Engineering organs.

PubMed

Atala, Anthony

2009-10-01

Applications of regenerative medicine technology may offer novel therapies for patients with injuries, end-stage organ failure, or other clinical problems. Currently, patients suffering from diseased and injured organs can be treated with transplanted organs. However, there is a severe shortage of donor organs that is worsening yearly as the population ages and new cases of organ failure increase. Scientists in the field of regenerative medicine and tissue engineering are now applying the principles of cell transplantation, material science, and bioengineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. The stem cell field is also advancing rapidly, opening new avenues for this type of therapy. For example, therapeutic cloning and cellular reprogramming may one day provide a potentially limitless source of cells for tissue engineering applications. Although stem cells are still in the research phase, some therapies arising from tissue engineering endeavors have already entered the clinical setting successfully, indicating the promise regenerative medicine holds for the future.

Limitless as a neuro-pharmaceutical experiment and as a Daseinsanalyse: on the use of fiction in preparatory debates on cognitive enhancement.

PubMed

Zwart, Hub

2014-02-01

Limitless is a movie (released in 2011) as well as a novel (published in 2001) about a tormented author who (plagued by a writer's block) becomes an early user of an experimental designer drug. The wonder drug makes him highly productive overnight and even allows him to make a fortune on the stock market. At the height of his career, however, the detrimental side-effects become increasingly noticeable. In this article, Limitless is analysed from two perspectives. First of all, building on the views of the French novelist Emile Zola, the novel is seen as the report of a closely monitored experiment. Subsequently, building on the phenomenology of Ludwig Binswanger, I will show how the cognitive enhancement drug not only boosts the protagonist's information processing capacities, but also modifies his experience of space and time, his sense of spatiality, his way of being-in-the-world. On the basis of these (complementary) analyses I will indicate how genres of the imagination (such as movies and novels) may play a significant role in assessing the societal implications of emerging technological developments such as neuro-enhancement, especially during the preparatory or anticipatory stage.

Engineered heart tissues and induced pluripotent stem cells: Macro- and microstructures for disease modeling, drug screening, and translational studies.

PubMed

Tzatzalos, Evangeline; Abilez, Oscar J; Shukla, Praveen; Wu, Joseph C

2016-01-15

Engineered heart tissue has emerged as a personalized platform for drug screening. With the advent of induced pluripotent stem cell (iPSC) technology, patient-specific stem cells can be developed and expanded into an indefinite source of cells. Subsequent developments in cardiovascular biology have led to efficient differentiation of cardiomyocytes, the force-producing cells of the heart. iPSC-derived cardiomyocytes (iPSC-CMs) have provided potentially limitless quantities of well-characterized, healthy, and disease-specific CMs, which in turn has enabled and driven the generation and scale-up of human physiological and disease-relevant engineered heart tissues. The combined technologies of engineered heart tissue and iPSC-CMs are being used to study diseases and to test drugs, and in the process, have advanced the field of cardiovascular tissue engineering into the field of precision medicine. In this review, we will discuss current developments in engineered heart tissue, including iPSC-CMs as a novel cell source. We examine new research directions that have improved the function of engineered heart tissue by using mechanical or electrical conditioning or the incorporation of non-cardiomyocyte stromal cells. Finally, we discuss how engineered heart tissue can evolve into a powerful tool for therapeutic drug testing. Copyright © 2015 Elsevier B.V. All rights reserved.

The hospital tech laboratory: quality innovation in a new era of value-conscious care.

PubMed

Keteyian, Courtland K; Nallamothu, Brahmajee K; Ryan, Andrew M

2017-08-01

For decades, the healthcare industry has been incentivized to develop new diagnostic technologies, but this limitless progress fueled rapidly growing expenditures. With an emphasis on value, the future will favor information synthesis and processing over pure data generation, and hospitals will play a critical role in developing these systems. A Michigan Medicine, IBM, and AirStrip partnership created a robust streaming analytics platform tasked with creating predictive algorithms for critical care with the potential to support clinical decisions and deliver significant value.

The Army’s Activities in Artificial Intelligence/Robotics,

DTIC Science & Technology

1982-08-27

r7 AD-,30 128 THE ARMY S ACT"IVITES AN ARTIFICIAL INTELLGENCE/ROBOT CS U) ARMY ENGINEER TOPOGRAPHIC LASS FORT RELVOIR VA R D LEIGHT 27 AUG 82 ETL-042...necessary for autonomous battlefield systems in the 1990’ s . The potential applications of AI/R systems to Army needs (’ appear to be limitless. DARCOM and...procurement. The contract statement or work had four tasks to be performed. They were: a. From Army concepts and doctrine for the 1990’ s and beyond, such as

RRx-001: a systemically non-toxic M2-to-M1 macrophage stimulating and prosensitizing agent in Phase II clinical trials.

PubMed

Oronsky, Bryan; Paulmurugan, Ramasamy; Foygel, Kira; Scicinski, Jan; Knox, Susan J; Peehl, Donna; Zhao, Hongjuan; Ning, Shoucheng; Cabrales, Pedro; Summers, Thomas A; Reid, Tony R; Fitch, William L; Kim, Michelle M; Trepel, Jane B; Lee, Min-Jung; Kesari, Santosh; Abrouk, Nacer D; Day, Regina M; Oronsky, Arnold; Ray, Carolyn M; Carter, Corey A

2017-01-01

According to Hanahan and Weinberg, cancer manifests as six essential physiologic hallmarks: (1) self-sufficiency in growth signals, (2) insensitivity to growth-inhibitory signals, (3) evasion of programmed cell death, (4) limitless replicative potential, (5) sustained angiogenesis, and (6) invasion and metastasis. As a facilitator of these traits as well as immunosuppression and chemoresistance, the presence of tumor-associated macrophages (TAMs) may serve as the seventh hallmark of cancer. Anticancer agents that successfully reprogram TAMs to target rather than support tumor cells may hold the key to better therapeutic outcomes. Areas covered: This article summarizes the characteristics of the macrophage-stimulating agent RRx-001, a molecular iconoclast, sourced from the aerospace industry, with a particular emphasis on the cell-to-cell transfer mechanism of action (RBCs to TAMs) underlying its antitumor activity as well as its chemo and radioprotective properties, consolidated from various preclinical and clinical studies. Expert opinion: RRx-001 is macrophage-stimulating agent with the potential to synergize with chemotherapy, radiotherapy and immunotherapy while simultaneously protecting normal tissues from their cytotoxic effects. Given the promising indications of activity in multiple tumor types and these normal tissue protective properties, RRx-001 may be used to treat a broad spectrum of malignancies, if it is approved in the future.

A review on energy harvesting approaches for renewable energies from ambient vibrations and acoustic waves using piezoelectricity

NASA Astrophysics Data System (ADS)

Ahmed, Riaz; Mir, Fariha; Banerjee, Sourav

2017-08-01

The principal objective of this article is to categorically review and compare the state of the art vibration based energy harvesting approaches. To evaluate the contemporary methodologies with respect to their physics, average power output and operational frequencies, systematically divided and easy readable tables are presented followed by the description of the energy harvesting methods. Energy harvesting is the process of obtaining electrical energy from the surrounding vibratory mechanical systems through an energy conversion method using smart structures, like, piezoelectric, electrostatic materials. Recent advancements in low power electronic gadgets, micro electro mechanical systems, and wireless sensors have significantly increased local power demand. In order to circumvent the energy demand; to allow limitless power supply, and to avoid chemical waste from conventional batteries, low power local energy harvesters are proposed for harvesting energy from different ambient energy sources. Piezoelectric materials have received tremendous interest in energy harvesting technology due to its unique ability to capitalize the ambient vibrations to generate electric potential. Their crystalline configuration allows the material to convert mechanical strain energy into electrical potential, and vice versa. This article discusses the various approaches in vibration based energy scavenging where piezoelectric materials are employed as the energy conversion medium.

Molecular pharming - VLPs made in plants.

PubMed

Marsian, Johanna; Lomonossoff, George P

2016-02-01

Plant-based expression offers a safe, inexpensive and potentially limitless way to produce therapeutics in a quick and flexible manner. Plants require only simple inorganic nutrients, water, carbon dioxide and sunlight for efficient growth. Virus-like particles (VLPs) are convincing look-alikes of viruses but without carrying infectious genomic material. However, they can still elicit a very potent immune response which makes them ideal vaccine candidates. In this review the different methods of plant expression are described together with the most recent developments in the field of transiently-expressed plant-made VLPs. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

The Ethics and Reality of Rationing in Medicine

PubMed Central

Scheunemann, Leslie P.

2011-01-01

Rationing is the allocation of scarce resources, which in health care necessarily entails withholding potentially beneficial treatments from some individuals. Rationing is unavoidable because need is limitless and resources are not. How rationing occurs is important because it not only affects individual lives but also expresses society’s most important values. This article discusses the following topics: (1) the inevitability of rationing of social goods, including medical care; (2) types of rationing; (3) ethical principles and procedures for fair allocation; and (4) whether rationing ICU care to those near the end of life would result in substantial cost savings. PMID:22147821

Functionalized gold nanoparticles for the binding, stabilization, and delivery of therapeutic DNA, RNA, and other biological macromolecules

PubMed Central

DeLong, Robert K; Reynolds, Christopher M; Malcolm, Yaneika; Schaeffer, Ashley; Severs, Tiffany; Wanekaya, Adam

2010-01-01

Nanotechnology has virtually exploded in the last few years with seemingly limitless opportunity across all segments of our society. If gene and RNA therapy are to ever realize their full potential, there is a great need for nanomaterials that can bind, stabilize, and deliver these macromolecular nucleic acids into human cells and tissues. Many researchers have turned to gold nanomaterials, as gold is thought to be relatively well tolerated in humans and provides an inert material upon which nucleic acids can attach. Here, we review the various strategies for associating macromolecular nucleic acids to the surface of gold nanoparticles (GNPs), the characterization chemistries involved, and the potential advantages of GNPs in terms of stabilization and delivery. PMID:24198471

2015 Materials Research Society Spring Meeting

DTIC Science & Technology

2016-05-12

State University, Raleigh, NC 27695  Eicke R. Weber, Fraunhofer Institute for  Solar  Energy Systems, Freiburg, Germany    Symposium Highlights:  The...emission from fossil fuels.  Materials hold the key to  advanced renewable energy technologies including  solar  cells, batteries, fuel cells, and catalysis...systems. For example, among renewable energy technologies,  solar  energy is  a limitless source of energy, and photovoltaic energy conversion is one of the

Cell Sage Re Mix HD

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gering, Kevin

Cell Sage is a computational tool that allows science-based evaluation and exploration of battery life cycles over near limitless combination of aging conditions which helps battery end-users to optimize their investments.

Social media and social work education: understanding and dealing with the new digital world.

PubMed

Fang, Lin; Mishna, Faye; Zhang, Vivian F; Van Wert, Melissa; Bogo, Marion

2014-10-01

Accompanying the multiple benefits and innovations of social media are the complex ethical and pedagogical issues that challenge social work educators. Without a clear understanding of the blurred boundaries between public and private, the potentially limitless and unintended audiences, as well as the permanency of the information shared online, social work students who use social media can find themselves in difficult situations in their personal and professional lives. In this article, we present three scenarios that illustrate issues and complexities involving social media use by social work students, followed by a discussion and recommendations for social work educators.

Stem cell technology for drug discovery and development.

PubMed

Hook, Lilian A

2012-04-01

Stem cells have enormous potential to revolutionise the drug discovery process at all stages, from target identification through to toxicology studies. Their ability to generate physiologically relevant cells in limitless supply makes them an attractive alternative to currently used recombinant cell lines or primary cells. However, realisation of the full potential of stem cells is currently hampered by the difficulty in routinely directing stem cell differentiation to reproducibly and cost effectively generate pure populations of specific cell types. In this article we discuss how stem cells have already been used in the drug discovery process and how novel technologies, particularly in relation to stem cell differentiation, can be applied to attain widespread adoption of stem cell technology by the pharmaceutical industry. Copyright © 2011 Elsevier Ltd. All rights reserved.

76 FR 69311 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-08

...'') and broker-dealers increased authority and flexibility to offer new and unique market data to..., providing virtually limitless opportunities for entrepreneurs who wish to produce and distribute their own...

Human-machine interface hardware: The next decade

NASA Technical Reports Server (NTRS)

Marcus, Elizabeth A.

1991-01-01

In order to understand where human-machine interface hardware is headed, it is important to understand where we are today, how we got there, and what our goals for the future are. As computers become more capable, faster, and programs become more sophisticated, it becomes apparent that the interface hardware is the key to an exciting future in computing. How can a user interact and control a seemingly limitless array of parameters effectively? Today, the answer is most often a limitless array of controls. The link between these controls and human sensory motor capabilities does not utilize existing human capabilities to their full extent. Interface hardware for teleoperation and virtual environments is now facing a crossroad in design. Therefore, we as developers need to explore how the combination of interface hardware, human capabilities, and user experience can be blended to get the best performance today and in the future.

Application of Percolation Theory to Complex Interconnected Networks in Advanced Functional Composites

NASA Astrophysics Data System (ADS)

Hing, P.

2011-11-01

Percolation theory deals with the behaviour of connected clusters in a system. Originally developed for studying the flow of liquid in a porous body, the percolation theory has been extended to quantum computation and communication, entanglement percolation in quantum networks, cosmology, chaotic situations, properties of disordered solids, pandemics, petroleum industry, finance, control of traffic and so on. In this paper, the application of various models of the percolation theory to predict and explain the properties of a specially developed family of dense sintered and highly refractory Al2O3-W composites for potential application in high intensity discharge light sources such as high pressure sodium lamps and ceramic metal halide lamps are presented and discussed. The low cost, core-shell concept can be extended to develop functional composite materials with unusual dielectric, electrical, magnetic, superconducting, and piezoelectric properties starting from a classical insulator. The core shell concept can also be applied to develop catalysts with high specific surface areas with minimal amount of expensive platinium, palladium or rare earth nano structured materials for light harvesting, replicating natural photosynthesis, in synthetic zeolite composites for the cracking and separation of crude oil. There is also possibility of developing micron and nanosize Faraday cages for quantum devices, nano electronics and spintronics. The possibilities are limitless.

It's Academic

ERIC Educational Resources Information Center

Fernandez, Kim

2012-01-01

Colleges, universities, and independent schools use branding to attract students, keep alumni close, and unite faculty behind the institution. That last bit is key because one can't box and ship global perspectives, personal attention, flexible programs, campus traditions, innovative research, and the limitless other qualities that make…

Limitless Horizons: Careers in Aerospace.

ERIC Educational Resources Information Center

Lewis, Mary H.

This is a manual for acquainting students with pertinent information relating to career choices in aerospace science, engineering, and technology. The first chapter presents information about the aerospace industry by describing disciplines typical of this industry. The National Aeronautics and Space Administration's (NASA) classification system…

Disturbance regimes and ecological responses across sites

USDA-ARS?s Scientific Manuscript database

Disturbances affect ecosystems in almost limitless ways. The effects of disturbances extend beyond the initial impacts that are usually visible to the human eye. Therefore, for many disturbances long-term data are needed to unravel their effects. This chapter first presents characteristics of distu...

Why Subsidize Our Enemies?

ERIC Educational Resources Information Center

Malott, Robert H.

1979-01-01

The business community must manage its philanthropy with the same deliberateness and pragmatism it generally conducts in business activities. Issues covered are: financing of people who undermine the free enterprise system, academic freedom, collectivist society under limitless government, discernment in giving, and guidelines to ensure that…

Recovery Online

ERIC Educational Resources Information Center

Clark, John R.

2007-01-01

Since the founding of Alcoholics Anonymous (AA) in 1935, programs offering opportunity for recovery from alcoholism and other addictions have undergone vast changes. The Internet has created nearly limitless opportunities for recovering people and those seeking recovery to find both meetings and places where they can gather virtually and discuss…

Measurement-Driven Characterization of the Mobile Environment

ERIC Educational Resources Information Center

Soroush, Hamed

2013-01-01

The concurrent deployment of high-quality wireless networks and large-scale cloud services offers the promise of secure ubiquitous access to seemingly limitless amount of content. However, as users' expectations have grown more demanding, the performance and connectivity failures endemic to the existing networking infrastructure have become more…

Lead (Pb) Hohlraum: Target for Inertial Fusion Energy

PubMed Central

Ross, J. S.; Amendt, P.; Atherton, L. J.; Dunne, M.; Glenzer, S. H.; Lindl, J. D.; Meeker, D.; Moses, E. I.; Nikroo, A.; Wallace, R.

2013-01-01

Recent progress towards demonstrating inertial confinement fusion (ICF) ignition at the National Ignition Facility (NIF) has sparked wide interest in Laser Inertial Fusion Energy (LIFE) for carbon-free large-scale power generation. A LIFE-based fleet of power plants promises clean energy generation with no greenhouse gas emissions and a virtually limitless, widely available thermonuclear fuel source. For the LIFE concept to be viable, target costs must be minimized while the target material efficiency or x-ray albedo is optimized. Current ICF targets on the NIF utilize a gold or depleted uranium cylindrical radiation cavity (hohlraum) with a plastic capsule at the center that contains the deuterium and tritium fuel. Here we show a direct comparison of gold and lead hohlraums in efficiently ablating deuterium-filled plastic capsules with soft x rays. We report on lead hohlraum performance that is indistinguishable from gold, yet costing only a small fraction. PMID:23486285

Lead (Pb) hohlraum: target for inertial fusion energy.

PubMed

Ross, J S; Amendt, P; Atherton, L J; Dunne, M; Glenzer, S H; Lindl, J D; Meeker, D; Moses, E I; Nikroo, A; Wallace, R

2013-01-01

Recent progress towards demonstrating inertial confinement fusion (ICF) ignition at the National Ignition Facility (NIF) has sparked wide interest in Laser Inertial Fusion Energy (LIFE) for carbon-free large-scale power generation. A LIFE-based fleet of power plants promises clean energy generation with no greenhouse gas emissions and a virtually limitless, widely available thermonuclear fuel source. For the LIFE concept to be viable, target costs must be minimized while the target material efficiency or x-ray albedo is optimized. Current ICF targets on the NIF utilize a gold or depleted uranium cylindrical radiation cavity (hohlraum) with a plastic capsule at the center that contains the deuterium and tritium fuel. Here we show a direct comparison of gold and lead hohlraums in efficiently ablating deuterium-filled plastic capsules with soft x rays. We report on lead hohlraum performance that is indistinguishable from gold, yet costing only a small fraction.

Competitive intelligence in the photonics industry: unlocking the box

NASA Astrophysics Data System (ADS)

James, Dick

2002-05-01

The photonics industry at present seems to be characterised by depressive chaos. Particularly in the telecommunications sector, what was perceived as a paradise of limitless growth has turned into a desert where shambling relics of formerly great companies stagger towards an unknown horizon, hoping for some signs of growth.

Role Playing in Physical Education to Teach in the Affective Domain

ERIC Educational Resources Information Center

Samalot-Rivera, Amaury

2014-01-01

Using role playing during physical education provides limitless opportunities for intervention and for the demonstration of personal and social qualities. The purpose of this article is to provide easy steps for implementing role playing as a strategy to teach social skills to students in the physical education setting.

"A Virtually Limitless Resource"

ERIC Educational Resources Information Center

Stanistreet, Paul

2008-01-01

With skills such as flexibility and originality increasingly required by an economy struggling to adapt to sudden and seismic change, there is renewed interest in what engagement in culture and creativity can offer. This author discovered that the difference such engagement can make to people's lives has long been recognised at Morley College.…

Earth-Base: A Free And Open Source, RESTful Earth Sciences Platform

NASA Astrophysics Data System (ADS)

Kishor, P.; Heim, N. A.; Peters, S. E.; McClennen, M.

2012-12-01

This presentation describes the motivation, concept, and architecture behind Earth-Base, a web-based, RESTful data-management, analysis and visualization platform for earth sciences data. Traditionally web applications have been built directly accessing data from a database using a scripting language. While such applications are great at bring results to a wide audience, they are limited in scope to the imagination and capabilities of the application developer. Earth-Base decouples the data store from the web application by introducing an intermediate "data application" tier. The data application's job is to query the data store using self-documented, RESTful URIs, and send the results back formatted as JavaScript Object Notation (JSON). Decoupling the data store from the application allows virtually limitless flexibility in developing applications, both web-based for human consumption or programmatic for machine consumption. It also allows outside developers to use the data in their own applications, potentially creating applications that the original data creator and app developer may not have even thought of. Standardized specifications for URI-based querying and JSON-formatted results make querying and developing applications easy. URI-based querying also allows utilizing distributed datasets easily. Companion mechanisms for querying data snapshots aka time-travel, usage tracking and license management, and verification of semantic equivalence of data are also described. The latter promotes the "What You Expect Is What You Get" (WYEIWYG) principle that can aid in data citation and verification.

Information in the Biosphere: Biological and Digital Worlds.

PubMed

Gillings, Michael R; Hilbert, Martin; Kemp, Darrell J

2016-03-01

Evolution has transformed life through key innovations in information storage and replication, including RNA, DNA, multicellularity, and culture and language. We argue that the carbon-based biosphere has generated a cognitive system (humans) capable of creating technology that will result in a comparable evolutionary transition. Digital information has reached a similar magnitude to information in the biosphere. It increases exponentially, exhibits high-fidelity replication, evolves through differential fitness, is expressed through artificial intelligence (AI), and has facility for virtually limitless recombination. Like previous evolutionary transitions, the potential symbiosis between biological and digital information will reach a critical point where these codes could compete via natural selection. Alternatively, this fusion could create a higher-level superorganism employing a low-conflict division of labor in performing informational tasks. Copyright © 2015 Elsevier Ltd. All rights reserved.

Using Hybrid Modeling to Develop Innovative Activities

ERIC Educational Resources Information Center

Lichtman, Brenda; Avans, Diana

2005-01-01

This article describes a hybrid activities model that physical educators can use with students in grades four and above to create virtually a limitless array of novel games. A brief introduction to the basic theory is followed by descriptions of some hybrid games. Hybrid games are typically the result of merging two traditional sports or other…

Serendipity in Physics Research

ERIC Educational Resources Information Center

Khoon, Koh Aik

2008-01-01

This paper relates several serendipitous discoveries in physics in the 19th and 20th centuries. They are all experimental in nature and the places range from reputable universities to modern research laboratories. The discoverers could be working in solo or in group. The subject discovered ranges from the finest nucleus to the limitless cosmos.…

Limitless Learning: Assessing Social Media Use for Global Workplace Learning

ERIC Educational Resources Information Center

Breunig, Karl Joachim

2016-01-01

Purpose: This empirical paper aims to assess how social media can foster workplace learning within a globally dispersed project environment. In general, there are few studies on the use of social media in organizations, and many of these emphasize on issues related to knowledge transfer. Although learning traditionally has been as acquisition of…

Holy Gargoyles! Art Curriculum That Works

ERIC Educational Resources Information Center

Healy, John W.

2005-01-01

The subject of gargoyles is engaging for children. Creating their own gargoyles is a journey to a place of fantasy and imagination. Ghosts, goblins, creatures of the night--this is the stuff for which students have a limitless reserve of energy. What more appropriate time than Halloween to share with them the history of these functional--and…

Limits to Inclusion

ERIC Educational Resources Information Center

Hansen, Janne Hedegaard

2012-01-01

In this article, I will argue that a theoretical identification of the limit to inclusion is needed in the conceptual identification of inclusion. On the one hand, inclusion is formulated as a vision that is, in principle, limitless. On the other hand, there seems to be an agreement that inclusion has a limit in the pedagogical practice. However,…

Creating Digital Narratives: Guideline for Early Childhood Educators

ERIC Educational Resources Information Center

Fenty, Nicole S.; Anderson, Elizabeth

2016-01-01

As the internet and internet-enabled devices have become more accessible, people around the world now have life-changing information at their fingertips, available at a speed and ease unfathomable just a generation ago. While the information age certainly has its pitfalls, the possibilities for economic and social progress are seemingly limitless.…

Hydrological tracers using nanobiotechnology: proof of concept.

PubMed

Sharma, Asha N; Luo, Dan; Walter, M Todd

2012-08-21

In order to answer questions that involve differentiating among multiple and potentially interacting hydrological flowpaths, it would be ideal to use multiple tracers with identical transport properties that can nonetheless be distinguished from each other. This paper describes the development and proof of concept of a new kind of engineered tracer system that allows a large number of individual tracers to be simultaneously distinguished from one another. This new tracer is composed of polylactic acid (PLA) microspheres into which short strands of synthetic DNA and paramagnetic iron oxide nanoparticles are incorporated. The synthetic DNA serves as the "label" or "tag" in our tracers that allow us to distinguish one tracer from another, and paramagnetic iron oxide nanoparticles are included in the tracer to facilitate magnetic concentration of the tracers in potentially dilute water samples. Some potential advantages of this tracer concept include: virtually limitless uniquely labeled tracers, highly sensitive detection, and relatively moderate expense. Three proof-of-concept experiments at scales ranging from orders of 10 cm to 100 m demonstrated the use of the tracer system.

"In Landlessness Alone Resides the Highest Truth"; Or, at Sea with Honors

ERIC Educational Resources Information Center

Dingledine, Don

2013-01-01

As an English professor specializing in American literature and possessing a passion for one nineteenth-century American novel in particular, Don Dingledine writes that one reason he loves to teach "Moby-Dick" is the seemingly limitless ways in which it speaks to human actions and events in our own time. Melville's timeless novel has…

Anticipating the Exception, Not the Rule: Forming Policy for Student Use of Technology in the Classroom

ERIC Educational Resources Information Center

Becker, Daniel

2013-01-01

Students across institutions of higher learning come equipped with pocket-sized devices that allow them to record images, audio, and video from their classrooms, and instantaneously edit and share recorded content with a limitless audience. Prior to commencing instruction, postsecondary instructors are advised to learn the policy of their…

Participatory Technologies as Workplace Learning Tools: Employees' Perceptions and Use

ERIC Educational Resources Information Center

Francone, Mary Marada

2010-01-01

Corporate Learning and Development must align learning goals with the needs of the business it serves. In times of rapid change and limitless information, it becomes unreasonable to expect a Learning and Development group to design for and deliver all the learning its workforce needs. In response, corporate learning leaders are exploring if and…

Coded aperture imaging with uniformly redundant arrays

DOEpatents

Fenimore, Edward E.; Cannon, Thomas M.

1980-01-01

A system utilizing uniformly redundant arrays to image non-focusable radiation. The uniformly redundant array is used in conjunction with a balanced correlation technique to provide a system with no artifacts such that virtually limitless signal-to-noise ratio is obtained with high transmission characteristics. Additionally, the array is mosaicked to reduce required detector size over conventional array detectors.

Coded aperture imaging with uniformly redundant arrays

DOEpatents

Fenimore, Edward E.; Cannon, Thomas M.

1982-01-01

A system utilizing uniformly redundant arrays to image non-focusable radiation. The uniformly redundant array is used in conjunction with a balanced correlation technique to provide a system with no artifacts such that virtually limitless signal-to-noise ratio is obtained with high transmission characteristics. Additionally, the array is mosaicked to reduce required detector size over conventional array detectors.

Approaches to Learning Design: Past the Head and the Hands to the HEART of the Matter

ERIC Educational Resources Information Center

Donald, Claire; Blake, Adam; Girault, Isabelle; Datt, Ashwini; Ramsay, Elizabeth

2009-01-01

Digital technologies have been used increasingly in open, distance, and flexible learning to both facilitate learning and depict learning designs. While the portable nature of a learning design once captured in digital form appears to offer limitless possibilities for sharing and reuse, dissemination initiatives have failed to thrive. This may be…

Learning By Serving: 2,000 Ideas for Service-Learning Projects. Hot Topics: Usable Research.

ERIC Educational Resources Information Center

Follman, Joseph; And Others

Defining service learning as the formal integration of public service into student instruction and learning, this guide provides teachers with ideas for narrowing the gap between what students do in school and what they will do after they leave school. The example activities, derived from actual projects, demonstrate the nearly limitless range of…

Human stem cells and drug screening: opportunities and challenges.

PubMed

Ebert, Allison D; Svendsen, Clive N

2010-05-01

High-throughput screening technologies are widely used in the early stages of drug discovery to rapidly evaluate the properties of thousands of compounds. However, they generally rely on testing compound libraries on highly proliferative immortalized or cancerous cell lines, which do not necessarily provide an accurate indication of the effects of compounds in normal human cells or the specific cell type under study. Recent advances in stem cell technology have the potential to allow production of a virtually limitless supply of normal human cells that can be differentiated into any specific cell type. Moreover, using induced pluripotent stem cell technology, they can also be generated from patients with specific disease traits, enabling more relevant modelling and drug screens. This article discusses the opportunities and challenges for the use of stem cells in drug screening with a focus on induced pluripotent stem cells.

Generation of Corneal Keratocytes from Human Embryonic Stem Cells.

PubMed

Hertsenberg, Andrew J; Funderburgh, James L

2016-01-01

Human Embryonic Stem Cells (hESC) offer an important resource as a limitless supply of any differentiated cell type of the human body. Keratocytes, cells from the corneal stroma, may have the potential for restoration of vision in cell therapy and biomedical engineering applications, but these specialized cells are not readily expanded in vitro. Here we describe a two-part method to produce keratocytes from the H1 hESC cell line. The hESC cells, maintained and expanded in feeder-free culture medium are first differentiated to neural crest cells using the stromal-derived inducing activity (SDIA) of the PA6 mouse embryonic fibroblast cell line. The resulting neural crest cells are selected by their expression of cell-surface CD271 and subsequently cultured as 3D pellets in a defined differentiation medium to induce a keratocyte phenotype.

Elements, Compounds & Mixtures. Physical Science in Action[TM]. Schlessinger Science Library. [Videotape].

ERIC Educational Resources Information Center

2000

The world contains a limited number of elements--the purest form of matter. But when these elements are combined, the possibilities are limitless! Water, carbon dioxide and salt are just a few examples of how elements can be combined to form entirely new substances. Many of these combinations occur naturally, while others are man-made. Students…

Some effects of external stores on the static stability of fighter airplanes

NASA Technical Reports Server (NTRS)

Spearman, M. L.

1972-01-01

Fighter airplanes may have a seemingly limitless number of external store arrangements. Some practical considerations and some aerodynamic considerations must be taken into account in the arrangements of the external stores. The nature of the problems concerning the type of store arrangement involved and the type of airplane on which the stores are installed are reported.

For Man and Country: Atheist Chaplains in the U.S. Army

DTIC Science & Technology

2014-06-13

cardinal sin’. This is a good point to note that, for example, it would be anti-humanist to tell the grieving Newtown mother that their child was...Army could not support of group of SM’s who wanted to form, organize and gather as a “ Porn Group.” There are limitless ways human beings can assemble

Formal Education: A Catalyst to Nation Building. A Case Study of Nigeria. African Theological Studies. Volume 6

ERIC Educational Resources Information Center

Chimaka, Anthony Ikechukwu

2014-01-01

The smallest and most remote villages in the developing countries are affected by the rapid and seemingly irresistible trend towards globalization. The limitless availability of information however necessitates education to stand out as the key factor for human and national development. But which conditions must be met by societies for education…

JPRS Report, Soviet Union, Political Affairs

DTIC Science & Technology

1989-08-22

vulgar primitive is very much alive. Poets and librettists of low manner are getting ovations which neither Shakespeare nor Pushkin ever dreamed of...which possesses an irrepressible, limitless supply of directorial ingenuity and directorial energy. Several seasons back could we have dreamed of...pay attention to his words. His talks and argumentation on every question are convincing and lucid to those around him. "Those coming to ’sell

Cost-Effectiveness Analysis of Aerial Platforms and Suitable Communication Payloads

DTIC Science & Technology

2014-03-01

High altitude long endurance (HALE) platforms for tactical wireless communications and sensor use in military operations. (Master’s thesis, Naval...the ground, which can offer near limitless endurance. Additionally, running data over wired networks reduces wireless congestion. The most...system that utilizes different wind speeds and wind directions at different altitudes in an attempt to position the balloons for optimal communications

MYBL2 (B-Myb): a central regulator of cell proliferation, cell survival and differentiation involved in tumorigenesis

PubMed Central

Musa, Julian; Aynaud, Marie-Ming; Mirabeau, Olivier; Delattre, Olivier; Grünewald, Thomas GP

2017-01-01

Limitless cell proliferation, evasion from apoptosis, dedifferentiation, metastatic spread and therapy resistance: all these properties of a cancer cell contribute to its malignant phenotype and affect patient outcome. MYBL2 (alias B-Myb) is a transcription factor of the MYB transcription factor family and a physiological regulator of cell cycle progression, cell survival and cell differentiation. When deregulated in cancer cells, MYBL2 mediates the deregulation of these properties. In fact, MYBL2 is overexpressed and associated with poor patient outcome in numerous cancer entities. MYBL2 and players of its downstream transcriptional network can be used as prognostic and/or predictive biomarkers as well as potential therapeutic targets to offer less toxic and more specific anti-cancer therapies in future. In this review, we summarize current knowledge on the physiological roles of MYBL2 and highlight the impact of its deregulation on cancer initiation and progression. PMID:28640249

Oxide nanomaterials: synthetic developments, mechanistic studies, and technological innovations.

PubMed

Patzke, Greta R; Zhou, Ying; Kontic, Roman; Conrad, Franziska

2011-01-24

Oxide nanomaterials are indispensable for nanotechnological innovations, because they combine an infinite variety of structural motifs and properties with manifold morphological features. Given that new oxide materials are almost reported on a daily basis, considerable synthetic and technological work remains to be done to fully exploit this ever increasing family of compounds for innovative nano-applications. This calls for reliable and scalable preparative approaches to oxide nanomaterials and their development remains a challenge for many complex nanostructured oxides. Oxide nanomaterials with special physicochemical features and unusual morphologies are still difficult to access by classic synthetic pathways. The limitless options for creating nano-oxide building blocks open up new technological perspectives with the potential to revolutionize areas ranging from data processing to biocatalysis. Oxide nanotechnology of the 21st century thus needs a strong interplay of preparative creativity, analytical skills, and new ideas for synergistic implementations. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Recirculation: A New Concept to Drive Innovation in Sustainable Product Design for Bio-Based Products.

PubMed

Sherwood, James; Clark, James H; Farmer, Thomas J; Herrero-Davila, Lorenzo; Moity, Laurianne

2016-12-29

Bio-based products are made from renewable materials, offering a promising basis for the production of sustainable chemicals, materials, and more complex articles. However, biomass is not a limitless resource or one without environmental and social impacts. Therefore, while it is important to use biomass and grow a bio-based economy, displacing the unsustainable petroleum basis of energy and chemical production, any resource must be used effectively to reduce waste. Standards have been developed to support the bio-based product market in order to achieve this aim. However, the design of bio-based products has not received the same level of attention. Reported here are the first steps towards the development of a framework of understanding which connects product design to resource efficiency. Research and development scientists and engineers are encouraged to think beyond simple functionality and associate value to the potential of materials in their primary use and beyond.

Experiences of encounters with ayahuasca--"the vine of the soul".

PubMed

Kjellgren, Anette; Eriksson, Anders; Norlander, Torsten

2009-12-01

Ayahuasca is a psychoactive brew used by the indigenous populations of the Amazon. The aim of this qualitative study was to gain insight into the experiences of western users of ayahuasca, as well as to ascertain the experienced meaning that participants felt by their participation. Twenty-five people from Northern Europe with experiences of group sessions with ayahuasca wrote anonymous descriptions of their experiences. The Empirical Phenomenological Psychological method was used for this analysis. The analysis resulted in 33 categories which were assembled into six general themes: (a) motivation and aim, (b) contractile frightening state (c) sudden transformation of the experience, (d) limitless expansive states with transcendental experiences, (f) reflections, and (g) changed worldview and new orientation to life. These themes provided a new structure, called the transcendental circle. Participants reported many positive psychological and physical improvements that indicate that ayahuasca could be of potential interest in the development of new medicines and therapies.

Got black swimming dots in your cell culture? Identification of Achromobacter as a novel cell culture contaminant

PubMed Central

Gray, Jennifer Sue; Birmingham, Janette Marie; Fenton, Jenifer Imig

2009-01-01

ARTICLE SUMMARY Cell culture model systems are utilized for their ease of use, relative inexpensiveness, and potentially limitless sample size. Reliable results cannot be obtained, however, when cultures contain contamination. This report discusses the observation and identification of mobile black specks observed in multiple cell lines. Cultures of the contamination were grown, and DNA was purified from isolated colonies. The 16S rDNA gene was PCR amplified using primers that will amplify the gene from many genera, and then sequenced. Sequencing results matched the members of the genus Achromobacter, bacteria common in the environment. Achromobacter species have been shown to be resistant to multiple antibiotics. Attempts to decontaminate the eukaryotic cell culture used multiple antibiotics at different concentrations. The contaminating Achromobacter was eventually eliminated, without permanently harming the eukaryotic cells, using a combination of the antibiotics ciprofloxacin and piperacillin. PMID:19926304

An effective method for the quantitative detection of porcine endogenous retrovirus in pig tissues.

PubMed

Zhang, Peng; Yu, Ping; Wang, Wei; Zhang, Li; Li, Shengfu; Bu, Hong

2010-05-01

Xenotransplantation shows great promise for providing a virtually limitless supply of cells, tissues, and organs for a variety of therapeutical procedures. However, the potential of porcine endogenous retrovirus (PERV) as a human-tropic pathogen, particularly as a public health risk, is a major concern for xenotransplantation. This study focus on the detection of copy number in various tissues and organs in Banna Minipig Inbreed (BMI) from 2006 to 2007 in West China Hospital, Sichuan University. Real-time quantitative polymerase chain reaction (SYBR Green I) was performed in this study. The results showed that the pol gene had the most copy number in tissues compared with gag, envA, and envB. Our experiment will offer a rapid and accurate method for the detection of the copy number in various tissues and was especially suitable for the selection of tissues or organs in future clinical xenotransplantation.

Modelling human disease with pluripotent stem cells.

PubMed

Siller, Richard; Greenhough, Sebastian; Park, In-Hyun; Sullivan, Gareth J

2013-04-01

Recent progress in the field of cellular reprogramming has opened up the doors to a new era of disease modelling, as pluripotent stem cells representing a myriad of genetic diseases can now be produced from patient tissue. These cells can be expanded and differentiated to produce a potentially limitless supply of the affected cell type, which can then be used as a tool to improve understanding of disease mechanisms and test therapeutic interventions. This process requires high levels of scrutiny and validation at every stage, but international standards for the characterisation of pluripotent cells and their progeny have yet to be established. Here we discuss the current state of the art with regard to modelling diseases affecting the ectodermal, mesodermal and endodermal lineages, focussing on studies which have demonstrated a disease phenotype in the tissue of interest. We also discuss the utility of pluripotent cell technology for the modelling of cancer and infectious disease. Finally, we spell out the technical and scientific challenges which must be addressed if the field is to deliver on its potential and produce improved patient outcomes in the clinic.

Potential High-Temperature Shape-Memory Alloys Identified in the Ti(Ni,Pt) System

NASA Technical Reports Server (NTRS)

Noebe, Ronald D.; Biles, Tiffany A.; Garg, Anita; Nathal, Michael V.

2004-01-01

"Shape memory" is a unique property of certain alloys that, when deformed (within certain strain limits) at low temperatures, will remember and recover to their original predeformed shape upon heating. It occurs when an alloy is deformed in the low-temperature martensitic phase and is then heated above its transformation temperature back to an austenitic state. As the material passes through this solid-state phase transformation on heating, it also recovers its original shape. This behavior is widely exploited, near room temperature, in commercially available NiTi alloys for connectors, couplings, valves, actuators, stents, and other medical and dental devices. In addition, there are limitless applications in the aerospace, automotive, chemical processing, and many other industries for materials that exhibit this type of shape-memory behavior at higher temperatures. But for high temperatures, there are currently no commercial shape-memory alloys. Although there are significant challenges to the development of high-temperature shape-memory alloys, at the NASA Glenn Research Center we have identified a series of alloy compositions in the Ti-Ni-Pt system that show great promise as potential high-temperature shape-memory materials.

Developing Dependable Software for a System-of-Systems

DTIC Science & Technology

2005-03-01

the combined casualties of Union and Confederate forces totaled 26,134 soldiers on a single day of battle. [48] The war of attrition concept was a...attrition to a transformational concept of full-spectrum dominance: the ability of US forces, operating unilaterally or in combination with...the complex system-of-systems, these possible combinations are practically limitless. System "unravelings" seem to have an intelligence of their own

The Budget Scoring Alternatives Financing Methods for Defense Requirements

DTIC Science & Technology

2007-04-30

The government grants a franchise to a private partner to finance, design, build and operate a facility for a specific period of time. Ownership of...of an automobile from Avis implies no ownership . However, leases can be structured in an almost limitless number of complex arrangements in which...satisfy the following stringent criteria: Ownership of the asset remains with the lessor during the term of the lease and is not transferred to the

A Proposal for a Study of Bulimia Among Women in the United States Air Force

DTIC Science & Technology

1988-12-01

to be effective (7). Activities on many bases are limitless and frequently include softball, basketball, football, baseball, volleyball, soccer ...34most authorities recognize that the recommended body weight of these tables does not provide an accurate assessment of body fat because of the wide...how many die undiagnosed. Starvation, -uic4 - inadequate potassium intake and stomach perforation from insertion of a nasogastric tube are the more

Budget Scoring: An Impediment to Alternative Financing

DTIC Science & Technology

2007-09-06

from Avis implies no ownership . However, leases can be structured in an almost limitless number of complex arrangements in which all terms are... Ownership of the asset remains with the lessor during the term of the lease and is not transferred to the Government at or shortly after the end of...not built to unique specification for the Government as lessee. 6) There is a private-sector market for the asset. 7) Risks of ownership of the

Research Monograph on Federal International Economic Emergency Planning.

DTIC Science & Technology

1985-10-31

interrelates national and international factors in world food supply. 1 1 1 I I I I I -3- 1 I.B. PARAMETERS OF THIS STUDY Assigning a scope to a study...of their specialization. Thus "air" is typically 3 considered a limitless resource, and therefore a non-economic good, whereas food , clothing and...rights to use such information in the form of licenses, patents, franchises , etc. I Accordingly, for purposes of this study, we shall define economics

The search for new amphiphiles: synthesis of a modular, high-throughput library

PubMed Central

Feast, George C; Lepitre, Thomas; Mulet, Xavier; Conn, Charlotte E; Hutt, Oliver E

2014-01-01

Summary Amphiphilic compounds are used in a variety of applications due to their lyotropic liquid-crystalline phase formation, however only a limited number of compounds, in a potentially limitless field, are currently in use. A library of organic amphiphilic compounds was synthesised consisting of glucose, galactose, lactose, xylose and mannose head groups and double and triple-chain hydrophobic tails. A modular, high-throughput approach was developed, whereby head and tail components were conjugated using the copper-catalysed azide–alkyne cycloaddition (CuAAC) reaction. The tails were synthesised from two core alkyne-tethered intermediates, which were subsequently functionalised with hydrocarbon chains varying in length and degree of unsaturation and branching, while the five sugar head groups were selected with ranging substitution patterns and anomeric linkages. A library of 80 amphiphiles was subsequently produced, using a 24-vial array, with the majority formed in very good to excellent yields. A preliminary assessment of the liquid-crystalline phase behaviour is also presented. PMID:25161714

The search for new amphiphiles: synthesis of a modular, high-throughput library.

PubMed

Feast, George C; Lepitre, Thomas; Mulet, Xavier; Conn, Charlotte E; Hutt, Oliver E; Savage, G Paul; Drummond, Calum J

2014-01-01

Amphiphilic compounds are used in a variety of applications due to their lyotropic liquid-crystalline phase formation, however only a limited number of compounds, in a potentially limitless field, are currently in use. A library of organic amphiphilic compounds was synthesised consisting of glucose, galactose, lactose, xylose and mannose head groups and double and triple-chain hydrophobic tails. A modular, high-throughput approach was developed, whereby head and tail components were conjugated using the copper-catalysed azide-alkyne cycloaddition (CuAAC) reaction. The tails were synthesised from two core alkyne-tethered intermediates, which were subsequently functionalised with hydrocarbon chains varying in length and degree of unsaturation and branching, while the five sugar head groups were selected with ranging substitution patterns and anomeric linkages. A library of 80 amphiphiles was subsequently produced, using a 24-vial array, with the majority formed in very good to excellent yields. A preliminary assessment of the liquid-crystalline phase behaviour is also presented.

Future Directions for Examination of Brain Networks in Neurodevelopmental Disorders.

PubMed

Uddin, Lucina Q; Karlsgodt, Katherine H

2018-01-01

Neurodevelopmental disorders are associated with atypical development and maturation of brain networks. A recent focus on human connectomics research and the growing popularity of open science initiatives has created the ideal climate in which to make real progress toward understanding the neurobiology of disorders affecting youth. Here we outline future directions for neuroscience researchers examining brain networks in neurodevelopmental disorders, highlighting gaps in the current literature. We emphasize the importance of leveraging large neuroimaging and phenotypic data sets recently made available to the research community, and we suggest specific novel methodological approaches, including analysis of brain dynamics and structural connectivity, that have the potential to produce the greatest clinical insight. Transdiagnostic approaches will also become increasingly necessary as the Research Domain Criteria framework put forth by the National Institute of Mental Health permeates scientific discourse. During this exciting era of big data and increased computational sophistication of analytic tools, the possibilities for significant advancement in understanding neurodevelopmental disorders are limitless.

The Peace Game: A Data-Driven Evaluation of a Software-Based Model of the Effects of Modern Conflict on Populations

DTIC Science & Technology

2015-09-01

Most of these early computer games were just digital depictions of a board game. The computers were generally used as a giant calculator that helped...limitless. Digital output of “what happened” allows game players and decision makers to collect and analyze every part of the game without transcription...there was a dispute over voter eligibility. Missiriya nomads , who are loyal to Sudan, spend several months of the year in Abyei grazing their cattle

Flights of a spacecraft with a solar sail out of ecliptic plane

NASA Astrophysics Data System (ADS)

Polyakhova, Elena; Starkov, Vladimir; Stepenko, Nikolai

2018-05-01

Solar sailing is an unique form of spacecraft (SC) propulsion that uses the free and limitless supply of photons from the Sun. The investigation of near-the-Sun space properties is of the great scientific interest. It can be realized by help of solar sailing. We present the numerical simulation of several closed modelled trajectories of a spacecraft with a controlled solar sail to reach out of ecliptic plane, to flight over the Sun north and south poles and return to the Earth.

The Art of Living with NZT and ICT: Dialectics of an Artistic Case Study.

PubMed

Zwart, Hub

2017-01-01

I wholeheartedly sympathize conceptually with Coeckelbergh's paper. The dialectical relationship between vulnerability and technology constitutes the core of Hegel's Master and Slave (the primal scene of contemporary philosophy). Yet, the empirical dimension is underdeveloped and Coeckelbergh's ideas could profit from exposure to case studies. Building on a movie/novel ( Limitless ) devoted to vulnerability coping and living with ICT, I challenge the claim that modern heroism entails overcoming vulnerability with the help of enhancement and computers.

The Promise and the Challenge of Space Solar Power in the 21st Century: Picking up the Gauntlet

NASA Astrophysics Data System (ADS)

Mankins, John C.

2002-01-01

The history of human civilization is a history of great infrastructure. Chief among these developments have been advances in power, transport, and communications. Without dramatic and steady advances in these critical systems during the past two hundred years-- especially in the available sources of power--the world would be a drastically poorer and harsher home for humanity. At the same time, through the global use of existing energy technologies humanity is rapidly consuming irreplaceable fossil resources as well as changing the environment and the climate for the world itself. Both must raise concerns about the long-term sustainability of the infrastructures that have enabled our world. The importance of abundant and affordable energy in space exploration and development is equally clear. Current missions of exploration and scientific discovery are narrowly constrained by a lack of energy. Future, even more ambitious missions will never be realized without new, reliable and less expensive sources of energy. Even more, the potential emergence of new space industries such as space tourism, manufacturing in space, solar power satellites (SPS) and others, will depend on advances in space power systems just as much as they will on progress in space transportation. Recent studies and technological advances suggest that large-scale space solar power (SSP) systems may enable progress in both arenas during the next several decades. Of course, there are tremendous engineering and technological barriers that must be surmounted to someday make large SSP systems possible. Diverse areas of technology must be advanced. Some of these include space transportation, solar power generation, wireless power transmission, robotics, structural concepts and materials, and others. Nevertheless, there are potential benefits in the offing that seem to many to make challenging even these daunting technical barriers worthwhile--and perhaps essential. Unfortunately, the political and programmatic hurdles faced by SSP often seem even greater than the technical difficulties to be faced. The great engineering and technologies projects of the past century provide important lessons--both good and bad-- that bear directly on this challenge. The Peter Glaser Lecture for 2002 will examine from a strategic perspective the challenge and the promise of space solar power, and--in the context of historical examples--suggest directions to advance this vision of almost limitless, clean energy in space and from space for the Earth.

Fire safety in the operating room.

PubMed

Rinder, Christine Stowe

2008-12-01

Elimination of flammable anesthetic gases has had little effect on operating-room fires except to change their etiology. Electrocautery and lasers, in an oxygen-enriched environment, can ignite even the most fire-resistant materials, including the patient, and the fire triad possibilities in the operating room are nearly limitless. This review will: identify operating room contents capable of acting as ignition/oxidizer/fuel sources, highlight operating room items that are uniquely potent fire triad contributors, and operating room identify settings where fire risk is enhanced by proximity of triad components in time or space. Anesthesiologists are cognizant of the risk of airway surgery fires due to laser ignition of the endotracheal tube and/or its contents. Recently, however, head/neck surgery under monitored anesthesia care has emerged as a high-risk setting for operating room fires; burn injuries represent 20% of monitored anesthesia care-related malpractice claims, 95% of which involved head/neck surgery. Operating room fires are infrequent but catastrophic. Operating room fire prevention depends on: (a)understanding how fire triad elements interact to create a fire, (b) recognizing how standard operating-room equipment, materials, and supplemental oxygen can become one of those elements, and (c) vigilance for circumstances that bring fire triad elements into close proximity.

Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells

PubMed Central

Varela, Christine; Denis, Jérôme Alexandre; Polentes, Jérôme; Feyeux, Maxime; Aubert, Sophie; Champon, Benoite; Piétu, Geneviève; Peschanski, Marc; Lefort, Nathalie

2012-01-01

Human pluripotent stem cells offer a limitless source of cells for regenerative medicine. Neural derivatives of human embryonic stem cells (hESCs) are currently being used for cell therapy in 3 clinical trials. However, hESCs are prone to genomic instability, which could limit their clinical utility. Here, we report that neural differentiation of hESCs systematically produced a neural stem cell population that could be propagated for more than 50 passages without entering senescence; this was true for all 6 hESC lines tested. The apparent spontaneous loss of evolution toward normal senescence of somatic cells was associated with a jumping translocation of chromosome 1q. This chromosomal defect has previously been associated with hematologic malignancies and pediatric brain tumors with poor clinical outcome. Neural stem cells carrying the 1q defect implanted into the brains of rats failed to integrate and expand, whereas normal cells engrafted. Our results call for additional quality controls to be implemented to ensure genomic integrity not only of undifferentiated pluripotent stem cells, but also of hESC derivatives that form cell therapy end products, particularly neural lines. PMID:22269325

Derivation of porcine pluripotent stem cells for biomedical research.

PubMed

Shiue, Yow-Ling; Yang, Jenn-Rong; Liao, Yu-Jing; Kuo, Ting-Yung; Liao, Chia-Hsin; Kang, Ching-Hsun; Tai, Chein; Anderson, Gary B; Chen, Lih-Ren

2016-07-01

Pluripotent stem cells including embryonic stem cells (ESCs), embryonic germ cells (EGCs), and induced pluripotent stem cells (iPSCs) are capable of self-renew and limitlessly proliferating in vitro with undifferentiated characteristics. They are able to differentiate in vitro, spontaneously or responding to suitable signals, into cells of all three primary germ layers. Consequently, these pluripotent stem cells will be valuable sources for cell replacement therapy in numerous disorders. However, the promise of human ESCs and EGCs is cramped by the ethical argument about destroying embryos and fetuses for cell line creation. Moreover, there are still carcinogenic risks existing toward the goal of clinical application for human ESCs, EGCs, and iPSCs. Therefore, a suitable animal model for stem cell research will benefit the further development of human stem cell technology. The pigs, on the basis of their similarity in anatomy, immunology, physiology, and biochemical properties, have been wide used as model animals in the study of various human diseases. The development of porcine pluripotent stem cell lines will hold the opportunity to provide an excellent material for human counterpart to the transplantation in biomedical research and further development of cell-based therapeutic strategy. Copyright © 2016 Elsevier Inc. All rights reserved.

Microbial forensics: fiber optic microarray subtyping of Bacillus anthracis

NASA Astrophysics Data System (ADS)

Shepard, Jason R. E.

2009-05-01

The past decade has seen increased development and subsequent adoption of rapid molecular techniques involving DNA analysis for detection of pathogenic microorganisms, also termed microbial forensics. The continued accumulation of microbial sequence information in genomic databases now better positions the field of high-throughput DNA analysis to proceed in a more manageable fashion. The potential to build off of these databases exists as technology continues to develop, which will enable more rapid, cost effective analyses. This wealth of genetic information, along with new technologies, has the potential to better address some of the current problems and solve the key issues involved in DNA analysis of pathogenic microorganisms. To this end, a high density fiber optic microarray has been employed, housing numerous DNA sequences simultaneously for detection of various pathogenic microorganisms, including Bacillus anthracis, among others. Each organism is analyzed with multiple sequences and can be sub-typed against other closely related organisms. For public health labs, real-time PCR methods have been developed as an initial preliminary screen, but culture and growth are still considered the gold standard. Technologies employing higher throughput than these standard methods are better suited to capitalize on the limitless potential garnered from the sequence information. Microarray analyses are one such format positioned to exploit this potential, and our array platform is reusable, allowing repetitive tests on a single array, providing an increase in throughput and decrease in cost, along with a certainty of detection, down to the individual strain level.

Straight talk with... Eric Green. Interview by Erica Westly.

PubMed

Green, Eric

2010-01-01

Eric Green, the new head of the US National Human Genome Research Institute (NHGRI), has been involved with genomics since the term was first coined in the 1980s. He started at the US National Institutes of Health (NIH) as a postdoc and was a key contributor to the Human Genome Project. Nearly a decade ago, when Green was part of a team that produced one of the first human genome sequences, the potential for genomics-related medical applications seemed limitless. But most disorders have proved to be too complex to benefit from our current understanding of genomics, and some critics have argued that researchers have put too much emphasis on uncovering the genetic underpinnings of diseases. Recent demand for comparative effectiveness research in medicine has further complicated the debate, leading former head of NHGRI Francis Collins to worry that genomic differences could get "lost in the wash." Erica Westly spoke with Green about where he sees the genomics field heading and what role he thinks the NHGRI should have in the American health care system.

Simulation on the Performance of a Driven Fan Made by Polyester/Epoxy interpenetrate polymer network (IPN)

NASA Astrophysics Data System (ADS)

Fahrul Hassan, Mohd; Jamri, Azmil; Nawawi, Azli; Zaini Yunos, Muhamad; Fauzi Ahmad, Md; Adzila, Sharifah; Nasrull Abdol Rahman, Mohd

2017-08-01

The main purpose of this study is to investigate the performance of a driven fan design made by Polyester/Epoxy interpenetrate polymer network (IPN) material that specifically used for turbocharger compressor. Polyester/Epoxy IPN is polymer plastics that was used as replacements for traditional polymers and has been widely used in a variety of applications because of their limitless conformations. Simulation based on several parameters which are air pressure, air velocity and air temperature have been carried out for a driven fan design performance of two different materials, aluminum alloy (existing driven fan design) and Polyester/Epoxy IPN using SolidWorks Flow Simulation software. Results from both simulations were analyzed and compared where both materials show similar performance in terms of air pressure and air velocity due to similar geometric and dimension, but Polyester/Epoxy IPN produces lower air temperature than aluminum alloy. This study shows a preliminary result of the potential Polyester/Epoxy IPN to be used as a driven fan design material. In the future, further studies will be conducted on detail simulation and experimental analysis.

Disruptive Innovation Can Prevent the Next Pandemic.

PubMed

Shaikh, Affan T; Ferland, Lisa; Hood-Cree, Robert; Shaffer, Loren; McNabb, Scott J N

2015-01-01

Public health surveillance (PHS) is at a tipping point, where the application of novel processes, technologies, and tools promise to vastly improve efficiency and effectiveness. Yet twentieth century, entrenched ideology and lack of training results in slow uptake and resistance to change. The term disruptive innovation - used to describe advances in technology and processes that change existing markets - is useful to describe the transformation of PHS. Past disruptive innovations used in PHS, such as distance learning, the smart phone, and field-based laboratory testing have outpaced older services, practices, and technologies used in the traditional classroom, governmental offices, and personal communication, respectively. Arguably, the greatest of these is the Internet - an infrastructural innovation that continues to enable exponential benefits in seemingly limitless ways. Considering the Global Health Security Agenda and facing emerging and reemerging infectious disease threats, evolving environmental and behavioral risks, and ever changing epidemiologic trends, PHS must transform. Embracing disruptive innovation in the structures and processes of PHS can be unpredictable. However, it is necessary to strengthen and unlock the potential to prevent, detect, and respond.

Impact of pore size on the sorption of uranyl under seawater conditions

DOE PAGES

Mayes, Richard T.; Gorka, Joanna; Dai, Sheng

2016-04-05

The extraction of uranium from seawater has received significant interest recently, because of the possibility of a near-limitless supply of uranium to fuel the nuclear power industry. While sorbent development has focused primarily on polymeric sorbents, nanomaterials represent a new area that has the potential to surpass the current polymeric sorbents, because of the high surface areas that are possible. Mesoporous carbon materials are a stable, high-surface-area material capable of extracting various chemical species from a variety of environments. Herein, we report the use of a dual templating process to understand the effect of pore size on the adsorption ofmore » uranyl ions from a uranyl brine consisting of seawater-relevant sodium, chloride, and bicarbonate ions. It was found that pore size played a more significant role in the effective use of the grafted polymer, leading to higher uranium capacities than the surface area. Furthermore, the pore size must be tailored to meet the demands of the extraction medium and analyte metal to achieve efficacy as an adsorbent.« less

Using DNA-labelled nano- and microparticles to track particle transport in the environment

NASA Astrophysics Data System (ADS)

McNew, Coy; Wang, Chaozi; Dahlke, Helen; Lyon, Steve; Walter, Todd

2017-04-01

By utilizing bio-molecular nanotechnology developed for nano-medicines and drug delivery, we are able to produce DNA-labelled nano- and microparticle tracers for use in a myriad of environmental systems. The use of custom sequenced DNA allows for the fabrication of an enormous number of uniquely labelled tracers with identical transport properties (approximately 1.61 x 1060 unique sequences), each independently quantifiable, that can be applied simultaneously in any hydrologic system. By controlling the fabrication procedure to produce particles of custom size and charge, we are able to tag each size-charge combination uniquely in order to directly probe the effect of these variables on the transport properties of the particles. Here we present our methods for fabrication, extraction, and analysis of the DNA nano- and microparticle tracers, along with results from several successful applications of the tracers, including transport and retention analysis at the lab, continuum, and field scales. To date, our DNA-labelled nano- and microparticle tracers have proved useful in surface and subsurface water applications, soil retention, and even subglacial flow pathways. The range of potential applications continue to prove nearly limitless.

PACS project management utilizing web-based tools

NASA Astrophysics Data System (ADS)

Patel, Sunil; Levin, Brad; Gac, Robert J., Jr.; Harding, Douglas, Jr.; Chacko, Anna K.; Radvany, Martin; Romlein, John R.

2000-05-01

As Picture Archiving and Communications Systems (PACS) implementations become more widespread, the management of deploying large, multi-facility PACS will become a more frequent occurrence. The tools and usability of the World Wide Web to disseminate project management information obviates time, distance, participant availability, and data format constraints, allowing for the effective collection and dissemination of PACS planning, implementation information, for a potentially limitless number of concurrent PACS sites. This paper will speak to tools, such as (1) a topic specific discussion board, (2) a 'restricted' Intranet, within a 'project' Intranet. We will also discuss project specific methods currently in use in a leading edge, regional PACS implementation concerning the sharing of project schedules, physical drawings, images of implementations, site-specific data, point of contacts lists, project milestones, and a general project overview. The individual benefits realized for the end user from each tool will also be covered. These details will be presented, balanced with a spotlight on communication as a critical component of any project management undertaking. Using today's technology, the web arguably provides the most cost and resource effective vehicle to facilitate the broad based, interactive sharing of project information.

Ocean thermal plantships for production of ammonia as the hydrogen carrier.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Panchal, C.B.; Pandolfini, P. P.; Kumm, W. H.

2009-12-02

Conventional petroleum, natural gas, and coal are the primary sources of energy that have underpinned modern civilization. Their continued availability in the projected quantities required and the impacts of emission of greenhouse gases (GHGs) on the environment are issues at the forefront of world concerns. New primary sources of energy are being sought that would significantly reduce the emissions of GHGs. One such primary source that can help supply energy, water, and fertilizer without GHG emissions is available in the heretofore unexploited thermal gradients of the tropical oceans. The world's oceans are the largest natural collector and reservoir of solarmore » energy. The potential of ocean energy is limitless for producing base-load electric power or ammonia as the hydrogen carrier and fresh water from seawater. However, until now, ocean energy has been virtually untapped. The general perception is that ocean thermal energy is limited to tropical countries. Therefore, the full potential of at-sea production of (1) ammonia as a hydrogen carrier and (2) desalinated water has not been adequately evaluated. Using ocean thermal plantships for the at-sea co-production of ammonia as a hydrogen carrier and desalinated water offer potential energy, environmental, and economic benefits that support the development of the technology. The introduction of a new widespread solution to our projected energy supply requires lead times of a decade or more. Although continuation of the ocean thermal program from the 1970s would likely have put us in a mitigating position in the early 2000s, we still have a window of opportunity to dedicate some of our conventional energy sources to the development of this renewable energy by the time new sources would be critically needed. The primary objective of this project is to evaluate the technical and economic viability of ocean thermal plantships for the production of ammonia as the hydrogen carrier. This objective is achieved by completing project tasks that consist of updating the John Hopkins University/Applied Physics Laboratory (JHU/APL) pilot plantship design and extrapolating it to commercial plantships, evaluating a new energy-efficient ammonia synthesis process, evaluating the co-production of desalinated water on plantships, and developing a conceptual design of a satellite plantships system for commercial-scale ammonia production. In addition, an industrial workshop was organized to present the results and develop future goals for commercialization of ocean thermal plantships by 2015. The following goals, arranged in chronological order, were examined at the workshop: (1) Global displacement of petroleum-fuel-based (diesel, fuel oil, naphtha) power generation for freeing up these fuels for transportation, chemical feedstock, and other high-valued uses; (2) At-sea production of desalinated water for regions of critical water shortages; (3) Displacement of carbon-based feed stocks and energy for production of ammonia fertilizers; (4) Development of hydrogen supply to allow economic processing of heavy crude oils and upgrading oil sands; (5) Development of ammonia-fueled distributed energy to displace natural-gas fueled power generation to free up natural gas for higher-value uses and the mitigation of issues associated with imported liquefied natural gas (LNG); and (6) Use of ammonia as a hydrogen carrier for transportation.« less

Biomimetic heterogenous elastic tissue development.

PubMed

Tsai, Kai Jen; Dixon, Simon; Hale, Luke Richard; Darbyshire, Arnold; Martin, Daniel; de Mel, Achala

2017-01-01

There is an unmet need for artificial tissue to address current limitations with donor organs and problems with donor site morbidity. Despite the success with sophisticated tissue engineering endeavours, which employ cells as building blocks, they are limited to dedicated labs suitable for cell culture, with associated high costs and long tissue maturation times before available for clinical use. Direct 3D printing presents rapid, bespoke, acellular solutions for skull and bone repair or replacement, and can potentially address the need for elastic tissue, which is a major constituent of smooth muscle, cartilage, ligaments and connective tissue that support organs. Thermoplastic polyurethanes are one of the most versatile elastomeric polymers. Their segmented block copolymeric nature, comprising of hard and soft segments allows for an almost limitless potential to control physical properties and mechanical behaviour. Here we show direct 3D printing of biocompatible thermoplastic polyurethanes with Fused Deposition Modelling, with a view to presenting cell independent in-situ tissue substitutes. This method can expeditiously and economically produce heterogenous, biomimetic elastic tissue substitutes with controlled porosity to potentially facilitate vascularisation. The flexibility of this application is shown here with tubular constructs as exemplars. We demonstrate how these 3D printed constructs can be post-processed to incorporate bioactive molecules. This efficacious strategy, when combined with the privileges of digital healthcare, can be used to produce bespoke elastic tissue substitutes in-situ, independent of extensive cell culture and may be developed as a point-of-care therapy approach.

Bringing Up Baby

NASA Technical Reports Server (NTRS)

Guastaferro, Angelo

2004-01-01

In 1977, I had just finished eight years on the Viking program, which was just a marvelously rich, fascinating experience, using the most up-to-date, sophisticated management techniques, under an outstanding leader named Jim Martin. After that, you could say the opportunities available to me within NASA in some ways were limitless. I remember quite vividly when I got the phone call from Ed Cortright, who was the Langley Center Director at the time, with news about my next assignment. He asked me to come to the aid of a project that was in trouble, the Rotor Systems Research Aircraft (RSRA).

Britain's nuclear secrets: inside Sellafield

NASA Astrophysics Data System (ADS)

Marino, Antigone

2017-11-01

Lying on the remote north west coast of England, Sellafield is one of the most secret places in UK, and even one of the most controversial nuclear fuel reprocessing and nuclear decommissioning sites in Britain. The film director Tim Usborne let us enter into the world's first nuclear power station, revealing Britain's attempts to harness the almost limitless power of the atom. It is precisely the simplicity and the scientific rigor used in the film to speak of nuclear, which led this documentary to win the Physics Prize supported by the European Physical Society at the European Science TV and New Media Festival and Awards 2016.

Frameless, image-guided stereotactic radiosurgery.

PubMed

Steffey-Stacy, Emily Cassandra

2006-11-01

To trace the evolution from frame-based to frameless image-guided SRS, to discuss the basic radiobiological principle of fractionation, current clinical trial data, and procedural components of the treatment plan. Nursing and medical literature, neurosurgical textbooks, and select internet sites. The CyberKnife (Accuray, Sunnyvale, CA) is the newest machine added to the technologic armamentarium of patient care. Its capacities are only beginning to be explored and the possibilities are limitless, giving hope to countless persons. Technologic advances have necessitated a diversification of nursing roles. Coordination of patient care services requires nurses to advance their knowledge of frameless, image-guided SRS.

Multimedia content description framework

NASA Technical Reports Server (NTRS)

Bergman, Lawrence David (Inventor); Mohan, Rakesh (Inventor); Li, Chung-Sheng (Inventor); Smith, John Richard (Inventor); Kim, Michelle Yoonk Yung (Inventor)

2003-01-01

A framework is provided for describing multimedia content and a system in which a plurality of multimedia storage devices employing the content description methods of the present invention can interoperate. In accordance with one form of the present invention, the content description framework is a description scheme (DS) for describing streams or aggregations of multimedia objects, which may comprise audio, images, video, text, time series, and various other modalities. This description scheme can accommodate an essentially limitless number of descriptors in terms of features, semantics or metadata, and facilitate content-based search, index, and retrieval, among other capabilities, for both streamed or aggregated multimedia objects.

Thermal modeling for pulsed radiofrequency ablation: analytical study based on hyperbolic heat conduction.

PubMed

López Molina, Juan A; Rivera, María J; Trujillo, Macarena; Berjano, Enrique J

2009-04-01

The objectives of this study were to model the temperature progress of a pulsed radiofrequency (RF) power during RF heating of biological tissue, and to employ the hyperbolic heat transfer equation (HHTE), which takes the thermal wave behavior into account, and compare the results to those obtained using the heat transfer equation based on Fourier theory (FHTE). A theoretical model was built based on an active spherical electrode completely embedded in the biological tissue, after which HHTE and FHTE were analytically solved. We found three typical waveforms for the temperature progress depending on the relations between the dimensionless duration of the RF pulse delta(a) and the expression square root of lambda(rho-1), with lambda as the dimensionless thermal relaxation time of the tissue and rho as the dimensionless position. In the case of a unique RF pulse, the temperature at any location was the result of the overlapping of two different heat sources delayed for a duration delta(a) (each heat source being produced by a RF pulse of limitless duration). The most remarkable feature in the HHTE analytical solution was the presence of temperature peaks traveling through the medium at a finite speed. These peaks not only occurred during the RF power switch-on period but also during switch off. Finally, a physical explanation for these temperature peaks is proposed based on the interaction of forward and reverse thermal waves. All-purpose analytical solutions for FHTE and HHTE were obtained during pulsed RF heating of biological tissues, which could be used for any value of pulsing frequency and duty cycle.

JobCenter: an open source, cross-platform, and distributed job queue management system optimized for scalability and versatility.

PubMed

Jaschob, Daniel; Riffle, Michael

2012-07-30

Laboratories engaged in computational biology or bioinformatics frequently need to run lengthy, multistep, and user-driven computational jobs. Each job can tie up a computer for a few minutes to several days, and many laboratories lack the expertise or resources to build and maintain a dedicated computer cluster. JobCenter is a client-server application and framework for job management and distributed job execution. The client and server components are both written in Java and are cross-platform and relatively easy to install. All communication with the server is client-driven, which allows worker nodes to run anywhere (even behind external firewalls or "in the cloud") and provides inherent load balancing. Adding a worker node to the worker pool is as simple as dropping the JobCenter client files onto any computer and performing basic configuration, which provides tremendous ease-of-use, flexibility, and limitless horizontal scalability. Each worker installation may be independently configured, including the types of jobs it is able to run. Executed jobs may be written in any language and may include multistep workflows. JobCenter is a versatile and scalable distributed job management system that allows laboratories to very efficiently distribute all computational work among available resources. JobCenter is freely available at http://code.google.com/p/jobcenter/.

Chromosome microduplication in somatic cells decreases the genetic stability of human reprogrammed somatic cells and results in pluripotent stem cells.

PubMed

Yu, Yang; Chang, Liang; Zhao, Hongcui; Li, Rong; Fan, Yong; Qiao, Jie

2015-05-12

Human pluripotent stem cells, including cloned embryonic and induced pluripotent stem cells, offer a limitless cellular source for regenerative medicine. However, their derivation efficiency is limited, and a large proportion of cells are arrested during reprogramming. In the current study, we explored chromosome microdeletion/duplication in arrested and established reprogrammed cells. Our results show that aneuploidy induced by somatic cell nuclear transfer technology is a key factor in the developmental failure of cloned human embryos and primary colonies from implanted cloned blastocysts and that expression patterns of apoptosis-related genes are dynamically altered. Overall, ~20%-53% of arrested primary colonies in induced plurpotent stem cells displayed aneuploidy, and upregulation of P53 and Bax occurred in all arrested primary colonies. Interestingly, when somatic cells with pre-existing chromosomal mutations were used as donor cells, no cloned blastocysts were obtained, and additional chromosomal mutations were detected in the resulting iPS cells following long-term culture, which was not observed in the two iPS cell lines with normal karyotypes. In conclusion, aneuploidy induced by the reprogramming process restricts the derivation of pluripotent stem cells, and, more importantly, pre-existing chromosomal mutations enhance the risk of genome instability, which limits the clinical utility of these cells.

AIDing Chromatin and Transcription-Coupled Orchestration of Immunoglobulin Class-Switch Recombination

PubMed Central

Vaidyanathan, Bharat; Yen, Wei-Feng; Pucella, Joseph N.; Chaudhuri, Jayanta

2014-01-01

Secondary diversification of the antibody repertoire upon antigenic challenge, in the form of immunoglobulin heavy chain (IgH) class-switch recombination (CSR) endows mature, naïve B cells in peripheral lymphoid organs with a limitless ability to mount an optimal humoral immune response, thus expediting pathogen elimination. CSR replaces the default constant (CH) region exons (Cμ) of IgH with any of the downstream CH exons (Cγ, Cε, or Cα), thereby altering effector functions of the antibody molecule. This process depends on, and is orchestrated by, activation-induced deaminase (AID), a DNA cytidine deaminase that acts on single-stranded DNA exposed during transcription of switch (S) region sequences at the IgH locus. DNA lesions thus generated are processed by components of several general DNA repair pathways to drive CSR. Given that AID can instigate DNA lesions and genomic instability, stringent checks are imposed that constrain and restrict its mutagenic potential. In this review, we will discuss how AID expression and substrate specificity and activity is rigorously enforced at the transcriptional, post-transcriptional, post-translational, and epigenetic levels, and how the DNA-damage response is choreographed with precision to permit targeted activity while limiting bystander catastrophe. PMID:24734031

EPR Studies of Magnetically Dilute Ga-Doped Single Crystals of Fe18 Antiferromagnetic Molecular Wheels

NASA Astrophysics Data System (ADS)

Henderson, John; Ramsey, Christopher; Del Barco, Enrique; Stamatatos, Theocharis; Christou, George

2008-03-01

Studies of the quantum dynamics of the electron spins in solid state systems has gained considerable interest recently due to their potential for use as quantum computing substrates. One class of materials, molecular magnets, are of particular importance, owing to the seemingly limitless array of spin configurations due to synthetic chemical flexibility. Efforts are currently devoted to minimizing decoherence times by diminishing dipolar effects. In this regard, we have carried out EPR measurements on small single crystals of 0.5% Ga doped Fe18 molecular antiferromagnetic wheels at temperatures down to 300 mK using planar resonators patterned on GaAs wafers. This system constitutes a dilute sample of S = 5/2 molecules dispersed within a sea of S = 0 (at low temperature) molecules, which significantly reduces dipolar interactions and might provide a means of observing Rabi oscillations in crystals of molecular magnets. Detailed angular dependence studies reveal significant anisotropy with D = 500 mK and E = 20 mK. The presence of second order anisotropy (E) is very unusual for such a high symmetry system and its interpretation will be discussed. Pulsed-EPR measurements and doping concentration dependence will also be discussed.

Antibacterial activity of local herbs collected from Murree (Pakistan) against multi-drug resistant Klebsiella pneumonae, E. coli and methyciline resistant Staphylococcus aureus.

PubMed

Mansoor, Qaisar; Shaheen, Saira; Javed, Uzma; Shaheen, Uzma; Iqrar, Irum; Ismail, Muhammad

2013-07-01

Exploring healing power in plants emerged in prehistory of human civilization. Sustaining good health has been achieved over the millions of years by use of plant products in various traditional sockets. A major contribution of medicinal plants to health care systems is their limitless possession of bioactive components that stimulate explicit physiological actions. Luckily Pakistan is blessed with huge reservoir of plants with medicinal potential and some of them; we focused in this study for their medicinal importance.In this study we checked the antibacterial activity inherent in Ricinus communis, Solanum nigrum, Dodonaea viscose and Berberis lyceum extracts for multidrug resistance bacterial strains Klebsiella pneumonae, E. coli and methyciline resistant Staphylococcus aureus. MRSA showed sensitivity for Ricinus communis. Multidrug resistant Klebsiella pneumonae was sensitive with Pine roxburgii and Ricinus communis but weakly susceptible for Solanum nigrum. Multidrug resistant E. coli was resistant to all plant extracts. Treatment of severe infections caused by the bacterial strains used in this study with Ricinus communis, Pine roxburgii and Solanum nigrum can lower the undesired side effects of synthetic medicine and also reduce the economic burden.

Can composite digital monitoring biomarkers come of age? A framework for utilization.

PubMed

Kovalchick, Christopher; Sirkar, Rhea; Regele, Oliver B; Kourtis, Lampros C; Schiller, Marie; Wolpert, Howard; Alden, Rhett G; Jones, Graham B; Wright, Justin M

2017-12-01

The application of digital monitoring biomarkers in health, wellness and disease management is reviewed. Harnessing the near limitless capacity of these approaches in the managed healthcare continuum will benefit from a systems-based architecture which presents data quality, quantity, and ease of capture within a decision-making dashboard. A framework was developed which stratifies key components and advances the concept of contextualized biomarkers. The framework codifies how direct, indirect, composite, and contextualized composite data can drive innovation for the application of digital biomarkers in healthcare. The de novo framework implies consideration of physiological, behavioral, and environmental factors in the context of biomarker capture and analysis. Application in disease and wellness is highlighted, and incorporation in clinical feedback loops and closed-loop systems is illustrated. The study of contextualized biomarkers has the potential to offer rich and insightful data for clinical decision making. Moreover, advancement of the field will benefit from innovation at the intersection of medicine, engineering, and science. Technological developments in this dynamic field will thus fuel its logical evolution guided by inputs from patients, physicians, healthcare providers, end-payors, actuarists, medical device manufacturers, and drug companies.

A flexible and economical barcoding approach for highly multiplexed amplicon sequencing of diverse target genes

PubMed Central

Herbold, Craig W.; Pelikan, Claus; Kuzyk, Orest; Hausmann, Bela; Angel, Roey; Berry, David; Loy, Alexander

2015-01-01

High throughput sequencing of phylogenetic and functional gene amplicons provides tremendous insight into the structure and functional potential of complex microbial communities. Here, we introduce a highly adaptable and economical PCR approach to barcoding and pooling libraries of numerous target genes. In this approach, we replace gene- and sequencing platform-specific fusion primers with general, interchangeable barcoding primers, enabling nearly limitless customized barcode-primer combinations. Compared to barcoding with long fusion primers, our multiple-target gene approach is more economical because it overall requires lower number of primers and is based on short primers with generally lower synthesis and purification costs. To highlight our approach, we pooled over 900 different small-subunit rRNA and functional gene amplicon libraries obtained from various environmental or host-associated microbial community samples into a single, paired-end Illumina MiSeq run. Although the amplicon regions ranged in size from approximately 290 to 720 bp, we found no significant systematic sequencing bias related to amplicon length or gene target. Our results indicate that this flexible multiplexing approach produces large, diverse, and high quality sets of amplicon sequence data for modern studies in microbial ecology. PMID:26236305

A modular, programmable measurement system for physiological and spaceflight applications

NASA Technical Reports Server (NTRS)

Hines, John W.; Ricks, Robert D.; Miles, Christopher J.

1993-01-01

The NASA-Ames Sensors 2000! Program has developed a small, compact, modular, programmable, sensor signal conditioning and measurement system, initially targeted for Life Sciences Spaceflight Programs. The system consists of a twelve-slot, multi-layer, distributed function backplane, a digital microcontroller/memory subsystem, conditioned and isolated power supplies, and six application-specific, physiological signal conditioners. Each signal condition is capable of being programmed for gains, offsets, calibration and operate modes, and, in some cases, selectable outputs and functional modes. Presently, the system has the capability for measuring ECG, EMG, EEG, Temperature, Respiration, Pressure, Force, and Acceleration parameters, in physiological ranges. The measurement system makes heavy use of surface-mount packaging technology, resulting in plug in modules sized 125x55 mm. The complete 12-slot system is contained within a volume of 220x150x70mm. The system's capabilities extend well beyond the specific objectives of NASA programs. Indeed, the potential commercial uses of the technology are virtually limitless. In addition to applications in medical and biomedical sensing, the system might also be used in process control situations, in clinical or research environments, in general instrumentation systems, factory processing, or any other applications where high quality measurements are required.

A modular, programmable measurement system for physiological and spaceflight applications

NASA Astrophysics Data System (ADS)

Hines, John W.; Ricks, Robert D.; Miles, Christopher J.

1993-02-01

The NASA-Ames Sensors 2000] Program has developed a small, compact, modular, programmable, sensor signal conditioning and measurement system, initially targeted for Life Sciences Spaceflight Programs. The system consists of a twelve-slot, multi-layer, distributed function backplane, a digital microcontroller/memory subsystem, conditioned and isolated power supplies, and six application-specific, physiological signal conditioners. Each signal condition is capable of being programmed for gains, offsets, calibration and operate modes, and, in some cases, selectable outputs and functional modes. Presently, the system has the capability for measuring ECG, EMG, EEG, Temperature, Respiration, Pressure, Force, and Acceleration parameters, in physiological ranges. The measurement system makes heavy use of surface-mount packaging technology, resulting in plug in modules sized 125x55 mm. The complete 12-slot system is contained within a volume of 220x150x70mm. The system's capabilities extend well beyond the specific objectives of NASA programs. Indeed, the potential commercial uses of the technology are virtually limitless. In addition to applications in medical and biomedical sensing, the system might also be used in process control situations, in clinical or research environments, in general instrumentation systems, factory processing, or any other applications where high quality measurements are required.

Is Internet Pornography Causing Sexual Dysfunctions? A Review with Clinical Reports.

PubMed

Park, Brian Y; Wilson, Gary; Berger, Jonathan; Christman, Matthew; Reina, Bryn; Bishop, Frank; Klam, Warren P; Doan, Andrew P

2016-08-05

Traditional factors that once explained men's sexual difficulties appear insufficient to account for the sharp rise in erectile dysfunction, delayed ejaculation, decreased sexual satisfaction, and diminished libido during partnered sex in men under 40. This review (1) considers data from multiple domains, e.g., clinical, biological (addiction/urology), psychological (sexual conditioning), sociological; and (2) presents a series of clinical reports, all with the aim of proposing a possible direction for future research of this phenomenon. Alterations to the brain's motivational system are explored as a possible etiology underlying pornography-related sexual dysfunctions. This review also considers evidence that Internet pornography's unique properties (limitless novelty, potential for easy escalation to more extreme material, video format, etc.) may be potent enough to condition sexual arousal to aspects of Internet pornography use that do not readily transition to real-life partners, such that sex with desired partners may not register as meeting expectations and arousal declines. Clinical reports suggest that terminating Internet pornography use is sometimes sufficient to reverse negative effects, underscoring the need for extensive investigation using methodologies that have subjects remove the variable of Internet pornography use. In the interim, a simple diagnostic protocol for assessing patients with porn-induced sexual dysfunction is put forth.

Induced Pluripotent Stem Cells: A novel frontier in the study of human primary immunodeficiencies

PubMed Central

Pessach, Itai M.; Ordovas-Montanes, Jose; Zhang, Shen-Ying; Casanova, Jean-Laurent; Giliani, Silvia; Gennery, Andrew R.; Al-Herz, Waleed; Manos, Philip D.; Schlaeger, Thorsten M.; Park, In-Hyun; Rucci, Francesca; Agarwal, Suneet; Mostoslavsky, Gustavo; Daley, George Q.; Notarangelo, Luigi D.

2010-01-01

Background The novel ability to epigenetically reprogram somatic cells into induced pluripotent stem cells through the exogenous expression of transcription promises to revolutionize the study of human diseases. Objective Here we report on the generation of 25 induced pluripotent stem cell lines from 6 patients with various forms of Primary Immunodeficiencies, affecting adaptive and/or innate immunity. Methods Patients’ dermal fibroblasts were reprogrammed by expression of four transcription factors, OCT4, SOX2, KLF4, and c-MYC using a single excisable polycistronic lentiviral vector. Results Induced pluripotent stem cells derived from patients with primary immunodeficiencies show a stemness profile that is comparable to that observed in human embryonic stem cells. Following in vitro differentiation into embryoid bodies, pluripotency of the patient-derived indiced pluripotent stem cells lines was demonstrated by expression of genes characteristic of each of the three embryonic layers. We have confirmed the patient-specific origin of the induced pluripotent stem cell lines, and ascertained maintenance of karyotypic integrity. Conclusion By providing a limitless source of diseased stem cells that can be differentiated into various cell types in vitro, the repository of induced pluripotent stem cell lines from patients with primary immunodeficiencies represents a unique resource to investigate the pathophysiology of hematopoietic and extra-hematopoietic manifestations of these diseases, and may assist in the development of novel therapeutic approaches based on gene correction. PMID:21185069

JobCenter: an open source, cross-platform, and distributed job queue management system optimized for scalability and versatility

PubMed Central

2012-01-01

Background Laboratories engaged in computational biology or bioinformatics frequently need to run lengthy, multistep, and user-driven computational jobs. Each job can tie up a computer for a few minutes to several days, and many laboratories lack the expertise or resources to build and maintain a dedicated computer cluster. Results JobCenter is a client–server application and framework for job management and distributed job execution. The client and server components are both written in Java and are cross-platform and relatively easy to install. All communication with the server is client-driven, which allows worker nodes to run anywhere (even behind external firewalls or “in the cloud”) and provides inherent load balancing. Adding a worker node to the worker pool is as simple as dropping the JobCenter client files onto any computer and performing basic configuration, which provides tremendous ease-of-use, flexibility, and limitless horizontal scalability. Each worker installation may be independently configured, including the types of jobs it is able to run. Executed jobs may be written in any language and may include multistep workflows. Conclusions JobCenter is a versatile and scalable distributed job management system that allows laboratories to very efficiently distribute all computational work among available resources. JobCenter is freely available at http://code.google.com/p/jobcenter/. PMID:22846423

Uranium Adsorbent Fibers Prepared by Atom-Transfer Radical Polymerization from Chlorinated Polypropylene and Polyethylene Trunk Fibers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, Suree; Chatterjee, Sabornie; Li, Meijun

Seawater contains a large amount of uranium (~4.5 billion tons) which can serve as a limitless supply of an energy source. However, in order to make the recovery of uranium from seawater economically feasible, lower manufacturing and deployment costs are required, and thus, solid adsorbents must have high uranium uptake, reusability, and high selectivity toward uranium. In this study, atom-transfer radical polymerization (ATRP), without the radiation-induced graft polymerization (RIGP), was used for grafting acrylonitrile (AN) and tert-butyl acrylate (tBA) from a new class of trunk fibers, forming adsorbents in a readily deployable form. The new class of trunk fibers wasmore » prepared by the chlorination of PP round fiber, hollow-gear-shaped PP fiber, and hollow-gear-shaped PE fiber. During ATRP, degrees of grafting (d.g.) varied according to the structure of active chlorine sites on trunk fibers and ATRP conditions, and the d.g. as high as 2570% was obtained. Resulting adsorbent fibers were evaluated in U-spiked simulated seawater and the maximum adsorption capacity of 146.6 g U/kg, much higher than that of a standard adsorbent JAEA fiber (75.1 g/kg), was obtained. This new type of trunk fibers can be used for grafting a variety of uranium-interacting ligands, including designed ligands that are highly selective toward uranium.« less

Uranium Adsorbent Fibers Prepared by Atom-Transfer Radical Polymerization from Chlorinated Polypropylene and Polyethylene Trunk Fibers

DOE PAGES

Brown, Suree; Chatterjee, Sabornie; Li, Meijun; ...

2015-12-10

Seawater contains a large amount of uranium (~4.5 billion tons) which can serve as a limitless supply of an energy source. However, in order to make the recovery of uranium from seawater economically feasible, lower manufacturing and deployment costs are required, and thus, solid adsorbents must have high uranium uptake, reusability, and high selectivity toward uranium. In this study, atom-transfer radical polymerization (ATRP), without the radiation-induced graft polymerization (RIGP), was used for grafting acrylonitrile (AN) and tert-butyl acrylate (tBA) from a new class of trunk fibers, forming adsorbents in a readily deployable form. The new class of trunk fibers wasmore » prepared by the chlorination of PP round fiber, hollow-gear-shaped PP fiber, and hollow-gear-shaped PE fiber. During ATRP, degrees of grafting (d.g.) varied according to the structure of active chlorine sites on trunk fibers and ATRP conditions, and the d.g. as high as 2570% was obtained. Resulting adsorbent fibers were evaluated in U-spiked simulated seawater and the maximum adsorption capacity of 146.6 g U/kg, much higher than that of a standard adsorbent JAEA fiber (75.1 g/kg), was obtained. This new type of trunk fibers can be used for grafting a variety of uranium-interacting ligands, including designed ligands that are highly selective toward uranium.« less

Current and emerging basic science concepts in bone biology: implications in craniofacial surgery.

PubMed

Oppenheimer, Adam J; Mesa, John; Buchman, Steven R

2012-01-01

Ongoing research in bone biology has brought cutting-edge technologies into everyday use in craniofacial surgery. Nonetheless, when osseous defects of the craniomaxillofacial skeleton are encountered, autogenous bone grafting remains the criterion standard for reconstruction. Accordingly, the core principles of bone graft physiology continue to be of paramount importance. Bone grafts, however, are not a panacea; donor site morbidity and operative risk are among the limitations of autologous bone graft harvest. Bone graft survival is impaired when irradiation, contamination, and impaired vascularity are encountered. Although the dura can induce calvarial ossification in children younger than 2 years, the repair of critical-size defects in the pediatric population may be hindered by inadequate bone graft donor volume. The novel and emerging field of bone tissue engineering holds great promise as a limitless source of autogenous bone. Three core constituents of bone tissue engineering have been established: scaffolds, signals, and cells. Blood supply is the sine qua non of these components, which are used both individually and concertedly in regenerative craniofacial surgery. The discerning craniofacial surgeon must determine the proper use for these bone graft alternatives, while understanding their concomitant risks. This article presents a review of contemporary and emerging concepts in bone biology and their implications in craniofacial surgery. Current practices, areas of controversy, and near-term future applications are emphasized.

The Community Intercomparison Suite (CIS)

NASA Astrophysics Data System (ADS)

Watson-Parris, Duncan; Schutgens, Nick; Cook, Nick; Kipling, Zak; Kershaw, Phil; Gryspeerdt, Ed; Lawrence, Bryan; Stier, Philip

2017-04-01

Earth observations (both remote and in-situ) create vast amounts of data providing invaluable constraints for the climate science community. Efficient exploitation of these complex and highly heterogeneous datasets has been limited however by the lack of suitable software tools, particularly for comparison of gridded and ungridded data, thus reducing scientific productivity. CIS (http://cistools.net) is an open-source, command line tool and Python library which allows the straight-forward quantitative analysis, intercomparison and visualisation of remote sensing, in-situ and model data. The CIS can read gridded and ungridded remote sensing, in-situ and model data - and many other data sources 'out-of-the-box', such as ESA Aerosol and Cloud CCI product, MODIS, Cloud CCI, Cloudsat, AERONET. Perhaps most importantly however CIS also employs a modular plugin architecture to allow for the reading of limitless different data types. Users are able to write their own plugins for reading the data sources which they are familiar with, and share them within the community, allowing all to benefit from their expertise. To enable the intercomparison of this data the CIS provides a number of operations including: the aggregation of ungridded and gridded datasets to coarser representations using a number of different built in averaging kernels; the subsetting of data to reduce its extent or dimensionality; the co-location of two distinct datasets onto a single set of co-ordinates; the visualisation of the input or output data through a number of different plots and graphs; the evaluation of arbitrary mathematical expressions against any number of datasets; and a number of other supporting functions such as a statistical comparison of two co-located datasets. These operations can be performed efficiently on local machines or large computing clusters - and is already available on the JASMIN computing facility. A case-study using the GASSP collection of in-situ aerosol observations will demonstrate the power of using CIS to perform model evaluations. The use of an open-source, community developed tool in this way opens up a huge amount of data which would previously have been inaccessible to many users, while also providing replicable, repeatable analysis which scientists and policy-makers alike can trust and understand.

State of the art: stem cells in equine regenerative medicine.

PubMed

Lopez, M J; Jarazo, J

2015-03-01

According to Greek mythology, Prometheus' liver grew back nightly after it was removed each day by an eagle as punishment for giving mankind fire. Hence, contrary to popular belief, the concept of tissue and organ regeneration is not new. In the early 20th century, cell culture and ex vivo organ preservation studies by Alexis Carrel, some with famed aviator Charles Lindbergh, established a foundation for much of modern regenerative medicine. While early beliefs and discoveries foreshadowed significant accomplishments in regenerative medicine, advances in knowledge within numerous scientific disciplines, as well as nano- and micromolecular level imaging and detection technologies, have contributed to explosive advances over the last 20 years. Virtually limitless preparations, combinations and applications of the 3 major components of regenerative medicine, namely cells, biomaterials and bioactive molecules, have created a new paradigm of future therapeutic options for most species. It is increasingly clear, however, that despite significant parallels among and within species, there is no 'one-size-fits-all' regenerative therapy. Likewise, a panacea has yet to be discovered that completely reverses the consequences of time, trauma and disease. Nonetheless, there is no question that the promise and potential of regenerative medicine have forever altered medical practices. The horse is a relative newcomer to regenerative medicine applications, yet there is already a large body of work to incorporate novel regenerative therapies into standard care. This review focuses on the current state and potential future of stem cells in equine regenerative medicine. © 2014 EVJ Ltd.

Modelling the evolution and diversity of cumulative culture

PubMed Central

Enquist, Magnus; Ghirlanda, Stefano; Eriksson, Kimmo

2011-01-01

Previous work on mathematical models of cultural evolution has mainly focused on the diffusion of simple cultural elements. However, a characteristic feature of human cultural evolution is the seemingly limitless appearance of new and increasingly complex cultural elements. Here, we develop a general modelling framework to study such cumulative processes, in which we assume that the appearance and disappearance of cultural elements are stochastic events that depend on the current state of culture. Five scenarios are explored: evolution of independent cultural elements, stepwise modification of elements, differentiation or combination of elements and systems of cultural elements. As one application of our framework, we study the evolution of cultural diversity (in time as well as between groups). PMID:21199845

Paranormal health claims.

PubMed

Skrabanek, P

1988-04-15

Faith in paranormal cures has always been the last hope of many sufferers from chronic or incurable diseases. Magico-religious rituals of healing are still around, but some have been replaced by pseudo-scientific systems, thinly disguising old superstitions in new obscurantism, more appealing to the half-educated. In medical quackery, inventiveness seems to be limitless, and only the main paranormal healing systems can be reviewed here. The increasing popularity of 'alternative' healing indicates the extent of dissatisfaction with dehumanising aspects of modern, technological medicine and its preoccupation with curing the curable at the expense of caring for the incurable. This leaves the sufferers, and also healthy people labelled with non-existent diseases, bleeding prey for the sharks roving the seas of medical ignorance.

Signaling Interplay between Bone Marrow Adipose Tissue and Multiple Myeloma cells.

PubMed

Falank, Carolyne; Fairfield, Heather; Reagan, Michaela R

2016-01-01

In the year 2000, Hanahan and Weinberg (1) defined the six Hallmarks of Cancer as: self-sufficiency in growth signals, evasion of apoptosis, insensitivity to antigrowth mechanisms, tissue invasion and metastasis, limitless replicative potential, and sustained angiogenesis. Eleven years later, two new Hallmarks were added to the list (avoiding immune destruction and reprograming energy metabolism) and two new tumor characteristics (tumor-promoting inflammation and genome instability and mutation) (2). In multiple myeloma (MM), a destructive cancer of the plasma cell that grows predominantly in the bone marrow (BM), it is clear that all these hallmarks and characteristics are in play, contributing to tumor initiation, drug resistance, disease progression, and relapse. Bone marrow adipose tissue (BMAT) is a newly recognized contributor to MM oncogenesis and disease progression, potentially affecting MM cell metabolism, immune action, inflammation, and influences on angiogenesis. In this review, we discuss the confirmed and hypothetical contributions of BMAT to MM development and disease progression. BMAT has been understudied due to technical challenges and a previous lack of appreciation for the endocrine function of this tissue. In this review, we define the dynamic, responsive, metabolically active BM adipocyte. We then describe how BMAT influences MM in terms of: lipids/metabolism, hypoxia/angiogenesis, paracrine or endocrine signaling, and bone disease. We then discuss the connection between BMAT and systemic inflammation and potential treatments to inhibit the feedback loops between BM adipocytes and MM cells that support MM progression. We aim for researchers to use this review to guide and help prioritize their experiments to develop better treatments or a cure for cancers, such as MM, that associate with and may depend on BMAT.

Signaling Interplay between Bone Marrow Adipose Tissue and Multiple Myeloma cells

PubMed Central

Falank, Carolyne; Fairfield, Heather; Reagan, Michaela R.

2016-01-01

In the year 2000, Hanahan and Weinberg (1) defined the six Hallmarks of Cancer as: self-sufficiency in growth signals, evasion of apoptosis, insensitivity to antigrowth mechanisms, tissue invasion and metastasis, limitless replicative potential, and sustained angiogenesis. Eleven years later, two new Hallmarks were added to the list (avoiding immune destruction and reprograming energy metabolism) and two new tumor characteristics (tumor-promoting inflammation and genome instability and mutation) (2). In multiple myeloma (MM), a destructive cancer of the plasma cell that grows predominantly in the bone marrow (BM), it is clear that all these hallmarks and characteristics are in play, contributing to tumor initiation, drug resistance, disease progression, and relapse. Bone marrow adipose tissue (BMAT) is a newly recognized contributor to MM oncogenesis and disease progression, potentially affecting MM cell metabolism, immune action, inflammation, and influences on angiogenesis. In this review, we discuss the confirmed and hypothetical contributions of BMAT to MM development and disease progression. BMAT has been understudied due to technical challenges and a previous lack of appreciation for the endocrine function of this tissue. In this review, we define the dynamic, responsive, metabolically active BM adipocyte. We then describe how BMAT influences MM in terms of: lipids/metabolism, hypoxia/angiogenesis, paracrine or endocrine signaling, and bone disease. We then discuss the connection between BMAT and systemic inflammation and potential treatments to inhibit the feedback loops between BM adipocytes and MM cells that support MM progression. We aim for researchers to use this review to guide and help prioritize their experiments to develop better treatments or a cure for cancers, such as MM, that associate with and may depend on BMAT. PMID:27379019

Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell

PubMed Central

Sotiropoulou, Georgia; Pampalakis, Georgios; Lianidou, Evi; Mourelatos, Zissimos

2009-01-01

Transformation of normal cells into malignant tumors requires the acquisition of six hallmark traits, e.g., self-sufficiency in growth signals, insensitivity to antigrowth signals and self-renewal, evasion of apoptosis, limitless replication potential, angiogenesis, invasion, and metastasis, which are common to all cancers (Hanahan and Weinberg 2000). These new cellular traits evolve from defects in major regulatory microcircuits that are fundamental for normal homeostasis. The discovery of microRNAs (miRNAs) as a new class of small non-protein-coding RNAs that control gene expression post-transcriptionally by binding to various mRNA targets suggests that these tiny RNA molecules likely act as molecular switches in the extensive regulatory web that involves thousands of transcripts. Most importantly, accumulating evidence suggests that numerous microRNAs are aberrantly expressed in human cancers. In this review, we discuss the emergent roles of microRNAs as switches that function to turn on/off known cellular microcircuits. We outline recent compelling evidence that deregulated microRNA-mediated control of cellular microcircuits cooperates with other well-established regulatory mechanisms to confer the hallmark traits of the cancer cell. Furthermore, these exciting insights into aberrant microRNA control in cancer-associated circuits may be exploited for cancer therapies that will target deregulated miRNA switches. PMID:19561119

Medical student appraisal: applications for bedside patient education.

PubMed

Markman, T M; Sampognaro, P J; Mitchell, S L; Weeks, S R; Khalifian, S; Dattilo, J R

2013-01-01

Medical students are often afforded the privilege of counselling patients. In the past resources were limited to pen and paper or anatomic models. The evolution of mobile applications allows for limitless access to resources that facilitate bedside patient education. To evaluate the utility of six applications in patient education and promote awareness of implementing mobile resources in clinical care. Six medical students rotating on various clerkships evaluated a total of six mobile applications. Strengths, limitations, and suggested uses in clinical care were identified. Applications included Meditoons™, VisiblePatient™, DrawMD™, CardioTeach™, Visual Anatomy™, and 360° Patient Education Suite™. Data was generated from narrative responses supplied by each student during their evaluation period. Bedside teaching was enhanced by professional illustrations and animations depicting anatomy and pathophysiology. Impromptu teaching was facilitated, as resources were conveniently available on a student's smartphone or tablet. The ability to annotate and modify images and subsequently email to patients was an extraordinary improvement in provider-patient communication. Universal limitations included small smartphone screens and the novelty of new technology. Mobile applications have the potential to greatly enhance patient education and simultaneously build rapport. Endless opportunities exist for their integration in clinical practice, particularly for new diagnoses, consent for procedures, and at time of discharge. Providers should be encouraged to try new applications and utilize them with patients.

The triple helix--NIH, industry, and the academic world.

PubMed Central

Lowe, C. U.

1982-01-01

Spectacular accomplishments in biomedical research have given birth to what is now perceived as a biological revolution, an epoch in which man has acquired the skill to manipulate the fundamental unit of heredity, the gene. This revolution carries with it the prospect of remarkable opportunities to improve the quality of life and to probe with increasing precision the mysteries of cellular organization and function. It comes, however, at a time when the opportunity to exploit this new knowledge may be limited by a significant reduction in federal support of basic research, and a situation which prompts universities and other centers of scientific activity to seek funding from industrial patrons. This trend has generated a new constellation of institutional challenges, for one apparent result of industrial sponsorship of university-based biomedical research is a threat to university governance as altered allegiances emerge and as the potential for financial gain appears almost limitless. This essay explores background issues leading to these new alliances, seeks to identify some of the central problems emerging for university administrators, faculty, and students, and then poses a key question: Can industrial support for university-based biomedical research fill the apparent short-fall in federal dollars in the foreseeable future? An analysis of available data indicates that this outcome is unlikely either now or in the years ahead. PMID:7180024

Towards establishing compact imaging spectrometer standards

USGS Publications Warehouse

Slonecker, E. Terrence; Allen, David W.; Resmini, Ronald G.

2016-01-01

Remote sensing science is currently undergoing a tremendous expansion in the area of hyperspectral imaging (HSI) technology. Spurred largely by the explosive growth of Unmanned Aerial Vehicles (UAV), sometimes called Unmanned Aircraft Systems (UAS), or drones, HSI capabilities that once required access to one of only a handful of very specialized and expensive sensor systems are now miniaturized and widely available commercially. Small compact imaging spectrometers (CIS) now on the market offer a number of hyperspectral imaging capabilities in terms of spectral range and sampling. The potential uses of HSI/CIS on UAVs/UASs seem limitless. However, the rapid expansion of unmanned aircraft and small hyperspectral sensor capabilities has created a number of questions related to technological, legal, and operational capabilities. Lightweight sensor systems suitable for UAV platforms are being advertised in the trade literature at an ever-expanding rate with no standardization of system performance specifications or terms of reference. To address this issue, both the U.S. Geological Survey and the National Institute of Standards and Technology are eveloping draft standards to meet these issues. This paper presents the outline of a combined USGS/NIST cooperative strategy to develop and test a characterization methodology to meet the needs of a new and expanding UAV/CIS/HSI user community.

Computer-Aided Design of RNA Origami Structures.

PubMed

Sparvath, Steffen L; Geary, Cody W; Andersen, Ebbe S

2017-01-01

RNA nanostructures can be used as scaffolds to organize, combine, and control molecular functionalities, with great potential for applications in nanomedicine and synthetic biology. The single-stranded RNA origami method allows RNA nanostructures to be folded as they are transcribed by the RNA polymerase. RNA origami structures provide a stable framework that can be decorated with functional RNA elements such as riboswitches, ribozymes, interaction sites, and aptamers for binding small molecules or protein targets. The rich library of RNA structural and functional elements combined with the possibility to attach proteins through aptamer-based binding creates virtually limitless possibilities for constructing advanced RNA-based nanodevices.In this chapter we provide a detailed protocol for the single-stranded RNA origami design method using a simple 2-helix tall structure as an example. The first step involves 3D modeling of a double-crossover between two RNA double helices, followed by decoration with tertiary motifs. The second step deals with the construction of a 2D blueprint describing the secondary structure and sequence constraints that serves as the input for computer programs. In the third step, computer programs are used to design RNA sequences that are compatible with the structure, and the resulting outputs are evaluated and converted into DNA sequences to order.

Is Internet Pornography Causing Sexual Dysfunctions? A Review with Clinical Reports

PubMed Central

Park, Brian Y.; Wilson, Gary; Berger, Jonathan; Christman, Matthew; Reina, Bryn; Bishop, Frank; Klam, Warren P.; Doan, Andrew P.

2016-01-01

Traditional factors that once explained men’s sexual difficulties appear insufficient to account for the sharp rise in erectile dysfunction, delayed ejaculation, decreased sexual satisfaction, and diminished libido during partnered sex in men under 40. This review (1) considers data from multiple domains, e.g., clinical, biological (addiction/urology), psychological (sexual conditioning), sociological; and (2) presents a series of clinical reports, all with the aim of proposing a possible direction for future research of this phenomenon. Alterations to the brain's motivational system are explored as a possible etiology underlying pornography-related sexual dysfunctions. This review also considers evidence that Internet pornography’s unique properties (limitless novelty, potential for easy escalation to more extreme material, video format, etc.) may be potent enough to condition sexual arousal to aspects of Internet pornography use that do not readily transition to real-life partners, such that sex with desired partners may not register as meeting expectations and arousal declines. Clinical reports suggest that terminating Internet pornography use is sometimes sufficient to reverse negative effects, underscoring the need for extensive investigation using methodologies that have subjects remove the variable of Internet pornography use. In the interim, a simple diagnostic protocol for assessing patients with porn-induced sexual dysfunction is put forth. PMID:27527226

Asteroid exploration and utilization: The Hawking explorer

NASA Technical Reports Server (NTRS)

Carlson, Alan; Date, Medha; Duarte, Manny; Erian, Neil; Gafka, George; Kappler, Peter; Patano, Scott; Perez, Martin; Ponce, Edgar; Radovich, Brian

1991-01-01

The Earth is nearing depletion of its natural resources at a time when human beings are rapidly expanding the frontiers of space. The resources which may exist on asteroids could have enormous potential for aiding and enhancing human space exploration as well as life on Earth. With the possibly limitless opportunities that exist, it is clear that asteroids are the next step for human existence in space. This report comprises the efforts of NEW WORLDS, Inc. to develop a comprehensive design for an asteroid exploration/sample return mission. This mission is a precursor to proof-of-concept missions that will investigate the validity of mining and materials processing on an asteroid. Project STONER (Systematic Transfer of Near Earth Resources) is based on two utilization scenarios: (1) moving an asteroid to an advantageous location for use by Earth; and (2) mining an asteroids and transporting raw materials back to Earth. The asteroid explorer/sample return mission is designed in the context of both scenarios and is the first phase of a long range plane for humans to utilize asteroid resources. The report concentrates specifically on the selection of the most promising asteroids for exploration and the development of an exploration scenario. Future utilization as well as subsystem requirements of an asteroid sample return probe are also addressed.

Asteroid exploration and utilization: The Hawking explorer

NASA Astrophysics Data System (ADS)

Carlson, Alan; Date, Medha; Duarte, Manny; Erian, Neil; Gafka, George; Kappler, Peter; Patano, Scott; Perez, Martin; Ponce, Edgar; Radovich, Brian

1991-12-01

The Earth is nearing depletion of its natural resources at a time when human beings are rapidly expanding the frontiers of space. The resources which may exist on asteroids could have enormous potential for aiding and enhancing human space exploration as well as life on Earth. With the possibly limitless opportunities that exist, it is clear that asteroids are the next step for human existence in space. This report comprises the efforts of NEW WORLDS, Inc. to develop a comprehensive design for an asteroid exploration/sample return mission. This mission is a precursor to proof-of-concept missions that will investigate the validity of mining and materials processing on an asteroid. Project STONER (Systematic Transfer of Near Earth Resources) is based on two utilization scenarios: (1) moving an asteroid to an advantageous location for use by Earth; and (2) mining an asteroids and transporting raw materials back to Earth. The asteroid explorer/sample return mission is designed in the context of both scenarios and is the first phase of a long range plane for humans to utilize asteroid resources. The report concentrates specifically on the selection of the most promising asteroids for exploration and the development of an exploration scenario. Future utilization as well as subsystem requirements of an asteroid sample return probe are also addressed.

Government/Industry Workshop on Payload Loads Technology

NASA Technical Reports Server (NTRS)

1978-01-01

A fully operational space shuttle is discussed which will offer science the opportunity to explore near earth orbit and finally interplanetary space on nearly a limitless basis. This multiplicity of payload/experiment combinations and frequency of launches places many burdens on dynamicists to predict launch and landing environments accurately and efficiently. Two major problems are apparent in the attempt to design for the diverse environments: (1) balancing the design criteria (loads, etc.) between launch and orbit operations, and (2) developing analytical techniques that are reliable, accurate, efficient, and low cost to meet the challenge of multiple launches and payloads. This paper deals with the key issues inherent in these problems, the key trades required, the basic approaches needed, and a summary of the state-of-the-art techniques.

A psychodynamic perspective on elections.

PubMed

Clemens, Norman A

2010-11-01

In a democracy, elections are the way in which the collective thought processes of the voters arrive at a decision to direct their government. The author explores how the individual voter assesses and resolves many conflicting internal and external forces to arrive at a vote. The midterm elections of 2010 illustrate the parallel between individual resolution of conflicting forces and the process of a campaign leading to the outcome of an election. The psychodynamic concepts of conflict and compromise, affects, aggression, unconscious forces, mechanisms of defense, superego, and the ego's integrative functions are evident in both the individual voter and the collective electoral process. The author expresses concern about the historical vulnerability of democracies and the unbalancing effect of allowing limitless infusion of anonymous corporate money to pour into campaigns.

Time and the psychiatric interview: the negotiation of temporal criteria of the depressive disorder.

PubMed

Ziólkowska, Justyna

2014-03-01

In this article, I am concerned with doctors' negotiations of the temporal dimension of the diagnostic criteria of depressive disorders during the first psychiatric interview. The data come from 16 initial psychiatric interviews recorded by doctors in three psychiatric hospitals in Poland. Taking a constructionist view of discourse and psychiatric practices, I shall argue that the discursive practice related to temporal information about patients' illnesses serves in gaining information, which is useful in the medical model of psychiatric diagnosis. The doctors positioned the patients' experiences on the timeline when the illness history was taken and temporal information authenticated the information. Conversely, the patients' current conditions were constructed in a limitless present, which allowed the psychiatrists to remove the relativity.

Map projections

USGS Publications Warehouse

,

1993-01-01

A map projection is used to portray all or part of the round Earth on a flat surface. This cannot be done without some distortion. Every projection has its own set of advantages and disadvantages. There is no "best" projection. The mapmaker must select the one best suited to the needs, reducing distortion of the most important features. Mapmakers and mathematicians have devised almost limitless ways to project the image of the globe onto paper. Scientists at the U. S. Geological Survey have designed projections for their specific needs—such as the Space Oblique Mercator, which allows mapping from satellites with little or no distortion. This document gives the key properties, characteristics, and preferred uses of many historically important projections and of those frequently used by mapmakers today.

A Comprehensive Plan for Global Energy Revolution

NASA Astrophysics Data System (ADS)

Blees, T.

2009-05-01

There is no dearth of information regarding the grave crises faced by humanity in the 21st century. There is also growing consensus that the wholesale burning of fossil fuels must come to an end, either because of climate change or other still-salient reasons such as air pollution or major conflicts over dwindling reserves of cheaply recoverable oil and gas resources. At the same time, global demographics predict with disquieting certainty a world with up to 9 or 10 billion souls by mid-century. The vast expansion of energy consumption that this population represents, along with further increases in already-unacceptable levels of atmospheric carbon dioxide from fossil fuel burning, demands that we quickly develop almost limitless sources of clean, economical power. What is sorely lacking in the public debate are realistic solutions. Expanding wind and solar generating capacity is an important near-term goal, but neither of these technologies represents a viable solution for generating base load power at the vast scales that will be required. Energy efficiency measures are likewise well-directed, but the combination of rising population along with increasingly energy-intensive economic activity by the large fraction of Earth's current population residing in developing nations suggests that absolute energy demand will continue to rise even with radically improved energy efficiency. Fortunately we have the technologies available to provide virtually unlimited clean energy, and to utilize and recycle our resources so that everyone can improve their standard of living. The Integral Fast Reactor (IFR), developed at the Argonne National Laboratory in the 80's and 90's and currently championed by General Electric, is a technology that fills the bill on every count, and then some. IFRs are safe, environmentally clean, economical, and free of conflict over fuel supply. IFRs can safely consume as fuel the nuclear waste from the current installed base of light-water reactors, as well as utilize the world's prodigious stockpiles of depleted uranium to supply all of humanity's energy needs for hundreds of years. Not only will IFR operations produce no greenhouse gas emissions, but even their construction will create several times less emissions per megawatt than wind and solar projects. Commercial development of zero-emission energy carriers for vehicle transport (such as hydrogen or boron) can assure that we efficiently translate IFR- generated power to our transportation infrastructure while eliminating the choking pollution of the world's ever- expanding vehicle fleet. If we make the decisions that must be made to deploy these new technologies, we stand at the threshhold of a post-scarcity era even as the starkness of our population dilemma would seem to indicate the opposite. Here is the blueprint for that new era, a comprehensive plan to provide limitless clean energy that can be implemented at less expense than taking a business-as-usual approach.

Elucidation of the Strongest Predictors of Cardiovascular Events in Patients with Heart Failure.

PubMed

Fukuda, Hiroki; Shindo, Kazuhiro; Sakamoto, Mari; Ide, Tomomi; Kinugawa, Shintaro; Fukushima, Arata; Tsutsui, Hiroyuki; Ito, Shin; Ishii, Akira; Washio, Takashi; Kitakaze, Masafumi

2018-06-20

In previous retrospective studies, we identified the 50 most influential clinical predictors of cardiovascular outcomes in patients with heart failure (HF). The present study aimed to use the novel limitless-arity multiple-testing procedure to filter these 50 clinical factors and thus yield combinations of no more than four factors that could potentially predict the onset of cardiovascular events. A Kaplan-Meier analysis was used to investigate the importance of the combinations. In a multi-centre observational trial, we prospectively enrolled 213 patients with HF who were hospitalized because of exacerbation, discharged according to HF treatment guidelines and observed to monitor cardiovascular events. After the observation period, we stratified patients according to whether they experienced cardiovascular events (rehospitalisation or cardiovascular death). Among 77,562 combinations of fewer than five clinical parameters, we identified 151 combinations that could potentially explain the occurrence of cardiovascular events. Of these, 145 combinations included the use of inotropic agents, whereas the remaining 6 included the use of diuretics without bradycardia or tachycardia, suggesting that the high probability of cardiovascular events is exclusively determined by these two clinical factors. Importantly, Kaplan-Meier curves demonstrated that the use of inotropes or of diuretics without bradycardia or tachycardia were independent predictors of a markedly worse cardiovascular prognosis. Patients treated with either inotropic agents or diuretics without bradycardia or tachycardia were at a higher risk of cardiovascular events. The uses of these drugs, regardless of heart rate, are the strongest clinical predictors of cardiovascular events in patients with HF. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

FUSION ENERGY SCIENCES WORKSHOP ON PLASMA MATERIALS INTERACTIONS: Report on Science Challenges and Research Opportunities in Plasma Materials Interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maingi, Rajesh; Zinkle, Steven J.; Foster, Mark S.

2015-05-01

The realization of controlled thermonuclear fusion as an energy source would transform society, providing a nearly limitless energy source with renewable fuel. Under the auspices of the U.S. Department of Energy, the Fusion Energy Sciences (FES) program management recently launched a series of technical workshops to “seek community engagement and input for future program planning activities” in the targeted areas of (1) Integrated Simulation for Magnetic Fusion Energy Sciences, (2) Control of Transients, (3) Plasma Science Frontiers, and (4) Plasma-Materials Interactions aka Plasma-Materials Interface (PMI). Over the past decade, a number of strategic planning activities1-6 have highlighted PMI and plasmamore » facing components as a major knowledge gap, which should be a priority for fusion research towards ITER and future demonstration fusion energy systems. There is a strong international consensus that new PMI solutions are required in order for fusion to advance beyond ITER. The goal of the 2015 PMI community workshop was to review recent innovations and improvements in understanding the challenging PMI issues, identify high-priority scientific challenges in PMI, and to discuss potential options to address those challenges. The community response to the PMI research assessment was enthusiastic, with over 80 participants involved in the open workshop held at Princeton Plasma Physics Laboratory on May 4-7, 2015. The workshop provided a useful forum for the scientific community to review progress in scientific understanding achieved during the past decade, and to openly discuss high-priority unresolved research questions. One of the key outcomes of the workshop was a focused set of community-initiated Priority Research Directions (PRDs) for PMI. Five PRDs were identified, labeled A-E, which represent community consensus on the most urgent near-term PMI scientific issues. For each PRD, an assessment was made of the scientific challenges, as well as a set of actions to address those challenges. No prioritization was attempted amongst these five PRDs. We note that ITER, an international collaborative project to substantially extend fusion science and technology, is implicitly a driver and beneficiary of the research described in these PRDs; specific ITER issues are discussed in the background and PRD chapters. For succinctness, we describe these PRDs directly below; a brief introduction to magnetic fusion and the workshop process/timeline is given in Chapter I, and panelists are listed in the Appendix.« less

Making Cloud Computing Available For Researchers and Innovators (Invited)

NASA Astrophysics Data System (ADS)

Winsor, R.

2010-12-01

High Performance Computing (HPC) facilities exist in most academic institutions but are almost invariably over-subscribed. Access is allocated based on academic merit, the only practical method of assigning valuable finite compute resources. Cloud computing on the other hand, and particularly commercial clouds, draw flexibly on an almost limitless resource as long as the user has sufficient funds to pay the bill. How can the commercial cloud model be applied to scientific computing? Is there a case to be made for a publicly available research cloud and how would it be structured? This talk will explore these themes and describe how Cybera, a not-for-profit non-governmental organization in Alberta Canada, aims to leverage its high speed research and education network to provide cloud computing facilities for a much wider user base.

Science on a Sphere and Data in the Classroom: A Marriage Between Limitless Learning Experiences.

NASA Astrophysics Data System (ADS)

Zepecki, S., III; Dean, A. F.; Pisut, D.

2017-12-01

NOAA and other agencies have contributed significantly to the creation and distribution of educational materials to enhance the public understanding of the interconnectedness of the Earth processes and human activities. Intended for two different learning audiences, Science on a Sphere and Data in the Classroom are both educational tools used to enhance understanding of our world and how human activity influences change. Recently, NOAA has undertaken the task of marrying Data in the Classroom's NGSS aligned curriculum, which includes topics such as El Niño, sea level rise, and coral bleaching, with Science on a Sphere's Earth and space data visualization exhibits. This partnership allows for the fluidity of NOAA's data-driven learning materials, and fosters the homogeneity of formal and informal learning experiences for varied audiences.

Over-the-counter topical skincare products: a review of the literature.

PubMed

Nolan, Katherine A; Marmur, Ellen S

2012-02-01

Topical "anti-aging" products, with their seemingly limitless list of ingredients, make extensive claims to reduce wrinkles, fine lines, and sun damage, among others. Sales in the United States alone for cosmeceutical products are expected to increase by 7.4% per year to $8.2 billion by 2012. However, in this enormous industry, there has been a significant lack of rigorous controlled trials of efficacy. It is difficult for both dermatologists and consumers to make informed decisions in a market that is yet to be clearly defined and regulated. We elucidate the scientific basis for, as well as the literature behind, common active ingredients found in products intended to reverse photoaging, discuss some interesting new activities, and provide a review of several comprehensive studies on over-the-counter (OTC) products.

Cytomics - importance of multimodal analysis of cell function and proliferation in oncology.

PubMed

Tárnok, A; Bocsi, J; Brockhoff, G

2006-12-01

Cancer is a highly complex and heterogeneous disease involving a succession of genetic changes (frequently caused or accompanied by exogenous trauma), and resulting in a molecular phenotype that in turn results in a malignant specification. The development of malignancy has been described as a multistep process involving self-sufficiency in growth signals, insensitivity to antigrowth signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis, and finally tissue invasion and metastasis. The quantitative analysis of networking molecules within the cells might be applied to understand native-state tissue signalling biology, complex drug actions and dysfunctional signalling in transformed cells, that is, in cancer cells. High-content and high-throughput single-cell analysis can lead to systems biology and cytomics. The application of cytomics in cancer research and diagnostics is very broad, ranging from the better understanding of the tumour cell biology to the identification of residual tumour cells after treatment, to drug discovery. The ultimate goal is to pinpoint in detail these processes on the molecular, cellular and tissue level. A comprehensive knowledge of these will require tissue analysis, which is multiplex and functional; thus, vast amounts of data are being collected from current genomic and proteomic platforms for integration and interpretation as well as for new varieties of updated cytomics technology. This overview will briefly highlight the most important aspects of this continuously developing field.

Quantum computing: a prime modality in neurosurgery's future.

PubMed

Lee, Brian; Liu, Charles Y; Apuzzo, Michael L J

2012-11-01

With each significant development in the field of neurosurgery, our dependence on computers, small and large, has continuously increased. From something as mundane as bipolar cautery to sophisticated intraoperative navigation with real-time magnetic resonance imaging-assisted surgical guidance, both technologies, however simple or complex, require computational processing power to function. The next frontier for neurosurgery involves developing a greater understanding of the brain and furthering our capabilities as surgeons to directly affect brain circuitry and function. This has come in the form of implantable devices that can electronically and nondestructively influence the cortex and nuclei with the purpose of restoring neuronal function and improving quality of life. We are now transitioning from devices that are turned on and left alone, such as vagus nerve stimulators and deep brain stimulators, to "smart" devices that can listen and react to the body as the situation may dictate. The development of quantum computers and their potential to be thousands, if not millions, of times faster than current "classical" computers, will significantly affect the neurosciences, especially the field of neurorehabilitation and neuromodulation. Quantum computers may advance our understanding of the neural code and, in turn, better develop and program implantable neural devices. When quantum computers reach the point where we can actually implant such devices in patients, the possibilities of what can be done to interface and restore neural function will be limitless. Copyright © 2012 Elsevier Inc. All rights reserved.

Surface Functionalized Nanostructured Ceramic Sorbents for the Effective Collection and Recovery of Uranium from Seawater

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chouyyok, Wilaiwan; Pittman, Jonathan W.; Warner, Marvin G.

2016-05-02

The ability to collect uranium from seawater offers the potential for a nearly limitless fuel supply for nuclear energy. We evaluated the use of functionalized nanostructured sorbents for the collection and recovery of uranium from seawater. Extraction of trace minerals from seawater and brines is challenging due to the high ionic strength of seawater, low mineral concentrations, and fouling of surfaces over time. We demonstrate that rationally assembled sorbent materials that integrate high affinity surface chemistry and high surface area nanostructures into an application relevant micro/macro structure enables collection performance that far exceeds typical sorbent materials. High surface area nanostructuredmore » silica with surface chemistries composed of phosphonic acid, phosphonates, 3,4 hydroxypyridinone, and EDTA showed superior performance for uranium collection. A few phosphorous-based commercial resins, specifically Diphonix and Ln Resin, also performed well. We demonstrate an effective and environmentally benign method of stripping the uranium from the high affinity sorbents using inexpensive nontoxic carbonate solutions. The cyclic use of preferred sorbents and acidic reconditioning of materials was shown to improve performance. Composite thin films composed of the nanostructured sorbents and a porous polymer binder are shown to have excellent kinetics and good capacity while providing an effective processing configuration for trace mineral recovery from solutions. Initial work using the composite thin films shows significant improvements in processing capacity over the previously reported sorbent materials.« less

Selectivity in Ligand Binding to Uranyl Compounds: A Synthetic, Structural, Thermodynamic and Computational Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arnold, John

The uranyl cation (UO 2 2+) is the most abundant form of uranium on the planet. It is estimated that 4.5 billion tons of uranium in this form exist in sea water. The ability to bind and extract the uranyl cation from aqueous solution while separating it from other elements would provide a limitless source of nuclear fuel. A large body of research concerns the selective recognition and extraction of uranyl. A stable molecule, the cation has a linear O=U=O geometry. The short U-O bonds (1.78 Å) arise from the combination of uranium 5f/6d and oxygen 2p orbitals. Due tomore » the oxygen moieties being multiply bonded, these sites were not thought to be basic enough for Lewis acidic coordination to be a viable approach to sequestration. We believe that the goal of developing a practical system for uranium separation from seawater will not be attained without new insights into our existing fundamental knowledge of actinide chemistry. We posit that detailed studies of the kinetic and thermodynamic factors that influence interactions between f-elements and ligands with a range of donor atoms is essential to any major advance in this important area. The goal of this research is thus to broaden the coordination chemistry of the uranyl ion by studying new ligand systems via synthetic, structural, thermodynamic and computational methods. We anticipate that this fundamental science will find use beyond actinide separation technologies in areas such as nuclear waste remediation and nuclear materials.« less

A semantic web framework to integrate cancer omics data with biological knowledge.

PubMed

Holford, Matthew E; McCusker, James P; Cheung, Kei-Hoi; Krauthammer, Michael

2012-01-25

The RDF triple provides a simple linguistic means of describing limitless types of information. Triples can be flexibly combined into a unified data source we call a semantic model. Semantic models open new possibilities for the integration of variegated biological data. We use Semantic Web technology to explicate high throughput clinical data in the context of fundamental biological knowledge. We have extended Corvus, a data warehouse which provides a uniform interface to various forms of Omics data, by providing a SPARQL endpoint. With the querying and reasoning tools made possible by the Semantic Web, we were able to explore quantitative semantic models retrieved from Corvus in the light of systematic biological knowledge. For this paper, we merged semantic models containing genomic, transcriptomic and epigenomic data from melanoma samples with two semantic models of functional data - one containing Gene Ontology (GO) data, the other, regulatory networks constructed from transcription factor binding information. These two semantic models were created in an ad hoc manner but support a common interface for integration with the quantitative semantic models. Such combined semantic models allow us to pose significant translational medicine questions. Here, we study the interplay between a cell's molecular state and its response to anti-cancer therapy by exploring the resistance of cancer cells to Decitabine, a demethylating agent. We were able to generate a testable hypothesis to explain how Decitabine fights cancer - namely, that it targets apoptosis-related gene promoters predominantly in Decitabine-sensitive cell lines, thus conveying its cytotoxic effect by activating the apoptosis pathway. Our research provides a framework whereby similar hypotheses can be developed easily.

Cell cycle control in acute myeloid leukemia

PubMed Central

Schnerch, Dominik; Yalcintepe, Jasmin; Schmidts, Andrea; Becker, Heiko; Follo, Marie; Engelhardt, Monika; Wäsch, Ralph

2012-01-01

Acute myeloid leukemia (AML) is the result of a multistep transforming process of hematopoietic precursor cells (HPCs) which enables them to proceed through limitless numbers of cell cycles and to become resistant to cell death. Increased proliferation renders these cells vulnerable to acquiring mutations and may favor leukemic transformation. Here, we review how deregulated cell cycle control contributes to increased proliferation in AML and favors genomic instability, a prerequisite to confer selective advantages to particular clones in order to adapt and independently proliferate in the presence of a changing microenvironment. We discuss the connection between differentiation and proliferation with regard to leukemogenesis and outline the impact of specific alterations on response to therapy. Finally, we present examples, how a better understanding of cell cycle regulation and deregulation has already led to new promising therapeutic strategies. PMID:22957304

Electronic Tongue—A Tool for All Tastes?

PubMed Central

Podrażka, Marta; Bączyńska, Ewa; Kundys, Magdalena; Jeleń, Paulina S.; Witkowska Nery, Emilia

2017-01-01

Electronic tongue systems are traditionally used to analyse: food products, water samples and taste masking technologies for pharmaceuticals. In principle, their applications are almost limitless, as they are able to almost completely reduce the impact of interferents and can be applied to distinguish samples of extreme complexity as for example broths from different stages of fermentation. Nevertheless, their applications outside the three principal sample types are, in comparison, rather scarce. In this review, we would like to take a closer look on what are real capabilities of electronic tongue systems, what can be achieved using mixed sensor arrays and by introduction of biosensors or molecularly imprinted polymers in the matrix. We will discuss future directions both in the sense of applications as well as system development in the ever-growing trend of low cost analysis. PMID:29301230

The study of non-fouling and non-specific cellular binding on functionalized surface for mammalian cell identification and manipulation

NASA Astrophysics Data System (ADS)

Zainudin, Nor Syuhada; Hambali, Nor Azura Malini Ahmad; Wahid, Mohamad Halim Abd; Retnasamy, Vithyacharan; Shahimin, Mukhzeer Mohamad

2017-04-01

Surface functionalization has emerged as a powerful tool for mapping limitless surface-cell membrane interaction in diverse biomolecular applications. Inhibition of non-specific biomolecular and cellular adhesion to solid surfaces is critical in improving the performance of some biomedical devices, particularly for in vitro bioassays. Some factors have to be paid particular attention in determining the right surface modification which are the types of surface, the methods and chemical solution that being used during the experimentation and also tools for analyzing the results. Improved surface functionalization technologies that provide better non-fouling performance in conjunction with specific attachment chemistries are sought for these applications. Hence, this paper serves as a review for multiple surface treatment methods including PEG grafting, adsorptive chemistries, self-assembled monolayers (SAMs) and plasma treatments.

Design, Optimization and Application of Small Molecule Biosensor in Metabolic Engineering.

PubMed

Liu, Yang; Liu, Ye; Wang, Meng

2017-01-01

The development of synthetic biology and metabolic engineering has painted a great future for the bio-based economy, including fuels, chemicals, and drugs produced from renewable feedstocks. With the rapid advance of genome-scale modeling, pathway assembling and genome engineering/editing, our ability to design and generate microbial cell factories with various phenotype becomes almost limitless. However, our lack of ability to measure and exert precise control over metabolite concentration related phenotypes becomes a bottleneck in metabolic engineering. Genetically encoded small molecule biosensors, which provide the means to couple metabolite concentration to measurable or actionable outputs, are highly promising solutions to the bottleneck. Here we review recent advances in the design, optimization and application of small molecule biosensor in metabolic engineering, with particular focus on optimization strategies for transcription factor (TF) based biosensors.

How NIF Works

ScienceCinema

None

2017-12-09

The National Ignition Facility, located at Lawrence Livermore National Laboratory, is the world's largest laser system... 192 huge laser beams in a massive building, all focused down at the last moment at a 2 millimeter ball containing frozen hydrogen gas. The goal is to achieve fusion... getting more energy out than was used to create it. It's never been done before under controlled conditions, just in nuclear weapons and in stars. We expect to do it within the next 2-3 years. The purpose is threefold: to create an almost limitless supply of safe, carbon-free, proliferation-free electricity; examine new regimes of astrophysics as well as basic science; and study the inner-workings of the U.S. stockpile of nuclear weapons to ensure they remain safe, secure and reliable without the need for underground testing. More information about NIF can be found at:

Design, Optimization and Application of Small Molecule Biosensor in Metabolic Engineering

PubMed Central

Liu, Yang; Liu, Ye; Wang, Meng

2017-01-01

The development of synthetic biology and metabolic engineering has painted a great future for the bio-based economy, including fuels, chemicals, and drugs produced from renewable feedstocks. With the rapid advance of genome-scale modeling, pathway assembling and genome engineering/editing, our ability to design and generate microbial cell factories with various phenotype becomes almost limitless. However, our lack of ability to measure and exert precise control over metabolite concentration related phenotypes becomes a bottleneck in metabolic engineering. Genetically encoded small molecule biosensors, which provide the means to couple metabolite concentration to measurable or actionable outputs, are highly promising solutions to the bottleneck. Here we review recent advances in the design, optimization and application of small molecule biosensor in metabolic engineering, with particular focus on optimization strategies for transcription factor (TF) based biosensors. PMID:29089935

Gold Nanoparticles for Biology and Medicine

PubMed Central

Giljohann, David A.; Seferos, Dwight S.; Daniel, Weston L.; Massich, Matthew D.; Patel, Pinal C.

2014-01-01

Gold colloids have fascinated scientists for over a century and are now heavily utilized in chemistry, biology, engineering, and medicine. Today these materials can be synthesized reproducibly, modified with seemingly limitless chemical functional groups, and, in certain cases, characterized with atomic-level precision. This Review highlights recent advances in the synthesis, bioconjugation, and cellular uses of gold nanoconjugates. There are now many examples of highly sensitive and selective assays based upon gold nanoconjugates. In recent years, focus has turned to therapeutic possibilities for such materials. Structures which behave as gene-regulating agents, drug carriers, imaging agents, and photoresponsive therapeutics have been developed and studied in the context of cells and many debilitating diseases. These structures are not simply chosen as alternatives to molecule-based systems, but rather for their new physical and chemical properties, which confer substantive advantages in cellular and medical applications. PMID:20401880

Bone Tissue Engineering: Recent Advances and Challenges

PubMed Central

Amini, Ami R.; Laurencin, Cato T.; Nukavarapu, Syam P.

2013-01-01

The worldwide incidence of bone disorders and conditions has trended steeply upward and is expected to double by 2020, especially in populations where aging is coupled with increased obesity and poor physical activity. Engineered bone tissue has been viewed as a potential alternative to the conventional use of bone grafts, due to their limitless supply and no disease transmission. However, bone tissue engineering practices have not proceeded to clinical practice due to several limitations or challenges. Bone tissue engineering aims to induce new functional bone regeneration via the synergistic combination of biomaterials, cells, and factor therapy. In this review, we discuss the fundamentals of bone tissue engineering, highlighting the current state of this field. Further, we review the recent advances of biomaterial and cell-based research, as well as approaches used to enhance bone regeneration. Specifically, we discuss widely investigated biomaterial scaffolds, micro- and nano-structural properties of these scaffolds, and the incorporation of biomimetic properties and/or growth factors. In addition, we examine various cellular approaches, including the use of mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), adult stem cells, induced pluripotent stem cells (iPSCs), and platelet-rich plasma (PRP), and their clinical application strengths and limitations. We conclude by overviewing the challenges that face the bone tissue engineering field, such as the lack of sufficient vascularization at the defect site, and the research aimed at functional bone tissue engineering. These challenges will drive future research in the field. PMID:23339648

Thermoplastic processing of proteins for film formation--a review.

PubMed

Hernandez-Izquierdo, V M; Krochta, J M

2008-03-01

Increasing interest in high-quality food products with increased shelf life and reduced environmental impact has encouraged the study and development of edible and/or biodegradable polymer films and coatings. Edible films provide the opportunity to effectively control mass transfer among different components in a food or between the food and its surrounding environment. The diversity of proteins that results from an almost limitless number of side-chain amino-acid sequential arrangements allows for a wide range of interactions and chemical reactions to take place as proteins denature and cross-link during heat processing. Proteins such as wheat gluten, corn zein, soy protein, myofibrillar proteins, and whey proteins have been successfully formed into films using thermoplastic processes such as compression molding and extrusion. Thermoplastic processing can result in a highly efficient manufacturing method with commercial potential for large-scale production of edible films due to the low moisture levels, high temperatures, and short times used. Addition of water, glycerol, sorbitol, sucrose, and other plasticizers allows the proteins to undergo the glass transition and facilitates deformation and processability without thermal degradation. Target film variables, important in predicting biopackage performance under various conditions, include mechanical, thermal, barrier, and microstructural properties. Comparisons of film properties should be made with care since results depend on parameters such as film-forming materials, film formulation, fabrication method, operating conditions, testing equipment, and testing conditions. Film applications include their use as wraps, pouches, bags, casings, and sachets to protect foods, reduce waste, and improve package recyclability.

Limitless capacity: a dynamic object-oriented approach to short-term memory.

PubMed

Macken, Bill; Taylor, John; Jones, Dylan

2015-01-01

The notion of capacity-limited processing systems is a core element of cognitive accounts of limited and variable performance, enshrined within the short-term memory construct. We begin with a detailed critical analysis of the conceptual bases of this view and argue that there are fundamental problems - ones that go to the heart of cognitivism more generally - that render it untenable. In place of limited capacity systems, we propose a framework for explaining performance that focuses on the dynamic interplay of three aspects of any given setting: the particular task that must be accomplished, the nature and form of the material upon which the task must be performed, and the repertoire of skills and perceptual-motor functions possessed by the participant. We provide empirical examples of the applications of this framework in areas of performance typically accounted for by reference to capacity-limited short-term memory processes.

From Awareness to Action: Determining the climate sensitivities that influence decision makers

NASA Astrophysics Data System (ADS)

Brown, C.

2017-12-01

Through the growth of computing power and analytical methods, a range of valuable and innovative tools allow the exhaustive exploration of a water system's response to a limitless set of scenarios. Similarly, possible adaptive actions can be evaluated across this broad set of possible futures. Finally, an ever increasing set of performance indicators is available to judge the relative value of a particular action over others. However, it's unclear whether this is improving the flow of actionable information or further cluttering it. This presentation will share lessons learned and other intuitions from a set of experiences engaging with public and private water managers and investors in the use of robustness-based climate vulnerability and adaptation analysis. Based on this background, a case for reductionism and focus on financial vulnerability will be forwarded. In addition, considerations for simpler, practical approaches for smaller water utilities will be discussed.

Contrast echocardiography: new agents.

PubMed

Miller, Andrew P; Nanda, Navin C

2004-04-01

In this report, we review the history, rationale, current status and future directions of contrast agents in echocardiography. First, we discuss the historic development of contrast agents through a review of important physical principles of microbubbles in ultrasonography. Second, we identify attributes of an ideal contrast agent and review those that are currently available or in the "pipeline" for clinical use. Third, we review indications for contrast echocardiography, including endocardial border detection, perfusion quantification and reperfusion assessment, and validate these observations by comparisons with other imaging modalities. Then, we briefly review different methodologies of performing a contrast study, including interrupted, real-time and a hybrid modality. Finally, we identify novel future applications of the newest contrast agents. These newer concepts in contrast echocardiography should form a foundation for nearly limitless application of echocardiography in improved anatomical assessment, perfusion imaging and even special applications, such as detection of vascular inflammation and site-specific drug delivery.

Education, mental health, and education-labor market misfit.

PubMed

Bracke, Piet; van de Straat, Vera; Missinne, Sarah

2014-12-01

Higher-educated people experience enhanced mental health. We ponder whether the mental health benefits of educational attainment are limitless. At the individual level, we look at the impact of job-education mismatch. At the societal level, we hypothesize that diminishing economic returns on education limit its mental health benefits. Using a subsample of individuals aged 20 to 65 years (N = 28,288) from 21 countries in the European Social Survey (ESS 2006), we estimate the impact on depressive symptoms of characteristics at both the employee level (years of education and job-education mismatch) and the labor market/country level (the gap between the nontertiary and tertiary educated in terms of unemployment risks and earnings). The results show that educational attainment produces mental health benefits in most European countries. However, in some of the countries, these benefits are limited or even completely eliminated by education-labor market misfit. © American Sociological Association 2014.

Graphic artist in computerland

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dolberg, K.M.

1983-01-01

The field of computer graphics is rapidly opening up to the graphic artist. It is not necessary to be a programming expert to enter this fascinating world. The capabilities of the medium are astounding: neon and metallic effects, translucent plastic and clear glass effects, sensitive 3-D shadings, limitless textures, and above all color. As with any medium, computer graphics has its advantages, such as speed, ease of form manipulation, and a variety of type fonts and alphabets. It also has its limitations, such as data input time, final output turnaround time, and not necessarily being the right medium for themore » job at hand. And finally, it is the time- and cost-saving characteristics of computer-generated visuals, opposed to original artwork, that make computer graphics a viable alternative. This paper focuses on parts of the computer graphics system in use at the Los Alamos National Laboratory to provide specific examples.« less

Google Tools in the Classroom

NASA Astrophysics Data System (ADS)

Albee, E. M.; Koons, P. O.; Schauffler, M.; Zhu, Y.; Segee, B. E.

2009-12-01

The Maine Learning Technology Initiative provides every seventh and eighth grade student in the state with MacBook laptop computers. Limitless education possibilities exist with the inclusion of Google Tools and laptops as learning tools in our modern classrooms. Google Applications allow students to create documents, spreadsheets, charts, graphs, forms, and presentations and easily allows the sharing of information with their fellow classmates and teachers. These applications invite the use of inquiry and critical thinking skills, collaboration among peers, and subject integration to teach students crucial concepts. The benefits for teachers extend into the realm of using Google sites to easily create a teacher website and blog to upload classroom information and create a communication connection for parents and students as well as collaborations between the teachers and University researchers and educators. Google Applications further enhances the possibilities for learning, sharing a wealth of information, and enhancing communication inside and outside of the classroom.

Conjunction Assessment Past, Present, and Future

NASA Technical Reports Server (NTRS)

Newman, Lauri K.

2015-01-01

Since 1957, humankind's reliance on the space domain for military, humanitarian, and commercial applications has continued to increase. 1960 first successful use of a meteorological satellite,1963 first use of a geosynchronous communications satellite, 1985 Block I of GPS fielded, 1998 first module of ISS, 2001 first satellite radio broadcast over North America. What you take into space, stays in space: launch vehicle, rocket-bodies, mission-related debris. Debris can also be generated on-orbit: fuel/battery explosions, collisions. Only naturally-occurring retarding effect is orbital decay due to atmospheric drag: some remediation measures available, active debris removal not yet viable option. Because of our reliance on space and the fact that space really isn't limitless, the Big Sky theory is no longer an acceptable risk posture. There have been eight (8) on-orbit collisions reported to date, half of which occurred in the last 10 years.

Statistical significance of combinatorial regulations

PubMed Central

Terada, Aika; Okada-Hatakeyama, Mariko; Tsuda, Koji; Sese, Jun

2013-01-01

More than three transcription factors often work together to enable cells to respond to various signals. The detection of combinatorial regulation by multiple transcription factors, however, is not only computationally nontrivial but also extremely unlikely because of multiple testing correction. The exponential growth in the number of tests forces us to set a strict limit on the maximum arity. Here, we propose an efficient branch-and-bound algorithm called the “limitless arity multiple-testing procedure” (LAMP) to count the exact number of testable combinations and calibrate the Bonferroni factor to the smallest possible value. LAMP lists significant combinations without any limit, whereas the family-wise error rate is rigorously controlled under the threshold. In the human breast cancer transcriptome, LAMP discovered statistically significant combinations of as many as eight binding motifs. This method may contribute to uncover pathways regulated in a coordinated fashion and find hidden associations in heterogeneous data. PMID:23882073

The psychological, political, and economic realities of brain injury rehabilitation in the 1990s.

PubMed

Leri, J E

1995-07-01

Gans, in 1983, detailed the prevalence, causes, and implications of hate in the rehabilitation setting, and offered suggestions for therapeutic responses to it. Mullins, in 1989, noted that during the 1980s rehabilitation became a rapidly expanding, increasingly privatized, big business, with seemingly limitless opportunities for advancement and profit. He asserted that during those years hate had been joined by power, envy and greed in the rehabilitation setting. The present article builds upon the two earlier ones and reviews recent events and their effects, including: the continued development of rehabilitation as a business, the national economic slow down, the health-care crisis, the rise of managed care, the fear that rehabilitation workers feel for their jobs, and the loss of control that people feel throughout rehabilitation. Suggestions for improving the current situation are offered to clinicians, administrators, insurers, and educators, and all are urged to do what they know is right.

How NIF Works

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2009-07-30

The National Ignition Facility, located at Lawrence Livermore National Laboratory, is the world's largest laser system... 192 huge laser beams in a massive building, all focused down at the last moment at a 2 millimeter ball containing frozen hydrogen gas. The goal is to achieve fusion... getting more energy out than was used to create it. It's never been done before under controlled conditions, just in nuclear weapons and in stars. We expect to do it within the next 2-3 years. The purpose is threefold: to create an almost limitless supply of safe, carbon-free, proliferation-free electricity; examine new regimes ofmore » astrophysics as well as basic science; and study the inner-workings of the U.S. stockpile of nuclear weapons to ensure they remain safe, secure and reliable without the need for underground testing. More information about NIF can be found at:« less

Modern problems of thermodynamics

NASA Astrophysics Data System (ADS)

Novikov, I. I.

2012-12-01

The role of energy and methods of its saving for the development of human society and life are analyzed. The importance of future use of space energy flows and energy of water and air oceans is emphasized. The authors consider the idea of the unit for production of electric energy and pure substances using sodium chloride which reserves are limitless on the planet. Looking retrospectively at the development of power engineering from the elementary fire to modern electric power station, we see that the used method of heat production, namely by direct interaction of fuel and oxidizer, is the simplest. However, it may be possible to combust coal, i.e., carbon in salt melt, for instance, sodium chloride that would be more rational and efficient. If the stated problems are solved positively, we would master all energy properties of the substance; and this is the main problem of thermodynamics being one of the sciences on energy.

Community Assembly Processes of the Microbial Rare Biosphere.

PubMed

Jia, Xiu; Dini-Andreote, Francisco; Falcão Salles, Joana

2018-03-14

Our planet teems with microorganisms that often present a skewed abundance distribution in a local community, with relatively few dominant species coexisting alongside a high number of rare species. Recent studies have demonstrated that these rare taxa serve as limitless reservoirs of genetic diversity, and perform disproportionate types of functions despite their low abundances. However, relatively little is known about the mechanisms controlling rarity and the processes promoting the development of the rare biosphere. Here, we propose the use of multivariate cut-offs to estimate rare species and phylogenetic null models applied to predefined rare taxa to disentangle the relative influences of ecoevolutionary processes mediating the assembly of the rare biosphere. Importantly, the identification of the factors controlling rare species assemblages is critical for understanding the types of rarity, how the rare biosphere is established, and how rare microorganisms fluctuate over spatiotemporal scales, thus enabling prospective predictions of ecosystem responses. Copyright © 2018 Elsevier Ltd. All rights reserved.

Controlling Healthcare Costs: Just Cost Effectiveness or "Just" Cost Effectiveness?

PubMed

Fleck, Leonard M

2018-04-01

Meeting healthcare needs is a matter of social justice. Healthcare needs are virtually limitless; however, resources, such as money, for meeting those needs, are limited. How then should we (just and caring citizens and policymakers in such a society) decide which needs must be met as a matter of justice with those limited resources? One reasonable response would be that we should use cost effectiveness as our primary criterion for making those choices. This article argues instead that cost-effectiveness considerations must be constrained by considerations of healthcare justice. The goal of this article will be to provide a preliminary account of how we might distinguish just from unjust or insufficiently just applications of cost-effectiveness analysis to some healthcare rationing problems; specifically, problems related to extraordinarily expensive targeted cancer therapies. Unconstrained compassionate appeals for resources for the medically least well-off cancer patients will be neither just nor cost effective.

Abseq: Ultrahigh-throughput single cell protein profiling with droplet microfluidic barcoding.

PubMed

Shahi, Payam; Kim, Samuel C; Haliburton, John R; Gartner, Zev J; Abate, Adam R

2017-03-14

Proteins are the primary effectors of cellular function, including cellular metabolism, structural dynamics, and information processing. However, quantitative characterization of proteins at the single-cell level is challenging due to the tiny amount of protein available. Here, we present Abseq, a method to detect and quantitate proteins in single cells at ultrahigh throughput. Like flow and mass cytometry, Abseq uses specific antibodies to detect epitopes of interest; however, unlike these methods, antibodies are labeled with sequence tags that can be read out with microfluidic barcoding and DNA sequencing. We demonstrate this novel approach by characterizing surface proteins of different cell types at the single-cell level and distinguishing between the cells by their protein expression profiles. DNA-tagged antibodies provide multiple advantages for profiling proteins in single cells, including the ability to amplify low-abundance tags to make them detectable with sequencing, to use molecular indices for quantitative results, and essentially limitless multiplexing.

Abseq: Ultrahigh-throughput single cell protein profiling with droplet microfluidic barcoding

NASA Astrophysics Data System (ADS)

Shahi, Payam; Kim, Samuel C.; Haliburton, John R.; Gartner, Zev J.; Abate, Adam R.

2017-03-01

Proteins are the primary effectors of cellular function, including cellular metabolism, structural dynamics, and information processing. However, quantitative characterization of proteins at the single-cell level is challenging due to the tiny amount of protein available. Here, we present Abseq, a method to detect and quantitate proteins in single cells at ultrahigh throughput. Like flow and mass cytometry, Abseq uses specific antibodies to detect epitopes of interest; however, unlike these methods, antibodies are labeled with sequence tags that can be read out with microfluidic barcoding and DNA sequencing. We demonstrate this novel approach by characterizing surface proteins of different cell types at the single-cell level and distinguishing between the cells by their protein expression profiles. DNA-tagged antibodies provide multiple advantages for profiling proteins in single cells, including the ability to amplify low-abundance tags to make them detectable with sequencing, to use molecular indices for quantitative results, and essentially limitless multiplexing.

Abseq: Ultrahigh-throughput single cell protein profiling with droplet microfluidic barcoding

PubMed Central

Shahi, Payam; Kim, Samuel C.; Haliburton, John R.; Gartner, Zev J.; Abate, Adam R.

2017-01-01

Proteins are the primary effectors of cellular function, including cellular metabolism, structural dynamics, and information processing. However, quantitative characterization of proteins at the single-cell level is challenging due to the tiny amount of protein available. Here, we present Abseq, a method to detect and quantitate proteins in single cells at ultrahigh throughput. Like flow and mass cytometry, Abseq uses specific antibodies to detect epitopes of interest; however, unlike these methods, antibodies are labeled with sequence tags that can be read out with microfluidic barcoding and DNA sequencing. We demonstrate this novel approach by characterizing surface proteins of different cell types at the single-cell level and distinguishing between the cells by their protein expression profiles. DNA-tagged antibodies provide multiple advantages for profiling proteins in single cells, including the ability to amplify low-abundance tags to make them detectable with sequencing, to use molecular indices for quantitative results, and essentially limitless multiplexing. PMID:28290550

A semantic web framework to integrate cancer omics data with biological knowledge

PubMed Central

2012-01-01

Background The RDF triple provides a simple linguistic means of describing limitless types of information. Triples can be flexibly combined into a unified data source we call a semantic model. Semantic models open new possibilities for the integration of variegated biological data. We use Semantic Web technology to explicate high throughput clinical data in the context of fundamental biological knowledge. We have extended Corvus, a data warehouse which provides a uniform interface to various forms of Omics data, by providing a SPARQL endpoint. With the querying and reasoning tools made possible by the Semantic Web, we were able to explore quantitative semantic models retrieved from Corvus in the light of systematic biological knowledge. Results For this paper, we merged semantic models containing genomic, transcriptomic and epigenomic data from melanoma samples with two semantic models of functional data - one containing Gene Ontology (GO) data, the other, regulatory networks constructed from transcription factor binding information. These two semantic models were created in an ad hoc manner but support a common interface for integration with the quantitative semantic models. Such combined semantic models allow us to pose significant translational medicine questions. Here, we study the interplay between a cell's molecular state and its response to anti-cancer therapy by exploring the resistance of cancer cells to Decitabine, a demethylating agent. Conclusions We were able to generate a testable hypothesis to explain how Decitabine fights cancer - namely, that it targets apoptosis-related gene promoters predominantly in Decitabine-sensitive cell lines, thus conveying its cytotoxic effect by activating the apoptosis pathway. Our research provides a framework whereby similar hypotheses can be developed easily. PMID:22373303

The New Solar System: China’s Evolving Solar Industry and Its Implications for Competitive Solar Power in the United States and the World

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ball, Jeffrey; Reicher, Dan; Sun, Xiaojing

Solar power is undergoing a revolution. Over the past decade, an energy source as old as the planet and theoretically all but limitless has plummeted in cost and begun in some places to be harnessed in large volume. This dynamic is disrupting the modern energy system and, as energy disruptions always do, rattling the geopolitical order. In the process, the industry that produces the equipment to convert sunlight into electricity is simultaneously reeling, consolidating, and surging. These twin transformations—one of the global energy system, one of the global solar industry—carry profound implications for national economies and for the planet. Atmore » the center of both transformations sits China. The New Solar System illuminates key and little- understood changes that are remaking the solar enterprise—in China and thus in the world. Based on this analysis, it recommends changes in U.S. solar policy—particularly timely with a new U.S. administration and Congress—that would put solar power on a more economically sensible path toward environmentally significant growth. The New Solar System does not seek to enable any country to beat another in the global solar industry. It seeks instead to help all countries find their most effective places. By better understanding and playing to their comparative strengths in the solar business, countries would achieve two key objectives. They would reduce the cost for the world of scaling up solar power. And they would be better positioned to fashion policies that maximized the long-term benefit to their own economies from solar’s global growth.« less

Self creation and the limitless void of dissociation: the 'as if' personality.

PubMed

McFarland Solomon, Hester

2004-11-01

The concept of the 'as if' personality has been used variously in analytic literature without having formed part of a clinically based theoretical development over time. The author discusses the bases of her notion of the 'as if' personality, as observed across a number of patients and supervised patients in intensive, long term analytic treatment. In this composite clinical picture, a grouping of elements that form a particular kind of defence of the self is identified in certain patients with an exceptional capacity for creative engagement in the world, surpassing expectations given their background. The picture includes the presence of physical breakdown and illness, as psychic suffering arising from early narcissistic wounding and from a physical, emotional and/or sexual abusive familial environment, was held for too long in bodily memory but not in mind. A distinction is made between the 'as if' personality, the persona and the false self. The 'as if' personality concerns the action of defensive dissociation deriving from very early experiences of internalizing the presence of an absent object, creating the sense of an internal void at the core of the self. At the same time, the self is capable of acts of self creation through a succession of identifications and internalizations with other sources of environmental nourishment, which substitute for, and are constructed around, the original sense of internal emptiness. Thus are restored, but only up to a point, the resources of the originally diminished self. Until these resources have been used up, the self is often able to excel in activities to an exceptional degree. The countertransference is shown to be the means of both useful but often perilously obtained clinical experience and information, supporting the work along the hazardous analytic journey.

Using Augusto Boal-based theatre for development methods to mediate the introduction of fuel-efficient cook stoves in Chajul, Guatemala: provoking action through an ethical intervention

NASA Astrophysics Data System (ADS)

Bisping, Jason

2011-12-01

This dissertation examines how theatre for development methods, developed and influenced by Augusto Boal, were employed to provide energy-oppressed people with opportunities to reflect and take action to improve their lives. Specifically, this research study examines two theatre for development interventions conducted in Chajul, Guatemala, where I worked with indigenous citizens of Chajul and a host nongovernmental organization, Limitless Horizons Ixil, to create theatre pieces that confronted people's home energy-use habits, focusing, specifically, on the dangers of indoor air pollution caused by the use of open fires in homes. The first intervention occurred during a seven-day trip to Chajul in July 2009, and involved devising and staging an original play, "Life with a Cookstove/Life without a Cookstove," that was presented to more than 300 community members. The second intervention, which took place over ten days in June 2010, consisted of staging original theatre pieces in people's homes around their open fires. In addition to using theatre as an educational tool, information was collected about people's attitudes and behaviors related to indoor air pollution and cookstoves. Additionally, the theatre interventions gave people the opportunity to practice taking action to reduce dangers associated with indoor air pollution in their homes through the proposed use of cookstoves. This investigation provides insight into common theatre for development practices that can be used in Latin America, a portion of the world that has been significantly understudied, and with other underrepresented populations around the world that are not accustomed to using theatre to reflect on their home energy use or other significant issues of concern in need of action. Additionally, this research assisted Limitless Horizons Ixil to achieve its development goals of reducing indoor air pollution in Chajul through the introduction of cookstoves in an ethical and sustainable way. As the only study on using theatre for development methods to introduce, investigate, and promote cookstoves as an appropriate and sustainable energy technology, this research serves as an example of employing participatory and ethical theatre for energy justice methods to provide people with opportunities to reflect on and take action to solve their energy needs.

Morphogenesis of nanostructures in glancing angle deposition of metal thin film coatings

NASA Astrophysics Data System (ADS)

Brown, Timothy James

Atomic vapors condensed onto solid surfaces form a remarkable category of condensed matter materials, the so-called thin films, with a myriad of compositions, morphological structures, and properties. The dynamic process of atomic condensation exhibits self-assembled pattern formation, producing morphologies with atomic-scale three- dimensional structures of seemingly limitless variety. This study attempts to shed new light on the dynamical growth processes of thin film deposition by analyzing in detail a previously unreported specific distinct emergent structure, a crystalline triangular-shaped spike that grows within copper and silver thin films. I explored the deposition parameters that lead to the growth of these unique structures, referred to as "nanospikes", fabricating approximately 55 thin films and used scanning electron microscopy and x-ray diffraction analysis. The variation of parameters include: vapor incidence angle, film thickness, substrate temperature, deposition rate, deposition material, substrate, and source-to-substrate distance. Microscopy analysis reveals that the silver and copper films deposited at glancing vapor incidence angles, 80 degrees and greater, have a high degree of branching interconnectivity between adjacent inclined nanorods. Diffraction analysis reveals that the vapor incidence angle influences the sub-populations of crystallites in the films, producing two different [110] crystal texture orientations. I hypothesize that the growth of nanospikes from nanorods is initiated by the stochastic arrival of vapor atoms and photons emitted from the deposition source at small diameter nanorods, and then driven by localized heating from vapor condensation and photon absorption. Restricted heat flow due to nanoscale thermal conduction maintains an elevated local temperature at the nanorod, enhancing adatom diffusion and enabling fast epitaxial crystal growth, leading to the formation and growth of nanospikes. Electron microscopy and x-ray diffraction analysis, and comparisons to related scientific literature, support this hypothesis. I also designed a highly modular ultrahigh vacuum deposition chamber, capable of concurrently mounting several different pieces of deposition equipment, that allows for a high degree of control of the growth dynamics of deposited thin films. I used the newly designed chamber to fabricate tailor-made nanostructured tantalum films for use in ultracapacitors, for the Cabot Corporation.

Usefulness of telepsychiatry: A critical evaluation of videoconferencing-based approaches

PubMed Central

Chakrabarti, Subho

2015-01-01

Telepsychiatry, i.e., the use of information and communication technologies to provide psychiatric services from a distance, has been around for more than half a century now. Research over this period has shown that videoconferencing-based telepsychiatry is an enabling and empowering form of service delivery, which promotes equality of access, and high levels of satisfaction among patients. The range of services offered by videoconferencing-based telepsychiatry, potential users and points of delivery of such services are theoretically limitless. Telepsychiatry has both clinical utility and non-clinical uses such as administrative, learning and research applications. A large body of accumulated evidence indicates that videoconferencing-based telepsychiatric assessments are reliable, and clinical outcomes of telepsychiatric interventions are comparable to conventional treatment among diverse patient populations, ages and diagnostic groups, and on a wide range of measures. However, on many aspects of effectiveness, the evidence base is still relatively limited and often compromised by methodological problems. The lack of cost-effectiveness data in particular, is a major hindrance, raising doubts about the continued viability of telepsychiatric services. Added to this are the vagaries of technology, negative views among clinicians, poor uptake by providers, and several legal, ethical and administrative barriers. These hamper the widespread implementation of telepsychiatry and its integration with routine care. Though further advances in technology and research are expected to solve many of these problems, the way forward would be to promote telepsychiatry as an adjunct to conventional care, and to develop hybrid models, which incorporate both traditional and telepsychiatric forms of mental health-care. PMID:26425443

AID-initiated purposeful mutations in immunoglobulin genes.

PubMed

Goodman, Myron F; Scharff, Matthew D; Romesberg, Floyd E

2007-01-01

Exposure brings risk to all living organisms. Using a remarkably effective strategy, higher vertebrates mitigate risk by mounting a complex and sophisticated immune response to counter the potentially toxic invasion by a virtually limitless army of chemical and biological antagonists. Mutations are almost always deleterious, but in the case of antibody diversification there are mutations occurring at hugely elevated rates within the variable (V) and switch regions (SR) of the immunoglobulin (Ig) genes that are responsible for binding to and neutralizing foreign antigens throughout the body. These mutations are truly purposeful. This chapter is centered on activation-induced cytidine deaminase (AID). AID is required for initiating somatic hypermutation (SHM) in the V regions and class switch recombination (CSR) in the SR portions of Ig genes. By converting C --> U, while transcription takes place, AID instigates a cascade of mutational events involving error-prone DNA polymerases, base excision and mismatch repair enzymes, and recombination pathways. Together, these processes culminate in highly mutated antibody genes and the B cells expressing antibodies that have achieved optimal antigenic binding undergo positive selection in germinal centers. We will discuss the biological role of AID in this complex process, primarily in terms of its biochemical properties in relation to SHM in vivo. The chapter also discusses recent advances in experimental methods to characterize antibody dynamics as a function of SHM to help elucidate the role that the AID-induced mutations play in tailoring molecular recognition. The emerging experimental techniques help to address long-standing conundrums concerning evolution-imposed constraints on antibody structure and function.

Click chemistry, 3D-printing, and omics: the future of drug development.

PubMed

Kurzrock, Razelle; Stewart, David J

2016-01-19

Genomics is a disruptive technology, having revealed that cancers are tremendously complex and differ from patient to patient. Therefore, conventional treatment approaches fit poorly with genomic reality. Furthermore, it is likely that this type of complexity will also be observed in other illnesses. Precision medicine has been posited as a way to better target disease-related aberrations, but developing drugs and tailoring therapy to each patient's complicated problem is a major challenge. One solution would be to match patients to existing compounds based on in silico modeling. However, optimization of complex therapy will eventually require designing compounds for patients using computer modeling and just-in-time production, perhaps achievable in the future by three-dimensional (3D) printing. Indeed, 3D printing is potentially transformative by virtue of its ability to rapidly generate almost limitless numbers of objects that previously required manufacturing facilities. Companies are already endeavoring to develop affordable 3D printers for home use. An attractive, but as yet scantily explored, application is to place chemical design and production under digital control. This could be accomplished by utilizing a 3D printer to initiate chemical reactions, and print the reagents and/or the final compounds directly. Of interest, the Food and Drug Administration (FDA) has recently approved a 3D printed drug-levetiracetam-indicated for seizures. Further, it is now increasingly clear that biologic materials-tissues, and eventually organs-can also be "printed." In the near future, it is plausible that high-throughput computing may be deployed to design customized drugs, which will reshape medicine.

Click chemistry, 3D-printing, and omics: the future of drug development

PubMed Central

Kurzrock, Razelle; Stewart, David J.

2016-01-01

Genomics is a disruptive technology, having revealed that cancers are tremendously complex and differ from patient to patient. Therefore, conventional treatment approaches fit poorly with genomic reality. Furthermore, it is likely that this type of complexity will also be observed in other illnesses. Precision medicine has been posited as a way to better target disease-related aberrations, but developing drugs and tailoring therapy to each patient's complicated problem is a major challenge. One solution would be to match patients to existing compounds based on in silico modeling. However, optimization of complex therapy will eventually require designing compounds for patients using computer modeling and just-in-time production, perhaps achievable in the future by three-dimensional (3D) printing. Indeed, 3D printing is potentially transformative by virtue of its ability to rapidly generate almost limitless numbers of objects that previously required manufacturing facilities. Companies are already endeavoring to develop affordable 3D printers for home use. An attractive, but as yet scantily explored, application is to place chemical design and production under digital control. This could be accomplished by utilizing a 3D printer to initiate chemical reactions, and print the reagents and/or the final compounds directly. Of interest, the Food and Drug Administration (FDA) has recently approved a 3D printed drug—levetiracetam—indicated for seizures. Further, it is now increasingly clear that biologic materials—tissues, and eventually organs—can also be “printed.” In the near future, it is plausible that high-throughput computing may be deployed to design customized drugs, which will reshape medicine. PMID:26734837

The common neural parasite Pseudoloma neurophilia is associated with altered startle response habituation in adult zebrafish (Danio rerio): Implications for the zebrafish as a model organism

PubMed Central

Spagnoli, Sean; Xue, Lan; Kent, Michael L.

2015-01-01

The zebrafish’s potential as a model for human neurobehavioral research appears nearly limitless despite its relatively recent emergence as an experimental organism. Since the zebrafish has only been part of the research community for a handful of decades, pathogens from its commercial origins continue to plague laboratory stocks. One such pathogen is Pseudoloma neurophilia, a common microparasite in zebrafish laboratories world-wide that generally produces subclinical infections. Given its high prevalence, its predilection for the host’s brain and spinal cord, and the delicate nature of neurobehavioral research, the behavioral consequences of subclinical P. neurophilia infection must be explored. Fish infected via cohabitation were tested for startle response habituation in parallel with controls in a device that administered ten taps over ten minutes along with taps at 18 and 60 minutes to evaluate habituation extinction. After testing, fish were euthanized and evaluated for infection via histopathology. Infected fish had a significantly smaller reduction in startle velocity during habituation compared to uninfected tankmates and controls. Habituation was eliminated in infected and control fish at 18 minutes, whereas exposed negative fish retained partial habituation at 18 minutes. Infection was also associated with enhanced capture evasion: Despite the absence of external symptoms, infected fish tended to be caught later than uninfected fish netted from the same tank. The combination of decreased overall habituation, early extinction of habituation compared to uninfected cohorts, and enhanced netting evasion indicates that P. neurophilia infection is associated with a behavioral phenotype distinct from that of controls and uninfected cohorts. Because of its prevalence in zebrafish facilities, P. neurophilia has the potential to insidiously influence a wide range of neurobehavioral studies if these associations are causative. Rigorous health screening is therefore vital to the improvement of the zebrafish as a translational model for human behavior. PMID:26028515

The common neural parasite Pseudoloma neurophilia is associated with altered startle response habituation in adult zebrafish (Danio rerio): Implications for the zebrafish as a model organism.

PubMed

Spagnoli, Sean; Xue, Lan; Kent, Michael L

2015-09-15

The zebrafish's potential as a model for human neurobehavioral research appears nearly limitless despite its relatively recent emergence as an experimental organism. Since the zebrafish has only been part of the research community for a handful of decades, pathogens from its commercial origins continue to plague laboratory stocks. One such pathogen is Pseudoloma neurophilia, a common microparasite in zebrafish laboratories world-wide that generally produces subclinical infections. Given its high prevalence, its predilection for the host's brain and spinal cord, and the delicate nature of neurobehavioral research, the behavioral consequences of subclinical P. neurophilia infection must be explored. Fish infected via cohabitation were tested for startle response habituation in parallel with controls in a device that administered ten taps over 10 min along with taps at 18 and 60 min to evaluate habituation extinction. After testing, fish were euthanized and evaluated for infection via histopathology. Infected fish had a significantly smaller reduction in startle velocity during habituation compared to uninfected tankmates and controls. Habituation was eliminated in infected and control fish at 18 min, whereas exposed negative fish retained partial habituation at 18 min. Infection was also associated with enhanced capture evasion: Despite the absence of external symptoms, infected fish tended to be caught later than uninfected fish netted from the same tank. The combination of decreased overall habituation, early extinction of habituation compared to uninfected cohorts, and enhanced netting evasion indicates that P. neurophilia infection is associated with a behavioral phenotype distinct from that of controls and uninfected cohorts. Because of its prevalence in zebrafish facilities, P. neurophilia has the potential to insidiously influence a wide range of neurobehavioral studies if these associations are causative. Rigorous health screening is therefore vital to the improvement of the zebrafish as a translational model for human behavior. Copyright © 2015 Elsevier B.V. All rights reserved.

[Case histories and other stories in the multimedia era... but was there something else?...].

PubMed

Kohler, Hans-Peter

2010-12-01

The multimedia era is fascinating and limitless! The advances in the field of consumer and entertainment electronics are impressive. Our private as well as business life is very much accompanied and influenced by numerous technical gadgets. These advancements should have many positive implications on our clinical work. Do they? Using modern personal computers and clinic information systems (CIS) the access to patients' data, the prescription of drugs, or x-ray diagnostics on high-resolution laptop screens became as easy as pie. This affects the doctor-patient relationship but also the communication between physicians and nurses. Computers also affect our daily clinical work and therefore the treatment of our patients. Do our patients take benefit from these technical achievements? Does the use of clinic information systems positively influence diagnosis, treatment and finally patient outcome but also doctors' performances? What has really changed in the last couples of years? The present article tries to critically review these major changes in patient care.

Color in graphic design: an analysis of meaning and trends

NASA Astrophysics Data System (ADS)

Martinson, Barbara; Waldron, Carol C.

2002-06-01

Graphic design is visual communication through the selection, arrangement, and presentation of words and images, most often for the printed page which offer the designer almost limitless options for color use. The objective of this project is to identify patterns of color use. Ethnographic content analysis was used to document color use in annual reports represented in two publications, Print and Communication Arts, 1993-2000. The analysis focuses on the selection, combination, and contrast of hues; and their use with achromatic values. An analysis of the entire sample indicates that one-third of the annual reports used a palette that include black, white, and a hue from quadrant one (red to yellow). Nearly one-fifth of the designs used black, white, and colors from quadrants one and three (cyan to blue). The large samples for Technology, Health Sciences, Financial, and Civic organizations follow the first pattern. Food Service, Business products and services, and Transportation industries favor the second pattern.

A vocabulary of ancient peptides at the origin of folded proteins

PubMed Central

Alva, Vikram; Söding, Johannes; Lupas, Andrei N

2015-01-01

The seemingly limitless diversity of proteins in nature arose from only a few thousand domain prototypes, but the origin of these themselves has remained unclear. We are pursuing the hypothesis that they arose by fusion and accretion from an ancestral set of peptides active as co-factors in RNA-dependent replication and catalysis. Should this be true, contemporary domains may still contain vestiges of such peptides, which could be reconstructed by a comparative approach in the same way in which ancient vocabularies have been reconstructed by the comparative study of modern languages. To test this, we compared domains representative of known folds and identified 40 fragments whose similarity is indicative of common descent, yet which occur in domains currently not thought to be homologous. These fragments are widespread in the most ancient folds and enriched for iron-sulfur- and nucleic acid-binding. We propose that they represent the observable remnants of a primordial RNA-peptide world. DOI: http://dx.doi.org/10.7554/eLife.09410.001 PMID:26653858

Researching Lived Experience of Drugs and Crime: A Phenomenological Study of Drug-Dependent Inmates.

PubMed

Facchin, Federica; Margola, Davide

2016-10-01

This study identified the main components of the drugs and crime experience of a sample of 25 drug-dependent inmates interviewed in prison. Text analyses were conducted using a phenomenological method. The sample was characterized by a disruptive childhood in multi-problematic families and deviant social contexts where drug use and crime were considered normal since early adolescence. Drug initiation involved recreational use of dance drugs and/or cocaine, and the pleasure experienced was identified as the cause of subsequent persistent use. Three pathways that led to dependence were identified: The narcissistic pathway was defined as involving uncontrolled cocaine and amphetamines to feel powerful and limitless. The posttraumatic pathway was defined as involving post-trauma self-destructive drug use, while the pain relief pathway was defined as involving multiple substances to relieve pain. The second and third pathways were more directly associated with crime aimed at sustaining drug use. © The Author(s) 2015.

The Major Histocompatibility Complex in Bovines: A Review

PubMed Central

Behl, Jyotsna Dhingra; Verma, N. K.; Tyagi, Neha; Mishra, Priyanka; Behl, Rahul; Joshi, B. K.

2012-01-01

Productivity in dairy cattle and buffaloes depends on the genetic factors governing the production of milk and milk constituents as well as genetic factors controlling disease resistance or susceptibility. The immune system is the adaptive defense system that has evolved in vertebrates to protect them from invading pathogens and also carcinomas. It is remarkable in the sense that it is able to generate an enormous variety of cells and biomolecules which interact with each other in numerous ways to form a complex network that helps to recognize, counteract, and eliminate the apparently limitless number of foreign invading pathogens/molecules. The major histocompatibility complex which is found to occur in all mammalian species plays a central role in the development of the immune system. It is an important candidate gene involved in susceptibility/resistance to various diseases. It is associated with intercellular recognition and with self/nonself discrimination. It plays major role in determining whether transplanted tissue will be accepted as self or rejected as foreign. PMID:23738132

Creating a vision for your medical call center.

PubMed

Barr, J L; Laufenberg, S; Sieckman, B L

1998-01-01

MCC technologies and applications that can have a positive impact on managed care delivery are almost limitless. As you determine your vision, be sure to have in mind the following questions: (1) Do you simply want an efficient front end for receiving calls? (2) Do you want to offer triage services? (3) Is your organization ready for a fully functional "electronic physician's office?" Understand your organization's strategy. Where are you going, not only today but five years from now? That information is essential to determine your vision. Once established, your vision will help determine what you need and whether you should build or outsource. Vendors will assist in cost/benefit analysis of their equipment, but do not lose sight of internal factors such as "prior inclination" costs in the case of a nurse triage program. The technology is available to take your vision to its outer reaches. With the projected increase in utilization of call center services, don't let your organization be left behind!

Clinical review: Ethics and end-of-life care for critically ill patients in China.

PubMed

Li, Li Bin

2013-12-04

Critical care medicine in China has made great advances in recent decades. This has led to an unavoidable issue: end-of-life ethics. With advances in medical technology and therapeutics allowing the seemingly limitless maintenance of life, the exact time of death of an individual patient is often determined by the decision to limit life support. How to care for patients at the end of life is not only a medical problem but also a social, ethical, and legal issue. A lot of factors, besides culture, come into play in determining a person's ethical attitudes or behaviors, such as experience, education, religion, individual attributes, and economic considerations. Chinese doctors face ethical problems similar to those of their Western counterparts; however, since Chinese society is different from that of Western countries in cultural traditions, customs, religious beliefs, and ethnic backgrounds, there is a great difference between China and the Western world in regard to ethics at the end of life, and there is also a huge controversy within China.

Proceedings of the High Consequence Operations Safety Symposium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1994-12-01

Many organizations face high consequence safety situations where unwanted stimuli due to accidents, catastrophes, or inadvertent human actions can cause disasters. In order to improve interaction among such organizations and to build on each others` experience, preventive approaches, and assessment techniques, the High Consequence Operations Safety Symposium was held July 12--14, 1994 at Sandia National Laboratories, Albuquerque, New Mexico. The symposium was conceived by Dick Schwoebel, Director of the SNL Surety Assessment Center. Stan Spray, Manager of the SNL System Studies Department, planned strategy and made many of the decisions necessary to bring the concept to fruition on a shortmore » time scale. Angela Campos and about 60 people worked on the nearly limitless implementation and administrative details. The initial symposium (future symposia are planned) was structured around 21 plenary presentations in five methodology-oriented sessions, along with a welcome address, a keynote address, and a banquet address. Poster papers addressing the individual session themes were available before and after the plenary sessions and during breaks.« less

Fast physical-random number generation using laser diode's frequency noise: influence of frequency discriminator

NASA Astrophysics Data System (ADS)

Matsumoto, Kouhei; Kasuya, Yuki; Yumoto, Mitsuki; Arai, Hideaki; Sato, Takashi; Sakamoto, Shuichi; Ohkawa, Masashi; Ohdaira, Yasuo

2018-02-01

Not so long ago, pseudo random numbers generated by numerical formulae were considered to be adequate for encrypting important data-files, because of the time needed to decode them. With today's ultra high-speed processors, however, this is no longer true. So, in order to thwart ever-more advanced attempts to breach our system's protections, cryptologists have devised a method that is considered to be virtually impossible to decode, and uses what is a limitless number of physical random numbers. This research describes a method, whereby laser diode's frequency noise generate a large quantities of physical random numbers. Using two types of photo detectors (APD and PIN-PD), we tested the abilities of two types of lasers (FP-LD and VCSEL) to generate random numbers. In all instances, an etalon served as frequency discriminator, the examination pass rates were determined using NIST FIPS140-2 test at each bit, and the Random Number Generation (RNG) speed was noted.

HER2 signaling drives DNA anabolism and proliferation through SRC-3 phosphorylation and E2F1-regulated genes

PubMed Central

Nikolai, Bryan C.; Lanz, Rainer B.; York, Brian; Dasgupta, Subhamoy; Mitsiades, Nicholas; Creighton, Chad J.; Tsimelzon, Anna; Hilsenbeck, Susan G.; Lonard, David M.; Smith, Carolyn L.; O’Malley, Bert W.

2016-01-01

Approximately 20% of early-stage breast cancers display amplification or overexpression of the ErbB2/HER2 oncogene, conferring poor prognosis and resistance to endocrine therapy. Targeting HER2+ tumors with trastuzumab or the receptor tyrosine kinase (RTK) inhibitor lapatinib significantly improves survival, yet tumor resistance and progression of metastatic disease still develop over time. While the mechanisms of cytosolic HER2 signaling are well studied, nuclear signaling components and gene regulatory networks that bestow therapeutic resistance and limitless proliferative potential are incompletely understood. Here, we use biochemical and bioinformatic approaches to identify effectors and targets of HER2 transcriptional signaling in human breast cancer. Phosphorylation and activity of the Steroid Receptor Coactivator-3 (SRC-3) is reduced upon HER2 inhibition, and recruitment of SRC-3 to regulatory elements of endogenous genes is impaired. Transcripts regulated by HER2 signaling are highly enriched with E2F1 binding sites and define a gene signature associated with proliferative breast tumor subtypes, cell cycle progression, and DNA replication. We show that HER2 signaling promotes breast cancer cell proliferation through regulation of E2F1-driven DNA metabolism and replication genes together with phosphorylation and activity of the transcriptional coactivator SRC-3. Furthermore, our analyses identified a cyclin dependent kinase (CDK) signaling node that, when targeted using the CDK4/6 inhibitor Palbociclib, defines overlap and divergence of adjuvant pharmacological targeting. Importantly, lapatinib and palbociclib strictly block de novo synthesis of DNA, mostly through disruption of E2F1 and its target genes. These results have implications for rational discovery of pharmacological combinations in pre-clinical models of adjuvant treatment and therapeutic resistance. PMID:26833126

A Range Finding Protocol to Support Design for Transcriptomics Experimentation: Examples of In-Vitro and In-Vivo Murine UV Exposure

PubMed Central

van Oostrom, Conny T.; Jonker, Martijs J.; de Jong, Mark; Dekker, Rob J.; Rauwerda, Han; Ensink, Wim A.; de Vries, Annemieke; Breit, Timo M.

2014-01-01

In transcriptomics research, design for experimentation by carefully considering biological, technological, practical and statistical aspects is very important, because the experimental design space is essentially limitless. Usually, the ranges of variable biological parameters of the design space are based on common practices and in turn on phenotypic endpoints. However, specific sub-cellular processes might only be partially reflected by phenotypic endpoints or outside the associated parameter range. Here, we provide a generic protocol for range finding in design for transcriptomics experimentation based on small-scale gene-expression experiments to help in the search for the right location in the design space by analyzing the activity of already known genes of relevant molecular mechanisms. Two examples illustrate the applicability: in-vitro UV-C exposure of mouse embryonic fibroblasts and in-vivo UV-B exposure of mouse skin. Our pragmatic approach is based on: framing a specific biological question and associated gene-set, performing a wide-ranged experiment without replication, eliminating potentially non-relevant genes, and determining the experimental ‘sweet spot’ by gene-set enrichment plus dose-response correlation analysis. Examination of many cellular processes that are related to UV response, such as DNA repair and cell-cycle arrest, revealed that basically each cellular (sub-) process is active at its own specific spot(s) in the experimental design space. Hence, the use of range finding, based on an affordable protocol like this, enables researchers to conveniently identify the ‘sweet spot’ for their cellular process of interest in an experimental design space and might have far-reaching implications for experimental standardization. PMID:24823911

Just-in-time cost-effective off-the-shelf remote telementoring of paramedical personnel in bedside lung sonography-a technical case study.

PubMed

Biegler, Nancy; McBeth, Paul B; Tevez-Molina, Martha C; McMillan, Janelle; Crawford, Innes; Hamilton, Douglas R; Kirkpatrick, Andrew W

2012-12-01

Remote telementored ultrasound (RTMUS) is a new discipline that allows a remote expert to guide variably experienced clinical responders through focused ultrasound examinations. We used the examination of the pleural spaces after tube thoracostomy (TT) removal by a nurse with no prior ultrasound experience as an illustrative but highly accurate example of the technique using a simple cost-effective system. The image outputs of a handheld ultrasound machine and a head-mounted Web camera were input into a customized graphical user interface and streamed over a freely available voice over Internet protocol system that allowed two-way audio and visual communication between the novice examiner and the remote expert. The bedside nurse was then guided to examine the anterior chest of a patient who had recently had bilateral TTs removed. The team sought to determine the presence or absence of any recurrent pneumothoraces using the standard criteria for the ultrasound diagnosis of post-removal pneumothorax (PTXs). An upright chest radiograph (CXR) was obtained immediately after the RTMUS examination. The RTMUS system enabled the novice user to learn how to hold the ultrasound probe, where to place it on the chest, and thereafter to diagnose a subtle unilateral PTX characterized as "tiny" on the subsequent formal CXR report. As ultrasound has almost limitless clinical utility, using simple but advanced informatics and communication technologies has potential to improve worldwide healthcare delivery. RTMUS could be used both to enhance the information content as well as to digitally document important physiologic findings in any clinical encounter wherever a portable ultrasound and Internet connectivity are available.

Preparing for evil.

PubMed

Mitroff, Ian I; Alpaslan, Murat C

2003-04-01

How can you plan for every crisis that might occur, even for ones you can't imagine? The task seems so daunting and so limitless that many firms don't even start. In fact, as the authors' 20 years of research shows, three out of four Fortune 500 companies are prepared to handle only the types of calamities they've already suffered, and not even all of those. That's unfortunate because the research also shows that crisis-prepared companies fare better financially, have stronger reputations, and ultimately stay in business longer than their crisis prone counterparts. Crisis-prepared companies use a systematic approach to focus their efforts. In addition to planning for natural disasters, they divide man-made calamities into two sorts--accidental or "normal" ones, like the Exxon Valdez oil spill, and deliberate or "abnormal" ones, like product tampering. Then they take steps to broaden their thinking about such potential crises. They consider threats that would be common in other industries, for instance. And they seek input from outsiders such as investigative journalists and even reformed criminals. But if these companies think broadly about possible threats, they think narrowly about implementation. Each year, smart companies focus their resources and attention on a few facilities picked at random, just as airlines conduct detailed security checks on just a few passengers for each flight. That reduces the probability of an attack on the entire organization even as it allows the business to migrate steadily to a higher level of crisis readiness. Crisis-prepared companies know that disasters cannot be managed through cost-benefit analyses. It is precisely because the effects of a disaster cannot be predicted or controlled that smart companies focus their efforts on preventing crises rather than containing them after the fact.

Biologically Active Secondary Metabolites from the Fungi.

PubMed

Bills, Gerald F; Gloer, James B

2016-11-01

Many Fungi have a well-developed secondary metabolism. The diversity of fungal species and the diversification of biosynthetic gene clusters underscores a nearly limitless potential for metabolic variation and an untapped resource for drug discovery and synthetic biology. Much of the ecological success of the filamentous fungi in colonizing the planet is owed to their ability to deploy their secondary metabolites in concert with their penetrative and absorptive mode of life. Fungal secondary metabolites exhibit biological activities that have been developed into life-saving medicines and agrochemicals. Toxic metabolites, known as mycotoxins, contaminate human and livestock food and indoor environments. Secondary metabolites are determinants of fungal diseases of humans, animals, and plants. Secondary metabolites exhibit a staggering variation in chemical structures and biological activities, yet their biosynthetic pathways share a number of key characteristics. The genes encoding cooperative steps of a biosynthetic pathway tend to be located contiguously on the chromosome in coregulated gene clusters. Advances in genome sequencing, computational tools, and analytical chemistry are enabling the rapid connection of gene clusters with their metabolic products. At least three fungal drug precursors, penicillin K and V, mycophenolic acid, and pleuromutilin, have been produced by synthetic reconstruction and expression of respective gene clusters in heterologous hosts. This review summarizes general aspects of fungal secondary metabolism and recent developments in our understanding of how and why fungi make secondary metabolites, how these molecules are produced, and how their biosynthetic genes are distributed across the Fungi. The breadth of fungal secondary metabolite diversity is highlighted by recent information on the biosynthesis of important fungus-derived metabolites that have contributed to human health and agriculture and that have negatively impacted crops, food distribution, and human environments.

The Generation of Human γδT Cell-Derived Induced Pluripotent Stem Cells from Whole Peripheral Blood Mononuclear Cell Culture.

PubMed

Watanabe, Daisuke; Koyanagi-Aoi, Michiyo; Taniguchi-Ikeda, Mariko; Yoshida, Yukiko; Azuma, Takeshi; Aoi, Takashi

2018-01-01

γδT cells constitute a small proportion of lymphocytes in peripheral blood. Unlike αβT cells, the anti-tumor activities are exerted through several different pathways in a MHC-unrestricted manner. Thus, immunotherapy using γδT cells is considered to be effective for various types of cancer. Occasionally, however, ex vivo expanded cells are not as effective as expected due to cell exhaustion. To overcome the issue of T-cell exhaustion, researchers have generated induced pluripotent stem cells (iPSCs) that harbor the same T-cell receptor (TCR) genes as their original T-cells, which provide nearly limitless sources for antigen-specific cytotoxic T lymphocytes (CTLs). However, these technologies have focused on αβT cells and require a population of antigen-specific CTLs, which are purified by cell sorting with HLA-peptide multimer, as the origin of iPS cells. In the present study, we aimed to develop an efficient and convenient system for generating iPSCs that harbor rearrangements of the TCRG and TCRD gene regions (γδT-iPSCs) without cell-sorting. We stimulated human whole peripheral blood mononuclear cell (PBMC) culture using Interleukin-2 and Zoledronate to activate γδT cells. Gene transfer into those cells with the Sendai virus vector resulted in γδT cell-dominant expression of exogenous genes. The introduction of reprogramming factors into the stimulated PBMC culture allowed us to establish iPSC lines. Around 70% of the established lines carried rearrangements at the TCRG and TCRD gene locus. The γδT-iPSCs could differentiate into hematopoietic progenitors. Our technology will pave the way for new avenues toward novel immunotherapy that can be applied for various types of cancer. Stem Cells Translational Medicine 2018;7:34-44. © 2017 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press.

Where Do Data Go When They Die? Attaining Data Salvation Through the Establishment of a Solar Dynamo Dataverse

NASA Astrophysics Data System (ADS)

Munoz-Jaramillo, Andres

2016-05-01

The arrival of a highly interconnected digital age with practically limitless data storage capacity has brought with it a significant shift in which scientific data is stored and distributed (i.e. from being in the hands of a small group of scientists to being openly and freely distributed for anyone to use). However, the vertiginous speed at which hardware, software, and the nature of the internet changes has also sped up the rate at which data is lost due to formatting obsolescence and loss of access.This poster is meant to advertise the creation of a highly permanent data repository (within the context of Harvard's Dataverse), curated to contain datasets of high relevance for the study, and prediction of the solar dynamo, solar cycle, and long-term solar variability. This repository has many advantages over traditional data storage like the assignment of unique DOI identifiers for each database (making it easier for scientist to directly cite them), and the automatic versioning of each database so that all data are able to attain salvation.

Clinical review: Ethics and end-of-life care for critically ill patients in China

PubMed Central

2013-01-01

Critical care medicine in China has made great advances in recent decades. This has led to an unavoidable issue: end-of-life ethics. With advances in medical technology and therapeutics allowing the seemingly limitless maintenance of life, the exact time of death of an individual patient is often determined by the decision to limit life support. How to care for patients at the end of life is not only a medical problem but also a social, ethical, and legal issue. A lot of factors, besides culture, come into play in determining a person’s ethical attitudes or behaviors, such as experience, education, religion, individual attributes, and economic considerations. Chinese doctors face ethical problems similar to those of their Western counterparts; however, since Chinese society is different from that of Western countries in cultural traditions, customs, religious beliefs, and ethnic backgrounds, there is a great difference between China and the Western world in regard to ethics at the end of life, and there is also a huge controversy within China. PMID:24313980

Investigation of FeNiCrWMn - a new high entropy alloy

NASA Astrophysics Data System (ADS)

Buluc, G.; Florea, I.; Bălţătescu, O.; Florea, R. M.; Carcea, I.

2015-11-01

The term of high entropy alloys started from the analysis of multicomponent alloys, which were produced at an experimental level since 1995 by developing a new concept related to the development of metallic materials. Recent developments in the field of high-entropy alloys have revealed that they have versatile properties like: ductility, toughness, hardness and corrosion resistance [1]. Up until now, it has been demonstrated that the explored this alloys are feasible to be synthesized, processed and analyzed contrary to the misunderstanding based on traditional experiences. Moreover, there are many opportunities in this field for academic studies and industrial applications [1, 2]. As the combinations of composition and process for producing high entropy alloys are numerous and each high entropy alloy has its own microstructure and properties to be identified and understood, the research work is truly limitless. The novelty of these alloys consists of chemical composition. These alloys have been named high entropy alloys due to the atomic scale mixing entropies higher than traditional alloys. In this paper, I will present the microscopy and the mechanical properties of high entropy alloy FeNiCrWMn.

Ultralow bias power all-optical photonic crystal memory realized with systematically tuned L3 nanocavity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kuramochi, Eiichi, E-mail: kuramochi.eiichi@lab.ntt.co.jp; Nozaki, Kengo; Shinya, Akihiko

2015-11-30

An InP photonic crystal nanocavity with an embedded InGaAsP active region is a unique technology that has realized an all-optical memory with a sub-micro-watt operating power and limitless storage time. In this study, we employed an L3 design with systematic multi-hole tuning, which realized a higher loaded Q factor (>40 000) and a lower mode volume (0.9 μm{sup 3}) than a line-defect-based buried-heterostructure nanocavity (16 000 and 2.2 μm{sup 3}). Excluding the active region realized a record loaded Q factor (210 000) in all for InP-based nanocavities. The minimum bias power for bistable memory operation was reduced to 2.3 ± 0.3 nW, which is about 1/10 ofmore » the previous record of 30 nW. This work further established the capability of a bistable nanocavity memory for use in future ultralow-power-consumption on-chip integrated photonics.« less

PRECISION INTEGRATOR FOR MINUTE ELECTRIC CURRENTS

DOEpatents

Hemmendinger, A.; Helmer, R.J.

1961-10-24

An integrator is described for measuring the value of integrated minute electrical currents. The device consists of a source capacitor connected in series with the source of such electrical currents, a second capacitor of accurately known capacitance and a source of accurately known and constant potential, means responsive to the potentials developed across the source capacitor for reversibly connecting the second capacitor in series with the source of known potential and with the source capacitor and at a rate proportional to the potential across the source capacitor to maintain the magnitude of the potential across the source capacitor at approximately zero. (AEC)

Escaping from Rejection

PubMed Central

Lynch, Raymond J.; Platt, Jeffrey L.

2009-01-01

Summary Those engaged in clinical transplantation and transplantation immunology have always taken as a central objective the elucidation of means to prevent graft rejection by the recipient immune system. Conceptually, such mechanisms stem from the concept of Paul Ehrlich that all organisms can selectively avoid autotoxicity; i.e. they exhibit horror autotoxicus. Some mechanisms of horror autotoxicus now understood. T lymphocytes and B lymphocytes recognize foreign antigens but not some auto-antigens. Clonal deletion generates lacunae in what is otherwise a virtually limitless potential to recognize antigens. We call this mechanism structural tolerance. Where imperfections in structural tolerance allow self-recognition, the full activation of lymphocytes and generation of effector activity depends on delivery of accessory signals generated by infection and/or injury. The absence of accessory signals prevents or even suppresses immunological responses. We call this dichotomy of responsiveness conditional tolerance. When, despite structural and conditional tolerance, effector activity perturbs autologous cells, metabolism changes in ways that protect against injury. We use the term accommodation to refer to this acquired protection against injury. Structural and conditional tolerance and accommodation overlap in such a way that potentially toxic products can be generated to control microorganisms and neutralize toxins without overly damaging adjacent cells. The central challenge in transplantation, then, should be the orchestration of structural and conditional tolerance and accommodation in such a way that toxic products can still be generated for defense while preserving graft function and survival. Since the earliest days of transplantation, immunobiologists have sought means by which to prevent recognition and rejection of foreign tissue. The goal of these strategies is the retention of recipient immune function while selectively avoiding graft injury. While considerable theoretical and technical problems remain, an analogous problem and solution already exists in nature. Here, we discuss the mechanisms by which organisms preclude or control auto-toxicity, and for each, consider the corollaries between prevention of auto-toxicity and graft rejection. Further study of these controls, including structural and conditional tolerance and accommodation, will offer insight into new therapies for allo- and xenotransplantation. PMID:19996920

The application of telemedicine in orthopedic surgery in singapore: a pilot study on a secure, mobile telehealth application and messaging platform.

PubMed

Daruwalla, Zubin Jimmy; Wong, Keng Lin; Thambiah, Joseph

2014-06-05

The application of telemedicine has been described for its use in medical training and education, management of stroke patients, urologic surgeries, pediatric laparoscopic surgeries, clinical outreach, and the field of orthopedics. However, the usefulness of a secure, mobile telehealth application, and messaging platform has not been well described. A pilot study was conducted to implement a health insurance portability and accountability act (HIPAA) compliant form of communication between doctors in an orthopedic clinical setting and determine their reactions to MyDoc, a secure, mobile telehealth application, and messaging platform. By replacing current methods of communication through various mobile applications and text messaging services with MyDoc over a six week period, we gained feedback and determined user satisfaction with this innovative system from questionnaires handed to the program director, program coordinator, one trauma consultant, all orthopedic residents, and six non-orthopedic residents at the National University Hospital in Singapore. Almost everyone who completed the questionnaire strongly agreed that MyDoc should replace current systems of peer to peer communication in the hospital. The majority also felt that the quality of images, videos, and sound were excellent. Almost everyone agreed that they could communicate easily with each other and would feel comfortable doing so routinely. The majority felt that virtual consults through MyDoc should be made available to inpatients as well as outpatients to potentially lessen clinic loads and provide a secure manner in which patients can communicate with their primary teams any time convenient to both. It was also agreed by most that the potential of telerounding had advantages, especially on weekends as a supplement to normal rounds. Potential uses of MyDoc in an orthopedic clinical setting include HIPAA-compliant peer to peer communication, clinical outreach in the setting of trauma, supervision in the operating room or watching procedures being performed remotely, providing both patient and parent reassurance in pediatric orthopedic patients, and finally in the setting of outpatient clinics. With our pilot study having excellent results in terms of acceptance and satisfaction, the integration of a secure, mobile telehealth application, and messaging platform, not only in the orthopedic department but also the hospital in general, has an exciting and limitless potential. More so in this era where downsizing hospital costs is beneficial, doing so may also be mandatory in order to comply with the soon to be introduced personal data protection act.

Methods for evaluating potential sources of chloride in surface waters and groundwaters of the conterminous United States

USGS Publications Warehouse

Granato, Gregory E.; DeSimone, Leslie A.; Barbaro, Jeffrey R.; Jeznach, Lillian C.

2015-09-04

Scientists, engineers, regulators, and decisionmakers need information about potential sources of chloride, water and solute budgets, and methods for collecting water-quality data to help identify potential sources. This information is needed to evaluate potential sources of chloride in areas where chloride may have adverse ecological effects or may degrade water supplies used for drinking water, agriculture, or industry. Knowledge of potential sources will help decisionmakers identify the best mitigation measures to reduce the total background chloride load, thereby reducing the potential for water-quality exceedances that occur because of superposition on rising background concentrations. Also, knowledge of potential sources may help decisionmakers identify the potential for the presence of contaminants that have toxic, carcinogenic, mutagenic, or endocrine-disrupting effects at concentrations that are lower by orders of magnitude than the chloride concentrations in the source water. This report is a comprehensive synthesis of relevant information, but it is not the result of an exhaustive search for literature on each topic. The potential adverse effects of chloride on infrastructure and the environment are not discussed in this report because these issues have been extensively documented elsewhere.

Physics-Driven Innovation In the Oil and Gas Industry

NASA Astrophysics Data System (ADS)

Poitzsch, Martin

2014-03-01

In terms of sheer scale and financial investment and geographical footprint, nothing is bigger than the oil and gas industry. This ``mature industry'' employs a bewildering mix of technologies dating from the 19th century to the 21th. Oil well construction represents one of the largest volume markets for steel tubulars, Portland cement, and high-quality sand. On the other hand, advanced 3D seismic data processing, shaped-charge perforating, and nuclear well logging have consistently driven forward the state of the art in their respective areas of applied science, as much or more so than defense or other industries. Moreover, a surprising number of physicists have made their careers in the oil industry. To succeed at introducing new technology requires understanding which problems most need to be solved. The most esoteric technology can take off in this industry if it honestly offers the best solution to a key problem that is costing millions of dollars in risk or inefficiency. When the right breakthrough solution emerges, the resources to implement it can be almost limitless. However, the prevailing culture is conservative and brutally cost-driven: any cheaper or simpler solution that performs as well will prevail, no matter how inelegant!

Tea and its consumption: benefits and risks.

PubMed

Hayat, Khizar; Iqbal, Hira; Malik, Uzma; Bilal, Uzma; Mushtaq, Sobia

2015-01-01

The recent convention of introducing phytochemicals to support the immune system or combat diseases is a centuries' old tradition. Nutritional support is an emerging advancement in the domain of diet-based therapies; tea and its constituents are one of the significant components of these strategies to maintain the health and reduce the risk of various malignancies. Tea is the most frequently consumed beverage worldwide, besides water. All the three most popular types of tea, green (unfermented), black (fully fermented), and oolong (semifermented), are manufactured from the leaves of the plant Camellia sinensis. Tea possesses significant antioxidative, anti-inflammatory, antimicrobial, anticarcinogenic, antihypertensive, neuroprotective, cholesterol-lowering, and thermogenic properties. Several research investigations, epidemiological studies, and meta-analyses suggest that tea and its bioactive polyphenolic constituents have numerous beneficial effects on health, including the prevention of many diseases, such as cancer, diabetes, arthritis, cardiovascular disease (CVD), stroke, genital warts, and obesity. Controversies regarding beneficialts and risks of tea consumption still exist but the limitless health-promoting benefits of tea outclass its few reported toxic effects. However, with significant rise in the scientific investigation of role of tea in human life, this review is intended to highlight the beneficial effects and risks associated with tea consumption.

Microstructural Evolution in Friction Stir Welding of Ti-6Al-4V

NASA Technical Reports Server (NTRS)

Rubisoff, H.; Querin, J.; Magee, D.; Schneider, J.

2008-01-01

Friction stir welding (FSW) is a thermo-mechanical process that utilizes a nonconsumable rotating pin tool to consolidate a weld joint. In the conventional FSW process, the pin tool is responsible for generating both the heat required to soften the material and the forces necessary to deform and combine the weld seam. As such, the geometry of the pin tool is important to the quality of the weld and the process parameters required to produce the weld. Because the geometry of the pin tool is limitless, a reduced set of pin tools was formed to systematically study their effect on the weldment with respect to mechanical properties and resultant microstructure. In this study 0deg, 15deg, 30deg, 45deg, and 60deg tapered, microwave sintered, tungsten carbide (WC) pin tools were used to FSW Ti-6Al-4V. Transverse sections of the weld were used to test for mechanical properties and to document the microstructure using optical microscopy. X-ray diffraction (XRD) was also used to characterize the microstructure in the welds. FSW results for the 45deg and 60deg pin tools are reported in this paper.

Contributions of 3D Cell Cultures for Cancer Research.

PubMed

Ravi, Maddaly; Ramesh, Aarthi; Pattabhi, Aishwarya

2017-10-01

Cancer cell lines have contributed immensely in understanding the complex physiology of cancers. They are excellent material for studies as they offer homogenous samples without individual variations and can be utilised with ease and flexibility. Also, the number of assays and end-points one can study is almost limitless; with the advantage of improvising, modifying or altering several variables and methods. Literally, a new dimension to cancer research has been achieved by the advent of 3Dimensional (3D) cell culture techniques. This approach increased many folds the ways in which cancer cell lines can be utilised for understanding complex cancer biology. 3D cell culture techniques are now the preferred way of using cancer cell lines to bridge the gap between the 'absolute in vitro' and 'true in vivo'. The aspects of cancer biology that 3D cell culture systems have contributed include morphology, microenvironment, gene and protein expression, invasion/migration/metastasis, angiogenesis, tumour metabolism and drug discovery, testing chemotherapeutic agents, adaptive responses and cancer stem cells. We present here, a comprehensive review on the applications of 3D cell culture systems for these aspects of cancers. J. Cell. Physiol. 232: 2679-2697, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

A BRIEF HISTORY OF CLINICAL XENOTRANSPLANTATION

PubMed Central

Cooper, David K. C.; Ekser, Burcin; Tector, A. Joseph

2015-01-01

Between the 17th and 20th centuries, blood was transfused from various animal species into patients with a variety of pathological conditions. Skin grafts were carried out in the 19th century, with grafts from a variety of animals, with frogs being the most popular. In the 1920s, Voronoff advocated the transplantation of slices of chimpanzee testis into elderly men, believing that the hormones produced by the testis would rejuvenate his patients. In 1963–4, when human organs were not available and dialysis was not yet in use, Reemtsma transplanted chimpanzee kidneys into 13 patients, one of whom returned to work for almost 9 months before suddenly dying from what was believed to be an electrolyte disturbance. The first heart transplant in a human ever performed was by Hardy in 1964, using a chimpanzee heart, but the patient died within two hours. Starzl carried out the first chimpanzee-to-human liver transplantation in 1966; in 1992 he obtained patient survival for 70 days following a baboon liver transplant. The first clinical pig islet transplant was carried out by Groth in 1993. Today, genetically-modified pigs offer hope of a limitless supply of organs and cells for those in need of a transplant. PMID:26118617

Secure message authentication system for node to node network

NASA Astrophysics Data System (ADS)

Sindhu, R.; Vanitha, M. M.; Norman, J.

2017-10-01

The Message verification remains some of the best actual methods for prevent the illegal and dis honored communication after presence progressed to WSNs (Wireless Sensor Networks). Intend for this purpose, several message verification systems must stand established, created on both symmetric key cryptography otherwise public key cryptosystems. Best of them will have some limits for great computational then statement above in count of deficiency of climb ability then flexibility in node settlement occurrence. In a polynomial based system was newly presented for these problems. Though, this system then situations delay will must the dimness of integral limitation firm in the point of polynomial: once the amount of message transferred remains the greater than the limitation then the opponent will completely improve the polynomial approaches. This paper suggests using ECC (Elliptic Curve Cryptography). Though using the node verification the technique in this paper permits some nodes to transfer a limitless amount of messages lacking misery in the limit problem. This system will have the message cause secrecy. Equally theoretic study then model effects show our planned system will be effective than the polynomial based method in positions of calculation then statement above in privacy points though message basis privacy.

Colonizing the Plutoids: The Key to Human Expansion into the Galaxy

NASA Astrophysics Data System (ADS)

Roy, K. I.; Kennedy, R. G.; Fields, D. E.

Pluto-type worlds (plutoids) are far more numerous in our solar system than initially thought with hundreds, maybe thousands, of them existing in the Kuiper belt and Oort cloud. Other stars are likely to also possess many such worlds. These worlds possess almost limitless quantities of water and substantial quantities of nitrogen, which are two limiting ingredients necessary for terraforming planets in the inner solar system. Assuming that faster-than-light travel is impractical, that artificial gravity is only possible via circular motion, that humans remain basically unchanged, and that humanity's expansion into the solar system and beyond is desirable, then exploiting the resources of, and establishing bases and even colonies on, icy plutoids may become essential for human expansion into space. Such colonies face problems involving gravity, radiation, energy supply and complex ecologies. This paper attempts to address those issues and outline what such colonies might look like. This type of colony offers humanity, and perhaps other species, the ability to establish settlements at otherwise undesirable locations, including red and brown dwarf stars. Such colonies could even be established in orphan planets in interstellar space, far from any star.

Towards a global initiative for fibrosis treatment (GIFT)

PubMed Central

Agusti, Alvar; Crestani, Bruno; Schwartz, David A.; Chambers, Rachel C.; Maher, Toby M.; Faner, Rosa; Mora, Ana Lucia; Rojas, Mauricio; Antoniou, Katerina M.; Sellares, Jacobo

2017-01-01

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterised by increased scarring of lung tissue. Despite the recent introduction of novel drugs that slow disease progression, IPF remains a deadly disease, and the benefits of these new drugs differ markedly between patients. Human diseases arise due to alterations in an almost limitless network of interconnected genes, proteins, metabolites, cells and tissues, in direct relationship with a continuously changing macro- or microenvironment. Systems biology is a novel research strategy that seeks to understand the structure and behaviour of the so-called “emergent properties” of complex systems, such as those involved in disease pathogenesis, which are most often overlooked when just one element of disease pathogenesis is observed in isolation. This article summarises the debate that took place during a European Respiratory Society research seminar in Barcelona, Spain on December 15–16, 2016, which focused on how systems biology could generate new data by integrating the different IPF pathogenic levels of complexity. The main conclusion of the seminar was to create a global initiative to improve IPF outcomes by integrating cutting-edge international research that leverages systems biology to develop a precision medicine approach to tackle this devastating disease. PMID:29214157

Development of a functionalized UV-emitting nanocomposite for the treatment of cancer using indirect photodynamic therapy.

PubMed

Sengar, Prakhar; Juárez, Patricia; Verdugo-Meza, Andrea; Arellano, Danna L; Jain, Akhil; Chauhan, Kanchan; Hirata, Gustavo A; Fournier, Pierrick G J

2018-02-27

Photodynamic therapy is a promising cancer therapy modality but its application for deep-seated tumor is mainly hindered by the shallow penetration of visible light. X-ray-mediated photodynamic therapy (PDT) has gained a major attention owing to the limitless penetration of X-rays. However, substantial outcomes have still not been achieved due to the low luminescence efficiency of scintillating nanoparticles and weak energy transfer to the photosensitizer. The present work describes the development of Y 2.99 Pr 0.01 Al 5 O 12 -based (YP) mesoporous silica coated nanoparticles, multifunctionalized with protoporphyrin IX (PpIX) and folic acid (YPMS@PpIX@FA) for potential application in targeted deep PDT. A YP nanophosphor core was synthesized using the sol-gel method to be used as X-ray energy transducer and was then covered with a mesoporous silica layer. The luminescence analysis indicated a good spectral overlap between the PpIX and nanoscintillator at the Soret as well as Q-band region. The comparison of the emission spectra with or without PpIX showed signs of energy transfer, a prerequisite for deep PDT. In vitro studies showed the preferential uptake of the nanocomposite in cancer cells expressing the folate receptorFolr1, validating the targeting efficiency. Direct activation of conjugated PpIX with UVA in vitro induced ROS production causing breast and prostate cancer cell death indicating that the PpIX retained its activity after conjugation to the nanocomposite. The in vivo toxicity analysis showed the good biocompatibility and non-immunogenic response of YPMS@PpIX@FA. Our results indicate that YPMS@PpIX@FA nanocomposites are promising candidates for X-ray-mediated PDT of deep-seated tumors. The design of these nanoparticles allows the functionalization with exchangeable targeting ligands thus offering versatility, in order to target various cancer cells, expressing different molecular targets on their surface.

Processing of Space Resources to Enable the Vision for Space Exploration

NASA Technical Reports Server (NTRS)

Curreri, Peter A.

2006-01-01

The NASA human exploration program as directed by the Vision for Exploration (G.W. Bush, Jan. 14,2004) includes developing methods to process materials on the Moon and beyond to enable safe and affordable human exploration. Processing space resources was first popularized (O Neill 1976) as a technically viable, economically feasible means to build city sized habitats and multi GWatt solar power satellites in Earth/Moon space. Although NASA studies found the concepts to be technically reasonable in the post Apollo era (AMES 1979), the front end costs the limits of national or corporate investment. In the last decade analysis of space on has shown it to be economically justifiable even on a relatively small mission or commercial scenario basis. The Mars Reference Mission analysis (JSC 1997) demonstrated that production of return propellant on Mars can enable an order of magnitude decrease in the costs of human Mars missions. Analysis (by M. Duke 2003) shows that production of propellant on the Moon for the Earth based satellite industries can be commercially viable after a human lunar base is established. Similar economic analysis (Rapp 2005) also shows large cost benefits for lunar propellant production for Mars missions and for the use of lunar materials for the production of photovoltaic power (Freundlich 2005). Recent technologies could enable much smaller initial costs, to achieve mass, energy, and life support self sufficiency, than were achievable in the 1970s. If the Exploration Vision program is executed with a front end emphasis on space resources, it could provide a path for human self reliance beyond Earth orbit. This path can lead to an open, non-zero-sum, future for humanity with safer human competition with limitless growth potential. This paper discusses extension of the analysis for space resource utilization, to determine the minimum systems necessary for human self sufficiency and growth off Earth. Such a approach can provide a more compelling and comprehensive path to space resource utilization.

Using Complex Event Processing (CEP) and vocal synthesis techniques to improve comprehension of sonified human-centric data

NASA Astrophysics Data System (ADS)

Rimland, Jeff; Ballora, Mark

2014-05-01

The field of sonification, which uses auditory presentation of data to replace or augment visualization techniques, is gaining popularity and acceptance for analysis of "big data" and for assisting analysts who are unable to utilize traditional visual approaches due to either: 1) visual overload caused by existing displays; 2) concurrent need to perform critical visually intensive tasks (e.g. operating a vehicle or performing a medical procedure); or 3) visual impairment due to either temporary environmental factors (e.g. dense smoke) or biological causes. Sonification tools typically map data values to sound attributes such as pitch, volume, and localization to enable them to be interpreted via human listening. In more complex problems, the challenge is in creating multi-dimensional sonifications that are both compelling and listenable, and that have enough discrete features that can be modulated in ways that allow meaningful discrimination by a listener. We propose a solution to this problem that incorporates Complex Event Processing (CEP) with speech synthesis. Some of the more promising sonifications to date use speech synthesis, which is an "instrument" that is amenable to extended listening, and can also provide a great deal of subtle nuance. These vocal nuances, which can represent a nearly limitless number of expressive meanings (via a combination of pitch, inflection, volume, and other acoustic factors), are the basis of our daily communications, and thus have the potential to engage the innate human understanding of these sounds. Additionally, recent advances in CEP have facilitated the extraction of multi-level hierarchies of information, which is necessary to bridge the gap between raw data and this type of vocal synthesis. We therefore propose that CEP-enabled sonifications based on the sound of human utterances could be considered the next logical step in human-centric "big data" compression and transmission.

Oxidant production from source-oriented particulate matter - Part 1: Oxidative potential using the dithiothreitol (DTT) assay

NASA Astrophysics Data System (ADS)

Charrier, J. G.; Richards-Henderson, N. K.; Bein, K. J.; McFall, A. S.; Wexler, A. S.; Anastasio, C.

2014-09-01

Recent epidemiological evidence supports the hypothesis that health effects from inhalation of ambient particulate matter (PM) are governed by more than just the mass of PM inhaled. Both specific chemical components and sources have been identified as important contributors to mortality and hospital admissions, even when these endpoints are unrelated to PM mass. Sources may cause adverse health effects via their ability to produce reactive oxygen species, possibly due to the transition metal content of the PM. Our goal is to quantify the oxidative potential of ambient particle sources collected during two seasons in Fresno, CA using the dithiothreitol (DTT) assay. We collected PM from different sources or source combinations into different ChemVol (CV) samplers in real time using a novel source-oriented sampling technique based on single particle mass spectrometry. We segregated the particles from each source-oriented mixture into two size fractions - ultrafine (Dp ≤ 0.17 μm) and submicron fine (0.17 μm ≤ Dp ≤ 1.0 μm) - and measured metals and the rate of DTT loss in each PM extract. We find that the mass-normalized oxidative potential of different sources varies by up to a actor of 8 and that submicron fine PM typically has a larger mass-normalized oxidative potential than ultrafine PM from the same source. Vehicular Emissions, Regional Source Mix, Commute Hours, Daytime Mixed Layer and Nighttime Inversion sources exhibit the highest mass-normalized oxidative potential. When we apportion the volume-normalized oxidative potential, which also accounts for the source's prevalence, cooking sources account for 18-29% of the total DTT loss while mobile (traffic) sources account for 16-28%. When we apportion DTT activity for total PM sampled to specific chemical compounds, soluble copper accounts for roughly 50% of total air-volume-normalized oxidative potential, soluble manganese accounts for 20%, and other unknown species, likely including quinones and other organics, account for 30%. During nighttime, soluble copper and manganese largely explain the oxidative potential of PM, while daytime has a larger contribution from unknown (likely organic) species.

Increasing the dynamic range of CMOS photodiode imagers

NASA Technical Reports Server (NTRS)

Pain, Bedabrata (Inventor); Cunningham, Thomas J. (Inventor); Hancock, Bruce R. (Inventor)

2007-01-01

A multiple-step reset process and circuit for resetting a voltage stored on a photodiode of an imaging device. A first stage of the reset occurs while a source and a drain of a pixel source-follower transistor are held at ground potential and the photodiode and a gate of the pixel source-follower transistor are charged to an initial reset voltage having potential less that of a supply voltage. A second stage of the reset occurs after the initial reset voltage is stored on the photodiode and the gate of the pixel source-follower transistor and the source and drain voltages of the pixel source-follower transistor are released from ground potential thereby allowing the source and drain voltages of the pixel source-follower transistor to assume ordinary values above ground potential and resulting in a capacitive feed-through effect that increases the voltage on the photodiode to a value greater than the initial reset voltage.

46 CFR 112.30-10 - Restoration of normal source potential.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Section 112.30-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING EMERGENCY LIGHTING AND POWER SYSTEMS Emergency Systems Having an Automatically Connected Storage Battery as the Sole Emergency Power Source § 112.30-10 Restoration of normal source potential. When the potential...

46 CFR 112.30-10 - Restoration of normal source potential.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Section 112.30-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING EMERGENCY LIGHTING AND POWER SYSTEMS Emergency Systems Having an Automatically Connected Storage Battery as the Sole Emergency Power Source § 112.30-10 Restoration of normal source potential. When the potential...

46 CFR 112.30-10 - Restoration of normal source potential.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Section 112.30-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING EMERGENCY LIGHTING AND POWER SYSTEMS Emergency Systems Having an Automatically Connected Storage Battery as the Sole Emergency Power Source § 112.30-10 Restoration of normal source potential. When the potential...

46 CFR 112.30-10 - Restoration of normal source potential.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Section 112.30-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING EMERGENCY LIGHTING AND POWER SYSTEMS Emergency Systems Having an Automatically Connected Storage Battery as the Sole Emergency Power Source § 112.30-10 Restoration of normal source potential. When the potential...

46 CFR 112.30-10 - Restoration of normal source potential.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Section 112.30-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING EMERGENCY LIGHTING AND POWER SYSTEMS Emergency Systems Having an Automatically Connected Storage Battery as the Sole Emergency Power Source § 112.30-10 Restoration of normal source potential. When the potential...

Illicit drugs: contaminants in the environment and utility in forensic epidemiology.

PubMed

Daughton, Christian G

2011-01-01

The published literature that addresses the many facets of pharmaceutical ingredients as environmental contaminants has grown exponentially since the 1990s. Although there are several thousand active ingredients used in medical pharmaceuticals worldwide, illicit drug ingredients (IDIs) have generally been excluded from consideration. Medicinal and illicit drugs have been treated separately in environmental research even though they pose many of the same concerns regarding the potential for both human and ecological exposure. The overview presented here covers the state of knowledge up until mid-2010 regarding the origin, occurrence, fate, and potential for biological effects of IDIs in the environment. Similarities exist with medical pharmaceuticals, particularly with regard to the basic processes by which these ingredients enter the environment--excretion of unmetabolized residues (including via sweat), bathing, disposal, and manufacturing. The features of illicit drugs that distinguish them from medical pharmaceuticals are discussed. Demarcations between the two are not always clear, and a certain degree of overlap adds additional confusion as to what exactly defines an illicit drug; indeed, medical pharmaceuticals diverted from the legal market or used for non-medicinal purposes ar also captured in discussions of illicit drugs. Also needing consideration as par tof the universe of IDIs are the numerous adulterants and synthesis impurities often encountered in these very impure preparations. many of these extraneous chemicals have high biological activity themselves. In contract to medical pharmaceuticals, comparatively little is know about the fate and effects of IDIs in the environment. Environmental surveys for IDIs have revealed their presence in sewage wastewaters, raw sewage sludge and processed sludge (biosolids), and drinking water. Nearly nothing is known, however, regarding wildlife exposure to IDIs, especially aquatic exposure such as indicated by bioconcentration i tissues. In contrast to pharmaceuticals, chemical monitoring surveys have revealed the presence of certain IDIs in air and monetary currencies--the latter being of interest for the forensic tracking of money used in drug trafficking. Another unknown with regard to IDIs is the accuracy of current knowledge regarding the complete scope of chemical identities of the numerous types of IDIs in actual use (particularly some of the continually evolving designer drugs new to forensic chemistry) as well as the total quantities being trafficked, consumed, or disposed. The major aspect unique to the study of IDI's in the environment is making use of their presence in the environment as a tool to obtain better estimates of the collective usage of illicit drugs across entire communities. First proposed in 2001, but under investigation with field applications only since 2005, this new modeling approach for estimating drug usage by monitoring the concentrations of IDIs (or certain unique metabolites) in untreated sewage has potential as an additional source of data to augment or corroborate the information-collection ability of conventional written and oral surveys of drug-user populations. This still evolving monitoring tool has been called "sewer epidemiology" but is referred to in this chapter by a more descriptive proposed term "FEUDS" (Forensic Epidemiology Using Drugs in Sewage). The major limitation of FEUDS surrounds the variables involved at various steps performed in FEUDS calculations. These variables are summarized and span sampling and chemical analysis to the final numeric calculations, which particularly require a better understanding of IDI pharmacokinetics than currently exists. Although little examined in the literature, the potential for abuse of FEUDS as a tool in law enforcement is briefly discussed. Finally, the growing interest in FEUDS as a methodological approach for estimating collective public usage of illicit drugs points to the feasibility of mining other types of chemical information from sewage. On the horizon is the potential for "sewage information mining" (SIM) as a general approach for measuring a nearly limitless array of biochemical markers that could serve as collective indicators of the specific or general status of public health or disease at the community-wide level. SIM may create the opportunity to view communities from a new perspective--"communities as the patient." This could potentially lead to the paradigm of combining human and ecological communities as a single patient--as an interconnected whole.

Oxidant production from source-oriented particulate matter - Part 1: Oxidative potential using the dithiothreitol (DTT) assay

NASA Astrophysics Data System (ADS)

Charrier, J. G.; Richards-Henderson, N. K.; Bein, K. J.; McFall, A. S.; Wexler, A. S.; Anastasio, C.

2015-03-01

Recent epidemiological evidence supports the hypothesis that health effects from inhalation of ambient particulate matter (PM) are governed by more than just the mass of PM inhaled. Both specific chemical components and sources have been identified as important contributors to mortality and hospital admissions, even when these end points are unrelated to PM mass. Sources may cause adverse health effects via their ability to produce reactive oxygen species in the body, possibly due to the transition metal content of the PM. Our goal is to quantify the oxidative potential of ambient particle sources collected during two seasons in Fresno, CA, using the dithiothreitol (DTT) assay. We collected PM from different sources or source combinations into different ChemVol (CV) samplers in real time using a novel source-oriented sampling technique based on single-particle mass spectrometry. We segregated the particles from each source-oriented mixture into two size fractions - ultrafine Dp ≤ 0.17 μm) and submicron fine (0.17 μm ≤ Dp ≤ 1.0 μm) - and measured metals and the rate of DTT loss in each PM extract. We find that the mass-normalized oxidative potential of different sources varies by up to a factor of 8 and that submicron fine PM typically has a larger mass-normalized oxidative potential than ultrafine PM from the same source. Vehicular emissions, regional source mix, commute hours, daytime mixed layer, and nighttime inversion sources exhibit the highest mass-normalized oxidative potential. When we apportion DTT activity for total PM sampled to specific chemical compounds, soluble copper accounts for roughly 50% of total air-volume-normalized oxidative potential, soluble manganese accounts for 20%, and other unknown species, likely including quinones and other organics, account for 30%. During nighttime, soluble copper and manganese largely explain the oxidative potential of PM, while daytime has a larger contribution from unknown (likely organic) species.

The feasibility of effluent trading in the oil and gas industry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Veil, J.A.

1997-09-01

In January 1996, the U.S. Environmental Protection Agency (EPA) released a policy statement endorsing wastewater effluent trading in watersheds, hoping to promote additional interest in the subject. The policy describes five types of effluent trades - point source/point source, point source/nonpoint source, pretreatment, intraplant, and nonpoint source/nonpoint source. This paper evaluates the feasibility of effluent trading for facilities in the oil and gas industry. The evaluation leads to the conclusion that potential for effluent trading is very low in the exploration and production and distribution and marketing sectors; trading potential is moderate for the refining sector except for intraplant trades,more » for which the potential is high. Good potential also exists for other types of water-related trades that do not directly involve effluents (e.g., wetlands mitigation banking). The potential for effluent trading in the energy industries and in other sectors would be enhanced if Congress amended the Clean Water Act (CWA) to formally authorize such trading.« less

From Google Maps to Google Models (Invited)

NASA Astrophysics Data System (ADS)

Moore, R. V.

2010-12-01

Why hasn’t integrated modelling taken off? To its advocates, it is self-evidently the best and arguably the only tool available for understanding and predicting the likely response of the environment to events and policies. Legislation requires managers to ensure that their plans are sustainable. How, other than by modelling the interacting processes involved, can the option with the greatest benefits be identified? Integrated modelling (IM) is seen to have huge potential. In science, IM is used to extend and encapsulate our understanding of the whole earth system. Such models are beginning to be incorporated in operational decision support systems and used to seek sustainable solutions to society’s problems, but only on a limited scale. Commercial take up is negligible yet the opportunities would appear limitless. The need is there; the potential is there, so what is inhibiting IM’s take up? What must be done to reap the rewards of the R & D to date? To answer the question, it useful to look back at the developments which have seen paper maps evolve into Google Maps and the systems that now surround it; facilities available not just to experts and governments but to anyone with a an iphone and an internet connection. The initial objective was to automate the process of drawing lines on paper, though it was quickly realised that digitising maps was the key to unlocking the information they held. However, it took thousands of PhD and MSc projects before a computer could generate a map comparable to that produced by a cartographer and many more before it was possible to extract reliable useful information from maps. It also required advances in IT and a change of mindset from one focused on paper map production to one focused on information delivery. To move from digital maps to Google Maps required the availability of data on a world scale, the resources to bring them together, the development of remote sensing, satellite navigation and communications technology and the creation of a commercial climate and conditions that allowed businesses anywhere to exploit the new information. This talk will draw lessons from the experience and imagine how Google Maps could become Google Models. The first lesson is time scale, it took far longer for digital mapping to move out of the development phase than most expected. Its first real customers were the public utilities. They are large organisations, risk averse and take time to change their ways of working; integrated modellers should not be surprised by the slow take up. Few of the early commercial entrants made any significant profits. It was only when the data reached critical mass and became accessible, when the systems became easy to use, affordable and accessible via the web, when convincing demonstrations became available and the necessary standards emerged that Google Maps could emerge. IM has yet to reach this point. It has far bigger technical, scientific and institutional challenges to overcome. The resources required will be large. It is possible though that they could be marshalled by creating an open source community of practice. However, that community will need a facilitating core group and standards to succeed. Having seen what Google Maps made possible, the innovative ideas it released, it is not difficult to imagine where a community of practice might take IM.

Using smart card technology to monitor the eating habits of children in a school cafeteria: 2. The nutrient contents of all meals chosen by a group of 8- to 11-year-old boys over 78 days.

PubMed

Lambert, N; Plumb, J; Looise, B; Johnson, I T; Harvey, I; Wheeler, C; Robinson, M; Rolfe, P

2005-08-01

The aim of the study was to test the abilities of the newly created smart card system to track the nutrient contents of foods chosen over several months by individual diners in a school cafeteria. From the food choice and composition of food data sets, an Access database was created encompassing 30 diners (aged 8-11 years), 78 days and eight nutrients. Data were available for a total of 1909 meals. Based upon population mean values the cohort were clearly choosing meals containing higher than the recommended maximum amounts for sugar and lower than the recommended minimum amounts of fibre, iron and vitamin A. Protein and vitamin C contents of meals chosen were well above minimum requirements. Over the 1909 meals, nutrient requirements were met 41% of the time. The system created was very effective at continually monitoring food choices of individual diners over limitless time. The data generated raised questions on the common practice of presenting nutrient intakes as population mean values calculated over a few days. The impact of heavily fortified foods on such studies in general is discussed.

Development of risk-based nanomaterial groups for occupational exposure control

NASA Astrophysics Data System (ADS)

Kuempel, E. D.; Castranova, V.; Geraci, C. L.; Schulte, P. A.

2012-09-01

Given the almost limitless variety of nanomaterials, it will be virtually impossible to assess the possible occupational health hazard of each nanomaterial individually. The development of science-based hazard and risk categories for nanomaterials is needed for decision-making about exposure control practices in the workplace. A possible strategy would be to select representative (benchmark) materials from various mode of action (MOA) classes, evaluate the hazard and develop risk estimates, and then apply a systematic comparison of new nanomaterials with the benchmark materials in the same MOA class. Poorly soluble particles are used here as an example to illustrate quantitative risk assessment methods for possible benchmark particles and occupational exposure control groups, given mode of action and relative toxicity. Linking such benchmark particles to specific exposure control bands would facilitate the translation of health hazard and quantitative risk information to the development of effective exposure control practices in the workplace. A key challenge is obtaining sufficient dose-response data, based on standard testing, to systematically evaluate the nanomaterials' physical-chemical factors influencing their biological activity. Categorization processes involve both science-based analyses and default assumptions in the absence of substance-specific information. Utilizing data and information from related materials may facilitate initial determinations of exposure control systems for nanomaterials.

NASA 2nd Generation RLV Program Introduction, Status and Future Plans

NASA Technical Reports Server (NTRS)

Dumbacher, Dan L.; Smith, Dennis E. (Technical Monitor)

2002-01-01

The Space Launch Initiative (SLI), managed by the Second Generation Reusable Launch Vehicle (2ndGen RLV) Program, was established to examine the possibility of revolutionizing space launch capabilities, define conceptual architectures, and concurrently identify the advanced technologies required to support a next-generation system. Initial Program funds have been allocated to design, evaluate, and formulate realistic plans leading to a 2nd Gen RLV full-scale development (FSD) decision by 2006. Program goals are to reduce both risk and cost for accessing the limitless opportunities afforded outside Earth's atmosphere fo civil, defense, and commercial enterprises. A 2nd Gen RLV architecture includes a reusable Earth-to-orbit launch vehicle, an on-orbit transport and return vehicle, ground and flight operations, mission planning, and both on-orbit and on-the-ground support infrastructures All segments of the architecture must advance in step with development of the RLV if a next-generation system is to be fully operational early next decade. However, experience shows that propulsion is the single largest contributor to unreliability during ascent, requires the largest expenditure of time for maintenance, and takes a long time to develop; therefore, propulsion is the key to meeting safety, reliability, and cost goals. For these reasons, propulsion is SLI's top technology investment area.

[Education in our time: competency or aptitude? The case for medicine. Part I].

PubMed

Viniegra-Velázquez, Leonardo

This paper begins with a statement: It is necessary to characterize the respective society to be able to understand the education's core. Distinctive features of the present-day world lead us to define it as the ruin of a civilization based on limitless financial gain, where education has a passive quality, responsible of maintaining the status quo as well as preserving the degrading attributes of actual societies: individualism, passivity, competitiveness, consumerism and high vulnerability to control and manipulation. About the dilemma: competency or aptitude, these are not synonyms but concepts pertaining radically different approaches to the practice and understanding of education. Competency represents the actual tendencies of passive education, where knowledge is just about acquiring information. Aptitude refers to participatory education, described in the second part of this essay. The passive education is present in the professional competencies model, specified in terms of curricula, profiles, levels, school activities, evaluation, concept of progress and social consequences. This paradigm does not foster real progress-defined as the primacy of values sustaining spiritual, intellectual and moral development but as an "accomplice" of the civilization's collapse. Copyright © 2017 Hospital Infantil de México Federico Gómez. Publicado por Masson Doyma México S.A. All rights reserved.

A brief history of clinical xenotransplantation.

PubMed

Cooper, David K C; Ekser, Burcin; Tector, A Joseph

2015-11-01

Between the 17th and 20th centuries, blood was transfused from various animal species into patients with a variety of pathological conditions. Skin grafts were carried out in the 19th century, with grafts from a variety of animals, with frogs being the most popular. In the 1920s, Voronoff advocated the transplantation of slices of chimpanzee testis into elderly men, believing that the hormones produced by the testis would rejuvenate his patients. In 1963-4, when human organs were not available and dialysis was not yet in use, Reemtsma transplanted chimpanzee kidneys into 13 patients, one of whom returned to work for almost 9 months before suddenly dying from what was believed to be an electrolyte disturbance. The first heart transplant in a human ever performed was by Hardy in 1964, using a chimpanzee heart, but the patient died within 2 h. Starzl carried out the first chimpanzee-to-human liver transplantation in 1966; in 1992 he obtained patient survival for 70 days following a baboon liver transplant. The first clinical pig islet transplant was carried out by Groth in 1993. Today, genetically-modified pigs offer hope of a limitless supply of organs and cells for those in need of a transplant. Copyright © 2015 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved.

Patient and family involvement in contemporary health care.

PubMed

Angood, Peter; Dingman, Jennifer; Foley, Mary E; Ford, Dan; Martins, Becky; O'Regan, Patti; Salamendra, Arlene; Sheridan, Sue; Denham, Charles R

2010-03-01

The objective of this article was to provide a guide to health care providers on patient and family involvement in health care. This article evaluated the latest published studies for patient and family involvement and reexamined the objectives, the requirements for achieving these objectives, and the evidence of how to involve patients and families. Critical components for patient safety include changing the organizational culture; including patients and families on teams; listening to patients and families; incorporating their input into leadership structures and systems; providing full detail about treatment, procedures, and medication adverse effects; involving them on patient safety and performance improvement committees; and disclosing medical errors. The conclusion of this article is that, for the future, patient and family involvement starts with educating patients and families and ends with listening to them and taking them seriously. If patient and family input is emphatically built into systems of performance improvement, and if patients and families are taken seriously and are respected for their valuable perspectives about how care can be improved, then organizations can improve at improving. Resources in health care are in short supply, yet the resources of patient and family help and time are almost limitless, are ready to be tapped, and can have a huge impact on improving the reliability and overall success for any health care organization.

Destruction of Last Good Surface of The Simple Map For Single-null Divertor Tokamaks

NASA Astrophysics Data System (ADS)

Leach, Genese; Ali, Halima; Punjabi, Alkesh

2003-10-01

The Simple Map (SM) for a single-null diverted tokamak is given by x_n+1=x_n-ky_n(1-y_n) and y_n+1=y_n+kx_n+1, where the map parameter k represents the effects of toroidal asymmetries. Here we investigate what happens to the last good surface of SM with k= 0.6 when the value of k is increased. When k is in the region between .6 to .611, the good surface disappears and islands of different sizes and shapes start to appear. We find chaos when k is in the region between .6110 to 0.640. Some of these islands exhibit self-similarity. Self- Similarity can occur for a limitless number of times if one magnifies into this chaotic region. A Fortran code and TecPlot are used to visualize the data. Study of this phenomenon may contribute to the magnetic confinement problem through a better understanding of why and how the deterioration of the last good surface occurs. This work is jointly supported by NASA SHARP and US DOE Grant number DE-FG02-02ER54673. 1. Punjabi et al, Phys. Rev. Lett., 69, 3322 (1992), 2. Punjabi et al, Phys. Plasma, 4, 337 (1997)

The assemblage of compliance in psychiatric case management.

PubMed

Brodwin, Paul

2010-08-01

In the post-asylum era, case managers perform much of the face-to-face work of pharmaceutical compliance for people with severe and persistent mental illness. Their work demands careful orchestration of the assemblage of compliance, including the actual medications, the ideology of biopsychiatry, the division of professional labor, and certain mundane tools. Ethnographic vignettes from an Assertive Community Treatment (ACT) team show how case managers use this assemblage in their everyday routines, but also how it undercuts key elements of the original ACT mission. Reflecting its roots in the deinstitutionalization movement, the ACT model gives case managers limitless responsibilities for clients' lives, but then narrowly defines their role as the prosthetic extension of psychiatric authority. To produce compliance, case managers depend on the medication cassette, analyzed here as a human/non-human hybrid woven into their ordinary work. The medication cassette has pre-scripted uses that enlist clinicians in biopsychiatric thinking and also silently impose compliant behavior on clients. The elements in the assemblage of compliance depend on each other, but they do not form a seamless whole, as evidenced by the dilemmas and micropolitics of the clinical front-line. Theoretical notions of assemblages and technologies of compliance, drawn from science and technology studies, illuminate a core conundrum of practice in psychiatric case management.

ITER Fusion Energy

ScienceCinema

Holtkamp, Norbert

2018-01-09

ITER (in Latin “the way”) is designed to demonstrate the scientific and technological feasibility of fusion energy. Fusion is the process by which two light atomic nuclei combine to form a heavier over one and thus release energy. In the fusion process two isotopes of hydrogen – deuterium and tritium – fuse together to form a helium atom and a neutron. Thus fusion could provide large scale energy production without greenhouse effects; essentially limitless fuel would be available all over the world. The principal goals of ITER are to generate 500 megawatts of fusion power for periods of 300 to 500 seconds with a fusion power multiplication factor, Q, of at least 10. Q ? 10 (input power 50 MW / output power 500 MW). The ITER Organization was officially established in Cadarache, France, on 24 October 2007. The seven members engaged in the project – China, the European Union, India, Japan, Korea, Russia and the United States – represent more than half the world’s population. The costs for ITER are shared by the seven members. The cost for the construction will be approximately 5.5 billion Euros, a similar amount is foreseen for the twenty-year phase of operation and the subsequent decommissioning.

Understanding the electrical behavior of the action potential in terms of elementary electrical sources.

PubMed

Rodriguez-Falces, Javier

2015-03-01

A concept of major importance in human electrophysiology studies is the process by which activation of an excitable cell results in a rapid rise and fall of the electrical membrane potential, the so-called action potential. Hodgkin and Huxley proposed a model to explain the ionic mechanisms underlying the formation of action potentials. However, this model is unsuitably complex for teaching purposes. In addition, the Hodgkin and Huxley approach describes the shape of the action potential only in terms of ionic currents, i.e., it is unable to explain the electrical significance of the action potential or describe the electrical field arising from this source using basic concepts of electromagnetic theory. The goal of the present report was to propose a new model to describe the electrical behaviour of the action potential in terms of elementary electrical sources (in particular, dipoles). The efficacy of this model was tested through a closed-book written exam. The proposed model increased the ability of students to appreciate the distributed character of the action potential and also to recognize that this source spreads out along the fiber as function of space. In addition, the new approach allowed students to realize that the amplitude and sign of the extracellular electrical potential arising from the action potential are determined by the spatial derivative of this intracellular source. The proposed model, which incorporates intuitive graphical representations, has improved students' understanding of the electrical potentials generated by bioelectrical sources and has heightened their interest in bioelectricity. Copyright © 2015 The American Physiological Society.

Distinguishing dark matter from unresolved point sources in the Inner Galaxy with photon statistics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Samuel K.; Lisanti, Mariangela; Safdi, Benjamin R., E-mail: samuelkl@princeton.edu, E-mail: mlisanti@princeton.edu, E-mail: bsafdi@princeton.edu

2015-05-01

Data from the Fermi Large Area Telescope suggests that there is an extended excess of GeV gamma-ray photons in the Inner Galaxy. Identifying potential astrophysical sources that contribute to this excess is an important step in verifying whether the signal originates from annihilating dark matter. In this paper, we focus on the potential contribution of unresolved point sources, such as millisecond pulsars (MSPs). We propose that the statistics of the photons—in particular, the flux probability density function (PDF) of the photon counts below the point-source detection threshold—can potentially distinguish between the dark-matter and point-source interpretations. We calculate the flux PDFmore » via the method of generating functions for these two models of the excess. Working in the framework of Bayesian model comparison, we then demonstrate that the flux PDF can potentially provide evidence for an unresolved MSP-like point-source population.« less

Salt Power: Is Neptune's Ole Salt a Tiger in the Tank?

ERIC Educational Resources Information Center

Wick, Gerry Shishin

1979-01-01

Discussed is the utilization of salinity-gradient energy as a potential source of power. Detailed are the scientific principles, potential sources, latest research, and environmental effects associated with this alternative energy source. The future prospects are addressed. (BT)

40 CFR 35.4215 - What if my group can't find an adequate number of potential sources for a technical advisor or...

Code of Federal Regulations, 2010 CFR

2010-07-01

... number of potential sources for a technical advisor or other contractor? 35.4215 Section 35.4215... ASSISTANCE Grants for Technical Assistance Procuring A Technical Advisor Or Other Contractor with Tag Funds § 35.4215 What if my group can't find an adequate number of potential sources for a technical advisor...

Biogas Potential in the United States (Fact Sheet)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2013-10-01

Biogas has received increased attention as an alternative energy source in the United States. The factsheet provides information about the biogas (methane) potential from various sources in the country (by county and state) and estimates the power generation and transportation fuels production (renewable natural gas) potential from these biogas sources. It provides valuable information to the industry, academia and policy makers in support of their future decisions.

46 CFR 111.70-7 - Remote control, interlock, and indicator circuits.

Code of Federal Regulations, 2011 CFR

2011-10-01

... difference in potential between the external conductors, overcurrent protection need only be at the supply of... to start. (c) Source of potential. The potential for a control, interlock, or indicator circuit must... disconnected from all sources of potential by a disconnect device independent of the motor and controller...

46 CFR 111.70-7 - Remote control, interlock, and indicator circuits.

Code of Federal Regulations, 2014 CFR

2014-10-01

... difference in potential between the external conductors, overcurrent protection need only be at the supply of... to start. (c) Source of potential. The potential for a control, interlock, or indicator circuit must... disconnected from all sources of potential by a disconnect device independent of the motor and controller...

46 CFR 111.70-7 - Remote control, interlock, and indicator circuits.

Code of Federal Regulations, 2013 CFR

2013-10-01

... difference in potential between the external conductors, overcurrent protection need only be at the supply of... to start. (c) Source of potential. The potential for a control, interlock, or indicator circuit must... disconnected from all sources of potential by a disconnect device independent of the motor and controller...

46 CFR 111.70-7 - Remote control, interlock, and indicator circuits.

Code of Federal Regulations, 2012 CFR

2012-10-01

... difference in potential between the external conductors, overcurrent protection need only be at the supply of... to start. (c) Source of potential. The potential for a control, interlock, or indicator circuit must... disconnected from all sources of potential by a disconnect device independent of the motor and controller...

46 CFR 111.70-7 - Remote control, interlock, and indicator circuits.

Code of Federal Regulations, 2010 CFR

2010-10-01

... difference in potential between the external conductors, overcurrent protection need only be at the supply of... to start. (c) Source of potential. The potential for a control, interlock, or indicator circuit must... disconnected from all sources of potential by a disconnect device independent of the motor and controller...

Analysis of Hydropower Potential Utilization of Watercourses in Slovakia

NASA Astrophysics Data System (ADS)

Gejguš, Mirko; Aschbacher, Christine; Sablik, Jozef

2017-09-01

This article analyzes the hydropower potential of watercourses in Slovakia, defining water as the most promising and most used renewable energy source. The hydro-energetic potential as a source of energy is determined by the calculation of the technically feasible potential of the watercourses, which is divided into exploited and unused. It also identifies the potential of utilizing the unused technical hydro-energetic potential.

Sources of endocrine-disrupting compounds in North Carolina waterways: a geographic information systems approach

USGS Publications Warehouse

Sackett, Dana K.; Pow, Crystal Lee; Rubino, Matthew J.; Aday, D.D.; Cope, W. Gregory; Kullman, Seth W.; Rice, J.A.; Kwak, Thomas J.; Law, L.M.

2015-01-01

The presence of endocrine-disrupting compounds (EDCs), particularly estrogenic compounds, in the environment has drawn public attention across the globe, yet a clear understanding of the extent and distribution of estrogenic EDCs in surface waters and their relationship to potential sources is lacking. The objective of the present study was to identify and examine the potential input of estrogenic EDC sources in North Carolina water bodies using a geographic information system (GIS) mapping and analysis approach. Existing data from state and federal agencies were used to create point and nonpoint source maps depicting the cumulative contribution of potential sources of estrogenic EDCs to North Carolina surface waters. Water was collected from 33 sites (12 associated with potential point sources, 12 associated with potential nonpoint sources, and 9 reference), to validate the predictive results of the GIS analysis. Estrogenicity (measured as 17β-estradiol equivalence) ranged from 0.06 ng/L to 56.9 ng/L. However, the majority of sites (88%) had water 17β-estradiol concentrations below 1 ng/L. Sites associated with point and nonpoint sources had significantly higher 17β-estradiol levels than reference sites. The results suggested that water 17β-estradiol was reflective of GIS predictions, confirming the relevance of landscape-level influences on water quality and validating the GIS approach to characterize such relationships.

Personal digital assistant-based drug information sources: potential to improve medication safety.

PubMed

Galt, Kimberly A; Rule, Ann M; Houghton, Bruce; Young, Daniel O; Remington, Gina

2005-04-01

This study compared the potential for personal digital assistant (PDA)-based drug information sources to minimize potential medication errors dependent on accurate and complete drug information at the point of care. A quality and safety framework for drug information resources was developed to evaluate 11 PDA-based drug information sources. Three drug information sources met the criteria of the framework: Eprocrates Rx Pro, Lexi-Drugs, and mobileMICROMEDEX. Medication error types related to drug information at the point of care were then determined. Forty-seven questions were developed to test the potential of the sources to prevent these error types. Pharmacists and physician experts from Creighton University created these questions based on the most common types of questions asked by primary care providers. Three physicians evaluated the drug information sources, rating the source for each question: 1=no information available, 2=some information available, or 3 = adequate amount of information available. The mean ratings for the drug information sources were: 2.0 (Eprocrates Rx Pro), 2.5 (Lexi-Drugs), and 2.03 (mobileMICROMEDEX). Lexi-Drugs was significantly better (mobileMICROMEDEX t test; P=0.05; Eprocrates Rx Pro t test; P=0.01). Lexi-Drugs was found to be the most specific and complete PDA resource available to optimize medication safety by reducing potential errors associated with drug information. No resource was sufficient to address the patient safety information needs for all cases.

Sources of endocrine-disrupting compounds in North Carolina waterways: a geographic information systems approach.

PubMed

Sackett, Dana K; Pow, Crystal Lee; Rubino, Matthew J; Aday, D Derek; Cope, W Gregory; Kullman, Seth; Rice, James A; Kwak, Thomas J; Law, Mac

2015-02-01

The presence of endocrine-disrupting compounds (EDCs), particularly estrogenic compounds, in the environment has drawn public attention across the globe, yet a clear understanding of the extent and distribution of estrogenic EDCs in surface waters and their relationship to potential sources is lacking. The objective of the present study was to identify and examine the potential input of estrogenic EDC sources in North Carolina water bodies using a geographic information system (GIS) mapping and analysis approach. Existing data from state and federal agencies were used to create point and nonpoint source maps depicting the cumulative contribution of potential sources of estrogenic EDCs to North Carolina surface waters. Water was collected from 33 sites (12 associated with potential point sources, 12 associated with potential nonpoint sources, and 9 reference), to validate the predictive results of the GIS analysis. Estrogenicity (measured as 17β-estradiol equivalence) ranged from 0.06 ng/L to 56.9 ng/L. However, the majority of sites (88%) had water 17β-estradiol concentrations below 1 ng/L. Sites associated with point and nonpoint sources had significantly higher 17β-estradiol levels than reference sites. The results suggested that water 17β-estradiol was reflective of GIS predictions, confirming the relevance of landscape-level influences on water quality and validating the GIS approach to characterize such relationships. © 2014 SETAC.

The potential for effluent trading in the energy industries.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Veil, J. A.; Environmental Assessment

1998-01-01

In January 1996, the US Environmental Protection Agency (EPA) released a policy statement endorsing wastewater effluent trading in watersheds, hoping to promote additional interest in the subject. The policy describes five types of effluent trades: point source/point source, point source/nonpoint source, pretreatment, intraplant and nonpoint source/nonpoint source. This paper evaluates the feasibility of implementing these types of effluent trading for facilities in the oil and gas, electric power and coal industries. This paper finds that the potential for effluent trading in these industries is limited because trades would generally need to involve toxic pollutants, which can only be traded undermore » a narrow range of circumstances. However, good potential exists for other types of water-related trades that do not directly involve effluents (e.g. wetlands mitigation banking and voluntary environmental projects). The potential for effluent trading in the energy industries and in other sectors would be enhanced if Congress amended the Clean Water Act (CWA) to formally authorize such trading.« less

Estimating and Testing the Sources of Evoked Potentials in the Brain.

ERIC Educational Resources Information Center

Huizenga, Hilde M.; Molenaar, Peter C. M.

1994-01-01

The source of an event-related brain potential (ERP) is estimated from multivariate measures of ERP on the head under several mathematical and physical constraints on the parameters of the source model. Statistical aspects of estimation are discussed, and new tests are proposed. (SLD)

Economic analysis of potential fuelwood sources

Treesearch

W.F. Watson; J.R. Ragan; T.J. Straka; B.J. Stokes

1987-01-01

Fuelwood can be producsd from mill residues, logging residues, or energy plantations. This paper will compare the last two sources on the basis of potential for productlon and expected costs at the various levels of productfon. Prospects for improving the production of fuelwood frw each source will also be examined.

Potential revenue sources for Virginia's transportation safety programs : review of Virginia's revenue sources and a survey of other states : final report.

DOT National Transportation Integrated Search

1992-01-01

Fearful that inflation and the gradual erosion of federal support for highway safety programs were undermining Virginia's historic position of national leadership in highway safety; management directed a study of potential sources of new revenue for ...

Milagro Observations of Potential TeV Emitters

NASA Astrophysics Data System (ADS)

Abeysekara, Anushka; Linnemann, James

2012-03-01

We searched for point sources in Milagro sky maps at the locations in four catalogs of potential TeV emitting sources. Our candidates are selected from the Fermi 2FGL pulsars, Fermi 2FGL extragalactic sources, TeVCat extragalactic sources, and from the BL Lac TeV Candidate list published by Costamante and Ghisellini in 2002. The False Discovery Rate (FDR) statistical procedure is used to select the sources. The FDR procedure controls the fraction of false detections. Our results are presented in this talk.

Baryon interactions in lattice QCD: the direct method vs. the HAL QCD potential method

NASA Astrophysics Data System (ADS)

Iritani, T.; HAL QCD Collaboration

We make a detailed comparison between the direct method and the HAL QCD potential method for the baryon-baryon interactions, taking the $\\Xi\\Xi$ system at $m_\\pi= 0.51$ GeV in 2+1 flavor QCD and using both smeared and wall quark sources. The energy shift $\\Delta E_\\mathrm{eff}(t)$ in the direct method shows the strong dependence on the choice of quark source operators, which means that the results with either (or both) source are false. The time-dependent HAL QCD method, on the other hand, gives the quark source independent $\\Xi\\Xi$ potential, thanks to the derivative expansion of the potential, which absorbs the source dependence to the next leading order correction. The HAL QCD potential predicts the absence of the bound state in the $\\Xi\\Xi$($^1$S$_0$) channel at $m_\\pi= 0.51$ GeV, which is also confirmed by the volume dependence of finite volume energy from the potential. We also demonstrate that the origin of the fake plateau in the effective energy shift $\\Delta E_\\mathrm{eff}(t)$ at $t \\sim 1$ fm can be clarified by a few low-lying eigenfunctions and eigenvalues on the finite volume derived from the HAL QCD potential, which implies that the ground state saturation of $\\Xi\\Xi$($^1$S$_0$) requires $t \\sim 10$ fm in the direct method for the smeared source on $(4.3 \\ \\mathrm{fm})^3$ lattice, while the HAL QCD method does not suffer from such a problem.

Hydrocarbon source rock potential of the Karoo in Zimbabwe

NASA Astrophysics Data System (ADS)

Hiller, K.; Shoko, U.

1996-07-01

The hydrocarbon potential of Zimbabwe is tied to the Karoo rifts which fringe the Zimbabwe Craton, i.e. the Mid-Zambezi basin/rift and the Mana Pools basin in the northwest, the Cabora Bassa basin in the north and the Tuli-Bubye and Sabi-Runde basins in the south. Based on the geochemical investigation of almost one thousand samples of fine clastic Karoo sediments, a concise source rock inventory has been established showing the following features. No marine source rocks have been identified. In the Mid-Zambezi area and Cabora Bassa basin, the source rocks are gas-prone, carbonaceous to coaly mudstones and coal of Lower Karoo age. In the Cabora Bassa basin, similar gas-prone source rocks occur in the Upper Karoo (Angwa Alternations Member). These kerogen type III source rocks are widespread and predominantly immature to moderately mature. In the southern basins, the Lower Karoo source rocks are gas-prone; in addition some have a small condensate potential. Most of the samples are, however, overmature due to numerous dolerite intrusions. Samples with a mixed gas, condensate and oil potential (mainly kerogen types II and III) were identified in the Lower Karoo (Coal Measure and Lower Madumabisa Mudstone Formations) of the Mid-Zambezi basin, and in the Louver Karoo (Mkanga Formation) and Upper Karoo (Upper Angwa Alternations Member Formation) of the Cabora Bassa basin. The source rocks, with a liquid potential, are also immature to moderately mature and were deposited in swamp, paludal and lacustrine environments of limited extent.

Source rock potential in Pakistan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Raza, H.A.

1991-03-01

Pakistan contains two sedimentary basins: Indus in the east and Balochistan in the west. The Indus basin has received sediments from precambrian until Recent, albeit with breaks. It has been producing hydrocarbons since 1914 from three main producing regions, namely, the Potwar, Sulaisman, and Kirthar. In the Potwar, oil has been discovered in Cambrian, Permian, Jurassic, and Tertiary rocks. Potential source rocks are identified in Infra-Cambrian, Permian, Paleocene, and Eocene successions, but Paleocene/Eocene Patala Formation seems to be the main source of most of the oil. In the Sulaiman, gas has been found in Cretaceous and Tertiary; condensate in Cretaceousmore » rocks. Potential source rocks are indicated in Cretaceous, Paleocene, and Eocene successions. The Sembar Formation of Early Cretaceous age appears to be the source of gas. In the Kirthar, oil and gas have been discovered in Cretaceous and gas has been discovered in paleocene and Eocene rocks. Potential source rocks are identified in Kirthar and Ghazij formations of Eocene age in the western part. However, in the easter oil- and gas-producing Badin platform area, Union Texas has recognized the Sembar Formation of Early Cretaceous age as the only source of Cretaceous oil and gas. The Balochistan basin is part of an Early Tertiary arc-trench system. The basin is inadequately explored, and there is no oil or gas discovery so far. However, potential source rocks have been identified in Eocene, Oligocene, Miocene, and Pliocene successions based on geochemical analysis of surface samples. Mud volcanoes are present.« less

Effect of source tuning parameters on the plasma potential of heavy ions in the 18 GHz high temperature superconducting electron cyclotron resonance ion source.

PubMed

Rodrigues, G; Baskaran, R; Kukrety, S; Mathur, Y; Kumar, Sarvesh; Mandal, A; Kanjilal, D; Roy, A

2012-03-01

Plasma potentials for various heavy ions have been measured using the retarding field technique in the 18 GHz high temperature superconducting ECR ion source, PKDELIS [C. Bieth, S. Kantas, P. Sortais, D. Kanjilal, G. Rodrigues, S. Milward, S. Harrison, and R. McMahon, Nucl. Instrum. Methods B 235, 498 (2005); D. Kanjilal, G. Rodrigues, P. Kumar, A. Mandal, A. Roy, C. Bieth, S. Kantas, and P. Sortais, Rev. Sci. Instrum. 77, 03A317 (2006)]. The ion beam extracted from the source is decelerated close to the location of a mesh which is polarized to the source potential and beams having different plasma potentials are measured on a Faraday cup located downstream of the mesh. The influence of various source parameters, viz., RF power, gas pressure, magnetic field, negative dc bias, and gas mixing on the plasma potential is studied. The study helped to find an upper limit of the energy spread of the heavy ions, which can influence the design of the longitudinal optics of the high current injector being developed at the Inter University Accelerator Centre. It is observed that the plasma potentials are decreasing for increasing charge states and a mass effect is clearly observed for the ions with similar operating gas pressures. In the case of gas mixing, it is observed that the plasma potential minimizes at an optimum value of the gas pressure of the mixing gas and the mean charge state maximizes at this value. Details of the measurements carried out as a function of various source parameters and its impact on the longitudinal optics are presented.

Three year study of tropospheric ozone with back trajectories at a metropolitan and a medium scale urban area in Greece.

PubMed

Dimitriou, Konstantinos; Kassomenos, Pavlos

2015-01-01

Three years of hourly O3 concentration measurements from a metropolitan and a medium scale urban area in Greece: Athens and Ioannina respectively, were analyzed in conjunction with hourly wind speed/direction data and air mass trajectories, aiming to reveal local and regional contributions respectively. Conditional Probability Function was used to indicate associations among distinct wind directions and extreme O3 episodes. Backward trajectory clusters were elaborated by Potential Source Contribution Function on a grid of a 0.5°×0.5° resolution, in order to localize potential exogenous sources of O3 and its precursors. In Athens, an increased likelihood of extreme O3 events at the Northern suburbs was associated with the influence of SSW-SW sea breeze from Saronikos Gulf, due to O3 transportation from the city center. In Ioannina, the impacts of O3 conveyance from the city center to the suburban monitoring site were weaker. Potential O3 transboundary sources for Athens were mainly localized over Balkan Peninsula, Greece and the Aegean Sea. Potential Source Contribution Function hotspots were isolated over the industrialized area of Ptolemaida basin and above the region of Thessaloniki. Potential regional O3 sources for Ioannina were indicated across northern Greece and Balkan Peninsula, whereas peak Potential Source Contribution Function values were particularly observed over the urban area of Sofia in Bulgaria. The implemented methods, revealed local and potential transboundary source areas of O3, influencing Athens and Ioannina. Differences among the two cities were highlighted and the role of topography was emerged. These findings can be used in order to reduce the emission of O3 precursors. Copyright © 2014 Elsevier B.V. All rights reserved.

Effect of source tuning parameters on the plasma potential of heavy ions in the 18 GHz high temperature superconducting electron cyclotron resonance ion source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rodrigues, G.; Mathur, Y.; Kumar, Sarvesh

2012-03-15

Plasma potentials for various heavy ions have been measured using the retarding field technique in the 18 GHz high temperature superconducting ECR ion source, PKDELIS [C. Bieth, S. Kantas, P. Sortais, D. Kanjilal, G. Rodrigues, S. Milward, S. Harrison, and R. McMahon, Nucl. Instrum. Methods B 235, 498 (2005); D. Kanjilal, G. Rodrigues, P. Kumar, A. Mandal, A. Roy, C. Bieth, S. Kantas, and P. Sortais, Rev. Sci. Instrum. 77, 03A317 (2006)]. The ion beam extracted from the source is decelerated close to the location of a mesh which is polarized to the source potential and beams having different plasmamore » potentials are measured on a Faraday cup located downstream of the mesh. The influence of various source parameters, viz., RF power, gas pressure, magnetic field, negative dc bias, and gas mixing on the plasma potential is studied. The study helped to find an upper limit of the energy spread of the heavy ions, which can influence the design of the longitudinal optics of the high current injector being developed at the Inter University Accelerator Centre. It is observed that the plasma potentials are decreasing for increasing charge states and a mass effect is clearly observed for the ions with similar operating gas pressures. In the case of gas mixing, it is observed that the plasma potential minimizes at an optimum value of the gas pressure of the mixing gas and the mean charge state maximizes at this value. Details of the measurements carried out as a function of various source parameters and its impact on the longitudinal optics are presented.« less

HIGH VOLTAGE ION SOURCE

DOEpatents

Luce, J.S.

1960-04-19

A device is described for providing a source of molecular ions having a large output current and with an accelerated energy of the order of 600 kv. Ions are produced in an ion source which is provided with a water-cooled source grid of metal to effect maximum recombination of atomic ions to molecular ions. A very high accelerating voltage is applied to withdraw and accelerate the molecular ions from the source, and means are provided for dumping the excess electrons at the lowest possible potentials. An accelerating grid is placed adjacent to the source grid and a slotted, grounded accelerating electrode is placed adjacent to the accelerating grid. A potential of about 35 kv is maintained between the source grid and accelerating grid, and a potential of about 600 kv is maintained between the accelerating grid and accelerating electrode. In order to keep at a minimum the large number of oscillating electrons which are created when such high voltages are employed in the vicinity of a strong magnetic field, a plurality of high voltage cascaded shields are employed with a conventional electron dumping system being employed between each shield so as to dump the electrons at the lowest possible potential rather than at 600 kv.

Energy sources for gynecologic laparoscopic surgery: a review of the literature.

PubMed

Law, Kenneth S K; Abbott, Jason A; Lyons, Stephen D

2014-12-01

A range of energy sources are used in gynecologic laparoscopy. These energy sources include monopolar electrosurgery, bipolar electrosurgery (including "advanced bipolar" devices that incorporate tissue feedback monitoring), and various types of laser and ultrasonic technologies. Gynecologists using these tools should be aware of the potential benefits and potential dangers of these instruments. This review provides an overview of the biophysics of these energy sources, their tissue effects, and the complications that may arise. It aims to highlight any potential advantages or disadvantages of various energy sources, as reported by clinical and laboratory studies. Literature relating to energy sources used in gynecologic laparoscopy was reviewed. While laboratory-based studies have reported differences between various energy sources, these differences may not be clinically significant. The choice of instrumentation may depend on the nature of the surgical task being performed, but other factors, such as the surgeon's training/experience, cost, and industry marketing, may also influence the decision. TAn awareness of the pros and cons of each energy modality and their relative efficacy profiles is paramount. It is important that surgeons have an understanding of the biophysics of these technologies in order to understand their limitations and potential dangers and to utilize the most appropriate energy source(s) in the appropriate clinical setting, in order to both minimize the risk of inadvertent injuries during gynecologic laparoscopy and to maximize cost-efficient delivery of health care.

Emotion impairs extrinsic source memory--An ERP study.

PubMed

Mao, Xinrui; You, Yuqi; Li, Wen; Guo, Chunyan

2015-09-01

Substantial advancements in understanding emotional modulation of item memory notwithstanding, controversies remain as to how emotion influences source memory. Using an emotional extrinsic source memory paradigm combined with remember/know judgments and two key event-related potentials (ERPs)-the FN400 (a frontal potential at 300-500 ms related to familiarity) and the LPC (a later parietal potential at 500-700 ms related to recollection), our research investigated the impact of emotion on extrinsic source memory and the underlying processes. We varied a semantic prompt (either "people" or "scene") preceding a study item to manipulate the extrinsic source. Behavioral data indicated a significant effect of emotion on "remember" responses to extrinsic source details, suggesting impaired recollection-based source memory in emotional (both positive and negative) relative to neutral conditions. In parallel, differential FN400 and LPC amplitudes (correctly remembered - incorrectly remembered sources) revealed emotion-related interference, suggesting impaired familiarity and recollection memory of extrinsic sources associated with positive or negative items. These findings thus lend support to the notion of emotion-induced memory trade off: while enhancing memory of central items and intrinsic/integral source details, emotion nevertheless disrupts memory of peripheral contextual details, potentially impairing both familiarity and recollection. Importantly, that positive and negative items result in comparable memory impairment suggests that arousal (vs. affective valence) plays a critical role in modulating dynamic interactions among automatic and elaborate processes involved in memory. Copyright © 2015 Elsevier B.V. All rights reserved.

Intracranial EEG potentials estimated from MEG sources: A new approach to correlate MEG and iEEG data in epilepsy.

PubMed

Grova, Christophe; Aiguabella, Maria; Zelmann, Rina; Lina, Jean-Marc; Hall, Jeffery A; Kobayashi, Eliane

2016-05-01

Detection of epileptic spikes in MagnetoEncephaloGraphy (MEG) requires synchronized neuronal activity over a minimum of 4cm2. We previously validated the Maximum Entropy on the Mean (MEM) as a source localization able to recover the spatial extent of the epileptic spike generators. The purpose of this study was to evaluate quantitatively, using intracranial EEG (iEEG), the spatial extent recovered from MEG sources by estimating iEEG potentials generated by these MEG sources. We evaluated five patients with focal epilepsy who had a pre-operative MEG acquisition and iEEG with MRI-compatible electrodes. Individual MEG epileptic spikes were localized along the cortical surface segmented from a pre-operative MRI, which was co-registered with the MRI obtained with iEEG electrodes in place for identification of iEEG contacts. An iEEG forward model estimated the influence of every dipolar source of the cortical surface on each iEEG contact. This iEEG forward model was applied to MEG sources to estimate iEEG potentials that would have been generated by these sources. MEG-estimated iEEG potentials were compared with measured iEEG potentials using four source localization methods: two variants of MEM and two standard methods equivalent to minimum norm and LORETA estimates. Our results demonstrated an excellent MEG/iEEG correspondence in the presumed focus for four out of five patients. In one patient, the deep generator identified in iEEG could not be localized in MEG. MEG-estimated iEEG potentials is a promising method to evaluate which MEG sources could be retrieved and validated with iEEG data, providing accurate results especially when applied to MEM localizations. Hum Brain Mapp 37:1661-1683, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

[Sources and potential risk of heavy metals in roadside soils of Xi' an City].

PubMed

Chen, Jing-hui; Lu, Xin-wei; Zhai, Meng

2011-07-01

Based on the X-Ray fluorescence spectroscopic measurement of heavy metals concentration in roadside soil samples from Xi' an City, and by the methods of principal component analysis, cluster analysis, and correlation analysis, this paper approached the possible sources of heavy metals in the roadside soils of the City. In the meantime, potential ecological risk index was used to assess the ecological risk of the heavy metals. In the roadside soils, the mean concentrations of Co, Cr, Cu, Mn, Ni, Pb, and Zn were higher than those of the Shaanxi soil background values. The As, Mn and Ni in roadside soils mainly came from natural source and transportation source, the Cu, Pb, and Zn mainly came from transportation source, and the Co and Cr mainly came from industry source. These heavy metals in the roadside soils belonged to medium pollution, and had medium potential ecological risk.

The versatile biopolymer chitosan: potential sources, evaluation of extraction methods and applications.

PubMed

Kaur, Surinder; Dhillon, Gurpreet Singh

2014-05-01

Among the biopolymers, chitin and its derivative chitosan (CTS) have been receiving increasing attention. Both are composed of randomly distributed β-(1-4)-linked d-glucosamine and N-acetyl glucosamine units. On commercial scale, CTS is mainly obtained from the crustacean shells. The chemical methods employed for extraction of CTS from crustacean shells are laden with many disadvantages. Waste fungal biomass represents a potential biological source of CTS, in fact with superior physico-chemical properties, such as high degree of deacetylation, low molecular weight, devoid of protein contamination and high bioactivity. Researchers around the globe are attempting to commercialize CTS production and extraction from fungal sources. Fungi are promising and environmentally benign source of CTS and they have the potential to completely replace crustacean-derived CTS. Waste fungal biomass resulting from various pharmaceutical and biotechnological industries is grown on inexpensive agro-industrial wastes and its by-products are a rich and inexpensive source of CTS. CTS is emerging as an important natural polymer having broad range of applications in different fields. In this context, the present review discusses the potential sources of CTS and their advantages and disadvantages. This review also deals with potential applications of CTS in different fields. Finally, the various attributes of CTS sought in different applications are discussed.

Shale characterization in mass transport complex as a potential source rock: An example from onshore West Java Basin, Indonesia

NASA Astrophysics Data System (ADS)

Nugraha, A. M. S.; Widiarti, R.; Kusumah, E. P.

2017-12-01

This study describes a deep-water slump facies shale of the Early Miocene Jatiluhur/Cibulakan Formation to understand its potential as a source rock in an active tectonic region, the onshore West Java. The formation is equivalent with the Gumai Formation, which has been well-known as another prolific source rock besides the Oligocene Talang Akar Formation in North West Java Basin, Indonesia. The equivalent shale formation is expected to have same potential source rock towards the onshore of Central Java. The shale samples were taken onshore, 150 km away from the basin. The shale must be rich of organic matter, have good quality of kerogen, and thermally matured to be categorized as a potential source rock. Investigations from petrography, X-Ray diffractions (XRD), and backscattered electron show heterogeneous mineralogy in the shales. The mineralogy consists of clay minerals, minor quartz, muscovite, calcite, chlorite, clinopyroxene, and other weathered minerals. This composition makes the shale more brittle. Scanning Electron Microscope (SEM) analysis indicate secondary porosities and microstructures. Total Organic Carbon (TOC) shows 0.8-1.1 wt%, compared to the basinal shale 1.5-8 wt%. The shale properties from this outcropped formation indicate a good potential source rock that can be found in the subsurface area with better quality and maturity.

Contamination of organic nutrient sources with potentially toxic elements, antibiotics and pathogen microorganisms in relation to P fertilizer potential and treatment options for the production of sustainable fertilizers: A review.

PubMed

Bloem, E; Albihn, A; Elving, J; Hermann, L; Lehmann, L; Sarvi, M; Schaaf, T; Schick, J; Turtola, E; Ylivainio, K

2017-12-31

Organic nutrient sources such as farmyard manure, sewage sludge, their biogas digestates or other animal by-products can be valuable fertilizers delivering organic matter to the soil. Currently, especially phosphorus (P) is in the focus of research since it is an essential plant nutrient with finite resources, estimated to last only for some more decades. Efficient utilization of organic P sources in agriculture will help to preserve P resources and thereby has the potential to close nutrient cycles and prevent unwanted P-losses to the environment, one of the major causes for eutrophication of water bodies. Unfortunately, organic P sources usually contain also various detrimental substances, such as potentially toxic elements or organic contaminants like pharmaceuticals as well as pathogenic microorganisms. Additionally, the utilization of some of these substrates such as sewage sludge or animal by-products is legally limited in agriculture because of the potential risk to contaminate sites with potentially toxic elements and organic contaminants. Thus, to close nutrient cycles it is important to develop solutions for the responsible use of organic nutrient sources. The aim of this review is to give an overview of the contamination of the most important organic nutrient sources with potentially toxic elements, antibiotics (as one important organic contaminant) and pathogenic microorganisms. Changes in manure and sewage sludge management as well as the increasing trend to use such substrates in biogas plants will be discussed with respect to potential risks posed to soils and water bodies. Some examples for abatement options by which contamination can be reduced to produce P fertilizers with high amounts of plant available P forms are presented. Copyright © 2017 Elsevier B.V. All rights reserved.

Slow positron beam generator for lifetime studies

NASA Technical Reports Server (NTRS)

Singh, Jag J. (Inventor); Eftekhari, Abe (Inventor); St.clair, Terry L. (Inventor)

1991-01-01

A slow positron beam generator uses a conductive source residing between two test films. Moderator pieces are placed next to the test film on the opposite side of the conductive source. A voltage potential is applied between the moderator pieces and the conductive source. Incident energetic positrons: (1) are emitted from the conductive source; (2) are passed through test film; and (3) isotropically strike moderator pieces before diffusing out of the moderator pieces as slow positrons, respectively. The slow positrons diffusing out of moderator pieces are attracted to the conductive source which is held at an appropriate potential below the moderator pieces. The slow positrons have to pass through the test films before reaching the conductive source. A voltage is adjusted so that the potential difference between the moderator pieces and the conductive source forces the positrons to stop in the test films. Measurable annihilation radiation is emitted from the test film when positrons annihilate (combine) with electrons in the test film.

Using smart card technology to monitor the eating habits of children in a school cafeteria: 1. Developing and validating the methodology.

PubMed

Lambert, N; Plumb, J; Looise, B; Johnson, I T; Harvey, I; Wheeler, C; Robinson, M; Rolfe, P

2005-08-01

The aim of the study was to test the feasibility of using smart card technology to track the eating behaviours of nearly a thousand children in a school cafeteria. Within a large boys' school a smart card based system was developed that was capable of providing a full electronic audit of all the individual transactions that occurred within the cafeteria. This dataset was interfaced to an electronic version of the McCance and Widdowson composition of foods dataset. The accuracy of the smart card generated data and the influence of portion size and wastage were determined empirically during two 5-day trials. The smart card system created succeeded in generating precise data on the food choices made by hundreds of children over an indefinite time period. The data was expanded to include a full nutrient analysis of all the foods chosen. The accuracy of this information was only constrained by the limitations facing all food composition research, e.g. variations in recipes, portion sizes, cooking practices, etc. Although technically possible to introduce wastage correction factors into the software, thereby providing information upon foods consumed, this was not seen as universally practical. The study demonstrated the power of smart card technology for monitoring food/nutrient choice over limitless time in environments such as school cafeterias. The strengths, limitations and applications of such technology are discussed.

Energy in the Mountain West: Colonialism and Independence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steven Piet; Lloyd Brown; Robert Cherry

2007-08-01

In many ways, the mountain west (Alaska, Arizona, Colorado, Idaho, Montana, New Mexico, Nevada, Utah, Wyoming) is an energy colony for the rest of the United States: it is rich in energy resources that are extracted to fuel economic growth in the wealthier and more populous coastal regions. Federal agencies and global corporations often behave as if the mountain west is a place to be exploited or managed for the benefit of customers and consumers elsewhere. Yet, the area. is not vast empty space with a limitless supply of natural resources, but rather a fast-growing region with a diverse economicmore » base dependent on a limited supply of water. New decision processes and collaborations are slowly changing this situation, but in a piecemeal fashion that places local communities at odds with powerful external interests. Proper planning of major development is needed to insure that the west has a strong economic and cultural future after the fossil energy resources decline, even if that might be a century from now. To encourage the necessary public discussions, this paper identifies key differences between the mountain west and the rest of the United States and suggests some holistic approaches that could improve our future. This paper is designed to provoke thought and discussion; it does not report new analyses on energy resources or usage. It is a summary of a large group effort.« less

Soft robotic arm inspired by the octopus: I. From biological functions to artificial requirements.

PubMed

Margheri, L; Laschi, C; Mazzolai, B

2012-06-01

Octopuses are molluscs that belong to the group Cephalopoda. They lack joints and rigid links, and as a result, their arms possess virtually limitless freedom of movement. These flexible appendages exhibit peculiar biomechanical features such as stiffness control, compliance, and high flexibility and dexterity. Studying the capabilities of the octopus arm is a complex task that presents a challenge for both biologists and roboticists, the latter of whom draw inspiration from the octopus in designing novel technologies within soft robotics. With this idea in mind, in this study, we used new, purposively developed methods of analysing the octopus arm in vivo to create new biologically inspired design concepts. Our measurements showed that the octopus arm can elongate by 70% in tandem with a 23% diameter reduction and exhibits an average pulling force of 40 N. The arm also exhibited a 20% mean shortening at a rate of 17.1 mm s(-1) and a longitudinal stiffening rate as high as 2 N (mm s)(-1). Using histology and ultrasounds, we investigated the functional morphology of the internal tissues, including the sinusoidal arrangement of the nerve cord and the local insertion points of the longitudinal and transverse muscle fibres. The resulting information was used to create novel design principles and specifications that can in turn be used in developing a new soft robotic arm.

From genetics to genomics: ethics, policy, and parental decision-making.

PubMed

Wilfond, Benjamin; Ross, Lainie Friedman

2009-07-01

Ethical evaluation of genetic testing in children is traditionally based on balancing clinical benefits and risks. However, this focus can be inconsistent with the general practice of respecting parental decision-making about their children's health care. We argue that respect for parental decision-making should play a larger role in shaping pediatric genetic testing practices, and play a similar role regarding decisions to use emerging genomic technologies. Genomic testing involves the examination of thousands of DNA markers spanning genes throughout the genome and their interrelationships, yielding virtually limitless interpretations. We presume that parents and providers should proceed cautiously in applying genomic testing in children, as we explore how genomic testing will stress the fault lines of the traditional ethical analysis. Empirical data about the psychosocial risks and benefits of genetic testing of children do not reveal serious harms, yet virtually no such data exist yet about genomic testing. Unless empirical social and behavioral data indicate that genomic testing is highly likely to cause serious harms to the children, parental decisions to obtain comprehensive genomic testing in their children should be respected. Once comprehensive genomic testing of children becomes routine, resultant information may be more easily integrated by families than anticipated. Research on the social and behavioral impact of comprehensive genomic testing on children and their families is needed to further inform parents, clinicians, and policy makers.

New insights into polyurethane biodegradation and realistic prospects for the development of a sustainable waste recycling process.

PubMed

Cregut, Mickael; Bedas, M; Durand, M-J; Thouand, G

2013-12-01

Polyurethanes are polymeric plastics that were first used as substitutes for traditional polymers suspected to release volatile organic hazardous substances. The limitless conformations and formulations of polyurethanes enabled their use in a wide variety of applications. Because approximately 10 Mt of polyurethanes is produced each year, environmental concern over their considerable contribution to landfill waste accumulation appeared in the 1990s. To date, no recycling processes allow for the efficient reuse of polyurethane waste due to their high resistance to (a)biotic disturbances. To find alternatives to systematic accumulation or incineration of polyurethanes, a bibliographic analysis was performed on major scientific advances in the polyurethane (bio)degradation field to identify opportunities for the development of new technologies to recondition this material. Until polymers exhibiting oxo- or hydro-biodegradative traits are generated, conventional polyurethanes that are known to be only slightly biodegradable are of great concern. The research focused on polyurethane biodegradation highlights recent attempts to reprocess conventional industrial polyurethanes via microbial or enzymatic degradation. This review describes several wonderful opportunities for the establishment of new processes for polyurethane recycling. Meeting these new challenges could lead to the development of sustainable management processes involving polymer recycling or reuse as environmentally safe options for industries. The ability to upgrade polyurethane wastes to chemical compounds with a higher added value would be especially attractive. © 2013.

Foam For Filtering

NASA Technical Reports Server (NTRS)

1978-01-01

Like nature's honeycomb, foam is a structure of many-sided cells, apparently solid but actually only three percent material and 97 percent air. Foam is made by a heat-producing chemical reaction which expands a plastic material in a manner somewhat akin to the heat-induced rising of a loaf of bread. The resulting structure of interconnected cells is flexible yet strong and extremely versatile in applicati6n. Foam can, for example, be a sound absorber in one form, while in another it allows sound to pass through it. It can be a very soft powder puff material and at the same time a highly abrasive scrubber. A sampling of foam uses includes stereo speaker grilles, applying postage meter ink, filtering lawnmower carburetor air; deadening noise in trucks and tractors, applying cosmetics, releasing fabric softener and antistatic agents in home clothes dryers, painting, filtering factory heating and ventilating systems, shining shoes, polishing cars, sponge-mopping floors, acting as pre-operative surgical scrubbers-the list is virtually limitless. The process by which foam is made produces "windows," thin plastic membranes connecting the cell walls. Windowed foam is used in many applications but for certain others-filtering, for example-it is desirable to have a completely open network. Scott Paper Company's Foam Division, Chester, Pennsylvania, improved a patented method of "removing the windows," to create an open structure that affords special utility in filtering applications. NASA technology contributed to Scott's improvement.

Précis of Simple heuristics that make us smart.

PubMed

Todd, P M; Gigerenzer, G

2000-10-01

How can anyone be rational in a world where knowledge is limited, time is pressing, and deep thought is often an unattainable luxury? Traditional models of unbounded rationality and optimization in cognitive science, economics, and animal behavior have tended to view decision-makers as possessing supernatural powers of reason, limitless knowledge, and endless time. But understanding decisions in the real world requires a more psychologically plausible notion of bounded rationality. In Simple heuristics that make us smart (Gigerenzer et al. 1999), we explore fast and frugal heuristics--simple rules in the mind's adaptive toolbox for making decisions with realistic mental resources. These heuristics can enable both living organisms and artificial systems to make smart choices quickly and with a minimum of information by exploiting the way that information is structured in particular environments. In this précis, we show how simple building blocks that control information search, stop search, and make decisions can be put together to form classes of heuristics, including: ignorance-based and one-reason decision making for choice, elimination models for categorization, and satisficing heuristics for sequential search. These simple heuristics perform comparably to more complex algorithms, particularly when generalizing to new data--that is, simplicity leads to robustness. We present evidence regarding when people use simple heuristics and describe the challenges to be addressed by this research program.

TRU Waste Management Program cost/schedule optimization analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Detamore, J.A.; Raudenbush, M.H.; Wolaver, R.W.

1985-10-01

The cost/schedule optimization task is a necessary function to insure that program goals and plans are optimized from a cost and schedule aspect. Results of this study will offer DOE information with which it can establish, within institutional constraints, the most efficient program for the long-term management and disposal of contact handled transuranic waste (CH-TRU). To this end, a comprehensive review of program cost/schedule tradeoffs has been made, to identify any major cost saving opportunities that may be realized by modification of current program plans. It was decided that all promising scenarios would be explored, and institutional limitations to implementationmore » would be described. Since a virtually limitless number of possible scenarios can be envisioned, it was necessary to distill these possibilities into a manageable number of alternatives. The resultant scenarios were described in the cost/schedule strategy and work plan document. Each scenario was compared with the base case: waste processing at the originating site; transport of CH-TRU wastes in TRUPACT; shipment of drums in 6-Packs; 25 year stored waste workoff; WIPP operational 10/88, with all sites shipping to WIPP beginning 10/88; and no processing at WIPP. Major savings were identified in two alternate scenarios: centralize waste processing at INEL and eliminate rail shipment of TRUPACT. No attempt was made to calculate savings due to combination of scenarios. 1 ref., 5 figs., 1 tab. (MHB)« less

[Philoctetes--a theme with variations].

PubMed

Thomasen, A L

1983-01-01

The legend of Philoctetes and his snake bite is found in so many versions seen from the most differing aspects, that each new attempt to throw light on this throng of literary and artistic interpretations must be based on the author's personal choice of and attitude to the almost limitless material. Since the time of Homer the legend has spread from ancient Greece across Europe, all the way to the utmost northern base of our culture; very early the tradition of the famous archer of the Trojan war was known and written down in Iceland. The author of the present essay has stressed the psychological interpretations of the legend as seen in the great Greek tragedies and in painting and sculpture, especially from the point of view of medical history. Furthermore the interplay of art and medicine in the Philoctetes legend has inspired the author to a closer examination of the role in the fate of mankind played by the snake from the beginning of time, seen in a religious as well as a secular context. For heathens as well as Christians the snake could bring fortune or calamity. Sometimes a vile demon, it brought harm; but the copper snake of Moses in the desert and the snake in the service of Asclepios protected and healed mankind. This creature so full of contrary powers and intentions almost became a mirror to the complex nature and unpredictable fate of man.

Threat-Related Information Suggests Competence: A Possible Factor in the Spread of Rumors

PubMed Central

Boyer, Pascal; Parren, Nora

2015-01-01

Information about potential danger is a central component of many rumors, urban legends, ritual prescriptions, religious prohibitions and witchcraft crazes. We investigate a potential factor in the cultural success of such material, namely that a source of threat-related information may be intuitively judged as more competent than a source that does not convey such information. In five studies, we asked participants to judge which of two sources of information, only one of which conveyed threat-related information, was more knowledgeable. Results suggest that mention of potential danger makes a source appear more competent than others, that the effect is not due to a general negativity bias, and that it concerns competence rather than a more generally positive evaluation of the source. PMID:26061409

Open-Source Data and the Study of Homicide.

PubMed

Parkin, William S; Gruenewald, Jeff

2015-07-20

To date, no discussion has taken place in the social sciences as to the appropriateness of using open-source data to augment, or replace, official data sources in homicide research. The purpose of this article is to examine whether open-source data have the potential to be used as a valid and reliable data source in testing theory and studying homicide. Official and open-source homicide data were collected as a case study in a single jurisdiction over a 1-year period. The data sets were compared to determine whether open-sources could recreate the population of homicides and variable responses collected in official data. Open-source data were able to replicate the population of homicides identified in the official data. Also, for every variable measured, the open-sources captured as much, or more, of the information presented in the official data. Also, variables not available in official data, but potentially useful for testing theory, were identified in open-sources. The results of the case study show that open-source data are potentially as effective as official data in identifying individual- and situational-level characteristics, provide access to variables not found in official homicide data, and offer geographic data that can be used to link macro-level characteristics to homicide events. © The Author(s) 2015.

Composition and potential origin of marine debris stranded in the Western Indian Ocean on remote Alphonse Island, Seychelles.

PubMed

Duhec, Aurélie V; Jeanne, Richard F; Maximenko, Nikolai; Hafner, Jan

2015-07-15

The abundance, composition, and potential sources of marine debris were investigated on remote Alphonse Island, during the austral winter 2013. A total of 4743 items, weighing 142 kg, were removed from 1 km of windward beach, facing the prevailing southeasterly trade winds. Our study demonstrates the prevalence of plastic debris as a world-wide marine contaminant. Characteristics of the debris suggest it originated primarily from land-based sources. To determine their potential geographic sources we used the Surface Current from Diagnostic model of near-surface ocean currents, forced by satellite sea level and wind data. While preliminary evidence indicated the Southeast Asia to be the main source of the flotsam, the model highlighted Somalia as another potential primary source. Our study concludes that most of the collected debris entered the sea as a result of inadequate waste management and demonstrates how anthropogenic waste can negatively impact even the most remote environments. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Low energy spread ion source with a coaxial magnetic filter

DOEpatents

Leung, Ka-Ngo; Lee, Yung-Hee Yvette

2000-01-01

Multicusp ion sources are capable of producing ions with low axial energy spread which are necessary in applications such as ion projection lithography (IPL) and radioactive ion beam production. The addition of a radially extending magnetic filter consisting of a pair of permanent magnets to the multicusp source reduces the energy spread considerably due to the improvement in the uniformity of the axial plasma potential distribution in the discharge region. A coaxial multicusp ion source designed to further reduce the energy spread utilizes a cylindrical magnetic filter to achieve a more uniform axial plasma potential distribution. The coaxial magnetic filter divides the source chamber into an outer annular discharge region in which the plasma is produced and a coaxial inner ion extraction region into which the ions radially diffuse but from which ionizing electrons are excluded. The energy spread in the coaxial source has been measured to be 0.6 eV. Unlike other ion sources, the coaxial source has the capability of adjusting the radial plasma potential distribution and therefore the transverse ion temperature (or beam emittance).

Assessment of hydrogeologic terrains, well-construction characteristics, groundwater hydraulics, and water-quality and microbial data for determination of surface-water-influenced groundwater supplies in West Virginia

USGS Publications Warehouse

Kozar, Mark D.; Paybins, Katherine S.

2016-08-30

Groundwater public-supply systems in areas of high intrinsic susceptibility and with a large number of potential contaminant sources within the recharge or source-water-protection area of individual wells or well fields are potentially vulnerable to contamination and probably warrant further evaluation as potential SWIGS. However, measures can be taken to educate the local population and initiate safety protocols and protective strategies to appropriately manage contaminant sources to prevent release of contaminants to the aquifer, therefore, reducing vulnerability of these systems to contamination. However, each public groundwater supply source needs to be assessed on an individual basis. Data presented in this report can be used to categorize and prioritize wells and springs that have a high potential for intrinsic susceptibility or vulnerability to contamination.

Comparison of hybrid receptor models to locate PCB sources in Chicago

NASA Astrophysics Data System (ADS)

Hsu, Ying-Kuang; Holsen, Thomas M.; Hopke, Philip K.

Results of three hybrid receptor models, potential source contribution function (PSCF), concentration weighted trajectory (CWT), and residence time weighted concentration (RTWC), were compared for locating polychlorinated biphenyl (PCB) sources contributing to the atmospheric concentrations in Chicago. Variations of these models, including PSCF using mean and 75% criterion concentrations, joint probability PSCF (JP-PSCF), changes of point filters and grid cell sizes for RTWC, and PSCF using wind trajectories started at different altitudes, are also discussed. Modeling results were relatively consistent between models. However, no single model provided as complete information as was obtained by using all of them. CWT and 75% PSCF appears to be able to distinguish between larger sources and moderate ones. RTWC resolved high potential source areas. RTWC and JP-PSCF pooling data from all sampling sites removed the trailing effect often seen in PSCF modeling. PSCF results using average concentration criteria, appears to identify both moderate and major sources. Each model has advantages and disadvantages. However, used in combination, they provide information that is not available if only one of them is used. For short-range atmospheric transport, PSCF results were consistent when using wind trajectories starting at different heights. Based on the archived PCB data, the modeling results indicate there is a large potential source area between Joliet and Kankakee, IL, and two moderate sources to the northwest and south of Chicago. On the south side of Chicago in the neighborhood of Lake Calumet, several PCB sources were identified. Other unidentified potential source location(s) will require additional upwind/downwind field sampling to verify modeling results.

40 CFR 55.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... potential to emit any air pollutant; (2) Is regulated or authorized under the Outer Continental Shelf Lands... the OCSLA (43 U.S.C. § 1331 et seq.). Potential emissions means the maximum emissions of a pollutant... the source when within 25 miles of the source, and shall be included in the “potential to emit” for an...

40 CFR 55.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... potential to emit any air pollutant; (2) Is regulated or authorized under the Outer Continental Shelf Lands... the OCSLA (43 U.S.C. § 1331 et seq.). Potential emissions means the maximum emissions of a pollutant... the source when within 25 miles of the source, and shall be included in the “potential to emit” for an...

40 CFR 55.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... potential to emit any air pollutant; (2) Is regulated or authorized under the Outer Continental Shelf Lands... the OCSLA (43 U.S.C. § 1331 et seq.). Potential emissions means the maximum emissions of a pollutant... the source when within 25 miles of the source, and shall be included in the “potential to emit” for an...

40 CFR 55.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... potential to emit any air pollutant; (2) Is regulated or authorized under the Outer Continental Shelf Lands... the OCSLA (43 U.S.C. § 1331 et seq.). Potential emissions means the maximum emissions of a pollutant... the source when within 25 miles of the source, and shall be included in the “potential to emit” for an...

75 FR 56080 - Intent To Prepare a Draft Programmatic Environmental Impact Statement (PEIS) for the Development...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-15

..., beneficial use dredging projects/ opportunities, FEMA reimbursement projects, and other potential sand placement or beach maintenance activities (beach bulldozing, etc.). Potential sand source locations to be... associated with using inlets as a sand source. d. Potential impacts to public lands, such as adjacent State...

Second generation bioethanol potential from selected Malaysia's biodiversity biomasses: A review.

PubMed

Aditiya, H B; Chong, W T; Mahlia, T M I; Sebayang, A H; Berawi, M A; Nur, Hadi

2016-01-01

Rising global temperature, worsening air quality and drastic declining of fossil fuel reserve are the inevitable phenomena from the disorganized energy management. Bioethanol is believed to clear out the effects as being an energy-derivable product sourced from renewable organic sources. Second generation bioethanol interests many researches from its unique source of inedible biomass, and this paper presents the potential of several selected biomasses from Malaysia case. As one of countries with rich biodiversity, Malaysia holds enormous potential in second generation bioethanol production from its various agricultural and forestry biomasses, which are the source of lignocellulosic and starch compounds. This paper reviews potentials of biomasses and potential ethanol yield from oil palm, paddy (rice), pineapple, banana and durian, as the common agricultural waste in the country but uncommon to be served as bioethanol feedstock, by calculating the theoretical conversion of cellulose, hemicellulose and starch components of the biomasses into bioethanol. Moreover, the potential of the biomasses as feedstock are discussed based on several reported works. Copyright © 2015 Elsevier Ltd. All rights reserved.

Solar glare hazard analysis tool on account of determined points of time

DOEpatents

Ho, Clifford K; Sims, Cianan Alexander

2014-09-23

Technologies pertaining to determining when glare will be perceived by a hypothetical observer from a glare source and the intensity of glare that will be perceived by the hypothetical observer from the glare source are described herein. A first location of a potential source of solar glare is received, and a second location of the hypothetical observer is received. Based upon such locations, including respective elevations, and known positions of the sun over time, a determination as to when the hypothetical observer will perceive glare from the potential source of solar glare is made. Subsequently, an amount of irradiance entering the eye of the hypothetical observer is calculated to assess potential ocular hazards.

Challenges and constraints of dynamically emerged source and sink in atomtronic circuits: From closed-system to open-system approaches

PubMed Central

Lai, Chen-Yen; Chien, Chih-Chun

2016-01-01

While batteries offer electronic source and sink for electronic devices, atomic analogues of source and sink and their theoretical descriptions have been a challenge in cold-atom systems. Here we consider dynamically emerged local potentials as controllable source and sink for bosonic atoms. Although a sink potential can collect bosons in equilibrium and indicate its usefulness in the adiabatic limit, sudden switching of the potential exhibits low effectiveness in pushing bosons into it. This is due to conservation of energy and particle in isolated systems such as cold atoms. By varying the potential depth and interaction strength, the systems can further exhibit averse response, where a deeper emerged potential attracts less bosonic atoms into it. To explore possibilities for improving the effectiveness, we investigate what types of system-environment coupling can help bring bosons into a dynamically emerged sink, and a Lindblad operator corresponding to local cooling is found to serve the purpose. PMID:27849034

Ion diffusion may introduce spurious current sources in current-source density (CSD) analysis.

PubMed

Halnes, Geir; Mäki-Marttunen, Tuomo; Pettersen, Klas H; Andreassen, Ole A; Einevoll, Gaute T

2017-07-01

Current-source density (CSD) analysis is a well-established method for analyzing recorded local field potentials (LFPs), that is, the low-frequency part of extracellular potentials. Standard CSD theory is based on the assumption that all extracellular currents are purely ohmic, and thus neglects the possible impact from ionic diffusion on recorded potentials. However, it has previously been shown that in physiological conditions with large ion-concentration gradients, diffusive currents can evoke slow shifts in extracellular potentials. Using computer simulations, we here show that diffusion-evoked potential shifts can introduce errors in standard CSD analysis, and can lead to prediction of spurious current sources. Further, we here show that the diffusion-evoked prediction errors can be removed by using an improved CSD estimator which accounts for concentration-dependent effects. NEW & NOTEWORTHY Standard CSD analysis does not account for ionic diffusion. Using biophysically realistic computer simulations, we show that unaccounted-for diffusive currents can lead to the prediction of spurious current sources. This finding may be of strong interest for in vivo electrophysiologists doing extracellular recordings in general, and CSD analysis in particular. Copyright © 2017 the American Physiological Society.

Redox potential distribution of an organic-rich contaminated site obtained by the inversion of self-potential data

NASA Astrophysics Data System (ADS)

Abbas, M.; Jardani, A.; Soueid Ahmed, A.; Revil, A.; Brigaud, L.; Bégassat, Ph.; Dupont, J. P.

2017-11-01

Mapping the redox potential of shallow aquifers impacted by hydrocarbon contaminant plumes is important for the characterization and remediation of such contaminated sites. The redox potential of groundwater is indicative of the biodegradation of hydrocarbons and is important in delineating the shapes of contaminant plumes. The self-potential method was used to reconstruct the redox potential of groundwater associated with an organic-rich contaminant plume in northern France. The self-potential technique is a passive technique consisting in recording the electrical potential distribution at the surface of the Earth. A self-potential map is essentially the sum of two contributions, one associated with groundwater flow referred to as the electrokinetic component, and one associated with redox potential anomalies referred to as the electroredox component (thermoelectric and diffusion potentials are generally negligible). A groundwater flow model was first used to remove the electrokinetic component from the observed self-potential data. Then, a residual self-potential map was obtained. The source current density generating the residual self-potential signals is assumed to be associated with the position of the water table, an interface characterized by a change in both the electrical conductivity and the redox potential. The source current density was obtained through an inverse problem by minimizing a cost function including a data misfit contribution and a regularizer. This inversion algorithm allows the determination of the vertical and horizontal components of the source current density taking into account the electrical conductivity distribution of the saturated and non-saturated zones obtained independently by electrical resistivity tomography. The redox potential distribution was finally determined from the inverted residual source current density. A redox map was successfully built and the estimated redox potential values correlated well with in-situ measurements.

Publications - GMC 209 | Alaska Division of Geological & Geophysical

Science.gov Websites

DGGS GMC 209 Publication Details Title: Source rock potential and geochemical characterization of OCS Y Reference DGSI, Inc., 1993, Source rock potential and geochemical characterization of OCS Y-0943-1 (Aurora

SWOT analysis of the renewable energy sources in Romania - case study: solar energy

NASA Astrophysics Data System (ADS)

Lupu, A. G.; Dumencu, A.; Atanasiu, M. V.; Panaite, C. E.; Dumitrașcu, Gh; Popescu, A.

2016-08-01

The evolution of energy sector worldwide triggered intense preoccupation on both finding alternative renewable energy sources and environmental issues. Romania is considered to have technological potential and geographical location suitable to renewable energy usage for electricity generation. But this high potential is not fully exploited in the context of policies and regulations adopted globally, and more specific, European Union (EU) environmental and energy strategies and legislation related to renewable energy sources. This SWOT analysis of solar energy source presents the state of the art, potential and future prospects for development of renewable energy in Romania. The analysis concluded that the development of solar energy sector in Romania depends largely on: viability of legislative framework on renewable energy sources, increased subsidies for solar R&D, simplified methodology of green certificates, and educating the public, investors, developers and decision-makers.

A two dimensional analytical modeling of surface potential in triple metal gate (TMG) fully-depleted Recessed-Source/Drain (Re-S/D) SOI MOSFET

NASA Astrophysics Data System (ADS)

Priya, Anjali; Mishra, Ram Awadh

2016-04-01

In this paper, analytical modeling of surface potential is proposed for new Triple Metal Gate (TMG) fully depleted Recessed-Source/Dain Silicon On Insulator (SOI) Metal Oxide Semiconductor Field Effect Transistor (MOSFET). The metal with the highest work function is arranged near the source region and the lowest one near the drain. Since Recessed-Source/Drain SOI MOSFET has higher drain current as compared to conventional SOI MOSFET due to large source and drain region. The surface potential model developed by 2D Poisson's equation is verified by comparison to the simulation result of 2-dimensional ATLAS simulator. The model is compared with DMG and SMG devices and analysed for different device parameters. The ratio of metal gate length is varied to optimize the result.

High-Performance Single-Photon Sources via Spatial Multiplexing

DTIC Science & Technology

2014-01-01

ingredient for tasks such as quantum cryptography , quantum repeater, quantum teleportation, quantum computing, and truly-random number generation. Recently...SECURITY CLASSIFICATION OF: Single photons sources are desired for many potential quantum information applications. One common method to produce...photons sources are desired for many potential quantum information applications. One common method to produce single photons is based on a “heralding

Potential of the desert locust schistocerca gregaria (Orthoptera: Acrididae) as an unconventional source of dietary and therapeutic sterols

USDA-ARS?s Scientific Manuscript database

Insects are increasingly being recognized not only as a source of food to feed the ever growing world population but also as potential sources of new products and therapeutic agents, among which are sterols. In this study, we sought to profile sterols and their derivatives present in the desert locu...

Assessment of hydrocarbon source rock potential of Polish bituminous coals and carbonaceous shales

USGS Publications Warehouse

Kotarba, M.J.; Clayton, J.L.; Rice, D.D.; Wagner, M.

2002-01-01

We analyzed 40 coal samples and 45 carbonaceous shale samples of varying thermal maturity (vitrinite reflectance 0.59% to 4.28%) from the Upper Carboniferous coal-bearing strata of the Upper Silesian, Lower Silesian, and Lublin basins, Poland, to evaluate their potential for generation and expulsion of gaseous and liquid hydrocarbons. We evaluated source rock potential based on Rock-Eval pyrolysis yield, elemental composition (atomic H/C and O/C), and solvent extraction yields of bitumen. An attempt was made to relate maceral composition to these source rock parameters and to composition of the organic matter and likely biological precursors. A few carbonaceous shale samples contain sufficient generation potential (pyrolysis assay and elemental composition) to be considered potential source rocks, although the extractable hydrocarbon and bitumen yields are lower than those reported in previous studies for effective Type III source rocks. Most samples analysed contain insufficient capacity for generation of hydrocarbons to reach thresholds required for expulsion (primary migration) to occur. In view of these findings, it is improbable that any of the coals or carbonaceous shales at the sites sampled in our study would be capable of expelling commercial amounts of oil. Inasmuch as a few samples contained sufficient generation capacity to be considered potential source rocks, it is possible that some locations or stratigraphic zones within the coals and shales could have favourable potential, but could not be clearly delimited with the number of samples analysed in our study. Because of their high heteroatomic content and high amount of asphaltenes, the bitumens contained in the coals are less capable of generating hydrocarbons even under optimal thermal conditions than their counterpart bitumens in the shales which have a lower heteroatomic content. Published by Elsevier Science B.V.

A Tiered Approach to Evaluating Salinity Sources in Water at Oil and Gas Production Sites.

PubMed

Paquette, Shawn M; Molofsky, Lisa J; Connor, John A; Walker, Kenneth L; Hopkins, Harley; Chakraborty, Ayan

2017-09-01

A suspected increase in the salinity of fresh water resources can trigger a site investigation to identify the source(s) of salinity and the extent of any impacts. These investigations can be complicated by the presence of naturally elevated total dissolved solids or chlorides concentrations, multiple potential sources of salinity, and incomplete data and information on both naturally occurring conditions and the characteristics of potential sources. As a result, data evaluation techniques that are effective at one site may not be effective at another. In order to match the complexity of the evaluation effort to the complexity of the specific site, this paper presents a strategic tiered approach that utilizes established techniques for evaluating and identifying the source(s) of salinity in an efficient step-by-step manner. The tiered approach includes: (1) a simple screening process to evaluate whether an impact has occurred and if the source is readily apparent; (2) basic geochemical characterization of the impacted water resource(s) and potential salinity sources coupled with simple visual and statistical data evaluation methods to determine the source(s); and (3) advanced laboratory analyses (e.g., isotopes) and data evaluation methods to identify the source(s) and the extent of salinity impacts where it was not otherwise conclusive. A case study from the U.S. Gulf Coast is presented to illustrate the application of this tiered approach. © 2017, National Ground Water Association.

The impact of catchment source group classification on the accuracy of sediment fingerprinting outputs.

PubMed

Pulley, Simon; Foster, Ian; Collins, Adrian L

2017-06-01

The objective classification of sediment source groups is at present an under-investigated aspect of source tracing studies, which has the potential to statistically improve discrimination between sediment sources and reduce uncertainty. This paper investigates this potential using three different source group classification schemes. The first classification scheme was simple surface and subsurface groupings (Scheme 1). The tracer signatures were then used in a two-step cluster analysis to identify the sediment source groupings naturally defined by the tracer signatures (Scheme 2). The cluster source groups were then modified by splitting each one into a surface and subsurface component to suit catchment management goals (Scheme 3). The schemes were tested using artificial mixtures of sediment source samples. Controlled corruptions were made to some of the mixtures to mimic the potential causes of tracer non-conservatism present when using tracers in natural fluvial environments. It was determined how accurately the known proportions of sediment sources in the mixtures were identified after unmixing modelling using the three classification schemes. The cluster analysis derived source groups (2) significantly increased tracer variability ratios (inter-/intra-source group variability) (up to 2122%, median 194%) compared to the surface and subsurface groupings (1). As a result, the composition of the artificial mixtures was identified an average of 9.8% more accurately on the 0-100% contribution scale. It was found that the cluster groups could be reclassified into a surface and subsurface component (3) with no significant increase in composite uncertainty (a 0.1% increase over Scheme 2). The far smaller effects of simulated tracer non-conservatism for the cluster analysis based schemes (2 and 3) was primarily attributed to the increased inter-group variability producing a far larger sediment source signal that the non-conservatism noise (1). Modified cluster analysis based classification methods have the potential to reduce composite uncertainty significantly in future source tracing studies. Copyright © 2016 Elsevier Ltd. All rights reserved.

Ozone depletion and chlorine loading potentials

NASA Technical Reports Server (NTRS)

Pyle, John A.; Wuebbles, Donald J.; Solomon, Susan; Zvenigorodsky, Sergei; Connell, Peter; Ko, Malcolm K. W.; Fisher, Donald A.; Stordal, Frode; Weisenstein, Debra

1991-01-01

The recognition of the roles of chlorine and bromine compounds in ozone depletion has led to the regulation or their source gases. Some source gases are expected to be more damaging to the ozone layer than others, so that scientific guidance regarding their relative impacts is needed for regulatory purposes. Parameters used for this purpose include the steady-state and time-dependent chlorine loading potential (CLP) and the ozone depletion potential (ODP). Chlorine loading potentials depend upon the estimated value and accuracy of atmospheric lifetimes and are subject to significant (approximately 20-50 percent) uncertainties for many gases. Ozone depletion potentials depend on the same factors, as well as the evaluation of the release of reactive chlorine and bromine from each source gas and corresponding ozone destruction within the stratosphere.

Identifying potential impact of lead contamination using a geographic information system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bocco, G.; Sanchez, R.

1997-01-01

The main objective of this research was to identify the potential hazards associated with lead contamination from fixed sources in the city of Tijuana. An exploratory model is presented that describes the potential polluting sources as well as the exposed universe. The results of the analysis provide a clear picture of the geographic distribution of hazards areas for potential lead pollution in Tijuana. The findings are indicative of the dramatic consequences of rapid industrialization and urbanization in a city where there have not been significant planning efforts to mitigate the negative effects of this growth. The approach followed helps tomore » narrow the universe of potential pollution sources, which can help to direct attention, research priorities, and resources to the most critical areas. 16 refs.« less

Are research papers reporting results from nutrigenetics clinical research a potential source of biohype?

PubMed

Stenne, R; Hurlimann, T; Godard, Béatrice

2012-01-01

Nutrigenetics is a promising field, but the achievability of expected benefits is challenged by the methodological limitations that are associated with clinical research in that field. The mere existence of these limitations suggests that promises about potential outcomes may be premature. Thus, benefits claimed in scientific journal articles in which these limitations are not acknowledged might stimulate biohype. This article aims to examine whether nutrigenetics clinical research articles are a potential source of biohype. Of the 173 articles identified, 16 contained claims in which clinical applications were extrapolated from study results. The methodological limitations being incompletely acknowledged, these articles could potentially be a source of biohype.

Modified method for estimating petroleum source-rock potential using wireline logs, with application to the Kingak Shale, Alaska North Slope

USGS Publications Warehouse

Rouse, William A.; Houseknecht, David W.

2016-02-11

In 2012, the U.S. Geological Survey completed an assessment of undiscovered, technically recoverable oil and gas resources in three source rocks of the Alaska North Slope, including the lower part of the Jurassic to Lower Cretaceous Kingak Shale. In order to identify organic shale potential in the absence of a robust geochemical dataset from the lower Kingak Shale, we introduce two quantitative parameters, $\\Delta DT_\\bar{x}$ and $\\Delta DT_z$, estimated from wireline logs from exploration wells and based in part on the commonly used delta-log resistivity ($\\Delta \\text{ }log\\text{ }R$) technique. Calculation of $\\Delta DT_\\bar{x}$ and $\\Delta DT_z$ is intended to produce objective parameters that may be proportional to the quality and volume, respectively, of potential source rocks penetrated by a well and can be used as mapping parameters to convey the spatial distribution of source-rock potential. Both the $\\Delta DT_\\bar{x}$ and $\\Delta DT_z$ mapping parameters show increased source-rock potential from north to south across the North Slope, with the largest values at the toe of clinoforms in the lower Kingak Shale. Because thermal maturity is not considered in the calculation of $\\Delta DT_\\bar{x}$ or $\\Delta DT_z$, total organic carbon values for individual wells cannot be calculated on the basis of $\\Delta DT_\\bar{x}$ or $\\Delta DT_z$ alone. Therefore, the $\\Delta DT_\\bar{x}$ and $\\Delta DT_z$ mapping parameters should be viewed as first-step reconnaissance tools for identifying source-rock potential.

An novel identification method of the environmental risk sources for surface water pollution accidents in chemical industrial parks.

PubMed

Peng, Jianfeng; Song, Yonghui; Yuan, Peng; Xiao, Shuhu; Han, Lu

2013-07-01

The chemical industry is a major source of various pollution accidents. Improving the management level of risk sources for pollution accidents has become an urgent demand for most industrialized countries. In pollution accidents, the released chemicals harm the receptors to some extent depending on their sensitivity or susceptibility. Therefore, identifying the potential risk sources from such a large number of chemical enterprises has become pressingly urgent. Based on the simulation of the whole accident process, a novel and expandable identification method for risk sources causing water pollution accidents is presented. The newly developed approach, by analyzing and stimulating the whole process of a pollution accident between sources and receptors, can be applied to identify risk sources, especially on the nationwide scale. Three major types of losses, such as social, economic and ecological losses, were normalized, analyzed and used for overall consequence modeling. A specific case study area, located in a chemical industry park (CIP) along the Yangtze River in Jiangsu Province, China, was selected to test the potential of the identification method. The results showed that there were four risk sources for pollution accidents in this CIP. Aniline leakage in the HS Chemical Plant would lead to the most serious impact on the surrounding water environment. This potential accident would severely damage the ecosystem up to 3.8 km downstream of Yangtze River, and lead to pollution over a distance stretching to 73.7 km downstream. The proposed method is easily extended to the nationwide identification of potential risk sources.

Multiwavelength Study of the Bright X-ray Source Population in the Interacting Galaxies NGC 5774/NGC 5775

NASA Technical Reports Server (NTRS)

Ghosh, Kajal K.; Swartz, Douglas A.; Tennant, Allyn F.; Saripalli, Lakshmi; Gandhi, Poshak; Foellmi, Cedric; Gutierrez, Carlos M.; Lopez-Corredoira, Martin

2006-01-01

The X-ray source population in the field of the interacting pair of galaxies NGC 5774/5775 is reported. A total of 49 discrete sources are detected, including 12 ultraluminous X-ray source candidates with lum inosities above 10(exp 39)erg/s in the 0.5 - 8.0 keV X-ray band. Several of these latter are transient X-ray sources that fall below detect ion levels in one of two X-ray observations spaced 15 months apart. X-ray source positions are mapped onto optical and radio images to sear ch for potential counterparts. Eleven sources have optically-bright c ounterparts. Optical colors are used to differentiate these sources, which are mostly located outside the optical extent of the interacting galaxies, as potential globular clusters (3 sources) and quasars (5) . Follow-up optical spectroscopy confirms two of the latter are background quasars.

Evaluation of potential sources and transport mechanisms of fecal indicator bacteria to beach water, Murphy Park Beach, Door County, Wisconsin

USGS Publications Warehouse

Juckem, Paul F.; Corsi, Steven R.; McDermott, Colleen; Kleinheinz, Gregory; Fogarty, Lisa R.; Haack, Sheridan K.; Johnson, Heather E.

2013-01-01

Fecal Indicator Bacteria (FIB) concentrations in beach water have been used for many years as a criterion for closing beaches due to potential health concerns. Yet, current understanding of sources and transport mechanisms that drive FIB occurrence remains insufficient for accurate prediction of closures at many beaches. Murphy Park Beach, a relatively pristine beach on Green Bay in Door County, Wis., was selected for a study to evaluate FIB sources and transport mechanisms. Although the relatively pristine nature of the beach yielded no detection of pathogenic bacterial genes and relatively low FIB concentrations during the study period compared with other Great Lakes Beaches, its selection limited the number of confounding FIB sources and associated transport mechanisms. The primary sources of FIB appear to be internal to the beach rather than external sources such as rivers, storm sewer outfalls, and industrial discharges. Three potential FIB sources were identified: sand, swash-zone groundwater, and Cladophora mats. Modest correlations between FIB concentrations in these potential source reservoirs and FIB concentrations at the beach from the same day illustrate the importance of understanding transport mechanisms between FIB sources and the water column. One likely mechanism for transport and dispersion of FIB from sand and Cladophora sources appears to be agitation of Cladophora mats and erosion of beach sand due to storm activity, as inferred from storm indicators including turbidity, wave height, current speed, wind speed, sky visibility, 24-hour precipitation, and suspended particulate concentration. FIB concentrations in beach water had a statistically significant relation (p-value ‹0.05) with the magnitude of these storm indicators. In addition, transport of FIB in swash-zone groundwater into beach water appears to be driven by groundwater recharge associated with multiday precipitation and corresponding increased swash-zone groundwater discharge at the beach, as indicated by an increase in the specific conductance of beach water. Understanding the dynamics of FIB sources (sand, swash-zone groundwater, and Cladophora) and transport mechanisms (dispersion and erosion from storm energy, and swash-zone groundwater discharge) is important for improving predictions of potential health risks from FIB in beach water.

Self-constrained inversion of potential fields

NASA Astrophysics Data System (ADS)

Paoletti, V.; Ialongo, S.; Florio, G.; Fedi, M.; Cella, F.

2013-11-01

We present a potential-field-constrained inversion procedure based on a priori information derived exclusively from the analysis of the gravity and magnetic data (self-constrained inversion). The procedure is designed to be applied to underdetermined problems and involves scenarios where the source distribution can be assumed to be of simple character. To set up effective constraints, we first estimate through the analysis of the gravity or magnetic field some or all of the following source parameters: the source depth-to-the-top, the structural index, the horizontal position of the source body edges and their dip. The second step is incorporating the information related to these constraints in the objective function as depth and spatial weighting functions. We show, through 2-D and 3-D synthetic and real data examples, that potential field-based constraints, for example, structural index, source boundaries and others, are usually enough to obtain substantial improvement in the density and magnetization models.

Geochemical Analysis of Parasequences within the Productive Middle Member of the Eagle Ford Formation at Lozier Canyon near Del Rio, Texas

NASA Astrophysics Data System (ADS)

Shane, Timothy E.

The middle member of the Eagle Ford formation is a heterogeneous, carbonate-shale unit that is a focus of unconventional oil and gas exploration in southern Texas. Exploration results have been mixed because of the apparent heterogeneity of the member. In this study, the extent of heterogeneities in the Eagle Ford on the "bedding-scale" were examined by evaluating changes in organic and inorganic geochemistry. Samples were collected vertically in outcrop covering four non-consecutive parasequences. These samples were analyzed using a Rock Eval 6 Analyzer(TM) to determine source rock generative potential and a Niton(TM) XRF to evaluate inorganic geochemistry to identify changes in paleoredox conditions, paleoproductivity, and clastic influx. From pyrolysis data, it is determined that Parasequence 1 potentially displays an increase in source rock potential, Parasequence 2 potentially displays a constant source rock potential, and Parasequences 3 and 4 potentially display overall decreases in source rock potential during deposition. From the inferred paleoredox conditions, paleoproductivity, and clastic influx, it is determined that Parasequence 1 experienced a potential increase in oxygen abundance, Parasequence 2 experienced a potential decrease in oxygen abundance, and Parasequences 3 and 4 potentially experienced increases in oxygen abundance during deposition. It is concluded that geochemical heterogeneities do exist on a bedding scale within the parasequences of the middle member of the Eagle Ford. Additional comprehensive sampling and analysis is recommended in the future in order to tie these data to subsurface data for economic application.

CATALOG OF MATERIALS AS POTENTIAL SOURCES OF INDOOR AIR EMISSIONS - VOLUME 1. INSULATION, WALLCOVERINGS, RESILIENT FLOOR COVERINGS, CARPET, ADHESIVES, SEALANTS AND CAULKS, AND PESTICIDES

EPA Science Inventory

The report discusses and presents data on constituents and emissions from products that have the potential to impact the indoor air environment. t is a tool to be used by researchers to help organize the study of materials as potential sources of indoor air emissions. ncluded are...

Nanocrystalline cellulose from coir fiber: preparation, properties, and applications

USDA-ARS?s Scientific Manuscript database

Nanocrystalline cellulose derived from various botanical sources offers unique and potentially useful characteristics. In principle, any cellulosic material can be considered as a potential source of a nanocrystalline material, including crops, crop residues, and agroindustrial wastes. Because of t...

Renewable Hydrogen Potential from Biogas in the United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saur, G.; Milbrandt, A.

This analysis updates and expands upon previous biogas studies to include total potential and net availability of methane in raw biogas with respect to competing demands and includes a resource assessment of four sources of biogas: (1) wastewater treatment plants, including domestic and a new assessment of industrial sources; (2) landfills; (3) animal manure; and (4) a new assessment of industrial, institutional, and commercial sources. The results of the biogas resource assessment are used to estimate the potential production of renewable hydrogen from biogas as well as the fuel cell electric vehicles that the produced hydrogen might support.

Inventory of drainage wells and potential sources of contaminants to drainage-well inflow in Southwest Orlando, Orange County, Florida

USGS Publications Warehouse

Taylor, George Fred

1993-01-01

Potential sources of contaminants that could pose a threat to drainage-well inflow and to water in the Floridan aquifer system in southwest Orlando, Florida, were studied between October and December 1990. Drainage wells and public-supply wells were inventoried in a 14-square-mile area, and available data on land use and activities within each drainage well basin were tabulated. Three public-supply wells (tapping the Lower Floridan aquifer) and 38 drainage wells (open to the Upper Floridan aquifer) were located in 17 drainage basins within the study area. The primary sources of drainage-well inflow are lake overflow, street runoff, seepage from the surficial aquifer system, and process-wastewater disposal. Drainage-well inflow from a variety of ares, including resi- dential, commercial, undeveloped, paved, and industrial areas, are potential sources of con- taminants. The four general types of possible contaminants to drainage-well inflow are inorganic chemicals, organic compounds, turbidity, and microbiological contaminants. Potential contami- nant sources include plant nurseries, citrus groves, parking lots, plating companies, auto- motive repair shops, and most commonly, lake- overflow water. Drainage wells provide a pathway for contaminants to enter the Upper Floridan aquifer and there is a potential for contaminants to move downward from the Upper Floridan to the Lower Floridan aquifer.

Determining the Depth of Infinite Horizontal Cylindrical Sources from Spontaneous Polarization Data

NASA Astrophysics Data System (ADS)

Cooper, G. R. J.; Stettler, E. H.

2017-03-01

Previously published semi-automatic interpretation methods that use ratios of analytic signal amplitudes of orders that differ by one to determine the distance to potential field sources are shown also to apply to self-potential (S.P.) data when the source is a horizontal cylinder. Local minima of the distance (when it becomes closest to zero) give the source depth. The method was applied to an S.P. anomaly from the Bourkes Luck potholes district in Mpumalanga Province, South Africa, and gave results that were confirmed by drilling.

Potential Sources of Polarized Light from a Plant Canopy

NASA Technical Reports Server (NTRS)

Vanderbilt, Vern; Daughtry, Craig; Dahlgren, Robert

2016-01-01

Field measurements have demonstrated that sunlight polarized during a first surface reflection by shiny leaves dominates the optical polarization of the light reflected by shiny-leafed plant canopies having approximately spherical leaf angle probability density functions ("Leaf Angle Distributions" - LAD). Yet for other canopies - specifically those without shiny leaves and/or spherical LADs - potential sources of optically polarized light may not always be obvious. Here we identify possible sources of polarized light within those other canopies and speculate on the ecologically important information polarization measurements of those sources might contain.

Expression of human telomerase reverse transcriptase protein in oral epithelial dysplasia and oral squamous cell carcinoma: An immunohistochemical study

PubMed Central

Raghunandan, Bangalore Nagarajachar; Sanjai, Karpagaselvi; Kumaraswamy, Jayalakshmi; Papaiah, Lokesh; Pandey, Bhavna; Jyothi, Bellur MadhavaRao

2016-01-01

Background: Telomerase is an RNA-dependent DNA polymerase that synthesizes TTAGGG telomeric DNA sequences and almost universally provides the molecular basis for unlimited proliferative potential. The telomeres become shorter with each cycle of replication and reach a critical limit; most cells die or enter stage of replicative senescence. Telomere length maintenance by telomerase is required for all the cells that exhibit limitless replicative potential. It has been postulated that reactivation of telomerase expression is necessary for the continuous proliferation of neoplastic cells to attain immortality. Use of immunohistochemistry (IHC) is a useful, reliable method of localizing the human telomerase reverse transcriptase (hTERT) protein in tissue sections which permits cellular localization. Although there exists a lot of information on telomerase in oral cancer, little is known about their expression in oral epithelial dysplasia and their progression to oral squamous cell carcinoma (OSCC) compared to normal oral mucosa. This study addresses this lacuna. Aims: To compare the expression of hTERT protein in oral epithelial dysplasia and OSCC with normal oral mucosa by Immunohistochemical method. Subjects and Methods: In this preliminary study, IHC was used to detect the expression of hTERT protein in OSCC (n = 20), oral epithelial dysplasia (n = 21) and normal oral mucosa (n = 10). The tissue localization of immunostain, cellular localization of immunostain, nature of stain, intensity of stain, percentage of cells stained with hTERT protein were studied. A total number of 100 cells were counted in each slide. Statistical Analysis: All the data were analyzed using SPSS software version 16.0. The tissue localization, cellular localization of cytoplasmic/nuclear/both of hTERT stain, staining intensity was compared across the groups using Pearson's Chi-square test. The mean percentage of cells stained for oral epithelial dysplasia, OSCC and normal oral mucosa were compared using analysis of variance (ANOVA). A P < 0.05 was considered to be statistically significant. Results: The mean hTERT positive cells in the study groups were as follows, 62.91% in normal oral mucosa samples, 77.06% in oral epithelial dysplasia cases, and 81.48% in OSCC. In 61.9% of oral epithelial dysplasia and 65% of OSCC in our study, staining was visualized within the nucleus predominantly in the dot like pattern. There was a statistically significant difference in the nature of nuclear stain between oral epithelial dysplasia and OSCC (P = 0.023). Conclusions: Our results suggests that the mean percentage of cells showing hTERT expression steadily increased from normal oral mucosa to oral epithelial dysplasia to OSCC. The steady trend of increase in the percentage of cells was evident in different grades of oral epithelial dysplasia group and OSCC. The nature of hTERT staining did show variations among the three groups and promise to be a potential surrogate marker for malignant transformation. Further studies using IHC on larger sample size and clinical follow-up of these patients will be ascertaining the full potential of hTERT as a surrogate marker of epithelial transformation. PMID:27194869

Current measuring system

DOEpatents

Dahl, David A.; Appelhans, Anthony D.; Olson, John E.

1997-01-01

A current measuring system comprising a current measuring device having a first electrode at ground potential, and a second electrode; a current source having an offset potential of at least three hundred volts, the current source having an output electrode; and a capacitor having a first electrode electrically connected to the output electrode of the current source and having a second electrode electrically connected to the second electrode of the current measuring device.

Differences in dissolved organic matter between reclaimed water source and drinking water source.

PubMed

Hu, Hong-Ying; Du, Ye; Wu, Qian-Yuan; Zhao, Xin; Tang, Xin; Chen, Zhuo

2016-05-01

Dissolved organic matter (DOM) significantly affects the quality of reclaimed water and drinking water. Reclaimed water potable reuse is an effective way to augment drinking water source and de facto reuse exists worldwide. Hence, when reclaimed water source (namely secondary effluent) is blended with drinking water source, understanding the difference in DOM between drinking water source (dDOM) and reclaimed water source (rDOM) is essential. In this study, composition, transformation, and potential risk of dDOM from drinking water source and rDOM from secondary effluent were compared. Generally, the DOC concentration of rDOM and dissolved organic nitrogen (DON) content in reclaimed water source were higher but rDOM exhibited a lower aromaticity. Besides, rDOM comprises a higher proportion of hydrophilic fractions and more low-molecular weight compounds, which are difficult to be removed during coagulation. Although dDOM exhibited higher specific disinfection byproducts formation potential (SDBPFP), rDOM formed more total disinfection byproducts (DBPs) during chlorination including halomethanes (THMs) and haloacetic acids (HAAs) due to high DOC concentration. Likewise, in consideration of DOC basis, rDOM contained more absolute assimilable organic carbon (AOC) despite showing a lower specific AOC (normalized AOC per unit of DOC). Besides, rDOM exhibited higher biotoxicity including genotoxicity and endocrine disruption. Therefore, rDOM presents a greater potential risk than dDOM does. Reclaimed water source needs to be treated carefully when it is blended with drinking water source. Copyright © 2015. Published by Elsevier B.V.

UNCERTAINTY IN LEACHING POTENTIAL OF NONPOINT SOURCE POLLUTANTS WITH APPLICATION TO GIS

EPA Science Inventory

This paper presents a stochastic framework for the assessment of groundwater pollution potential of nonpoint source pesticides. A conceptual relationship is presented that relates seasonally averaged groundwater recharge to soil properties and depths to the water table. The analy...

List of Potentially Affected Sources for the Asphalt Processing and Roofing Manufacturing National Emission Standards for Hazardous Air Pollutants (NESHAP) November 2001

EPA Pesticide Factsheets

This is a November 2001 list of sources identified by EPA as potentially affected by the Asphalt Processing and Roofing Manufacturing National Emission Standards for Hazardous Air Pollutants (NESHAP).

How to Manual: How to Update and Enhance Your Local Source Water Protection Assessments

EPA Pesticide Factsheets

Describes opportunities for improving source water assessments performed under the Safe Drinking Water Act 1453. It includes: local delineations, potential contaminant source inventories, and susceptibility determinations of source water assessment.

The accumulation of heavy metals in agricultural land and the associated potential ecological risks in Shenzhen, China.

PubMed

Wu, Jiansheng; Song, Jing; Li, Weifeng; Zheng, Maokun

2016-01-01

Accumulation of heavy metals in agricultural land and their ecological risks are key issues in soil security studies. This study investigated the concentrations of six heavy metals--copper (Cu), zinc (Zn), lead (Pb), nickel (Ni), and chromium (Cr) in Shenzhen's agricultural lands and examined the potential hazards and possible sources of these metals. Eighty-two samples from agricultural topsoil were collected. Potential ecological risk index was used to calculate the potential risk of heavy metals. Principal component analysis (PCA) was applied to explore pollution sources of the metals. Finally, Kriging was used to predict the spatial distribution of the metals' potential ecological risks. The concentrations of the heavy metals were higher than their background values. Most of them presented little potential ecological risk, except for the heavy metal cadmium (Cd). Four districts (Longgang, Longhua, Pingshan, and Dapeng) exhibited some degree of potential risk, which tended to have more industries and road networks. Three major sources of heavy metals included geochemical processes, industrial pollutants, and traffic pollution. The heavy metal Cd was the main contributor to the pollution in agricultural land during the study period. It also poses the potential hazard for the future. High potential risk is closely related to industrial pollution and transportation. Since the 1980s, the sources of heavy metals have evolved from parent rock weathering, erosion, degradation of organics, and mineralization to human disturbances resulting in chemical changes in the soil.

Contamination characteristics and source apportionment of trace metals in soils around Miyun Reservoir.

PubMed

Chen, Haiyang; Teng, Yanguo; Chen, Ruihui; Li, Jiao; Wang, Jinsheng

2016-08-01

Due to their toxicity and bioaccumulation, trace metals in soils can result in a wide range of toxic effects on animals, plants, microbes, and even humans. Recognizing the contamination characteristics of soil metals and especially apportioning their potential sources are the necessary preconditions for pollution prevention and control. Over the past decades, several receptor models have been developed for source apportionment. Among them, positive matrix factorization (PMF) has gained popularity and was recommended by the US Environmental Protection Agency as a general modeling tool. In this study, an extended chemometrics model, multivariate curve resolution-alternating least squares based on maximum likelihood principal component analysis (MCR-ALS/MLPCA), was proposed for source apportionment of soil metals and applied to identify the potential sources of trace metals in soils around Miyun Reservoir. Similar to PMF, the MCR-ALS/MLPCA model can incorporate measurement error information and non-negativity constraints in its calculation procedures. Model validation with synthetic dataset suggested that the MCR-ALS/MLPCA could extract acceptable recovered source profiles even considering relatively larger error levels. When applying to identify the sources of trace metals in soils around Miyun Reservoir, the MCR-ALS/MLPCA model obtained the highly similar profiles with PMF. On the other hand, the assessment results of contamination status showed that the soils around reservoir were polluted by trace metals in slightly moderate degree but potentially posed acceptable risks to the public. Mining activities, fertilizers and agrochemicals, and atmospheric deposition were identified as the potential anthropogenic sources with contributions of 24.8, 14.6, and 13.3 %, respectively. In order to protect the drinking water source of Beijing, special attention should be paid to the metal inputs to soils from mining and agricultural activities.

Next-generation mid-infrared sources

NASA Astrophysics Data System (ADS)

Jung, D.; Bank, S.; Lee, M. L.; Wasserman, D.

2017-12-01

The mid-infrared (mid-IR) is a wavelength range with a variety of technologically vital applications in molecular sensing, security and defense, energy conservation, and potentially in free-space communication. The recent development and rapid commercialization of new coherent mid-infrared sources have spurred significant interest in the development of mid-infrared optical systems for the above applications. However, optical systems designers still do not have the extensive optical infrastructure available to them that exists at shorter wavelengths (for instance, in the visible and near-IR/telecom wavelengths). Even in the field of optoelectronic sources, which has largely driven the growing interest in the mid-infrared, the inherent limitations of state-of-the-art sources and the gaps in spectral coverage offer opportunities for the development of new classes of lasers, light emitting diodes and emitters for a range of potential applications. In this topical review, we will first present an overview of the current state-of-the-art mid-IR sources, in particular thermal emitters, which have long been utilized, and the relatively new quantum- and interband-cascade lasers, as well as the applications served by these sources. Subsequently, we will discuss potential mid-infrared applications and wavelength ranges which are poorly served by the current stable of mid-IR sources, with an emphasis on understanding the fundamental limitations of the current source technology. The bulk of the manuscript will then explore both past and recent developments in mid-infrared source technology, including narrow bandgap quantum well lasers, type-I and type-II quantum dot materials, type-II superlattices, highly mismatched alloys, lead-salts and transition-metal-doped II-VI materials. We will discuss both the advantages and limitations of each of the above material systems, as well as the potential new applications which they might serve. All in all, this topical review does not aim to provide a survey of the current state of the art for mid-IR sources, but instead looks primarily to provide a picture of potential next-generation optical and optoelectronic materials systems for mid-IR light generation.

Sediment sources in a small agricultural catchment: A composite fingerprinting approach based on the selection of potential sources

NASA Astrophysics Data System (ADS)

Zhou, Huiping; Chang, Weina; Zhang, Longjiang

2016-08-01

Fingerprinting techniques have been widely used as a reasonable and reliable means for investigating sediment sources, especially in relatively large catchments in which there are significant differences in surface materials. However, the discrimination power of fingerprint properties for small catchments, in which the surface materials are relatively homogeneous and human interference is marked, may be affected by fragmentary or confused source information. Using fingerprinting techniques can be difficult, and there is still a need for further studies to verify the effectiveness of such techniques in these small catchments. A composite fingerprinting approach was used in this study to investigate the main sources of sediment output, as well as their relative contributions, from a small catchment (30 km2) with high levels of farming and mining activities. The impact of the selection of different potential sediment sources on the derivation of composite fingerprints and its discrimination power were also investigated by comparing the results from different combinations of potential source types. The initial source types and several samples that could cause confusion were adjusted. These adjustments improved the discrimination power of the composite fingerprints. The results showed that the composite fingerprinting approach used in this study had a discriminatory efficiency of 89.2% for different sediment sources and that the model had a mean goodness of fit of 0.90. Cultivated lands were the main sediment source. The sediment contribution of the studied cultivated lands ranged from 39.9% to 87.8%, with a mean of 76.6%, for multiple deposited sediment samples. The mean contribution of woodlands was 21.7%. Overall, the sediment contribution from mining and road areas was relatively low. The selection of potential sources is an important factor in the application of fingerprinting techniques and warrants more attention in future studies, as is the case with other uncertainty factors.

An integrated approach to evaluate the Aji-Chai potash resources in Iran using potential field data

NASA Astrophysics Data System (ADS)

Abedi, Maysam

2018-03-01

This work presents an integrated application of potential field data to discover potash-bearing evaporite sources in Aji-Chai salt deposit, located in east Azerbaijan province, northwest of Iran. Low density and diamagnetic effect of salt minerals, i.e. potash, give rise to promising potential field anomalies that assist to localize sought blind targets. The halokinetic-type potash-bearing salts in the prospect zone have flowed upward and intruded into surrounded sedimentary sequences dominated frequently by marl, gypsum and alluvium terraces. Processed gravity and magnetic data delineated a main potash source with negative gravity and magnetic amplitude responses. To better visualize these evaporite deposits, 3D model of density contrast and magnetic susceptibility was constructed through constrained inversion of potential field data. A mixed-norm regularization technique was taken into account to generate sharp and compact geophysical models. Since tectonic pressure causes vertical movement of the potash in the studied region, a simple vertical cylindrical shape is an appropriate geometry to simulate these geological targets. Therefore, structural index (i.e. decay rate of potential field amplitude with distance) of such assumed source was embedded in the inversion program as a geometrical constraint to image these geologically plausible sources. In addition, the top depth of the main and the adjacent sources were estimated 39 m and 22 m, respectively, via the combination of the analytic signal and the Euler deconvolution techniques. Drilling result also indicated that the main source of potash starts at a depth of 38 m. The 3D models of the density contrast and the magnetic susceptibility (assuming a superficial sedimentary cover as a hard constraint in the inversion algorithm) demonstrated that potash source has an extension in depth less than 150 m.

CATALOG OF MATERIALS AS POTENTIAL SOURCES OF INDOOR AIR EMISSIONS - VOLUME 1. INSULATION, WALLCOVERINGS, RESI- LIENT FLOOR COVERINGS, CARPET, ADHESIVES, SEALANTS AND CAULKS, AND PESTICIDES

EPA Science Inventory

The report discusses and presents data on constituents and emissions from products that have the potential to impact the indoor air environment. t is a tool to be used by researchers to help organize the study of materials as potential sources of indoor air emissions. ncluded are...

Psychrometric Measurement of Leaf Water Potential: Lack of Error Attributable to Leaf Permeability.

PubMed

Barrs, H D

1965-07-02

A report that low permeability could cause gross errors in psychrometric determinations of water potential in leaves has not been confirmed. No measurable error from this source could be detected for either of two types of thermocouple psychrometer tested on four species, each at four levels of water potential. No source of error other than tissue respiration could be demonstrated.

Potential profile near singularity point in kinetic Tonks-Langmuir discharges as a function of the ion sources temperature

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kos, L.; Tskhakaya, D. D.; Jelic, N.

2011-05-15

A plasma-sheath transition analysis requires a reliable mathematical expression for the plasma potential profile {Phi}(x) near the sheath edge x{sub s} in the limit {epsilon}{identical_to}{lambda}{sub D}/l=0 (where {lambda}{sub D} is the Debye length and l is a proper characteristic length of the discharge). Such expressions have been explicitly calculated for the fluid model and the singular (cold ion source) kinetic model, where exact analytic solutions for plasma equation ({epsilon}=0) are known, but not for the regular (warm ion source) kinetic model, where no analytic solution of the plasma equation has ever been obtained. For the latter case, Riemann [J. Phys.more » D: Appl. Phys. 24, 493 (1991)] only predicted a general formula assuming relatively high ion-source temperatures, i.e., much higher than the plasma-sheath potential drop. Riemann's formula, however, according to him, never was confirmed in explicit solutions of particular models (e.g., that of Bissell and Johnson [Phys. Fluids 30, 779 (1987)] and Scheuer and Emmert [Phys. Fluids 31, 3645 (1988)]) since ''the accuracy of the classical solutions is not sufficient to analyze the sheath vicinity''[Riemann, in Proceedings of the 62nd Annual Gaseous Electronic Conference, APS Meeting Abstracts, Vol. 54 (APS, 2009)]. Therefore, for many years, there has been a need for explicit calculation that might confirm the Riemann's general formula regarding the potential profile at the sheath edge in the cases of regular very warm ion sources. Fortunately, now we are able to achieve a very high accuracy of results [see, e.g., Kos et al., Phys. Plasmas 16, 093503 (2009)]. We perform this task by using both the analytic and the numerical method with explicit Maxwellian and ''water-bag'' ion source velocity distributions. We find the potential profile near the plasma-sheath edge in the whole range of ion source temperatures of general interest to plasma physics, from zero to ''practical infinity.'' While within limits of ''very low'' and ''relatively high'' ion source temperatures, the potential is proportional to the space coordinate powered by rational numbers {alpha}=1/2 and {alpha}=2/3, with medium ion source temperatures. We found {alpha} between these values being a non-rational number strongly dependent on the ion source temperature. The range of the non-rational power-law turns out to be a very narrow one, at the expense of the extension of {alpha}=2/3 region towards unexpectedly low ion source temperatures.« less

A slow positron beam generator for lifetime studies

NASA Technical Reports Server (NTRS)

Singh, Jag J.; Eftekhari, Abe; St.clair, Terry L.

1989-01-01

A slow positron beam generator using well-annealed polycrystalline tungsten moderators and a Na-22 positron source was developed. A 250 micro c source, deposited on a 2.54 micron thick aluminized mylar, is sandwiched between two (2.54 cm x 2.54 cm x 0.0127 cm) tungsten pieces. Two (2.54 cm x 2.54 cm x t cm) test polymer films insulate the two tungsten moderator pieces from the aluminized mylar source holder (t=0.00127 to 0.0127). A potential difference of 10 to 100 volts--depending on the test polymer film thickness (t)--is applied between the tungsten pieces and the source foil. Thermalized positrons diffusing out of the moderator pieces are attracted to the source foil held at an appropriate potential below the moderator pieces. These positrons have to pass through the test polymer films before they can reach the source foil. The potential difference between the moderator pieces and the aluminized mylar is so adjusted as to force the positrons to stop in the test polymer films. Thus the new generator becomes an effective source of positrons for assaying thin polymer films for their molecular morphology.

UNCERTAINTY IN LEACHING POTENTIAL OF NONPOINT SOURCE POLLUTANTS WITH APPLICATION TO A GIS

EPA Science Inventory

This paper presents a stochastic framework for the assessment of groundwater pollution potential of nonpoint source pesticides. A conceptual relationship is presented that relates seasonally averaged groundwater recharge to soil properties and depths to the water table. The analy...

Potential Energy Sources Pose Mining Problem

ERIC Educational Resources Information Center

Chemical and Engineering News, 1974

1974-01-01

Summarizes the discussions of a Division of Industrial and Engineering Chemistry symposium on solids handling for synthetic fuels production. Included is a description of technical difficulties with the use of coal seams and deposits of oil shale and oil sand as potential sources of fuel. (CC)

Induced pluripotent stem cells (iPSCs) derived from different cell sources and their potential for regenerative and personalized medicine.

PubMed

Shtrichman, R; Germanguz, I; Itskovitz-Eldor, J

2013-06-01

Human induced pluripotent stem cells (hiPSCs) have great potential as a robust source of progenitors for regenerative medicine. The novel technology also enables the derivation of patient-specific cells for applications to personalized medicine, such as for personal drug screening and toxicology. However, the biological characteristics of iPSCs are not yet fully understood and their similarity to human embryonic stem cells (hESCs) is still unresolved. Variations among iPSCs, resulting from their original tissue or cell source, and from the experimental protocols used for their derivation, significantly affect epigenetic properties and differentiation potential. Here we review the potential of iPSCs for regenerative and personalized medicine, and assess their expression pattern, epigenetic memory and differentiation capabilities in relation to their parental tissue source. We also summarize the patient-specific iPSCs that have been derived for applications in biological research and drug discovery; and review risks that must be overcome in order to use iPSC technology for clinical applications.

Database of potential sources for earthquakes larger than magnitude 6 in Northern California

USGS Publications Warehouse

,

1996-01-01

The Northern California Earthquake Potential (NCEP) working group, composed of many contributors and reviewers in industry, academia and government, has pooled its collective expertise and knowledge of regional tectonics to identify potential sources of large earthquakes in northern California. We have created a map and database of active faults, both surficial and buried, that forms the basis for the northern California portion of the national map of probabilistic seismic hazard. The database contains 62 potential sources, including fault segments and areally distributed zones. The working group has integrated constraints from broadly based plate tectonic and VLBI models with local geologic slip rates, geodetic strain rate, and microseismicity. Our earthquake source database derives from a scientific consensus that accounts for conflict in the diverse data. Our preliminary product, as described in this report brings to light many gaps in the data, including a need for better information on the proportion of deformation in fault systems that is aseismic.

Potential sources of precipitation in Lake Baikal basin

NASA Astrophysics Data System (ADS)

Shukurov, K. A.; Mokhov, I. I.

2017-11-01

Based on the data of long-term measurements at 23 meteorological stations in the Russian part of the Lake Baikal basin the probabilities of daily precipitation with different intensity and their contribution to the total precipitation are estimated. Using the trajectory model HYSPLIT_4 for each meteorological station for the period 1948-2016 the 10-day backward trajectories of air parcels, the height of these trajectories and distribution of specific humidity along the trajectories are calculated. The average field of power of potential sources of daily precipitation (less than 10 mm) for all meteorological stations in the Russian part of the Lake Baikal basin was obtained using the CWT (concentration weighted trajectory) method. The areas have been identified from which within 10 days water vapor can be transported to the Lake Baikal basin, as well as regions of the most and least powerful potential sources. The fields of the mean height of air parcels trajectories and the mean specific humidity along the trajectories are compared with the field of mean power of potential sources.

Current measuring system

DOEpatents

Dahl, D.A.; Appelhans, A.D.; Olson, J.E.

1997-09-09

A current measuring system is disclosed comprising a current measuring device having a first electrode at ground potential, and a second electrode; a current source having an offset potential of at least three hundred volts, the current source having an output electrode; and a capacitor having a first electrode electrically connected to the output electrode of the current source and having a second electrode electrically connected to the second electrode of the current measuring device. 4 figs.

Adult subventricular zone neural stem cells as a potential source of dopaminergic replacement neurons

PubMed Central

Cave, John W.; Wang, Meng; Baker, Harriet

2014-01-01

Clinical trials engrafting human fetal ventral mesencephalic tissue have demonstrated, in principle, that cell replacement therapy provides substantial long-lasting improvement of motor impairments generated by Parkinson's Disease (PD). The use of fetal tissue is not practical for widespread clinical implementation of this therapy, but stem cells are a promising alternative source for obtaining replacement cells. The ideal stem cell source has yet to be established and, in this review, we discuss the potential of neural stem cells in the adult subventricular zone (SVZ) as an autologous source of replacement cells. We identify three key challenges for further developing this potential source of replacement cells: (1) improving survival of transplanted cells, (2) suppressing glial progenitor proliferation and survival, and (3) developing methods to efficiently produce dopaminergic neurons. Subventricular neural stem cells naturally produce a dopaminergic interneuron phenotype that has an apparent lack of vulnerability to PD-mediated degeneration. We also discuss whether olfactory bulb dopaminergic neurons derived from adult SVZ neural stem cells are a suitable source for cell replacement strategies. PMID:24574954

Source apportionment of the carcinogenic potential of polycyclic aromatic hydrocarbons (PAH) associated to airborne PM10 by a PMF model.

PubMed

Callén, M S; Iturmendi, A; López, J M; Mastral, A M

2014-02-01

In order to perform a study of the carcinogenic potential of polycyclic aromatic hydrocarbons (PAH), benzo(a)pyrene equivalent (BaP-eq) concentration was calculated and modelled by a receptor model based on positive matrix factorization (PMF). Nineteen PAH associated to airborne PM10 of Zaragoza, Spain, were quantified during the sampling period 2001-2009 and used as potential variables by the PMF model. Afterwards, multiple linear regression analysis was used to quantify the potential sources of BaP-eq. Five sources were obtained as the optimal solution and vehicular emission was identified as the main carcinogenic source (35 %) followed by heavy-duty vehicles (28 %), light-oil combustion (18 %), natural gas (10 %) and coal combustion (9 %). Two of the most prevailing directions contributing to this carcinogenic character were the NE and N directions associated with a highway, industrial parks and a paper factory. The lifetime lung cancer risk exceeded the unit risk of 8.7 x 10(-5) per ng/m(3) BaP in both winter and autumn seasons and the most contributing source was the vehicular emission factor becoming an important issue in control strategies.

Littoral lichens as a novel source of potentially bioactive Actinobacteria.

PubMed

Parrot, Delphine; Antony-Babu, Sanjay; Intertaglia, Laurent; Grube, Martin; Tomasi, Sophie; Suzuki, Marcelino T

2015-10-30

Cultivable Actinobacteria are the largest source of microbially derived bioactive molecules. The high demand for novel antibiotics highlights the need for exploring novel sources of these bacteria. Microbial symbioses with sessile macro-organisms, known to contain bioactive compounds likely of bacterial origin, represent an interesting and underexplored source of Actinobacteria. We studied the diversity and potential for bioactive-metabolite production of Actinobacteria associated with two marine lichens (Lichina confinis and L. pygmaea; from intertidal and subtidal zones) and one littoral lichen (Roccella fuciformis; from supratidal zone) from the Brittany coast (France), as well as the terrestrial lichen Collema auriforme (from a riparian zone, Austria). A total of 247 bacterial strains were isolated using two selective media. Isolates were identified and clustered into 101 OTUs (98% identity) including 51 actinobacterial OTUs. The actinobacterial families observed were: Brevibacteriaceae, Cellulomonadaceae, Gordoniaceae, Micrococcaceae, Mycobacteriaceae, Nocardioidaceae, Promicromonosporaceae, Pseudonocardiaceae, Sanguibacteraceae and Streptomycetaceae. Interestingly, the diversity was most influenced by the selective media rather than lichen species or the level of lichen thallus association. The potential for bioactive-metabolite biosynthesis of the isolates was confirmed by screening genes coding for polyketide synthases types I and II. These results show that littoral lichens are a source of diverse potentially bioactive Actinobacteria.

Littoral lichens as a novel source of potentially bioactive Actinobacteria

PubMed Central

Parrot, Delphine; Antony-Babu, Sanjay; Intertaglia, Laurent; Grube, Martin; Tomasi, Sophie; Suzuki, Marcelino T.

2015-01-01

Cultivable Actinobacteria are the largest source of microbially derived bioactive molecules. The high demand for novel antibiotics highlights the need for exploring novel sources of these bacteria. Microbial symbioses with sessile macro-organisms, known to contain bioactive compounds likely of bacterial origin, represent an interesting and underexplored source of Actinobacteria. We studied the diversity and potential for bioactive-metabolite production of Actinobacteria associated with two marine lichens (Lichina confinis and L. pygmaea; from intertidal and subtidal zones) and one littoral lichen (Roccella fuciformis; from supratidal zone) from the Brittany coast (France), as well as the terrestrial lichen Collema auriforme (from a riparian zone, Austria). A total of 247 bacterial strains were isolated using two selective media. Isolates were identified and clustered into 101 OTUs (98% identity) including 51 actinobacterial OTUs. The actinobacterial families observed were: Brevibacteriaceae, Cellulomonadaceae, Gordoniaceae, Micrococcaceae, Mycobacteriaceae, Nocardioidaceae, Promicromonosporaceae, Pseudonocardiaceae, Sanguibacteraceae and Streptomycetaceae. Interestingly, the diversity was most influenced by the selective media rather than lichen species or the level of lichen thallus association. The potential for bioactive-metabolite biosynthesis of the isolates was confirmed by screening genes coding for polyketide synthases types I and II. These results show that littoral lichens are a source of diverse potentially bioactive Actinobacteria. PMID:26514347

Device and methods for writing and erasing analog information in small memory units via voltage pulses

DOEpatents

El Gabaly Marquez, Farid; Talin, Albert Alec

2018-04-17

Devices and methods for non-volatile analog data storage are described herein. In an exemplary embodiment, an analog memory device comprises a potential-carrier source layer, a barrier layer deposited on the source layer, and at least two storage layers deposited on the barrier layer. The memory device can be prepared to write and read data via application of a biasing voltage between the source layer and the storage layers, wherein the biasing voltage causes potential-carriers to migrate into the storage layers. After initialization, data can be written to the memory device by application of a voltage pulse between two storage layers that causes potential-carriers to migrate from one storage layer to another. A difference in concentration of potential carriers caused by migration of potential-carriers between the storage layers results in a voltage that can be measured in order to read the written data.

Human Health Risk Implications of Multiple Sources of Faecal Indicator Bacteria in a Recreational Waterbody

EPA Science Inventory

We evaluate the influence of multiple sources of faecal indicator bacteria in recreational water bodies on potential human health risk by considering waters impacted by human and animal sources, human and non-pathogenic sources, and animal and non-pathogenic sources. We illustrat...

Assessment of source probabilities for potential tsunamis affecting the U.S. Atlantic coast

USGS Publications Warehouse

Geist, E.L.; Parsons, T.

2009-01-01

Estimating the likelihood of tsunamis occurring along the U.S. Atlantic coast critically depends on knowledge of tsunami source probability. We review available information on both earthquake and landslide probabilities from potential sources that could generate local and transoceanic tsunamis. Estimating source probability includes defining both size and recurrence distributions for earthquakes and landslides. For the former distribution, source sizes are often distributed according to a truncated or tapered power-law relationship. For the latter distribution, sources are often assumed to occur in time according to a Poisson process, simplifying the way tsunami probabilities from individual sources can be aggregated. For the U.S. Atlantic coast, earthquake tsunami sources primarily occur at transoceanic distances along plate boundary faults. Probabilities for these sources are constrained from previous statistical studies of global seismicity for similar plate boundary types. In contrast, there is presently little information constraining landslide probabilities that may generate local tsunamis. Though there is significant uncertainty in tsunami source probabilities for the Atlantic, results from this study yield a comparative analysis of tsunami source recurrence rates that can form the basis for future probabilistic analyses.

Rediscovering Acetate Metabolism: Its Potential Sources and Utilization for Biobased Transformation into Value-Added Chemicals.

PubMed

Lim, Hyun Gyu; Lee, Ji Hoon; Noh, Myung Hyun; Jung, Gyoo Yeol

2018-04-25

One of the great advantages of microbial fermentation is the capacity to convert various carbon compounds into value-added chemicals. In this regard, there have been many efforts to engineer microorganisms to facilitate utilization of abundant carbon sources. Recently, the potential of acetate as a feedstock has been discovered; efforts have been made to produce various biochemicals from acetate based on understanding of its metabolism. In this review, we discuss the potential sources of acetate and summarized the recent progress to improve acetate utilization with microorganisms. Furthermore, we also describe representative studies that engineered microorganisms for the production of biochemicals from acetate.

Improved estimation of sediment source contributions by concentration-dependent Bayesian isotopic mixing model

NASA Astrophysics Data System (ADS)

Ram Upadhayay, Hari; Bodé, Samuel; Griepentrog, Marco; Bajracharya, Roshan Man; Blake, Will; Cornelis, Wim; Boeckx, Pascal

2017-04-01

The implementation of compound-specific stable isotope (CSSI) analyses of biotracers (e.g. fatty acids, FAs) as constraints on sediment-source contributions has become increasingly relevant to understand the origin of sediments in catchments. The CSSI fingerprinting of sediment utilizes CSSI signature of biotracer as input in an isotopic mixing model (IMM) to apportion source soil contributions. So far source studies relied on the linear mixing assumptions of CSSI signature of sources to the sediment without accounting for potential effects of source biotracer concentration. Here we evaluated the effect of FAs concentration in sources on the accuracy of source contribution estimations in artificial soil mixture of three well-separated land use sources. Soil samples from land use sources were mixed to create three groups of artificial mixture with known source contributions. Sources and artificial mixture were analysed for δ13C of FAs using gas chromatography-combustion-isotope ratio mass spectrometry. The source contributions to the mixture were estimated using with and without concentration-dependent MixSIAR, a Bayesian isotopic mixing model. The concentration-dependent MixSIAR provided the closest estimates to the known artificial mixture source contributions (mean absolute error, MAE = 10.9%, and standard error, SE = 1.4%). In contrast, the concentration-independent MixSIAR with post mixing correction of tracer proportions based on aggregated concentration of FAs of sources biased the source contributions (MAE = 22.0%, SE = 3.4%). This study highlights the importance of accounting the potential effect of a source FA concentration for isotopic mixing in sediments that adds realisms to mixing model and allows more accurate estimates of contributions of sources to the mixture. The potential influence of FA concentration on CSSI signature of sediments is an important underlying factor that determines whether the isotopic signature of a given source is observable even after equilibrium. Therefore inclusion of FA concentrations of the sources in the IMM formulation is standard procedure for accurate estimation of source contributions. The post model correction approach that dominates the CSSI fingerprinting causes bias, especially if the FAs concentration of sources differs substantially.

Net global warming potential and greenhouse gas intensity

USDA-ARS?s Scientific Manuscript database

Various methods exist to calculate global warming potential (GWP) and greenhouse gas intensity (GHG) as measures of net greenhouse gas (GHG) emissions from agroecosystems. Little is, however, known about net GWP and GHGI that account for all sources and sinks of GHG emissions. Sources of GHG include...

EPA’s Study of Potential Impacts of Hydraulic Fracturing on Drinking Water Resources: Wastewater Source Apportionment Project

EPA Pesticide Factsheets

EPA scientists evaluated sources of bromide and other inorganic pollutants impacting drinking water intakes on the Allegheny River in Pennsylvania to examine the potential impacts related to the treatment and disposal of oil & gas well produced wastewater.

The art of designing markets.

PubMed

Roth, Alvin E

2007-10-01

Traditionally, markets have been viewed as simply the confluence of supply and demand. But to function properly, they must be able to attract a sufficient number of buyers and sellers, induce participants to make their preferences clear, and overcome congestion by providing both enough time to make choices and a speedy means of registering them. Solutions to these challenges are the province of market design--a blend of game theory and experimental economics. Roth, a professor of both business and economics at Harvard, is a leading market designer. He and his colleagues have rescued failing markets by, for example, designing labor clearinghouses through which U.S. doctors get their first jobs and auctions through which the Federal Communications Commission sells licenses for parts of the radio broadcast spectrum. They have also created marketlike allocation procedures that involve neither prices nor an exchange of money; these include systems for assigning children to schools in Boston and New York and for facilitating exchanges of kidneys. Computers enable the design of "smart markets" that combine the inputs of users in complex ways: In kidney exchange, they run through every possible match of donors and recipients to arrange the greatest possible number of transplants. In the future, computers may make it possible to auction bundled goods, such as airport takeoff and landing slots. As online markets--like those for jobs and dating--proliferate, a growing understanding of markets in general will provide virtually limitless opportunities for market design.

How high do ion fluxes go? A re-evaluation of the two-mechanism model of K(+) transport in plant roots.

PubMed

Coskun, Devrim; Britto, Dev T; Kochian, Leon V; Kronzucker, Herbert J

2016-02-01

Potassium (K(+)) acquisition in roots is generally described by a two-mechanism model, consisting of a saturable, high-affinity transport system (HATS) operating via H(+)/K(+) symport at low (<1mM) external [K(+)] ([K(+)]ext), and a linear, low-affinity system (LATS) operating via ion channels at high (>1mM) [K(+)]ext. Radiotracer measurements in the LATS range indicate that the linear rise in influx continues well beyond nutritionally relevant concentrations (>10mM), suggesting K(+) transport may be pushed to extraordinary, and seemingly limitless, capacity. Here, we assess this rise, asking whether LATS measurements faithfully report transmembrane fluxes. Using (42)K(+)-isotope and electrophysiological methods in barley, we show that this flux is part of a K(+)-transport cycle through the apoplast, and masks a genuine plasma-membrane influx that displays Michaelis-Menten kinetics. Rapid apoplastic cycling of K(+) is corroborated by an absence of transmembrane (42)K(+) efflux above 1mM, and by the efflux kinetics of PTS, an apoplastic tracer. A linear apoplastic influx, masking a saturating transmembrane influx, was also found in Arabidopsis mutants lacking the K(+) transporters AtHAK5 and AtAKT1. Our work significantly revises the model of K(+) transport by demonstrating a surprisingly modest upper limit for plasma-membrane influx, and offers insight into sodium transport under salt stress. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Computational Modeling Develops Ultra-Hard Steel

NASA Technical Reports Server (NTRS)

2007-01-01

Glenn Research Center's Mechanical Components Branch developed a spiral bevel or face gear test rig for testing thermal behavior, surface fatigue, strain, vibration, and noise; a full-scale, 500-horsepower helicopter main-rotor transmission testing stand; a gear rig that allows fundamental studies of the dynamic behavior of gear systems and gear noise; and a high-speed helical gear test for analyzing thermal behavior for rotorcraft. The test rig provides accelerated fatigue life testing for standard spur gears at speeds of up to 10,000 rotations per minute. The test rig enables engineers to investigate the effects of materials, heat treat, shot peen, lubricants, and other factors on the gear's performance. QuesTek Innovations LLC, based in Evanston, Illinois, recently developed a carburized, martensitic gear steel with an ultra-hard case using its computational design methodology, but needed to verify surface fatigue, lifecycle performance, and overall reliability. The Battelle Memorial Institute introduced the company to researchers at Glenn's Mechanical Components Branch and facilitated a partnership allowing researchers at the NASA Center to conduct spur gear fatigue testing for the company. Testing revealed that QuesTek's gear steel outperforms the current state-of-the-art alloys used for aviation gears in contact fatigue by almost 300 percent. With the confidence and credibility provided by the NASA testing, QuesTek is commercializing two new steel alloys. Uses for this new class of steel are limitless in areas that demand exceptional strength for high throughput applications.

Predicting hydrologic function with the streamwater mircobiome

NASA Astrophysics Data System (ADS)

Good, S. P.; URycki, D. R.; Crump, B. C.

2017-12-01

Recent advances in microbiology allow for rapid and cost-effective determination of the presence of a nearly limitless number of bacterial (and other) species within a water sample. Here, we posit that the quasi-unique taxonomic composition of the aquatic microbiome is an emergent property of a catchment that contains information about hydrologic function at multiple temporal and spatial scales, and term this approach `genohydrolgy.' As first a genohydrology case study, we show that the relative abundance of bacterial species within different operational taxonomic units (OTUs) from six large arctic rivers can be used to predict river discharge at monthly and longer timescales. Using only OTU abundance information and a machine-learning algorithm trained on OTU and discharge data from the other five rivers, our genohydrology approach is able to predict mean monthly discharge values throughout the year with an average Nash-Sutcliffe efficiency (NSE) of 0.50, while the recurrence interval of extreme flows at longer times scales in these rivers was predicted with an NSE of 0.04. This approach demonstrates considerable improvement over prediction of these quantities in each river based only on discharge data from the other five (our null hypothesis), which had average NSE values of -1.19 and -5.50 for the seasonal and recurrence interval discharge values, respectively. Overall the genohydrology approach demonstrates that bacterial diversity within the aquatic microbiome is a large and underutilized data resource with benefits for prediction of hydrologic function.

Numerical evaluation of longitudinal motions of Wigley hulls advancing in waves by using Bessho form translating-pulsating source Green'S function

NASA Astrophysics Data System (ADS)

Xiao, Wenbin; Dong, Wencai

2016-06-01

In the framework of 3D potential flow theory, Bessho form translating-pulsating source Green's function in frequency domain is chosen as the integral kernel in this study and hybrid source-and-dipole distribution model of the boundary element method is applied to directly solve the velocity potential for advancing ship in regular waves. Numerical characteristics of the Green function show that the contribution of local-flow components to velocity potential is concentrated at the nearby source point area and the wave component dominates the magnitude of velocity potential in the far field. Two kinds of mathematical models, with or without local-flow components taken into account, are adopted to numerically calculate the longitudinal motions of Wigley hulls, which demonstrates the applicability of translating-pulsating source Green's function method for various ship forms. In addition, the mesh analysis of discrete surface is carried out from the perspective of ship-form characteristics. The study shows that the longitudinal motion results by the simplified model are somewhat greater than the experimental data in the resonant zone, and the model can be used as an effective tool to predict ship seakeeping properties. However, translating-pulsating source Green function method is only appropriate for the qualitative analysis of motion response in waves if the ship geometrical shape fails to satisfy the slender-body assumption.

[Animals as a potential source of human fungal infections].

PubMed

Dworecka-Kaszak, Bozena

2008-01-01

Changing environment is a reason, that many saprotrophic fungi became opportunists and in the end also maybe a pathogenic. Host specific adaptation is not so strong among fungi, so there are many common fungal pathogens for people and for animals. Animals suffering from dermatomycosis are well recognize as source of human superficial mycoses. Breeding of different exotic animals such as parrots, various Reptiles and Amphibians, miniature Rodents and keeping them as a pets in the peoples houses, have become more and more popular in the recent years. This article is shortly presenting which animals maybe a potential source of fungal infections for humans. Looking for the other mycoses as systemic mycoses, especially candidiasis or aspergilosis there are no data, which allow excluding sick animals as a source of infection for human, even if those deep mycoses have endogenic reactivation mechanism. Immunocompromised people are in high-risk group when they take care of animals. Another important source of potentially pathogenic, mostly air-born fungi may be animal use in experimental laboratory work. During the experiments is possible that laboratory workers maybe hurt and these animals and their environment, food and house boxes could be the possible source of microorganisms, pathogenic for humans or other animals. Unusual way to inoculate these potentially pathogens into the skin of laboratory personnel may cause granulomatous, local lesions on their hands.

Do forests represent a long-term source of contaminated particulate matter in the Fukushima Prefecture?

PubMed

Laceby, J Patrick; Huon, Sylvain; Onda, Yuichi; Vaury, Veronique; Evrard, Olivier

2016-12-01

The Fukushima Daiichi Nuclear Power Plant (FDNPP) accident resulted in radiocesium fallout contaminating coastal catchments of the Fukushima Prefecture. As the decontamination effort progresses, the potential downstream migration of radiocesium contaminated particulate matter from forests, which cover over 65% of the most contaminated region, requires investigation. Carbon and nitrogen elemental concentrations and stable isotope ratios are thus used to model the relative contributions of forest, cultivated and subsoil sources to deposited particulate matter in three contaminated coastal catchments. Samples were taken from the main identified sources: cultivated (n = 28), forest (n = 46), and subsoils (n = 25). Deposited particulate matter (n = 82) was sampled during four fieldwork campaigns from November 2012 to November 2014. A distribution modelling approach quantified relative source contributions with multiple combinations of element parameters (carbon only, nitrogen only, and four parameters) for two particle size fractions (<63 μm and <2 mm). Although there was significant particle size enrichment for the particulate matter parameters, these differences only resulted in a 6% (SD 3%) mean difference in relative source contributions. Further, the three different modelling approaches only resulted in a 4% (SD 3%) difference between relative source contributions. For each particulate matter sample, six models (i.e. <63 μm and <2 mm from the three modelling approaches) were used to incorporate a broader definition of potential uncertainty into model results. Forest sources were modelled to contribute 17% (SD 10%) of particulate matter indicating they present a long term potential source of radiocesium contaminated material in fallout impacted catchments. Subsoils contributed 45% (SD 26%) of particulate matter and cultivated sources contributed 38% (SD 19%). The reservoir of radiocesium in forested landscapes in the Fukushima region represents a potential long-term source of particulate contaminated matter that will require diligent management for the foreseeable future. Copyright © 2016 Elsevier Ltd. All rights reserved.

Partnerships To Mine Unexploited Sources of Metadata.

ERIC Educational Resources Information Center

Reynolds, Regina Romano

This paper discusses the metadata created for other purposes as a potential source of bibliographic data. The first section addresses collecting metadata by means of templates, including the Nordic Metadata Project's Dublin Core Metadata Template. The second section considers potential partnerships for re-purposing metadata for bibliographic use,…

75 FR 67983 - Agency Information Collection Activities; Announcement of Office of Management and Budget...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-04

...] Agency Information Collection Activities; Announcement of Office of Management and Budget Approval; Evaluation of Potential Data Sources for the Sentinel Initiative AGENCY: Food and Drug Administration, HHS... information entitled ``Evaluation of Potential Data Sources for the Sentinel Initiative'' has been approved by...

Hidden Item Variance in Multiple Mini-Interview Scores

ERIC Educational Resources Information Center

Zaidi, Nikki L.; Swoboda, Christopher M.; Kelcey, Benjamin M.; Manuel, R. Stephen

2017-01-01

The extant literature has largely ignored a potentially significant source of variance in multiple mini-interview (MMI) scores by "hiding" the variance attributable to the sample of attributes used on an evaluation form. This potential source of hidden variance can be defined as rating items, which typically comprise an MMI evaluation…

CANDLES AND INCENSE AS POTENTIAL SOURCES OF INDOOR AIR POLLUTION: MARKET ANALYSIS AND LITERATURE SEARCH

EPA Science Inventory

The report summarizes available information on candles and incense as potential sources of indoor air pollution. It covers market information and a review of the scientific literature. The market information collected focuses on production and sales data, typical uses in the U.S....

Transuranic sealed source recovery project.

PubMed

Tompkins, J A; Pearson, M W

2001-11-01

If you have transuranic sealed sources (239Pu, 238Pu, or 241Am) that have no potential for recycle or commercial disposal, the Off Site Source Recovery Project at LANL can assist in recovering the sealed sources from your facility to a DOE storage site.

Exploring the Effect of Media, Salinity and Clay on the Thermoelectric Coupling Coefficient in Self-Potential Data

NASA Astrophysics Data System (ADS)

Meyer, C. D.; Revil, A.

2014-12-01

Self-potential is a non-invasive, passive geophysical technique with applications ranging from imaging oil and gas reservoirs to identifying preferential flow paths in earthen embankments. Several cross-coupled flow phenomena contribute to self-potential data, and there is a need to further quantify these various sources to enable better resolution and quantification of self-potential models. Very little research has been done to constrain thermoelectric source mechanisms that contribute to self-potential signals. A laboratory experiment has been designed to investigate the thermoelectric coupling coefficient (CTE) that relates the voltage change per degree centigrade (V/°C) in porous media. This study focuses on a sand tank experiment using a saturated silica sand. To isolate the temperature gradient dependence of self-potential measurements, no hydraulic gradient is applied to the tank, eliminating the streaming potential component of source current. Self-potential and temperature data are recorded while reservoirs of hot and cold water are established on opposite ends of the tank in order to generate thermoelectric source currents. Various thermal gradients ranging from 0 °C to 80 °C over 20 cm are examined for various salinities (10-3M- 1M NaCl), sand grain sizes and clay content to investigate influences on CTE. A short-duration contact of non-polarizing (Pb/PbCl) electrodes is implemented to minimize temperature drift of electrodes during the experiment. Surface self-potential and temperature measurements are made in 30 minute intervals. Initial measurements have revealed non-linear effects, including a decreased CTE as temperature gradient bounds approach 0 °C.

Interpreting stream sediment fingerprints against primary and secondary source signatures in agricultural catchments

NASA Astrophysics Data System (ADS)

Blake, Will H.; Haley, Steve; Smith, Hugh G.; Taylor, Alex; Goddard, Rupert; Lewin, Sean; Fraser, David

2013-04-01

Many sediment fingerprinting studies adopt a black box approach to source apportionment whereby the properties of downstream sediment are compared quantitatively to the geochemical fingerprints of potential catchment sources without consideration of potential signature development or modification during transit. Working within a source-pathway-receptor framework, this study aimed to undertake sediment source apportionment within 6 subcatchments of an agricultural river basin with specific attention to the potential role of contaminants (vehicle emissions and mine waste) in development of stream sediment signatures. Fallout radionuclide (FRN) and geochemical fingerprinting methods were adopted independently to establish source signatures for primary sediment sources of surface and subsurface soil materials under various land uses plus reworked mine and 'secondary' soil material deposited, in transit, along road networks. FRN data demonstrated expected variability between surface soil (137Cs = 14 ± 3 Bq kg-1; 210Pbxs = 40 ± 7 Bq kg-1) and channel bank materials (137Cs = 3 ± 1 Bq kg-1; 210Pbxs = 24 ± 5 Bq kg-1) but road transported soil material was considerably elevated in 210Pbxs (up to 673 ± 51 Bq kg-1) due to sediment interaction with pluvial surface water within the road network. Geochemical discrimination between surface and subsurface soil materials was dominated by alkaline earth and alkali metals e.g. Ba, Rb, Ca, K, Mg which are sensitive to weathering processes in soil. Magnetic susceptibility and heavy metals were important discriminators of road transported material which demonstrated transformation of the signatures of material transported via the road network. Numerical unmixing of stream sediment indicated that alongside channel bank erosion, road transported material was an important component in some systems in accord with FRN evidence. While mining spoil also ranked as a significant source in an affected catchment, perhaps related to legacy sediment, the potential role of dissolved metal leaching and subsequent sediment-water interaction within the channel on signature modification remained unclear. Consideration of sediment signature modification en route from primary source to stream elucidated important information regarding sediment transfer pathways and dynamics relevant to sediment management decisions. Further work on sediment-water interactions and potential for signature transformation in the channel environment is required.

75 FR 26102 - Approval and Promulgation of Implementation Plans, State of California, San Joaquin Valley...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-11

... provide for review of new and modified stationary sources (``new source review'' or NSR) within the... the requirements and exemptions for review of new or modified stationary sources (``new source review... Modified Stationary 12/18/08 03/17/09 Source Review Rule. SJVUAPCD 2530 Federally Enforceable Potential 12...

Modeling deep brain stimulation: point source approximation versus realistic representation of the electrode

NASA Astrophysics Data System (ADS)

Zhang, Tianhe C.; Grill, Warren M.

2010-12-01

Deep brain stimulation (DBS) has emerged as an effective treatment for movement disorders; however, the fundamental mechanisms by which DBS works are not well understood. Computational models of DBS can provide insights into these fundamental mechanisms and typically require two steps: calculation of the electrical potentials generated by DBS and, subsequently, determination of the effects of the extracellular potentials on neurons. The objective of this study was to assess the validity of using a point source electrode to approximate the DBS electrode when calculating the thresholds and spatial distribution of activation of a surrounding population of model neurons in response to monopolar DBS. Extracellular potentials in a homogenous isotropic volume conductor were calculated using either a point current source or a geometrically accurate finite element model of the Medtronic DBS 3389 lead. These extracellular potentials were coupled to populations of model axons, and thresholds and spatial distributions were determined for different electrode geometries and axon orientations. Median threshold differences between DBS and point source electrodes for individual axons varied between -20.5% and 9.5% across all orientations, monopolar polarities and electrode geometries utilizing the DBS 3389 electrode. Differences in the percentage of axons activated at a given amplitude by the point source electrode and the DBS electrode were between -9.0% and 12.6% across all monopolar configurations tested. The differences in activation between the DBS and point source electrodes occurred primarily in regions close to conductor-insulator interfaces and around the insulating tip of the DBS electrode. The robustness of the point source approximation in modeling several special cases—tissue anisotropy, a long active electrode and bipolar stimulation—was also examined. Under the conditions considered, the point source was shown to be a valid approximation for predicting excitation of populations of neurons in response to DBS.

Gauging Through the Crowd: A Crowd-Sourcing Approach to Urban Rainfall Measurement and Storm Water Modeling Implications

NASA Astrophysics Data System (ADS)

Yang, Pan; Ng, Tze Ling

2017-11-01

Accurate rainfall measurement at high spatial and temporal resolutions is critical for the modeling and management of urban storm water. In this study, we conduct computer simulation experiments to test the potential of a crowd-sourcing approach, where smartphones, surveillance cameras, and other devices act as precipitation sensors, as an alternative to the traditional approach of using rain gauges to monitor urban rainfall. The crowd-sourcing approach is promising as it has the potential to provide high-density measurements, albeit with relatively large individual errors. We explore the potential of this approach for urban rainfall monitoring and the subsequent implications for storm water modeling through a series of simulation experiments involving synthetically generated crowd-sourced rainfall data and a storm water model. The results show that even under conservative assumptions, crowd-sourced rainfall data lead to more accurate modeling of storm water flows as compared to rain gauge data. We observe the relative superiority of the crowd-sourcing approach to vary depending on crowd participation rate, measurement accuracy, drainage area, choice of performance statistic, and crowd-sourced observation type. A possible reason for our findings is the differences between the error structures of crowd-sourced and rain gauge rainfall fields resulting from the differences between the errors and densities of the raw measurement data underlying the two field types.

Atomic processes and equation of state of high Z plasmas for EUV sources and their effects on the spatial and temporal evolution of the plasmas

NASA Astrophysics Data System (ADS)

Sasaki, Akira; Sunahara, Atushi; Furukawa, Hiroyuki; Nishihara, Katsunobu; Nishikawa, Takeshi; Koike, Fumihiro

2016-03-01

Laser-produced plasma (LPP) extreme ultraviolet (EUV) light sources have been intensively investigated due to potential application to next-generation semiconductor technology. Current studies focus on the atomic processes and hydrodynamics of plasmas to develop shorter wavelength sources at λ = 6.x nm as well as to improve the conversion efficiency (CE) of λ = 13.5 nm sources. This paper examines the atomic processes of mid-z elements, which are potential candidates for λ = 6.x nm source using n=3-3 transitions. Furthermore, a method to calculate the hydrodynamics of the plasmas in terms of the initial interaction between a relatively weak prepulse laser is presented.

Event-related potential evidence of accessing gender stereotypes to aid source monitoring.

PubMed

Leynes, P Andrew; Crawford, Jarret T; Radebaugh, Anne M; Taranto, Elizabeth

2013-01-23

Source memory for the speaker's voice (male or female) was investigated when semantic knowledge (gender stereotypes) could and could not inform the episodic source judgment while event-related potentials (ERPs) were recorded. Source accuracy was greater and response times were faster when stereotypes could predict the speaker's voice at test. Recollection supported source judgments in both conditions as indicated by significant parietal "old/new" ERP effects (500-800ms). Prototypical late ERP effects (the right frontal "old/new" effect and the late posterior negativity, LPN) were evident when source judgment was based solely on episodic memory. However, these two late ERP effects were diminished and a novel, frontal-negative ERP with left-central topography was observed when stereotypes aided source judgments. This pattern of ERP activity likely reflects activation of left frontal or left temporal lobes when semantic knowledge, in the form of a gender stereotype, is accessed to inform the episodic source judgment. Copyright © 2012 Elsevier B.V. All rights reserved.

Source water assessment and nonpoint sources of acutely toxic contaminants: A review of research related to survival and transport of Cryptosporidium parvum

NASA Astrophysics Data System (ADS)

Walker, Mark J.; Montemagno, Carlo D.; Jenkins, Michael B.

1998-12-01

Amendments to the Safe Drinking Water Act (PL-930123) in 1996 required that public water supply managers identify potential sources of contamination within contributing areas. Nonpoint sources of acutely toxic microbial contaminants, such as Cryptosporidium parvum, challenge current approaches to source identification and management as a first step toward developing management plans for public water supply protection. Little may be known about survival and transport in the field environment, prescribed practices may not be designed to manage such substances, and infective stages may be present in vast numbers and may resist water treatment and disinfection processes. This review summarizes research related to survival and transport of C. parvum oocysts, as an example of an acutely toxic contaminant with nonpoint sources in animal agriculture. It discusses ∥1) significance of infected domesticated animals as potential sources of C. parvum, (2) laboratory and field studies of survival and transport, and (3) approaches to source control in the context of public health protection.

Identifying sources of nitrogen to Hanalei Bay, Kauai, utilizing the nitrogen isotope signature of macroalgae

USGS Publications Warehouse

Derse, E.; Knee, K.L.; Wankel, Scott D.; Kendall, C.; Berg, C.J.; Paytan, A.

2007-01-01

Sewage effluent, storm runoff, discharge from polluted rivers, and inputs of groundwater have all been suggested as potential sources of land derived nutrients into Hanalei Bay, Kauai. We determined the nitrogen isotopic signatures (??15N) of different nitrate sources to Hanalei Bay along with the isotopic signature recorded by 11 species of macroalgal collected in the Bay. The macroalgae integrate the isotopic signatures of the nitrate sources over time, thus these data along with the nitrate to dissolved inorganic phosphate molar ratios (N:P) of the macroalgae were used to determine the major nitrate source to the bay ecosystem and which of the macro-nutrients is limiting algae growth, respectively. Relatively low ??15N values (average -0.5???) were observed in all algae collected throughout the Bay; implicating fertilizer, rather than domestic sewage, as an important external source of nitrogen to the coastal water around Hanalei. The N:P ratio in the algae compared to the ratio in the Bay waters imply that the Hanalei Bay coastal ecosystem is nitrogen limited and thus, increased nitrogen input may potentially impactthis coastal ecosystem and specifically the coral reefs in the Bay. Identifying the major source of nutrient loading to the Bay is important for risk assessment and potential remediation plans. ?? 2007 American Chemical Society.

Tapping the grapevine: a closer look at word-of-mouth as a recruitment source.

PubMed

Van Hoye, Greet; Lievens, Filip

2009-03-01

To advance knowledge of word-of-mouth as a company-independent recruitment source, this study draws on conceptualizations of word-of-mouth in the marketing literature. The sample consisted of 612 potential applicants targeted by the Belgian Defense. Consistent with the recipient-source framework, time spent receiving positive word-of-mouth was determined by the traits of the recipient (extraversion and conscientiousness), the characteristics of the source (perceived expertise), and their mutual relationship (tie strength). Only conscientiousness and source expertise were determinants of receiving negative word-of-mouth. In line with the accessibility-diagnosticity model, receiving positive employment information through word-of-mouth early in the recruitment process was positively associated with perceptual (organizational attractiveness) and behavioral outcomes (actual application decisions), beyond potential applicants' exposure to other recruitment sources. (c) 2009 APA, all rights reserved.

Exploring the Hard and Soft X-ray Emission of Magnetic Cataclysmic Variables

NASA Astrophysics Data System (ADS)

de Martino, D.; Anzolin, G.; Bonnet-Bidaud, J.-M.; Falanga, M.; Matt, G.; Mouchet, M.; Mukai, K.; Masetti, N.

2009-05-01

A non-negligible fraction of galactic hard (>20 keV) X-ray sources were identified as CVs of the magnetic Intermediate Polar type in INTEGRAL, SWIFT and RXTE surveys, that suggests a still hidden but potentially important population of faint hard X-ray sources. Simbol-X has the unique potential to simultaneously characterize their variable and complex soft and hard X-ray emission thus allowing to understand their putative role in galactic populations of X-ray sources.

Local Field Potentials: Myths and Misunderstandings

PubMed Central

Herreras, Oscar

2016-01-01

The intracerebral local field potential (LFP) is a measure of brain activity that reflects the highly dynamic flow of information across neural networks. This is a composite signal that receives contributions from multiple neural sources, yet interpreting its nature and significance may be hindered by several confounding factors and technical limitations. By and large, the main factor defining the amplitude of LFPs is the geometry of the current sources, over and above the degree of synchronization or the properties of the media. As such, similar levels of activity may result in potentials that differ in several orders of magnitude in different populations. The geometry of these sources has been experimentally inaccessible until intracerebral high density recordings enabled the co-activating sources to be revealed. Without this information, it has proven difficult to interpret a century's worth of recordings that used temporal cues alone, such as event or spike related potentials and frequency bands. Meanwhile, a collection of biophysically ill-founded concepts have been considered legitimate, which can now be corrected in the light of recent advances. The relationship of LFPs to their sources is often counterintuitive. For instance, most LFP activity is not local but remote, it may be larger further from rather than close to the source, the polarity does not define its excitatory or inhibitory nature, and the amplitude may increase when source's activity is reduced. As technological developments foster the use of LFPs, the time is now ripe to raise awareness of the need to take into account spatial aspects of these signals and of the errors derived from neglecting to do so. PMID:28018180

Spherical earth gravity and magnetic anomaly analysis by equivalent point source inversion

NASA Technical Reports Server (NTRS)

Von Frese, R. R. B.; Hinze, W. J.; Braile, L. W.

1981-01-01

To facilitate geologic interpretation of satellite elevation potential field data, analysis techniques are developed and verified in the spherical domain that are commensurate with conventional flat earth methods of potential field interpretation. A powerful approach to the spherical earth problem relates potential field anomalies to a distribution of equivalent point sources by least squares matrix inversion. Linear transformations of the equivalent source field lead to corresponding geoidal anomalies, pseudo-anomalies, vector anomaly components, spatial derivatives, continuations, and differential magnetic pole reductions. A number of examples using 1 deg-averaged surface free-air gravity anomalies of POGO satellite magnetometer data for the United States, Mexico, and Central America illustrate the capabilities of the method.

Investigation of the potential for long-range transport of mercury to the Everglades using the organic chemistry integrated dispersion (ORCHID) model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burns, D.S.; Kienzle, M.A.; Ferris, D.C.

1996-12-31

The objective of this study is to identify potential long-range sources of mercury within the southeast region of the United States. Preliminary results of a climatological study using the Short-range Layered Atmospheric Model (SLAM) transport model from a select source in the southeast U.S. are presented. The potential for long-range transport from Oak Ridge, Tennessee to Florida is discussed. The transport and transformation of mercury during periods of favorable transport to south Florida is modeled using the Organic Chemistry Integrated Dispersion (ORCHID) model, which contains the transport model used in the climatology study. SLAM/ORCHID results indicate the potential for mercurymore » reaching southeast Florida from the source and the atmospheric oxidation of mercury during transport.« less

How to know and choose online games: differences between current and potential players.

PubMed

Teng, Ching-I; Lo, Shao-Kang; Wang, Pe-Cheng

2007-12-01

This study investigated how different adolescent players acquire game information and the criteria they use in choosing online games and found that (1) current players generally use comprehensive information sources more than potential players do; (2) current players rely on free trials and smooth display of motion graphics as choice criteria more than potential players do; (3) potential players rely on the look of advertisements more than current players do; (4) both current and potential players most likely use word-of-mouth and gaming programs on TV as information sources; and (5) endorser attractiveness is ranked the least important among six choice criteria by both current and potential players.

Recent advances in laser-driven neutron sources

NASA Astrophysics Data System (ADS)

Alejo, A.; Ahmed, H.; Green, A.; Mirfayzi, S. R.; Borghesi, M.; Kar, S.

2016-11-01

Due to the limited number and high cost of large-scale neutron facilities, there has been a growing interest in compact accelerator-driven sources. In this context, several potential schemes of laser-driven neutron sources are being intensively studied employing laser-accelerated electron and ion beams. In addition to the potential of delivering neutron beams with high brilliance, directionality and ultra-short burst duration, a laser-driven neutron source would offer further advantages in terms of cost-effectiveness, compactness and radiation confinement by closed-coupled experiments. Some of the recent advances in this field are discussed, showing improvements in the directionality and flux of the laser-driven neutron beams.

Light sources based on semiconductor current filaments

DOEpatents

Zutavern, Fred J.; Loubriel, Guillermo M.; Buttram, Malcolm T.; Mar, Alan; Helgeson, Wesley D.; O'Malley, Martin W.; Hjalmarson, Harold P.; Baca, Albert G.; Chow, Weng W.; Vawter, G. Allen

2003-01-01

The present invention provides a new type of semiconductor light source that can produce a high peak power output and is not injection, e-beam, or optically pumped. The present invention is capable of producing high quality coherent or incoherent optical emission. The present invention is based on current filaments, unlike conventional semiconductor lasers that are based on p-n junctions. The present invention provides a light source formed by an electron-hole plasma inside a current filament. The electron-hole plasma can be several hundred microns in diameter and several centimeters long. A current filament can be initiated optically or with an e-beam, but can be pumped electrically across a large insulating region. A current filament can be produced in high gain photoconductive semiconductor switches. The light source provided by the present invention has a potentially large volume and therefore a potentially large energy per pulse or peak power available from a single (coherent) semiconductor laser. Like other semiconductor lasers, these light sources will emit radiation at the wavelength near the bandgap energy (for GaAs 875 nm or near infra red). Immediate potential applications of the present invention include high energy, short pulse, compact, low cost lasers and other incoherent light sources.

CO2 mitigation potential of mineral carbonation with industrial alkalinity sources in the United States.

PubMed

Kirchofer, Abby; Becker, Austin; Brandt, Adam; Wilcox, Jennifer

2013-07-02

The availability of industrial alkalinity sources is investigated to determine their potential for the simultaneous capture and sequestration of CO2 from point-source emissions in the United States. Industrial alkalinity sources investigated include fly ash, cement kiln dust, and iron and steel slag. Their feasibility for mineral carbonation is determined by their relative abundance for CO2 reactivity and their proximity to point-source CO2 emissions. In addition, the available aggregate markets are investigated as possible sinks for mineral carbonation products. We show that in the U.S., industrial alkaline byproducts have the potential to mitigate approximately 7.6 Mt CO2/yr, of which 7.0 Mt CO2/yr are CO2 captured through mineral carbonation and 0.6 Mt CO2/yr are CO2 emissions avoided through reuse as synthetic aggregate (replacing sand and gravel). The emission reductions represent a small share (i.e., 0.1%) of total U.S. CO2 emissions; however, industrial byproducts may represent comparatively low-cost methods for the advancement of mineral carbonation technologies, which may be extended to more abundant yet expensive natural alkalinity sources.

Wet deposition of mercury at a New York state rural site: Concentrations, fluxes, and source areas

NASA Astrophysics Data System (ADS)

Lai, Soon-onn; Holsen, Thomas M.; Hopke, Philip K.; Liu, Peng

Event-based mercury (Hg) precipitation samples were collected with a modified MIC-B sampler between September 2003 and April 2005 at Potsdam, NY to investigate Hg in wet deposition and identify potential source areas using the potential source contribution function (PCSF) and residence time weighted concentration (RTWC) models. The volume-weighted mean (VWM) concentration and wet deposition flux were 5.5ngL-1 and 7.6μgm-2 during the study period, and 5.5ngL-1 and 5.9μgm-2 in 2004, respectively, and show seasonal trends with larger values in the spring and summer. The PSCF model results matched known source areas based on an emission inventory better than did the RTWC results based on the spatial correlation index. Both modeling results identified large Hg source areas that contain a number of coal-fired power plants located in the Upper Ohio River Valley and in southeastern Michigan, as well as in Quebec and Ontario where there are metal production facilities, waste incinerators and paper mills. Emissions from the Atlantic Ocean were also determined to be a potential source.

Investigating the sources of sediment in a Canadian agricultural watershed using a colour-based fingerprinting technique

NASA Astrophysics Data System (ADS)

Barthod, Louise; Lobb, David; Owens, Philip; Martinez-Carreras, Nuria; Koiter, Alexander; Petticrew, Ellen; McCullough, Gregory

2014-05-01

The development of beneficial management practises to minimize adverse impacts of agriculture on soil and water quality requires information on the sources of sediment at the watershed scale. Sediment fingerprinting allows for the determination of sediment sources and apportionment of their contribution within a watershed, using unique physical, radiochemical or biogeochemical properties, or fingerprints, of the potential sediment sources. The use of sediment colour as a fingerprint is an emerging technique that can provide a rapid and inexpensive means of investigating sediment sources. This technique is currently being utilized to determine sediment sources within the South Tobacco Creek Watershed, an agricultural watershed located in the Canadian prairies (south-central Manitoba). Suspended sediment and potential source (topsoil, channel bank and shale bedrock material) samples were collected between 2009 and 2011 at six locations along the main stem of the creek. Sample colour was quantified from diffuse reflectance spectrometry measurements over the visible wavelength range using a spectroradiometer (ASD Field Spec Pro, 400-2500 nm). Sixteen colour coefficients were derived from several colour space models (CIE XYZ, CIE xyY, CIE Lab, CIE Luv, CIE Lch, Landsat RGB, Redness Index). The individual discrimination power of the colour coefficients, after passing several prerequisite tests (e.g., linearly additive behaviour), was assessed using discriminant function analysis. A stepwise discriminant analysis, based on the Wilk's lambda criterion, was then performed in order to determine the best-suited colour coefficient fingerprints which maximized the discrimination between the potential sources. The selected fingerprints classified the source samples in the correct category 86% of the time. The misclassification is due to intra-source variability and source overlap which can lead to higher uncertainty in sediment source apportionment. The selected fingerprints were then included in a Bayesian mixing model using Monte-Carlo simulation (Stable Isotope Analysis in R, SIAR) in order to apportion the contribution of the different sources to the sediment collected at each location. A switch in the dominant sediment source between the headwaters and the outlet of the watershed is observed. Sediment is enriched with shale bedrock and depleted of topsoil sources as the stream crosses and down-cuts through the Manitoba Escarpment. The switch in sources highlights the importance of the sampling location in relation to the scale and geomorphic connectivity of the watershed. Although the results include considerable uncertainty, they are consistent with the findings from a classical fingerprinting approach undertaken in the same watershed (i.e., geochemical and radionuclide fingerprints), and confirm the potential of sediment colour parameters as suitable fingerprints.

Utilization of leaf litter as a potential feed source

USDA-ARS?s Scientific Manuscript database

Proximate analysis and In-situ nylon bag ruminal dry matter degradation of fall dropped Liriodendron tulipifera (tulip poplar) and Quercus alba (white oak) leaves were used to determine their potential use as a feed source for ruminant livestock animals. Ash content was 8.24 and 4.69 ...

Introducing "Emotioncy" as a Potential Source of Test Bias: A Mixed Rasch Modeling Study

ERIC Educational Resources Information Center

Pishghadam, Reza; Baghaei, Purya; Seyednozadi, Zahra

2017-01-01

This article attempts to present emotioncy as a potential source of test bias to inform the analysis of test item performance. Emotioncy is defined as a hierarchy, ranging from "exvolvement" (auditory, visual, and kinesthetic) to "involvement" (inner and arch), to emphasize the emotions evoked by the senses. This study…

GROUNDWATER QUALITY MONITORING OF WESTERN OIL SHALE DEVELOPMENT: IDENTIFICATION AND PRIORITY RANKING OF POTENTIAL POLLUTION SOURCES

EPA Science Inventory

This report presents the development of a preliminary priority ranking of potential pollution sources with respect to groundwater quality and the associated pollutants for oil shale operations such as proposed for Federal Prototype Leases U-a and U-b in Eastern Utah. The methodol...

Effective Marketing Strategies Flow from Sound Segmentation Data.

ERIC Educational Resources Information Center

Chen, Henry C. K.; And Others

The paper investigates the potential market segments of an upper division university in transition to 4-year status, and explores selection criteria and the influence of various information sources on the choice of university by the potential target students. Data sources for the study included a survey of 142 freshmen students of whom 120…

[Seasonal Variation Characteristics and Potential Source Contribution of Sulfate, Nitrate and Ammonium in Beijing by Using Single Particle Aerosol Mass Spectrometry].

PubMed

Liu, Lang; Zhang, Wen-jie; Du, Shi-yong; Hou, Lu-jian; Han, Bin; Yang, Wen; Chen, Min-dong; Bai, Zhi-peng

2016-05-15

Single particle aerosol mass spectrometry (SPAMS) was deployed to continuously observe the aerosol particles of Beijing urban area from 2013-12 to 2014-11, and the hourly average data of sulfate, nitrate and ammonium (SNA) were obtained using the characteristic ion tracer method. The mixing state and size distribution of SNA were analyzed. In addition, based on Hysplit 48 h back air mass trajectory results in combination with Concentration Weighted Trajectory method (CWT), we obtained the seasonal potential source contribution area of SNA. The results showed that the mixture of sulfate, nitrate and ammonium in spring and summer was more stable than that in autumn and winter. The size distribution of sulfate and nitrate was very similar. The size distribution characteristics of SNA followed the order of autumn > summer > spring > winter. The potential source region of SNA had similar spatial distribution characteristics, and the potential source region of SNA was mainly located in Beijing and south areas, especially at Tianjin, Langfang, Hengshui, Baoding and Shijiazhuang.

Rock-Eval pyrolysis and vitrinite reflectance results from the Sheep Creek 1 well, Susitna basin, south-central Alaska

USGS Publications Warehouse

Stanley, Richard G.; Lillis, Paul G.; Pawlewicz, Mark J.; Haeussler, Peter J.

2014-01-01

We used Rock-Eval pyrolysis and vitrinite reflectance to examine the petroleum source potential of rock samples from the Sheep Creek 1 well in the Susitna basin of south-central Alaska. The results show that Miocene nonmarine coal, carbonaceous shale, and mudstone are potential sources of hydrocarbons and are thermally immature with respect to the oil window. In the samples that we studied, coals are more organic-rich and more oil-prone than carbonaceous shales and silty mudstones, which appear to be potential sources of natural gas. Lithologically similar rocks may be present in the deeper parts of the subsurface Susitna basin located west of the Sheep Creek 1 well, where they may have been buried deeply enough to generate oil and (or) gas. The Susitna basin is sparsely drilled and mostly unexplored, and no commercial production of hydrocarbons has been obtained. However, the existence of potential source rocks of oil and gas, as shown by our Rock-Eval results, suggests that undiscovered petroleum accumulations may be present in the Susitna basin.

Multisensory connections of monkey auditory cerebral cortex

PubMed Central

Smiley, John F.; Falchier, Arnaud

2009-01-01

Functional studies have demonstrated multisensory responses in auditory cortex, even in the primary and early auditory association areas. The features of somatosensory and visual responses in auditory cortex suggest that they are involved in multiple processes including spatial, temporal and object-related perception. Tract tracing studies in monkeys have demonstrated several potential sources of somatosensory and visual inputs to auditory cortex. These include potential somatosensory inputs from the retroinsular (RI) and granular insula (Ig) cortical areas, and from the thalamic posterior (PO) nucleus. Potential sources of visual responses include peripheral field representations of areas V2 and prostriata, as well as the superior temporal polysensory area (STP) in the superior temporal sulcus, and the magnocellular medial geniculate thalamic nucleus (MGm). Besides these sources, there are several other thalamic, limbic and cortical association structures that have multisensory responses and may contribute cross-modal inputs to auditory cortex. These connections demonstrated by tract tracing provide a list of potential inputs, but in most cases their significance has not been confirmed by functional experiments. It is possible that the somatosensory and visual modulation of auditory cortex are each mediated by multiple extrinsic sources. PMID:19619628

Palaeoenvironment and Its Control on the Formation of Miocene Marine Source Rocks in the Qiongdongnan Basin, Northern South China Sea

PubMed Central

Li, Wenhao; Zhang, Zhihuan; Wang, Weiming; Lu, Shuangfang; Li, Youchuan; Fu, Ning

2014-01-01

The main factors of the developmental environment of marine source rocks in continental margin basins have their specificality. This realization, in return, has led to the recognition that the developmental environment and pattern of marine source rocks, especially for the source rocks in continental margin basins, are still controversial or poorly understood. Through the analysis of the trace elements and maceral data, the developmental environment of Miocene marine source rocks in the Qiongdongnan Basin is reconstructed, and the developmental patterns of the Miocene marine source rocks are established. This paper attempts to reveal the hydrocarbon potential of the Miocene marine source rocks in different environment and speculate the quality of source rocks in bathyal region of the continental slope without exploratory well. Our results highlight the palaeoenvironment and its control on the formation of Miocene marine source rocks in the Qiongdongnan Basin of the northern South China Sea and speculate the hydrocarbon potential of the source rocks in the bathyal region. This study provides a window for better understanding the main factors influencing the marine source rocks in the continental margin basins, including productivity, preservation conditions, and the input of terrestrial organic matter. PMID:25401132

Leptospirosis risk around a potential source of infection

NASA Astrophysics Data System (ADS)

Loaiza-Echeverry, Erica; Hincapié-Palacio, Doracelly; Ochoa Acosta, Jesús; Ospina Giraldo, Juan

2015-05-01

Leptospirosis is a bacterial zoonosis with world distribution and multiform clinical spectrum in men and animals. The etiology of this disease is the pathogenic species of Leptospira, which cause diverse manifestations of the disease, from mild to serious, such as the Weil disease and the lung hemorrhagic syndrome with lethal proportions of 10% - 50%. This is an emerging problem of urban health due to the growth of marginal neighborhoods without basic sanitary conditions and an increased number of rodents. The presence of rodents and the probability of having contact with their urine determine the likelihood for humans to get infected. In this paper, we simulate the spatial distribution of risk infection of human leptospirosis according to the proximity to rodent burrows considered as potential source of infection. The Bessel function K0 with an r distance from the potential point source, and the scale parameter α in meters was used. Simulation inputs were published data of leptospirosis incidence rate (range of 5 to 79 x 10 000), and a distance of 100 to 5000 meters from the source of infection. We obtained an adequate adjustment between the function and the simulated data. The risk of infection increases with the proximity of the potential source. This estimation can become a guide to propose effective measures of control and prevention.

A review on potential use of low-temperature water in the urban environment as a thermal-energy source

NASA Astrophysics Data System (ADS)

Laanearu, J.; Borodinecs, A.; Rimeika, M.; Palm, B.

2017-10-01

The thermal-energy potential of urban water sources is largely unused to accomplish the up-to-date requirements of the buildings energy demands in the cities of Baltic Sea Region. A reason is that the natural and excess-heat water sources have a low temperature and heat that should be upgraded before usage. The demand for space cooling should increase in near future with thermal insulation of buildings. There are a number of options to recover heat also from wastewater. It is proposed that a network of heat extraction and insertion including the thermal-energy recovery schemes has potential to be broadly implemented in the region with seasonally alternating temperature. The mapping of local conditions is essential in finding the suitable regions (hot spots) for future application of a heat recovery schemes by combining information about demands with information about available sources. The low-temperature water in the urban environment is viewed as a potential thermal-energy source. To recover thermal energy efficiently, it is also essential to ensure that it is used locally, and adverse effects on environment and industrial processes are avoided. Some characteristics reflecting the energy usage are discussed in respect of possible improvements of energy efficiency.

Rabbit Feces as Feed for Ruminants and as an Energy Source.

PubMed

Peiretti, Pier Giorgio; Tassone, Sonia; Gai, Francesco; Gasco, Laura; Masoero, Giorgio

2014-12-05

There are prospects for using novel feeds from various sources to provide ruminants with alternative sources of protein and energy such as by-products, and animal wastes. Rabbit feces are a concentrated source of fiber and could have commercial potential both as input biomass in anaerobic processes for biogas production, as well as a fibrous source for ruminal degradation. The aims of this work were to assess the potential as ruminant feeding and as biogas production of rabbit feces, in comparison with 12 crops. The chemical composition and the potential and experimental in vitro true digestibility (IVTD) and neutral detergent fiber digestibility (NDFD) of 148 feces samples were determined by using chemical methods, Daisy system digestibility and/or NIRS predictions. The average biomethane potential (BMP) was 286 ± 10 lCH4/kg SV with -4% vs. the crops average. Milk forage unit (milk FU), IVTD and NDFD of feces were 0.54 ± 0.06 milk FU/kg DM, 74% ± 3% and 50% ± 5%, respectively, with comparisons of -19%, -11% and -24% vs. the crops average. Reconstruction of the potential values based on the chemical constituents but using the crop partial least square model well agreed with the NIRS calibrations and cross-validation. In a global NIRS calibration of the feces and crops the relative predicted deviation for IVTD, NDFD and milk FU were 3.1, 2.9 and 2.6, respectively, and only 1.5 for BMP. Running the Daisy system for rabbit feces in rumen fluid gave some inconsistencies, weakened the functional relationships, and appeared not to be correlated with the potential values of IVTD and NDFD. Nevertheless, the energetic potential of feces appears to be similar to some conventional crops at different degrees of maturity. Thus we conclude that rabbit feces has potential value as a ruminant feed and for biogas production.

MHODE: a local-homogeneity theory for improved source-parameter estimation of potential fields

NASA Astrophysics Data System (ADS)

Fedi, Maurizio; Florio, Giovanni; Paoletti, Valeria

2015-08-01

We describe a multihomogeneity theory for source-parameter estimation of potential fields. Similar to what happens for random source models, where the monofractal scaling-law has been generalized into a multifractal law, we propose to generalize the homogeneity law into a multihomogeneity law. This allows a theoretically correct approach to study real-world potential fields, which are inhomogeneous and so do not show scale invariance, except in the asymptotic regions (very near to or very far from their sources). Since the scaling properties of inhomogeneous fields change with the scale of observation, we show that they may be better studied at a set of scales than at a single scale and that a multihomogeneous model is needed to explain its complex scaling behaviour. In order to perform this task, we first introduce fractional-degree homogeneous fields, to show that: (i) homogeneous potential fields may have fractional or integer degree; (ii) the source-distributions for a fractional-degree are not confined in a bounded region, similarly to some integer-degree models, such as the infinite line mass and (iii) differently from the integer-degree case, the fractional-degree source distributions are no longer uniform density functions. Using this enlarged set of homogeneous fields, real-world anomaly fields are studied at different scales, by a simple search, at any local window W, for the best homogeneous field of either integer or fractional-degree, this yielding a multiscale set of local homogeneity-degrees and depth estimations which we call multihomogeneous model. It is so defined a new technique of source parameter estimation (Multi-HOmogeneity Depth Estimation, MHODE), permitting retrieval of the source parameters of complex sources. We test the method with inhomogeneous fields of finite sources, such as faults or cylinders, and show its effectiveness also in a real-case example. These applications show the usefulness of the new concepts, multihomogeneity and fractional homogeneity-degree, to obtain valid estimates of the source parameters in a consistent theoretical framework, so overcoming the limitations imposed by global-homogeneity to widespread methods, such as Euler deconvolution.

Oxidative potential and inflammatory impacts of source apportioned ambient air pollution in Beijing.

PubMed

Liu, Qingyang; Baumgartner, Jill; Zhang, Yuanxun; Liu, Yanju; Sun, Yongjun; Zhang, Meigen

2014-11-04

Air pollution exposure is associated with a range of adverse health impacts. Knowledge of the chemical components and sources of air pollution most responsible for these health effects could lead to an improved understanding of the mechanisms of such effects and more targeted risk reduction strategies. We measured daily ambient fine particulate matter (<2.5 μm in aerodynamic diameter; PM2.5) for 2 months in peri-urban and central Beijing, and assessed the contribution of its chemical components to the oxidative potential of ambient air pollution using the dithiothreitol (DTT) assay. The composition data were applied to a multivariate source apportionment model to determine the PM contributions of six sources or factors: a zinc factor, an aluminum factor, a lead point factor, a secondary source (e.g., SO4(2-), NO3(2-)), an iron source, and a soil dust source. Finally, we assessed the relationship between reactive oxygen species (ROS) activity-related PM sources and inflammatory responses in human bronchial epithelial cells. In peri-urban Beijing, the soil dust source accounted for the largest fraction (47%) of measured ROS variability. In central Beijing, a secondary source explained the greatest fraction (29%) of measured ROS variability. The ROS activities of PM collected in central Beijing were exponentially associated with in vivo inflammatory responses in epithelial cells (R2=0.65-0.89). We also observed a high correlation between three ROS-related PM sources (a lead point factor, a zinc factor, and a secondary source) and expression of an inflammatory marker (r=0.45-0.80). Our results suggest large differences in the contribution of different PM sources to ROS variability at the central versus peri-urban study sites in Beijing and that secondary sources may play an important role in PM2.5-related oxidative potential and inflammatory health impacts.

Tracking antibiotic resistance gene pollution from different sources using machine-learning classification.

PubMed

Li, Li-Guan; Yin, Xiaole; Zhang, Tong

2018-05-24

Antimicrobial resistance (AMR) has been a worldwide public health concern. Current widespread AMR pollution has posed a big challenge in accurately disentangling source-sink relationship, which has been further confounded by point and non-point sources, as well as endogenous and exogenous cross-reactivity under complicated environmental conditions. Because of insufficient capability in identifying source-sink relationship within a quantitative framework, traditional antibiotic resistance gene (ARG) signatures-based source-tracking methods would hardly be a practical solution. By combining broad-spectrum ARG profiling with machine-learning classification SourceTracker, here we present a novel way to address the question in the era of high-throughput sequencing. Its potential in extensive application was firstly validated by 656 global-scale samples covering diverse environmental types (e.g., human/animal gut, wastewater, soil, ocean) and broad geographical regions (e.g., China, USA, Europe, Peru). Its potential and limitations in source prediction as well as effect of parameter adjustment were then rigorously evaluated by artificial configurations with representative source proportions. When applying SourceTracker in region-specific analysis, excellent performance was achieved by ARG profiles in two sample types with obvious different source compositions, i.e., influent and effluent of wastewater treatment plant. Two environmental metagenomic datasets of anthropogenic interference gradient further supported its potential in practical application. To complement general-profile-based source tracking in distinguishing continuous gradient pollution, a few generalist and specialist indicator ARGs across ecotypes were identified in this study. We demonstrated for the first time that the developed source-tracking platform when coupling with proper experiment design and efficient metagenomic analysis tools will have significant implications for assessing AMR pollution. Following predicted source contribution status, risk ranking of different sources in ARG dissemination will be possible, thereby paving the way for establishing priority in mitigating ARG spread and designing effective control strategies.

Potential microbial risk factors related to soil amendments and irrigation water of potato crops.

PubMed

Selma, M V; Allende, A; López-Gálvez, F; Elizaquível, P; Aznar, R; Gil, M I

2007-12-01

This study assesses the potential microbial risk factors related to the use of soil amendments and irrigation water on potato crops, cultivated in one traditional and two intensive farms during two harvest seasons. The natural microbiota and potentially pathogenic micro-organisms were evaluated in the soil amendment, irrigation water, soil and produce. Uncomposted amendments and residual and creek water samples showed the highest microbial counts. The microbial load of potatoes harvested in spring was similar among the tested farms despite the diverse microbial levels of Listeria spp. and faecal coliforms in the potential risk sources. However, differences in total coliform load of potato were found between farms cultivated in the autumn. Immunochromatographic rapid tests and the BAM's reference method (Bacteriological Analytical Manual; AOAC International) were used to detect Escherichia coli O157:H7 from the potential risk sources and produce. Confirmation of the positive results by polymerase chain reaction procedures showed that the immunochromatographic assay was not reliable as it led to false-positive results. The potentially pathogenic micro-organisms of soil amendment, irrigation water and soil samples changed with the harvest seasons and the use of different agricultural practices. However, the microbial load of the produce was not always influenced by these risk sources. Improvements in environmental sample preparation are needed to avoid interferences in the use of immunochromatographic rapid tests. The potential microbial risk sources of fresh produce should be regularly controlled using reliable detection methods to guarantee their microbial safety.

Datasets collected in general practice: an international comparison using the example of obesity.

PubMed

Sturgiss, Elizabeth; van Boven, Kees

2018-06-04

International datasets from general practice enable the comparison of how conditions are managed within consultations in different primary healthcare settings. The Australian Bettering the Evaluation and Care of Health (BEACH) and TransHIS from the Netherlands collect in-consultation general practice data that have been used extensively to inform local policy and practice. Obesity is a global health issue with different countries applying varying approaches to management. The objective of the present paper is to compare the primary care management of obesity in Australia and the Netherlands using data collected from consultations. Despite the different prevalence in obesity in the two countries, the number of patients per 1000 patient-years seen with obesity is similar. Patients in Australia with obesity are referred to allied health practitioners more often than Dutch patients. Without quality general practice data, primary care researchers will not have data about the management of conditions within consultations. We use obesity to highlight the strengths of these general practice data sources and to compare their differences. What is known about the topic? Australia had one of the longest-running consecutive datasets about general practice activity in the world, but it has recently lost government funding. The Netherlands has a longitudinal general practice dataset of information collected within consultations since 1985. What does this paper add? We discuss the benefits of general practice-collected data in two countries. Using obesity as a case example, we compare management in general practice between Australia and the Netherlands. This type of analysis should start all international collaborations of primary care management of any health condition. Having a national general practice dataset allows international comparisons of the management of conditions with primary care. Without a current, quality general practice dataset, primary care researchers will not be able to partake in these kinds of comparison studies. What are the implications for practitioners? Australian primary care researchers and clinicians will be at a disadvantage in any international collaboration if they are unable to accurately describe current general practice management. The Netherlands has developed an impressive dataset that requires within-consultation data collection. These datasets allow for person-centred, symptom-specific, longitudinal understanding of general practice management. The possibilities for the quasi-experimental questions that can be answered with such a dataset are limitless. It is only with the ability to answer clinically driven questions that are relevant to primary care that the clinical care of patients can be measured, developed and improved.

Health economic research on vaccinations and immunisation practices--an introductory primer.

PubMed

Szucs, Thomas D

2005-03-18

The economic importance of vaccines lies partly in the burden of disease that can be avoided and partly in the competition for resources between vaccines and other interventions. Up to the 1980s only few economic evaluations had been carried out. Since then the confrontation of most countries with escalating health care costs and tighter budgets have awakened the interest in pharmacoeconomic analysis. Resources used to provide health care are vast but not limitless. When clinicians are asked to participate in decisions for large groups of patients (in a managed care context, in an institution, or at the level of local health authorities), the balance between consumption of resources and the benefits of an intervention is important. Clinicians may use cost-effectiveness and cost-benefit studies to inform such decisions (but not to make them). Because of differences in methods, the presentation of results, and country-specific parameters, economic evaluations of the same vaccination strategy by different groups may have divergent results. Vaccines differ from classical medicines in at least three ways: firstly, there is a longer tradition of economic evaluations for vaccines than for medicines. Some of the most earliest economic studies were carried out in the field of vaccines in the public health arena. Secondly, comparatively fewer central decision makers need to be convinced as compared to drugs. The reason for this being a more centralised process of recommending vaccines and vaccination policies. Thirdly, externalities are more relevant in the field of vaccines. Such externalities may be positive or negative. Positive externalities are present in the case where herd immunity prevents the spread of the disease in the community. We are now undoubtedly in an era of assessment and accountability for all new technologies in healthcare. However, sufficient economic data are still lacking to support the formulation of health policy and a particular challenge for the future is to conduct further health economic research on immunisation. Specific areas for such study include: effectiveness under field conditions (i.e., not under the conditions of a randomised controlled trial); the real value of economic production losses; the conditions for implementing novel immunization programmes; cost estimates for more ambitious immunization programmes; the economic benefits of combination vaccines. From this research, it will be important to disseminate the data and to adapt the findings to other countries. Nevertheless, the source of funding for research and its application in clinical trials programmes represent some of the practical problems faced by medical economics today within academia and the industry.

Early Warning and Outbreak Detection Using Social Networking Websites: The Potential of Twitter

NASA Astrophysics Data System (ADS)

de Quincey, Ed; Kostkova, Patty

Epidemic Intelligence is being used to gather information about potential diseases outbreaks from both formal and increasingly informal sources. A potential addition to these informal sources are social networking sites such as Facebook and Twitter. In this paper we describe a method for extracting messages, called "tweets" from the Twitter website and the results of a pilot study which collected over 135,000 tweets in a week during the current Swine Flu pandemic.

Space tourism: from earth orbit to the moon

NASA Astrophysics Data System (ADS)

Collins, P.

Travel to and from the lunar surface has been known to be feasible since it was first achieved 34 years ago. Since that time there has been enormous progress in related engineering fields such as rocket propulsion, materials and avionics, and about 1 billion has been spent on lunar science and engineering research. Consequently there are no fundamental technical problems facing the development of lunar tourism - only business and investment problems. The outstanding problem is to reduce the cost of launch to low Earth orbit. Recently there has been major progress towards overturning the myth that launch costs are high because of physical limits. Several "X Prize" competitor vehicles currently in test-flight are expected to be able to perform sub-orbital flights at approximately 1/1,000 of the cost of Alan Shepard's similar flight in 1961. This activity could have started 30 years ago if space agencies had had economic rather than political objectives. A further encouraging factor is that the demand for space tourism seems potentially limitless. Starting with sub-orbital flights and growing through orbital activities, travel to the Moon will offer further unique attractions. In every human culture there is immense interest in the Moon arising from millennia of myths. In addition, bird-like flying sports, first described by Robert Heinlein, will become another powerful demand factor. Roundtrips of 1 to 2 weeks are very convenient for travel companies; and the radiation environment will permit visitors several days of surface activity without significant health risks. The paper also discusses economic aspects of lunar tourism, including the benefits it will have for those on Earth. Lunar economic development based on tourism will have much in common with economic development on Earth based on tourism: starting from the fact that many people spontaneously wish to visit popular places, companies in the tourism industry invest to sell a growing range of services to ever more customers, thereby creating a major new hubs of economic activity and wealth. In the same way as trade with the "New World" enriched the "Old World" of Europe as well as emigrants themselves, the contribution of tourism to the economic development of the Moon will also create wealth on Earth, and open numerous opportunities for innovation.

Dipolar sources of the early scalp somatosensory evoked potentials to upper limb stimulation. Effect of increasing stimulus rates.

PubMed

Valeriani, M; Restuccia, D; Di Lazzaro, V; Le Pera, D; Barba, C; Tonali, P; Mauguiere, F

1998-06-01

Brain electrical source analysis (BESA) of the scalp electroencephalographic activity is well adapted to distinguish neighbouring cerebral generators precisely. Therefore, we performed dipolar source modelling in scalp medium nerve somatosensory evoked potentials (SEPs) recorded at 1.5-Hz stimulation rate, where all the early components should be identifiable. We built a four-dipole model, which was issued from the grand average, and applied it also to recordings from single individuals. Our model included a dipole at the base of the skull and three other perirolandic dipoles. The first of the latter dipoles was tangentially oriented and was active at the same latencies as the N20/P20 potential and, with opposite polarity, the P24/N24 response. The second perirolandic dipole showed an initial peak of activity slightly earlier than that of the N20/P20 dipolar source and, later, it was active at the same latency as the central P22 potential. Lastly, the third perirolandic dipole explaining the fronto-central N30 potential scalp distribution was constantly more posterior than the first one. In order to evaluate the effect of an increasing repetition frequency on the activity of SEP dipolar sources, we applied the model built from 1.5-Hz SEPs to traces recorded at 3-Hz and 10-Hz repetition rates. We found that the 10-Hz stimulus frequency reduced selectively the later of the two activity phases of the first perirolandic dipole. The decrement in strength of this dipolar source can be explained if we assume that: (a) the later activity of the first perirolandic dipole can represent the inhibitory phase of a "primary response"; (b) two different clusters of cells generate the opposite activities of the tangential perirolandic dipole. An additional finding in our model was that two different perirolandic dipoles contribute to the centro-parietal N20 potential generation.

Reconciling Biodiversity Conservation and Widespread Deployment of Renewable Energy Technologies in the UK

PubMed Central

Gove, Benedict; Williams, Leah J.; Beresford, Alison E.; Roddis, Philippa; Campbell, Colin; Teuten, Emma; Langston, Rowena H. W.; Bradbury, Richard B.

2016-01-01

Renewable energy will potentially make an important contribution towards the dual aims of meeting carbon emission reduction targets and future energy demand. However, some technologies have considerable potential to impact on the biodiversity of the environments in which they are placed. In this study, an assessment was undertaken of the realistic deployment potential of a range of renewable energy technologies in the UK, considering constraints imposed by biodiversity conservation priorities. We focused on those energy sources that have the potential to make important energy contributions but which might conflict with biodiversity conservation objectives. These included field-scale solar, bioenergy crops, wind energy (both onshore and offshore), wave and tidal stream energy. The spatially-explicit analysis considered the potential opportunity available for each technology, at various levels of ecological risk. The resultant maps highlight the energy resource available, physical and policy constraints to deployment, and ecological sensitivity (based on the distribution of protected areas and sensitive species). If the technologies are restricted to areas which currently appear not to have significant ecological constraints, the total potential energy output from these energy sources was estimated to be in the region of 5,547 TWh/yr. This would be sufficient to meet projected energy demand in the UK, and help to achieve carbon reduction targets. However, we highlight two important caveats. First, further ecological monitoring and surveillance is required to improve understanding of wildlife distributions and therefore potential impacts of utilising these energy sources. This is likely to reduce the total energy available, especially at sea. Second, some of the technologies under investigation are currently not deployed commercially. Consequently this potential energy will only be available if continued effort is put into developing these energy sources/technologies, to enable realisation of their full potential. PMID:27224050

Reconciling Biodiversity Conservation and Widespread Deployment of Renewable Energy Technologies in the UK.

PubMed

Gove, Benedict; Williams, Leah J; Beresford, Alison E; Roddis, Philippa; Campbell, Colin; Teuten, Emma; Langston, Rowena H W; Bradbury, Richard B

2016-01-01

Renewable energy will potentially make an important contribution towards the dual aims of meeting carbon emission reduction targets and future energy demand. However, some technologies have considerable potential to impact on the biodiversity of the environments in which they are placed. In this study, an assessment was undertaken of the realistic deployment potential of a range of renewable energy technologies in the UK, considering constraints imposed by biodiversity conservation priorities. We focused on those energy sources that have the potential to make important energy contributions but which might conflict with biodiversity conservation objectives. These included field-scale solar, bioenergy crops, wind energy (both onshore and offshore), wave and tidal stream energy. The spatially-explicit analysis considered the potential opportunity available for each technology, at various levels of ecological risk. The resultant maps highlight the energy resource available, physical and policy constraints to deployment, and ecological sensitivity (based on the distribution of protected areas and sensitive species). If the technologies are restricted to areas which currently appear not to have significant ecological constraints, the total potential energy output from these energy sources was estimated to be in the region of 5,547 TWh/yr. This would be sufficient to meet projected energy demand in the UK, and help to achieve carbon reduction targets. However, we highlight two important caveats. First, further ecological monitoring and surveillance is required to improve understanding of wildlife distributions and therefore potential impacts of utilising these energy sources. This is likely to reduce the total energy available, especially at sea. Second, some of the technologies under investigation are currently not deployed commercially. Consequently this potential energy will only be available if continued effort is put into developing these energy sources/technologies, to enable realisation of their full potential.

Speed of CMEs and the Magnetic Non-Potentiality of their Source Active Regions

NASA Technical Reports Server (NTRS)

Tiwari, Sanjiv Kumar; Falconer, David Allen; Moore, Ronald L.; Venkatakrishnan, P.; Winebarger, Amy R.; Khazanov, Igor G.

2014-01-01

Most fast coronal mass ejections (CMEs) originate from solar active regions (ARs). Non-potentiality of ARs plausibly determines the speed of CMEs in the outer corona. Several other unexplored parameters might be important as well. To find out the relation between the intial speed of CMEs and the non-potentiality of source ARs, we identified over a hundred of CMEs with source ARs via their co-produced flares. The speed of the CMEs are collected from the SOHO LASCO CME catalog. We have used vector magnetograms obtained with HMI/SDO, to evaluate various magnetic non-potentiality parameters, e.g. magnetic free-energy proxies, twist, shear angle, signed shear angle, net current etc. We have also included several other parameters e.g. total unsigned flux, magnetic area of ARs, area of sunspots, to investigate their correlation, if any, with the initial speeds of CMEs. Our preliminary results show that the ARs with larger non-potentiality and area produce faster CMEs but they can also produce slow ones. The ARs with lesser non-potentiality and area generally produce only slower CMEs.

Hydrocarbon Source Rocks in the Deep River and Dan River Triassic Basins, North Carolina

USGS Publications Warehouse

Reid, Jeffrey C.; Milici, Robert C.

2008-01-01

This report presents an interpretation of the hydrocarbon source rock potential of the Triassic sedimentary rocks of the Deep River and Dan River basins, North Carolina, based on previously unpublished organic geochemistry data. The organic geochemical data, 87 samples from 28 drill holes, are from the Sanford sub-basin (Cumnock Formation) of the Deep River basin, and from the Dan River basin (Cow Branch Formation). The available organic geochemical data are biased, however, because many of the samples collected for analyses by industry were from drill holes that contained intrusive diabase dikes, sills, and sheets of early Mesozoic age. These intrusive rocks heated and metamorphosed the surrounding sediments and organic matter in the black shale and coal bed source rocks and, thus, masked the source rock potential that they would have had in an unaltered state. In places, heat from the intrusives generated over-mature vitrinite reflectance (%Ro) profiles and metamorphosed the coals to semi-anthracite, anthracite, and coke. The maximum burial depth of these coal beds is unknown, and depth of burial may also have contributed to elevated thermal maturation profiles. The organic geochemistry data show that potential source rocks exist in the Sanford sub-basin and Dan River basin and that the sediments are gas prone rather than oil prone, although both types of hydrocarbons were generated. Total organic carbon (TOC) data for 56 of the samples are greater than the conservative 1.4% TOC threshold necessary for hydrocarbon expulsion. Both the Cow Branch Formation (Dan River basin) and the Cumnock Formation (Deep River basin, Sanford sub-basin) contain potential source rocks for oil, but they are more likely to have yielded natural gas. The organic material in these formations was derived primarily from terrestrial Type III woody (coaly) material and secondarily from lacustrine Type I (algal) material. Both the thermal alteration index (TAI) and vitrinite reflectance data (%Ro) indicate levels of thermal maturity suitable for generation of hydrocarbons. The genetic potential of the source rocks in these Triassic basins is moderate to high and many source rock sections have at least some potential for hydrocarbon generation. Some data for the Cumnock Formation indicate a considerably higher source rock potential than the basin average, with S1 + S2 data in the mid-20 mg HC/g sample range, and some hydrocarbons have been generated. This implies that the genetic potential for all of these strata may have been higher prior to the igneous activity. However, the intergranular porosity and permeability of the Triassic strata are low, which makes fractured reservoirs more attractive as drilling targets. In some places, gravity and magnetic surveys that are used to locate buried intrusive rock may identify local thermal sources that have facilitated gas generation. Alternatively, awareness of the distribution of large intrusive igneous bodies at depth may direct exploration into other areas, where thermal maturation is less than the limits of hydrocarbon destruction. Areas prospective for natural gas also contain large surficial clay resources and any gas discovered could be used as fuel for local industries that produce clay products (principally brick), as well as fuel for other local industries.

A new DG nanoscale TFET based on MOSFETs by using source gate electrode: 2D simulation and an analytical potential model

NASA Astrophysics Data System (ADS)

Ramezani, Zeinab; Orouji, Ali A.

2017-08-01

This paper suggests and investigates a double-gate (DG) MOSFET, which emulates tunnel field effect transistors (M-TFET). We have combined this novel concept into a double-gate MOSFET, which behaves as a tunneling field effect transistor by work function engineering. In the proposed structure, in addition to the main gate, we utilize another gate over the source region with zero applied voltage and a proper work function to convert the source region from N+ to P+. We check the impact obtained by varying the source gate work function and source doping on the device parameters. The simulation results of the M-TFET indicate that it is a suitable case for a switching performance. Also, we present a two-dimensional analytic potential model of the proposed structure by solving the Poisson's equation in x and y directions and by derivatives from the potential profile; thus, the electric field is achieved. To validate our present model, we use the SILVACO ATLAS device simulator. The analytical results have been compared with it.

AGRICULTURAL NONPOINT SOURCE POLLUTION (AGNPS)

EPA Science Inventory

Developed by the USDA Agricultural Research Service, Agricultural Nonpoint Source Pollution (AGNPS) model addresses concerns related to the potential impacts of point and nonpoint source pollution on surface and groundwater quality (Young et al., 1989). It was designed to quantit...

Source Water Assessment for the Las Vegas Valley Surface Waters

NASA Astrophysics Data System (ADS)

Albuquerque, S. P.; Piechota, T. C.

2003-12-01

The 1996 amendment to the Safe Drinking Water Act of 1974 created the Source Water Assessment Program (SWAP) with an objective to evaluate potential sources of contamination to drinking water intakes. The development of a Source Water Assessment Plan for Las Vegas Valley surface water runoff into Lake Mead is important since it will guide future work on source water protection of the main source of water. The first step was the identification of the watershed boundary and source water protection area. Two protection zones were delineated. Zone A extends 500 ft around water bodies, and Zone B extends 3000 ft from the boundaries of Zone A. These Zones extend upstream to the limits of dry weather flows in the storm channels within the Las Vegas Valley. After the protection areas were identified, the potential sources of contamination in the protection area were inventoried. Field work was conducted to identify possible sources of contamination. A GIS coverage obtained from local data sources was used to identify the septic tank locations. Finally, the National Pollutant Discharge Elimination System (NPDES) Permits were obtained from the State of Nevada, and included in the inventory. After the inventory was completed, a level of risk was assigned to each potential contaminating activity (PCA). The contaminants of concern were grouped into five categories: volatile organic compounds (VOCs), synthetic organic compounds (SOCs), inorganic compounds (IOCs), microbiological, and radionuclides. The vulnerability of the water intake to each of the PCAs was assigned based on these five categories, and also on three other factors: the physical barrier effectiveness, the risk potential, and the time of travel. The vulnerability analysis shows that the PCAs with the highest vulnerability rating include septic systems, golf courses/parks, storm channels, gas stations, auto repair shops, construction, and the wastewater treatment plant discharges. Based on the current water quality data (prior to treatment), the proximity of Las Vegas Wash to the intake, and the results of the vulnerability analysis of potential contaminating activities, it is determined that the drinking water intake is at a Moderate level of risk for VOC, SOC, and microbiological contaminants. The drinking water intake is at a High level of risk for IOC contaminants. Vulnerability to radiological contamination is Moderate. Source water protection in the Las Vegas Valley is strongly encouraged because of the documented influence of the Las Vegas Wash on the quality of the water at the intake.

A conceptual ground-water-quality monitoring network for San Fernando Valley, California

USGS Publications Warehouse

Setmire, J.G.

1985-01-01

A conceptual groundwater-quality monitoring network was developed for San Fernando Valley to provide the California State Water Resources Control Board with an integrated, basinwide control system to monitor the quality of groundwater. The geology, occurrence and movement of groundwater, land use, background water quality, and potential sources of pollution were described and then considered in designing the conceptual monitoring network. The network was designed to monitor major known and potential point and nonpoint sources of groundwater contamination over time. The network is composed of 291 sites where wells are needed to define the groundwater quality. The ideal network includes four specific-purpose networks to monitor (1) ambient water quality, (2) nonpoint sources of pollution, (3) point sources of pollution, and (4) line sources of pollution. (USGS)

Spherical-earth Gravity and Magnetic Anomaly Modeling by Gauss-legendre Quadrature Integration

NASA Technical Reports Server (NTRS)

Vonfrese, R. R. B.; Hinze, W. J.; Braile, L. W.; Luca, A. J. (Principal Investigator)

1981-01-01

The anomalous potential of gravity and magnetic fields and their spatial derivatives on a spherical Earth for an arbitrary body represented by an equivalent point source distribution of gravity poles or magnetic dipoles were calculated. The distribution of equivalent point sources was determined directly from the coordinate limits of the source volume. Variable integration limits for an arbitrarily shaped body are derived from interpolation of points which approximate the body's surface envelope. The versatility of the method is enhanced by the ability to treat physical property variations within the source volume and to consider variable magnetic fields over the source and observation surface. A number of examples verify and illustrate the capabilities of the technique, including preliminary modeling of potential field signatures for Mississippi embayment crustal structure at satellite elevations.

Petroleum source potential of the Lower Cretaceous mudstone succession of the NPRA and Colville Delta area, North Slope Alaska, based on sonic and resistivity logs

USGS Publications Warehouse

Keller, Margaret A.; Bird, Kenneth J.

2003-01-01

Resource assessment of the North Slope of Alaska by the U. S. Geological Survey includes evaluation of the petroleum source potential of Mesozoic and Cenozoic rocks using the delta log R technique (Passey and others, 1990). Porosity and resistivity logs are used in combination with thermal maturity data to produce a continuous profile of total organic carbon content in weight % (TOC). From the pattern and amount of TOC in the profile produced, the depositional setting and thus the petroleum source-rock potential (kerogen type) of the organic matter can be inferred and compared to interpretations from other data such as Rock-Eval pyrolysis. TOC profiles determined by this technique for the contiguous interval of pebble shale unit, Hue Shale (including the Gamma Ray Zone or GRZ), and lower part of the Torok Formation indicate important potential for petroleum generation in the Tunalik 1, Inigok 1, N. Inigok 1, Kuyanak 1, Texaco Colville Delta 1, Nechelik 1, and Bergschrund 1 wells of the western North Slope region. TOC profiles suggest that this interval contains both type II and III kerogens – consistent with proposed depositional models -- and is predominantly greater than 2 wt. % TOC (cut-off used for effective source potential). Average TOC for the total effective section of the pebble shale unit + Hue Shale ranges from 2.6 to 4.1 wt % TOC (values predominantly 2-8% TOC) over 192-352 ft. Source potential for the lower Torok Formation, which also has interbedded sandstone and lean mudstone, is good to negligible in these 7 wells.

Directional interstitial brachytherapy from simulation to application

NASA Astrophysics Data System (ADS)

Lin, Liyong

Organs at risk (OAR) are sometimes adjacent to or embedded in or overlap with the clinical target volume (CTV) to be treated. The purpose of this PhD study is to develop directionally low energy gamma-emitting interstitial brachytherapy sources. These sources can be applied between OAR to selectively reduce hot spots in the OARs and normal tissues. The reduction of dose over undesired regions can expand patient eligibility or reduce toxicities for the treatment by conventional interstitial brachytherapy. This study covers the development of a directional source from design optimization to construction of the first prototype source. The Monte Carlo code MCNP was used to simulate the radiation transport for the designs of directional sources. We have made a special construction kit to assemble radioactive and gold-shield components precisely into D-shaped titanium containers of the first directional source. Directional sources have a similar dose distribution as conventional sources on the treated side but greatly reduced dose on the shielded side, with a sharp dose gradient between them. A three-dimensional dose deposition kernel for the 125I directional source has been calculated. Treatment plans can use both directional and conventional 125I sources at the same source strength for low-dose-rate (LDR) implants to optimize the dose distributions. For prostate tumors, directional 125I LDR brachytherapy can potentially reduce genitourinary and gastrointestinal toxicities and improve potency preservation for low risk patients. The combination of better dose distribution of directional implants and better therapeutic ratio between tumor response and late reactions enables a novel temporary LDR treatment, as opposed to permanent or high-dose-rate (HDR) brachytherapy for the intermediate risk T2b and high risk T2c tumors. Supplemental external-beam treatments can be shortened with a better brachytherapy boost for T3 tumors. In conclusion, we have successfully finished the design optimization and construction of the first prototype directional source. Potential clinical applications and potential benefits of directional sources have been shown for prostate and breast tumors.

Very-low-energy-spread ion sources

NASA Astrophysics Data System (ADS)

Lee, Y.

1997-05-01

Ion beams with low axial energy spread are required in many applications such as ion projection lithography, isobaric separation in radioactive ion beam experiments, and ion beam deposition processes. In an ion source, the spread of the axial ion energy is caused by the nonuniformity of the plasma potential distribution along the source axis. Multicusp ion sources are capable of production positive and negative ions with good beam quality and relatively low energy spread. By intorducing a magnetic filter inside the multicusp source chamber, the axial plasma potential distribution is modified and the energy spread of positive hydrogen ions can be reduced to as low as 1 eV. The energy spread measurements of multicusp sources have been conducted by employing three different techniques: an electrostatic energy analyzer at the source exit; a magnetic deflection spectrometer; and a retarding-field energy analyzer for the accelerated beam. These different measurements confirmed tha! t ! the axial energy spread of positive and negative ions generated in the filter-equipped multicusp sources are small. New ion source configurations are now being investigated at LBNL with the purpose of achieving enen lower energy spread (<1eV) and of maximizing source performance such as reliability and lifetime.

Photovoltaics as a terrestrial energy source. Volume 1: An introduction

NASA Technical Reports Server (NTRS)

Smith, J. L.

1980-01-01

Photovoltaic (PV) systems were examined their potential for terrestrial application and future development. Photovoltaic technology, existing and potential photovoltaic applications, and the National Photovoltaics Program are reviewed. The competitive environment for this electrical source, affected by the presence or absence of utility supplied power is evaluated in term of systems prices. The roles of technological breakthroughs, directed research and technology development, learning curves, and commercial demonstrations in the National Program are discussed. The potential for photovoltaics to displace oil consumption is examined, as are the potential benefits of employing PV in either central-station or non-utility owned, small, distributed systems.

Water quality modeling using geographic information system (GIS) data

NASA Technical Reports Server (NTRS)

Engel, Bernard A

1992-01-01

Protection of the environment and natural resources at the Kennedy Space Center (KSC) is of great concern. The potential for surface and ground water quality problems resulting from non-point sources of pollution was examined using models. Since spatial variation of parameters required was important, geographic information systems (GIS) and their data were used. The potential for groundwater contamination was examined using the SEEPAGE (System for Early Evaluation of the Pollution Potential of Agricultural Groundwater Environments) model. A watershed near the VAB was selected to examine potential for surface water pollution and erosion using the AGNPS (Agricultural Non-Point Source Pollution) model.

A NEW HIGH RESOLUTION MASS SPECTROMETRY TECHNIQUE FOR IDENTIFYING PHARMACEUTICALS AND POTENTIAL ENDOCRINE DISRUPTORS IN DRINKING WATER SOURCES

EPA Science Inventory

A New High Resolution Mass Spectrometry Technique for Identifying Pharmaceuticals and Potential Endocrine Disruptors in Drinking Water Sources

Andrew H. Grange and G. Wayne Sovocool U.S.EPA, ORD, NERL, ESD, ECB, P.O. Box 93478, Las Vegas, NV 891933478

Mass spectra...

Assessment of potential oil and gas resources in source rocks of the Alaska North Slope, 2012

USGS Publications Warehouse

Houseknecht, David W.; Rouse, William A.; Garrity, Christopher P.; Whidden, Katherine J.; Dumoulin, Julie A.; Schenk, Christopher J.; Charpentier, Ronald R.; Cook, Troy A.; Gaswirth, Stephanie B.; Kirschbaum, Mark A.; Pollastro, Richard M.

2012-01-01

The U.S. Geological Survey estimated potential, technically recoverable oil and gas resources for source rocks of the Alaska North Slope. Estimates (95-percent to 5-percent probability) range from zero to 2 billion barrels of oil and from zero to nearly 80 trillion cubic feet of gas.

40 CFR Table 10 to Subpart Eeee of... - Continuous Compliance With Work Practice Standards

Code of Federal Regulations, 2010 CFR

2010-07-01

... liquids, operate a vapor balancing system. i. Monitoring each potential source of vapor leakage in the... requirements of 40 CFR part 63, subpart TT, UU, or H. i. Carrying out a leak detection and repair program in... relief devices, monitoring each potential source of vapor leakage in the system, including, but not...

Effectiveness of forestry BMPS for stream crossing sediment reduction using rainfall simulation

Treesearch

Brian C. Morris; M. Chad Bolding; W. Michael Aust

2015-01-01

Recent decisions by the United States Supreme Court and United States Environmental Protection Agency (EPA) have re-emphasized the importance of forestry best management practices (BMPs) at stream crossings. Stream crossings are potential major sources of sediment due to their direct connectivity between the potential erosion source and the stream, which eliminates...

Youth Participatory Action Research and Educational Transformation: The Potential of Intertextuality as a Methodological Tool

ERIC Educational Resources Information Center

Bertrand, Melanie

2016-01-01

In this article, Melanie Bertrand explores the potential of using the concept of intertextuality--which captures the way snippets of written or spoken text from one source become incorporated into other sources--in the study and practice of youth participatory action research (YPAR). Though this collective and youth-centered form of research…

Processing use, and characterization of shale oil products

PubMed Central

Decora, Andrew W.; Kerr, Robert D.

1979-01-01

Oil shale is a potential source of oil that will supplement conventional sources for oil as our needs for fossil fuels begin to exceed our supplies. The resource may be mined and processed on the surface or it may be processed in situ. An overview of the potential technologies and environmental issues is presented. PMID:446454

APPARATUS FOR PRODUCING HIGH VELOCITY SHOCK WAVES IN GASES

DOEpatents

Scott, F.R.; Josephson, V.

1960-02-01

>A device for producing a high-energy ionized gas region comprises an evacuated tapered insulating vessel and a substantially hemispherical insulating cap hermetically affixed to the large end of the vessel, an annular electrode having a diameter equal to and supported in the interior wall of the vessel at the large end and having a conductive portion inside the vessel, a second electrode supported at the small end of the vessel, means connected to the vessel for introducing a selected gas therein, a source of high potential having two poles. means for connecting one pole of the high potential source to the annular electrode, and means for connecting the other pole of the potential source to the second electrode.

Healthcare Engagement as a Potential Source of Psychological Distress among People without Religious Beliefs: A Systematic Review

PubMed Central

Weber, Samuel R.; Lomax, James W.; Pargament, Kenneth I.

2017-01-01

Research into religion and mental health is increasing, but nonbelievers in terms of religion are often overlooked. Research has shown that nonbelievers experience various forms of psychological distress and that the negative perception of nonbelievers by others is a potential source of distress. This review builds on that research by identifying another potential source of psychological distress for nonbelievers: engagement with the healthcare system. Poor understanding of nonbelievers by healthcare professionals may lead to impaired communication in the healthcare setting, resulting in distress. Attempts by nonbelievers to avoid distress may result in different patterns of healthcare utilization. Awareness of these concerns may help healthcare providers to minimize distress among their nonbelieving patients. PMID:28379161

Healthcare Engagement as a Potential Source of Psychological Distress among People without Religious Beliefs: A Systematic Review.

PubMed

Weber, Samuel R; Lomax, James W; Pargament, Kenneth I

2017-04-05

Research into religion and mental health is increasing, but nonbelievers in terms of religion are often overlooked. Research has shown that nonbelievers experience various forms of psychological distress and that the negative perception of nonbelievers by others is a potential source of distress. This review builds on that research by identifying another potential source of psychological distress for nonbelievers: engagement with the healthcare system. Poor understanding of nonbelievers by healthcare professionals may lead to impaired communication in the healthcare setting, resulting in distress. Attempts by nonbelievers to avoid distress may result in different patterns of healthcare utilization. Awareness of these concerns may help healthcare providers to minimize distress among their nonbelieving patients.

Fast Model Generalized Pseudopotential Theory Interatomic Potential Routine

DOE Office of Scientific and Technical Information (OSTI.GOV)

2015-03-18

MGPT is an unclassified source code for the fast evaluation and application of quantum-based MGPT interatomic potentials for mrtals. The present version of MGPT has been developed entirely at LLNL, but is specifically designed for implementation in the open-source molecular0dynamics code LAMMPS maintained by Sandia National Laboratories. Using MGPT in LAMMPS, with separate input potential data, one can perform large-scale atomistic simulations of the structural, thermodynamic, defeat and mechanical properties of transition metals with quantum-mechanical realism.

Building Assessment Survey and Evaluation Study: Summarized Data - Test Space Pollutant Sources

EPA Pesticide Factsheets

information collected regarding sources that may have potential impact on the building in terms of indoor air quality including sources such as past or current water damage, pesticide application practices, special use spaces, etc.

Investigation of hydraulic transmission noise sources

NASA Astrophysics Data System (ADS)

Klop, Richard J.

Advanced hydrostatic transmissions and hydraulic hybrids show potential in new market segments such as commercial vehicles and passenger cars. Such new applications regard low noise generation as a high priority, thus, demanding new quiet hydrostatic transmission designs. In this thesis, the aim is to investigate noise sources of hydrostatic transmissions to discover strategies for designing compact and quiet solutions. A model has been developed to capture the interaction of a pump and motor working in a hydrostatic transmission and to predict overall noise sources. This model allows a designer to compare noise sources for various configurations and to design compact and inherently quiet solutions. The model describes dynamics of the system by coupling lumped parameter pump and motor models with a one-dimensional unsteady compressible transmission line model. The model has been verified with dynamic pressure measurements in the line over a wide operating range for several system structures. Simulation studies were performed illustrating sensitivities of several design variables and the potential of the model to design transmissions with minimal noise sources. A semi-anechoic chamber has been designed and constructed suitable for sound intensity measurements that can be used to derive sound power. Measurements proved the potential to reduce audible noise by predicting and reducing both noise sources. Sound power measurements were conducted on a series hybrid transmission test bench to validate the model and compare predicted noise sources with sound power.

Analysis of Discontinuities in a Rectangular Waveguide Using Dyadic Green's Function Approach in Conjunction with Method of Moments

NASA Technical Reports Server (NTRS)

Deshpande, M. D.

1997-01-01

The dyadic Green's function for an electric current source placed in a rectangular waveguide is derived using a magnetic vector potential approach. A complete solution for the electric and magnetic fields including the source location is obtained by simple differentiation of the vector potential around the source location. The simple differentiation approach which gives electric and magnetic fields identical to an earlier derivation is overlooked by the earlier workers in the derivation of the dyadic Green's function particularly around the source location. Numerical results obtained using the Green's function approach are compared with the results obtained using the Finite Element Method (FEM).

International Conference on Problems Related to the Stratosphere

NASA Technical Reports Server (NTRS)

Huntress, W., Jr.

1977-01-01

The conference focused on four main areas of investigation: laboratory studies and stratospheric chemistry and constituents, sources for and chemical budget of stratospheric halogen compounds, sources for and chemical budget of stratospheric nitrous oxide, and the dynamics of decision making on regulation of potential pollutants of the stratosphere. Abstracts of the scientific sessions of the conference as well as complete transcriptions of the panel discussions on sources for an atmospheric budget of holocarbons and nitrous oxide are included. The political, social and economic issues involving regulation of potential stratospheric pollutants were examined extensively.

Nanomaterials and nanoparticles: sources and toxicity.

PubMed

Buzea, Cristina; Pacheco, Ivan I; Robbie, Kevin

2007-12-01

This review is presented as a common foundation for scientists interested in nanoparticles, their origin,activity, and biological toxicity. It is written with the goal of rationalizing and informing public health concerns related to this sometimes-strange new science of "nano," while raising awareness of nanomaterials' toxicity among scientists and manufacturers handling them.We show that humans have always been exposed to tiny particles via dust storms, volcanic ash, and other natural processes, and that our bodily systems are well adapted to protect us from these potentially harmful intruders. There ticuloendothelial system, in particular, actively neutralizes and eliminates foreign matter in the body,including viruses and nonbiological particles. Particles originating from human activities have existed for millennia, e.g., smoke from combustion and lint from garments, but the recent development of industry and combustion-based engine transportation has profoundly increased an thropogenic particulate pollution. Significantly, technological advancement has also changed the character of particulate pollution, increasing the proportion of nanometer-sized particles--"nanoparticles"--and expanding the variety of chemical compositions. Recent epidemiological studies have shown a strong correlation between particulate air pollution levels, respiratory and cardiovascular diseases, various cancers, and mortality. Adverse effects of nanoparticles on human health depend on individual factors such as genetics and existing disease, as well as exposure, and nanoparticle chemistry, size, shape,agglomeration state, and electromagnetic properties. Animal and human studies show that inhaled nanoparticles are less efficiently removed than larger particles by the macrophage clearance mechanisms in the lungs, causing lung damage, and that nanoparticles can translocate through the circulatory, lymphatic, and nervous systems to many tissues and organs, including the brain. The key to understanding the toxicity of nanoparticles is that their minute size, smaller than cells and cellular organelles, allows them to penetrate these basic biological structures, disrupting their normal function.Examples of toxic effects include tissue inflammation, and altered cellular redox balance toward oxidation, causing abnormal function or cell death. The manipulation of matter at the scale of atoms,"nanotechnology," is creating many new materials with characteristics not always easily predicted from current knowledge. Within the nearly limitless diversity of these materials, some happen to be toxic to biological systems, others are relatively benign, while others confer health benefits. Some of these materials have desirable characteristics for industrial applications, as nanostructured materials often exhibit beneficial properties, from UV absorbance in sunscreen to oil-less lubrication of motors.A rational science-based approach is needed to minimize harm caused by these materials, while supporting continued study and appropriate industrial development. As current knowledge of the toxicology of "bulk" materials may not suffice in reliably predicting toxic forms of nanoparticles,ongoing and expanded study of "nanotoxicity" will be necessary. For nanotechnologies with clearly associated health risks, intelligent design of materials and devices is needed to derive the benefits of these new technologies while limiting adverse health impacts. Human exposure to toxic nanoparticles can be reduced through identifying creation-exposure pathways of toxins, a study that may someday soon unravel the mysteries of diseases such as Parkinson's and Alzheimer's. Reduction in fossil fuel combustion would have a large impact on global human exposure to nanoparticles, as would limiting deforestation and desertification.While nanotoxicity is a relatively new concept to science, this review reveals the result of life's long history of evolution in the presence of nanoparticles, and how the human body, in particular, has adapted to defend itself against nanoparticulate intruders. 2007 American Vacuum Society.

Using oxygen isotopes of phosphate to trace phosphorus sources and cycling in lake Erie

USGS Publications Warehouse

Elsbury, K.E.; Paytan, A.; Ostrom, N.E.; Kendall, C.; Young, M.B.; McLaughlin, K.; Rollog, M.E.; Watson, S.

2009-01-01

Water samples collected during three sampling trips to Lake Erie displayed oxygen isotopic values of dissolved phosphate (??18O p) that were largely out of equilibrium with ambient conditions, indicating that source signatures may be discerned. ??18O p values in the Lake ranged from +10??? to +17???, whereas the equilibrium value was expected to be around +14???. The riverine weighted average ??18Op value was +11??? and may represent one source of phosphate to the Lake. The lake ?? 18Op values indicated that there must be one or more as yet uncharacterized source(s) of phosphate with a high ?? 18Op value. Potential sources other than rivers are not yet well-characterized with respect to ??18O of phosphate, but we speculate that a likely source may be the release of phosphate from sediments under reducing conditions created during anoxic events in the hypolimnion of the central basin of Lake Erie. Identifying potential phosphorus sources to the Lake is vital for designing effective management plans for reducing nutrient inputs and associated eutrophication. ?? 2009 American Chemical Society.

Resistivity and self-potential tomography applied to groundwater remediation and contaminant plumes: Sandbox and field experiments

NASA Astrophysics Data System (ADS)

Mao, D.; Revil, A.; Hort, R. D.; Munakata-Marr, J.; Atekwana, E. A.; Kulessa, B.

2015-11-01

Geophysical methods can be used to remotely characterize contaminated sites and monitor in situ enhanced remediation processes. We have conducted one sandbox experiment and one contaminated field investigation to show the robustness of electrical resistivity tomography and self-potential (SP) tomography for these applications. In the sandbox experiment, we injected permanganate in a trichloroethylene (TCE)-contaminated environment under a constant hydraulic gradient. Inverted resistivity tomograms are able to track the evolution of the permanganate plume in agreement with visual observations made on the side of the tank. Self-potential measurements were also performed at the surface of the sandbox using non-polarizing Ag-AgCl electrodes. These data were inverted to obtain the source density distribution with and without the resistivity information. A compact horizontal dipole source located at the front of the plume was obtained from the inversion of these self-potential data. This current dipole may be related to the redox reaction occurring between TCE and permanganate and the strong concentration gradient at the front of the plume. We demonstrate that time-lapse self-potential signals can be used to track the kinetics of an advecting oxidizer plume with acceptable accuracy and, if needed, in real time, but are unable to completely resolve the shape of the plume. In the field investigation, a 3D resistivity tomography is used to characterize an organic contaminant plume (resistive domain) and an overlying zone of solid waste materials (conductive domain). After removing the influence of the streaming potential, the identified source current density had a magnitude of 0.5 A m-2. The strong source current density may be attributed to charge movement between the neighboring zones that encourage abiotic and microbially enhanced reduction and oxidation reactions. In both cases, the self-potential source current density is located in the area of strong resistivity gradient.

Source identification and apportionment of halogenated compounds observed at a remote site in East Asia.

PubMed

Li, Shanlan; Kim, Jooil; Park, Sunyoung; Kim, Seung-Kyu; Park, Mi-Kyung; Mühle, Jens; Lee, Gangwoong; Lee, Meehye; Jo, Chun Ok; Kim, Kyung-Ryul

2014-01-01

The sources of halogenated compounds in East Asia associated with stratospheric ozone depletion and climate change are relatively poorly understood. High-precision in situ measurements of 18 halogenated compounds and carbonyl sulfide (COS) made at Gosan, Jeju Island, Korea, from November 2007 to December 2011 were analyzed by a positive matrix factorization (PMF). Seven major industrial sources were identified from the enhanced concentrations of halogenated compounds observed at Gosan and corresponding concentration-based source contributions were also suggested: primary aluminum production explaining 37% of total concentration enhancements, solvent usage of which source apportionment is 25%, fugitive emissions from HCFC/HFC production with 11%, refrigerant replacements (9%), semiconductor/electronics industry (9%), foam blowing agents (6%), and fumigation (3%). Statistical trajectory analysis was applied to specify the potential emission regions for seven sources using back trajectories. Primary aluminum production, solvent usage and fugitive emission sources were mainly contributed by China. Semiconductor/electronics sources were dominantly located in Korea. Refrigerant replacement, fumigation and foam blowing agent sources were spread throughout East Asian countries. The specified potential source regions are consistent with country-based consumptions and emission patterns, verifying the PMF analysis results. The industry-based emission sources of halogenated compounds identified in this study help improve our understanding of the East Asian countries' industrial contributions to halogenated compound emissions.

Application of a combined approach including contamination indexes, geographic information system and multivariate statistical models in levels, distribution and sources study of metals in soils in Northern China

PubMed Central

Huang, Kuixian; Luo, Xingzhang

2018-01-01

The purpose of this study is to recognize the contamination characteristics of trace metals in soils and apportion their potential sources in Northern China to provide a scientific basis for basic of soil environment management and pollution control. The data set of metals for 12 elements in surface soil samples was collected. The enrichment factor and geoaccumulation index were used to identify the general geochemical characteristics of trace metals in soils. The UNMIX and positive matrix factorizations (PMF) models were comparatively applied to apportion their potential sources. Furthermore, geostatistical tools were used to study the spatial distribution of pollution characteristics and to identify the affected regions of sources that were derived from apportionment models. The soils were contaminated by Cd, Hg, Pb and Zn to varying degree. Industrial activities, agricultural activities and natural sources were identified as the potential sources determining the contents of trace metals in soils with contributions of 24.8%–24.9%, 33.3%–37.2% and 38.0%–41.8%, respectively. The slightly different results obtained from UNMIX and PMF might be caused by the estimations of uncertainty and different algorithms within the models. PMID:29474412

Indicators reflecting local and transboundary sources of PM2.5 and PMCOARSE in Rome - Impacts in air quality

NASA Astrophysics Data System (ADS)

Dimitriou, Konstantinos; Kassomenos, Pavlos

2014-10-01

The keystone of this paper was to calculate and interpret indicators reflecting sources and air quality impacts of PM2.5 and PMCOARSE (PM10-PM2.5) in Rome (Italy), focusing on potential exogenous influences. A backward atmospheric trajectory cluster analysis was implemented. The likelihood of daily PM10 exceedances was studied in conjunction with atmospheric patterns, whereas a Potential Source Contribution Function (PSCF) based on air mass residence time was deployed on a grid of a 0.5° × 0.5° resolution. Higher PM2.5 concentrations were associated with short/medium range airflows originated from Balkan Peninsula, whereas potential PMCOARSE sources were localized across the Mediterranean and coastal North Africa, due to dust and sea spray transportation. According to the outcome of a daily Pollution Index (PI), a slightly increased degradation of air quality is induced due to the additional quantity of exogenous PM but nevertheless, average levels of PI in all trajectory clusters belong in the low pollution category. Gaseous and particulate pollutants were also elaborated by a Principal Component Analysis (PCA), which produced 4 components: [Traffic], [photochemical], [residential] and [Secondary Coarse Aerosol], reflecting local sources of air pollution. PM2.5 levels were strongly associated with traffic, whereas PMCOARSE were produced autonomously by secondary sources.

Neighborhood diversity of potentially pathogenic bacteria in drinking water from the city of Maroua, Cameroon.

PubMed

Healy-Profitós, Jessica; Lee, Seungjun; Mouhaman, Arabi; Garabed, Rebecca; Moritz, Mark; Piperata, Barbara; Lee, Jiyoung

2016-06-01

This study examined the spatial variation of potential gastrointestinal pathogens within drinking water sources and home storage containers in four neighborhoods in Maroua, Cameroon. Samples were collected from source (n = 28) and home containers (n = 60) in each study neighborhood. Pathogen contamination was assessed using quantitative polymerase chain reaction, targeting Campylobacter spp., Shiga toxin producing Escherichia coli (virulence genes, stx1 and stx2), and Salmonella spp. Microbial source tracking (MST) targeted three different host-specific markers: HF183 (human), Rum2Bac (ruminant) and GFD (poultry) to identify contamination sources. Staphylococcus aureus and the tetracycline-resistance gene (tetQ) were assessed to measure human hand contact and presence of antibiotic-resistant bacteria. Pathogen/MST levels were compared statistically and spatially, and neighborhood variation was compared with previously collected demographic information. All the test fecal markers and pathogens (except Arcobacter) were detected in home and source samples. Two neighborhoods tested positive for most pathogens/MST while the others only tested positive for one or two. Spatial variation of pathogens/MST existed between sources, storage containers, and neighborhoods. Differing population density and ethno-economic characteristics could potentially explain variation. Future research should explore the influence of demographic and ethno-economic factors on water quality during microbial risk assessments in urban Africa.

Potentially toxic trace element contamination, sources, and pollution assessment in farmlands, Bijie City, southwestern China.

PubMed

Yuan, Zhimin; Yao, Jun; Wang, Fei; Guo, Zunwei; Dong, Zeqin; Chen, Feng; Hu, Yu; Sunahara, Geoffrey

2017-01-01

Artisanal zinc smelting activities, which had been widely applied in Bijie City, Guizhou Province, southwestern of China, can pollute surrounding farmlands. In the present study, 177 farmland topsoil samples of Bijie City were collected and 11 potentially toxic trace elements (PTEs), namely Pb, Zn, Cu, Ni, Co, Mn, Cr, V, Hg, As, and Cd were tested to characterize the concentrations, sources, and ecological risks. Mean concentrations of these PTEs in soils were (mg/kg) as follows: Pb (127), Zn (379), Cu (93.1), Ni (54.6), Co (26.2), Mn (1095), Cr (133), V (206), Hg (0.15), As (16.2), and Cd (3.08). Pb, Zn, and Cd had coefficients of variation greater than 100% and showed a high uneven distribution and spatial variability in the study area. Correlation coefficient analysis and principal component analysis (PCA) were used to quantify potential pollution sources. Results showed that Cu, Ni, Co, Mn, and V came from natural sources, whereas Pb, Zn, Hg, As, and Cd came from anthropogenic pollution sources. Geoaccumulation index and potential ecological risk indices were employed to study the pollution degree of PTEs, which revealed that Pb and Cd shared the greatest contamination and would pose serious ecological risks to the surrounding environment. The results of this study could help the local government managers to establish pollution control strategies and to secure food safety.

WATER QUALITY IN SOURCE WATER, TREATMENT, AND DISTRIBUTION SYSTEMS

EPA Science Inventory

Most drinking water utilities practice the multiple-barrier concept as the guiding principle for providing safe water. This chapter discusses multiple barriers as they relate to the basic criteria for selecting and protecting source waters, including known and potential sources ...

The Characteristics and Potential Source Area Analysis of PM2.5 Concentration for Zhengzhou during 2016

NASA Astrophysics Data System (ADS)

Li, D.; Liu, J.; Li, S.; Wang, C.; Zhou, S.

2018-04-01

This study used the HYSPLIT-4 model combined with cluster analysis, potential source pollution contribution functions and other methods to analyse the ground air pollution monitoring data and meteorological data in Zhengzhou during 2016. The results showed that: 1) the level of PM2.5 reached the low value in summer. The PM2.5 concentration reached the highest level in December and reached the lowest level in August. The daily variation characteristics of PM2.5 concentration in different seasons were roughly the same, and it had an obviously "double-peak" structure. 2) The annual PM2.5 concentration was positively correlated with atmospheric pressure and relative humidity. The annual PM2.5 concentration was negatively correlated with temperature, visibility, precipitation, and wind speed. 3) In winter, the air mass trajectory that through the northern Sichuan - Gansu - Shaanxi - Hubei was polluted seriously, and the level of PM2.5 was the highest which reached to 202.13 μg/m3. In summer, the air mass trajectory that came from Hubei was the lowest level with the value is 40.17 μg/m3. 4) The potential source areas located in northwest of Zhengzhou, Gansu, Hubei and Beijing-Tianjin-Hebei region in spring. The surrounding of Zhengzhou contributed to the pollution of Zhengzhou. The potential source areas appeared in Shaanxi, Sichuan, and Qinghai, the border between Ningxia and Inner Mongolia in autumn. In winter the potential source areas located in Jiangsu, Hubei, Henan, eastern of Shanxi, southern of Shanxi, Ningxia and the area of Yellow Sea, etc.

The ecological risk, source identification, and pollution assessment of heavy metals in road dust: a case study in Rafsanjan, SE Iran.

PubMed

Mirzaei Aminiyan, Milad; Baalousha, Mohammed; Mousavi, Rouhollah; Mirzaei Aminiyan, Farzad; Hosseini, Hamideh; Heydariyan, Amin

2018-05-01

Heavy metal (HM) contamination in road dust is a potential environmental and human health threat. The sources, concentrations, spatial distribution, and ecological risk of As, Cd, Cu, Cr, Ni, Pb, and Zn in road dust in Rafsanjan City, Iran, were investigated. Pollution was assessed using the enrichment factor (EF). The potentially harmful effects of HMs were evaluated by calculating the potential ecological risk factor of individual metals (E r ) and of multiple metals (RI) using the Hakanson method. Correlation and principal component analyses (PCA) were applied to identify HM pollution sources. The concentrations of HMs in road dust were higher (ca. 5-10 folds) than their natural background values. The EF and E r increased according to the following order Cu > Pb > As > Zn > Cd > Cr > Ni and Cu > Cd > Pb > As > Ni > Zn > Cr, respectively. Thus, Cu is regarded as the pollutant of highest concern. Based on potential ecological risk index (RI) spatial distribution, all parts of Rafsanjan are characterized by significantly high potential ecological risk. HM concentration heat maps, PCA, and correlation analysis suggest that Cu, Pb, As, Cd, and Zn may have originated from the same source and follow the same spatial distribution pattern. These metals originated mainly from anthropogenic sources like copper mining and smelting plants, industrial and chemical activities, inordinate application of chemical fertilizers and pesticides in farmlands, and heavy traffic. Ni and Cr are likely to origniate from the industrial activities and traffic load in Rafsanjan City.

Hydrocarbon source potential of the Tanezzuft Formation, Murzuq Basin, south-west Libya: An organic geochemical approach

NASA Astrophysics Data System (ADS)

El Diasty, W. Sh.; El Beialy, S. Y.; Anwari, T. A.; Batten, D. J.

2017-06-01

A detailed organic geochemical study of 20 core and cuttings samples collected from the Silurian Tanezzuft Formation, Murzuq Basin, in the south-western part of Libya has demonstrated the advantages of pyrolysis geochemical methods for evaluating the source-rock potential of this geological unit. Rock-Eval pyrolysis results indicate a wide variation in source richness and quality. The basal Hot Shale samples proved to contain abundant immature to early mature kerogen type II/III (oil-gas prone) that had been deposited in a marine environment under terrigenous influence, implying good to excellent source rocks. Strata above the Hot Shale yielded a mixture of terrigenous and marine type III/II kerogen (gas-oil prone) at the same maturity level as the Hot Shale, indicating the presence of only poor to fair source rocks.

Determination of the Geometric Form of a Plane of a Tectonic Gap as the Inverse III-posed Problem of Mathematical Physics

NASA Astrophysics Data System (ADS)

Sirota, Dmitry; Ivanov, Vadim

2017-11-01

Any mining operations influence stability of natural and technogenic massifs are the reason of emergence of the sources of differences of mechanical tension. These sources generate a quasistationary electric field with a Newtonian potential. The paper reviews the method of determining the shape and size of a flat source field with this kind of potential. This common problem meets in many fields of mining: geological exploration mineral resources, ore deposits, control of mining by underground method, determining coal self-heating source, localization of the rock crack's sources and other applied problems of practical physics. This problems are ill-posed and inverse and solved by converting to Fredholm-Uryson integral equation of the first kind. This equation will be solved by A.N. Tikhonov regularization method.

Spherical loudspeaker array for local active control of sound.

PubMed

Rafaely, Boaz

2009-05-01

Active control of sound has been employed to reduce noise levels around listeners' head using destructive interference from noise-canceling sound sources. Recently, spherical loudspeaker arrays have been studied as multiple-channel sound sources, capable of generating sound fields with high complexity. In this paper, the potential use of a spherical loudspeaker array for local active control of sound is investigated. A theoretical analysis of the primary and secondary sound fields around a spherical sound source reveals that the natural quiet zones for the spherical source have a shell-shape. Using numerical optimization, quiet zones with other shapes are designed, showing potential for quiet zones with extents that are significantly larger than the well-known limit of a tenth of a wavelength for monopole sources. The paper presents several simulation examples showing quiet zones in various configurations.

Dependence of the source performance on plasma parameters at the BATMAN test facility

NASA Astrophysics Data System (ADS)

Wimmer, C.; Fantz, U.

2015-04-01

The investigation of the dependence of the source performance (high jH-, low je) for optimum Cs conditions on the plasma parameters at the BATMAN (Bavarian Test MAchine for Negative hydrogen ions) test facility is desirable in order to find key parameters for the operation of the source as well as to deepen the physical understanding. The most relevant source physics takes place in the extended boundary layer, which is the plasma layer with a thickness of several cm in front of the plasma grid: the production of H-, its transport through the plasma and its extraction, inevitably accompanied by the co-extraction of electrons. Hence, a link of the source performance with the plasma parameters in the extended boundary layer is expected. In order to characterize electron and negative hydrogen ion fluxes in the extended boundary layer, Cavity Ring-Down Spectroscopy and Langmuir probes have been applied for the measurement of the H- density and the determination of the plasma density, the plasma potential and the electron temperature, respectively. The plasma potential is of particular importance as it determines the sheath potential profile at the plasma grid: depending on the plasma grid bias relative to the plasma potential, a transition in the plasma sheath from an electron repelling to an electron attracting sheath takes place, influencing strongly the electron fraction of the bias current and thus the amount of co-extracted electrons. Dependencies of the source performance on the determined plasma parameters are presented for the comparison of two source pressures (0.6 Pa, 0.45 Pa) in hydrogen operation. The higher source pressure of 0.6 Pa is a standard point of operation at BATMAN with external magnets, whereas the lower pressure of 0.45 Pa is closer to the ITER requirements (p ≤ 0.3 Pa).

The Use of Original Sources and Its Potential Relation to the Recruitment Problem

ERIC Educational Resources Information Center

Jankvist, Uffe Thomas

2014-01-01

Based on a study about using original sources with Danish upper secondary students, the paper addresses the potential outcome of such an approach in regard to the so-called recruitment problem to the mathematical sciences. 24 students were exposed to questionnaire questions and 16 of these to follow-up interviews, which form the basis for both a…

Albiziahexoside: a potential source of bioactive saponin from the leaves of Albizzia lebbeck.

PubMed

Ueda, Minoru; Tokunaga, Takashi; Okazaki, Masayuki; Sata, Noriko U; Ueda, Katsuhiro; Yamamura, Shosuke

2003-10-01

Albiziahexoside (1), a new hexaglycosylated saponin, was isolated from leaves of Albizzia lebbeck. Saponin 1, which is an analog of cytotoxic albiziatrioside A (2), did not show cytotoxicity. However, 1 is a potential source of 2 and related bioactive saponins for medicinal use because leaves, which can be regenerated after collection, contain 1 in substantial quantity.

Do mitigation strategies reduce global warming potential in the northern U.S. Corn Belt?

USDA-ARS?s Scientific Manuscript database

Agriculture is both an anthropogenic source of CO2, CH4, and N2O, and a sink for CO2 and CH4. Management can impact agriculture's net global warming potential (GWP) by changing source and/or sink. This study compared GWP among three crop management systems: business as usual (BAU), optimum greenhous...

Stable isotopes of lead and strontium as tracers of sources of airborne particulate matter in Kyrgyzstan.

EPA Science Inventory

Central Asia is dominated by an arid climate and desert-like conditions, leading to the potential of long-range transport of desert dust. One potential source of dust to Central Asia is the Aral Sea, the surface area of which has receded in size from 68,000 km2 to 14,280 km2, lar...

On the role of glottis-interior sources in the production of voiced sound.

PubMed

Howe, M S; McGowan, R S

2012-02-01

The voice source is dominated by aeroacoustic sources downstream of the glottis. In this paper an investigation is made of the contribution to voiced speech of secondary sources within the glottis. The acoustic waveform is ultimately determined by the volume velocity of air at the glottis, which is controlled by vocal fold vibration, pressure forcing from the lungs, and unsteady backreactions from the sound and from the supraglottal air jet. The theory of aerodynamic sound is applied to study the influence on the fine details of the acoustic waveform of "potential flow" added-mass-type glottal sources, glottis friction, and vorticity either in the glottis-wall boundary layer or in the portion of the free jet shear layer within the glottis. These sources govern predominantly the high frequency content of the sound when the glottis is near closure. A detailed analysis performed for a canonical, cylindrical glottis of rectangular cross section indicates that glottis-interior boundary/shear layer vortex sources and the surface frictional source are of comparable importance; the influence of the potential flow source is about an order of magnitude smaller. © 2012 Acoustical Society of America

Source-sink interaction: a century old concept under the light of modern molecular systems biology.

PubMed

Chang, Tian-Gen; Zhu, Xin-Guang; Raines, Christine

2017-07-20

Many approaches to engineer source strength have been proposed to enhance crop yield potential. However, a well-co-ordinated source-sink relationship is required finally to realize the promised increase in crop yield potential in the farmer's field. Source-sink interaction has been intensively studied for decades, and a vast amount of knowledge about the interaction in different crops and under different environments has been accumulated. In this review, we first introduce the basic concepts of source, sink and their interactions, then summarize current understanding of how source and sink can be manipulated through both environmental control and genetic manipulations. We show that the source-sink interaction underlies the diverse responses of crops to the same perturbations and argue that development of a molecular systems model of source-sink interaction is required towards a rational manipulation of the source-sink relationship for increased yield. We finally discuss both bottom-up and top-down routes to develop such a model and emphasize that a community effort is needed for development of this model. © The Author 2017. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Differences among practitioners in patterns of preference for information sources in the adoption of new drugs.

PubMed

Peay, M Y; Peay, E R

1984-01-01

The major aim of this study was to identify coherent patterns in doctors' preferences for potential sources of information about new drugs and the characteristics of the doctors who display them. One hundred twenty-four general practitioners and specialists evaluated and reported their use of a number of potential sources. Overall, commercial sources were cited more often than professional ones for providing first information about a new drug, but the reverse was the case when the doctor was actively considering prescribing it. The primary professional sources received more favourable evaluation than any of the commercial sources, but results suggest that usage does not necessarily follow the doctor's opinion of a source. Relationships between reported use and evaluation reveal two coherent patterns of source preference: 'journal' and 'commercial'. The commercial pattern is particularly sharply defined, identifying a subset of doctors who can be designated justifiably as 'commercially-oriented'. Evaluation and use of particular sources varied with age and differed between specialists and general practitioners. Results indicate that differences in patterns of preference are systematically related to characteristics of the doctor in combination with the stage of the adoption process.

Wastewater treatment plant effluent as a source of microplastics: review of the fate, chemical interactions and potential risks to aquatic organisms.

PubMed

Ziajahromi, Shima; Neale, Peta A; Leusch, Frederic D L

2016-11-01

Wastewater treatment plant (WWTP) effluent has been identified as a potential source of microplastics in the aquatic environment. Microplastics have recently been detected in wastewater effluent in Western Europe, Russia and the USA. As there are only a handful of studies on microplastics in wastewater, it is difficult to accurately determine the contribution of wastewater effluent as a source of microplastics. However, even the small amounts of microplastics detected in wastewater effluent may be a remarkable source given the large volumes of wastewater treatment effluent discharged to the aquatic environment annually. Further, there is strong evidence that microplastics can interact with wastewater-associated contaminants, which has the potential to transport chemicals to aquatic organisms after exposure to contaminated microplastics. In this review we apply lessons learned from the literature on microplastics in the aquatic environment and knowledge on current wastewater treatment technologies, with the aim of identifying the research gaps in terms of (i) the fate of microplastics in WWTPs, (ii) the potential interaction of wastewater-based microplastics with trace organic contaminants and metals, and (iii) the risk for aquatic organisms.

The role of alprazolam for the treatment of panic disorder in Australia.

PubMed

Moylan, Steven; Giorlando, Francesco; Nordfjærn, Trond; Berk, Michael

2012-03-01

To investigate the potential impact of increasing prescription rates of alprazolam for the treatment of panic disorder (PD) in Australia through a review of efficacy, tolerability and adverse outcome literature. Data were sourced by a literature search using MEDLINE, Embase, PsycINFO and a manual search of scientific journals to identify relevant articles. Clinical practice guidelines from the American Psychiatric Association, National Institute of Clinical Excellence, Royal Australian and New Zealand College of Psychiatrists and World Federation of Societies of Biological Psychiatry were sourced. Prescription data were sourced from Australian governmental sources. Alprazolam has shown efficacy for control of PD symptoms, particularly in short-term controlled clinical trials, but is no longer recommended as a first-line pharmacological treatment due to concerns about the risks of developing tolerance, dependence and abuse potential. Almost no evidence is available comparing alprazolam to current first-line pharmacological treatment. Despite this, prescription rates are increasing. A number of potential issues including use in overdose and impact on car accidents are noted. conclusion: Although effective for PD symptoms in clinical trials, a number of potential issues may exist with use. Consideration of its future place in PD treatment in Australia may be warranted.

Potential for nutrient recovery and biogas production from blackwater, food waste and greywater in urban source control systems.

PubMed

Kjerstadius, H; Haghighatafshar, S; Davidsson, Å

2015-01-01

In the last decades, the focus on waste and wastewater treatment systems has shifted towards increased recovery of energy and nutrients. Separation of urban food waste (FW) and domestic wastewaters using source control systems could aid this increase; however, their effect on overall sustainability is unknown. To obtain indicators for sustainability assessments, five urban systems for collection, transport, treatment and nutrient recovery from blackwater, greywater and FW were investigated using data from implementations in Sweden or northern Europe. The systems were evaluated against their potential for biogas production and nutrient recovery by the use of mass balances for organic material, nutrients and metals over the system components. The resulting indicators are presented in units suitable for use in future sustainability studies or life-cycle assessment of urban waste and wastewater systems. The indicators show that source control systems have the potential to increase biogas production by more than 70% compared with a conventional system and give a high recovery of phosphorus and nitrogen as biofertilizer. The total potential increase in gross energy equivalence for source control systems was 20-100%; the greatest increase shown is for vacuum-based systems.

The Bolivian source rocks: Sub Andean Zone-Madre de Dios-Chaco

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moretti, I.; Montemurro, G.; Aguilera, E.

A complete study of source rocks has been carried out in the Bolivian foothills and foreland (Sub Andean Zone, Chaco and Madre de Dios) in order to quantify the petroleum potential of the area. Besides the classical mid-Devonian source rocks (Tequeje Formation in the north, Limoncito Formation in the center and Los Monos Formation in the south), others are important: the Tomachi Formation (late Devonian) in the north and the Copacabana Formation (Upper Carboniferous-lower Permian) in the northern Sub Andean Zone. Both show an excellent potential with S{sub 2} over 50 mg HC/g and average values higher than 10 mgmore » HC/g over few hundred meters. The Latest Cretaceous Flora Formation present locally a high potential but is very thin. Almost all the source rocks matured during the Neogene due to the subsidence in the Andean foreland and in the piggyback basins, and are thus involved on the current petroleum system. Silurian and Lower Paleozoic units also contain thick shale beds, but these source rocks were mature before the Jurassic in the south of the country. In the center, the Silurian is not nowadays overmature and may play an important role. The different zones are compared based on their Source Potential Index which indicates that the richest areas are the northern Sub Andean Zone and the Madre de Dios basin with SPI greater than 10 t/m{sup 2}. Since these two areas remain almost unexplored, these results allow us to be optimistic about the possibilities for future exploration.« less

Barium as a potential indicator of phosphorus in agricultural runoff.

PubMed

Ahlgren, Joakim; Djodjic, Faruk; Wallin, Mats

2012-01-01

In many catchments, anthropogenic input of contaminants, and in particular phosphorus (P), into surface water is a mixture of agricultural and sewage runoff. Knowledge about the relative contribution from each of these sources is vital for mitigation of major environmental problems such as eutrophication. In this study, we investigated whether the distribution of trace elements in surface waters can be used to trace the contamination source. Water from three groups of streams was investigated: streams influenced only by agricultural runoff, streams influenced mainly by sewage runoff, and reference streams. Samples were collected at different flow regimes and times of year and analyzed for 62 elements using ICP-MS. Our results show that there are significant differences between the anthropogenic sources affecting the streams in terms of total element composition and individual elements, indicating that the method has the potential to trace anthropogenic impact on surface waters. The elements that show significant differences between sources are strontium (p < 0.001), calcium (p < 0.004), potassium (p < 0.001), magnesium (p < 0.001), boron (p < 0.001), rhodium (p = 0.001), and barium (p < 0.001). According to this study, barium shows the greatest potential as a tracer for an individual source of anthropogenic input to surface waters. We observed a strong relationship between barium and total P in the investigated samples (R(2) = 0.78), which could potentially be used to apportion anthropogenic sources of P and thereby facilitate targeting of mitigation practices. Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.

Data Mashups: Potential Contribution to Decision Support on Climate Change and Health

PubMed Central

Fleming, Lora E.; Haines, Andy; Golding, Brian; Kessel, Anthony; Cichowska, Anna; Sabel, Clive E.; Depledge, Michael H.; Sarran, Christophe; Osborne, Nicholas J.; Whitmore, Ceri; Cocksedge, Nicola; Bloomfield, Daniel

2014-01-01

Linking environmental, socioeconomic and health datasets provides new insights into the potential associations between climate change and human health and wellbeing, and underpins the development of decision support tools that will promote resilience to climate change, and thus enable more effective adaptation. This paper outlines the challenges and opportunities presented by advances in data collection, storage, analysis, and access, particularly focusing on “data mashups”. These data mashups are integrations of different types and sources of data, frequently using open application programming interfaces and data sources, to produce enriched results that were not necessarily the original reason for assembling the raw source data. As an illustration of this potential, this paper describes a recently funded initiative to create such a facility in the UK for use in decision support around climate change and health, and provides examples of suitable sources of data and the purposes to which they can be directed, particularly for policy makers and public health decision makers. PMID:24499879

Data mashups: potential contribution to decision support on climate change and health.

PubMed

Fleming, Lora E; Haines, Andy; Golding, Brian; Kessel, Anthony; Cichowska, Anna; Sabel, Clive E; Depledge, Michael H; Sarran, Christophe; Osborne, Nicholas J; Whitmore, Ceri; Cocksedge, Nicola; Bloomfield, Daniel

2014-02-04

Linking environmental, socioeconomic and health datasets provides new insights into the potential associations between climate change and human health and wellbeing, and underpins the development of decision support tools that will promote resilience to climate change, and thus enable more effective adaptation. This paper outlines the challenges and opportunities presented by advances in data collection, storage, analysis, and access, particularly focusing on "data mashups". These data mashups are integrations of different types and sources of data, frequently using open application programming interfaces and data sources, to produce enriched results that were not necessarily the original reason for assembling the raw source data. As an illustration of this potential, this paper describes a recently funded initiative to create such a facility in the UK for use in decision support around climate change and health, and provides examples of suitable sources of data and the purposes to which they can be directed, particularly for policy makers and public health decision makers.

Characteristics of Ampel bamboo as a biomass energy source potential in Bali

NASA Astrophysics Data System (ADS)

Sucipta, M.; Putra Negara, D. N. K.; Tirta Nindhia, T. G.; Surata, I. W.

2017-05-01

Currently, non-renewable fossil energy dominates utilization of the world energy need for many applications. Efforts has been developed to find alternative renewable energy sources, due to fossil energy availability is diminishing. And one of renewable energy source is from biomass. The aim of this research is to determine characteristics of the Ampel bamboo (Bambusa vulgaris) as an energy potential of biomass. The Ampel bamboo’s characteristics possessed are evaluated based on its chemical composition; moisture, volatile, ash, and fixed carbon through proximate analysis; and also carbon, hydrogen and nitrogen content through ultimate analysis. From the Thermo-gravimetric analysis (TGA) indicates that Ampel bamboo contains of about 18.10% hemicelluloses, 47.75% cellulose and 18.86% lignin. While from the ultimate analysis results in the content of carbon, hydrogen, and Nitrogen of Ampel bamboo are 39.75%, 5.75% and 0% respectively. With such characteristics, it indicates that Ampel bamboo has an attractive potential as a renewable energy source.

Modeling of self-potential anomalies near vertical dikes.

USGS Publications Warehouse

Fitterman, D.V.

1983-01-01

The self-potential (SP) Green's function for an outcropping vertical dike is derived from solutions for the dc resistivity problem for the same geometry. The Green's functions are numerically integrated over rectangular source regions on the contacts between the dike and the surrounding material to obtain the SP anomaly. The analysis is valid for thermoelectrical source mechanisms. Two types of anomalies can be produced by this geometry. When the two source planes are polarized in opposite directions, a monopolar anomaly is produced. This corresponds to the thermoelectrical properties of the dike being in contrast with the surrounding material. When the thermoelectric coefficients change monotonically across the dike, a dipolar anomaly is produced. In either case positive and negative anomalies are possible, and the greatest variation in potential will occur in the most resistive regions. -Author

EMISSION CHARACTERIZATION OF STATIONARY NOX SOURCES: VOLUME 1. RESULTS

EPA Science Inventory

The report gives results of an inventory of gaseous, liquid, and solid effluents from stationary NOx sources, projected to the year 2000, and ranks them according to their potential for environmental hazard. It classifies sources according to their pollution formation characteris...

Event-Related Potential (ERP) Evidence for Varied Recollection during Source Monitoring

ERIC Educational Resources Information Center

Leynes, P. Andrew; Phillips, Michelle C.

2008-01-01

The source monitoring framework (SMF; M. K. Johnson, S. Hashtroudi, & D. S. Lindsay, 1993) posits that source monitoring can be supported by varying degrees of recollection. Source judgments were made for words heard at study (male or female voice) followed by remember/know (RK) judgments in order to assess differences in degrees of recollection…

Quantifying the source-sink balance and carbohydrate content in three tomato cultivars.

PubMed

Li, Tao; Heuvelink, Ep; Marcelis, Leo F M

2015-01-01

Supplementary lighting is frequently applied in the winter season for crop production in greenhouses. The effect of supplementary lighting on plant growth depends on the balance between assimilate production in source leaves and the overall capacity of the plants to use assimilates. This study aims at quantifying the source-sink balance and carbohydrate content of three tomato cultivars differing in fruit size, and to investigate to what extent the source/sink ratio correlates with the potential fruit size. Cultivars Komeet (large size), Capricia (medium size), and Sunstream (small size, cherry tomato) were grown from 16 August to 21 November, at similar crop management as in commercial practice. Supplementary lighting (High Pressure Sodium lamps, photosynthetic active radiation at 1 m below lamps was 162 μmol photons m(-2) s(-1); maximum 10 h per day depending on solar irradiance level) was applied from 19 September onward. Source strength was estimated from total plant growth rate using periodic destructive plant harvests in combination with the crop growth model TOMSIM. Sink strength was estimated from potential fruit growth rate which was determined from non-destructively measuring the fruit growth rate at non-limiting assimilate supply, growing only one fruit on each truss. Carbohydrate content in leaves and stems were periodically determined. During the early growth stage, 'Komeet' and 'Capricia' showed sink limitation and 'Sunstream' was close to sink limitation. During this stage reproductive organs had hardly formed or were still small and natural irradiance was high (early September) compared to winter months. Subsequently, during the fully fruiting stage all three cultivars were strongly source-limited as indicated by the low source/sink ratio (average source/sink ratio from 50 days after planting onward was 0.17, 0.22, and 0.33 for 'Komeet,' 'Capricia,' and 'Sunstream,' respectively). This was further confirmed by the fact that pruning half of the fruits hardly influenced net leaf photosynthesis rates. Carbohydrate content in leaves and stems increased linearly with the source/sink ratio. We conclude that during the early growth stage under high irradiance, tomato plants are sink-limited and that the level of sink limitation differs between cultivars but it is not correlated with their potential fruit size. During the fully fruiting stage tomato plants are source-limited and the extent of source limitation of a cultivar is positively correlated with its potential fruit size.

Geology and hydrocarbon potential of the Dead Sea Rift Basins of Israel and Jordan

USGS Publications Warehouse

Coleman, James; ten Brink, Uri S.

2016-01-01

Geochemical analyses indicate that the source of all oils, asphalts, and tars recovered in the Lake Lisan basin is the Ghareb Formation. Geothermal gradients along the Dead Sea fault zone vary from basin to basin. Syn-wrench potential reservoir rocks are highly porous and permeable, whereas pre-wrench strata commonly exhibit lower porosity and permeability. Biogenic gas has been produced from Pleistocene reservoirs. Potential sealing intervals may be present in Neogene evaporites and tight lacustrine limestones and shales. Simple structural traps are not evident; however, subsalt traps may exist. Unconventional source rock reservoir potential has not been tested.

Tsunami hazard potential for the equatorial southwestern Pacific atolls of Tokelau from scenario-based simulations

NASA Astrophysics Data System (ADS)

Orpin, Alan R.; Rickard, Graham J.; Gerring, Peter K.; Lamarche, Geoffroy

2016-05-01

Devastating tsunami over the last decade have significantly heightened awareness of the potential consequences and vulnerability of low-lying Pacific islands and coastal regions. Our appraisal of the potential tsunami hazard for the atolls of the Tokelau Islands is based on a tsunami source-propagation-inundation model using Gerris Flow Solver, adapted from the companion study by Lamarche et al. (2015) for the islands of Wallis and Futuna. We assess whether there is potential for tsunami flooding on any of the village islets from a selection of 14 earthquake-source experiments. These earthquake sources are primarily based on the largest Pacific earthquakes of Mw ≥ 8.1 since 1950 and other large credible sources of tsunami that may impact Tokelau. Earthquake-source location and moment magnitude are related to tsunami-wave amplitudes and tsunami flood depths simulated for each of the three atolls of Tokelau. This approach yields instructive results for a community advisory but is not intended to be fully deterministic. Rather, the underlying aim is to identify credible sources that present the greatest potential to trigger an emergency response. Results from our modelling show that wave fields are channelled by the bathymetry of the Pacific basin in such a way that the swathes of the highest waves sweep immediately northeast of the Tokelau Islands. Our limited simulations suggest that trans-Pacific tsunami from distant earthquake sources to the north of Tokelau pose the most significant inundation threat. In particular, our assumed worst-case scenario for the Kuril Trench generated maximum modelled-wave amplitudes in excess of 1 m, which may last a few hours and include several wave trains. Other sources can impact specific sectors of the atolls, particularly distant earthquakes from Chile and Peru, and regional earthquake sources to the south. Flooding is dependent on the wave orientation and direct alignment to the incoming tsunami. Our "worst-case" tsunami simulations of the Tokelau Islands suggest that dry areas remain around the villages, which are typically built on a high islet. Consistent with the oral history of little or no perceived tsunami threat, simulations from the recent Tohoku and Chile earthquake sources suggest only limited flooding around low-lying islets of the atoll. Where potential tsunami flooding is inferred from the modelling, recommended minimum evacuation heights above local sea level are compiled, with particular attention paid to variations in tsunami flood depth around the atolls, subdivided into directional quadrants around each atoll. However, complex wave behaviours around the atolls, islets, tidal channels and within the lagoons are also observed in our simulations. Wave amplitudes within the lagoons may exceed 50 cm, increasing any inundation and potential hazards on the inner shoreline of the atolls, which in turn may influence evacuation strategies. Our study shows that indicative simulation studies can be achieved even with only basic field information. In part, this is due to the spatially and vertically limited topography of the atoll, short reef flat and steep seaward bathymetry, and the simple depth profile of the lagoon bathymetry.

Laser technologies for ultrasensitive groundwater dating using long-lived isotopes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Backus, Sterling

In this phase I work, we propose to construct and demonstrate a 103 nm laser based on resonantly enhanced and phase matched fifth harmonic generation in hollow waveguides driven by a high power, low cost and compact ultrafast fiber laser. (Figure 4) This VUV laser source can potentially produce >100 milliwatts of VUV light at 103 nm with pulse repetition-rates of 100 kHz to 100 MHz, ideal for the above-mentioned applications. This technology is state-of-the-art and potentially compact, fieldable, low-cost, and of broad interest for a variety of science and technology applications. Laser-based VUV sources in the past have exhibitedmore » low repetition rate, low efficiency, low beam quality, and are based on expensive laser sources. Our approch is to combine ultrafast fiber laser drive technology, ultrafast pulses, and our proven waveguide technology, to create a high repetition rate, high average power VUV source for producing high yield metastable Krypton. At KMLabs we have been offering EUV light sources employing the high harmonic generation (HHG) process driven by high-power femtosecond lasers for >5 years now. Recently, we have developed much smaller scale (briefcase size), but still high average power femtosecond fiber laser sources to supply other markets, and create new ones. By combining these new laser sources with our patented waveguide frequency upconversion technology, we expect to be able to obtain >20mW average power initially, with potentially much higher powers depending on wavelength, in an affordable VUV product. For comparison, our current EUV light sources based on ti:sapphire generate an average power of ~5 µW (albeit at shorter 29 nm wavelength), and we are aware of one other supplier that has developed a VUV (112 nm) light source with ~10-20 µW power.« less

Using cGPS to estimate the magma budget for Soufrière Hills volcano, Montserrat, West Indies

NASA Astrophysics Data System (ADS)

Collinson, Amy; Neuberg, Jurgen; Pascal, Karen

2017-04-01

For over 20 years, Soufrière Hills Volcano, Montserrat has been in a state of volcanic unrest. Intermittent periods of dome building have been punctuated by explosive eruptions and dome collapse events, endangering the lives of the inhabitants of the island. The last episode of active magma extrusion was in February 2010, and the last explosive event (ash venting) in March 2012. Despite a lack of recent eruptive activity, the volcano continues to emit significant volumes of SO2 and shows an ongoing trend of island inflation as indicated by cGPS. Through the aid of three-dimensional numerical modelling, using a finite element method, we model the cGPS data to explore the potential sources of the ongoing island deformation. We consider both magmatic (dykes and chambers) and tectonic sources which result in entirely different interpretations: Whilst a magmatic source suggests the possibility for further eruption, a tectonic source may indicate cessation of volcanic activity. We investigate the effects that different sources (shapes, characters and depths) have on the surface displacement. We demonstrate that whilst a tectonic contribution cannot be completely discounted, the dominant source is magmatic. Consequently, we define a best-fit model which we use to assess the source volume change, and therefore, the potential current magma budget. Based on the similarity in the relative displacement between the cGPS stations at every episode of the eruption, we assume that the displacement for all Phases and Pauses can be explained by the same basic source. Therefore, we interpret the cGPS data with our source model for all the preceding Pauses and Phases to estimate the magma budget feeding the entire eruption. Subsequently, we derive important insights into the potential future eruptive behaviour of the volcano.

Influence of tissue resistivities on neuromagnetic fields and electric potentials studied with a finite element model of the head.

PubMed

Haueisen, J; Ramon, C; Eiselt, M; Brauer, H; Nowak, H

1997-08-01

Modeling in magnetoencephalography (MEG) and electroencephalography (EEG) requires knowledge of the in vivo tissue resistivities of the head. The aim of this paper is to examine the influence of tissue resistivity changes on the neuromagnetic field and the electric scalp potential. A high-resolution finite element method (FEM) model (452,162 elements, 2-mm resolution) of the human head with 13 different tissue types is employed for this purpose. Our main finding was that the magnetic fields are sensitive to changes in the tissue resistivity in the vicinity of the source. In comparison, the electric surface potentials are sensitive to changes in the tissue resistivity in the vicinity of the source and in the vicinity of the position of the electrodes. The magnitude (strength) of magnetic fields and electric surface potentials is strongly influenced by tissue resistivity changes, while the topography is not as strongly influenced. Therefore, an accurate modeling of magnetic field and electric potential strength requires accurate knowledge of tissue resistivities, while for source localization procedures this knowledge might not be a necessity.

Equivalent magnetic vector potential model for low-frequency magnetic exposure assessment

NASA Astrophysics Data System (ADS)

Diao, Y. L.; Sun, W. N.; He, Y. Q.; Leung, S. W.; Siu, Y. M.

2017-10-01

In this paper, a novel source model based on a magnetic vector potential for the assessment of induced electric field strength in a human body exposed to the low-frequency (LF) magnetic field of an electrical appliance is presented. The construction of the vector potential model requires only a single-component magnetic field to be measured close to the appliance under test, hence relieving considerable practical measurement effort—the radial basis functions (RBFs) are adopted for the interpolation of discrete measurements; the magnetic vector potential model can then be directly constructed by summing a set of simple algebraic functions of RBF parameters. The vector potentials are then incorporated into numerical calculations as the equivalent source for evaluations of the induced electric field in the human body model. The accuracy and effectiveness of the proposed model are demonstrated by comparing the induced electric field in a human model to that of the full-wave simulation. This study presents a simple and effective approach for modelling the LF magnetic source. The result of this study could simplify the compliance test procedure for assessing an electrical appliance regarding LF magnetic exposure.

Equivalent magnetic vector potential model for low-frequency magnetic exposure assessment.

PubMed

Diao, Y L; Sun, W N; He, Y Q; Leung, S W; Siu, Y M

2017-09-21

In this paper, a novel source model based on a magnetic vector potential for the assessment of induced electric field strength in a human body exposed to the low-frequency (LF) magnetic field of an electrical appliance is presented. The construction of the vector potential model requires only a single-component magnetic field to be measured close to the appliance under test, hence relieving considerable practical measurement effort-the radial basis functions (RBFs) are adopted for the interpolation of discrete measurements; the magnetic vector potential model can then be directly constructed by summing a set of simple algebraic functions of RBF parameters. The vector potentials are then incorporated into numerical calculations as the equivalent source for evaluations of the induced electric field in the human body model. The accuracy and effectiveness of the proposed model are demonstrated by comparing the induced electric field in a human model to that of the full-wave simulation. This study presents a simple and effective approach for modelling the LF magnetic source. The result of this study could simplify the compliance test procedure for assessing an electrical appliance regarding LF magnetic exposure.

Silicosis surveillance in New Jersey: targeting workplaces using occupational disease and exposure surveillance data.

PubMed

Valiante, D J; Richards, T B; Kinsley, K B

1992-01-01

To identify workplaces in New Jersey with potential for silica exposure, the New Jersey Department of Health compared four-digit Standard Industrial Classifications (SICs) identified by three different data sources: the National Occupational Exposure Survey (NOES), a new Jersey silicosis case registry, and regulatory agency compliance inspections in New Jersey. In total, the three data sources identified 204 SICs in New Jersey with potential for silica exposure. Forty-five percent of these SICs were identified by NOES only, 16% by registry cases only, 6% by compliance inspections only, and 33% by two or more sources. Since different surveillance sources implicate different SICs, this type of analysis is a useful first step in planning programs for prevention of silicosis.

Time-resolved structural studies at synchrotrons and X-ray free electron lasers: opportunities and challenges

PubMed Central

Neutze, Richard; Moffat, Keith

2012-01-01

X-ray free electron lasers (XFELs) are potentially revolutionary X-ray sources because of their very short pulse duration, extreme peak brilliance and high spatial coherence, features that distinguish them from today’s synchrotron sources. We review recent time-resolved Laue diffraction and time-resolved wide angle X-ray scattering (WAXS) studies at synchrotron sources, and initial static studies at XFELs. XFELs have the potential to transform the field of time-resolved structural biology, yet many challenges arise in devising and adapting hardware, experimental design and data analysis strategies to exploit their unusual properties. Despite these challenges, we are confident that XFEL sources are poised to shed new light on ultrafast protein reaction dynamics. PMID:23021004

Toxicological benchmarks for screening potential contaminants of concern for effects on aquatic biota: 1996 revision

DOE Office of Scientific and Technical Information (OSTI.GOV)

Suter, G.W. II; Tsao, C.L.

1996-06-01

This report presents potential screening benchmarks for protection of aquatic life form contaminants in water. Because there is no guidance for screening for benchmarks, a set of alternative benchmarks is presented herein. This report presents the alternative benchmarks for chemicals that have been detected on the Oak Ridge Reservation. It also presents the data used to calculate the benchmarks and the sources of the data. It compares the benchmarks and discusses their relative conservatism and utility. Also included is the updates of benchmark values where appropriate, new benchmark values, secondary sources are replaced by primary sources, and a more completemore » documentation of the sources and derivation of all values are presented.« less

A Global Sensitivity Analysis Method on Maximum Tsunami Wave Heights to Potential Seismic Source Parameters

NASA Astrophysics Data System (ADS)

Ren, Luchuan

2015-04-01

A Global Sensitivity Analysis Method on Maximum Tsunami Wave Heights to Potential Seismic Source Parameters Luchuan Ren, Jianwei Tian, Mingli Hong Institute of Disaster Prevention, Sanhe, Heibei Province, 065201, P.R. China It is obvious that the uncertainties of the maximum tsunami wave heights in offshore area are partly from uncertainties of the potential seismic tsunami source parameters. A global sensitivity analysis method on the maximum tsunami wave heights to the potential seismic source parameters is put forward in this paper. The tsunami wave heights are calculated by COMCOT ( the Cornell Multi-grid Coupled Tsunami Model), on the assumption that an earthquake with magnitude MW8.0 occurred at the northern fault segment along the Manila Trench and triggered a tsunami in the South China Sea. We select the simulated results of maximum tsunami wave heights at specific sites in offshore area to verify the validity of the method proposed in this paper. For ranking importance order of the uncertainties of potential seismic source parameters (the earthquake's magnitude, the focal depth, the strike angle, dip angle and slip angle etc..) in generating uncertainties of the maximum tsunami wave heights, we chose Morris method to analyze the sensitivity of the maximum tsunami wave heights to the aforementioned parameters, and give several qualitative descriptions of nonlinear or linear effects of them on the maximum tsunami wave heights. We quantitatively analyze the sensitivity of the maximum tsunami wave heights to these parameters and the interaction effects among these parameters on the maximum tsunami wave heights by means of the extended FAST method afterward. The results shows that the maximum tsunami wave heights are very sensitive to the earthquake magnitude, followed successively by the epicenter location, the strike angle and dip angle, the interactions effect between the sensitive parameters are very obvious at specific site in offshore area, and there exist differences in importance order in generating uncertainties of the maximum tsunami wave heights for same group parameters at different specific sites in offshore area. These results are helpful to deeply understand the relationship between the tsunami wave heights and the seismic tsunami source parameters. Keywords: Global sensitivity analysis; Tsunami wave height; Potential seismic tsunami source parameter; Morris method; Extended FAST method

PMF and PSCF based source apportionment of PM2.5 at a regional background site in North China

NASA Astrophysics Data System (ADS)

Zong, Zheng; Wang, Xiaoping; Tian, Chongguo; Chen, Yingjun; Fu, Shanfei; Qu, Lin; Ji, Ling; Li, Jun; Zhang, Gan

2018-05-01

To apportion regional PM2.5 (atmospheric particles with aerodynamic diameter < 2.5 μm) source types and their geographic pattern in North China, 120 daily PM2.5 samples on Beihuangcheng Island (BH, a regional background site in North China) were collected from August 20th, 2014 to September 15th, 2015 showing one-year period. After the chemical analyses on carbonaceous species, water-soluble ions and inorganic elements, various approaches, such as Mann-Kendall test, chemical mass closure, ISORROPIA II model, Positive Matrix Factorization (PMF) linked with Potential Source Contribution Function (PSCF), were used to explore the PM2.5 speciation, sources, and source regions. Consequently, distinct seasonal variations of PM2.5 and its main species were found and could be explained by varying emission source characteristics. Based on PMF model, seven source factors for PM2.5 were identified, which were coal combustion + biomass burning, vehicle emission, mineral dust, ship emission, sea salt, industry source, refined chrome industry with the contribution of 48.21%, 30.33%, 7.24%, 6.63%, 3.51%, 3.2%, and 0.88%, respectively. In addition, PSCF analysis using the daily contribution of each factor from PMF result suggested that Shandong peninsula and Hebei province were identified as the high potential region for coal combustion + biomass burning; Beijing-Tianjin-Hebei (BTH) region was the main source region for industry source; Bohai Sea and East China Sea were found to be of high source potential for ship emission; Geographical region located northwest of BH Island was possessed of high probability for sea salt; Mineral dust presumably came from the region of Mongolia; Refined chrome industry mostly came from Liaoning, Jilin province; The vehicle emission was primarily of BTH region origin, centring on metropolises, such as Beijing and Tianjin. These results provided precious implications for PM2.5 control strategies in North China.

Chemical and biological tracers to determine groundwater flow in karstic aquifer, Yucatan Peninsula

NASA Astrophysics Data System (ADS)

Lenczewski, M.; Leal-Bautista, R. M.; McLain, J. E.

2013-05-01

Little is known about the extent of pollution in groundwater in the Yucatan Peninsula; however current population growth, both from international tourism and Mexican nationals increases the potential for wastewater release of a vast array of contaminants including personal care products, pharmaceuticals (Rx), and pathogenic microorganisms. Pathogens and Rx in groundwater can persist and can be particularly acute in this region where high permeability of the karst bedrock and the lack of top soil permit the rapid transport of contaminants into groundwater aquifers. The objective of this research is to develop and utilize novel biological and chemical source tracking methods to distinguish between different sources of anthropogenic pollution in degraded groundwater. Although several methods have been used successfully to track fecal contamination sources in small scale studies, little is known about their spatial limitations, as source tracking studies rarely include sample collection over a wide geographical area and with different sources of water. In addition, although source tracking methods to distinguish human from animal fecal contamination are widely available, this work has developed source tracking distinguish between separate human populations is highly unique. To achieve this objective, we collected water samples from a series of drinking wells, cenotes (sinkholes), wastewater treatment plants, and injection wells across the Yucatan Peninsula and examine potential source tracers within the collected water samples. The result suggests that groundwater sources impacted by tourist vs. local populations contain different chemical stressors. This work has developed a more detailed understanding of the presence and persistence of personal care products, pharmaceuticals, and fecal indicators in a karstic system; such understanding will be a vital component for the protection Mexican groundwater and human health. Quantification of different pollution sources within groundwater samples identified point sources of pollution, identify potential remediation strategies, and contribute to an improved understanding of the environmental impact of tourism and tourism-generated waste products on this groundwater-dependent ecosystem.

DETERMINATION OF FERRITIN AND HEMOSIDERIN IRON IN PATIENTS WITH NORMAL IRON STORES AND IRON OVERLOAD BY SERUM FERRITIN KINETICS

PubMed Central

SAITO, HIROSHI; TOMITA, AKIHIRO; OHASHI, HARUHIKO; MAEDA, HIDEAKI; HAYASHI, HISAO; NAOE, TOMOKI

2012-01-01

ABSTRACT We attempted to clarify the storage iron metabolism from the change in the serum ferritin level. We assumed that the nonlinear decrease in serum ferritin was caused by serum ferritin increase in iron mobilization. Under this assumption, we determined both ferritin and hemosiderin iron levels by computer-assisted simulation of the row of decreasing assay-dots of serum ferritin in 11 patients with normal iron stores free of both iron deficiency and iron overload; chronic hepatitis C (CHC) and iron deficiency anemia after treatment, and 11 patients with iron overload; hereditary hemochromatosis (HH) and transfusion-dependent anemias (TD). We determined the iron removal rates of 20 and 17 mg/day by administering mean doses of deferasirox at 631 and 616 mg/day in 2 TD during the period of balance of iron addition and removal as indicated by the serum ferritin returned to the previous level. The ferritin-per-hemosiderin ratio was almost the same in both HH and CHC. This matched the localized hepatic hemosiderin deposition in CHC with normal iron stores. We detected the ferritin increased by utilizing the hemosiderin iron in iron removal and the ferritin reduced by transforming ferritin into hemosiderin in iron additions. The iron storing capacity of hemosiderin was limitless, while that of ferritin was suppressed when ferritin iron exceeded around 5 grams. We confirmed the pathway of iron from hemosiderin to ferritin in iron mobilization, and that from ferritin to hemosiderin in iron deposition. Thus, serum ferritin kinetics enabled us to be the first to clinically clarify storage iron metabolism. PMID:22515110

Assessing the Relative Contributions of Active Ankle and Knee Assistance to the Walking Mechanics of Transfemoral Amputees Using a Powered Prosthesis

PubMed Central

Simon, Ann M.; Hargrove, Levi J.

2016-01-01

Powered knee-ankle prostheses are capable of providing net-positive mechanical energy to amputees. Yet, there are limitless ways to deliver this energy throughout the gait cycle. It remains largely unknown how different combinations of active knee and ankle assistance affect the walking mechanics of transfemoral amputees. This study assessed the relative contributions of stance phase knee swing initiation, increasing ankle stiffness and powered plantarflexion as three unilateral transfemoral amputees walked overground at their self-selected walking speed. Five combinations of knee and ankle conditions were evaluated regarding the kinematics and kinetics of the amputated and intact legs using repeated measures analyses of variance. We found eliminating active knee swing initiation or powered plantarflexion was linked to increased compensations of the ipsilateral hip joint during the subsequent swing phase. The elimination of knee swing initiation or powered plantarflexion also led to reduced braking ground reaction forces of the amputated and intact legs, and influenced both sagittal and frontal plane loading of the intact knee joint. Gradually increasing prosthetic ankle stiffness influenced the shape of the prosthetic ankle plantarflexion moment, more closely mirroring the intact ankle moment. Increasing ankle stiffness also corresponded to increased prosthetic ankle power generation (despite a similar maximum stiffness value across conditions) and increased braking ground reaction forces of the amputated leg. These findings further our understanding of how to deliver assistance with powered knee-ankle prostheses and the compensations that occur when specific aspects of assistance are added/removed. PMID:26807889

Space Shuttle Projects

NASA Image and Video Library

1990-07-08

The STS-40 patch makes a contemporary statement focusing on human beings living and working in space. Against a background of the universe, seven silver stars, interspersed about the orbital path of Columbia, represent the seven crew members. The orbiter's flight path forms a double-helix, designed to represent the DNA molecule common to all living creatures. In the words of a crew spokesman, ...(the helix) affirms the ceaseless expansion of human life and American involvement in space while simultaneously emphasizing the medical and biological studies to which this flight is dedicated. Above Columbia, the phrase Spacelab Life Sciences 1 defines both the Shuttle mission and its payload. Leonardo Da Vinci's Vitruvian man, silhouetted against the blue darkness of the heavens, is in the upper center portion of the patch. With one foot on Earth and arms extended to touch Shuttle's orbit, the crew feels, he serves as a powerful embodiment of the extension of human inquiry from the boundaries of Earth to the limitless laboratory of space. Sturdily poised amid the stars, he serves to link scentists on Earth to the scientists in space asserting the harmony of efforts which produce meaningful scientific spaceflight missions. A brilliant red and yellow Earth limb (center) links Earth to space as it radiates from a native American symbol for the sun. At the frontier of space, the traditional symbol for the sun vividly links America's past to America's future, the crew states. Beneath the orbiting Shuttle, darkness of night rests peacefully over the United States. Drawn by artist Sean Collins, the STS 40 Space Shuttle patch was designed by the crewmembers for the flight.

On the dynamics of viscous masonry beams

NASA Astrophysics Data System (ADS)

Lucchesi, M.; Pintucchi, B.; Šilhavý, M.; Zani, N.

2015-05-01

In this paper, we consider the longitudinal and transversal vibrations of the masonry beams and arches. The basic motivation is the seismic vulnerability analysis of masonry structures that can be modeled as monodimensional elements. The Euler-Bernoulli hypothesis is employed for the system of forces in the beam. The axial force and the bending moment are assumed to consist of the elastic and viscous parts. The elastic part is described by the no-tension material, i.e., the material with no resistance to tension and which accounts for the cases of limitless, as well as bounded compressive strength. The adaptation of this material to beams has been developed in Orlandi (Analisi non lineare di strutture ad arco in muratura. Thesis, 1999) and Zani (Eur J Mech A/Solids 23:467-484, 2004). The viscous part amounts to the Kelvin-Voigt damping depending linearly on the time derivatives of the linearized strain and curvature. The dynamical equations are formulated, and a mathematical analysis of them is presented. Specifically, following Gajewski et al. (Nichtlineare Operatorgleichungen und Operatordifferentialgleichungen. Akademie-Verlag, Berlin, 1974), the theorems of existence, uniqueness and regularity of the solution of the dynamical equations are recapitulated and specialized for our purposes, to support the numerical analysis applied previously in Lucchesi and Pintucchi (Eur J Mech A/Solids 26:88-105, 2007 ). As usual, for that the Galerkin method has been used. As an illustration, two numerical examples (slender masonry tower and masonry arch) are presented in this paper with the applied forces corresponding to the acceleration in the earthquake in Emilia Romagna in May 29, 2012.

The imaginative mind.

PubMed

Abraham, Anna

2016-11-01

The astounding capacity for the human imagination to be engaged across a wide range of contexts is limitless and fundamental to our day-to-day experiences. Although processes of imagination are central to human psychological function, they rarely occupy center stage in academic discourse or empirical study within psychological and neuroscientific realms. The aim of this paper is to tackle this imbalance by drawing together the multitudinous facets of imagination within a common framework. The processes fall into one of five categories depending on whether they are characterized as involving perceptual/motor related mental imagery, intentionality or recollective processing, novel combinatorial or generative processing, exceptional phenomenology in the aesthetic response, or altered psychological states which range from commonplace to dysfunctional. These proposed categories are defined on the basis of theoretical ideas from philosophy as well as empirical evidence from neuroscience. By synthesizing the findings across these domains of imagination, this novel five-part or quinquepartite classification of the human imagination aids in systematizing, and thereby abets, our understanding of the workings and neural foundations of the human imagination. It would serve as a blueprint to direct further advances in the field of imagination while also promoting crosstalk with reference to stimulus-oriented facets of information processing. A biologically and ecologically valid psychology is one that seeks to explain fundamental aspects of human nature. Given the ubiquitous nature of the imaginative operations in our daily lives, there can be little doubt that these quintessential aspects of the mind should be central to the discussion. Hum Brain Mapp 37:4197-4211, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

On the Modeling and Management of Cloud Data Analytics

NASA Astrophysics Data System (ADS)

Castillo, Claris; Tantawi, Asser; Steinder, Malgorzata; Pacifici, Giovanni

A new era is dawning where vast amount of data is subjected to intensive analysis in a cloud computing environment. Over the years, data about a myriad of things, ranging from user clicks to galaxies, have been accumulated, and continue to be collected, on storage media. The increasing availability of such data, along with the abundant supply of compute power and the urge to create useful knowledge, gave rise to a new data analytics paradigm in which data is subjected to intensive analysis, and additional data is created in the process. Meanwhile, a new cloud computing environment has emerged where seemingly limitless compute and storage resources are being provided to host computation and data for multiple users through virtualization technologies. Such a cloud environment is becoming the home for data analytics. Consequently, providing good performance at run-time to data analytics workload is an important issue for cloud management. In this paper, we provide an overview of the data analytics and cloud environment landscapes, and investigate the performance management issues related to running data analytics in the cloud. In particular, we focus on topics such as workload characterization, profiling analytics applications and their pattern of data usage, cloud resource allocation, placement of computation and data and their dynamic migration in the cloud, and performance prediction. In solving such management problems one relies on various run-time analytic models. We discuss approaches for modeling and optimizing the dynamic data analytics workload in the cloud environment. All along, we use the Map-Reduce paradigm as an illustration of data analytics.

In vitro autoradiographic localization of angiotensin-converting enzyme in sarcoid lymph nodes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allen, R.K.; Chai, S.Y.; Dunbar, M.S.

1986-09-01

Angiotensin-converting enzyme (ACE) was localized in sarcoid lymph nodes by an in vitro autoradiographic technique using a synthetic ACE inhibitor of high affinity, /sup 125/I-labelled 351A. The lymph nodes were from seven patients with active sarcoidosis who underwent mediastinoscopy and from six control subjects who had nodes resected at either mediastinoscopy or laparotomy. Angiotensin-converting enzyme was localized in the epithelioid cells of sarcoid granulomata in markedly increased amounts compared with control nodes, where it was restricted to vessels and some histiocytes. In sarcoid lymph nodes, there was little ACE present in lymphocytes or fibrous tissue. Sarcoid nodes with considerable fibrosismore » had much less intense ACE activity than the nonfibrotic nodes. The specific activity of ACE measured by an enzymatic assay in both the control and sarcoid lymph nodes closely reflected the ACE activity demonstrated by autoradiography. Sarcoid lymph nodes with fibrosis had an ACE specific activity of half that of nonfibrotic nodes (p less than 0.05). There was a 15-fold increase in specific ACE activity in sarcoid nodes (p less than 0.05) compared to normal. Serum ACE was significantly higher in those sarcoid patients whose lymph nodes were not fibrosed compared with those with fibrosis (p less than 0.01). This technique offers many advantages over the use of polyclonal antibodies. The 351A is a highly specific ACE inhibitor, chemically defined and in limitless supply. This method enables the quantitation of results, and autoradiographs may be stored indefinitely for later comparison.« less

STS-40 Mission Insignia

NASA Technical Reports Server (NTRS)

1990-01-01

The STS-40 patch makes a contemporary statement focusing on human beings living and working in space. Against a background of the universe, seven silver stars, interspersed about the orbital path of Columbia, represent the seven crew members. The orbiter's flight path forms a double-helix, designed to represent the DNA molecule common to all living creatures. In the words of a crew spokesman, ...(the helix) affirms the ceaseless expansion of human life and American involvement in space while simultaneously emphasizing the medical and biological studies to which this flight is dedicated. Above Columbia, the phrase Spacelab Life Sciences 1 defines both the Shuttle mission and its payload. Leonardo Da Vinci's Vitruvian man, silhouetted against the blue darkness of the heavens, is in the upper center portion of the patch. With one foot on Earth and arms extended to touch Shuttle's orbit, the crew feels, he serves as a powerful embodiment of the extension of human inquiry from the boundaries of Earth to the limitless laboratory of space. Sturdily poised amid the stars, he serves to link scentists on Earth to the scientists in space asserting the harmony of efforts which produce meaningful scientific spaceflight missions. A brilliant red and yellow Earth limb (center) links Earth to space as it radiates from a native American symbol for the sun. At the frontier of space, the traditional symbol for the sun vividly links America's past to America's future, the crew states. Beneath the orbiting Shuttle, darkness of night rests peacefully over the United States. Drawn by artist Sean Collins, the STS 40 Space Shuttle patch was designed by the crewmembers for the flight.

Microsporidia and 'the art of living together'.

PubMed

Vávra, Jiří; Lukeš, Julius

2013-01-01

Parasitism, aptly defined as one of the 'living-together' strategies (Trager, 1986), presents a dynamic system in which the parasite and its host are under evolutionary pressure to evolve new and specific adaptations, thus enabling the coexistence of the two closely interacting partners. Microsporidia are very frequently encountered obligatory intracellular protistan parasites that can infect both animals and some protists and are a consummate example of various aspects of the 'living-together' strategy. Microsporidia, relatives of fungi in the superkingdom Opisthokonta, belong to the relatively small group of parasites for which the host cell cytoplasm is the site of both reproduction and maturation. The structural and physiological reduction of their vegetative stage, together with the manipulation of host cell physiology, enables microsporidia to live in the cytosolic environment for most of their life cycle in a way resembling endocytobionts. The ability to form structurally complex spores and the invention and assembly of a unique injection mechanism enable microsporidia to disperse within host tissues and between host organisms, resulting in long-lasting infections. Microsporidia have adapted their genomes to the intracellular way of life, evolved strategies how to obtain nutrients directly from the host and how to manipulate not only the infected cells, but also the hosts themselves. The enormous variability of host organisms and their tissues provide microsporidian parasites a virtually limitless terrain for diversification and ecological expansion. This review attempts to present a general overview of microsporidia, emphasising some less known and/or more recently discovered facets of their biology. Copyright © 2013 Elsevier Ltd. All rights reserved.

Music facilitate the neurogenesis, regeneration and repair of neurons.

PubMed

Fukui, Hajime; Toyoshima, Kumiko

2008-11-01

Experience has shown that therapy using music for therapeutic purposes has certain effects on neuropsychiatric disorders (both functional and organic disorders). However, the mechanisms of action underlying music therapy remain unknown, and scientific clarification has not advanced. While that study disproved the Mozart effect, the effects of music on the human body and mind were not disproved. In fact, more scientific studies on music have been conducted in recent years, mainly in the field of neuroscience, and the level of interest among researchers is increasing. The results of past studies have clarified that music influences and affects cranial nerves in humans from fetus to adult. The effects of music at a cellular level have not been clarified, and the mechanisms of action for the effects of music on the brain have not been elucidated. We propose that listening to music facilitates the neurogenesis, the regeneration and repair of cerebral nerves by adjusting the secretion of steroid hormones, ultimately leading to cerebral plasticity. Music affects levels of such steroids as cortisol (C), testosterone (T) and estrogen (E), and we believe that music also affects the receptor genes related to these substances, and related proteins. In the prevention of Alzheimer's disease and dementia, hormone replacement therapy has been shown to be effective, but at the same time, side effects have been documented, and the clinical application of hormone replacement therapy is facing a serious challenge. Conversely, music is noninvasive, and its existence is universal and mundane. Thus, if music can be used in medical care, the application of such a safe and inexpensive therapeutic option is limitless.

Wall charging of a helicon antenna wrapped plasma filled dielectric tube

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barada, Kshitish K., E-mail: kbarada@physics.ucla.edu; Chattopadhyay, P. K., E-mail: pkchatto@ipr.res.in; Ghosh, J.

2015-01-15

Dielectric wall charging of a cylindrical glass wall surrounded by a helicon antenna of 18 cm length is measured in a linear helicon plasma device with a diverging magnetic field. The ions because of their lesser mobility do not respond to the high frequency electric field and the electrons charge the wall to a negative DC potential also known as the DC self-bias. The wall potential in this device is characterized for different neutral pressure, magnetic field, and radio frequency (RF) power. Axial variation of wall potential shows higher self-bias potentials near the antenna rings. Ion magnetization in the source chambermore » increases both wall charging and plasma potential of the source due to confinement.« less

Diffraction and Transmission Synchrotron Imaging at the German Light Source ANKA--Potential Industrial Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rack, Alexander; Weitkamp, Timm; European Synchrotron Radiation Facility, BP 220, F-38043 Grenoble Cedex

2009-03-10

Diffraction and transmission synchrotron imaging methods have proven to be highly suitable for investigations in materials research and non-destructive evaluation. The high flux and spatial coherence of X-rays from modern synchrotron light sources allows one to work using high resolution and different contrast modalities. This article gives a short overview of different transmission and diffraction imaging methods with high potential for industrial applications, now available for commercial access via the German light source ANKA (Forschungszentrum Karlsruhe) and its new department ANKA Commercial Service (ANKA COS, http://www.anka-cos.de)

Application of enteric viruses for fecal pollution source tracking in environmental waters

EPA Science Inventory

Microbial source tracking (MST) tools are used to identify sources of fecal pollution for accurately assessing public health risk and implementing best management practices (BMPs). This review focuses on the potential of enteric viruses for MST applications. Following host infect...

Measurement and Modeling of Near Road & Near-Port Air Quality

EPA Science Inventory

Air pollution from mobile sources has been identified by numerous organizations as a potential public health concern. Based upon multiple near-road and near-source monitoring studies, both busy roadways and large emission sources at ports can significantly impact local air qualit...

Multiple fingerprinting analyses in quality control of Cassiae Semen polysaccharides.

PubMed

Cheng, Jing; He, Siyu; Wan, Qiang; Jing, Pu

2018-03-01

Quality control issue overshadows potential health benefits of Cassiae Semen due to the analytic limitations. In this study, multiple-fingerprint analysis integrated with several chemometrics was performed to assess the polysaccharide quality of Cassiae Semen harvested from different locations. FT-IR, HPLC, and GC fingerprints of polysaccharide extracts from the authentic source were established as standard profiles, applying to assess the quality of foreign sources. Analyses of FT-IR fingerprints of polysaccharide extracts using either Pearson correlation analysis or principal component analysis (PCA), or HPLC fingerprints of partially hydrolyzed polysaccharides with PCA, distinguished the foreign sources from the authentic source. However, HPLC or GC fingerprints of completely hydrolyzed polysaccharides couldn't identify all foreign sources and the methodology using GC is quite limited in determining the monosaccharide composition. This indicates that FT-IR/HPLC fingerprints of non/partially-hydrolyzed polysaccharides, respectively, accompanied by multiple chemometrics methods, might be potentially applied in detecting and differentiating sources of Cassiae Semen. Copyright © 2018 Elsevier B.V. All rights reserved.

Endophytic Fungi—Alternative Sources of Cytotoxic Compounds: A Review

PubMed Central

Uzma, Fazilath; Mohan, Chakrabhavi D.; Hashem, Abeer; Konappa, Narasimha M.; Rangappa, Shobith; Kamath, Praveen V.; Singh, Bhim P.; Mudili, Venkataramana; Gupta, Vijai K.; Siddaiah, Chandra N.; Chowdappa, Srinivas; Alqarawi, Abdulaziz A.; Abd_Allah, Elsayed F.

2018-01-01

Cancer is a major cause of death worldwide, with an increasing number of cases being reported annually. The elevated rate of mortality necessitates a global challenge to explore newer sources of anticancer drugs. Recent advancements in cancer treatment involve the discovery and development of new and improved chemotherapeutics derived from natural or synthetic sources. Natural sources offer the potential of finding new structural classes with unique bioactivities for cancer therapy. Endophytic fungi represent a rich source of bioactive metabolites that can be manipulated to produce desirable novel analogs for chemotherapy. This review offers a current and integrative account of clinically used anticancer drugs such as taxol, podophyllotoxin, camptothecin, and vinca alkaloids in terms of their mechanism of action, isolation from endophytic fungi and their characterization, yield obtained, and fungal strain improvement strategies. It also covers recent literature on endophytic fungal metabolites from terrestrial, mangrove, and marine sources as potential anticancer agents and emphasizes the findings for cytotoxic bioactive compounds tested against specific cancer cell lines. PMID:29755344