, Ruth; Boatz, Jerry; Hawkins, T. W.

    2000-01-01

    The development of quantitative structure-activity relationship (QSAR) is essential for reducing the chemical hazards of new weapon systems. The current collaboration between HEST (toxicology research and testing), MLPJ (computational chemistry) and PRS (computational chemistry, new propellant synthesis) is focusing R&D efforts on basic research goals that will rapidly transition to useful products for propellant development. Computational methods are being investigated that will assist in forecasting cellular toxicological end-points. Models developed from these chemical structure-toxicity relationships are useful for the prediction of the toxicological endpoints of new related compounds. Research is focusing on the evaluation tools to be used for the discovery of such relationships and the development of models of the mechanisms of action. Combinations of computational chemistry techniques, in vitro toxicity methods, and statistical correlations, will be employed to develop and explore potential predictive relationships; results for series of molecular systems that demonstrate the viability of this approach are reported. A number of hydrazine salts have been synthesized for evaluation. Computational chemistry methods are being used to elucidate the mechanism of action of these salts. Toxicity endpoints such as viability (LDH) and changes in enzyme activity (glutahoione peroxidase and catalase) are being experimentally measured as indicators of cellular damage. Extrapolation from computational/in vitro studies to human toxicity, is the ultimate goal. The product of this program will be a predictive tool to assist in the development of new, less toxic propellants.

  5. Information profiles on potential occupational hazards: benzoin

    SciTech Connect

    Not Available

    1981-03-01

    Information on potential occupational hazards from exposure to benzoin was reviewed. Topics discussed included chemical and physical properties, production, uses, manufacturers and distributors, manufacturing processes, occupational exposure, and biological effects. The annual production of benzoin is approximately 90,000 pounds per year with an historical growth rate of about 6% per year. In carcinogenesis studies, the incidence of lymphomas and leukemia in dosed male rats increased with dose level, but not significantly. Mice demonstrated a significant increase in the incidence of lymphomas and leukemias at low dose levels. Bioassays have indicated that benzoin is not carcinogenic to male or female F344-rats or B6C3F1-mice. No evidence of mutagenicity, teratogenicity, or reproductive effects was found in animal studies. Allergic contact dermatitis has been reported in humans.

  6. Toxicological Benchmarks for Screening Potential Contaminants of Concern for Effects on Sediment-Associated Biota

    SciTech Connect

    Hull, R.N.

    1993-01-01

    A hazardous waste site may contain hundreds of chemicals; therefore, it is important to screen contaminants of potential concern for the ecological risk assessment. Often this screening is done as part of a screening assessment, the purpose of which is to evaluate the available data, identify data gaps, and screen contaminants of potential concern. Screening may be accomplished by using a set of toxicological benchmarks. These benchmarks are helpful in determining whether contaminants warrant further assessment or are at a level that requires no further attention. If a chemical concentration or the reported detection limit exceeds a proposed lower benchmark, further analysis is needed to determine the hazards posed by that chemical. If, however, the chemical concentration falls below the lower benchmark value, the chemical may be eliminated from further study. The use of multiple benchmarks is recommended for screening chemicals of concern in sediments. Integrative benchmarks developed for the National Oceanic and Atmospheric Administration and the Florida Department of Environmental Protection are included for inorganic and organic chemicals. Equilibrium partitioning benchmarks are included for screening nonionic organic chemicals. Freshwater sediment effect concentrations developed as part of the U.S. Environmental Protection Agency's (EPA's) Assessment and Remediation of Contaminated Sediment Project are included for inorganic and organic chemicals (EPA 1996). Field survey benchmarks developed for the Ontario Ministry of the Environment are included for inorganic and organic chemicals. In addition, EPA-proposed sediment quality criteria are included along with screening values from EPA Region IV and Ecotox Threshold values from the EPA Office of Solid Waste and Emergency Response. Pore water analysis is recommended for ionic organic compounds; comparisons are then made against water quality benchmarks. This report is an update of three prior reports (Jones et al

  7. Grasping the Nature of Potentially Hazardous Asteroids

    NASA Astrophysics Data System (ADS)

    Perna, D.; Dotto, E.; Ieva, S.; Barucci, M. A.; Bernardi, F.; Fornasier, S.; De Luise, F.; Perozzi, E.; Rossi, A.; Mazzotta Epifani, E.; Micheli, M.; Deshapriya, J. D. P.

    2016-01-01

    Through their delivery of water and organics, near-Earth objects (NEOs) played an important role in the emergence of life on our planet. However, they also pose a hazard to the Earth, as asteroid impacts could significantly affect our civilization. Potentially hazardous asteroids (PHAs) are those that, in principle, could possibly impact the Earth within the next century, producing major damage. About 1600 PHAs are currently known, from an estimated population of 4700 ± 1450. However, a comprehensive characterization of the PHA physical properties is still missing. Here we present spectroscopic observations of 14 PHAs, which we have used to derive their taxonomy, meteorite analogs, and mineralogy. Combining our results with the literature, we investigated how PHAs are distributed as a function of their dynamical and physical properties. In general, the “carbonaceous” PHAs seem to be particularly threatening, because of their high porosity (limiting the effectiveness of the main deflection techniques that could be used in space) and low inclination and minimum orbit intersection distance (MOID) with the Earth (favoring more frequent close approaches). V-type PHAs also present low MOID values, which can produce frequent close approaches (as confirmed by the recent discovery of a limited space weathering on their surfaces). We also identified those specific objects that deserve particular attention because of their extreme rotational properties, internal strength, or possible cometary nature. For PHAs and NEOs in general, we identified a possible anti-correlation between the elongation and the rotational period, in the range of Prot ≈ 5-80 hr. This would be compatible with the behavior of gravity-dominated aggregates in rotational equilibrium. For periods ≳80-90 hr, such a trend stops, possibly under the influence of the YORP effect and collisions. However, the statistics is very low, and further observational and theoretical work is required to characterize

  8. GRASPING THE NATURE OF POTENTIALLY HAZARDOUS ASTEROIDS

    SciTech Connect

    Perna, D.; Barucci, M. A.; Fornasier, S.; Deshapriya, J. D. P.; Dotto, E.; Ieva, S.; Epifani, E. Mazzotta; Bernardi, F.; Luise, F. De; Perozzi, E.; Rossi, A.; Micheli, M.

    2016-01-15

    Through their delivery of water and organics, near-Earth objects (NEOs) played an important role in the emergence of life on our planet.  However, they also pose a hazard to the Earth, as asteroid impacts could significantly affect our civilization. Potentially hazardous asteroids (PHAs) are those that, in principle, could possibly impact the Earth within the next century, producing major damage. About 1600 PHAs are currently known, from an estimated population of 4700 ± 1450. However, a comprehensive characterization of the PHA physical properties is still missing. Here we present spectroscopic observations of 14 PHAs, which we have used to derive their taxonomy, meteorite analogs, and mineralogy. Combining our results with the literature, we investigated how PHAs are distributed as a function of their dynamical and physical properties. In general, the “carbonaceous” PHAs seem to be particularly threatening, because of their high porosity (limiting the effectiveness of the main deflection techniques that could be used in space) and low inclination and minimum orbit intersection distance (MOID) with the Earth (favoring more frequent close approaches). V-type PHAs also present low MOID values, which can produce frequent close approaches (as confirmed by the recent discovery of a limited space weathering on their surfaces). We also identified those specific objects that deserve particular attention because of their extreme rotational properties, internal strength, or possible cometary nature. For PHAs and NEOs in general, we identified a possible anti-correlation between the elongation and the rotational period, in the range of P{sub rot} ≈ 5–80 hr. This would be compatible with the behavior of gravity-dominated aggregates in rotational equilibrium. For periods ≳80–90 hr, such a trend stops, possibly under the influence of the YORP effect and collisions. However, the statistics is very low, and further observational and theoretical work is required

  9. Toxicology of selenium in a freshwater reservoir: implications for environmental hazard evaluation and safety.

    PubMed

    Lemly, A D

    1985-12-01

    A study was conducted to document patterns of accumulation and toxicity of selenium to organisms in a power plant cooling reservoir in North Carolina. Selenium entered the reservoir by way of effluent from the coal ash disposal basin, which contained 100-200 micrograms Se/liter. Concentrations of selenium in the lake water averaged 10 micrograms/liter, but were accumulated from 519 times (periphyton) to 3975 times (visceral tissue, largemouth bass) in the biota. The pattern and degree of accumulation was essentially complete within 2 years after the initial operation of the power plant, and persisted throughout the remainder of the study: fishes greater than insects greater than annelids greater than molluscs greater than crustaceans greater than plankton greater than periphyton. The plantonic and detrital food pathways exposed fishes to potential dietary concentrations of selenium that were some 770 and 519-1395 times the waterborne exposure, respectively. Of the 20 species of fish originally present in the reservoir, 16 were entirely eliminated, 2 were rendered sterile but persisted as adults, 1 was eliminated but managed to recolonize from a relatively uncontaminated headwater area as sterile adults, and 1 was unaffected. Two nonnative fish species were accidentally introduced and established reproducing populations. Abundance and diversity of biota other than fishes was not affected. Relative to control habitats, the contaminated reservoir had concentrations of waterborne selenium that were 20-30 times background levels; the flora and fauna contained about 10-15 times background. The results show that selenium can accumulate and be biologically magnified to toxic levels in a reservoir even though waterborne concentrations are in the low microgram per liter range. This study also provides data which indicate that current toxicological information is neither accurate when used to predict the relative sensitivity of individual fish species to selenium, nor is it

  10. Potential hazards in smoke-flavored fish

    NASA Astrophysics Data System (ADS)

    Lin, Hong; Jiang, Jie; Li, Donghua

    2008-08-01

    Smoking is widely used in fish processing for the color and flavor. Smoke flavorings have evolved as a successful alternative to traditional smoking. The hazards of the fish products treated by liquid-smoking process are discussed in this review. The smoke flavoring is one important ingredient in the smoke-flavored fish. This paper gives the definition of smoke flavorings and the hazard of polycyclic aromatic hydrocarbons (PAHs) residue in the smoke flavorings on the market. It gives also an assessment of chemical hazards such as carcinogenic PAHs, especially Benzo-[ a]pyrene, as well as biological hazards such as Listeria monocytogenes, Clostridium botulinum, histamine and parasites in smoke-flavored fish. The limitations in regulations or standards are discussed. Smoke flavored fish have lower content of PAHs as compared with the traditional smoking techniques if the PAHs residue in smoke flavorings is controlled by regulations or standards.

  11. Waste explosives and other hazardous materials--hazard potential and remedial measures: an overview.

    PubMed

    Pandey, R K; Asthana, S N; Bhattacharya, B; Tiwari, Ila; Ghole, V S

    2007-07-01

    A large amount of energetic materials including propellants, high explosives, pyrotechnics are subjected to disposal either due to expiry of their useful life or rejection in the manufacturing process. The environmental regulations do not allow the hazardous materials for open burning / detonation in view of the health hazard involved in these operations. The present paper describes the hazard potential of energetic materials and associated hazardous chemicals. It also deals with global technological status for remedial measures of hazardous chemicals along with their merits and demerits.

  12. The potential of embryonic stem cells combined with -omics technologies as model systems for toxicology.

    PubMed

    Winkler, J; Sotiriadou, I; Chen, S; Hescheler, J; Sachinidis, A

    2009-01-01

    The derivation of pluripotent embryonic stem (ES) cell lines has opened up new areas of research in basic and applied science, most significantly in developmental biology and regenerative medicine. While application-oriented research has for the most part focussed on obtaining differentiated, organotypic cells from ES cells for future cell grafting therapies, ES cells have more immediate potential for use in toxicological in vitro assays used during drug development. ES cells are derived from blastocyst-stage embryos and offer an in vitro model for early development, thus enabling tests for teratogenicity testing in a human cell culture system and avoiding the pitfalls of inter-species differences. Differentiated, organotypic cells obtained from ES cells can potentially replace the primary cells and cell lines currently used for in vitro toxicology by offering a more consistent and potentially limitless source of differentiated cells. This can facilitate the establishment of comprehensive toxicogenomics and -proteomics databases and complement current databases that rely on data obtained from animal experiments. More recently, induced pluripotent stem (iPS) cells with ES cell-like properties have been obtained through reprogramming of somatic cells, thus enabling the generation of disease-specific cell lines. We review the potential of combining ES cells and ES cell-derived somatic cells with "omics" technologies for in vitro toxicology with a particular emphasis on the development of toxicogenomics and toxicoproteomics signatures. A separate section describes the potential of iPS cells for toxicology.

  13. Computational Toxicology as Implemented by the U.S. EPA: Providing High Throughput Decision Support Tools for Screening and Assessing Chemical Exposure, Hazard and Risk

    EPA Science Inventory

    Computational toxicology is the application of mathematical and computer models to help assess chemical hazards and risks to human health and the environment. Supported by advances in informatics, high-throughput screening (HTS) technologies, and systems biology, the U.S. Environ...

  14. Computational Toxicology as Implemented by the U.S. EPA: Providing High Throughput Decision Support Tools for Screening and Assessing Chemical Exposure, Hazard and Risk

    EPA Science Inventory

    Computational toxicology is the application of mathematical and computer models to help assess chemical hazards and risks to human health and the environment. Supported by advances in informatics, high-throughput screening (HTS) technologies, and systems biology, the U.S. Environ...

  15. Potentially Hazardous Objects (PHO) Mitigation Program

    NASA Astrophysics Data System (ADS)

    Huebner, Walter

    Southwest Research Institute (SwRI) and its partner, Los Alamos National Laboratory (LANL), are prepared to develop, implement, and expand procedures to avert collisions of potentially hazardous objects (PHOs) with Earth as recommended by NASA in its White Paper "Near- Earth Object Survey and Deflection Analysis of Alternatives" requested by the US Congress and submitted to it in March 2007. In addition to developing the general mitigation program as outlined in the NASA White Paper, the program will be expanded to include aggressive mitigation procedures for small (e.g., Tunguska-sized) PHOs and other short warning-time PHOs such as some long-period comet nuclei. As a first step the program will concentrate on the most likely and critical cases, namely small objects and long-period comet nuclei with short warning-times, but without losing sight of objects with longer warning-times. Objects smaller than a few hundred meters are of interest because they are about 1000 times more abundant than kilometer-sized objects and are fainter and more difficult to detect, which may lead to short warning times and hence short reaction times. Yet, even these small PHOs can have devastating effects as the 30 June 1908, Tungaska event has shown. In addition, long-period comets, although relatively rare but large (sometimes tens of kilometers in size), cannot be predicted because of their long orbital periods. Comet C/1983 H1 (IRAS-Araki-Alcock), for example, has an orbital period of 963.22 years, was discovered 27 April 1983, and passed Earth only two weeks later, on 11 May 1983, at a distance of 0.0312 AU. Aggressive methods and continuous alertness will be needed to defend against objects with such short warning times. While intact deflection of a PHO remains a key objective, destruction of a PHO and dispersion of the pieces must also be considered. The effectiveness of several alternative methods including nuclear demolition munitions, conventional explosives, and hyper

  16. Wildlife toxicology: biomarkers of genotoxic exposures at a hazardous waste site

    PubMed Central

    Matson, Cole W.; Gillespie, Annika M.; McCarthy, Chris; McDonald, Thomas J.; Bickham, John W.; Sullivan, Robert; Donnelly, K.C.

    2013-01-01

    A large number of hazardous waste sites in the United States have undergone the initial stages of remediation or containment. At many of the remaining sites, the potential for exposure to ecological receptors is a primary concern. This manuscript reports on studies to investigate the impact on ecological receptors exposed to complex mixtures at a former creosote facility. Currently there are isolated areas on-site that were not addressed in the initial removal action that appear to be releasing polycyclic aromatic hydrocarbons (PAHs) to the surrounding environment. The U.S. EPA collected environmental samples and performed ex situ sediment bioassays to measure chronic toxicity; whereas, this study describes an in situ study to measure biomarkers of effect in two ecological receptors. Mosquitofish (Gambusia affinis) and cricket frogs (Acris crepitans) were collected from a small intermittent creek adjacent to the site, and reference stations. A weight-of-evidence ecological risk assessment was completed for the amphibian and fish communities. The ecological risk assessment was developed using analysis of media chemistry, body burden of specific PAHs, bioassay results, community surveys, and cellular genome size variation as a biomarker of genotoxicity. Flow cytometric estimates of chromosomal damage were significantly elevated for both mosquitofish and cricket frogs inhabiting the contaminated site, relative to at least one reference site. Surface water screening values for fish and amphibians exceeded screening values for PAHs by more than one order of magnitude in the on-site creek, and sediment PAH concentrations were extremely high (up to 1,549 μg/dry g). Tissue concentrations of PAHs were below screening values. Media chemistry, bioassay and genotoxicity data all support the same conclusion that on-site PAHs continue to impact aquatic receptors. The genotoxicity findings are consistent with and contribute to results of the weight-of-evidence ecological risk

  17. POTENTIAL HAZARDS FROM NEUTRINO RADIATION AT MUON COLLIDERS.

    SciTech Connect

    KING,B.J.

    1999-03-29

    High energy muon colliders, such as the TeV-scale conceptual designs now being considered, are found to produce enough high energy neutrinos to constitute a potentially serious off-site radiation hazard in the neighborhood of the accelerator site. A general characterization of this radiation hazard is given, followed by an order-of-magnitude calculation for the off-site annual radiation dose and a discussion of accelerator design and site selection strategies to minimize the radiation hazard.

  18. Diagnostic yield of hair and urine toxicology testing in potential child abuse cases.

    PubMed

    Stauffer, Stephanie L; Wood, Stephanie M; Krasowski, Matthew D

    2015-07-01

    Detection of drugs in a child may be the first objective finding that can be reported in cases of suspected child abuse. Hair and urine toxicology testing, when performed as part of the initial clinical evaluation for suspected child abuse or maltreatment, may serve to facilitate the identification of at-risk children. Furthermore, significant environmental exposure to a drug (considered by law to constitute child abuse in some states) may be identified by toxicology testing of unwashed hair specimens. In order to determine the clinical utility of hair and urine toxicology testing in this population we performed a retrospective chart review on all children for whom hair toxicology testing was ordered at our academic medical center between January 2004 and April 2014. The medical records of 616 children aged 0-17.5 years were reviewed for injury history, previous medication and illicit drug use by caregiver(s), urine drug screen result (if performed), hair toxicology result, medication list, and outcome of any child abuse evaluation. Hair toxicology testing was positive for at least one compound in 106 cases (17.2%), with unexplained drugs in 82 cases (13.3%). Of these, there were 48 cases in which multiple compounds (including combination of parent drugs and/or metabolites within the same drug class) were identified in the sample of one patient. The compounds most frequently identified in the hair of our study population included cocaine, benzoylecgonine, native (unmetabolized) tetrahydrocannabinol, and methamphetamine. There were 68 instances in which a parent drug was identified in the hair without any of its potential metabolites, suggesting environmental exposure. Among the 82 cases in which hair toxicology testing was positive for unexplained drugs, a change in clinical outcome was noted in 71 cases (86.5%). Urine drug screens (UDS) were performed in 457 of the 616 reviewed cases. Of these, over 95% of positive UDS results could be explained by iatrogenic drug

  19. Asbestos substitutes: A closer look at potential health hazards

    SciTech Connect

    Myers, G.E.

    1987-01-01

    It appears that, with the possible exception of some relatively minor, specialized uses, the need for asbestos in industrial and consumer products has come to an end. Although there are apparent cost or performance penalties in some applications, adequate substitute materials have been found. It seems likely that these penalties will diminish with time. The existence of asbestos materials in older structures, however, will require continued vigilance. Although no material is completely safe under all conditions of exposure, the health hazards of many asbestos substitutes are relatively minor. Mica and perlite are low hazard materials, unless the perlite has >1% free silica. Vermiculite is presumed to be of low hazard potential, unless it is contaminated with asbestos fibers. Ordinary fibrous glass is one of the most common substitute materials, and it is of low inhalation hazard. Ultrafine glass fibers may be hazardous, but their use is thus far limited to special applications. Mineral wools are considered to be of low hazard by an acknowledged authority, ACGIH; however, some mineral wools have a high fraction of thin fibers, and these may be of higher hazard potential. Thin ceramic fiber material is presumed by many to be as hazardous as the asbestos it replaces, but a recently-completed animal study found no excess cancers. The uses of carbon fiber material are highly specialized, and there is little information on health effects as yet. Organic fibers appear to be of very low hazard potential. 8 refs.

  20. The potential hazards of xenotransplantation: an overview.

    PubMed

    Takeuchi, Y; Magre, S; Patience, C

    2005-04-01

    Xenotransplantation, in particular the transplantation of pig cells, tissues and organs into human recipients, may alleviate the current shortage of suitable allografts available for human transplantation. This overview addresses the physiological, immunological and microbial factors involved in xenotransplantation. The issues reviewed include the merits of using pigs as xenograft source species, the compatibility of pig and human organ physiology, and the rejection mechanism and attempts to overcome this immunological challenge. The authors discuss advances in the prevention of pig organ rejection through the creation of genetically modified pigs, more suited to the human micro-environment. Finally, in regard to microbial hazards, the authors review possible viral infections originating from pigs.

  1. The toxicology of bioregulators as potential agents of bioterrorism.

    PubMed

    Bokan, Slavko

    2005-06-01

    Bioregulators or modulators are biochemical compounds such as peptides, that occur naturally in organisms. Advances in biotechnology create the potential for the misuse of peptide bioregulators in offensive biological weapons programmes. Bioregulators are a new class of weapons that can damage the nervous system, alter mood, trigger psychological changes and kill. Over the last twenty years, neuroscience has produced an explosion of knowledge about receptor systems in the nerve cells that are of critical importance in receiving chemical transmitter substances released by other nerve cells. Bioregulators are closely related to substances normally found in the body that regulates normal biological processes. The potential military or terrorist use of bioregulators is similar to that of toxins. Together with increased research into toxins, the bioregulators have also been studied and synthesized. This paper presents a review of bioregulators that could be used in terrorist or other hostile activities.

  2. Potential health hazards of radiation. Fact Sheet

    SciTech Connect

    2009-05-19

    During World War II and the Cold War, the federal government developed and operated industrial facilities for the research, production, and testing of nuclear weapons, as well as other scientific and engineering research. These processes left a legacy of radioactive and chemical waste, environmental contamination, and hazardous facilities and materials at well over 100 sites. Some of these sites processed uranium and vanadium, and upon closure, left behind millions of cubic yards of mill tailings on the sites and throughout the nearby communities. The U.S. Department of Energy (DOE) administers the cleanup of these areas to minimize the risks to the public and environment from exposure to the tailings and the radon gas they produce.

  3. Toxicological benchmarks for screening contaminants of potential concern for effects on sediment-associated biota: 1996 revision

    SciTech Connect

    Jones, D.S.; Suter, G.W. II; Hull, R.N.

    1996-06-01

    A hazardous waste site may contain hundred of chemicals; therefore, it is important to screen contaminants of potential concern of the ecological risk assessment. Often this screening is done as part of a Screening Assessment, the purpose of which is to evaluate the available data, identify data gaps, and screen contaminants of potential concern. |Screening may be accomplished by using a set of toxicological benchmarks. These benchmarks are helpful in determining whether contaminants warrant further assessment or are at a level that requires no further attention. If a chemical concentration or the reported detection limit exceeds a proposed lower benchmark, more analysis is needed to determine the hazards posed by that chemical. If, however, the chemical concentration falls below the lower benchmark value, the chemical may be eliminated from further study. This report briefly describes three categories of approaches to the development of sediment quality benchmarks. These approaches are based on analytical chemistry, toxicity test results, and field survey data. A fourth integrative approach incorporates all three types of data.

  4. Toxicology of engineered nanomaterials - a review of carcinogenic potential.

    PubMed

    Tsuda, Hiroyuki; Xu, Jiegou; Sakai, Yuta; Futakuchi, Mitsuru; Fukamachi, Katsumi

    2009-01-01

    Nanotechnology has considerable socioeconomic potential. Benefits afforded by engineered nanoparticles (NP: defined as being less than 100 nm in diameter) are expected to be significant in fields such as plastics, energy, electronics, aerospace and medicine. However, NPs are being introduced into the market without adequate assessment of their potential toxicities. It is urgently important to conduct risk assessment of commercial NPs and establish a framework enabling risk management which is not subordinate to their commercial production. An overview of currently available carcinogenicity risk evaluation results of NP materials raises serious questions as to their safety. NP sized titanium dioxide (nTiO(2)) and carbon black (nCB) are carcinogenic to the lung of female rats, and the tumors preferentially include squamous cell morphology. Carbon nanotubes (CNT) induce mesotheliomas when applied intraperitoneally in rats and mice. Data for Fullerenes are insufficient to evaluate carcinogenic risk. Sub-chronic toxicity data indicate that, in general, NPs form aggregates and agglomerates and cause foreign body reactions at their applied sites with inflammatory cell, including macrophage, infiltration. These findings are similar to the biological effects of asbestos, a potent carcinogen, and indicate that careful assessment of NPs is indispensable.

  5. Space Toxicology: Environmental Health Considerations during Spaceflight Operations and Potential Paths for Research

    NASA Technical Reports Server (NTRS)

    Khan-Mayberry, Noreen N.; Sundaresan, Alemalu

    2009-01-01

    Space Toxicology is a specialized discipline for spaceflight, space habitation and occupation of celestial bodies including planets, moons and asteroids [1]. Astronaut explorers face unique challenges to their health while working and living with limited resources for rescue and medical care during space operation. At its core the practice of space toxicology to identify, assess and predict potential chemical contaminants and limit the astronaut s exposure to these environmental factors in order to protect crew health. Space toxicologists are also charged with setting safe exposure limits that will protect the astronaut against a multitude of chemical exposures, in a physiologically altered state. In order to maintain sustained occupation in space, toxicological risks are gauged and managed within the context of isolation, continual exposures, reuse of air and water, limited rescue options, and the necessary use of highly toxic compounds required for propulsion. As the space program move towards human presence and exploration other celestial bodies in situ toxicological risks, such as inhalation of unusual and/or reactive mineral dusts must also be analyzed and controlled. Placing humans for long-term presence in space creates several problems and challenges to the long-term health of the crew, such as bone-loss and immunological challenges and has spurred research into acute, chronic and episodic exposure of the pulmonary system to mineral dusts [2]. NASA has demonstrated that lunar soil contains several types of reactive dusts, including an extremely fine respirable component. In order to protect astronaut health, NASA is now investigating the toxicity of this unique class of dusts. Understanding how these reactive components behave "biochemically" in a moisture-rich pulmonary environment will aid in determining how toxic these particles are to humans. The data obtained from toxicological examination of lunar dusts will determine the human risk criteria for lunar

  6. Toxicological studies on potentiated ionophores in chickens. II. Compatibility study.

    PubMed

    Lehel, J; Laczay, P; Móra, Z; Semjén, G

    1995-01-01

    Two trials were carried out on a total of 2 x 360 Tetra-82 broiler chickens to study how the presence of the antioxidant duokvin as potentiating agent influenced the compatibility of reduced doses of monensin (12.5 mg/kg of feed) or maduramicin (3.0 mg/kg of feed) with other chemotherapeutic agents (tiamulin, erythromycin, sulfaquinoxaline, sulfachlorpyrazine, flumequine, tylosin, kitasamycin) widely used in broiler rearing. Compatibility was assessed on the basis of the appearance of clinical signs suggestive of toxic interaction, the mortality rate, body mass gain, feed consumption and drinking water intake, and changes in AST and LDH activities of the blood plasma. The monensin-duokvin combination (12.5 mg monensin/kg of feed + 120 mg duokvin/kg of feed) was found to be compatible with erythromycin, sulfaquinoxaline, sulfachlorpyrazine, flumequine, tylosin and kitasamycin. For tiamulin, a slight incompatibility was observed; however, this was much less severe than that found for monensin administered at a dose of 100 mg/kg of feed. The maduramicin-duokvin combination (3.0 mg maduramicin/kg of feed + 120 mg duokvin/kg of feed) was compatible with all the compounds tested; thus, it can be safely applied also in combination with tiamulin.

  7. Arachnid toxinology in Australia: from clinical toxicology to potential applications.

    PubMed

    Nicholson, Graham M; Graudins, Andis; Wilson, Harry I; Little, Michelle; Broady, Kevin W

    2006-12-01

    The unique geographic isolation of Australia has resulted in the evolution of a distinctive range of Australian arachnid fauna. Through the pioneering work of a number of Australian arachnologists, toxinologists, and clinicians, the taxonomy and distribution of new species, the effective clinical treatment of envenomation, and the isolation and characterisation of the many distinctive neurotoxins, has been achieved. In particular, work has focussed on several Australian arachnids, including red-back and funnel-web spiders, paralysis ticks, and buthid scorpions that contain neurotoxins capable of causing death or serious systemic envenomation. In the case of spiders, species-specific antivenoms have been developed to treat envenomed patients that show considerable cross-reactivity. Both in vitro and clinical case studies have shown they are particularly efficacious in the treatment of envenomation by spiders even from unrelated families. Despite their notorious reputation, the high selectivity and potency of a unique range of toxins from the venom of Australian arachnids will make them invaluable molecular tools for studies of neurotransmitter release and vesicle exocytosis as well as ion channel structure and function. The venoms of funnel-web spiders, and more recently Australian scorpions, have also provided a previously untapped rich source of insect-selective neurotoxins for the future development of biopesticides and the characterisation of previously unvalidated insecticide targets. This review provides a historical viewpoint of the work of many toxinologists to isolate and characterise just some of the toxins produced by such a unique group of arachnids and examines the potential applications of these novel peptides.

  8. Atmospheric hazards: Hail potential heating up

    NASA Astrophysics Data System (ADS)

    Allen, John T.

    2017-07-01

    There is widespread speculation as to whether hailstorms are getting more intense or frequent as the global climate warms. Now research suggests a potential increase in both the mean hail size and frequency of larger hail events over North America.

  9. Potential geologic hazards of Arctic gas hydrates

    SciTech Connect

    Collett, T.S. )

    1990-05-01

    Sediments of the Arctic region may contain enormous quantities of natural gas in the form of gas hydrates, which are crystalline substances composed of water and mostly methane gas. These ice-like substances are generally found in two distinct environments: (1) offshore in sediments of outer continental margins and (2) nearshore and onshore in areas associated with the occurrence of permafrost. Recently, US, Canadian, and Soviet researchers have described numerous drilling and production problems attributed to the presence of gas hydrates, including uncontrolled gas releases during drilling, collapsed casings, and gas leakage to the surface. When the drill bit penetrates a gas hydrate, the drilling mud, unless cooled significantly by the operator, will become highly gasified as the hydrate decomposes. The hydrate adjacent to the well bore will continue to decompose and gasify the drilling mud as long as drilling and/or production introduces heat into the hydrate-bearing interval. The production of hot fluids from depth through the permafrost and gas hydrate-bearing intervals adversely raises formation temperatures, thus decomposing the gas hydrates. If the disassociated, free gas is trapped behind the casing, reservoir pressures may substantially increase and cause the casing to collapse. In several wells in northern Alaska, the disassociated free gas has leaked to the surface outside the conductor casing. An additional drilling hazard associated with gas hydrates results from the sealing attributes of hydrates, which may trap large volumes of over pressured free gas at shallow depths. Even though documented problems attributed to the presence of gas hydrates have been relatively few, it is likely that as exploration and development activity moves farther offshore into deeper water (>300 m) and to higher latitudes in the Arctic, the frequency of gas hydrate-related problems will increase.

  10. An overview of the development, validation, and application of neurobehavioral and neuromolecular toxicity assessment batteries: potential applications to combustion toxicology.

    PubMed

    Rossi, J; Ritchie, G D; Macys, D A; Still, K R

    1996-12-31

    Currently, there are few alternatives to the use of animals in toxicology for human risk assessment. Neurobehavioral toxicology is an emerging area in which complex performance capacity is evaluated during or following toxicological exposure. While a number of single tests and a few more complex neurobehavioral batteries exist, no fully validated and comprehensive neurobehavioral toxicity assessment battery has yet been developed. The Neurobehavioral Toxicity Assessment Battery (NTAB) is a multi-test battery being developed by the Naval Medical Research Institute Detachment (Toxicology) (NMRI/TD) to categorize the potential neurobehavioral toxicity of compounds of Navy interest, especially those found in combustion atmospheres. The NTAB is intended to identify specific areas of deficit (e.g. motivational, sensory, motor, and cognitive) from complex changes in performance induced by toxic exposures, as well as to provide a mechanism to evaluate recovery of neurobehavioral integrity. Portions of the NTAB have been successfully used to assess the risk of brief exposure to low concentrations of combustion gases, including smoke from electrical aircraft fires, ozone-depleting substances and their replacements, and the novel neuroconvulsant trimethylolpropane phosphate. The goal of the NMRI/TD Neurobehavioral Toxicology Group and the Tri-Service Toxicology Consortium's neurobehavioral toxicology program is the incorporation of more molecular techniques involving neurophysiology, neuropharmacology, in vivo electrochemistry, and real-time microdialysis for correlative use with the neurobehavioral battery in human risk assessment. This overview discusses the application of neurobehavioral and neuromolecular endpoint test batteries to combustion toxicology.

  11. Computational toxicology as implemented by the U.S. EPA: providing high throughput decision support tools for screening and assessing chemical exposure, hazard and risk.

    PubMed

    Kavlock, Robert; Dix, David

    2010-02-01

    Computational toxicology is the application of mathematical and computer models to help assess chemical hazards and risks to human health and the environment. Supported by advances in informatics, high-throughput screening (HTS) technologies, and systems biology, the U.S. Environmental Protection Agency EPA is developing robust and flexible computational tools that can be applied to the thousands of chemicals in commerce, and contaminant mixtures found in air, water, and hazardous-waste sites. The Office of Research and Development (ORD) Computational Toxicology Research Program (CTRP) is composed of three main elements. The largest component is the National Center for Computational Toxicology (NCCT), which was established in 2005 to coordinate research on chemical screening and prioritization, informatics, and systems modeling. The second element consists of related activities in the National Health and Environmental Effects Research Laboratory (NHEERL) and the National Exposure Research Laboratory (NERL). The third and final component consists of academic centers working on various aspects of computational toxicology and funded by the U.S. EPA Science to Achieve Results (STAR) program. Together these elements form the key components in the implementation of both the initial strategy, A Framework for a Computational Toxicology Research Program (U.S. EPA, 2003), and the newly released The U.S. Environmental Protection Agency's Strategic Plan for Evaluating the Toxicity of Chemicals (U.S. EPA, 2009a). Key intramural projects of the CTRP include digitizing legacy toxicity testing information toxicity reference database (ToxRefDB), predicting toxicity (ToxCast) and exposure (ExpoCast), and creating virtual liver (v-Liver) and virtual embryo (v-Embryo) systems models. U.S. EPA-funded STAR centers are also providing bioinformatics, computational toxicology data and models, and developmental toxicity data and models. The models and underlying data are being made publicly

  12. Developmental Toxicology##

    EPA Science Inventory

    Developmental toxicology encompasses the study of developmental exposures, pharmacokinetics, mechanisms, pathogenesis, and outcomes potentially leading to adverse health effects. Manifestations of developmental toxicity include structural malformations, growth retardation, functi...

  13. Developmental Toxicology##

    EPA Science Inventory

    Developmental toxicology encompasses the study of developmental exposures, pharmacokinetics, mechanisms, pathogenesis, and outcomes potentially leading to adverse health effects. Manifestations of developmental toxicity include structural malformations, growth retardation, functi...

  14. Application of Bioassays in Toxicological Hazard, Risk and Impact Assessment of Dredged Sediments

    EPA Science Inventory

    Given the potential environmental consequences of dumped dredged harbour sediments it is vital to establish the potential risks from exposure before disposal at sea. Currently, European legislation for disposal of contaminated sediments at sea is based on chemical analysis of a l...

  15. Application of Bioassays in Toxicological Hazard, Risk and Impact Assessment of Dredged Sediments

    EPA Science Inventory

    Given the potential environmental consequences of dumped dredged harbour sediments it is vital to establish the potential risks from exposure before disposal at sea. Currently, European legislation for disposal of contaminated sediments at sea is based on chemical analysis of a l...

  16. Potential health hazards of eating red meat.

    PubMed

    Wolk, A

    2017-02-01

    Red meat (beef, veal, pork, lamb and mutton) consumption contributes several important nutrients to the diet, for example essential amino acids, vitamins (including B12) and minerals (including iron and zinc). Processed red meat (ham, sausages, bacon, frankfurters, salami, etc.) undergoes treatment (curing, smoking, salting or the use of chemical preservatives and additives) to improve its shelf life and/or taste. During recent decades, consumption of red meat has been increasing globally, especially in developing countries. At the same time, there has been growing evidence that high consumption of red meat, especially of processed meat, may be associated with an increased risk of several major chronic diseases. Here, a comprehensive summary is provided of the accumulated evidence based on prospective cohort studies regarding the potential adverse health effects of red meat consumption on major chronic diseases, such as diabetes, coronary heart disease, heart failure, stroke and cancer at several sites, and mortality. Risk estimates from pooled analyses and meta-analyses are presented together with recently published findings. Based on at least six cohorts, summary results for the consumption of unprocessed red meat of 100 g day(-1) varied from nonsignificant to statistically significantly increased risk (11% for stroke and for breast cancer, 15% for cardiovascular mortality, 17% for colorectal and 19% for advanced prostate cancer); for the consumption of 50 g day(-1) processed meat, the risks were statistically significantly increased for most of the studied diseases (4% for total prostate cancer, 8% for cancer mortality, 9% for breast, 18% for colorectal and 19% for pancreatic cancer, 13% for stroke, 22% for total and 24% for cardiovascular mortality and 32% for diabetes). Potential biological mechanisms underlying the observed risks and the environmental impact of red meat production are also discussed. The evidence-based integrated message is that it is

  17. Green toxicology.

    PubMed

    Maertens, Alexandra; Anastas, Nicholas; Spencer, Pamela J; Stephens, Martin; Goldberg, Alan; Hartung, Thomas

    2014-01-01

    Historically, early identification and characterization of adverse effects of industrial chemicals was difficult because conventional toxicological test methods did not meet R&D needs for rapid, relatively inexpensive methods amenable to small amounts of test material. The pharmaceutical industry now front-loads toxicity testing, using in silico, in vitro, and less demanding animal tests at earlier stages of product development to identify and anticipate undesirable toxicological effects and optimize product development. The Green Chemistry movement embraces similar ideas for development of less toxic products, safer processes, and less waste and exposure. Further, the concept of benign design suggests ways to consider possible toxicities before the actual synthesis and to apply some structure/activity rules (SAR) and in silico methods. This requires not only scientific development but also a change in corporate culture in which synthetic chemists work with toxicologists. An emerging discipline called Green Toxicology (Anastas, 2012) provides a framework for integrating the principles of toxicology into the enterprise of designing safer chemicals, thereby minimizing potential toxicity as early in production as possible. Green Toxicology`s novel utility lies in driving innovation by moving safety considerations to the earliest stage in a chemical`s lifecycle, i.e., to molecular design. In principle, this field is no different than other subdisciplines of toxicology that endeavor to focus on a specific area - for example, clinical, environmental or forensic toxicology. We use the same principles and tools to evaluate an existing substance or to design a new one. The unique emphasis is in using 21st century toxicology tools as a preventative strategy to "design out" undesired human health and environmental effects, thereby increasing the likelihood of launching a successful, sustainable product. Starting with the formation of a steering group and a series of workshops

  18. Radium dial watches, a potentially hazardous legacy?

    PubMed

    Gillmore, Gavin K; Crockett, Robin; Denman, Tony; Flowers, Alan; Harris, Richard

    2012-09-15

    from 0.013 to 0.875 μCi (0.46 to 32.38 kBq) for wrist watches. The risk from old watches containing radium appears to have been largely forgotten today. This paper indicates a health risk, particular to collectors, but with knowledge and appropriate precautions the potential risks can be reduced.

  19. Nanominerals, fullerene aggregates, and hazardous elements in coal and coal combustion-generated aerosols: An environmental and toxicological assessment.

    PubMed

    Saikia, Jyotilima; Narzary, Bardwi; Roy, Sonali; Bordoloi, Manobjyoti; Saikia, Prasenjit; Saikia, Binoy K

    2016-12-01

    Studies on coal-derived nanoparticles as well as nano-minerals are important in the context of the human health and the environment. The coal combustion-generated aerosols also affect human health and environmental quality aspects in any coal-fired station. In this study, the feed coals and their combustion-generated aerosols from coal-fired boilers of two tea industry facilities were investigated for the presence of nanoparticles/nano minerals, fullerene aggregates, and potentially hazardous elements (PHEs). The samples were characterized by using X-ray diffraction (XRD), Time-of-flight secondary ion mass spectroscopy (TOF-SIMS), High resolution-transmission electron microscopy/energy dispersive spectroscopy (HR-TEM/EDS) and Ultra Violet-visible spectroscopy (UV-Vis) to know their extent of environmental risks to the human health when present in coals and aerosols. The feed coals contain mainly clay minerals, whilst glass fragments, spinel, quartz, and other minerals occur in lesser quantities. The PM samples contain potentially hazardous elements (PHEs) like As, Pb, Cd and Hg. Enrichment factor of the trace elements in particulate matters (PMs) was calculated to determine their sources. The aerosol samples were also found to contain nanomaterials and ultrafine particles. The fullerene aggregates along with potentially hazardous elements were also detected in the aerosol samples. The cytotoxicity studies on the coal combustion-generated PM samples show their potential risk to the human health. This detailed investigation on the inter-relationship between the feed coals and their aerosol chemistry will be useful for understanding the extent of environmental hazards and related human health risk.

  20. Toxicological benchmarks for screening contaminants of potential concern for effects on sediment-associated biota: 1994 Revision. Environmental Restoration Program

    SciTech Connect

    Hull, R.N. |; Suter, G.W. II

    1994-06-01

    Because a hazardous waste site may contain hundreds of chemicals, it is important to screen contaminants of potential concern for the ecological risk assessment. Often this screening is done as part of a Screening Assessment, the purpose of which is to evaluate the available data, identify data gaps, and screen contaminants of potential concern. Screening may be accomplished by using a set of toxicological benchmarks. These benchmarks are helpful in determining whether contaminants warrant further assessment or are at a level that requires no further attention. If a chemical concentration or the reported detection limit exceeds a proposed lower benchmark, more analysis is needed to determine the hazards posed by that chemical. If, however, the chemical concentration falls below the lower benchmark value, the chemical may be eliminated from further study. This report briefly describes three categories of approaches to the development of sediment quality benchmarks. These approaches are based on analytical chemistry, toxicity test and field survey data. A fourth integrative approach incorporates all three types of data. The equilibrium partitioning approach is recommended for screening nonpolar organic contaminants of concern in sediments. For inorganics, the National Oceanic and Atmospheric Administration has developed benchmarks that may be used for screening. There are supplemental benchmarks from the province of Ontario, the state of Wisconsin, and US Environmental Protection Agency Region V. Pore water analysis is recommended for polar organic compounds; comparisons are then made against water quality benchmarks. This report is an update of a prior report. It contains revised ER-L and ER-M values, the five EPA proposed sediment quality criteria, and benchmarks calculated for several nonionic organic chemicals using equilibrium partitioning.

  1. Database for potential hazards from future volcanic eruptions in California

    USGS Publications Warehouse

    White, Melissa N.; Ramsey, David W.; Miller, C. Dan

    2011-01-01

    More than 500 volcanic vents have been identified in the State of California. At least 76 of these vents have erupted, some repeatedly, during the past 10,000 yr. Past volcanic activity has ranged in scale and type from small rhyolitic and basaltic eruptions through large catastrophic rhyolitic eruptions. Sooner or later, volcanoes in California will erupt again, and they could have serious impacts on the health and safety of the State's citizens as well as on its economy. This report describes the nature and probable distribution of potentially hazardous volcanic phenomena and their threat to people and property. It includes hazard-zonation maps that show areas relatively likely to be affected by future eruptions in California. This digital release contains information from maps of potential hazards from future volcanic eruptions in the state of California, published as Plate 1 in U.S. Geological Survey Bulletin 1847. The main component of this digital release is a spatial database prepared using geographic information systems (GIS) applications. This release also contains links to files to view or print the map plate, main report text, and accompanying hazard tables from Bulletin 1847. It should be noted that much has been learned about the ages of eruptive events in the State of California since the publication of Bulletin 1847 in 1989. For the most up to date information on the status of California volcanoes, please refer to the U.S. Geological Survey Volcano Hazards Program website.

  2. National toxicology program chemical nomination and selection process

    SciTech Connect

    Selkirk, J.K.

    1990-12-31

    The National Toxicology Program (NTP) was organized to support national public health programs by initiating research designed to understand the physiological, metabolic, and genetic basis for chemical toxicity. The primary mandated responsibilities of NTP were in vivo and vitro toxicity testing of potentially hazardous chemicals; broadening the spectrum of toxicological information on known hazardous chemicals; validating current toxicological assay systems as well as developing new and innovative toxicity testing technology; and rapidly communicating test results to government agencies with regulatory responsibilities and to the medical and scientific communities. 2 figs.

  3. Testing of toxicology and emissions-sampling methodology for ocean incineration of hazardous wastes. Final report, January 1985-January 1986

    SciTech Connect

    Boehm, P.; Cooke, M.; Carr, S.; Piispanen, W.; Werme, C.

    1988-05-01

    This report addresses the development and testing of a system to expose marine organisms to hazardous-waste emissions in order to assess the potential toxicity of incinerator plumes at sea as they contact the marine environment through air-sea exchange and initial mixing. A sampling train was designed and tested at EPA's land-based hazardous-waste incinerator, using transformer oil as a waste feed. The incinerator was operated under conditions which would be appropriate for at-sea incinerators. The sampling train (Marine Incineration Biological Assessment Sampler--MIBAS) provides a sea-water sample containing a plume emission for the marine organisms testing. Five toxicity-test protocols were refined and/or developed for use in the program: (1) a sea-urchin fertilization test; (2) a chronic test using macroalgae Champia parvula; (3) a 7-day chronic test using growth and reproduction of the crustacean Mysidopsis bahia; (4) a 7-day growth and survival test with the fish Menidia beryllina; and (5) a 7-day life-cycle test using the archiannelid worm Dinophilus gyrocilatus. The results of applying these tests during a hazardous-waste burn are given.

  4. Formaldehyde: toxicology and hazards

    SciTech Connect

    Casteel, S.W.; Vernon, R.J.; Bailey, E.M. Jr.

    1987-02-01

    The widespread use of formaldehyde-based resins had led to the observation of consumer annoyance and health problems associated with its release. Formaldehyde vapor now is known to off-gas from many of these products. Vapor exposure of humans results in symptoms of eye and upper respiratory tract irritation. Inhaled formaldehyde also produces nasal carcinomas in rats and mice (following exposure to 14.1 ppm in mice and 5.6 ppm in rats for 6 hr/day, 5 days/week for 24 mo). These findings resulted in intensified concern over the amount of formaldehyde released into the indoor environment from various laboratory and consumer products.

  5. Implications of the Differential Toxicological Effects of III-V Ionic and Particulate Materials for Hazard Assessment of Semiconductor Slurries.

    PubMed

    Jiang, Wen; Lin, Sijie; Chang, Chong Hyun; Ji, Zhaoxia; Sun, Bingbing; Wang, Xiang; Li, Ruibin; Pon, Nanetta; Xia, Tian; Nel, André E

    2015-12-22

    Because of tunable band gaps, high carrier mobility, and low-energy consumption rates, III-V materials are attractive for use in semiconductor wafers. However, these wafers require chemical mechanical planarization (CMP) for polishing, which leads to the generation of large quantities of hazardous waste including particulate and ionic III-V debris. Although the toxic effects of micron-sized III-V materials have been studied in vivo, no comprehensive assessment has been undertaken to elucidate the hazardous effects of submicron particulates and released III-V ionic components. Since III-V materials may contribute disproportionately to the hazard of CMP slurries, we obtained GaP, InP, GaAs, and InAs as micron- (0.2-3 μm) and nanoscale (<100 nm) particles for comparative studies of their cytotoxic potential in macrophage (THP-1) and lung epithelial (BEAS-2B) cell lines. We found that nanosized III-V arsenides, including GaAs and InAs, could induce significantly more cytotoxicity over a 24-72 h observation period. In contrast, GaP and InP particulates of all sizes as well as ionic GaCl3 and InCl3 were substantially less hazardous. The principal mechanism of III-V arsenide nanoparticle toxicity is dissolution and shedding of toxic As(III) and, to a lesser extent, As(V) ions. GaAs dissolves in the cell culture medium as well as in acidifying intracellular compartments, while InAs dissolves (more slowly) inside cells. Chelation of released As by 2,3-dimercapto-1-propanesulfonic acid interfered in GaAs toxicity. Collectively, these results demonstrate that III-V arsenides, GaAs and InAs nanoparticles, contribute in a major way to the toxicity of III-V materials that could appear in slurries. This finding is of importance for considering how to deal with the hazard potential of CMP slurries.

  6. Engineered Nanomaterials, Sexy New Technology and Potential Hazards

    SciTech Connect

    Beaulieu, R A

    2009-05-04

    Engineered nanomaterials enhance exciting new applications that can greatly benefit society in areas of cancer treatments, solar energy, energy storage, and water purification. While nanotechnology shows incredible promise in these and other areas by exploiting nanomaterials unique properties, these same properties can potentially cause adverse health effects to workers who may be exposed during work. Dispersed nanoparticles in air can cause adverse health effects to animals not merely due to their chemical properties but due to their size, structure, shape, surface chemistry, solubility, carcinogenicity, reproductive toxicity, mutagenicity, dermal toxicity, and parent material toxicity. Nanoparticles have a greater likelihood of lung deposition and blood absorption than larger particles due to their size. Nanomaterials can also pose physical hazards due to their unusually high reactivity, which makes them useful as catalysts, but has the potential to cause fires and explosions. Characterization of the hazards (and potential for exposures) associated with nanomaterial development and incorporation in other products is an essential step in the development of nanotechnologies. Developing controls for these hazards are equally important. Engineered controls should be integrated into nanomaterial manufacturing process design according to 10CFR851, DOE Policy 456.1, and DOE Notice 456.1 as safety-related hardware or administrative controls for worker safety. Nanomaterial hazards in a nuclear facility must also meet control requirements per DOE standards 3009, 1189, and 1186. Integration of safe designs into manufacturing processes for new applications concurrent with the developing technology is essential for worker safety. This paper presents a discussion of nanotechnology, nanomaterial properties/hazards and controls.

  7. Understanding the toxicological potential of aerosol organic compounds using informatics based screening

    NASA Astrophysics Data System (ADS)

    Topping, David; Decesari, Stefano; Bassan, Arianna; Pavan, Manuela; Ciacci, Andrea

    2016-04-01

    Exposure to atmospheric particulate matter is responsible for both short-term and long-term adverse health effects. So far, all efforts spent in achieving a systematic epidemiological evidence of specific aerosol compounds determining the overall aerosol toxicity were unsuccessful. The results of the epidemiological studies apparently conflict with the laboratory toxicological analyses which have highlighted very different chemical and toxicological potentials for speciated aerosol compounds. Speciation remains a problem, especially for organic compounds: it is impossible to conduct screening on all possible molecular species. At the same time, research on toxic compounds risks to be biased towards the already known compounds, such as PAHs and dioxins. In this study we present results from an initial assessment of the use of in silico methods (i.e. (Q)SAR, read-across) to predict toxicity of atmospheric organic compounds including evaluation of applicability of a variety of popular tools (e.g. OECD QSAR Toolbox) for selected endpoints (e.g. genotoxicity). Compounds are categorised based on the need of new experimental data for the development of in silico approaches for toxicity prediction covering this specific chemical space, namely the atmospheric aerosols. Whilst only an initial investigation, we present recommendations for continuation of this work.

  8. SMOG-CHAMBER TOXICOLOGY BETTER ESTIMATES THE TRUE TOXIC POTENTIAL OF ATMOSPHERIC MIXTURES

    EPA Science Inventory

    The chemistry of hazardous air pollutants (HAPs) have been studied for many years, yet little is known about how these chemicals, once interacted with urban atmospheres, affect healthy and susceptible individuals. The toxic potential of these very reactive compounds once they int...

  9. SMOG-CHAMBER TOXICOLOGY BETTER ESTIMATES THE TRUE TOXIC POTENTIAL OF ATMOSPHERIC MIXTURES

    EPA Science Inventory

    The chemistry of hazardous air pollutants (HAPs) have been studied for many years, yet little is known about how these chemicals, once interacted with urban atmospheres, affect healthy and susceptible individuals. The toxic potential of these very reactive compounds once they int...

  10. The potential carcinogenic hazards of electromagnetic radiation: a review.

    PubMed

    Horn, Y

    1995-01-01

    The purpose of this review is to summarize the experience gained thus far on the potential health hazards of electromagnetic radiation. Far less information is available in the medical literature on this kind of radiation than on ionizing radiation, which has been recognized as a health hazard long ago. Increased rates of cancer morbidity and mortality have been noted in populations exposed to ionizing radiation, and international quantitative safety criteria have been established. Electromagnetic radiation (radiofrequency levels between several hundred kilohertz and 300 GHz) is not an infrequent phenomenon. The literature consists mainly of epidemiological studies out of which grew the assumption that this kind of radiation may be carcinogenic. However, only limited data are available on electromagnetic radiation as a potential cancer inducer. A review of the literature does not demonstrate a direct and clear linkage between electromagnetic radiation and the occurrence of malignant tumors, but much more research and clarification are necessary before reaching any conclusions.

  11. Hazardous substance releases at the community level: a practical approach to analyzing potential health threats.

    PubMed

    Neufer, L; Narkunas, D

    1994-07-01

    1. When a hazardous substance release occurs in a community, public health nurses must consider whether community members have been exposed, and whether that exposure is sufficient to impact public health. 2. An exposure pathway is the process by which an individual is exposed to contaminants that originate from some source of contamination. The exposure pathway method is effective in determining whether community members are exposed to hazardous substances in their community. 3. After determining a completed exposure pathway, a toxicological analysis estimates the dose of hazardous substances community members may have received and whether that dose may increase risks for an adverse health effect. 4. The Agency for Toxic Substances and Disease Registry (ATSDR) provides information to health care professionals that can assist them in conducting exposure and toxicological analyses.

  12. Hazard Mitigation Potential of Earth-Sheltered Residences

    DTIC Science & Technology

    1983-11-01

    433-451 (1974). z ai’man, G ., R. Duncan, and J. Holbeck, Innovations and Organizations, New York: ~ John Wiley, 1973. Ziebarth, Allan M., Personal...Press Zaltman, G ., Duncan,E. Holbeck,J., Innovations and Organizationa [ 1973.] New York: John Wiley 3. Policy Isplementation PardachE., Ine...AA/3• 3C7 Hazard Mitigation Potential of UIYIONEarth-Sheltered Residecriot CARBIDE C. V. Chester H. B. Shapira G . A. Gristy M. Schw~eitzer S. A

  13. Liquefaction hazard potential in north eastern united arab emirates

    NASA Astrophysics Data System (ADS)

    Al-Homoud, A.

    2003-04-01

    The United Arab Emirates is adjacent to the Iranian plateau characterized by very high density of active and recent faults. The Iranian plateau is one of the seismically active areas of the world and frequently suffers destructive and catastrophic earthquakes that cause heavy loss of human life and widespread damage. Therefore seismic risk in the North Eastern UAE (Sharjah and Dubai) is due to the neighboring very active Iranian seismotectonic province. As almost all foundation soils in the UAE are cohesionless material, which is clearly identified as recent fill deposits in major industrial and residential areas, and given the rapid on-shore infrastructure developments in the North Eastern UAE, and due to the lack of geo-hazards maps, it is considered vital to develop liquefaction hazard maps for these areas. The earthquake risk was brought to the attention of the public and the government upon the recent March 11, 2002 earthquake of magnitude 5.1 on Richter Scale that struck the northern emirates and caused slight damages. Initial seismic hazard assessment studies showed that Design Horizontal Peak Ground Accelerations (PGA) in Sharjah and Dubai with 90% probabilities of non-exceedence in 50 years is around 200 cm/sec^2. This study is concerned with the development of liquefaction hazard maps in North Eastern Emirates UAE Cities of Sharjah and Dubai. Liquefaction hazard potential for various soil deposits in these cities is evaluated for different Peak Ground Acceleation Values. Data from thorough geotechnical studies were evaluated. This include boreholes drilling (with SPT tests) and shear strength for representative sand samples taken from several boreholes and at different depths. Liquefaction hazard potential is evaluated at representative sites in the city of Dubai and Sharjah using the state of the art liquefaction potential evaluation methods (e.g. Seed's cyclic stress ratio approach). Results indicate clearly that the coastal areas have a high potential

  14. Potential Operating Room Fire Hazard of Bone Cement.

    PubMed

    Sibia, Udai S; Connors, Kevin; Dyckman, Sarah; Zahiri, Hamid R; George, Ivan; Park, Adrian E; MacDonald, James H

    Approximately 600 cases of operating room (OR) fires are reported annually. Despite extensive fire safety education and training, complete elimination of OR fires still has not been achieved. Each fire requires an ignition source, a fuel source, and an oxidizer. In this case report, we describe the potential fire hazard of bone cement in the OR. A total knee arthroplasty was performed with a standard medial parapatellar arthrotomy. Tourniquet control was used. After bone cement was applied to the prepared tibial surface, the surgeon used an electrocautery device to resect residual lateral meniscus tissue-and started a fire in the operative field. The surgeon suffocated the fire with a dry towel and prevented injury to the patient. We performed a PubMed search with a cross-reference search for relevant papers and found no case reports outlining bone cement as a potential fire hazard in the OR. To our knowledge, this is the first case report identifying bone cement as a fire hazard. OR fires related to bone cement can be eliminated by correctly assessing the setting time of the cement and avoiding application sites during electrocautery.

  15. Regional Landslide Hazard Assessment Considering Potential Climate Change

    NASA Astrophysics Data System (ADS)

    Almeida, S.; Holcombe, E.; Pianosi, F.; Wagener, T.

    2016-12-01

    Landslides have many negative economic and societal impacts, including the potential for significant loss of life and damage to infrastructure. These risks are likely to be exacerbated in the future by a combination of climatic and socio-economic factors. Climate change, for example, is expected to increase the occurrence of rainfall-triggered landslides, because a warmer atmosphere tends to produce more high intensity rainfall events. Prediction of future changes in rainfall, however, is subject to high levels of uncertainty, making it challenging for decision-makers to identify the areas and populations that are most vulnerable to landslide hazards. In this study, we demonstrate how a physically-based model - the Combined Hydrology and Stability Model (CHASM) - can be used together with Global Sensitivity Analysis (GSA) to explore the underlying factors controlling the spatial distribution of landslide risks across a regional landscape, while also accounting for deep uncertainty around potential future rainfall triggers. We demonstrate how GSA can be used to analyse CHASM which in turn represents the spatial variability of hillslope characteristics in the study region, while accounting for other uncertainties. Results are presented in the form of landslide hazard maps, utilising high-resolution digital elevation datasets for a case study in St Lucia in the Caribbean. Our findings about spatial landslide hazard drivers have important implications for data collection approaches and for long-term decision-making about land management practices.

  16. Toxicological approaches to complex mixtures.

    PubMed Central

    Mauderly, J L

    1993-01-01

    This paper reviews the role of toxicological studies in understanding the health effects of environmental exposures to mixtures. The approach taken is to review mixtures that have received the greatest emphasis from toxicology; major mixtures research programs; the toxicologist's view of mixtures and approaches to their study; and the complementary roles of toxicological, clinical, and epidemiological studies. Studies of tobacco smoke, engine exhaust, combustion products, and air pollutants comprise most of the past research on mixtures. Because of their great experimental control over subjects, exposures, and endpoints, toxicologists tend to consider a wider range of toxic interactions among mixture components and sequential exposures than is practical for human studies. The three fundamental experimental approaches used by toxicologists are integrative (studying the mixture as a whole), dissective (dissecting a mixture to determine causative constituents), and synthetic (studying interactions between agents in simple combinations). Toxicology provides information on potential hazards, mechanisms by which mixture constituents interact to cause effects, and exposure dose-effect relationships; but extrapolation from laboratory data to quantitative human health risks is problematic. Toxicological, clinical, and epidemiological approaches are complementary but are seldom coordinated. Fostering synergistic interactions among the disciplines in studying the risks from mixtures could be advantageous. PMID:7515806

  17. Prioritization of pharmaceuticals for potential environmental hazard through leveraging a large-scale mammalian pharmacological dataset.

    PubMed

    Berninger, Jason P; LaLone, Carlie A; Villeneuve, Daniel L; Ankley, Gerald T

    2016-04-01

    The potential for pharmaceuticals in the environment to cause adverse ecological effects is of increasing concern. Given the thousands of active pharmaceutical ingredients (APIs) that can enter the aquatic environment through human and/or animal (e.g., livestock) waste, a current challenge in aquatic toxicology is identifying those that pose the greatest risk. Because empirical toxicity information for aquatic species is generally lacking for pharmaceuticals, an important data source for prioritization is that generated during the mammalian drug development process. Applying concepts of species read-across, mammalian pharmacokinetic data were used to systematically prioritize APIs by estimating their potential to cause adverse biological consequences to aquatic organisms, using fish as an example. Mammalian absorption, distribution, metabolism, and excretion (ADME) data (e.g., peak plasma concentration, apparent volume of distribution, clearance rate, and half-life) were collected and curated, creating the Mammalian Pharmacokinetic Prioritization For Aquatic Species Targeting (MaPPFAST) database representing 1070 APIs. From these data, a probabilistic model and scoring system were developed and evaluated. Individual APIs and therapeutic classes were ranked based on clearly defined read-across assumptions for translating mammalian-derived ADME parameters to estimate potential hazard in fish (i.e., greatest predicted hazard associated with lowest mammalian peak plasma concentrations, total clearance and highest volume of distribution, half-life). It is anticipated that the MaPPFAST database and the associated API prioritization approach will help guide research and/or inform ecological risk assessment. Published 2015 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America.

  18. Broadband Photometry of the Potentially Hazardous Asteroid 251346 (2007 SJ)

    NASA Astrophysics Data System (ADS)

    Hicks, M.; Ebelhar, S.

    2014-01-01

    The Near-Earth Asteroid (NEA) 251346 (2007 SJ) was discovered by the LINEAR Sky Survey on September 17, 2007 (MPEC 2007-S17). With a Minimum Orbit Intersection Distance (MOID) of 0.045 AU and an expected diameter between 1.3~2.8 km, this object has been designated as a Potentially Hazardous Asteroid (PHA) by the Minor Planet Center. We obtained two partial nights of broadband Bessel BVRI photometry (October 10 and December 11, 2013) and one night (December 13, 2013) at the JPL Table Mountain 0.6-m telescope (TMO), as summarized in Table 1.

  19. Potential hazards from future volcanic eruptions in California

    SciTech Connect

    Miller, C.D.

    1989-01-01

    More than 500 volcanic vents have been identified in the State of California. At least 76 of these vents have erupted, some repeatedly, during the last 10,000 yr. Past volcanic activity has ranged in scale and type from small rhyolitic and basaltic eruptions through large catastrophic rhyolitic eruptions. Volcanoes in California will erupt again, and they could have serious impacts on the health, safety, and economy of the State's citizens as well as that of neighboring states. The nature and probable distribution of potentially hazardous volcanic phenomena and their threat to people and property is described in this bulletin.

  20. The environmental and medical geochemistry of potentially hazardous materials produced by disasters

    USGS Publications Warehouse

    Plumlee, Geoffrey S.; Morman, Suzette A.; Meeker, G.P.; Hoefen, Todd M.; Hageman, Philip L.; Wolf, Ruth E.

    2014-01-01

    Many natural or human-caused disasters release potentially hazardous materials (HM) that may pose threats to the environment and health of exposed humans, wildlife, and livestock. This chapter summarizes the environmentally and toxicologically significant physical, mineralogical, and geochemical characteristics of materials produced by a wide variety of recent disasters, such as volcanic eruptions, hurricanes and extreme storms, spills of mining/mineral-processing wastes or coal extraction by-products, and the 2001 attacks on and collapse of the World Trade Center towers. In describing these characteristics, this chapter also illustrates the important roles that geochemists and other earth scientists can play in environmental disaster response and preparedness. In addition to characterizing in detail the physical, chemical, and microbial makeup of HM generated by the disasters, these roles also include (1) identifying and discriminating potential multiple sources of the materials; (2) monitoring, mapping, and modeling dispersal and evolution of the materials in the environment; (3) understanding how the materials are modified by environmental processes; (4) identifying key characteristics and processes that influence the materials' toxicity to exposed humans and ecosystems; (5) estimating shifts away from predisaster environmental baseline conditions; and (6) using geochemical insights learned from past disasters to help estimate, prepare for, and increase societal resilience to the environmental and related health impacts of future disasters.

  1. Identification of potential hazards associated with new residential construction.

    PubMed

    Methner, M M

    2000-02-01

    There were several advantages and limitations of this observational study. The most important advantage of this study was the opportunity to observe residential construction workers performing their jobs. By observing work practices, valuable information was gathered about specific trades and their potential exposure to various chemical and physical agents. This information will be useful in guiding subsequent exposure assessments. Probably the greatest limitation of this study was the lack of participation by homebuilders. Ideally, observations of construction processes would have been more objective if the study included the participation of more than one homebuilder. Aside from one worker who was observed to wear safety glasses, leather gloves, and a dust mask, virtually no personal protective equipment (PPE) was observed onsite. Often small contractors do not have the financial resources necessary to procure the appropriate PPE and issue these items to the workers. Based on hazard prevalence, professional judgement, and the degree of hazardous product use, potential exposures that warrant quantitative sampling efforts during Phase 2 of this study are: bulldozer/backhoe operators--noise, vibration, diesel exhaust; concrete workers--naphtha, mineral spirits, Portland cement; asphalt workers--petroleum hydrocarbons, asphalt, mineral spirits; plumbers--methylethyl ketone, acetone, tetrahydrofuran, cyclohexanone; drywall finishers--total and respirable dust, hexane, acetone; painters--ethylene glycol, VOCs; masons--dust (during the preparation of mortar); floor preparation technicians--total and respirable dust; and ceramic tile installers--toluene, naphtha, silica (from grout powder).

  2. Hazard identification of the potential for dieldrin carcinogenicity to humans.

    PubMed

    Stern, Alan H

    2014-05-01

    Although dieldrin׳s use in the U.S. was partially banned in the 1970s and its use was completely eliminated in 1987, dieldrin continues to be a common contaminant at hazardous waste sites. The USEPA׳s current cancer potency estimate for dieldrin was derived in 1987 and is based on the production of mouse liver tumors. Because of its environmental persistence and its relatively high USEPA cancer potency estimate, dieldrin functions as a cleanup "driver" in many hazardous site remediations. Since 1987, new risk assessment perspectives and new data on dieldrin׳s carcinogenic potential have arisen. This review presents a reassessment of dielrin׳s human cancer potential in light of these new data and new perspectives. Based on this reassessment, dieldrin may be carcinogenic through multiple modes of action. These modes of action may operate within the same tissue, or may be specific to individual tissues. Of the several possible carcinogenic modes of action for dieldrin, one or more may be more relevant to human cancer risk than others, but the relative importance of each is unknown. In addition, neither the details of the possible modes of action, nor the shape of the tumor dose-response curves associated with each are sufficiently well known to permit quantitative cancer dose-response modeling. Thus, the mouse liver tumor data used by the USEPA in its 1987 assessment remain the only quantitative data available for cancer dose-response modeling. Copyright © 2014 Elsevier Inc. All rights reserved.

  3. Information profiles on potential occupational hazards: sulfur tetrafluoride. Second draft

    SciTech Connect

    Not Available

    1981-04-01

    Information on the potential occupational hazards from sulfur tetrafluoride was reviewed. Topics discussed included chemical and physical properties, production, use, manufacturers and distributors, manufacturing processes, occupational exposures, and biological effects. A national survey indicated that approximately 1,200 workers are potentially exposed to sulfur tetrafluoride. Studies have indicated that sulfur tetrafluoride is highly toxic, irritating, and corrosive to skin, eyes and the respiratory system. Studies in rats showed that sulfur tetrafluoride at 19 parts per million was lethal to one of two rats exposed for 4 hours. A subchronic study showed that rats exposed to 4 parts per million for 4 hours/day for 10 days developed labored breathing, weakness and nasal discharge; after a 14 day recovery period, no significant pathological changes were seen on autopsy. No information was found on carcinogenicity, mutagenicity, or teratogenicity.

  4. The mammalian toxicological hazards of petroleum-derived substances: an overview of the petroleum industry response to the high production volume challenge program.

    PubMed

    McKee, Richard H; White, Russell

    2014-01-01

    Petroleum-derived substances are complex and composed of aliphatic (normal-, iso-, and cycloparaffins), olefinic, and/or aromatic constituents. Approximately 400 of these complex substances were evaluated as part of the US Environmental Protection Agency voluntary High Production Volume (HPV) Challenge program. The substances were separated into 13 groups (categories), and all available data were assessed. Toxicology testing was conducted as necessary to fully address the end points encompassed by the HPV initiative. In a broad sense, volatile hydrocarbons may cause acute central nervous system effects, and those that are liquids at room temperature pose aspiration hazards if taken into the lungs as liquids and may also cause skin irritation. Higher boiling substances may contain polycyclic aromatic constituents (PACs) that can be mutagenic and carcinogenic and may also cause developmental effects. Substances containing PACs can also cause target organ and developmental effects. The effects of aliphatic constituents include liver enlargement and/or renal effects in male rats via an α-2u-globulin-mediated process and, in some cases, small but statistically significant reductions in hematological parameters. Crude oils may contain other constituents, particularly sulfur- and nitrogen-containing compounds, which are removed during refining. Aside from these more generic considerations, some specific petroleum substances may contain unusually toxic constituents including benzene, 1,3-butadiene, and/or n-hexane, which should also be taken into account if present at toxicologically relevant levels.

  5. Toxicology research for precautionary decision-making and the role of Human & Experimental Toxicology.

    PubMed

    Grandjean, P

    2015-12-01

    A key aim of toxicology is the prevention of adverse effects due to toxic hazards. Therefore, the dissemination of toxicology research findings must confront two important challenges: one being the lack of information on the vast majority of potentially toxic industrial chemicals and the other being the strict criteria for scientific proof usually required for decision-making in regard to prevention. The present study ascertains the coverage of environmental chemicals in four volumes of Human & Experimental Toxicology and the presentation and interpretation of research findings in published articles. Links in SciFinder showed that the 530 articles published in four selected volumes between 1984 and 2014 primarily dealt with metals (126 links) and other toxicants that have received substantial attention in the past. Thirteen compounds identified by US authorities in 2006 as high-priority substances, for which toxicology documentation is badly needed, were not covered in the journal issues at all. When reviewing published articles, reliance on p values was standard, and non-significant findings were often called 'negative.' This tradition may contribute to the perceived need to extend existing research on toxic hazards that have already been well characterized. Several sources of bias towards the null hypothesis can affect toxicology research, but are generally not considered, thus adding to the current inclination to avoid false positive findings. In this regard, toxicology is particularly prone to bias because of the known paucity of false positives and, in particular, the existence of a vast number of toxic hazards which by default are considered innocuous due to lack of documentation. The Precautionary Principle could inspire decision-making on the basis of incomplete documentation and should stimulate a change in toxicology traditions and in toxicology research publication.

  6. Genetic toxicology: web resources.

    PubMed

    Young, Robert R

    2002-04-25

    Genetic toxicology is the scientific discipline dealing with the effects of chemical, physical and biological agents on the heredity of living organisms. The Internet offers a wide range of online digital resources for the field of Genetic Toxicology. The history of genetic toxicology and electronic data collections are reviewed. Web-based resources at US National Library of Medicine (NLM), including MEDLINE, PUBMED, Gateway, Entrez, and TOXNET, are discussed. Search strategies and Medical Subject Headings (MeSH) are reviewed in the context of genetic toxicology. The TOXNET group of databases are discussed with emphasis on those databases with genetic toxicology content including GENE-TOX, TOXLINE, Hazardous Substances Data Bank, Integrated Risk Information System, and Chemical Carcinogenesis Research Information System. Location of chemical information including chemical structure and linkage to health and regulatory information using CHEMIDPLUS at NLM and other databases is reviewed. Various government agencies have active genetic toxicology research programs or use genetic toxicology data to assist fulfilling the agency's mission. Online resources at the US Food and Drug Administration (FDA), the US Environmental Protection Agency (EPA), the National Institutes of Environmental Health Sciences, and the National Toxicology Program (NTP) are outlined. Much of the genetic toxicology for pharmaceuticals, industrial chemicals and pesticides that is performed in the world is regulatory-driven. Regulatory web resources are presented for the laws mandating testing, guidelines on study design, Good Laboratory Practice (GLP) regulations, and requirements for electronic data collection and reporting. The Internet provides a range of other supporting resources to the field of genetic toxicology. The web links for key professional societies and journals in genetic toxicology are listed. Distance education, educational media resources, and job placement services are also

  7. The potential role of earthworms in toxicity assessment of terrestrial hazardous waste sites

    SciTech Connect

    Goven, A.J.; Fitzpatrick, L.C.; Venables, B.J.

    1994-12-31

    Understanding the toxic potential and mechanisms of action of environmental xenobiotics is fundamental for assessing risk to public and environmental health. Current established protocols with earthworms focus primarily on defining the lethal effects of chemicals associated with soil contamination. Development of sublethal assays, until recently, has been largely ignored. Here the authors develop rationale for use of earthworms as a model organism for comprehensive assessment of risks to higher wildlife from contaminated soils and hazardous waste sites. They present a panel of lethal (LC/LD50`s) and sublethal measurement endpoint biomarkers, developed within the framework of the National Toxicology Program`s tiered immunotoxicity protocol for mice and according to published criteria for good measurement endpoints, that represent sensitive phylogenetically-conserved processes. Specifically the authors discuss immunosuppressive effects of terrestrial heavy metal and organic contamination on the innate, nonspecific and specific immune responses of earthworm, Lumbricus terrestris, coelomocytes in terms of total and differential cell counts, lysozyme activity, nitroblue tetrazolium dye reduction, phagocytic activity and secretary rosette formation. Findings indicate that sensitive phylogenetically conserved immune responses present in invertebrates can be used to assess or predict risk to wildlife from contaminated soils.

  8. Toxicological evaluation of Euterpe edulis: a potential superfruit to be considered.

    PubMed

    Felzenszwalb, Israel; da Costa Marques, Monica Regina; Mazzei, José L; Aiub, Claudia A F

    2013-08-01

    Superfruits have a high nutritional value due to their richness in nutrients, antioxidants, proven or potential health benefits and taste appeal. However, there are no scientific criteria for defining which fruits are superfruits. In Brazil, several palms have an edible palm heart, the best known and most widely appreciated of which is called Acai (Euterpe oleracea). Euterpe edulis Mart., commonly called jussara, is an evergreen species that grows in the rainforest. Having initially been consumed in the form of juice and pulp, they have since been incorporated as an ingredient in many foods. A risk assessment to identify adverse health effects is a prerequisite for taking forward the development of new drugs, cosmetics and foods. To make a toxicological evaluation of E. edulis, in the present work this prerequisite was met by an interdisciplinary network that performed mass spectroscopy analyses, blood biochemistry, genotoxicity, bacterial reverse mutation and cytotoxicity assays. Positive mutagenicity results were detected for Salmonella typhimurium TA97 at low doses, and positive results were also obtained for the mammalian erythrocyte micronucleus assay, indicating that the pulp of E. edulis contains compounds with the capacity to induce mutagenicity and clastogenic/aneugenic effects. Copyright © 2013 Elsevier Ltd. All rights reserved.

  9. Molecular Insights into the Potential Toxicological Interaction of 2-Mercaptothiazoline with the Antioxidant Enzyme—Catalase

    PubMed Central

    Huang, Zhenxing; Huang, Ming; Mi, Chenyu; Wang, Tao; Chen, Dong; Teng, Yue

    2016-01-01

    2-mercaptothiazoline (2-MT) is widely used in many industrial fields, but its residue is potentially harmful to the environment. In this study, to evaluate the biological toxicity of 2-MT at protein level, the interaction between 2-MT and the pivotal antioxidant enzyme—catalase (CAT) was investigated using multiple spectroscopic techniques and molecular modeling. The results indicated that the CAT fluorescence quenching caused by 2-MT should be dominated by a static quenching mechanism through formation of a 2-MT/CAT complex. Furthermore, the identifications of the binding constant, binding forces, and the number of binding sites demonstrated that 2-MT could spontaneously interact with CAT at one binding site mainly via Van der Waals’ forces and hydrogen bonding. Based on the molecular docking simulation and conformation dynamic characterization, it was found that 2-MT could bind into the junctional region of CAT subdomains and that the binding site was close to enzyme active sites, which induced secondary structural and micro-environmental changes in CAT. The experiments on 2-MT toxicity verified that 2-MT significantly inhibited CAT activity via its molecular interaction, where 2-MT concentration and exposure time both affected the inhibitory action. Therefore, the present investigation provides useful information for understanding the toxicological mechanism of 2-MT at the molecular level. PMID:27537873

  10. The operating room: architectural conditions and potential hazards.

    PubMed

    Koneczny, Sonja

    2009-01-01

    Ergonomics is still not fully implemented in the design of operation rooms (ORs). The OR staff has to deal with various ergonomic deficiencies which may be associated with potential hazards for the patient and/or the OR team.Three surveys were conducted among German OR staff at major conferences. Two of them dealt with the working conditions in the OR and were conducted among surgeons and OR nurses. The third survey queried OR nurses about the electrical safety in the OR.In addition, a specially developed checklist was used to evaluate the work place OR in five German OR units and the staff of these OR units were queried with questionnaires adapted from the surveys. For this article a few of the deficiencies found in the ORs were chosen to serve as examples for the plethora of results gathered.Findings showed that there was a high potential for ergonomic improvement and therefore an increase in safety and comfort. Many of these deficiencies may be eased by simple means such as the reduction of the number of different devices and mandatory training in the use of the devices since device operation is one of the main causes leading to potential hazards in the OR. Other deficiencies, such as the cable routing in the OR, require more extensive intervention and/or the implementation of new techniques, for example the "wireless" OR. All these deficiencies demonstrate the need for better implementation of ergonomics into the OR and for individual solutions, as there is no such thing as an 'one-size-fits-all' solution for OR units.

  11. Prevalidation of potential protein biomarkers in toxicology using iTRAQ reagent technology.

    PubMed

    Glückmann, Matthias; Fella, Kerstin; Waidelich, Dietmar; Merkel, Dietrich; Kruft, Volker; Kramer, Peter-Jürgen; Walter, Yvonne; Hellmann, Jürgen; Karas, Michael; Kröger, Michaela

    2007-05-01

    Today, toxicoproteomics still relies mainly on 2-DE followed by MS for detection and identification of proteins, which might characterize a certain state of disease, indicate toxicity or even predict carcinogenicity. We utilized the classical 2-DE/MS approach for the evaluation of early protein biomarkers which are predictive for chemically induced hepatocarcinogenesis in rats. We were able to identify statistically significantly deregulated proteins in N-nitrosomorpholine exposed rat liver tissue. Based on literature data, biological relevance in the early molecular process of hepatocarcinogenicity could be suggested for most of these potential biomarkers. However, in order to ensure reliable results and to create the prerequisites necessary for integration in routine toxicology studies in the future, these protein expression patterns need to be prevalidated using independent technology platforms. In the current study, we evaluated the usefulness of iTRAQ reagent technology (Applied Biosystems, Framingham, USA), a recently introduced MS-based protein quantitation method, for verification of the 2-DE/MS biomarkers. In summary, the regulation of 26 2-DE/MS derived protein biomarkers could be verified. Proteins like HSP 90-beta, annexin A5, ketohexokinase, N-hydroxyarylamine sulfotransferase, ornithine aminotransferase, and adenosine kinase showed highly comparable fold changes using both proteomic quantitation strategies. In addition, iTRAQ analysis delivered further potential biomarkers with biological relevance to the processes of hepatocarcinogenicity: e.g. placental form of glutathione S-transferase (GST-P), carbonic anhydrase, and aflatoxin B1 aldehyde reductase. Our results show both the usefulness of iTRAQ reagent technology for biomarker prevalidation as well as for identification of further potential marker proteins, which are indicative for liver hepatocarcinogenicity.

  12. Toxicological benchmarks for screening potential contaminants of concern for effects on terrestrial plants. Environmental Restoration Program

    SciTech Connect

    Suter, G.W. II; Will, M.E.; Evans, C.

    1993-09-01

    One of the initial stages in ecological risk assessment for hazardous waste sites is the screening of contaminants to determine which of them are worthy of further consideration as ``contaminants of potential concern.`` This process is termed ``contaminant screening.`` It is performed by comparing measured ambient concentrations of chemicals to benchmark concentrations. Currently, no standard benchmark concentrations exist for assessing contaminants in soil with respect to their toxicity to plants. This report presents a standard method for deriving benchmarks for this purpose (phytotoxicity benchmarks), a set of data concerning effects of chemicals in soil or soil solution on plants, and a set of phytotoxicity benchmarks for 34 chemicals potentially associated with US Department of Energy (DOE) sites. Chemicals that are found in soil at concentrations exceeding both the phytotoxicity benchmark and the background concentration for the soil type should be considered contaminants of potential concern. The purpose of this report is to present plant toxicity data and discuss their utility as benchmarks for determining the hazard to terrestrial plants caused by contaminants in soil. Benchmarks are provided for soils and solutions.

  13. Potential hazards from future volcanic eruptions in California

    USGS Publications Warehouse

    Miller, C. Dan

    1989-01-01

    More than 500 volcanic vents have been identified in the State of California. At least 76 of these vents have erupted, some repeatedly, during the last 10,000 years. Past volcanic activity has ranged in scale and type from small rhyolitic and basaltic eruptions through large catastrophic rhyolitic eruptions. Sooner or later, volcanoes in California will erupt again, and they could have serious impacts on the health and safety of the State\\'s citizens as well as on its economy. This report describes the nature and probable distribution of potentially hazardous volcanic phenomena and their threat to people and property. It includes hazard-zonation maps that show areas relatively likely to be affected by future eruptions in California. The potentially more hazardous eruptions in the State are those that involve explosive eruption of large volumes of silicic magma. Such eruptions could occur at vents in as many as four areas in California. They could eject pumice high into the atmosphere above the volcano, produce destructive blasts, avalanches, or pyroclastic flows that reach distances of tens of kilometers from a vent, and produce mudflows and floods that reach to distances of hundreds of kilometers. Smaller eruptions produce similar, but less severe and less extensive, phenomena. Hazards are greatest close to a volcanic vent; the slopes on or near a volcano, and valleys leading away from it, are affected most often and most severely by such eruptions. In general, risk from volcanic phenomena decreases with increasing distance from a vent and, for most flowage processes, with increasing height above valley floors or fan surfaces. Tephra (ash) from explosive eruptions can affect wide areas downwind from a vent. In California, prevailing winds cause the 180-degree sector east of the volcano to be affected most often and most severely. Risk to life from ashfall decreases rapidly with increasing distance from a vent, but thin deposits of ash could disrupt communication

  14. From forensic toxicology to biological chemistry: Normal arsenic and the hazards of sensitivity during the nineteenth century.

    PubMed

    Bertomeu-Sánchez, José Ramón

    2016-06-01

    This paper reviews the cultural meanings, social uses and circulations of arsenic in different legal, medical and popular settings. The focus is on nineteenth-century France. In the first section, I review the advent of the Marsh test for arsenic, which is commonly regarded as a milestone in the history of toxicology. I claim that the high sensitivity of the Marsh test introduced puzzling problems for forensic doctors, the most disturbing one being the so-called 'normal arsenic.' I reconstruct early research on normal arsenic and the ensuing controversies in courts, academies and salons. A report from the French Academy of Science converted normal arsenic from a big discovery to an experimental mistake. In the next section, I study how these disturbing conclusions were perceived by toxicologists all over Europe and how normal arsenic disappeared from view by the middle of the nineteenth century. Finally, I review the return of normal arsenic thanks to Armand Gautier and Gabriel Bertrand, who introduced an innovative research framework and so prompted the displacement of arsenic from criminal toxicology to pharmacology and nutrition science. The last section will also show that the issue of normal arsenic was recaptured in public debates concerning criminal poisoning at the beginning of the twentieth century. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Polymer degradation and ultrafine particles - Potential inhalation hazards for astronauts

    NASA Technical Reports Server (NTRS)

    Ferin, J.; Oberdoerster, G.

    1992-01-01

    To test the hypothesis that exposure to ultrafine particles results in an increased interstiatilization of the particles which is accompanied by an acute pathological inflammation, rats were exposed to titanium dioxide (TiO2) particles by intratracheal instillation and by inhalation. Both acute intratracheal instillation and subchronic inhalation studies on rats show that ultrafine TiO2 particles access the pulmonary interstitium to a larger extent than fine particles and that they elicit an inflammatory response as indicated by PMN increase in lavaged cells. The release of ultrafine particles into the air of an enclosed environment from a thermodegradation event or from other sources is a potential hazard for astronauts. Knowing the mechanisms of action is a prerequisite for technical or medical countermeasures.

  16. Eight Potentially Hazardous Near Earth Asteroids: Characterization and Threat Assessment

    NASA Astrophysics Data System (ADS)

    Hicks, Stacy; Carini, Michael T.

    2017-01-01

    We present the initial results of a study of eight potentially hazardous asteroids identified in conjunction with NASA’s OSIRIS REX Mission and observed via the Target Asteroid Project. This study will include a characterization of these asteroids’ orbits and physical characteristics as well as a threat assessment. Using images obtained by the target asteroid project, light curves for each asteroid were constructed and subsequent analysis of the light curves was used to determine the rotation period of the asteroid and its size. Knowledge of the size and composition of the asteroid are the two critical parameters used in assessing the severity of the threat an asteroid poses. Using the determined characteristics for each target asteroid, risk assessment and impact scenario modeling are undertaken to determine the effects of an impact event specific to each target.

  17. Polymer degradation and ultrafine particles - Potential inhalation hazards for astronauts

    NASA Technical Reports Server (NTRS)

    Ferin, J.; Oberdoerster, G.

    1992-01-01

    To test the hypothesis that exposure to ultrafine particles results in an increased interstiatilization of the particles which is accompanied by an acute pathological inflammation, rats were exposed to titanium dioxide (TiO2) particles by intratracheal instillation and by inhalation. Both acute intratracheal instillation and subchronic inhalation studies on rats show that ultrafine TiO2 particles access the pulmonary interstitium to a larger extent than fine particles and that they elicit an inflammatory response as indicated by PMN increase in lavaged cells. The release of ultrafine particles into the air of an enclosed environment from a thermodegradation event or from other sources is a potential hazard for astronauts. Knowing the mechanisms of action is a prerequisite for technical or medical countermeasures.

  18. Potential occupational health hazards in the microelectronics industry.

    PubMed

    LaDou, J

    1983-02-01

    The microelectronics industry is a major user of a wide variety of chemicals and other toxic materials. In the recent past semiconductor manufacturers have located in many countries and brought a new set of challenging clinical problems to occupational physicians. California, an area with a significant history in the statistical study of health and safety in the microelectronics industry, presents some evidence of potential health hazards in the semiconductor manufacturing process. The Semiconductor Industry Study done in California in 1981 explains the application of many toxic materials in the semiconductor manufacturing process, including a variety of solvents, acids, and metals such as arsenic. The Study documents the extensive use of dopant gases, primarily arsine, phosphine and diborane. Further study is necessary to assure the health and safety of microelectronics workers, particularly in the application of dopant gases.

  19. ICPP radiological and toxicological sabotage analysis

    SciTech Connect

    Kubiak, V.R.; Mortensen, F.G.

    1995-10-01

    In June of 1993, the Department of Energy (DOE) issued Notice 5630.3A, {open_quotes}Protection of Departmental Facilities Against Radiological and Toxicological Sabotage,{close_quotes} which states that all significant radiological and toxicological hazards at Department facilities must be examined for potential sabotage. This analysis has been completed at the Idaho Chemical Processing Plant (ICPP). The ICPP radiological and toxicological hazards include spent government and commercial fuels, Special Nuclear Materials (SNM), high-level liquid wastes, high-level solid wastes, and process and decontamination chemicals. The analysis effort included identification and assessment of quantities of hazardous materials present at the facility; identification and ranking of hazardous material targets; development of worst case scenarios detailing possible sabotage actions and hazard releases; performance of vulnerability assessments using table top and computer methodologies on credible threat targets; evaluation of potential risks to the public, workers, and the environment; evaluation of sabotage risk reduction options; and selection of cost effective prevention and mitigation options.

  20. Differences in the Toxicological Potential of 2D versus Aggregated Molybdenum Disulfide in the Lung.

    PubMed

    Wang, Xiang; Mansukhani, Nikhita D; Guiney, Linda M; Ji, Zhaoxia; Chang, Chong Hyun; Wang, Meiying; Liao, Yu-Pei; Song, Tze-Bin; Sun, Bingbing; Li, Ruibin; Xia, Tian; Hersam, Mark C; Nel, André E

    2015-10-01

    2D molybdenum disulfide (MoS2 ) has distinct optical and electronic properties compared to aggregated MoS2 , enabling wide use of these materials for electronic and biomedical applications. However, the hazard potential of MoS2 has not been studied extensively. Here, a comprehensive analysis of the pulmonary hazard potential of three aqueous suspended forms of MoS2 -aggregated MoS2 (Agg-MoS2 ), MoS2 exfoliated by lithiation (Lit-MoS2 ), and MoS2 dispersed by Pluronic F87 (PF87-MoS2 )-is presented. No cytotoxicity is detected in THP-1 and BEAS-2B cell lines. However, Agg-MoS2 induces strong proinflammatory and profibrogenic responses in vitro. In contrast, Lit- and PF87-MoS2 have little or no effect. In an acute toxicity study in mice, Agg-MoS2 induces acute lung inflammation, while Lit-MoS2 and PF87-MoS2 have little or no effect. In a subchronic study, there is no evidence of pulmonary fibrosis in response to all forms of MoS2 . These data suggest that exfoliation attenuates the toxicity of Agg-MoS2 , which is an important consideration toward the safety evaluation and use of nanoscale MoS2 materials for industrial and biological applications. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity.

    PubMed

    Harper, Bryan; Thomas, Dennis; Chikkagoudar, Satish; Baker, Nathan; Tang, Kaizhi; Heredia-Langner, Alejandro; Lins, Roberto; Harper, Stacey

    The integration of rapid assays, large datasets, informatics, and modeling can overcome current barriers in understanding nanomaterial structure-toxicity relationships by providing a weight-of-the-evidence mechanism to generate hazard rankings for nanomaterials. Here, we present the use of a rapid, low-cost assay to perform screening-level toxicity evaluations of nanomaterials in vivo. Calculated EZ Metric scores, a combined measure of morbidity and mortality in developing embryonic zebrafish, were established at realistic exposure levels and used to develop a hazard ranking of diverse nanomaterial toxicity. Hazard ranking and clustering analysis of 68 diverse nanomaterials revealed distinct patterns of toxicity related to both the core composition and outermost surface chemistry of nanomaterials. The resulting clusters guided the development of a surface chemistry-based model of gold nanoparticle toxicity. Our findings suggest that risk assessments based on the size and core composition of nanomaterials alone may be wholly inappropriate, especially when considering complex engineered nanomaterials. Research should continue to focus on methodologies for determining nanomaterial hazard based on multiple sub-lethal responses following realistic, low-dose exposures, thus increasing the availability of quantitative measures of nanomaterial hazard to support the development of nanoparticle structure-activity relationships.

  2. Functional Genomic Screening Approaches in Mechanistic Toxicology and Potential Future Applications of CRISPR-Cas9

    PubMed Central

    Shen, Hua; McHale, Cliona M.; Smith, Martyn T; Zhang, Luoping

    2015-01-01

    Characterizing variability in the extent and nature of responses to environmental exposures is a critical aspect of human health risk assessment. Chemical toxicants act by many different mechanisms, however, and the genes involved in adverse outcome pathways (AOPs) and AOP networks are not yet characterized. Functional genomic approaches can reveal both toxicity pathways and susceptibility genes, through knockdown or knockout of all non-essential genes in a cell of interest, and identification of genes associated with a toxicity phenotype following toxicant exposure. Screening approaches in yeast and human near-haploid leukemic KBM7 cells, have identified roles for genes and pathways involved in response to many toxicants but are limited by partial homology among yeast and human genes and limited relevance to normal diploid cells. RNA interference (RNAi) suppresses mRNA expression level but is limited by off-target effects (OTEs) and incomplete knockdown. The recently developed gene editing approach called clustered regularly interspaced short palindrome repeats-associated nuclease (CRISPR)-Cas9, can precisely knock-out most regions of the genome at the DNA level with fewer OTEs than RNAi, in multiple human cell types, thus overcoming the limitations of the other approaches. It has been used to identify genes involved in the response to chemical and microbial toxicants in several human cell types and could readily be extended to the systematic screening of large numbers of environmental chemicals. CRISPR-Cas9 can also repress and activate gene expression, including that of non-coding RNA, with near-saturation, thus offering the potential to more fully characterize AOPs and AOP networks. Finally, CRISPR-Cas9 can generate complex animal models in which to conduct preclinical toxicity testing at the level of individual genotypes or haplotypes. Therefore, CRISPR-Cas9 is a powerful and flexible functional genomic screening approach that can be harnessed to provide

  3. High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)

    PubMed Central

    Marescotti, Diego; Gonzalez Suarez, Ignacio; Acali, Stefano; Johne, Stephanie; Laurent, Alexandra; Frentzel, Stefan; Hoeng, Julia; Peitsch, Manuel C.

    2016-01-01

    Cigarette smoke (CS) is a major risk factor for cardiovascular and lung diseases. Because CS is a complex aerosol containing more than 7,000 chemicals1 it is challenging to assess the contributions of individual constituents to its overall toxicity. Toxicological profiles of individual constituents as well as mixtures can be however established in vitro, by applying high through-put screening tools, which enable the profiling of Harmful and Potentially Harmful Constituents (HPHCs) of tobacco smoke, as defined by the U.S. Food and Drug Administration (FDA).2 For an initial assessment, an impedance-based instrument was used for a real-time, label-free assessment of the compound's toxicity. The instrument readout relies on cell adhesion, viability and morphology that all together provide an overview of the cell status. A dimensionless parameter, named cell index, is used for quantification. A set of different staining protocols was developed for a fluorescence imaging-based investigation and a HCS platform was used to gain more in-depth information on the kind of cytotoxicity elicited by each HPHC. Of the 15 constituents tested, only five were selected for HCS-based analysis as they registered a computable LD50 (< 20 mM). These included 1-aminonaphtalene, Arsenic (V), Chromium (VI), Crotonaldehyde and Phenol. Based on their effect in the HCS, 1-aminonaphtalene and Phenol could be identified to induce mitochondrial dysfunction, and, together with Chromium (VI) as genotoxic based on the increased histone H2AX phosphorylation. Crotonaldehyde was identified as an oxidative stress inducer and Arsenic as a stress kinase pathway activator. This study demonstrates that a combination of impedance-based and HCS technologies provides a robust tool for in vitro assessment of CS constituents. PMID:27228213

  4. Toxicological benchmarks for screening potential contaminants of concern for effects on sediment-associated biota. Environmental Restoration Program ESD Publication 4107

    SciTech Connect

    Hull, R.N.; Suter, G.W. II

    1993-08-01

    Because a hazardous waste site may contain hundreds of chemicals, it is important to screen contaminants of concern for the ecological risk assessment. Often this screening is done as part of a Screening Assessment, the purpose of which is to evaluate the available data, identify data gaps, and screen potential contaminants of concern. Screening may be accomplished by using a set of toxicological benchmarks. These benchmarks are helpful in determining whether contaminants warrant further assessment or are at a level that requires no further attention. If a chemical concentration or the reported detection limit exceeds a proposed lower benchmark, more analysis is needed to determine the hazards posed by that chemical. If, however, the chemical concentration falls below the lower benchmark value, the chemical may be eliminated from further study. This report briefly describes three categories of approaches to the development of sediment quality benchmarks. These approaches are based on analytical chemistry, toxicity test results, and field survey data. A fourth integrative approach incorporates all three types of data.

  5. Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity

    DOE PAGES

    Harper, Bryan; Thomas, Dennis G.; Chikkagoudar, Satish; ...

    2015-06-04

    The integration of rapid assays, large data sets, informatics and modeling can overcome current barriers in understanding nanomaterial structure-toxicity relationships by providing a weight-of-the-evidence mechanism to generate hazard rankings for nanomaterials. Here we present the use of a rapid, low-cost assay to perform screening-level toxicity evaluations of nanomaterials in vivo. Calculated EZ Metric scores, a combined measure of morbidity and mortality, were established at realistic exposure levels and used to develop a predictive model of nanomaterial toxicity. Hazard ranking and clustering analysis of 68 diverse nanomaterials revealed distinct patterns of toxicity related to both core composition and outermost surface chemistrymore » of nanomaterials. The resulting clusters guided the development of a predictive model of gold nanoparticle toxicity to embryonic zebrafish. In addition, our findings suggest that risk assessments based on the size and core composition of nanomaterials alone may be wholly inappropriate, especially when considering complex engineered nanomaterials. These findings reveal the need to expeditiously increase the availability of quantitative measures of nanomaterial hazard and broaden the sharing of that data and knowledge to support predictive modeling. In addition, research should continue to focus on methodologies for developing predictive models of nanomaterial hazard based on sub-lethal responses to low dose exposures.« less

  6. Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity

    SciTech Connect

    Harper, Bryan; Thomas, Dennis G.; Chikkagoudar, Satish; Baker, Nathan A.; Tang, Kaizhi; Heredia-Langner, Alejandro; Lins, Roberto D.; Harper, Stacey

    2015-06-04

    The integration of rapid assays, large data sets, informatics and modeling can overcome current barriers in understanding nanomaterial structure-toxicity relationships by providing a weight-of-the-evidence mechanism to generate hazard rankings for nanomaterials. Here we present the use of a rapid, low-cost assay to perform screening-level toxicity evaluations of nanomaterials in vivo. Calculated EZ Metric scores, a combined measure of morbidity and mortality, were established at realistic exposure levels and used to develop a predictive model of nanomaterial toxicity. Hazard ranking and clustering analysis of 68 diverse nanomaterials revealed distinct patterns of toxicity related to both core composition and outermost surface chemistry of nanomaterials. The resulting clusters guided the development of a predictive model of gold nanoparticle toxicity to embryonic zebrafish. In addition, our findings suggest that risk assessments based on the size and core composition of nanomaterials alone may be wholly inappropriate, especially when considering complex engineered nanomaterials. These findings reveal the need to expeditiously increase the availability of quantitative measures of nanomaterial hazard and broaden the sharing of that data and knowledge to support predictive modeling. In addition, research should continue to focus on methodologies for developing predictive models of nanomaterial hazard based on sub-lethal responses to low dose exposures.

  7. New potentials of laser scanning in landslide hazard assessments

    NASA Astrophysics Data System (ADS)

    Bell, Rainer; Petschko, Helene

    2010-05-01

    The increasing availability of airborne (ALS) and terrestrial (TLS) laser scanning data in geomorphological studies has started to lead to a "revolution in geomorphology". Laser scanning data offers new details not only on vegetation surface but also on earth surface and subsequently provides new insights into geomorphological forms and respective past and present processes which created these forms. Within this study, mainly the potential of ALS in regional landslide hazard assessments is addressed. The starting point for each regional landslide hazard assessment should be an excellent landslide inventory, which often is not available at the beginning of such an assessment. Usually, landslide inventories were set up by e.g. field mapping, digitizing of landslide information from geological or geomorphological maps or interpretation of aerial photos. High resolution digital terrain models (DTM) derived from ALS provide new and excellent data sources for more efficiently mapping landslides. Very accurate landslide inventories can be mapped regarding especially the location and completeness of landslides by analysing ALS DTM's. However, there are quite some limitations involved, since past landslides might be invisible in the DTM due to natural erosion or human impact. Other landslides might be too young to be captured in the DTM. New challenges arise if the study area gets too large. Quite often, resources on time and manpower are limited so that not all landslides can be mapped. Thus, new strategies for efficient landslide mapping and preparation of sufficient complete inventories must be developed beside activities to automate landslide mapping from DTM's. Since landslide structures are modified over time, relative age might be estimated from the freshness of the structures itself. However, these are strongly dependent on the type of land use. Whereas they are preserved under forest, they change more rapidly e.g. in agricultural areas. The challenge is, if the age

  8. Oligopyrrole Macrocycles: Receptors and Chemosensors for Potentially Hazardous Materials

    PubMed Central

    2011-01-01

    Oligopyrroles represent a diverse class of molecular receptors that have been utilized in a growing number of applications. Recently, these systems have attracted interest as receptors and chemosensors for hazardous materials, including harmful anionic species, high-valent actinide cations, and nitroaromatic explosives. These versatile molecular receptors have been used to develop rudimentary colorimetric and fluorimetric assays for hazardous materials. PMID:21465591

  9. Occupational toxicology in Mexico: current status and the potential use of molecular studies to evaluate chemical exposure.

    PubMed

    Muñoz, Balam; Albores, Arnulfo

    2011-11-01

    Occupational toxicology is of considerable concern for several world organizations including the International Labour Organization, the World Health Organization and the International Commission for Occupational Health and, in Latin America, the Pan American Health Organization. The countries of this Region, including Mexico, own manufacturing, chemical, and petrochemical industries that employ thousands workers who are continually exposed to hazardous chemicals such as solvents, particles and exhaust fumes, many of which are very complex mixtures. Traditionally, physicians have used biochemical analyses to assess the damage caused by chronic chemical exposure. Presently, recent advances in molecular biology may offer tools to perform more thorough and precise evaluations on worker health damage, risk and current health status. In this review, we present a perspective of occupational toxicology in Mexico, as an example for Latin America and developing countries. Moreover, we summarize current reports about occupational disease associated with chemical exposure, and we present an array of molecular studies proposed for the analysis and diagnosis of workers related with industry and the relevance of including molecular biology testing to complement traditional occupational medical assays in order to improve occupational health. We conclude that developing countries, e.g., Mexico, should improve work environment standards by using new technical approaches that will result in more reliable and precise data to design better health policy strategies.

  10. Cytotoxic, phytotoxic, and mutagenic appraisal to ascertain toxicological potential of particulate matter emitted from automobiles.

    PubMed

    Anwar, Khaleeq; Ejaz, Sohail; Ashraf, Muhammad; Altaf, Imran; Anjum, Aftab Ahmad

    2013-07-01

    Vehicular air pollution is a mounting health issue of the modern age, particularly in urban populations of the developing nations. Auto-rickshaws are not considered eco-friendly as to their inefficient engines producing large amount of particulate matter (PM), thus posing significant environmental threat. The present study was conducted to ascertain the cytotoxic, phytotoxic, and mutagenic potential of PM from gasoline-powered two-stroke auto-rickshaws (TSA) and compressed natural gas-powered four-stroke auto-rickshaws (FSA). Based on the increased amount of aluminum quantified during proton-induced X-ray emission analysis of PM from TSA and FSA, different concentrations of aluminum sulfate were also tested to determine its eco-toxicological potential. The MTT assay demonstrated significant (p < 0.001) dose-dependent cytotoxic effects of different concentrations of TSA, FSA, and aluminum sulfate on BHK-21 cell line. LC50 of TSA, FSA, and aluminum sulfate was quantified at 16, 11, and 23.8 μg/ml, respectively, establishing PM from FSA, a highly cytotoxic material. In case of phytotoxicity screening using Zea mays, the results demonstrated that all three tested materials were equally phytotoxic at higher concentrations producing significant reduction (p < 0.001) in seed germination. Aluminum sulfate proved to be a highly phytotoxic agent even at its lowest concentration. Mutagenicity was assessed by fluctuation Salmonella reverse mutation assay adopting TA100 and TA98 mutant strains with (+S9) and without (-S9) metabolic activation. Despite the fact that different concentrations of PM from both sources, i.e., TSA and FSA were highly mutagenic (p < 0.001) even at lower concentrations, the mutagenic index was higher in TSA. Data advocate that all tested materials are equally ecotoxic, and if the existing trend of atmospheric pollution by auto-rickshaws is continued, airborne heavy metals will seriously affect the normal growth of local inhabitants and

  11. Polymer degradation and ultrafine particles: Potential inhalation hazards for astronauts

    NASA Astrophysics Data System (ADS)

    Ferin, J.; Oberdörster, G.

    When Teflon is heated the developing fumes produce in exposed humans an influenza-like syndrome (polymer fume fever) or also severe toxic effects like pulmonary edema, pneumonitis and death. The decomposition products and the resulting health effects are temperature-dependent. The toxic effects seem to be related to the ultrafine particulate fraction of the fume. To test the hypothesis that exposure to ultrafine particles results in an increased interstitialization of the particles which is accompanied by an acute pathological inflammation, rats were exposed to titanium dioxide (TiO 2) particles by intratracheal instillation and by inhalation. Both acute intratracheal instillation and subchronic inhalation studies on rats show that ultrafine TiO 2 particles (˜20 nm diameter) access the pulmonary interstitium to a larger extent than fine particles (˜250 nm diameter) and that they elicit an inflammatory response as indicated by PMN increase in lavaged cells. The release of ultrafine particles into the air of an enclosed environment from a thermodegradation event or from other sources is a potential hazard for astronauts. Knowing the mechanisms of action is a prerequisite for technical or medical countermeasures.

  12. Toxicological Benchmarks for Screening Potential Contaminants of Concern for Effects on Terrestrial Plants

    SciTech Connect

    Suter, G.W. II

    1993-01-01

    One of the initial stages in ecological risk assessment for hazardous waste sites is screening contaminants to determine which of them are worthy of further consideration as contaminants of potential concern. This process is termed contaminant screening. It is performed by comparing measured ambient concentrations of chemicals to benchmark concentrations. Currently, no standard benchmark concentrations exist for assessing contaminants in soil with respect to their toxicity to plants. This report presents a standard method for deriving benchmarks for this purpose (phytotoxicity benchmarks), a set of data concerning effects of chemicals in soil or soil solution on plants, and a set of phytotoxicity benchmarks for 38 chemicals potentially associated with United States Department of Energy (DOE) sites. In addition, background information on the phytotoxicity and occurrence of the chemicals in soils is presented, and literature describing the experiments from which data were drawn for benchmark derivation is reviewed. Chemicals that are found in soil at concentrations exceeding both the phytotoxicity benchmark and the background concentration for the soil type should be considered contaminants of potential concern.

  13. Toxicological benchmarks for screening potential contaminants of concern for effects on terrestrial plants: 1994 revision

    SciTech Connect

    Will, M.E.; Suter, G.W. II

    1994-09-01

    One of the initial stages in ecological risk assessment for hazardous waste sites is screening contaminants to determine which of them are worthy of further consideration as contaminants of potential concern. This process is termed contaminant screening. It is performed by comparing measured ambient concentrations of chemicals to benchmark concentrations. Currently, no standard benchmark concentrations exist for assessing contaminants in soil with respect to their toxicity to plants. This report presents a standard method for deriving benchmarks for this purpose (phytotoxicity benchmarks), a set of data concerning effects of chemicals in soil or soil solution on plants, and a set of phytotoxicity benchmarks for 38 chemicals potentially associated with United States Department of Energy (DOE) sites. In addition, background information on the phytotoxicity and occurrence of the chemicals in soils is presented, and literature describing the experiments from which data were drawn for benchmark derivation is reviewed. Chemicals that are found in soil at concentrations exceeding both the phytotoxicity benchmark and the background concentration for the soil type should be considered contaminants of potential concern.

  14. Systems toxicology.

    PubMed

    Hartung, Thomas; van Vliet, Erwin; Jaworska, Joanna; Bonilla, Leo; Skinner, Nigel; Thomas, Russell

    2012-01-01

    The need for a more mechanistic understanding of the ways in which chemicals modulate biological pathways is urgent if we are to identify and better assess safety issues relating to a wide range of substances developed by the pharmaceutical, chemical, agri-bio, and cosmetic industries. Omics technologies provide a valuable opportunity to refine existing methods and provide information for so-called integrated testing strategies via the creation of signatures of toxicity. By mapping these signatures to underlying pathways of toxicity, some of which have been identified by toxicologists over the last few decades, and bringing them together with pathway information determined from biochemistry and molecular biology, a "systems toxicology" approach will enable virtual experiments to be conducted that can improve the prediction of hazard and the assessment of compound toxicity.

  15. Evaluation of Equipment Vulnerability and Potential Shock Hazards. [carbon fibers

    NASA Technical Reports Server (NTRS)

    Taback, I.

    1980-01-01

    The vulnerability of electric equipment to carbon fibers released from aircraft accidents is investigated and the parameters affecting vulnerability are discussed. The shock hazard for a hypothetical set of accidents is computed.

  16. Could feeding habit and migratory behaviour be the causes of different toxicological hazard to cetaceans of Gulf of California (Mexico)?

    PubMed

    Fossi, M C; Panti, C; Marsili, L; Maltese, S; Coppola, D; Jimenez, B; Muñoz-Arnanz, J; Finoia, M G; Rojas-Bracho, L; Urban, R J

    2014-12-01

    In this work, a suite of diagnostic biomarkers was applied to seven cetacean species to evaluate the role of the feeding habits and migratory behavior in the toxicological status of these species from the Gulf of California, Mexico. We investigate the interspecific differences in cytochrome P450 1A1 and 2B (CYP1A1 and CYP2B, respectively), aryl hydrocarbon receptor and E2F transcription factor 1 and the contaminants levels [organochlorine compounds, polybrominated diphenyl ethers (PBDEs) and polycyclic aromatic hydrocarbons (PAHs)] in four odontocete species (common bottlenose dolphin, long-beaked common dolphin, sperm whale and killer whale) and three mysticete species (blue whale, fin whale, and Bryde's whale) using skin biopsy. Differences in contaminant levels and molecular biomarker responses between the odontocete and mysticete species have been pointed out. The canonical discriminant analysis on principal component analysis factors, performed to reveal clustering variables, shows that odontocete are characterised by the highest levels of lipophilic contaminants compared to the mysticete, with the highest levels of polychlorinated biphenyls, dichlorodiphenyltrichloroethanes and PBDEs detected in killer whale and the lowest levels in Bryde's whale. The biomarker data show interspecific differences amongst the seven species, revealing highest CYP1A and CYP2B protein levels in the mysticete fish-eating species (Bryde's whale). In conclusion, three main factors seem to regulate the biomarker responses in these species: (a) the inductive ability of persistent organic pollutants and PAHs; (b) the different evolutionary process of the two CYPs related to the different feeding habits of the species; (c) the migratory/resident behaviour of the mysticete species in this area.

  17. History of wildlife toxicology.

    PubMed

    Rattner, Barnett A

    2009-10-01

    The field of wildlife toxicology can be traced to the late nineteenth and early twentieth centuries. Initial reports included unintentional poisoning of birds from ingestion of spent lead shot and predator control agents, alkali poisoning of waterbirds, and die-offs from maritime oil spills. With the advent of synthetic pesticides in the 1930s and 1940s, effects of DDT and other pesticides were investigated in free-ranging and captive wildlife. In response to research findings in the US and UK, and the publication of Silent Spring in 1962, public debate on the hazards of pollutants arose and national contaminant monitoring programs were initiated. Shortly thereafter, population-level effects of DDT on raptorial and fish-eating birds were documented, and effects on other species (e.g., bats) were suspected. Realization of the global nature of organochlorine pesticide contamination, and the discovery of PCBs in environmental samples, launched long-range studies in birds and mammals. With the birth of ecotoxicology in 1969 and the establishment of the Society of Environmental Toxicology and Chemistry in 1979, an international infrastructure began to emerge. In the 1980s, heavy metal pollution related to mining and smelting, agrichemical practices and non-target effects, selenium toxicosis, and disasters such as Chernobyl and the Exxon Valdez dominated the field. Biomarker development, endocrine disruption, population modeling, and studies with amphibians and reptiles were major issues of the 1990s. With the turn of the century, there was interest in new and emerging compounds (pharmaceuticals, flame retardants, surfactants), and potential population-level effects of some compounds. Based upon its history, wildlife toxicology is driven by chemical use and misuse, ecological disasters, and pollution-related events affecting humans. Current challenges include the need to more thoroughly estimate and predict exposure and effects of chemical-related anthropogenic

  18. The Potentials Of Gnss-R For Sea Hazard Monitoring

    NASA Astrophysics Data System (ADS)

    Clarizia, Maria Paola; Toffoli, Alessandro

    2013-04-01

    GNSS-Reflectometry represents a new and innovative approach for ocean remote sensing. This technique exploits signals of opportunity from GNSS constellations (i.e. GPS, Glonass, Galileo etc.), reflected off the surface of the ocean, and uses these reflections to retrieve useful geophysical parameters of the ocean surface. GNSS-R is generating an increasing attention from the Remote Sensing community, especially in recent years, due to its numerous advantages compared to other classical remote sensing techniques. The exploitation of long-term, ubiquitous signals of opportunity freely available, the high space-time sampling capabilities and the ability of its L-band signals to penetrate well through rain all contribute to make this technique very attractive. An additional and very important strength of GNSS-R is the need for simple, low-cost/low-power GNSS receivers, that could be easily piggybacked on other satellites to form a constellation of receivers. These recognized potentials of GNSS-R have been recently led to the approval of the NASA EV-2 Cyclone Global Navigation Satellite System (CYGNSS), a spaceborne mission focused on tropical cyclone (TC) inner core process studies. GNSS-R can be used for both scatterometric applications (i.e. wind and wave monitoring) and altimetric applications (i.e. measurements of sea surface height). In particular, its ability to collect multiple GPS reflections anywhere on the globe and at any time (due to the ubiquity of GPS signals) using a large constellation of simple GNSS receivers, makes is very suitable for Real-Time (RT) and Near-Real Time (NRT) applications. These are particularly crucial for monitoring sea hazards related to ship operations and operational oceanography in general. For scatterometric purposes, GNSS-R can potentially detect high wind and waves in RT and NRT, as well as oil spills on the surface of the ocean, through its measurements of the sea surface roughness. In addition to that, GNSS-R could provide

  19. Assessing the potential hazard of chemical substances for the terrestrial environment. Development of hazard classification criteria and quantitative environmental indicators.

    PubMed

    Tarazona, J V; Fresno, A; Aycard, S; Ramos, C; Vega, M M; Carbonell, G

    2000-03-20

    Hazard assessment constitutes an essential tool in order to evaluate the potential effects of chemical substances on organisms and ecosystems. It includes as a first step, hazard identification, which must detect the potential dangers of the substance (i.e. the kind of effects that the substance may produce), and a second step to quantify each danger and to set the expected dose/response relationships. Hazard assessment plays a key role in the regulation of chemical substances, including pollution control and sustainable development. However, the aquatic environment has largely received more attention than terrestrial ecosystems. This paper presents the extrapolation of several basic concepts from the aquatic to the terrestrial compartment, and suggests possibilities for their regulatory use. Two specific proposals are discussed. The first focuses on the scientific basis of the hazard identification-classification criteria included in the EU regulations and their extrapolation to the terrestrial environment. The second focuses on the OECD programme for environmental indicators and the development of a soil pollution pressure indicator to quantify the potential hazards for the soil compartment and its associated terrestrial ecosystem related to the toxic chemicals applied deliberately (i.e. pesticides) or not (i.e. heavy metals in sludge-based fertilisers; industrial spills) to the soil.

  20. High organic containing tanks: Assessing the hazard potential

    SciTech Connect

    Hill, R.C.P.; Babad, H.

    1991-09-01

    Eight Hanford Site tanks contain organic chemicals at concentrations believed to be greater than 10 mole percent sodium acetate equivalent mixed with the oxidizing salts sodium nitrate/sodium nitrite. Also, three of the hydrogen and ferrocyanide tanks appear on the organic tank list. Concentrations of organics that may be present in some tanks could cause an exothermic reaction given a sufficient driving force, such as high temperatures. However, the difference between ignition temperatures and actual tank temperatures measured is so large that the probability of such a reaction is considered very low. The consequences of the postulated reaction are about the same as the scenarios for an explosion in a burping'' hydrogen tank. Although work on this issue is just beginning, consideration of hazards associated with heating nitrate-nitrite mixtures containing organic materials is an integral part of both the hydrogen and ferrocyanide tank efforts. High concentrations of organic compounds have been inferred (from tank transfer, flow sheet records, and limited analytical data) in eight single-shell tanks. Many organic chemicals, if present in concentrations above 10 dry weight percent (sodium acetate equivalent), have the potential to react with nitrate-nitrites constituents at temperatures above 200{degree}C (392{degree}F) in an exothermic manner. The concentrations of organic materials in the listed single-shell tanks, and their chemical identity, is not accurately known at present. A tank sampling program has been planned to provide more information on the contents of these tanks and to serve as a basis for laboratory testing and safety evaluations. 2 refs., 1 fig., 2 tabs.

  1. A comprehensive program for countermeasures against potentially hazardous objects (PHOs)

    NASA Astrophysics Data System (ADS)

    Huebner, W. F.; Johnson, L. N.; Boice, D. C.; Bradley, P.; Chocron, S.; Ghosh, A.; Giguere, P. T.; Goldstein, R.; Guzik, J. A.; Keady, J. J.; Mukherjee, J.; Patrick, W.; Plesko, C.; Walker, J. D.; Wohletz, K.

    2009-08-01

    At the hundredth anniversary of the Tunguska event in Siberia it is appropriate to discuss measures to avoid such occurrences in the future. Recent discussions about detecting, tracking, cataloguing, and characterizing near-Earth objects (NEOs) center on objects larger than about 140 m in size. However, objects smaller than 100 m are more frequent and can cause significant regional destruction of civil infrastructures and population centers. The cosmic object responsible for the Tunguska event provides a graphic example: although it is thought to have been only about 50 to 60 m in size, it devastated an area of about 2000 km2. Ongoing surveys aimed at early detection of a potentially hazardous object (PHO: asteroid or comet nucleus that approaches the Earth’s orbit within 0.05 AU) are only a first step toward applying countermeasures to prevent an impact on Earth. Because “early” may mean only a few weeks or days in the case of a Tunguska-sized object or a longperiod comet, deflecting the object by changing its orbit is beyond the means of current technology, and destruction and dispersal of its fragments may be the only reasonable solution. Highly capable countermeasures- always at the ready—are essential to defending against an object with such short warning time, and therefore short reaction time between discovery and impending impact. We present an outline for a comprehensive plan for countermeasures that includes smaller (Tunguska-sized) objects and long-period comets, focuses on short warning times, uses non-nuclear methods (e.g., hyper-velocity impactor devices and conventional explosives) whenever possible, uses nuclear munitions only when needed, and launches from the ground. The plan calls for international collaboration for action against a truly global threat.

  2. A comprehensive program for countermeasures against potentially hazardous objects (PHOs)

    SciTech Connect

    Huebner, Walter; Giguere, P T; Bradley, P; Guzik, J A; Plesko, C; Wohletz, K; Johnson, L N; Boice, D C; Chocron, S; Ghosh, A; Goldstein, R; Mukerherjee, J; Patrick, W; Walker, J D

    2008-01-01

    At the hundredth anniversary of the Tunguska event in Siberia it is appropriate to discuss measures to avoid such occurrences in the future. Recent discussions about detecting, tracking, cataloguing, and characterizing near-Earth objects (NEOs) center on objects larger than about 140 m in size. However, objects smaller than 100 m are more frequent and can cause significant regional destruction of civil infrastructures and population centers. The cosmic object responsible for the Tunguska event provides a graphic example: although it is thought to have been only about 50 to 60 m in size, it devastated an area of about 2000 km{sup 2}. Ongoing surveys aimed at early detection of a potentially hazardous object (PHO: asteroid or comet nucleus that approaches the Earth's orbit within 0.05 AU) are only a first step toward applying countermeasures to prevent an impact on Earth. Because 'early' may mean only a few weeks or days in the case of a Tunguska-sized object or a long-period comet, deflecting the object by changing its orbit is beyond the means of current technology, and destruction and dispersal of its fragments may be the only reasonable solution. Highly capable countermeasures - always at the ready - are essential to defending against an object with such short warning time, and therefore short reaction time between discovery and impending impact. We present an outline for a comprehensive plan for countermeasures that includes smaller (Tunguska-sized) objects and long-period comets, focuses on short warning times, uses non-nuclear methods (e.g., hyper-velocity impactor devices and conventional explosives) whenever possible, uses nuclear munitions only when needed, and launches from the ground. The plan calls for international collaboration for action against a truly global threat.

  3. Nanosilver: application and novel aspects of toxicology.

    PubMed

    Schluesener, Jan K; Schluesener, Hermann J

    2013-04-01

    Nanomaterials are a challenge to toxicology. The high diversity of novel materials and products will require extensive expertize for evaluation and regulatory efforts. Nanomaterials are of substantial scientific and economic potential. Here, we will focus on nanosilver, a material not only with medical applications, but a rapidly increasing use in surprisingly many products. Consequently, toxicological evaluation has to cover an increasing range of complex topics. The toxicology of nanosilver is advancing rapidly; regulatory efforts by Federal Drug Agency and European Environment Protection Agencies are substantial. Current toxicological data, ranging from in vitro studies with cell lines to rodent experiments and ecological evaluation, are numerous, and many groups are providing continuously new data. However, standard classification based on nanosize only is neglecting nanoshape, which adds another level of complexity to the analysis of biological effects. A surprising neglect in nanosilver toxicology so far is the analysis of effects of nanosilver on amyloidosis. Amyloid diseases are widespread in humans and a severe health hazard. The known potential of silver to stimulate amyloidosis in rodents will require a timely and balanced evaluation of nanosilvers.

  4. Modern tornado design of nuclear and other potentially hazardous facilities

    SciTech Connect

    Stevenson, J.D.; Zhao, Y.

    1996-01-01

    Tornado wind loads and other tornado phenomena, including tornado missiles and differential pressure effects, have not usually been considered in the design of conventional industrial, commercial, or residential facilities in the United States; however, tornado resistance has often become a design requirement for certain hazardous facilities, such as large nuclear power plants and nuclear materials and waste storage facilities, as well as large liquefied natural gas storage facilities. This article provides a review of current procedures for the design of hazardous industrial facilities to resist tornado effects. 23 refs., 19 figs., 13 tabs.

  5. Assessment of the potential for long-term toxicological effects of the Exxon Valdez oil spill on birds and mammals

    SciTech Connect

    Hartung, R.

    1995-12-31

    This paper assesses the potential for direct long-term toxicological effects of exposures to oils in birds and mammals by tracing exposures and effects form the initial cute phases through the sub-chronic to the eventual long-term exposures. The immediate effects of oil spills are physical, the oil acting on the plumage of birds or the fur of mammals. This causes a loss of entrained air and a concomitant reduction in buoyancy and thermal insulation. Animals that escape the immediate impacts may be isolated from their food supply and often ingest large amounts of oil while attempting to clean themselves. At the comparatively high dose levels involved, these exposures can result in toxicologically significant responses in many organ systems. In the course of an oil pollution incident, the amounts of biologically available oils decrease steadily, and simultaneously the composition of the oils shifts towards those components that have low volatility, and that resist photo- and bio-degradation. As this occurs, the primary pathways of exposure change from direct intakes to indirect routes involving the food supply. Although laboratory studies often report finding some adverse effects, the dose rates employed in many of these studies are extremely high when compared with those that are potentially available to animals in the wild, and very few actually use weathered oils. An assessment of the toxicological literature and of the available empirical data on the Exxon Valdez oil spill leads to the conclusion that long-term sub-lethal toxic effects of crude oils on wildlife in such marine spills appear to be very unlikely. 111 refs., 4 figs., 1 tab.

  6. 14 CFR 135.67 - Reporting potentially hazardous meteorological conditions and irregularities of ground facilities...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Reporting potentially hazardous meteorological conditions and irregularities of ground facilities or navigation aids. 135.67 Section 135.67... navigation aids. Whenever a pilot encounters a potentially hazardous meteorological condition or...

  7. 14 CFR 135.67 - Reporting potentially hazardous meteorological conditions and irregularities of ground facilities...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Reporting potentially hazardous meteorological conditions and irregularities of ground facilities or navigation aids. 135.67 Section 135.67... navigation aids. Whenever a pilot encounters a potentially hazardous meteorological condition or...

  8. 14 CFR 135.67 - Reporting potentially hazardous meteorological conditions and irregularities of ground facilities...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Reporting potentially hazardous meteorological conditions and irregularities of ground facilities or navigation aids. 135.67 Section 135.67... navigation aids. Whenever a pilot encounters a potentially hazardous meteorological condition or...

  9. 14 CFR 135.67 - Reporting potentially hazardous meteorological conditions and irregularities of ground facilities...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Reporting potentially hazardous meteorological conditions and irregularities of ground facilities or navigation aids. 135.67 Section 135.67... navigation aids. Whenever a pilot encounters a potentially hazardous meteorological condition or...

  10. 14 CFR 135.67 - Reporting potentially hazardous meteorological conditions and irregularities of ground facilities...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Reporting potentially hazardous meteorological conditions and irregularities of ground facilities or navigation aids. 135.67 Section 135.67... navigation aids. Whenever a pilot encounters a potentially hazardous meteorological condition or...

  11. Butt rot defect and potential hazard in lodgepole pine on selected California recreational areas

    Treesearch

    Lee A. Paine

    1966-01-01

    Within the area sampled, potentially hazardous lodgepole pine were common on recreational sites. The incidence of decayed and mechanically weak trees was correlated with fire damage. Two-thirds of fire-scarred trees were decayed; one-third were rated potentially hazardous. Fire scars occurred roughly in proportion to level of plot recreational use.

  12. 7 CFR Appendix A to Subpart E of... - Hazard Potential Classification for Civil Works Projects

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 11 2014-01-01 2014-01-01 false Hazard Potential Classification for Civil Works... (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC ENGINEERING, ARCHITECTURAL SERVICES... Subpart E of Part 1724—Hazard Potential Classification for Civil Works Projects The source for...

  13. Modeling hazardous fire potential within a completed fuel treatment network in the northern Sierra Nevada

    Treesearch

    Brandon M. Collins; Heather A. Kramer; Kurt Menning; Colin Dillingham; David Saah; Peter A. Stine; Scott L. Stephens

    2013-01-01

    We built on previous work by performing a more in-depth examination of a completed landscape fuel treatment network. Our specific objectives were: (1) model hazardous fire potential with and without the treatment network, (2) project hazardous fire potential over several decades to assess fuel treatment network longevity, and (3) assess fuel treatment effectiveness and...

  14. An algorithm for evaluating potential tissue drug distribution in toxicology studies from readily available pharmacokinetic parameters.

    PubMed

    Poulin, Patrick; Dambach, Donna M; Hartley, Dylan H; Ford, Kevin; Theil, Frank-Peter; Harstad, Eric; Halladay, Jason; Choo, Edna; Boggs, Jason; Liederer, Bianca M; Dean, Brian; Diaz, Dolores

    2013-10-01

    Having an understanding of drug tissue accumulation can be informative in the assessment of target organ toxicities; however, obtaining tissue drug levels from toxicology studies by bioanalytical methods is labor-intensive and infrequently performed. Additionally, there are no described methods for predicting tissue drug distribution for the experimental conditions in toxicology studies, which typically include non-steady-state conditions and very high exposures that may saturate several processes. The aim was the development of an algorithm to provide semiquantitative and quantitative estimates of tissue-to-plasma concentration ratios (Kp ) for several tissues from readily available parameters of pharmacokinetics (PK) such as volume of distribution (Vd ) and clearance of each drug, without performing tissue measurement in vivo. The computational approach is specific for the oral route of administration and non-steady-state conditions and was applied for a dataset of 29 Genentech small molecules such as neutral compounds as well as weak and strong organic bases. The maximum success rate in predicting Kp values within 2.5-fold error of observed Kp values was 82% at low doses (<100 mg/kg) in preclinical species. Prediction accuracy was relatively lower with saturation at high doses (≥100 mg/kg); however, an approach to perform low-to-high dose extrapolations of Kp values was presented and applied successfully in most cases. An approach for the interspecies scaling was also applied successfully. Finally, the proposed algorithm was used in a case study and successfully predicted differential tissue distribution of two small-molecule MET kinase inhibitors, which had different toxicity profiles in mice. This newly developed algorithm can be used to predict the partition coefficients Kp for small molecules in toxicology studies, which can be leveraged to optimize the PK drivers of tissue distribution in an attempt to decrease drug tissue level, and improve safety

  15. TREATABILITY POTENTIAL FOR EPA LISTED HAZARDOUS WASTES IN SOIL

    EPA Science Inventory

    This study developed comprehensive screening data on the treatability in soil of: (a) specific listed hazardous organic chemicals, and (b) waste sludge from explosives production (K044) and related chemicals. Laboratory experiments were conducted using two soil types, an acidic s...

  16. Toxicological Risks During Human Space Exploration

    NASA Technical Reports Server (NTRS)

    James, John T.; Limero, T. F.; Lam, C. W.; Billica, Roger (Technical Monitor)

    2000-01-01

    The goal of toxicological risk assessment of human space flight is to identify and quantify significant risks to astronaut health from air pollution inside the vehicle or habitat, and to develop a strategy for control of those risks. The approach to completing a toxicological risk assessment involves data and experience on the frequency and severity of toxicological incidents that have occurred during space flight. Control of these incidents depends on being able to understand their cause from in-flight and ground-based analysis of air samples, crew reports of air quality, and known failures in containment of toxic chemicals. Toxicological risk assessment in exploration missions must be based on an evaluation of the unique toxic hazards presented by the habitat location. For example, lunar and Martian dust must be toxicologically evaluated to determine the appropriate control measures for exploration missions. Experience with near-earth flights has shown that the toxic products from fires present the highest risk to crew health from air pollution. Systems and payload leaks also present a significant hazard. The health risk from toxicity associated with materials offgassing or accumulation of human metabolites is generally well controlled. Early tests of lunar and Martian dust simulants have shown that each posses the potential to cause fibrosis in the lung in a murine model. Toxicological risks from air pollutants in space habitats originate from many sources. A number of risks have been identified through near-earth operations; however, the evaluation of additional new risks present during exploration missions will be a challenge.

  17. Characterization of the Potential Hazards Associated with Potential RCRA Treatment Noncompliances

    SciTech Connect

    Clark, David Lewis

    2015-08-20

    The purpose of this document is to provide a hazard evaluation of the noncompliances and whether any new actions are required to mitigate potential risk to the worker or the public. In short, we have reviewed the noncompliances and have concluded that the possibility of exothermic reactions leading to radioactive release is not credible, and in one case, inconceivable, stemming from the fact that the majority fraction of the waste is compatible with organic absorbents and neutralizers. It is not expected that the noncompliances would generate or produce uncontrolled flammable fumes, gases, extreme heat, pressure, fire, explosions, or violent reactions.

  18. Potential of MALDI imaging for the toxicological evaluation of environmental pollutants.

    PubMed

    Lagarrigue, Mélanie; Caprioli, Richard M; Pineau, Charles

    2016-07-20

    Risk assessment related to the exposure of humans to chemicals released into the environment is a major concern of our modern societies. In this context, toxicology plays a crucial role to characterize the effects of this exposure on health and identify the targets of these molecules. MALDI imaging mass spectrometry (IMS) is an enabling technology for biodistribution studies of chemicals. Although the majority of published studies are presented in a pharmacological context, the concepts discussed in this review can be applied to the toxicological evaluation of chemicals released into the environment. The major asset of IMS is the simultaneous localization and identification of a parent molecule and its metabolites without labeling and without any prior knowledge. Quantification methods developed in IMS are presented with application to an environmental pollutant. IMS is effective in the localization of chemicals and endogenous species. This opens unique perspectives for the discovery of molecular alterations in metabolites and protein biomarkers that could help for a better understanding of toxicity mechanisms. Distribution studies of agrochemicals in plants by IMS can contribute to a better understanding of their mode of action and to a more effective use of these chemicals, avoiding the current concern of environmental damage.

  19. Advancing alternatives analysis: The role of predictive toxicology in selecting safer chemical products and processes.

    PubMed

    Malloy, Timothy; Zaunbrecher, Virginia; Beryt, Elizabeth; Judson, Richard; Tice, Raymond; Allard, Patrick; Blake, Ann; Cote, Ila; Godwin, Hilary; Heine, Lauren; Kerzic, Patrick; Kostal, Jakub; Marchant, Gary; McPartland, Jennifer; Moran, Kelly; Nel, Andre; Ogunseitan, Oladele; Rossi, Mark; Thayer, Kristina; Tickner, Joel; Whittaker, Margaret; Zarker, Ken

    2017-09-01

    Alternatives analysis (AA) is a method used in regulation and product design to identify, assess, and evaluate the safety and viability of potential substitutes for hazardous chemicals. It requires toxicological data for the existing chemical and potential alternatives. Predictive toxicology uses in silico and in vitro approaches, computational models, and other tools to expedite toxicological data generation in a more cost-effective manner than traditional approaches. The present article briefly reviews the challenges associated with using predictive toxicology in regulatory AA, then presents 4 recommendations for its advancement. It recommends using case studies to advance the integration of predictive toxicology into AA, adopting a stepwise process to employing predictive toxicology in AA beginning with prioritization of chemicals of concern, leveraging existing resources to advance the integration of predictive toxicology into the practice of AA, and supporting transdisciplinary efforts. The further incorporation of predictive toxicology into AA would advance the ability of companies and regulators to select alternatives to harmful ingredients, and potentially increase the use of predictive toxicology in regulation more broadly. Integr Environ Assess Manag 2017;13:915-925. © 2017 SETAC. © 2017 SETAC.

  20. Physicochemical and toxicological profiling of ash from the 2010 and 2011 eruptions of Eyjafjallajökull and Grímsvötn volcanoes, Iceland using a rapid respiratory hazard assessment protocol.

    PubMed

    Horwell, C J; Baxter, P J; Hillman, S E; Calkins, J A; Damby, D E; Delmelle, P; Donaldson, K; Dunster, C; Fubini, B; Kelly, F J; Le Blond, J S; Livi, K J T; Murphy, F; Nattrass, C; Sweeney, S; Tetley, T D; Thordarson, T; Tomatis, M

    2013-11-01

    The six week eruption of Eyjafjallajökull volcano in 2010 produced heavy ash fall in a sparsely populated area of southern and south eastern Iceland and disrupted European commercial flights for at least 6 days. We adopted a protocol for the rapid analysis of volcanic ash particles, for the purpose of informing respiratory health risk assessments. Ash collected from deposits underwent a multi-laboratory physicochemical and toxicological investigation of their mineralogical parameters associated with bio-reactivity, and selected in vitro toxicology assays related to pulmonary inflammatory responses. Ash from the eruption of Grímsvötn, Iceland, in 2011 was also studied. The results were benchmarked against ash from Soufrière Hills volcano, Montserrat, which has been extensively studied since the onset of eruptive activity in 1995. For Eyjafjallajökull, the grain size distributions were variable: 2-13 vol% of the bulk samples were <4 µm, with the most explosive phases of the eruption generating abundant respirable particulate matter. In contrast, the Grímsvötn ash was almost uniformly coarse (<3.5 vol%<4 µm material). Surface area ranged from 0.3 to 7.7 m2 g(-1) for Eyjafjallajökull but was very low for Grímsvötn (<0.6 m2 g(-1)). There were few fibre-like particles (which were unrelated to asbestos) and the crystalline silica content was negligible in both eruptions, whereas Soufrière Hills ash was cristobalite-rich with a known potential to cause silicosis. All samples displayed a low ability to deplete lung antioxidant defences, showed little haemolysis and low acute cytotoxicity in human alveolar type-1 like epithelial cells (TT1). However, cell-free tests showed substantial hydroxyl radical generation in the presence of hydrogen peroxide for Grímsvötn samples, as expected for basaltic, Fe-rich ash. Cellular mediators MCP-1, IL-6, and IL-8 showed chronic pro-inflammatory responses in Eyjafjallajökull, Grímsvötn and Soufrière Hills samples

  1. [Contemporary animal nutrition and its potential hazards to human health (author's transl)].

    PubMed

    Somogyi, A; Malick, L E; Langenbach, R; Sallach, K

    1976-01-01

    .g., inducers or inhibitors of microsomal enzymes) means can result in a profound change of various biological actions of chemicals (e.g., cytotoxicity, carcinogenicity, mutagenicity). To ascertain that potential toxicological hazards to human health by animal drugs and feed additives will be recognized during the phase of testing, appropriate test animals have to be selected with great care. It is indispensible that the metabolic break-down of the investigational substance proceeds via similar pathways in both test animals and the target species. This will assure that the same metabolites which, in the form of residues in food, man might be exposed to will have ample opportunity to exert their possible adverse effects to the experimental animals during a life-long feeding of the test substance. Therefore, it can, with a reasonable certainty, be assumed that, in experiments performed under such precautionary measures, toxico-pharmacological properties relevant to human safety evaluation will not remain undetected.

  2. [Hygienic forecasting and toxicologic evaluation of potential danger caused by new sulphenamide vulcanization accelerators].

    PubMed

    Latyshevskaia, N I; Novikova, O N; Iudina, E V; Skakovskaia, M A

    2005-01-01

    The article covers forecasting work conditions in oncoming production of sulphenamides T and DC--vulcanization accelerators, specifies leading occupational hazards, justifies values of MAC for sulphenamide T and approximate safe levels of action for sulphenamide DC in air of workplace.

  3. Space Toxicology

    NASA Technical Reports Server (NTRS)

    James, John T.

    2011-01-01

    Safe breathing air for space faring crews is essential whether they are inside an Extravehicular Mobility Suit (EMU), a small capsule such as Soyuz, or the expansive International Space Station (ISS). Sources of air pollution can include entry of propellants, excess offgassing from polymeric materials, leakage of systems compounds, escape of payload compounds, over-use of utility compounds, microbial metabolism, and human metabolism. The toxicological risk posed by a compound is comprised of the probability of escaping to cause air pollution and the magnitude of adverse effects on human health if escape occurs. The risk from highly toxic compounds is controlled by requiring multiple levels of containment to greatly reduce the probability of escape; whereas compounds that are virtually non-toxic may require little or no containment. The potential for toxicity is determined by the inherent toxicity of the compound and the amount that could potentially escape into the breathing air.

  4. Oral-toxicology

    PubMed Central

    Gowda, B. K. Charan; Sundharam, B. Sivapatha; Mahadesh, Jyothi; Mukund

    2014-01-01

    Forensic toxicology deals with the investigation of toxic substances, poisonous products or with the environmental chemicals. This field of science helps to identify poison substance and hazardous chemicals. Forensic toxicology deals with the way that substances are absorbed, distributed or eliminated in the body – the metabolism of substances. This paper reviews the manifestations that each poisonous substance presents concentrating toward the commonly used poisonous substance especially in India. It also explains the Indian Penal Code, which is main criminal code intended to cover all substantive aspects of criminal law regarding poison. PMID:24696586

  5. Toxicological benchmarks for potential contaminants of concern for effects on soil and litter invertebrates and heterotrophic process

    SciTech Connect

    Will, M.E.; Suter, G.W. II

    1995-09-01

    An important step in ecological risk assessments is screening the chemicals occur-ring on a site for contaminants of potential concern. Screening may be accomplished by comparing reported ambient concentrations to a set of toxicological benchmarks. Multiple endpoints for assessing risks posed by soil-borne contaminants to organisms directly impacted by them have been established. This report presents benchmarks for soil invertebrates and microbial processes and addresses only chemicals found at United States Department of Energy (DOE) sites. No benchmarks for pesticides are presented. After discussing methods, this report presents the results of the literature review and benchmark derivation for toxicity to earthworms (Sect. 3), heterotrophic microbes and their processes (Sect. 4), and other invertebrates (Sect. 5). The final sections compare the benchmarks to other criteria and background and draw conclusions concerning the utility of the benchmarks.

  6. Facilities Potentially Subject to the Secondary Aluminum National Emission Standards for Hazardous Air Pollutants (NESHAP)

    EPA Pesticide Factsheets

    This document contains a September 2001 list of sources potentially subject to the secondary aluminum production national emission standards for hazardous air pollutants (NESHAP). This list does not include auto salvage i.e. sweat furnaces.

  7. Chemical and toxicological characterization of residential oil burner emissions: II. Mutagenic, tumorigenic, and potential teratogenic activity.

    PubMed Central

    Braun, A G; Busby, W F; Liber, H L; Thilly, W G

    1987-01-01

    Extracts of effluents from a modern residential oil burner have been evaluated in several toxicological assay systems. Bacterial mutagens were detected in extracts from both the particulate and vapor phase emissions. Effluents from continuous operation were an order of magnitude less mutagenic than those from cyclic (5 min on, 10 min off) operations. No difference in the yield of bacterial mutagens per gram of fuel burned was found between cyclic operation under low and moderate sooting conditions. On the basis of elution behavior from alumina it appeared that the bacterial mutagens collected from high sooting effluents were more polar than those from low sooting effluent. An extract that was mutagenic in bacteria did not induce a significant increase in mutation frequency to human lymphoblasts. No evidence of tumorigenicity was observed in a limited number of newborn mice after IP injection of effluent extract when compared to historical control data. Putative nonmutagenic teratogens were detected in effluent using an attachment inhibition assay. The level of these agents was reduced in effluents from continuous oil burner operation. PMID:3665866

  8. An evaluation of the toxicological aspects and potential doses from the inhalation of coal combustion products.

    PubMed

    Liberda, Eric N; Chen, Lung Chi

    2013-06-01

    This paper reviews toxicological literature pertaining to coal combustion products (CCPs) inhalation and presents case studies on the inhalation of CCPs from the Kingston Fossil Plant area and from the Colbert Fossil Plant CCP landfill site. While most research regarding coal plant emissions focuses on fly ash, this article takes a holistic approach to examining not only emitted particulate matter such as fly ash, but also the theoretical calculated doses of landfilled CCPs. Furthermore, these doses are compared to in vitro and in vivo studies in order to highlight differences between laboratory-based studies and to emphasize the difficulty in extrapolating effects from inhalation exposures. In both case studies, fugitive emissions from the Kingston ash spill or the Colbert CCP-handling operations did not exceed any national ambient air quality standards or reference concentrations for individual components. Adverse effects such as mild pulmonary inflammation noted in the reviewed literature were in response to doses much higher than would be likely to occur in humans exposed to landfilled CCPs. We conclude that the doses for fugitive emissions calculated herein do not appear to be high enough to elicit a measurable adverse response in humans.

  9. Potential health effects of gasoline and its constituents: A review of current literature (1990-1997) on toxicological data.

    PubMed Central

    Caprino, L; Togna, G I

    1998-01-01

    We reviewed toxicological studies, both experimental and epidemiological, that appeared in international literature in the period 1990-1997 and included both leaded and unleaded gasolines as well as their components and additives. The aim of this overview was to select, arrange, and present references of scientific papers published during the period under consideration and to summarize the data in order to give a comprehensive picture of the results of toxicological studies performed in laboratory animals (including carcinogenic, teratogenic, or embryotoxic activity), mutagenicity and genotoxic aspects in mammalian and bacterial systems, and epidemiological results obtained in humans in relation to gasoline exposure. This paper draws attention to the inherent difficulties in assessing with precision any potential adverse effects on health, that is, the risk of possible damage to man and his environment from gasoline. The difficulty of risk assessment still exists despite the fact that the studies examined are definitely more technically valid than those of earlier years. The uncertainty in overall risk determination from gasoline exposure also derives from the conflicting results of different studies, from the lack of a correct scientific approach in some studies, from the variable characteristics of the different gasoline mixtures, and from the difficulties of correctly handling potentially confounding variables related to lifestyle (e.g., cigarette smoking, drug use) or to preexisting pathological conditions. In this respect, this paper highlights the need for accurately assessing the conclusive explanations reported in scientific papers so as to avoid the spread of inaccurate or misleading information on gasoline toxicity in nonscientific papers and in mass-media messages. PMID:9452413

  10. Metabolomics in Toxicology and Preclinical Research

    PubMed Central

    Ramirez, Tzutzuy; Daneshian, Mardas; Kamp, Hennicke; Bois, Frederic Y.; Clench, Malcolm R.; Coen, Muireann; Donley, Beth; Fischer, Steven M.; Ekman, Drew R.; Fabian, Eric; Guillou, Claude; Heuer, Joachim; Hogberg, Helena T.; Jungnickel, Harald; Keun, Hector C.; Krennrich, Gerhard; Krupp, Eckart; Luch, Andreas; Noor, Fozia; Peter, Erik; Riefke, Bjoern; Seymour, Mark; Skinner, Nigel; Smirnova, Lena; Verheij, Elwin; Wagner, Silvia; Hartung, Thomas; van Ravenzwaay, Bennard; Leist, Marcel

    2013-01-01

    Summary Metabolomics, the comprehensive analysis of metabolites in a biological system, provides detailed information about the biochemical/physiological status of a biological system, and about the changes caused by chemicals. Metabolomics analysis is used in many fields, ranging from the analysis of the physiological status of genetically modified organisms in safety science to the evaluation of human health conditions. In toxicology, metabolomics is the -omics discipline that is most closely related to classical knowledge of disturbed biochemical pathways. It allows rapid identification of the potential targets of a hazardous compound. It can give information on target organs and often can help to improve our understanding regarding the mode-of-action of a given compound. Such insights aid the discovery of biomarkers that either indicate pathophysiological conditions or help the monitoring of the efficacy of drug therapies. The first toxicological applications of metabolomics were for mechanistic research, but different ways to use the technology in a regulatory context are being explored. Ideally, further progress in that direction will position the metabolomics approach to address the challenges of toxicology of the 21st century. To address these issues, scientists from academia, industry, and regulatory bodies came together in a workshop to discuss the current status of applied metabolomics and its potential in the safety assessment of compounds. We report here on the conclusions of three working groups addressing questions regarding 1) metabolomics for in vitro studies 2) the appropriate use of metabolomics in systems toxicology, and 3) use of metabolomics in a regulatory context. PMID:23665807

  11. Potential Explosion Hazard of Carbonaceous Nanoparticles: Screening of Allotropes

    PubMed Central

    Turkevich, Leonid A.; Fernback, Joseph; Dastidar, Ashok G.; Osterberg, Paul

    2016-01-01

    There is a concern that engineered carbon nanoparticles, when manufactured on an industrial scale, will pose an explosion hazard. Explosion testing has been performed on 20 codes of carbonaceous powders. These include several different codes of SWCNTs (single-walled carbon nanotubes), MWCNTs (multi-walled carbon nanotubes) and CNFs (carbon nanofibers), graphene, diamond, fullerene, as well as several different control carbon blacks and graphites. Explosion screening was performed in a 20 L explosion chamber (ASTM E1226 protocol), at a concentration of 500 g/m3, using a 5 kJ ignition source. Time traces of overpressure were recorded. Samples typically exhibited overpressures of 5–7 bar, and deflagration index KSt = V1/3 (dP/dt)max ~ 10 – 80 bar-m/s, which places these materials in European Dust Explosion Class St-1. There is minimal variation between these different materials. The explosive characteristics of these carbonaceous powders are uncorrelated with primary particle size (BET specific surface area). PMID:27468178

  12. Potential Explosion Hazard of Carbonaceous Nanoparticles: Screening of Allotropes.

    PubMed

    Turkevich, Leonid A; Fernback, Joseph; Dastidar, Ashok G; Osterberg, Paul

    2016-05-01

    There is a concern that engineered carbon nanoparticles, when manufactured on an industrial scale, will pose an explosion hazard. Explosion testing has been performed on 20 codes of carbonaceous powders. These include several different codes of SWCNTs (single-walled carbon nanotubes), MWCNTs (multi-walled carbon nanotubes) and CNFs (carbon nanofibers), graphene, diamond, fullerene, as well as several different control carbon blacks and graphites. Explosion screening was performed in a 20 L explosion chamber (ASTM E1226 protocol), at a concentration of 500 g/m(3), using a 5 kJ ignition source. Time traces of overpressure were recorded. Samples typically exhibited overpressures of 5-7 bar, and deflagration index KSt = V(1/3) (dP/dt)max ~ 10 - 80 bar-m/s, which places these materials in European Dust Explosion Class St-1. There is minimal variation between these different materials. The explosive characteristics of these carbonaceous powders are uncorrelated with primary particle size (BET specific surface area).

  13. Enhancement of nitrite on heme-induced oxidative reactions: A potential toxicological implication.

    PubMed

    Lu, Naihao; Chen, Wei; Zhu, Jingjie; Peng, Yi-Yuan

    2012-02-01

    Evidence to support the role of heme as major inducers of oxidative damage is increasingly present. Nitrite (NO(2)(-)) is one of the major end products of NO metabolism. Although the biological significance of heme/NO(2)(-)-mediated protein tyrosine nitration is a subject of great interest, the important roles of NO(2)(-) on heme-dependent redox reaction have been greatly underestimated. In this study, we investigated the influence of NO(2)(-) on heme -dependent oxidative reactions. It was found that NO(2)(-) had the capacity to act as a reducing agent to remove high oxidation states of heme iron. In the reduction of ferryl heme to ferric heme, NO(2)(-) was oxidized to a nitrating agent NO(2), and subsequently, tyrosine residues in bovine serum albumin (BSA) were nitrated. However, the presence of NO(2)(-) surprisingly exerted pro-oxidant effect on heme-H(2)O(2)-induced formation of BSA carbonyls at lower concentrations and enhanced the loss of HepG2 cell viability dose-dependently, which was probably due to the ability of this inorganic compound to efficiently enhance the peroxidase activity and oxidative degradation of heme. These data provide novel evidence that the dietary intake and experimental use of NO(2)(-) in vivo and in vitro would possess the pro-oxidant activity through interfering in heme-dependent oxidative reactions. Besides the classic role in protein tyrosine nitration, the deleterious effects on heme redox reactions may provide new insights into the toxicological implications of NO(2)(-) with cellular heme proteins. Copyright © 2011 Elsevier Ltd. All rights reserved.

  14. Volcanic ash: a potential hazard for aviation in Southeast Asia

    NASA Astrophysics Data System (ADS)

    Whelley, P. L.; Newhall, C. G.

    2012-12-01

    There are more than 400 volcanoes in Southeast Asia. Ash from eruptions of Volcanic Explosivity Index 3 (VEI 3) and larger pose local hazards and eruptions of VEI 4 or greater could disrupt trade, travel, and daily life in large parts of the region. To better manage and understand the risk volcanic ash poses to Southeast Asia, this study quantifies the long-term probability of a large eruption sending ash into the Singapore Flight Information Region (FIR), which is a 1,700 km long, quasi-rectangular zone from the Strait of Malacca to the South China Sea. Southeast Asian volcanoes are classified into 6 groups, using satellite data, by their morphology, and where known, their eruptive history. 'Laguna' type are fields of maars, cinder cones and spatter cones, named for the Laguna Volcanic Field, Philippines (13.204, 123.525). 'Kembar' type are broad, gently sloping shield volcanoes with extensive lava flows (Kembar Volcano, Indonesia: 3.850, 097.664). 'Mayon' type volcanoes are open-vent, frequently active, steep sided stratocones with small summit craters, spatter ramparts, small pyroclastic fans (typically < 3 km but up to 5 km) and lava flows (Mayon Volcano, Philippines: 13.257, 123.685). 'Kelut' type are semi-plugged composite cones with dome complexes, pyroclastic fans, and/or debris avalanche deposits (Kelut Volcano, Indonesia: -7.933, 112.308). 'Pinatubo' type are large plugged stratovolcanoes with extensive (tens of km) pyroclastic fans and large summit craters or calderas up to 5 km in diameter (Pinatubo Volcano, Philippines: 15.133, 120.350). 'Toba' type are calderas with long axes > 5 km and surrounded by ignimbrite sheets (Toba Caldera, Indonesia: 02.583, 098.833). In addition silicic dome complexes that might eventually produce large caldera-forming eruptions are also classified as Toba type. The eruptive histories of most volcanoes in Southeast Asia are poorly constrained. Assuming that volcanoes with similar morphologies have had similar eruption

  15. Linking vegetation patterns to potential smoke production and fire hazard

    Treesearch

    Roger D. Ottmar; Ernesto Alvarado

    2004-01-01

    During the past 80 years, various disturbances (such as wildfire and wind events) and management actions (including fire exclusion, logging, and domestic livestock grazing) have significantly modified the composition and structure of forests and ranges across the western United States. The resulting fuel loadings directly influence potential smoke production from...

  16. Group Calls for More Focus on Potentially Hazardous Asteroids

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2014-12-01

    A group of astronauts, scientists, business leaders, and artists are calling for a dramatic increase in detecting and monitoring asteroids that could potentially strike the Earth catastrophically. They have announced that 30 June 2015 will be a global asteroid awareness day.

  17. Potential hazards due to food additives in oral hygiene products.

    PubMed

    Tuncer Budanur, Damla; Yas, Murat Cengizhan; Sepet, Elif

    2016-01-01

    Food additives used to preserve flavor or to enhance the taste and appearance of foods are also available in oral hygiene products. The aim of this review is to provide information concerning food additives in oral hygiene products and their adverse effects. A great many of food additives in oral hygiene products are potential allergens and they may lead to allergic reactions such as urticaria, contact dermatitis, rhinitis, and angioedema. Dental practitioners, as well as health care providers, must be aware of the possibility of allergic reactions due to food additives in oral hygiene products. Proper dosage levels, delivery vehicles, frequency, potential benefits, and adverse effects of oral health products should be explained completely to the patients. There is a necessity to raise the awareness among dental professionals on this subject and to develop a data gathering system for possible adverse reactions.

  18. Ceiling (attic) dust: a "museum" of contamination and potential hazard.

    PubMed

    Davis, Jeffrey J; Gulson, Brian L

    2005-10-01

    . Significant correlations (P0.03) were observed between most of the metals As-Cd-Cu-Pb-Sb-Zn, especially from the industrial settings. Pathways of dust exposure in this study are classified as being passive or active based upon the probable route of dust infiltration. Ceiling dusts pose a probable health hazard if the dust is disturbed and allowed to plume within the living areas of a dwelling, thereby exposing the occupants, especially children, to elevated levels of metals and fine particulates. Modeling shows that exposure to the elevated levels of Pb in dust could give rise to blood lead concentrations exceeding current guidelines for the industrial and semi-industrial areas.

  19. NanoRiskCat: a conceptual tool for categorization and communication of exposure potentials and hazards of nanomaterials in consumer products

    NASA Astrophysics Data System (ADS)

    Hansen, Steffen Foss; Jensen, Keld Alstrup; Baun, Anders

    2014-01-01

    The literature on nano(eco)toxicology is growing rapidly and has become increasingly difficult to interpret. We have developed a systematic tool called NanoRiskCat that can support companies and regulators in their first-tier assessment and communication on what they know about the hazard and exposure potential of consumer products containing engineered nanomaterials. The final outcome of NanoRiskCat is communicated in the form of a short-title describing the intended use and five colored dots. The first three dots refer to the qualitative exposure potential for professional end-users, consumers and the environment, whereas the last two refers to the hazard potential for humans and the environment. Each dot can be assigned one of four different colors, i.e. red, yellow, green, and gray indicating high, medium, low, and unknown, respectively. In this paper, we first introduce the criteria used to evaluate the exposure potential and the human and environmental hazards of specific uses of the nanoproduct. We then apply NanoRiskCat to eight different nanoproducts. The human and environmental exposure potential was found to be high (i.e., red) for many of the products due to direct application on skin and subsequent environmental release. In the NanoRiskCat evaluation, many of the nanomaterials achieve a red human and environmental hazard profile as there is compelling in vivo evidence to associate them with irreversible effects, e.g., carcinogenicity, respiratory, and cardiovascular effects, etc., in laboratory animals. A significant strength of NanoRiskCat is that it can be used even in cases where lack of data is prominent.

  20. Data Mining in the U.S. National Toxicology Program (NTP) Database Reveals a Potential Bias Regarding Liver Tumors in Rodents Irrespective of the Test Agent

    PubMed Central

    Ring, Matthias; Eskofier, Bjoern M.

    2015-01-01

    Long-term studies in rodents are the benchmark method to assess carcinogenicity of single substances, mixtures, and multi-compounds. In such a study, mice and rats are exposed to a test agent at different dose levels for a period of two years and the incidence of neoplastic lesions is observed. However, this two-year study is also expensive, time-consuming, and burdensome to the experimental animals. Consequently, various alternatives have been proposed in the literature to assess carcinogenicity on basis of short-term studies. In this paper, we investigated if effects on the rodents’ liver weight in short-term studies can be exploited to predict the incidence of liver tumors in long-term studies. A set of 138 paired short- and long-term studies was compiled from the database of the U.S. National Toxicology Program (NTP), more precisely, from (long-term) two-year carcinogenicity studies and their preceding (short-term) dose finding studies. In this set, data mining methods revealed patterns that can predict the incidence of liver tumors with accuracies of over 80%. However, the results simultaneously indicated a potential bias regarding liver tumors in two-year NTP studies. The incidence of liver tumors does not only depend on the test agent but also on other confounding factors in the study design, e.g., species, sex, type of substance. We recommend considering this bias if the hazard or risk of a test agent is assessed on basis of a NTP carcinogenicity study. PMID:25658102

  1. Data mining in the U.S. National Toxicology Program (NTP) database reveals a potential bias regarding liver tumors in rodents irrespective of the test agent.

    PubMed

    Ring, Matthias; Eskofier, Bjoern M

    2015-01-01

    Long-term studies in rodents are the benchmark method to assess carcinogenicity of single substances, mixtures, and multi-compounds. In such a study, mice and rats are exposed to a test agent at different dose levels for a period of two years and the incidence of neoplastic lesions is observed. However, this two-year study is also expensive, time-consuming, and burdensome to the experimental animals. Consequently, various alternatives have been proposed in the literature to assess carcinogenicity on basis of short-term studies. In this paper, we investigated if effects on the rodents' liver weight in short-term studies can be exploited to predict the incidence of liver tumors in long-term studies. A set of 138 paired short- and long-term studies was compiled from the database of the U.S. National Toxicology Program (NTP), more precisely, from (long-term) two-year carcinogenicity studies and their preceding (short-term) dose finding studies. In this set, data mining methods revealed patterns that can predict the incidence of liver tumors with accuracies of over 80%. However, the results simultaneously indicated a potential bias regarding liver tumors in two-year NTP studies. The incidence of liver tumors does not only depend on the test agent but also on other confounding factors in the study design, e.g., species, sex, type of substance. We recommend considering this bias if the hazard or risk of a test agent is assessed on basis of a NTP carcinogenicity study.

  2. Potential chlordane mobilization and transport at a hazardous waste site

    SciTech Connect

    Johnson-Logan, L.R.; Klaine, S.J. )

    1990-01-01

    Elevated levels of the insecticide, chlordane, have been found in soils and sediments in the vicinity of the superfund site, North Hollywood Dump in Memphis, Tennessee. The site is a closed municipal/industrial landfill located on the alluvial plain and abandoned channels of the Wolf River. The general direction of the ground water flow is radically away from the dump but towards the river. In the following study, batch solubility and sorption experiments in combination with leaching studies using DOC were used to determine the potential for chlordane mobilization and transport at the site.

  3. Alcohol hand gel--a potential fire hazard.

    PubMed

    O'Leary, Fionnuala M; Price, Gareth J

    2011-01-01

    Alcohol hand gel and wipes are the common method of disinfecting the hands of healthcare workers and working surfaces in clinical settings. We present a case of a 40-year-old health care support worker who was referred acutely to our burns unit following flame burns in association with alcohol gel use. Fortunately she was able to extinguish the flames without sustaining a significant thermal injury however this case highlights the potential danger associated with alcohol gel use, especially with smokers. With the ever increasing use of alcohol hand gel, not only in healthcare settings but also in the general population there needs to be clearer warnings regarding the potential for ignition after use. Alcohol hand gel and wipes are the common method of disinfecting the hands of healthcare workers and working surfaces in clinical settings. Most trusts have strict policies regarding mandatory sanitisation of hands before and after patient contact. This is most easily achieved by the use of alcohol gel due to its ease of use and quick drying properties. As a result alcohol hand disinfectant is available is a variety of formats including foam, gel and wipes. It is also now widely available for use to the general public. Crown Copyright © 2010. Published by Elsevier Ltd. All rights reserved.

  4. Nano-technology and nano-toxicology.

    PubMed

    Maynard, Robert L

    2012-01-01

    Rapid developments in nano-technology are likely to confer significant benefits on mankind. But, as with perhaps all new technologies, these benefits are likely to be accompanied by risks, perhaps by new risks. Nano-toxicology is developing in parallel with nano-technology and seeks to define the hazards and risks associated with nano-materials: only when risks have been identified they can be controlled. This article discusses the reasons for concern about the potential effects on health of exposure to nano-materials and relates these to the evidence of the effects on health of the ambient aerosol. A number of hypotheses are proposed and the dangers of adopting unsubstantiated hypotheses are stressed. Nano-toxicology presents many challenges and will need substantial financial support if it is to develop at a rate sufficient to cope with developments in nano-technology.

  5. Nano-technology and nano-toxicology

    PubMed Central

    Maynard, Robert L.

    2012-01-01

    Rapid developments in nano-technology are likely to confer significant benefits on mankind. But, as with perhaps all new technologies, these benefits are likely to be accompanied by risks, perhaps by new risks. Nano-toxicology is developing in parallel with nano-technology and seeks to define the hazards and risks associated with nano-materials: only when risks have been identified they can be controlled. This article discusses the reasons for concern about the potential effects on health of exposure to nano-materials and relates these to the evidence of the effects on health of the ambient aerosol. A number of hypotheses are proposed and the dangers of adopting unsubstantiated hypotheses are stressed. Nano-toxicology presents many challenges and will need substantial financial support if it is to develop at a rate sufficient to cope with developments in nano-technology. PMID:22662021

  6. Evaluation of in vivo and in vitro toxicological and genotoxic potential of aluminum chloride.

    PubMed

    Paz, Letícia Nazareth Fernandes; Moura, Laís Mesquita; Feio, Danielle Cristinne A; Cardoso, Mirella de Souza Gonçalves; Ximenes, Wagner Luiz O; Montenegro, Raquel C; Alves, Ana Paula N; Burbano, Rommel R; Lima, Patrícia Danielle L

    2017-05-01

    Aluminum and its compounds are common contaminants of water and food, as well as medications and cosmetics. The wide distribution of the element facilitates the demand for detailed studies of its biological and toxicological effects. This work aimed to evaluate the possible genotoxic and toxic activity resulting from in vivo and in vitro exposure to Al. For in vivo analysis, 40 Swiss mice were used, various concentrations of hydrated aluminum chloride were administered orally. They were analyzed for possible genic activity and metal cytotoxicity using a micronucleus test (MN), and for toxicity through histopathological evaluation of the extracted organs. For in vitro analysis, lymphocytes from the peripheral blood of 3 healthy donors were used. These cells were exposed to the same chemical agent in various concentrations. In vivo study revealed a significant increase in the number of MN in all Al concentrations. Furthermore, significant alterations in all the organs evaluated were verified by the presence of irreversible lesions (such as necrosis). Corroborating these findings, a significant increase in the quantity of MN in all concentrations with lymphocytes in vitro. In light of this, we suggest that this metal presents genotoxic potential and is potentially a cause of pathological disorders.

  7. Distribution, sources and potential toxicological significance of polycyclic aromatic hydrocarbons (PAHs) in surface soils of the Yellow River Delta, China.

    PubMed

    Yuan, Hongming; Li, Tiegang; Ding, Xigui; Zhao, Guangming; Ye, Siyuan

    2014-06-15

    PAH concentrations of 61 surface soil samples collected from the Yellow River Delta (YRD), China were measured to determine occurrence levels, sources, and potential toxicological significance of PAHs. The total concentrations of ∑PAHs ranged from 27 to 753 ng/g d.w., with a mean of 118±132 ng/g. The highest concentrations was found in the mid-southern part of the YRD (753 ng/g), which was associated with the oil exploration. The ratios indicated that the PAHs throughout the YRD were mostly of pyrogenic origin; while various sites in mid-southern part in the region were derived mainly from the petrogenic sources. Multivariate statistical analyses supported that the PAHs in surface soils of the YRD were principally from the coal and biomass combustion, petroleum spills, and/or vehicular emissions. The toxic assessment suggested that the PAHs in soils were at low potential of ecotoxicological contamination level for the YRD. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

  8. Comments on potential geologic and seismic hazards affecting coastal Ventura County, California

    USGS Publications Warehouse

    Ross, Stephanie L.; Boore, David M.; Fisher, Michael A.; Frankel, Arthur D.; Geist, Eric L.; Hudnut, Kenneth W.; Kayen, Robert E.; Lee, Homa J.; Normark, William R.; Wong, Florence L.

    2004-01-01

    This report examines the regional seismic and geologic hazards that could affect proposed liquefied natural gas (LNG) facilities in coastal Ventura County, California. Faults throughout this area are thought to be capable of producing earthquakes of magnitude 6.5 to 7.5, which could produce surface fault offsets of as much as 15 feet. Many of these faults are sufficiently well understood to be included in the current generation of the National Seismic Hazard Maps; others may become candidates for inclusion in future revisions as research proceeds. Strong shaking is the primary hazard that causes damage from earthquakes and this area is zoned with a high level of shaking hazard. The estimated probability of a magnitude 6.5 or larger earthquake (comparable in size to the 2003 San Simeon quake) occurring in the next 30 years within 30 miles of Platform Grace is 50-60%; for Cabrillo Port, the estimate is a 35% likelihood. Combining these probabilities of earthquake occurrence with relationships that give expected ground motions yields the estimated seismic-shaking hazard. In parts of the project area, the estimated shaking hazard is as high as along the San Andreas Fault. The combination of long-period basin waves and LNG installations with large long-period resonances potentially increases this hazard.

  9. Considering potential seismic sources in earthquake hazard assessment for Northern Iran

    NASA Astrophysics Data System (ADS)

    Abdollahzadeh, Gholamreza; Sazjini, Mohammad; Shahaky, Mohsen; Tajrishi, Fatemeh Zahedi; Khanmohammadi, Leila

    2014-07-01

    Located on the Alpine-Himalayan earthquake belt, Iran is one of the seismically active regions of the world. Northern Iran, south of Caspian Basin, a hazardous subduction zone, is a densely populated and developing area of the country. Historical and instrumental documented seismicity indicates the occurrence of severe earthquakes leading to many deaths and large losses in the region. With growth of seismological and tectonic data, updated seismic hazard assessment is a worthwhile issue in emergency management programs and long-term developing plans in urban and rural areas of this region. In the present study, being armed with up-to-date information required for seismic hazard assessment including geological data and active tectonic setting for thorough investigation of the active and potential seismogenic sources, and historical and instrumental events for compiling the earthquake catalogue, probabilistic seismic hazard assessment is carried out for the region using three recent ground motion prediction equations. The logic tree method is utilized to capture epistemic uncertainty of the seismic hazard assessment in delineation of the seismic sources and selection of attenuation relations. The results are compared to a recent practice in code-prescribed seismic hazard of the region and are discussed in detail to explore their variation in each branch of logic tree approach. Also, seismic hazard maps of peak ground acceleration in rock site for 475- and 2,475-year return periods are provided for the region.

  10. Listeria Species in Broiler Poultry Farms: Potential Public Health Hazards.

    PubMed

    Dahshan, Hesham; Merwad, Abdallah Mohamed Amin; Mohamed, Taisir Saber

    2016-09-28

    Broiler meat production worldwide has been plagued by lethal food-poisoning bacteria diseases, including listeriosis. A fatality rate of 15.6% was recorded in human beings in the EU in 2015. During 2013, a total of 200 poultry farm samples, including litter, chicken breast, farm feed, and drinking water, were collected to generate baseline data for the characterization of the genus Listeria in broiler poultry farms. Listeria spp. were detected in a total of 95 (47.5%) poultry farm samples. The isolates of Listeria spp. included L. innocua (28.5%), L. ivanovii (12.5%), L. welshimeri (4.5%), and L. monocytogenes and L. seeligeri (1% each). Listeria spp. contamination rates were higher in farm feed (70%), followed by litter (52.5%), chicken breasts (42.2%), and drinking water (10%). Almost all Listeria spp. isolates were resistant to more than three classes of antibiotics (multidrug resistant). Besides this, we observed a significant resistance level to penicillin and fluoroquinolone drugs. However, lower resistance levels were recorded for broad-spectrum cephalosporins. The inlA, inlC, and inlJ virulence genes were detected in almost all of the L. monocytogenes isolates. Thus, food safety management approaches and interventions at all stages of the broiler rearing cycle were needed to control cross-contamination and the zoonotic potential of listeriosis.

  11. Potential geologic hazards of North Aleutian shelf, Bristol Bay, Alaska

    SciTech Connect

    Molnia, B.F.; Schwab, W.C.

    1985-02-01

    Federal OSC lease sale 92, North Aleutian shelf, Alaska, is scheduled for April 1985. The area, located in the southeastern Bering Sea, has 3 basins with sedimentary thicknesses in excess of 4 km. Six geologic conditions that could cause problems during petroleum development are: (1) seismicity, (2) recent faulting, (3) gas-charged sediment, (4) bed forms and active sediment transport, (5) scours, and (6) volcanism. Since 1953, the region has a history of at least 10 shallow earthquakes, including a 1971 back-arc event with a Richter magnitude of 5.2. The largest event impacting the entire region, a Richter magnitude 8.7 earthquake, occurred in 1938. Normal faults are located along the southern edge of the St. George basin, and on the northeastern edge of the Amak basin. Many exhibit increased offset with depth, surficial sags, and small surficial cracks. Surprising was the absence of any evidence of sea-floor sediment instability. Sonar bright spots, and possible, near-surface gas-charged sediment occur west of Amak Island and north of Unimak Island. An area of megaripples and dunes covers more than 1500 km/sup 2/. Bed forms have spacings of 20-50 m and heights of 1-3 m. Observations suggest that coarse sand may be actively transported. Thousands of scours, many linear and parallel, some greater than 800 m long, 250 m wide, and incised up to 5 m, were identified. Pavlof, an Alaskan Peninsula active volcano, located 45 km northeast of Cold Bay, has a continuous history of steam release and occasional eruption. Lahars, nuee ardentes are unknown. None of the geologic conditions identified precludes petroleum development or production. The potential impact of these factors must, however, be included in planning for future petroleum activities.

  12. MR of ballistic materials: imaging artifacts and potential hazards.

    PubMed

    Smith, A S; Hurst, G C; Duerk, J L; Diaz, P J

    1991-01-01

    The most common ballistic materials available in the urban setting were studied for their MR effects on deflection force, rotation, heating, and imaging artifacts at 1.5 T to determine the potential efficacy and safety for imaging patients with ballistic injuries. The 28 missiles tested covered the range of bullet types and materials suggested by the Cleveland Police Department. The deflection force was measured by the New method. Rotation was evaluated 30 min after bullets had been placed in a 10% (weight per weight) ballistic gelatin designed to simulate brain tissue, with the long axis of the bullet placed parallel and perpendicular to the Z axis of the magnet. Heating was measured with alcohol thermometers by imaging for 1 hr alternatively with gradient-echo and spin-echo sequences (RF absorption = 0.033 and 0.326 w/kg respectively). Image artifacts on routine sequences were evaluated. All the steel-containing bullets except for the Winchester armor-piercing 38 caliber exhibited deflection. A nonsteel 7.38-mm Mauser also deflected. Deflection range was 514 to 15,504 dynes. Rotation occurred when the bullets were not parallel to the Z axis. Temperature changes were not significant. Deflecting projectiles resulted in obliteration of the image. The artifacts from other projectiles were small but varied by content. The artifact of the Winchester armor-piercing 38-caliber bullet was similar to those without steel. Bullets that contain steel or ferromagnetic contaminates such as nickel can be rotated within the MR unit.(ABSTRACT TRUNCATED AT 250 WORDS)

  13. Antiglycation, antioxidant and toxicological potential of polyphenol extracts of alligator pepper, ginger and nutmeg from Nigeria

    PubMed Central

    Kazeem, MI; Akanji, MA; Hafizur, Rahman M; Choudhary, MI

    2012-01-01

    Objective To evaluate the antioxidant and antiglycation potential of polyphenols from three spices; alligator pepper, ginger and nutmeg. Methods Polyphenol extracts of these spices were subjected to brine-shrimp lethality assay, phytotoxicity test, DPPH and superoxide anion radical scavenging as well as BSA-glucose antiglycation assay. Results Results obtained showed that polyphenol extract of ginger has the highest antioxidant potential with IC50 0.075 and 0.070 mg/mL for DPPH and superoxide anion radical scavenging assay while alligator pepper displayed highest antiglycation activity with IC50 0.125 mg/mL. However, nutmeg extract exhibited weakest cytotoxic and phytotoxic potential with LD50 4359.70 and 1490 µg/mL respectively. Conclusions It can be concluded that the polyphenol extracts of alligator pepper, ginger and nutmeg displayed good antioxidant as well as antiglycation potential and are safe for consumption. PMID:23570003

  14. Antiglycation, antioxidant and toxicological potential of polyphenol extracts of alligator pepper, ginger and nutmeg from Nigeria.

    PubMed

    Kazeem, M I; Akanji, M A; Hafizur, Rahman M; Choudhary, M I

    2012-09-01

    To evaluate the antioxidant and antiglycation potential of polyphenols from three spices; alligator pepper, ginger and nutmeg. Polyphenol extracts of these spices were subjected to brine-shrimp lethality assay, phytotoxicity test, DPPH and superoxide anion radical scavenging as well as BSA-glucose antiglycation assay. Results obtained showed that polyphenol extract of ginger has the highest antioxidant potential with IC50 0.075 and 0.070 mg/mL for DPPH and superoxide anion radical scavenging assay while alligator pepper displayed highest antiglycation activity with IC50 0.125 mg/mL. However, nutmeg extract exhibited weakest cytotoxic and phytotoxic potential with LD50 4359.70 and 1490 µg/mL respectively. It can be concluded that the polyphenol extracts of alligator pepper, ginger and nutmeg displayed good antioxidant as well as antiglycation potential and are safe for consumption.

  15. Enhancing high throughput toxicology - development of putative adverse outcome pathways linking US EPA ToxCast screening targets to relevant apical hazards.

    EPA Science Inventory

    High throughput toxicology programs, such as ToxCast and Tox21, have provided biological effects data for thousands of chemicals at multiple concentrations. Compared to traditional, whole-organism approaches, high throughput assays are rapid and cost-effective, yet they generall...

  16. Enhancing high throughput toxicology - development of putative adverse outcome pathways linking US EPA ToxCast screening targets to relevant apical hazards.

    EPA Science Inventory

    High throughput toxicology programs, such as ToxCast and Tox21, have provided biological effects data for thousands of chemicals at multiple concentrations. Compared to traditional, whole-organism approaches, high throughput assays are rapid and cost-effective, yet they generall...

  17. Development of a GIS for environmental assessment incorporating known potential environmental hazards and remote sensing

    SciTech Connect

    Shaffer, D.L.; Roth, M.J.S.; Ruggles, R.

    1996-12-31

    The development of a Geographic Information System (GIS) application to evaluate potential environmental hazards within the Bushkill watershed in Northampton County, Pennsylvania, is described by the authors. Information identifying hazardous materials used by businesses within the watershed was obtained from databases of the Environmental Protection Agency. These databases were supplemented and updated by visual reconnaissance and by a review of current tax maps, zoning information and aerial photographs. Information regarding the use or storage of substances considered hazardous was collected from various agencies as well as any known violations of environmental regulations by the businesses. Geographic information including remotely sensed data and maps of surface water bodies, geology and soil types was also obtained for the study area. A GIS was used to integrate the geographic information with the hazardous substance database resulting in a tool for use in environmental site assessments, planning for subsequent site characterization, and for environmental educational purposes.

  18. Continuous injection of an inert gas through a drill rig for drilling into potentially hazardous areas

    SciTech Connect

    McCormick, S.H.; Pigott, W.R.

    1998-04-01

    A drill rig for drilling in potentially hazardous areas includes a drill having conventional features such as a frame, a gear motor, gear box, and a drive. A hollow rotating shaft projects through the drive and frame. An auger, connected to the shaft is provided with a multiplicity of holes. An inert gas is supplied to the hollow shaft and directed from the rotating shaft to the holes in the auger. The inert gas flows down the hollow shaft, and then down the hollow auger, and out through the holes in the bottom of the auger into the potentially hazardous area.

  19. Continuous injection of an inert gas through a drill rig for drilling into potentially hazardous areas

    DOEpatents

    McCormick, Steve H.; Pigott, William R.

    1997-01-01

    A drill rig for drilling in potentially hazardous areas includes a drill having conventional features such as a frame, a gear motor, gear box, and a drive. A hollow rotating shaft projects through the drive and frame. An auger, connected to the shaft is provided with a multiplicity of holes. An inert gas is supplied to the hollow shaft and directed from the rotating shaft to the holes in the auger. The inert gas flows down the hollow shaft, and then down the hollow auger and out through the holes in the bottom of the auger into the potentially hazardous area.

  20. Continuous injection of an inert gas through a drill rig for drilling into potentially hazardous areas

    DOEpatents

    McCormick, S.H.; Pigott, W.R.

    1997-12-30

    A drill rig for drilling in potentially hazardous areas includes a drill having conventional features such as a frame, a gear motor, gear box, and a drive. A hollow rotating shaft projects through the drive and frame. An auger, connected to the shaft is provided with a multiplicity of holes. An inert gas is supplied to the hollow shaft and directed from the rotating shaft to the holes in the auger. The inert gas flows down the hollow shaft, and then down the hollow auger and out through the holes in the bottom of the auger into the potentially hazardous area. 3 figs.

  1. Characterization and validation of an in silico toxicology model to predict the mutagenic potential of drug impurities.

    PubMed

    Valerio, Luis G; Cross, Kevin P

    2012-05-01

    Control and minimization of human exposure to potential genotoxic impurities found in drug substances and products is an important part of preclinical safety assessments of new drug products. The FDA's 2008 draft guidance on genotoxic and carcinogenic impurities in drug substances and products allows use of computational quantitative structure-activity relationships (QSAR) to identify structural alerts for known and expected impurities present at levels below qualified thresholds. This study provides the information necessary to establish the practical use of a new in silico toxicology model for predicting Salmonella t. mutagenicity (Ames assay outcome) of drug impurities and other chemicals. We describe the model's chemical content and toxicity fingerprint in terms of compound space, molecular and structural toxicophores, and have rigorously tested its predictive power using both cross-validation and external validation experiments, as well as case studies. Consistent with desired regulatory use, the model performs with high sensitivity (81%) and high negative predictivity (81%) based on external validation with 2368 compounds foreign to the model and having known mutagenicity. A database of drug impurities was created from proprietary FDA submissions and the public literature which found significant overlap between the structural features of drug impurities and training set chemicals in the QSAR model. Overall, the model's predictive performance was found to be acceptable for screening drug impurities for Salmonella mutagenicity.

  2. Computational Toxicology

    EPA Science Inventory

    ‘Computational toxicology’ is a broad term that encompasses all manner of computer-facilitated informatics, data-mining, and modeling endeavors in relation to toxicology, including exposure modeling, physiologically based pharmacokinetic (PBPK) modeling, dose-response modeling, ...

  3. Computational Toxicology

    EPA Science Inventory

    ‘Computational toxicology’ is a broad term that encompasses all manner of computer-facilitated informatics, data-mining, and modeling endeavors in relation to toxicology, including exposure modeling, physiologically based pharmacokinetic (PBPK) modeling, dose-response modeling, ...

  4. Perfluoroalkyl acids: a review of monitoring and toxicological findings.

    PubMed

    Lau, Christopher; Anitole, Katherine; Hodes, Colette; Lai, David; Pfahles-Hutchens, Andrea; Seed, Jennifer

    2007-10-01

    In recent years, human and wildlife monitoring studies have identified perfluoroalkyl acids (PFAA) worldwide. This has led to efforts to better understand the hazards that may be inherent in these compounds, as well as the global distribution of the PFAAs. Much attention has focused on understanding the toxicology of the two most widely known PFAAs, perfluorooctanoic acid, and perfluorooctane sulfate. More recently, research was extended to other PFAAs. There has been substantial progress in understanding additional aspects of the toxicology of these compounds, particularly related to the developmental toxicity, immunotoxicity, hepatotoxicity, and the potential modes of action. This review provides an overview of the recent advances in the toxicology and mode of action for PFAAs, and of the monitoring data now available for the environment, wildlife, and humans. Several avenues of research are proposed that would further our understanding of this class of compounds.

  5. THE FUTURE OF TOXICOLOGY-PREDICTIVE TOXICOLOGY ...

    EPA Pesticide Factsheets

    A chemistry approach to predictive toxicology relies on structure−activity relationship (SAR) modeling to predict biological activity from chemical structure. Such approaches have proven capabilities when applied to well-defined toxicity end points or regions of chemical space. These approaches are less well-suited, however, to the challenges of global toxicity prediction, i.e., to predicting the potential toxicity of structurally diverse chemicals across a wide range of end points of regulatory and pharmaceutical concern. New approaches that have the potential to significantly improve capabilities in predictive toxicology are elaborating the “activity” portion of the SAR paradigm. Recent advances in two areas of endeavor are particularly promising. Toxicity data informatics relies on standardized data schema, developed for particular areas of toxicological study, to facilitate data integration and enable relational exploration and mining of data across both historical and new areas of toxicological investigation. Bioassay profiling refers to large-scale high-throughput screening approaches that use chemicals as probes to broadly characterize biological response space, extending the concept of chemical “properties” to the biological activity domain. The effective capture and representation of legacy and new toxicity data into mineable form and the large-scale generation of new bioassay data in relation to chemical toxicity, both employing chemical stru

  6. [Genetically modified organisms (GMO): toxicological aspects].

    PubMed

    Ludwicki, J K

    1998-01-01

    The genetically modified organisms (GMO) are one of the major public concerns partially due to the activity of the non-governmental organizations which believe that public opinion must be duly informed on what leaves the laboratories and enters the environment or is proposed as food. This article discusses some major toxicological and nutritional aspects of GMO designed as food for humans. The range of current use of GMOs, potential hazards for humans, safety assessment, allergenic concerns, and some aspects of the use of marker genes are discussed in regard to human safety. The need for relevant regulations is stressed.

  7. Potential for a hazardous geospheric response to projected future climate changes.

    PubMed

    McGuire, B

    2010-05-28

    Periods of exceptional climate change in Earth history are associated with a dynamic response from the geosphere, involving enhanced levels of potentially hazardous geological and geomorphological activity. The response is expressed through the adjustment, modulation or triggering of a broad range of surface and crustal phenomena, including volcanic and seismic activity, submarine and subaerial landslides, tsunamis and landslide 'splash' waves, glacial outburst and rock-dam failure floods, debris flows and gas-hydrate destabilization. In relation to anthropogenic climate change, modelling studies and projection of current trends point towards increased risk in relation to a spectrum of geological and geomorphological hazards in a warmer world, while observations suggest that the ongoing rise in global average temperatures may already be eliciting a hazardous response from the geosphere. Here, the potential influences of anthropogenic warming are reviewed in relation to an array of geological and geomorphological hazards across a range of environmental settings. A programme of focused research is advocated in order to: (i) understand better those mechanisms by which contemporary climate change may drive hazardous geological and geomorphological activity; (ii) delineate those parts of the world that are most susceptible; and (iii) provide a more robust appreciation of potential impacts for society and infrastructure.

  8. A toxicological review of the propylene glycols.

    PubMed

    Fowles, Jeff R; Banton, Marcy I; Pottenger, Lynn H

    2013-04-01

    The toxicological profiles of monopropylene glycol (MPG), dipropylene glycol (DPG), tripropylene glycol (TPG) and polypropylene glycols (PPG; including tetra-rich oligomers) are collectively reviewed, and assessed considering regulatory toxicology endpoints. The review confirms a rich data set for these compounds, covering all of the major toxicological endpoints of interest. The metabolism of these compounds share common pathways, and a consistent profile of toxicity is observed. The common metabolism provides scientific justification for adopting a read-across approach to describing expected hazard potential from data gaps that may exist for specific oligomers. None of the glycols reviewed presented evidence of carcinogenic, mutagenic or reproductive/developmental toxicity potential to humans. The pathologies reported in some animal studies either occurred at doses that exceeded experimental guidelines, or involved mechanisms that are likely irrelevant to human physiology and therefore are not pertinent to the exposures experienced by consumers or workers. At very high chronic doses, MPG causes a transient, slight decrease in hemoglobin in dogs and at somewhat lower doses causes Heinz bodies to form in cats in the absence of any clinical signs of anemia. Some evidence for rare, idiosyncratic skin reactions exists for MPG. However, the larger data set indicates that these compounds have low sensitization potential in animal studies, and therefore are unlikely to represent human allergens. The existing safety evaluations of the FDA, USEPA, NTP and ATSDR for these compounds are consistent and point to the conclusion that the propylene glycols present a very low risk to human health.

  9. Spatial identification of potential health hazards: a systematic areal search approach.

    PubMed

    Svechkina, Alina; Zusman, Marina; Rybnikova, Natalya; Portnov, Boris A

    2017-02-07

    Large metropolitan areas often exhibit multiple morbidity hotspots. However, the identification of specific health hazards, associated with the observed morbidity patterns, is not always straightforward. In this study, we suggest an empirical approach to the identification of specific health hazards, which have the highest probability of association with the observed morbidity patterns. The morbidity effect of a particular health hazard is expected to weaken with distance. To account for this effect, we estimate distance decay gradients for alternative locations and then rank these locations based on the strength of association between the observed morbidity and wind-direction weighted proximities to these locations. To validate this approach, we use both theoretical examples and a case study of the Greater Haifa Metropolitan Area (GHMA) in Israel, which is characterized by multiple health hazards. In our theoretical examples, the proposed approach helped to identify correctly the predefined locations of health hazards, while in the real-world case study, the main health hazard was identified as a spot in the industrial zone, which hosts several petrochemical facilities. The proposed approach does not require extensive input information and can be used as a preliminary risk assessment tool in a wide range of environmental settings, helping to identify potential environmental risk factors behind the observed population morbidity patterns.

  10. Potential of weight of evidence modelling for gully erosion hazard assessment in Mbire District - Zimbabwe

    NASA Astrophysics Data System (ADS)

    Dube, F.; Nhapi, I.; Murwira, A.; Gumindoga, W.; Goldin, J.; Mashauri, D. A.

    Gully erosion is an environmental concern particularly in areas where landcover has been modified by human activities. This study assessed the extent to which the potential of gully erosion could be successfully modelled as a function of seven environmental factors (landcover, soil type, distance from river, distance from road, Sediment Transport Index (STI), Stream Power Index (SPI) and Wetness Index (WI) using a GIS-based Weight of Evidence Modelling (WEM) in the Mbire District of Zimbabwe. Results show that out of the studied seven factors affecting gully erosion, five were significantly correlated (p < 0.05) to gully occurrence, namely; landcover, soil type, distance from river, STI and SPI. Two factors; WI and distance from road were not significantly correlated to gully occurrence (p > 0.05). A gully erosion hazard map showed that 78% of the very high hazard class area is within a distance of 250 m from rivers. Model validation indicated that 70% of the validation set of gullies were in the high hazard and very high hazard class. The resulting map of areas susceptible to gully erosion has a prediction accuracy of 67.8%. The predictive capability of the weight of evidence model in this study suggests that landcover, soil type, distance from river, STI and SPI are useful in creating a gully erosion hazard map but may not be sufficient to produce a valid map of gully erosion hazard.

  11. Toxicological benchmarks for screening potential contaminants of concern for effects on aquatic biota: 1996 revision

    SciTech Connect

    Suter, G.W. II; Tsao, C.L.

    1996-06-01

    This report presents potential screening benchmarks for protection of aquatic life form contaminants in water. Because there is no guidance for screening for benchmarks, a set of alternative benchmarks is presented herein. This report presents the alternative benchmarks for chemicals that have been detected on the Oak Ridge Reservation. It also presents the data used to calculate the benchmarks and the sources of the data. It compares the benchmarks and discusses their relative conservatism and utility. Also included is the updates of benchmark values where appropriate, new benchmark values, secondary sources are replaced by primary sources, and a more complete documentation of the sources and derivation of all values are presented.

  12. New method for assessing the potential hazardousness of glacial lakes in the Cordillera Blanca, Peru

    NASA Astrophysics Data System (ADS)

    Emmer, A.; Vilímek, V.

    2014-02-01

    This paper presents a new and easily repeatable objective method for assessing the potential hazardousness of glacial lakes within the Peruvian region of Cordillera Blanca (excluding ice-dammed lakes, which do not reach significant volumes in this region). The presented method was designed to meet four basic principles, which we considered as being crucial. These are: (a) principle of regional focus; (b) principle of objectivity; (c) principle of repeatability; and (d) principle of multiple results. Potential hazardousness is assessed based on a combination of decision trees for clarity and numerical calculation for objectivity. A total of seventeen assessed characteristics are used, of which seven have yet to be used in this context before. Also, several ratios and calculations are defined for the first time. We assume that it is not relevant to represent the overall potential hazardousness of a particular lake by one result (number), thus the potential hazardousness is described in the presented method by five separate results (representing five different glacial lake outburst flood scenarios). These are potentials for: (a) dam overtopping resulting from a dynamic slope movement into the lake; (b) dam overtopping following the flood wave originating in a lake situated upstream; (c) dam failure resulting from a dynamic slope movement into the lake; (d) dam failure following the flood wave originating in a lake situated upstream; and (e) dam failure following a heavy earthquake. All of these potentials theoretically range from 0 to 1. The presented method was verified on the basis of assessing the pre-flood conditions of seven lakes which have produced ten glacial lake outburst floods in the past and ten lakes which have not. A comparison of these results showed that the presented method successfully identifies the potentially hazardous lakes.

  13. Toxicologic assessment of Paecilomyces tenuipes in rats: renal toxicity and mutagenic potential.

    PubMed

    Che, Jeong-Hwan; Yun, Jun-Won; Cho, Eun-Young; Kim, Seung-Hyun; Kim, Yun-Soon; Kim, Woo Ho; Park, Jae-Hak; Son, Woo-Chan; Kim, Mi Kyung; Kang, Byeong-Cheol

    2014-11-01

    Paecilomyces tenuipes is entomogenous fungus that is called snow-flake Dongchunghacho in Korea. Although it is widely used in traditional medicines, its safety has not yet been comprehensively investigated. Therefore, the aim of this study was to evaluate the genotoxicity, acute and subchronic toxicity of P. tenuipes. The acute oral LD50 of P. tenuipes extract in rats was estimated to be greater than 2000mg/kg of body weight. In the subchronic study, the oral treatment of rats with 500, 1000 or 2000mg/kg P. tenuipes extract daily for 13weeks did not induce any dose-related changes (body weight, food consumption, clinical observation, urinalysis, hematology, clinical chemistry and organ weight). In contrast, histopathological observation revealed that P. tenuipes extract induced karyomegaly in outer medulla of kidney in all treated rats. Importantly, P. tenuipes extract exerted the mutagenic potential in Ames assay. Since karyomegalic alterations have been known to be associated with carcinogenicity, our finding on the mutagenicity of P. tenuipes extract supports the possibility on the potential involvement of P. tenuipes in carcinogenicity at least partially. In conclusion, the subchronic oral exposure of P. tenuipes may induce kidney abnormality at the concentration higher than 500mg/kg body weight, although further studies using other animal models are needed to identify the toxicity of P. tenuipes. Copyright © 2014 Elsevier Inc. All rights reserved.

  14. Incorporating exposure information into the toxicological prioritization index decision support framework

    EPA Science Inventory

    The Toxicological Prioritization Index (ToxPi) decision support framework was previously developed to facilitate incorporation of diverse data to prioritize chemicals based on potential hazard. This ToxPi index was demonstrated by considering results of bioprofiling related to po...

  15. Incorporating exposure information into the toxicological prioritization index decision support framework

    EPA Science Inventory

    The Toxicological Prioritization Index (ToxPi) decision support framework was previously developed to facilitate incorporation of diverse data to prioritize chemicals based on potential hazard. This ToxPi index was demonstrated by considering results of bioprofiling related to po...

  16. Identification of potentially hazardous human gene products in GMO risk assessment.

    PubMed

    Bergmans, Hans; Logie, Colin; Van Maanen, Kees; Hermsen, Harm; Meredyth, Michelle; Van Der Vlugt, Cécile

    2008-01-01

    Genetically modified organisms (GMOs), e.g. viral vectors, could threaten the environment if by their release they spread hazardous gene products. Even in contained use, to prevent adverse consequences, viral vectors carrying genes from mammals or humans should be especially scrutinized as to whether gene products that they synthesize could be hazardous in their new context. Examples of such potentially hazardous gene products (PHGPs) are: protein toxins, products of dominant alleles that have a role in hereditary diseases, gene products and sequences involved in genome rearrangements, gene products involved in immunomodulation or with an endocrine function, gene products involved in apoptosis, activated proto-oncogenes. For contained use of a GMO that carries a construct encoding a PHGP, the precautionary principle dictates that safety measures should be applied on a "worst case" basis, until the risks of the specific case have been assessed. The potential hazard of cloned genes can be estimated before empirical data on the actual GMO become available. Preliminary data may be used to focus hazard identification and risk assessment. Both predictive and empirical data may also help to identify what further information is needed to assess the risk of the GMO. A two-step approach, whereby a PHGP is evaluated for its conceptual dangers, then checked by data bank searches, is delineated here.

  17. Mercury exposure on potential plant Ludwigia octovalvis L. - Preliminary toxicological testing

    NASA Astrophysics Data System (ADS)

    Alrawiq, Huda S. M.; Mushrifah, I.

    2013-11-01

    The preliminary test in phytoremediation is necessaryto determine the ability of plant to survive in media with different concentrations of contaminant. It was conducted to determine the maximum concentration of the contaminant that isharmful to the plant and suppress the plant growth. This study showed the ability of Ludwigia octovalvisto resist mercury (Hg) contaminant in sand containing different concentrations of Hg (0, 0.5, 1, 2, 4, 6 and 8 mg/L). The experimental work wasperformed under greenhouse conditions for an observation period of 4 weeks. Throughout the 4 weeks duration, the resultsshowed that 66.66% of the plants withered for on exposure to Hg concentration of 4 mg/L and 100% withered at higher concentrations of 6 and 8 mg/L. The results of this study may serve as a basis for research that aims to study uptake and accumulation of Hg using potential phytoremediation plants.

  18. Computational Toxicology at the US EPA

    EPA Science Inventory

    Computational toxicology is the application of mathematical and computer models to help assess chemical hazards and risks to human health and the environment. Supported by advances in informatics, high-throughput screening (HTS) technologies, and systems biology, EPA is developin...

  19. Computational Toxicology at the US EPA

    EPA Science Inventory

    Computational toxicology is the application of mathematical and computer models to help assess chemical hazards and risks to human health and the environment. Supported by advances in informatics, high-throughput screening (HTS) technologies, and systems biology, EPA is developin...

  20. Estimation of hazard potentials from ice avalanches using remote sensing and GIS-modelling

    NASA Astrophysics Data System (ADS)

    Salzmann, N.; Kaeaeb, A.; Huggel, C.; Allgoewer, B.; Haeberli, W.

    2003-04-01

    Ice avalanches occur when a large mass of ice breaks off from steep glaciers. Due to the usually low reach of ice avalanches, their hazard potentials are generally restricted to high mountain areas with dense population or under frequent touristic use. But in consequence of climatic changes and intensified land use, the related hazard potentials are presently increasing. Therefore, dealing with ice-avalanche hazards requires a robust tool for systematic area-wide detection of potential ice avalanches, that has not been developed so far. To close this gap, a three-step downscaling approach was developed. The method-chain is based on statistical parameters and techniques of GIS-modelling and remote sensing. The procedure allows a fast and systematic first-order mapping of potentially dangerous steep glaciers and their runout paths for an entire region (focus map scale 1:10'000 - 1:25'000). The validation of the approach was carried out in the Bernese Alps, Switzerland. The results agree well with other specific hazard mapping realised in the same area by other authors. Furthermore, improvements can be obtained by expanding the method-chain and with more accurate base data (especially satellite data) available in the near future.

  1. 14 CFR 121.561 - Reporting potentially hazardous meteorological conditions and irregularities of ground facilities...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Reporting potentially hazardous meteorological conditions and irregularities of ground facilities or navigation aids. 121.561 Section 121.561... meteorological conditions and irregularities of ground facilities or navigation aids. (a) Whenever he...

  2. 14 CFR 121.561 - Reporting potentially hazardous meteorological conditions and irregularities of ground facilities...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Reporting potentially hazardous meteorological conditions and irregularities of ground facilities or navigation aids. 121.561 Section 121.561... meteorological conditions and irregularities of ground facilities or navigation aids. (a) Whenever he...

  3. 14 CFR 121.561 - Reporting potentially hazardous meteorological conditions and irregularities of ground facilities...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Reporting potentially hazardous meteorological conditions and irregularities of ground facilities or navigation aids. 121.561 Section 121.561... meteorological conditions and irregularities of ground facilities or navigation aids. (a) Whenever he...

  4. 14 CFR 121.561 - Reporting potentially hazardous meteorological conditions and irregularities of ground facilities...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Reporting potentially hazardous meteorological conditions and irregularities of ground facilities or navigation aids. 121.561 Section 121.561... meteorological conditions and irregularities of ground facilities or navigation aids. (a) Whenever he...

  5. 14 CFR 121.561 - Reporting potentially hazardous meteorological conditions and irregularities of ground facilities...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Reporting potentially hazardous meteorological conditions and irregularities of ground facilities or navigation aids. 121.561 Section 121.561... meteorological conditions and irregularities of ground facilities or navigation aids. (a) Whenever he...

  6. THE POTENTIAL OF AN EARTHWORM AVOIDANCE TEST FOR EVALUATION OF HAZARDOUS WASTE SITES

    EPA Science Inventory

    An earthworm avoidance test has potential advantages for use in evaluation of hazardous wastes sites. Because organisms often exhibit behavioral responses at lower levels of stress than those that acute toxicity tests are able to detect, avoidance tests could provide increased se...

  7. THE POTENTIAL OF AN EARTHWORM AVOIDANCE TEST FOR EVALUATION OF HAZARDOUS WASTE SITES

    EPA Science Inventory

    An earthworm avoidance test has potential advantages for use in evaluation of hazardous wastes sites. Because organisms often exhibit behavioral responses at lower levels of stress than those that acute toxicity tests are able to detect, avoidance tests could provide increased se...

  8. 47 CFR 80.83 - Protection from potentially hazardous RF radiation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... radiation. 80.83 Section 80.83 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND... Requirements-Ship Stations § 80.83 Protection from potentially hazardous RF radiation. Any license or renewal application for a ship earth station that will cause exposure to radiofrequency (RF) radiation in excess of...

  9. 47 CFR 80.83 - Protection from potentially hazardous RF radiation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... radiation. 80.83 Section 80.83 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND... Requirements-Ship Stations § 80.83 Protection from potentially hazardous RF radiation. Any license or renewal application for a ship earth station that will cause exposure to radiofrequency (RF) radiation in excess of...

  10. 47 CFR 80.83 - Protection from potentially hazardous RF radiation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... radiation. 80.83 Section 80.83 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND... Requirements-Ship Stations § 80.83 Protection from potentially hazardous RF radiation. Any license or renewal application for a ship earth station that will cause exposure to radiofrequency (RF) radiation in excess of...

  11. 47 CFR 80.83 - Protection from potentially hazardous RF radiation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... radiation. 80.83 Section 80.83 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND... Requirements-Ship Stations § 80.83 Protection from potentially hazardous RF radiation. Any license or renewal application for a ship earth station that will cause exposure to radiofrequency (RF) radiation in excess of...

  12. 47 CFR 80.83 - Protection from potentially hazardous RF radiation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... radiation. 80.83 Section 80.83 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND... Requirements-Ship Stations § 80.83 Protection from potentially hazardous RF radiation. Any license or renewal application for a ship earth station that will cause exposure to radiofrequency (RF) radiation in excess of...

  13. Assessment of potential toxicological aspects of dietary exposure to silicon-rich spirulina in rats.

    PubMed

    Vidé, Joris; Romain, Cindy; Feillet-Coudray, Christine; Bonafos, Béatrice; Cristol, Jean Paul; Fouret, Gilles; Rouanet, Jean-Max; Gaillet, Sylvie

    2015-06-01

    Silicon has beneficial effects especially on bones and skin and is important in cardiovascular pathophysiology. Furthermore, in spontaneously hypertensive rats, it reduces hypertension and increases antihypertensive and antiatherogenic gene expressions in the aorta. Thus, incorporating silicon into spirulina could be a way to produce a bioavailable food supplement. The potential toxic effects of silicon-rich spirulina (SES) through haematological and biochemical parameters and inflammatory and oxidative status were evaluated in rats' blood and liver tissue. The study consisted in a 90-day experiment on female and male rats supplemented with three doses (28.5, 57 and 285 mg/kg BW/day) of SES. No mortality, abnormal clinical signs, behavioural changes or macroscopic findings were observed whatever the groups. Haematological parameters were not modified in SES treated-groups. No marked change was recorded in biochemical parameters The liver endogenous antioxidant enzymes (SOD, GPx, catalase) activities were not modified whatever the gender and the dose, just as markers of oxidative stress (O2°(-), TBARS, thiols) and inflammation such as IL-6 and TNF-alpha. Our findings indicate that dietary supplementation of silicon-rich spirulina on rats has no harmful side nor toxic effects and could be beneficial especially in the case of suspicion or installation of pathologies due to oxidative stress. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. The international register of potentially toxic chemicals : Challenges of data collection in the field of toxicology.

    PubMed

    Caroli, S; Menditto, A; Chiodo, F

    1996-06-01

    The benefits and drawbacks consequent to the widespread use of chemicals are inextricably interwoven. According to recent estimates, more than 8 million substances are presently known, 70,000 of which are in common use as industrial compounds, pesticides, Pharmaceuticals, food additives, cosmetics and the like. It is estimated that substances used as such will increase annually by 1000 in number. The deleterious consequences deriving from their exploitation pose tremendous challenges to the scientific community for the protection of human health and the environment. Therefore it is of utmost priority to appropriately select valid information generated in this investigation area and to convey it correctly to users. Here, the adoption of the principles of good laboratory practice in experimental activities is essential, as well as the creation of global networks for data exchange on the safe use of chemicals. The structure and goals of the International Register of Potentially Toxic Chemicals (IRPTC, the database of the United Nations Environment Programme) are detailed to give an example of such an undertaking. Seventeen fields are covered,i.e. identifiers, properties and classification, production/trade, production processes, use, pathways into the environment, concentrations, environmental fate tests, environmental fate, chemobiokinetics, mammalian toxicity, special toxicity studies, effects on organisms in the environment, sampling/preparation/analysis, spills, treatment of poisoning, waste management and recommendations/legal mechanisms.

  15. Studies of the toxicological potential of capsinoids: V. Genotoxicity studies of dihydrocapsiate.

    PubMed

    Bernard, Bruce K; Watanabe, Eri; Kodama, Terutaka; Tsubuku, Shoji; Otabe, Akira; Nakajima, Madoka; Masumori, Shoji; Shimada, Sawako; Tanaka, Jin; Masuyama, Takeshi

    2008-01-01

    A series of studies was performed to evaluate the safety of dihydrocapsiate (4-hydroxy-3-methoxybenzyl 8-methylnonanoate; CAS no. 205687-03-2). This study evaluated the potential genotoxicity of this compound using a variety of in vitro and in vivo test systems, including bacterial reverse mutation test, chromosomal aberration test, micronucleus test, gene mutation assay with transgenic rats, and single-cell gel (SCG) assay (Comet assay). In vitro tests (bacterial reverse mutation test and chromosomal aberration test) produced positive results in the absence of metabolic activation, but negative results in the presence of metabolic activation. The in vivo gene mutation assay (with transgenic rats) produced negative results, as did the in vivo mouse micronucleus assay, which failed to induce micronucleated polychromatic erythrocytes. Although the rat SCG assay produced statistically significant increases in the Olive tail moment and % tail DNA of the liver and intestine in the 2000 mg/kg group (compared with the negative-control group), a number of factors caused the authors to question the validity of these findings. Taken together, these results suggest that dihydrocapsiate has a low or extremely low likelihood of inducing genotoxicity.

  16. Toxicological benchmarks for screening potential contaminants of concern for effects on aquatic biota: 1994 Revision

    SciTech Connect

    Suter, G.W. II; Mabrey, J.B.

    1994-07-01

    This report presents potential screening benchmarks for protection of aquatic life from contaminants in water. Because there is no guidance for screening benchmarks, a set of alternative benchmarks is presented herein. The alternative benchmarks are based on different conceptual approaches to estimating concentrations causing significant effects. For the upper screening benchmark, there are the acute National Ambient Water Quality Criteria (NAWQC) and the Secondary Acute Values (SAV). The SAV concentrations are values estimated with 80% confidence not to exceed the unknown acute NAWQC for those chemicals with no NAWQC. The alternative chronic benchmarks are the chronic NAWQC, the Secondary Chronic Value (SCV), the lowest chronic values for fish and daphnids from chronic toxicity tests, the estimated EC20 for a sensitive species, and the concentration estimated to cause a 20% reduction in the recruit abundance of largemouth bass. It is recommended that ambient chemical concentrations be compared to all of these benchmarks. If NAWQC are exceeded, the chemicals must be contaminants of concern because the NAWQC are applicable or relevant and appropriate requirements (ARARs). If NAWQC are not exceeded, but other benchmarks are, contaminants should be selected on the basis of the number of benchmarks exceeded and the conservatism of the particular benchmark values, as discussed in the text. To the extent that toxicity data are available, this report presents the alternative benchmarks for chemicals that have been detected on the Oak Ridge Reservation. It also presents the data used to calculate benchmarks and the sources of the data. It compares the benchmarks and discusses their relative conservatism and utility.

  17. Hematological and toxicological evaluation of formaldehyde as a potential cause of human leukemia.

    PubMed

    Goldstein, Bernard D

    2011-07-01

    Epidemiological findings suggesting that formaldehyde exposure is associated with a higher risk of acute myelogenous leukemia (AML) and other hematological cancers have led to consideration of the potential mechanism of action by which inhalation of this rapidly reactive agent can cause bone marrow cancer. Two major mechanism-based arguments against formaldehyde as a leukemogen have been the difficulty in envisioning how inhaled formaldehyde might penetrate to the bone marrow; and the lack of similarity of non-cancer effects to other known human myeloleukemogens, particularly the absence of pancytopenia in humans or laboratory animals exposed to high levels. However, both of these arguments have been addressed by the recent finding of a pancytopenic effect and chromosomal abnormalities in heavily exposed Chinese workers which, if replicated, are indicative of a genotoxic effect of formaldehyde on hematopoietic stem cells that is in keeping with other known human leukemogens. Review of the body of evidence suggests an apparent discrepancy between studies in laboratory animals, which generally fail to show evidence of penetration of formaldehyde into the blood or evidence of blood or bone marrow genotoxicity, and studies of exposed humans in which there tends to be evidence of genotoxicity in circulating blood cells. One possible explanation for this discrepancy is species difference. Another possible explanation is that myeloid precursors within the nasal mucosa may be the site for leukemogenesis. However, chloromas, which are local collections of myeloid tumor cells, are rarely if ever found in the nose. Other proposed mechanisms for formaldehyde leukemogenesis are reviewed, and dose issues at the interface between the epidemiological and hematotoxicological findings are explored.

  18. IRIS Toxicological Review of Ammonia (Interagency Science ...

    EPA Pesticide Factsheets

    On June 1, 2012, the draft Toxicological Review of Ammonia and the draft charge to external peer reviewers were released for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Offices before public release. Consistent with the May 2009 IRIS assessment development process, all written comments on IRIS assessments submitted by other federal agencies and White House Offices are made publicly available. Accordingly, interagency comments and the interagency science consultation materials provided to other agencies, including interagency review drafts of the IRIS Toxicological Review of Ammonia and the charge to external peer reviewers, are posted on this site. EPA is undertaking an Integrated Risk Information System (IRIS) health assessment for ammonia. IRIS is an EPA database containing Agency scientific positions on potential adverse human health effects that may result from chronic (or lifetime) exposure to chemicals in the environment. IRIS contains chemical-specific summaries of qualitative and quantitative health information in support of two steps of the risk assessment paradigm, i.e., hazard identification and dose-response evaluation. IRIS assessments are used in combination with specific situational exposure assessment information to evaluate potential public health risk associated with environmental contaminants.

  19. Comments on potential geologic and seismic hazards affecting Mare Island, Solano County, California

    USGS Publications Warehouse

    Holzer, T.L.; Wentworth, C.M.; Bakun, W.H.; Boatwright, J.; Brocher, T.E.; Çelebi, M.; Ellsworth, W.L.; Fletcher, J.P.B.; Geist, E.L.; Graymer, R.W.; Kayen, R.E.; Keefer, D.K.; Oppenheimer, D.H.; Savage, W.U.; Schwartz, D.P.; Simpson, R.W.

    2002-01-01

    This report was prepared in response to a written request from the City of Vallejo, California, to the U.S. Geological Survey (USGS). By letter of October 4, 2002, the City requested that the USGS "provide advice to the City’s LNG Health and Safety Committee on its review of a potential liquid natural gas project" on the southern portion of Mare Island. The City specifically requested that the USGS advise the committee on potential hazards including fault rupture, earthquake ground motion, soil failure during earthquakes, tsunami and seiche, and landslides. The City requested that the USGS: (1) comment on these hazards, (2) describe its degree of confidence in its opinions, and (3) describe the scope of additional studies that will be needed if the City enters into an agreement with project sponsors. Advice was also requested on the selection of the safe shutdown and operating basis earthquakes as specified in the NFPA 59A standard (NFPA, 2001). This review of published reports and other publicly available information indicates that all of the hazards on which the USGS was asked to comment should be considered for the proposed project on the southern portion of Mare Island. Available information differs greatly for each of these potential hazards, and adequate understanding for design will require detailed site-specific investigations.

  20. Characterization and validation of an in silico toxicology model to predict the mutagenic potential of drug impurities*

    SciTech Connect

    Valerio, Luis G.; Cross, Kevin P.

    2012-05-01

    Control and minimization of human exposure to potential genotoxic impurities found in drug substances and products is an important part of preclinical safety assessments of new drug products. The FDA's 2008 draft guidance on genotoxic and carcinogenic impurities in drug substances and products allows use of computational quantitative structure–activity relationships (QSAR) to identify structural alerts for known and expected impurities present at levels below qualified thresholds. This study provides the information necessary to establish the practical use of a new in silico toxicology model for predicting Salmonella t. mutagenicity (Ames assay outcome) of drug impurities and other chemicals. We describe the model's chemical content and toxicity fingerprint in terms of compound space, molecular and structural toxicophores, and have rigorously tested its predictive power using both cross-validation and external validation experiments, as well as case studies. Consistent with desired regulatory use, the model performs with high sensitivity (81%) and high negative predictivity (81%) based on external validation with 2368 compounds foreign to the model and having known mutagenicity. A database of drug impurities was created from proprietary FDA submissions and the public literature which found significant overlap between the structural features of drug impurities and training set chemicals in the QSAR model. Overall, the model's predictive performance was found to be acceptable for screening drug impurities for Salmonella mutagenicity. -- Highlights: ► We characterize a new in silico model to predict mutagenicity of drug impurities. ► The model predicts Salmonella mutagenicity and will be useful for safety assessment. ► We examine toxicity fingerprints and toxicophores of this Ames assay model. ► We compare these attributes to those found in drug impurities known to FDA/CDER. ► We validate the model and find it has a desired predictive performance.

  1. Potential hazards from floodflows in Wildrose Canyon, Death Valley National Monument, California-Nevada

    USGS Publications Warehouse

    Crippen, John R.

    1981-01-01

    Wildrose Canyon, in the western slopes of the Panamint Mountains , is a well-traveled route in Death Valley National Monument and is a scenic area often visited for its own sake. It is an arid region that is subject to flash flooding. Although such flooding is infrequent, when it occurs in the steep, narrow canyon within which the road lies, the flow of water and accompanying debris may be hazardous to life and to any obstacle in its path. Historical records of amounts of rainfall and floodflow in the area are sparse, but data from the basin and from similar areas in the desert mountains of southern California are sufficient to provide a basis for estimates of the degree of hazard. Potential hazards from floodflows are defined for Wildrose Canyon and its nearby approach routes. (USGS)

  2. Screening for potential endocrine disruptors in fish: evidence from structural alerts and in vitro and in vivo toxicological assays.

    PubMed

    Nendza, Monika; Wenzel, Andrea; Müller, Martin; Lewin, Geertje; Simetska, Nelly; Stock, Frauke; Arning, Jürgen

    2016-01-01

    better for substances with (very) high estrogenic and androgenic activities, there is reasonable probability that the most hazardous candidates have been identified. The combination of structural alerts, in vitro receptor-based assays, and in vivo mammalian studies may support the priority setting for further assessments of chemicals with potential environmental hazards due to estrogenic and androgenic activities.

  3. A new approach to spatial identification of potential health hazards associated with childhood asthma.

    PubMed

    Svechkina, Alina; Portnov, Boris A

    2017-10-01

    Childhood asthma is a chronic disease, known to be linked to prolonged exposure to air pollution. However, the identification of specific health hazards, associated with childhood asthma is not always straightforward, due to the presence of multiple sources of air pollution in urban areas. In this study, we test a novel approach to the spatial identification of environmental hazards that have the highest probability of association with the observed asthma morbidity patterns. The effect of a particular health hazard on population morbidity is expected to weaken with distance. To account for this effect, we rank potential health hazards based on the strength of association between the observed morbidity patterns and wind-direction weighted proximities to these locations. We validate this approach by applying it to a study of spatial patterns of childhood asthma in the Greater Haifa Metropolitan Area (GHMA) in Israel, characterised by multiple health hazards. We identified a spot in the local industrial zone as the primary risk source for the observed asthma morbidity patterns. Multivariate regressions, controlling for socio-economic and geographic variables, revealed that the observed incidence rates of asthma tend to decline as a function of distance from the identified industrial location. The proposed identification approach uses disease patterns as its main input, and can be used by researches as a preliminary risk assessment tool, in cases in which specific sources of locally elevated morbidity are unclear or cannot be identified by traditional methods. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. A strategic assessment of crown fire hazard in Montana: potential effectiveness and costs of hazard reduction treatments.

    Treesearch

    Carl E. Fiedler; Charles E. Keegan; Christopher W. Woodall; Todd A. Morgan

    2004-01-01

    Estimates of crown fire hazard are presented for existing forest conditions in Montana by density class, structural class, forest type, and landownership. Three hazard reduction treatments were evaluated for their effectiveness in treating historically fire-adapted forests (ponderosa pine (Pinus ponderosa Dougl. ex Laws.), Douglas-fir (...

  5. Newspaper reports from the Coroners Court in Ireland are used to reveal the potential complexity and need for reform in forensic toxicology and medicine services.

    PubMed

    Tormey, William P

    2015-05-01

    Newspapers devote regular space to inquests in the public interest. Accuracy in determining the causes of death is important for public health. Expert opinion features prominently in press reports and is an important channel of public education. How expert are the experts and how complex are apparently simple cases? Toxicology cases involving cannabis and stroke, 'junk food' diet, unexplained sudden death, potential drug interactions, allergy during caesarean section, and ecstacy-type drugs are used to illustrate the complexities. A template for reform is suggested to reform the Coroners Laws in Ireland to recognise the complexity of forensic toxicology and medicine. Copyright © 2015 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  6. Radiological/toxicological sabotage assessments at the Savannah River Site

    SciTech Connect

    Johnson, H.D.; Pascal, M.D.; Richardson, D.L.

    1995-11-01

    This paper describes the methods being employed by Westinghouse Savannah River Company (WSRC) to perform graded assessments of radiological and toxicological sabotage vulnerability at Savannah River Site (SRS) facilities. These assessments are conducted to ensure that effective measures are in place to prevent, mitigate, and respond to a potential sabotage event which may cause an airborne release of radiological/toxicological material, causing an adverse effect on the health and safety of employees, the public, and the environment. Department of Energy (DOE) Notice 5630.3A, {open_quotes}Protection of Departmental Facilities Against Radiological and Toxicological Sabotage,{close_quotes} and the associated April 1993 DOE-Headquarters guidance provide the requirements and outline an eight-step process for hazardous material evaluation. The process requires the integration of information from a variety of disciplines, including safety, safeguards and security, and emergency preparedness. This paper summarizes WSRC`s approach towards implementation of the DOE requirements, and explains the inter-relationships between the Radiological and Toxicological Assessments developed using this process, and facility Hazard Assessment Reports (HAs), Safety Analysis Reports (SARs), and Facility Vulnerability Assessments (VAs).

  7. Toxicological features of maleilated polyflavonoids from Pinus radiata (D. Don.) as potential functional additives for biomaterials design.

    PubMed

    García, Danny E; Medina, Paulina A; Zúñiga, Valentina I

    2017-03-14

    Polyflavonoids from Pinus radiata (D. Don.) are an abundant natural oligomers highly desirable as renewable chemicals. However, structural modification of polyflavonoids is a viable strategy in order to use such polyphenols as macrobuilding-blocks for biomaterial design. Polyflavonoids were esterified with three five-member cyclic anhydrides (maleic, itaconic, and citraconic) at 20 °C during 24 h in order to diversify physicochemical-, and biological-properties for agricultural, and food-packaging applications. In addition, the influence of the chemical modification, as well as the chemical structure of the grafting on toxicological features was evaluated. Structural features of derivatives were analyzed by spectroscopy (FT-IR and (1)H-NMR), and the degree of substitution was calculated. Toxicological profile was assessed by using three target species in a wide range of concentration (0.01-100 mgL(-)(1)). Effect of polyflavonoids on the growth rate (Selenastrum capricornutum), mortality (Daphnia magna), and germination and radicle length (Lactuca sativa) was determined. Chemical modification affects the toxicological profile on the derivatives in a high extent. Results described remarkable differences in function of the target specie. The bioassays indicate differences of the polyflavonoids toxicological profile associated to the chemical structure of the grafting. Results allowed conclude that polyflavonoids from pine bark show slight toxic properties.

  8. Potential environmental impacts of light-emitting diodes (LEDs): metallic resources, toxicity, and hazardous waste classification.

    PubMed

    Lim, Seong-Rin; Kang, Daniel; Ogunseitan, Oladele A; Schoenung, Julie M

    2011-01-01

    Light-emitting diodes (LEDs) are advertised as environmentally friendly because they are energy efficient and mercury-free. This study aimed to determine if LEDs engender other forms of environmental and human health impacts, and to characterize variation across different LEDs based on color and intensity. The objectives are as follows: (i) to use standardized leachability tests to examine whether LEDs are to be categorized as hazardous waste under existing United States federal and California state regulations; and (ii) to use material life cycle impact and hazard assessment methods to evaluate resource depletion and toxicity potentials of LEDs based on their metallic constituents. According to federal standards, LEDs are not hazardous except for low-intensity red LEDs, which leached Pb at levels exceeding regulatory limits (186 mg/L; regulatory limit: 5). However, according to California regulations, excessive levels of copper (up to 3892 mg/kg; limit: 2500), Pb (up to 8103 mg/kg; limit: 1000), nickel (up to 4797 mg/kg; limit: 2000), or silver (up to 721 mg/kg; limit: 500) render all except low-intensity yellow LEDs hazardous. The environmental burden associated with resource depletion potentials derives primarily from gold and silver, whereas the burden from toxicity potentials is associated primarily with arsenic, copper, nickel, lead, iron, and silver. Establishing benchmark levels of these substances can help manufacturers implement design for environment through informed materials substitution, can motivate recyclers and waste management teams to recognize resource value and occupational hazards, and can inform policymakers who establish waste management policies for LEDs.

  9. Toxicological benchmarks for screening potential contaminants of concern for effects on soil and litter invertebrates and heterotrophic process

    SciTech Connect

    Will, M.E.; Suter, G.W. II

    1994-09-01

    One of the initial stages in ecological risk assessments for hazardous waste sites is the screening of contaminants to determine which of them are worthy of further consideration as {open_quotes}contaminants of potential concern.{close_quotes} This process is termed {open_quotes}contaminant screening.{close_quotes} It is performed by comparing measured ambient concentrations of chemicals to benchmark concentrations. Currently, no standard benchmark concentrations exist for assessing contaminants in soil with respect to their toxicity to soil- and litter-dwelling invertebrates, including earthworms, other micro- and macroinvertebrates, or heterotrophic bacteria and fungi. This report presents a standard method for deriving benchmarks for this purpose, sets of data concerning effects of chemicals in soil on invertebrates and soil microbial processes, and benchmarks for chemicals potentially associated with United States Department of Energy sites. In addition, literature describing the experiments from which data were drawn for benchmark derivation. Chemicals that are found in soil at concentrations exceeding both the benchmarks and the background concentration for the soil type should be considered contaminants of potential concern.

  10. Potential hazards associated with combustion of bio-derived versus petroleum-derived diesel fuel.

    PubMed

    Bünger, Jürgen; Krahl, Jürgen; Schröder, Olaf; Schmidt, Lasse; Westphal, Götz A

    2012-10-01

    Fuels from renewable resources have gained worldwide interest due to limited fossil oil sources and the possible reduction of atmospheric greenhouse gas. One of these fuels is so called biodiesel produced from vegetable oil by transesterification into fatty acid methyl esters (FAME). To get a first insight into changes of health hazards from diesel engine emissions (DEE) by use of biodiesel scientific studies were reviewed which compared the combustion of FAME with common diesel fuel (DF) for legally regulated and non-regulated emissions as well as for toxic effects. A total number of 62 publications on chemical analyses of DEE and 18 toxicological in vitro studies were identified meeting the criteria. In addition, a very small number of human studies and animal experiments were available. In most studies, combustion of biodiesel reduces legally regulated emissions of carbon monoxide, hydrocarbons, and particulate matter. Nitrogen oxides are regularly increased. Among the non-regulated emissions aldehydes are increased, while polycyclic aromatic hydrocarbons are lowered. Most biological in vitro assays show a stronger cytotoxicity of biodiesel exhaust and the animal experiments reveal stronger irritant effects. Both findings are possibly caused by the higher content of nitrogen oxides and aldehydes in biodiesel exhaust. The lower content of PAH is reflected by a weaker mutagenicity compared to DF exhaust. However, recent studies show a very low mutagenicity of DF exhaust as well, probably caused by elimination of sulfur in present DF qualities and the use of new technology diesel engines. Combustion of vegetable oil (VO) in common diesel engines causes a strongly enhanced mutagenicity of the exhaust despite nearly unchanged regulated emissions. The newly developed fuel "hydrotreated vegetable oil" (HVO) seems to be promising. HVO has physical and chemical advantages compared to FAME. Preliminary results show lower regulated and non-regulated emissions and a

  11. Potential hazards associated with combustion of bio-derived versus petroleum-derived diesel fuel

    PubMed Central

    Bünger, Jürgen; Krahl, Jürgen; Schröder, Olaf; Schmidt, Lasse; Westphal, Götz A.

    2012-01-01

    Fuels from renewable resources have gained worldwide interest due to limited fossil oil sources and the possible reduction of atmospheric greenhouse gas. One of these fuels is so called biodiesel produced from vegetable oil by transesterification into fatty acid methyl esters (FAME). To get a first insight into changes of health hazards from diesel engine emissions (DEE) by use of biodiesel scientific studies were reviewed which compared the combustion of FAME with common diesel fuel (DF) for legally regulated and non-regulated emissions as well as for toxic effects. A total number of 62 publications on chemical analyses of DEE and 18 toxicological in vitro studies were identified meeting the criteria. In addition, a very small number of human studies and animal experiments were available. In most studies, combustion of biodiesel reduces legally regulated emissions of carbon monoxide, hydrocarbons, and particulate matter. Nitrogen oxides are regularly increased. Among the non-regulated emissions aldehydes are increased, while polycyclic aromatic hydrocarbons are lowered. Most biological in vitro assays show a stronger cytotoxicity of biodiesel exhaust and the animal experiments reveal stronger irritant effects. Both findings are possibly caused by the higher content of nitrogen oxides and aldehydes in biodiesel exhaust. The lower content of PAH is reflected by a weaker mutagenicity compared to DF exhaust. However, recent studies show a very low mutagenicity of DF exhaust as well, probably caused by elimination of sulfur in present DF qualities and the use of new technology diesel engines. Combustion of vegetable oil (VO) in common diesel engines causes a strongly enhanced mutagenicity of the exhaust despite nearly unchanged regulated emissions. The newly developed fuel “hydrotreated vegetable oil” (HVO) seems to be promising. HVO has physical and chemical advantages compared to FAME. Preliminary results show lower regulated and non-regulated emissions and a

  12. The Potentially Hazardous Asteroid 2007 PA8: a fresh L chondrite analogue

    NASA Astrophysics Data System (ADS)

    Fornasier, S.; Belskaya, I.; Perna, D.

    2014-04-01

    We present in this work the results on the polarimetric and spectroscopic observations of the Potentially Hazardous Asteroid (PHA) 2007 PA8 obtained during its favourable apparition of October-November 2012, when it approached the Earth at the minimal distance of 0.043 AU. Our data allow to constrain the surface composition of this PHA, to obtain the first estimation of its albedo and to determine its size.

  13. The reduction of a ""safety catastrophic'' potential hazard: A case history

    NASA Technical Reports Server (NTRS)

    Jones, J. P.

    1971-01-01

    A worst case analysis is reported on the safety of time watch movements for triggering explosive packages on the lunar surface in an experiment to investigate physical lunar structural characteristics through induced seismic energy waves. Considered are the combined effects of low pressure, low temperature, lunar gravity, gear train error, and position. Control measures constitute a seal control cavity and design requirements to prevent overbanking in the mainspring torque curve. Thus, the potential hazard is reduced to safety negligible.

  14. Experimental investigation to evaluate the potential environmental hazards of photovoltaic panels.

    PubMed

    Tammaro, Marco; Salluzzo, Antonio; Rimauro, Juri; Schiavo, Simona; Manzo, Sonia

    2016-04-05

    Recently the potential environmental hazard of photovoltaic modules together with their management as waste has attracted the attention of scientists. Particular concern is aroused by the several metals contained in photovoltaic panels whose potential release in the environment were scarcely investigated. Here, for the first time, the potential environmental hazard of panels produced in the last 30 years was investigated through the assessment of up to 18 releasable metals. Besides, the corresponding ecotoxicological effects were also evaluated. Experimental data were compared with the current European and Italian law limits for drinking water, discharge on soil and landfill inert disposal in order to understand the actual pollution load. Results showed that less than 3% of the samples respected all law limits and around 21% was not ecotoxic. By considering the technological evolutions in manufacturing, we have shown that during the years crystalline silicon panels have lower tendency to release hazardous metals with respect to thin film panels. In addition, a prediction of the amounts of lead, chromium, cadmium and nickel releasable from next photovoltaic waste was performed. The prevision up to 2050 showed high amounts of lead (30t) and cadmium (2.9t) releasable from crystalline and thin film panels respectively.

  15. The potential of an earthworm avoidance test for evaluation of hazardous waste sites

    SciTech Connect

    Yeardley, R.B. Jr.; Gast, L.C.; Lazorchak, J.M.

    1996-09-01

    An earthworm avoidance test has potential advantages for use in evaluation of hazardous wastes sites. Because organisms often exhibit behavioral responses at lower levels of stress than those that acute toxicity tests are able to detect, avoidance tests could provide increased sensitivity to hazardous chemicals. Avoidance is an ecologically relevant endpoint that neither acute nor sublethal tests measure. Avoidance can potentially indicate sublethal stress in a short period of time, testing is easily done in a soil matrix, and an avoidance test has the potential for specialized applications for soil testing. Dual-control test data established that, in absence of a toxicant, worms did not congregate, but instead distributed themselves fairly randomly with respect to the two sides of the test chambers, that is, they did not display behavior that might be mistaken for avoidance. In tests with artificial soil spiked with reference toxicants and hazardous site soils, worms avoided soils containing various toxic chemicals. Avoidance behavior proved in most cases be a more sensitive indicator of chemical contamination than acute tests. Determination of avoidance was possible in 1 to 2 d, much less than the current duration of acute and sublethal earthworm tests.

  16. Predictive Models and Computational Toxicology

    EPA Science Inventory

    Understanding the potential health risks posed by environmental chemicals is a significant challenge elevated by the large number of diverse chemicals with generally uncharacterized exposures, mechanisms, and toxicities. The ToxCast computational toxicology research program was l...

  17. Predictive Models and Computational Toxicology

    EPA Science Inventory

    Understanding the potential health risks posed by environmental chemicals is a significant challenge elevated by the large number of diverse chemicals with generally uncharacterized exposures, mechanisms, and toxicities. The ToxCast computational toxicology research program was l...

  18. Fuzzy Cognitive Maps for Glacier Hazards Assessment: Application to Predicting the Potential for Glacier Lake Outbursts

    NASA Astrophysics Data System (ADS)

    Furfaro, R.; Kargel, J. S.; Fink, W.; Bishop, M. P.

    2010-12-01

    Glaciers and ice sheets are among the largest unstable parts of the solid Earth. Generally, glaciers are devoid of resources (other than water), are dangerous, are unstable and no infrastructure is normally built directly on their surfaces. Areas down valley from large alpine glaciers are also commonly unstable due to landslide potential of moraines, debris flows, snow avalanches, outburst floods from glacier lakes, and other dynamical alpine processes; yet there exists much development and human occupation of some disaster-prone areas. Satellite remote sensing can be extremely effective in providing cost-effective and time- critical information. Space-based imagery can be used to monitor glacier outlines and their lakes, including processes such as iceberg calving and debris accumulation, as well as changing thicknesses and flow speeds. Such images can also be used to make preliminary identifications of specific hazardous spots and allows preliminary assessment of possible modes of future disaster occurrence. Autonomous assessment of glacier conditions and their potential for hazards would present a major advance and permit systematized analysis of more data than humans can assess. This technical leap will require the design and implementation of Artificial Intelligence (AI) algorithms specifically designed to mimic glacier experts’ reasoning. Here, we introduce the theory of Fuzzy Cognitive Maps (FCM) as an AI tool for predicting and assessing natural hazards in alpine glacier environments. FCM techniques are employed to represent expert knowledge of glaciers physical processes. A cognitive model embedded in a fuzzy logic framework is constructed via the synergistic interaction between glaciologists and AI experts. To verify the effectiveness of the proposed AI methodology as applied to predicting hazards in glacier environments, we designed and implemented a FCM that addresses the challenging problem of autonomously assessing the Glacier Lake Outburst Flow

  19. The Pedestrian Evacuation Analyst: geographic information systems software for modeling hazard evacuation potential

    USGS Publications Warehouse

    Jones, Jeanne M.; Ng, Peter; Wood, Nathan J.

    2014-01-01

    Recent disasters such as the 2011 Tohoku, Japan, earthquake and tsunami; the 2013 Colorado floods; and the 2014 Oso, Washington, mudslide have raised awareness of catastrophic, sudden-onset hazards that arrive within minutes of the events that trigger them, such as local earthquakes or landslides. Due to the limited amount of time between generation and arrival of sudden-onset hazards, evacuations are typically self-initiated, on foot, and across the landscape (Wood and Schmidtlein, 2012). Although evacuation to naturally occurring high ground may be feasible in some vulnerable communities, evacuation modeling has demonstrated that other communities may require vertical-evacuation structures within a hazard zone, such as berms or buildings, if at-risk individuals are to survive some types of sudden-onset hazards (Wood and Schmidtlein, 2013). Researchers use both static least-cost-distance (LCD) and dynamic agent-based models to assess the pedestrian evacuation potential of vulnerable communities. Although both types of models help to understand the evacuation landscape, LCD models provide a more general overview that is independent of population distributions, which may be difficult to quantify given the dynamic spatial and temporal nature of populations (Wood and Schmidtlein, 2012). Recent LCD efforts related to local tsunami threats have focused on an anisotropic (directionally dependent) path distance modeling approach that incorporates travel directionality, multiple travel speed assumptions, and cost surfaces that reflect variations in slope and land cover (Wood and Schmidtlein, 2012, 2013). The Pedestrian Evacuation Analyst software implements this anisotropic path-distance approach for pedestrian evacuation from sudden-onset hazards, with a particular focus at this time on local tsunami threats. The model estimates evacuation potential based on elevation, direction of movement, land cover, and travel speed and creates a map showing travel times to safety (a

  20. Fiber contamination of vermiculites: a potential occupational and environmental health hazard

    SciTech Connect

    Moatamed, F.; Lockey, J.E.; Parry, W.T.

    1986-10-01

    Vermiculite ores from Montana, Virginia, and South Africa have been analyzed for the presence of amphibole contamination. Fibrous actinolite was found in unexpanded Montana vermiculite ore at a maximum concentration of 0.2%. The fibers persisted in the expanded ore at a maximum concentration of 0.6%. Actinolite was also found in the Virginia vermiculite ore but at a lower concentration and mostly as cleavage fragments with low length-to-width ratios. South African ore contained rare anthophyllite fibers also with low length-to-width ratios. Vermiculite ores have the potential for amphibole contamination and can represent potential health hazards without proper occupational and environmental control measures.

  1. Fiber contamination of vermiculites: a potential occupational and environmental health hazard.

    PubMed

    Moatamed, F; Lockey, J E; Parry, W T

    1986-10-01

    Vermiculite ores from Montana, Virginia, and South Africa have been analyzed for the presence of amphibole contamination. Fibrous actinolite was found in unexpanded Montana vermiculite ore at a maximum concentration of 2.0%. The fibers persisted in the expanded ore at a maximum concentration of 0.6%. Actinolite was also found in the Virginia vermiculite ore but at a lower concentration and mostly as cleavage fragments with low length-to-width ratios. South African ore contained rare anthophyllite fibers also with low length-to-width ratios. Vermiculite ores have the potential for amphibole contamination and can represent potential health hazards without proper occupational and environmental control measures.

  2. Analysis of potential hazards associated with 241Am loaded resins from nitrate media

    SciTech Connect

    Schulte, Louis D.; Rubin, Jim; Fife, Keith William; Ricketts, Thomas Edgar; Tappan, Bryce C.; Chavez, David E.

    2016-02-19

    LANL has been contacted to provide possible assistance in safe disposition of a number of 241Am-bearing materials associated with local industrial operations. Among the materials are ion exchange resins which have been in contact with 241Am and nitric acid, and which might have potential for exothermic reaction. The purpose of this paper is to analyze and define the resin forms and quantities to the extent possible from available data to allow better bounding of the potential reactivity hazard of the resin materials. An additional purpose is to recommend handling procedures to minimize the probability of an uncontrolled exothermic reaction.

  3. Persistence in earthworms and potential hazards to birds of soil applied DDT, dieldrin, and heptachlor

    USGS Publications Warehouse

    Beyer, W.N.; Gish, C.D.

    1980-01-01

    (1) DDT, dieldrin, and heptachlor were each applied to separate replicate plots in a hay field at 0.6, 2.2, or 9.0 kg/ha. For 11 yr thereafter, soil and earthworms were analysed for residues. (2) The average ratios of residues in earthworms (dry weight) to residues in soil (dry weight) were: total DDT, 5; dieldrin, 8; and heptachlor epoxide, 10. The average time for the initial residues in soil to be reduced by 50% were: total DDT, 3.2 yr; dieldrin, 5.1 yr; and heptachlor epoxide, 3.2 yr. The corresponding times for residues in earthworms were: total DDT, 3.2 yr; dieldrin, 2.6 yr; and heptachlor epoxide, 3.0 yr. (3) DDE was most persistent, and in plots treated at 9.0 kg/ha its concentration remained constant at about 0.4 ppm in soil and about 7 ppm in earthworms. (4) When applied at 9.0 kg/ha, DDT accumulated in earthworms to concentrations (32 ppm) which laboratory studies have shown to be hazardous to some sensitive bird species. When heptachlor was applied at 2.2 or 9.0 kg/ha, heptachlor epoxide in earthworms reached concentrations (8 ppm) potentially hazardous to woodcock. Dieldrin remained at potentially hazardous concentrations (8 ppm) for 3 yr in plots treated with 2.2 kg/ha and for 11 yr in plots treated with 9.0 kg/ha.

  4. IRIS Toxicological Review and Summary Documents for ...

    EPA Pesticide Factsheets

    Carbon tetrachloride is a volatile haloalkane with a wide range of industrial and chemical applications. It is produced commercially from chlorination of a variety of low molecular weight hydrocarbons such as carbon disulfide, methanol, methane, propane, and ethylene dichloride. It is also produced by thermal chlorination in the production of tetrachloroethylene. Major uses of carbon tetrachloride have been in the recovery of tin from tin plating waste, in formulation of petrol additives and refrigerants, in metal degreasing and agricultural fumigants, in chlorination of organic compounds, in the production of semiconductors, in the reduction of fire hazard, as a solvent for rubber cement, and as a catalyst in polymer technology. Its production has been decreasing and it is no longer permitted in products intended for home use. Despite this ban, carbon tetrachloride has been detected at 314 hazardous waste sites. EPA's assessment of noncancer health effects and carcinogenic potential of carbon tetrachloride was last prepared and added to the IRIS database in 1991. The IRIS program is preparing an assessment that will incorporate health effects information available for carbon tetrachloride, and current risk assessment methods. The IRIS assessment for carbon tetrachloride will consist of a Toxicological Review and IRIS Summary. The Toxicological Review is a critical review of the physiochemical and toxicokinetic properties of a chemical, and its toxicity

  5. The Toxicology Education Summit: Building the Future of Toxicology Through Education

    PubMed Central

    Barchowsky, Aaron; Buckley, Lorrene A.; Carlson, Gary P.; Fitsanakis, Vanessa A.; Ford, Sue M.; Genter, Mary Beth; Germolec, Dori R.; Leavens, Teresa L.; Lehman-McKeeman, Lois D.; Safe, Stephen H.; Sulentic, Courtney E. W.; Eidemiller, Betty J.

    2012-01-01

    Toxicology and careers in toxicology, as well as many other scientific disciplines, are undergoing rapid and dramatic changes as new discoveries, technologies, and hazards advance at a blinding rate. There are new and ever increasing demands on toxicologists to keep pace with expanding global economies, highly fluid policy debates, and increasingly complex global threats to public health. These demands must be met with new paradigms for multidisciplinary, technologically complex, and collaborative approaches that require advanced and continuing education in toxicology and associated disciplines. This requires paradigm shifts in educational programs that support recruitment, development, and training of the modern toxicologist, as well as continued education and retraining of the midcareer professional to keep pace and sustain careers in industry, government, and academia. The Society of Toxicology convened the Toxicology Educational Summit to discuss the state of toxicology education and to strategically address educational needs and the sustained advancement of toxicology as a profession. The Summit focused on core issues of: building for the future of toxicology through educational programs; defining education and training needs; developing the “Total Toxicologist”; continued training and retraining toxicologists to sustain their careers; and, finally, supporting toxicology education and professional development. This report summarizes the outcomes of the Summit, presents examples of successful programs that advance toxicology education, and concludes with strategies that will insure the future of toxicology through advanced educational initiatives. PMID:22461448

  6. The potential toxicological insights about the anti-HIV drug azidothymidine-derived monoselenides in human leukocytes: Toxicological insights of new selenium-azidothymidine analogs.

    PubMed

    Mariano, Doc; de Souza, D; Meinerz, D F; Allebrandt, J; de Bem, A F; Hassan, W; Rodrigues, Oed; da Rocha, Jbt

    2017-09-01

    Acquired immunodeficiency syndrome (AIDS) is a worldwide disease characterized by impairments of immune function. AIDS can be associated with oxidative stress (OS) that can be linked to selenium (Se) deficiency. Se is fundamental for the synthesis of selenoproteins, such as glutathione peroxidase and thioredoxin reductase. These enzymes catalyze the decomposition of reactive oxygen species and contribute to maintain equilibrium in cell redox status. Literature data indicate that organoselenium compounds, such as ebselen and diphenyl diselenide, have antioxidant properties in vitro and in vivo models associated with OS. Nevertheless, selenocompounds can also react and oxidize thiols groups, inducing toxicity in mammals. Here, we tested the potential cytotoxic and genotoxic properties of six analogs of the prototypal anti-HIV drug azidothymidine (AZT) containing Se (5'-Se-(phenyl)zidovudine; 5'-Se-(1,3,5-trimethylphenyl)zidovudine; 5'-Se-(1-naphtyl)zidovudine; 5'-Se-(4-chlorophenyl)zidovudine) (C4); 5'-Se-(4-methylphenyl)zidovudine (C5); and 5'-(4-methylbenzoselenoate)zidovudine). C5 increased the rate of dithiothreitol oxidation (thiol oxidase activity) and C2-C4 and C6 (at 100 µM) increased DNA damage index (DI) in human leukocytes. Moreover, C5 (200 µM) decreased human leukocyte viability to about 50%. Taken together, these results indicated the low in vitro toxicity in human leukocytes of some Se-containing analogs of AZT.

  7. IRIS Toxicological Review of Dichloromethane (Methylene ...

    EPA Pesticide Factsheets

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of Dichloromethane that when finalized will appear on the Integrated Risk Information System (IRIS) database. The draft Toxicological Review of Dichloromethane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to dichloromethane.

  8. Microbiological quality of seasoned roasted laver and potential hazard control in a real processing line.

    PubMed

    Choi, Eun Sook; Kim, Nam Hee; Kim, Hye Won; Kim, Sun Ae; Jo, Jun Il; Kim, Soon Han; Lee, Soon Ho; Ha, Sang Do; Rhee, Min Suk

    2014-12-01

    Microbiological quality of laver, one of the edible seaweeds, has not been reported in a real processing line. Laver or supplements were collected from six manufacturers (A to F) to assess potential microbiological hazards and the critical control points in commercial processing lines. Aerobic plate counts (APC), coliform counts, Bacillus cereus, Staphylococcus aureus, and Vibrio parahaemolyticus were enumerated, and the presence of B. cereus, Listeria monocytogenes, Salmonella, S. aureus, and V. parahaemolyticus were confirmed during processing. The raw material, i.e., dried laver, had a high initial APC level (4.4 to 7.8 log CFU/g), which decreased gradually during processing (final products, 1.3 to 5.9 log CFU/g). Coliforms and B. cereus were not detected in any of the final products, but they were present in some raw materials and semiprocessed products in quantitative analysis. After enrichment for recovery of stress-injured cells, E. coli and foodborne pathogens were not detected in any samples, with the exception of B. cereus. Heat-injured and spore-forming B. cereus isolates were occasionally obtained from some of the raw materials and products after enrichment, thus B. cereus may be a potential microbiological hazard that should be controlled using strategic intervention measures. Secondary roasting (260 to 400°C, 2 to 10 s) significantly reduced the APC (maximum log reduction, 4.7 log CFU/g), and this could be a key intervention step for controlling microbiological hazards during processing (critical control point). When this step was performed appropriately, according to the processing guide for each plant, the microorganisms were inactivated more successfully in the products. This study provides scientific evidence that may facilitate the development of strategies for microbiological hazard control and hygienic management guidelines for real manufacturing plants.

  9. IRIS Toxicological Review of Ammonia Noncancer Inhalation ...

    EPA Pesticide Factsheets

    EPA has finalized the Integrated Risk Information System (IRIS) Assessment of Ammonia (Noncancer Inhalation). This assessment addresses the potential noncancer human health effects from long-term inhalation exposure to ammonia. Now final, this assessment will update the current toxicological information on ammonia posted in 1991. EPA’s program and regional offices may use this assessment to inform decisions to protect human health. EPA completed the Integrated Risk Information System (IRIS) health assessment for ammonia. IRIS is an EPA database containing Agency scientific positions on potential adverse human health effects that may result from chronic (or lifetime) exposure to chemicals in the environment. IRIS contains chemical-specific summaries of qualitative and quantitative health information in support of two steps of the risk assessment paradigm, i.e., hazard identification and dose-response evaluation. IRIS assessments are used in combination with specific situational exposure assessment information to evaluate potential public health risk associated with environmental contaminants.

  10. Tropical cyclone potential hazard in Southeast China and its linkage with the East Asian westerly jet

    NASA Astrophysics Data System (ADS)

    Yu, Jin-hua; Xue, Hua-xing; Song, Jie

    2017-05-01

    A new synthesized index for estimating the hazard of both accumulated strong winds and heavy rainfall from a tropical cyclone (TC) is presented and applied to represent TC potential hazard over Southeast China. Its relationship with the East Asian westerly jet in the upper troposphere is also investigated. The results show that the new TC potential hazard index (PHI) is good at reflecting individual TC hazard and has significantly higher correlation with economic losses. Seasonal variation of TC-PHI shows that the largest TC-PHI on average occurs in July-August, the months when most TCs make landfall over mainland China. The spatial distribution of PHI at site shows that high PHI associated with major landfall TCs occurs along the southeast coast of China. An East Asian westerly jet index (EAWJI), which represents the meridional migration of the westerly jet, is defined based on two regions where significant correlations exist between TC landfall frequency and zonal wind at 200 hPa. Further analyses show that an anomalous easterly steering flow occurred above the tracks of TCs, and favored TCs making landfall along the southeast coast of China, leading to an increase in the landfall TC when the EAWJ was located north of its average latitude. Meanwhile, anomalous easterly wind shear and positive anomaly in low-level relative vorticity along TCs landfall-track favored TC development. In addition, anomalous water vapor transport from westerly wind in the South China Sea resulted in more condensational heating and an enhanced monsoon trough, leading to the maintenance of TC intensity for a longer time. All of these environmental factors increase the TC potential hazard in Southeast China. Furthermore, the EAWJ may affect tropical circulation by exciting meridional propagation of transient eddies. During a low EAWJI phase in July-August, anomalous transient eddy vorticity flux at 200 hPa propagates southward over the exit region of the EAWJ, resulting in eddy vorticity

  11. IRIS Toxicological Review and Summary Documents for Chloroethane (Peer Review Plan)

    EPA Science Inventory

    Toxicological data in the published literature on Chloroethane (CE) will be assimilated, reviewed, and integated into a Toxicological Review of CE (assessment document), which seeks to characterize the key cancer, and non cancer health effect hazards from environmental exposures...

  12. IRIS Toxicological Review and Summary Documents for Chloroethane (Peer Review Plan)

    EPA Science Inventory

    Toxicological data in the published literature on Chloroethane (CE) will be assimilated, reviewed, and integated into a Toxicological Review of CE (assessment document), which seeks to characterize the key cancer, and non cancer health effect hazards from environmental exposures...

  13. Volcano hazards and potential risks on St. Paul Island, Pribilof Islands, Bering Sea, Alaska

    NASA Astrophysics Data System (ADS)

    Feeley, T. C.; Winer, G. S.

    2009-05-01

    Volcano hazards and potential risks on St. Paul Island, Alaska, are assessed on the basis of the recent volcanic history of the island. The long-term frequency of volcanic eruptions is estimated using a count of 40 identifiable vents considered to represent separate eruptions. Assuming regular temporal spacing of these events during the period 360,000 to 3230 y.b.p., the estimated mean recurrence time is 0.11 × 10 - 3 eruption/year and the eruptive interval is approximately 8900 years. Volcano hazards on St. Paul are associated exclusively with the eruption of low viscosity alkali basaltic magma. The most important are lava flows, tephra fallout, and base surges. Other hazards include volcanic gases, seismicity and ground deformation associated with dike intrusion beneath rift zones, and explosive lava-water interactions along coastal regions and water-saturated ground. The general characteristics of past volcanism on St. Paul indicate that the most likely styles of future eruptions will be (1) Hawaiian-style eruptions with fire fountains and pahoehoe lava flows issuing from one of two polygenetic shield volcanoes on the island; (2) Strombolian-style, scoria cone-building eruptions with associated tephra fallout and eruption of short pahoehoe lava flows; and (3) explosive Surtseyan-style, phreatomagmatic eruptions initiating at some point along St. Paul's insular shelf. Given the relatively restricted range in volcanic phenomena on St. Paul, the most significant question regarding volcano hazard and risk assessment is whether future eruptions will be confined to the same region on the island as the most recent activity. If future activity follows the recent past, resulting volcano hazards will most likely be located at inland areas sufficiently far from habitation that they will pose little threat to life or property. An important caveat, however, is that St. Paul is constructed almost entirely from the products of volcanic eruptions with vents located all over

  14. Toxicology and occupational hazards of new materials and processes in metal surface treatment, powder metallurgy, technical ceramics, and fiber-reinforced plastics.

    PubMed

    Midtgård, U; Jelnes, J E

    1991-12-01

    Many new materials and processes are about to find their way from the research laboratory into industry. The present paper describes some of these processes and provides an overview of possible occupational hazards and a list of chemicals used or produced in the processes. The technological areas that are considered are metal surface treatment (ion implantation, physical and chemical vapor deposition, plasma spraying), powder metallurgy, advanced technical ceramics, and fiber-reinforced plastics.

  15. Poly(L-lactic acid) membranes: absence of genotoxic hazard and potential for drug delivery.

    PubMed

    Uzun, Nelson; Martins, Thomás Duzzi; Teixeira, Gabriella Machado; Cunha, Nayanne Larissa; Oliveira, Rogério Belle; Nassar, Eduardo José; Dos Santos, Raquel Alves

    2015-01-22

    The use of poly(L-lactic acid) (PLA) has been considered an important alternative for medical devices once this polyester presents biomechanical, optical and biodegradable properties. Moreover, the use of PLA results in less inflammatory reactions and more recently it has been proposed its application in drug delivery systems. Genotoxicological evaluations are considered part of the battery assays in toxicological analysis. Considering the wide applications of PLA, the present work evaluated the potential cytotoxic and genotoxic effects of PLA in CHO-K1 cells, as well as its physicochemical properties. No cytotoxic effects of PLA were detected by colorimetric tetrazolium assay (XTT) analysis, and the clonogenic survival assay showed that PLA did not disrupt the replicative cell homeostasis, neither exhibited genotoxic effects as evidenced by comet and micronucleus assays. Thermogravimetric properties of PLA were not altered after contact with cells and this film exhibited ability in absorb and release Europium(III) complex. All these data suggest genotoxicological safety of PLA for further applications in drug delivery systems.

  16. Hazard Potential of Volcanic Flank Collapses Raised by New Megatsunami Evidence

    NASA Astrophysics Data System (ADS)

    Ramalho, R. S.; Winckler, G.; Madeira, J.; Helffrich, G. R.; Hipólito, A.; Quartau, R.; Adena, K.; Schaefer, J. M.

    2015-12-01

    Large-scale gravitational flank collapses of steep volcanic islands are hypothetically capable of triggering megatsunamis with highly catastrophic effects. Yet evidence for the existence and impact of collapsed-triggered megatsunamis and their run-up heights remains scarce and/or is highly contentious. Therefore a considerable debate still exists over the potential magnitude of collapse-triggered tsunamis and their inherent hazard. In particular, doubts still remain whether or not large-scale flank failures typically generate enough volume flux to result in megatsunamis, or alternatively operate by slow-moving or multiple smaller episodic failures with much lower tsunamigenic potential. Here we show that one of the tallest and most active oceanic volcanoes on Earth - Fogo, in the Cape Verde Islands - collapsed catastrophically and triggered a megatsunami with devastating near-field effects ~73,000 years ago. Our deductions are based on the recent discovery and cosmogenic 3He dating of tsunamigenic deposits - comprising fields of stranded megaclasts, chaotic conglomerates, and sand sheets - found on the adjacent Santiago Island, which attest to the impact of this megatsunami and document wave run-up heights exceeding 270 m. The evidence reported here implies that Fogo's flank failure involved at least one sudden and voluminous event that resulted in a megatsunami, in contrast to what has been suggested before. Our work thus provides another line of evidence that large-scale flank failures at steep volcanic islands may indeed happen catastrophically and are capable of triggering tsunamis of enormous height and energy. This new line of evidence therefore reinforces the hazard potential of volcanic island collapses and stands as a warning that such hazard should not be underestimated, particularly in areas where volcanic island edifices are close to other islands or to highly populated continental margins.

  17. Use of short-term test systems for the prediction of the hazard represented by potential chemical carcinogens

    SciTech Connect

    Glass, L.R.; Jones, T.D.; Easterly, C.E.; Walsh, P.J.

    1990-10-01

    It has been hypothesized that results from short-term bioassays will ultimately provide information that will be useful for human health hazard assessment. Historically, the validity of the short-term tests has been assessed using the framework of the epidemiologic/medical screens. In this context, the results of the carcinogen (long-term) bioassay is generally used as the standard. However, this approach is widely recognized as being biased and, because it employs qualitative data, cannot be used to assist in isolating those compounds which may represent a more significant toxicologic hazard than others. In contrast, the goal of this research is to address the problem of evaluating the utility of the short-term tests for hazard assessment using an alternative method of investigation. Chemicals were selected mostly from the list of carcinogens published by the International Agency for Research on Carcinogens (IARC); a few other chemicals commonly recognized as hazardous were included. Tumorigenicity and mutagenicity data on 52 chemicals were obtained from the Registry of Toxic Effects of Chemical Substances (RTECS) and were analyzed using a relative potency approach. The data were evaluated in a format which allowed for a comparison of the ranking of the mutagenic relative potencies of the compounds (as estimated using short-term data) vs. the ranking of the tumorigenic relative potencies (as estimated from the chronic bioassays). Although this was a preliminary investigation, it offers evidence that the short-term tests systems may be of utility in ranking the hazards represented by chemicals which may contribute to increased carcinogenesis in humans as a result of occupational or environmental exposures. 177 refs., 8 tabs.

  18. Coastal flooding hazard assessment on potentially vulnerable coastal sectors at Varna regional coast

    NASA Astrophysics Data System (ADS)

    Eftimova, Petya; Valchev, Nikolay; Andreeva, Nataliya

    2017-04-01

    Storm induced flooding is one of the most significant threats that the coastal communities face. In the light of the climate change it is expected to gain even more importance. Therefore, the adequate assessment of this hazard could increase the capability of mitigation of environmental, social, and economic impacts. The study was accomplished in the frames of the Coastal Risk Assessment Framework (CRAF) developed within the FP7 RISC-KIT Project (Resilience-Increasing Strategies for Coasts - toolkit). The hazard assessment was applied on three potentially vulnerable coastal sectors located at the regional coast of Varna, Bulgarian Black Sea coast. The potential "hotspot" candidates were selected during the initial phase of CRAF which evaluated the coastal risks at regional level. The area of interest comprises different coastal types - from natural beaches and rocky cliffs to man modified environments presented by coastal and port defense structures such as the Varna Port breakwater, groynes, jetties and beaches formed by the presence of coastal structures. The assessment of coastal flooding was done using combination of models -XBeach model and LISFLOOD inundation model applied consecutively. The XBeach model was employed to calculate the hazard intensities at the coast up to the berm crest, while LISFLOOD model was used to calculate the intensity and extent of flooding in the hinterland. At the first stage, 75 extreme storm events were simulated using XBeach model run in "non-hydrostatic" mode to obtain series of flood depth, depth-velocity and overtopping discharges at the predefined coastal cross-shore transects. Extreme value analysis was applied to the calculated hazard parameters series in order to determine their probability distribution functions. This is so called response approach, which is focused on the onshore impact rather than on the deep water boundary conditions. It allows calculation of the hazard extremes probability distribution induced by a

  19. Broad-band Photometry of the Potentially Hazardous Asteroid 2006 DP14

    NASA Astrophysics Data System (ADS)

    Hicks, M.; Ebelhar, S.

    2014-02-01

    The nearr-Earth Asteroid (NEA) 2006 DP14 was discovered by the LINEAR asteroid discovery program on February 23, 2006 (MPEC 2006-D40). With a likely diameter on the order of ~500 meters and a Minimum Orbit Intersection Distance MOID = 0.016 AU, the object has been designated as a Potentially Hazardous Asteroid (PHA) by the Minor Planet Center. Delay-doppler radar imaging was obtained by the JPL Planetary Radar Team at Goldstone on February 12, 2014 (http://echo.jpl.nasa.gov/asteroids/2006DP14/2006DP14_planning.html).

  20. Investigating the composition of Potentially Hazardous Asteroids with the NEO-SURFACE survey

    NASA Astrophysics Data System (ADS)

    Ieva, S.; Dotto, E.; Perna, D.; Barucci, M. A.; Bernardi, F.; Perozzi, E.; Micheli, M.; Mazzotta Epifani, E.; Brucato, J. R.; Fornasier, S.; De Luise, F.; Rossi, A.

    2015-10-01

    There is a high degree of diversity among the physical properties of the Potentially Hazardous asteroids (PHAs). For these objects, the physical characterization is essential to define a successful mitigation mission, therefore ground-based surveys like NEO-SURFACE could provide a fundamental contribution. Our analysis suggest a prevalence of silicate S-types in the PHA population, which could be due in principle to the high efficiency of the transport mechanisms in the inner main belt, or to an observational bias due to the fact that S-types are brighter.

  1. Dynamics of data change on potentially hazardous asteroids, observed at one opposition.

    NASA Astrophysics Data System (ADS)

    Syusina, O. M.; Chernitsov, A. M.; Tamarov, V. A.

    2014-12-01

    The problem of creation of confidence region of the movement of an asteroid can be solved either in the linear or nonlinear way depending on degree of its nonlinearity. To make a right choice between us-ages of linear or nonlinear approach earlier we proposed to calculate the factor characterizing degree of nonlinearity of the solved problem [1]. Creation of confidence region of the movement of an asteroid means definition of initial region and its subsequent one-parametrical display in time. Wherein the correct approach to creation of initial region is determines the accuracy of the description of the probabilistic movement of an asteroid in general. In case of asteroids observed more than in one opposition, the prob-lem of definition of initial region, typically, is weakly nonlinear, and for its solution it is acceptable to use linear methods. In case of the asteroids observed only in one opposition, preliminary calculation of non-linearity factor plays an important role in a choice between linear or nonlinear methods. In our previous work [2] values of nonlinearity factor for all potentially hazardous asteroids, observed in one opposition, were determined according to the data published by the Minor Planet Center for March, 2014 [3]. The studied asteroids were broken into groups: with a factor of nonlinearity less than 0.01, in the range from 0.01 to 0.1, and more than 0.1. With this work we began to create constantly updating database "Poten-tially Hazardous Asteroids Observed in One Opposition" hosted on the site of department of astronomy and space geodesy of Tomsk state university (http://astro.tsu.ru). The database will contain factors of non-linearity and accuracy of models of the movement, and also an assessment of probability of collisions with Earth of all potentially hazardous asteroids observed in one opposition. The purpose of the given work is to track dynamics of change of the published by MPC data about such asteroids during the period from 2010

  2. Reactions of plutonium and uranium with water: Kinetics and potential hazards

    SciTech Connect

    Haschke, J.M.

    1995-12-01

    The chemistry and kinetics of reactions between water and the metals and hydrides of plutonium and uranium are described in an effort to consolidate information for assessing potential hazards associated with handling and storage. New experimental results and data from literature sources are presented. Kinetic dependencies on pH, salt concentration, temperature and other parameters are reviewed. Corrosion reactions of the metals in near-neutral solutions produce a fine hydridic powder plus hydrogen. The corrosion rate for plutonium in sea water is a thousand-fold faster than for the metal in distilled water and more than a thousand-fold faster than for uranium in sea water. Reaction rates for immersed hydrides of plutonium and uranium are comparable and slower than the corrosion rates for the respective metals. However, uranium trihydride is reported to react violently if a quantity greater than twenty-five grams is rapidly immersed in water. The possibility of a similar autothermic reaction for large quantities of plutonium hydride cannot be excluded. In addition to producing hydrogen, corrosion reactions convert the massive metals into material forms that are readily suspended in water and that are aerosolizable and potentially pyrophoric when dry. Potential hazards associated with criticality, environmental dispersal, spontaneous ignition and explosive gas mixtures are outlined.

  3. Coal seam gas water: potential hazards and exposure pathways in Queensland.

    PubMed

    Navi, Maryam; Skelly, Chris; Taulis, Mauricio; Nasiri, Shahram

    2015-01-01

    The extraction of coal seam gas (CSG) produces large volumes of potentially contaminated water. It has raised concerns about the environmental health impacts of the co-produced CSG water. In this paper, we review CSG water contaminants and their potential health effects in the context of exposure pathways in Queensland's CSG basins. The hazardous substances associated with CSG water in Queensland include fluoride, boron, lead and benzene. The exposure pathways for CSG water are (1) water used for municipal purposes; (2) recreational water activities in rivers; (3) occupational exposures; (4) water extracted from contaminated aquifers; and (5) indirect exposure through the food chain. We recommend mapping of exposure pathways into communities in CSG regions to determine the potentially exposed populations in Queensland. Future efforts to monitor chemicals of concern and consolidate them into a central database will build the necessary capability to undertake a much needed environmental health impact assessment.

  4. Use of health hazard criteria for estimating the hazard potential of chemicals to water in case of a spill.

    PubMed

    Höfer, T; Steinhäuser, K G

    2000-02-01

    Accidental spills resulting in severe pollution can occur during transportation or handling of large volumes of chemicals. To address this problem, chemicals are classified according to the level of hazard to man and the environment in order to then define graduated technical standards. Three regulatory examples (enforced or drafted for transport and industrial installations in Europe) covering aspects of limnic as well as sea water are discussed in regard to health aspects of pollution. Whereas for the safety of seagoing tankships an exposure orientated combination of health and environmental aspects is used, for industrial plants in Germany a scoring system based on the European Union's Risk Phrase system is applied. The health-related parameters primarily used for hazard classification are repeated-dose toxicity and acute oral and dermal toxicity. Acute oral toxicity is most widely used because of the ready availability of data. Carcinogenicity is treated as the most important hazard. The report discusses the importance of dermal exposure, aspiration, and endocrine disruption as parameters as well as the importance of health criteria for the protection of aquatic organisms. Copyright 2000 Academic Press.

  5. Alcohols toxicology

    SciTech Connect

    Wimer, W.W.; Russell, J.A.; Kaplan, H.L.

    1984-01-01

    A comprehensive reference volume which summarizes literature reports of the known consequences of human and animal contact with alcohols and alcohol-derived substances is presented. Following a discussion of alcohol nomenclature and a brief history of alcohols, the authors have provided detailed chapters on the toxicology of methanol, ethanol, normal and isopropanol, and the butanols. Properties of these alcohols are compared; industrial hygiene and exposure limits are discussed. Additional sections are included covering processing and production technology and exhaust emissions studies. Of particular interest are the section containing abstracts and synopses of principal works and the extensive bibliography of studies dating from the 1800s. 331 references, 26 figures, 56 tables

  6. [Food toxicology].

    PubMed

    Würzner, H P

    1984-02-01

    The complex problems of food toxicology and especially of mutagenesis and carcinogenesis require continuing efforts for a better understanding of the mechanisms, risk evaluation and prevention. Essential progress was the recognition of mutation. In vitro tests now provide reproducible results within a short time. Risk evaluation remains a difficult problem, since is has not been possible yet to establish thresholds values for genotoxic substances. However, threshold levels for carcinogen promoters gain increasing importance as demonstrated for 3 representative classes of substances: mycotoxines , nitrosamines and pesticides.

  7. Behavioral toxicology

    SciTech Connect

    Needleman, H.L.

    1995-09-01

    The new fields of behavioral toxicology and behavioral teratology investigate the outcome of specific toxic exposures in humans and animals on learning, memory, and behavioral characteristics. Three important classes of behavioral neurotoxicants are metals, solvents, and pesticides. The clearest data on the deleterious effects of prenatal exposure to toxicants comes from the study of two metals, lead and mercury, and form epidemiological investigations of the effects of alcohol taken during pregnancy. Less complete data are available for two other groups of agents, solvents, and pesticides. What we do know about their effects on the fetal brain is convincing enough to make us demand caution in their distribution. 15 refs.

  8. IRIS Toxicological Review of Tetrahydrofuran (THF) ...

    EPA Pesticide Factsheets

    EPA is releasing the draft report, Toxicological Review of Tetrahydrofuran, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments. EPA is undertaking an Integrated Risk Information System (IRIS) health assessment for tetrahydrofuran. IRIS is an EPA database containing Agency scientific positions on potential adverse human health effects that may result from chronic (or lifetime) exposure to chemicals in the environment. IRIS contains chemical-specific summaries of qualitative and quantitative health information in support of two steps of the risk assessment paradigm, i.e., hazard identification and dose-response evaluation. IRIS assessments are used in combination with specific situational exposure assessment information to evaluate potential public health risk associated with environmental contaminants.

  9. Aspect Ratio Plays a Role in the Hazard Potential of CeO2 Nanoparticles in Mouse Lung and Zebrafish Gastrointestinal Tract

    PubMed Central

    Lin, Sijie; Wang, Xiang; Ji, Zhaoxia; Chang, Chong Hyun; Dong, Yuan; Meng, Huan; Liao, Yu-Pei; Wang, Meiying; Song, Tze-Bin; Kohan, Sirus; Xia, Tian; Zink, Jeffrey I.; Lin, Shuo; Nel, André E.

    2014-01-01

    We have previously demonstrated that there is a relationship between the aspect ratio (AR) of CeO2 nanoparticles and in vitro hazard potential. CeO2 nanorods with AR ≥ 22 induced lysosomal damage and progressive effects on IL-1β production and cytotoxicity in the human myeloid cell line, THP-1. In order to determine whether this toxicological paradigm for long aspect ratio (LAR) CeO2 is also relevant in vivo, we performed comparative studies in the mouse lung and gastrointestinal tract (GIT) of zebrafish larvae. Although oropharyngeal aspiration could induce acute lung inflammation for CeO2 nanospheres and nanorods, only the nanorods with the highest AR (C5) induced significant IL-1β and TGF-β1 production in the bronchoalveolar lavage fluid (BALF) at 21 days but not inducing pulmonary fibrosis. However, after a longer duration (44 days) exposure to 4 mg/kg of the C5 nanorods, more collagen production was seen with CeO2 nanorods vs. nanospheres after correcting for Ce lung burden. Using an oral-exposure model in zebrafish larvae, we demonstrated that C5 nanorods also induced significant growth inhibition, a decrease in body weight, and delayed vertebral calcification. In contrast, CeO2 nanospheres and shorter nanorods had no effect. Histological and transmission electron microscopy (TEM) analyses showed that the key injury mechanism of C5 was in the epithelial lining of the GIT, which demonstrated blunted microvilli and compromised digestive function. All considered, these data demonstrate that, similar to cellular studies, LAR CeO2 nanorods exhibit more toxicity in the lung and GIT, which could be relevant to inhalation and environmental hazard potential. PMID:24720650

  10. Aspect ratio plays a role in the hazard potential of CeO2 nanoparticles in mouse lung and zebrafish gastrointestinal tract.

    PubMed

    Lin, Sijie; Wang, Xiang; Ji, Zhaoxia; Chang, Chong Hyun; Dong, Yuan; Meng, Huan; Liao, Yu-Pei; Wang, Meiying; Song, Tze-Bin; Kohan, Sirus; Xia, Tian; Zink, Jeffrey I; Lin, Shuo; Nel, André E

    2014-05-27

    We have previously demonstrated that there is a relationship between the aspect ratio (AR) of CeO2 nanoparticles and in vitro hazard potential. CeO2 nanorods with AR ≥ 22 induced lysosomal damage and progressive effects on IL-1β production and cytotoxicity in the human myeloid cell line, THP-1. In order to determine whether this toxicological paradigm for long aspect ratio (LAR) CeO2 is also relevant in vivo, we performed comparative studies in the mouse lung and gastrointestinal tract (GIT) of zebrafish larvae. Although oropharyngeal aspiration could induce acute lung inflammation for CeO2 nanospheres and nanorods, only the nanorods with the highest AR (C5) induced significant IL-1β and TGF-β1 production in the bronchoalveolar lavage fluid at 21 days but did not induce pulmonary fibrosis. However, after a longer duration (44 days) exposure to 4 mg/kg of the C5 nanorods, more collagen production was seen with CeO2 nanorods vs nanospheres after correcting for Ce lung burden. Using an oral-exposure model in zebrafish larvae, we demonstrated that C5 nanorods also induced significant growth inhibition, a decrease in body weight, and delayed vertebral calcification. In contrast, CeO2 nanospheres and shorter nanorods had no effect. Histological and transmission electron microscopy analyses showed that the key injury mechanism of C5 was in the epithelial lining of the GIT, which demonstrated blunted microvilli and compromised digestive function. All considered, these data demonstrate that, similar to cellular studies, LAR CeO2 nanorods exhibit more toxicity in the lung and GIT, which could be relevant to inhalation and environmental hazard potential.

  11. Site-specific seismic probabilistic tsunami hazard analysis: performances and potential applications

    NASA Astrophysics Data System (ADS)

    Tonini, Roberto; Volpe, Manuela; Lorito, Stefano; Selva, Jacopo; Orefice, Simone; Graziani, Laura; Brizuela, Beatriz; Smedile, Alessandra; Romano, Fabrizio; De Martini, Paolo Marco; Maramai, Alessandra; Piatanesi, Alessio; Pantosti, Daniela

    2017-04-01

    Seismic Probabilistic Tsunami Hazard Analysis (SPTHA) provides probabilities to exceed different thresholds of tsunami hazard intensity, at a specific site or region and in a given time span, for tsunamis caused by seismic sources. Results obtained by SPTHA (i.e., probabilistic hazard curves and inundation maps) represent a very important input to risk analyses and land use planning. However, the large variability of source parameters implies the definition of a huge number of potential tsunami scenarios, whose omission could lead to a biased analysis. Moreover, tsunami propagation from source to target requires the use of very expensive numerical simulations. At regional scale, the computational cost can be reduced using assumptions on the tsunami modeling (i.e., neglecting non-linear effects, using coarse topo-bathymetric meshes, empirically extrapolating maximum wave heights on the coast). On the other hand, moving to local scale, a much higher resolution is required and such assumptions drop out, since detailed inundation maps require significantly greater computational resources. In this work we apply a multi-step method to perform a site-specific SPTHA which can be summarized in the following steps: i) to perform a regional hazard assessment to account for both the aleatory and epistemic uncertainties of the seismic source, by combining the use of an event tree and an ensemble modeling technique; ii) to apply a filtering procedure which use a cluster analysis to define a significantly reduced number of representative scenarios contributing to the hazard of a specific target site; iii) to perform high resolution numerical simulations only for these representative scenarios and for a subset of near field sources placed in very shallow waters and/or whose coseismic displacements induce ground uplift or subsidence at the target. The method is applied to three target areas in the Mediterranean located around the cities of Milazzo (Italy), Thessaloniki (Greece) and

  12. IRIS Toxicological Review of Dichloromethane (Methylene ...

    EPA Pesticide Factsheets

    EPA is releasing the draft report, Toxicological Review of Dichloromethane, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments. The draft Toxicological Review of Dichloromethane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to dichloromethane.

  13. IRIS Toxicological Review of Urea (Interagency Science ...

    EPA Pesticide Factsheets

    EPA is releasing the draft report, Toxicological Review of Urea,, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments. The draft Toxicological Review of Urea provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to Urea.

  14. IRIS Toxicological Review of Trichloroacetic Acid (TCA) ...

    EPA Pesticide Factsheets

    EPA is releasing the draft report, Toxicological Review of Trichloroacetic Acid (TCA), that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments. The draft Toxicological Review of Trichloroacetic Acid provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to trichloroacetic acid.

  15. IRIS Toxicological Review of Trichloroacetic Acid (TCA) ...

    EPA Pesticide Factsheets

    EPA is releasing the draft report, Toxicological Review of Trichloroacetic Acid (TCA), that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments. The draft Toxicological Review of Trichloroacetic Acid provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to trichloroacetic acid.

  16. VizieR Online Data Catalog: Taxonomy of potentially hazardous asteroids (Perna+, 2016)

    NASA Astrophysics Data System (ADS)

    Perna, D.; Dotto, E.; Ieva, S.; Barucci, M. A.; Bernardi, F.; Fornasier, S.; de Luise, F.; Perozzi, E.; Rossi, A.; Epifani, E. M.; Micheli, M.; Deshapriya, J. D. P.

    2016-07-01

    Observations of 14 Potentially Hazardous Asteroids (PHAs) were carried out at the 3.6-m Telescopio Nazionale Galileo (TNG, La Palma, Spain), the ESO 3.6-m New Technology Telescope (NTT, La Silla, Chile), and the NASA 3.0-m Infrared Telescope Facility (IRTF, Mauna Kea, USA). The observational circumstances, as well as the instrumentation used are given in Table1. According to the population model by Mainzer et al. (2012ApJ...752..110M), ~4700+/-1450 PHAs are expected to exist. To further investigate the PHA population as a whole, and in particular to verify how the different taxonomic types are distributed with respect to other physical and dynamical properties, we combined our results with the available literature. We started retrieving the European Asteroid Research Node (EARN; http://earn.dlr.de/; retrieved on 2015 April 28) database of Near-Earth Object (NEO) physical properties, selecting those 255 Potentially Hazardous Asteroids (PHAs) with published taxonomic classifications. Of our 14 targets, 7 are classified in the present work for the first time, for a total sample of 262 targets to be considered in our analysis (see Table4). The results for our remaining seven targets are in agreement with the literature. (2 data files).

  17. Hazard potential of volcanic flank collapses raised by new megatsunami evidence

    PubMed Central

    Ramalho, Ricardo S.; Winckler, Gisela; Madeira, José; Helffrich, George R.; Hipólito, Ana; Quartau, Rui; Adena, Katherine; Schaefer, Joerg M.

    2015-01-01

    Large-scale gravitational flank collapses of steep volcanic islands are hypothetically capable of triggering megatsunamis with highly catastrophic effects. Yet, evidence for the generation and impact of collapse-triggered megatsunamis and their high run-ups remains scarce or is highly controversial. Therefore, doubts remain on whether island flank failures truly generate enough volume flux to trigger giant tsunamis, leading to diverging opinions concerning the real hazard potential of such collapses. We show that one of the most prominent oceanic volcanoes on Earth—Fogo, in the Cape Verde Islands—catastrophically collapsed and triggered a megatsunami with devastating effects ~73,000 years ago. Our deductions are based on the recent discovery and cosmogenic 3He dating of tsunamigenic deposits found on nearby Santiago Island, which attest to the impact of this giant tsunami and document wave run-up heights exceeding 270 m. The evidence reported here implies that Fogo’s flank failure involved at least one fast and voluminous event that led to a giant tsunami, in contrast to what has been suggested before. Our observations therefore further demonstrate that flank collapses may indeed catastrophically happen and are capable of triggering tsunamis of enormous height and energy, adding to their hazard potential. PMID:26601287

  18. Tsunami Hazards along the Eastern Australian Coast from Potential Earthquakes: Results from Numerical Simulations

    NASA Astrophysics Data System (ADS)

    Xing, H. L.; Ding, R. W.; Yuen, D. A.

    2015-08-01

    Australia is surrounded by the Pacific Ocean and the Indian Ocean and, thus, may suffer from tsunamis due to its proximity to the subduction earthquakes around the boundary of Australian Plate. Potential tsunami risks along the eastern coast, where more and more people currently live, are numerically investigated through a scenario-based method to provide an estimation of the tsunami hazard in this region. We have chosen and calculated the tsunami waves generated at the New Hebrides Trench and the Puysegur Trench, and we further investigated the relevant tsunami hazards along the eastern coast and their sensitivities to various sea floor frictions and earthquake parameters (i.e. the strike, the dip and the slip angles and the earthquake magnitude/rupture length). The results indicate that the Puysegur trench possesses a seismic threat causing wave amplitudes over 1.5 m along the coast of Tasmania, Victoria, and New South Wales, and even reaching over 2.6 m at the regions close to Sydney, Maria Island, and Gabo Island for a certain worse case, while the cities along the coast of Queensland are potentially less vulnerable than those on the southeastern Australian coast.

  19. Hazard potential of volcanic flank collapses raised by new megatsunami evidence.

    PubMed

    Ramalho, Ricardo S; Winckler, Gisela; Madeira, José; Helffrich, George R; Hipólito, Ana; Quartau, Rui; Adena, Katherine; Schaefer, Joerg M

    2015-10-01

    Large-scale gravitational flank collapses of steep volcanic islands are hypothetically capable of triggering megatsunamis with highly catastrophic effects. Yet, evidence for the generation and impact of collapse-triggered megatsunamis and their high run-ups remains scarce or is highly controversial. Therefore, doubts remain on whether island flank failures truly generate enough volume flux to trigger giant tsunamis, leading to diverging opinions concerning the real hazard potential of such collapses. We show that one of the most prominent oceanic volcanoes on Earth-Fogo, in the Cape Verde Islands-catastrophically collapsed and triggered a megatsunami with devastating effects ~73,000 years ago. Our deductions are based on the recent discovery and cosmogenic (3)He dating of tsunamigenic deposits found on nearby Santiago Island, which attest to the impact of this giant tsunami and document wave run-up heights exceeding 270 m. The evidence reported here implies that Fogo's flank failure involved at least one fast and voluminous event that led to a giant tsunami, in contrast to what has been suggested before. Our observations therefore further demonstrate that flank collapses may indeed catastrophically happen and are capable of triggering tsunamis of enormous height and energy, adding to their hazard potential.

  20. A method for assessing the potential for a dermal burn hazard from malfunctioning consumer electronic devices.

    PubMed

    Mikolajczak, Celina J; Taylor, Paul M

    2008-01-01

    We developed an approach to adapt the ASTM C1055-03 Standard to assess the potential for contact burn injury from portable consumer electronic devices. The approach involves measuring the maximum temperature profile during the fault and devising a way to reproduce these temperatures in an exemplar device in a controlled manner for thermesthesiometer measurements. By comparing the results of the thermesthesiometer measurements to the contact burn injury threshold data published in ASTM C1055-03 and various guidelines for unintentional contact times, we were able to predict whether a potential hazard exists and verify result with "finger tests." We applied this method on a number of occasions to assess the likelihood of a contact burn injury resulting from a fault arising inside portable consumer electronic devices.

  1. Evaluation of the Potential of NASA Multi-satellite Precipitation Analysis in Global Landslide Hazard Assessment

    NASA Technical Reports Server (NTRS)

    Hong, Yang; Adler, Robert F.; Huffman, George J.

    2007-01-01

    Landslides are one of the most widespread natural hazards on Earth, responsible for thousands of deaths and billions of dollars in property damage every year. In the U.S. alone landslides occur in every state, causing an estimated $2 billion in damage and 25- 50 deaths each year. Annual average loss of life from landslide hazards in Japan is 170. The situation is much worse in developing countries and remote mountainous regions due to lack of financial resources and inadequate disaster management ability. Recently, a landslide buried an entire village on the Philippines Island of Leyte on Feb 17,2006, with at least 1800 reported deaths and only 3 houses left standing of the original 300. Intense storms with high-intensity , long-duration rainfall have great potential to trigger rapidly moving landslides, resulting in casualties and property damage across the world. In recent years, through the availability of remotely sensed datasets, it has become possible to conduct global-scale landslide hazard assessment. This paper evaluates the potential of the real-time NASA TRMM-based Multi-satellite Precipitation Analysis (TMPA) system to advance our understanding of and predictive ability for rainfall-triggered landslides. Early results show that the landslide occurrences are closely associated with the spatial patterns and temporal distribution of rainfall characteristics. Particularly, the number of landslide occurrences and the relative importance of rainfall in triggering landslides rely on the influence of rainfall attributes [e.g. rainfall climatology, antecedent rainfall accumulation, and intensity-duration of rainstorms). TMPA precipitation data are available in both real-time and post-real-time versions, which are useful to assess the location and timing of rainfall-triggered landslide hazards by monitoring landslide-prone areas while receiving heavy rainfall. For the purpose of identifying rainfall-triggered landslides, an empirical global rainfall intensity

  2. Genetic polymorphisms in human drug-metabolizing enzymes: potential uses of reverse genetics to identify genes of toxicological relevance.

    PubMed

    Puga, A; Nebert, D W; McKinnon, R A; Menon, A G

    1997-03-01

    The human mind was engaged with fundamental questions on the nature of heredity long before the study of genetics became a scientific discipline. Many traits, such as height, eye color, blood pressure, or cancer susceptibility, have been known to run in families, although the genes or combination of genes that underlie these observable characteristics remain unknown in most cases. Differences in susceptibility to environmental agents in humans are likewise determined by variations in genetic background--genetic polymorphisms. In this article, we review the current status of studies on human polymorphisms in drug-metabolizing enzymes and discuss various approaches to the analysis of genetic polymorphisms. We expect that in the near future, novel methods in genetic analysis of human populations will be likely to play a key role in the identification of genes of toxicological relevance.

  3. Integrating zebrafish toxicology and nanoscience for safer product development

    PubMed Central

    Kim, Ki-Tae; Tanguay, Robert L.

    2013-01-01

    The design, manufacture and application of safer products and manufacturing processes have been important goals over the last decade and will advance in the future under the umbrella of "Green Chemistry". In this review, we focus on the burgeoning diversity of new engineered nanomaterials (ENMs) and the prescient need for a nanotoxicology paradigm that quickly identifies potentially hazardous nanochemistries. Advances in predictive toxicological modeling in the developing zebrafish offer the most immediate translation to human hazard that is practically achievable with high throughput approaches. Translation in a vertebrate model that is also a low cost alternative to rodents for hazard prediction has been a desirable but elusive testing paradigm. The utility of zebrafish, if applied early in the ENM discovery pipeline, could greatly enhance efforts toward greener and more efficient nanoscience. Early pipeline detection of human and environmental health impacts will quickly inform decisions in the design and production of safer commercial ENMs. PMID:23772181

  4. Integrating zebrafish toxicology and nanoscience for safer product development.

    PubMed

    Kim, Ki-Tae; Tanguay, Robert L

    2013-04-01

    The design, manufacture and application of safer products and manufacturing processes have been important goals over the last decade and will advance in the future under the umbrella of "Green Chemistry". In this review, we focus on the burgeoning diversity of new engineered nanomaterials (ENMs) and the prescient need for a nanotoxicology paradigm that quickly identifies potentially hazardous nanochemistries. Advances in predictive toxicological modeling in the developing zebrafish offer the most immediate translation to human hazard that is practically achievable with high throughput approaches. Translation in a vertebrate model that is also a low cost alternative to rodents for hazard prediction has been a desirable but elusive testing paradigm. The utility of zebrafish, if applied early in the ENM discovery pipeline, could greatly enhance efforts toward greener and more efficient nanoscience. Early pipeline detection of human and environmental health impacts will quickly inform decisions in the design and production of safer commercial ENMs.

  5. Influence of potential sea level rise on societal vulnerability to hurricane storm-surge hazards, Sarasota County, Florida

    USGS Publications Warehouse

    Frazier, Tim G.; Wood, Nathan; Yarnal, Brent; Bauer, Denise H.

    2010-01-01

    Although the potential for hurricanes under current climatic conditions continue to threaten coastal communities, there is concern that climate change, specifically potential increases in sea level, could influence the impacts of future hurricanes. To examine the potential effect of sea level rise on community vulnerability to future hurricanes, we assess variations in socioeconomic exposure in Sarasota County, FL, to contemporary hurricane storm-surge hazards and to storm-surge hazards enhanced by sea level rise scenarios. Analysis indicates that significant portions of the population, economic activity, and critical facilities are in contemporary and future hurricane storm-surge hazard zones. The addition of sea level rise to contemporary storm-surge hazard zones effectively causes population and asset (infrastructure, natural resources, etc) exposure to be equal to or greater than what is in the hazard zone of the next higher contemporary Saffir–Simpson hurricane category. There is variability among communities for this increased exposure, with greater increases in socioeconomic exposure due to the addition of sea level rise to storm-surge hazard zones as one progresses south along the shoreline. Analysis of the 2050 comprehensive land use plan suggests efforts to manage future growth in residential, economic and infrastructure development in Sarasota County may increase societal exposure to hurricane storm-surge hazards.

  6. Influence of potential sea level rise on societal vulnerability to hurricane storm-surge hazards, Sarasota County, Florida

    USGS Publications Warehouse

    Frazier, T.G.; Wood, N.; Yarnal, B.; Bauer, D.H.

    2010-01-01

    Although the potential for hurricanes under current climatic conditions continue to threaten coastal communities, there is concern that climate change, specifically potential increases in sea level, could influence the impacts of future hurricanes. To examine the potential effect of sea level rise on community vulnerability to future hurricanes, we assess variations in socioeconomic exposure in Sarasota County, FL, to contemporary hurricane storm-surge hazards and to storm-surge hazards enhanced by sea level rise scenarios. Analysis indicates that significant portions of the population, economic activity, and critical facilities are in contemporary and future hurricane storm-surge hazard zones. The addition of sea level rise to contemporary storm-surge hazard zones effectively causes population and asset (infrastructure, natural resources, etc) exposure to be equal to or greater than what is in the hazard zone of the next higher contemporary Saffir-Simpson hurricane category. There is variability among communities for this increased exposure, with greater increases in socioeconomic exposure due to the addition of sea level rise to storm-surge hazard zones as one progresses south along the shoreline. Analysis of the 2050 comprehensive land use plan suggests efforts to manage future growth in residential, economic and infrastructure development in Sarasota County may increase societal exposure to hurricane storm-surge hazards. ?? 2010 Elsevier Ltd.

  7. Toxicology evaluation and hazard review for non-CFC containing rigid foams BKC 44317 and last-a-foam MSL-02A

    SciTech Connect

    Greulich, K.A.; Archuleta, M.M.

    1996-06-01

    New pour-in-place, low density, rigid polyurethane foam kits have been developed to mechanically stabilize damaged explosive ordnance. Although earlier foam systems used chlorofluorocarbons as blowing agents, the current versions rely on carbon dioxide generated by the reaction of isocynates with water. In addition, these kits were developed to manually generate small quantifies of rigid foam in the field with minimal or no protective equipment. The purpose of this study was to evaluate and summarize available hazard information for the components of these rigid foam kits and to provide recommendations for personal protective equipment to be used while performing the manual combination of the components. As with most rigid foam systems, these kits consist of two parts, one a mixture of isocyanates; the other, a combination of polyols, surfactants, and amine catalysts. Once completely deployed, the rigid foam is non-toxic. The components, however, have some important health effects which must be considered when establishing handling procedures.

  8. IRIS Toxicological Review of Ammonia Noncancer Inhalation ...

    EPA Pesticide Factsheets

    In September 2016, EPA finalized the IRIS assessment of Ammonia (Noncancer Inhalation). The Toxicological Review was reviewed internally by EPA and by other federal agencies and White House Offices before public release in June 2016. Consistent with the May 2009 IRIS assessment development process, all written comments on IRIS assessments submitted by other federal agencies and White House Offices are made publicly available. Accordingly, interagency comments and the interagency science discussion materials provided to other agencies, including interagency review drafts of the IRIS Toxicological Review of Ammonia (Noncancer Inhalation) are posted on this site. Note: No major science comments were received on the Interagency Science Discussion Draft. EPA is undertaking an Integrated Risk Information System (IRIS) health assessment for ammonia. IRIS is an EPA database containing Agency scientific positions on potential adverse human health effects that may result from chronic (or lifetime) exposure to chemicals in the environment. IRIS contains chemical-specific summaries of qualitative and quantitative health information in support of two steps of the risk assessment paradigm, i.e., hazard identification and dose-response evaluation. IRIS assessments are used in combination with specific situational exposure assessment information to evaluate potential public health risk associated with environmental contaminants.

  9. Probabilistic seismic hazard assessment based on seismic potential of active faults: Example from northern Algeria

    NASA Astrophysics Data System (ADS)

    Bouhadad, Youcef

    2017-04-01

    Northern Algeria is an interplate area where the African and the Eurasian tectonic plates are converging in the NW-SE direction. Therefore, earthquakes are not distributed randomly but directly related to the activity of active faults. The seismotectonic conditions of occurrence of strong damaging earthquakes in the area are well understood following the numerous detailed studies that followed the El-Asnam October 10th , 1980 earthquake (Ms=7.3) and the Zemmouri May 1st , 2003 (Mw=6.8) earthquake. The potentially active structures consist of active folds or asymmetrical folds underlined by thrust faults. Some of the faults are blind as revealed by the Chenoua 29th , 1989 (Ms=6.0) and the Ain Temouchent 1999 (Ms=5.6) earthquakes. We applied the probabilistic approach to assess seismic hazard in the area of Mostaganem, western Algeria. The following steps are performed (i) Seismic sources are identified on the basis of field geological/geophysical investigations,(ii) Source parameters such as b-values, slip rate and maximum magnitude are assessed for each seismic source, and then given a weight in the framework of a logic tree model, (iii) Attenuation relations which fit Algerian strong motion records are used, (iv) Results are presented as annual frequencies of exceedance versus peak ground acceleration (PGA) as well as maps of hazard for different return periods. Finally, we quantified and discussed the scientific uncertainties related to the state of knowledge and the used alternative models and values. Keywords: seismic hazard- active faults- probabilistic approach- uncertainties-Algeria

  10. Electromagnetic interference from radio frequency identification inducing potentially hazardous incidents in critical care medical equipment.

    PubMed

    van der Togt, Remko; van Lieshout, Erik Jan; Hensbroek, Reinout; Beinat, E; Binnekade, J M; Bakker, P J M

    2008-06-25

    Health care applications of autoidentification technologies, such as radio frequency identification (RFID), have been proposed to improve patient safety and also the tracking and tracing of medical equipment. However, electromagnetic interference (EMI) by RFID on medical devices has never been reported. To assess and classify incidents of EMI by RFID on critical care equipment. Without a patient being connected, EMI by 2 RFID systems (active 125 kHz and passive 868 MHz) was assessed under controlled conditions during May 2006, in the proximity of 41 medical devices (in 17 categories, 22 different manufacturers) at the Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. Assessment took place according to an international test protocol. Incidents of EMI were classified according to a critical care adverse events scale as hazardous, significant, or light. In 123 EMI tests (3 per medical device), RFID induced 34 EMI incidents: 22 were classified as hazardous, 2 as significant, and 10 as light. The passive 868-MHz RFID signal induced a higher number of incidents (26 incidents in 41 EMI tests; 63%) compared with the active 125-kHz RFID signal (8 incidents in 41 EMI tests; 20%); difference 44% (95% confidence interval, 27%-53%; P < .001). The passive 868-MHz RFID signal induced EMI in 26 medical devices, including 8 that were also affected by the active 125-kHz RFID signal (26 in 41 devices; 63%). The median distance between the RFID reader and the medical device in all EMI incidents was 30 cm (range, 0.1-600 cm). In a controlled nonclinical setting, RFID induced potentially hazardous incidents in medical devices. Implementation of RFID in the critical care environment should require on-site EMI tests and updates of international standards.

  11. Potential hazards of environmental contaminants to avifauna residing in the Chesapeake Bay estuary

    USGS Publications Warehouse

    Rattner, Barnett A.; McGowan, Peter C.

    2007-01-01

    A search of the Contaminant Exposure and Effects-Terrestrial Vertebrates (CEE-TV) database revealed that 70% of the 839 Chesapeake Bay records deal with avian species. Studies conducted on waterbirds in the past 15 years indicate that organochlorine contaminants have declined in eggs and tissues, although p,p'-DDE, total polychlorinated biphenyls (PCBs) and coplanar PCB congeners may still exert sublethal and reproductive effects in some locations. There have been numerous reports of avian die-off events related to organophosphorus and carbamate pesticides. More contemporary contaminants (e.g., alkylphenols, ethoxylates, perfluorinated compounds, polybrominated diphenyl ethers) are detectable in bird eggs in the most industrialized portions of the Bay, but interpretation of these data is difficult because adverse effect levels are incompletely known for birds. Two moderaterized oil spills resulted in the death of several hundred birds, and about 500 smaller spill events occur annually in the watershed. With the exception of lead, concentrations of cadmium, mercury, and selenium in eggs and tissues appear to be below toxic thresholds for waterbirds. Fishing tackle and discarded plastics, that can entangle and kill young and adults, are prevalent in nests in some Bay tributaries. It is apparent that exposure and potential effects of several classes of contaminants (e.g., dioxins, dibenzofurans, rodenticides, pharmaceuticals, personal care products, lead shot, and some metals) have not been systematically examined in the past 15 years, highlighting the need for toxicological evaluation of birds found dead, and perhaps an avian ecotoxicological monitoring program. Although oil spills, spent lead shot, some pesticides, and industrial pollutants occasionally harm Chesapeake avifauna, contaminants no longer evoke the population level effects that were observed in Ospreys (Pandion haliaetus) and Bald Eagles (Haliaeetus leucocephalus) through the 1970s.

  12. Distribution of potentially hazardous phases in the subsurface at Yucca Mountain, Nevada

    SciTech Connect

    Guthrie, G.D. Jr.; Bish, D.L.; Chipera, S.J.; Raymond, R. Jr.

    1995-05-01

    Drilling, trenching, excavation of the Exploratory Studies Facility, and other surface and underground-distributing activities have the potential to release minerals into the environment from tuffs at Yucca Mountain, Nevada. Some of these minerals may be potential respiratory health hazards. Therefore, an understanding of the distribution of the minerals that may potentially be liberated during site-characterization and operation of the potential repository is crucial to ensuring worker and public safety. Analysis of previously reported mineralogy of Yucca Mountain tuffs using data and criteria from the International Agency for Research on Cancer (IARC) suggests that the following minerals are of potential concern: quartz, cristobalite, tridymite, opal-CT, erionite, mordenite, and palygorskite. The authors have re-evaluated the three-dimensional mineral distribution at Yucca Mountain above the static water level both in bulk-rock samples and in fractures, using quantitative X-ray powder diffraction analysis. Erionite, mordenite, and palygorskite occur primarily in fractures; the crystalline-silica minerals, quartz, cristobalite, and tridymite are major bulk-rock phases. Erionite occurs in the altered zone just above the lower Topopah Spring Member vitrophyre, and an occurrence below the vitrophyre but above the Calico Hills has recently been identified. In this latter occurrence, erionite is present in the matrix at levels up to 35 wt%. Mordenite and palygorskite occur throughout the vadose zone nearly to the surface. Opal-CT is limited to zeolitic horizons.

  13. The use of total detriment in radiation protection and its potential extension to other hazards

    SciTech Connect

    Johnson, J.R.; Stansbury, P.S.; Selby, J.M.

    1991-10-01

    Before publication of the 1977 recommendations of the International Commission on Radiological Protection (ICRP), radiation protection standards were based on dose limits to single organs. These dose limits were only loosely linked to the expected effects in the first two generations from gonadal doses and to the risk of fatal cancer from doses to specific organs. In 1977, the ICRP recommended the use of the effective dose equivalent (EDE),'' which is a method of summing the doses (weighted with relative risk coefficients) to all organs and tissues, and recommended an annual limit for EDE. Since the 1977 recommendations were published, a total risk'' or total detriment approach has been extended to include nonfatal cancers and genetic effects for all subsequent generations, i.e., the total health detriment from low doses of ionizing radiation. This paper discusses the development of this total health detriment from ionizing radiation exposures, and explores potential methods for using it with other hazards (such as exposures to other physical agents, hazardous chemicals, and fatal and nonfatal accidents) in calculating the total detriment to a worker.

  14. The use of total detriment in radiation protection and its potential extension to other hazards

    SciTech Connect

    Johnson, J.R.; Stansbury, P.S.; Selby, J.M.

    1991-10-01

    Before publication of the 1977 recommendations of the International Commission on Radiological Protection (ICRP), radiation protection standards were based on dose limits to single organs. These dose limits were only loosely linked to the expected effects in the first two generations from gonadal doses and to the risk of fatal cancer from doses to specific organs. In 1977, the ICRP recommended the use of the ``effective dose equivalent (EDE),`` which is a method of summing the doses (weighted with relative risk coefficients) to all organs and tissues, and recommended an annual limit for EDE. Since the 1977 recommendations were published, a ``total risk`` or total detriment approach has been extended to include nonfatal cancers and genetic effects for all subsequent generations, i.e., the total health detriment from low doses of ionizing radiation. This paper discusses the development of this total health detriment from ionizing radiation exposures, and explores potential methods for using it with other hazards (such as exposures to other physical agents, hazardous chemicals, and fatal and nonfatal accidents) in calculating the total detriment to a worker.

  15. Rotational and translational considerations in kinetic impact deflection of potentially hazardous asteroids

    NASA Astrophysics Data System (ADS)

    Zhang, Fei; Xu, Bo; Circi, Christian; Zhang, Lei

    2017-04-01

    Kinetic impact may be the most reliable and easily implemented method to deflect hazardous asteroids using current technology. Depending on warning time, it can be effective on asteroids with diameters of a few hundred meters. Current impact deflection research often focuses on the orbital dynamics of asteroids. In this paper, we use the ejection outcome of a general oblique impact to calculate how an asteroid's rotational and translational state changes after impact. The results demonstrate how small impactors affect the dynamical state of small asteroids having a diameter of about 100 m. According to these consequences, we propose using several small impactors to hit an asteroid continuously and gently, making the deflection mission relatively flexible. After calculating the rotational variation, we find that the rotational state, especially of slender non-porous asteroids, can be changed significantly. This gives the possibility of using multiple small impactors to mitigate a potentially hazardous asteroid by spinning it up into pieces, or to despin one for future in-situ investigation (e.g., asteroid retrieval or mining).

  16. Relationship between the start times of flares and CMEs to the time of potential radiation hazards

    NASA Astrophysics Data System (ADS)

    Kang, G.; Zheng, Y.; Kuznetsova, M. M.

    2013-12-01

    Solar flares, short-term outbursts of energy of the Sun, and coronal mass ejections (CME), massive bursts of solar matter, are two solar phenomena that are known to increase solar energetic particles in space. Increased solar energetic particles cause immense radiation that poses a serious threat to astronauts in space, radio communication signals, and passengers on high-latitude flights on the Earth. The relationship between the start times of flares and CMEs to the time of potential radiation hazards was investigated to determine how much warning time is available. Additionally, this project compared the difference between these relationships for four energy levels of solar energetic particles: proton flux exceeding 10 MeV, 30 MeV, 50 MeV and 100 MeV. This project gathered data of 22 recent SEP events between 2010 and 2012 and the parameters of associated CMEs and flares. Through the use of IDL (Interactive Data Language) programming, thorough analysis was conducted, including 2-sample t-tests and Kruskal-Wallis tests for 2 or more samples. The average lead time to warn humans of possible radiation hazard from the detection of a flare and a CME occurrence was found to be around 12 to 20 hours. The lead time was the greatest for the lowest energy level, though the differences in energy levels and that between the lead times for CME and flares were found to be statistically insignificant with p-values exceeding the alpha value of 0.20.

  17. Evaluation of radiation hazard potential of TENORM waste from oil and natural gas production.

    PubMed

    Hilal, M A; Attallah, M F; Mohamed, Gehan Y; Fayez-Hassan, M

    2014-10-01

    In this study, a potential radiation hazard from TENORM sludge wastes generated during exploration and extraction processes of oil and gas was evaluated. The activity concentration of natural radionuclides (238)U, (226)Ra and (232)Th were determined in TENORM sludge waste. It was found that sludge waste from oil and gas industry is one of the major sources of (226)Ra in the environment. Therefore, some preliminary chemical treatment of sludge waste using Triton X-100 was also investigated to reduce the radioactivity content as well as the risk of radiation hazard from TENORM wastes. The activity concentrations of (226)Ra and (228)Ra in petroleum sludge materials before and after chemical treatment were measured using gamma-ray spectrometry. The average values of the activity concentrations of (226)Ra and (228)Ra measured in the original samples were found as 8908 Bq kg(-1) and 933 Bq kg(-1), respectively. After chemical treatment of TENORM samples, the average values of the activity concentrations of (226)Ra and (228)Ra measured in the samples were found as 7835 Bq kg(-1) and 574 Bq kg(-1), respectively. Activity concentration index, internal index, absorbed gamma dose rate and the corresponding effective dose rate were estimated for untreated and treated samples.

  18. Tsunami hazard assessment in the Ionian Sea due to potential tsunamogenic sources - results from numerical simulations

    NASA Astrophysics Data System (ADS)

    Tselentis, G.-A.; Stavrakakis, G.; Sokos, E.; Gkika, F.; Serpetsidaki, A.

    2010-05-01

    In spite of the fact that the great majority of seismic tsunami is generated in ocean domains, smaller basins like the Ionian Sea sometimes experience this phenomenon. In this investigation, we study the tsunami hazard associated with the Ionian Sea fault system. A scenario-based method is used to provide an estimation of the tsunami hazard in this region for the first time. Realistic faulting parameters related to four probable seismic sources, with tsunami potential, are used to model expected coseismic deformation, which is translated directly to the water surface and used as an initial condition for the tsunami propagation. We calculate tsunami propagation snapshots and mareograms for the four seismic sources in order to estimate the expected values of tsunami maximum amplitudes and arrival times at eleven tourist resorts along the Ionian shorelines. The results indicate that, from the four examined sources, only one possesses a seismic threat causing wave amplitudes up to 4 m at some tourist resorts along the Ionian shoreline.

  19. [War consequences as the potential hazard for the Croatian karst ecosystem].

    PubMed

    Picer, Mladen; Picer, Nena; Calić, Violeta; Hodak Kobasić, Vedranka; Cencic Kodba, Zdenka

    2006-09-01

    In the recent war in Croatia, the karstic area of the country was endangered by hazardous waste, which calls for particular attention because of its exceptional ecological sensitivity. There are strong indications that various organic pollutants have entered the environment. It is also assumed that oil containing polychlorinated biphenyls (PCBs) was spilled in a number of locations. After the penetration in the environment, these substances are quickly absorbed in soil, sediment or bioaccumulated in the organisms of the aquatic ecosystem. In view of the locations of damaged electric transformer stations in Zadar, Bilice and Dubrovnik, there was some speculation on potential hazard posed by organohalogenated toxicants to Lake Vransko and the coastal area around Zadar, Sibenik and Dubrovnik. Samples of sediments and aquatic organisms were collected and analysed, and the results showed no significant or high levels of contaminants in the areas of Lake Vransko, Sibenik, and Dubrovnik (Petka location), while in the Mikulandra Bay near Sibenik, in Rijeka Dubrovacka, Brodanovo location and Marina near the Vruljica Creek in Zadar, significantly higher levels of PCBs were observed and these toxicants were additionally monitored within the APOPSBAL project from 2002 to 2005. The results of these investigations are presented in this paper.

  20. Evaluation of the Potential Optical Radiation Hazards with Led Lamps Intended for Home Use.

    PubMed

    James, Robert H; Landry, Robert J; Walker, Bennett N; Ilev, Ilko K

    2017-01-01

    The authors evaluated the potential for ocular damage from optical radiation emitted by Light Emitting Diode (LED) based lamps used for general illumination. Ten LED lamps were randomly selected off the shelf from a local home improvement store. The LEDs were behind diffusers in half of these lamps, while in the other half, the LEDs were clearly visible. In addition, a battery powered LED lantern having a LED source behind a diffuser was measured. The optical radiation emissions from two common incandescent lamps were also measured to compare the relative hazards of LED and incandescent lamps. All lamp samples were evaluated in accordance with procedures specified in the American National Standards Institute/Illuminating Engineering Society of North America (ANSI/IESNA) Standard RP-27.3. For comparison purposes, the lantern and 100 W incandescent lamps were also evaluated according to ANSI RP-27.1. These measurements indicate that no lamp evaluated poses any photobiological hazard, and therefore, all lamps fall in the RP-27.3 category of Exempt Group. However, when evaluated in accordance with RP-27.1, the 100 W incandescent lamp would be classified in Risk Group 1 (low risk), while the LED lantern would be classified in Risk Group 2 (moderate risk).

  1. Potential environmental hazards of photovoltaic panel disposal: Discussion of Tammaro et al. (2015).

    PubMed

    Sinha, Parikhit

    2017-02-05

    In their recent publication in Journal of Hazardous Materials (http://dx.doi.org/10.1016/j.jhazmat.2015.12.018), Tammaro et al. evaluate the potential environmental impacts of an illegal disposal scenario of photovoltaic panels in the European Union. Critical assumptions that underlie the study's conclusions would benefit from clarification. A scenario of photovoltaic panels finely crushed and abandoned in nature is not supported with field breakage data, in which photovoltaic panels remain largely intact with a number of glass fractures or cracks, as opposed to breakage into cm-scale pieces. Fate and transport analysis is necessary to evaluate how leachate transforms and disperses in moving from the point of emissions to the point of exposure, prior to making comparisons with drinking water limits. Some hazardous metal content has declined in both crystalline silicon and thin film panels, including a 50% decline in semiconductor material intensity in CdTe thin film panels (g CdTe/W) from 2009 to 2015. Waste laws, recycling requirements and minimum treatment standards under the EU WEEE Directive, and illegal disposal rates affect the accuracy of forecasts of releasable metal amounts from PV panels in Europe through 2050. Copyright © 2016 Elsevier B.V. All rights reserved.

  2. Hydro-geomorphic connectivity and landslide features extraction to identifying potential threats and hazardous areas

    NASA Astrophysics Data System (ADS)

    Tarolli, Paolo; Fuller, Ian C.; Basso, Federica; Cavalli, Marco; Sofia, Giulia

    2017-04-01

    Hydro-geomorphic connectivity has significantly emerged as a new concept to understand the transfer of surface water and sediment through landscapes. A further scientific challenge is determining how the concept can be used to enable sustainable land and water management. This research proposes an interesting approach to integrating remote sensing techniques, connectivity theory, and geomorphometry based on high-resolution digital terrain model (HR-DTMs) to automatically extract landslides crowns and gully erosion, to determine the different rate of connectivity among the main extracted features and the river network, and thus determine a possible categorization of hazardous areas. The study takes place in two mountainous regions in the Wellington Region (New Zealand). The methodology is a three step approach. Firstly, we performed an automatic detection of the likely landslides crowns through the use of thresholds obtained by the statistical analysis of the variability of landform curvature. After that, the research considered the Connectivity Index to analyse how a complex and rugged topography induces large variations in erosion and sediment delivery in the two catchments. Lastly, the two methods have been integrated to create a unique procedure able to classify the different rate of connectivity among the main features and the river network and thus identifying potential threats and hazardous areas. The methodology is fast, and it can produce a detailed and updated inventory map that could be a key tool for erosional and sediment delivery hazard mitigation. This fast and simple method can be a useful tool to manage emergencies giving priorities to more failure-prone zones. Furthermore, it could be considered to do a preliminary interpretations of geomorphological phenomena and more in general, it could be the base to develop inventory maps. References Cavalli M, Trevisani S, Comiti F, Marchi L. 2013. Geomorphometric assessment of spatial sediment connectivity

  3. Assessment of the potential respiratory hazard of volcanic ash from future Icelandic eruptions: a study of archived basaltic to rhyolitic ash samples.

    PubMed

    Damby, David E; Horwell, Claire J; Larsen, Gudrun; Thordarson, Thorvaldur; Tomatis, Maura; Fubini, Bice; Donaldson, Ken

    2017-09-11

    The eruptions of Eyjafjallajökull (2010) and Grímsvötn (2011), Iceland, triggered immediate, international consideration of the respiratory health hazard of inhaling volcanic ash, and prompted the need to estimate the potential hazard posed by future eruptions of Iceland's volcanoes to Icelandic and Northern European populations. A physicochemical characterization and toxicological assessment was conducted on a suite of archived ash samples spanning the spectrum of past eruptions (basaltic to rhyolitic magmatic composition) of Icelandic volcanoes following a protocol specifically designed by the International Volcanic Health Hazard Network. Icelandic ash can be of a respirable size (up to 11.3 vol.% < 4 μm), but the samples did not display physicochemical characteristics of pathogenic particulate in terms of composition or morphology. Ash particles were generally angular, being composed of fragmented glass and crystals. Few fiber-like particles were observed, but those present comprised glass or sodium oxides, and are not related to pathogenic natural fibers, like asbestos or fibrous zeolites, thereby limiting concern of associated respiratory diseases. None of the samples contained cristobalite or tridymite, and only one sample contained quartz, minerals of interest due to the potential to cause silicosis. Sample surface areas are low, ranging from 0.4 to 1.6 m(2) g(-1), which aligns with analyses on ash from other eruptions worldwide. All samples generated a low level of hydroxyl radicals (HO(•)), a measure of surface reactivity, through the iron-catalyzed Fenton reaction compared to concurrently analyzed comparative samples. However, radical generation increased after 'refreshing' sample surfaces, indicating that newly erupted samples may display higher reactivity. A composition-dependent range of available surface iron was measured after a 7-day incubation, from 22.5 to 315.7 μmol m(-2), with mafic samples releasing more iron than silicic samples

  4. Kinematics, mechanics, and potential earthquake hazards for faults in Pottawatomie County, Kansas, USA

    USGS Publications Warehouse

    Ohlmacher, G.C.; Berendsen, P.

    2005-01-01

    Many stable continental regions have subregions with poorly defined earthquake hazards. Analysis of minor structures (folds and faults) in these subregions can improve our understanding of the tectonics and earthquake hazards. Detailed structural mapping in Pottawatomie County has revealed a suite consisting of two uplifted blocks aligned along a northeast trend and surrounded by faults. The first uplift is located southwest of the second. The northwest and southeast sides of these uplifts are bounded by northeast-trending right-lateral faults. To the east, both uplifts are bounded by north-trending reverse faults, and the first uplift is bounded by a north-trending high-angle fault to the west. The structural suite occurs above a basement fault that is part of a series of north-northeast-trending faults that delineate the Humboldt Fault Zone of eastern Kansas, an integral part of the Midcontinent Rift System. The favored kinematic model is a contractional stepover (push-up) between echelon strike-slip faults. Mechanical modeling using the boundary element method supports the interpretation of the uplifts as contractional stepovers and indicates that an approximately east-northeast maximum compressive stress trajectory is responsible for the formation of the structural suite. This stress trajectory suggests potential activity during the Laramide Orogeny, which agrees with the age of kimberlite emplacement in adjacent Riley County. The current stress field in Kansas has a N85??W maximum compressive stress trajectory that could potentially produce earthquakes along the basement faults. Several epicenters of seismic events (

  5. IRIS Toxicological Review of Trichloroethylene (TCE) ...

    EPA Pesticide Factsheets

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of Trichloroethylene (TCE) that when finalized will appear on the Integrated Risk Information System (IRIS) database. The purpose of this Toxicological Review is to provide scientific support and rationale for the hazard and dose-response assessment in IRIS pertaining to chronic exposure to trichloroethylene. It is not intended to be a comprehensive treatise on the chemical or toxicological nature of trichloroethylene.

  6. IRIS Toxicological Review of Acrylamide (External Review ...

    EPA Pesticide Factsheets

    EPA has conducted a peer review by EPA’s Science Advisory Board (SAB) of the scientific basis supporting the human health hazard and dose-response assessment of acrylamide that once finalized will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that the science is used credibly and appropriately in derivation of the dose-response assessments and toxicological characterization. The draft Toxicological Review of Acrylamide provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to a chronic exposure to acrylamide.

  7. IRIS Toxicological Review of Acrylamide (External Review ...

    EPA Pesticide Factsheets

    EPA has conducted a peer review by EPA’s Science Advisory Board (SAB) of the scientific basis supporting the human health hazard and dose-response assessment of acrylamide that once finalized will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that the science is used credibly and appropriately in derivation of the dose-response assessments and toxicological characterization. The draft Toxicological Review of Acrylamide provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to a chronic exposure to acrylamide.

  8. Evaluation of high-level nuclear waste tanks having a potential flammable gas hazard

    SciTech Connect

    Johnson, G.D.; Barton, W.B.; Hill, R.C.; et al, Fluor Daniel Hanford

    1997-02-14

    In 1990 the U.S. Department of Energy declared an unreviewed safety question as a result of the behavior of tank 241-SY-101. This tank exhibited episodic releases of flammable gases that on a couple of occasions exceeded the lower flammability limit of hydrogen in air. Over the past six years a considerable amount of knowledge has been gained about the chemical and physical processes that govern the behavior of tank 241-SY-101 and the other tanks associated with a potential flammable gas hazard. This paper presents an overview of the current understanding of gas generation, retention, and release and covers the results of direct sampling of the tanks to determine the gas composition and the amount of stored gas.

  9. Innovation in earthquake and natural hazards research: determining soil liquefaction potential

    SciTech Connect

    Moore, G.B.; Yin, R.K.

    1984-11-01

    This case study analyzes how an innovation in earthquake and natural hazards research was used for practical and policy purposes, why utilization occurred, and what potential policy implications can be drawn. The innovation was the dynamic analysis method, used to identify those soils that are likely to liquefy during earthquakes. The research was designed and undertaken by H. Bolton Seed at the University of California at Berkeley during the 1960s. The research was a major breakthrough in engineering research: liquefaction had never before been reproduced in a laboratory. The work yielded quantitative information about the conditions under which liquefaction occurs. These data were then used to develop procedures for predicting liquefaction; eventually the need to test soil samples in the laboratory was eliminated.

  10. Studies of Short Time Response Options for Potentially Hazardous Objects: Current and Forthcoming Results

    NASA Technical Reports Server (NTRS)

    Barbee, Brent W.; Greenaugh, Kevin C.; Seery, Bernard D.; Bambacus, Myra; Leung, Ronald Y.; Finewood, Lee; Dearborn, David S. P.; Miller, Paul L.; Weaver, Robert P.; Plesko, Catherine; hide

    2017-01-01

    NASA's Goddard Space Flight Center (GSFC) and the National Nuclear Security Administration (NNSA), Department of Energy (DOE) National Laboratories, Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory(LANL), and Sandia National Laboratory (SNL) are collaborating on Planetary Defense Research. The research program is organized around three case studies: 1. Deflection of the Potentially Hazardous Asteroid (PHA) 101955 Bennu (1999 RQ36)[OSIRIS-REx mission target], 2. Deflection of the secondary member of the PHA 65803 Didymos (1996 GT) [DART mission target], 3. Deflection of a scaled-down version of the comet 67PChuryumov-Gerasimenko [Rosetta mission target]. NASAGSFC is providing astrodynamics and spacecraft mission design expertise, while NNSA, DOE, LLNL, LANL and SNL are providing expertise in modeling the effects of kinetic impactor spacecraft and nuclear explosive devices on the target objects.

  11. Regional Seismic Intensity Anomalies in the Korean Peninsula and Its Implications for Seismic-Hazard Potentials

    NASA Astrophysics Data System (ADS)

    Park, Seongjun; Hong, Tae-Kyung

    2017-07-01

    The strength of seismic ground motion is a consequence of seismic source strength and medium response. The dependence of seismic amplitudes and seismic intensity on regional geological structures and crustal properties in the stable intraplate region around the Korean Peninsula is investigated. An instrumental seismic intensity scale based on spectral accelerations are proposed after calibrating with the reported macroseismic intensities. A representative seismic intensity attenuation curve for the Korean Peninsula is given by I(M_{ {L}},l,h) = -0.998 (± 0.222) + 1.72 (± 0.04) M_{ {L}} - 0.322 (± 0.027) {ln}(l^2 + h^2) - 0.00608 (± 0.00049) √{l^2 + h^2}, where I(M_{ {L}},l,h) is the seismic intensity at an epicentral distance l in km for an earthquake with local magnitude M_{ {L}} and focal depth h in km. Seismic intensities decay slowly with distance in the Korean Peninsula. The observed decay rate for the Korean Peninsula is comparable with those for other stable intraplate regions, while are lower than those for active regions. The regional seismic intensity anomalies present a characteristic correlation with geological structures. Positive seismic intensity anomalies appear in the Yeongnam massif, Okcheon belt and Gyeongsang basin, while negative seismic intensity anomalies in the Gyeonggi massif. The regional seismic intensity anomalies display positive correlations with crustal thicknesses, crustal amplifications, and seismicity density and negative correlations with heat flows. Positive seismic intensity anomalies are observed in the Yeongnam massif and Gyeongsang basin, suggesting high seismic-hazard potentials in the regions. The regional crustal properties may provide useful information on potential seismic hazards.

  12. Potential large wood-related hazards at bridges: the Czarny Dunajec River (Poland)

    NASA Astrophysics Data System (ADS)

    Ruiz-Villanueva, Virginia; Wyżga, Bartłomiej; Mikuś, Paweł; Hajdukiewicz, Maciej; Stoffel, Markus

    2016-04-01

    Besides high water levels in the drainage network and important channel changes, the transport of large quantities of wood material must be considered an additional factor of flood hazard in forested areas. At critical sections such as bridges, the effect of the transport and deposition of large quantities of wood during floods is mainly a reduction of the cross-sectional area, triggering a quick succession of backwater effects with inundation of the adjacent valley floor, bed aggradation, channel avulsion and local scouring processes that ultimately may cause embankment/bridge collapse and bank erosion. Therefore, the aim of this work is to analyse potential hazards related to wood transport and deposition in the reach of the Czarny Dunajec (Tatra Mountains foreland, Polish Carpathians) where the river flows through the village of Długopole. Buildings in the village are located very close to the river and the bridge has a very narrow cross-section and is thus threatened by wood-related phenomena. The approach is based on the combination of numerical modelling and field observations. A numerical model which simulates the transport of large wood together with flow dynamics is applied and inlet and boundary conditions are designed based on field observations. We established several scenarios for flow conditions and the wood transport. Results provided data to compute bridge clogging probability under the designed scenarios and the potential impacts of the clogging on hydrodynamics, flooded area and effects on the bridge. This information will be very useful for flood risk assessment and management of the river. This work was supported by the Polish-Swiss FLORIST project (Flood risk on the northern foothills of the Tatra Mountains; PSPB no. 153/2010).

  13. Detection of potentially hazardous convective clouds with a dual-polarized C-band radar

    NASA Astrophysics Data System (ADS)

    Adachi, A.; Kobayashi, T.; Yamauchi, H.; Onogi, S.

    2013-04-01

    A method for forecasting very short-term rainfall to detect potentially hazardous convective cloud that produces heavy local rainfall was developed using actual volumetric C-band polarimetric radar data. Because the rainfall estimation algorithm used in this method removed the effect of ice particles based on polarimetric measurements, it was immune to the high reflectivity associated with hail. The reliability of the algorithm was confirmed by comparing the rainfall rate estimated from the polarimetric radar measurements at the lowest elevation angle with that obtained from an optical disdrometer on the ground. The rainfall rate estimated from polarimetric data agreed well with the results obtained from the disdrometer, and was much more reliable than results derived from reflectivity alone. Two small cumulus cells were analyzed, one of which developed and later produced heavy rainfall, whereas the other did not. Observations made by polarimetric radar with a volumetric scan revealed that a high vertical maximum intensity of rainfall rate and a vertical area of enhanced differential reflectivity extending above the freezing level, often termed a high ZDR column, were clearly formed about 10 min prior to the onset of heavy rainfall on the ground. The onset time of the heavy rainfall could be estimated in advance from the polarimetric data, which agreed fairly well with observations. These polarimetric characteristics were not observed for the cumulus cell that did not produce heavy rainfall. The results suggest that both the vertical maximum intensity of the rainfall rate and a high ZDR column, estimated from polarimetric measurements, can be used to identify potentially hazardous clouds. Furthermore, this study shows that polarimetric radar measurements with high spatial and temporal resolutions are invaluable for disaster reduction.

  14. Detection of potentially hazardous convective clouds with a dual-polarized C-band radar

    NASA Astrophysics Data System (ADS)

    Adachi, A.; Kobayashi, T.; Yamauchi, H.; Onogi, S.

    2013-10-01

    A method for forecasting very short-term rainfall to detect potentially hazardous convective cloud that produces heavy local rainfall was developed using actual volumetric C-band polarimetric radar data. Because the rainfall estimation algorithm used in this method removed the effect of ice particles based on polarimetric measurements, it was immune to the high reflectivity associated with hail. The reliability of the algorithm was confirmed by comparing the rainfall rate estimated from the polarimetric radar measurements at the lowest elevation angle with that obtained from optical disdrometers on the ground. The rainfall rate estimated from polarimetric data agreed well with the results obtained from the disdrometers, and was much more reliable than results derived from reflectivity alone. Two small cumulus cells were analyzed, one of which developed and later produced heavy rainfall, whereas the other did not. Observations made by polarimetric radar with a volumetric scan revealed that a high vertical maximum intensity of rainfall rate and a vertical area of enhanced differential reflectivity extending above the freezing level, often termed a high ZDR column, were clearly formed about 10 min prior to the onset of heavy rainfall on the ground. The onset time of the heavy rainfall could be estimated in advance from the polarimetric data, which agreed fairly well with observations. These polarimetric characteristics were not observed for the cumulus cell that did not produce heavy rainfall. The results suggest that both the vertical maximum intensity of the rainfall rate and a high ZDR column, estimated from polarimetric measurements, can be used to identify potentially hazardous clouds. Furthermore, this study shows that polarimetric radar measurements with high spatial and temporal resolutions are invaluable for disaster reduction.

  15. Presence of Potential Toxin-Producing Cyanobacteria in an Oligo-Mesotrophic Lake in Baltic Lake District, Germany: An Ecological, Genetic and Toxicological Survey

    PubMed Central

    Dadheech, Pawan K.; Selmeczy, Géza B.; Vasas, Gábor; Padisák, Judit; Arp, Wolfgang; Tapolczai, Kálmán; Casper, Peter; Krienitz, Lothar

    2014-01-01

    Massive developments of potentially toxic cyanobacteria in Lake Stechlin, an oligo-mesotrophic lake in the Baltic Lake District of Germany raised concerns about toxic contamination of these important ecosystems. Field samples in the phase of mass developments of cyanobacteria were used for genetic and toxicological analyses. Microcystins and microcystin genes were detected in field samples of the lake for the first time. However, the toxins were not produced by the dominant taxa (Dolichospermum circinale and Aphanizomenon flos-aquae) but by taxa, which were present only in low biomass in the samples (Microcystis cf. aeruginosa and Planktothrix rubescens). The phytoplankton successions during the study period revealed an increase of cyanobacterial populations. The findings contribute to the changes that have been investigated in Lake Stechlin since the mid-1990s. The possible reasons behind these developments may be climate change, special weather conditions and an increased nutrient pool. PMID:25268981

  16. Presence of potential toxin-producing cyanobacteria in an oligo-mesotrophic lake in Baltic Lake District, Germany: an ecological, genetic and toxicological survey.

    PubMed

    Dadheech, Pawan K; Selmeczy, Géza B; Vasas, Gábor; Padisák, Judit; Arp, Wolfgang; Tapolczai, Kálmán; Casper, Peter; Krienitz, Lothar

    2014-09-29

    Massive developments of potentially toxic cyanobacteria in Lake Stechlin, an oligo-mesotrophic lake in the Baltic Lake District of Germany raised concerns about toxic contamination of these important ecosystems. Field samples in the phase of mass developments of cyanobacteria were used for genetic and toxicological analyses. Microcystins and microcystin genes were detected in field samples of the lake for the first time. However, the toxins were not produced by the dominant taxa (Dolichospermum circinale and Aphanizomenon flos-aquae) but by taxa, which were present only in low biomass in the samples (Microcystis cf. aeruginosa and Planktothrix rubescens). The phytoplankton successions during the study period revealed an increase of cyanobacterial populations. The findings contribute to the changes that have been investigated in Lake Stechlin since the mid-1990s. The possible reasons behind these developments may be climate change, special weather conditions and an increased nutrient pool.

  17. Has land subsidence changed the flood hazard potential? A case example from the Kujukuri Plain, Chiba Prefecture, Japan

    NASA Astrophysics Data System (ADS)

    Chen, H. L.; Ito, Y.; Sawamukai, M.; Su, T.; Tokunaga, T.

    2015-11-01

    Coastal areas are subject to flood hazards because of their topographic features, social development and related human activities. The Kujukuri Plain, Chiba Prefecture, Japan, is located nearby the Tokyo metropolitan area and it faces to the Pacific Ocean. In the Kujukuri Plain, widespread occurrence of land subsidence has been caused by exploitation of groundwater, extraction of natural gas dissolved in brine, and natural consolidation of the Holocene and landfill deposits. The locations of land subsidence include areas near the coast, and it may increase the flood hazard potential. Hence, it is very important to evaluate flood hazard potential by taking into account the temporal change of land elevation caused by land subsidence, and to prepare hazard maps for protecting the surface environment and for developing an appropriate land-use plan. In this study, flood hazard assessments at three different times, i.e., 1970, 2004, and 2013 are implemented by using a flood hazard model based on Multicriteria Decision Analysis with Geographical Information System techniques. The model incorporates six factors: elevation, depression area, river system, ratio of impermeable area, detention ponds, and precipitation. Main data sources used are 10 m resolution topography data, airborne laser scanning data, leveling data, Landsat-TM data, two 1:30 000 scale river watershed maps, and precipitation data from observation stations around the study area and Radar data. The hazard assessment maps for each time are obtained by using an algorithm that combines factors with weighted linear combinations. The assignment of the weight/rank values and their analysis are realized by the application of the Analytic Hierarchy Process method. This study is a preliminary work to investigate flood hazards on the Kujukuri Plain. A flood model will be developed to simulate more detailed change of the flood hazard influenced by land subsidence.

  18. A multi-level strategy for anticipating future glacier lake formation and associated hazard potentials

    NASA Astrophysics Data System (ADS)

    Frey, Holger; Haeberli, Wilfried; Huggel, Christian; Linsbauer, Andreas

    2010-05-01

    Due to the expected atmospheric warming, mountain glaciers will retreat, potentially collapse or even vanish completely during the 21st century. When overdeepened parts of the glacier bed are exposed in the course of glacier retreat, glacier lakes can form. Such lakes have a potential for hydropower production, which is an important source of renewable energy. Furthermore they are important elements in the perception of high-mountain landscapes and they can compensate the loss of landscape attractiveness from glacier shrinkage to a certain degree. However, glacier lakes are also a potential source of serious flood and debris flow hazards, especially in densely populated mountain ranges. Thus, methods for early detection of sites with potential lake formation are important for early planning and development of protection concepts. In this contribution we present a multi-scale approach to detect sites with potential future lake formation on four different levels of detail. The methods are developed, tested and - as far as possible - verified in the Swiss Alps; but they can be applied to mountain regions all over the world. On a first level, potential overdeepenings are estimated by selecting flat parts (slope < 5°) of the current glacier surface based on a digital elevation model (DEM) and digital glacier outlines. The same input data are used on the second level for a manual detection of overdeepenings, which are expected at locations where the following three criteria apply: (a) A distinct increase of the glacier surface slope in down-glacier direction; (b) an enlarged width followed by a narrow glacier part; and (c) regions with compressive flow (no crevasses) followed by extending flow (heavily crevassed). On the third level, more sophisticated approaches to model the glacier bed topography are applied to get more quantitative information on potential future lakes. Based on the results of this level, scenarios of future lake outbursts can be modeled with simple

  19. Influence of soil texture on nutrients and potentially hazardous elements in Eremanthus erythropappus.

    PubMed

    Figueiredo, Maurilio Assis; Leite, Mariangela Garcia Praça; Kozovits, Alessandra Rodrigues

    2016-01-01

    Understanding the factors that control uptake rates and allocation of chemical elements among plant organs is a fundamental prerequisite to improve phytostabilization techniques of hazardous elements in contaminated areas. The present study shows evidence that different substrate textures (coarse and fine laterite) do not significantly change the partitioning of root and shoot dry biomass and with few exceptions, do not significantly affect the final average concentration of elements in Eremanthus erythropappus, but change the root:shoot allocation of both essential nutrients and elements potentially toxic to biota. Growth on coarse laterite resulted in significant higher K (30%), Mg (34%), P (25%), S (32%), Cu (58%), and Na (43%) concentrations in roots and lower Cd concentration (29%). In shoots, coarse laterite led to reduction in K, Fe, Al, and Cr and increase in Na and Sr concentrations. Changes in element allocation could be, in part, a result of differences in the water availability of substrates. Matric potential in coarse laterite was significantly lower in at least 47% of the days analyzed throughout the year. Changes in element phytoextraction or phytostabilization potential could influence the efficiency of rehabilitation projects in areas degraded by mining activities.

  20. Quantifying potential tsunami hazard in the Puysegur subduction zone, south of New Zealand

    USGS Publications Warehouse

    Hayes, G.P.; Furlong, K.P.

    2010-01-01

    Studies of subduction zone seismogenesis and tsunami potential, particularly of large subduction zones, have recently seen a resurgence after the great 2004 earthquake and tsunami offshore of Sumatra, yet these global studies have generally neglected the tsunami potential of small subduction zones such as the Puysegur subduction zone, south of New Zealand. Here, we study one such relatively small subduction zone by analysing the historical seismicity over the entire plate boundary region south of New Zealand, using these data to determine the seismic moment deficit of the subduction zone over the past ~100 yr. Our calculations indicate unreleased moment equivalent to a magnitude Mw 8.3 earthquake, suggesting this subduction zone has the potential to host a great, tsunamigenic event. We model this tsunami hazard and find that a tsunami caused by a great earthquake on the Puysegur subduction zone would pose threats to the coasts of southern and western South Island, New Zealand, Tasmania and southeastern Australia, nearly 2000 km distant. No claim to original US government works Geophysical Journal International ?? 2010 RAS.

  1. Advancing adverse outcome pathways for integrated toxicology and regulatory applications

    EPA Science Inventory

    Recent regulatory efforts in many countries have focused on a toxicological pathway-based vision for human health assessments relying on in vitro systems and predictive models to generate the toxicological data needed to evaluate chemical hazard. A pathway-based vision is equally...

  2. IRIS Toxicological Review of Urea (Final Report) | Science ...

    EPA Pesticide Factsheets

    EPA has finalized the Toxicological Review of Urea: in support of the Integrated Risk Information System (IRIS). Now final, this assessment may be used by EPA’s program and regional offices to inform decisions to protect human health. The draft Toxicological Review of Urea provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to Urea.

  3. Advancing adverse outcome pathways for integrated toxicology and regulatory applications

    EPA Science Inventory

    Recent regulatory efforts in many countries have focused on a toxicological pathway-based vision for human health assessments relying on in vitro systems and predictive models to generate the toxicological data needed to evaluate chemical hazard. A pathway-based vision is equally...

  4. Forensic toxicology.

    PubMed

    Drummer, Olaf H

    2010-01-01

    Forensic toxicology has developed as a forensic science in recent years and is now widely used to assist in death investigations, in civil and criminal matters involving drug use, in drugs of abuse testing in correctional settings and custodial medicine, in road and workplace safety, in matters involving environmental pollution, as well as in sports doping. Drugs most commonly targeted include amphetamines, benzodiazepines, cannabis, cocaine and the opiates, but can be any other illicit substance or almost any over-the-counter or prescribed drug, as well as poisons available to the community. The discipline requires high level skills in analytical techniques with a solid knowledge of pharmacology and pharmacokinetics. Modern techniques rely heavily on immunoassay screening analyses and mass spectrometry (MS) for confirmatory analyses using either high-performance liquid chromatography or gas chromatography as the separation technique. Tandem MS has become more and more popular compared to single-stage MS. It is essential that analytical systems are fully validated and fit for the purpose and the assay batches are monitored with quality controls. External proficiency programs monitor both the assay and the personnel performing the work. For a laboratory to perform optimally, it is vital that the circumstances and context of the case are known and the laboratory understands the limitations of the analytical systems used, including drug stability. Drugs and poisons can change concentration postmortem due to poor or unequal quality of blood and other specimens, anaerobic metabolism and redistribution. The latter provides the largest handicap in the interpretation of postmortem results.

  5. Experimental study of the potential hazards of surgical smoke from powered instruments.

    PubMed

    In, S M; Park, D-Y; Sohn, I K; Kim, C-H; Lim, H L; Hong, S-A; Jung, D Y; Jeong, S-Y; Han, J H; Kim, H J

    2015-11-01

    Many surgical instruments have been replaced with powered devices in open gastrointestinal and laparoscopic surgery. The production of smoke as a result of vaporization of surgical tissue is inevitable, and exposure to surgical smoke is a long-standing concern. These vapours are potentially hazardous to patients and surgical teams. The present research was designed to compare various surgical devices to determine whether viable cells exist in their surgical smoke. The search for viable cells in surgical smoke was conducted using both in vitro and in vivo experiments. Various cancers were cauterized with electrocautery, radiofrequency ablation and ultrasonic scalpels, and the resulting surgical smoke was aspirated with Transwell(®) membrane; viable cells were sought in the surgical smoke. In an in vivo experiment, samples of SCC7 were cauterized with an ultrasonic scalpel and the sediment from the rinsed Transwell(®) membrane liquid after centrifugation was injected subcutaneously into the lower back of mice. Viable cells were found only in the smoke from ultrasonic scalpels (in all 25 samples taken 5 cm from the cautery; 2 of 25 samples at 10 cm). Viable cells in the surgical smoke from ultrasonic scalpels implanted in mice grew in 16 of 40 injection sites. Histological and biochemical analyses revealed that these cancer cells were identical to the cancer cells cauterized by the ultrasonic scalpel. Viable tumour cells are produced in the surgical smoke from tumour dissection by ultrasonic scalpel. Surgical relevance Surgical smoke is a byproduct of dissection using a number of powered devices. Hazards to operating room personnel and patients are unclear. This study has shown that use of an ultrasonic dissection device can produce smoke that contains viable tumour cells. Although the model is somewhat artificial, a theoretical risk exists, and measures to evacuate surgical smoke efficiently are important. © 2015 BJS Society Ltd Published by John Wiley & Sons Ltd.

  6. Evaluating and Addressing Potential Hazards of Fuel Tanks Surviving Atmospheric Reentry

    NASA Astrophysics Data System (ADS)

    Kelley, R. L.; Johnson, N. L.

    2012-01-01

    In order to ensure reentering spacecraft do not pose an undue risk to the Earth's population, it is important to design satellites and rocket bodies with end-of-life considerations in mind. In addition to the possible consequences of deorbiting a vehicle, consideration must be given to the possible risks associated with a vehicle failing to become operational or to reach its intended orbit. Based on recovered space debris and numerous reentry survivability analyses, fuel tanks are of particular concern in both of these considerations. Most spacecraft utilize some type of fuel tank as part of their propulsion systems. These fuel tanks are most often constructed using stainless steel or titanium and are filled with potentially hazardous substances such as hydrazine and nitrogen tetroxide. For a vehicle that has reached its scheduled end-of mission, the contents of the tanks are typically depleted. In this scenario, the likely survival of a stainless steel or titanium tank during reentry poses a risk to people and property due to the high melting point and large heat-of-ablation of these materials. If a large portion of the fuel is not depleted prior to reentry, there is the added risk of a hazardous substance being released when the tank impacts the ground. This paper presents a discussion of proactive methods that have been utilized by NASA satellite projects to address the risks associated with fuel tanks reentering the atmosphere. In particular, it will address the design of a demiseable fuel tank, as well as the evaluation of fuel tank designs, which are selected based on whether they burst during reentry.

  7. Potential hazards of toxic metals found in toothpastes commonly used in Nigeria.

    PubMed

    Orisakwe, Orish Ebere; Okolo, Kenneth Obinna; Igweze, Zelinjo Nkeiruka; Ajaezi, Godwin Chukwuebuka; Udowelle, Nnaemeka Arinze

    2016-01-01

    Toothpastes have multi-functional configurations as oral care products. They can however constitute a pos- sible source, amongst others, of toxic metal exposure in public health. Indeed, the public health impact of personal hygiene and consumer products is largely unknown. To determine the level of toxic metals (lead, cadmium, cobalt, chromium, nickel) in toothpastes available in Nigeria, (home produced and imported), and assess the potential risk to the people. The samples of toothpastes commonly used in Nigeria were tested. Using a market basket protocol thirty five different brands of toothpaste were used. Samples were digest by addition of 10 mL mixture of conc. nitric and hydrochloric acids (HCl:HNO(3), 3:1), followed by heating to dryness. 20 mL deionized water was added, stirred and filtered. The filtrate was made up in standard volumetric flask and lead, cadmium, chromium, cobalt and nickel concentrations were determined using the atomic absorption spectrophotometry 205A. The daily intake of metals and target hazard quotient (THQ) were then calculated. Pepsodent and Flodent had the highest levels of lead at respectively 23.575 and 18.092 mg/kg while Colgate Herbal had the highest nickel of 18.535 mg/kg. The daily intake estimates of all imported toothpaste samples were below the stated upper limits (UL). All target hazard quotients were also found to be below one. Although the UL, THQ and daily intake rates were all normal, the high levels of lead in some of the tooth- pastes an important concern to public health suggesting that pre-marketing safety studies of toothpastes may be worthwhile for the regulatory authorities.

  8. Analysis of The Xx Century Effusive Activity At Mount Etna To Assess The Potential Effusive Hazard.

    NASA Astrophysics Data System (ADS)

    Andronico, D.; Lodato, L.; Neri, M.

    We examined older documents and publications together with more recent and de- tailed reports related to the 20th century effusive activity (terminal and flank eruptions) at Mt. Etna, with the primary objective of creating a single data-base of volcanologi- cal data, at present lacking in the literature. The restitution in digital form of the maps of the lava fields allowed to measure, with great precision compared with previous estimations, the area and length of every lava flow, allowing improved estimates of volumes and effusive rates. The quantity and the quality of the collected bibliographic information of the studied eruptions improve progressively from the beginning of the century up to the present, and can be considered complete for the flank activity. The data of each single eruption have been inserted into a relational database, that pro- vides both ease of use and the potential of upgrading with information from new or more ancient eruptions. By examining the collected data (e.g. maximum length of lava flows, altitude reached, eruption duration) we obtained some useful relationships, that allowed us to characterise some eruption typologies at Etna. The improvement of the volcanic data related to the effusive activity of the last century represents an impor- tant contribution in terms of volcanic hazard, suggesting for example the areas most at risk by opening of eruptive fractures and lava covering. Statistical observations can be a useful contribution to the planning required by civil defense in a strongly urban- ized area, such as the etnean one; assessment hazard, in particular, should be focused particularly on the southeastern foot of the volcanic belt, in which the volcanic risk in- creases due to the presence of several populated centers that amount to approximately 500.000 people.

  9. Evaluating and Addressing Potential Hazards of Fuel Tanks Surviving Atmospheric Reentry

    NASA Technical Reports Server (NTRS)

    Kelley, Robert L.; Johnson, Nicholas L.

    2011-01-01

    In order to ensure reentering spacecraft do not pose an undue risk to the Earth's population it is important to design satellites and rocket bodies with end of life considerations in mind. In addition to considering the possible consequences of deorbiting a vehicle, consideration must also be given to the possible risks associated with a vehicle failing to become operational or reach its intended orbit. Based on recovered space debris and numerous reentry survivability analyses, fuel tanks are of particular concern in both of these considerations. Most spacecraft utilize some type of fuel tank as part of their propulsion system. These fuel tanks are most often constructed using stainless steel or titanium and are filled with potentially hazardous substances such as hydrazine and nitrogen tetroxide. For a vehicle which has reached its scheduled end of mission the contents of the tanks are typically depleted. In this scenario the use of stainless steel and titanium results in the tanks posing a risk to people and property do to the high melting point and large heat of ablation of these materials leading to likely survival of the tank during reentry. If a large portion of the fuel is not depleted prior to reentry, there is the added risk of hazardous substance being released when the tank impact the ground. This paper presents a discussion of proactive methods which have been utilized by NASA satellite projects to address the risks associated with fuel tanks reentering the atmosphere. In particular it will address the design of a demiseable fuel tank as well as the evaluation of off the shelf designs which are selected to burst during reentry.

  10. 75 FR 54889 - Development of Set 24 Toxicological Profiles

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-09

    ... ATSDR Web site: http://www.atsdr.cdc.gov/toxpro2.html . Set 24 Toxicological Profiles The following... included on the Priority List of Hazardous Substances ( http://www.atsdr.cdc.gov/cercla/07list.html )....

  11. Innovations in testing strategies in reproductive toxicology.

    PubMed

    Piersma, Aldert H

    2013-01-01

    Toxicological hazard assessment currently finds itself at a crossroads where the existing classical test paradigm is challenged by a host of innovative approaches. Animal study protocols are being enhanced for additional parameters and improved for more efficient effect assessment with reduced animal numbers. Whilst existing testing paradigms have generally proven conservative for chemical safety assessment, novel alternative in silico and in vitro approaches and assays are being introduced that begin to elucidate molecular mechanisms of toxicity. Issues such as animal welfare, alternative assay validation, endocrine disruption, and the US-NAS report on toxicity testing in the twenty-first century have provided directionality to these developments. The reductionistic nature of individual alternative assays requires that they be combined in a testing strategy in order to provide a complete picture of the toxicological profile of a compound. One of the challenges of this innovative approach is the combined interpretation of assay results in terms of toxicologically relevant effects. Computational toxicology aims at providing that integration. In order to progress, we need to follow three steps: (1) Learn from past experience in animal studies and human diseases about critical end points and pathways of toxicity. (2) Design alternative assays for essential mechanisms of toxicity. (3) Build an integrative testing strategy tailored to human hazard assessment using a battery of available alternative tests for critical end points that provides optimal in silico and in vitro filters to upgrade toxicological hazard assessment to the mechanistic level.

  12. Potential public health hazards, exposures and health effects from unconventional natural gas development.

    PubMed

    Adgate, John L; Goldstein, Bernard D; McKenzie, Lisa M

    2014-01-01

    The rapid increase in unconventional natural gas (UNG) development in the United States during the past decade has brought wells and related infrastructure closer to population centers. This review evaluates risks to public health from chemical and nonchemical stressors associated with UNG, describes likely exposure pathways and potential health effects, and identifies major uncertainties to address with future research. The most important occupational stressors include mortality, exposure to hazardous materials and increased risk of industrial accidents. For communities near development and production sites the major stressors are air pollutants, ground and surface water contamination, truck traffic and noise pollution, accidents and malfunctions, and psychosocial stress associated with community change. Despite broad public concern, no comprehensive population-based studies of the public health effects of UNG operations exist. Major uncertainties are the unknown frequency and duration of human exposure, future extent of development, potential emission control and mitigation strategies, and a paucity of baseline data to enable substantive before and after comparisons for affected populations and environmental media. Overall, the current literature suggests that research needs to address these uncertainties before we can reasonably quantify the likelihood of occurrence or magnitude of adverse health effects associated with UNG production in workers and communities.

  13. Map showing potential metal-mine drainage hazards in Colorado, based on mineral-deposit geology

    USGS Publications Warehouse

    Plumlee, Geoffrey S.; Streufert, Randall K.; Smith, Kathleen S.; Smith, Steven M.; Wallace, Alan R.; Toth, Margo I.; Nash, J. Thomas; Robinson, Rob A.; Ficklin, Walter H.; Lee, Gregory K.

    1995-01-01

    This map, compiled by the U.S. Geological Survey (USGS) in cooperation with the Colorado Geological Survey (CGS) and the U. S. Bureau of Land Management (BLM), shows potential mine-drainage hazards that may exist in Colorado metal-mining districts, as indicated by the geologic characteristics of the mineral deposits that occur in the respective districts. It was designed to demonstrate how geologic and geochemical information can be used on a regional scale to help assess the potential for mining-related and natural drainage problems in mining districts, unmined mineralized areas, and surrounding watersheds. The map also provides information on the distribution of different mineral deposit types across Colorado. A GIS (Geographic Information System) format was used to integrate geologic, geochemical, water-quality, climate, landuse, and ecological data from diverse sources. Likely mine-drainage signatures were defined for each mining district based on: (1) a review of the geologic characteristics of the mining district, including mineralogy, trace-element content, host-rock lithology, and wallrock alteration, and; (2) results of site specific studies on the geologic controls on mine-drainage composition.

  14. A multi-level strategy for anticipating future glacier lake formation and associated hazard potentials

    NASA Astrophysics Data System (ADS)

    Frey, H.; Haeberli, W.; Linsbauer, A.; Huggel, C.; Paul, F.

    2010-02-01

    In the course of glacier retreat, new glacier lakes can develop. As such lakes can be a source of natural hazards, strategies for predicting future glacier lake formation are important for an early planning of safety measures. In this article, a multi-level strategy for the identification of overdeepened parts of the glacier beds and, hence, sites with potential future lake formation, is presented. At the first two of the four levels of this strategy, glacier bed overdeepenings are estimated qualitatively and over large regions based on a digital elevation model (DEM) and digital glacier outlines. On level 3, more detailed and laborious models are applied for modeling the glacier bed topography over smaller regions; and on level 4, special situations must be investigated in-situ with detailed measurements such as geophysical soundings. The approaches of the strategy are validated using historical data from Trift Glacier, where a lake formed over the past decade. Scenarios of future glacier lakes are shown for the two test regions Aletsch and Bernina in the Swiss Alps. In the Bernina region, potential future lake outbursts are modeled, using a GIS-based hydrological flow routing model. As shown by a corresponding test, the ASTER GDEM and the SRTM DEM are both suitable to be used within the proposed strategy. Application of this strategy in other mountain regions of the world is therefore possible as well.

  15. Hazard evaluation for 244-AR vault facility

    SciTech Connect

    BRAUN, D.J.

    1999-08-25

    This document presents the results of a hazard identification and evaluation performed on the 244-AR Vault Facility to close a USQ (USQ No.TF-98-0785, Potential Inadequacy in Authorization Basis (PIAB): To Evaluate Miscellaneous Facilities Listed In HNF-2503 And Not Addressed In The TWRS Authorization Basis) that was generated as part of an evaluation of inactive TWRS facilities. A hazard evaluation for the Hanford Site 244-AR Vault Facility was performed. The process and results of the hazard evaluation are provided in this document. A previous hazard evaluation was performed for the 244-AR Vault Facility in 1996 in support of the Basis for Interim Operation (BIO) (HNF-SD-WM-BIO-001, 1998, Revision 1) of the Tank Waste Remediation System (TWRS). The results of that evaluation are provided in the BIO. Upon review of those results it was determined that hazardous conditions that could lead to the release of radiological and toxicological material from the 244-AR vaults due to flooding was not addressed in the original hazards evaluation. This supplemental hazard evaluation addresses this oversight of the original hazard evaluation. The results of the hazard evaluation were compared to the current TWRS BIO to identify any hazardous conditions where Authorization Basis (AB) controls may not be sufficient or may not exist. This document is not part of the AB and is not a vehicle for requesting changes to the AB. It is only intended to provide information about hazardous conditions associated with the condition and configuration of the 244-AR vault facility. The AB Control Decision process could be used to determine the applicability and adequacy of existing AB controls as well as any new controls that may be needed for the identified hazardous conditions associated with 244-AR vault flooding. This hazard evaluation does not constitute an accident analysis.

  16. IRIS Toxicological Review of Trichloroacetic Acid (TCA) ...

    EPA Pesticide Factsheets

    On September 24, 2009, the Toxicological Review of Trichloroacetic Acid (TCA) and the charge to external peer reviewers were released for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Offices before public release. In the new IRIS process, introduced by the EPA Administrator, all written comments on IRIS assessments submitted by other federal agencies and White House Offices will be made publicly available. Accordingly, interagency comments and the interagency science consultation draft of the IRIS Toxicological Review of Trichloroacetic Acid and the charge to external peer reviewers are posted on this site. The draft Toxicological Review of Trichloroacetic Acid provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to trichloroacetic acid.

  17. IRIS Toxicological Review of Formaldehyde (Interagency ...

    EPA Pesticide Factsheets

    On June 2, 2010, the Toxicological Review of Formaldehyde and the charge to external peer reviewers were released for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Offices before public release. In the new IRIS process, introduced by the EPA Administrator, all written comments on IRIS assessments submitted by other federal agencies and White House Offices will be made publicly available. Accordingly, interagency comments and the interagency science consultation draft of the IRIS Toxicological Review of Formaldehyde and the charge to external peer reviewers are posted on this site. The draft Toxicological Review of Formaldehyde-Inhalation Assessment provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic inhalation exposure to formaldehyde.

  18. IRIS Toxicological Review of Urea (Interagency Science ...

    EPA Pesticide Factsheets

    On September 28, 2010, the Toxicological Review of Urea and the charge to external peer reviewers were released for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Offices before public release. In the new IRIS process, introduced by the EPA Administrator, all written comments on IRIS assessments submitted by other federal agencies and White House Offices will be made publicly available. Accordingly, interagency comments and the interagency science consultation draft of the IRIS Toxicological Review of Urea and the charge to external peer reviewers are posted on this site. The draft Toxicological Review of Urea provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to Urea.

  19. Toxicological Benchmarks for Wildlife

    SciTech Connect

    Sample, B.E. Opresko, D.M. Suter, G.W.

    1993-01-01

    Ecological risks of environmental contaminants are evaluated by using a two-tiered process. In the first tier, a screening assessment is performed where concentrations of contaminants in the environment are compared to no observed adverse effects level (NOAEL)-based toxicological benchmarks. These benchmarks represent concentrations of chemicals (i.e., concentrations presumed to be nonhazardous to the biota) in environmental media (water, sediment, soil, food, etc.). While exceedance of these benchmarks does not indicate any particular level or type of risk, concentrations below the benchmarks should not result in significant effects. In practice, when contaminant concentrations in food or water resources are less than these toxicological benchmarks, the contaminants may be excluded from further consideration. However, if the concentration of a contaminant exceeds a benchmark, that contaminant should be retained as a contaminant of potential concern (COPC) and investigated further. The second tier in ecological risk assessment, the baseline ecological risk assessment, may use toxicological benchmarks as part of a weight-of-evidence approach (Suter 1993). Under this approach, based toxicological benchmarks are one of several lines of evidence used to support or refute the presence of ecological effects. Other sources of evidence include media toxicity tests, surveys of biota (abundance and diversity), measures of contaminant body burdens, and biomarkers. This report presents NOAEL- and lowest observed adverse effects level (LOAEL)-based toxicological benchmarks for assessment of effects of 85 chemicals on 9 representative mammalian wildlife species (short-tailed shrew, little brown bat, meadow vole, white-footed mouse, cottontail rabbit, mink, red fox, and whitetail deer) or 11 avian wildlife species (American robin, rough-winged swallow, American woodcock, wild turkey, belted kingfisher, great blue heron, barred owl, barn owl, Cooper's hawk, and red-tailed hawk

  20. Toxicological properties of metaflumizone.

    PubMed

    Hempel, K; Hess, F G; Bögi, C; Fabian, E; Hellwig, J; Fegert, I

    2007-12-15

    Metaflumizone is a new insecticide developed for crop protection and urban pest control by BASF. Its mammalian toxicological profile was assessed by conducting multiple toxicity studies in the rat, mouse, and dog, covering all relevant endpoints. Metaflumizone is characterized by very low acute toxicity, is not irritating to the eye or the skin and does not possess a potential to induce skin sensitization. The substance also shows relatively low toxicity following subchronic oral or dermal exposure to mammals. In addition, metaflumizone demonstrates low toxicological potential following chronic oral exposure to rats, mice, and dogs. Overall, the lowest no observed adverse effect level (NOAEL) is 12mg/(kgday) from the 1-year chronic dog study. In a battery of in vitro and in vivo mutagenicity assays, the weight-of-the-evidence indicates a lack of potential genotoxicity for metaflumizone. Furthermore, the compound demonstrated a lack of potential oncogenicity in long-term toxicity studies in rats and mice. Results from the rat multi-generation reproductive toxicity study as well as the rat and rabbit developmental toxicity studies indicate that metaflumizone is not selectively toxic to the offspring or fetus, as compared to the parents. Also, metaflumizone is not teratogenic in the rat or rabbit. Lastly, no neurotoxicity could be detected in acute and subchronic neurotoxicity studies in rats.

  1. Study of the Effect of Involuntary User Movement on the Potential Light Hazards from Some Ophthalmic Instruments

    NASA Astrophysics Data System (ADS)

    Landry, Robert; Wolffe, Michael; Burrows, Clive; Rassow, Bernhard; Byrnes, Gordon

    2004-03-01

    A study was undertaken to determine whether involuntary user movement provides a basis for relaxing the measurement conditions for evaluating the potential optical radiation hazards to the eye from slit lamps and indirect ophthalmoscopes. This was accomplished by assessment of the extent to which light from these devices can be maintained in focus on a 1-mm-diameter fiber-optic cable for 45 s. The results suggest that, although involuntary user movements can be significant, they do not provide a basis for relaxing the measurement conditions for evaluating the potential optical radiation hazards to the cornea and lens from slit lamps and indirect ophthalmoscopes.

  2. Preliminary hazards analysis for the National Ignition Facility

    SciTech Connect

    Brereton, S.J.

    1993-10-01

    This report documents the Preliminary Hazards Analysis (PHA) for the National Ignition Facility (NIF). In summary, it provides: a general description of the facility and its operation; identification of hazards at the facility; and details of the hazards analysis, including inventories, bounding releases, consequences, and conclusions. As part of the safety analysis procedure set forth by DOE, a PHA must be performed for the NIF. The PHA characterizes the level of intrinsic potential hazard associated with a facility, and provides the basis for hazard classification. The hazard classification determines the level of safety documentation required, and the DOE Order governing the safety analysis. The hazard classification also determines the level of review and approval required for the safety analysis report. The hazards of primary concern associated with NIF are radiological and toxicological in nature. The hazard classification is determined by comparing facility inventories of radionuclides and chemicals with threshold values for the various hazard classification levels and by examining postulated bounding accidents associated with the hazards of greatest significance. Such postulated bounding accidents cannot take into account active mitigative features; they must assume the unmitigated consequences of a release, taking into account only passive safety features. In this way, the intrinsic hazard level of the facility can be ascertained.

  3. IRIS Toxicological Review of n-Butanol (Interagency Science ...

    EPA Pesticide Factsheets

    On September 8, 2011, the Toxicological Review of n-Butanol (External Review Draft) was released for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Offices before public release. In the new IRIS process, introduced by the EPA Administrator, all written comments on IRIS assessments submitted by other federal agencies and White House Offices will be made publicly available. Accordingly, interagency comments with EPA's response and the interagency science consultation draft of the IRIS Toxicological Review of n-Butanol and the charge to external peer reviewers are posted on this site. EPA is undertaking an Integrated Risk Information System (IRIS) health assessment for n-butanol. IRIS is an EPA database containing Agency scientific positions on potential adverse human health effects that may result from chronic (or lifetime) exposure to chemicals in the environment. IRIS contains chemical-specific summaries of qualitative and quantitative health information in support of two steps of the risk assessment paradigm, i.e., hazard identification and dose-response evaluation. IRIS assessments are used in combination with specific situational exposure assessment information to evaluate potential public health risk associated with environmental contaminants.

  4. Biocides in hydraulic fracturing: hazard and vulnerability with respect to potential groundwater pollution

    NASA Astrophysics Data System (ADS)

    Worrall, Fred; Wilson, Miles; Davies, Richard

    2016-04-01

    Biocides are one possible chemical additive to frack fluids and their role is to control bacterial growth. Bacterial growth might lead to biofilm build up; and acid sulfide species and hydrogen sulfide (H2S) production: biofilm build up may reduce formation permeability and hinder gas extraction. Kahrilas et al. (2014) published a review of common biocides used in fracking in the USA. The biocides assessed in the review were the sixteen most commonly used in the USA, based on the hydraulic fracturing chemical registry Frac Focus (Frac Focus, 2015). However, the review of Kahrilas et al. (2014) contained no data or observations and so the objective of this study was to consider whether biocides proposed for use in hydrofacturing could be a threat to English groundwater. The study considered all groundwater samples analysed for biocides in English groundwater between 2005 and 2014. The monitoring records were compared to: records of application (both amount and area); and chemical and molecular data for the biocides. The study did not use traditional adsorption and degradation data as these parameters are to prone to variability and are not pure molecular parameters. The study then used the approach of Worrall and Thomsen (2004) to consider the hazard represented by proposed frack biocides and the approach of Worrall and Kolpin (2003) to consider the vulnerability of the areas of potential shale gas exploitation. The study showed that of the 113 biocides tested for in English groundwaters in the decade 2005 - 2014 that 95 were detected above 0.1 g/l . Of these 95, 41 were compounds that were not recorded as being applied during the period of record and the detection of these 41 compounds did not decline over the 10 year period which implies very long residence times and that once compounds do pollute an aquifer then they will be a persistent problem. Furthermore, the solubility of the range of biocides used in frack fluids would imply a potentially higher hazard

  5. Tsunami hazard potential for the equatorial southwestern Pacific atolls of Tokelau from scenario-based simulations

    NASA Astrophysics Data System (ADS)

    Orpin, Alan R.; Rickard, Graham J.; Gerring, Peter K.; Lamarche, Geoffroy

    2016-05-01

    Devastating tsunami over the last decade have significantly heightened awareness of the potential consequences and vulnerability of low-lying Pacific islands and coastal regions. Our appraisal of the potential tsunami hazard for the atolls of the Tokelau Islands is based on a tsunami source-propagation-inundation model using Gerris Flow Solver, adapted from the companion study by Lamarche et al. (2015) for the islands of Wallis and Futuna. We assess whether there is potential for tsunami flooding on any of the village islets from a selection of 14 earthquake-source experiments. These earthquake sources are primarily based on the largest Pacific earthquakes of Mw ≥ 8.1 since 1950 and other large credible sources of tsunami that may impact Tokelau. Earthquake-source location and moment magnitude are related to tsunami-wave amplitudes and tsunami flood depths simulated for each of the three atolls of Tokelau. This approach yields instructive results for a community advisory but is not intended to be fully deterministic. Rather, the underlying aim is to identify credible sources that present the greatest potential to trigger an emergency response. Results from our modelling show that wave fields are channelled by the bathymetry of the Pacific basin in such a way that the swathes of the highest waves sweep immediately northeast of the Tokelau Islands. Our limited simulations suggest that trans-Pacific tsunami from distant earthquake sources to the north of Tokelau pose the most significant inundation threat. In particular, our assumed worst-case scenario for the Kuril Trench generated maximum modelled-wave amplitudes in excess of 1 m, which may last a few hours and include several wave trains. Other sources can impact specific sectors of the atolls, particularly distant earthquakes from Chile and Peru, and regional earthquake sources to the south. Flooding is dependent on the wave orientation and direct alignment to the incoming tsunami. Our "worst-case" tsunami

  6. IRIS Toxicological Review of Tetrachloroethylene ...

    EPA Pesticide Factsheets

    EPA conducted a peer review of the scientific basis supporting the human health hazard and dose-response assessment of tetrachloroethylene that will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that science is used credibly and appropriately in derivation of the toxicological characterization and dose-response assessments. This draft health assessment addresses both non-cancer and cancer human health effects that may result from chronic exposure to tetrachloroethylene (also called Perchloroethylene or Perc) . This is an update of an existing assessment posted on IRIS in 1988. This draft Toxicological Review includes a chronic Reference Concentration (RfC) and carcinogenicity assessment, which are not currently available on IRIS, as well as an update of the 1988 IRIS Reference Dose (RfD). Tetrachloroethylene is a chemical solvent that is widely used for dry cleaning of fabrics, metal degreasing, and in making some consumer products and other chemicals.

  7. IRIS Toxicological Review of Tetrachloroethylene ...

    EPA Pesticide Factsheets

    EPA conducted a peer review of the scientific basis supporting the human health hazard and dose-response assessment of tetrachloroethylene that will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that science is used credibly and appropriately in derivation of the toxicological characterization and dose-response assessments. This draft health assessment addresses both non-cancer and cancer human health effects that may result from chronic exposure to tetrachloroethylene (also called Perchloroethylene or Perc) . This is an update of an existing assessment posted on IRIS in 1988. This draft Toxicological Review includes a chronic Reference Concentration (RfC) and carcinogenicity assessment, which are not currently available on IRIS, as well as an update of the 1988 IRIS Reference Dose (RfD). Tetrachloroethylene is a chemical solvent that is widely used for dry cleaning of fabrics, metal degreasing, and in making some consumer products and other chemicals.

  8. Potential biomass and logs from fire-hazard-reduction treatments in Southwest Oregon and Northern California

    Treesearch

    R. James Barbour; Jeremy Fried; Peter J. Daugherty; Glenn Christensen; Roger. Fight

    2008-01-01

    The FIA BioSum model was used to simulate three fire-hazard-reduction policies in an area comprising northern California, southwestern Oregon, and the east slopes of the Cascade Mountains in Oregon. The policy scenarios, all subject to a stand-scale fire-hazard-reduction effectiveness constraint, included maximize torching index improvement (Max TI), maximize net...

  9. IRIS Toxicological Review of Trichloroacetic Acid (TCA) ...

    EPA Pesticide Factsheets

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of Trichloroacetic acid (TCA) that when finalized will appear on the Integrated Risk Information System (IRIS) database. The draft Toxicological Review of trichloroacetic acid provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to trichloroacetic acid.

  10. Biomarkers in Computational Toxicology

    EPA Science Inventory

    Biomarkers are a means to evaluate chemical exposure and/or the subsequent impacts on toxicity pathways that lead to adverse health outcomes. Computational toxicology can integrate biomarker data with knowledge of exposure, chemistry, biology, pharmacokinetics, toxicology, and e...

  11. Biomarkers in Computational Toxicology

    EPA Science Inventory

    Biomarkers are a means to evaluate chemical exposure and/or the subsequent impacts on toxicity pathways that lead to adverse health outcomes. Computational toxicology can integrate biomarker data with knowledge of exposure, chemistry, biology, pharmacokinetics, toxicology, and e...

  12. IRIS Toxicological Review of Chloroprene (Final Report)

    EPA Science Inventory

    The final Toxicological Review of Chloroprene provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to chloroprene. Chloroprene (C4H5Cl) is a volatile, flammable liquid used primarily in the manufacture of poly...

  13. IRIS Toxicological Review of Chloroprene (Final Report)

    EPA Science Inventory

    The final Toxicological Review of Chloroprene provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to chloroprene. Chloroprene (C4H5Cl) is a volatile, flammable liquid used primarily in the manufacture of poly...

  14. Translational toxicology in setting occupational exposure limits for dusts and hazard classification - a critical evaluation of a recent approach to translate dust overload findings from rats to humans.

    PubMed

    Morfeld, Peter; Bruch, Joachim; Levy, Len; Ngiewih, Yufanyi; Chaudhuri, Ishrat; Muranko, Henry J; Myerson, Ross; McCunney, Robert J

    2015-04-23

    We analyze the scientific basis and methodology used by the German MAK Commission in their recommendations for exposure limits and carcinogen classification of "granular biopersistent particles without known specific toxicity" (GBS). These recommendations are under review at the European Union level. We examine the scientific assumptions in an attempt to reproduce the results. MAK's human equivalent concentrations (HECs) are based on a particle mass and on a volumetric model in which results from rat inhalation studies are translated to derive occupational exposure limits (OELs) and a carcinogen classification. We followed the methods as proposed by the MAK Commission and Pauluhn 2011. We also examined key assumptions in the metrics, such as surface area of the human lung, deposition fractions of inhaled dusts, human clearance rates; and risk of lung cancer among workers, presumed to have some potential for lung overload, the physiological condition in rats associated with an increase in lung cancer risk. The MAK recommendations on exposure limits for GBS have numerous incorrect assumptions that adversely affect the final results. The procedures to derive the respirable occupational exposure limit (OEL) could not be reproduced, a finding raising considerable scientific uncertainty about the reliability of the recommendations. Moreover, the scientific basis of using the rat model is confounded by the fact that rats and humans show different cellular responses to inhaled particles as demonstrated by bronchoalveolar lavage (BAL) studies in both species. Classifying all GBS as carcinogenic to humans based on rat inhalation studies in which lung overload leads to chronic inflammation and cancer is inappropriate. Studies of workers, who have been exposed to relevant levels of dust, have not indicated an increase in lung cancer risk. Using the methods proposed by the MAK, we were unable to reproduce the OEL for GBS recommended by the Commission, but identified substantial

  15. Modes of occurrence of potentially hazardous elements in coal: levels of confidence

    USGS Publications Warehouse

    Finkelman, R.B.

    1994-01-01

    The modes of occurrence of the potentially hazardous elements in coal will be of significance in any attempt to reduce their mobilization due to coal combustion. Antimony and selenium may be present in solid solution in pyrite, as minute accessory sulfides dispersed throughout the organic matrix, or in organic association. Because of these modes of occurrence it is anticipated that less than 50% of these elements will be routinely removed by conventional coal cleaning procedures. Arsenic and mercury occur primarily in late-stage coarse-grained pyrite therefore physical coal cleaning procedures should be successful in removing substantial proportions of these elements. Cadmium occurs in sphalerite and lead in galena. Both of these minerals exhibit a wide range of particle sizes and textural relations. Depending on the particle size and textural relations, physical coal cleaning may remove as little as 25% of these elements or as much as 75%. Manganese in bituminous coal occurs in carbonates, especially siderite. Physical coal cleaning should remove a substantial proportion of this element. More information is needed to elucidate the modes of occurrence of beryllium, chromium, cobalt, and nickel. ?? 1994.

  16. Potentially hazardous elements in coal: Modes of occurrence and summary of concentration data for coal components

    USGS Publications Warehouse

    Kolker, A.; Finkelman, R.B.

    1998-01-01

    Mode-of-occurrence data are summarized for 13 potentially hazardous elements (Be, Cr, Mn, Co, Ni, As, Se, Cd, Sb, Hg, Pb, Th, U) in coal. Recent work has refined mode-of-occurrence data for Ni, Cr, and As, as compared to previous summaries. For Cr, dominant modes of occurrence include the clay mineral illite, an amorphous CrO(OH) phase, and Cr-bearing spinels. Nickel is present in Fe-sulfides (pyrite and marcasite) and is also organically bound. Arsenic-bearing pyrite may be the dominant host of As in bituminous coals. Concentration data for the 13 HAPs, obtained primarily by quantitative microanalysis techniques, are compiled for mineral and organic portions of coal. HAPs element concentrations are greatest in Fe-sulfides, and include maxima of 2,300 ppm (Co), 4,500 ppm (Ni), 4.9wt.% (As), 2,000 ppm (Se), 171 ppm (Hg), and 5,500 ppm (Pb). Trace-element microanalysis is a significant refinement over bulk methods, and shows that there is considerable trace-element variation on a fine scale for a given coal, and from one coal to another. ?? 1998 OPA (Overseas Publishers Association) N.V. Published by license under the Gordon and Breach Science Publishers imprint.

  17. Microbiological profile and potential hazards associated with imported and local brands of tomato paste in Nigeria.

    PubMed

    Efiuvwevwere, B J; Atirike, O I

    1998-03-01

    Cans of three tomato paste brands (two of which are imported and one produced locally) showing defective or normal appearance were purchased from various retail outlets and analysed for microbial composition and pH values. Substantially higher total viable counts were observed in samples from defective cans but the lowest population was found in the local brand. Ratio of mesophilic to thermophilic micro-organisms increased in samples obtained from cans showing visible defects. Anaerobic spore counts were higher than the aerobic population in both normal and defective cans, but the counts varied with the brands. Four dominant bacterial genera (Bacillus, Clostridium, Lactobacillus and Leuconostoc) were isolated from the samples with the greater proportion being spore-formers. Percentage occurrence of Clostridium thermosaccharolyticum was appreciably higher in samples from defective cans while a preponderance of Lactobacillus occurred in samples from normal cans. Of the moulds isolated, Absidia and Aspergillus fumigatus showed a higher percentage in defective cans. pH values higher than the critical safe level of 4.6 were found in cans with visible defects and greater microbial diversity with higher microbial load was more often associated with these samples. Imported brands showed more undesirable microbial quality and pH values, making them potentially hazardous.

  18. Observations of the potentially hazardous asteroid 275677 and the modeling of its shape

    NASA Astrophysics Data System (ADS)

    Karavaev, Yu. S.

    2015-07-01

    Knowledge of the physical properties of asteroids is required in order to calculate the evolution of their orbits under the influence of nongravitational effects. Photometric observations of the potentially hazardous asteroid 275677 were conducted at the Sayan Solar Observatory of the Institute of Solar-Terrestrial Physics from March 25, 2014, through April 4, 2014 (at the time when this asteroid approached Earth). The period of rotation of the asteroid about its center of mass and the light curve, which defines the phase dependence of its brightness in a single rotation period, were determined based on the results of measurements performed by the Lafler-Kinman method. A model was constructed based on the obtained light curve. When this model was rotated, the variable component of the reflected radiation in a single revolution matched the variable component of the light curve of the asteroid. The range of possible directions of the axis of rotation of the asteroid was determined in the process of modeling.

  19. Household hazardous wastes as a potential source of pollution: a generation study.

    PubMed

    Ojeda-Benítez, Sara; Aguilar-Virgen, Quetzalli; Taboada-González, Paul; Cruz-Sotelo, Samantha E

    2013-12-01

    Certain domestic wastes exhibit characteristics that render them dangerous, such as explosiveness, flammability, spontaneous combustion, reactivity, toxicity and corrosiveness. The lack of information about their generation and composition hinders the creation of special programs for their collection and treatment, making these wastes a potential threat to human health and the environment. We attempted to quantify the levels of hazardous household waste (HHW) generated in Mexicali, Mexico. The analysis considered three socioeconomic strata and eight categories. The sampling was undertaken on a house-by-house basis, and hypothesis testing was based on differences between two proportions for each of the eight categories. In this study, HHW comprised 3.49% of the total generated waste, which exceeded that reported in previous studies in Mexico. The greatest quantity of HHW was generated by the middle stratum; in the upper stratum, most packages were discarded with their contents remaining. Cleaning products represent 45.86% of the HHW generated. Statistical differences were not observed for only two categories among the three social strata. The scarcity of studies on HHW generation limits direct comparisons. Any decrease in waste generation within the middle social stratum will have a large effect on the total amount of waste generated, and decrease their impact on environmental and human health.

  20. Assessment of DSN Communication Coverage for Space Missions to Potentially Hazardous Asteroids

    NASA Technical Reports Server (NTRS)

    Kegege, Obadiah; Bittner, David; Gati, Frank; Bhasin, Kul

    2012-01-01

    A communication coverage gap exists for Deep Space Network (DSN) antennas. This communication coverage gap is on the southern hemisphere, centered at approximate latitude of -47deg and longitude of -45deg. The area of this communication gap varies depending on the altitude from the Earth s surface. There are no current planetary space missions that fall within the DSN communication gap because planetary bodies in the Solar system lie near the ecliptic plane. However, some asteroids orbits are not confined to the ecliptic plane. In recent years, Potentially Hazardous Asteroids (PHAs) have passed within 100,000 km of the Earth. NASA s future space exploration goals include a manned mission to asteroids. It is important to ensure reliable and redundant communication coverage/capabilities for manned space missions to dangerous asteroids that make a sequence of close Earth encounters. In this paper, we will describe simulations performed to determine whether near-Earth objects (NEO) that have been classified as PHAs fall within the DSN communication coverage gap. In the study, we reviewed literature for a number of PHAs, generated binary ephemeris for selected PHAs using JPL s HORIZONS tool, and created their trajectories using Satellite Took Kit (STK). The results show that some of the PHAs fall within DSN communication coverage gap. This paper presents the simulation results and our analyses

  1. White Paper on Potential Hazards Associated with Contaminated Cheesecloth Exposed to Nitric Acid Solutions

    SciTech Connect

    Hypes, Philip A.

    2016-09-20

    This white paper addresses the potential hazards associated with waste cheesecloth that has been exposed to nitric acid solutions. This issue was highlighted by the cleanup of a 100 ml leak of aqueous nitric acid solution containing Heat Source (HS) plutonium on 21 June 2016. Nitration of cellulosic material is a well-understood process due to industrial/military applications of the resulting material. Within the Department of Energy complex, nitric acids have been used extensively, as have cellulosic wipes. If cellulosic materials are nitrated, the cellulosic material can become ignitable and in extreme cases, reactive. We have chemistry knowledge and operating experience to support the conclusion that all current wastes are safe and compliant. There are technical questions worthy of further experimental evaluation. An extent of condition evaluation has been conducted back to 2004. During this time period there have been interruptions in the authorization to use cellulosic wipes in PF-4. Limited use has been authorized since 2007 (for purposes other than spill cleanup), so our extent of condition includes the entire current span of use. Our evaluation shows that there is no indication that process spills involving high molarity nitric acid were cleaned up with cheesecloth since 2007. The materials generated in the 21 June leak will be managed in a safe manner compliant with all applicable requirements.

  2. Screening strategy to avoid toxicological hazards of inhaled nanoparticles for drug delivery: The use of a-quartz and nano zinc oxide particles as benchmark

    NASA Astrophysics Data System (ADS)

    Beyerle, Andrea; Schulz, Holger; Kissel, Thomas; Stoeger, Tobias

    2009-02-01

    Nanotechnology is a broad, revolutionary field with promising advantages for new medicine. In this context the rapid development and improvement of so called nanocarriers is of high pharmaceutical interest and some devices are already on the market. In our project we aim to develop well characterized nanoscaled drug delivery systems for an inhalative application. To this end, we focus on the most adverse side-effects within the lung, the cytotoxic and the proinflammatory responses to these nanoparticles (NPs). Before performing any animal experiments, we start with an in vitro screening for analyzing the cytotoxic and proinflammatory effects of the investigated particles on two murine lung target cell lines, the alveolar epithelial like typ II cell line (LA4) and the alveolar macrophage cell line (MH-S). Three different endpoints were estimated, (i) cellular metabolic activity, determined by the WST-1 assay, (ii) membrane integrity, by detection of LDH release and hemolytic activity, and (iii) secretion of inflammatory mediators. To analyze the relative particle toxicity we choose two reference particles as benchmarks, (i) fine a-quartz, and (ii) ultrafine ZnO particles. The investigation of dose-response and kinetics of proinflammatory and toxic effects caused to the named cell lines provide an insight to a close evaluation of our cell based screening strategy. oc-quartz is well known for its inflammatory and toxic potential caused by inhalation, and nanosized ZnO particles - used in a broad field of nanotechnology like electronics, but also cosmetics and pharmaceuticals - is to a high degree cytotoxic and proinflammatory in vitro. Preliminary experiments indicated not only particle and cell specific inflammatory responses, but also different susceptibilities of the cell types being exposed to our benchmark particles regarding their size and surface activities. Exposure to the μm-sized a-quartz particles affected the viability of epithelia cells less than that of

  3. Potentially Hazardous Co-orbiting Materials of Asteroid 138175 Identified by Interplanetary Field Enhancements

    NASA Astrophysics Data System (ADS)

    Lai, Hairong; Russell, Christopher; Wei, Hanying; Delzanno, Gian Luca; Connors, Martin

    2014-05-01

    potentially hazardous NEO list, its co-orbiting materials may have high impact probability and cause significant damage due to their dispersed orbits and non-negligible size range. The same technique can be applied to the remaining thousands of known NEOs crossing the ecliptic plane inside the Earth's orbit and find those that have co-orbiting materials which might be hazardous to the Earth. Thus alerts can be issued when the Earth approaches the orbits of objects with co-orbiting debris.

  4. Quantifying potential earthquake and tsunami hazard in the Lesser Antilles subduction zone of the Caribbean region

    USGS Publications Warehouse

    Hayes, Gavin P.; McNamara, Daniel E.; Seidman, Lily; Roger, Jean

    2013-01-01

    In this study, we quantify the seismic and tsunami hazard in the Lesser Antilles subduction zone, focusing on the plate interface offshore of Guadeloupe. We compare potential strain accumulated via GPS-derived plate motions to strain release due to earthquakes that have occurred over the past 110 yr, and compute the resulting moment deficit. Our results suggest that enough strain is currently stored in the seismogenic zone of the Lesser Antilles subduction arc in the region of Guadeloupe to cause a large and damaging earthquake of magnitude Mw ∼ 8.2 ± 0.4. We model several scenario earthquakes over this magnitude range, using a variety of earthquake magnitudes and rupture areas, and utilizing the USGS ShakeMap and PAGER software packages. Strong ground shaking during the earthquake will likely cause loss of life and damage estimated to be in the range of several tens to several hundreds of fatalities and hundreds of millions to potentially billions of U.S. dollars of damage. In addition, such an event could produce a significant tsunami. Modelled tsunamis resulting from these scenario earthquakes predict meter-scale wave amplitudes even for events at the lower end of our magnitude range (M 7.8), and heights of over 3 m in several locations with our favoured scenario (M 8.0, partially locked interface from 15–45 km depth). In all scenarios, only short lead-times (on the order of tens of minutes) would be possible in the Caribbean before the arrival of damaging waves.

  5. Marine and land active-source seismic investigation of geothermal potential, tectonic structure, and earthquake hazards in Pyramid Lake, Nevada

    SciTech Connect

    Eisses, A.; Kell, A.; Kent, G.; Driscoll, N.; Karlin, R.; Baskin, R.; Louie, J.; Pullammanappallil, S.

    2016-08-01

    Amy Eisses, Annie M. Kell, Graham Kent, Neal W. Driscoll, Robert E. Karlin, Robert L. Baskin, John N. Louie, Kenneth D. Smith, Sathish Pullammanappallil, 2011, Marine and land active-source seismic investigation of geothermal potential, tectonic structure, and earthquake hazards in Pyramid Lake, Nevada: presented at American Geophysical Union Fall Meeting, San Francisco, Dec. 5-9, abstract NS14A-08.

  6. Thinning and prescribed fire and projected trends in wood product potential, financial return, and fire hazard in Montana.

    Treesearch

    R. James Barbour; Roger D. Fight; Glenn A. Christensen; Guy L. Pinjuv; Rao V. Nagubadi

    2004-01-01

    This work was undertaken under a joint fire science project "Assessing the need, costs, and potential benefits of prescribed fire and mechanical treatments to reduce fire hazard." This paper compares the future mix of timber products under two treatment scenarios for the state of Montana. We developed and demonstrated an analytical method that uses readily...

  7. Thinning and prescribed fire and projected trends in wood product potential, financial return, and fire hazard in New Mexico.

    Treesearch

    Roger D. Fight; R. James Barbour; Glenn Christensen; Guy L. Pinjuv; Rao V. Nagubadi

    2004-01-01

    This work was undertaken under a joint fire science project "Assessing the need, costs, and potential benefits of prescribed fire and mechanical treatments to reduce fire hazard." This paper compares the future mix of timber projects under two treatment scenarios for New Mexico.We developed and demonstrated an analytical method that uses readily available...

  8. Potential postwildfire debris-flow hazards - A prewildfire evaluation for the Jemez Mountains, north-central New Mexico

    Treesearch

    Anne C. Tillery; Jessica Haas

    2016-01-01

    Wildfire can substantially increase the probability of debris flows, a potentially hazardous and destructive form of mass wasting, in landscapes that have otherwise been stable throughout recent history. Although the exact location, extent, and severity of wildfire or subsequent rainfall intensity and duration cannot be known, probabilities of fire and debris‑flow...

  9. Portable medical status system. [potential hazards in the use of the telecare system

    NASA Technical Reports Server (NTRS)

    Lindsey, O. C.

    1976-01-01

    The hazards inherent in the Portable Medical Status System are identified, and the measures taken to reduce them to an acceptable level are described. Identification of these hazards is a prerequisite to use of the system on humans in the earth environment. One hazard which is insufficiently controlled and which is considered a constraint to use on humans is the level of current possible in the electrodes for the EEG (electroencephalograph) circuitry. It exceeds the maximum specified. A number of procedural and design recommendations for enhancement of safety are made.

  10. Distribution, sources, and potential toxicological significance of PAHs in drinking water sources within the Pearl River Delta.

    PubMed

    An, Taicheng; Qiao, Meng; Li, Guiying; Sun, Hongwei; Zeng, Xiangying; Fu, Jiamo

    2011-05-01

    The Pearl River Delta (PRD) region is one of the most population-dense areas in China. The safety of its drinking source water is essential to human health. Polycyclic aromatic hydrocarbons (PAHs) have attracted attention from the scientific community and the general public due to their toxicity and wide distribution in the global environment. In this work, PAHs pollution levels from the drinking source water in nine main cities within the PRD were investigated. ∑15 PAHs concentrations during the wet season varied from 32.0 to 754.8 ng L(-1) in the dissolved phase, and from 13.4 to 3017.8 ng L(-1) in the particulate phase. During the dry season, dissolved PAHs ranged from 48.1 to 113.6 ng L(-1), and particulate PAHs from 8.6 to 69.6 ng L(-1). Overall, ∑15 PAHs concentrations were extremely high in the XC and ZHQ stations during the wet season in 2008 and 2009. In most sites, PAHs originated from mixed sources. Hazard ratios based on non-cancerous and cancerous risks were extremely higher in XC compared with the others during the wet season, though they were much less than 1. Nevertheless, risks caused by the combined toxicity of ∑15 PAHs and other organics should be seriously considered. PAHs toxic equivalent quantities ranged from 0.508 to 177.077 ng L(-1).

  11. Public Databases Supporting Computational Toxicology

    EPA Science Inventory

    A major goal of the emerging field of computational toxicology is the development of screening-level models that predict potential toxicity of chemicals from a combination of mechanistic in vitro assay data and chemical structure descriptors. In order to build these models, resea...

  12. Public Databases Supporting Computational Toxicology

    EPA Science Inventory

    A major goal of the emerging field of computational toxicology is the development of screening-level models that predict potential toxicity of chemicals from a combination of mechanistic in vitro assay data and chemical structure descriptors. In order to build these models, resea...

  13. Nanotechnology: Toxicologic Pathology

    PubMed Central

    Hubbs, Ann F.; Sargent, Linda M.; Porter, Dale W.; Sager, Tina M.; Chen, Bean T.; Frazer, David G.; Castranova, Vincent; Sriram, Krishnan; Nurkiewicz, Timothy R.; Reynolds, Steven H.; Battelli, Lori A.; Schwegler-Berry, Diane; McKinney, Walter; Fluharty, Kara L.; Mercer, Robert R.

    2015-01-01

    Nanotechnology involves technology, science, and engineering in dimensions less than 100 nm. A virtually infinite number of potential nanoscale products can be produced from many different molecules and their combinations. The exponentially increasing number of nanoscale products will solve critical needs in engineering, science, and medicine. However, the virtually infinite number of potential nanotechnology products is a challenge for toxicologic pathologists. Because of their size, nanoparticulates can have therapeutic and toxic effects distinct from micron-sized particulates of the same composition. In the nanoscale, distinct intercellular and intracellular translocation pathways may provide a different distribution than that obtained by micron-sized particulates. Nanoparticulates interact with subcellular structures including microtubules, actin filaments, centrosomes, and chromatin; interactions that may be facilitated in the nanoscale. Features that distinguish nanoparticulates from fine particulates include increased surface area per unit mass and quantum effects. In addition, some nanotechnology products, including the fullerenes, have a novel and reactive surface. Augmented microscopic procedures including enhanced dark-field imaging, immunofluorescence, field-emission scanning electron microscopy, transmission electron microscopy, and confocal microscopy are useful when evaluating nanoparticulate toxicologic pathology. Thus, the pathology assessment is facilitated by understanding the unique features at the nanoscale and the tools that can assist in evaluating nanotoxicology studies. PMID:23389777

  14. Burnout in Counseling Practice: Some Potential Professional and Personal Hazards of Becoming a Counselor.

    ERIC Educational Resources Information Center

    Watkins, C. Edward, Jr.

    1983-01-01

    Defines the syndrome of burnout and discusses some of the professional and personal hazards that confront the practicing counselor. Examines intrapersonal and interpersonal difficulties which result from burnout. Provides suggestions for dealing with burnout. (Author/RC)

  15. Burnout in Counseling Practice: Some Potential Professional and Personal Hazards of Becoming a Counselor.

    ERIC Educational Resources Information Center

    Watkins, C. Edward, Jr.

    1983-01-01

    Defines the syndrome of burnout and discusses some of the professional and personal hazards that confront the practicing counselor. Examines intrapersonal and interpersonal difficulties which result from burnout. Provides suggestions for dealing with burnout. (Author/RC)

  16. IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (Etbe) ...

    EPA Pesticide Factsheets

    In September 2016, EPA released the draft IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (ETBE) for public comment and discussion. The draft assessment was reviewed internally by EPA and by other federal agencies and White House Offices before public release. Consistent with the May 2009 IRIS assessment development process, all written comments on IRIS assessments submitted by other federal agencies and White House Offices are made publicly available. Accordingly, interagency comments and the interagency science consultation materials provided to other agencies, including interagency review drafts of the IRIS Toxicological Review of Ethyl Tertiary Butyl Ether are posted on this site. EPA is undertaking an new health assessment for ethyl tertiary butyl ether (ETBE) for the Integrated Risk Information System (IRIS). The outcome of this project will be a Toxicological Review and IRIS Summary of ETBE that will be entered on the IRIS database. IRIS is an EPA database containing Agency scientific positions on potential adverse human health effects that may result from chronic (or lifetime) exposure to chemicals in the environment. IRIS contains chemical-specific summaries of qualitative and quantitative health information in support of two steps of the risk assessment process, i.e., hazard identification and dose-response evaluation. IRIS assessments are used nationally and internationally in combination with specific situational exposure assessment infor

  17. Aqueous foam toxicology evaluation and hazard review

    SciTech Connect

    Archuleta, M.M.

    1995-10-01

    Aqueous foams are aggregates of bubbles mechanically generated by passing air or other gases through a net, screen, or other porous medium that is wetted by an aqueous solution of surface-active foaming agents (surfactants). Aqueous foams are important in modem fire-fighting technology, as well as for military uses for area denial and riot or crowd control. An aqueous foam is currently being developed and evaluated by Sandia National Laboratories (SNL) as a Less-Than-Lethal Weapon for the National Institute of Justice (NIJ). The purpose of this study is to evaluate the toxicity of the aqueous foam developed for the NIJ and to determine whether there are any significant adverse health effects associated with completely immersing individuals without protective equipment in the foam. The toxicity of the aqueous foam formulation developed for NIJ is determined by evaluating the toxicity of the individual components of the foam. The foam is made from a 2--5% solution of Steol CA-330 surfactant in water generated at expansion ratios ranging from 500:1 to 1000:1. SteoI CA-330 is a 35% ammonium laureth sulfate in water and is produced by Stepan Chemical Company and containing trace amounts (<0.1%) of 1,4-dioxane. The results of this study indicate that Steol CA-330 is a non-toxic, mildly irritating, surfactant that is used extensively in the cosmetics industry for hair care and bath products. Inhalation or dermal exposure to this material in aqueous foam is not expected to produce significant irritation or systemic toxicity to exposed individuals, even after prolonged exposure. The amount of 1,4-dioxane in the surfactant, and subsequently in the foam, is negligible and therefore, the toxicity associated with dioxane exposure is not significant. In general, immersion in similar aqueous foams has not resulted in acute, immediately life-threatening effects, or chronic, long-term, non-reversible effects following exposure.

  18. Experimental toxicology of pyrolysis and combustion hazards.

    PubMed Central

    Cornish, H H; Hahn, K J; Barth, M L

    1975-01-01

    Data are presented on the acute toxicity (mortality only) of the thermal degradation products of polymers obtained by two methods of degradation. One system utilized a slowly increasing temperature (5 degrees C/min) and gradual degradation of the polymer with the rats being exposed to degradation products as they were evolved. In this system the more toxic polymers included wool, polypropylene, poly(vinyl chloride), and urethane foam. The second system utilized conditions of rapid combustion and exposure of rats to the total products of combustion for a period of 4 hr. In this system the more toxic materials included red oak, cotton, acrylonitrile-butadiene-styrene (ABS), and styrene-acrylonitrile. It is of interest to note that the natural product wool is among the least toxic under these rapid combustion conditions and among the most toxic under slow pyrolysis conditions. Other materials also vary in the comparative toxicity of their thermal degradation products, depending upon the conditions of degradation and animal exposure. The two experimental techniques presented here may well represent the two extreme conditions of rapid combustion versus slow pyrolysis. Intermediate types of fire situations might be expected to result in relative acute toxicities somewhere between these two extremes. This report deals with acute toxicity on the basis of mortality data only and does not include other parameters of toxicity such as organ weights and histopathology. PMID:1175552

  19. Diesel exhaust particulate (DEP) and nanoparticle exposures: what do DEP human clinical studies tell us about potential human health hazards of nanoparticles?

    PubMed

    Hesterberg, Thomas W; Long, Christopher M; Lapin, Charles A; Hamade, Ali K; Valberg, Peter A

    2010-07-01

    Engineered nanoparticles (ENPs) are increasingly tested in cellular and laboratory-animal experiments for hazard potential, but there is a lack of health effects data for humans exposed to ENPs. However, human data for another source of nanoparticle (NP) exposure are available, notably for the NPs contained in diesel exhaust particulate (DEP). Studies of human volunteers exposed to diesel exhaust (DE) in research settings report DEP-NP number concentrations (i.e., >10(6) particles/cm(3)) that exceed number concentrations reported for worst-case exposure conditions for workers manufacturing and handling ENPs. Recent human DE exposure studies, using sensitive physiological instrumentation and well-characterized exposure concentrations and durations, suggest that elevated DE exposures from pre-2007 engines may trigger short-term changes in, for example, lung and systemic inflammation, thrombogenesis, vascular function, and brain activity. Considerable uncertainty remains both as to which DE constituents underlie the observed responses (i.e., DEP NPs, DEP mass, DE gases), and as to the implications of the observed short-term changes for the development of disease. Even so, these DE human clinical data do not give evidence of a unique toxicity for NPs as compared to other small particles. Of course, physicochemical properties of toxicological relevance may differ between DEP NPs and other NPs, yet overall, the DE human clinical data do not support the idea that elevated levels of NPs per se (at least in the DEP context) must be acutely toxic by virtue of their nano-sized nature alone.

  20. The preservation potential of onshore tsunami sediments - implications for hazard assessment (Invited)

    NASA Astrophysics Data System (ADS)

    Spiske, M.; Piepenbreier, J.; Benavente, C. L.; Bahlburg, H.

    2013-12-01

    Over the last decades, numerous post-tsunami surveys documented the characteristics of sedimentary and erosional features caused by onshore tsunami inundation. Even though unique sedimentological characteristics have not been recognized, the available data help to identify ancient tsunami deposits and to extend the tsunami record of a given coastal area back in time. Consequently recurrence intervals of tsunami and related hazards can be better constrained. However, the style of preservation and the extent of post-depositional and diagenetic changes of such deposits have not yet been thoroughly assessed. Here we present results of a survey of Holocene siliciclastic onshore tsunami sediments found in Peru and Chile. We explore how coastal topography, depositional environment, climate, syn- and post-seismic tectonic movements, and the mineralogical composition influence the style and extent of preservation of tsunami deposits. We report that sediments deposited in areas affected by seasonal rainfalls, such as hurricane seasons, wet winter months, or infrequent climate phenomena like El Niño events, will be altered and potentially removed shortly after an event. The rapid burial with post-tsunami sediments helps to protect the event deposits from surface modifications. Tsunami deposits, especially of the last or the greatest wave can possess an increased preservation potential, because they will not be affected by successive waves. This holds especially for sediments deposited on flat coastal plains where the backwash is either weak or channelized. A larger distance to the shoreline places deposits out of reach of normal wave and tide action. Eolian processes can erode sediments quickly, or smoothen and infill scoured surfaces. Coarser deposits may have a higher preservation potential compared to muddy deposits because they are less likely to be reworked by run-off or wind. By contrast, muddy tsunami deposits may escape erosion by wind in some areas because of the

  1. EU alerting and reporting systems for potential chemical public health threats and hazards.

    PubMed

    Orford, R; Crabbe, H; Hague, C; Schaper, A; Duarte-Davidson, R

    2014-11-01

    A number of European and international IT platforms are used to notify competent authorities of new potential chemical exposures. Recently the European Parliament and the Council of European Union adopted new legislation that aims to improve the co-ordinated response to cross border health threats (Decision 1082/2013/EU). The Decision, inter alia, sets provisions on notification, ad hoc monitoring and coordination of public health measures following serious cross border threats to health from biological, chemical and environmental events as well as events that have an unknown origin. The legal instrument applies to all European Union Member States and is comparable to the International Health Regulations in its content, requirements and adoption of a multiple hazards approach. An inter-sectoral and multidisciplinary response to events with potentially dangerous cross border exposure pathways is often required. For example, European Poisons Centres may be aware of cases of toxic exposure to a product and, in parallel, trading standards may be aware of the same product due to a breach of consumer product standards. Whilst both cases would have been recorded for separate purposes in different alerting systems, they relate to the same exposure pathway; therefore a process for linking these records would allow a more robust approach to risk assessment and risk mitigation. The Decision seeks to reconcile this issue for serious threats by linking relevant platforms into one overarching higher level risk management IT platform called the Early Warning Response System (EWRS). This system will serve to link other sectors within the European Commission (EC) to public health (e.g. medicines), as well as other EU agencies and international bodies via co-notification features. Other European alert systems will be linked to EWRS to facilitate information sharing at both the assessment and management levels. This paper provides a timely overview of the main systems run by the EC

  2. Aggregated Computational Toxicology Online Resource

    EPA Pesticide Factsheets

    Aggregated Computational Toxicology Online Resource (AcTOR) is EPA's online aggregator of all the public sources of chemical toxicity data. ACToR aggregates data from over 1,000 public sources on over 500,000 chemicals and is searchable by chemical name, other identifiers and by chemical structure. It can be used to query a specific chemical and find all publicly available hazard, exposure and risk assessment data. It also provides access to EPA's ToxCast, ToxRefDB, DSSTox, Dashboard and DSSTox data.

  3. Potential hazards from floodflows and debris movement in the Furnace Creek area, Death Valley National Monument, California-Nevada

    USGS Publications Warehouse

    Crippen, John R.

    1979-01-01

    Death Valley is known as the driest and hottest region in the United States. Despite the aridity of the valley itself, however , very heavy rainfall sometimes occurs in the nearby mountains. Such violent rainstorms are likely to be of relatively short duration and to occur over rather small areas; nevertheless, they sometimes produce large floodflows that in turn cause severe erosion and flows of debris. The debris-laden flows may be hazardous to life and property. Given sufficient knowledge of the hydrologic and hydraulic environment, the degree of hazard can be estimated. Potential hazards are defined for areas in the vicinity of the Furnace Creek fan and the Park Service residential area. (Woodard-USGS)

  4. Assessment of existing and potential landslide hazards resulting from the April 25, 2015 Gorkha, Nepal earthquake sequence

    USGS Publications Warehouse

    Collins, Brian D.; Jibson, Randall W.

    2015-07-28

    This report provides a detailed account of assessments performed in May and June 2015 and focuses on valley-blocking landslides because they have the potential to pose considerable hazard to many villages in Nepal. First, we provide a seismological background of Nepal and then detail the methods used for both external and in-country data collection and interpretation. Our results consist of an overview of landsliding extent, a characterization of all valley-blocking landslides identified during our work, and a description of video resources that provide high resolution coverage of approximately 1,000 kilometers (km) of river valleys and surrounding terrain affected by the Gorkha earthquake sequence. This is followed by a description of site-specific landslide-hazard assessments conducted while in Nepal and includes detailed descriptions of five noteworthy case studies. Finally, we assess the expectation for additional landslide hazards during the 2015 summer monsoon season.

  5. Laboratory Safety and Chemical Hazards.

    ERIC Educational Resources Information Center

    Journal of Chemical Education, 1983

    1983-01-01

    Toxicology/chemical hazards, safety policy, legal responsibilities, adequacy of ventilation, chemical storage, evaluating experimental hazards, waste disposal, and laws governing chemical safety were among topics discussed in 10 papers presented at the Seventh Biennial Conference on Chemical Education (Stillwater, Oklahoma 1982). Several topics…

  6. Distribution of potentially hazardous trace elements in coals from Shanxi province, China

    USGS Publications Warehouse

    Zhang, J.Y.; Zheng, C.G.; Ren, D.Y.; Chou, C.-L.; Liu, J.; Zeng, R.-S.; Wang, Z.P.; Zhao, F.H.; Ge, Y.T.

    2004-01-01

    Shanxi province, located in the center of China, is the biggest coal base of China. There are five coal-forming periods in Shanxi province: Late Carboniferous (Taiyuan Formation), Early Permian (Shanxi Formation), Middle Jurassic (Datong Formation), Tertiary (Taxigou Formation), and Quaternary. Hundred and ten coal samples and a peat sample from Shanxi province were collected and the contents of 20 potentially hazardous trace elements (PHTEs) (As, B, Ba, Cd, Cl, Co, Cr, Cu, F, Hg, Mn, Mo, Ni, Pb, Sb, Se, Th, U, V and Zn) in these samples were determined by instrumental neutron activation analysis, atomic absorption spectrometry, cold-vapor atomic absorption spectrometry, ion chromatography spectrometry, and wet chemical analysis. The result shows that the brown coals are enriched in As, Ba, Cd, Cr, Cu, F and Zn compared with the bituminous coals and anthracite, whereas the bituminous coals are enriched in B, Cl, Hg, and the anthracite is enriched in Cl, Hg, U and V. A comparison with world averages and crustal abundances (Clarke values) shows that the Quaternary peat is highly enriched in As and Mo, Tertiary brown coals are highly enriched in Cd, Middle Jurassic coals, Early Permian coals and Late Carboniferous coals are enriched in Hg. According to the coal ranks, the bituminous coals are highly enriched in Hg, whereas Cd, F and Th show low enrichments, and the anthracite is also highly enriched in Hg and low enrichment in Th. The concentrations of Cd, F, Hg and Th in Shanxi coals are more than world arithmetic means of concentrations for the corresponding elements. Comparing with the United States coals, Shanxi coals show higher concentrations of Cd, Hg, Pb, Se and Th. Most of Shanxi coals contain lower concentrations of PHTEs. ?? 2004 Elsevier Ltd. All rights reserved.

  7. The potential of the Phytotoxkit microbiotest for hazard evaluation of sediments in eutrophic freshwater ecosystems.

    PubMed

    Czerniawska-Kusza, Izabela; Kusza, G

    2011-08-01

    The applicability of the Phytotoxkit microbiotest for toxicity assessment of sediments in eutrophic freshwater ecosystems was evaluated. Sediments were collected from Turawa dam reservoir (southwestern Poland) which, for years, has been subjected to a marked nutrient enrichment and heavy metal contamination. The test plant species were exposed to whole sediments, solid phases of sediments, and pore waters. Phytotoxicity was estimated on the basis of seed germination and root elongation measurements, combined into an overall germination index (GI). For pore waters, the majority of GI values were not statistically different from the controls, which was consistent with chemical data. For solid phases and whole sediments, GI values showed diversified effects ranging from growth stimulation to growth inhibition. The results obtained vary depending on the plant species and the type of sediment samples. Generally, tests with solid phases of sediments showed phytostimulation, suggesting that higher amount of nutrients adsorbed on organic matter-rich sediments might conceal the inhibitory impact of heavy metals (Cd, Cr, Cu, Mn, Ni, Pb, and Zn). However, this beneficial impact is indicative of a significant nutrient load and, with respect to aquatic ecosystems, its potential resuspention that might accelerate the reservoir eutrophication. Under appropriate conditions heavy metals exerted stronger negative impact on plants. Tests with whole sediments had a higher acidity (pH 5.85) and showed adverse effects, though plant responses vary from inhibition (Lepidium sativum) to stimulation (Sorghum saccharatum). The study demonstrated variability in toxicity of contaminated nutrient-rich sediments as well as effectiveness and usefulness of the Phytotoxkit microbiotest as a practical and reliable tool for evaluation of the hazard of eutrophic ecosystems to higher plants.

  8. Meteorite Associations and Source Regions for Potentially Hazardous Near-Earth Objects

    NASA Astrophysics Data System (ADS)

    Binzel, Richard P.; Vernazza, P.; Thomas, C. A.; DeMeo, F. E.; Bus, S. J.; Rivkin, A. S.; Tokunaga, A. T.

    2008-09-01

    We report results from Vernazza et al. (2008; Nature, August 14 issue) showing that 2/3 of all large near-Earth objects (NEOs), including the potentially hazardous asteroid (PHA) subset, have spectral characteristics consistent with laboratory measurements of LL-chondrite meteorites. Our NEO data (38 S- and Q-types) were obtained through a joint observational program (MIT, Hawaii, IRTF). Comparison meteorite data were obtained from the Brown University RELAB database. Our asteroid-meteorite comparative analysis was performed using quantitative measurements of spectral band centers and band area ratios and using a radiative transfer model for olivine (olv) and orthopyroxene (opx) (Shkuratov 1999; Icarus 137, 235). Most large NEOs (and the PHA subset) show relatively high olv/(olv+opx) ratios in the 70-85% range typical for LL-chondrites. Interestingly, relatively high olivine abundances are found among S-type asteroids in the inner main-belt Flora region (Gaffey 1984; Icarus 60, 38: Chapman 1996; MPS 31, 699) adjacent to the nu6 secular resonance. An LL chondrite association for most large (km-sized) NEOs and PHAs is surprising since LL chondrites are somewhat rare ( 8% of all meteorite falls). One possible explanation is Yarkovsky drift. Large objects (such as km-sized NEOs in our sample) experience relatively little Yarkovsky drift. In contrast, meter-sized objects (which dominate meteorite fall statistics) experience substantial Yarkovsky drift. Limited Yarkovsky drift therefore restricts the delivery of the largest NEOs to the most favorable source region(s), such as the nu6 resonance bordering the Flora region. Substantial Yarkovsky drift of meter-sized objects throughout the main belt allows meteorite fall statistics to sample from numerous main-belt resonances. Thus, meteorite falls sample throughout_the_asteroid_belt (not just the inner belt). Such a size-dependent efficiency therefore enhances the inner main belt as the source for large NEOs and PHAs

  9. Fluvoxamine drastically increases concentrations and effects of tizanidine: a potentially hazardous interaction.

    PubMed

    Granfors, Marika T; Backman, Janne T; Neuvonen, Mikko; Ahonen, Jouni; Neuvonen, Pertti J

    2004-04-01

    Our objective was to study the effect of fluvoxamine on the pharmacokinetics and pharmacodynamics of tizanidine, a centrally acting skeletal muscle relaxant. In a double-blind, randomized, 2-phase crossover study, 10 healthy volunteers took 100 mg fluvoxamine or placebo orally once daily for 4 days. On day 4, each ingested a single 4-mg dose of tizanidine. Plasma concentrations of tizanidine and fluvoxamine and pharmacodynamic variables were measured. A caffeine test was performed on day 3 to examine the role of cytochrome P450 (CYP) 1A2 in tizanidine pharmacokinetics. On average, fluvoxamine increased the total area under the concentration-time curve [AUC(0- infinity )] of tizanidine 33-fold (range, 14-fold to 103-fold; P =.000002) and the peak plasma concentration 12-fold (range, 5-fold to 32-fold; P =.000001). The mean elimination half-life of tizanidine was prolonged from 1.5 to 4.3 hours (P =.00004) by fluvoxamine. The AUC(0- infinity ) of tizanidine and its increase by fluvoxamine correlated with the caffeine/paraxanthine ratio and its increase, respectively (P <.03). All pharmacodynamic variables revealed a significant difference between the fluvoxamine and placebo phases, eg, in the maximal effects on systolic blood pressure (-35 mm Hg, P =.000009), diastolic blood pressure (-20 mm Hg, P =.00002), heart rate (-4 beats/min, P =.007), Digit Symbol Substitution Test (P =.0003), subjective drug effect (P =.0000001), and drowsiness (P =.0002). In particular, the decrease in systolic blood pressure, to the level of 80 mm Hg or even less, was an alarming finding. Fluvoxamine seriously affects the pharmacokinetics of tizanidine and increases the intensity and duration of its effects. Inhibition of tizanidine-metabolizing enzyme(s), mainly CYP1A2, by fluvoxamine seems to explain the observed interaction. Because of the potentially hazardous consequences, the concomitant use of tizanidine with fluvoxamine, or other potent inhibitors of CYP1A2, should be avoided.

  10. Extended-spectrum beta-lactamase-producing Pseudomonas aeruginosa in camel in Egypt: potential human hazard.

    PubMed

    Elhariri, Mahmoud; Hamza, Dalia; Elhelw, Rehab; Dorgham, Sohad M

    2017-03-31

    The rapid increase of extended-spectrum beta-lactamase (ESBL) producing bacteria are a potential health hazard. Development of antimicrobial resistance in animal pathogens has serious implications for human health, especially when such strains could be transmitted to human. In this study, the antimicrobial resistance due to ESBL producing Pseudomonas aeruginosa in the camel meat was investigated. In this study meat samples from 200 healthy camels at two major abattoirs in Egypt (Cairo and Giza) were collected. Following culture on cetrimide agar, suspected P. aeruginosa colonies were confirmed with a Vitek 2 system (bioMe´rieux). P. aeruginosa isolates were phenotypically identified as ESBL by double disk synergy test. Additionally antimicrobial susceptibility testing of ESBL producing P. aeruginosa isolates were done against 11 antimicrobial drugs and carried out by disk diffusion method. The ESBL genotypes were determined by polymerase chain reaction according to the presence of the bla PER-1, bla CTX-M, bla SHV, and bla TEM. Pseudomonas aeruginosa was isolated from 45 camel meat sample (22.5%). The total percentage of ESBL producing P. aeruginosa was 45% (21/45) from camel meat isolates. Antibiogram results revealed the highest resistance was for c, ceftriaxone and rifampicin followed by cefepime and aztreonam. The prevalence rates of β-lactamase genes were recorded (bla PER-1 28.5%, bla CTX-M 38%, bla SHV 33.3% and bla TEM 23.8%). This study illustrates the presence of high rates of ESBL-P. aeruginosa in camels that represents an increasing alarming for the risk of transmission to human and opens the door for current and future antibiotics therapy failure. Livestock associated ESBL-P. aeruginosa is a growing disaster, therefore, attention has to be fully given to livestock associated ESBL-bacteria which try to find its way to human beings.

  11. Potential hazards of fenvalerate in massive pollution influence the apoptosis sensitivity.

    PubMed

    Cui, Zheng-Guo; Jin, Yu-Jie; Sun, Lu; Zakki, Shahbaz Ahmad; Li, Meng-Ling; Feng, Qian-Wen; Kondo, Takashi; Ogawa, Ryohei; Inadera, Hidekuni

    2017-09-26

    Fenvalerate (Fen), a synthetic pyrethroid insecticide, is widely used in agricultural, domestic and veterinary applications. Fen induces abnormal cell proliferation and apoptosis, which are linked to its hazardous effects. However, this view is controversial and the underlying molecular mechanisms remain elusive. In the present study, the effects of Fen on cadmium (Cd)-induced apoptosis and the associated molecular mechanisms were investigated in human myeloid leukemia U937 cells. U937 cells were treated with 50 μm cadmium chloride (CdCl2 ) with or without Fen pretreatment at 1-50 μm. Apoptosis was evaluated by externalization of phosphatidylserine on the plasma membrane. The expression levels of apoptosis-related proteins, including Bcl-2 family members were determined by western blot analysis. The results revealed that pretreatment with Fen at 20 μm for 12 hours significantly inhibited Cd-induced apoptosis. Decreased expression of pro-apoptotic Bcl-2 family proteins (Noxa and Bid) and increased expression of anti-apoptotic proteins (Bcl-xL, Mcl-1 and XIAP) were observed after combined treatment with Fen and CdCl2 . Phosphorylation of ERK and AKT was increased, while phosphorylation of JNK was decreased by the combined treatment, compared with CdCl2 treatment alone. In conclusion, Fen decreased apoptotic sensitivity induced by Cd in U937 cells. This effect was associated with activation of ERK and AKT, suppression of JNK and changes in expression of Bcl-2 family proteins and XIAP. The present findings suggest a potential influence of Fen on Cd toxicity via suppression of apoptosis. Fen decreased apoptotic sensitivity induced by Cd, and thus it may contribute carcinogenic risk and influence on cancer therapy. Copyright © 2017 John Wiley & Sons, Ltd.

  12. Advanced Materials Laboratory hazards assessment document

    SciTech Connect

    Barnett, B.; Banda, Z.

    1995-10-01

    The Department of Energy Order 55OO.3A requires facility-specific hazards assessments be prepared, maintained, and used for emergency planning purposes. This hazards assessment document describes the chemical and radiological hazards associated with the AML. The entire inventory was screened according to the potential airborne impact to onsite and offsite individuals. The air dispersion model, ALOHA, estimated pollutant concentrations downwind from the source of a release, taking into consideration the toxicological and physical characteristics of the release site, the atmospheric conditions, and the circumstances of the release. The greatest distance at which a postulated facility event will produce consequences exceeding the Early Severe Health Effects threshold is 23 meters. The highest emergency classification is a General Emergency. The Emergency Planning Zone is a nominal area that conforms to DOE boundaries and physical/jurisdictional boundaries such as fence lines and streets.

  13. Genetic toxicology and preliminary in vivo studies of nitric oxide donor tocopherol analogs as potential new class of antiatherogenic agents.

    PubMed

    Cabrera, Mauricio; López, Gloria V; Gómez, Luis E; Breijo, Martín; Pintos, Cristina; Botti, Horacio; Raymondo, Stella; Vettorazzi, Ariane; Ceráin, Adela López de; Monge, Antonio; Rubbo, Homero; González, Mercedes; Cerecetto, Hugo

    2011-07-01

    Nitric oxide donor tocopherol analogs were found to be incorporated in low-density lipoprotein to release nitric oxide into the hydrophobic core of the lipoprotein, thus inhibiting lipid oxidation processes associated with atheroma plaque formation. Previously, we studied their cytotoxicity against human and murine macrophages as first selection for in vivo studies. Herein, we examined both the in vitro mutagenic and DNA-damage effects of selected compounds to further evaluate drug potential. While the compounds of interest were nongenotoxics in both experimental tests (Ames and alkaline comet), one of the potential blood metabolites exhibited genotoxicity (alkaline comet test), and the furazan derivative was mutagenic (Ames test). Two selected (nitrooxy and furoxan) compounds were studied in long- and short-term in vivo treatment, and in these conditions, animal toxicity was not evidenced, suggesting the possibility of these compounds as potential antiatherogenic drugs.

  14. Potential geologic hazards and constraints for blocks in proposed Mid-Atlantic OCS oil and gas lease sale 49

    USGS Publications Warehouse

    Hall, R. W.; Ensminger, H. Robert

    1979-01-01

    Analysis of side-scan sonar, subbottom profiler, processed sparker, and fathometer data (approximately 5060 km) from the 136 blocks in the proposed Outer Continental Shelf Lease Sale 49 disclosed features that are potential geologic hazards to oil and gas exploration and development operations. These potential hazards are past mass sediment movement (slumping or sliding) in parts or all of 57 proposed lease sale blocks (27 of which are virtually covered by slumped materials), shallow gas deposits in three proposed lease sale blocks, and recent shallow faulting in one proposed lease sale block. Other features considered merely to be developmental constraints can be accommodated by existing standard design and engineering technology: erosion and scour, sand waves, filled channels, acoustically turbid zones (gassy sediments), lagoonal sediments, potentially unstable slopes (due to gradient), unidentified bottom objects, and a shipwreck.

  15. Changes in evaporation and potential hazards associated with ice accretion in a "New Arctic"

    NASA Astrophysics Data System (ADS)

    Boisvert, L.

    2016-12-01

    The Arctic sea ice acts as a barrier between the ocean and atmosphere inhibiting the exchange of heat, momentum, and moisture. Recently, the Arctic has seen unprecedented declines in the summer sea ice area, changing to a "New Arctic" climate system, one that is dominated by processes affected by large ice-free areas for the majority of the year as the melt season lengthens. Using atmospheric data from the Atmospheric Infrared Sounder (AIRS) instrument, we found that accompanying this loss of sea ice, the Arctic is becoming warmer and wetter. Evaporation, which plays an important role in the Arctic energy budget, water vapor feedback, and Arctic amplification, is also changing. The largest increases seen in evaporation are in the Arctic coastal seas during the spring and fall where there has been a reduction in sea ice cover and an increase in sea surface temperatures. Increases in evaporation also correspond to increases in low-level clouds. In this "New Arctic" transportation and shipping throughout the Arctic Ocean is becoming a more viable option as the areas in which ships can travel and the time period for ship travel continue to increase. There are various hazards associated with Arctic shipping, one being ice accretion. Ice accretion is the build up of ice on the surface of ships as they travel through regions of specific meteorological conditions unique to high-latitude environments. Besides reduced visibility, this build up of ice can cause ships to sink or capsize (by altering the ships center of gravity) depending on the severity and/or the location of ice build-up. With these changing atmospheric conditions in the Arctic, we expect there have been increases in the ice accretion potential over recent years, and an increase in the likelihood of high, and potentially dangerous ice accretion rates. Improved understanding of how this rapid loss of sea ice affects the "New Arctic" climate system, how evaporation is changing and how ice accretion could change

  16. The potentially hazardous asteroid 1996 JG and the North omega-Scorpiid meteoroid stream

    NASA Astrophysics Data System (ADS)

    Madiedo, J.; Trigo-Rodríguez, J.

    2014-07-01

    During the end of May and mid June, meteor and fireball activity from the Scorpiid-Sagitariid complex can be noticed. One of the streams belonging to this complex is the North ω-Scorpiids (NSC), which was previously designated by some authors as the ω-Scorpiids [1]. This is included in the IAU Working list of meteor showers with the code 66 NSC (REF). The activity period of this minor shower goes from May 23 to June 15 with a maximum around June 1st. The Apollo-type orbit of NSC meteoroids let Drummond to propose 1862 Apollo as the parent asteroid of this meteor shower [2]. Nowadays, however, the potentially-hazardous asteroid (PHA) 1996 JG is included among the potential parent bodies of this stream [1]. We report here a magnitude -10 fireball recorded on June 6, 2010, at 23h18m38 ± 1s UTC from two video stations working in the framework of the SPanish Meteor Network (SPMN). High-sensitivity CCD video cameras recorded the event and allowed the reconstruction of the atmospheric trajectory, velocity, and radiant determination. From such data the orbital elements of the meteoroid were obtained, finding a clear association with the North ω-Scorpiids meteoroid stream. The emission spectrum produced by this event, which received the code SPMN060610, is also analyzed. From the deduced orbital elements, by using the ORAS software (ORbital Association Software) we confirm that asteroid 1996 JG is the likely parent body of the North ω-Scorpiid stream. Thus, for example, by using the Southworth and Hawkins dissimilarity criterion, we obtain a value of D_{SH} of about 0.09 [3]. In addition, we have performed an orbital integration by using the Mercury 6 software [4]. The gravitational fields of Venus, the Earth-Moon system, Mars, Jupiter and Saturn were considered. The orbits of 1996 JG and the SPMN060610 meteoroid were integrated back for 20,000 years. As shown in the figure, the DSH criterion reveals a link between both bodies, with the values of DSH being less than 0

  17. MINING ENVIRONMENTAL TOXICOLOGY INFORMATION WEB RESOURCES

    EPA Science Inventory

    Environmental toxicology is the study of the ecological effects of anthropogenic substances released into the environment. It is a relatively diverse field addressing impacts to aquatic and terrestrial organisms and communities. The determination of potential risk associated with...

  18. ATSDR evaluation of potential for human exposure to zinc.

    PubMed

    Roney, Nickolette; Osier, Mark; Paikoff, Sari J; Smith, Cassandra V; Williams, Malcolm; De Rosa, Christopher T

    2007-01-01

    As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) National Priorities List (NPL) sites that have the greatest public health impact. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of portions of the toxicological profile for zinc. The primary purpose of this article is to provide interested individuals with environmental information on zinc that includes production data, environmental fate, potential for human exposure, analytical methods and a listing of regulations and advisories.

  19. ATSDR evaluation of potential for human exposure to benzene.

    PubMed

    Wilbur, S; Wohlers, D; Paikoff, S; Keith, L S; Faroon, O

    2008-01-01

    As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) sites that have the greatest public health impact. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of portions of the toxicological profile for benzene. The primary purpose of this article is to provide interested individuals with environmental information on benzene that includes production data, environmental fate, potential for human exposure, analytical methods, and a listing of regulations and advisories.

  20. Potential flood hazards and hydraulic characteristics of distributary-flow areas in Maricopa County, Arizona

    USGS Publications Warehouse

    Hjalmarson, H.W.

    1994-01-01

    Flood hazards of distributary-flow areas in Maricopa County, Arizona, can be distinguished on the basis of morphological features. Five distributary-flow areas represent the range of flood-hazard degree in the study area. Descriptive factors, including the presence of desert varnish and the absence of saguaro cactus, are more useful than traditional hydraulic-based methods in defining hazards. The width, depth, and velocity exponents of the hydraulic-geometry relations at the primary diffluences of the sites are similar to theoretical exponents for streams with cohesive bank material and the average exponents of stream channels in other areas in the United States. Because of the unexplained scatter of the values of the exponent of channel width, however, the use of average hydraulic-geometry relations is con- sidered inappropriate for characterizing flood hazards for specific distributary-flow in Maricopa County. No evidence has been found that supports the use of stochastic modeling of flows or flood hazards of many distributary-flow areas. The surface of many distributary-flow areas is stable with many distributary channels eroded in the calcreted surface material. Many distributary- flow areas do not appear to be actively aggrading today, and the paths of flow are not changing.

  1. Toxicological assessment of multi-walled carbon nanotubes in vitro: potential mitochondria effects on male reproductive cells

    PubMed Central

    Xu, Cheng; Liu, Qian; Liu, Hui; Zhang, Chunlan; Shao, Wentao; Gu, Aihua

    2016-01-01

    Multi-walled carbon nanotubes (MWCNTs) have been widely used in many fields and were reported to cause reversible testis damage in mice at high-dose. However the reproductive effects of low dose MWCNTs remained elusive. Herein, we used the mice spermatocyte cell line (GC-2spd) to assess the reproductive effects of MWCNTs. Size distribution, zeta potential, and intensity of MWCNTs were characterized. A maximal concentration of 0.5 μg/mL MWCNTs was found to be nonlethal to GC-2spd. At this dose, cell cycles and the ROS levels were in normal status. We also found MWCNTs accumulated in mitochondria, which caused potential mitochondrial DNA damage in spermatocyte. Furthermore, the expression level of mitochondria-related genes, the oxygen consumption rate, and cellular ATP content were declined compared to controls, even at the nonlethal dose. Our results suggested for the first time that, in germ cells, mitochondrion was a cellular organelle that accumulated MWCNTs. PMID:27248475

  2. An accurate evaluation of the potential hazardous impact of Polycyclic Aromatic Hydrocarbons in biochars

    NASA Astrophysics Data System (ADS)

    María De la Rosa, José; Sánchez-Martín, Águeda; Villaverde-Capellán, Jaime; Madrid, Fernando; Paneque, Marina; Knicker, Heike

    2017-04-01

    Biochar may act as a soil conditioner, enhancing plant growth by supplying and retaining nutrients and by providing other services such as improving soil physical, chemical and biological properties. Feedstock properties and production conditions drive the nature of produced biochars [1]. Special attention have to be paid to their content of polycyclic aromatic hydrocarbons (PAHs), which are persistent organic pollutants formed during biochar production due to incomplete combustion (pyrolysis step) [2]. These PAHs may enter the environment when the biochar is applied as soil conditioner. Therefore, the intention of this study was to test a potential hazardous impact of biochar amendment due to the presence of PAHs. In order to find a relationship between pyrolysis conditions, feedstock and abundance of PAHs, four biochars produced from different feedstock were analyzed. Three biochars were produced by technical pyrolysis (500-600 °C; 20 min) from wood, paper sludge and sewage sludge respectively (samples B1, B2 and B3). The fourth biochar sample derived from old grapevine wood by using the traditional carbonization method in kilns (kiln-stack wood biochar; B4). A detailed characterization of physical and chemical properties of these samples can be found in De la Rosa et al, [3]. Two different PAHs extraction techniques were applied to evaluate the total and available PAHs content of the biochars. They consisted in an extraction with toluene using a Soxhlet extractor and a non-exhaustive extraction with Cyclodextrins (CDs). Chromatographic and mass spectrometric conditions applied are described in [1]. Total PAHs yielded between 3 ppm (B3) and 7 (B4) ppm. The production of biochar by using traditional kilns instead of controlled pyrolysis, increased significantly the total PAHs levels. No direct relationship was found between the total PAHs and the PAHs extracted by CDs, which can be considered as the bioavailable fraction. This parameter should replace the total

  3. Permafrost in the Himalayas: specific characteristics, evolution vs. climate change and impacts on potential natural hazards

    NASA Astrophysics Data System (ADS)

    Fort, Monique

    2015-04-01

    Mountain environments are very sensitive to climate change, yet assessing the potential impacts of these changes is not easy because of the complexity and diversity of mountain systems. The Himalayan permafrost belt presents three main specificities: (1) it develops in a geodynamically active mountain, which means that the controlling factors are not only temperature but also seismo-tectonic activity; (2) due to the steepness of the southern flank of the Greater Himalaya and potential large scale rock failures, permafrost evidence manifests itself best in the inner valleys and on the northern, arid side of the Himalayas (elevations >4000m); (3) the east-west strike of the mountain range creates large spatial discontinuity in the "cold" belt, mostly related to precipitation nature and availability. Only limited studies have been carried to date, and there is no permanent "field laboratory", nor continuous records but a few local studies. Based on preliminary observations in the Nepal Himalayas (mostly in Mustang and Dolpo districts), and Indian Ladakh, we present the main features indicating the existence of permafrost (either continuous or discontinuous). Rock-glaciers are quite well represented, though their presence may be interpreted as a combined result from both ground ice and large rock collapse. The precise altitudinal zonation of permafrost belt (specifying potential permafrost, probable permafrost, observed permafrost belts) still requires careful investigations in selected areas. Several questions arise when considering the evolution of permafrost in a context of climate change, with its impacts on the development of potential natural hazards that may affect the mountain population. Firstly, permafrost degradation (ground ice melting) is a cause of mountain slope destabilization. When the steep catchments are developed in frost/water sensitive bedrock (shales and marls) and extend to high elevations (as observed in Mustang or Dolpo), it would supply more

  4. Toxicological Benchmarks for Screening Potential Contaminants of Concern for Effects on Soil and Litter Invertebrates and Heterotrophic Process

    SciTech Connect

    Will, M.E.

    1994-01-01

    This report presents a standard method for deriving benchmarks for the purpose of ''contaminant screening,'' performed by comparing measured ambient concentrations of chemicals. The work was performed under Work Breakdown Structure 1.4.12.2.3.04.07.02 (Activity Data Sheet 8304). In addition, this report presents sets of data concerning the effects of chemicals in soil on invertebrates and soil microbial processes, benchmarks for chemicals potentially associated with United States Department of Energy sites, and literature describing the experiments from which data were drawn for benchmark derivation.

  5. The toxicology of chemosterilants

    PubMed Central

    Hayes, Wayland J.

    1964-01-01

    Sterilization of males can in certain circumstances be more efficient than killing as a method for control of insects and perhaps other pests. A number of chemicals (chemosterilants) show promise of producing sexual sterility in insects without some of the practical limitations of radiation. The most important compounds are alkylating agents. These have little immediate pharmacological action, but are notable for their selective action against haematopoietic and some other proliferating tissues. A number of alkylating agents have been shown to be mutagens in insects, bacteria, fungi, and higher plants; carcinogens in mammals; and teratogens in insects, birds, and mammals. Some produce sexual sterility, possibly in mammals as well as in insects, at doses too low to produce the other effects. Some have an established reputation as drugs for palliative treatment of leukaemia and other neoplasms. The development of insect sterilization as a vector control technique has been handicapped in part by lack of scientific information on the acute and long-term hazards that might be associated with the use of chemosterilants. In this paper the author brings together the available knowledge on the toxicology of the alkylating agents. PMID:14278008

  6. Evaluation of several biological monitoring techniques for hazard assessment of potentially contaminated wastewater and groundwater. Volume 2. Aberdeen Proving Ground Wastewater Treatment Plant. Final report, November 1988-December 1991

    SciTech Connect

    Burton, D.T.; Herriott, R.S.

    1992-07-01

    An evaluation of several biological monitoring techniques for hazard assessment of potentially contaminated effluent was conducted at the Aberdeen Proving Ground Wastewater Treatment Plant (APG-WWTP), Aberdeen Proving Ground, MD, from early May 1990 to February 13, 1991. An array of biomonitoring tests structured in a tiered hazard assessment framework was used in the evaluation of the effluent. Several levels of biological organization were included in the array of tests. Acute toxicity was evaluated on daily 24-h composite samples using a 5- and 15-min Microtox assay which employs microbial (Photobacterium phosphoreum) bioluminescent activity. Three 24-h LC50 rotifer (Brachionus rubens) toxicity tests were conducted using 24-h composite samples. The following chronic tests were all performed three times using 24-h composite samples: 96-h EC50 algal (Selenastrum capricornutum) growth test, 7-d daphnid (Ceriodaphnia dubia) survival and reproduction test, and 7-d fathead minnow (Pimephales promelas) survival and growth test. The acute rotifer tests and all chronic tests were conducted during the same periods in order to compare toxicological responses between biomonitoring systems.... Wastewater, Aquatic, Acute toxicity, Chronic toxicity, Mutagenicity, Ames, Teratogencity, FETAX, Carcinogenicity, Ventilatory biomonitoring system, Microtox, Photobacterium.

  7. Evaluation of several biological monitoring techniques for hazard assessment of potentially contaminated wastewater and groundwater. Volume 1. Aberdeen proving ground-edgewood area wastewater treatment plant. Final report, November 1988-December 1991

    SciTech Connect

    Burton, D.T.; Graves, W.C.

    1992-07-01

    An evaluation of several biological monitoring techniques for hazard assessment of potentially contaminated effluent was conducted at the Aberdeen Proving Ground-Edgewood Area Wastewater Treatment Plant (APG-EA WWTP), Aberdeen Proving Ground, MD, from January 1989 to December 13, 1989. An array of biomonitoring tests structured in a tiered hazard assessment framework was used in the evaluation of the effluent. Several levels of biological organization were included in the array of tests. Acute toxicity was evaluated on 24-h composite samples using a 15-min Microtox R assay which employs microbial (Photobacterium phosphoreum) bioluminescent activity. Two 24-h LC50 rotifer (Brachionus rubens) toxicity tests were conducted using 24-h composite samples The following chronic tests were all performed two times using 24-h composite samples: 96-h EC50 algal (Selenastrum capricornutum) growth test, 7-d daphnid (Ceriodaphnia dubia) survival and reproduction test, and 7-d fathead minnow (Pimephales promelas) survival and growth test. Generally, the acute rotifer tests and all chronic tests were conducted during the same periods in order to compare toxicological responses between biomonitoring systems.... Wastewater, Aquatic, Acute toxicity, Chronic toxicity, Mutagenicity, Ames, Teratogenicity, FETAX, Carcinogenicity, Ventilatory biomonitoring system, Microtox R, Photobacterium.

  8. Comments on Potential Geologic and Seismic Hazards Affecting Proposed Liquefied Natural Gas Site in Santa Monica Bay, California

    USGS Publications Warehouse

    Ross, Stephanie L.; Lee, Homa J.; Parsons, Tom E.; Beyer, Larry A.; Boore, David M.; Conrad, James E.; Edwards, Brian D.; Fisher, Michael A.; Frankel, Arthur D.; Geist, Eric L.; Hudnut, Kenneth W.; Hough, Susan E.; Kayen, Robert E.; Lorenson, T.D.; Luco, Nicolas; McCrory, Patricia A.; McGann, Mary; Nathenson, Manuel; Nolan, Michael; Petersen, Mark D.; Ponti, Daniel J.; Powell, Charles L.; Ryan, Holly F.; Tinsley, John C.; Wills, Chris J.; Wong, Florence L.; Xu, Jingping

    2008-01-01

    In a letter to the U.S. Geological Survey (USGS) dated March 25, 2008, Representative Jane Harman (California 36th district) requested advice on geologic hazards that should be considered in the review of a proposed liquefied natural gas (LNG) facility off the California coast in Santa Monica Bay. In 2004, the USGS responded to a similar request from Representative Lois Capps, regarding two proposed LNG facilities offshore Ventura County, Calif., with a report summarizing potential geologic and seismic hazards (Ross and others, 2004). The proposed LNG Deepwater Port (DWP) facility includes single point moorings (SPMs) and 35 miles of underwater pipelines. The DWP submersible buoys, manifolds, and risers would be situated on the floor of the southern Santa Monica Basin, in 3,000 feet of water, about 23 miles offshore of the Palos Verdes Peninsula. Twin 24-inch diameter pipelines would extend northeastward from the buoys across the basin floor, up the basin slope and across the continental shelf, skirting north around the Santa Monica submarine canyon. Figure 1 provides locations of the project and geologic features. Acronyms are defined in table 1. This facility is being proposed in a region of known geologic hazards that arise from both the potential for strong earthquakes and geologic processes related to sediment transport and accumulation in the offshore environment. The probability of a damaging earthquake (considered here as magnitude 6.5 or greater) in the next 30 years within about 30 miles (50 km) of the proposed pipeline ranges from 16% at the pipeline's offshore end to 48% where it nears land (Petersen, 2008). Earthquakes of this magnitude are capable of producing strong shaking, surface fault offsets, liquefaction phenomena, landslides, underwater turbidity currents and debris flow avalanches, and tsunamis. As part of the DWP license application for the Woodside Natural Gas proposal in Santa Monica Bay (known as the OceanWay Secure Energy Project), Fugro

  9. IRIS Toxicological Review of Biphenyl (External Review Draft) ...

    EPA Pesticide Factsheets

    EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of biphenyl that will appear in the Integrated Risk Information System (IRIS) database. EPA is undertaking a new health assessment for biphenyl for the Integrated Risk Information System (IRIS). The outcome of this project will be a Toxicological Review and IRIS and IRIS Summary of biohenyl that will be entered on the IRIS database. IRIS is an EPA database containing Agency scientific positions on potential adverse human health effects that may result from chronic (or lifetime) exposure to chemicals in the environment. IRIS contains chemical-specific summaries of qualitative and quantitative health information to evaluate potential public health risks associated with exposure assessment information to evaluate potential public health risks associated with environmental contaminants. The IRIS database is relied on for the development of risk assessments sites-specific environmental decisions, and rule making.

  10. Methodology to assess potential glint and glare hazards from concentrating solar power plants : analytical models and experimental validation.

    SciTech Connect

    Diver, Richard B., Jr.; Ghanbari, Cheryl M.; Ho, Clifford Kuofei

    2010-04-01

    With growing numbers of concentrating solar power systems being designed and developed, glint and glare from concentrating solar collectors and receivers is receiving increased attention as a potential hazard or distraction for motorists, pilots, and pedestrians. This paper provides analytical methods to evaluate the irradiance originating from specularly and diffusely reflecting sources as a function of distance and characteristics of the source. Sample problems are provided for both specular and diffuse sources, and validation of the models is performed via testing. In addition, a summary of safety metrics is compiled from the literature to evaluate the potential hazards of calculated irradiances from glint and glare. Previous safety metrics have focused on prevention of permanent eye damage (e.g., retinal burn). New metrics used in this paper account for temporary flash blindness, which can occur at irradiance values several orders of magnitude lower than the irradiance values required for irreversible eye damage.

  11. Aquatic toxicology: fact or fiction

    SciTech Connect

    Macek, K.J.

    1980-02-01

    The science of aquatic toxicology is a relatively new science. The development of the field of aquatic toxicology since 1930 is traced. The state of the art of aquatic toxicology compared with that of classical toxicology is evaluated. The science of aquatic toxicology is expected to undergo a significant period of rapid growth and development, leading ultimately to the formation of a mature science.

  12. Hazard Assessment of Glacial Lake Outburst Flood and Potential of ICTs for Coping: A Case of Eastern Himalaya of Nepal

    NASA Astrophysics Data System (ADS)

    Bhattarai, D. R.

    2015-12-01

    Retreat of glaciers and formation of glacial lakes in Nepal Himalaya have been reported to be related with the temperature rise in the region. Glacier Lake Outburst Floods (GLOF) are the growing climate induced hazards in the Himalaya. GLOF has increased the vulnerability of community and fragile ecosystem in the mountain valleys. This study has analyzed the potential impacts from GLOF in the highland of eastern Nepal and the potential role of Information Communication Technologies (ICT) to cope with such impacts. I analyzed the trend of climatic pattern (temperature and precipitation) of the Eastern Himalaya Region of Nepal available from the Department of Hydrology and Meteorology, Government of Nepal, and prepared the latest location map of the glacial lakes using google earth and ArcGIS applications in the highland of the Kanchanjungha Conservation Area of the region. Tiptala glacial lake, located at an elevation of 4950 m, within the conservation area, was selected for the GLOF hazard assessment. I used semi-structured questionnaire survey and key informants' interviews in the community in order to assess the potential hazard of GLOF. With the varying sizes, 46 glacial lakes were located in the region, which covers over 2.57 sq. km in total. Though the larger portion of the downstream area of the Tiptala glacial lake fall in the remote location away from major residential area, few villages, major pasture lands for Yaks, foot trails, and several bridges across the Tamor River below the lake are in risk of GLOF. Poor access due to extreme geographical remoteness and capacity to afford the modern technologies in the community are the major limiting factor to the knowledge and information about the climate change and related impacts. Modern ICTs has high potential to reduce the risk of climate related hazards in the remote area by information dissemination and awareness.

  13. Toxicology: then and now.

    PubMed

    Langman, Loralie J; Kapur, Bhushan M

    2006-05-01

    Toxicology is "the science of poisons"; more specifically the chemical and physical properties of poisons, their physiological or behavioral effects on living organisms, qualitative, and quantitative methods for their analysis and the development of procedures for the treatment of poisoning. Although the history of poisons dates to the earliest times, the study and the science of toxicology can be traced to Paracelsus (1493-1541) and Orfila (1757-1853). Modern toxicology is characterized by sophisticated scientific investigation and evaluation of toxic exposures. The 20th century is marked by an advanced level of understanding of toxicology. DNA and various biochemicals that maintain cellular functions were discovered. Our level of knowledge of toxic effects on organs and cells is now being revealed at the molecular level. This paper will review the historical progress of clinical and forensic toxicology by exploring analytical techniques in drug analysis, differing biological matrices, clinical toxicology, therapeutic drug management, workplace drug testing, and pharmacodynamic monitoring and pharmacogenetics.

  14. Potential flood hazard assessment by integration of ALOS PALSAR and ASTER GDEM: a case study for the Hoa Chau commune, Hoa Vang district, in central Vietnam

    NASA Astrophysics Data System (ADS)

    Huong, Do Thi Viet; Nagasawa, Ryota

    2014-01-01

    The potential flood hazard was assessed for the Hoa Chau commune in central Vietnam in order to identify the high flood hazard zones for the decision makers who will execute future rural planning. A new approach for deriving the potential flood hazard based on integration of inundation and flow direction maps is described. Areas inundated in the historical flood event of 2007 were extracted from Advanced Land Observing Satellite (ALOS) phased array L-band synthetic aperture data radar (PALSAR) images, while flow direction characteristics were derived from the ASTER GDEM to extract the depressed surfaces. Past flood experience and the flow direction were then integrated to analyze and rank the potential flood hazard zones. The land use/cover map extracted from LANDSAT TM and flood depth point records from field surveys were utilized to check the possibility of susceptible inundated areas, extracting data from ALOS PALSAR and ranking the potential flood hazard. The estimation of potential flood hazard areas revealed that 17.43% and 17.36% of Hoa Chau had high and medium potential flood hazards, respectively. The flow direction and ALOS PALSAR data were effectively integrated for determining the potential flood hazard when hydrological and meteorological data were inadequate and remote sensing images taken during flood times were not available or were insufficient.

  15. gammaH2AX: A potential DNA damage response biomarker for assessing toxicological risk of tobacco products.

    PubMed

    Albino, Anthony P; Jorgensen, Ellen D; Rainey, Patrick; Gillman, Gene; Clark, T Jeffrey; Gietl, Diana; Zhao, Hong; Traganos, Frank; Darzynkiewicz, Zbigniew

    2009-08-01

    Differentiation among American cigarettes relies primarily on the use of proprietary tobacco blends, menthol, tobacco substitutes, paper porosity, paper additives, and filter ventilation. These characteristics substantially alter per cigarette yields of tar and nicotine in standardized protocols promulgated by government agencies. However, due to compensatory alterations in smoking behavior to sustain a preferred nicotine dose (e.g., by increasing puff frequency, inhaling more deeply, smoking more cigarettes per day, or blocking filter ventilation holes), smokers actually inhale similar amounts of tar and nicotine regardless of any cigarette variable, supporting epidemiological evidence that all brands have comparable disease risk. Consequently, it would be advantageous to develop assays that realistically compare cigarette smoke (CS)-induced genotoxicity regardless of differences in cigarette construction or smoking behavior. One significant indicator of potentially carcinogenic DNA damage is double strand breaks (DSBs), which can be monitored by measuring Ser 139 phosphorylation on histone H2AX. Previously we showed that phosphorylation of H2AX (defined as gammaH2AX) in exposed lung cells is proportional to CS dose. Thus, we proposed that gammaH2AX may be a viable biomarker for evaluating genotoxic risk of cigarettes in relation to actual nicotine/tar delivery. Here we tested this hypothesis by measuring gammaH2AX levels in A549 human lung cells exposed to CS from a range of commercial cigarettes using various smoking regimens. Results show that gammaH2AX induction, a critical event of the mammalian DNA damage response, provides an assessment of CS-induced DNA damage independent of smoking topography or cigarette type. We conclude that gammaH2AX induction shows promise as a genotoxic bioassay offering specific advantages over the traditional assays for the evaluation of conventional and nonconventional tobacco products.

  16. The potentially hazardous Asteroid (214869) 2007 PA8: An unweathered L chondrite analog surface

    NASA Astrophysics Data System (ADS)

    Fornasier, S.; Belskaya, I. N.; Perna, D.

    2015-04-01

    In this paper we present the results on the polarimetric and spectroscopic observations of the potentially hazardous Asteroid (214869) 2007 PA8 obtained during its favorable apparition in October-November 2012, when it approached the Earth at the minimal distance of 0.043 AU. Polarimetry was carried out at the NOT in the B, V, R, and I bands covering both low (12-23°) and large phase angles (88-99°). Spectroscopy in the visible and near infrared range was obtained at the TNG telescope. The spectrum of 2007 PA8 shows silicates absorption features and a behavior consistent with a Q-type classification. The olivine and pyroxene BI band is centered at 0.9578 ± 0.0042 μm, with a band depth of 16.5%, the BII band is centered at 1.95 ± 0.01 μm, and it has a band depth of about 3.9%. The 2007 PA8 spectral parameters are consistent with those of L chondrites. Also the spectral comparison with meteorites gives the L-type chondrites, and L6 in particular, as best match. The NEA (214869) 2007 PA8 is the forth moderate albedo asteroid and the first Q-type asteroid for which the value of the polarization maximum is determined. The inversion angle of the polarization curve in the V filter is 19.0 ± 1.1°, the corresponding slope parameter (h) is of 0.078 ± 0.010%/°, the maximum value of polarization is 5.99 ± 0.16%, and the extreme value of negative polarization is estimated to be lower than -0.52%. Using the polarimetric slope we derive a geometric albedo of 0.29 ± 0.08 in the V band, that gives an estimated diameter of 1.4 ± 0.2 km, assuming an absolute Hv magnitude of 16.2 mag. We find a strong dependence of the polarization in the B, V, R, and I bands with wavelength, and the polarimetric albedo in the four bands is strongly correlated with the asteroid's spectrum. The 2007 PA8 polarimetric properties resemble those of other 2 NEAs, 1566 Icarus and 25143 Itokawa, which are both S(IV)/Q type. Our spectral and polarimetric analysis indicate that 2007 PA8 has a young

  17. Oregon Hazard Explorer for Lifelines Program (OHELP): A web-based geographic information system tool for assessing potential Cascadia earthquake hazard

    NASA Astrophysics Data System (ADS)

    Sharifi Mood, M.; Olsen, M. J.; Gillins, D. T.; Javadnejad, F.

    2016-12-01

    The Cascadia Subduction Zone (CSZ) has the ability to generate earthquake as powerful as 9 moment magnitude creating great amount of damage to structures and facilities in Oregon. Series of deterministic earthquake analysis are performed for M9.0, M8.7, M8.4 and M8.1 presenting persistent, long lasting shaking associated with other geological threats such as ground shaking, landslides, liquefaction-induced ground deformations, fault rupture vertical displacement, tsunamis, etc. These ground deformation endangers urban structures, foundations, bridges, roadways, pipelines and other lifelines. Lifeline providers in Oregon, including private and public practices responsible for transportation, electric and gas utilities, water and wastewater, fuel, airports, and harbors face an aging infrastructure that was built prior to a full understanding of this extreme seismic risk. As recently experienced in Chile and Japan, a three to five minutes long earthquake scenario, expected in Oregon, necessities a whole different method of risk mitigation for these major lifelines than those created for shorter shakings from crustal earthquakes. A web-based geographic information system tool is developed to fully assess the potential hazard from the multiple threats impending from Cascadia subduction zone earthquakes in the region. The purpose of this website is to provide easy access to the latest and best available hazard information over the web, including work completed in the recent Oregon Resilience Plan (ORP) (OSSPAC, 2013) and other work completed by the Department of Geology and Mineral Industries (DOGAMI) and the United States Geological Survey (USGS). As a result, this tool is designated for engineers, planners, geologists, and others who need this information to help make appropriate decisions despite the fact that this web-GIS tool only needs minimal knowledge of GIS to work with.

  18. Microbiology & Toxicology: Space Environment

    NASA Image and Video Library

    One key aspect in maintaining crew health and performance during spaceflight missions is the provision of a habitable environment with acceptably low concentrations of microbiological and toxicolog...

  19. IRIS Toxicological Review of Dichloromethane (Methylene ...

    EPA Pesticide Factsheets

    On March 31, 2010, the draft IRIS Toxicological Review of Dichloromethane (Methylene Chloride) external review draft document and the charge to external peer reviewers were released for public review and comment. The draft document and the charge to external peer reviewers were reviewed internally by EPA and by other federal agencies and White House Offices before public release. In the new IRIS process, introduced by the EPA Administrator, all written comments on IRIS assessments submitted by other federal agencies and White House Offices will be made publicly available. Accordingly, interagency comments and the interagency science consultation draft of the Toxicological Review of Dichloromethane (Methylene Chloride) and the charge to external peer reviewers are posted on this site. The draft Toxicological Review of Dichloromethane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to dichloromethane.

  20. Parasites of wild animals as a potential source of hazard to humans.

    PubMed

    Gałęcki, Remigiusz; Sokół, Rajmund; Koziatek, Sylwia

    2015-01-01

    The decline in wild animal habitats and the uncontrolled growth of their population make these animals come closer to human settlements. The aim of the study was to identify parasitic infections in wild animals in the selected area, and to specify the hazards they create for humans. In more than 66% of the analysed faecal samples from wild boar, hares, roe deer, deer and fallow deer various developmental forms of parasites were found. These included parasites dangerous for humans: Toxocara canis, Capillaria hepatica, Capillaria bovis, Trichuris suis, Trichuris ovis, Trichuris globulosus, Eimeria spp., and Trichostongylus spp. It is necessary to monitor parasitic diseases in wild animals as they can lead to the spread of parasites creating a hazard to humans, pets and livestock.

  1. Potential geologic hazards on the eastern Gulf of Cadiz slope (SW Spain)

    USGS Publications Warehouse

    Baraza, J.; Ercilla, G.; Nelson, C.H.

    1999-01-01

    Geologic hazards resulting from sedimentary, oceanographic and tectonic processes affect more than one third of the offshore Gulf of Cadiz, and are identified by interpreting high-resolution seismic profiles and sonographs. Hazards of sedimentary origin include the occurrence of slope instability processes in the form of single or multiple slumps occupying up to 147 km2 mainly concentrated in the steeper, upper slope area. Besides the presence of steep slopes, the triggering of submarine landslides is probably due to seismic activity and favoured by the presence of biogenic gas within the sediment. Gassy sediments and associated seafloor pockmarks cover more than 240 km2 in the upper slope. Hazards from oceanographic processes result from the complex system of bottom currents created by the interaction of the strong Mediterranean Undercurrent and the rough seafloor physiography. The local intensification of bottom currents is responsible for erosive processes along more than 1900 km2 in the upper slope and in the canyons eroded in the central area of the slope, undermining slopes and causing instability. The strong bottom currents also create a mobile seafloor containing bedforms in an area of the Gulf that extends more than 2500 km2, mostly in the continental slope terraces. Hazards of tectonic origin are important because the Gulf of Cadiz straddles two major tectonic regions, the Azores-Gibraltar fracture zone and the Betic range, which results in diapir uplift over an area of more than 1000 km2, and in active seismicity with earthquakes of moderate magnitude. Also, tsunamis produced by strong earthquakes occur in the Gulf of Cadiz, and are related to the tectonic activity along the Azores-Gibraltar fracture zone.

  2. American College of Medical Toxicology

    MedlinePlus

    ... Courses Conference Calendar ACMT at NACCT Seminars in Forensic Toxicology Annual Scientific Meeting Board Review Course Past ... NACCT General Info ACMT Business Meeting Seminars in Forensic Toxicology 2017 Seminar in Forensic Toxicology 2017 Forensic ...

  3. Hazard and potential damage evaluation in a web-gis as support for risk management

    NASA Astrophysics Data System (ADS)

    Frigerio, S.; Sterlacchini, S.; van Westen, C. J.; Akbas, S. O.; Blahut, J.; de Amicis, M.; Sironi, S.

    2009-04-01

    Profiling the potential destructive events that could occur in a study site, inventorying the assets (social and economic features) and estimating the physical effects due to the impacts are the basic issues for defining indicative risk scenarios. Moreover, the necessity of sharing and accessing available information is one of the most important component of risk management. GIS activity, modeling and analysis can improve results and scientific development, but most of end-user and disaster reduction components does not have a high level of this background knowledge. In disaster risk management the capacity of quickly actions for planners, administrators, engineers, end.-users, architects, technicians, etc... is one of the most important matter. For this reason the best way to proceed was the possibility to create user-friendly instruments and devices, based on a geographical platform to share available information and supply requisite activities. In the work it was proposed a CartoWeb solution as a simple and ready-to-use open-source Web-GIS instrument (based on GNU License) as well as a convenient framework for building advanced and customized applications, following the necessity of disaster management experts. It is highly modular, customizable for its object-oriented architecture and based on hierarchical structure (to manage and organize blocks of information of each step required and used in risk assessment). Different switches for every package has been defined and more kind of menu and organization types of data has been structured (susceptibility map and vulnerable element with related data at different scale); for every layer many tools of query, printing, searching and surface analysis are improved, following the necessity to compare maps at different scale and for real-time interpretations. First goal of this activity was the comparison between a traditional GIS system to manage every information and an open source WebGIS platform; an user

  4. Potential tsunamigenic hazard associated to submarine mass movement along the Ionian continental margin (Mediterranean Sea).

    NASA Astrophysics Data System (ADS)

    Ceramicola, S.; Tinti, S.; Praeg, D.; Zaniboni, F.; Planinsek, P.

    2012-04-01

    upper parts of all canyons, numerous headwall scarps are consistent with retrogressive activity of the canyons. 3) possible gravity sliding -elongate seabed features oriented subparallel to contours are observed, associated with diapiric structures suggest that the elongate seabed features may record a form of downslope sediment sliding above salt. The aim of this work is to reconstruct the dynamics of different type of submarine mass movements on the tectonically active Ionian Calabrian margin (ICM), calculate the volume of sediment mobilized and assess the potential tsunamigenic hazard associated to different type of mass movements. Assessments of tsunami arrival time in adjacent coastal areas, period and wavelength of the tsunami and implication for coastal geohazards have been formulated for the Calabrian margin (small scale) and extrapolated to adjacent margins of the Mediterranean basin (large scale).

  5. Link between the potentially hazardous Asteroid (86039) 1999 NC43 and the Chelyabinsk meteoroid tenuous

    NASA Astrophysics Data System (ADS)

    Reddy, Vishnu; Vokrouhlický, David; Bottke, William F.; Pravec, Petr; Sanchez, Juan A.; Gary, Bruce L.; Klima, Rachel; Cloutis, Edward A.; Galád, Adrián; Guan, Tan Thiam; Hornoch, Kamil; Izawa, Matthew R. M.; Kušnirák, Peter; Le Corre, Lucille; Mann, Paul; Moskovitz, Nicholas; Skiff, Brian; Vraštil, Jan

    2015-05-01

    We explored the statistical and compositional link between Chelyabinsk meteoroid and potentially hazardous Asteroid (86039) 1999 NC43 to investigate their proposed relation proposed by Borovička et al. (Borovička, J., et al. [2013]. Nature 503, 235-237). First, using a slightly more detailed computation we confirm that the orbit of the Chelyabinsk impactor is anomalously close to the Asteroid 1999 NC43. We find ∼(1-3) × 10-4 likelihood of that to happen by chance. Taking the standpoint that the Chelyabinsk impactor indeed separated from 1999 NC43 by a cratering or rotational fission event, we run a forward probability calculation, which is an independent statistical test. However, we find this scenario is unlikely at the ∼(10-3-10-2) level. Secondly, we note that efforts to conclusively prove separation of the Chelyabinsk meteoroid from (86039) 1999 NC43 in the past needs to meet severe criteria: relative velocity ≃1-10 m/s or smaller, and ≃100 km distance (i.e. about the Hill sphere distance from the parent body). We conclude that, unless the separation event was an extremely recent event, these criteria present an insurmountable difficulty due to the combination of strong orbital chaoticity, orbit uncertainty and incompleteness of the dynamical model with respect to thermal accelerations. This situation leaves the link of the two bodies unresolved and calls for additional analyses. With that goal, we revisit the presumed compositional link between (86039) 1999 NC43 and the Chelyabinsk body. Borovička et al. (Borovička, J., et al. [2013]. Nature 503, 235-237) noted that given its Q-type taxonomic classification, 1999 NC43 may pass this test. However, here we find that while the Q-type classification of 1999 NC43 is accurate, assuming that all Q-types are LL chondrites is not. Our experiment shows that not all ordinary chondrites fall under Q-taxonomic type and not all LL chondrites are Q-types. Spectral curve matching between laboratory spectra of

  6. The potential monetary benefits of reclaiming hazardous waste sites in the Campania region: an economic evaluation.

    PubMed

    Guerriero, Carla; Cairns, John

    2009-06-24

    Evaluating the economic benefit of reducing negative health outcomes resulting from waste management is of pivotal importance for designing an effective waste policy that takes into account the health consequences for the populations exposed to environmental hazards. Despite the high level of Italian and international media interest in the problem of hazardous waste in Campania little has been done to reclaim the land and the waterways contaminated by hazardous waste. This study aims to reduce the uncertainty about health damage due to waste exposure by providing for the first time a monetary valuation of health benefits arising from the reclamation of hazardous waste dumps in Campania. First the criteria by which the landfills in the Campania region, in particular in the two provinces of Naples and Caserta, have been classified are described. Then, the annual cases of premature death and fatal cases of cancers attributable to waste exposure are quantified. Finally, the present value of the health benefits from the reclamation of polluted land is estimated for each of the health outcomes (premature mortality, fatal cancer and premature mortality adjusted for the cancer premium). Due to the uncertainty about the time frame of the benefits arising from reclamation, the latency of the effects of toxic waste on human health and the lack of context specific estimates of the Value of Preventing a Fatality (VPF), extensive sensitivity analyses are performed. There are estimated to be 848 cases of premature mortality and 403 cases of fatal cancer per year as a consequence of exposure to toxic waste. The present value of the benefit of reducing the number of waste associated deaths after adjusting for a cancer premium is euro11.6 billion. This value ranges from euro5.4 to euro20.0 billion assuming a time frame for benefits of 10 and 50 years respectively. This study suggests that there is a strong economic argument for both reclaiming the land contaminated with hazardous

  7. The potential monetary benefits of reclaiming hazardous waste sites in the Campania region: an economic evaluation

    PubMed Central

    2009-01-01

    Background Evaluating the economic benefit of reducing negative health outcomes resulting from waste management is of pivotal importance for designing an effective waste policy that takes into account the health consequences for the populations exposed to environmental hazards. Despite the high level of Italian and international media interest in the problem of hazardous waste in Campania little has been done to reclaim the land and the waterways contaminated by hazardous waste. Objective This study aims to reduce the uncertainty about health damage due to waste exposure by providing for the first time a monetary valuation of health benefits arising from the reclamation of hazardous waste dumps in Campania. Methods First the criteria by which the landfills in the Campania region, in particular in the two provinces of Naples and Caserta, have been classified are described. Then, the annual cases of premature death and fatal cases of cancers attributable to waste exposure are quantified. Finally, the present value of the health benefits from the reclamation of polluted land is estimated for each of the health outcomes (premature mortality, fatal cancer and premature mortality adjusted for the cancer premium). Due to the uncertainty about the time frame of the benefits arising from reclamation, the latency of the effects of toxic waste on human health and the lack of context specific estimates of the Value of Preventing a Fatality (VPF), extensive sensitivity analyses are performed. Results There are estimated to be 848 cases of premature mortality and 403 cases of fatal cancer per year as a consequence of exposure to toxic waste. The present value of the benefit of reducing the number of waste associated deaths after adjusting for a cancer premium is €11.6 billion. This value ranges from €5.4 to €20.0 billion assuming a time frame for benefits of 10 and 50 years respectively. Conclusion This study suggests that there is a strong economic argument for both

  8. The Prevalence of Selected Potentially Hazardous Workplace Exposures in the US: Findings From the 2010 National Health Interview Survey

    PubMed Central

    Calvert, Geoffrey M.; Luckhaupt, Sara E.; Sussell, Aaron; Dahlhamer, James M.; Ward, Brian W.

    2015-01-01

    Objective Assess the national prevalence of current workplace exposure to potential skin hazards, secondhand smoke (SHS), and outdoor work among various industry and occupation groups. Also, assess the national prevalence of chronic workplace exposure to vapors, gas, dust, and fumes (VGDF) among these groups. Methods Data were obtained from the 2010 National Health Interview Survey (NHIS). NHIS is a multistage probability sample survey of the civilian non-institutionalized population of the US. Prevalence rates and their variances were calculated using SUDAAN to account for the complex NHIS sample design. Results The data for 2010 were available for 17,524 adults who worked in the 12 months that preceded interview. The highest prevalence rates of hazardous workplace exposures were typically in agriculture, mining, and construction. The prevalence rate of frequent handling of or skin contact with chemicals, and of non-smokers frequently exposed to SHS at work was highest in mining and construction. Outdoor work was most common in agriculture (85%), construction (73%), and mining (65%). Finally, frequent occupational exposure to VGDF was most common among mining (67%), agriculture (53%), and construction workers (51%). Conclusion We identified industries and occupations with the highest prevalence of potentially hazardous workplace exposures, and provided targets for investigation and intervention activities. PMID:22821700

  9. Potential carcinogenic hazards of non-regulated disinfection by-products: haloquinones, halo-cyclopentene and cyclohexene derivatives, N-halamines, halonitriles, and heterocyclic amines.

    PubMed

    Bull, Richard J; Reckhow, David A; Li, Xingfang; Humpage, Andrew R; Joll, Cynthia; Hrudey, Steve E

    2011-08-15

    biological properties of concern, but no member has ever been characterized toxicologically beyond bacterial or in vitro studies of genotoxicity. The documented formation of several nitrosamines from secondary amines from both natural and industrial sources prompted exploration of the formation of additional nitrosamines. N-diphenylnitrosamine was identified in drinking waters. Of more interest, however, was the formation of phenazine (and subsequently N-chorophenazine) in a competing reaction. These are the first heterocyclic amines that have been identified as chlorination by-products. Consideration of the amounts detected of members of these by-product classes and their probable toxicological potency suggest a prioritization for obtaining more detailed toxicological data of HQs>HCP&H derivatives>NCls>HNs. Based upon a ubiquitous occurrence and virtual lack of in vivo toxicological data, NCls are the most difficult group to assign a priority as potential carcinogenic risks. This analysis indicates that research on the general problem of DBPs requires a more systematic approach than has been pursued in the past. Utilization of predictive chemical tools to guide further research can help bring resolution to the DBP issue by identifying likely DBPs with high toxicological potency.

  10. Toxicology and safety of DHA.

    PubMed

    Lien, Eric L

    2009-01-01

    Docosahexaenoic acid (DHA) is a long-chain polyunsaturated fatty acid with activities in both infants and adults. The objective of the current work was to evaluate the published literature concerning the toxicological assessment of DHA-rich oils in animals and the safety profile of DHA consumption in humans. Structured literature searches concerning DHA toxicology and DHA effects on platelet function, lipid levels, oxidative potential, glycemic control, and immune function were conducted. The toxicological profile of DHA derived from single-cell organisms demonstrates that these oils are safe in rats (up to a consumption level of 3290 mg/kg body weight/d) in 90-d toxicology evaluations, as well as in reproductive and developmental toxicology studies. The maximum DHA level in human breast milk exceeds 1% of total fatty acids in high-fish-consuming populations. Consumption of DHA-rich human milk as sole source of nutrition provides approximately 315 mg/d in infants 1-6 months of age, and appears to be a safe level of intake. DHA supplementation studies in adults have employed doses ranging from less than 1 to 7.5 g/d, and have not resulted in any consistent adverse responses in platelet function, lipid levels, in vivo oxidation parameters, glycemic control, or immune function. In conclusion, DHA consumption does not result in consistent adverse events in infants or adults. Safe intake levels may be modeled on DHA intake from human milk in infants, and may be at least as high as the upper doses studied in adults.

  11. A decision analysis framework for estimating the potential hazards for drinking water resources of chemicals used in hydraulic fracturing fluids.

    PubMed

    Yost, Erin E; Stanek, John; Burgoon, Lyle D

    2017-01-01

    Despite growing concerns over the potential for hydraulic fracturing to impact drinking water resources, there are limited data available to identify chemicals used in hydraulic fracturing fluids that may pose public health concerns. In an effort to explore these potential hazards, a multi-criteria decision analysis (MCDA) framework was employed to analyze and rank selected subsets of these chemicals by integrating data on toxicity, frequency of use, and physicochemical properties that describe transport in water. Data used in this analysis were obtained from publicly available databases compiled by the United States Environmental Protection Agency (EPA) as part of a larger study on the potential impacts of hydraulic fracturing on drinking water. Starting with nationwide hydraulic fracturing chemical usage data from EPA's analysis of the FracFocus Chemical Disclosure Registry 1.0, MCDAs were performed on chemicals that had either noncancer toxicity values (n=37) or cancer-specific toxicity values (n=10). The noncancer MCDA was then repeated for subsets of chemicals reported in three representative states (Texas, n=31; Pennsylvania, n=18; and North Dakota, n=20). Within each MCDA, chemicals received scores based on relative toxicity, relative frequency of use, and physicochemical properties (mobility in water, volatility, persistence). Results show a relative ranking of these chemicals based on hazard potential, and provide preliminary insight into chemicals that may be more likely than others to impact drinking water resources. Comparison of nationwide versus state-specific analyses indicates regional differences in the chemicals that may be of more concern to drinking water resources, although many chemicals were commonly used and received similar overall hazard rankings. Several chemicals highlighted by these MCDAs have been reported in groundwater near areas of hydraulic fracturing activity. This approach is intended as a preliminary analysis, and represents one

  12. Non-precautionary aspects of toxicology

    SciTech Connect

    Grandjean, Philippe . E-mail: pgrand@health.sdu.dk

    2005-09-01

    Empirical studies in toxicology aim at deciphering complex causal relationships, especially in regard to human disease etiologies. Several scientific traditions limit the usefulness of documentation from current toxicological research, in regard to decision-making based on the precautionary principle. Among non-precautionary aspects of toxicology are the focus on simplified model systems and the effects of single hazards, one by one. Thus, less attention is paid to sources of variability and uncertainty, including individual susceptibility, impacts of mixed and variable exposures, susceptible life-stages, and vulnerable communities. In emphasizing the need for confirmatory evidence, toxicology tends to penalize false positives more than false negatives. An important source of uncertainty is measurement error that results in misclassification, especially in regard to exposure assessment. Standard statistical analysis assumes that the exposure is measured without error, and imprecisions will usually result in an underestimation of the dose-effect relationship. In testing whether an effect could be considered a possible result of natural variability, a 5% limit for 'statistical significance' is usually applied, even though it may rule out many findings of causal associations, simply because the study was too small (and thus lacked statistical power) or because some imprecision or limited sensitivity of the parameters precluded a more definitive observation. These limitations may be aggravated when toxicology is influenced by vested interests. Because current toxicology overlooks the important goal of achieving a better characterization of uncertainties and their implications, research approaches should be revised and strengthened to counteract the innate ideological biases, thereby supporting our confidence in using toxicology as a main source of documentation and in using the precautionary principle as a decision procedure in the public policy arena.

  13. Toxicological Concerns of Engineered Nanosize Drug Delivery Systems.

    PubMed

    Mukherjee, Biswajit; Maji, Ruma; Roychowdhury, Samrat; Ghosh, Saikat

    2016-01-01

    Matters when converted into nanosize provide some unique surface properties, which are different from those of the bulk materials. Nanomaterials show some extraordinary behavioral patterns because of those properties, such as supermagnetism, quantum confinement, etc. A great deal of implication of nanomaterials in nanomedicine has already been realized. Utility of nanomaterials as drug nanocarrier projects many potential advantages of them in drug delivery. Despite many such advantages, the potential risk of health and environmental hazards related to them cannot be ignored. Here various physicochemical factors, such as chemical nature, degradability, surface properties, surface charge, particle size, and shape, have been shown to play a crucial role in toxicity related to drug nanocarriers. Evidence-based findings of some drug nanocarriers have been incorporated to provide distinct knowledge to the readers in the field. A glimpse of current regulatory controls and measures required to combat the challenges of toxicological aspects of drug nanocarriers have been described.

  14. Risk assessment and toxicology databases for health effects assessment

    SciTech Connect

    Lu, P.Y.; Wassom, J.S.

    1990-12-31

    Scientific and technological developments bring unprecedented stress to our environment. Society has to predict the results of potential health risks from technologically based actions that may have serious, far-reaching consequences. The potential for error in making such predictions or assessment is great and multiplies with the increasing size and complexity of the problem being studied. Because of this, the availability and use of reliable data is the key to any successful forecasting effort. Scientific research and development generate new data and information. Much of the scientific data being produced daily is stored in computers for subsequent analysis. This situation provides both an invaluable resource and an enormous challenge. With large amounts of government funds being devoted to health and environmental research programs and with maintenance of our living environment at stake, we must make maximum use of the resulting data to forecast and avert catastrophic effects. Along with the readily available. The most efficient means of obtaining the data necessary for assessing the health effects of chemicals is to utilize applications include the toxicology databases and information files developed at ORNL. To make most efficient use of the data/information that has already been prepared, attention and resources should be directed toward projects that meticulously evaluate the available data/information and create specialized peer-reviewed value-added databases. Such projects include the National Library of Medicine`s Hazardous Substances Data Bank, and the U.S. Air Force Installation Restoration Toxicology Guide. These and similar value-added toxicology databases were developed at ORNL and are being maintained and updated. These databases and supporting information files, as well as some data evaluation techniques are discussed in this paper with special focus on how they are used to assess potential health effects of environmental agents. 19 refs., 5 tabs.

  15. Toxicological benchmark for screening of potential contaminants of concern for effects on aquatic biota on the Oak Ridge Reservation, Oak Ridge, Tennessee; Environmental Restoration Program

    SciTech Connect

    Suter, G.W. II; Futrell, M.A.; Kerchner, G.A.

    1992-09-01

    One of the initial stages in ecological risk assessment of hazardous waste sites is the screening of contaminants to determine which of them are worthy of further consideration. This report presents potential screening benchmarks for protection of aquatic life from contaminants in water. Because there is no guidance for screening benchmarks, a set of alternative benchmarks is presented here. The alternative benchmarks are based on different conceptual approaches to estimating concentrations causing significant effects. To the extent that toxicity data are available, this report presents the alternative benchmarks for chemicals that have been detected on the Oak Ridge Reservation. It also presents the data used to calculate the benchmarks, and the sources of the data. It compares the benchmarks and discusses their relative conservatism and utility.

  16. Proteomics for systems toxicology

    PubMed Central

    Titz, Bjoern; Elamin, Ashraf; Martin, Florian; Schneider, Thomas; Dijon, Sophie; Ivanov, Nikolai V.; Hoeng, Julia; Peitsch, Manuel C.

    2014-01-01

    Current toxicology studies frequently lack measurements at molecular resolution to enable a more mechanism-based and predictive toxicological assessment. Recently, a systems toxicology assessment framework has been proposed, which combines conventional toxicological assessment strategies with system-wide measurement methods and computational analysis approaches from the field of systems biology. Proteomic measurements are an integral component of this integrative strategy because protein alterations closely mirror biological effects, such as biological stress responses or global tissue alterations. Here, we provide an overview of the technical foundations and highlight select applications of proteomics for systems toxicology studies. With a focus on mass spectrometry-based proteomics, we summarize the experimental methods for quantitative proteomics and describe the computational approaches used to derive biological/mechanistic insights from these datasets. To illustrate how proteomics has been successfully employed to address mechanistic questions in toxicology, we summarized several case studies. Overall, we provide the technical and conceptual foundation for the integration of proteomic measurements in a more comprehensive systems toxicology assessment framework. We conclude that, owing to the critical importance of protein-level measurements and recent technological advances, proteomics will be an integral part of integrative systems toxicology approaches in the future. PMID:25379146

  17. Educational Challenges in Toxicology.

    ERIC Educational Resources Information Center

    Dixon, Robert L.

    1984-01-01

    Issues and topics related to educational challenges in toxicology at all levels are discussed. They include public awareness and understanding, general approach to toxicology, quality structure-activity relationships, epidemiological studies, quantification of risk, and the types of toxicants studied. (JN)

  18. Toxicology and risk assessment information resources for librarians.

    PubMed

    Stirling, D A

    2000-01-01

    Many librarians work with toxicologists and risk assessors seeking information about chemicals and hazardous substances of concern to human health and the environment. Therefore, this article reviews reliable, accurate, readily accessible, and user-friendly sources of toxicological and risk assessment information. A summary and description of pertinent toxicological data, literature, and profile sources is presented. The majority of the resources are available online; however, descriptions of several important print sources are included.

  19. IRIS Toxicological Review of Trichloroacetic Acid (Tca) (Final ...

    EPA Pesticide Factsheets

    EPA has finalized the Toxicological Review of Trichloroacetic Acid: in support of the Integrated Risk Information System (IRIS). Now final, this assessment may be used by EPA’s program and regional offices to inform decisions to protect human health. The draft Toxicological Review of Trichloroacetic Acid provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to trichloroacetic acid.

  20. A UK scheme to help small firms control health risks from chemicals: toxicological considerations.

    PubMed

    Brooke, I M

    1998-08-01

    The UK has developed a simple scheme to provide practical control advice to small and medium-sized enterprises (SMEs), to assist them in their risk assessments and risk management decisions. This scheme makes use of toxicological hazard information indicated by R-phrases assigned under the European Union (EU) classification system, to assign substances to hazard bands. In the UK scheme, the allocation of substances to hazard bands according to R-phrases has taken into account three key factors: whether or not the toxicological endpoint has an identifiable dose threshold; the seriousness of the resultant health effect; and the relative exposure levels at which toxic effects occur. Based on all these considerations, R-phrases have been allocated to hazard bands within the scheme. An evaluation exercise has been undertaken, to compare the output of the scheme with established health-based occupational exposure limits, for more than 100 substances. The results of this exercise demonstrate that as far as possible, the scheme recommends control strategies which should provide adequate control. This scheme is potentially a very powerful means of helping SMEs adequately control chemical health risks in the workplace. Since it utilises the EU-agreed classification system, the scheme can be applied to any substance supplied and used in the workplace and it may also be used internationally.

  1. Respiratory symptoms among glass bottle makers exposed to stannic chloride solution and other potentially hazardous substances

    SciTech Connect

    Levy, B.S.; Davis, F.; Johnson, B.

    1985-04-01

    Concern about upper respiratory tract irritation and other symptoms among workers at a glass bottle manufacturing plant led to an epidemiologic and an industrial hygiene survey. Questionnaire responses from 35 hot end and 53 cold end workers indicated that the incidence of wheezing, chest pain, dyspnea on exertion, and cough was significantly elevated among hot end workers. Among both smokers and nonsmokers, hot end workers reported higher, but not significantly higher, rates of wheezing and chest pain. Among smokers, hot end workers reported significantly higher rates of dyspnea on exertion and cough than did cold end workers. Data suggest that reported exposure to stannic chloride solution likely caused these symptoms. The industrial hygiene survey, conducted when stannic chloride use had been reduced, cleaning had been done, and ventilation improved, focused on measuring air contaminants that might possibly cause symptoms. Levels of hydrogen chloride, which apparently was formed by the combination of stannic chloride and water in the presence of heat, were elevated. The finding of increased prevalence of respiratory symptoms among hot end workers was consistent with this exposure. Recommendations were made to reduce hazardous exposures at this plant. Individuals responsible for occupational health should be aware that relatively benign substances, such as stannic chloride and water, can combine spontaneously to form hazardous substances.

  2. Potential hazards from floodflows in Grapevine Canyon, Death Valley National Monument, California and Nevada

    USGS Publications Warehouse

    Bowers, J.C.

    1990-01-01

    Grapevine Canyon is on the western slope of the Grapevine Mountains in the northern part of Death Valley National Monument , California and Nevada. Grapevine Canyon Road covers the entire width of the canyon floor in places and is a frequently traveled route to Scotty 's Castle in the canyon. The region is arid and subject to flash flooding because of infrequent but intense convective storms. When these storms occur, normally in the summer, the resulting floods may create a hazard to visitor safety and property. Historical data on rainfall and floodflow in Grapevine Canyon are sparse. Data from studies made for similar areas in the desert mountains of southern California provide the basis for estimating discharges and the corresponding frequency of floods in the study area. Results of this study indicate that high-velocity flows of water and debris , even at shallow depths, may scour and damage Grapevine Canyon Road. When discharge exceeds 4,900 cu ft/sec, expected at a recurrence interval of between 25 and 50 years, the Scotty 's Castle access road and bridge may be damaged and the parking lot partly inundated. A flood having a 100-year or greater recurrence interval probably would wash out the bridge and present a hazard to the stable and garage buildings but not to the castle buildings, whose foundations are higher than the predicted maximum flood level. (USGS)

  3. Ferns and lycopods--a potential treasury of anticancer agents but also a carcinogenic hazard.

    PubMed

    Tomšík, Pavel

    2014-06-01

    Many species of seedless vascular plants-ferns and lycopods-have been used as food and folk medicine since ancient times. Some of them have become the focus of intensive research concerning their anticancer properties. Studies on the anticancer effect of crude extracts are being increasingly replaced by bioactivity-guided fractionation, as well as detailed assessment of the mechanism of action. Numerous compounds-especially flavonoids such as amentoflavone and protoapigenone, and also simpler phenolic compounds, steroids, alkaloids and terpenoids-were isolated and found to be cytotoxic, particularly pro-apoptotic, or to induce cell cycle arrest in cancer cell lines in vitro. In in vivo experiments, some fern-derived compounds inhibited tumour growth with little toxicity. On the other hand, many ferns-not only the well-known Bracken (Pteridium)-may pose a significant hazard to human health due to the fact that they contain carcinogenic sesquiterpenoids and their analogues. The objective of this review is to summarise the recent state of research on the anticancer properties of ferns and lycopods, with a focus on their characteristic bioactive constituents. The carcinogenic hazard posed by ferns is also mentioned.

  4. Ranking the potential carcinogenic hazards to workers from exposures to chemicals that are tumorigenic in rodents.

    PubMed Central

    Gold, L S; Backman, G M; Hooper, N K; Peto, R

    1987-01-01

    For 41 chemicals there exist both reasonable data on carcinogenic potency in experimental animals and also a defined Permissible Exposure Level (PEL), which is the upper limit of legally permissible chronic occupational exposure for U.S. workers. These 41 agents are ranked by an index that compares the permitted chronic human exposure to the chronic dose rate that induces tumors in 50% of laboratory animals. This index, the Permitted Exposure/Rodent Potency index, or PERP, does not estimate absolute risks directly, but rather suggests the relative hazards that such substances may pose. The PERP values for these 41 substances differ by more than 100,000-fold from each other. The PERP does not take into account the actual level of exposure or the number of exposed workers. Nevertheless, it might be reasonable to give priority attention to the reduction of allowable worker exposures to substances that appear most hazardous by this index and that some workers may be exposed to full-time near the PEL. Ranked by PERP, these chemicals are: ethylene dibromide, ethylene dichloride, 1,3-butadiene, tetrachloroethylene, propylene oxide, chloroform, formaldehyde, methylene chloride, dioxane, and benzene. PMID:3447901

  5. A brief overview of the 33rd Annual STP Symposium on the translational pathology: relevance of toxicologic pathology to human health.

    PubMed

    Hoenerhoff, Mark J; Silverman, Lee; Francke, Sabine

    2015-01-01

    The 33rd Society of Toxicologic Pathology's Annual Symposium focused on translational science and the relevance of toxicologic pathology to human health. Toxicologic pathologists work in diverse settings studying changes elicited by pharmacological, chemical, and environmental agents and factors that modify these responses. Regardless of the work setting, society members are dedicated to the integration of toxicologic pathology into hazard identification, risk assessment, and risk communication regarding human and animal exposure to potentially toxic substances. Toxicologic pathologists routinely face not only questions regarding pathological changes related to compound exposure but also questions concerning what translational relevance those lesions and exposures have to a human population or organ system. This symposium provided a basis for the membership to understand the variety of roles the toxicologic pathologist plays in translational science, where our gaps in translational science are, and how we can move forward to better address the challenges in the field translational science in order to continue to positively impact human health. © 2014 by The Author(s).

  6. Mycotoxins: occurrence, toxicology, and exposure assessment.

    PubMed

    Marin, S; Ramos, A J; Cano-Sancho, G; Sanchis, V

    2013-10-01

    Mycotoxins are abiotic hazards produced by certain fungi that can grow on a variety of crops. Consequently, their prevalence in plant raw materials may be relatively high. The concentration of mycotoxins in finished products is usually lower than in raw materials. In this review, occurrence and toxicology of the main mycotoxins are summarised. Furthermore, methodological approaches for exposure assessment are described. Existing exposure assessments, both through contamination and consumption data and biomarkers of exposure, for the main mycotoxins are also discussed.

  7. Space Toxicology: Human Health during Space Operations

    NASA Technical Reports Server (NTRS)

    Khan-Mayberry, Noreen; James, John T.; Tyl, ROchelle; Lam, Chiu-Wing

    2010-01-01

    Space Toxicology is a unique and targeted discipline for spaceflight, space habitation and occupation of celestial bodies including planets, moons and asteroids. Astronaut explorers face distinctive health challenges and limited resources for rescue and medical care during space operation. A central goal of space toxicology is to protect the health of the astronaut by assessing potential chemical exposures during spaceflight and setting safe limits that will protect the astronaut against chemical exposures, in a physiologically altered state. In order to maintain sustained occupation in space on the International Space Station (ISS), toxicological risks must be assessed and managed within the context of isolation continuous exposures, reuse of air and water, limited rescue options, and the need to use highly toxic compounds for propulsion. As we begin to explore other celestial bodies in situ toxicological risks, such as inhalation of reactive mineral dusts, must also be managed.

  8. Techniques for Investigating Molecular Toxicology of Nanomaterials.

    PubMed

    Wang, Yanli; Li, Chenchen; Yao, Chenjie; Ding, Lin; Lei, Zhendong; Wu, Minghong

    2016-06-01

    Nanotechnology has been a rapidly developing field in the past few decades, resulting in the more and more exposure of nanomaterials to human. The increased applications of nanomaterials for industrial, commercial and life purposes, such as fillers, catalysts, semiconductors, paints, cosmetic additives and drug carriers, have caused both obvious and potential impacts on human health and environment. Nanotoxicology is used to study the safety of nanomaterials and has grown at the historic moment. Molecular toxicology is a new subdiscipline to study the interactions and impacts of materials at the molecular level. To better understand the relationship between the molecular toxicology and nanomaterials, this review summarizes the typical techniques and methods in molecular toxicology which are applied when investigating the toxicology of nanomaterials and include six categories: namely; genetic mutation detection, gene expression analysis, DNA damage detection, chromosomal aberration analysis, proteomics, and metabolomics. Each category involves several experimental techniques and methods.

  9. Potential submarine geologic hazards at the entrance of the Pearl River Estuary in the northern South China Sea

    NASA Astrophysics Data System (ADS)

    Zhang, Zhiqiang; Wei, Zhiqiang; He, Huizhong; Wei, Wei; Qian, Libing; Li, Tuanjie

    2016-08-01

    The potential submarine geologic hazards were distinguished and categorized at the entrance of the Pearl River Estuary in the northern South China Sea, based upon the analysis of side scan sonar and sub-bottom profiler surveying data of about 2500 km long, in an area about 2000 km2 around the Wanshan Archipelago. The data obtained in the survey has the highest spatial resolution by far, which could reveal more detailed distributions and characteristics of the geologic hazards than before. In the study region, three paleo-channels that were buried about 10-30 m below the seabed were found; more than 10 shallow gas areas were discovered. The sand waves found in the region were generally small and located near the islands, and twenty pockmarks found on the seabed were mostly concentrated to north of Zhuzhou island. There are also many man-made obstacles in the region, such as wreckages, pipeline, etc. In this paper we provide a detailed distribution map of the submarine geologic hazards in this region for the first time, and discuss their formation and harmfulness, which will provide a scientific basis for marine engineering construction, marine geologic disaster prevention and mitigation.

  10. Community exposure to potential climate-driven changes to coastal-inundation hazards for six communities in Essex County, Massachusetts

    USGS Publications Warehouse

    Abdollahian, Nina; Ratliff, Jamie L.; Wood, Nathan J.

    2016-11-09

    IntroductionUnderstanding if and how community exposure to coastal hazards may change over time is crucial information for coastal managers tasked with developing climate adaptation plans. This report summarizes estimates of population and asset exposure to coastal-inundation hazards associated with sea-level-rise and storm scenarios in six coastal communities of the Great Marsh region of Essex County, Massachusetts. This U.S. Geological Survey (USGS) analysis was conducted in collaboration with National Wildlife Federation (NWF) representatives, who are working with local stakeholders to develop local climate adaptation plans for the Towns of Salisbury, Newbury, Rowley, Ipswich, and Essex and the City of Newburyport (hereafter referred to as communities). Community exposure was characterized by integrating various community indicators (land cover and land use, population, economic assets, critical facilities, and infrastructure) with coastal-hazard zones that estimate inundation extents and water depth for three time periods.Estimates of community exposure are based on the presence of people, businesses, and assets in hazard zones that are calculated from geospatial datasets using geographic-information-system (GIS) tools. Results are based on current distributions of people and assets in hazard zones and do not take into account projections of human population, asset, or land-use changes over time. Results are not loss estimates based on engineering analysis or field surveys for any particular facility and do not take into account aspects of individual and household preparedness before an extreme event, adaptive capacity of a community during an event, or long-term resilience of individuals and communities after an event. Potential losses would match reported inventories only if all residents, business owners, public managers, and elected officials were unaware of what to do if warned of an imminent threat, failed to take protective measures during an extreme

  11. Hazardous Compounds in Tobacco Smoke

    PubMed Central

    Talhout, Reinskje; Schulz, Thomas; Florek, Ewa; van Benthem, Jan; Wester, Piet; Opperhuizen, Antoon

    2011-01-01

    Tobacco smoke is a toxic and carcinogenic mixture of more than 5,000 chemicals. The present article provides a list of 98 hazardous smoke components, based on an extensive literature search for known smoke components and their human health inhalation risks. An electronic database of smoke components containing more than 2,200 entries was generated. Emission levels in mainstream smoke have been found for 542 of the components and a human inhalation risk value for 98 components. As components with potential carcinogenic, cardiovascular and respiratory effects have been included, the three major smoke-related causes of death are all covered by the list. Given that the currently used Hoffmann list of hazardous smoke components is based on data from the 1990s and only includes carcinogens, it is recommended that the current list of 98 hazardous components is used for regulatory purposes instead. To enable risk assessment of components not covered by this list, thresholds of toxicological concern (TTC) have been established from the inhalation risk values found: 0.0018 μg day−1 for all risks, and 1.2 μg day−1 for all risks excluding carcinogenicity, the latter being similar to previously reported inhalation TTCs. PMID:21556207

  12. Food for thought ... A toxicology ontology roadmap.

    PubMed

    Hardy, Barry; Apic, Gordana; Carthew, Philip; Clark, Dominic; Cook, David; Dix, Ian; Escher, Sylvia; Hastings, Janna; Heard, David J; Jeliazkova, Nina; Judson, Philip; Matis-Mitchell, Sherri; Mitic, Dragana; Myatt, Glenn; Shah, Imran; Spjuth, Ola; Tcheremenskaia, Olga; Toldo, Luca; Watson, David; White, Andrew; Yang, Chihae

    2012-01-01

    Foreign substances can have a dramatic and unpredictable adverse effect on human health. In the development of new therapeutic agents, it is essential that the potential adverse effects of all candidates be identified as early as possible. The field of predictive toxicology strives to profile the potential for adverse effects of novel chemical substances before they occur, both with traditional in vivo experimental approaches and increasingly through the development of in vitro and computational methods which can supplement and reduce the need for animal testing. To be maximally effective, the field needs access to the largest possible knowledge base of previous toxicology findings, and such results need to be made available in such a fashion so as to be interoperable, comparable, and compatible with standard toolkits. This necessitates the development of open, public, computable, and standardized toxicology vocabularies and ontologies so as to support the applications required by in silico, in vitro, and in vivo toxicology methods and related analysis and reporting activities. Such ontology development will support data management, model building, integrated analysis, validation and reporting, including regulatory reporting and alternative testing submission requirements as required by guidelines such as the REACH legislation, leading to new scientific advances in a mechanistically-based predictive toxicology. Numerous existing ontology and standards initiatives can contribute to the creation of a toxicology ontology supporting the needs of predictive toxicology and risk assessment. Additionally, new ontologies are needed to satisfy practical use cases and scenarios where gaps currently exist. Developing and integrating these resources will require a well-coordinated and sustained effort across numerous stakeholders engaged in a public-private partnership. In this communication, we set out a roadmap for the development of an integrated toxicology ontology

  13. Hazard Assessment of Glacial Lake Outburst Flood and Potential of ICTs for Coping: A Case of Eastern Himalaya of Nepal

    NASA Astrophysics Data System (ADS)

    Bhattarai, D. R.; Pradhananga, D.

    2014-12-01

    Alarming rate of retreat of glaciers and formation of glacial lakes in higher elevation of Nepal Himalaya has been reported to be related with the pronounced atmospheric temperature rise in the region. Glacier Lake Outburst Floods (GLOF) are the growing climate induced hazards in the Himalaya increasing the vulnerability of community living in the mountain valley, and the fragile ecosystem. This study tried to come up with the potential impacts from glacial lake outburst flood (GLOF) in highland of eastern region of Nepal and potential role of Information Communication Technologies (ICT) in coping. I analyzed the trend of climatic pattern (temperature and precipitation) of the Eastern Himalaya Region of Nepal available from Department of Hydrology and Meteorology (DHM), Government of Nepal, and also prepared the latest location map of the glacial lakes using google earth and ArcGIS application in the highland of the Kanchanjungha Conservation Area of the region. Tiptala glacial lake, located at an elevation of 4950 masl, within the conservation area, was selected for the GLOF hazard assessment. I used semi-structured questioner survey and key informants interviews in the community living below the lake in the highland of the study area in order to assess the potential hazard of GLOF. Analysis shows the increasing trend of atmospheric temperature in the region. With the varying sizes, 46 glacial lakes were located in the region, which covers over 2.57 sq. km in total. Though the larger portion of the downstream area of the Tiptala glacial lake fall in the remote location away from major residential area, few villages, major pasture lands for Yaks, foot trails, and several bridges across the Tamor River below the lake are in risk of GLOF. Poor access due to extreme geographical remoteness and capacity to afford the modern technologies in the community is seen as the major limiting factor to the knowledge and information about the climate change and related impacts

  14. Solutions Network Formulation Report. NASA's Potential Contributions using ASTER Data in Marine Hazard Mitigation

    NASA Technical Reports Server (NTRS)

    Fletcher, Rose

    2010-01-01

    The 28-foot storm surge from Hurricane Katrina pushed inland along bays and rivers for a distance of 12 miles in some areas, contributing to the damage or destruction of about half of the fleet of boats in coastal Mississippi. Most of those boats had sought refuge in back bays and along rivers. Some boats were spared damage because the owners chose their mooring site well. Gulf mariners need a spatial analysis tool that provides guidance on the safest places to anchor their boats during future hurricanes. This product would support NOAA s mission to minimize the effects of coastal hazards through awareness, education, and mitigation strategies and could be incorporated in the Coastal Risk Atlas decision support tool.

  15. [Accidental ingestion of tobacco products by children and awareness by guardians of the hazard potential].

    PubMed

    Yokota, Itsuko; Tsurusaki, Kenichi; Sugihara, Narumi

    2008-04-01

    The actual state of the accidental ingestion of tobacco products by children and awareness of guardians against its hazards were investigated through a survey among guardians of kindergartenaged children. Self-reporting questionnaires were distributed to the guardians of children enrolled in nurseries and kindergartens in cities located in eastern Hiroshima prefecture. Responses of 417 guardians (response rate, 80.5%) were analyzed. The total number of children was reported to be 796 (429 boys, 366 girls, 1 gender unreported) of which 72.2% were under 6 years of age. Based on the survey, 54.4% of fathers and 12.2% of mothers were smokers. Taking into account the presence of other smoking adults such as grandparents, the percentage of families with smokers was 64.3%. Accidental ingestion of tobacco products and the rate including attempted ingestion of tobacco were reported in 15.7% and 28.7% of the families with smokers, respectively. With regard to storage of tobacco and ashtrays, 36.2% of the families with smokers did not store these out of the reach of children, and 7.5% were unaware of the need for a separate storage area. Only 50% of the guardians were aware of the hazards of nicotine exudates. 84.0% of the families with smokers agreed that children should be protected from passive smoking for maintaining good health and growth. However, only 25.0% of the families with smokers had a guardians who actually protected children from passive smoking. The results of the survey indicated that 64.3% of families with preschool-age children had smoking members. Tobacco products were not appropriately stored out of the reach of children. Moreover, several cases of accidental ingestion of tobacco products by children had occurred in families with smokers. Furthermore, it was indicated that many children were exposed to passive smoking, although most guardians were aware of its risks.

  16. Potential hazard of hearing damage to students in undergraduate popular music courses.

    PubMed

    Barlow, Christopher

    2010-12-01

    In recent years, there has been a rapid growth in university courses related to popular and commercial music, with a commensurate increase in the number of students studying these courses. Students of popular music subjects are frequently involved in the use of electronically amplified sound for rehearsal and recording, in addition to the "normal" noise exposure commonly associated with young people. The combination of these two elements suggests a higher than average noise exposure hazard for these students. To date, the majority of noise studies on students have focused on exposure from personal music players and on classical, orchestral, and marching band musicians. One hundred students across a range of university popular music courses were surveyed using a 30-point questionnaire regarding their musical habits both within and external to their university courses. This was followed by noise dosimetry of studios/recording spaces and music venues popular with students. Questionnaire responses showed 76% of subjects reported having experienced symptoms associated with hearing loss, while only 18% reported using hearing protection devices. Rehearsals averaged 11.5 hrs/wk, with a mean duration 2 hrs 13 mins and mean level of 98 dB LAEQ. Ninety-four percent of subjects reported attending concerts or nightclubs at least once per week, and measured exposure in two of these venues ranged from 98 to 112 dB LAEQ with a mean of 98.9 dB LAEQ over a 4.5-hr period. Results suggested an extremely high hazard of excessive noise exposure among this group from both their social and study-based music activities.

  17. Nanomaterial toxicity testing in the 21st century: use of a predictive toxicological approach and high-throughput screening.

    PubMed

    Nel, Andre; Xia, Tian; Meng, Huan; Wang, Xiang; Lin, Sijie; Ji, Zhaoxia; Zhang, Haiyuan

    2013-03-19

    The production of engineered nanomaterials (ENMs) is a scientific breakthrough in material design and the development of new consumer products. While the successful implementation of nanotechnology is important for the growth of the global economy, we also need to consider the possible environmental health and safety (EHS) impact as a result of the novel physicochemical properties that could generate hazardous biological outcomes. In order to assess ENM hazard, reliable and reproducible screening approaches are needed to test the basic materials as well as nanoenabled products. A platform is required to investigate the potentially endless number of biophysicochemical interactions at the nano/bio interface, in response to which we have developed a predictive toxicological approach. We define a predictive toxicological approach as the use of mechanisms-based high-throughput screening in vitro to make predictions about the physicochemical properties of ENMs that may lead to the generation of pathology or disease outcomes in vivo. The in vivo results are used to validate and improve the in vitro high-throughput screening (HTS) and to establish structure-activity relationships (SARs) that allow hazard ranking and modeling by an appropriate combination of in vitro and in vivo testing. This notion is in agreement with the landmark 2007 report from the US National Academy of Sciences, "Toxicity Testing in the 21st Century: A Vision and a Strategy" (http://www.nap.edu/catalog.php?record_id=11970), which advocates increased efficiency of toxicity testing by transitioning from qualitative, descriptive animal testing to quantitative, mechanistic, and pathway-based toxicity testing in human cells or cell lines using high-throughput approaches. Accordingly, we have implemented HTS approaches to screen compositional and combinatorial ENM libraries to develop hazard ranking and structure-activity relationships that can be used for predicting in vivo injury outcomes. This

  18. List of Potentially Affected Sources for the Asphalt Processing and Roofing Manufacturing National Emission Standards for Hazardous Air Pollutants (NESHAP) November 2001

    EPA Pesticide Factsheets

    This is a November 2001 list of sources identified by EPA as potentially affected by the Asphalt Processing and Roofing Manufacturing National Emission Standards for Hazardous Air Pollutants (NESHAP).

  19. Operational Toxicology Research

    DTIC Science & Technology

    2006-08-01

    AFRL-HE-WP-TR-2006-0082 Operational Toxicology Research Darol E. Dodd MaryAnn Angell Alion Science and Technology Wright-Patterson AFB, OH 45433...CONTRACT NUMBER Operational Toxicology Research Contract F336l5-00-C-6060 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHORISI 5d. PROJECT NUMBER...AFRLlWS 06-1865 14. ABSTRACT This is a final report for the Operational Toxicology Research (OTR) Contract F33615-00-C-6060 initiated in March, 2001 to

  20. Environmental hazard assessment of a marine mine tailings deposit site and potential implications for deep-sea mining.

    PubMed

    Mestre, Nélia C; Rocha, Thiago L; Canals, Miquel; Cardoso, Cátia; Danovaro, Roberto; Dell'Anno, Antonio; Gambi, Cristina; Regoli, Francesco; Sanchez-Vidal, Anna; Bebianno, Maria João

    2017-09-01

    Portmán Bay is a heavily contaminated area resulting from decades of metal mine tailings disposal, and is considered a suitable shallow-water analogue to investigate the potential ecotoxicological impact of deep-sea mining. Resuspension plumes were artificially created by removing the top layer of the mine tailings deposit by bottom trawling. Mussels were deployed at three sites: i) off the mine tailings deposit area; ii) on the mine tailings deposit beyond the influence from the resuspension plumes; iii) under the influence of the artificially generated resuspension plumes. Surface sediment samples were collected at the same sites for metal analysis and ecotoxicity assessment. Metal concentrations and a battery of biomarkers (oxidative stress, metal exposure, biotransformation and oxidative damage) were measured in different mussel tissues. The environmental hazard posed by the resuspension plumes was investigated by a quantitative weight of evidence (WOE) model that integrated all the data. The resuspension of sediments loaded with metal mine tails demonstrated that chemical contaminants were released by trawling subsequently inducing ecotoxicological impact in mussels' health. Considering as sediment quality guidelines (SQGs) those indicated in Spanish action level B for the disposal of dredged material at sea, the WOE model indicates that the hazard is slight off the mine tailings deposit, moderate on the mine tailings deposit without the influence from the resuspension plumes, and major under the influence of the resuspension plumes. Portmán Bay mine tailings deposit is a by-product of sulphide mining, and despite differences in environmental setting, it can reflect the potential ecotoxic effects to marine fauna from the impact of resuspension of plumes created by deep-sea mining of polymetallic sulphides. A similar approach as in this study could be applied in other areas affected by sediment resuspension and for testing future deep-sea mining sites in

  1. Acute Toxicological Study of Ampicillin Anhydrate Microcapsules in Sprague-Dawley Rats.

    DTIC Science & Technology

    This document contains the results of an acute toxicological study to determine the toxicologic potential of ampicillin anhydrate microcapsules on...various organs of the rat. Keywords: Wound treatment; Antibiotic microcapsule ; Controlled release; Experimental data; Tables data. (aw)

  2. Approach to using mechanism-based structure activity relationship (SAR) analysis to assess human health hazard potential of nanomaterials.

    PubMed

    Lai, David Y

    2015-11-01

    With the increasing use and development of engineered nanoparticles in electronics, consumer products, pesticides, food and pharmaceutical industries, there is a growing concern about potential human health hazards of these materials. A number of studies have demonstrated that nanoparticle toxicity is extremely complex, and that the biological activity of nanoparticles will depend on a variety of physicochemical properties such as particle size, shape, agglomeration state, crystal structure, chemical composition, surface area and surface properties. Nanoparticle toxicity can be attributed to nonspecific interaction with biological structures due to their physical properties (e.g., size and shape) and biopersistence, or to specific interaction with biomolecules through their surface properties (e.g., surface chemistry and reactivity) or release of toxic ions. The toxic effects of most nanomaterials have not been adequately characterized and currently, there are many issues and challenges in toxicity testing and risk assessment of nanoparticles. Based on the possible mechanisms of action and available in vitro and in vivo toxicity database, this paper proposes an approach to using mechanism-based SAR analysis to assess the relative human health hazard/risk potential of various types of nanomaterials.

  3. Potential geologic hazards and constraints for blocks in proposed North Atlantic OCS Oil and gas lease sale 52

    USGS Publications Warehouse

    Carpenter, G.B.; Cardinell, A.P.; Francois, D.K.; Good, L.K.; Lewis, R.L.; Stiles, N.T.

    1982-01-01

    Analysis of high-resolution geophysical data collected over 540 blocks tentatively selected for leasing in proposed OCS Oil and Gas Lease Sale 52 (Georges Bank) revealed a number of potential geologic hazards to oil and gas exploration and development activities: evidence of mass movements and shallow gas deposits on the continental slope. No potential hazards were observed on the continental shelf or rise. Other geology-related problems, termed constraints because they pose a relatively low degree of risk and can be routinely dealt with by the use of existing technology have been observed on the continental shelf. Constraints identified in the proposed sale area are erosion, sand waves, filled channels and deep faults. Piston cores were collected for geotechnical analysis at selected locations on the continental slope in the proposed lease sale area. The core locations were selected to provide information on slope stability and to establish the general geotechnical properties of the sediments. Preliminary results of a testing program suggest that the surficial sediment cover is stable with respect to mass movement.

  4. Evaluation of potential surface rupture and review of current seismic hazards program at the Los Alamos National Laboratory. Final report

    SciTech Connect

    Not Available

    1991-12-09

    This report summarizes the authors review and evaluation of the existing seismic hazards program at Los Alamos National Laboratory (LANL). The report recommends that the original program be augmented with a probabilistic analysis of seismic hazards involving assignment of weighted probabilities of occurrence to all potential sources. This approach yields a more realistic evaluation of the likelihood of large earthquake occurrence particularly in regions where seismic sources may have recurrent intervals of several thousand years or more. The report reviews the locations and geomorphic expressions of identified fault lines along with the known displacements of these faults and last know occurrence of seismic activity. Faults are mapped and categorized into by their potential for actual movement. Based on geologic site characterization, recommendations are made for increased seismic monitoring; age-dating studies of faults and geomorphic features; increased use of remote sensing and aerial photography for surface mapping of faults; the development of a landslide susceptibility map; and to develop seismic design standards for all existing and proposed facilities at LANL.

  5. Toxicological Properties of the Organophosphorus Insecticide Dimethoate

    PubMed Central

    Sanderson, D. M.; Edson, E. F.

    1964-01-01

    The results are presented of extensive toxicological studies on the systemic organophosphate insecticide dimethoate, and compared with published results from other laboratories. It behaves as a typical indirect anticholinesterase, by conversion in the liver to at least four short-lived active metabolites, whose hydrolysis products are rapidly excreted, mainly in the urine. The acute oral toxicity of dimethoate is low in mammals but higher in avians. Dermal absorption is notably slow and dermal toxicity correspondingly low. Cumulative dosing of rats and guinea-pigs gave no cholinesterase inhibition at 0·7 and 4 mg./kg./day respectively. Dietary feeding to growing rats caused no cholinesterase inhibition at 0·5 mg./kg./day and no other effect at 10 times this dose. The main plant metabolite is identical with one formed in the liver, and comparative feeding tests with normal dimethoate and that partly metabolized in vegetation showed that residue analysis determined total hazard. Tests on humans, some with 32P-labelled material, confirmed that metabolism and urinary excretion are very rapid, that skin absorption is very slow, and that at least 2·5 mg., and probably up to 18 mg., could be ingested daily for at least three weeks without cholinesterase inhibition or other effects. Vapour hazards proved negligible. Oral toxicity was not potentiated by any of 17 other insecticides. The earliest detectable effect of dimethoate poisoning was always erythrocyte cholinesterase inhibition. Symptoms of poisoning could be effectively treated by atropine but not by oxime therapy. No known cases of occupational poisoning have occurred during five years' commercial usage of dimethoate. PMID:14106136

  6. Potential hazard of volatile organic compounds contained in household spray products

    NASA Astrophysics Data System (ADS)

    Rahman, Md Mahmudur; Kim, Ki-Hyun

    2014-03-01

    To assess the exposure levels of hazardous volatile pollutants released from common household spray products, a total of 10 spray products consisting of six body spray and four air spray products have been investigated. The body spray products included insect repellents (two different products), medicated patch, deodorant, hair spray, and humectant, whereas the air spray products included two different insecticides (mosquito and/or cockroach), antibacterial spray, and air freshener. The main objective of this study was to measure concentrations of 15 model volatile organic compounds (VOCs) using GC/MS coupled with a thermal desorber. In addition, up to 34 ‘compounds lacking authentic standards or surrogates (CLASS)' were also quantified based on the effective carbon number (ECN) theory. According to our analysis, the most common indoor pollutants like benzene, toluene, styrene, methyl ethyl ketone, and butyl acetate have been detected frequently in the majority of spray products with the concentration range of 5.3-125 mg L-1. If one assumes that the amount of spray products released into air reaches the 0.3 mL level for a given space size of 5 m3, the risk factor is expected to exceed the carcinogenic risk level set for benzene (10-5) by the U.S. EPA.

  7. Aftereffects of Subduction-Zone Earthquakes: Potential Tsunami Hazards along the Japan Sea Coast.

    PubMed

    Minoura, Koji; Sugawara, Daisuke; Yamanoi, Tohru; Yamada, Tsutomu

    2015-10-01

    The 2011 Tohoku-Oki Earthquake is a typical subduction-zone earthquake and is the 4th largest earthquake after the beginning of instrumental observation of earthquakes in the 19th century. In fact, the 2011 Tohoku-Oki Earthquake displaced the northeast Japan island arc horizontally and vertically. The displacement largely changed the tectonic situation of the arc from compressive to tensile. The 9th century in Japan was a period of natural hazards caused by frequent large-scale earthquakes. The aseismic tsunamis that inflicted damage on the Japan Sea coast in the 11th century were related to the occurrence of massive earthquakes that represented the final stage of a period of high seismic activity. Anti-compressive tectonics triggered by the subduction-zone earthquakes induced gravitational instability, which resulted in the generation of tsunamis caused by slope failing at the arc-back-arc boundary. The crustal displacement after the 2011 earthquake infers an increased risk of unexpected local tsunami flooding in the Japan Sea coastal areas.

  8. Toxicology Education Foundation

    MedlinePlus

    ... our newest video Toxicity Today offering a comic taste of the “sometimes not poisonous and sometimes very ... History In the Classroom Nanotechnology Occupational Toxicology Pesticides Product Safety Program Reproduction Risk Risk Assessment Smoking Tox ...

  9. Computational Toxicology (S)

    EPA Science Inventory

    The emerging field of computational toxicology applies mathematical and computer models and molecular biological and chemical approaches to explore both qualitative and quantitative relationships between sources of environmental pollutant exposure and adverse health outcomes. Th...

  10. Computational Toxicology (S)

    EPA Science Inventory

    The emerging field of computational toxicology applies mathematical and computer models and molecular biological and chemical approaches to explore both qualitative and quantitative relationships between sources of environmental pollutant exposure and adverse health outcomes. Th...

  11. National Toxicology Program

    MedlinePlus

    ... Initiative Public Health Public Health Impact Report on Carcinogens Evaluation of Alternative Toxicological Methods Health Assessment and ... 04/2016 HHS Releases the 14th Report on Carcinogens 11/03/2016 Board of Scientific Counselors Meeting ...

  12. Safety and Toxicology of Cannabinoids.

    PubMed

    Sachs, Jane; McGlade, Erin; Yurgelun-Todd, Deborah

    2015-10-01

    There is extensive research on the safety, toxicology, potency, and therapeutic potential of cannabis. However, uncertainty remains facilitating continued debate on medical and recreational cannabis policies at the state and federal levels. This review will include a brief description of cannabinoids and the endocannabinoid system; a summary of the acute and long-term effects of cannabis; and a discussion of the therapeutic potential of cannabis. The conclusions about safety and efficacy will then be compared with the current social and political climate to suggest future policy directions and general guidelines.

  13. IRIS TOXICOLOGICAL REVIEW AND SUMMARY ...

    EPA Pesticide Factsheets

    EPA's assessment of the noncancer health effects and carcinogenic potential of Beryllium was added to the IRIS database in 1998. The IRIS program is updating the IRIS assessment for Beryllium. This update will incorporate health effects information published since the last assessment was prepared as well as new risk assessment methods. The IRIS assessment for Beryllium will consist of an updated Toxicological Review and IRIS Summary. The Toxicological Review is a critical review of the physicochemical and toxicokinetic properties of the chemical and its toxicity in humans and experimental systems. The assessment will present reference values for noncancer effects of Beryllium (RfD and RfC) and a cancer assessment. The Toxicological Review and IRIS Summary will be subject to internal peer consultation, Agency and Interagency review, and external scientific peer review. The final products will constitute the Agency's opinion on the toxicity of Beryllium. Beryllium is a light alkaline earth metal used in metal alloys and in high-performance products in the metallurgical, aerospace, and nuclear industries. According to the Superfund database, beryllium is found in over 300 NPL sites

  14. Leveraging a large scale mammalian pharmacological dataset to prioritize potential environmental hazard of pharmaceuticals

    EPA Science Inventory

    The potential for pharmaceuticals in the environment to cause adverse ecological effects is of increasing concern. Given the thousands of active pharmaceutical ingredients (APIs) which can enter the aquatic environment through various means, a current challenge in aquatic toxicol...

  15. 76 FR 5370 - Potential Addition of Vapor Intrusion Component to the Hazard Ranking System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ... facility, the potential for contamination of drinking water supplies, direct human contact, destruction of sensitive ecosystems, and other appropriate factors. Section 105(a)(8)(B) of CERCLA requires that the...

  16. Prioritization of pharmaceuticals for potential environmental hazard through leveraging a large scale mammalian pharmacological dataset

    EPA Science Inventory

    To proceed in the investigation of potential effects of thousands of active pharmaceutical ingredients (API) which may enter the aquatic environment, a cohesive research strategy, specifically a prioritization is paramount. API are biologically active, with specific physiologica...

  17. Prioritization of pharmaceuticals for potential environmental hazard through leveraging a large scale mammalian pharmacological dataset

    EPA Science Inventory

    To proceed in the investigation of potential effects of thousands of active pharmaceutical ingredients (API) which may enter the aquatic environment, a cohesive research strategy, specifically a prioritization is paramount. API are biologically active, with specific physiologica...

  18. Leveraging a large scale mammalian pharmacological dataset to prioritize potential environmental hazard of pharmaceuticals

    EPA Science Inventory

    The potential for pharmaceuticals in the environment to cause adverse ecological effects is of increasing concern. Given the thousands of active pharmaceutical ingredients (APIs) which can enter the aquatic environment through various means, a current challenge in aquatic toxicol...

  19. The significance of SAR remote sensing in volcano-geology for hazard and resource potential mapping

    NASA Astrophysics Data System (ADS)

    Saepuloh, Asep; Bakker, Erwin; Suminar, Wulan

    2017-07-01

    Geological mapping at volcanic terrain is crucial for providing accurate information related to the distribution of volcanic products and volcano-related structures. The volcano-geology map is basis information, not only for hazard mitigation related to volcanic activity, but also for resource exploration as well as scientific purposes. Therefore, the accurate detection and observation of volcanic products and their genetics are necessary for volcano-geology mapping. The classical problem at Torrid Zone such as cloud, dense vegetation, heavy weathering, and erosion usually hamper the detection and observation of volcanic products and their structures. Moreover, the stratigraphic of volcanic products generally follows paleo-topography which was buried by the products. Overcoming the problem, we exploited the applicability of remotely sensed data to provide the great assistance for field based observations at volcanic field in Indonesia. The Geomorphologic and Structural Features (GSF) of the Synthetic Aperture Radar (SAR) are the selected parameters to define the distribution of the volcanic products. We explained about the significant of SAR identification to detect and interpret volcano-geology parameters such as eruption centers, volcanic products, depositional mechanisms, and volcanic structures especially at complex of volcanoes. The fall and flowing mechanisms controlled the depositional process were also analyzed to obtain the genetic of volcanic products. For young volcanoes, the quantitative techniques based on SAR surface roughness and polarized signatures are effective to identify volcanic formations and their sources. However, for old volcanoes the visual analyses of GSF is superior to identify the volcanic units and structures. We selected two volcanic complexes at Mts. Guntur and Malabar in West Java (Indonesia) presenting the young and old volcanic field characteristics under Torrid Zone condition.

  20. Advancing Risk Assessment through the Application of Systems Toxicology

    PubMed Central

    Sauer, John Michael; Kleensang, André; Peitsch, Manuel C.; Hayes, A. Wallace

    2016-01-01

    Risk assessment is the process of quantifying the probability of a harmful effect to individuals or populations from human activities. Mechanistic approaches to risk assessment have been generally referred to as systems toxicology. Systems toxicology makes use of advanced analytical and computational tools to integrate classical toxicology and quantitative analysis of large networks of molecular and functional changes occurring across multiple levels of biological organization. Three presentations including two case studies involving both in vitro and in vivo approaches described the current state of systems toxicology and the potential for its future application in chemical risk assessment. PMID:26977253