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Sample records for potros pura sangre

  1. Biogas electricity -- The Pura village case study

    SciTech Connect

    Rajabapaiah, P.; Jayakumar, S.; Reddy, A.K.N.

    1993-12-31

    A potentially useful decentralized source of energy is biogas, which is an approximately 60:40 mixture of methane (CH{sub 4}) and carbon dioxide (CO{sub 2}), produced by the anaerobic fermentation of cellulosic biomass materials such as bovine wastes. Since 1987, the traditional system of obtaining water, illumination, and fertilizer in Pura village in south India has been replaced with a community biogas plant electricity-generation system. The technical, managerial, and economical aspects of this system are the subject manner of the present paper. Various subsystems are described, and the problems of operation and maintenance under field conditions are also discussed. A comparison of Pura`s present community biogas system with its traditional means for obtaining water, illumination, and fertilizer shows that the households are winners on all counts, having obtained such benefits as improved hygiene and convenience at relatively low cost. The Pura community biogas plant is held together and sustained by the convergence of individual and collective interests. Noncooperation with the community biogas plant results in a heavy individual price (access to water and light being cut off by the village), which is too great a personal loss to compensate for the minor advantages of noncooperation and noncontribution to collective interests.

  2. The Geologic Story of Colorado's Sangre de Cristo Range

    USGS Publications Warehouse

    Lindsey, David A.

    2010-01-01

    There is no record of the beginning of time in the Sangre de Cristo Range. Almost 3 billion years of Earth history are missing, but the rest is on spectacular display in this rugged mountain landscape. This is the geologic story of the Sangre de Cristo Range.

  3. SANGRE DE CRISTO WILDERNESS STUDY AREA, COLORADO.

    USGS Publications Warehouse

    Johnson, Bruce R.; Ellis, Clarence E.

    1984-01-01

    Mineral surveys were undertaken of a wilderness study area which includes most of the Sangre de Cristo Range of south-central Colorado. Four areas of probable mineral-resource potential for gold, silver, and base metals lie along a northwest structural trend which follows the western margin of the range north of the Great Sand Dunes National Monument and crosses the range south of the monument. An area of probable mineral-resource potential for similar minerals plus tungsten has been identified east of Blanca Peak at the extreme southern end of the study area. Another area of probable mineral-resource potential includes molybdenum mineralization associated with the Rito Alto stock. A small area of probable geothermal resource potential exists on the west side of the area around the Valley View Hot Springs. There is little promise for the occurrence of oil and gas resources.

  4. Spanish Peaks, Sangre de Cristo Range, Colorado

    NASA Technical Reports Server (NTRS)

    2002-01-01

    The Spanish Peaks, on the eastern flank of the Sangre de Cristo range, abruptly rise 7,000 feet above the western Great Plains. Settlers, treasure hunters, trappers, gold and silver miners have long sighted on these prominent landmarks along the Taos branch of the Santa Fe trail. Well before the westward migration, the mountains figured in the legends and history of the Ute, Apache, Comanche, and earlier tribes. 'Las Cumbres Espanolas' are also mentioned in chronicles of exploration by Spaniards including Ulibarri in 1706 and later by de Anza, who eventually founded San Francisco (California). This exceptional view (STS108-720-32), captured by the crew of Space Shuttle mission STS108, portrays the Spanish Peaks in the context of the southern Rocky Mountains. Uplift of the Sangre de Cristo began about 75 million years ago and produced the long north-trending ridges of faulted and folded rock to the west of the paired peaks. After uplift had ceased (26 to 22 million years ago), the large masses of igneous rock (granite, granodiorite, syenodiorite) that form the Peaks were emplaced (Penn, 1995-2001). East and West Spanish Peaks are 'stocks'-bodies of molten rock that intruded sedimentary layers, cooled and solidified, and were later exposed by erosion. East Peak (E), at 12,708 ft is almost circular and is about 5 1/2 miles long by 3 miles wide, while West Peak (W), at 13,623 ft is roughly 2 3/4 miles long by 1 3/4 miles wide. Great dikes-long stone walls-radiate outward from the mountains like spokes of a wheel, a prominent one forms a broad arc northeast of East Spanish Peak. As the molten rock rose, it forced its way into vertical cracks and joints in the sedimentary strata; the less resistant material was then eroded away, leaving walls of hard rock from 1 foot to 100 feet wide, up to 100 feet high, and as long as 14 miles. Dikes trending almost east-west are also common in the region. For more information visit: Sangres.com: The Spanish Peaks (accessed January 16

  5. 77 FR 67830 - Establishment of Sangre de Cristo Conservation Area, Colorado and New Mexico

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-14

    ... Fish and Wildlife Service Establishment of Sangre de Cristo Conservation Area, Colorado and New Mexico... the U.S. Fish and Wildlife Service (Service) has established the Sangre de Cristo Conservation Area as a unit of the National Wildlife Refuge System. The Service established the Sangre de...

  6. Regulation of Escherichia coli purA by purine repressor, one component of a dual control mechanism.

    PubMed

    He, B; Zalkin, H

    1994-02-01

    Escherichia coli purA encodes adenylosuccinate synthetase, one of two enzymes required for synthesis of AMP from IMP. purA is subject to two- to threefold regulation by purR and about twofold regulation by a purR-independent mechanism. The 5'-flanking region of purA confers purR-dependent transcriptional regulation of purA but not the purR-independent regulation. Two operator sites in the 5'-flanking region which bind purine repressor in vitro and are required for in vivo regulation were identified. The purR-independent regulation may be posttranscriptional. It is now established that all transcription units involved in de novo synthesis of purine nucleotides, nine pur operons, as well as purR itself and guaBA, are subject to purR control.

  7. Mutational analysis of the Bacillus subtilis purA operator site.

    PubMed

    Rappu, Pekka; Leppihalme, Mari; Mäntsälä, Pekka

    2005-11-01

    The Bacillus subtilis purine repressor, PurR, regulates many genes involved in purine metabolism. These genes contain a conserved 14-nucleotide inverted repeat (PurBox). Both pur operon and purA, which are regulated by PurR, have this inverted repeat with a 16- or 17-nucleotide spacer, respectively. Mutational studies have earlier shown that PurR binding is dependent on the PurBox of pur operon. In contrast, these studies failed to establish the importance of purA PurBox to PurR binding. To examine this inconsistency, we studied the effects of PurBox mutations both in vivo and in vitro. The data presented here indicate that purA PurBox has a similar role as pur operon PurBox in PurR binding. In addition, our data suggest that the previously proposed classification of the two halves of the Purbox into weak and strong may need to be revised.

  8. Petrology of arkosic sandstones, Pennsylvanian Minturn Formation and Pennsylvanian and Permian Sangre de Cristo Formation, Sangre de Cristo Range, Colorado - data and preliminary interpretations

    USGS Publications Warehouse

    Lindsey, D.A.

    2000-01-01

    This report describes the mineral and chemical composition of immature, arkosic sandstones of the Pennsylvanian Minturn and Pennsylvanian and Permian Sangre de Cristo Formations, which were derived from the Ancestral Rocky Mountains. Located in the Sangre de Cristo Range of southern Colorado, the Minturn and Sangre de Cristo Formations contain some of the most immature, sodic arkoses shed from the Ancestral Rocky Mountains. The Minturn Formation was deposited as fan deltas in marine and alluvial environments; the Sangre de Cristo Formation was deposited as alluvial fans. Arkoses of the Minturn and Sangre de Cristo Formations are matrix-rich and thus may be properly considered arkosic wackes in the terminology of Gilbert (Williams and others, 1954). In general, potassium feldspar and plagioclase are subequal in abundance. Arkose of the Sangre de Cristo Formation is consistently plagioclase-rich; arkose from the Minturn Formation is more variable. Quartz and feldspar grains are accompanied by a few percent rock fragments, consisting mostly of intermediate to granitic plutonic rocks, gneiss, and schist. All of the rock fragments seen in sandstone are present in interbedded conglomerate, consistent with derivation from a Precambrian terrane of gneiss and plutonic rocks much like that exposed in the present Sangre de Cristo Range. Comparison of mineral and major oxide abundances reveals a strong association of detrital quartz with SiO2, all other detrital minerals (totaled) with Al2O3, potassium feldspar plus mica with K2O, and plagioclase with Na2O. Thus, major oxide content is a good predictor of detrital mineralogy, although contributions from matrix and cement make these relationships less than perfect. Detrital minerals and major oxides tend to form inverse relationships that reflect mixtures of varying quantities of minerals; when one mineral is abundant, the abundance of others declines by dilution. In arkose of the Minturn and Sangre de Cristo Formations, the

  9. BD PuraMatrix peptide hydrogel as a culture system for human fetal Schwann cells in spinal cord regeneration.

    PubMed

    Moradi, Fateme; Bahktiari, Mehrdad; Joghataei, Mohammad Taghi; Nobakht, Maliheh; Soleimani, Masoud; Hasanzadeh, Gholamreza; Fallah, Ali; Zarbakhsh, Sam; Hejazian, Leila Beigom; Shirmohammadi, Maryam; Maleki, Fatemeh

    2012-12-01

    BD PuraMatrix peptide hydrogel, a three-dimensional cell culture model of nanofiber scaffold derived from the self-assembling peptide RADA16, has been applied to regenerative tissue repair in order to develop novel nanomedicine systems. In this study with PuraMatrix, self-assembling nanofiber scaffold (SAPNS) and Schwann cells (SCs) were isolated from human fetal sciatic nerves, cultured within SAPNS, and then transplanted into the spinal cord after injury (SCI) in rats. First, the peptide nanofiber scaffold was evaluated via scanning electron microscopy and atomic force microscopy. With phase-contrast microscopy, the appearance of representative human fetal SCs encapsulated in PuraMatrix on days 3, 5, and 7 in 12-well plates was revealed. The Schwann cells in PuraMatrix were cultured for 2 days, and the SCs had active proliferative potential. Spinal cord injury was induced by placing a 35-g weight on the dura of T9-T10 segments for 15 min, followed by in vivo treatment with SAPNS and human fetal SCs (100,000 cells/10 μl/injection) grafted into spinal cord 7 days after SCI. After treatment, the recovery of motor function was assessed periodically using the Basso, Beattie, and Bresnahan scoring system. Eight weeks after grafting, animals were perfusion fixed, and the survival of implanted cells was analyzed with antibody recognizing SCs. Immunohistochemical analysis of grafted lumber segments at 8 weeks after grafting revealed reduced asterogliosis and considerably increased infiltration of endogenous S100(+) cells into the injury site, suggesting that PuraMatrix may play an important role in the repair observed after SAPNS and human fetal SC transplantation.

  10. Heating, cooling, and uplift during Tertiary time, northern Sangre de Cristo Range, Colorado ( USA).

    USGS Publications Warehouse

    Lindsay, D.A.; Andriessen, P.A.M.; Wardlaw, B.R.

    1986-01-01

    Paleozoic sedimentary rocks in a wide area of the northern Sangre de Cristo Range show effects of heating during Tertiary time. Heating is tentatively interpreted as a response to burial during Laramide folding and thrusting and also to high heat flow during Rio Grande rifting. Fission-track ages of apatite across a section of the range show that rocks cooled abruptly below 120oC, the blocking temperature for apatite, approx 19 Ma ago. Cooling was probably in response to rapid uplift and erosion of the northern Sangre de Cristo Range during early Rio Grande rifting.-from Authors

  11. Stratigraphic framework of upper Paleozoic rocks, southeastern Sangre de Cristo Mountains, New Mexico

    USGS Publications Warehouse

    Baltz, E.H.; Myers, D.A.

    1999-01-01

    The Sangre de Cristo Mountains of south-central Colorado and north-central New Mexico are the physiographic expression of a southerly trending Cenozoic structural uplift that plunges gently south to die out in the Great Plains south of Santa Fe and Las Vegas, New Mexico. The uplift is bounded on the west by Neogene downfaulted and downwarped basins of the Rio Grande depression and, on the east, by broad Laramide basins that have sharply folded western limbs. The uplift was modified in Neogene time by local igneous-intrusive doming and normal faulting related to the Rio Grande rift.

  12. Effects of sangre de drago in an in vitro model of cutaneous neurogenic inflammation.

    PubMed

    Pereira, Ulysse; Garcia-Le Gal, Caridad; Le Gal, Grégoire; Boulais, Nicholas; Lebonvallet, Nicolas; Dorange, Germaine; Lefeuvre, Luc; Gougerot, Agnés; Misery, Laurent

    2010-09-01

    Sangre de drago (SD) is a viscous bright red resin collected from Croton lechleri trees that grow in the South American jungle. This sap is used extensively in the native pharmacopoeia to treat skin disorders. Its effectiveness as an inhibitor of neurogenic inflammation has been recently demonstrated. To understand the underlying mechanisms of these effects, we examined the ability of SD to reduce substance P (SP) release in an in vitro model of cutaneous neurogenic inflammation (CNI). This model is based on an enzyme immunoassay of SP (an inducer of CNI) in a porcine co-culture of dorsal root ganglion neurons and keratinocytes. After incubation with different concentrations of SD, we noted an immediate and significant dose-dependent decrease in basal SP release, with average values of 32% at 1% SD (v/v) and 26% at 0.1% (v/v). On the other hand, pretreatment (72 or 1 h) of the co-culture with 1% SD (v/v) was sufficient to induce a 111% (72 h) or 65% (1 h) inhibition of capsaicin-induced SP release, while 0.1% SD (v/v) triggered a 109% (72 h) or 30% (1 h) inhibition. We conclude that sangre de drago is a potent inhibitor of CNI through direct inhibition of neuropeptide release by sensory afferent nerves.

  13. Immunomodulatory activity and chemical characterisation of sangre de drago (dragon's blood) from Croton lechleri.

    PubMed

    Risco, Ester; Ghia, Felipe; Vila, Roser; Iglesias, José; Alvarez, Elida; Cañigueral, Salvador

    2003-09-01

    The immunomodulatory activity of the latex from Croton lechleri (sangre de drago) was determined by in vitro assays. Classical (CP) and alternative (AP) complement pathways activities were determined in human serum. Intracellular generation of reactive oxygen species (ROS) by human polymorphonuclear leukocytes (PMNs) and monocytes, and phagocytosis of opsonised fluorescent microspheres were measured by flow cytometry. Free radical scavenging activity was evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH). Activity on proliferation of murine lymphocytes was also investigated. In addition, anti-inflammatory activity was assayed in vivo by carrageenan-induced rat paw oedema test. Some of the activities were compared with those of the isolated alkaloid taspine. Sangre de drago from Croton lechleri showed immunomodulatory activity. It exhibited a potent inhibitory activity on CP and AP of complement system and inhibited the proliferation of activated T-cells. The latex showed free radical scavenging capacity. Depending on the concentration, it showed antioxidant or prooxidant properties, and stimulated or inhibited the phagocytosis. Moreover, the latex has strong anti-inflammatory activity when administered i. p. Taspine cannot be considered the main responsible for these activities, and other constituents, probably proanthocyanidins, should be also involved.

  14. Laramide structure of the central Sangre de Cristo Mountains and adjacent Raton Basin, southern Colorado

    USGS Publications Warehouse

    Lindsey, D.A.

    1998-01-01

    Laramide structure of the central Sangre de Cristo Mountains (Culebra Range) is interpreted as a system of west-dipping, basement-involved thrusts and reverse faults. The Culebra thrust is the dominant structure in the central part of the range; it dips 30 -55?? west and brings Precambrian metamorphic base-ment rocks over unmetamorphosed Paleozoic rocks. East of the Culebra thrust, thrusts and reverse faults break the basement and overlying cover rocks into north-trending fault blocks; these boundary faults probably dip 40-60?? westward. The orientation of fault slickensides indicates oblique (northeast) slip on the Culebra thrust and dip-slip (ranging from eastward to northward) movement on adjacent faults. In sedimentary cover rocks, east-vergent anticlines overlie and merge with thrusts and reverse faults; these anticlines are interpreted as fault-propagation folds. Minor east-dipping thrusts and reverse faults (backthrusts) occur in both the hanging walls and footwalls of thrusts. The easternmost faults and folds of the Culebra Range form a continuous structural boundary between the Laramide Sangre de Cristo highland and the Raton Basin. Boundary structures consist of west-dipping frontal thrusts flanked on the basinward side by poorly exposed, east-dipping backthrusts. The backthrusts are interpreted to overlie structural wedges that have been emplaced above blind thrusts in the basin margin. West-dipping frontal thrusts and blind thrusts are interpreted to involve basement, but backthrusts are rooted in basin-margin cover rocks. At shallow structural levels where erosion has not exposed a frontal thrust, the structural boundary of the basin is represented by an anticline or monocline. Based on both regional and local stratigraphic evidence, Laramide deformation in the Culebra Range and accompanying synorogenic sedimentation in the western Raton Basin probably took place from latest Cretaceous through early Eocene time. The earliest evidence of uplift and

  15. A role for a highly conserved protein of unknown function in regulation of Bacillus subtilis purA by the purine repressor.

    PubMed

    Rappu, P; Shin, B S; Zalkin, H; Mäntsälä, P

    1999-06-01

    Regulation of the purine biosynthetic gene purA was examined by using a transcriptional fusion to a luciferase reporter gene. Transcription was repressed about 10-fold by the addition of adenine and increased approximately 4.5-fold by the addition of guanosine. This regulation is mediated by a purine repressor (PurR). In a purR mutant, basal expression was increased 10-fold, and there was no further stimulation by guanosine or repression by adenine. An open reading frame, yabJ, immediately downstream from purR was found to have a role in the repression of purA by adenine. Repression by adenine was perturbed in a purR+ yabJ mutant, although guanosine regulation was retained. Mutations in the PurR PRPP binding motif abolished guanosine regulation in the yabJ mutant. Thus, PRPP appears to be required for upregulation by guanosine. The amino acid sequence of YabJ is homologous to the YER057c/YjgF protein family of unknown function.

  16. Deformation mechanisms adjacent to a thrust fault, Sangre de Cristo Mountains, Colorado

    SciTech Connect

    Kelly, J.C.; McConnell, D.A.; Friberg, V.M. . Dept. of Geology)

    1994-04-01

    The purpose of this study is to examine the character of grain-scale deformation adjacent to a Laramide thrust fault in the Sangre de Cristo Mountains. This site represents a window through the hanging wall of a thrust sheet which juxtaposes Precambrian rocks over Pennsylvanian rocks. It provides a rare opportunity to examine deformation mechanisms in the footwall of a basement-involved thrust. Brittle deformation is evident at both outcrop and grain-scale. Filled fractures and slickensides composed of quartz and epidote are present throughout the area, and increase in abundance adjacent to the fault zone, as does the frequency of mesoscopic faulting. Variations in deformation mechanisms can be seen between the Precambrian rocks of the thrust sheet and the Pennsylvanian metasedimentary rocks, and between the metamorphosed arkoses and metapelites within the Pennsylvanian section. Cataclastic textures are present in deformed Precambrian rocks, and the degree of cataclasis is greatest immediately adjacent to the fault zone. Deformation in the Pennsylvanian rocks is largely dependent upon the abundance of fine-grained matrix within each sample. The degree of brittle deformation is negatively correlated to the percentage of matrix. Coarser-grained sections show microscopic faults which offset quartz and feldspar grains. Offsets decrease on the faults as they pass from coarse grains into the matrix.

  17. Ungulate herbivory on alpine willow in the Sangre de Cristo Mountains of Colorado

    USGS Publications Warehouse

    Zeigenfuss, L.C.; Schoenecker, K.A.; Amburg, L.K.V.

    2011-01-01

    In many areas of the Rocky Mountains, elk (Cervus elaphus) migrate from low-elevation mountain valleys during spring to high-elevation subalpine and alpine areas for the summer. Research has focused on the impacts of elk herbivory on winter-range plant communities, particularly on woody species such as willow and aspen; however, little information is available on the effects of elk herbivory on alpine willows. In the Sangre de Cristo Mountains of south central Colorado, select alpine areas appear to receive high levels of summer elk herbivory, while other areas are nearly unbrowsed. In 2005 and 2008, we measured willow height, cover, and utilization on sites that appeared to be used heavily by elk, as well as on sites that appeared to be used lightly, to determine differences between these communities over time. We found less willow cover and shorter willows at sites that received higher levels of browsing compared to those that had lower levels of browsing. Human recreational use was greater at lightly browsed sites than at highly browsed sites. From 2005 to 2008, willow utilization declined, and willow cover and height increased at sites with heavy browsing, likely owing to ownership change of adjacent valley land which led to (1) removal of grazing competition from, cattle at valley locations and (2) increased human use in alpine areas, which displaced elk. We discuss the implications of increased human use and climate change on elk use of these alpine habitats. ?? 2011.

  18. Rapid onset of perfused blood vessels after implantation of ECFCs and MPCs in collagen, PuraMatrix and fibrin provisional matrices.

    PubMed

    Allen, Patrick; Kang, Kyu-Tae; Bischoff, Joyce

    2015-05-01

    We developed an in vivo vascularization model in which human endothelial colony-forming cells (ECFCs) and human mesenchymal progenitor cells (MPCs) form blood vessel networks when co-injected (ECFC + MPC) into nude mice in rat tail type I collagen, bovine fibrin or synthetic peptide PuraMatrix matrices. We used three approaches to determine the onset of functional vascularization when ECFC + MPC suspended in these matrices were implanted in vivo. The first was immunohistochemistry to detect vessels lined by human endothelial cells and filled with red blood cells. The second was in vivo vascular staining by tail vein injection of a mixture of Ulex europaeus agglutinin I (UEA-I), a lectin specific for human endothelium, and Griffonia simplicifolia isolectin B4 (GS-IB4 ), a lectin specific for rodent endothelium. The third approach employed contrast-enhanced ultrasound to measure the perfusion volumes of implants in individual animals over time. Human endothelial-lined tubular structures were detected in vivo on days 1 and 2 after implantation, with perfused human vessels detected on days 3 and 4. Contrast-enhanced ultrasound revealed significant perfusion of ECFC + MPC/collagen implants on days 1-4, at up to 14% perfused vascular volume. ECFC + MPC implanted in fibrin and PuraMatrix matrices also supported perfusion at day 1, as assessed by ultrasound (at 12% and 23% perfused vascular volume, respectively). This model demonstrates that ECFC + MPC suspended in any of the three matrices initiated a rapid onset of vascularization. We propose that ECFC + MPC delivered in vivo provide a means to achieve rapid perfusion of tissue-engineered organs or for in situ tissue repair.

  19. Effects of Sangre de Drago from Croton lechleri Muell.-Arg. on the production of active oxygen radicals.

    PubMed

    Desmarchelier, C; Witting Schaus, F; Coussio, J; Cicca, G

    1997-10-01

    The total reactive antioxidant potential (TRAP) of 'Sangre de Drago' from Croton lechleri (Euphorbiaceae) was determined by monitoring the intensity of luminol enhanced chemiluminescence enhanced by peroxyl radicals derived from thermolysis of 2,2'-azo-bis(2-amidinopropane). The TRAP index was calculated as 935.4 +/- 141 microM, measured as equivalents of Trolox concentration. On the other hand, the additive incorporation of lower concentrations yielded an instantaneous increase in chemiluminescence, suggesting a prooxidant activity at these levels. DNA sugar damage induced by Fe(II) salts was also used to determine the capacity of the latex to suppress hydroxyl radical-mediated degradation of DNA. As in the case of luminol enhanced chemiluminescence, Sangre de Drago was highly effective in reducing oxidation of DNA at higher concentrations, but showed an increase in the production of TBARS at lower doses, as compared to the control. Finally, antioxidant activity was tested using hydroperoxide-initiated chemiluminescence in rat liver homogenates, and the latex showed an increase in light emission, suggesting the presence of prooxidant compounds.

  20. Minturn and Sangre de Cristo Formations of southern Colorado: a prograding fan-delta to alluvial-fan sequence shed from ancestral Rocky Mountains

    SciTech Connect

    Lindsey, D.A.; Clark, R.F.; Ashe, S.J.; Flores, R.J.

    1983-08-01

    The Pennsylvanian Minturn and Pennsylvanian-Permian Sangre de Cristo Formations of the northern Sangre de Cristo Mountains comprise a 3,800-m (12,500-ft) thick progradational sequence of coarse clastic sediments shed into a basin on the northeastern side of the late Paleozoic San Luis-Uncompahgre highland. From bottom to top, the mostly marine Minturn Formation contains probable deltaic (700 m, 2,300 ft), mixed fan-delta and prodelta (800 m, 2,600 ft), and fan-delta (600 m, 2,000 ft) deposits; the mostly continental Sangre de Cristo Formation contains distal alluvial fan (600 m, 2,000 ft) and proximal alluvial fan (1,100m 3,600 ft) deposits. At least three episodes of uplift are indicated by the distribution of unconformities, geometry of intertonguing facies, and abrupt vertical changes in facies. The deltaic and mixed fan-delta and prodelta deposits of the lower and middle parts of the Minturn Formation consist of coarsening-upward cycles 30 to 300 m (100 to 1,000 ft) thick of shale, siltstone, sandstone, and conglomeratic sandstone. The mixed deposits in the middle part of the Minturn contain cycles of shale, proximalturbidite sandstones, and conglomeratic sandstone; such cycles are interpreted as deposits of submarine fans overridden by fan deltas. Continental deposits of the lower member of the Sangre de Cristo Formation consist of fining-upward cycles 2 to 37 m (6.5 to 121 ft) thick of cross-bedded conglomerate, sandstone, and siltstone deposited by braided streams on the distal parts of alluvial fans.

  1. Controls on variation of calcite content in arkose beds of the Sangre de Cristo Formation, (Pennsylvanian-Permian) Colorado

    SciTech Connect

    Wysong, J.R.; Bain, R.J. . Dept. of Geology)

    1994-04-01

    Arkosic conglomerates and sandstones of the Pennsylvanian-Permian Sangre de Cristo Formation of south-central Colorado were deposited on alluvial plains and nearshore marine shelves adjacent to the highlands of the Ancestral Rocky Mountains. Thin limestone units occur locally, however calcite content of arkoses varies independent of these limestones. The thinly bedded to laminated arkoses contain abundant detrital orthoclase and plagioclase feldspars, micas and quartz. Authigenic clay (kaolinite) and calcite occur both as void-filling cement and replacement of feldspars. Fine-grained arkoses possess more calcite and authigenic clay than their coarse-grained counterparts. Calcite occurs as plagioclase replacement in fine-grained samples whereas in coarse-grained rocks it fills interstitial voids. Calcite content in fine-grained arkoses is low where laminae are preserved and increases with the presence of bioturbation. Diagenetic processes responsible for calcite and clay content of these arkoses were controlled by several factors including original sediment texture, composition, and grain orientation. Plagioclase has been altered to produce calcite and clay more than orthoclase. Permeability of coarse-grained rocks was higher and resulted in primarily void-filling cement. In fine-grained arkoses, permeability was less and water remained in contact with grains longer thereby altering plagioclase. Aligned mica grains of laminae retarded flow and impeded diagenetic alteration whereas bioturbation disrupted grain orientation thereby enhancing diagenesis.

  2. Evaluation of thrusting and folding of the Deadman Creek Thrust Fault, Sangre de Cristo range, Saguache County, Colorado

    NASA Astrophysics Data System (ADS)

    Weigel, Jacob F., II

    The Deadman Creek Thrust Fault was mapped in a structural window on the west side of the Sangre de Cristo Range. The study area, located in southern Colorado, is a two square mile area halfway between the town of Crestone and the Great Sand Dunes National Park. The Deadman Creek Thrust Fault is the center of this study because it delineates the fold structure in the structural window. The fault is a northeast-directed low-angle thrust folded by subsequent additional compression. This study was directed at understanding the motion of the Deadman Creek Thrust Fault as affected by subsequent folding, and the driving mechanism behind the folding of the Pole Creek Anticline as part of a broader study of Laramide thrust faulting in the range. This study aids in the interpretation of the geologic structure of the San Luis Valley, which is being studied by staff of the United States Geological Survey (USGS), to understand Rio Grande Rift basin evolution by focusing on rift and pre-rift tectonic activity. It also provides a geologic interpretation for the Saguache County Forest Service, Great Sand Dunes National Park, and its visitors. The Sangre de Cristo Mountain Range has undergone tectonic events in the Proterozoic, Pennsylvanian (Ancestral Rocky Mountains), Cretaceous-Tertiary (Laramide Orogeny) and mid-Tertiary (Rio Grande Rift). During the Laramide Orogeny the Deadman Creek Thrust Fault emplaced Proterozoic gneiss over Paleozoic sedimentary rocks and Proterozoic granodiorite in the area. Continued deformation resulted in folding of the fault to form the Pole Creek Anticline. The direction of motion of both the fault and fold is northeastward. A self-consistent net of cross-sections and stereonet plots generated from existing and new field data show that the anticline is an overturned isoclinal fold in Pole Creek Canyon, which shows an increasing inter-limb angle and a more vertical axial surface northwestward toward Deadman Creek Canyon. Southwest-directed apparent

  3. Preliminary Geologic Map of the Culebra Peak Area, Sangre de Cristo Mountains, Las Animas and Costilla Counties, Colorado

    USGS Publications Warehouse

    Fridrich, Christopher J.; Kirkham, Robert M.

    2008-01-01

    This geologic map provides new geologic mapping at 1:50,000-scale in the Culebra Peak area of the Sangre de Cristo Mountains of south-central Colorado. The map area includes all of the El Valle Creek, Stonewall, Culebra Peak, and Torres 7.5' quadrangles. Paleoproterozoic crystalline basement rocks are exposed along the crest of the Culebra Range which include a calc-alkaline gneiss sequence and a metasedimentary and bimodal metavolcanic sequence which are strongly foliated and display a northeast-southwest oriented structural trend. These rocks are intruded by several large granitic bodies and smaller amphibolitic and pegmatitic bodies which are also foliated. These basement rocks are intruded by a set of younger Neoproterozoic to lower Paleozoic gabbro dikes which are nonfoliated. These crystalline rocks are overlain to the east of the Culebra Range by a thick sequence of Phanerozoic sedimentary rocks which include upper Paleozoic syn-tectonic sedimentary rocks of the Colorado Trough related to the Ancestral Rocky Mountains, Mesozoic post-tectonic sedimentary rocks, Cretaceous interior seaway sediments, and Laramide-age syn-tectonic sedimentary rocks of the Raton Basin. These rocks are faulted and folded by Laramide-age deformation. Tertiary igneous and volcaniclastic rocks that postdate the Laramide Orogeny are exposed throughout the map area and to the west of the Culebra Range, syntectonic sedimentary and volcanic rocks of the Sante Fe Group were deposited as fill in basins of the Rio Grande rift. These deposits are cut by rift-related extensional faults. Surficial units include alluvial, lacustrine, glacial, and mass-wasting deposits.

  4. {open_quotes}Black Gold{close_quotes} leads to new structural interpretation, Northern Sangre de Cristo Mountains/Northeast San Luis Basin

    SciTech Connect

    Watkins, T.A.; Belcher, J.S.; Gries, R.

    1995-06-01

    In the course of exploring for gold along the east margin of the Rio Grande Rift (northern Sangre de Cristo Mountains and northeastern San Luis Basin) live Cretaceous oil was discovered in fractured Precambrian gneiss in 25 of 42 shallow drill holes. Geologic mapping located two outcrops of Mesozoic sediments along the west flank of the Sangre de Cristo Mountains. Mancos Shale, Dakota Group and Morrison Formation sediments were identified from 17 drill holes. These are the first known occurrences of Mesozoic sediments in the area. Previous investigations had concluded that the Mesozoic section eroded from the San Luis uplift during the Laramide. Surface and subsurface geologic data was integrated with gravity, magnetic and seismic surveys for a new structural interpretation. The San Luis Basin is separated from the mountains by an intermediate block and the main basin-bounding fault is three miles west-southwest of the mountain front. A major low-angle, normal fault or detachment fault is related to Miocene rifting. A thick section of Mesozoic sediments are interpreted to be present in the hanging wall of this low angle fault. Buried and thermally matured in a Laramide intermountane basin, these sediments are likely the source of the present day oil found in Precambrian rocks.

  5. Review of antiviral and immunomodulating properties of plants of the Peruvian rainforest with a particular emphasis on Una de Gato and Sangre de Grado.

    PubMed

    Williams, J E

    2001-12-01

    Viral diseases, including emerging and chronic viruses, are an increasing worldwide health concern. As a consequence, the discovery of new antiviral agents from plants has assumed more urgency than in the past. A number of native Amazonian medicines of plant origin are known to have antimicrobial and anti-inflammatory activity, although only a few have been studied for their antiviral properties and immunomodulating effects. Those most studied include: Sangre de Grado (drago) (Croton lechleri) in the Euphorbiaceae family and Una de Gato (Uncaria tomentosa) in the Rubiaceae family. This article reviews the chemical composition, pharmacological properties, state of current research, clinical use, and potential antiviral and immunomodulating activity of these and other plants from the Peruvian Amazon.

  6. Integration of geology, non-seismic geophysics and seismic data in a structurally complex, frontier oil play: Northern Sangre de Cristo Mountains/Northeast San Luis Basin, Colorado

    SciTech Connect

    Watkins, T.A.; Belcher, J.S.; Gries, R.

    1995-06-01

    The discovery of live Cretaceous oil in mineral exploration drill holes, followed by the identification of Mesozoic sediments in outcrop and in shallow drill holes, has lead to an integrated approach to exploration of a structurally complex, frontier oil play in south-central Colorado. Gravity, aeromagnetic, magnetotelluric (MT), and time domain electromagnetic (TDEM) data were acquired and interpreted in the initial stages of the project. Models derived from the geophysical data were augmented with geologic field work to explain specific anomalies. Interpretation of the gravity data was constrained by density measurements on representative rock samples collected in the field. Seismic data, acquired in the most recent exploration stage, provided confirmation and modification of the basin margin geometry. Velocity data from the seismic was integrated with resistivity, density, magnetic and geologic data to predict lithologies on an intermediate fault block located between the Sangre de Cristo Mountains and the San Luis Basin.

  7. Non-seismic geophysics compared and integrated with seismic in a frontier oil play: Northern Sangre de Cristo Mountains/Northeast San Luis Basin, Colorado

    SciTech Connect

    Longacre, M.B.; Christopherson, K.R.; Gries, R.

    1995-06-01

    Four non-seismic geophysical tools have made a significant contribution to a new geological interpretation of the northern Sangre de Cristo Mountains/northeast San Luis Basin of south-central Colorado. Gravity, aeromagnetic, magnetotelluric, (MT) and time domain electromagnetic (TDEM) data were acquired and interpreted during the early stages of exploration. Two-dimensional modeling of the gravity and magnetics placed the main, basin-bounding fault three miles southwest of the mountain front, identified an intermediate fault block at the basin margin and identified a thick sequence of non-magnetic, intermediate density rocks on top of this block. A thick section of Mesozoic sediments is interpreted, supported by the discovery of outcrops of Cretaceous sediments and live Cretaceous oil. Magnetotelluric data was acquired to confirm the presence of Mesozoic sediments and depth to basement. Detailed TDEM data has been useful in correlating the MT with surface geology. Integration of the gravity, magnetic and MT data with seismic resulted in minor modifications to the new geological model.

  8. Petrographic analysis and interpretation of the Whiskey Creek Pass Ls Member, Minturn and Madera Fm, Sangre de Cristo range, south-central Colorado

    SciTech Connect

    Hamilton, K.D. . Geology Dept.)

    1994-04-01

    The Minturn and Madera formations of the Sangre de Cristo Mountains are laterally equivalent facies made up of interbedded carbonates and terrigenous clastic material deposited in the central Colorado trough during the mid Pennsylvanian period. To date, the Whiskey Creek Pass Ls Member (WCPLs) of the upper Minturn and Madera Fm. is the only marker unit of south-central Colorado that has been lithostratigraphically correlated for more than a few miles. This correlation is largely the result of the relative abundance of pure oolitic constituents within the WCPLs. As of yet, there has been no significant petrographic study of the lithologic character of the WCPLs. The WCPLs is well exposed in south-central Colorado containing overturned beds that dip approximately 70[degree] to the west. Six stratigraphic sections were measured and described from three separate localities: four sections were measured and described from three separate localities: four sections were measured on the north ridge of Trinchera Peak, one section at La Veta Pass, and one on Forbes Ranch near Fort Garland. Petrographic analysis shows that similar bioclastic constituents including brachiopods, echinoderms, mollusks, and foraminifera are found within all sections. These fossils are usually found in thin bands surrounded by oolitic and/or sandy limestone layers. Both radial and tangential ooids are evident but many are poorly preserved due to internal replacement by sparite. Oolitic nuclei are commonly composed of quartz, feldspar or bioclasts. Sparite or microspar is the main cementing agent. Diagenetic features such as compaction, syntaxial overgrowths, and replacement are common. Preliminary analysis suggests deposition occurred in a shallow marine environment close to an area of relatively high relief. Oolitic shoals and marginal lagoons predominate with siliclastic material suggesting proximal or distal localities of deposition for various units.

  9. Reference section for the Minturn Formation (Middle Pennsylvanian), northern Sangre de Cristo Range, Custer County, Colorado

    USGS Publications Warehouse

    Lindsey, D.A.; Clark, R.F.; Soulliere, S.J.

    1985-01-01

    The reference section was measured by tape and compass in the summer of 1980; observations were recorded on a microcassette tape recorder in the field and transcribed in the office. This method permitted rapid acquisition of data on thickness, mature of contacts, color, grain size, and sedimentary features. These data are shown on the graphic section for each distinct rock unit. Rock units having common attributes or genetic relationships have been grouped together for descriptive and interpretative purposes.

  10. "Romancero gitano y Bodas de sangre," Federico Garcia Lorca. Performance Guides to Spanish Texts.

    ERIC Educational Resources Information Center

    Gies, David Thatcher, Comp.

    This performance guide is the result of work conducted at the University of Virginia's National Endowment for the Humanities Summer Institute, 1989, on "Spanish Literature in Performance," in which 25 secondary school Spanish teachers studied Spanish texts from the perspective of classroom performance to deepen knowledge of the texts and discover…

  11. SP-303, an antiviral oligomeric proanthocyanidin from the latex of Croton lechleri (Sangre de Drago).

    PubMed

    Ubillas, R; Jolad, S D; Bruening, R C; Kernan, M R; King, S R; Sesin, D F; Barrett, M; Stoddart, C A; Flaster, T; Kuo, J; Ayala, F; Meza, E; Castañel, M; McMeekin, D; Rozhon, E; Tempesta, M S; Barnard, D; Huffman, J; Smee, D; Sidwell, R; Soike, K; Brazier, A; Safrin, S; Orlando, R; Kenny, P T; Berova, N; Nakanishi, K

    1994-09-01

    SP-303, a large proanthocyanidin oligomer isolated from the latex of the plant species Croton lechleri (Eupborbiaceae) has demonstrated broad activity against a variety of DNA and RNA viruses. In cell culture, SP-303 exhibits potent activity against isolates and laboratory strains of respiratory syncytial virus (RSV), influenza A virus (FLU-A) and parainfluenza virus (PIV). Parallel assays of SP-303 and ribavirin showed comparable activity against these viruses. SP-303 also exhibits significant inhibitory activity against herpesvirus (HSV) types 1 and 2, including herpesviruses resistant to acyclovir and foscarnet. Inhibition was also observed against hepatitis A and B viruses. The antiviral mechanism of SP-303 seems to derive from its direct binding to components of the viral envelope, resulting in inhibition of viral attachment and penetration of the plasma membrane. Antiviral effects of SP-303 were measured by three distinct methods: CPE, MTT and precursor uptake/incorporation. Cytotoxicity endpoints were markedly greater than the respective antiviral endpoints. SP-303 exhibited activity in RSV-infected cotton rats and African green monkeys, PIV-3-infected cotton rats, HSV-2 infected mice and guinea pigs and FLU-A-infected mice. The most successful routes of SP-303 administration for producing efficacy were: topical application to HSV-2- genital lesions in mice and guinea pigs, aerosol inhalation to FLU-A-infected mice and PIV-3-infected cotton rats, and oral dosage to RSV-infected cotton rats. A variety of toxicological evaluations demonstrated the safety of SP-303, particularly orally, which was predictable, since condensed tannins are a common dietary component. It is notable that the larger proanthocyanidins as a class have high antiviral activity, whereas most of the monomers are inactive. Clinical trials are ongoing to evaluate SP-303 as a therapeutic antiviral agent.

  12. Thermal and thermomechanical calculations of deep-rock nuclear waste disposal with the enhanced SANGRE code

    SciTech Connect

    Heuze, F.E.

    1983-03-01

    An attempt to model the complex thermal and mechanical phenomena occurring in the disposal of high-level nuclear wastes in rock at high power loading is described. Such processes include melting of the rock, convection of the molten material, and very high stressing of the rock mass, leading to new fracturing. Because of the phase changes and the wide temperature ranges considered, realistic models must provide for coupling of the thermal and mechanical calculations, for large deformations, and for steady-state temperature-depenent creep of the rock mass. Explicit representation of convection would be desirable, as would the ability to show fracture development and migration of fluids in cracks. Enhancements to SNAGRE consisted of: array modifications to accommodate complex variations of thermal and mechanical properties with temperature; introduction of the ability of calculate thermally induced stresses; improved management of the minimum time step and minimum temperature step to increase code efficiency; introduction of a variable heat-generation algorithm to accommodate heat decay of the nuclear materials; streamlining of the code by general editing and extensive deletion of coding used in mesh generation; and updating of the program users' manual. The enhanced LLNL version of the code was renamed LSANGRE. Phase changes were handled by introducing sharp variations in the specific heat of the rock in a narrow range about the melting point. The accuracy of this procedure was tested successfully on a melting slab problem. LSANGRE replicated the results of both the analytical solution and calculations with the finite difference TRUMP code. Following enhancement and verification, a purely thermal calculation was carried to 105 years. It went beyond the extent of maximum melt and into the beginning of the cooling phase.

  13. "¿Puras Groserías?": Rethinking the Role of Profanity and Graphic Humor in Latin@ Students' Bilingual Wordplay

    ERIC Educational Resources Information Center

    Martínez, Ramón Antonio; Morales, P. Zitlali

    2014-01-01

    This article explores the role of profanity and graphic humor in the bilingual wordplay of Latin@ middle school students. We highlight the creativity, skill, and communicative competence embedded in this transgressive wordplay, revealing how these youth employed profanity and graphic humor to index ethnic solidarity and construct bilingual…

  14. Construction and Validation of a 14-Year Cardiovascular Risk Score for Use in the General Population: The Puras-GEVA Chart

    PubMed Central

    Artigao-Ródenas, Luis Miguel; Carbayo-Herencia, Julio Antonio; Palazón-Bru, Antonio; Divisón-Garrote, Juan Antonio; Sanchis-Domènech, Carlos; Vigo-Aguiar, Isabel; Gil-Guillén, Vicente Francisco

    2015-01-01

    Abstract The current cardiovascular risk tables are based on a 10-year period and therefore, do not allow for predictions in the short or medium term. Thus, we are unable to take more aggressive therapeutic decisions when this risk is very high. To develop and validate a predictive model of cardiovascular disease (CVD), to enable calculation of risk in the short, medium and long term in the general population. Cohort study with 14 years of follow-up (1992–2006) was obtained through random sampling of 342,667 inhabitants in a Spanish region. Main outcome: time-to-CVD. The sample was randomly divided into 2 parts [823 (80%), construction; 227 (20%), validation]. A stepwise Cox model was constructed to determine which variables at baseline (age, sex, blood pressure, etc) were associated with CVD. The model was adapted to a points system and risk groups based on epidemiological criteria (sensitivity and specificity) were established. The risk associated with each score was calculated every 2 years up to a maximum of 14. The estimated model was validated by calculating the C-statistic and comparison between observed and expected events. In the construction sample, 76 patients experienced a CVD during the follow-up (82 cases per 10,000 person-years). Factors in the model included sex, diabetes, left ventricular hypertrophy, occupational physical activity, age, systolic blood pressure × heart rate, number of cigarettes, and total cholesterol. Validation yielded a C-statistic of 0.886 and the comparison between expected and observed events was not significant (P: 0.49–0.75). We constructed and validated a scoring system able to determine, with a very high discriminating power, which patients will develop a CVD in the short, medium, and long term (maximum 14 years). Validation studies are needed for the model constructed. PMID:26632692

  15. Using Young Adult Literature to Provide Case Studies for Discussion of Bullying: An Analysis of the 2014 Pura Belpré Award Winner

    ERIC Educational Resources Information Center

    Cummins, Amy

    2014-01-01

    Analyzing Meg Medina's young adult novel "Yaqui Delgado Wants to Kick Your Ass" (2013) through the lens of multidisciplinary research on school bullying provides a case study in using young adult literature (YAL) to stimulate high school discussions about bullying. Strategies for using anti-bullying YAL and recommendations of additional…

  16. English-Spanish Cognates and the Pura Belpré Children's Award Books: Reading the Word and the World

    ERIC Educational Resources Information Center

    Montelongo, José A.; Hernández, Anita C.; Herter, Roberta J.

    2014-01-01

    English-Spanish cognates are an important subset of words in both the English and Spanish languages. Cognates are words that possess identical or nearly identical spellings and meanings in both languages as a result of being derived from Latin and Greek. Of major importance is the fact that many of the more than 20,000 cognates in English are…

  17. Geologic remote sensing study of the Hayden pass-Orient Mine Area, Northern Sangre de Cristo Mountains, Colorado

    NASA Technical Reports Server (NTRS)

    Wychgram, D. C.

    1972-01-01

    Remote sensor data from a NASA Convair 990 radar flight and Mission 101 and 105 have been interpreted and evaluated. Based on interpretation of the remote sensor data, a geologic map has been prepared and compared with a second geologic map, prepared from interpretation of both remote sensor data and field data. Comparison of the two maps gives one indication of the usefulness and reliability of the remote sensor data. Color and color infrared photography provided the largest amount of valuable information. Multiband photography was of lesser value and side-looking radar imagery provided no new information that was not available on small scale photography. Thermal scanner imagery proved to be a very specialized remote sensing tool that should be applied to areas of low relief and sparse vegetation where geologic features produce known or suspected thermal contrast. Low sun angle photography may be a good alternative to side-looking radar imagery but must be flown with critical timing.

  18. ¿Cómo puede usted contribuir a la investigación médica? Done su sangre, sus tejidos y otras muestras

    Cancer.gov

    Explica la importancia de la donación de tejidos, responde a posibles preocupaciones y anima a los pacientes a que hablen con sus proveedores de cuidados para la salud acerca de la donación de muestras biológicas.

  19. Measured sections and discussion of the main turbidite member, Middle Pennsylvanian Minturn Formation, northern Sangre de Cristo Range, Custer and Saguache counties, Colorado

    USGS Publications Warehouse

    Soulliere, S.J.; DeAngelis, B.L.; Lindsey, D.A.

    1984-01-01

    The main turbidite member is the thickest and most extensive of the intervals of prodelta turbidites in the Minturn Formation. Each turbidite interval is part of a coarsening upward sequence interpreted as a prograding fan delta. A typical prograding cycle consists of prodelta marine shale and siltstone, prodelta turbidite sandstones, delta-front sandstone and conglomerate, and deltaic and alluvial-plain sandstone, siltstone, and shale. Fossils of 1and plants (mostly Calamites, including some in growth position) are locally abundant in deltaic and alluvial sediments of the prograding cycles. The turbidites are regarded as having been deposited offshore from alluvial systems.

  20. You Are the Heart of Your Family -- Take Care of It

    MedlinePlus

    ... en la sangre, la presión arterial y el colesterol. Las concentraciones altas de azúcar en la sangre ... que hace que su corazón trabaje más. El colesterol malo (el colesterol LDL) se acumula y tapa ...

  1. In vivo effect of mutations at the PRPP binding site of the Bacillus subtilis purine repressor.

    PubMed

    Rappu, Pekka; Pullinen, Terhi; Mäntsälä, Pekka

    2003-11-01

    The Bacillus subtilis PurR mediates adenine repression and guanosine induction of purA. PRPP inhibits binding of PurR to DNA in vitro. Mutations in the PRPP binding motif of PurR caused strong repression regardless of purine exclusions or additions, establishing the role of PRPP as regulator of PurR.

  2. Intergenerational Beliefs of Mothers and Grandmothers regarding Early Childhood Stimulation in (Rural) Jammu, India

    ERIC Educational Resources Information Center

    Sharma, Neeru; Sapru, Ruchira; Mahajan, Ruchi

    2009-01-01

    The present research was conducted to study the intergenerational differences in parental beliefs of the Lobana community in the rural district of Jammu in the Jammu and Kashmir state of India. The sample comprised 30 mothers and 30 grandmothers, selected from the R.S. Pura tehsil of the Jammu district. Data was collected using a modified parental…

  3. BMP2 induced osteogenic differentiation of human umbilical cord stem cells in a peptide-based hydrogel scaffold

    NASA Astrophysics Data System (ADS)

    Lakshmana, Shruthi M.

    Craniofacial tissue loss due to traumatic injuries and congenital defects is a major clinical problem around the world. Cleft palate is the second most common congenital malformation in the United States occurring with an incidence of 1 in 700. Some of the problems associated with this defect are feeding difficulties, speech abnormalities and dentofacial anomalies. Current treatment protocol offers repeated surgeries with extended healing time. Our long-term goal is to regenerate bone in the palatal region using tissue-engineering approaches. Bone tissue engineering utilizes osteogenic cells, osteoconductive scaffolds and osteoinductive signals. Mesenchymal stem cells derived from human umbilical cord (HUMSCs) are highly proliferative with the ability to differentiate into osteogenic precursor cells. The primary objective of the study was to characterize HUMSCs and culture them in a 3D hydrogel scaffold and investigate their osteogenic potential. PuraMatrix(TM) is an injectable 3D nanofiber scaffold capable of self-assembly when exposed to physiologic conditions. Our second objective was to investigate the effect of Bone Morphogenic Protein 2 (BMP2) in enhancing the osteogenic differentiation of HUMSCs encapsulated in PuraMatrix(TM). We isolated cells isolated from Wharton's Jelly region of the umbilical cord obtained from NDRI (New York, NY). Isolated cells satisfied the minimal criteria for mesenchymal stem cells (MSCs) as defined by International Society of Cell Therapy in terms of plastic adherence, fibroblastic phenotype, surface marker expression and osteogenic differentiation. Flow Cytometry analysis showed that cells were positive for CD73, CD90 and CD105 while negative for hematopoietic marker CD34. Alkaline phosphatase activity (ALP) of HUMSCs showed peak activity at 2 weeks (p<0.05). Cells were encapsulated in 0.2% PuraMatrix(TM) at cell densities of 10x104, 20x104, 40x10 4 and 80x104. Cell viability with WST and proliferation with Live-Dead cell assays

  4. Clinical phenotype and candidate genes for the 5q31.3 microdeletion syndrome.

    PubMed

    Hosoki, Kana; Ohta, Tohru; Natsume, Jun; Imai, Sumiko; Okumura, Akihisa; Matsui, Takeshi; Harada, Naoki; Bacino, Carlos A; Scaglia, Fernando; Jones, Jeremy Y; Niikawa, Norio; Saitoh, Shinji

    2012-08-01

    Array-based technologies have led to the identification of many novel microdeletion and microduplication syndromes demonstrating multiple congenital anomalies and intellectual disability (MCA/ID). We have used chromosomal microarray analysis for the evaluation of patients with MCA/ID and/or neonatal hypotonia. Three overlapping de novo microdeletions at 5q31.3 with the shortest region of overlap (SRO) of 370 kb were detected in three unrelated patients. These patients showed similar clinical features including severe neonatal hypotonia, neonatal feeding difficulties, respiratory distress, characteristic facial features, and severe developmental delay. These features are consistent with the 5q31.3 microdeletion syndrome originally proposed by Shimojima et al., providing further evidence that this syndrome is clinically discernible. The 370 kb SRO encompasses only four RefSeq genes including neuregulin 2 (NRG2) and purine-rich element binding protein A (PURA). NRG2 is one of the members of the neuregulin family related to neuronal and glial cell growth and differentiation, thus making NRG2 a good candidate for the observed phenotype. Moreover, PURA is also a good candidate because Pura-deficient mice demonstrate postnatal neurological manifestations.

  5. United World Prep Schools Seek Global Unity and Acculturate U.S. Teachers

    ERIC Educational Resources Information Center

    Martinez, Tony P.; Martinez, Alison P.

    2005-01-01

    United World College of the American West (UWC-USA) which was founded in 1982 by the Occidental Petroleum magnate and philanthropist, Armand Hammer, is an upper-secondary school with 200 students and two dozen faculty from 80 countries or more. Situated amid traditional Hispanic settlements in New Mexico's scenic Sangre de Cristo Mountains,…

  6. Land, Speculation, and Manipulation on the Pecos

    ERIC Educational Resources Information Center

    Bogener, Stephen

    2008-01-01

    The Pecos River of the nineteenth century, unlike its faint twenty-first century shadow, was a formidable watercourse. The river stretches some 755 miles, from the Sangre de Cristo Mountains northeast of Santa Fe to its eventual merger with the Rio Grande. Control over the public domain of southeastern New Mexico came from controlling access to…

  7. Blood Test: Glucose

    MedlinePlus

    ... Things to Know About Zika & Pregnancy Blood Test: Glucose KidsHealth > For Parents > Blood Test: Glucose Print A A A Text Size What's in ... de sangre: glucosa What It Is A blood glucose test measures the amount of glucose (the main ...

  8. Curing the Medical Manpower Shortage

    ERIC Educational Resources Information Center

    Murphy, Betty

    1973-01-01

    The OEO-funded Sangre de Cristo Comprehensive Health System in Costilla and Conejos Counties, Colorado, and northern Taos County, New Mexico, utilizes medical practitioners who are certified to practice a variety of medical techniques under the supervision of licensed physicians. (JM)

  9. 21. Photographic copy of 1915 linen drawing of reservoir and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. Photographic copy of 1915 linen drawing of reservoir and hydroelectric power plant. Approximately seven feet by three and one half feet. Delineator unknown, original currently located in the Sangre de Cristo Water Company drawing files. - Two Mile Reservoir, Santa Fe River, intersection of Canyon & Cerro Gordo Roads, Santa Fe, Santa Fe County, NM

  10. 23. Photographic copy of 1883 ink and water color drawing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. Photographic copy of 1883 ink and water color drawing of the Old Stone Dam. Original located in the office of the director of the Sangre de Cristo Water Company. - Two Mile Reservoir, Santa Fe River, intersection of Canyon & Cerro Gordo Roads, Santa Fe, Santa Fe County, NM

  11. 22. Photographic copy of 1889 linen drawing of reservoir. Approximately ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. Photographic copy of 1889 linen drawing of reservoir. Approximately two and a half feet by four feet. Delineator unknown, original currently located in the Sangre de Cristo Water Company files. - Two Mile Reservoir, Santa Fe River, intersection of Canyon & Cerro Gordo Roads, Santa Fe, Santa Fe County, NM

  12. The Spanish external quality assessment scheme for lead in blood.

    PubMed

    Marcuello, D

    1996-01-01

    In 1985 the Instituto Nacional de Seguridad e Higiene en el Trabajo (INSHT) established the "Programa Interlaboratorios de Control de Calidad de Plomo en Sangre (PICC-PbS)". The operation of this scheme is explained, criteria for evaluation of laboratory performance are defined and some results obtained are reviewed.

  13. Geology along Mosca Pass Trail, Great Sand Dunes National Park and Preserve, Colorado

    USGS Publications Warehouse

    Lindsey, David A.; Klein, Terry L.; Valdez, Andrew; Webster, Robert J.

    2012-01-01

    Mosca Pass Trail takes the hiker on a journey into the Earth's crust. Here you can see the results of tremendous tectonic forces that bend and tear rocks apart and raise mountain ranges. The trail begins near the Sangre de Cristo fault, which separates the Sangre de Cristo Range from the San Luis Valley. The valley is part of the Rio Grande rift, a series of fault basins extending from southern New Mexico to central Colorado, wherein the Earth's crust has been pulled apart during the last 30 million years. Thousands of feet of sediment, brought by streams mostly from the Sangre de Cristo Range, fill the San Luis Valley beneath the Great Sand Dunes. The trail ends at Mosca Pass overlooking Huerfano Park. The park is part of the larger Raton Basin, formed by compression of the Earth's crust during the Laramide orogeny, which occurred 70–40 million years ago. Massive highlands, the remnants of which are preserved in the Sangre de Cristo Range, were uplifted and pushed over the western side of the Raton Basin. Streams eroded the highland as it rose and filled the Raton Basin with sediment. After the sediment was compacted and cemented to form sedimentary rock, the Huerfano River and other streams began to excavate the basin. Over an unknown but long timespan that probably lasted millions of years, relatively soft sedimentary rocks were removed by the river to form the valley we call "Huerfano Park." Between the ends of the trail, the hiker walks through an erosional "window," or opening, into red sedimentary rocks overridden by gneiss, a metamorphic rock, during the Laramide orogeny. This window gives the hiker a glimpse into the Laramide highland of 70–40 million years ago that preceded the present-day Sangre de Cristo Range. The window is the focus of this trail guide. At the east end of the trail, near Mosca Pass, another trail follows the ridgeline south to Carbonate Mountain. Immediately after reaching the first summit above tree line, this trail crosses a

  14. Trasforiiazioni Termoelastiche Finite di Solidi Incomprimibili

    NASA Astrophysics Data System (ADS)

    Signorini, A.

    Queste lezlioni hanno come direttiva una sintesi di quanto si trova sistematicamente sviluppato in una mia Memoria sulle trasformazioni termoelastiche finite di solidi incomprimibili, in corso di stampa negli Annali di Matematica pura e applicata t. XXXIX ( 1955) pp. 147-201 , Verranno anche esposti, come necessaria premessa, alcuni d ei risultati di due precedenti Memorie degli stessi Annali. Invece, per motivo di brevità, non potrò dare neppure un cenno delle ulteriori ricerche svilup pate dal prof. T. Manacorda in tre recentissimi suoi lavori:

  15. Italian biophysics and SIBPA speed-up the pace towards the long and winding road of the interdisciplinary science.

    PubMed

    Giacomazza, Daniela; Musio, Carlo

    2016-01-01

    This Special Issue of Biophysical Chemistry presents a selection of the contributions presented at the XXII National Congress of the Italian Society of Pure and Applied Biophysics (i.e., SIBPA, Società Italiana di Biofisica Pura ed Applicata) held on September 2014 in Palermo, Italy. Topics cover all biophysical disciplines, from molecular to cellular, to integrative biophysics giving a comprehensive view of the inter- and multi-disciplinary approach of modern biophysics. SIBPA, which turned 40 in 2013, continues to grow and attract interest.

  16. Biophysical science in Italy: SIBPA turns 40.

    PubMed

    Giacomazza, Daniela; Musio, Carlo

    2013-12-01

    This Special Issue of Biophysical Chemistry includes a selection of the papers presented at the XXI Congress of the Italian Society of Pure and Applied Biophysics (i.e., SIBPA, Società Italiana di Biofisica Pura ed Applicata) held on September 2012 at the University of Ferrara, Ferrara, Italy. Topics cover all biophysical disciplines, from molecular to cellular, to integrative biophysics giving an almost comprehensive view of the interdisciplinary and multidisciplinary approaches, proper of the modern biophysics. SIBPA, which celebrates its 40th anniversary in 2013, has steadily grown and appeals to both specialists and a wider general audience.

  17. In vivo wound healing activity of Dragon's Blood (Croton spp.), a traditional South American drug, and its constituents.

    PubMed

    Pieters, L; De Bruyne, T; Van Poel, B; Vingerhoets, R; Totté, J; Vanden Berghe, D; Vlietinck, A

    1995-07-01

    The wound healing activity of dragon'sblood (Croton spp.), in Spanish 'sangre de drago‛ or 'sangre de grado‛, a traditional South American drug, and some of its constituents, including the alkaloid taspine (1), the dihydrobenzufuran lignan 3',4-O-dimethylcedrusin (2) and proantho-cyanidins, was evaluated in vivo on rats, and compared with the wound healing actitivy of synthetic proanthocyanidins. The beneficial effect of dragon's blood on wound healing was confirmed. Dragon's blood stimulated contraction of the wound, formation of a crust, formation of new collagen, and regeneration of the epithelial layer. 3',4-O-Dimethylcedrusin also improved wound healing in vivo by stimulating the formation of fibroblasts and collagen, but crude dragon's blood was more effective. This was due to the proanthocyanidins, present in dragon's blood, which stimulate contraction of the wound and precipitate with proteins forming a dark crust covering the wound, but which delay wound repair by a decreased formation of new fibroblasts.

  18. Investigation of Microphysical Parameters within Winter and Summer Type Precipitation Events over Mountainous [Complex] Terrain

    SciTech Connect

    Stalker, James R.; Bossert, James E.

    1997-12-31

    In this study we investigate complex terrain effects on precipitation with RAMS for both in winter and summer cases from a microphysical perspective. We consider a two dimensional east-west topographic cross section in New Mexico representative of the Jemez mountains on the west and the Sangre de Cristo mountains on the east. Located between these two ranges is the Rio Grande Valley. In these two dimensional experiments, variations in DSDs are considered to simulate total precipitation that closely duplicate observed precipitation.

  19. Preliminary Geologic Map of the Vermejo Peak area, Colfax and Taos Counties, New Mexico and Las Animas and Costilla Counties, Colorado

    USGS Publications Warehouse

    Fridrich, Christopher J.; Shroba, Ralph R.; Pillmore, Charles L.; Hudson, Adam M.

    2009-01-01

    This geologic map covers four 7.5-minute quadrangles-The Wall, NM-CO (New Mexico-Colorado), Vermejo Park, NM-CO, Ash Mountain, NM, and Van Bremmer Park, NM. The study area straddles the boundary between the eastern flank of the Sangre de Cristo Mountains and the western margin of the Raton Basin, with about two-thirds of the map area in the basin. The Raton Basin is a foreland basin that formed immediately eastward of the Sangre de Cristo Mountains during their initial uplift, in the Late Cretaceous through early Eocene Laramide orogeny. Subsequently, these mountains have been extensively modified during formation of the Rio Grande rift, from late Oligocene to present. The map area is within that part of the Sangre de Cristo Mountains that is called the Culebra Range. Additionally, the map covers small parts of the Devil's Park graben and the Valle Vidal half-graben, in the northwestern and southwestern parts of the map area, respectively. These two grabens are small intermontaine basins, that are satellitic to the main local basin of the Rio Grande rift, the San Luis Basin, that are an outlying, early- formed part of the rift, and that separate the Culebra Range from the Taos Range, to the southwest.

  20. Interaction of Bacillus subtilis purine repressor with DNA.

    PubMed

    Shin, B S; Stein, A; Zalkin, H

    1997-12-01

    A purine repressor (PurR) mediates adenine nucleotide-dependent regulation of transcription initiation of the Bacillus subtilis pur operon. This repressor has been purified for the first time, and binding to control site DNA was characterized. PurR binds in vitro to four operons. Apparent Kd values for binding were 7 nM for the pur operon, 8 nM for purA, 13 nM for purR, and 44 nM for the pyr operon. In each case, DNase I footprints exhibited a pattern of protected and hypersensitive sites that extended over more than 60 bp. A GAAC-N24-GTTC sequence in the pur operon was necessary but not sufficient for the PurR-DNA interaction. However, this motif, which is conserved in the four binding sites, was not required for binding of PurR to purA. Thus, the common DNA recognition element for binding of PurR to the four operons is not known. Multiple PurR-pur operon DNA complexes having a binding stoichiometry that was either approximately two or six repressor molecules per DNA fragment were detected. The results of a torsional constraint experiment suggest that control site DNA forms one right-handed turn around PurR.

  1. Directed evolution of adenylosuccinate synthetase from Bacillus subtilis and its application in metabolic engineering.

    PubMed

    Wang, Xiaoyue; Wang, Guanglu; Li, Xinli; Fu, Jing; Chen, Tao; Wang, Zhiwen; Zhao, Xueming

    2016-08-10

    Adenylosuccinate synthetase (EC. 6.3.4.4) encoded by purA in Bacillus subtilis, catalyzing the first step of the conversion of IMP to AMP, plays an important role in flux distribution in the purine biosynthetic pathway. In this study, we described the use of site saturation mutagenesis to obtain a desired enzyme activity of adenylosuccinate synthetase and its application in flux regulation. Based on sequence alignment and structural modeling, a library of enzyme variants was created by a semi-rational evolution strategy in position Thr238 and Pro242. Other than purA deletion, the leaky mutation purA(P242N) partially reduced the flux towards AMP derived from IMP and increased the riboflavin synthesis precursor GTP, while also kept the requirement of ATP synthesis for cell growth. PurA(P242N) was introduced into an inosine-producing strain and resulted in an approximately 4.66-fold increase in inosine production, from 0.088±0.009g/L to 0.41±0.051g/L, in minimal medium without hypoxanthine accumulation. These results underline that the directed evolution of adenylosuccinate synthetase could tailor its activities and adjust metabolic flux. This mutation may provide a promising application in purine-based product accumulation, like inosine, guanosine and folate which are directly stemming from purine pathway in B. subtilis. PMID:27234879

  2. Semaphorin 3C Released from a Biocompatible Hydrogel Guides and Promotes Axonal Growth of Rodent and Human Dopaminergic Neurons.

    PubMed

    Carballo-Molina, Oscar A; Sánchez-Navarro, Andrea; López-Ornelas, Adolfo; Lara-Rodarte, Rolando; Salazar, Patricia; Campos-Romo, Aurelio; Ramos-Mejía, Verónica; Velasco, Iván

    2016-06-01

    Cell therapy in experimental models of Parkinson's disease replaces the lost dopamine neurons (DAN), but we still need improved methods to guide dopaminergic axons (DAx) of grafted neurons to make proper connections. The protein Semaphorin 3C (Sema3C) attracts DAN axons and enhances their growth. In this work, we show that the hydrogel PuraMatrix, a self-assembling peptide-based matrix, incorporates Sema3C and releases it steadily during 4 weeks. We also tested if hydrogel-delivered Sema3C attracts DAx using a system of rat midbrain explants embedded in collagen gels. We show that Sema3C released by this hydrogel attracts DAx, in a similar way to pretectum, which is known to attract growing DAN axons. We assessed the effect of Sema3C on the growth of DAx using microfluidic devices. DAN from rat midbrain or those differentiated from human embryonic stem cells showed enhanced axonal extension when exposed to hydrogel-released Sema3C, similar to soluble Sema3C. Notably, DAN of human origin express the cognate Sema3C receptors, Neuropilin1 and Neuropilin2. These results show that PuraMatrix is able to incorporate and release Sema3C, and such delivery guides and promotes the axonal growth of DAN. This biocompatible hydrogel might be useful as a Sema3C carrier for in vivo studies in parkinsonian animal models. PMID:27174503

  3. Semaphorin 3C Released from a Biocompatible Hydrogel Guides and Promotes Axonal Growth of Rodent and Human Dopaminergic Neurons

    PubMed Central

    Carballo-Molina, Oscar A.; Sánchez-Navarro, Andrea; López-Ornelas, Adolfo; Lara-Rodarte, Rolando; Salazar, Patricia; Campos-Romo, Aurelio; Ramos-Mejía, Verónica

    2016-01-01

    Cell therapy in experimental models of Parkinson's disease replaces the lost dopamine neurons (DAN), but we still need improved methods to guide dopaminergic axons (DAx) of grafted neurons to make proper connections. The protein Semaphorin 3C (Sema3C) attracts DAN axons and enhances their growth. In this work, we show that the hydrogel PuraMatrix, a self-assembling peptide-based matrix, incorporates Sema3C and releases it steadily during 4 weeks. We also tested if hydrogel-delivered Sema3C attracts DAx using a system of rat midbrain explants embedded in collagen gels. We show that Sema3C released by this hydrogel attracts DAx, in a similar way to pretectum, which is known to attract growing DAN axons. We assessed the effect of Sema3C on the growth of DAx using microfluidic devices. DAN from rat midbrain or those differentiated from human embryonic stem cells showed enhanced axonal extension when exposed to hydrogel-released Sema3C, similar to soluble Sema3C. Notably, DAN of human origin express the cognate Sema3C receptors, Neuropilin1 and Neuropilin2. These results show that PuraMatrix is able to incorporate and release Sema3C, and such delivery guides and promotes the axonal growth of DAN. This biocompatible hydrogel might be useful as a Sema3C carrier for in vivo studies in parkinsonian animal models. PMID:27174503

  4. Blood lipid profile and glucose of university students (China).

    PubMed

    Liang, Wei; Wang, Linghong; Guo, Daoxia; Nie, Zhognhua; Chen, Yan; Jin, Yuelong; He, Lianping; Yao, Yingshui

    2015-05-01

    Objetivo: El objetivo principal de este estudio fue estimar la glucosa de la sangre y el perfil lípido de la sangre de estudio en una universidad en China. Métodos: Estudio descriptivo basado en la revision de salud; datos para estudiantes universitarios en 2013. La glucosa en la sangre (GLU), perfiles de lípidos (colesterol total (CT), triglicéridos (Tg) y lipoproteína de alta densidad (HDL - c) se midió utilizando Hitachi modelo 747 Analizador automático. Los valores de colesterol LDL se calculan según la fórmula: C - LDL HDL - C = TC Ching Ching TG / 5. Resultados: La media de HDL fueron 51,31 y 56.30 mg / dl para varón y mujer, respectivamente (p < 0,05) y LDL (p < 0.05). La mayoría de los estudiantes tienen nivel normal de Glu (65-110mgl / dl). TC y LDL elevados fueron observados en 6.92% y el 5,82% de varones, asimismo, 5,91% y el 3,57% de mujeres. Altos niveles de TC, LDL y TG fueron detectados en estudiantes universitarios masculinos; 1.02% 0,71% y un 1,41%, respectivamente; en mujeres estudiantes de la Universidad were1.26%, 1.04 y 0,68%, respectivamente. La reducción de los niveles de HDL fueron observados en 5.59% de hombres y el 2,62% de mujeres. Conclusión: El estudio demostró que la prevalencia de la glucosa de la sangre y de lípidos en sangre en los estudiantes universitarios, especialmente la reducción de los niveles de HDL y LDL elevados de TC y en estudiantes universitarios, se ha convertido en un problema de salud crítico. Colegios, escuelas y el Gobierno deben prestar más atención a la salud física de los estudiantes.

  5. Oil Bypass Filter Technology Evaluation Ninth Quarterly Report October–December 2004

    SciTech Connect

    Larry Zirker; James Francfort; Jordan Fielding

    2005-02-01

    This Oil Bypass Filter Technology Evaluation quarterly report (October–December 2004) details the ongoing fleet evaluation of oil bypass filter technologies being conducted by the Idaho National Laboratory (INL; formerly Idaho National Engineering and Environmental Laboratory) for the U.S. Department of Energy’s FreedomCAR & Vehicle Technologies Program. Eight INL four-cycle diesel-engine buses used to transport INL employees on various routes and six INL Chevrolet Tahoes with gasoline engines are equipped with oil bypass filter systems from the puraDYN Corporation. This quarter, three additional buses were equipped with bypass filters from Refined Global Solutions. Oil bypass filters are reported to have an engine oil filtering capability of less than 1 micron. Both the puraDYN and Refined Global Solutions bypass filters have a heating chamber to remove liquid contaminate from the oil. During the quarter, the eleven diesel engine buses traveled 62,188 miles, and as of January 3, 2005 the buses had accumulated 643,036 total test miles. Two buses had their engine oil changed this quarter. In one bus, the oil was changed due to its degraded quality as determined by a low total base number (<3.0 mg KOH/g). The other bus had high oxidation and nitration numbers (>30.0 Abs/cm). Although a total of six buses have had their oil changed during the last 26 months, by using the oil bypass filters the buses in the evaluation avoided 48 oil changes, which equates to 1,680 quarts (420 gallons) of new oil not consumed and 1,680 quarts of waste oil not generated. Therefore, over 80% of the oil normally required for oil-changes was not used, and, consequently, the evaluation achieved over 80% reduction in the amount of waste oil normally generated. The six Tahoe test vehicles traveled 39,514 miles, and as of January 3, 2005 the Tahoes had accumulated 189,970 total test miles. The Tahoe filter test is in transition. To increase the rate of bypass filter oil flow on the Tahoes

  6. Uptake and phytotoxicity of the herbicide metsulfuron methyl in corn root tissue in the presence of the safener 1,8-naphthalic anhydride. [Zea mays L

    SciTech Connect

    Milhomme, H.; Bastide, J. )

    1990-06-01

    Growth of Zea mays L. cv Potro roots was inhibited by the herbicide metsulfuron methyl (MSM) at the lowest concentration tested: 5 nanomoles per liter. Pretreatment of corn seeds with commercial 1,8-naphthalic anhydride (NA) at 1% (w/w) partially reversed MSM-induced root growth inhibition. MSM at a concentration of 52 nanomoles per liter was taken up rapidly by roots and accumulated in the corn tissue to concentrations three times those in the external medium; the safener NA increased MSM uptake up to 48 hours. The protective effect of NA was related to the ability of the safener to increase the metabolism of MSM; ten-fold increases in the metabolic rates of MSM were observed in NA-pretreated corn seedlings grown for 48 hours on 52 nanomolar ({sup 14}C)MSM solution. DNA synthesis determined by measurement of ({sup 3}H)thymidine incorporation into DNA was inhibited by root MSM applications; after a 6-hour application period, 13 nanomolar MSM solution reduced DNA synthesis by 64%, and the same reduction was also observed with NA-treated seedlings. Pretreatment of corn seeds with safener NA did not increase the acetolactate synthase activity in the roots and did not change, up to 13 micromoles per liter, the in vitro sensitivity of roots to MSM.

  7. [Isolated bacteria from nasal cultures. Are they important in patients with acute leukemia?].

    PubMed

    Barranco-Lampón, Gilberto; Mendoza-García, Carlos Alberto; Cabrera-Osuna, Silvia; Olarte-Carrillo, Irma; Ventura, Yanet; Gutiérrez-Romero, Mario; Martínez-Murillo, Carlos; Martínez-Tovar, Adolfos; Ramos-Peñafiel, Christian Omar

    2014-01-01

    INTRODUCCIÓN: la colonización nasal por Staphylcoccus epidermidis y Staphylococcus aureus es frecuente y se ha relacionado con bacteremia en huéspedes inmunocomprometidos. En la investigación que se presenta, los objetivos fueron determinar la frecuencia de cepas que colonizan la mucosa nasal en pacientes en tratamiento de leucemia aguda y su relación con los cultivos de sangre periférica. MÉTODOS: estudio retrospectivo, observacional, transversal, retrolectivo de cultivos nasales obtenidos durante cuatro semanas. La relación con los hemocultivos se estableció mediante chi cuadrada; se calculó razón de momios.

  8. The use of strontium-87/strontium-86 ratios to measure atmospheric transport into forested watersheds.

    PubMed

    Graustein, W C; Armstrong, R L

    1983-01-21

    Strontium-87/strontium-86 ratios indicate the sources of strontium in samples of natural waters, vegetation, and soil material taken from watersheds in the Sangre de Cristo Mountains of New Mexico. More than 75 percent of the strontium in the vegetation is ultimately derived from atmospheric transport and less than 25 percent from the weathering of the underlying rock. Much of the airborne strontium enters the watersheds by impacting on coniferous foliage, but deciduous foliage apparently traps little, if any, strontium-bearing aerosol. The strontium and presumably other nutrients are continuously recycled in a nearly closed system consisting of upper soil horizons, forest litter, and the standing crop of vegetation.

  9. Autoregulation of PurR repressor synthesis and involvement of purR in the regulation of purB, purC, purL, purMN and guaBA expression in Escherichia coli.

    PubMed

    Meng, L M; Kilstrup, M; Nygaard, P

    1990-01-26

    The purR gene encodes a repressor (PurR) controlling the synthesis of the enzymes of purine biosynthesis. The subunit of PurR was identified as a 38-kDa polypeptide by SDS/polyacrylamide gel electrophoresis. Analysis of a purR-lacZ transcriptional fusion indicated that purR expression is autoregulated. This was confirmed by gel retardation and DNaseI footprinting experiments, where two PurR-binding sites were identified in the transcribed part of purR. Introduction of a purR mutation in wild-type and pur-lac fusion strains was found to abolish purine repression of all genes of the purine biosynthetic pathway except for purA.

  10. Four new bioluminescent taxa of Mycena sect. Calodontes from Peninsular Malaysia.

    PubMed

    Chew, Audrey L C; Tan, Yee-Shin; Desjardin, Dennis E; Musa, Md Yusoff; Sabaratnam, Vikineswary

    2014-01-01

    Three new species and one new variety of bioluminescent Mycena collected from Peninsular Malaysia are described herein. All new species belong to Mycena sect. Calodontes in what is known as the Mycena pura complex. Comprehensive descriptions, photographs, illustrations and comparisons with phenetically similar species are provided. Molecular sequences data from the nuclear internal transcribed spacers (ITS-1 and ITS-2, including the 5.8S rRNA) were used to infer relationships within sect. Calodontes. Axenic cultures were obtained to provide data on culture morphology. This is the first published photographic documentation of bioluminescent basidiomes of members of Mycena sect. Calodontes. Also, this addition brings the total known bioluminescent fungi to 77 species.

  11. Oil Bypass Filter Technology Performance Evaluation - First Quarterly Report

    SciTech Connect

    Zirker, L.R.; Francfort, J.E.

    2003-01-31

    This report details the initial activities to evaluate the performance of the oil bypass filter technology being tested by the Idaho National Engineering and Environmental Laboratory (INEEL) for the U.S. Department of Energy's FreedomCAR & Vehicle Technologies Program. Eight full-size, four-cycle diesel-engine buses used to transport INEEL employees on various routes have been equipped with oil bypass systems from the puraDYN Corporation. Each bus averages about 60,000 miles a year. The evaluation includes an oil analysis regime to monitor the presence of necessary additives in the oil and to detect undesirable contaminants. Very preliminary economic analysis suggests that the oil bypass system can reduce life-cycle costs. As the evaluation continues and oil avoidance costs are quantified, it is estimated that the bypass system economics may prove increasingly favorable, given the anticipated savings in operational costs and in reduced use of oil and waste oil avoidance.

  12. Holocene malacofauna in calcareous deposits of Dūkšta site near Maišiagala in Lithuania

    NASA Astrophysics Data System (ADS)

    Sanko, Aleksander; Gaigalas, Algirdas; Rudnickaitė, Eugenija; Melešytė, Monika

    2008-01-01

    The paper contains results of new investigations in Lithuania of the first occurrences of terrestrial molluscs in calcareous tufa (travertine), carbonate content and radiocarbon dating. Terrestrial fossil molluscs (35 taxa) prevail in the mollusc fauna, while freshwater species are much more rare (6 taxa). The Dūkšta terrestrial mollusc fauna embraces a complex of thermophiles including such forest species as Acicula polita (Hartmann), Acanthinula aculeata (Müller), Aegopinella cf. pura (Alder), Bulgaria cana (Held) and Discus cf. rotundatus (Müller), as well as mainly South European Carychium tridentatum (Risso) and mainly West European Vertigo moulinsiana (Dupuy). The radiocarbon age of the sediments was found to correspond to the end of the Atlantic climatic period and the beginning of the Subboreal.

  13. User's guide to SERICPAC: A computer program for calculating electric-utility avoided costs rates

    SciTech Connect

    Wirtshafter, R.; Abrash, M.; Koved, M.; Feldman, S.

    1982-05-01

    SERICPAC is a computer program developed to calculate average avoided cost rates for decentralized power producers and cogenerators that sell electricity to electric utilities. SERICPAC works in tandem with SERICOST, a program to calculate avoided costs, and determines the appropriate rates for buying and selling of electricity from electric utilities to qualifying facilities (QF) as stipulated under Section 210 of PURA. SERICPAC contains simulation models for eight technologies including wind, hydro, biogas, and cogeneration. The simulations are converted in a diversified utility production which can be either gross production or net production, which accounts for an internal electricity usage by the QF. The program allows for adjustments to the production to be made for scheduled and forced outages. The final output of the model is a technology-specific average annual rate. The report contains a description of the technologies and the simulations as well as complete user's guide to SERICPAC.

  14. Oil Bypass Filter Technology Performance Evaluation - January 2003 Quarterly Report

    SciTech Connect

    Laurence R. Zirker; James E. Francfort

    2003-01-01

    This report details the initial activities to evaluate the performance of the oil bypass filter technology being tested by the Idaho National Engineering and Environmental Laboratory (INEEL) for the U.S. Department of Energy's FreedomCAR & Vehicle Technologies Program. Eight full-size, four-cycle diesel-engine buses used to transport INEEL employees on various routes have been equipped with oil bypass systems from the puraDYN Corporation. Each bus averages about 60,000 miles a year. The evaluation includes an oil analysis regime to monitor the presence of necessary additives in the oil and to detect undesirable contaminants. Very preliminary economic analysis suggests that the oil bypass system can reduce life-cycle costs. As the evaluation continues and oil avoidance costs are quantified, it is estimated that the bypass system economics may prove increasingly favorable, given the anticipated savings in operational costs and in reduced use of oil and waste oil avoidance.

  15. Investigation of various genotype characteristics for inosine accumulation in Escherichia coli W3110.

    PubMed

    Matsui, H; Kawasaki, H; Shimaoka, M; Kurahashi, O

    2001-03-01

    For the derivation of an inosine-overproducing strain from the wild type microorganism, it is known that the addition of an adenine requirement, removal of purine nucleoside hydrolyzing activity, removal of the feedback inhibition, and repression of key enzymes in the purine nucleotides biosynthetic pathway are essential. Thus, the disruption of purA (adenine requirement), deoD (removal of purine nucleosides phosphorylase activity), purR (derepression of the regulation of purine nucleotides biosynthetic pathway), and the insensitivity of the feedback inhibition of phosphoribosylpyrophosphate (PRPP) amidotransferase by adenosine 5'-monophosphate (AMP) and guanosine 5'-monophosphate (GMP) were done in the Escherichia coli strain W3110, and then the inosine productivity was estimated. In the case of using a plasmid harboring the PRPP amidotransferase gene (purF) that encoded a desensitized PRPP amidotransferase, purF disrupted mutants were used as the host strains. It was found that the innovation of the four genotypes brought about a small amount of inosine accumulation. Furthermore, an adenine auxotrophic mutant of E. coli showed inappropriate adenine use because its growth could not respond efficiently to the concentration of adenine added. As the presence of adenosine deaminase is well known in E. coli and it is thought to be involved in adenine use, a mutant disrupted adenosine deaminase gene (add) was constructed and tested. The mutant, which is deficient in purF, purA, deoD, purR, and add genes, and harboring the desensitized purF as a plasmid, accumulated about 1 g of inosine per liter. Although we investigated the effects of purR disruption and purF gene improvement, unexpectedly an increase in the inosine productivity could not be found with this mutant.

  16. Comparative Genomics Reveals Biomarkers to Identify Lactobacillus Species.

    PubMed

    Koul, Shikha; Kalia, Vipin Chandra

    2016-09-01

    Bacteria possessing multiple copies of 16S rRNA (rrs) gene demonstrate high intragenomic heterogeneity. It hinders clear distinction at species level and even leads to overestimation of the bacterial diversity. Fifty completely sequenced genomes belonging to 19 species of Lactobacillus species were found to possess 4-9 copies of rrs each. Multiple sequence alignment of 268 rrs genes from all the 19 species could be classified into 20 groups. Lactobacillus sanfranciscensis TMW 1.1304 was the only species where all the 7 copies of rrs were exactly similar and thus formed a distinct group. In order to circumvent the problem of high heterogeneity arising due to multiple copies of rrs, 19 additional genes (732-3645 nucleotides in size) common to Lactobacillus genomes, were selected and digested with 10 Type II restriction endonucleases (RE), under in silico conditions. The following unique gene-RE combinations: recA (1098 nts)-HpyCH4 V, CviAII, BfuCI and RsaI were found to be useful in identifying 29 strains representing 17 species. Digestion patterns of genes-ruvB (1020 nts), dnaA (1368 nts), purA (1290 nts), dnaJ (1140 nts), and gyrB (1944 nts) in combination with REs-AluI, BfuCI, CviAI, Taq1, and Tru9I allowed clear identification of an additional 14 strains belonging to 8 species. Digestion pattern of genes recA, ruvB, dnaA, purA, dnaJ and gyrB can be used as biomarkers for identifying different species of Lactobacillus. PMID:27407290

  17. Purine Salvage Pathways among Borrelia Species▿

    PubMed Central

    Pettersson, Jonas; Schrumpf, Merry E.; Raffel, Sandra J.; Porcella, Stephen F.; Guyard, Cyril; Lawrence, Kevin; Gherardini, Frank C.; Schwan, Tom G.

    2007-01-01

    Genome sequencing projects on two relapsing fever spirochetes, Borrelia hermsii and Borrelia turicatae, revealed differences in genes involved in purine metabolism and salvage compared to those in the Lyme disease spirochete Borrelia burgdorferi. The relapsing fever spirochetes contained six open reading frames that are absent from the B. burgdorferi genome. These genes included those for hypoxanthine-guanine phosphoribosyltransferase (hpt), adenylosuccinate synthase (purA), adenylosuccinate lyase (purB), auxiliary protein (nrdI), the ribonucleotide-diphosphate reductase alpha subunit (nrdE), and the ribonucleotide-diphosphate reductase beta subunit (nrdF). Southern blot assays with multiple Borrelia species and isolates confirmed the presence of these genes in the relapsing fever group of spirochetes but not in B. burgdorferi and related species. TaqMan real-time reverse transcription-PCR demonstrated that the chromosomal genes (hpt, purA, and purB) were transcribed in vitro and in mice. Phosphoribosyltransferase assays revealed that, in general, B. hermsii exhibited significantly higher activity than did the B. burgdorferi cell lysate, and enzymatic activity was observed with adenine, hypoxanthine, and guanine as substrates. B. burgdorferi showed low but detectable phosphoribosyltransferase activity with hypoxanthine even though the genome lacks a discernible ortholog to the hpt gene in the relapsing fever spirochetes. B. hermsii incorporated radiolabeled hypoxanthine into RNA and DNA to a much greater extent than did B. burgdorferi. This complete pathway for purine salvage in the relapsing fever spirochetes may contribute, in part, to these spirochetes achieving high cell densities in blood. PMID:17502392

  18. [Therapeutic potential of bone marrow stem cells in cerebral infarction].

    PubMed

    Sánchez-Cruz, Gilberto; Milián-Rodríguez, Lismary

    2015-05-16

    Introduccion. Las celulas madre constituyen una alternativa terapeutica que se encuentra en fase de experimentacion para el infarto cerebral. Objetivo. Mostrar la evidencia cientifica existente sobre el potencial terapeutico de las celulas madre de la medula osea en esta enfermedad. Desarrollo. El infarto cerebral representa el 80% de las enfermedades cerebrovasculares. La trombolisis constituye la unica terapia aprobada, pero, por su estrecha ventana terapeutica, solo se aplica a un bajo porcentaje de los pacientes. De manera alternativa, los tratamientos neurorrestauradores, como el de celulas madre, pueden aplicarse en periodos mas prolongados. Por esta razon se efectuo una busqueda bibliografica en PubMed con el empleo de las palabras clave 'stem cells', 'bone marrow derived mononuclear cells' y 'stroke'. Se encontraron evidencias de seguridad y eficacia de dichas celulas en diferentes momentos evolutivos del infarto cerebral. Se identificaron estudios que en clinica y preclinica las recolectaron por puncion medular y en sangre periferica, y las trasplantaron directamente en el area infartada o por via intravascular. El efecto terapeutico se relaciona con sus propiedades de plasticidad celular y liberacion de factores troficos. Conclusiones. El concentrado de celulas mononucleares autologas, obtenido en sangre periferica o por puncion de la medula osea, y trasplantado por via intravenosa, es una factible opcion metodologica que permitira rapidamente incrementar el numero de ensayos clinicos en diferentes etapas evolutivas del infarto cerebral. Esta terapia muestra seguridad y eficacia; sin embargo, deben ampliarse las evidencias que avalen su generalizacion en humanos.

  19. Significant cenozoic faulting, east margin of the Espanola basin, Rio Grande Rift, New Mexico

    SciTech Connect

    Vernon, J.H. ); Riecker, R.E.

    1989-03-01

    Tectonic interpretation of the east margin of the Espanola Basin, Rio Grande rift, New Mexico, has been controversial. Previous authors have disagreed as to whether significant faulting defines the boundary between the basin and the Sangre de Cristo Mountains. A more recent geophysical basin transect that suggests no significant faulting and field observation of faceted spurs along the western Sangre de Cristo Mountain front indicating a faulted margin motivate our study. The east margin of the Espanola Basin for about 37 km north of Santa Fe, New Mexico, is marked by a complex array of significant, late Cenozoic high-angle faults. Locally, three parallel, north-trending, high-angle faults cut Precambrian basement and Tertiary basin-full rocks along the basin margin. Elsewhere along the margin, tilted fault blocks and intersecting faults occur. Fault area, fault attitude with depth, magnitude of fault motion, and timing of fault motion remain uncertain. However, faults studied in detail are 1-2 km long, have minimum dip-slip motion of 33-100 m, and underwent movement during the late Cenozoic. Potentially significant tectonic and seismic hazard implications arise from the possibility of post-150 ka fault motion.

  20. Constraints on the age of the Great Sand Dunes, Colorado, from subsurface stratigraphy and OSL dates

    USGS Publications Warehouse

    Madole, Richard F.; Mahan, Shannon; Romig, Joe H.; Havens, Jeremy C.

    2013-01-01

    The age of the Great Sand Dunes has been debated for nearly 150 yr. Seven ages ranging from Miocene to late Holocene have been proposed for them. This paper presents new information—chiefly subsurface stratigraphic data, OSL dates, and geomorphic evidence—that indicates that the Great Sand Dunes began to form in the latter part of the middle Pleistocene. The dunes overlie a thick wedge of piedmont-slope deposits, which in turn overlies sediment of Lake Alamosa, a paleolake that began to drain about 440 ka. The wedge of piedmont-slope deposits extends westward for at least 23 km and is as much as 60 m thick at a distance of 10 km from the Sangre de Cristo Range. Ostracodes from one well indicate that the eastern shoreline of Lake Alamosa extended to within 4.3 km of where the Great Sand Dunes eventually formed. The time represented by the wedge of piedmont-slope deposits is not known exactly, but the wedge post-dates 440 ka and was in place prior to 130 ka because by then the dunes overlying it were sufficiently close and tall enough to obstruct streams draining from the Sangre de Cristo Range.

  1. Uranium-bearing copper deposits in the Coyote district, Mora County, New Mexico

    USGS Publications Warehouse

    Zeller, H.D.; Baltz, Elmer Harold

    1954-01-01

    Uranium-bearing copper deposits occur in steeply dipping beds of the Sangre de Cristo formation of Pennsylvanian and Permian(?) age south of Coyote, Mora County, N. Mex. Mapping and sampling of these deposits indicate that they are found in lenticular carbonaceous zones in shales and arkosic sandstones. Samples from these zones contain as much as 0.067 percent uranium and average 3 percent copper. Metatyuyamunite is dissemihatedin some of the arkosic sandstone beds, and uraninite is present in some of the copper sulfide nodules occurring in the shale. These sulfide nodules are composed principally of chalcocite but include some bornite, covellite, pyrite, and malachite. Most of the samples were collected near the surface from the weathered zone. The copper and uranium were probably deposited with the sediments and concentrated into zones during compaction and lithification. Carbonaceous material in the Sangre de Cristo formation provided the environment that precipitated uranium and copper from mineral-charged connate waters forced from the clayey sediments.

  2. Revised Geologic Map of the Fort Garland Quadrangle, Costilla County, Colorado

    USGS Publications Warehouse

    Wallace, Alan R.; Machette, Michael N.

    2008-01-01

    The map area includes Fort Garland, Colo., and the surrounding area, which is primarily rural. Fort Garland was established in 1858 to protect settlers in the San Luis Valley, then part of the Territory of New Mexico. East of the town are the Garland mesas (basalt-covered tablelands), which are uplifted as horsts with the Central Sangre de Cristo fault zone. The map also includes the northern part of the Culebra graben, a deep structural basin that extends from south of San Luis (as the Sanchez graben) to near Blanca, about 8 km west of Fort Garland. The oldest rocks exposed in the map area are early Proterozic basement rocks (granites in Ikes Creek block) that occupy an intermediate structural position between the strongly uplifted Blanca Peak block and the Culebra graben. The basement rocks are overlain by Oligocene volcanic and volcaniclastic rocks of unknown origin. The volcanic rocks were buried by a thick sequence of basin-fill deposits of the Santa Fe Group as the Rio Grande rift formed about 25 million years ago. The Servilleta Basalt, a regional series of 3.7?4.8 Ma old flood basalts, was deposited within sediment, and locally provides a basis for dividing the group into upper and lower parts. Landslide deposits and colluvium that rest on sediments of the Santa Fe Group cover the steep margins of the mesas. Exposures of the sediment beneath the basalt and within the low foothills east of the Central Sangre de Cristo fault zone are comprised of siltstones, sandstones, and minor fluvial conglomerates. Most of the low ground surrounding the mesas and in the graben is covered by surficial deposits of Quaternary age. The alluvial deposits are subdivided into three Pleistocene-age units and three Holocene-age units. The oldest Pleistocene gravel (unit Qao) is preserved as isolated remnants that cap high surfaces north and east of Fort Garland. The primary geologic hazards in the map area are from earthquakes, landslides, and localized flooding. The Central

  3. [B lymphocyte stimulator (BLyS/BAFF) level in sera of patients with lupus].

    PubMed

    Mercado, Ulises; Díaz-Molina, Raúl

    2016-01-01

    Introducción: el estimulador de linfocitos B (BLyS/BAFF) es una proteína endógena fundamental en la diferenciación y la maduración de linfocitos B. En el lupus se han encontrado niveles altos de BLyS. Métodos: se analizaron muestras séricas de 92 pacientes con lupus (94 % mujeres, con una mediana de edad de 35.5) y 106 controles (50 donadores de sangre, 38 pacientes con artritis reumatoide y 18 pacientes con esclerodermia). El punto de corte de BLyS ˃ 1.98 ng/mL corresponde al percentil 95 de los 50 donadores de sangre. También se evaluaron anticuerpos contra ADN nativo y actividad de enfermedad. Durante el seguimiento, los niveles de BLyS en 32 pacientes mostraron heterogeneidad. Resultados: la mediana de BLyS en 92 pacientes con lupus fue de 1.9 ng/mL (rango 0.4-5.3), comparada con 1.30, 1.35, y 1.35 ng/mL en donadores de sangre, pacientes con artritis reumatoide y pacientes con esclerodermia, respectivamente. Treinta y nueve pacientes con lupus tuvieron niveles elevados de BLyS (mediana 2.8 ng/mL), comparados con el grupo control. Hubo una moderada correlación entre títulos de anti-ADN (r = 0.34) y actividad de enfermedad (0.45). El seguimiento de 32 pacientes mostró un nivel de BLyS persistentemente elevado, normal o con variaciones intermitentes. Conclusión: el nivel de BLyS resultó elevado en algunos pacientes con lupus. Hubo una moderada correlación con títulos de anti-ADN y actividad de enfermedad. El seguimiento de 32 pacientes mostró fluctuaciones en los niveles de BLyS.

  4. Investigation of water quality in the Great Sand Dunes National Monument and Preserve, Saguache County, Colorado, February 1999 through September 2000: Qualifying for outstanding waters designation

    USGS Publications Warehouse

    Ferguson, Sheryl A.

    2003-01-01

    Great Sand Dunes National Monument and Preserve is located on the eastern side of the San Luis Valley in south-central Colorado. The monument covers 60.4 square miles in Saguache and Alamosa Counties and lies at the base of the Sangre de Cristo Mountains, where a unique combination of climate, topography, and hydrology has created and maintained the Nation?s tallest inland sand dunes. The Sangre de Cristo Mountains, which rise to more than 14,000 feet to the north and east of the dunes, are the source of several streams that flow around the dunes and eventually recharge the aquifer beneath the valley. Sand Creek and Medano Creeks are the largest of the streams in the monument that originate in the Sangre de Cristo Mountains; several ephemeral streams flow into Sand Creek and Medano Creek. Maintaining the high surface-water quality in the Great Sand Dunes National Monument and Preserve is identified as a critical issue by the National Park Service. Additionally, the National Park Service has indicated a desire to pursue an Outstanding Waters Designation, which offers the highest level of water-quality protection available under the Clean Water Act and Colorado regulations. This designation is designed to prevent any degradation from existing conditions (Chatman and others, 1997). Assessment is needed to evaluate whether the water quality of the streams in the monument meets the requirements for an Outstanding Waters Designation. Historically, prospecting and mining activities have occurred in the watersheds of Sand and Medano Creeks; currently, however, there is no mining activity in those watersheds. In addition, the camping and recreation that occur upstream from the monument on national preserve lands and water activities that occur in Medano Creek during the summer are a potential source of human-waste contamination. Figure 1. Location of study area, sampling sites, and indication of sites that meet or exceed instream standards. The U.S. Geological Survey (USGS

  5. Preliminary geologic map of the Big Costilla Peak area, Taos County, New Mexico, and Costilla County, Colorado

    USGS Publications Warehouse

    Fridrich, Christopher J.; Shroba, Ralph R.; Hudson, Adam M.

    2012-01-01

    This map covers the Big Costilla Peak, New Mex.&nash;Colo. quadrangle and adjacent parts of three other 7.5 minute quadrangles: Amalia, New Mex.–Colo., Latir Peak, New Mex., and Comanche Point, New Mex. The study area is in the southwesternmost part of that segment of the Sangre de Cristo Mountains known as the Culebra Range; the Taos Range segment lies to the southwest of Costilla Creek and its tributary, Comanche Creek. The map area extends over all but the northernmost part of the Big Costilla horst, a late Cenozoic uplift of Proterozoic (1.7-Ga and less than 1.4-Ga) rocks that is largely surrounded by down-faulted middle to late Cenozoic (about 40 Ma to about 1 Ma) rocks exposed at significantly lower elevations. This horst is bounded on the northwest side by the San Pedro horst and Culebra graben, on the northeast and east sides by the Devils Park graben, and on the southwest side by the (about 30 Ma to about 25 Ma) Latir volcanic field. The area of this volcanic field, at the north end of the Taos Range, has undergone significantly greater extension than the area to the north of Costilla Creek. The horsts and grabens discussed above are all peripheral structures on the eastern flank of the San Luis basin, which is the axial part of the (about 26 Ma to present) Rio Grande rift at the latitude of the map. The Raton Basin lies to the east of the Culebra segment of the Sangre de Cristo Mountains. This foreland basin formed during, and is related to, the original uplift of the Sangre de Cristo Mountains which was driven by tectonic contraction of the Laramide (about 70 Ma to about 40 Ma) orogeny. Renewed uplift and structural modification of these mountains has occurred during formation of the Rio Grande rift. Surficial deposits in the study area include alluvial, mass-movement, and glacial deposits of middle Pleistocene to Holocene age.

  6. [Expression of CD152 and CD137 on T regulatory cells in rhinitis and bronchial asthma patients].

    PubMed

    Rojas-Ramos, Enrique; Martínez-Jiménez, Norma E; Verdejo-Hernández, Billy; Vázquez, Gilberto

    2015-01-01

    Antecedentes: la rinitis alérgica y el asma bronquial son enfermedades inflamatorias cuya prevalencia ha aumentado en las últimas dos décadas. Los estudios de la respuesta inflamatoria en estas enfermedades muestran que las células T reguladoras (Treg) participan en la tolerancia inmunológica. La expresión de CTLA-4 (CD152) se asocia con la actividad funcional de esta población y la expresión de 4-1BB (CD137) tiene un papel controvertido. Objetivo: determinar la existencia de CTLA-4 y 4-1BB en las células Treg en sangre periférica de pacientes con rinitis, asma, o ambas. Material y método: estudio transversal comparativo en el que se reclutaron tres grupos de pacientes: 20 sujetos con rinitis alérgica, 17 sujetos con asma bronquial y 17 con ambos padecimientos. Se formó un grupo control de 19 sujetos sanos. Se analizó la frecuencia de células Treg en sangre periférica y la expresión de CD152 y CD137 en los diferentes grupos mediante citometría de flujo. Resultados: se encontró menor frecuencia estadísticamente significativa de células Treg (CD4+, CD25altas y FoxP3+) en los grupos de sujetos con: asma bronquial (p<0.001) y en el grupo de rinitis alérgica con asma bronquial (p<0.05) respecto del grupo de sujetos sanos. Los pacientes con asma bronquial únicamente tuvieron mayor frecuencia de células Treg que expresan CD152 (p <0.01) y CD137 (p<0.01) respecto del grupo control. Conclusiones: los sujetos con asma bronquial y rinitis alérgica y asma bronquial únicamente tienen deficiencia de Treg CD4+, CD25altas y FoxP3+ en sangre periférica y los sujetos con asma bronquial tienen mayor frecuencia de células Treg que expresan CD152 y CD137.

  7. Oil Bypass Filter Technology Evaluation Tenth Quarterly Report January–March 2005

    SciTech Connect

    Larry Ziker; James Francfort

    2005-06-01

    This Oil Bypass Filter Technology Evaluation quarterly report (January– March 2005) details the ongoing fleet evaluation of oil bypass filter technologies being conducted by the Idaho National Laboratory (INL) for the U.S. Department of Energy’s FreedomCAR & Vehicle Technologies Program. Eleven INL fourcycle diesel-engine buses and six INL Chevrolet Tahoes with gasoline engines are equipped with oil bypass filter systems. Eight of the buses and the six Tahoes are equipped with oil bypass filters from the puraDYN Corporation; the remaining three buses are equipped with oil bypass filters from Refined Global Solutions. Both the puraDYN and Refined Global Solutions bypass filters have a heating chamber to remove liquid contaminates from the oil. During the January to March 2005 reporting quarter, the eleven diesel engine buses traveled 97,943 miles. As of March 31, 2005, the buses had accumulated 744,059 total test miles. During this quarter, four regularly scheduled 12,000-mile bus servicings were performed. The full-flow and bypass oil filters were changed and oil analysis samples were taken for the four buses. Bus 73446 had its oil changed due to a low total base number value. Bus 73450 had a major engine failure at the beginning of the quarter when one of its pushrods and valves were damaged. Buses 73432 and 73433 were removed from the bypass filter evaluation project and placed into the INL Diesel Engine Idling Wear-Rate Evaluation Test. While a total of nine oil changes on the INL buses occurred during the past 29 months, 53 oil changes have been avoided by using the oil bypass filters. The 53 avoided oil changes equates to 1,855 quarts (464 gallons) of new oil not consumed and 1,855 quarts of waste oil not generated. Therefore, over 85% of the oil normally required for oil-changes was not used, and, consequently, the evaluation achieved a greater than 85% reduction in the amount of waste oil normally generated by the buses. The six Tahoe test vehicles

  8. Uma grade de perfis teóricos para estrelas massivas em transição

    NASA Astrophysics Data System (ADS)

    Nascimento, C. M. P.; Machado, M. A.

    2003-08-01

    Na XXVIII Reunião Anual da Sociedade Astronômica Brasileira (2002) apresentamos uma grade de perfis calculados de acordo com os pontos da trajetória evolutiva de metalicidade solar, Z = 0.02 e taxa de perda de massa () padrão, para estrelas com massa inicial de 25, 40, 60, 85 e 120 massas solares. Estes perfis foram calculados com o auxílio de um código numérico adequado para descrever os ventos de objetos massivos, supondo simetria esférica, estacionaridade e homogeneidade. No presente trabalho, apresentamos a complementação da grade com os perfis teóricos relativos às trajetórias de Z = 0.02 com taxa de perda de massa dobrada em relação a padrão (2´), e de metalicidade Z = 0.008. Para cada ponto das três trajetórias obtemos os perfis teóricos de Ha, Hb, Hg e Hd, e como esperado eles se apresentam em pura emissão, pura absorção ou em P-Cygni. Para valores de taxa de perda de massa muito baixos (~10-7) não há formação de linhas, o que é visto nos primeiros pontos em todas as trajetórias. Em geral, para um mesmo ponto a componente de emissão diminui e a absorção aumenta de Ha para Hd. É verificado que as trajetórias com Z = 0.02 e padrão possuem menos circuitos (loops) do que as com metalicidade Z = 0.02 e 2´ padrão, e seus perfis são, em geral, menos intensos. Em relação a trajetória de Z = 0.008, verifica-se menos circuitos e maior variação em luminosidade, e seus perfis mostram-se em, algumas trajetórias, mais intensos. Verificamos também que, pontos distintos em uma mesma trajetória, apresentam perfis diferentes para valores similares de luminosidade e temperatura efetiva. Sendo assim, uma grade de perfis teóricos parece ser útil para fornecer uma informação preliminar sobre o estágio evolutivo de uma estrela massiva.

  9. Pecos National Monument, New Mexico: Its Geologic Setting

    USGS Publications Warehouse

    Johnson, Ross Byron

    1969-01-01

    The ruins of the pueblos and missions of Pecos lie on the east bank of Glorieta Creek near its junction with the Pecos River at the south end of the Sangre de Cristo Mountains in north-central New Mexico. Here the Pecos River and Glorieta Creek have formed a broad rolling valley in which the red adobe walls of the mission church stand as a striking monument to a historic past. This is beautiful country; the bright hues of red rocks are complemented by the varied greens of the junipers, pi?ons, and ponderosa pines. Northward the Sangre de Cristo Mountains stretch for miles in a blue mist toward the Truchas Peaks and forests of the Pecos Wilderness. A few miles south of the ruins the steep high escarpment of Glorieta Mesa marks, in a general way, the southern termination of the Rocky Mountain System, which here is represented by the Sangre de Cristos. The escarpment of Glorieta Mesa has been formed largely by the Pecos River and its tributaries eroding the soft sedimentary layers. The Pecos flows southward from the high mountains in the north, parallels the mesa escarpment for 15 miles, and breaches the mesa near San Jose. About 1-1/2 miles southwest of the Pecos ruins at Cerro de Escobas is the highest point on Glorieta Mesa. It is the most conspicuous feature of the local landscape and rises to an elevation of 8,212 feet - 1,270 feet above the ruins. The slope of the escarpment here is very steep, rising 6 feet in every 10 horizontal feet. Along the north side of the Glorieta Mesa escarpment is a 30-mile-long natural pass around the south end of the Sangre de Cristos that extends from Canoncito on the west to Starvation Peak on the east (fig. 1). The elevation of the pass is greater than 6,000 feet at all places, and it reaches its summit of 7,432 feet near the village of Glorieta near the west end of the pass. This pass has been used as a major travel route for more than 800 years by the Indians, Spanish, and Americans. The famous Santa Fe Trail passed through

  10. Ground water recharge to the aquifers of northern San Luis Valley, Colorado: A remote sensing investigation

    NASA Technical Reports Server (NTRS)

    Lee, K. (Principal Investigator); Huntley, D.

    1976-01-01

    The author has identified the following significant results. Ground water recharge to the aquifers of San Luis Valley west of San Luis Creek was primarily from ground water flow in the volcanic aquifers of the San Juan Mountains. The high permeability and anisotropic nature of the volcanic rocks resulted in very little contrast in flow conditions between the San Juan Mountains and San Luis Valley. Ground water recharge to aquifers of eastern San Luis Valley was primarily from stream seepage into the upper reaches of the alluvial fans at the base of the Sangre de Cristo Mountains. The use of photography and thermal infrared imagery resulted in a savings of time and increase in accuracy in regional hydrogeologic studies. Volcanic rocks exhibited the same spectral reflectance curve as sedimentary rocks, with only the absolute magnitude of reflectance varying. Both saline soils and vegetation were used to estimate general ground water depths.

  11. Evaluation of the mutagenic, antimutagenic and antiproliferative potential of Croton lechleri (Muell. Arg.) latex.

    PubMed

    Rossi, D; Bruni, R; Bianchi, N; Chiarabelli, C; Gambari, R; Medici, A; Lista, A; Paganetto, G

    2003-03-01

    Sangre de Drago is a red viscous latex extracted from Croton lechleri (Euphorbiaceae) cortex, renowned in South American popular medicine for its wound-healing properties. The in vitro antiproliferative effects were determined on the human myelogenous leukemia K562 cells line (IC50 = 2.5 +/- 0.3 microg ml(-1)). The mutagenic and antimutagenic activity of C. lechleri sap was examined by means of the Ames/Salmonella test. No mutagenic activity was found on the Salmonella typhimurium strains T98 and T100, either with or without S9 activation. On the other hand, the sap showed an inhibitory effect against the mutagenic activity of the indirectly acting mutagen 2-Aminoanthracene in presence of S9 and a moderate protective activity against directly acting mutagens Sodium Azide and 2-Nitrofluorene. Therefore we suggest that C. lechleri sap interacts with the enzymes of the S9 mix, thereby inhibiting the transformation of 2-Aminoantracene into its active forms.

  12. 2005 annual progress report: Elk and bison grazing ecology in the Great Sand Dunes complex of lands

    USGS Publications Warehouse

    Schoenecker, Kate A.; Lubow, Bruce C.; Zeigenfuss, Linda C.; Mao, Julie

    2006-01-01

    To address the questions and needs of local resource managers, a multi-agency research project was initiated in 2005 to study the ecology, forage relations, and habitat relations of elk and bison in the Great Sand Dunes–Sangre de Cristo–Baca complex of lands. Meetings and discussions of what this research should include were started in 2001 with representatives from NPS, USFWS, TNC, the Colorado Division of Wildlife (CDOW), and USDA-FS/BLM. The final study plan was successfully funded in 2004 with research scheduled to start in 2005. The research was designed to encompass three major study elements: (1) animal movements and population dynamics, (2) vegetation and nutrient effects from ungulate herbivory, and (3) development of ecological models, using empirical data collected from the first two components, that will include estimates of elk carrying capacity and management scenarios for resource managers.

  13. [Blood and urine lead levels in children with attention deficit hyperactivity disorder].

    PubMed

    Sánchez-Villegas, M del Carmen S; Cortés-Vargas, Astrid; Hidalgo-Luna, Ricardo Gerardo; Alam-Escamilla, David Abraham; Vargas-García, Víctor Manuel; Loría-Castellanos, Jorge

    2014-01-01

    INTRODUCCIÓN: los síntomas del trastorno por déficit de atención e hiperactividad pueden persistir hasta la vida adulta en 60 % de quienes la padecieron en la niñez. Nuestro objetivo fue cuantificar los niveles de plomo en la sangre y la orina en niños con diagnóstico de trastorno por déficit de atención e hiperactividad para identificar si existe alguna relación. MÉTODOS: estudio observacional que incluyó a una muestra cautiva del Servicio de Higiene Mental del Hospital General del Centro Médico Nacional La Raza, con diagnóstico de trastorno por déficit de atención e hiperactividad. Se cuantificaron los niveles séricos y urinarios del plomo mediante la técnica de absorción atómica.

  14. Bioactive Compounds from Plants Used in Peruvian Traditional Medicine.

    PubMed

    Lock, Olga; Perez, Eleucy; Villar, Martha; Flores, Diana; Rojas, Rosario

    2016-03-01

    It is estimated that there are as many as 1400 plant species currently used in traditional Peruvian medicine; however, only a few have undergone scientific investigation. In this paper, we make a review of the botanical, chemical, pharmacological and clinical propierties of the most investigated Peruvian medicinal plants. The plant species selected for this review are: Smallanthus sonchifolius (yacon), Croton lechleri (sangre de grado), Uncaria tomentosa/U. guianensis (uña de gato), Lepidium meyenii (maca), Physalis peruviana (aguaymanto), Minthostachys mollis (muña), Notholaena nivea (cuti-cuti), Maytenus macrocarpa (chuchuhuasi), Dracontium loretense (jergon sacha), Gentianella nitida (hercampuri), Plukenetia volubilis (sacha inchi) and Zea mays (maiz morado). For each of these plants, information about their traditional uses and current commercialization is also included. PMID:27169179

  15. Bioactive Compounds from Plants Used in Peruvian Traditional Medicine.

    PubMed

    Lock, Olga; Perez, Eleucy; Villar, Martha; Flores, Diana; Rojas, Rosario

    2016-03-01

    It is estimated that there are as many as 1400 plant species currently used in traditional Peruvian medicine; however, only a few have undergone scientific investigation. In this paper, we make a review of the botanical, chemical, pharmacological and clinical propierties of the most investigated Peruvian medicinal plants. The plant species selected for this review are: Smallanthus sonchifolius (yacon), Croton lechleri (sangre de grado), Uncaria tomentosa/U. guianensis (uña de gato), Lepidium meyenii (maca), Physalis peruviana (aguaymanto), Minthostachys mollis (muña), Notholaena nivea (cuti-cuti), Maytenus macrocarpa (chuchuhuasi), Dracontium loretense (jergon sacha), Gentianella nitida (hercampuri), Plukenetia volubilis (sacha inchi) and Zea mays (maiz morado). For each of these plants, information about their traditional uses and current commercialization is also included.

  16. Evaluation of the mutagenic, antimutagenic and antiproliferative potential of Croton lechleri (Muell. Arg.) latex.

    PubMed

    Rossi, D; Bruni, R; Bianchi, N; Chiarabelli, C; Gambari, R; Medici, A; Lista, A; Paganetto, G

    2003-03-01

    Sangre de Drago is a red viscous latex extracted from Croton lechleri (Euphorbiaceae) cortex, renowned in South American popular medicine for its wound-healing properties. The in vitro antiproliferative effects were determined on the human myelogenous leukemia K562 cells line (IC50 = 2.5 +/- 0.3 microg ml(-1)). The mutagenic and antimutagenic activity of C. lechleri sap was examined by means of the Ames/Salmonella test. No mutagenic activity was found on the Salmonella typhimurium strains T98 and T100, either with or without S9 activation. On the other hand, the sap showed an inhibitory effect against the mutagenic activity of the indirectly acting mutagen 2-Aminoanthracene in presence of S9 and a moderate protective activity against directly acting mutagens Sodium Azide and 2-Nitrofluorene. Therefore we suggest that C. lechleri sap interacts with the enzymes of the S9 mix, thereby inhibiting the transformation of 2-Aminoantracene into its active forms. PMID:12725567

  17. HBV and HAV infection in chronic hepatitis in Argentina.

    PubMed

    Tanno, H; Fay, O H; Roncoroni, M; Palazzi, J

    1981-01-01

    Sera of 155 chronic hepatitis (CH) patients in Argentina were tested for the presence of HBsAg, anti-HBs, anti-HBc, and anti-HAV. Our purpose was to define the role that both virus A and B might play in the etiology and pathogenesis of this condition. The patients were divided into two groups: group I (57) HBsAg-negative; group II (98) HBsAg-positive. The control group consisted of 1,209 healthy blood donors from Banco Central de Sangre de Rosario; 286/1,209 (24%) had viral markers for HBV. In group I, 38/57 (67%) had anti-HBs and/or anti-HBc, but none had anti-HBs alone. Group II showed a higher percentage of males (P less than 0.05). We found similar incidence of anti-HAV among group I, group II, and the control group.

  18. [Aicardi-Goutieres syndrome due to mutation of the IFIH1 gene with pontine involvement. A case report].

    PubMed

    Florido-Rodriguez, A; Eiris-Punal, J; Barros-Angueira, F; Toledo-Bravo de Laguna, L; Santana-Artiles, A; Sebastian-Garcia, I; Santana-Rodriguez, A; Cabrera-Lopez, J C

    2016-10-01

    Introduccion. El sindrome de Aicardi-Goutieres es una rara encefalopatia subaguda progresiva de inicio precoz –generalmente en el primer año de vida– caracterizada por retraso psicomotor, microcefalia, alteraciones en la sustancia blanca cerebral, calcificaciones intracraneales, pleocitosis y niveles elevados de interferon alfa en el liquido cefalorraquideo. Asocia un incremento en la expresion de los genes estimulados por interferon en la sangre periferica, hecho conocido como interferon signature. Los niveles de genes estimulados por interferon se han postulado como un buen biomarcador, pues se mantienen elevados en la sangre periferica en el tiempo y son mas sensibles, en comparacion con las determinaciones de interferon alfa y neopterinas en el liquido cefalorraquideo, las cuales descienden a partir del año de vida. Hasta la fecha se han descrito mutaciones en siete genes que sobreestimulan la via del interferon alfa, y el ultimo en descubrirse ha sido el IFIH1 (interferon induced with helicase C domain 1), con un patron de herencia autosomico dominante. Caso clinico. Se presenta el primer caso descrito en la bibliografia hispana debido a mutacion de novo en el gen IFIH1. Se expone el cuadro clinico, los estudios realizados y la revision de los aspectos clinicos, neurorradiologicos y geneticos. Conclusiones. La herencia de las mutaciones descritas para el sindrome de Aicardi-Goutieres era clasicamente autosomica recesiva, pero estos hallazgos muestran que mutaciones autosomicas dominantes en el gen IFIH1 pueden causar la enfermedad. Como hallazgo de neuroimagen no descrito previamente, presenta una lesion de encefalomalacia quistica en la protuberancia.

  19. [Accidental finding of a cri du chat syndrome in an adult patient by means of array-CGH].

    PubMed

    Ferreirós-Martínez, Raquel; López-Manzanares, Lydia; Alonso-Cerezo, Concepción

    2014-07-16

    Introduccion. El sindrome cri du chat (SCDC) tiene su origen en una delecion parcial o total del brazo corto del cromosoma 5, y es uno de los sindromes de delecion cromosomica mas frecuentes en humanos. La mayoria de los pacientes se diagnostica entre el primer mes y el primer año de vida, si bien aqui se describe el hallazgo de un SCDC en una mujer con sospecha de ataxia espinocerebelar y antecedentes familiares de trastorno bipolar y ataxia, con especial atencion a las caracteristicas clinicas y las tecnicas diagnosticas que permitieron su identificacion. Caso clinico. Mujer de 46 años que presentaba una inteligencia limite, intervenida a los 43 años de faquectomia bilateral. El inicio de la sintomatologia fue durante la infancia, e incluia hipoacusia, ataxia, disartria, disfagia, depresion, deterioro cognitivo y trastorno bipolar. La exploracion fisica revelo microcefalia, micrognatia, pies equinos y ataxia. Se realizo cariotipo y array-CGH en sangre periferica. La paciente presentaba una traslocacion que involucraba los cromosomas 5 y 15, y una inversion del cromosoma 9: 45,XX,inv9(p11q13);t(5,15)(p15.33;q11.2). El array-CGH mostro una delecion de 2,91 Mb en 5p15.33, formula genomica arr 5p15.33 (151537-3057771)x1, que involucraba 20 genes, incluyendo el gen TERT. Conclusiones. La delecion de multiples genes confirmo el diagnostico de SCDC y es la responsable del fenotipo de la paciente. Se pone de manifiesto la importancia de utilizar tecnicas adecuadas de diagnostico (array-CGH, cariotipo en sangre periferica) y la correcta eleccion de estas.

  20. Variability of formulas to assess insulin sensitivity and their association with the Matsuda index.

    PubMed

    Henríquez, Sandra; Jara, Natalia; Bunout, Daniel; Hirsch, Sandra; de la Maza, María Pía; Leiva, Laura; Barrera, Gladys

    2013-01-01

    Objetivo: Evaluar la variabilidad individual de los índices HOMA y QUICKI para resistencia a insulina, utilizando tres muestras de sangre en ayunas obtenidas en un período de 30 minutos. Material y métodos: Se utilizaron datos provenientes de 80 participantes de 41.5 ± 15 años de edad (26 mujeres) a quienes se les efectuó una prueba de tolerancia a glucosa oral para calcular el índice de Matsuda. A cada participante se le tomaron tres muestras de sangre en ayunas en un período de 30 minutos y cuatro muestras a los 30, 60, 90 y 120 minutos después de una carga oral de 75 g de glucosa. En cada muestra se midieron los niveles de insulina y glucosa. Los índices HOMA y QUICKI se calcularon utilizando las nueve combinaciones posibles con las tres muestras obtenidas en ayunas. El índice de Matsuda se calculó utilizando todas las muestras. Resultados: Las medianas de los índices HOMA-IR, HOMA-?, QUICKI y Matsuda fueron 1,9, 117,9, 0,35 and 3,71 unidades arbitrarias, respectivamente. Los coeficientes de variación individual del HOMA-IR, HOMA-??y QUICKI fueron 11,8 (7,8-18,9), 15 (10,2-22,9) and 1,8 (8,8-21,9) %, respectivamente. Comparados con el índice de Matsuda, los valores de R2 para el HOMA-IR, HOMA-??y QUICKI fueron 0,46, 0,2 y 0,71, respectivamente. Conclusiones: De los índices que utilizan muestras en ayunas para determinar resistencia a insulina, el QUICKI es el que tiene el menor coeficiente de variación y la mejor correlación con el índice de Matsuda.

  1. Geologic Map of the San Luis Quadrangle, Costilla County, Colorado

    USGS Publications Warehouse

    Machette, Michael N.; Thompson, Ren A.; Drenth, Benjamin J.

    2008-01-01

    The map area includes San Luis and the primarily rural surrounding area. San Luis, the county seat of Costilla County, is the oldest surviving settlement in Colorado (1851). West of the town are San Pedro and San Luis mesas (basalt-covered tablelands), which are horsts with the San Luis fault zone to the east and the southern Sangre de Cristo fault zone to the west. The map also includes the Sanchez graben (part of the larger Culebra graben), a deep structural basin that lies between the San Luis fault zone (on the west) and the central Sangre de Cristo fault zone (on the east). The oldest rocks exposed in the map area are the Pliocene to upper Oligocene basin-fill sediments of the Santa Fe Group, and Pliocene Servilleta Basalt, a regional series of 3.7?4.8 Ma old flood basalts. Landslide deposits and colluvium that rest on sediments of the Santa Fe Group cover the steep margins of the mesas. Rare exposures of the sediment are comprised of siltstones, sandstones, and minor fluvial conglomerates. Most of the low ground surrounding the mesas and in the graben is covered by surficial deposits of Quaternary age. The alluvial deposits are subdivided into three Pleistocene-age units and three Holocene-age units. The oldest Pleistocene gravel (unit Qao) forms extensive coalesced alluvial fan and piedmont surfaces, the largest of which is known as the Costilla Plain. This surface extends west from San Pedro Mesa to the Rio Grande. The primary geologic hazards in the map area are from earthquakes, landslides, and localized flooding. There are three major fault zones in the area (as discussed above), and they all show evidence for late Pleistocene to possible Holocene movement. The landslides may have seismogenic origins; that is, they may be stimulated by strong ground shaking during large earthquakes. Machette and Thompson based this geologic map entirely on new mapping, whereas Drenth supplied geophysical data and interpretations.

  2. [The cord blood bank at the Instituto Mexicano del Seguro Social].

    PubMed

    Peñaflor-Juárez, Karina; Guillén-Chan, Sonia Marilyn; Romero-Juárez, Yanín; Luna-Bautista, Fernando; Franco-Gutiérrez, Elizabeth; Arellano-Ocampo, Jesús Salvador; Ibáñez-Sánchez, Rocío; de Lourdes Domínguez-Contreras, María; Guerra-Márquez, Angel

    2015-01-01

    Introducción: las células troncales hematopoyéticas se han empleado por más de 50 años en el tratamiento de diversas enfermedades. La sangre de cordón umbilical es una fuente viable de células troncales hematopoyéticas con fines de trasplante. El objetivo es informar la aportación clínica del banco de células de cordón umbilical (BCCU) en el tratamiento de diversas enfermedades.Métodos: desde 2005 a la fecha se analizó el número de unidades de sangre de cordón umbilical (SCU) y su empleo para el trasplante en diversas enfermedades. Se seleccionaron donadoras embarazadas voluntarias en trabajo de parto de quienes se recolectó SCU, la cual fue sometida a su procesamiento, criopreservación y validación, así como a estudios de compatibilidad previo a su uso para trasplante.Resultados: se evaluaron 10 099 candidatas a donación, de quienes se recolectaron 2481 unidades de SCU, de estas se procesaron y criopreservaron 893 unidades para trasplante. En 65 % de los casos hubo histocompatibilidad entre las células de cordón y el receptor. Se trasplantaron 87 pacientes (67 % neoplasias hematológicas), que recibieron 140 unidades SCU en 102 trasplantes.Conclusiones: nuestro Banco de CCU ha logrado desarrollar una línea celular (troncales hematopoyéticas) con estándares de calidad internacionales, y ha beneficiado a pacientes con necesidad de un trasplante, en especial los padecimientos oncohematológicos.

  3. [Autoreactive TCD8+ lymphocytes in patients with chronic myeloid leukemia in association with HLA and adenovirus infection].

    PubMed

    Rivera, Sergio E; Echeverría, Miriam; Salcedo, Pedro; Márquez, Georgina; Carrillo, Zuhey; Parra, Yennis; Cipriani, Ana María; Núñez, José R; Álvarez de Mon, Melchor; Farruco, Atilio

    2016-01-01

    Antecedentes: algunos adenovirus se han señalado como activadores clonales en leucemias. El alelo HLA-DRB1* 14 subtipos DRB1*14:21, 14:22, 14:45, 14:26, 14:33, 14:51, 14:35 se asociaron con leucemia mieloide crónica (LMC) en pacientes venezolanos. Objetivo: evaluar el mimetismo molecular entre el adenovirus y la estructura del antígeno HLA-DRB1*14 que exhiben el mismo cambio en la posición de aminoácido del epítopo DR53. Material y método: estudio experimental realizado en el IHO Banco de Sangre del Estado Zulia, Venezuela en muestras de sangre periférica de pacientes con LLA, LMC y controles sanos. Se realizaron cultivo mixto de linfocitos, serología, proliferación linfocitaria y citofluorometría. Resultados: los linfocitos DRB1*14 del paciente reaccionaron en 48 horas versus los linfocitos DRB1*14 estimuladores, que exhibieron aumento de los linfocitos T CD8+. Los pacientes con LMC tuvieron un perfil serológico diferente contra el adenovirus. Sólo pacientes con LMC reaccionaron frente al péptido secuencia LLERRRA con incremento de las células TCD8+. Conclusión: se estableció que la relación leucemia mieloide crónica, HLA-DRB1*14, células TCD8+ de memoria autorreactivas y TCD8+ en respuesta específica frente al adenovirus podría estar en el origen de la leucemia mieloide crónica de pacientes venezolanos.

  4. Dickeyafangzhongdai sp. nov., a plant-pathogenic bacterium isolated from pear trees (Pyrus pyrifolia).

    PubMed

    Tian, Yanli; Zhao, Yuqiang; Yuan, Xiaoli; Yi, Jianping; Fan, Jiaqin; Xu, Zhigang; Hu, Baishi; De Boer, Solke H; Li, Xiang

    2016-09-01

    Gram-stain-negative, pectinolytic bacteria were repeatedly isolated from pear trees displaying symptoms of bleeding canker in China. Three strains, JS5T, LN1 and QZH3, had identical 16S rRNA gene sequences that shared 99 % similarity to the type strain of Dickeya dadantii. Phylogenetic analysis of strains JS5T, LN1 and QZH3 with isolates representing all species of the genus Dickeya and related Pectobacterium species supported their affiliation to Dickeya. Multi-locus sequence typing employing concatenated sequences encoding recA, fusA, gapA, purA, rplB, dnaX and the intergenic spacer illustrated a phylogeny which placed strains JS5T, LN1 and QZH3 as a distinct clade, separate from all other species of the genus Dickeya. Average nucleotide identity values obtained in comparison with all species of the genus Dickeya supported the distinctiveness of strain JS5T within the genus Dickeya. Additionally, all three strains were phenotypically distinguished from other species of the genus Dickeya by failing to hydrolyse casein, and by producing acids from (-)-d-arabinose, (+)melibiose, (+)raffinose, mannitol and myo-inositol, but not from 5-keto-d-gluconate or β-gentiobiose. The name Dickeya fangzhongdai sp. nov. is proposed to accommodate these strains; the type strain is JS5T (=CGMCC 1.15464T=DSM 101947T). PMID:27045848

  5. Oil Bypass Filter Technology Evaluation, Fourth Quarterly Report, July--September 2003

    SciTech Connect

    James E. Francfort; Larry Zirker

    2003-11-01

    This fourth Oil Bypass Filter Technology Evaluation report details the ongoing fleet evaluation of an oil bypass filter technology by the Idaho National Engineering and Environmental Laboratory (INEEL) for the U.S. Department of Energy’s FreedomCAR & Vehicle Technologies Program. Eight four-cycle diesel-engine buses used to transport INEEL employees on various routes have been equipped with oil bypass filter systems from the puraDYN Corporation. The bypass filters are reported to have engine oil filtering capability of <1 micron and a built-in additive package to facilitate extended oil-drain intervals. To date, the eight buses have accumulated 259,398 test miles. This represents an avoidance of 21 oil changes, which equates to 740 quarts (185 gallons) of oil not used or disposed of. To validate the extended oil-drain intervals, an oil-analysis regime evaluates the fitness of the oil for continued service by monitoring the presence of necessary additives, undesirable contaminants, and engine-wear metals. For bus 73450, higher values of iron have been reported, but the wear rate ratio (parts per million of iron per thousand miles driven) has remained consistent. In anticipation of also evaluating oil bypass systems on six Chevrolet Tahoe sport utility vehicles, the oil is being sampled on each of the Tahoes to develop a characterization history or baseline for each engine.

  6. Molecular characterization of virulence genes of Streptococcus equi subsp. equi and Streptococcus equi subsp. zooepidemicus in equines

    PubMed Central

    Javed, R.; Taku, A. K.; Gangil, Rakhi; Sharma, R. K.

    2016-01-01

    Aim: The aim was to determine the occurrence of streptococci in equines in Jammu (R. S. Pura, Katra), characterization of Streptococci equi subsp. equi and Streptococcus equi subsp. zooepidemicus with respect to their virulence traits and to determine antibiotic sensitivity pattern of virulent Streptococcus isolates. Materials and Methods: A total of 96 samples were collected from both clinically affected animals (exhibiting signs of respiratory tract disease) and apparently healthy animals and were sent to laboratory. The organisms were isolated on Columbia nalidixic acid agar containing 5% sheep blood as well as on sheep blood agar and confirmed by cultural characteristics and biochemical tests. Molecular detection of Streptococcus was done directly from cultures using sodA and seM gene-based polymerase chain reaction (PCR). Antibiogram was performed against five antibiotics such as amoxicillin, penicillin G, streptomycin, rifampicin, and methicillin. Results: During this study, a total 40 streptococcal isolates were obtained out of which 2 isolates were of S. equi subsp. equi, 12 isolates were from S. equi subsp. zooepidemicus. In the PCR-based detection, we revealed amplicons of 235 bp and 679 bp for confirmation of sodA and seM gene, respectively. In antibiogram, two isolates of S. equi subsp. equi were found resistant to penicillin G, and all other isolates were found sensitive to amoxicillin and streptomycin. Conclusion: The majority of streptococcal infections was due to S. equi subsp. Zooepidemicus, and thus was recognized as a potential pathogen of diseases of equines besides S. equi subsp. equi.

  7. Silvopastoralism and autochthonous equine livestock: analysis of the infection by endoparasites.

    PubMed

    Francisco, I; Arias, M; Cortiñas, F J; Francisco, R; Mochales, E; Sánchez, J A; Uriarte, J; Suárez, J L; Morrondo, P; Sánchez-Andrade, R; Díez-Baños, P; Paz-Silva, A

    2009-10-14

    Two groups of autochthonous Pura Raza Galega (PRG) horses, one comprising 483 animals under a silvopasturing regime, and the other comprising 72 PRG horses managed in farms, were used to analyse the effect of silvopasture on infection by endoparasites. Results were considered according to the age and the sex of the horses. Faecal samples were individually collected from each animal and analysed by the coprological flotation, sedimentation and migration techniques. Coprocultures were also done to identify the main strongylid genera affecting the horses. Eggs from the gastrointestinal nematoda Parascaris equorum, strongyles and Oxyuris equi were the only endoparasites observed in the faeces of the horses. Larvae of Trichonema and Cyalocephalus spp. (small strongyles) and Strongylus and Triodontophorus (large strongyles) were identified in the coprocultures. The silvopasturing horses had the highest prevalence of the helminth parasites. The percentage of horses passing ascarid eggs was significantly higher in pasturing horses younger than 3 years. The prevalence of strongyles was statistically greater in the oldest grazing equines. Mares reached the highest prevalence of helminth egg output. Our results showed that native horses kept under silvopasture had the highest prevalence of the ascarids, strongyles and oxyurids, possibly due to their exposure to contaminated grazing areas, lack of appropriate feeding and control of their health status. We conclude that silvopasture increases the presence of infection by gastrointestinal nematoda in wild horses, especially by strongyles. Suitable measures to control parasitic diseases affecting horses in silvopasture should be considered in those systems. PMID:19632049

  8. Wave propagation in magnetic fluids

    NASA Astrophysics Data System (ADS)

    Cissoko, Mahdy

    1987-08-01

    This paper deals within the relativistic framework with the wave propagation in magnetizable fluids, assumed to be perfect, magnetically soft, isotropic, and inhomogeneous with an arbitrary isotropic law χ=χ(T,r,||b||2) (χ,T,r,||b|| being the magnetic susceptibility, the proper temperature, the proper material density, and the strength of the magnetic field, respectively). The characteristic manifolds of the flow are determined in a very elegant and rigorous manner which avoids the extensive algebraic manipulations one usually encounters in the classical methods of characteristics. It is shown that in a magnetic medium there exists a hyperbolic region of nonsteady flows of magnetizable fluids. This implies the existence of magnetosonic waves of the same kind as in nonmagnetic fluids (χ or μ=const), that is, as in ordinary magnetohydrodynamics. However, in magnetic fluids there is the possibility of the development of instabilities similar to that which arise in nonmagnetic fluids with transverse and longitudinal pressure [M. Cissoko, Ann. Mat. Pura Appl. 111, 331 (1976)].

  9. U.S. Department of Energy FreedomCAR & Vehicle Technologies Program Oil Bypass Filter Technology Evaluation - Sixth Quarterly Report, January - March 2004

    SciTech Connect

    U.S. Department of Energy; Larry Zirker

    2004-06-01

    This Oil Bypass Filter Technology Evaluation quarterly report (January-March 2004) details the ongoing fleet evaluation of an oil bypass filter technology by the Idaho National Engineering and Environmental Laboratory (INEEL) for the U.S. Department of Energy's FreedomCAR & Vehicle Technologies Program. Eight four-cycle diesel-engine buses used to transport INEEL employees on various routes have been equipped with oil bypass filter systems from the puraDYN Corporation. The bypass filters are reported to have engine oil filtering capability of <1 micron and a built-in additive package to facilitate extended oil-drain intervals. This quarter, the heavy-duty buses traveled 88,747 miles, and as of the end of March 2004, the eight buses have accumulated 412,838 total test miles without requiring an oil change. This represents an avoidance of 34 oil changes, which equates to 1,199 quarts (300 gallons) of new oil not consumed and, furthermore, 1,199 quarts of waste oil not generated.

  10. Development of A Three-Dimensional Tissue Construct from Dental Human Ectomesenchymal Stem Cells: In Vitro and In Vivo Study

    PubMed Central

    Guzmán-Uribe, Daniela; Estrada, Keila Neri Alvarado; Guillén, Amaury de Jesús Pozos; Pérez, Silvia Martín; Ibáñez, Raúl Rosales

    2012-01-01

    Application of regenerative medicine technology provides treatment for patients with several clinical problems, like loss of tissue and its function. The investigation of biological tooth replacement, dental tissue engineering and cell culture, scaffolds and growth factors are considered essential. Currently, studies reported on the making of threedimensional tissue constructs focused on the use of animal cells in the early stages of embryogenesis applied to young biomodels. The purpose of this study was the development and characterization of a three-dimensional tissue construct from human dental cells. The construct was detached, cultured and characterized in mesenchymal and epithelial cells of a human tooth germ of a 12 year old patient. The cells were characterized by specific membrane markers (STRO1, CD44), making a biocomplex using Pura Matrix as a scaffold, and it was incubated for four days and transplanted into 30 adult immunosuppressed male Wistar rats. They were evaluated at 6 days, 10 days and 2 months, obtaining histological sections stained with hematoxylin and eosin. Cell cultures were positive for specific membrane markers, showing evident deviations in morphology under phase contrast microscope. Differentiation and organization were noted at 10 days, while the constructs at 2 months showed a clear difference in morphology, organization and cell type. It was possible to obtain a three-dimensional tissue construct from human dental ectomesenchymal cells achieving a degree of tissue organization that corresponds to the presence of cellular stratification and extracellular matrix. PMID:23308086

  11. [Neuroethics (I): moral pathways in normal brain].

    PubMed

    Álvaro-González, Luis C

    2014-03-01

    Introduccion. La moralidad es el conjunto de normas y valores que guian la conducta. Se mantienen en muy diferentes culturas. Permiten alcanzar logros sociales que solo se entienden bajo el desarrollo moral, con un sentido de justicia que penetra toda accion humana. Las funciones morales, fruto del desarrollo evolutivo, asientan en circuitos neuronales propios. Objetivo. Describir su aparicion, puesta en marcha y mecanismos operativos en el cerebro normal. Desarrollo. Las respuestas morales, en lo esencial homogeneas, estan muy vinculadas al desarrollo emocional, tanto basico e individual (miedo o ira) como social (compasion o justicia). Aparecen a partir de los binomios emocionales placer/dolor y recompensa/castigo, que conducen al binomio moral basico bueno/malo. En su puesta en marcha intervienen la corteza prefrontal (ventromedial y dorsolateral), la corteza cingular anterior y el sulco temporal superior, que serian evaluativos y elaborativos, utilitaristas; tambien la insula, la amigdala y el hipotalamo, ejecutivos de las respuestas morales mas emocionales puras y rapidas. Asimismo, es importante el sistema de neuronas espejo (frontoparietal), que permite el aprendizaje motor y las conductas empaticas, con las que se vincula con la teoria de la mente. Conclusiones. El desarrollo del sentido moral y sus respuestas nos han permitido alcanzar una complejidad y convivencia social que redundan en beneficio de la especie e individuos. El conocimiento del funcionamiento moral esta influyendo tambien en territorios diversos de la neurocultura.

  12. Development of a three-dimensional tissue construct from dental human ectomesenchymal stem cells: in vitro and in vivo study.

    PubMed

    Guzmán-Uribe, Daniela; Estrada, Keila Neri Alvarado; Guillén, Amaury de Jesús Pozos; Pérez, Silvia Martín; Ibáñez, Raúl Rosales

    2012-01-01

    Application of regenerative medicine technology provides treatment for patients with several clinical problems, like loss of tissue and its function. The investigation of biological tooth replacement, dental tissue engineering and cell culture, scaffolds and growth factors are considered essential. Currently, studies reported on the making of threedimensional tissue constructs focused on the use of animal cells in the early stages of embryogenesis applied to young biomodels. The purpose of this study was the development and characterization of a three-dimensional tissue construct from human dental cells. The construct was detached, cultured and characterized in mesenchymal and epithelial cells of a human tooth germ of a 12 year old patient. The cells were characterized by specific membrane markers (STRO1, CD44), making a biocomplex using Pura Matrix as a scaffold, and it was incubated for four days and transplanted into 30 adult immunosuppressed male Wistar rats. They were evaluated at 6 days, 10 days and 2 months, obtaining histological sections stained with hematoxylin and eosin. Cell cultures were positive for specific membrane markers, showing evident deviations in morphology under phase contrast microscope. Differentiation and organization were noted at 10 days, while the constructs at 2 months showed a clear difference in morphology, organization and cell type. It was possible to obtain a three-dimensional tissue construct from human dental ectomesenchymal cells achieving a degree of tissue organization that corresponds to the presence of cellular stratification and extracellular matrix. PMID:23308086

  13. Sex reversal syndrome in the horse: four new cases of feminization in individuals carrying a 64,XY SRY negative chromosomal complement.

    PubMed

    Anaya, Gabriel; Moreno-Millán, Miguel; Bugno-Poniewierska, Monika; Pawlina, Klaudia; Membrillo, Alberto; Molina, Antonio; Demyda-Peyrás, Sebastián

    2014-12-10

    Horses are characterized as having a greater rate of chromosomal abnormalities than other species, which are mainly related to the sex chromosome pair and produce a series of different anomalies known as disorders in sexual development (DSD). In the present study, three Pura Raza Española (PRE) and one Menorquín (MEN) horses were studied and an incompatibility in their genetic and phenotypic sex were detected. Animals were karyotyped by conventional and molecular cytogenetic analyses and characterized using genomic techniques. Although all individuals, were totally unrelated, these animals had the same abnormality (64,XY SRY negative DSD) despite having an anatomically normal external mare phenotype. Therefore, this syndrome could remain undiagnosed in a large percentage of cases because the physiological and morphological symptoms are rare. In the present study, a slight gonadal dysgenesis was observed only in older individuals. Interestingly this chromosomal abnormality has been previously reported less than twenty times, and never in the PRE or MEN horses. With the present research, it is demonstrated that the use of genetic and cytogenetic diagnostic tools in veterinary practice could be an important complementary test to determine the origin of unexplained reproductive failures among horses.

  14. Ability of the fungus Duddingtonia flagrans to adapt to the cyathostomin egg-output by spreading chlamydospores.

    PubMed

    Paz-Silva, A; Francisco, I; Valero-Coss, R O; Cortiñas, F J; Sánchez, J A; Francisco, R; Arias, M; Suárez, J L; López-Arellano, M E; Sánchez-Andrade, R; de Gives, P Mendoza

    2011-06-30

    The analysis of the capability of the nematode trapping-fungus Duddingtonia flagrans to adapt to the cyathostomin egg-output in horses was evaluated. Fecal samples from 196 pasturing autochthonous Pura Raza Galega horses were collected from the rectum and then divided according to the egg-output into three groups: ≤ 300, 310-800 and >800 eggs per gram feces. Four doses of chlamydospores (0.1, 0.2, 0.4 and 0.8 × 10(6)/100g feces) were directly spread onto fecal pats on the ground, remaining one without treatment as control. Fecal pats confirmed the presence of gastrointestinal nematode larvae belonging to strongylid cyathostomins (Cyathostomum and Gyalocephalus spp). An overall 94% (95% CI 91, 97) percentage of reduction was obtained, and an increase in the activity of the trapping-fungi simultaneously to the rising in the number of cyathostomin eggs and larvae in the coprocultures was detected. A significantly highest reduction of the cyathostomin L3 in the coprocultures with more than 800 EPG was found, which indicates that Df trapping activity is larvae nematode density-dependant. The present research showed the high biological activity of D. flagrans against nematode larvae can adjust to the cyathostomin egg-output, and underlines its efficacy as a practical method for the control of these parasites in grazing horses.

  15. Dickeyafangzhongdai sp. nov., a plant-pathogenic bacterium isolated from pear trees (Pyrus pyrifolia).

    PubMed

    Tian, Yanli; Zhao, Yuqiang; Yuan, Xiaoli; Yi, Jianping; Fan, Jiaqin; Xu, Zhigang; Hu, Baishi; De Boer, Solke H; Li, Xiang

    2016-09-01

    Gram-stain-negative, pectinolytic bacteria were repeatedly isolated from pear trees displaying symptoms of bleeding canker in China. Three strains, JS5T, LN1 and QZH3, had identical 16S rRNA gene sequences that shared 99 % similarity to the type strain of Dickeya dadantii. Phylogenetic analysis of strains JS5T, LN1 and QZH3 with isolates representing all species of the genus Dickeya and related Pectobacterium species supported their affiliation to Dickeya. Multi-locus sequence typing employing concatenated sequences encoding recA, fusA, gapA, purA, rplB, dnaX and the intergenic spacer illustrated a phylogeny which placed strains JS5T, LN1 and QZH3 as a distinct clade, separate from all other species of the genus Dickeya. Average nucleotide identity values obtained in comparison with all species of the genus Dickeya supported the distinctiveness of strain JS5T within the genus Dickeya. Additionally, all three strains were phenotypically distinguished from other species of the genus Dickeya by failing to hydrolyse casein, and by producing acids from (-)-d-arabinose, (+)melibiose, (+)raffinose, mannitol and myo-inositol, but not from 5-keto-d-gluconate or β-gentiobiose. The name Dickeya fangzhongdai sp. nov. is proposed to accommodate these strains; the type strain is JS5T (=CGMCC 1.15464T=DSM 101947T).

  16. Epidemiology and neurological complications of infection by the Zika virus: a new emerging neurotropic virus.

    PubMed

    Carod-Artal, Francisco J

    2016-04-01

    Introduccion. El actual brote epidemico por virus Zika se inicio en 2015 y en la actualidad afecta a 31 paises y territorios en America. Se revisan los aspectos epidemiologicos y clinicos asociados con la infeccion por virus Zika. Desarrollo. Desde 2007, 55 paises de America, Asia, Africa y Oceania han detectado transmision local del virus. La actual epidemia ha afectado a casi 1,5 millones de personas en Brasil. El 80% de los casos son asintomaticos. La enfermedad por virus Zika cursa con fiebre, exantema maculopapular, artralgias y conjuntivitis no purulenta. Los sintomas suelen ser autolimitados y duran una semana. Se ha descrito un aumento de la incidencia de los casos de microcefalia, lesiones retinianas y sindrome de Guillain-Barre asociados con el virus Zika. El sindrome de Guillain-Barre asociado al Zika en la Polinesia es una variante axonal motora pura. El ARN del virus Zika se ha identificado en muestras de tejido cerebral, placenta y liquido amniotico de niños con microcefalia y en perdidas fetales de mujeres infectadas por Zika durante el embarazo. Se recomienda realizar la prueba de reaccion en cadena de la polimerasa mediante transcriptasa inversa para detectar ARN virico y pruebas serologicas (IgM ELISA y anticuerpos neutralizantes) para confirmar una infeccion por Zika. El diagnostico diferencial incluye la infeccion por virus dengue y chikungunya. Conclusiones. Existe un conocimiento limitado sobre los mecanismos patogenicos implicados y las consecuencias a largo plazo de la infeccion por virus Zika en adultos y recien nacidos.

  17. Engineered 3D bioimplants using elastomeric scaffold, self-assembling peptide hydrogel, and adipose tissue-derived progenitor cells for cardiac regeneration

    PubMed Central

    Soler-Botija, Carolina; Bagó, Juli R; Llucià-Valldeperas, Aida; Vallés-Lluch, Ana; Castells-Sala, Cristina; Martínez-Ramos, Cristina; Fernández-Muiños, Teresa; Chachques, Juan Carlos; Pradas, Manuel Monleón; Semino, Carlos E; Bayes-Genis, Antoni

    2014-01-01

    Contractile restoration of myocardial scars remains a challenge with important clinical implications. Here, a combination of porous elastomeric membrane, peptide hydrogel, and subcutaneous adipose tissue-derived progenitor cells (subATDPCs) was designed and evaluated as a bioimplant for cardiac regeneration in a mouse model of myocardial infarction. SubATDPCs were doubly transduced with lentiviral vectors to express bioluminescent-fluorescent reporters driven by constitutively active, cardiac tissue-specific promoters. Cells were seeded into an engineered bioimplant consisting of a scaffold (polycaprolactone methacryloyloxyethyl ester) filled with a peptide hydrogel (PuraMatrix™), and transplanted to cover injured myocardium. Bioluminescence and fluorescence quantifications showed de novo and progressive increases in promoter expression in bioactive implant-treated animals. The bioactive implant was well adapted to the heart, and fully functional vessels traversed the myocardium-bioactive implant interface. Treatment translated into a detectable positive effect on cardiac function, as revealed by echocardiography. Thus, this novel implant is a promising construct for supporting myocardial regeneration. PMID:24936221

  18. Numerical solving of equations in the work of José Mariano Vallejo

    NASA Astrophysics Data System (ADS)

    Pacheco Castelao, José-Miguel; Pérez-Fern; ández, F. Javier; Suárez Alemán, Carlos-Oswaldo

    2007-09-01

    The progress of Mathematics during the nineteenth century was characterised both by an enormous acquisition of new knowledge and by the attempts to introduce rigour in reasoning patterns and mathematical writing. Cauchy's presentation of Mathematical Analysis was not immediately accepted, and many writers, though aware of that new style, did not use it in their own mathematical production. This paper is devoted to an episode of this sort that took place in Spain during the first half of the century: It deals with the presentation of a method for numerically solving algebraic equations by José Mariano Vallejo, a late Spanish follower of the Enlightenment ideas, politician, writer, and mathematician who published it in the fourth (1840) edition of his book Compendio de Mathemáticas Puras y Mistas, claiming to have discovered it on his own. Vallejo's main achievement was to write down the whole procedure in a very careful way taking into account the different types of roots, although he paid little attention to questions such as convergence checks and the fulfilment of the hypotheses of Rolle's Theorem. For sure this lack of mathematical care prevented Vallejo to occupy a place among the forerunners of Computational Algebra.

  19. A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice

    PubMed Central

    Yoon, Young Mee; Lewis, Jamal S.; Carstens, Matthew R.; Campbell-Thompson, Martha; Wasserfall, Clive H.; Atkinson, Mark A.; Keselowsky, Benjamin G.

    2015-01-01

    Targeted delivery of self-antigens to the immune system in a mode that stimulates a tolerance-inducing pathway has proven difficult. To address this hurdle, we developed a vaccine based-approach comprised of two synthetic controlled-release biomaterials, poly(lactide-co-glycolide; PLGA) microparticles (MPs) encapsulating denatured insulin (key self-antigen in type 1 diabetes; T1D), and PuraMatrixTM peptide hydrogel containing granulocyte macrophage colony-stimulating factor (GM-CSF) and CpG ODN1826 (CpG), which were included as vaccine adjuvants to recruit and activate immune cells. Although CpG is normally considered pro-inflammatory, it also has anti-inflammatory effects, including enhancing IL-10 production. Three subcutaneous administrations of this hydrogel (GM-CSF/CpG)/insulin-MP vaccine protected 40% of NOD mice from T1D. In contrast, all control mice became diabetic. In vitro studies indicate CpG stimulation increased IL-10 production, as a potential mechanism. Multiple subcutaneous injections of the insulin containing formulation resulted in formation of granulomas, which resolved by 28 weeks. Histological analysis of these granulomas indicated infiltration of a diverse cadre of immune cells, with characteristics reminiscent of a tertiary lymphoid organ, suggesting the creation of a microenvironment to recruit and educate immune cells. These results demonstrate the feasibility of this injectable hydrogel/MP based vaccine system to prevent T1D. PMID:26279095

  20. U.S. Department of Energy FreedomCAR & Vehicle Technologies Program Oil Bypass Filter Technology Evaluation Fifth Quarterly Report October - December 2003

    SciTech Connect

    Larry Zirker; James Francfort

    2004-02-01

    This Oil Bypass Filter Technology Evaluation quarterly report (October-December 2003) details the ongoing fleet evaluation of an oil bypass filter technology by the Idaho National Engineering and Environmental Laboratory (INEEL) for the U.S. Department of Energy's FreedomCAR & Vehicle Technologies Program. Eight four-cycle diesel-engine buses used to transport INEEL employees on various routes have been equipped with oil bypass filter systems from the puraDYN Corporation. The bypass filters are reported to have engine oil filtering capability of <1 micron and a built-in additive package to facilitate extended oil-drain intervals. To date, the eight buses have accumulated 324,091 test miles. This represents an avoidance of 27 oil changes, which equate to 952 quarts (238 gallons) of new oil not conserved and therefore, 952 quarts of waste oil not generated. To validate the extended oil-drain intervals, an oil-analysis regime is used to evaluate the fitness of the oil for continued service by monitoring the presence of necessary additives, undesirable contaminants, and engine-wear metals. The test fleet has been expanded to include six Chevrolet Tahoe sport utility vehicles with gasoline engines.

  1. Oil Bypass Filter Technology Evaluation - Third Quarterly Report, April--June 2003

    SciTech Connect

    Laurence R. Zirker; James E. Francfort

    2003-08-01

    This Third Quarterly report details the ongoing fleet evaluation of an oil bypass filter technology by the Idaho National Engineering and Environmental Laboratory (INEEL) for the U.S. Department of Energy’s FreedomCAR & Vehicle Technologies Program. Eight full-size, four-cycle diesel-engine buses used to transport INEEL employees on various routes have been equipped with oil bypass filter systems from the PuraDYN Corporation. The reported engine lubricating oil-filtering capability (down to 0.1 microns) and additive package of the bypass filter system is intended to extend oil-drain intervals. To validate the extended oil-drain intervals, an oil-analysis regime monitors the presence of necessary additives in the oil, detects undesirable contaminants and engine wear metals, and evaluates the fitness of the oil for continued service. The eight buses have accumulated 185,000 miles to date without any oil changes. The preliminary economic analysis suggests that the per bus payback point for the oil bypass filter technology should be between 108,000 miles when 74 gallons of oil use is avoided and 168,000 miles when 118 gallons of oil use is avoided. As discussed in the report, the variation in the payback point is dependant on the assumed cost of oil. In anticipation of also evaluating oil bypass systems on six Chevrolet Tahoe sport utility vehicles, the oil is being sampled on the six Tahoes to develop an oil characterization history for each engine.

  2. Campo de velocidade peculiar na teoria linear

    NASA Astrophysics Data System (ADS)

    Pires, N.

    2003-08-01

    Aglomerados e superaglomerados de galáxias são responsáveis pela chamada velocidade peculiar (movimentos relativos à expansão pura do universo) das galáxias. A amplitude destas perturbações depende da densidade de matéria do universo e do contraste de densidade no interior do volume onde está localizada a galáxia. Em 1980, Peebles introduziu o fator "f", que relaciona a amplitude das perturbações da velocidade com o campo gravitacional peculiar, no contexto da teoria linear. No presente trabalho obtemos uma solução geral analítica para o fator "f" de Peebles do campo de velocidades peculiares, em termos de funções hipergeométricas, válida para qualquer geometria do universo. Como um teste de nossa solução, os resultados encontrados originalmente por Peebles em 1980 e os resultados mais gerais encontrados por O. Lahav e colaboradores em 1991, são reobtidos.

  3. Nonlocal Equations with Measure Data

    NASA Astrophysics Data System (ADS)

    Kuusi, Tuomo; Mingione, Giuseppe; Sire, Yannick

    2015-08-01

    We develop an existence, regularity and potential theory for nonlinear integrodifferential equations involving measure data. The nonlocal elliptic operators considered are possibly degenerate and cover the case of the fractional p-Laplacean operator with measurable coefficients. We introduce a natural function class where we solve the Dirichlet problem, and prove basic and optimal nonlinear Wolff potential estimates for solutions. These are the exact analogs of the results valid in the case of local quasilinear degenerate equations established by Boccardo and Gallouët (J Funct Anal 87:149-169, 1989, Partial Differ Equ 17:641-655, 1992) and Kilpeläinen and Malý (Ann Scuola Norm Sup Pisa Cl Sci (IV) 19:591-613, 1992, Acta Math 172:137-161, 1994). As a consequence, we establish a number of results that can be considered as basic building blocks for a nonlocal, nonlinear potential theory: fine properties of solutions, Calderón-Zygmund estimates, continuity and boundedness criteria are established via Wolff potentials. A main tool is the introduction of a global excess functional that allows us to prove a nonlocal analog of the classical theory due to Campanato (Ann Mat Pura Appl (IV) 69:321-381, 1965). Our results cover the case of linear nonlocal equations with measurable coefficients, and the one of the fractional Laplacean, and are new already in such cases.

  4. Purification and characterization of recombinant Plasmodium falciparum adenylosuccinate synthetase expressed in Escherichia coli.

    PubMed

    Jayalakshmi, R; Sumathy, K; Balaram, Hemalatha

    2002-06-01

    Most parasitic protozoa lack the de novo purine biosynthetic pathway and rely exclusively on the salvage pathway for their purine nucleotide requirements. Enzymes of the salvage pathway are, therefore, candidate drug targets. We have cloned the Plasmodium falciparum adenylosuccinate synthetase gene. In the parasite, adenylosuccinate synthetase is involved in the synthesis of AMP from IMP formed during the salvage of the purine base, hypoxanthine. The gene was shown to code for a functionally active protein by functional complementation in a purA mutant strain of Escherichia coli, H1238. This paper reports the conditions for hyperexpression of the recombinant protein in E. coli BL21(DE3) and purification of the protein to homogeneity. The enzyme was found to require the presence of dithiothreitol during the entire course of the purification for activity. Glycerol and EDTA were found to stabilize enzyme activity during storage. The specific activity of the purified protein was 1143.6 +/- 36.8 mUnits/mg. The K(M)s for the three substrates, GTP, IMP, and aspartate, were found to be 4.8 microM, 22.8 microM, and 1.4 mM, respectively. The enzyme was a dimer on gel filtration in buffers of low ionic strength but equilibrated between a monomer and a dimer in buffers of increased ionic strength.

  5. Reflected Phases Apparent in Local Event Seismograms at Uturuncu Volcano, Bolivia

    NASA Astrophysics Data System (ADS)

    Farrell, A. K.; McNutt, S. R.

    2014-12-01

    Uturuncu volcano is located in the central Andes at 22.27° S, 67.18° W. Despite 270,000 years of volcanic dormancy, a satellite geodetic InSAR survey by Pritchard and Simons (2002) shows an inflation rate of 1.5-2 cm/yr over an area with a width of 70 km (Pritchard and Simons, 2002). The source was modeled, using a Mogi source, to 15-17 km deep located ~3 km to the southwest of Uturuncu's summit. Current studies have found a source area of decreased density with respect to the crust and with a Vp/Vs ratio of > 1.9, with a depth matching that derived from the deformation signature [Potro et al., 2013; M.E. West, H. McFarlin, D. Christensen written comm.] Determining the size, geographic location, source depth, and source shape of deformation at Uturuncu volcano is important because this can indicate either (or a combination of) injection of magma from depth into the system, melting of crustal rock from a previous injection, or the build-up of pressure in a hydrothermal system (Pritchard and Simons, 2002). We are using phases arriving between the P and S phases to constrain some of the deformation source parameters. These result from the interaction of seismic waves with the attenuating source, believed to be local thickening of the regional shallow crustal magma body. Analysis of 200 local events spanning the period of PLUTONS seismic network operation (April 2010 to October 2012) reveals that 55 of these events show at least one station with a phase arrival between the P and S phases. If this trend holds as expected during analysis of the other 377 shallow local events, then 25.7% of the local events will generate an anomalous phase. No observable differences in the frequency of phase occurrence have been noted with time; however, the locations of earthquakes generating this phase strongly cluster (39 of 55) within a 10 km radius of the volcano, skewed to the south and west. There is the possibility of a NE-SW trend between the earthquake epicenter and the

  6. Geologic map of Great Sand Dunes National Park, Colorado

    USGS Publications Warehouse

    Madole, Richard F.; VanSistine, D. Paco; Romig, Joseph H.

    2016-10-20

    Geologic mapping was begun after a range fire swept the area of what is now the Great Sand Dunes National Park in April 2000. The park spans an area of 437 square kilometers (or about 169 square miles), of which 98 percent is blanketed by sediment of Quaternary age, the Holocene and Pleistocene Epochs; hence, this geologic map of the Great Sand Dunes National Park is essentially a surficial geologic map. These surficial deposits are diverse and include sediment of eolian (windblown), alluvial (stream and sheetwash), palustrine (wetlands and marshes), lacustrine (lake), and mass-wasting (landslides) origin. Sediment of middle and late Holocene age, from about 8,000 years ago to the present, covers about 80 percent of the park.Fluctuations in groundwater level during Holocene time caused wetlands on the nearby lowland that bounds the park on the west to alternately expand and contract. These fluctuations controlled the stability or instability of eolian sand deposits on the downwind (eastern) side of the lowland. When groundwater level rose, playas became lakes, and wet or marshy areas formed in many places. When the water table rose, spring-fed streams filled their channels and valley floors with sediment. Conversely, when groundwater level fell, spring-fed streams incised their valley floors, and lakes, ponds, and marshes dried up and became sources of windblown sand.Discharge in streams draining the west flank of the Sangre de Cristo Range is controlled primarily by snowmelt and flow is perennial until it reaches the mountain front, beyond which streams begin losing water at a high rate as the water soaks into the creek beds. Even streams originating in the larger drainage basins, such as Sand and Medano Creeks, generally do not extend much more than 4 km (about 2.5 miles) beyond where they exit the mountains.The Great Sand Dunes contain the tallest dunes (maximum height about 750 feet, or 230 m) in North America. These dunes cover an area of 72 square kilometers

  7. EFFECTS OF OATS ON LIPID PROFILE, INSULIN RESISTANCE AND WEIGHT LOSS.

    PubMed

    Schuster, Jessica; Benincá, Gabriela; Vitorazzi, Renata; Morelo Dal Bosco, Simone

    2015-11-01

    Introducción: las enfermedades cardiovasculares son la principal causa mundial de morbilidad y mortalidad. Esta prevalencia justifica la importancia de los alimentos funcionales que promueven la salud cardiovascular, como el -glucano, presente en la avena, con potenciales efectos hipocolesterolémicos e hipoglucemiantes. Objetivo: evaluar los efectos de una intervención con la harina de avena en los niveles de glucosa en sangre, el índice HOMA-IR, el perfil de lípidos, el peso y el índice de masa corporal (IMC) de los usuarios adultos de un servicio de salud en Río Grande do Sul, Brasil. Métodos: estudio longitudinal, controlado, realizado con personas de 22-60 años de edad, usuarios de un servicio de salud. Los individuos fueron asignados al grupo control (dieta habitual) o grupo Case (dieta habitual + 40 g de avena/día). Al inicio del estudio y después de ocho semanas de seguimiento se evaluaron el peso y la altura, calculado IMC, la sangre recolectada para la medición de glucemia en ayunas, insulina, triglicéridos, colesterol total y colesterol HDL; y se calculó el colesterol LDL y el índice HOMA-IR. Los datos se expresan como media ± desviación estándar y porcentajes. Se aplicaron el test Kolmogorov-Smirnov, la t de Student, el test Mann-Whitney y las pruebas de Wilcoxon. Se adoptó un nivel de significación del 5% (p < 0,05). Resultados: la muestra estuvo constituida por 82 sujetos, divididos en casos (n = 38) y controles (n = 44) con una edad media de 40,07 ± 10,49 años, 58,5% mujeres. Comparando los resultados de todos los parámetros medidos al inicio del estudio y después de ocho semanas de seguimiento, el grupo de control no obtuvo una reducción significativa en ningún parámetro, mostrando un aumento significativo de la glucosa en sangre y HOMA-IR (p < 0,05). El grupo de intervención obtuvo una reducción significativa de todos los indicadores antropométricos y bioquímicos analizados (p < 0,001). Conclusión: los resultados

  8. Geologic map of Great Sand Dunes National Park, Colorado

    USGS Publications Warehouse

    Madole, Richard F.; VanSistine, D. Paco; Romig, Joseph H.

    2016-10-20

    Geologic mapping was begun after a range fire swept the area of what is now the Great Sand Dunes National Park in April 2000. The park spans an area of 437 square kilometers (or about 169 square miles), of which 98 percent is blanketed by sediment of Quaternary age, the Holocene and Pleistocene Epochs; hence, this geologic map of the Great Sand Dunes National Park is essentially a surficial geologic map. These surficial deposits are diverse and include sediment of eolian (windblown), alluvial (stream and sheetwash), palustrine (wetlands and marshes), lacustrine (lake), and mass-wasting (landslides) origin. Sediment of middle and late Holocene age, from about 8,000 years ago to the present, covers about 80 percent of the park.Fluctuations in groundwater level during Holocene time caused wetlands on the nearby lowland that bounds the park on the west to alternately expand and contract. These fluctuations controlled the stability or instability of eolian sand deposits on the downwind (eastern) side of the lowland. When groundwater level rose, playas became lakes, and wet or marshy areas called cienegas formed in many places. When the water table rose, spring-fed streams filled their channels and valley floors with sediment. Conversely, when groundwater level fell, spring-fed streams incised their valley floors, and lakes, ponds, and marshes dried up and became sources of windblown sand.Discharge in streams draining the west flank of the Sangre de Cristo Range is controlled primarily by snowmelt and flow is perennial until it reaches the mountain front, beyond which streams begin losing water at a high rate as the water soaks into the creek beds. Even streams originating in the larger drainage basins, such as Sand and Medano Creeks, generally do not extend much more than 4 km (about 2.5 miles) beyond where they exit the mountains.The Great Sand Dunes contain the tallest dunes (maximum height about 750 feet, or 230 m) in North America. These dunes cover an area of 72

  9. [Seroprevalence of antinuclear antibodies in blood donors in the Yaqui Valley].

    PubMed

    Serrano-Osuna, Ricardo; López-López, Rocío Milagro; Brito-Zurita, Olga Rosa; Sabag-Ruiz, Enrique; Pérez-Fernández, Héctor; Ornelas-Aguirre, José Manuel

    2014-01-01

    Antecedentes: los anticuerpos antinucleares son inmunoglobulinas que reconocen componentes celulares nucleares y citoplasmáticos autólogos. En personas sanas no se relacionan con alguna enfermedad autoinmune; sin embargo, pueden estar vinculados con un fenotipo inmunológico de riesgo que no ha sido suficientemente estudiado. Objetivo: examinar la existencia de anticuerpos antinucleares en el suero de donadores de sangre. Material y métodos: estudio transversal y analítico en búsqueda de anticuerpos antinucleares en suero mediante inmunofluorescencia indirecta en células HEp-2. La prevalencia y patrón de expresión se contrastaron con la edad, el género y los antecedentes de enfermedad reumática o tiroidea. Resultados: se estudiaron 379 donadores de sangre con límites de edad entre 18 y 65 años. La prevalencia de anticuerpos antinucleares en la población estudiada fue de 13%. La mayoría de los sujetos positivos tenía entre 21 y 40 años de edad. El género masculino expresó mayor proporción de positividad (11%) en comparación con las mujeres (2%). De la misma forma, 82% de los hombres tenía títulos bajos (1:80) y en 66% eran de tipo nucleolar (RM = 10.66 [1.83 a 62.18]; p = 0.007). Conclusiones: en individuos sanos, la existencia de anticuerpos antinucleares a títulos bajos puede no significar un estado de autoinmunidad; sin embargo, podría ser el reflejo de una exposición a factores ambientales que no han sido lo suficientemente estudiados. Es necesario realizar nuevos estudios en población sana que permitan explicar la asociación entre estos anticuerpos y los factores tóxicoambientales, así como sus efectos en la salud.

  10. Evolution of Topography in Glaciated Mountain Ranges

    NASA Technical Reports Server (NTRS)

    Brocklehurst, Simon H.

    2002-01-01

    This thesis examines the response of alpine landscapes to the onset of glaciation. The basic approach is to compare fluvial and glacial laudscapes, since it is the change from the former to the latter that accompanies climatic cooling. This allows a detailed evaluation of hypotheses relating climate change to tectonic processes in glaciated mountain belts. Fieldwork was carried out in the eastern Sierra Nevada, California, and the Sangre de Cristo Range, Colorado, alongside digital elevation model analyses in the western US, the Southern Alps of New Zealand, and the Himalaya of northwestern Pakistan. hypothesis is overstated in its appeal to glacial erosion as a major source of relief production and subsequent peak uplift. Glaciers in the eastern Sierra Nevada and the western Sangre de Cristos have redistributed relief, but have produced only modest relief by enlarging drainage basins at the expense of low-relief topography. Glaciers have lowered valley floors and ridgelines by similar amounts, limiting the amount of "missing mass' that can be generated, and causing a decrease in drainage basin relief. The principal response of glaciated landscapes to rapid rock uplift is the development of towering cirque headwalls. This represents considerable relief production, but is not caused by glacial erosion alone. Large valley glaciers can maintain their low gradient regardless of uplift rate, which supports the "glacial buzzsaw" hypothesis. However, the inability of glaciers to erode steep hillslopes as rapidly can cause mean elevations to rise. Cosmogenic isotope dating is used to show that (i) where plucking is active, the last major glaciation removed sufficient material to reset the cosmogenic clock; and (ii) former glacial valley floors now stranded near the crest of the Sierra Nevada are at varying stages of abandonment, suggesting a cycle of drainage reorganiszation and relief inversion due to glacial erosion similar to that observed in river networks. Glaciated

  11. Serum Zn levels in dysphagic patients who underwent endoscopic gastrostomy for long term enteral nutrition.

    PubMed

    Santos, Carla Adriana; Fonseca, Jorge; Brito, José; Fernandes, Tânia; Gonçalves, Luísa; Sousa Guerreiro, António

    2014-02-01

    Objetivos: Pacientes con disfagia sometidos a Gastrostomía Endoscópica (PEG) presentan malnutrición calórico- proteica, mas poco se conoce acerca da malnutrición en micronutrientes. El objetivo del presente trabajo fue el estudio del zinc sérico en pacientes portadores de PEG y su relación con proteínas séricas, zinc de sangre total y enfermedades de base. Métodos: De los pacientes portadores de PEG se ha obtenido antes del procedimiento. La determinación del zinc del suero y total se ha obtenido por lo método Wavelength Dispersive X-ray Fluorescence Spectroscopy. Fueron consideradas la albumina y la transferrina. Se estudiaron pacientes como un todo y se dividieron en: cáncer de cabeza y cuello (CCC) y enfermedad neurológica (EN). Resultados: 32 pacientes (22 hombres), 43-88 años: CCC = 15, EN = 17. La mayoría (30/32) presento lo zinc en suero bajo. Solo dos, con lesión cerebral traumática, tenían valores normales de zinc. En la sangre total, 17/32 estaban dentro del rango normal. Sin diferencias entre los grupos CCC-EN. Sin asociación entre lo zinc sérico y la albumina o transferrina. Sin asociación entre lo zinc en suero y total. Conclusiones: los enfermos presentaran zinc sérico bajo no momento de la PEG, relacionado con el ayuno prolongado y no con la enfermedad subyacente. La reducción del zinc sérico no está relacionada con las proteínas. Lo zinc sérico fue más sensible para la identificación de reducción de la ingesta. Los grupos que se ocupan de enfermos con PEG deben incluir la determinación del zinc en la evaluación o incluir el suministro de zinc.

  12. Obesity and metabolic surgery in type 1 diabetes mellitus.

    PubMed

    Raab, Heike; Weiner, R A; Frenken, M; Rett, K; Weiner, S

    2013-03-01

    Introducción: La cirugía de la obesidad es un método eficaz para el tratamiento de la obesidad y la diabetes mellitus tipo 2. Este tipo de diabetes puede se resuelve por completo en el 78,1% de los pacientes diabéticos y mejora en el 86,6% de los pacientes diabéticos. Sin embargo, poco se sabe acerca de la cirugía bariátrica en la diabetes mellitus tipo 1. Métodos: Presentamos 6 pacientes mujeres obesas con diabetes mellitus tipo 1 que se sometieron a cirugía bariátrica. Dos de ellas fueron sometidas a un bypass gástrico en-Y-Roux (BPGYR), una se le realizó una gastrectomía en manga y a las tres restantes una derivación biliopancreática con-switch duodenal (DBP-SD). Resultados: Nuestros resultados mostraron una reducción de peso notable, así como una mejora en el control de la glucosa en sangre y el requerimiento de insulina en los años de seguimiento después de la cirugía. El IMC prequirúrgico de las 6 pacientes osciló entre 37,3-46,0 kg/m2 y mejoró a 25,8-29,0 kg/m2 un año después de la cirugía. La HbA1c disminuyó de 6,7-9,8% antes de la cirugía a 5,7-8,5% un año después de la cirugía. El requerimiento diario de insulina se redujo de 62-150 UI/día antes de la cirugía a 15-54 UI /día al cabo de un año. Conclusión: Los resultados son impresionantes y muestran una mejora en la sensibilidad a la insulina tras una cirugía de la obesidad. No obstante, un control óptimo de la glucosa de sangre sigue siendo muy importante en la terapia de la diabetes mellitus tipo 1 para evitarcomplicaciones a largo plazo.

  13. Preliminary Geologic Map of the Sanchez Reservoir Quadrangle and Eastern Part of the Garcia Quadrangle, Costilla County, Colorado

    USGS Publications Warehouse

    Thompson, Ren A.; Machette, Michael N.; Drenth, Benjamin J.

    2007-01-01

    This geologic map is based entirely on new mapping by Thompson and Machette, whereas the geophysical data and interpretations were supplied by Drenth. The map area includes most of San Pedro Mesa, a basalt covered mesa that is uplifted as a horst between the Southern Sangre de Cristo fault zone (on the west) and the San Luis fault zone on the east. The map also includes most of the Sanchez graben, a deep structural basin that lies between the San Luis fault zone (on the west) and the Central Sangre de Cristo fault zone on the east. The oldest rocks in the map area are Proterozoic granites and Paleozoic sedimentary rocks, which are only exposed in a small hill on the west-central part of the mesa. The low hills that rise above San Pedro mesa are comprised of middle(?) Miocene volcanic rocks that are undated, but possibly correlative with mapped rocks to the east of Sanchez Reservoir. The bulk of the map area is comprised of the Servilleta Basalt, a regional series of flood basalts of Pliocene age. The west, north, and northeast margins of the mesa are covered by extensive landslide deposits that rest on poorly exposed sediment of the Santa Fe Group. Rare exposures of the sediment are comprised of siltstones, sandstones, and minor fluvial conglomerates. Most of the low ground surrounding the mesa is covered by surficial deposits of Quaternary age. The piedmont alluvium is subdivided into three Pleistocene units, and three Holocene units. The oldest Pleistocene gravel (unit Qao) forms an extensive coalesced alluvial fan and piedmont surface that is known as the Costilla Plains. This surface extends west from San Pedro Mesa to the Rio Grande. The primary geologic hazards in the map are are from earthquakes and landslides. There are three major fault zones in the area (as discussed above), and they all show evidence for late Pleistocene to possible Holocene movement. Two generations of landslides are mapped (younger and older), and both may have seismogenic origins.

  14. On the assimilation of SWOT type data into 2D shallow-water models

    NASA Astrophysics Data System (ADS)

    Frédéric, Couderc; Denis, Dartus; Pierre-André, Garambois; Ronan, Madec; Jérôme, Monnier; Jean-Paul, Villa

    2013-04-01

    In river hydraulics, assimilation of water level measurements at gauging stations is well controlled, while assimilation of images is still delicate. In the present talk, we address the richness of satellite mapped information to constrain a 2D shallow-water model, but also related difficulties. 2D shallow models may be necessary for small scale modelling in particular for low-water and flood plain flows. Since in both cases, the dynamics of the wet-dry front is essential, one has to elaborate robust and accurate solvers. In this contribution we introduce robust second order, stable finite volume scheme [CoMaMoViDaLa]. Comparisons of real like tests cases with more classical solvers highlight the importance of an accurate flood plain modelling. A preliminary inverse study is presented in a flood plain flow case, [LaMo] [HoLaMoPu]. As a first step, a 0th order data processing model improves observation operator and produces more reliable water level derived from rough measurements [PuRa]. Then, both model and flow behaviours can be better understood thanks to variational sensitivities based on a gradient computation and adjoint equations. It can reveal several difficulties that a model designer has to tackle. Next, a 4D-Var data assimilation algorithm used with spatialized data leads to improved model calibration and potentially leads to identify river discharges. All the algorithms are implemented into DassFlow software (Fortran, MPI, adjoint) [Da]. All these results and experiments (accurate wet-dry front dynamics, sensitivities analysis, identification of discharges and calibration of model) are currently performed in view to use data from the future SWOT mission. [CoMaMoViDaLa] F. Couderc, R. Madec, J. Monnier, J.-P. Vila, D. Dartus, K. Larnier. "Sensitivity analysis and variational data assimilation for geophysical shallow water flows". Submitted. [Da] DassFlow - Data Assimilation for Free Surface Flows. Computational software http

  15. Molecular characterization of virulence genes of Streptococcus equi subsp. equi and Streptococcus equi subsp. zooepidemicus in equines

    PubMed Central

    Javed, R.; Taku, A. K.; Gangil, Rakhi; Sharma, R. K.

    2016-01-01

    Aim: The aim was to determine the occurrence of streptococci in equines in Jammu (R. S. Pura, Katra), characterization of Streptococci equi subsp. equi and Streptococcus equi subsp. zooepidemicus with respect to their virulence traits and to determine antibiotic sensitivity pattern of virulent Streptococcus isolates. Materials and Methods: A total of 96 samples were collected from both clinically affected animals (exhibiting signs of respiratory tract disease) and apparently healthy animals and were sent to laboratory. The organisms were isolated on Columbia nalidixic acid agar containing 5% sheep blood as well as on sheep blood agar and confirmed by cultural characteristics and biochemical tests. Molecular detection of Streptococcus was done directly from cultures using sodA and seM gene-based polymerase chain reaction (PCR). Antibiogram was performed against five antibiotics such as amoxicillin, penicillin G, streptomycin, rifampicin, and methicillin. Results: During this study, a total 40 streptococcal isolates were obtained out of which 2 isolates were of S. equi subsp. equi, 12 isolates were from S. equi subsp. zooepidemicus. In the PCR-based detection, we revealed amplicons of 235 bp and 679 bp for confirmation of sodA and seM gene, respectively. In antibiogram, two isolates of S. equi subsp. equi were found resistant to penicillin G, and all other isolates were found sensitive to amoxicillin and streptomycin. Conclusion: The majority of streptococcal infections was due to S. equi subsp. Zooepidemicus, and thus was recognized as a potential pathogen of diseases of equines besides S. equi subsp. equi. PMID:27651677

  16. Oil Bypass Filter Technology Evaluation, Eighth Quarterly Report, July - September 2004

    SciTech Connect

    Larry Zirker; James Francfort; Jordan Fielding

    2004-11-01

    This Oil Bypass Filter Technology Evaluation quarterly report (July--September 2004) details the ongoing fleet evaluation of an oil bypass filter technology being conducted by the Idaho National Engineering and Environmental Laboratory (INEEL) for the U.S. Department of Energy’s (DOE) FreedomCAR & Vehicle Technologies Program. Eight INEEL four-cycle diesel engine buses used to transport INEEL employees on various routes and six INEEL Chevrolet Tahoes with gasoline engines are equipped with oil bypass filter systems from the puraDYN Corporation. The bypass filters are reported to have engine oil filtering capability of <1 micron and a built-in additive package to facilitate extended oil-drain intervals. This quarter, the eight diesel engine buses traveled 82,123 miles. As of the end of September 2004, they had accumulated 580,848 miles since the beginning of the test and 516,401 miles without an oil change. This represents an avoidance of 43 oil changes, which equates to 1,505 quarts (376 gallons) of new oil not consumed and, furthermore, 1,505 quarts of waste oil not generated. Two buses had their oil changed this quarter due to the degraded quality of the engine oil, as determined by the low total base numbers. This quarter, the six Tahoe test vehicles traveled 40,762 miles. As of the end of September 2004, the six Tahoes have accumulated 150,205 total test miles. The Tahoe filter test is in flux because of the engine cleaning or flushing that is occurring. The recycled oil used initially in the Tahoe testing was replaced with a 10W-30 Castrol oil, however only three vehicles have been flushed (one servicing event with the new oil) and restarted on testing.

  17. A household survey to assess community knowledge, attitude and practices on malaria in a rural population of Northern India

    PubMed Central

    Gupta, Rajiv Kumar; Raina, Sunil Kumar; Shora, Tajali N.; Jan, Rayaz; Sharma, Renu; Hussain, Shahid

    2016-01-01

    Introduction: An extensive search on PubMed reveals very little in terms of evidence regarding the current knowledge, attitude, and practices (KAP) of the population in general and rural population, in particular, in this part of the country. Therefore, a study was conducted with the aim to assess the communities’ knowledge of malaria transmission, recognition of signs and symptoms, treatment seeking. Materials and Methods: A stratified two-stage design was used to conduct a house-to-house survey using a semi-structured questionnaire in RS Pura block of Jammu District of Jammu and Kashmir State in North India. Results: A total of 300 households were included in the study. However, data on 4 households was found to be incomplete at the time of analysis and, therefore, were excluded. Out of 296 study participants interviewed 65.5% were males, while 34.5% females. All of the study participants (100%) had heard of malaria, and the main source of their information was television/newspaper. 92.5% of the study population considered malaria to be a serious health problem, thus reflecting their attitude to the disease. Regarding practices, 71.6% of the study participants preferred going to doctors at government hospitals for malaria treatment, and 56% were willing to seek medical help in <24 h in case of a child has a febrile episode. Conclusions: Results revealed that KAP among respondents were reasonably good and key sociocultural, and related indicators need to be identified as a part of malaria elimination strategy. PMID:27453852

  18. Genome-Wide Identification of Genes Required for Fitness of Group A Streptococcus in Human Blood

    PubMed Central

    Le Breton, Yoann; Mistry, Pragnesh; Valdes, Kayla M.; Quigley, Jeffrey; Kumar, Nikhil; Tettelin, Hervé

    2013-01-01

    The group A streptococcus (GAS) is a strict human pathogen responsible for a wide spectrum of diseases. Although GAS genome sequences are available, functional genomic analyses have been limited. We developed a mariner-based transposon, osKaR, designed to perform Transposon-Site Hybridization (TraSH) in GAS and successfully tested its use in several invasive serotypes. A complex osKaR mutant library in M1T1 GAS strain 5448 was subjected to negative selection in human blood to identify genes important for GAS fitness in this clinically relevant environment. Mutants underrepresented after growth in blood (output pool) compared to growth in rich media (input pool) were identified using DNA microarray hybridization of transposon-specific tags en masse. Using blood from three different donors, we identified 81 genes that met our criteria for reduced fitness in blood from at least two individuals. Genes known to play a role in survival of GAS in blood were found, including those encoding the virulence regulator Mga (mga), the peroxide response regulator PerR (perR), and the RofA-like regulator Ralp-3 (ralp3). We also identified genes previously reported for their contribution to sepsis in other pathogens, such as de novo nucleotide synthesis (purD, purA, pyrB, carA, carB, guaB), sugar metabolism (scrB, fruA), zinc uptake (adcC), and transcriptional regulation (cpsY). To validate our findings, independent mutants with mutations in 10 different genes identified in our screen were confirmed to be defective for survival in blood bactericidal assays. Overall, this work represents the first use of TraSH in GAS to identify potential virulence genes. PMID:23297387

  19. Identification of polypeptides encoded by an Escherichia coli locus (hflA) that governs the lysis-lysogeny decision of bacteriophage lambda.

    PubMed Central

    Banuett, F; Herskowitz, I

    1987-01-01

    We report the cloning of the Escherichia coli hflA locus, which governs stability of phage lambda cII protein and which has been proposed to encode or regulate a cII-specific protease. The hflA locus was cloned on an 18-kilobase DNA fragment by selecting for plasmids that carry the neighboring purA gene. The boundaries of hflA were delimited by analysis of deletions and insertions constructed in vitro and by use of transposon Tn1000. Maxicell analysis of the proteins encoded by the hflA-containing fragment shows that hflA consists of at least two nonoverlapping genes, hflC and hflK, encoding polypeptides of 37,000 (C) and 46,000 (K) daltons. We observe that insertions into one gene eliminate the corresponding polypeptide and greatly reduce synthesis of the other. We suggest that these two polypeptides (K and C) interact to form a multimeric complex and that free subunits are unstable. We have constructed two types of fusions between hflA and lacZ. One is an hflC-lacZ protein fusion constructed in vitro; the other is an hfl-lacZ operon fusion in which a Mu dX(Apr lac) has inserted into the hflK gene. We have used the operon fusion to infer the direction of transcription of the hflK gene--toward hflC and in the same direction as hflC. Last, we describe evidence that hflA contains an additional gene, hflX, encoding a 50,000-dalton polypeptide. Images PMID:3040675

  20. Longitudinal prevalence, faecal shedding and molecular characterisation of Campylobacter spp. and Salmonella enterica in sheep.

    PubMed

    Yang, Rongchang; Jacobson, Caroline; Gardner, Graham; Carmichael, Ian; Campbell, Angus J D; Ryan, Una

    2014-11-01

    Faecal excretion of Campylobacter spp. and Salmonella enterica in sheep in Australia was determined using a quantitative multiplex PCR (qPCR) targeting the Campylobacter spp. purine biosynthesis gene (PurA) and the S. enterica outer membrane protein (ompF). The mutiplex qPCR was specific and Campylobacter spp. and S. enterica were each detected with a sensitivity of 5 organisms/µL faecal DNA extract. This multiplex qPCR was used to determine the prevalence and concentration of Campylobacter spp. and S. enterica in 3412 faecal samples collected from 1189 lambs on eight farms across South Australia (n = 2 farms), New South Wales (n = 1), Victoria (n = 2) and Western Australia (n = 3) at three sampling periods (weaning, post-weaning and pre-slaughter). The overall prevalences of Campylobacter spp. and S. enterica were 13.3% and 5.0%, respectively, with the highest prevalence for Campylobacter spp. in South Australia and the highest prevalence for S. enterica in New South Wales. Campylobacter jejuni was the only Campylobacter sp. identified from a subset of 120 positive samples sequenced at the 16S locus. S. enterica serovar Typhimurium was the only serovar of S. enterica identified from a subset of 120 positive samples sequenced at the ompF locus. Across all states, Campylobacter spp. had the highest median bacterial concentration in faeces at weaning and post-weaning (medians of 3.4 × 10(6) and 1.1 × 10(5), respectively), whereas S. enterica had the highest median bacterial concentration at pre-slaughter (1.8 × 10(5)/g faeces).

  1. Geologic map of the Alamosa 30’ × 60’ quadrangle, south-central Colorado

    USGS Publications Warehouse

    Thompson, Ren A.; Shroba, Ralph R.; Michael N. Machette,; Fridrich, Christopher J.; Brandt, Theodore R.; Cosca, Michael A.

    2015-10-15

    The Alamosa 30'× 60' quadrangle is located in the central San Luis Basin of southern Colorado and is bisected by the Rio Grande. The Rio Grande has headwaters in the San Juan Mountains of Colorado and ultimately discharges into the Gulf of Mexico 3,000 kilometers (km) downstream. Alluvial floodplains and associated deposits of the Rio Grande and east-draining tributaries, La Jara Creek and Conejos River, occupy the north-central and northwestern part of the map area. Alluvial deposits of west-draining Rio Grande tributaries, Culebra and Costilla Creeks, bound the Costilla Plain in the south-central part of the map area. The San Luis Hills, a northeast-trending series of flat-topped mesas and hills, dominate the landscape in the central and southwestern part of the map and preserve fault-bound Neogene basin surfaces and deposits. The Precambrian-cored Sangre de Cristo Mountains rise to an elevation of nearly 4,300 meters (m), almost 2,000 m above the valley floor, in the eastern part of the map area. In total, the map area contains deposits that record surficial, tectonic, sedimentary, volcanic, magmatic, and metamorphic processes over the past 1.7 billion years.

  2. Application of remote sensor data to geologic analysis of the Bonanza test site, Colorado

    NASA Technical Reports Server (NTRS)

    Lee, K. (Principal Investigator)

    1976-01-01

    The author has identified the following significant results. The Hayden Pass (Orient mine area) includes 60 sq miles of the northern Sangre de Cristo Mountains and San Luis Valley in south-central Colorado. Based on interpretation of the remote sensor data, a geologic map was prepared and compared with a second geologic map, prepared from interpretation of both remote sensor data and field data. Comparison of the two maps gives an indication of the usefulness and reliability of the remote sensor data. The relative utility of color and color infrared photography was tested. The photography was used successfully to locate 75% of all faults in a portion of the geologically complex Bonanza volcanic center and to map and correctly identify 93% of all quaternary deposits and 62% of all areas of tertiary volcanic outcrop. Using a filter wheel photometer, more than 8,600 measurements of band reflectance of several sedimentary rocks were performed. The following conclusions were drawn: (1) the typical spectral reflectance curve shows a gradual increase with increasing wavelength; (2) the average band reflectance is about 0.20; and (3) within a formation, the minimum natural variation is about 0.04, or about 20% of the mean band reflectance.

  3. [Clinical analysis of 200 cases of idiopathic thrombocytopenic purpura].

    PubMed

    García-Stivalet, Lilia Adela; Muñoz-Flores, Aarón; Montiel-Jarquín, Alvaro José; Barragán-Hervella, Rodolfo Gregorio; Bejarano-Huertas, Ruth; García-Carrasco, Mario; López-Colombo, Aurelio

    2014-01-01

    INTRODUCCIÓN: la púrpura trombocitopénica idiopática se caracteriza por la extravasación de sangre en el tejido subcutáneo, membranas, mucosas o piel, que puede generar manifestaciones clínicas de sangrado como lesiones equimóticas, petequias de aparición brusca, epistaxis, gingivorragia y complicaciones graves como hemorragia intracraneal, debido a destrucción plaquetaria mediada por anticuerpos dirigidos contra la superficie de las plaquetas. El objetivo de este informe es presentar las características clínicas de los pacientes con púrpura trombocitopénica idiopática en un hospital de tercer nivel de atención, con la finalidad de tener estadísticas para estudios analíticos posteriores. MÉTODOS: se realizó un estudio descriptivo de 200 pacientes atendidos en el servicio de hematología con diagnóstico de púrpura trombocitopénica idiopática. Se describen sus manifestaciones clínicas, el diagnóstico y el tratamiento médico y quirúrgico empleados.

  4. Geologic map of the Alamosa 30’ × 60’ quadrangle, south-central Colorado

    USGS Publications Warehouse

    Thompson, Ren A.; Shroba, Ralph R.; Michael N. Machette; Fridrich, Christopher J.; Brandt, Theodore R.; Cosca, Michael A.

    2015-01-01

    The Alamosa 30'× 60' quadrangle is located in the central San Luis Basin of southern Colorado and is bisected by the Rio Grande. The Rio Grande has headwaters in the San Juan Mountains of Colorado and ultimately discharges into the Gulf of Mexico 3,000 kilometers (km) downstream. Alluvial floodplains and associated deposits of the Rio Grande and east-draining tributaries, La Jara Creek and Conejos River, occupy the north-central and northwestern part of the map area. Alluvial deposits of west-draining Rio Grande tributaries, Culebra and Costilla Creeks, bound the Costilla Plain in the south-central part of the map area. The San Luis Hills, a northeast-trending series of flat-topped mesas and hills, dominate the landscape in the central and southwestern part of the map and preserve fault-bound Neogene basin surfaces and deposits. The Precambrian-cored Sangre de Cristo Mountains rise to an elevation of nearly 4,300 meters (m), almost 2,000 m above the valley floor, in the eastern part of the map area. In total, the map area contains deposits that record surficial, tectonic, sedimentary, volcanic, magmatic, and metamorphic processes over the past 1.7 billion years.

  5. [Three cases of Pallister-Killian syndrome].

    PubMed

    Toledo-Bravo de Laguna, Laura; del Campo-Casanelles, Miguel; Santana-Rodriguez, Alfredo; Santana-Artiles, Alexandre; Sebastian-Garcia, Irma; Cabrera-Lopez, José Carlos

    2014-01-16

    Introduccion. El sindrome de Pallister-Killian se caracteriza por discapacidad intelectual, hipotonia, retraso motor y un fenotipo caracteristico en el que destaca un aspecto facial tosco, alteraciones pigmentarias de la piel y alopecia bitemporal. Es frecuente que se asocie a crisis convulsivas y a malformaciones en otros organos y sistemas. Tiene como causa principal el mosaicismo para la tetrasomia del cromosoma 12p. Casos clinicos. Se presentan tres nuevos casos pediatricos afectos de esta rara entidad, se describen las caracteristicas clinicas y se realiza una revision de la bibliografia. Conclusiones. Debe resaltarse la importancia del conocimiento del sindrome para poder llevar a cabo su diagnostico, puesto que lo habitual es que, sin practicar la biopsia cutanea o el frotis de mucosa bucal, la anomalia cromosomica pasa desapercibida si se usan tecnicas citogeneticas clasicas. Hoy en dia, es posible realizar el diagnostico en sangre mediante array-CGH o array-SNP, si bien la posibilidad de encontrar la anomalia cromosomica depende del porcentaje de mosaicismo.

  6. [Chromosomal abnormalities in patients from Obstetrics and Gynaecology hospital].

    PubMed

    Hernández-Herrera, Ricardo Jorge; Rojas-Patlán, Luz; Garza-Pérez, Rosa María; Dávila-Rodríguez, Martha; Cortés-Gutiérrez, Elva Irene; García-Rodríguez, Emerson Odón; Hernández-Hernández, Roberto Raúl

    2014-01-01

    INTRODUCCIÓN: las anormalidades cromosómicas se presentan en 2 a 4 % de los recién nacidos y causan 20 % de las muertes en el primer año de vida. Su prevalencia es de uno por cada 500 a 1000 recién nacidos vivos. Pueden ser numéricas o estructurales y afectar a los cromosomas autosómicos o sexuales. Se presentan en 1 a 3 % de la población general y en 6 a 7 % de los individuos con anomalías congénitas. MÉTODOS: estudio descriptivo en el que se incluyeron todos los resultados citogenéticos de cariotipos tomados de sangre periférica de adultos y neonatos. Se evaluó la prevalencia de polimorfismos y alteraciones cromosómicas en derechohabientes del Hospital de Ginecoobstetricia 23 del Instituto Mexicano del Seguro Social, en Monterrey, Nuevo León.

  7. [Hypothyroidism incidence and thyrotropin serum levels in newborns].

    PubMed

    Topete-González, Luz Rosalba; Ramirez-Garcia, Sergio Alberto; Macías-López, Griselda Guadalupe; Troyo-Sanromán, Rogelio; Ramos-Ramírez, Irma Mirella; Elizondo-Rueda, María Elizabeth Margarita; Dávalos-Rodríguez, Nory; González-Gamez, Jaime Guillermo; Cabrera-Pivaral, Carlos Enrique

    2013-01-01

    Introducción: el hipotiroidismo congénito ocupa el tercer lugar de las enfermedades hereditarias subclínicas en México. Los neonatos con hipofunción total o parcial de la glándula tiroides presentan concentraciones altas de la tirotropina, lo que permite identificar los casos probables con riesgo para desarrollar hipotiroidismo mediante las pruebas de tamiz. El objetivo de esta investigación fue determinar la incidencia de hipotiroidismo congénito neonatal en los recién nacidos y establecer el valor de corte en el ensayo de la prueba de tamiz. Métodos: se procesaron 4049 muestras de sangre de cordón umbilical de recién nacidos. Se cuantificó la hormona estimulante de la tiroides mediante ELISA. A los niños con valores elevados se les realizó la prueba confirmatoria mediante ensayo inmunoenzimático de micropartículas. Resultados: se identificó una incidencia de hipotiroidismo de 1.2 por cada 1000 recién nacidos. El valor de corte para la hormona estimulante de la tiroides fue de 26.63 mUI/L en la prueba de tamiz. Conclusiones: los valores de la hormona estimulante de la tiroides mostraron una distribución diferente a los de otras investigaciones en población mexicana, así como una incidencia más elevada de hipotiroidismo.

  8. [Churg-Strauss abdominal manifestation].

    PubMed

    Suarez-Moreno, Roberto; Ponce-Pérez, Luis Virgilio; Margain-Paredes, Miguel Angel; Garza-de la Llave, Heriberto; Madrazo-Navarro, Mario; Espinosa-Álvarez, Arturo

    2014-01-01

    Antecedentes: la enfermedad de Churg-Strauss es poco común, idiopática, caracterizada por hipereosinofilia en sangre y tejidos, aunada a vasculitis sistémica en pacientes con antecedentes de asma o rinitis alérgica. Las manifestaciones gastrointestinales del síndrome de Churg Strauss se caracterizan por dolor abdominal, seguido de diarrea y hemorragia en 31-45% de los casos. Caso clínico: paciente masculino con antecedente de asma que acudió a consulta por abdomen agudo con probable apendicitis aguda; durante el protocolo de estudio se diagnosticó síndrome de Churg Strauss, con manifestaciones intestinales. Conclusión: el síndrome de Churg Strauss es una vasculitis poco frecuente que puede manifestarse con síntomas intestinales, como en este caso; es importante tenerlo en mente a la hora de los diagnósticos diferenciales. Existen pocos reportes con este síndrome asociado con abdomen agudo, todos ellos con mal pronóstico.

  9. [Arterial pathology in migraine: endothelial dysfunction and structural changes in the brain and systemic vasculature].

    PubMed

    Larrosa-Campo, Davinia; Ramón-Carbajo, César; Álvarez-Escudero, Rocío; Cernuda-Morollón, Eva; García-Cabo, Carmen; Pascual, Julio

    2015-10-01

    Introduccion. La fisiopatologia subyacente a la asociacion entre migraña y otras enfermedades vasculares sistemicas no aterotromboticas no se conoce con certeza. La disfuncion endotelial se ha propuesto como nexo comun. A su vez, la disfuncion endotelial se considera como precursora de cambios estructurales en las paredes arteriales. Objetivo. Revisar el conocimiento actual acerca de las alteraciones funcionales (disfuncion endotelial) y estructurales (rigidez arterial y cambios ateroescleroticos) del lecho arterial asociadas a la migraña. Desarrollo. Estudios de marcadores biologicos de disfuncion endotelial en sangre periferica, vasorreactividad sistemica y cerebral, calculo de indices de rigidez arterial y visualizacion directa de cambios macroscopicos en la pared arterial han mostrado diferencias entre pacientes con y sin migraña, asi como entre los distintos subtipos de migraña. Conclusiones. La disfuncion endotelial, como precursora de cambios estructurales a nivel arterial, se postula como sustrato de la patologia vascular asociada a la migraña. La alteracion de marcadores biologicos es sugestiva de disfuncion endotelial en los pacientes con migraña; sin embargo, la correlacion con estudios de vasorreactividad no permite establecer conclusiones definitivas. Los datos disponibles no permiten concluir que la migraña se asocie con alteraciones macroscopicas fuera del lecho arterial cerebral.

  10. Late glacial aridity in southern Rocky Mountains

    SciTech Connect

    Davis, O.K.; Pitblado, B.L.

    1995-09-01

    While the slopes of the present-day Colorado Rocky Mountains are characterized by large stands of subalpine and montane conifers, the Rockies of the late glacial looked dramatically different. Specifically, pollen records suggest that during the late glacial, Artemisia and Gramineae predominated throughout the mountains of Colorado. At some point between 11,000 and 10,000 B.P., however, both Artemisia and grasses underwent a dramatic decline, which can be identified in virtually every pollen diagram produced for Colorado mountain sites, including Como Lake (Sangre de Cristo Mountains), Copley Lake and Splains; Gulch (near Crested Butte), Molas Lake (San Juan Mountains), and Redrock Lake (Boulder County). Moreover, the same pattern seems to hold for pollen spectra derived for areas adjacent to Colorado, including at sites in the Chuska Mountains of New Mexico and in eastern Wyoming. The implications of this consistent finding are compelling. The closest modem analogues to the Artemisia- and Gramineae-dominated late-glacial Colorado Rockies are found in the relatively arid northern Great Basin, which suggests that annual precipitation was much lower in the late-glacial southern Rocky Mountains than it was throughout the Holocene.

  11. Rheology of rock glaciers: a preliminary assessment

    SciTech Connect

    Giardino, J.R.; Vitek, J.D.; Hoskins, E.R.

    1985-01-01

    Movement of rock debris under the influence of gravity, i.e., mass movement, generates a range of phenomena from soil creep, through solifluction,debris flows and rock glaciers to rock falls. Whereas the resultant forms of these phenomena are different, common elements in the mechanics of movement are utilized in the basic interpretation of the processes of formation. Measurements of morphologic variables provide data for deductive analyses of processes that operate too slowly to observe or for processes that generated relict phenomena. External and internal characteristics or rock glacier morphometry and measured rates of motion serve as the basis for the development of a rheological model to explain phenomena classified as rock glaciers. A rock glacier in the Sangre de Cristo Mountains of Southern Colorado, which exhibits a large number of ridges and furrows and lichen bare fronts of lobes, suggests present day movement. A strain-net established on the surface provides evidence of movement characteristics. These data plus morphologic and fabric data suggest two rheological models to explain the flow of this rock glacier. Model one is based upon perfect plastic flow and model two is based upon stratified fluid movement with viscosity changing with depth. These models permit a better understanding of the movement mechanics and demonstrate that catastrophic events and slow creep contribute to the morphologic characteristics of this rock glacier.

  12. Identification of minor secondary metabolites from the latex of Croton lechleri (Muell-Arg) and evaluation of their antioxidant activity.

    PubMed

    De Marino, Simona; Gala, Fulvio; Zollo, Franco; Vitalini, Sara; Fico, Gelsomina; Visioli, Francesco; Iorizzi, Maria

    2008-01-01

    Dragon's blood (Sangre de drago), a viscous red sap derived from Croton lechleri Muell-Arg (Euphorbiaceae), is extensively used by indigenous cultures of the Amazonian basin for its wound healing properties. The aim of this study was to identify the minor secondary metabolites and test the antioxidant activity of this sustance. A bioguided fractionation of the n-hexane, chloroform, n-butanol, and aqueous extracts led to the isolation of 15 compounds: three megastigmanes, four flavan-3-ols, three phenylpropanoids, three lignans, a clerodane, and the alkaloid taspine. In addition to these known molecules, six compounds were isolated and identified for the first time in the latex: blumenol B, blumenol C, 4,5-dihydroblumenol A, erythro-guaiacyl-glyceryl-beta-O-4'- dihydroconiferyl ether, 2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-propane-1,3-diol and floribundic acid glucoside. Combinations of spectroscopic methods ((1)H-, (13)C- NMR and 2D-NMR experiments), ESI-MS, and literature comparisons were used for compound identification. In vitro antioxidant activities were assessed by DPPH, total antioxidant capacity and lipid peroxidation assays. Flavan-3-ols derivatives (as major phenolic compounds in the latex) exhibited the highest antioxidant activity.

  13. [In Process Citation].

    PubMed

    Reyna, Nadia; Moreno Rojas, Rafael; Mendoza, Laura; Parra, Karla; Linares, Sergia; Reyna, Eduardo; Cámara Martos, Fernando

    2016-03-25

    Se ha estudiado el índice glicémico, la carga glicémica y el efecto de saciedad producido en adultos jóvenes (12 hombres y 8 mujeres) por el consumo de tres tipos de barritas nutricionales formuladas con proteínas lactoséricas (LS), caseínas (CS) o hidratos de carbono (HC) frente a un control (C). Los valores de glucemia en la sangre a los 30 min fueron significativamente mayores (p < 0,05) para la barra HC (129 ± 8 mg/dl) frente a las barras CS (103 ± 6 mg/dl) y LS (86 ± 8 mg/dl). Asimismo, también se encontraron diferencias estadísticamente significativas (p < 0,05) entre los índices glicémicos de los tres tipos de barras estudiadas (LS = 11,5 ± 3,9; CS = 40,7 ± 6,5; HC = 68,8 ± 13,0). Por otro lado, las barritas nutricionales formuladas con proteínas lácteas (LS y CS) muestran un efecto de saciedad mucho más intenso y prolongado que la formulada con hidratos de carbono (HC), lo que pone de manifiesto el potencial de estas proteínas para ser utilizadas en la formulación de productos para diabéticos y dietéticos.

  14. Colorado

    NASA Technical Reports Server (NTRS)

    2002-01-01

    An early-season snowfall accents the Rocky Mountains through western and central Colorado. This true-color image made from data collected by MODIS on October 26, 2001, highlights the contrast between various irrigated areas and the otherwise dry environment at the foothills of the Rockies. One such example is the city of Denver and its outlying suburbs, which can be seen best in the high-resolution image. In areas that would normally harbor drought-tolerant grasses, shrubs and trees, humans are living, watering their lawns, and farming; those watered, green areas differ substantially from the surrounding hues of brown. Numerous National Parks and Monuments dot the Southwestern U.S. The Great Sand Dunes National Monument is one such park. Running along the western base the Sangre de Cristo Range(just below the image's center), a subsection of the Rockies, the monument possesses some of the highest inland sand dunes in the U.S., with crests reaching over 700 feet.

  15. [In Process Citation].

    PubMed

    Reyna, Nadia; Moreno Rojas, Rafael; Mendoza, Laura; Parra, Karla; Linares, Sergia; Reyna, Eduardo; Cámara Martos, Fernando

    2016-01-01

    Se ha estudiado el índice glicémico, la carga glicémica y el efecto de saciedad producido en adultos jóvenes (12 hombres y 8 mujeres) por el consumo de tres tipos de barritas nutricionales formuladas con proteínas lactoséricas (LS), caseínas (CS) o hidratos de carbono (HC) frente a un control (C). Los valores de glucemia en la sangre a los 30 min fueron significativamente mayores (p < 0,05) para la barra HC (129 ± 8 mg/dl) frente a las barras CS (103 ± 6 mg/dl) y LS (86 ± 8 mg/dl). Asimismo, también se encontraron diferencias estadísticamente significativas (p < 0,05) entre los índices glicémicos de los tres tipos de barras estudiadas (LS = 11,5 ± 3,9; CS = 40,7 ± 6,5; HC = 68,8 ± 13,0). Por otro lado, las barritas nutricionales formuladas con proteínas lácteas (LS y CS) muestran un efecto de saciedad mucho más intenso y prolongado que la formulada con hidratos de carbono (HC), lo que pone de manifiesto el potencial de estas proteínas para ser utilizadas en la formulación de productos para diabéticos y dietéticos. PMID:27238803

  16. [ANTHROPOMETRIC INDICES AND ITS RELATIONSHIP WITH BIOCHEMICAL MARKERS IN WOMEN].

    PubMed

    Ortiz Rodríguez, Briseidy; De León Fierro, Lidia Guillermina; Carrasco Legleu, Claudia Esther

    2015-12-01

    Objetivo: analizar la relación entre indicadores antropométricos de adiposidad y algunos marcadores sanguíneos de riesgo para el desarrollo de enfermedades metabólicas en mujeres sanas con diferente peso corporal. Método: participaron 23 mujeres de 21,0 ± 2,9 años de edad. Se calculó su índice de masa corporal (IMC), índice cintura-cadera (ICC) y suma proporcional de seis pliegues (SP6P), por antropometría. Se determinaron glucosa y triglicéridos en sangre mediante técnica enzimática colorimétrica e insulina por ensayo inmunoenzimático. Se realizó estadística descriptiva y regresión lineal múltiple (backward). Resultados: solo el IMC demostró ser un factor predictor para las concentraciones de glucosa (p=0,000) y triglicéridos (p=0,000), mientras que el ICC pudo predecir mejor la insulina (p=0,000). Conclusiones: el exceso de peso corporal parece explicar el aumento de las concentraciones de glucosa y triglicéridos, mientras que la adiposidad central elevada puede influir en los niveles de insulina.

  17. Cancellous bone homograft storage with aluminium-polyethylene bags.

    PubMed

    Meana, A; Martinez, R; Cañal, P; Arriaga, M J; Román, F San; Llames, S; Orós, C; Moreno, A; Fernandez, C

    2006-01-01

    In order to transport and cryopreserve human tissues, it is essential to have an easy-to-use recipient where tissues can be kept in sterile conditions. Here we show the results obtained by using Macopharma's tissue freezing bags, an aluminium-polyethylene multilayer bag, in our tissue bank of the Centro Comunitario de Sangre y Tejidos de Asturias. Five hundred and twenty-seven cancellous bone homografts were obtained from hospitals located 120 km around our Bank. The homografts were submitted to bacteriological controls and sent to our bank in these bags. They were stored at -70 degrees C and sent in dry ice to about 50 hospitals, where the tissue was bacteriologically controlled and grafted. Furthermore, the behaviour of these bags at -140 degrees C (vapour nitrogen) or -196 degrees C (liquid nitrogen) was tested. Our results indicate that Macopharma aluminium-polyethylene bags are suitable for the transporting and cryopreserving of cancellous bone homografts. These bags could also be used for keeping tissues in nitrogen containers.

  18. [Performance of entero-insular axis in an athletic population: diet and exercise influence].

    PubMed

    Rodriguez, Carmen; Quezada-Feijoo, Maribel; Toro, Carmen; Barón-Esquivias, Gonzalo; Segura, Eduardo; Mangas, Alipio; Toro, Rocio

    2015-05-01

    Introducción: La relación existente entre el ejercicio físico y la regulación del apetito puede conducir a una mejora del rendimiento competitivo de los deportistas. Los mediadores del eje entero-insular generan señales neurohumorales que influyen en la regulación del apetito y la homeostasis energética. Objetivo: Determinar la influencia de la dieta y el ejercicio prolongado sobre los péptidos intestinales, grelina, resistina, leptina, e incretinas (GLP-1 y GIP) en una población deportista. MÉTODOS: Este es un estudio prospectivo, de intervención desarrollado desde Octubre 2012 a Marzo 2013. Se incluyeron 32 jugadores de rugby sanos. Se tomaron medidas antropométricas y muestras de sangre en el momento 0 y a los seis meses del estudio. Se distribuyeron aleatoriamente a una dieta bien proteica (DP) o mediterránea (DM) y estudiamos los niveles plasmáticos de adipoquinas e incretinas. Resultados: Las concentraciones plasmáticas de GLP- 1 y GIP presentaron un descenso (p.

  19. Relationships between serum calcium and magnesium levels and lipoproteins, homocysteine and insulin resistance/sensitivity markers at birth.

    PubMed

    Ziniewicz, Hanna K; Gesteiro, Eva; González-Muñoz, M José; Bastida, Sara; Sánchez-Muniz, Francisco J

    2014-01-01

    Introducción La relación entre los niveles de minerales en suero con los de homocisteína, lipoproteínas y marcadores homeostáticos de glucosa al nacimiento es poco conocida. El objetivo del presente estudio fue doble: a) determinar la relación entre calcio, magnesio, marcadores de riesgo de enfermedad cardiovascular (CVD) (p.e. lípidos, lipoproteínas, homocisteína) y marcadores de sensibilidad/resistencia a la insulina (p.e. glucosa, insulina, HOMA) en sangre de cordón; b) encontrar la posible influencia de los niveles elevados o reducidos de calcio y magnesio en suero sobre tales marcadores. Sujetos y Métodos Se testaron 48 recién nacidos a término, de parto eutócico, normopeso, peso adecuado para su edad gestacional, sin distrés fetal del Estudio Mérida. Se obtuvieron percentiles para calcio, magnesio y la relación Ca/Mg y se compararon los niveles de marcadores CVD y sensibilidad/resistencia a la insulina de los neonatos clasificados en el primer cuartil para calcio, magnesio y cociente Ca/Mg con aquellos del cuarto cuartil. Resultados El calcio sérico se correlacionó negativamente con HDL-c (p.

  20. [The cardiovagal, cardiosympathetic and vasosympathetic arterial baroreflexes and the neural control of short-term blood pressure].

    PubMed

    Robles-Cabrera, Adriana; Michel-Chávez, Anaclara; Callejas-Rojas, Rodolfo C; Malamud-Kessler, Caroline; Delgado, Guillermo; Estañol-Vidal, Bruno

    2014-12-01

    Introduccion. Los factores que modulan la presion arterial a corto plazo se encuentran puntualmente regulados para mantenerla dentro de valores de referencia. Esto se logra gracias a la existencia de mecanismos de autorregulacion, tanto humorales como nerviosos. Los mecanismos neurogenicos son reflejos y su resultado se observa en cambios de presion arterial de forma inmediata, latido a latido. Desarrollo. Los reflejos nerviosos cardiovasculares se encuentran mediados por los barorreceptores arteriales, a traves de los efectores cardiovagal, cardiosimpatico y vasosimpatico. El barorreceptor es estimulado cuando el volumen de sangre eyectado por el ventriculo distiende las paredes arteriales del seno carotideo y la aorta proximal y estimula los mecanorreceptores situados en la adventicia de estos vasos. El estimulo aferente viaja hasta el nucleo del haz solitario en el bulbo raquideo y otras areas en el puente donde se integran estos reflejos y la parte eferente genera cambios compensatorios en la frecuencia cardiaca y el tono del musculo liso vascular. Esta modificacion subita es la responsable de la variabilidad de la presion arterial latido a latido (corto plazo). Conclusion. Se realiza una revision sobre la historia, la fisiologia y los experimentos de los barorreflejos cardiovagal, cardiosimpatico y vasosimpatico y su influencia en la variabilidad de la presion arterial a corto plazo.

  1. Development of partial rock veneers by root throw in a subalpine setting

    USGS Publications Warehouse

    Osterkamp, W.R.; Toy, T.J.; Lenart, M.T.

    2006-01-01

    Rock veneers stabilize hillslope surfaces, occur especially in areas of immature soil, and form through a variety of process sets that includes root throw. Near Westcliffe, Colorado, USA, data were collected from a 20 ?? 500 m transect on the east slope of the Sangre de Cristo Mountains. Ages of pit/mound complexes with rock fragments exposed at the surface by root throw ranged from recent (freshly toppled tree) to unknown (complete tree decay). Calculations based on dimensions of the pit/mound complexes, estimated time of free topppling, sizes of exposed rock fragments, and percentage rock covers at pit/mound complexes, as well as within the transect area, indicate that recent rates of root throw have resulted in only partial rock veneering since late Pleistocene deglaciation. Weathering of rock fragments prevent development of an extensive rock veneer and causes a balance, achieved within an estimated 700 years, between the rates of rock-fragment exposure by root throw and clast disintegration by chemical reduction. The estimated rate of rock-fragment reduction accounts for part of the fluvial sediment yields observed for forested subalpine areas of western North America. Copyright ?? 2005 John Wiley & Sons, Ltd.

  2. Generalized surficial geology map of the Pueblo 1 degree by 2 degrees quadrangle, Colorado

    USGS Publications Warehouse

    Moore, D.W.; Straub, A.W.; Berry, M.E.; Baker, M.L.; Brandt, T.R.

    2002-01-01

    Fifty-three types of surficial geologic deposits and residual materials of Quaternary age are described in a pamphlet and located on a map of the greater Pueblo area, in part of the Front Range, in the Wet and Sangre de Cristo Mountains, and on the plains east of Colorado Springs and Pueblo. Deposits formed by landslides, wind, and glaciers, as well as colluvium, residuum, alluvium, and others are described in terms of predominant grain size, mineral or rock composition (e.g., gypsiferous, calcareous, granitic, andesitic), thickness, and other physical characteristics. Origins and ages of the deposits and geologic hazards related to them are noted. Many lines drawn between units on our map were placed by generalizing contacts on published maps. However, in 1997-1999 we mapped new boundaries as well. The map was projected to the UTM projection. This large map area extends from near Salida (on the west edge), eastward about 107 mi (172 km), and from Antero Reservoir and Woodland Park on the north edge to near Colorado City at the south edge (68 mi; 109 km).

  3. Controls on natural fracture variability in the Southern Raton Basin of Colorado and New Mexico.

    SciTech Connect

    Keefe, Russell G.; Cooper, Scott Patrick; Herrin, James M.; Larson, Rich; Lorenz, John Clay; Basinski, Paul M.; Olsson, William Arthur

    2004-07-01

    Natural fractures in Jurassic through Tertiary rock units of the Raton Basin locally contain conjugate shear fractures that are mechanically compatible with associated extension fractures, i.e., they have a bisector to the acute angle that is parallel to the strike of associated extension fractures, normal to the thrust front at the western margin of the basin. Both sets of fractures are therefore interpreted to have formed during Laramide-age thrusting from west to east that formed the Sangre de Cristo Mountains and subsequently the foreland Raton Basin, and that imposed strong east-west compressive stresses onto the strata filling the basin. This pattern is not universal, however. Anomalous NNE-SSW striking fractures locally dominate strata close to the thrust front, and fracture patterns are irregular in strata associated with anticlinal structures within the basin. Of special interest are strike-slip style conjugate shear fractures within Dakota Sandstone outcrops 60 miles to the east of the thrust front. Mohr-Coulomb failure diagrams are utilized to describe how these formed as well as how two distinctly different types of fractures can be formed in the same basin under the same regional tectonic setting and at the same time. The primary controls in this interpretation are simply the mechanical properties of the specific rock units and the depth of burial rather than significant changes in the applied stress.

  4. [Hepatitis B and delta: the prevalence of seroepidemiological markers in volunteer blood donors and their families].

    PubMed

    Alvarez-Muñoz, M T; Bustamante-Calvillo, M E; Guiscafré-Gallardo, J P; Muñoz, O

    1991-01-01

    41 volunteer blood donors and his relatives were studied in order to know about the prevalence of hepatitis B and D virus infections in selected groups. Frequency of HBsAg+ carriers was 0.34 per cent in the Centro Nacional de la Transfusión Sanguínea and 0.15 per cent in the Banco Central de Sangre, IMSS. Most of the HBsAg+ blood donors were 21 to 40 years old (87.8%); 21.9 per cent had IgM antibodies against HBc and just 2.4 per cent were HBeAg positive. Forty one (26.9%) of 152 relatives had one or more of the HBV markers, 3.9 per cent were HBsAg carriers and 1.3 per cent were HBeAg positive. In the infected relatives group 36.6 per cent were ancestory or brothers and just 14.6 per cent of wives were infected. None of the HBsAg+ blood donors or his relatives had antibodies against delta agent. These results support the fact that the frequency of asymptomatic carriers of HBsAg in the volunteer blood donors group is similar to he frequency in the general population and identifies the group of relatives as those with the highest risk to acquire HBV infection.

  5. Geographic distribution of three alkaloid chemotypes of Croton lechleri.

    PubMed

    Milanowski, Dennis J; Winter, Rudolph E K; Elvin-Lewis, Memory P F; Lewis, Walter H

    2002-06-01

    Three known alkaloids, isoboldine (2), norisoboldine (1), and magnoflorine (8), have been isolated for the first time from Croton lechleri, a source of the wound healing latex "sangre de grado". An HPLC system was developed, and a large number of latex and leaf samples of C. lechleri from 22 sites in northern Peru and Ecuador were analyzed to gain an understanding of the natural variation in alkaloid content for the species. Up to six alkaloids were found to occur in the leaves including, in addition to those listed above, thaliporphine (3), glaucine (4), and taspine (9), whereas the latex contained only 9. Taspine (9) is the component that has been previously found to be responsible for the wound healing activity of C. lechleri latex, and its mean concentration throughout the range examined was found to be 9% of the latex by dry weight. In addition, three chemotypes are defined based on the alkaloid content of the leaves, and the geographic distribution of these chemotypes is discussed along with a quantitative analysis of the alkaloid content as a function of chemotype.

  6. Definition of the Bacillus subtilis PurR operator using genetic and bioinformatic tools and expansion of the PurR regulon with glyA, guaC, pbuG, xpt-pbuX, yqhZ-folD, and pbuO.

    PubMed

    Saxild, H H; Brunstedt, K; Nielsen, K I; Jarmer, H; Nygaard, P

    2001-11-01

    The expression of the pur operon, which encodes enzymes of the purine biosynthetic pathway in Bacillus subtilis, is subject to control by the purR gene product (PurR) and phosphoribosylpyrophosphate. This control is also exerted on the purA and purR genes. A consensus sequence for the binding of PurR, named the PurBox, has been suggested (M. Kilstrup, S. G. Jessing, S. B. Wichmand-Jørgensen, M. Madsen, and D. Nilsson, J. Bacteriol. 180:3900-3906, 1998). To determine whether the expression of other genes might be regulated by PurR, we performed a search for PurBox sequences in the B. subtilis genome sequence and found several candidate PurBoxes. By the use of transcriptional lacZ fusions, five selected genes or operons (glyA, yumD, yebB, xpt-pbuX, and yqhZ-folD), all having a putative PurBox in their upstream regulatory regions, were found to be regulated by PurR. Using a machine-learning algorithm developed for sequence pattern finding, we found that all of the genes identified as being PurR regulated have two PurBoxes in their upstream control regions. The two boxes are divergently oriented, forming a palindromic sequence with the inverted repeats separated by 16 or 17 nucleotides. A computerized search revealed one additional PurR-regulated gene, ytiP. The significance of the tandem PurBox motifs was demonstrated in vivo by deletion analysis and site-directed mutagenesis of the two PurBox sequences located upstream of glyA. All six genes or operons encode enzymes or transporters playing a role in purine nucleotide metabolism. Functional analysis showed that yebB encodes the previously characterized hypoxanthine-guanine permease PbuG and that ytiP encodes another guanine-hypoxanthine permease and is now named pbuO. yumD encodes a GMP reductase and is now named guaC.

  7. Definition of a second Bacillus subtilis pur regulon comprising the pur and xpt-pbuX operons plus pbuG, nupG (yxjA), and pbuE (ydhL).

    PubMed

    Johansen, Lars Engholm; Nygaard, Per; Lassen, Catharina; Agersø, Yvonne; Saxild, Hans H

    2003-09-01

    In Bacillus subtilis expression of genes or operons encoding enzymes and other proteins involved in purine synthesis is affected by purine bases and nucleosides in the growth medium. The genes belonging to the PurR regulon (purR, purA, glyA, guaC, pbuO, pbuG, and the pur, yqhZ-folD, and xpt-pbuX operons) are controlled by the PurR repressor, which inhibits transcription initiation. Other genes are regulated by a less-well-described transcription termination mechanism that responds to the presence of hypoxanthine and guanine. The pur operon and the xpt-pbuX operon, which were studied here, are regulated by both mechanisms. We isolated two mutants resistant to 2-fluoroadenine in which the pur operon and the xpt-pbuX operon are expressed at increased levels in a PurR-independent manner. The mutations were caused by deletions that disrupted a potential transcription terminator structure located immediately upstream of the ydhL gene. The 5' part of the ydhL leader region contained a 63-nucleotide (nt) sequence very similar to the 5' ends of the leaders of the pur and xpt-pbuX operons. Transcripts of these regions may form a common tandem stem-loop secondary structure. Two additional genes with potential leader regions containing the 63-nt sequence are pbuG, encoding a hypoxanthine-guanine transporter, and yxjA, which was shown to encode a purine nucleoside transporter and is renamed nupG. Transcriptional lacZ fusions and mutations in the 63-nt sequence encoding the possible secondary structures provided evidence that expression of the pur and xpt-pbuX operons and expression of the ydhL, nupG, and pbuG genes are regulated by a common mechanism. The new pur regulon is designated the XptR regulon. Except for ydhL, the operons and genes were negatively regulated by hypoxanthine and guanine. ydhL was positively regulated. The derived amino acid sequence encoded by ydhL (now called pbuE) is similar to the amino acid sequences of metabolite efflux pumps. When overexpressed

  8. A transcriptional activator, homologous to the Bacillus subtilis PurR repressor, is required for expression of purine biosynthetic genes in Lactococcus lactis.

    PubMed

    Kilstrup, M; Martinussen, J

    1998-08-01

    A purR::pGh9:ISS1 mutant of Lactococcus lactis was obtained following transposon mutagenesis of strain MG1363 and selection for purine auxotrophs. After determination of the nucleotide sequence and deduction of the purR reading frame, the PurR product was found to be highly similar to the purR-encoded repressor from Bacillus subtilis. The wild-type purR gene complemented the purine auxotrophy of a purR::ISS1 mutant, and it was shown that the purR::ISS1 mutation lowered the level of transcription from the purine-regulated L. lactis purD promoter. In a parallel study on the regulation of purC and purD expression in L. lactis (M. Kilstrup, S. G. Jessing, S. B. Wichmand-Jorgensen, M. Madsen, and D. Nilsson, J. Bacteriol. 180:3900-3906, 1998), we identified regions (PurBox sequences: AWWWCCGAACWWT) upstream of the promoters with a central G residue at exactly position -76 relative to the transcriptional start site. The PurBox sequences were found to be required for high-level promoter activity and purine regulation. We identified a PurBox sequence overlapping the -35 region of the L. lactis purR promoter and found, by studies of a purR-lacLM fusion plasmid, that purR is autoregulated. Because of the high degree of similarity of the PurR proteins from B. subtilis and L. lactis, we looked for PurBox sequences in the promoter regions of the PurR-regulated genes in B. subtilis and identified a perfectly matching PurBox sequence in the purA promoter region and slightly degenerate PurBox-like sequences in the promoter regions for the pur operon and the purR gene. Interestingly, the PurBox in the pur operon of B. subtilis is located almost identically, with respect to the promoter, to the PurBox sequences located in front of purC and purD in L. lactis. We present a hypothesis to explain how an ancestral PurR protein in B. subtilis could have evolved from an activator of the pur operon into a repressor which regulates transcription initiation from the same pur promoter by using

  9. A distribuição de velocidades na linha de visada em galáxias barradas vistas de face

    NASA Astrophysics Data System (ADS)

    Gadotti, D. A.; de Souza, R. E.

    2003-08-01

    Com o objetivo de realizar um estudo cinemático da componente vertical de barras em galáxias, obtivemos espectros de fenda longa de alta razão S/N ao longo dos eixos maior e menor de 14 galáxias barradas vistas de face, nos telescópios de 1.52m do ESO em La Silla, Chile, e de 2.3m do Steward Observatory em Kitt Peak, Arizona. Estes dados nos permitiram determinar a distribuição de velocidades das estrelas ao longo do eixo vertical das barras e discos destes sistemas, tanto no centro como em pontos que distam cerca de 5 e 20 segundos de arco do núcleo, correspondendo a distâncias de cerca de 0.7 e 2.8 kpc, respectivamente. Desta forma, a variação radial da distribuição de velocidades também pôde ser avaliada. Este tipo de análise tem raros exemplos na literatura por ser caro em termos de tempo de telescópio. Entretanto, é de fácil justificativa, considerando que traz novas informações que podem ser utilizadas para aperfeiçoar modelos teóricos acerca da formação e evolução de galáxias. Um algoritmo por nós desenvolvido foi utilizado para obter as distribuições de velocidades como Gaussianas generalizadas (polinômios de Gauss-Hermite), o que traz um ingrediente a mais neste tipo de estudo que, tradicionalmente, se utiliza de Gaussianas puras, uma hipótese nem sempre razoável. Apresentaremos os resultados deste trabalho, que incluem um diagnóstico para a identificação de barras recém formadas, e testes para o modelo isotérmico de discos. Mostraremos que: (i) a escolha das estrelas padrão em velocidade, e dos parâmetros da Gaussiana, deve ser muito bem justificada já que tem influência significativa nos resultados; (ii) muitas galáxias apresentam uma depressão na dispersão de velocidades na região central, que pode estar associada a um disco interno; e (iii) a dispersão de velocidades é constante ao longo da barra, nos eixos maior e menor, mas cai substancialmente quando se passa da barra para o disco.

  10. U.S. Department of Energy FreedomCAR & Vehicle Technologies Program: Oil Bypass Filter Technology Evaluation Seventh Quarterly Report April - June 2004

    SciTech Connect

    Larry Zirker; James Francfort; Jordan Fielding

    2004-08-01

    This Oil Bypass Filter Technology Evaluation quarterly report (April–June 2004) details the ongoing fleet evaluation of an oil bypass filter technology by the Idaho National Engineering and Environmental Laboratory (INEEL) for the U.S. Department of Energy’s (DOE) FreedomCAR & Vehicle Technologies Program. Eight INEEL four-cycle diesel engine buses used to transport INEEL employees on various routes and six INEEL Chevrolet Tahoes with gasoline engines are equipped with oil bypass filter systems from the puraDYN Corporation. The bypass filters are reported to have engine oil filtering capability of <1 micron and a built-in additive package to facilitate extended oil-drain intervals. This quarter, the eight diesel engine buses traveled 85,632 miles. As of the end of June 2004, the eight buses have accumulated 498,814 miles since the beginning of the test and 473,192 miles without an oil change. This represents an avoidance of 39 oil changes, which equates to 1,374 quarts (343 gallons) of new oil not consumed and, furthermore, 1,374 quarts of waste oil not generated. One bus had its oil changed due to the degraded quality of the engine oil. Also this quarter, the six Tahoe test vehicles traveled 48,193 miles; to date, the six Tahoes have accumulated 109,708 total test miles. The oil for all six of the Tahoes was changed this quarter due to low Total Base Numbers (TBN). The oil used initially in the Tahoe testing was recycled oil; the recycled oil has been replaced with Castrol virgin oil, and the testing was restarted. However, the six Tahoe’s did travel a total of 98,266 miles on the initial engine oil. This represents an avoidance of 26 oil changes, which equates to 130 quarts (32.5 gallons) of new oil not consumed and, consequently, 130 quarts of waste oil not generated. Based on the number of oil changes avoided by the test buses and Tahoes to date, the potential engine oil savings if an oil bypass filter system were used was estimated for the INEEL, DOE

  11. Hippocampal phosphoproteomics of F344 rats exposed to 1-bromopropane

    SciTech Connect

    Huang, Zhenlie; Ichihara, Sahoko; Oikawa, Shinji; Chang, Jie; Zhang, Lingyi; Hu, Shijie; Huang, Hanlin; Ichihara, Gaku

    2015-01-15

    of GRP78, 14-3-3 θ, PSMC3, ST13, PURA, GNB2, APOE, PEA15 and ATP5H. • 1-BP-induced hippocampal damage involves inhibition of antiapoptosis process.

  12. Multi-Scale Influences of Climate, Spatial Pattern, and Positive Feedback on 20th Century Tree Establishment at Upper Treeline in the Rocky Mountains, USA

    NASA Astrophysics Data System (ADS)

    Elliott, G. P.

    2009-12-01

    The influences of 20th century climate, spatial pattern of tree establishment, and positive feedback were assessed to gain a more holistic understanding of how broad scale abiotic and local scale biotic components interact to govern upper treeline ecotonal dynamics along a latitudinal gradient (ca. 35°N-45°N) in the Rocky Mountains. Study sites (n = 22) were in the Bighorn, Medicine Bow, Front Range, and Sangre de Cristo mountain ranges. Dendroecological techniques were used for a broad scale analysis of climate at treeline. Five-year age-structure classes were compared with identical five-year bins of 20th century climate data using Spearman’s rank correlation and regime shift analysis. Local scale biotic interactions capable of ameliorating broad scale climate inputs through positive feedback were examined by using Ripley’s K to determine the spatial patterns of tree establishment above timberline. Significant correlations (p < 0.01) between tree establishment and climate were confined to the Front Range, where a positive correlation exists with summer (June-Aug) and cool season (Nov-Apr) temperature range (Tmax-Tmin). Additionally, trees in the Front Range are almost exclusively situated in a random spatial pattern above timberline (4/5 sites). Random spatial patterns imply that positive feedback is of minimal importance and that trees are more closely aligned with broad scale changes in abiotic conditions. This tight coupling between climate and treeline vegetation in the Front Range helps explain synchronous ecological (tree establishment) and climate regime shifts (temperature) during the early 1950s. Similar to the Front Range, a majority of trees at upper treeline in the Bighorn Mountains are in a random spatial pattern, but their existence appears to be dependent on shelter availability in the lee of boulders. This contingency helps explain the lag time between a regime shift to more favorable temperatures and subsequent peaks in tree establishment

  13. EFFECT OF CHIA SEED (SALVIA HISPANICA L.) CONSUMPTION ON CARDIOVASCULAR RISK FACTORS IN HUMANS: A SYSTEMATIC REVIEW.

    PubMed

    de Souza Ferreira, Cynthia; dd Sousa Fomes, Lucilia de Fátima; da Silva, Gilze Espirito Santo; Rosa, Glorimar

    2015-11-01

    ólica (PAS) y los marcadores de inflamación; sin embargo, no hubo cambios en la masa corporal, el perfil de lípidos o el azúcar en sangre. En cuatro de los estudios revisados no había un pico significativo en ALA y ácido eicosapentaenoico (EPA), ni ningún cambio significativo en otros parámetros. En los ensayos agudos, el nivel postprandial de azúcar en sangre fue significativamente menor. Solo un estudio mostró un descenso significativo de los triglicéridos (TG), la masa corporal y los marcadores inflamatorios; sin embargo, la semilla de chía en ese caso se mezcló con otros alimentos. La mayoría de los estudios mostraron riesgos claros o bajo sesgo. Dos estudios mostraron un alto riesgo de sesgo, porque no todos los resultados primarios preespecificados fueron reportados en los hallazgos. Conclusión: la mayoría de los estudios no demostraron resultados estadísticamente significativos en relación con los factores de riesgo cardiovascular (ECV). La evidencia sobre la relación entre el consumo de semillas de chía y los factores de riesgo cardiovascular son insuficientes, y los estudios incluidos en esta revisión presentan numerosas limitaciones. Por lo tanto, se necesita más investigación.

  14. [EFFICIENCY OF HAEMOGLOBIN REGENERATION IN THE NUTRITIONAL FERROPENIC ANAEMIA RECOVERY WITH GOAT MILK-BASED DIETS].

    PubMed

    Serrano Reina, José Antonio; Nestares Pleguezuelo, Teresa; Muñoz Alférez, Ma José; Díaz Castro, Javier; López Aliaga, Ma Inmaculada

    2015-10-01

    Objetivo: a pesar de la alta incidencia de anemia ferropénica y de los efectos beneficiosos derivados del consumo de leche de cabra, poco se conoce, en realidad, acerca de la recuperación de la anemia mediante una dieta equilibrada acompañada de la ingesta de leche de cabra. El objetivo del presente estudio es determinar, en ratas con anemia ferropénica nutricional, los efectos de dietas elaboradas a base de leche de cabra, en comparación con la de vaca, suministradas durante 30 días, sobre la recuperación de la anemia y la eficacia de regeneración de la hemoglobina. Material y métodos: se han utilizado 40 ratas macho Wistar albina recién destetadas divididas al azar en dos grupos experimentales y alimentadas ad libitum durante 40 días con dieta AIN-93G con contenido normal de hierro (grupo control, 45 mg/kg dieta), o bajo (grupo anémico, 5 mg/kg dieta). Se toman muestras de sangre de la vena caudal para el control hematológico de la anemia. Posteriormente, cada uno de los dos grupos experimentales (control y ferrodeficiente) fueron alimentados durante 30 días con dietas elaboradas a base de leche de cabra o vaca. Al finalizar el período experimental y previa anestesia, las ratas se desangran por canulación de la aorta abdominal, y la sangre obtenida se recoge en un tubo con EDTA como anticoagulante para la posterior determinación de los parámetros hematológicos y la eficacia de regeneración de la hemoglobina. Resultados y discusión: tras el consumo de una dieta con bajo contenido en hierro durante 40 días, las ratas eran anémicas, con una concentración de hemoglobina, hematocrito, hierro sérico, volumen corpuscular medio (VCM), ferritina sérica y saturación de la transferrina bajos (p < 0,001), mientras que los niveles de plaquetas y la capacidad total de unión al hierro (TIBC) estaban elevados (p < 0,001), hallazgos consistentes con la anemia inducida experimentalmente en ratas. La eficacia de regeneración de la hemoglobina era mayor

  15. ANEMIA IN PREGNANCY: IMPACT ON WEIGHT AND IN THE DEVELOPMENT OF ANEMIA IN NEWBORN.

    PubMed

    de Sá, Solange Augusta; Willner, Erica; Duraes Pereira, Tatiane Aguiar; de Souza, Vanessa Rosse; Teles Boaventura, Gilson; Blondet de Azeredo, Vilma

    2015-11-01

    Introducción: la anemia gestacional todavía se considera un problema de salud pública en Brasil y se asocia con un mayor riesgo de morbilidad materno-fetal y el estado nutricional de los niños en el período posparto. Objetivo: evaluar la frecuencia de la anemia gestacional materna en recién nacidos y su relación con el estado nutricional del niño al nacer. Métodos: se obtuvieron datos antropométricos de las mujeres embarazadas y los recién nacidos. Se recogieron muestras de sangre de mujeres embarazadas y de cordón umbilical de los recién nacidos para su posterior análisis de hemoglobina, hematocrito, ADE, hierro, ferritina e índice de saturación de transferrina en dispositivos automatizados. Los resultados se presentan como media y la desviación estándar. Fue utilizado el software GraphPadinStat®, versión 3.0 y se aceptó un nivel de significación del 5%. Resultados: la frecuencia de anemia materna era de 53,7% y 32,6% en los recién nacidos. La mitad de los recién nacidos eran niños anémicos de madres anémicas. De las mujeres embarazadas con anemia, el 79,3% tenían anemia leve y el 20,7% moderada. La concentración media de hemoglobina y hematocrito fue menor en las mujeres embarazadas con anemia (9,7 ± 0,9 g/ dl y 29,8 ± 3,2%) en comparación con las no anémicas (11,9 ± 0,7 g/dl y 36,5 ± 2,7%), como se esperaba. El nivel de hierro de la madre se correlacionó positivamente con ferritina (r = 0,389; p = 0,01) a partir de la sangre del cordón umbilical. El peso, la longitud y la circunferencia de la cabeza de los niños nacidos de madres anémicas fueron: 3.375,9 ± 506,9 g, 51,2 ± 1,7 cm y 34,5 ± 1,5 cm, respectivamente, mientras que entre los recién nacidos de madres no anémicas fueron: 3.300,2 ± 458,4 g, 50,3 ± 2,0 cm y 34,2 ± 2,0 cm, respectivamente. No se encontraron correlaciones significativas entre la hemoglobina, el hierro y la ferritina de la madre, y el peso, la longitud y la circunferencia de la cabeza de los reci

  16. Geothermal potential for commercial and industrial direct heat applications in Salida, Colorado. Final report

    SciTech Connect

    Coe, B.A.; Dick, J.D.; Galloway, M.J.; Gross, J.T.; Meyer, R.T.; Raskin, R.; Zocholl, J.R.

    1982-10-01

    The Salida Geothermal Prospect (Poncha Hot Springs) was evaluated for industrial and commercial direct heat applications at Salida, Colorado, which is located approximately five miles east of Poncha Hot Springs. Chaffee Geothermal, Ltd., holds the geothermal leases on the prospect and the right-of-way for the main pipeline to Salida. The Poncha Hot Springs are located at the intersection of two major structural trends, immediately between the Upper Arkansas graben and the Sangre de Cristo uplift. Prominent east-west faulting occurs at the actual location of the hot springs. Preliminary exploration indicates that 1600 gpm of geothermal fluid as hot as 250/sup 0/F is likely to be found at around 1500 feet in depth. The prospective existing endusers were estimated to require 5.02 x 10/sup 10/ Btu per year, but the total annual amount of geothermal energy available for existing and future endusers is 28.14 x 10/sup 10/ Btu. The engineering design for the study assumed that the 1600 gpm would be fully utilized. Some users would be cascaded and the spent fluid would be cooled and discharged to nearby rivers. The economic analysis assumes that two separate businesses, the energy producer and the energy distributor, are participants in the geothermal project. The producer would be an existing limited partnership, with Chaffee Geothermal, Ltd. as one of the partners; the distributor would be a new Colorado corporation without additional income sources. Economic evaluations were performed in full for four cases: the Base Case and three alternate scenarios. Alternate 1 assumes a three-year delay in realizing full production relative to the Base Case; Alternate 2 assumes that the geothermal reservoir is of a higher quality than is assumed for the Base Case; and Alternate 3 assumes a lower quality reservoir. 11 refs., 34 figs., 40 tabs.

  17. [Diploid/triploid mosaicism: a variable but characteristic phenotype].

    PubMed

    Natera-De Benito, Daniel; Poo, Pilar; Gean, Esther; Vicente-Villa, Asunción; García-Cazorla, Angels; Fons-Estupiña, M Carmen

    2014-08-16

    Introduccion. El mosaicismo diploide/triploide es una alteracion cromosomica poco frecuente. La produce un fallo en la division poscigotica durante el desarrollo embrionario. Da lugar a la coexistencia de dos lineas celulares con diferente constitucion cromosomica (46,XX y 69,XXX) en un mismo individuo. Su fenotipo clinico es caracteristico. Las alteraciones pigmentarias con un patron de distribucion que sigue las lineas de Blaschko son el principal signo guia, asi como las alteraciones de otros tejidos derivados del ectodermo. Casos clinicos. Describimos las caracteristicas clinicas de tres pacientes afectos de mosaicismo diploide/triploide y realizamos una comparacion de su fenotipo clinico con el de los casos publicados previamente en la bibliografia. Las alteraciones observadas con mayor frecuencia fueron alteraciones cutaneas, discapacidad intelectual, obesidad troncular, talla baja, hemihipertrofia, y manos pequeñas y estrechas con clino y camptodactilia. Las caracteristicas fenotipicas de nuestros pacientes fueron similares a las de los casos comunicados previamente. Aunque no existe un fenotipo unico y especifico asociado al mosaicismo diploide/triploide, existen malformaciones caracteristicas que conforman un sindrome malformativo bien definido. El cariotipo realizado en linfocitos de sangre periferica en las tres pacientes fue normal, y se logro el diagnostico mediante cariotipo en fibroblastos cultivados tras biopsia de piel hipopigmentada. Conclusiones. La presencia de discapacidad intelectual asociada a obesidad troncular, talla baja, hemihipertrofia o clino y camptodactilia, ademas de las alteraciones cutaneas, debe hacer pensar en la posible existencia de un mosaicismo diploide/triploide. En la mayoria de los casos, es necesario el estudio del cariotipo en los fibroblastos para llegar al diagnostico.

  18. Provenance record of Paleogene exhumation and Laramide basin evolution along the southern Rocky Mountain front

    NASA Astrophysics Data System (ADS)

    Bush, M. A.; Horton, B. K.; Murphy, M. A.; Stockli, D. F.

    2015-12-01

    The Sangre de Cristo and Nacimiento uplifts of the southern Rocky Mountains formed key parts of a major Paleogene topographic boundary separating the Cordilleran orogenic system from the North American plate interior. This barrier largely isolated interior Laramide basins from a broad Laramide foreland with fluvial systems draining to the Gulf of Mexico, and thereby played a critical role in the evolution of continental-scale paleodrainage patterns. New detrital zircon U-Pb geochronology and heavy mineral provenance analyses of Cretaceous-Paleogene siliciclastic strata in the Raton, Galisteo-El Rito, and San Juan basins record the partitioning of the broad Cordilleran (Sevier) foreland basin by Laramide basement uplifts. These trends are recognized both in provenance signals and depositional styles corresponding to cratonward (eastward) propagation of the Laramide deformation front and resultant advance of flexural depocenters in the North American interior. Along the eastern flank of the deformation front, the Raton basin shows a mix of Cordilleran, Appalachian, and Grenville age zircons restricted to the Cretaceous Dakota and Vermejo formations, marine units of the Western Interior Seaway. Upsection, the Cordilleran age peaks are absent from Paleocene-Eocene units, consistent with significant Laramide drainage reorganization and isolation from Cordilleran sources to the west. In the Galisteo-El Rito basin system, a shift to dominantly Mazatzal-Yavapai basement ages is recognized in the Paleocene El Rito and Oligocene Ritito formations. The heavy mineral results show a corresponding shift to less mature, dominantly metamorphic source compositions. These new datasets bear upon Cretaceous-Cenozoic reconstructions of North American paleodrainage and have implications for potential linkages between major fluvial systems of the southern Rocky Mountains and Paleogene deepwater reservoir units in the Gulf of Mexico basin.

  19. Use of fission track dates as constraints on the tectonic evolution of the Rio Grande rift. [Abstract only

    SciTech Connect

    Kelley, S.A.; Duncan, I.J.; Blackwell, D.D.

    1983-03-01

    Apatite fission track dates have been determined for Precambrian and Tertiary granitic rocks collected from four ranges on the eastern margin of the Rio Grande rift. The ages at lower elevation in these areas are, in general, younger than those at higher elevation because of cooling as uplift occurs. Thus apparent uplift rates can be calculated from this relation between elevation and age, assuming that the geothermal gradient remained constant during uplift and erosion. Age dates on samples from the Wheeler Peak area north of Taos and the Sandia Mountains near Albuquerque indicate that the rocks at the higher elevations in these areas cooled to approx. 105/sup 0/C 30 to 35 Ma ago. The dates suggest that Precambrian rocks in the Wheeler Peak area were heated by a thermal event related to the Questa Caldera. Dates for the Tertiary intrusions in this area imply that uplift at an apparent rate of 0.1 mm/a has occurred since the intrusions cooled (20 Ma). The uplift of Sandia block, which does not seem to be directly associated with igneous activity, occurred at an average rate of .055 mm/a. Dates from the Organ batholith in southern New Mexico do not show a clear relation with elevation. The fission track dates (16 to 36 Ma) are consistent with shallow emplacement and subsequent rapid uplift of the batholith followed by formation of small geothermal systems sometime later in the Tertiary. In contrast to the other three areas where Tertiary tectonic activity affects the ages, dates from the Sangre de Cristo Mountains east of Sante Fe are related to Laramide uplift about 65 to 70 Ma ago. The apparent uplift rate is 0.072 mm/a. The data on the rate and timing of uplift imply that the heat sources that have caused the Tertiary tectonic and igneous features observed in the rift are not continuous along the rift's length, but are localized phenomena.

  20. New Mexico structural zone - An analogue of the Colorado mineral belt

    USGS Publications Warehouse

    Sims, P.K.; Stein, H.J.; Finn, C.A.

    2002-01-01

    Updated aeromagnetic maps of New Mexico together with current knowledge of the basement geology in the northern part of the state (Sangre de Cristo and Sandia-Manzano Mountains)-where basement rocks were exposed in Precambrian-cored uplifts-indicate that the northeast-trending Proterozoic shear zones that controlled localization of ore deposits in the Colorado mineral belt extend laterally into New Mexico. The shear zones in New Mexico coincide spatially with known epigenetic precious- and base-metal ore deposits; thus, the mineralized belts in the two states share a common inherited basement tectonic setting. Reactivation of the basement structures in Late Cretaceous-Eocene and Mid-Tertiary times provided zones of weakness for emplacement of magmas and conduits for ore-forming solutions. Ore deposits in the Colorado mineral belt are of both Late Cretaceous-Eocene and Mid-Tertiary age; those in New Mexico are predominantly Mid-Tertiary in age, but include Late Cretaceous porphyry-copper deposits in southwestern New Mexico. The mineralized belt in New Mexico, named the New Mexico structural zone, is 250-km wide. The northwest boundary is the Jemez subzone (or the approximately equivalent Globe belt), and the southeastern boundary was approximately marked by the Santa Rita belt. Three groups (subzones) of mineral deposits characterize the structural zone: (1) Mid-Tertiary porphyry molybdenite and alkaline-precious-metal deposits, in the northeast segment of the Jemez zone; (2) Mid-Tertiary epithermal precious-metal deposits in the Tijeras (intermediate) zone; and (3) Late Cretaceous porphyry-copper deposits in the Santa Rita zone. The structural zone was inferred to extend from New Mexico into adjacent Arizona. The structural zone provides favorable sites for exploration, particularly those parts of the Jemez subzone covered by Neogene volcanic and sedimentary rocks. ?? 2002 Published by Elsevier Science B.V.

  1. Streamflow, Infiltration, and Recharge in Arroyo Hondo, New Mexico

    USGS Publications Warehouse

    Moore, Stephanie J.

    2007-01-01

    Infiltration events in channels that flow only sporadically produce focused recharge to the Tesuque aquifer in the Espa?ola Basin. The current study examined the quantity and timing of streamflow and associated infiltration in Arroyo Hondo, an unregulated mountain-front stream that enters the basin from the western slope of the Sangre de Cristo Mountains. Traditional methods of stream gaging were combined with environmental-tracer based methods to provide the estimates. The study was conducted during a three-year period, October 1999?October 2002. The period was characterized by generally low precipitation and runoff. Summer monsoonal rains produced four brief periods of streamflow in water year 2000, only three of which extended beyond the mountain front, and negligible runoff in subsequent years. The largest peak flow during summer monsoon events was 0.59 cubic meters per second. Snowmelt was the main contributor to annual streamflow. Snowmelt produced more cumulative flow downstream from the mountain front during the study period than summer monsoonal rains. The presence or absence of streamflow downstream of the mountain front was determined by interpretation of streambed thermographs. Infiltration rates were estimated by numerical modeling of transient vertical streambed temperature profiles. Snowmelt extended throughout the instrumented reach during the spring of 2001. Flow was recorded at a station two kilometers downstream from the mountain front for six consecutive days in March. Inverse modeling of this event indicated an average infiltration rate of 1.4 meters per day at this location. For the entire study reach, the estimated total annual volume of infiltration ranged from 17,100 to 246,000 m3 during water years 2000 and 2001. During water year 2002, due to severe drought, streamflow and streambed infiltration in the study reach were both zero.

  2. [Tropical spastic paraparesis in a non tropical region].

    PubMed

    Pias-Peleteiro, L; Pias-Peleteiro, J M; Arias, M

    2015-10-16

    Introduccion. El virus linfotropo humano de celulas T tipo 1 (HTLV-1) es el agente causal de la paraparesia espastica tropical. Su prevalencia, elevada en determinadas areas tropicales, es baja en Europa y Norteamerica. Casos clinicos. Se describen dos casos de paraparesia espastica tropical en varones naturales y residentes en Galicia. Se realizaron estudios analiticos en la sangre y el liquido cefalorraquideo (LCR), examenes neurofisiologicos y resonancia magnetica craneal y medular. En ambos pacientes, la presentacion clinica fue la de una mielopatia cronica, con cuadro torpido y progresivo que evoluciono a paraparesia espastica. Un paciente desarrollo uveitis antes de la clinica neurologica. En los dos casos, el estudio del LCR demostro leve pleocitosis linfoide, ligera hiperproteinorraquia, bandas oligoclonales negativas y anticuerpos anti-HTLV-1 positivos. La reaccion en cadena de la polimerasa para HTLV-1 resulto positiva en ambos casos. La resonancia magnetica raquidea resulto normal en un paciente y mostro en el otro hiperseñal medular dorsal, que desaparecio tras el tratamiento. No se demostraron datos de polineuropatia periferica. Recibieron corticoides e interferon alfa, con leve mejoria y estabilizacion del cuadro clinico. La anamnesis dirigida revelo antecedentes de contactos sexuales de riesgo en regiones endemicas de HTLV-1. Conclusiones. La uveitis asociada a HTLV-1 podria ser predictora de paraparesia espastica tropical. Esta es probablemente una entidad infradiagnosticada (alto porcentaje de portadores asintomaticos, clinica insidiosa y bajo indice de sospecha en areas no endemicas). Debe considerarse su diagnostico en zonas no tropicales que reciben inmigrantes de areas endemicas y tambien en regiones con una tradicional emigracion a regiones tropicales.

  3. On the origin and age of the Great Sand Dunes, Colorado

    USGS Publications Warehouse

    Madole, R.F.; Romig, J.H.; Aleinikoff, J.N.; VanSistine, D.P.; Yacob, E.Y.

    2008-01-01

    Over the past 100??yr, several hypotheses have been proposed for the origin and age of the Great Sand Dunes. These hypotheses differ widely in the descriptions of dune morphometry, the immediate source of eolian sand, and when sand transport occurred. The primary purpose of this paper is to evaluate these hypotheses and, where warranted, to present new ideas about the origin and age of the Great Sand Dunes. To evaluate the previous hypotheses, we had to develop more detailed information about the surficial geology of the northern San Luis Valley. Thus, we mapped the surficial geology of an area extending several tens of kilometers north, south, and west of the Great Sand Dunes and examined subsurface stratigraphy in more than 200 wells and borings. In addition, we used relative-dating criteria and several radiocarbon and OSL ages to establish the chronology of surficial deposits, and we determined the U-Pb ages of detrital zircons to obtain information about the sources of the sand in the Great Sand Dunes. The first principal finding of this study is that the lower part of the closed basin north of the Rio Grande, referred to here as the sump, is the immediate source of the sand in the Great Sand Dunes, rather than the late Pleistocene flood plain of the Rio Grande (the most widely accepted hypothesis). A second principal finding is that the Great Sand Dunes are older than late Pleistocene. They postdate the draining of Lake Alamosa, which began ??? 440??ka, and predate the time when streams draining the west flank of the Sangre de Cristo Mountains were deflected by incipient dunes that formed near the mountain front. Geomorphic and stratigraphic evidence indicate that this deflection occurred prior to the end of the next to last glaciation (Bull Lake), i.e., prior to ??? 130??ka.

  4. Temporal variability of mass transport across Canary Islands Channels

    NASA Astrophysics Data System (ADS)

    Marrero-Díaz, Ángeles; Rodríguez-Santana, Ángel; José Machín, Francisco; García-Weil, Luis; Sangrà, Pablo; Vélez-Belchí, Pedro; Fraile-Nuez, Eugenio

    2014-05-01

    The equatorward flowing Canary Current (CC) is the main feature of the circulation in the Canary Islands region. The CC flow perturbation by the Canary Islands originate the Canary Eddy Corridor which is the major pathway for long lived eddies in the subtropical North Atlantic (Sangrà et al., 2009, DSR). Therefore the variability of the CC passing through the Canary Archipelago will have both local and regional importance. Past studies on the CC variability trough the Canary Islands point out a clearly seasonal variability (Fraile-Nuez et al, 2010 (JGR); Hernández-Guerra et al, 2002 (DSR)). However those studies where focused on the eastern islands channels missing the variability through the western island channels which are the main source of long lived eddies. In order to fill this gap from November 2012 until September 2013 we conducted trimonthly surveys crossing the whole islands channels using opportunity ships (Naviera Armas Ferries). XBT and XCTD where launched along the cross channels transects. Additionally a closed box circling the Archipelago was performed on October 2013 as part of the cruise RAPROCAN-2013 (IEO) using also XBT and XCTD. Dynamical variables where derived inferring salinity from S(T,p) analytical relationships for the region updated with new XCTD data. High resolution, vertical sections of temperature, potential density, geostrophic velocity and transport where obtained. Our preliminary results suggest that the CC suffer a noticeable acceleration in those islands channels where eddy shedding is more frequent. They also indicate a clearly seasonal variability of the flows passing the islands channels. With this regard we observed significant differences on the obtained seasonal variability with respect the cited past studies on the eastern islands channel (Lanzarote / Fuerteventura - Africa coast). This work was co-funded by Canary Government (TRAMIC project: PROID20100092) and the European Union (FEDER).

  5. [Not Available].

    PubMed

    Domínguez, Raúl; Garnacho-Castaño, Manuel Vicente; Maté-Muñoz, José Luis

    2016-01-01

    La fuerza influye directamente en el estado de salud y en la capacidad de fitness, motivo por el que el entrenamiento contra resistencias o resistance training (RT) se incluye dentro de aquellos programas de ejercicio encaminados a mejorar la salud y calidad de vida. Debido a que muchasenfermedades cursan con alteración de la masa y funcionalidad muscular y a que el RT es la principal modalidad de ejercicio encaminada a mejorar la función muscular, el objetivo de la presente revisión bibliográfica ha sido exponer las evidencias actuales sobre las adaptaciones delRT, así como su posible aplicación en patologías como la obesidad, diabetes, dislipemia, hipertensión, cáncer, Parkinson, esclerosis múltiple o fibromialgia. El RT en estas enfermedades puede aumentar los niveles de masa muscular, disminuyendo los niveles de masa grasa, los nivelesde ácidos grasos en sangre y la glucemia, incrementando la sensibilidad a la insulina, y disminuyendo los niveles de citokinas inflamatorias. El RT, además, mejora el gasto cardiaco y la funcionalidad endotelial, regulando la tensión arterial e incrementando el consumo de oxígeno. Las ganancias de fuerza muscular mejoran la funcionalidad y la calidad de vida, especialmente en población con una afectación neuromuscular grave, como pudieran ser los enfermos de esclerosis múltiple, fibromialgia o Parkinson. Por ello, el RT debe ser incorporado como parte del tratamiento en las personas que presentan determinado tipo de patologías. PMID:27513511

  6. Late Miocene-Pleistocene evolution of a Rio Grande rift subbasin, Sunshine Valley-Costilla Plain, San Luis Basin, New Mexico and Colorado

    USGS Publications Warehouse

    Ruleman, C.A.; Thompson, R.A.; Shroba, R.R.; Anderson, M.; Drenth, B.J.; Rotzien, J.; Lyon, J.

    2013-01-01

    The Sunshine Valley–Costilla Plain, a structural subbasin of the greater San Luis Basin of the northern Rio Grande rift, is bounded to the north and south by the San Luis Hills and the Red River fault zone, respectively. Surficial mapping, neotectonic investigations, geochronology, and geophysics demonstrate that the structural, volcanic, and geomorphic evolution of the basin involves the intermingling of climatic cycles and spatially and temporally varying tectonic activity of the Rio Grande rift system. Tectonic activity has transferred between range-bounding and intrabasin faults creating relict landforms of higher tectonic-activity rates along the mountain-piedmont junction. Pliocene–Pleistocene average long-term slip rates along the southern Sangre de Cristo fault zone range between 0.1 and 0.2 mm/year with late Pleistocene slip rates approximately half (0.06 mm/year) of the longer Quaternary slip rate. During the late Pleistocene, climatic influences have been dominant over tectonic influences on mountain-front geomorphic processes. Geomorphic evidence suggests that this once-closed subbasin was integrated into the Rio Grande prior to the integration of the once-closed northern San Luis Basin, north of the San Luis Hills, Colorado; however, deep canyon incision, north of the Red River and south of the San Luis Hills, initiated relatively coeval to the integration of the northern San Luis Basin. Long-term projections of slip rates applied to a 1.6 km basin depth defined from geophysical modeling suggests that rifting initiated within this subbasin between 20 and 10 Ma. Geologic mapping and geophysical interpretations reveal a complex network of northwest-, northeast-, and north-south–trending faults. Northwest- and northeast-trending faults show dual polarity and are crosscut by north-south– trending faults. This structural model possibly provides an analog for how some intracontinental rift structures evolve through time.

  7. [Perinatal infection by rubella virus in breast-fed babies with congenital heart disease].

    PubMed

    Solórzano-Santos, Fortino; Bárcenas-López, Selene Jeannette; Huerta-García, Gloria C; Miranda-Novales, María Guadalupe; Alvarez-Y Muñoz, María Teresa; Vázquez-Rosales, José Guillermo

    2013-01-01

    Introducción: las encuestas seroepidemiológicas sugieren que 20 % de las mujeres en edad fértil es susceptible a la rubéola. El objetivo de esta investigación fue determinar la frecuencia de infección perinatal por el virus de la rubéola en lactantes con cardiopatía congénita. Métodos: estudio prospectivo y transversal de niños menores de un año de edad con diagnóstico de cardiopatía congénita. Se tomaron 3 mL de sangre al binomio madre-hijo y se realizó ELISA de micropartículas para anticuerpos IgG e IgM contra la rubéola. Resultados: se estudiaron 80 pacientes con edad de tres meses; 56 % era del sexo femenino. Las cardiopatías congénitas más frecuentes fueron las comunicaciones interventricular (28.5 %) y la interauricular (17.5 %). La mediana de la edad materna fue de 28 años; 1.25 % de las madres tuvo antecedente de enfermedad febril y exantema durante el embarazo. Se detectaron siete casos (8.75 %) de infección perinatal por el virus de la rubéola, tres cumplieron el criterio de síndrome de rubéola congénita y cuatro de cardiopatía. Conclusiones: se sugiere buscar rubéola congénita en los recién nacidos y lactantes con cardiopatías, como una estrategia para detectar los casos no obvios.

  8. EFFECT OF ANTIOXIDANT POTENTIAL ON SEVERITY OF CIRRHOSIS IN HUMANS.

    PubMed

    Colpo, Elisangela; Gomes Farias, Julia; Gomes Farias, Iria Luiza; Brenner Reetz, Luiz Gustavo; Oliveira, Liliane; Michelon de Carli, Diego; Irineu Müller, Edson; Marlon de Moraes Flores, Érico; Roth Dalcin, Saulo; Teixeira da Rocha, João Batista

    2015-11-01

    Introducción/Objetivos: examinar la relación entre los potenciales antioxidantes y los parámetros de gravedad de la cirrosis en los seres humanos. Métodos: quince pacientes con cirrosis hepática (nueve sujetos - grupo Child B, y seis sujetos - grupo Child C) y nueve sujetos control fueron incluidos en el estudio. Los principales criterios que se tuvieron en cuenta para caracterizar el diagnóstico de la cirrosis y sus complicaciones fueron la AST: relación de ALT, AST índice de la relación de plaquetas, clasificación Bonacini, clasificación MELD y clasificación de Child. Estos parámetros fueron determinados con base en los resultados de laboratorio y los registros clínicos del paciente. Se midieron los niveles de Zn, ácido ascórbico (AA) y los parámetros de estrés oxidativo en muestras de sangre de pacientes cirróticos. Resultados: el análisis de los niveles plasmáticos de Se y AA mostraron bajas concentraciones en los pacientes cirróticos en comparación con los sujetos control (P < 0,05); sin embargo, hubo una correlación positiva entre el plasma de Se y los parámetros de gravedad de la cirrosis en pacientes del grupo Child B y C. En la actividad de las enzimas antioxidantes catalasa solamente fue menor en los pacientes del grupo Child C, en comparación con el grupo control. Conclusión: se encontraron niveles bajos en plasma de Se y AA en pacientes cirróticos. Sin embargo, no está claro por qué los niveles de selenio tienden a aumentar con la gravedad de la cirrosis hepática.

  9. [Clinico-radiological profile of acute disseminated encephalomyelitis in the childhood population. A retrospective analysis of a series of 20 patients in a tertiary hospital].

    PubMed

    Tomás-Vila, Miguel; Menor, Francisco; Otero-Reigada, M Carmen; Pérez-Tamarit, Amparo; Téllez de Meneses, Montserrat; Pitarch-Castellanos, Inmaculada

    2014-01-01

    Introduccion. La encefalomielitis aguda diseminada (EAD) es un trastorno inflamatorio del sistema nervioso central mediado inmunologicamente y de patogenia desconocida. Puede presentarse en cualquier edad, pero es mucho mas frecuente en niños. La EAD no tiene marcador biologico especifico y el diagnostico se basa en hallazgos clinicos y neurorradiologicos. Objetivo. Mejorar el conocimiento del perfil clinicorradiologico de esta enfermedad. Pacientes y metodos. Estudio retrospectivo con inclusion de pacientes menores de 14 años ingresados en un hospital terciario en los ultimos 15 años con el diagnostico de EAD. Se revisaron antecedentes, signos clinicos de presentacion, datos analiticos en sangre/liquido cefalorraquideo y la semiologia radiologica. En 16 casos se realizo un seguimiento medio de 25 meses. Resultados. Se revisaron 20 pacientes, un 70% niños, con una edad media de 4,4 años. El 40% tuvo un episodio febril previo. El 85% presento fiebre o vomitos, y el 70%, afectacion del estado de consciencia. Predominaron los deficits motores (45%), las convulsiones (35%) y la afectacion de pares craneales (30%). Tres niños presentaron una evolucion recidivante, y otros tres, secuelas motoras. Los estudios de resonancia magnetica mostraron lesiones hiperintensas en secuencias T2, con patron de realce escaso o nulo, que predominaron en los talamos (70%), la medula (67%) y la sustancia blanca subcortical (50%). En dos pacientes se diagnostico EAD hemorragica. Conclusiones. La EAD representa una entidad con importante afectacion general y repercusion neurologica, que muestra un potencial secuelar considerable. Los datos clinicoanaliticos y la resonancia magnetica cerebral y medular son relevantes para el diagnostico inicial y seguimiento de pacientes con EAD.

  10. Numerical Modeling of Rocky Mountain Paleoglaciers - Insights into the Climate of the Last Glacial Maximum and the Subsequent Deglaciation

    NASA Astrophysics Data System (ADS)

    Leonard, E. M.; Laabs, B. J. C.; Plummer, M. A.

    2014-12-01

    Numerical modeling of paleoglaciers can yield information on the climatic conditions necessary to sustain those glaciers. In this study we apply a coupled 2-d mass/energy balance and flow model (Plummer and Phillips, 2003) to reconstruct local last glacial maximum (LLGM) glaciers and paleoclimate in ten study areas along the crest of the U.S. Rocky Mountains between 33°N and 49°N. In some of the areas, where timing of post-LLGM ice recession is constrained by surface exposure ages on either polished bedrock upvalley from the LLGM moraines or post-LLGM recessional moraines, we use the model to assess magnitudes and rates of climate change during deglaciation. The modeling reveals a complex pattern of LLGM climate. The magnitude of LLGM-to-modern climate change (temperature and/or precipitation change) was greater in both the northern (Montana) Rocky Mountains and southern (New Mexico) Rocky Mountains than in the middle (Wyoming and Colorado) Rocky Mountains. We use temperature depression estimates from global and regional climate models to infer LLGM precipitation from our glacier model results. Our results suggest a reduction of precipitation coupled with strongly depressed temperatures in the north, contrasted with strongly enhanced precipitation and much more modest temperature depression in the south. The middle Rocky Mountains of Colorado and Wyoming appear to have experienced a reduction in precipitation at the LLGM without the strong temperature depression of the northern Rocky Mountains. Preliminary work on modeling of deglaciation in the Sangre de Cristo Range in southern Colorado suggests that approximately half of the LLGM-to-modern climate change took place during the initial ~2400 years of deglaciation. If increasing temperature and changing solar insolation were the sole drivers of this initial deglaciation, then temperature would need to have risen by slightly more than 1°C/ky through this interval to account for the observed rate of ice recession.

  11. Actual geomorphological processes on hillslope viticulture from Axarquía in the Montes de Málaga (Spain).

    NASA Astrophysics Data System (ADS)

    Rodrigo Comino, Jesús; María Senciales González, José; Seeger, Manuel; Damián Ruiz Sinoga, José; Ries, Johannes B.

    2015-04-01

    Hillslope viticulture is one of the agricultural activities affecting the eco-geomorphological system. Specifically, in the vineyards of the Axarquía on the Montes de Málaga (Spain), where the popular Moscatel and Pedro Ximénez grapes are produced, several problems of degradation of the chemical and physical properties of the soils have been reported by several authors, but not real quantifications of sediment losses. Soils have developed mainly on Palaeozoic schists and slates with different degrees of metamorphism, but also include marbles, limestone, quartz and gneiss. On steep slopes (36-76%), surface rock fragment cover (45 to 75%) and occasional generation of rills and gullies characterize the principal geomorphological processes. Degradation processes are due to two causes: i) the concentrated heavy rainfall events during a few hours within no more than 30 days per year; ii) soil tillage of the vine-workers, removing vegetation cover under and around the vines. Anyhow, farmers take measures against soil erosion, such as building rills to canalize the surface flow (called 'sangrías') and small walls of stones ('albarradas') to reduce soil loss. Actual soil degradation as a consequence of intensive agricultural activities starting with Muslim ages (s. VIII-XV). The objective of this work is to show the geomorphological processes during summer, autumn and winter (2014-2015) on experimental plots along a hillslope in the south of Spain (Almáchar, Málaga). Six sediment traps (50 liters) with their respective collectors (60 liters) were installed in three different points along a hillslope exposed to south-west. After each rainfall, all sediments were collected and analyzed to calculate soil losses (g), surface flow (l) and the sediment concentration (g l-1). Furthermore, a meteorological station (rainfall, temperature, wind and air humidity) was installed close to the plot. Final results show elevated soil loss and surface flow rates with different

  12. [Platelet rich plasma versus oral paracetamol for the treatment of early knee osteoarthritis. Preliminary study].

    PubMed

    Acosta-Olivo, Carlos; Esponda-Colmenares, Francisco; Vilchez-Cavazos, Félix; Lara-Arias, Jorge; Mendoza-Lemus, Oscar; Ramos-Morales, Tomas

    2014-01-01

    Antecedentes: la osteoartrosis se caracteriza por dolor, rigidez articular y crepitación, con datos radiológicos específicos. El dolor se controla con analgésicos y antiinflamatorios no esteroides. En la actualidad, el plasma rico en plaquetas es una alternativa de tratamiento de esta enfermedad. Objetivo: comparar el efecto del plasma rico en plaquetas versus paracetamol en el tratamiento de pacientes con osteoartrosis de rodilla grado I. Material y métodos: ensayo prospectivo y experimental en el que se estudiaron 42 pacientes que se asignaron al azar a dos grupos. Al grupo 1 (experimental) se le indicaron 5 mL de plasma rico en plaquetas, en dos aplicaciones; el grupo 2 (control) se trató con 1 g de paracetamol oral cada 8 horas durante 30 días. Ambos grupos recibieron terapia física supervisada, con un tiempo de seguimiento total de seis meses. Para determinar las concentraciones de sangre periférica se tomaron muestras de IL-1β, TNF-a y TGF-β en plasma el día 0 y a los 6 meses. La valoración clínica se realizó con el Knee injury and Osteoarthritis Outcome Score (KOOS) al inicio y mensualmente durante el estudio. Resultados: los resultados de IL-1β y TNF-a no mostraron diferencia significativa entre los grupos tratados con plasma rico en plaquetas y paracetamol. La escala KOOS para el grupo 1 al inicio del tratamiento fue de 30.1 puntos y al finalizar el tratamiento 48.2 puntos, con mejoría clínica de 60%. Conclusiones: los pacientes tratados con plasma rico en plaquetas tuvieron un incremento significativo en las concentraciones séricas de TGF-β1 que se asoció con la mejoría clínica relacionada con el KOOS.

  13. [Perioperative risk factors associated with allogeneic blood transfusion in patients with hip fracture surgery].

    PubMed

    Durán-Nah, Jaime Jesús; Pastelín-Ruiz, Sofía Elisa; Miam-Viana, Emilio de Jesús

    2015-01-01

    Introducción: el objetivo es identificar los factores de riesgo asociados a la hemotransfusión alogénica en pacientes con cirugía de cadera realizada en un hospital general citadino, durante 2008 y 2009. Métodos: fueron considerados como casos 118 pacientes que recibieron sangre alogénica en el pre, el trans o en el postquirúrgico inmediato, y como controles 138 pacientes que tuvieron el mismo tipo de cirugía, pero no fueron hemotransfundidos. La relación entre variables se investigó utilizando un modelo de regresión logística del que se obtuvieron la razón de momios (RM) y los intervalos de confianza (IC) de 95 %. Resultados: se identificaron como factores de riesgo: el sangrado transquirúrgico mayor o igual a 400 ml (frente a < 400 ml, RM 5.68, IC 95 % 2.5 a 12.9, p = 0.007) y la concentración prequirúrgica de hemoglobina < 11 g/dL (frente a = 11 g/dL, RM 2.86, IC 95 % 1.5 a 5.6; p = 0.001); pero no la duración de la cirugía, el segmento femoral intervenido, la técnica quirúrgica ni la Hb postquirúrgica. Conclusiones: el sangrado transquirúrgico mayor o igual a 400 ml y la Hb prequirúrgica < 11 g/dL incrementaron el riesgo de hemotransfusión alogénica.

  14. [Etiology, clinical presentation and outcome of severe viral acute childhood encephalitis (ECOVE study)].

    PubMed

    Flores-Gonzalez, José C; Jordan-Garcia, Iolanda; Turon-Vinas, Eulàlia; Montero-Valladares, Cristina; Tellez-Gonzalez, Cinta; Fernandez-Carrion, Francisco; Garcia-Iniguez, Juan P; Onate-Vergara, Eider; Rodriguez-Nunez, Antonio

    2015-07-01

    Introduccion. Las encefalitis viricas son procesos raros y potencialmente graves, con etiologia diversa y no siempre identificable. El objetivo es describir las caracteristicas etiologicas, la presentacion clinica y la evolucion neurologica de las encefalitis viricas que ingresaron en las unidades de cuidados intensivos pediatricos (UCIP) en España. Pacientes y metodos. Estudio prospectivo multicentrico observacional. Se incluyeron los niños ingresados en 14 UCIP con diagnostico de encefalitis virica durante un periodo de tres años (2010-2013). Para el diagnostico etiologico se utilizo reaccion en cadena de la polimerasa y serologia a virus neurotropos en la sangre y el liquido cefalorraquideo. Se registraron los antecedentes personales, la presentacion clinica, la evolucion y la situacion neurologica en el momento del alta. Resultados. Se incluyeron 80 pacientes con edad media de 5 años; el 70%, varones. Los sintomas clinicos mas relevantes fueron disminucion de conciencia (86%), fiebre (82,4%), convulsiones (67%), vomitos (42%), cefalea (27%), agitacion (25%) y desorientacion (23%). Se llego al diagnostico etiologico en un 35%, y los mas frecuentes fueron virus herpes simple y enterovirus. La evolucion fue curacion sin secuelas en 55 pacientes (69%, sobre todo enterovirus, rotavirus y virus respiratorios), secuelas leves-moderadas en 19 (23,5%) y graves en seis (7,5%). Dos pacientes fallecieron. Conclusiones. En las UCIP españolas solo se realizo el diagnostico etiologico en un tercio de los niños con sospecha de encefalitis virica grave. A pesar de la gravedad clinica, hemos observado una tasa de mortalidad y morbilidad baja. La amplia mayoria son dados de alta de la UCIP con ninguna o escasa secuela neurologica.

  15. [Role of anaerobic blood culture in the simultaneous blood culture taking for the diagnosis of bacteremia].

    PubMed

    Guajardo-Lara, Claudia Elena; Saldaña-Ramírez, Martha Idalia; Ayala-Gaytán, Juan Jacobo; Valdovinos-Chávez, Salvador Bruno

    2016-01-01

    Introducción: la frecuencia de la septicemia va en aumento y su mortalidad es alta; por lo tanto, su detección, la identificación del microorganismo causal y su susceptibilidad son perentorias. Metodos: se revisaron los registros de 4110 botellas de cultivo de sangre obtenida de enero de 2013 a julio de 2014 de pacientes adultos en un hospital privado de tercer nivel. Resultados: se observó crecimiento de microorganismos en 559 cultivos (12.6 %). En 2648 hemocultivos (60 %) inoculados en pares de frascos uno con medio aeróbico y el otro anaeróbico (1324 sets), se detectó crecimiento en 182 frascos a los que les fueron inoculadas las muestras tomadas al mismo tiempo a 135 pacientes (13.7 %). En 86 pares de frascos con las muestras de 54 pacientes (40 %), el crecimiento solamente se dio en el frasco aeróbico (47.5 %); en 24 pares de frascos (13.19 %) tomados a 21 pacientes (15.5 %, p < 0.05), solamente hubo crecimiento en el frasco anaeróbico. En los hemocultivos de 32 de 60 pacientes con crecimiento en ambos frascos (53 %), el crecimiento se detectó primero en el frasco anaeróbico. Conclusiones: los hemocultivos anaeróbicos tienen una utilidad baja para la detección de bacteriemias por anaerobios estrictos; no obstante, en el 15.55 % de los pacientes estuvo presente el riesgo de pasar por alto la presencia de bacteriemia, y en 53 % de los pacientes con hemocultivos positivos, el diagnóstico de bacteriemia pudo establecerse de manera más temprana, lo que permitió anticipar con mejor precisión la toma de decisiones.

  16. [Not Available].

    PubMed

    Domínguez, Raúl; Garnacho-Castaño, Manuel Vicente; Maté-Muñoz, José Luis

    2016-06-30

    La fuerza influye directamente en el estado de salud y en la capacidad de fitness, motivo por el que el entrenamiento contra resistencias o resistance training (RT) se incluye dentro de aquellos programas de ejercicio encaminados a mejorar la salud y calidad de vida. Debido a que muchasenfermedades cursan con alteración de la masa y funcionalidad muscular y a que el RT es la principal modalidad de ejercicio encaminada a mejorar la función muscular, el objetivo de la presente revisión bibliográfica ha sido exponer las evidencias actuales sobre las adaptaciones delRT, así como su posible aplicación en patologías como la obesidad, diabetes, dislipemia, hipertensión, cáncer, Parkinson, esclerosis múltiple o fibromialgia. El RT en estas enfermedades puede aumentar los niveles de masa muscular, disminuyendo los niveles de masa grasa, los nivelesde ácidos grasos en sangre y la glucemia, incrementando la sensibilidad a la insulina, y disminuyendo los niveles de citokinas inflamatorias. El RT, además, mejora el gasto cardiaco y la funcionalidad endotelial, regulando la tensión arterial e incrementando el consumo de oxígeno. Las ganancias de fuerza muscular mejoran la funcionalidad y la calidad de vida, especialmente en población con una afectación neuromuscular grave, como pudieran ser los enfermos de esclerosis múltiple, fibromialgia o Parkinson. Por ello, el RT debe ser incorporado como parte del tratamiento en las personas que presentan determinado tipo de patologías.

  17. Molecular characterization, distribution, and dynamics of hepatitis C virus genotypes in blood donors in Colombia.

    PubMed

    Mora, Mónica Viviana Alvarado; Romano, Camila Malta; Gomes-Gouvêa, Michele Soares; Gutiérrez, Maria Fernanda; Carrilho, Flair José; Pinho, João Renato Rebello

    2010-11-01

    Hepatitis C virus (HCV) is a frequent cause of acute and chronic hepatitis and a leading cause for cirrhosis of the liver and hepatocellular carcinoma. HCV is classified in six major genotypes and more than 70 subtypes. In Colombian blood banks, serum samples were tested for anti-HCV antibodies using a third-generation ELISA. The aim of this study was to characterize the viral sequences in plasma of 184 volunteer blood donors who attended the "Banco Nacional de Sangre de la Cruz Roja Colombiana," Bogotá, Colombia. Three different HCV genomic regions were amplified by nested PCR. The first of these was a segment of 180 bp of the 5'UTR region to confirm the previous diagnosis by ELISA. From those that were positive to the 5'UTR region, two further segments were amplified for genotyping and subtyping by phylogenetic analysis: a segment of 380 bp from the NS5B region; and a segment of 391 bp from the E1 region. The distribution of HCV subtypes was: 1b (82.8%), 1a (5.7%), 2a (5.7%), 2b (2.8%), and 3a (2.8%). By applying Bayesian Markov chain Monte Carlo simulation, it was estimated that HCV-1b was introduced into Bogotá around 1950. Also, this subtype spread at an exponential rate between about 1970 to about 1990, after which transmission of HCV was reduced by anti-HCV testing of this population. Among Colombian blood donors, HCV genotype 1b is the most frequent genotype, especially in large urban conglomerates such as Bogotá, as is the case in other South American countries.

  18. [Prevalence for seropositivity for HIV, hepatitis B and hepatitis C in blood donors].

    PubMed

    Rivera-López, María Rebeca F; Zavala-Méndez, Celia; Arenas-Esqueda, Alfonso

    2004-01-01

    Despite utilizing different actions to render blood safe for transfusions, we continue to have the risk of transmitting some viral infections. For this reason, it is important to determine prevalence of infections due to HIV and hepatitis B and hepatitis C viruses in blood donors. Previous studies from Mexico indicate that HIV prevalence is 0.01 to 0.13%, while it is 0.11 to 1.22% for hepatitis B, and for hepatitis C, prevalence is 0.47 to 1.47%. We are checking the results of the screening tests (ELISA 3rd generation and chemiluminescent immunoassays) from blood donors studied at the Central Blood Bank (Banco Central de Sangre) at the Mexican Institute of Social Security's (IMSS) Twentieth First Century National Medical Center in Mexico City from 1995 to 2002. Reactive results were studied by confirmatory tests, Western Blot for HIV, AgHBs neutralization test for hepatitis B, and RIBA-HCV3.0 for hepatitis C. Reactive results from 513,062 blood donors confirmed for HV were 0.07%, reactive results and confirmation of hepatitis B from 511,733 blood donors were 0.13%, and reactive results and confirmation of hepatitis C from 511,115 blood donors were 0.31%. Rates obtained are low when compared with results of previous studies in Mexico for HIV, hepatitis B, and hepatitis C. It may be possible than these low rates indicate the positive impact obtained from preventive actions, better strategies of detection of blood donors with high risk, and the advantage of working with a fully automated test system with state-of-the-art technology.

  19. Ground-based RGB imaging to determine the leaf water potential of potato plants

    NASA Astrophysics Data System (ADS)

    Zakaluk, Robert F.

    The determination of plant water status from leaf water potential (Psi L) data obtained by conventional methods is impractical for meeting real time irrigation monitoring requirements. This research, undertaken first, in a greenhouse and then in the field, examined the use of artificial neural network (ANN) modeling of RGB (red green blue) images, captured by a ground-based, five mega pixel digital camera, to predict the leaf water potential of potato (Solanum tuberosum L). The greenhouse study examined cv. Russet Burbank, while the field study examined cv. Sangre. The protocol was similar in both studies: (1) images were acquired over different soil nitrate (N) and volumetric water content levels, (2) images were radiometrically calibrated, (3) green foliage was classified and extracted from the images, and (4) image transformations, and vegetation indices were calculated and transformed using principal components analysis (PCA). The findings from both studies were similar: (1) the R and G bands were more important than the B image band in the classification of green leaf pigment, (2) soil N showed an inverse linear relationship against leaf reflectance in the G image band, (3) the ANN model input neuron weights with more separation between soil N and PsiL were more important than other input neurons in predicting PsiL, and (4) the measured and predicted PsiL validation datasets were normally distributed with equal variances and means that were not significantly different. Based on these research findings, the ground-based digital camera proved to be an adequate sensor for image acquisition and a practical tool for acquiring data for predicting the PsiL of potato plants. Keywords: nitrogen, IHS transformation, chromaticity transformation, principal components, vegetation indices, remote sensing, artificial neural network, digital camera.

  20. Water resources of Taos County, New Mexico

    USGS Publications Warehouse

    Garrabrant, Lynn A.

    1993-01-01

    In Taos County, ground water generally is unconfined and moves toward the Rio Grande or perennial streams. Water quality is good except in some areas where water has high values of specific conductance and hardness and contains high concentrations of dissolved solids and fluoride. Most wells are completed in alluvial sediments of Quaternary and Tertiary age in the Costilla Plains. A few wells are completed in basalt of the Taos Plateau and in alluvium of stream channels in the Sangre de Cristo Mountains. Depths to water in wells range from less than 1 to 1,080 feet below land surface. Well yields range from 1 to 3,000 gallons per minute. Water levels in wells in Sunshine Valley dropped 5 to 50 feet between 1955 and 1970. Ground-water irrigation has since declined and water levels have risen. Surface-water records show the county is a net producer of water. The average discharge gained in the Rio Grande as it flows through the county was 271,700 acre-feet per year for water years 1931-89. The highest mean monthly discharge occurs in May or June due to snowmelt runoff. Water quality ranges from good in upstream reaches to fair in lower reaches. Surface water was the source for 93 percent of water withdrawn in 1990, but ground water was used for all public supply, domestic, and industrial purposes. The largest water use is irrigation. About 28,500 acres were irrigated in 1990; alfalfa, native pasture, and planted pasture accounted for 91 percent of this acreage.

  1. Trinidad's mismatched expectations. Planning and development review.

    PubMed

    Conway, D

    1984-11-01

    In 1974 petrodollars helped to boost living standards for many of the population of the Republic of Trinidad and Tobago. Yet, a failure to address the consequences of uncontrolled urbanization, especially in and around the capital, Port of Spain, threatens to undermine further improvements in the quality of Trinidadian life. Trinidad's urbanization has been associated with upward social mobility and a burgeoning middle class, such that social aspirations and spatial mobility tend to coincide. Thus, internal migration has involved a heterogeneous mixture of classes with the common denominator being a desire to improve one's standard of living. For most this means residence in or proximity to Port of Spain, the country's commercial, administrative, and cultural hub. Migration into and within Port of Spain and northwest corridors of West and East St. George County has contributed to several tricky problems, overwhelming regional planning efforts, inflating the costs of houses and land, and accelerating social alienation among urban Trinidadians. Problems could have been eased if government planning had given adequate recognition to spatial variations in societal organization, regional economic structures, and resource distribution. Trinidad changed markedly in the years 1974-81. New wealth has brought its own problems and old problems have worsened for lack of attention. The idea of decentralized growth poles at Sangre Grande, Point Fortin, La Brea, and Guayaguayare-Galeota now seems impossible to realize. The Capital region has for 10 years been absorbing a larger share of the population, now roughly half the total. It generates virtually all the island's employment opportunities and attracts the lion's share of private sector investment. Overcrowding in residences, unsanitary drainage, shortages of potable water, traffic congestion, and air pollution all have reduced the quality of life compared to 10 years ago. From 1974 onward the issue of economic development no

  2. [In Process Citation].

    PubMed

    Martín Álvarez, Estefanía; Jiménez Cabanillas, María Victoria; Peña Caballero, Manuela; Serrano López, Laura; Kajarabille, Naroa; Díaz Castro, Javier; Ochoa Herrera, Julio José; Maldonado Lozano, José

    2016-01-01

    Introducción: el recién nacido prematuro de muy bajo peso (RNMBP) es inmunológicamente inmaduro y además presenta una alteración de las barreras naturales de defensa. Objetivo: evaluar los efectos que pueda tener la administración de calostro orofaríngeo, administrado durante los primeros 15 días posnatales, sobre los niveles de inmunoglobulina A (IgA) sérica en recién nacidos prematuros de muy bajo peso durante el primer mes de vida. Material y métodos: se desarrolló un estudio de intervención no aleatorizado con grupo control, en el que se incluyeron 38 recién nacidos con ≤ 32 + 6 semanas de gestación y/o menores de 1.500 g de peso. Los sujetos recibieron 0,2 ml de calostro de su madre cada 4 h, iniciándose el procedimiento en las primeras 24 h de vida hasta el 15.o día postnatal. Se midieron los niveles de IgA en la sangre al nacimiento, 3. er , 15.o y 30.o días de vida. Se registraron datos perinatales al nacimiento y durante el periodo de seguimiento. Resultados: IgA sérica aumentó de forma estadísticamente significativa en el grupo de intervención (M1 15,84 μg/ml, M2 20,07 μg/ml, M3 23,65 μg/ml, M4 30,34 μg/ml, p 0,001) y en el grupo control (M1 12,48 μg/ml, M2 16,48 μg/ml, p 0,018; M3 19,41 μg/ml, M4 22,48 μg/ml, p 0,001). Al mes de vida, los niveles de IgA sérica fueron significativamente mayores en el grupo de intervención que en el grupo control (p 0,026). Conclusiones: este estudio sugiere que la administración de calostro orofarínge. PMID:27238778

  3. [In Process Citation].

    PubMed

    Durán Agüero, Samuel; Fernández Godoy, Eloina; Carrasco Piña, Elena

    2016-01-01

    Introducción: la hiperglicemia es la característica principal de la diabetes (DM). La restricción de CHO en la dieta presenta el mayor efecto en la disminución de los niveles de glucosa en sangre tanto en DM 1 y 2.Objetivo: asociar la ingesta de macro y micronutrientes con el control metabólico de pacientes con diabetes tipo 2.Material y métodos: se entrevistó a 714 pacientes diabéticos tipo 2 de ambos sexos, entre 27 y 90 años, en centros de salud familiar de Santiago de Chile. Se les aplicó una encuesta alimentaria y una evaluación antropométrica. Se realizó prueba de regresión logística, se estimó además el valor del Odds Ratio (OR) y su correspondiente intervalo de confianza (IC).Resultados: el IMC promedio fue de 30,8 ± 5,7 kg/m2, el 29,8% de los sujetos tenía una HbA1c compensada. Se puede observar que solo la ingesta elevada de carbohidratos (percentil 75) se asoció con un incremento en el riesgo de tener HbA1c elevada OR = 2,7 (IC 95% 1,5-4,8; p < 0,001).Conclusiones: la ingesta elevada de carbohidratos de rápida absorción, altos en sacarosa y bajos en fibra se asocia como factor de riesgo en el incremento de HbA1c. La ingesta total de energía y el patrón de alimentación saludable se debe priorizar sobre la distribución de macronutrientes. Es importante la asesoría de un experto en nutrición especializado en diabetes quien, en colaboración con el equipo médico, debe determinar el tratamiento para cumplir con los objetivos individuales del paciente. PMID:27019245

  4. [Allergic rhinitis in asthmatic patients].

    PubMed

    Reyes, Paola; Larreal, Yraima; Arias, Julia; Rincón, Enrique; Valero, Nereida

    2014-01-01

    Antecedentes: la rinitis alérgica y el asma bronquial son procesos inflamatorios crónicos de las vías respiratorias, con una correlación que varía entre 28 y 78%. Objetivos: determinar la prevalencia de rinitis alérgica en pacientes asmáticos y clasificarla según las guías Rinitis Alérgica y su Impacto en Asma (ARIA), así como detectar las concentraciones séricas de IgE total y la existencia de eosinofilia nasal y en sangre periférica. Material y método: estudio en el que pacientes asmáticos entre 7 y 14 años de edad, consultantes del servicio de Pediatría del Hospital General del Sur Dr. Pedro Iturbe, Maracaibo, Estado Zulia, Venezuela, fueron encuestados acerca de signos y síntomas sugerentes de rinitis alérgica y su efecto en la calidad de vida. Se tomaron muestras sanguíneas e hisopado nasal para hacer las determinaciones objeto de estudio. Resultados: se evaluaron 60 pacientes asmáticos, 73.3% del sexo masculino y 70% escolares. La prevalencia de rinitis alérgica se estableció en 93.3%, el tipo más frecuente según ARIA fue el intermitente leve, con 42.8%. El signo clínico más frecuente fueron las ojeras alérgicas (86.6%) y el síntoma predominante fue el goteo nasal acuoso (83.3%), la afectación en cuanto a calidad de vida estuvo representada por trastornos del sueño (39.2%). El 85.7% de los encuestados tuvo porcentajes de eosinófilos mayores a 3% y 75% tuvo valores mayores de 100 UI de IgE total sérica. El 61.9% de las muestras de moco nasal de pacientes con rinitis mostró porcentajes de eosinófilos mayores a 10%. Conclusión: existe alta prevalencia de rinitis alérgica en asmáticos confirmada mediante pruebas de laboratorio que evidencian una respuesta inflamatoria mediada por IgE.

  5. Physical fitness, adiposity and testosterone concentrations are associated to playing position in professional basketballers.

    PubMed

    Ponce-González, Jesús Gustavo; Olmedillas, Hugo; Calleja-González, Julio; Guerra, Borja; Sanchis-Moysi, Joaquín

    2015-06-01

    Los efectos de jugar al baloncesto sobre las concentraciones basales de testosterona y cortisol, así como su asociación a la composición corporal y el rendimiento físico aún están por determinarse. Objetivo: el principal objetivo de este estudio fue determinar los efectos de la posición de juego sobre la condición física, el porcentaje de grasa coporal y el perfil hormonal en jugadores de baloncesto profesionales (BP). Metodología: la capacidad de salto (SJ, CMJ y ABK), la velocidad en 30 m y el VO2max en tapiz rodante se midió en 12 varones BP (24,1 años) pertenecientes a la primera división de la liga de España (ACB). El porcentaje de grasa corporal se determinó a partir de la antropometría, y las concentraciones de hemoglobina, glucosa, testosterona y cortisol se midieron a partir de muestras de sangre en ayunas. Los baloncestistas se dividieron en tres grupos en función de las posiciones de juego: bases (GU), aleros (FW) y pivots (CE). Resultados: GU tuvo mayor porcentaje de grasa corporal (% GC) que CE (p < 0,05). CE desarrolló mayor impulso positivo mecánico que GU en todos los tipos de saltos (p < 0,05) y logró mayor potencia instantánea máxima que GU y FW en el SJ y ABK (p < 0,05). Los pivots tenían más testosterona plasmática que los bases (p < 0,05). Todos los grupos mostraron similar VO2 máx. Conclusión: la posición de pivots fue asociada a una menor adiposidad y a una mayor capacidad de salto en comparación con los bases. Todas las posiciones de juego indujeron un efecto similar sobre la potencia aeróbica.

  6. U-Pb Zircon Geochronology of Hermit's Peak Batholith Granite, Northern New Mexico: Implications for Tectonic Quiescence at 1.4 GA

    NASA Astrophysics Data System (ADS)

    Lindline, J.; Cedillo, D. N.; Romero, A.

    2012-12-01

    The Hermit's Peak batholith, a Proterozoic metamorphic-plutonic massif in the southern Sangre de Cristo Mountains, is located in the transition zone between the Yavapai and Mazatzal Precambrian provinces. We conducted zircon geochronology at the University of Arizona's LaserChron Center on granitic phases within the Hermit's Peak batholith to establish the timing of granite magmatism relative to Proterozoic orogenesis. Two analyses (core and rim) of more than 20 zircon crystals were incorporated into a final age calculation for each sample. Within the batholith, early granitoid intrusions form centimeter- to meter-wide coarse-grained tabular sheets and layers within Paleoproterozoic host rock gneisses. The intrusions were deformed during isoclinal folding along with their host rocks, suggesting that the early granites are pre- or syntectonic with contractional deformation associated with Yavapai-Mazatzal collision. These granites show a fine- to medium-grained anhedral granular texture with quartz microstructures indicative of dynamic strain and solid state deformation, including undulose extinction, subgrain development, and serrated grain boundaries. All zircon crystals are euhedral with aspect ratios of 2:1 to 3:1 and lengths ranging from 100-300 μm. Cathodoluminescence imaging shows that most crystals have oscillatory zonation indicating they are igneous in origin. Elemental U/Th ratios are all low (<10) indicating an igneous origin as well. Most crystals show a bright rim (high U) suggesting a late-stage fluid interaction. However, there was no discordance between core and rim age analyses. The granitic gneiss yielded a weighted mean 207Pb/206Pb age of 1.705 ± 0.017 Ga placing its emplacement prior to or early in the Mazatzal orogeny. A small (< 1.0 km2) nonfoliated coarse-grained anhedral granular granite intrudes the granitic gneiss. All zircon crystals are euhedral with aspect ratios of 2:1 to 3:1 and lengths ranging from 100-300 μm. Cathodoluminescence

  7. LIPID PROFILE AND ASSOCIATED FACTORS AMONG ELDERLY PEOPLE, ATTENDED AT THE FAMILY HEALTH STRATEGY, VIÇOSA/MG.

    PubMed

    Danésio de Souza, Jacqueline; Queiroz Ribeiro, Andréia; Oliveira Martinho, Karina; Silva Franco, Fernanda; Vidal Martins, Marcos; Gonçalves Rodrigues, Meirele; Wick, Jeannette Y; Araújo Tinôco, Adelson Luiz

    2015-08-01

    Introducción: el envejecimiento de la población ha ido acompañado de cambios epidemiológicos de la población brasileña, destacando el crecimiento continuo de la prevalencia de enfermedades crónicas no transmisibles, especialmente cardiovasculares o de la arteria coronaria, como resultado de los cambios en el perfil lipídico de las personas mayores. Objetivo: describir las variables antropométricas, estilo de vida y composición corporal como factores de comportamiento y su asociación con los cambios en el perfil lipídico de las personas de edad avanzada. Metodología: la muestra incluyó a 402 participantes que asistieron a la Estrategia Salud de la Familia, Viçosa (MG), a los que se aplicó un cuestionario con información socio-demográfica, de comportamiento y de estilo de vida. Se recogió una muestra de sangre para obtener las fracciones de lípidos, y se midió el porcentaje de peso, talla, circunferencia de la cintura y grasa corporal. La regresión lineal múltiple se realizó para identificar factores independientemente asociados con los cambios en cada una de las fracciones de lípidos seleccionados. Resultado: los factores asociados de forma independiente con un aumento de los niveles de colesterol total fueron la presencia de conducta sedentaria, un porcentaje de grasa corporal alto, mayor altura de la cintura y una mayor circunferencia de la cintura. El consumo de bebidas alcohólicas y una proporción cintura-cadera más alta se mantuvo asociado de forma independiente con la disminución de los niveles de lipoproteínas de alta densidad. El aumento de la circunferencia de la cintura se asoció de forma independiente con valores bajos de los niveles de lipoproteínas de baja densidad. El valor del aumento de triglicéridos se asocia de forma independiente con una mayor relación cintura-cadera, un mayor índice de masa corporal y tabaquismo. Conclusión: los factores de riesgo modificables asociados con un perfil lipídico cambiado deben

  8. [SHORT TERM EFFECTS ON LIPID PROFILE AND GLYCAEMIA OF A LOW-FAT VEGETARIAN DIET].

    PubMed

    Quiles, Laura; Portolés, Olga; Sorlí, José Vicente; Corella, Dolores

    2015-07-01

    Introducción: en estudios observacionales, las dietas vegetarianas se han asociado con menor riesgo de enfermedad cardiovascular y un perfil lipídico más favorable en las personas que siguen estas dietas a largo plazo pero sus efectos a corto plazo son menos conocidos. Objetivo: analizar el efecto a corto plazo en población mediterránea previamente no vegetariana de una dieta vegetariana baja en grasas sobre el perfil lipídico y la glucemia. Métodos: se realizó un estudio de intervención nutricional en 159 voluntarios (42 hombres y 117 mujeres) administrando un patrón de dieta completa lacto-vegetariana baja en grasa (20%). Se proporcionó un menú diario completo en condiciones de régimen de internado estricto durante 15 días. Se realizaron extracciones de sangre en ayunas antes y después de la intervención dietética y se determinó el colesterol total, C-HDL, C-LDL, triglicéridos y glucemia. Se emplearon modelos multivariantes de medidas repetidas. Resultados: tras la intervención dietética se detectaron reducciones estadísticamente significativas en el colesterol total (-17,54 ± 37,14 mg/dl), C-LDL (-9,33 ± 34,29 mg/ dl), C-HDL (-5,32 ± 12,16 mg/dl), y triglicéridos (-18,92 ± 50,50 mg/dl) que permanecieron tras ajustar por edad y sexo. También se produjeron cambios significativos de peso. El ajuste adicional por los cambios en el índice de masa corporal (IMC) restó significación a la disminución de los triglicéridos (P = 0.067). Conclusión: la dieta lacto-vegetariana baja en grasa a corto plazo produce descensos favorables y significativos de colesterol total, C-LDL (independientes de la pérdida de peso) y triglicéridos (mediados por la pérdida de peso). También produjo un descenso esperable de C-HDL al ser reducida en grasa.

  9. Effects of exercise on inflammation in cardiac rehabilitation.

    PubMed

    Roca-Rodríguez, María del Mar; Garrido-Sánchez, Lourdes; García-Almeida, Jose Manuel; Ruiz-Nava, Josefina; Alcaide-Torres, Juan; Gómez-González, Adela; Montiel-Trujillo, Angel; Tinahones-Madueño, Francisco

    2015-06-01

    Introducción: a los pacientes con riesgo cardiovascular se les recomiendan programas de pérdida de peso y dieta saludable, pero la eficacia de estos programas a la hora de reducir la mortalidad es controvertida. Objetivo: examinar los efectos agudos y a largo plazo de un programa de rehabilitación cardíaca de dos meses de duración sobre las quemocinas relacionadas con la inflamación en pacientes con enfermedad cardiovascular. Diseño: estudio de cohortes prospectivo. Métodos: se estudiaron 26 pacientes con enfermedad cardiovascular inscritos en un programa de rehabilitación cardíaca basado en intervenciones nutricionales y de ejercicio. Se analizaron el estilo de vida y variables clínicas, metabólicas e inflamatorias. Resultados: 88,5% eran hombres y la edad media fue de 54,9 ± 7,8 años. Al final del programa de rehabilitación cardíaca las variables del perfil glucémico y lipídico descendieron, excepto el colesterol de lipoproteínas de alta densidad, que aumentó. Ácido úrico, interleucina-6, interleucina-1 beta, adiponectina y leptina se mantuvieron estables. Interleucina-6 correlacionó positivamente con proteína C reactiva y negativamente con glucosa en sangre. Interleucina-1 beta correlacionó positivamente con proteína C-reactiva y negativamente con las cifras de presión arterial. Encontramos correlaciones significativas entre los cambios en interleucina-6 e interleucina- 1 beta y los cambios en los equivalentes metabólicos y proteína C-reactiva, antes y después del programa de rehabilitación cardíaca. No se observaron correlaciones significativas con peso, circunferencia de cintura o masa grasa. Conclusiones: la rehabilitación cardiaca mejora las variables antropométricas, las cifras de presión arterial, así como el perfil de lípidos y los resultados de la ergometría. Sin embargo, no se observaron cambios con respecto al estado inflamatorio.

  10. FISH OIL AND VITAMIN E CHANGE LIPID PROFILES AND ANTI-LDL-ANTIBODIES IN TWO DIFFERENT ETHNIC GROUPS OF WOMEN TRANSITIONING THROUGH MENOPAUSE.

    PubMed

    Alves Luzia, Liania; Mendes Aldrighi, José; Teixeira Damasceno, Nágila Raquel; Rodrigues Sampaio, Geni; Aparecida Manólio Soares, Rosana; Tande Silva, Isis; De Queiroz Mello, Ana Paula; Ferreira Carioca, Antonio Augusto; Ferraz da Silva Torres, Elizabeth Aparecida

    2015-07-01

    Introducción: diversos estudios han investigado la relación entre la transición a la menopausia y las enfermedades cardiovasculares. Generalmente, la población de etnia blanca posee bajos niveles de factores de riesgo coronarios, particularmente dislipidemia, hipertensión, obesidad, diabetes y bajas tasas de mortalidad por enfermedades del corazón en comparación con la población de etnia negra. Además, varios estudios demostraron efectos cardioprotectores y antiinflamatorios provenientes de ácidos grasos poliinsaturados omega-3 (ácido eicosapentaenoico y ácido docosahexaenoico) de origen marino. El objetivo del estudio fue investigar el efecto de la suplementación de omega-3 combinado o no con vitamina E en biomarcadores oxidativos y perfiles lipídicos en mujeres blancas y no blancas con dislipidemia en transición hacia la menopausia. Métodos: fue realizado un estudio randomizado, duplo- ciego, placebo-controlado. Setenta y cuatro mujeres elegibles fueron escogidas para recibir: aceite de pescado, aceite de pescado con vitamina E y placebo durante tres meses. Fueron recogidas muestras de sangre en de referencia, 45 y 90 días para realizar exámenes bioquímicos y de biomarcadores para estrés oxidativo. Las variables socioeconómicas y de estilo de vida fueron recogidas por medio de cuestionarios estandarizados. Resultados: después de 90 días, el grupo tratado con aceite de pescado con vitamina E tuvo una disminución significativa para colesterol total y LDL-C. Además, hubo una disminución de anticuerpos anti-LDL después de 45 días. La concentración de plasma TBARS aumentó después de 90 días en el grupo que recibió solamente aceite de pescado, comparado con los grupos placebo y aceite de pescado con vitamina E. Todos los efectos observados fueron independientes del grupo étnico. Conclusión: la suplementación con aceite de pescado y vitamina E redujo el colesterol total y LDL-C, pero tuvo un efecto opuesto en el estrés oxidativo

  11. [Factors affecting oxidative damage in obese children: an exploratory study].

    PubMed

    Rentería, Ivan; Arenas Berumen, Ever; Arellano García, María Evarista; Carrasco-Legleu, Claudia Esther; De León-Fierro, Lidia Guillermina; Arenas-Berumen, Enrique Alejandro

    2015-04-01

    Introducción: La obesidad es un trastorno metabólico que crea condiciones oxidantes, las cuales pueden generar niveles elevados de estrés fisiológico, así como una perturbación en el estado de oxidación-reducción celular conocido como Estrés Oxidativo. Objetivo: Examinar la asociación entre el daño en el ADN cromosómico y la capacidad antioxidante total (TAC) en niños clasificados con obesidad severa. Métodos: En el estudio participaron 11 niños con edad e índice de masa corporal promedio de 9.5±1.2 años y 27.7±3.3 kg/m2, respectivamente, de quienes se obtuvieron muestras de sangre entera venosa y se analizó algunos factores de riesgo característicos del síndrome metabólico, así como el número de sitios abásicos (SA) en la molécula de ADN y los niveles de CAT. Los biomarcadores se determinaron utilizando técnicas espectrofotométricas y de ensayo ELISA. Resultados: Se reconocieron en promedio 4.0±4.1x105 sitios abásicos en la molécula de ADN y un nivel de concentración en plasma sanguíneo de la Capacidad Antioxidante Total de 0.218±0.03 mmol/L, donde se obtuvo una correlación inversa entre ambas variables (r = - 0.63, p = 0.038, r2 = 0.4). Advirtiéndose un desequilibrio del estado de reducción-oxidación (REDOX) celular. Conclusión: Los valores altos de sitios abásicos y bajos niveles de concentración de la Capacidad Antioxidante Total en presencia de obesidad severa sugieren la existencia de estrés oxidativo, lo que podría considerarse como un factor de riesgo alto, vinculado al desarrollo temprano de comorbilidades asociadas a la obesidad.

  12. Effect of computer radiation on weight and oxidant-antioxidant status of mice.

    PubMed

    Pei, Xuexian; Gu, Qijun; Ye, Dongdong; Wang, Yang; Zou, Xu; He, Lianping; Jin, Yuelong; Yao, Yingshui

    2014-10-20

    Objetivos: Explorar los efectos de la radiación de ordenador sobre el peso y el estado oxidativo-antioxidativo de los ratones, y además para confirmar si la vitamina C tiene efectos protectores contra la radiación de ordenador. Métodos: Sesenta ratones machos adultos ICR fueron aleatoriamente divididos en seis grupos. Cada grupo recibió un tratamiento diferente del modo siguiente: el grupo A fue el grupo de control, el grupo B recibió vitamina C, el grupo C fue sometido a una exposicion a la radiacion de ordenador de 8 h/día, el Grupo D recibió vitamina C y fue sometido a una exposicion a la radiacion de ordenador de 8 h/día, el Grupo E fue sometido a una radiación de ordenador de 16 h/día, el grupo F recibió vitamina C y fue sometido a una exposicion a la radiacion de ordenador de 16 h/día. Al cabo de siete semanas, los ratones fueron ejecutados para extraer las muestras de sangre, para detectar la capacidad antioxidante total (T-AOC) y el contenido de fosfatasa alcalina (ALP) en suero o en tejido hepático fue determinado mediante ELISA. Resultados: No se encontraron diferencias en cuanto a cambio de peso entre los seis grupos diferentes. En los grupos C, D y F, el nivel en de T-AOC en tejido hepático fue más alto que en el grupo A. En los grupos B, C y E, el nivel de ALP en suero fue más bajo que en el Grupo A (P < 0,05). Conclusiones: El estudio indican que la radiación de ordenador puede tener un efecto adverso en los niveles de T-AOC y ALP de ratones, y que la vitamina C tendría un efecto protector contra la radiación del ordenador.

  13. The association of selenium status with thyroid hormones and anthropometric values in dyslipidemic patients.

    PubMed

    Carvalho, Roberta F; Rosa, Glorimar; Huguenin, Grazielle V B; Luiz, Ronir R; Moreira, Annie S B; Oliveira, Glaucia M M

    2015-04-01

    Contexto: El selenio (Se) es un micronutriente esencial que realiza las funciones fisiológicas en el metabolismo de la hormona tiroidea y pueden tener una asociación con las variables antropométricas pertinentes a la enfermedad cardiovascular. Objetivo: Estudiar la asociación entre el estado de Se, hormonas tiroideas y las variables antropométricas en pacientes con dislipidemia. Métodos: Ochenta y tres pacientes fueron evaluados en un estudio transversal. Se analizaron muestras de sangre para Se y hormonas tiroideas. Las medidas antropométricas fueron tomadas, y la ingesta de la dieta Se fue investigado. Resultados: La media de las concentraciones de Se en plasma fueron bajas en los pacientes, a 88,7 ± 16,7 mg / l. Se encontró que los pacientes con niveles plasmáticos de Se ≥ 95 mg / L de tener un índice de masa corporal (IMC) (30.74 ± 4.31 vs 27.68 ± 5.63 kg / m 2, P = 0,02) y la relación cintura-estatura (0,65 ± 0,05 vs 0,59 ± 0,07, P = 0,003) en comparación con aquellos con concentraciones entre 80 y 94 g / l. Ingesta de Se asoció positivamente con relación T3L / T4L (r = 0,273, p = 0,03), índice de masa corporal (r = 0,257, P = 0,04) y WC (r = 0,299, P = 0,02). Conclusión: Se encontró que los pacientes con las más altas concentraciones de Se en plasma normal tener incrementos en las variables antropométricas que investigamos. Hay una necesidad de un mayor estudio para dilucidar estos hallazgos. Además, se encontró una asociación positiva entre el consumo de Se y la forma más metabólicamente activa de las hormonas tiroideas.

  14. On the Origin of the Crestone Crater: Low-Latitude Periglacial Features in San Luis Valley, Colorado

    NASA Astrophysics Data System (ADS)

    Schwans, E.; Meng, T. M.; Prudhomme, K.; Morgan, M. L.

    2015-12-01

    Located within the northern boundary of the Great Sand Dunes National Park is the Crestone Crater, a elliptical bowl-shaped feature consisting of a raised rim surrounding a central depression. The elongate crater has an approximate diameter of 100 m and reaches a depth of 10 m at its center relative to its rim, which rises 10 m above the elevation of the surrounding surface. Its precise origin is largely unknown and has perplexed regional geologists and residents of Crestone, Colorado for more than 80 years. This project used on-site and remote geophysical methods to characterize the processes that led to the geomorphologic surface expression observed today. Formation hypotheses examined encompass extraterrestrial, eolian, and periglacial processes. Field methods included a new gravity survey and reanalysis of gravity data collected in a previous student investigation of the feature. Additionally, a recent LiDAR dataset spanning San Luis Valley was examined to analyze the main structure, similar features in the area, and surrounding eolian and alluvial surfaces. An extraterrestrial origin, as suggested by numerous previous investigators, was deemed unlikely due to the non-unique gravity signature of the crater, its topographic similarity to many other like features identified in San Luis Valley, as well as its failure to excavate below the elevation of the surrounding surface. Furthermore, the expression of confirmed eolian landforms in San Luis Valley indicates that eolian processes alone would not produce such a prominent form in the level of vegetation observed. Proximal glacial deposits in the Sangre de Cristo Mountains show that the windblown sand in which all these features are clustered is adjacent to areas of past glaciations, and thus would have been affected by freeze-thaw cycles and thin, localized permafrost. Ice extent maps provided by the Colorado Geological Survey, as well as research on the timing of the formation of the Great Sand Dunes reinforce

  15. [Genetic variants in miRNAs and its association with breast cancer].

    PubMed

    Méndez-Gómez, Susana; Ruiz Esparza-Garrido, Ruth; Velázquez-Flores, Miguel; Dolores-Vergara, Maria; Salamanca-Gómez, Fabio; Arenas-Aranda, Diego Julio

    2014-01-01

    Antecedentes: en México, el cáncer de mama es la primera causa de muerte por cáncer en la mujer. A nivel molecular, los RNAs no codificantes y, en particular, los microRNAs, han tomado un papel importante en el origen y crecimiento de esta neoplasia. En población anglosajona se han reportado diversas variantes genéticas en los genes que codifican los microRNAs y en sus blancos, que se asocian con esta enfermedad. En la población mexicana se desconoce la existencia de estas u otras variantes; por eso su identificación en nuestra población es decisiva para comprender mejor la patogénesis del cáncer y contribuir a establecer una mejor estrategia diagnóstica. Objetivo: buscar y analizar variantes genéticas de tipo SNPs en cinco genes que codifican microRNAs y en tres sitios blancos de estos relacionados con predisposición al cáncer de mama, de mujeres mexicanas con o sin esta neoplasia. Material y métodos: estudio retrospectivo y longitudinal en el que se aisló ADN de tumores mamarios, tejido adyacente al tumor y sangre periférica de mujeres mexicanas con o sin cáncer. A partir del ADN se amplificaron y secuenciaron cinco genes de microRNAs y tres sitios blanco de estos en los que se han reportado variantes genéticas asociadas con el cáncer de mama en población anglosajona. Resultados: en las muestras estudiadas se identificaron siete polimorfismos de un solo nucleótido (SNPs). Dos son variantes no descritas que se encontraron sólo en mujeres con cáncer. Conclusión: las nuevas variantes identificadas pueden ser factores de predisposición genética para cáncer de mama en nuestra población. Para conocer cuál es la participación de estas variantes en el desarrollo, establecimiento y progresión del cáncer de mama se necesita experimentar más.

  16. Snow, the Great River, and the Desert

    NASA Astrophysics Data System (ADS)

    Rango, A.

    2005-12-01

    While many major rivers around the world originate from alpine snowpacks in mountain regions, some experience the extreme contrast of flowing through harsh desert environments downriver. One such stream is the Rio Grande which rises in the San Juan and the Sangre de Christo mountains of southern Colorado and northern New Mexico. Eventually, the snow fed Rio Grande flows through North America's largest desert, the Chihuahuan Desert in New Mexico, Texas, and Mexico, and simultaneously becomes part of the border between the United States and Mexico. As is often true, urban areas develop along the river corridors rather than in more inaccessible mountain regions. This demographic preference tends to isolate the vast majority of population in the Rio Grande, who are dependent on water for their livelihoods, from the mountain snowpacks where the flow is generated. Ironically then, snow is seldom viewed as the source of the much needed water flowing through the desert by the majority of the basin's population. In arid regions of the western U.S., water demand far exceeds the water supply, and water use is apportioned under the doctrine of prior appropriation with the oldest right getting the first use of water. The increasing population in urban areas does not usually have a right to use the water flowing through the desert unless water rights have been purchased by municipalities from the major category of water user in these basins, namely, irrigated agriculture. In the entire Rio Grande basin, irrigation makes up 80% of the consumptive use of water. Additionally, basin compacts and international treaties apportion water between states and countries. Because these formal agreements were based on above average runoff years, there is little flexibility in changing the use of water, particularly in dry to normal runoff years. Most of the older water rights in the Rio Grande, especially the upper basin, are supplied by snowmelt. This leaves the lower basin to depend upon

  17. SELENIUM IN DYSPHAGIC PATIENTS WHO UNDERWENT ENDOSCOPIC GASTROSTOMY FOR LONG TERM ENTERAL FEEDING.

    PubMed

    Santos, Carla Adriana; Fonseca, Jorge; Carolino, Elisabete; Lopes, Teresa; Guerreiro, António Sousa

    2015-12-01

    Introducción y objetivos: los pacientes con gastrostomía endoscópica (GEP) presentan malnutrición calórica- proteica, pero poco se conoce sobre la deficiencia de selenio. Estudiamos la evolución del selenio sérico en el momento de la GEP y después 4 y 12 semanas. Además, evaluamos la evolución de albúmina, transferrina, índice de masa corporal (IMC) y la influencia de la enfermedad subyacente. Métodos: obtenemos una muestra de sangre antes de la gastrostomía (T0), y después de 4 (T1) y 12 (T3) semanas. El selenio fue valorado mediante GFAAS (Furnace Atomic Absorption Spectroscopy). Los enfermos consumieron alimentos de preparación doméstica. Los pacientes fueron estudiados como un grupo y después separados en dos grupos: cánceres de cabeza y cuello (CCC) y disfagia neurológica (DN). Resultados: 146 enfermos (89 hombres), entre 21‑95 años: CCC-56, DN-90. Valores normales de selenio en 79% (n = 115), albúmina baja: 77 enfermos, transferrina baja: 94, las dos proteínas bajas: 66, IMC bajo: 78. El selenio ha demostrado una evolución lenta en el 82% de los enfermos presentando selenio normal en T3. Las proteínas séricas incrementaron sus valores en T0-T3, la mayoría de los enfermos alcanzó niveles normales. La enfermedad subyacente, CCC o DN, se relacionó con las proteínas, pero no con el selenio. Conclusiones: el selenio sérico bajo es poco común antes de la gastrostomía; después de 4 y 12 semanas de nutrición enteral no tiene relación con las proteínas séricas ni con la enfermedad que causa la disfagia. La nutrición con alimentación de preparación doméstica es suficiente para prevenir o corregir la deficiencia de selenio de la mayoría de los enfermos.

  18. SERUM CONCENTRATION OF NITRIC OXIDE IN WOMEN SMOKERS AND NONSMOKERS WITH OVERWEIGHT.

    PubMed

    Vieira van Keulen, Henriqueta; da Silva Gomes, Arthur; Cardoso Fernandes Toffolo, Mayla; Esteves Oliveira, Erick; Cristian da Silva, Luan; Cristina Potente Dutra Luquetti, Sheila; Ferreira, Ana Paula; Silva de Aguiar, Aline

    2015-10-01

    Objetivo: evaluar la concentración sérica de NO en las mujeres con sobrepeso, fumadoras (SG) y no fumadoras (GSN). Método: se recogieron muestras de sangre de las fumadoras (n = 20) y no fumadoras (n = 18) para obtener el suero, y se almacenaron a -80 °C hasta su análisis. NO se evaluó mediante la medición total de nitrito, determinado por el método Greiss. Fue adoptado como referencia de 24,4 mol/L, valor medio que se encuentra en un estudio con sujetos sanos sin exceso de peso. Se utilizó la prueba t de Student para comparar las medias de edad y la circunferencia de la cintura, así como la prueba de Mann-Whitney para comparar la mediana de las concentraciones de nitrito, número de cigarrillos/día y el Índice de Masa Corporal. Hemos adoptado un nivel de significación de p < 0,05. Resultados: la mediana de SG nitrito fue 16,53 (2,79- 69,72) mol/L, mientras que en NSG fue 10,85 (1,44-43,25) mol/L (p = 0,028). El IMC valor de la mediana de SG y NSG fue, respectivamente, 29,50 (25,00-38,14) kg/m2 y 30,68 (25,10-36,98) kg/m2 (p = 0,530), siendo clasificado como sobrepeso. Los datos muestran que el nitrito promedio estuvo por debajo del valor estimado para individuos sanos. Conclusiones: los resultados indican una disminución de los metabolitos NO en las mujeres con exceso de peso, independientemente de si son fumadoras o no. A pesar de la diferencia significativa entre los grupos, estas mujeres tenían valores muy por debajo del valor de referencia del NO para las mujeres sanas. Por lo tanto, parece que el fumar no interfiere en los niveles de nitritos en pacientes que ya están comprometidas por la obesidad.

  19. [SNP-19 genotypic variants of CAPN10 gene and its relation to diabetes mellitus type 2 in a population of Ciudad Juarez, Mexico].

    PubMed

    Loya Méndez, Yolanda; Reyes Leal, Gilberto; Sánchez González, Adriana; Portillo Reyes, Verónica; Reyes Ruvalcaba, David; Bojórquez Rangel, Guillermo

    2014-09-28

    Introducción: La diabetes mellitus (DM) tipo 2 es una patología común de origen multifactorial cuyas bases genéticas exactas se desconocen aún; diversos estudios sugieren que los polimorfismos de nucleótido único (SNPs) en el gen CAPN10 (Locus 2q37.3) podrían participar en su desarrollo, incluyendo el polimorfismo de inserción/ deleción SNP-19 (2R→3R). Objetivo: Determinar la relación entre el polimorfismo SNP-19 y la presencia de DM tipo 2 en una población de Ciudad Juárez. Métodos: Se seleccionaron 107 individuos: 43 diabéticos tipo 2 (casos) y 64 no diabéticos sin antecedentes heredo-familiares de DM tipo 2 en primer grado (control). Se realizó estudio antropométrico y perfil bioquímico de lípidos, lipoproteínas y glucosa sérica. Se extrajo ADN de linfocitos de sangre periférica y se amplificó mediante la técnica de reacción en cadena de la polimerasa (PCR). Se analizaron los genotipos del polimorfismo SNP-19 del gen CAPN10 por análisis electroforético en geles de agarosa. Se calcularon las frecuencias genotípicas y alélicas y se realizaron pruebas de equilibrio de Hardy-Weinberg (GenAlEx 6.4). Resultados: El análisis mediante la prueba X² identificó diferencias en los genotipos entre casos y control, con una mayor frecuencia del genotipo homocigoto 3R del SNP-19 en el grupo de casos (0.418) respecto al grupo control (0.265). El genotipo 2R/3R presentó relación con valores elevados de peso, índice de masa corporal y perímetros de cintura y cadera; pero solo en el grupo de diabéticos (P=< 0.05). Conclusión: Los resultados de esta investigación sugieren la participación del SNP-19 del gen CAPN10 en el desarrollo de DM tipo 2 en la población estudiada.

  20. [CAFFEINE INTAKE AND ITS EFFECT ON THE MAXIMAL AEROBIC SPEED CORRIDORS 800 -METER ATHLETES].

    PubMed

    Rosales Soto, Giovanni; Monsálves Álvarez, Matías; Yáñez Sepúlveda, Rodrigo; Durán Agüero, Samuel

    2015-10-01

    Objetivos: comprobar los efectos de la ingesta de cafeína (3 mg/kg-1) y la mejora del tiempo límite hasta el agotamiento de la velocidad aeróbica máxima que podría modificar los niveles de lactato en sangre en corredores de 800 metros lisos. Material y método: el estudio está basado en un diseño experimental, cruzado, aleatorio y ciego. Se evaluaron 7 sujetos (20 ± 3 años, 63 ± 6 kg y 169,1 ± 7 cm) corredores de 800 metros lisos, que debían estar compitiendo al menos durante tres años y estar entre los diez primeros lugares del ranking nacional. Realizaron una prueba de tiempo límite hasta el agotamiento en cinta rodante a la velocidad aeróbica máxima, donde ingirieron una cápsula que podía contener cafeína (3 mg/kg-1) o placebo (sucralosa). Se midió la concentración de lactato en reposo y al final de cada prueba. Resultados: la ingesta de cafeína reflejó un aumento significativo en la duración del tiempo límite en relación al placebo (376 ± 137 - 457 ± 182 s, respectivamente, p < 0,05). En cuanto al lactato sanguíneo, hay diferencia significativa entre la condición de reposo, el placebo y la ingesta de cafeína (p < 0,05). Conclusiones: la utilización de cafeína como ayuda ergogénica, en dosis de 3 mg/kg-1, incrementa significativamente (p < 0,05) el TLIM de la VAM hasta el agotamiento. Este efecto significa una mejora en el rendimiento de los corredores de 800 metros lisos. A su vez, se aprecia un aumento significativo en las concentraciones de lactato, que podrían hacer referencia al aumento en la intensidad de trabajo posterior a la ingesta de cafeína.

  1. Use of black vulture (Coragyps atratus) in complementary and alternative therapies for cancer in Colombia: A qualitative study

    PubMed Central

    2012-01-01

    ingesta de la sangre fresca y el mecanismo de acción asociado es la transferencia de defensas a quien lo consume. Conclusiones La utilización del Coragyps atratus como tratamiento para el cáncer es una terapia alternativa usada popularmente en Colombia. El uso de este animal debe estudiarse más a fondo para conocer los efectos clínicos en los pacientes con cáncer. PMID:22651097

  2. [Oxidative stress; a comparative study between normal and morbid obesity group population].

    PubMed

    De Tursi Ríspoli, Leonardo; Vázquez Tarragón, Antonio; Vázquez Prado, Antonio; Sáez Tormo, Guillermo; Mahmoud Ismail, Ali; Gumbau Puchol, Verónica

    2013-01-01

    Objetivo: Determinar el grado de Estrés Oxidativo en pacientes obesos mórbidos comparando los resultados con los de una población normal. Material y método: Hemos estudiado los metabolitos más representativos del EO, tanto en sangre (MDA, 8-oxo-dG, GSSG y la relación GSSG/GSH) como en orina (8-oxo-dG), así como el antioxidante GSH. Realizamos un análisis descriptivo de la muestra. Se realizó la prueba de Kolmogorv-Smirnov para evaluar si la distribución de los distintos metabolitos seguía un modelo de normalidad. En los casos de distribución normal, se empleó la T de Student para comparar medias, utilizando la U de Mann-Whitney para los datos no paramétricos, utilizando en los contrastes de hipótesis el nivel de significación p < 0,05. Resultados: Los pacientes fueron 28 en cada grupo, sin diferencias estadísticamente significativas en cuanto a edad y sexo. El grupo de pacientes con obesidad mórbida presentó un IMC medio de 50,1 ± 4 y de 23,9 ± 6 el grupo normopeso. Un 67,8% de los pacientes obesos mórbidos presentaron comorbilidades. No había patología asociada en el grupo control. Todos los valores de los distintos metabolitos de EO fueron más elevados en el grupo de obesos mórbidos que en el grupo control mientras que la actividad de los sistemas antioxidantes (GSH) fue menor en el grupo de obesos mórbidos. Conclusión: Los valores de los metabolitos de EO obtenidos en el grupo de obesos mórbidos confirma la presencia de EO en la obesidad, de un modo que se puede considerar patológico dadas las diferencias obtenidas en el grupo de población normal.

  3. Effects of quercetin on polychlorinated biphenyls-induced liver injury in rats.

    PubMed

    Rocha de Oliveira, Cléia; Ceolin, Juliana; Rocha de Oliveira, Renata; Gonçalves Schemitt, Elizângela; Raskopf Colares, Josieli; De Freitas Bauermann, Liliane; Hilda Costabeber, Ijone; Morgan-Martins, Maria Isabel; Mauriz, José L; Da Silva, Juliana; Reyes, Juliana Moysés; Possa Marroni, Norma

    2014-05-01

    Introducción: los bifenilospoliclonados (PCBs) son pesticidas ampliamente usados en agricultura que pueden inducir daños irreversibles particularmente en el hígado. El estrés oxidativo ha sido implicado en diversas patogénesis hepáticas, incluidas las relacionadas conPCBs. La quercetina, un flavonoide de la dieta, ha demostrado tener un potente efecto antioxidante en diversos modelos de patología hepática. Objetivo: Evaluar el estrés oxidativo hepático inducido por PCBs y la actividad antioxidante de la quercetina. Metodología: Se usaron ratas macho de raza Wistar (n = 36), divididas en cuatro grupos: control, quercetina (50 mg/kg/día), PCBs (0,4 ml/kg/día) y ratas tratadas tanto con PCBs como con quercetina. Transcurridos 25 días de tratamiento se recogieron muestras de sangre, para evaluar la integridad hepática (AST, ALT y ALP), y de tejido para cuantificar el estrés oxidativo (TBARS), actividad antioxidante (SOD, CAT, GPx), daño al DNA (ensayo de micronúcleos) y daño histológico. Resultados: la concentración de TBARS y la actividad SOD fueron significativamente mayores en los animales que recibieron PCBs que en los que recibían quercetina. La actividad de CAT y GPx se redujo con los PCBs y se incrementó al administrar quercetina. Los análisis histológicos y de micronúcleos mostraron daño hepático y al DNA respectivamente inducido por PCBs que eran revertidos con el tratamiento con quercetina. Conclusion: La contaminación con PCBs induce un incremento en la peroxidación lipídica, modificación en la actividad de enzimas antioxidantes, daño histológico y al DNA en el hígado, siendo el antioxidante quercetina es capaz de reducir dichos cambios.

  4. EFFECT OF LONG TERM INTAKE OF WHITE TEA ON ACUTE OXIDATIVE STRESS IN RATS.

    PubMed

    Espinosa, Cristóbal; González-Silvera, Daniel; Pérez-Llamas, Francisca; López-Jiménez, José Ángel; Zamora, Salvador

    2015-08-01

    Introducción: las propiedades antioxidantes del té son ampliamente conocidas, entre las que se incluyen la prevención del cáncer, diversas enfermedades neurodegenerativas y otras patologías relacionadas con el estrés oxidativo. Por otro lado, la adriamicina es un agente antitumoral que tiene la capacidad de generar estrés oxidativo in vivo. Objetivo: valorar el efecto de la ingesta de té blanco a largo plazo sobre la capacidad antioxidante plasmática y el perfil de ácidos grasos de microsomas de hígado y corazón en animales sometidos a estrés oxidativo agudo. Métodos: se dispuso de ratas a las que se les administró diferentes dosis de té blanco: 0,15 y 45 mg de extracto sólido de té/kg de peso corporal durante 12 meses. Tras este periodo de tratamiento con té blanco, todos los animales recibieron una inyección intraperitoneal de adriamicina (ADR), 10 mg/kg de peso corporal, excepto la mitad del grupo control, que recibieron una inyección de solución salina. Fueron obtenidas muestras de sangre, corazón e hígado. Se analizó la capacidad antioxidante total y se realizaron análisis de oxidación proteica y lipídica en plasma. Además, se obtuvo la fase microsomal de hígado y corazón. Resultado y discusión: se observó una fuerte oxidación lipídica en plasma y una recuperación en los animales tratados con las diferentes dosis de té. La actividad antioxidante y la oxidación proteica, aunque relevantes, solo muestran una ligera tendencia a recuperarse con el tratamiento con té. En cuanto al perfil de ácidos grasos, solamente se observan ligeras tendencias en el porcentaje de ácidos grasos saturados, monoinsaturados y poliinsaturados.

  5. GLUTATHIONE PEROXIDASE-1 PRO200LEU POLYMORPHISM (RS1050450) IS ASSOCIATED WITH MORBID OBESITY INDEPENDENTLY OF THE PRESENCE OF PREDIABETES OR DIABETES IN WOMEN FROM CENTRAL MEXICO.

    PubMed

    Hernández Guerrero, César; Hernández Chávez, Paulina; Martínez Castro, Noemí; Parra Carriedo, Alicia; García Del Rio, Sandra; Pérez Lizaur, Ana

    2015-10-01

    Introducción: la obesidad afecta a una tercera parte de la población mexicana. El estrés oxidativo (EO) participa activamente en la etiología del fenómeno. La glutatión peroxidasa-1 (GPx-1) juega un papel protector contra el EO. El SNP Pro200Leu (rs10504050) afecta a la actividad de la enzima. Objetivo: determinar la frecuencia del polimorfismo rs10504050 en mujeres con obesidad (OB) y normopeso (CG), determinar la concentración de TBARS en sangre periférica y evaluar el consumo de pro y antioxidantes. Métodos: en el estudio se incluyeron 104 mujeres con obesidad y 70 controles. El polimorfismo rs10504050 se determinó por el método PCR/RFLP. La concentración de TBARS se cuantificó mediante espectrofotometría en plasma sanguíneo. Las participantes se estratificaron y compararon por grados de obesidad y subgrupos de prediabetes y diabetes. Se emplearon las pruebas estadísticas ANOVA de Kruskal Wallis, Xi cuadrada y correlación de Pearson. Resultados: el polimorfismo rs10504050 mostró diferencias estadísticas (Xi2 = 6; p = 0,01) entre la frecuencia del grupo OB (0,61) por arrastre (Pro/Leu+Leu/Leu) y el CG (0,42), así como (Xi2 = 8; p = 0,004) entre personas con obesidad mórbida (0,74) comparadas con el CG. No hubo diferencia significativa entre las frecuencias del rs10504050 en OB con pre o diabetes, comparado con el CG, ni con personas con obesidad sin diabetes. Las concentraciones de TBARS fueron mayores en todos los grados de OB comparados con el CG. Conclusión: el polimorfismo rs10504050 se asoció con obesidad, especialmente mórbida, pero no se asoció con diabetes o prediabetes. El estrés oxidativo está presente de manera significativa en todos los grados de obesidad.

  6. Effects of a low-fat diet with antioxidant supplementation on biochemical markers of multiple sclerosis long-term care residents.

    PubMed

    Mauriz, Elba; Laliena, A; Vallejo, D; Tuñón, M J; Rodríguez-López, J M; Rodríguez-Pérez, R; García-Fernández, M C

    2013-11-01

    Introducción: Las posibilidades de tratamiento de la esclerosis múltiple (EM) se encuentran limitadas principalmente a terapias con inmumoduladores en las formas no progresivas de EM. Los estudios de intervención nutricional sugieren que la dieta puede considerarse como un tratamiento alternativo para controlar la progresión de la enfermedad. Por esta razón, las intervenciones en la dieta pueden ayudar a mejorar el bienestar y mejorar los síntomas de los pacientes con EM. Objetivos: Valorar el efecto de una dieta pobre en grasas con suplementación de antioxidantes en los marcadores bioquímicos de pacientes institucionalizados que presentan formas progresivas de EM. Métodos: Se realizó un estudio prospectivo aleatorizado controlado por placebo con 9 participantes, 5 de los cuales se asignan al grupo de intervención (dieta baja en grasas y suplementación antioxidante) y los 4 restantes al grupo placebo (dieta baja en grasas). Se evaluó el efecto de la intervención dietética que supone modificación de la dieta e introducción de antioxidantes durante 42 días mediante valoraciones de parámetros antropométricos y bioquímicos y marcadores del estrés oxidativo en sangre y orina en las etapas inicial (día 0), intermedia (día 15) y final (día 42) del tratamiento. Resultados: Se obtuvieron niveles de proteína C reactiva significativamente inferiores en el grupo de intervención con respecto al grupo placebo al final del estudio. Los marcadores de estrés oxidativo e inflamación: isoprostanos 8-iso-PGF2e interleucina IL-6 también disminuyeron en el grupo de intervención después de la intervención dietética. La actividad de la enzima catalasa aumentó de forma significativa en el grupo de intervención antes de la suplementación con antioxidantes. No se observaron diferencias significativas en otros marcadores de estrés oxidativo. Conclusiones: Los resultados obtenidos sugieren que la dieta y los suplementos dietéticos est

  7. Protein intake, nitrogen balance and nutritional status in patients with Parkinson's disease; time for a change?

    PubMed

    Zilli Canedo Silva, Maryanne; Carol Fritzen, Natali; de Oliveira, Marlon; Paes da Silva, Michel; Rasmussen Petterle, Ricardo; Teive, Hélio Afonso; de Mesquita Barros Almeida Leite, Christiane; Rabito, Estela Iraci; Madalozzo Schieferdecker, Maria Eliana; Carvalho, Mauricio

    2015-06-01

    Objetivo: evaluar ingestión proteica, balance nitrogenado y estado nutricional de pacientes con enfermedad de Parkinson (EP) clínicamente estables. Métodos: estudio transversal de pacientes con EP en los niveles 1-3 según la escala de Hoehn-Yahr e individuos sin enfermedad neurológica (controles), pareados por edad y género. Todos los participantes fueron sometidos a una entrevista de la historia nutricional, antropometría, impedancia eléctrica y registro alimentario de 3 días consecutivos, incluyendo un fin de semana. Fueron colectados sangre venosa en ayuno y orina de 24 horas para evaluación de la depuración de la creatinina, índice creatinina-altura y balance nitrogenado. Resultados: el promedio de edad en pacientes con EP fue 58,9 ± 12,8 años en comparación con 54,7 ± 12,6 años de los controles, p = 0,345. Un tercio del grupo EP tuvo síntomas de disfagia, con menor ingestión de agua y fibras, comparados a los controles. La circunferencia de la pantorrilla fue menor en grupo EP (35,5 ± 2,8 vs. 38,4 ± 3,5 cm, p = 0,012). La ingestión de nitrógeno fue significativamente menor y el balance de nitrógeno fue negativo en grupo EP (-1,8 ± 3,9 vs. 1,1 ± 4,2 controles, p = 0,064). Los antioxidantes folato y vitamina E fueron consumidos en pequeñas cantidades en ambos grupos, aunque significativamente menor en los pacientes con EP (p = 0,042 y 0,031, respectivamente). Discusión: la ingestión proteica diaria de aproximadamente 1,1 g/kg en pacientes clínicamente estables con EP puede no ser suficiente para garantizar un balance neutro de calorías-nitrógeno, así como para mantener la masa muscular. Serán necesarios mayores estudios que produzcan una imagen más completa del estado metabólico de los pacientes con Parkinson.

  8. Ethnomedicines used in Trinidad and Tobago for reproductive problems

    PubMed Central

    Lans, Cheryl

    2007-01-01

    Background Throughout history women have tried to control or enhance their fertility using herbal remedies, with various levels of societal support. Caribbean folk medicine has been influenced by European folk medicine, either through the early Spanish and French settlers or through the continuous immigration of Spanish-speaking peoples from Venezuela. Some folk uses are ancient and were documented by Galen and Pliny the Elder. Methods Thirty respondents, ten of whom were male were interviewed from September 1996 to September 2000. The respondents were obtained by snowball sampling, and were found in thirteen different sites, 12 in Trinidad (Paramin, Talparo, Sangre Grande, Mayaro, Carapichaima, Kernahan, Newlands, Todd's Road, Arima, Guayaguayare, Santa Cruz, Port of Spain and Siparia) and one in Tobago (Mason Hall). Snowball sampling was used because there was no other means of identifying respondents and to cover the entire islands. The validation of the remedies was conducted with a non-experimental method. Results Plants are used for specific problems of both genders. Clusea rosea, Urena sinuata and Catharanthus roseus are used for unspecified male problems. Richeria grandis and Parinari campestris are used for erectile dysfunction. Ageratum conyzoides, Scoparia dulcis, Cucurbita pepo, Cucurbita maxima, Gomphrena globosa and Justicia pectoralis are used for prostate problems. The following plants are used for childbirth and infertility: Mimosa pudica, Ruta graveolens, Abelmoschus moschatus, Chamaesyce hirta, Cola nitida, Ambrosia cumanenesis, Pilea microphylla, Eryngium foetidum, Aristolochia rugosa, Aristolochia trilobata, Coleus aromaticus, Laportea aestuans and Vetiveria zizanioides. The following plants are used for menstrual pain and unspecified female complaints: Achyranthes indica, Artemisia absinthium, Brownea latifolia, Eleutherine bulbosa, Hibiscus rosa-sinensis, Eupatorium macrophyllum, Justicia secunda, Parthenium hysterophorus, Wedelia trilobata

  9. RASTREO DEL CANCER COLORRECTAL CONOCIMIENTO Y ACTITUD DE LA POBLACION

    PubMed Central

    CASAL, ENRIQUE R.; VELAZQUEZ, ELIZABETH N.; MEJIA, RAUL M.; CUNEO, ALDO; PEREZ-STABLE, ELISEO J.

    2014-01-01

    Resumen El rastreo de cáncer colorrectal (CCR) cuenta con fuertes evidencias en su favor. Datos preliminares indican que a pesar de ello no se lleva a cabo con la frecuencia adecuada. Se intenta aquí determinar, dentro de un Sistema de Salud que cuenta con los recursos necesarios, los elementos que facilitan o generan barreras para concretar esta práctica preventiva, cuántos individuos lo ponen en práctica y qué predice esta conducta. Se realizó una encuesta telefónica a los afiliados de una Obra Social de empleados de la Universidad de Buenos Aires, de los que 132 completaron el cuestionario (tasa de respuesta 70%). Los elementos considerados facilitadores del rastreo obtuvieron respuestas afirmativas en el 64 a 97%, mientras que los que definían barreras un 11 a 27%. En este último grupo, una categoría diferenciada la constituía el miedo a los efectos adversos: 39%, y el sentimiento de vergüenza relacionado con los procedimientos: 30%. Un 33% de los encuestados tenían hecho un método de rastreo, mayoritariamente de sangre oculta (27), sigmoideoscopía (11) y colonoscopía (20). Una mayoría afirmó que “se haría el procedimiento si el médico se lo recomendara” (95%), o “no se lo haría excepto que su médico se lo aconseje” (87%). Contestar afirmativamente que “los médicos hacen lo mejor para los pacientes” se asoció con haberse hecho un método de rastreo de CCR, OR 1.55 (IC 95%: 1.02-2.37) p: 0.04. El grupo de individuos estudiado parece bien predispuesto para el rastreo del CCR, la recomendación médica sería aquí un determinante prominente para ponerlo en práctica. PMID:19414294

  10. [Subclinical atheroesclerosis and metabolic syndrome in children].

    PubMed

    Arnaiz, Pilar; Barja, Salesa; Villarroel, Luis; Domínguez, Angélica; Godoy, Iván; Castillo, Oscar; Farías, Marcelo; Mardones, Francisco

    2013-01-01

    Introducción: El síndrome metabólico (SM) en niños se ha vinculado al desarrollo de ateroesclerosis subclínica, estimada por el grosor intimo-medial carotideo (CIMT). Objetivos: Estudiar la asociación del CIMT con los componentes del SM, la resistencia insulínica (RI) y el estado nutricional en escolares, además de explorar puntos de corte asociados a riesgo. Métodos: Estudio transversal de 447 niños asistentes a escuelas públicas de Santiago, Chile (2009-2011), seleccionados por presentar uno o más componentes del SM y RI. Se realizó antropometría y toma estandarizada de presión de arteria braquial, además de muestras de sangre para determinar lípidos glicemia e insulinemia. Se midió el CIMT por ultrasonografía de alta resolución. Se utilizó correlación de Pearson, t de Student, chi cuadrado y regresión logística. Resultados: Edad 11,5 ± 1,0 años (rango 10-14); 59% mujeres; 93% púberes; 72% con exceso de peso; 24% con SM y 15% con RI. Los promedios de los componentes del SM en los niños con CIMT ≥?percentil 75 vs < percentil 75 tuvieron diferencias para presión arterial sistólica o diastólica ≥?percentil 90 (PA) y colesterol unido a lipoproteínas de alta densidad =?40 mg/dL (CHDL). En la regresión logística para CIMT ≥?percentil 75 fueron seleccionadas PA y CHDL. En la regresión logística para CIMT ≥?percentil 90 no hubo variables seleccionadas. Conclusiones: En este grupo de niños los niveles de PA y CHDL se asocian con CIMT ≥?percentil 75. No se encontró asociación con estado nutricional y RI posiblemente por ser una muestra seleccionada.

  11. [ACCURACY PARAMETERS AS INDICATORS OF ANTHROPOMETRIC ADIPOSITY VISCERAL SCHEDULED FOR TWO-DIMENSIONAL EQUATION].

    PubMed

    Lira Santos, Andréia; Araújo Tavares de Sá, Cristiane Maria; Calado Brito, Daniel; Lourenço Batista, Camila; Kétteryn Maior Evangelista da Costa, Meury; Araújo Gomes de Lima, Kamilla Brianne; Magalhães Souza, Jaqueline; Tenório Ramos, Irya Laryssa

    2015-11-01

    Introducción: los indicadores antropométricos son fáciles de aplicar y pueden ayudar en la identificación de la acumulación de grasa visceral, lo que favorece la aparición de eventos cardiovasculares, así como, el aumento de la morbilidad y mortalidad por enfermedades crónicas. Objetivo: evaluar la exactitud de los indicadores antropométricos de distribución de la grasa abdominal para determinar la adiposidad visceral. Sujetos/Métodos: estudio transversal realizado con pacientes ambulatorios, de ambos sexos, mayores de 20 años. Fueron evaluados: circunferencia de la cintura (CC); relación cintura-cadera (WHR); cintura-altura (CER); índice Taper (CI); diámetro abdominal sagital (DAS); (DC) de diámetro coronal; índice de masa corporal (IMC); porcentaje de grasa corporal (% GC); adiposidad visceral (AV/AS) predicha por la fórmula; glucosa en sangre en ayunas; colesterol total (TC); lipoproteína de baja densidad (LDL); lipoproteína de alta densidad (HDL); lipoproteínas de muy baja densidad (VLDL) y triglicéridos (TG). Resultados: se evaluaron 129 pacientes, edad media 51, 06 + 14,02 años y una mayor prevalencia de adultos (72,9%) y mujeres (75,2%). CC 102,9 (+ 10,82), HF 2,08 (± 0,13) y AV/AS 1,03 (+ 0,16), mostraron valores altos con significación estadística entre los hombres, p < 0,001. Lo mismo ocurrió con la CT (+ 46,4 212,41), HDL (50,15 + 13,24) y LDL (135,62 + 40,16) entre las mujeres, p < 0,05. DC, RCE, DAS y DC mostraron una correlación inversa y significativa con la AV/AS: r = -0,364; -0.457; -0.403; -0.296; -0.475, respectivamente, p < 0,001. Sin embargo, que mejor explicó la varianza de la obesidad visceral fueron el DC (R² = 0,77), CQ (R² = 0,64) y RCE (R² = 0,59). Discusión/Conclusión: la DC y el CER fueron los mejores predictores para las mediciones antropométricas de la obesidad visceral.

  12. Cowpea protein reduces LDL-cholesterol and apolipoprotein B concentrations, but does not improve biomarkers of inflammation or endothelial dysfunction in adults with moderate hypercholesterolemia.

    PubMed

    Frota, Karoline de Macedo Gonçalves; dos Santos Filho, Raul Dias; Ribeiro, Valdenir Queiroz; Arêas, José Alfredo Gomes

    2015-04-01

    Introducción: Los riesgos de las enfermedades cardiovasculares, la principal causa de muerte en el mundo, pueden ser reducidos con la dieta. Proteína caupí en hámsters redujo el colesterol total, LDL-colesterol, así como la esteatosis hepática de manera significativa. Objetivo: Este estudio de prueba de concepto fue verificar si el consumo de proteína de frijol mejora el perfil de lípidos y actúa sobre los biomarcadores de inflamación y disfunción endotelial en pacientes con hipercolesterolemia moderada. Métodos: En un diseño aleatorio doble ciego cruzado, 38 sujetos con hipercolesterolemia (colesterol-LDL = 182,5 ± 2,7 mg/dL) consumieron 25 g / día de aislado de proteína de frijol o 25 g / día de caseína (grupo control) durante seis semanas cada uno, y un intervalo de lavado de cuatro semanas Se recogieron muestras de sangre en ayunas al comienzo y al final de cada período de dieta. Los lípidos (colesterol total, LDL-colesterol, triglicéridos, HDL-colesterol) se determinaron por métodos enzimáticos, apolipoproteínas (apoA-I y apoB) por inmunoensayos normalizados, biomarcadores de inflamación (proteína C reactiva) por turbidimetría y los biomarcadores de disfunción endotelial (molecule-1 de adhesión intercelular y de molécula-1 de adhesión celular vascular) por técnicas de ensayo de inmunoabsorción ligados a enzimas. Resultados y discusión: El consumo de proteínas caupí redujo significativamente el colesterol total (12%), el colesterol LDL (18,9%), colesterol no HDL (16%), apoB (14%), y aumentó el colesterol HDL (2,7%). No se observaron diferencias significativas relacionadas con el grupo de tratamiento para cualquiera de los biomarcadores inflamatorios y de disfunción endotelial. Conclusión: Los presentes hallazgos demostraron el efecto favorable del consumo de proteína caupí en lípidos séricos pro-aterogénicas y apoB en sujetos con hipercolesterolemia moderada, de manera similar a lo observado en un trabajo previo con

  13. Iron status and dietary intakes of iron in normal-weight and obese young Mexican women.

    PubMed

    Tijerina-Sáenz, Alexandra; Martínez-Garza, Nancy E; Ramírez-López, Erik; Solís-Pérez, Elizabeth; Martínez-Báez, Adbel Z

    2015-06-01

    Introducción: la obesidad se ha reportado como predictor de la deficiencia de hierro. En México, el 45,5% de las mujeres mayores de 20 años tienen obesidad, y la prevalencia de anemia es de 10,2% en mujeres de 20 a 29 años. Objetivo: investigar la relación entre índice de masa corporal (IMC), porcentaje de grasa (%GC), ingesta dietética y reservas de hierro en mujeres jóvenes sanas con normopeso y obesidad. Métodos: ochenta y seis mujeres [normopeso (n = 46) y obesidad (n = 40)] completaron el estudio. La ingesta fue evaluada por un diario de registro de 8 días. La antropometría y obtención de sangre (hemoglobina, hematocrito, ferritina y transferrina) se consiguieron en la fase lútea del ciclo menstrual; se reportaron las características de la menstruación. Las reservas de hierro se determinaron según etapas de depleción. Pruebas de T y Mann-Whitney U se usaron para comparar variables entre grupos. La correlación de Pearson se usó para determinar relaciones entre variables. La razón de momios se utilizó para medir la asociación de IMC, %GC e ingesta dietética con las reservas de hierro. Resultados: los marcadores de hierro fueron similares entre grupos. Se encontró una relación positiva entre %GC y ferritina (r = 0,222; p = 0,032). La similitud en ingesta y periodos menstruales puede ser la razón de que existan reservas de hierro similares. El IMC, %GC e ingesta dietética no contribuyeron independientemente a las etapas de depleción de hierro. Conclusión: se sugiere guía dietética para esta población con el fin de evitar complicaciones por deficiencia de hierro.

  14. Patterns of LGM precipitation in the U.S. Rocky Mountains: results from regional application of a glacier mass/energy balance and flow model

    NASA Astrophysics Data System (ADS)

    Leonard, E. M.; Laabs, B. J.; Refsnider, K. A.; Plummer, M. A.; Jacobsen, R. E.; Wollenberg, J. A.

    2010-12-01

    Global climate model (GCM) simulations of the last glacial maximum (LGM) in the western United States predict changes in atmospheric circulation and storm tracks that would have resulted in significantly less-than-modern precipitation in the Northwest and northern Rockies, and significantly more-than-modern precipitation in the Southwest and southern Rockies. Model simulations also suggest that late Pleistocene pluvial lakes in the intermontane West may have modified local moisture regimes in areas immediately downwind. In this study, we present results of the application of a coupled energy/mass balance and glacier-flow model (Plummer and Phillips, 2003) to reconstructed paleoglaciers in Rocky Mountains of Utah, New Mexico, Colorado, and Wyoming to assess the changes from modern climate that would have been necessary to sustain each glacier in mass-balance equilibrium at its LGM extent. Results demonstrate that strong west-to-east and north-to-south gradients in LGM precipitation, relative to present, would be required if a uniform LGM temperature depression with respect to modern is assumed across the region. At an assumed 7oC temperature depression, approximately modern precipitation would have been necessary to support LGM glaciation in the Colorado Front Range, significantly less than modern precipitation to support glaciation in the Teton Range, and almost twice modern precipitation to sustain glaciers in the Wasatch and Uinta ranges of Utah and the New Mexico Sangre de Cristo Range. The observed west-to-east (Utah-to-Colorado) LGM moisture gradient is consistent with precipitation enhancement from pluvial Lake Bonneville, decreasing with distance downwind from the lake. The north-to-south (Wyoming-to-New Mexico) LGM moisture gradient is consistent with a southward LGM displacement of the mean winter storm track associated with the winter position of the Pacific Jet Stream across the western U.S. Our analysis of paleoglacier extents in the Rocky Mountain

  15. [COMPARISON OF FREE CARNITINE LEVELS WITH NUTRITIONAL STATUS IN INFANTILE NEPHROPATHYC CISTINOSIS PATIENTS].

    PubMed

    Guillén-López, Sara; Ibarra-González, Isabel; Belmont Martínez, Leticia; Juárez-Cruz, Merit Valeria; Vela-Amieva, Marcela

    2015-12-01

    Introducción: la cistinosis nefropática infantil (CNI) es una enfermedad genética debida a un defecto del transporte de la cistina, con la subsecuente acumulación de este aminoácido predominantemente en el riñón. Existen pocos estudios sobre la evaluación del estado nutricional en pacientes con esta patología, pero se sabe que tienen una excreción de carnitina urinaria aumentada, lo que puede dar como resultado una deficiencia plasmática y muscular de este compuesto; sin embargo, la suplementación de carnitina en CNI es controversial. Objetivo: comparar la concentración sanguínea de carnitina libre (C0) con el estado nutricional de una cohorte de pacientes con CNI. Material y métodos: evaluación antropométrica mediante la medición de peso, talla, perímetro braquial (PB) y pliegue cutáneo tricipital (PCT). La C0 se cuantificó mediante espectrometría de masas en tándem en muestras de sangre en ayuno. Resultados: se analizaron 10 pacientes con CNI, 5 con y 5 sin trasplante renal. De acuerdo con el IMC, 3/10 presentaron desnutrición. La reserva de masa magra se encontró baja en 8/10 pacientes (3 no trasplantados y todos los trasplantados). El PB mostró correlación con las concentraciones sanguíneas de C0 (r2 = 0,353); Los pacientes no trasplantados tuvieron niveles de C0 significativamente más bajos que los trasplantados (Chi2 = 0,0027). Conclusión: en esta población de pacientes con CNI se encontró un 70% de sujetos con C0 baja, que se correlaciona con la masa magra disminuida. Es recomendable hacer una evaluación nutricional de rutina que incluya los tres parámetros antropométricos como parte del seguimiento médico-nutricional integral de estos pacientes.

  16. Climatic controls on steady state erosion using the relationship between channel steepness and cosmogenic 10Be-derived catchment averaged erosion rates

    NASA Astrophysics Data System (ADS)

    Rossi, M. W.; Whipple, K. X.; DiBiase, R. A.; Heimsath, A. M.

    2011-12-01

    the San Jacinto Mountains, CA (P = ~0.25 m/yr); Sierra San Pedro Martir, MX (P = ~0.25 m/yr); Sangre de Cristo Mountains, NM (P = ~1 m/yr); North Sierra Nevada, CA (P = ~2 m/yr); Sierra Nombre de Dios, HN (P = ~3 m/yr). These landscapes exhibit large differences in mean annual precipitation, mean annual temperature, mean daily runoff, and runoff variability. Using long time-series hydrological and meteorological data, we assess the capabilities and limitations of stochastic-threshold incision models for predicting the relationship between channel steepness and erosion rate. Further, we document quantifiable changes in erosional efficiency for differing climate conditions that can be used as a baseline for interpreting the effects of climate change in steep mountain catchments.

  17. Effect of probiotics on human blood urea levels in patients with chronic renal failure.

    PubMed

    Miranda Alatriste, Paola Vanessa; Urbina Arronte, Rocío; Gómez Espinosa, Cristóbal Obet; Espinosa Cuevas, María de los Ángeles

    2014-03-01

    Introducción: Los pacientes con enfermedad renal crónica (ERC) muestran un aumento a nivel intestinal de bacterias aeróbicas que generan toxinas urémicas y disminución de bacterias anaeróbicas como bifidobacterias y lactobacilos. Estas últimas se pueden utilizar como probióticos. El probiótico con mayor disponibilidad en México, es el lactobacillus casei shirota (LcS), actualmente no se conoce que dosis de LcS puede generar un beneficio para el paciente con ERC. Objetivo: Determinar el efecto de 2 dosis diferentes de LcS para disminuir al menos 10% las concentraciones de urea en pacientes con ERC estadios KDOQI 3 y 4. Métodos: Ensayo clínico controlado con asignación aleatoria en el cual se incluyeron pacientes ambulatorios con ERC del Instituto Nacional de Ciencias Médica y Nutrición Salvador Zubiran. Se asignó a los pacientes a uno de los dos grupos, grupo A: 8 x 109 unidades formadoras de colonias (UFC) y grupo B: 16 x 109 UFC. El seguimiento fue de ocho semanas, obteniendose una muestra de sangre basal y otra final para conocer concentraciones de urea y creatinina. Ambos grupos consumieron una dieta de 30 kcal/kg/peso y 0,8 g/kg/peso de proteína, se realizó un diario de alimentación para evaluar el cumplimiento de la dieta y del tratamiento del LcS. Resultados: Se evaluaron 30 pacientes. Al analizar el porcentaje de cambio entre las diferentes dosis se encontró una disminución mayor al 10% en urea sanguínea en pacientes con la dosis de 16 x 109 con respecto a su medición basal. Conclusión: Existe una disminución > 10% de la concentración sérica de urea con el LcS en pacientes con ERC 3 y 4.

  18. Trinidad's mismatched expectations. Planning and development review.

    PubMed

    Conway, D

    1984-11-01

    In 1974 petrodollars helped to boost living standards for many of the population of the Republic of Trinidad and Tobago. Yet, a failure to address the consequences of uncontrolled urbanization, especially in and around the capital, Port of Spain, threatens to undermine further improvements in the quality of Trinidadian life. Trinidad's urbanization has been associated with upward social mobility and a burgeoning middle class, such that social aspirations and spatial mobility tend to coincide. Thus, internal migration has involved a heterogeneous mixture of classes with the common denominator being a desire to improve one's standard of living. For most this means residence in or proximity to Port of Spain, the country's commercial, administrative, and cultural hub. Migration into and within Port of Spain and northwest corridors of West and East St. George County has contributed to several tricky problems, overwhelming regional planning efforts, inflating the costs of houses and land, and accelerating social alienation among urban Trinidadians. Problems could have been eased if government planning had given adequate recognition to spatial variations in societal organization, regional economic structures, and resource distribution. Trinidad changed markedly in the years 1974-81. New wealth has brought its own problems and old problems have worsened for lack of attention. The idea of decentralized growth poles at Sangre Grande, Point Fortin, La Brea, and Guayaguayare-Galeota now seems impossible to realize. The Capital region has for 10 years been absorbing a larger share of the population, now roughly half the total. It generates virtually all the island's employment opportunities and attracts the lion's share of private sector investment. Overcrowding in residences, unsanitary drainage, shortages of potable water, traffic congestion, and air pollution all have reduced the quality of life compared to 10 years ago. From 1974 onward the issue of economic development no

  19. DETERMINATION OF CHOLESTEROL IN HUMAN MILK: AN ALTERNATIVE TO CHROMATOGRAPHIC METHODS.

    PubMed

    Álvarez-Sala, Andrea; Garcia-Llatas, Guadalupe; Barberá, Reyes; Lagarda, María Jesús

    2015-10-01

    Introducción: la leche humana (HM) se considera el modo óptimo de alimentación en lactantes sanos. El colesterol (CHOL) es importante para el correcto desarrollo del sistema nervioso y la síntesis de hormonas y vitaminas en el crecimiento del lactante. Se ha constatado que la lactancia materna y la ingesta dietética de CHOL durante la infancia influye en los niveles de lípidos en sangre, así como en el riesgo de enfermedad cardiovascular en la edad adulta. La técnica más utilizada para determinar el CHOL en HM es la cromatografía de gases. Los métodos cromatográficos son específicos para la determinación del CHOL y otros esteroles presentes en la HM, pero el elevado tiempo consumido, los costes y la necesidad de una instrumentación específica hacen que no sea accesible para cualquier laboratorio. Objetivo: el presente estudio describe la optimización y validación de un método enzimático-espectrofotométrico para la determinación del CHOL en HM madura. Métodos: la determinación del CHOL requiere una extracción lipídica con cloroformo:metanol, saponificación en caliente y extracción del insaponificable con dietil éter. El CHOL fue determinado por un método enzimático en el que la concentración de lutidina formada es estequiométrica a la cantidad de CHOL, y se mide a 405 nm. Resultados: la cantidad de grasa (mg/mL) (27,5 ± 1,3) y de CHOL (0,113 ± 0,004) en la HM analizada se halla en el intervalo indicado por otros autores. Se evalúan parámetros analíticos del método propuesto: la precisión (expresada como desviación estándar relativa en %) fue de 3,5 y 6,7 para intra- e interdía, respectivamente. La exactitud, estimada mediante ensayos de recuperación, fue de 110 ± 1,6%. Conclusión: el método enzimático-espectrofotométrico validado para determinar el CHOL en HM constituye una alternativa para el análisis rápido y sencillo de CHOL empleando equipos accesibles para cualquier laboratorio.

  20. [Review of enteral drugs administration for viral diseases: HIV, HBV and HCV].

    PubMed

    Arenas Villafranca, José Javier; Nieto Guindo, Miriam; Romero Domínguez, Rocío; Tortajada Goitia, Begoña; Faus Felipe, Vicente

    2013-01-01

    Introducción: Las características demográficas de los pacientes infectados por VIH han cambiado en los últimos años y las co-infecciones por virus de la hepatitis B y C son muy comunes en estos pacientes. Debido al aumento de supervivencia, a menudo estos pacientes presentan patologías o tienen que ser sometidos a intervenciones quirúrgicas que imposibilitan o dificultan la ingesta siendo necesaria la utilización de la vía enteral para la administración de fármacos. De entre los factores que influyen en el fracaso terapéutico destacan falta de adherencia, la falta de concentraciones adecuadas en sangre por malabsorción o interacciones y los errores de dosificación. Por ello se pretende elaborar una guía con recomendaciones de administración por vía enteral de los medicamentos antivirales. Material y métodos: Se revisaron las fichas técnicas de los medicamentos utilizados en VIH, VHB o VHC. Se llevó a cabo una búsqueda en las bases de datos Pubmed® y Micromedex®, se contactó con los fabricantes y se revisó otra literatura al respecto. Resultados: Los resultados se detallan en la Tabla 1. Discusión: A veces, la mera suspensión del comprimido triturado en agua no basta y esta práctica hace que muchos fármacos vean alterada su biodisponibilidad con la consiguiente modificación del efecto terapéutico. Actualmente no existe suficiente evidencia que apoye las prácticas de triturado y suspensión de los fármacos expuestos en este estudio, y consideramos que deberían llevarse a cabo más estudios para determinar la biodisponibilidad de formulaciones diferentes a las convencionales, especialmente de los medicamentos de reciente comercialización.

  1. [BEHAVIOR OF HEMOGLOBIN CONCENTRATION, HEMATOCRIT AND OXYGEN SATURATION IN COLOMBIAN UNIVERSITY POPULATION AT DIFFERENT ALTITUDES].

    PubMed

    Trompetero González, Andrea Catalina; Cristancho Mejía, Edgar; Benavides Pinzón, William Fernando; Serrato Roa, Mauricio; Landinez Macias, María Paula; Rojas, Joel

    2015-11-01

    Introducción: el desarrollo de la presente investigación se basa en el creciente interés por comprender las adaptaciones a la hipoxia crónica, principalmente en el rango altitudinal denominado de alturas intermedias (1.500- 3.000 m.s.n.m), con la necesidad de establecer parámetros de normalidad en las variables [Hb], Hct y SO2 con fines diagnósticos y de caracterización de la población. Objetivos: analizar el comportamiento de la [Hb], el Hct y la SaO2 a diferentes alturas intermedias (970 m.s.n.m, 1.520 m.s.n.m, 1.728 m.s.n.m, 1.923 m.s.n.m, 2.180 m.s.n.m y 2.600 m.s.n.m) con el fin de aportar conocimiento sobre la fisiología de la altura y al campo clínico para apoyar el diagnóstico de anemia. Métodos: sujetos clínicamente sanos, con nivel bajo de actividad física y reporte de consumo de alimentos con contenido de hierro. Total de 264 participantes de ambos géneros entre 18 y 30 años. Las muestras se obtuvieron de sangre de la vena antecubital y del lóbulo de la oreja y fueron analizadas en un radiómetro. Se realizó un análisis estadístico no paramétrico. Resultados: con el incremento de la altitud los valores de [Hb] y Hct se incrementaron, mientras la SO2 descendió. Los hombres presentaron valores más altos que las mujeres en [Hb] y Hct, relacionado con valores más bajo de SO2 que las mujeres. Discusión: no se evidenció un umbral de las variables, quizás por la pequeña distancia entre las alturas. Los valores reportados fueron similares pero no iguales a otros estudios, lo que podría deberse a la diversidad genética entre poblaciones. Conclusiones: este estudio permite obtener los primeros valores de caracterización de la población estudiada. Todas las alturas estuvieron por encima del punto de corte para el diagnóstico de anemia ([Hb] 12 g/dl).

  2. The intake of yam (Dioscorea bulbifera Linn) attenuated the hyperglycemia and the bone fragility in female diabetic rats.

    PubMed

    Rêgo, Thaís de Salgado; Ash, Louise da Silva; Pessoa, Letícia; Feijó, Márcia Barreto da Silva; Leite, Juliana; dos Santos, Aline de Sousa; da Costa, Carlos Alberto Soares; Boaventura, Gilson Teles

    2014-02-01

    Introducción: Los pacientes diabéticos tienen un mayor riesgo de fracturas osteoporóticas. Los alimentos, como el ñame, para oponerse a la hiperglucemia, se ha utilizado para el tratamiento de la diabetes. Objetivos: El objetivo era evaluar el papel de ñame brasileño (Dioscorea bulbifera) sobre la glucemia y el hueso parámetros de ratas diabéticas hembra. Métodos: Ratas Wistar hembra con 3 meses de edad fueron asignados en tres grupos. El grupo de control (C, n = 6), tratados con dieta normal de la grasa. Las ratas diabéticas tratadas con dieta alta en grasas y sin (DM, n = 8) y con (DMY, n = 8) harina de ñame liofilizado. Después se cuantificaron 5 semanas del experimento, la glucosa y la insulina en suero, la masa páncreas, el número y el área de islotes del páncreas. Y los parámetros de fémur fueron analizados por absorciometría de rayos X de energía dual (DXA) y la tomografía computarizada (CT). Resultados: Las diferencias se consideraron significativas si P < 0,05. Grupos diabéticos mostraron menor (P < 0,05): el fémur y la masa páncreas, el área de los islotes pancreáticos y la insulina. Sin embargo, DMY mostró inferior (-10%, P < 0,05) concentraciones de glucosa al grupo DM. Fémur, por DXA, mostró menor densidad mineral ósea, el contenido y el área en el grupo de DM. Mientras que el grupo DMY mostró mayor (27%, P < 0,05) radiodensidad de la cabeza femoral en comparación con el grupo de DM. Discusión: Suplemento de harina de ñame brasileña no fijó un defecto, pero alivia las consecuencias de la enfermedad diabética experimental. Se mostró resultados para controlar el aumento de los niveles de glucosa en sangre en ratas diabéticas, lo que sugiere la protección en agentes oxidantes y posponer daño en el hueso. Conclusión: Teniendo en cuenta todos los resultados de este estudio, nuestros resultados sugieren que la harina de ñame actúa de producir beneficios en la diabetes experimental.

  3. [Risk management of cardiovascular disease through milk enriched with sterols in a young-adult population; randomized controlled clinical trial].

    PubMed

    San Mauro Martín, Ismael; Collado Yurrita, Luis; Ciudad Cabañas, María José; Cuadrado Cenzual, María Ángeles; Hernández Cabria, Marta; Calle Purón, María Elisa

    2014-10-01

    Introducción: La hipercolesterolemia es uno de los factores de riesgo relevantes en la enfermedad cardiovascular, siendo el uso de esteroles vegetales una de las estrategias con mayor evidencia. Objetivos: Determinar la eficacia de una leche enriquecida en fitoesteroles para la disminución de marcadores de enfermedad cardiovascular en población joven adulta. Métodos: Ensayo clínico, controlado, aletorizado, doble ciego y cruzado. Los esteroles (2,24 g diarios) fueron ingeridos a través de una leche comercial, administrada en dos fases de 3 semanas respectivamente y separadas por un periodo de lavado de 2 semanas, para aquellos sujetos durante la fase de “leche de estudio”, y la misma cantidad de leche desnatada, sin esteroles, para el placebo. Al inicio y al final de cada fase se realizaron extracciones de sangre. Se recopilaron datos antropométricos, hábitos de salud y marcadores analíticos sanguíneos: perfil lipídico, hematológico, inflamación, etc. Resultados: Diecinueve personas culminaron el estudio de con una edad media de 34,68 años (±6,91). La diferencia entre los marcadores basales y finales para el colesterol- LDL, el Colesterol total y Triglicéridos fueron de 19,47 (±29,10) mg/dl, 24,47 (±30,68) mg/dl, 14,36 (±44,16) mg/dl, respectivamente. Sin cambios considerables en las fracciones de colesterol-HDL. Existen diferencias significativas, entre el placebo y la leche con esteroles para colesterol-LDL (p=0,009) y Colesterol total (p=0,003). Conclusiones: Los esteroles vegetales suministrados en un alimento de consumo habitual, como la leche, pueden ser una estrategia terapéutica no farmacológica de la hipoercolesterolemia y, por ello, una herramienta en la prevención del riesgo cardiovascular a nivel global.

  4. [Latex sensitization prevalence through prick test in patients with genitourinary malformations and more than 3 surgeries].

    PubMed

    Macías-Robles, Ana Paola; Morán-Mendoza, Ana Rocío

    2016-01-01

    Antecedentes: la alergia al látex tiene alta prevalencia en grupos de riesgo conocidos, especialmente en pacientes con espina bífida, malformaciones urinarias y ortopédicas con múltiples cirugías. En México no se cuenta con suficientes estudios que reporten la prevalencia y factores de riesgo asociados. Objetivo: determinar la prevalencia de sensibilización al látex mediante prueba de prick con extracto de látex en pacientes con malformaciones genitourinarias y más de tres cirugías en la Unidad Médica de Alta Especialidad de Pediatría del Centro Médico Nacional de Occidente, así como los factores asociados. Material y método: Se realizó un estudio transversal analítico y descriptivo, que incluyó hombres y mujeres de 1 a 16 años, con malformaciones genitourinarias y más de tres cirugías. Se aplicó una encuesta para conocer los factores de riesgo asociados y se realizó prueba cutánea por punción con extracto de látex, con control positivo y negativo. Se midieron niveles séricos de IgE total y eosinófilos en sangre periférica. Resultados: la prevalencia encontrada fue de 30.7% y los factores de riesgo asociados: atopia personal (p=0.047), antecedente de reacción previa con productos con látex (p=0.003), específicamente con globos (p=0.000) y guantes (p=0.002). No hubo asociación entre el número de cirugías e intervenciones quirúrgicas a edades tempranas, tampoco con concentraciones elevadas de IgE sérica total. Tuvieron reacción cruzada a frutas-látex 25% de los pacientes, los alimentos asociados fueron: aguacate, papaya, fresa y kiwi. Conclusión: la prevalencia de sensibilización al látex es alta en los grupos de riesgo, sobre todo con antecedente de atopia, por lo que es importante que el personal de salud identifique a estos pacientes a fin de implementar oportunamente las medidas de prevención primaria y secundaria; evitar efectos severos potencialmente mortales, como la anafilaxia, para disminuir la morbilidad y la

  5. [In Process Citation].

    PubMed

    Martín Álvarez, Estefanía; Jiménez Cabanillas, María Victoria; Peña Caballero, Manuela; Serrano López, Laura; Kajarabille, Naroa; Díaz Castro, Javier; Ochoa Herrera, Julio José; Maldonado Lozano, José

    2016-03-25

    Introducción: el recién nacido prematuro de muy bajo peso (RNMBP) es inmunológicamente inmaduro y además presenta una alteración de las barreras naturales de defensa. Objetivo: evaluar los efectos que pueda tener la administración de calostro orofaríngeo, administrado durante los primeros 15 días posnatales, sobre los niveles de inmunoglobulina A (IgA) sérica en recién nacidos prematuros de muy bajo peso durante el primer mes de vida. Material y métodos: se desarrolló un estudio de intervención no aleatorizado con grupo control, en el que se incluyeron 38 recién nacidos con ≤ 32 + 6 semanas de gestación y/o menores de 1.500 g de peso. Los sujetos recibieron 0,2 ml de calostro de su madre cada 4 h, iniciándose el procedimiento en las primeras 24 h de vida hasta el 15.o día postnatal. Se midieron los niveles de IgA en la sangre al nacimiento, 3. er , 15.o y 30.o días de vida. Se registraron datos perinatales al nacimiento y durante el periodo de seguimiento. Resultados: IgA sérica aumentó de forma estadísticamente significativa en el grupo de intervención (M1 15,84 μg/ml, M2 20,07 μg/ml, M3 23,65 μg/ml, M4 30,34 μg/ml, p 0,001) y en el grupo control (M1 12,48 μg/ml, M2 16,48 μg/ml, p 0,018; M3 19,41 μg/ml, M4 22,48 μg/ml, p 0,001). Al mes de vida, los niveles de IgA sérica fueron significativamente mayores en el grupo de intervención que en el grupo control (p 0,026). Conclusiones: este estudio sugiere que la administración de calostro orofarínge.

  6. Addition of dietary fiber sources to shakes reduces postprandial glycemia and alters food intake.

    PubMed

    Galvão Cândido, Flávia; Silva Ton, Winder Tadeu; Gonçalves Alfenas, Rita de Cássia

    2014-09-15

    Introducción: Obesidad y diabetes de tipo 2 pueden ser controlados por alimentos capaces de modular la ingesta de alimentos y la glucemia. Objetivos: Se investigó si la adición de alimentos fuentes de fibra o fasolamina a batidos puede controlar la ingesta de alimentos y reducir la glucemia posprandial. Métodos: Estudio aleatorizado, simple ciego, de diseño cruzado (ingesta de alimentos:n=22; glucemia:n=10). Cinco batidos con cantidades similares de macronutrientes (C - control batido, SA - salvado de avena batido, L - linaza batido, FB - extracto de frijol blanco batido y PI - harina de plátano no maduro batido) fueron consumidos en cinco días no consecutivos. Las participantes registraron la ingesta de alimentos en las 24 horas subsiguientes. La glucosa en sangre se midió a 0 (inmediatamente antes), 15, 30, 45, 60, 90 y 120 minutos después de la ingestión de cada batido y se calcularon las áreas incrementales bajo las curvas (AIBC). Resultados: En comparación a C, hubo un aumento significativo en la ingesta de fibra después de que el consumo de SA(+17,9g), SL(+19,1g), y PI(+12,6g), y en la grasa después del consumo de SA(+25,4g). Se encontró una reducción no significativa de la ingesta diaria de energía en L (1524kJ, P=0,10) en comparación con C. Hubo una reducción del 43% en el AIBC (P=0,03) en respuesta al consumo PI. Conclusiones: Harina de plátano no maduro reduce la respuesta glucémica posprandial de batidos casi a la mitad. El efecto de salvado de avena y linaza en la ingesta de alimentos requiere mayor investigación en estudios a largo plazo.

  7. [IN VIVO EFFECT OF RED WINE UNDILUTED, DILUTED (75%) AND ALCOHOL-FREE ON THE GENOTOXIC DAMAGE INDUCED BY POTENTIAL CARCINOGENIC METALS: CHROMIUM [VI

    PubMed

    García Rodríguez, María del Carmen; Mateos Nava, Rodrigo Aníbal; Altamirano Lozano, Mario

    2015-10-01

    Introducción: la carcinogénesis puede ser iniciada y promovida por el daño oxidativo al ADN. Los compuestos de cromo (Cr) [VI] generan estrés oxidativo (EOx) y son reconocidos como cancerígenos en humanos. En este sentido, se plantea que bebidas que presentan un alto potencial antioxidante, como el vino tinto, pudieran tener efectos protectores o moduladores del daño oxidativo al ADN. Objetivo: estudiar los efectos de la administración in vivo de vino tinto sin diluir, diluido (75%) y sin alcohol, sobre el daño genotóxico inducido por metales cancerígenos (Cr [VI]), mediante la evaluación de micronúcleos (MN) en eritrocitos policromáticos (EPC) de ratones (CD-1). Material y método: se conformaron aleatoriamente los siguientes grupos: (i) testigo, (ii) vino tinto sin diluir, diluido o sin alcohol (libre acceso), (iii) CrO3 (20 mg/kg por vía intraperitoneal) y (iv) vino tinto-CrO3. Las evaluaciones se realizaron en muestras de sangre obtenidas de la vena caudal, en las que se identificaron los MN en EPC antes, durante y después de los tratamientos. Resultados y discusión: el vino tinto (diluido y sin alcohol) fue capaz de disminuir los promedios de MN inducidos por el CrO3, lo que muestra su capacidad para modular in vivo el daño oxidativo al ADN causado por cancerígenos inductores de EOx. La administración únicamente de vino tinto sin diluir presentó efectos tóxicos. Conclusiones: nuestros resultados generan expectativas sobre el empleo de sustancias como el vino tinto en la protección o modulación del daño genotóxico, lo que podría conducir a su aplicación en los procesos de carcinogénesis y mutagénesis.

  8. EPITOPE-BASED VACCINE FOR THE TREATMENT OF DER F 3 ALLERGY.

    PubMed

    Zhan, Xiaodong; Li, Chaopin; Jiang, Yuxing; Li, Na

    2015-12-01

    Introducción: el asma alérgica está causada por la exposición a los ácaros del polvo casero (HDM). Der f 3 se cree que es uno de los principales alérgenos en los ácaros del asma alérgica. El trabajo consistió en identificar las características inmunológicas de la vacuna basada en epítopo-Der f 3 que contienen las células T y las células B. Métodos: se generaron líneas de células T a partir de células mononucleares de sangre periférica de pacientes alérgicos a Der f 3. Tres epítopos de células T y cinco epítopos de células B de Der f 3, que hemos identificado previamente, fueron seleccionados para diseñar un polipéptido (denominados péptidos Der f 3). Construcciones de DNA que codifican estos péptidos Der f 3 se expresaron en Escherichia coli. Las líneas de células T se estimularon con los péptidos y se utilizaron en el ensayo por su capacidad proliferativa y la producción de citoquinas. Resultados: el plásmido pET28a (+) - Der f 3-péptidos se construyó y se expresaron en E. coli BL21, y la proteína de Der f 3-péptidos se purificó y se confirmaron mediante transferencia de Western. Los Der f 3-péptidos fueron reconocidos por los clones de células T procedentes de pacientes alérgicos. Valor SI de Der f 3 grupo y f grupo 3-péptidos Der eran tanto mayor que la del grupo de PBS (P.

  9. Geologic map of the Ute Mountain 7.5' quadrangle, Taos County, New Mexico, and Conejos and Costilla Counties, Colorado

    USGS Publications Warehouse

    Thompson, Ren A.; Turner, Kenzie J.; Shroba, Ralph R.; Cosca, Michael A.; Ruleman, Chester A.; Lee, John P.; Brandt, Theodore R.

    2014-01-01

    The Ute Mountain 7.5' quadrangle is located in the south-central part of the San Luis Basin of northern New Mexico, in the Rio Grande del Norte National Monument, and contains deposits that record volcanic, tectonic, and associated alluvial and colluvial processes over the past four million years. Ute Mountain has the distinction of being one of the largest intermediate composition eruptive centers of the Taos Plateau, a largely volcanic tableland occupying the southern portion of the San Luis Basin. Ute Mountain rises to an elevation in excess of 3,000 m, nearly 700 m above the basaltic plateau at its base, and is characterized by three distinct phases of Pliocene eruptive activity recorded in the stratigraphy exposed on the flanks of the mountain and in the Rio Grande gorge. Unconformably overlain by largely flat-lying lava flows of Servilleta Basalt, the area surrounding Ute Mountain records a westward thickening of basin-fill volcanic deposits interstratified in the subsurface with Pliocene basin-fill sedimentary deposits derived from older Tertiary and Precambrian sources to the east. Superimposed on this volcanic stratigraphy are alluvial and colluvial deposits derived from the flanks of Ute Mountain and more distally-derived alluvium from the uplifted Sangre de Cristo Mountains to the east, that record a complex temporal and stratigraphic succession of Quaternary basin deposition and erosion. Pliocene and younger basin deposition was accommodated along predominantly north-trending fault-bounded grabens. These poorly exposed fault scarps cutting lava flows of Ute Mountain volcano. The Servilleta Basalt and younger surficial deposits record largely down-to-east basinward displacement. Faults are identified with varying confidence levels in the map area. Recognizing and mapping faults developed near the surface in young, brittle volcanic rocks is difficult because: (1) they tend to form fractured zones tens of meters wide rather than discrete fault planes, (2

  10. [In Process Citation].

    PubMed

    Durán Agüero, Samuel; Fernández Godoy, Eloina; Carrasco Piña, Elena

    2016-02-16

    Introducción: la hiperglicemia es la característica principal de la diabetes (DM). La restricción de CHO en la dieta presenta el mayor efecto en la disminución de los niveles de glucosa en sangre tanto en DM 1 y 2.Objetivo: asociar la ingesta de macro y micronutrientes con el control metabólico de pacientes con diabetes tipo 2.Material y métodos: se entrevistó a 714 pacientes diabéticos tipo 2 de ambos sexos, entre 27 y 90 años, en centros de salud familiar de Santiago de Chile. Se les aplicó una encuesta alimentaria y una evaluación antropométrica. Se realizó prueba de regresión logística, se estimó además el valor del Odds Ratio (OR) y su correspondiente intervalo de confianza (IC).Resultados: el IMC promedio fue de 30,8 ± 5,7 kg/m2, el 29,8% de los sujetos tenía una HbA1c compensada. Se puede observar que solo la ingesta elevada de carbohidratos (percentil 75) se asoció con un incremento en el riesgo de tener HbA1c elevada OR = 2,7 (IC 95% 1,5-4,8; p < 0,001).Conclusiones: la ingesta elevada de carbohidratos de rápida absorción, altos en sacarosa y bajos en fibra se asocia como factor de riesgo en el incremento de HbA1c. La ingesta total de energía y el patrón de alimentación saludable se debe priorizar sobre la distribución de macronutrientes. Es importante la asesoría de un experto en nutrición especializado en diabetes quien, en colaboración con el equipo médico, debe determinar el tratamiento para cumplir con los objetivos individuales del paciente.

  11. Sulfur isotope study of the Velardeña skarn (Zn-Pb), Durango, Mexico

    NASA Astrophysics Data System (ADS)

    Jimenez, A.

    2012-04-01

    Sulfur isotope study of the Velardeña skarn (Zn-Pb), Durango, Mexico Abigail Jimenez-Franco1*, Pura Alfonso Abella2, Carles Canet3, Eduardo González-Partida4 1 Posgrado en Ciencias de la Tierra, Universidad Nacional Autónoma de México, Ciudad Universitaria, Delegación Coyoacán, 04510 México D.F., Mexico 2 Departament d'Enginyeria Minera i Recursos Naturals, Universitat Politècnica de Catalunya, Av de Les Bases de Manresa 61-73, 08242 Manresa. 3Instituto de Geofísica, Universidad Nacional Autónoma de México, Ciudad Universitaria, Delegación Coyoacán, 04510 México D.F., Mexico 4Centro de Geociencias, Universidad Nacional Autónoma de México, Campus Juriquilla, Boulevard Juriquilla 3001, 76230 Santiago de Querétaro, Qro., Mexico The Velardeña mining district is located in north-eastern part of the state of Durango, in northern of Mexico. The ore deposit is a lead-zinc, garnet-rich skarn developed at the contact between granite porphyry dikes (Eocene) and well-laminated limestones with interbedded chert (Albian-Cenomanian). A study of sulfur isotopes has been carried out in various sulfide minerals of the ores of Velardeña, in order to: (a) constrain the possible sources of sulfur and, therefore, better understand the sulfide mineralizing processes, and (b) to estimate the temperature of the ore-forming stage of the skarn. Sulfur isotope analyses were performed in 21 pure fractions of sulfide minerals of the ore mineralization (pyrite, chalcopyrite, sphalerite and galena). The mineral separation was performed using a series of sieves, and the purity of the samples was verified under a binocular microscope. Isotopic analyses were done on a Finnigan MAT Delta C flow elemental analyzer coupled to a TC-EA, according with the method of Giesemann et al. (1974). The δ34S values of the analyzed sulfides range mostly between -0.6 and +2.6 ‰ (relative to the CDT standard). These values are indicative of a magmatic source of sulfur. A single analysis falls

  12. 7th International Conference on Mathematical Methods in Physics

    NASA Astrophysics Data System (ADS)

    Bonora, L.; Bytsenko, A. A.; Guimarães, M. E. X.; Helayël-Neto, J. A.

    The 7th International Conference on Mathematical Methods in Physics took place in the Centro Brasileiro de Pesquisas Físicas (CBPF/MCT), Rio de Janeiro - RJ, Brazil, from 16 to 20 April 2012, and was jointly organized by the following Institutions: Centro Brasileiro de Pesquisas Físicas (CBPF/MCT), The Abdus Salam International Centre for Theoretical Physics (ICTP, Italy), Instituto Nacional de Matemática Pura e Aplicada (IMPA, Brazil), The Academy of Sciences for the Developing World (TWAS, Italy) and The Scuola Internazionale di Studi Avanzati (SISSA,Italy). The Organizing Committees were composed by: E. ABDALLA (USP, Brazil), L. BONORA (SISSA, Italy), H. BURSZTYN (IMPA, Brazil), A. A. BYTSENKO (UEL, Brazil), B. DUBROVIN (SISSA, Italy), M.E.X. GUIMARÃES (UFF, Brazil), J.A. HELAYËL-NETO (CBPF, Brazil). Advisory Committee: A. V. ASHTEKAR (Penn State University, U.S.A.), V. M. BUCHSTABER (Steklov Mathematical Institute, Russia), L. D. FADDEEV (St. Petersburg Dept. of Steklov Mathematical Institute, Russia), I. M. KRICHEVER (Columbia Univ., U.S.A./ Landau Institute of Theoretical Physics, Russia), S. P. NOVIKOV (Univ. of Maryland, U.S.A./Landau Institute of Theoretical Physics, Russia), J. PALIS (IMPA, Brazil), A. QADIR (National University of Sciences and Technology, Pakistan), F. QUEVEDO (ICTP, Italy), S. RANDJBAR-DAEMI (ICTP, Italy), G. THOMPSON (ICTP, Italy), C. VAFA (Harvard University, U.S.A.). The Main Goal: The aim of the Conference was to present the latest advances in Mathematical Methods of Physics to researchers, young scientists and students of Latin America in general, and Brazil in particular, in the areas of High Energy Physics, Cosmology, Mathematical Physics and Applied Mathematics. The main goal was to promote an updating of knowledge and to facilitate the interaction between mathematicians and theoretical physicists, through plenary sessions and seminars. This Conference can be considered as a part of a network activity in a special effort to

  13. Optimized multiple quantum MAS lineshape simulations in solid state NMR

    NASA Astrophysics Data System (ADS)

    Brouwer, William J.; Davis, Michael C.; Mueller, Karl T.

    2009-10-01

    /Linux Operating system: UNIX/Linux Has the code been vectorised or parallelized?: Yes RAM: Example: (1597 powder angles) × (200 Samples) × (81 F2 frequency pts) × (31 F1 frequency points) = 3.5M, SMP AMD opteron Classification: 2.3 External routines: OCTAVE ( http://www.gnu.org/software/octave/), GNU Scientific Library ( http://www.gnu.org/software/gsl/), OPENMP ( http://openmp.org/wp/) Nature of problem: The optimal simulation and modeling of multiple quantum magic angle spinning NMR spectra, for general systems, especially those with mild to significant disorder. The approach outlined and implemented in C and OCTAVE also produces model parameter error estimates. Solution method: A model for each distinct chemical site is first proposed, for the individual contribution of crystallite orientations to the spectrum. This model is averaged over all powder angles [1], as well as the (stochastic) parameters; isotropic chemical shift and quadrupole coupling constant. The latter is accomplished via sampling from a bi-variate Gaussian distribution, using the Box-Muller algorithm to transform Sobol (quasi) random numbers [2]. A simulated annealing optimization is performed, and finally the non-linear jackknife [3] is applied in developing model parameter error estimates. Additional comments: The distribution contains a script, mqmasOpt.m, which runs in the OCTAVE language workspace. Running time: Example: (1597 powder angles) × (200 Samples) × (81 F2 frequency pts) × (31 F1 frequency points) = 58.35 seconds, SMP AMD opteron. References:S.K. Zaremba, Annali di Matematica Pura ed Applicata 73 (1966) 293. H. Niederreiter, Random Number Generation and Quasi-Monte Carlo Methods, SIAM, 1992. T. Fox, D. Hinkley, K. Larntz, Technometrics 22 (1980) 29.

  14. METABOLIC EFFECTS OF Β-GLUCANS (SACCHAROMYCES CEREVISAE) PER OS ADMINISTRATION IN RATS WITH STREPTOZOTOCIN-INDUCED DIABETES.

    PubMed

    Vieira Lobato, Raquel; De Oliveira Silva, Viviam; Francelino Andrade, Eric; Ribeiro Orlando, Débora; Gilberto Zangeronimo, Márcio; Vicente de Sousa, Raimundo; José Pereira, Luciano

    2015-07-01

    Introdución: los beta-glucanos (BG) derivados de tejidos vegetales se ha informado que muestran efectos metabólicos. Por el contrario, esas fibras aisladas de levadura parecen estar más relacionadas con la modulación de la respuesta inmune. Dado que los individuos con diabetes son más susceptibles a la exacerbación de los signos inflamatorios, la ingestión de fibras sí podría conjugar ambos efectos metabólicos e inmunológicos, lo cual sería de gran importancia. Objetivo: el objetivo de este estudio fue investigar los efectos de la ingestión de los BG —Saccharomyses cerevisiae— en el perfil glucémico y la lipoproteína de ratas diabéticas. Metodos: en el diseño de delineación, totalmente precario, fueron utilizadas 24 ratas Wistar macho adultas distribuidas en cuatro grupos, con un modelo factorial 2 x 2 (con y sin diabetes, con y sin BG). La diabetes mellitus fue inducida por la inyección intraperitoneal de un 80 mg/kg de estrepzotocina. Por lo tanto, los animales con glucemia en ayunas de más de 250 mg/dl fueron considerados diabéticos. Cuarenta y ocho horas después de la inducción, las ratas recibieron dosis diarias de 30 mg/kg de BG o solución salina mediante alimentación forzada durante 28 días. Resultados y discusión: los grupos con DM presentó el mayor índice glucémico y menores niveles de péptido C que los grupos de control, además de reducir el aumento de peso y un mayor consumo de la ración, la ingestión de agua y el volumen urinario. Los niveles de colesterol total (CT), LDL-C + VLDL-C, triacilglicéridos plasmáticos (TAG) y alanina aminotransferasa (ALT) también fueron más altos en los animales diabéticos (p < 0,05), y había alteraciones en los niveles de HDL-C. La ingestión de BG redujo las concentraciones de glucosa en sangre (30%), TAG (32%) y ALT (41%) (p < 0.05). No se observaron alteraciones hepáticas en ninguno de los grupos. Además, los animales diabéticos presentaron un aumento de la relación cripta

  15. MALNUTRITION IN PATIENTS WITH GASTROINTESTINAL CANCER: EFFECTIVENESS OF DIFFERENT DIAGNOSTIC METHODS.

    PubMed

    Dias do Prado, Corina; Alvares Duarte Bonini Campos, Juliana

    2015-07-01

    Objetivo: estimar la efectividad de los diferentes métodos para la identificación y/o presencia de desnutrición en las personas con riesgo de cáncer gastrointestinal. Métodos: los participantes fueron 143 pacientes con cáncer gastrointestinal, atendidos en la sala del Hospital Clínico de Oncología Amaral Carvalho (Jau-SP). No se excluyeron los pacientes ingresados en la unidad de cuidados intensivos, con enfermedad terminal o con miembros amputados que recibieron transfusiones de sangre en el último mes, con hemorragias clínicamente relevantes, que recibieron albúmina intravenosa y aquellos con infección no controlada. El estado nutricional de los participantes se clasificó de acuerdo a la relación Peso Real y Peso Habitual (PR/PH), Índice de Masa Corporal (IMC), Índice de Riesgo Nutricional (IRN) y porcentaje de ajuste (% score). Como método estándar de oro se utilizó la Evaluación Global Subjetiva. Fue evaluada la eficacia de los métodos para detectar el riesgo de desnutrición o la presencia de desnutrición. La curva ROC fue construido y su área (AUROC) se estimó. Las áreas se compararon mendiante z estadística. Para cada método resuelto el mejor punto de corte. Resultados: de los pacientes, el 74,1% había avanzado en el estado de la enfermedad y el 83,2% fueron sometidos a métodos quimioterápicos. Todos los métodos de tratamiento mostraron una adecuada capacidad discriminatoria para detectar el riesgo de desnutrición y la presencia de la misma. El IMC fue significativamente mejor para la detección de la desnutrición que para el riesgo de desnutrición. El riesgo PR/PH fue significativamente mejor para detectar el riesgo de desnutrición que otros métodos. Los puntos de corte fueron inferiores a los puntos de corte recomendados para población normativa con los métodos PR/PH, NRI y porcentaje de ajuste (% score). Para el punto de corte del IMC fue mayor que el recomendado para la población normativa. Conclusión: los m

  16. Competing Interests and Concerns in the Rio Grande Basin: Mountain Hydrology, Desert Ecology, Climate Change, and Population Growth

    NASA Astrophysics Data System (ADS)

    Rango, A.

    2004-12-01

    In the mountainous American Southwest, the Rio Grande basin is a prime example of how conflicts, misconceptions, and competition regarding water can arise in arid and semi-arid catchments. Much of the Rio Grande runoff originates from snow fields in the San Juan Mountains of southern Colorado and the Sangre De Cristo Mountains of northern New Mexico, far from population centers. Large and rapidly growing cities, like Albuquerque, Las Cruces, El Paso, and Juarez, are located along the Rio Grande where it flows through the Chihuahuan Desert, the largest desert in North America(two NSF Long Term Ecological Research sites are located in the desert portion of the basin). As a result, the importance of snowmelt, which makes up 50-75% or more of the total streamflow in sub-basins above Elephant Butte Reservoir(in south central New Mexico) is hardly known to the general public. Streamflow below Elephant Butte Reservoir is rainfall driven and very limited, with the lower basin receiving only 170-380 mm of precipitation annually, most of it occurring during the months of July-September. Extreme events, such as drought and flooding, are not unusual in arid basins, and they are of increasing concern with regard to changes in frequency of such events under the impending conditions of climate change. Current water demands in the basin already exceed the water supply by 15% or more, so streamflow forecasts(especially from snowmelt runoff) are extremely valuable for efficient water management as well as for proper apportionment of water between Colorado, New Mexico, and Texas under the Rio Grande Compact of 1938 and between the U.S. and Mexico under the Treaty of 1906. Other demands on the water supply include Indian water rights, flood regulation, irrigated agriculture, municipal and industrial demands, water quality, riverine and riparian habitat protection, endangered and threatened species protection, recreation, and hydropower. To assess snow accumulation and cover and to

  17. [In Process Citation].

    PubMed

    Gonçalves Schemitt, Elizângela; Raskopf Colares, Josieli; Minuzzo Hartmann, Renata; Morgan-Martins, María Isabel; Marroni, Cláudio Augusto; Tuñón, M Jesús; Possa Marroni, Norma

    2016-01-01

    Introducción: la insuficiencia hepática fulminante (IHF) es un síndrome clínico poco frecuente, que se caracteriza por una disfunción hepática severa y repentina. La tioacetamida (TAA) es una hepatotoxina cuya administración puede inducir necrosis centrolobulillar en las células hepáticas y aumentar la formación de especies reactivas de oxígeno y la peroxidación lipídica en ratas. La glutamina es un precursor para la síntesis de glutatión. Objetivo: el objetivo del estudio es evaluar los efectos antioxidantes de la glutamina en un modelo de rata de IHF inducida por TAA. Métodos: ratas macho Wistar se dividieron en cuatro grupos de acuerdo con el tratamiento y el tiempo de evaluación: control, glutamina (25 mg/kg), tioacetamida (400 mg/kg) y tioacetamida más glutamina. Los animales se evaluaron después de 24, 36 y 48 horas. Se recogieron muestras de sangre para el análisis de los niveles de aspartato aminotransferasa (AST), alanina aminotransferasa (ALT), fosfatasa alcalina (AP), bilirrubina total (TB) y creatinina (CRE), y muestras de hígado para evaluar la peroxidación lipídica, las sustancias reactivas al ácido tiobarbitúrico (TBARS), la actividad de las enzimas antioxidantes superóxido dismutasa (SOD), glutatión peroxidasa (GPx), catalasa (CAT) y glutatión S-transferasa (GST). Además se midieron mediante inmunohistoquímica el factor nuclear kappa N (NF-κB), el fator de necrosis tumoral (TNF-α) y la óxido nítrico sintasa inducible (iNOS). Resultados: la TAA causó alteraciones en los parámetros bioquímicos e histológicos, y el aumento de los marcadores del proceso inflamatorio. Los niveles de TBARS y la actividad de SOD y GST fueron significativamente inferiores en los grupos de glutamina en comparación con TAA. La actividad de CAT se incrementó en los animales tratados con glutamina en comparación con la TAA. La actividad GPx también fue menor a las 36 y 48 h en los animales tratados com glutamina. El daño tisular y

  18. A COCONUT EXTRA VIRGIN OIL-RICH DIET INCREASES HDL CHOLESTEROL AND DECREASES WAIST CIRCUMFERENCE AND BODY MASS IN CORONARY ARTERY DISEASE PATIENTS.

    PubMed

    Cardoso, Diuli A; Moreira, Annie S B; de Oliveira, Glaucia M M; Raggio Luiz, Ronir; Rosa, Glorimar

    2015-11-01

    Introducción: el aceite de coco (Cocos nucifera L.) virgen extra contiene una alta proporción de ácidos grasos de cadena media que parecen contribuir a la reducción del peso y podría ayudar en la prevención secundaria de la enfermedad arterial coronaria (EAC). Objetivo: evaluar el efecto del tratamiento nutricional asociado con el consumo de aceite de coco virgen extra en los parámetros antropométricos y el perfil lipídico. Métodos: se realizó un estudio longitudinal de 116 adultos de ambos sexos que presentan CAD. Los pacientes fueron seguidos en dos etapas: en la primera etapa (basal-3 meses), se llevo a cabo un tratamiento nutricional intensivo. En la segunda etapa (3-6 días), los sujetos fueron divididos en dos grupos: grupo asociado con el consumo de aceite extra virgen de coco (GDOC) y el grupo de dieta (GD). Se realizaron mediciones mensuales antropométricas: peso, circunferencia de la cintura (CC), circunferencia del cuello (PP) e índice de masa corporal (IMC). Se tomó la presión arterial y muestras de sangre recogidas en ayunas durante 12 horas para el análisis de colesterol total y lipoproteínas, apoproteínas (Apo A-1 y B), glucosa, hemoglobina glucosilada (HbA1c) e insulina (I). Se compararon los promedios al principio y al final del estudio mediante el test t de Student-independiente. Se ajustó la presión arterial diastólica por el IMC mediante ANOVA. Los análisis se realizaron con el paquete estadístico SPSS, siendo significativa p < 0.05. Resultados: la edad media de la población fue de 62,4 ± 7,7 años, el 63,2% hombres, 70% mayores, el 77,6% con infarto de miocardio, el 52,6% con angina de pecho y el 100% con hipertensión arterial y dislipidemia. En la primera etapa del tratamiento nutricional se redujeron las concentraciones de insulina, peso, WC, IMC y PP, HbA1C, HOMA-IR y rápido, sin cambiar otros parámetros. En la segunda etapa del estudio se observó que la GDOC mantiene la reducción del peso, BMI, WC, con una

  19. The Pajarito Plateau: a bibliography

    USGS Publications Warehouse

    Mathien, Frances Joan; Allen, Craig D.; Steen, Charlie R.

    1993-01-01

    Pajarito Plateau is described as the high tableland that lies between the Jemez Mountains on the west and the Rio Grande on the east. From north to south, it extends from the Chama Valley to La Cañada de Cochiti (Hewett 1906:14)(Figure 1). Because human activity rarely stops at such definite boundaries, major ethnographic studies of Tewa (San Ildefonso and Santa Clara) and Keres (Cochiti) linguistic groups are included. (Even though most of the historic pueblos occupied by the Tewa and Keres are not located on the Pajarito Plateau, oral traditions and archaeological data suggest that these groups once occupied sites on the plateau.) Towa studies are not included because Steen believed Towa ancestors were not involved in major cultural developments of the Pajarito Plateau. In addition, a bibliography of the Jemez area (home of Towa people) has been prepared by Michael Elliott (1982) and included with his nomination of large Pueblo sites near Jemez Springs to the National Register of Historic Places that is on file at the Museum of New Mexico, Laboratory of Anthropology, in Santa Fe. Both Steen and Mathien included references to geographically and historically related material that does not focus on the Pajarito Plateau but, nonetheless, is important to understanding the area's archaeology and physical environment, for example, lithic resources available from Cerro Pedernal or in the Sangre de Cristo Mountains.

  20. Cut-off values of waist circumference to predict metabolic syndrome in obese adolescents.

    PubMed

    Masquio, Deborah Cristina Landi; Ganen, Aline de Piano; Campos, Raquel Munhoz da Silveira; Sanches, Priscila de Lima; Corgosinho, Flávia Campos; Caranti, Danielle; Tock, Lian; de Mello, Marco Túlio; Tufik, Sergio; Dâmaso, Ana R

    2015-04-01

    Introducción: El síndrome metabólico es una constelación de alteraciones metabólicas relacionadas con la obesidad abdominal, la inflamación y la resistencia a la insulina, lo que aumenta las enfermedades cardiovasculares y la mortalidad. Los objetivos del presente estudio fueron determinar la prevalencia de comorbilidades y parámetros alterados en adolescentes obesos con y sin SM, y determinar los puntos de corte de la circunferencia de cintura para predecir SM. Métodos: 195 adolescentes obesos y se los dividió según síndrome metabólico diagnóstico basado en criterios de la IDF. Los análisis de sangre se midieron de glucosa, lípidos, enzimas hepáticas, la adiponectina y leptina. Resistencia a la insulina se evaluó mediante HOMA-IR, QUICKI y HOMA-AD. Se obtuvieron ecografía visceral, subcutánea y grasa hepática. La composición corporal se calcula por el sistema BOD POD. Resultados: Se observó una prevalencia del 25% de síndrome metabólico Mets (n = 50). El grupo grupo con síndrome metabólico presentó mayor masa corporal, índice de masa corporal, grasa corporal (kg), sin grasa masa significativa (kg), circunferencia de la cintura, la grasa visceral, la glucosa, la insulina, resistencia a la insulina, colesterol total, LDL-c, VLDL-c, triglicéridos, enzimas hepáticas, enfermedad no alcohólica del hígado graso (EHNA) y la presión arterial. Se observaron QUICKI significativamente menor y la adiponectina en el grupo con síndrome metabólico. El grupo con síndrome metabólico presentaron significativa proporción de leptina / adiponectina mayor en comparación con los que no tienen síndrome metabólico. Puntos de corte de 111,5 cm para los niños y 104,6 cm para las niñas de la circunferencia de cintura se sugirieron para predecir el síndrome metabólico. Además, la circunferencia de la cintura fue positivamente correlacionada con la grasa visceral y el número de parámetros del síndrome metabólico. Conclusión: El grupo con s

  1. APPLICATILITY OF THE VISCERAL ADIPOSITY INDEX (VAI) IN THE PREDICTION OF THE COMPONENTS OF THE METABOLIC SYNDROME IN ELDERLY.

    PubMed

    Goldani, Heloisa; Adami, Fernanda Scherer; Antunes, Maria Terezinha; Rosa, Luis Henrique; Fassina, Patrícia; Quevedo Grave, Magali Terezinha; Morelo Dal Bosco, Simone

    2015-10-01

    La evaluación nutricional puede detectar un estado de desnutrición, sobrepeso y riesgo cardiometabólico en los ancianos. Fácil de aplicar, los instrumentos permiten la identificación de factores de riesgo de enfermedades cardiovasculares (ECV). Objetivo: analizar la aplicabilidad del Índice de Adiposidad Visceral (VAI) en la predicción de los componentes del SM en los ancianos. Métodos: estudio transversal con 221 personas mayores con una edad media de 70,65 ± 7,34 años; 53,4% mujeres y 46,4% hombres. Se obtuvieron peso, talla, circunferencia de la cintura (CC), glucosa en ayunas, triglicéridos (TG), colesterol total (CT), colesterol HDL (HDL-C), colesterol LDL (LDL-C) y presión arterial (PA), así como información acerca del estilo de vida. No se calcularon el índice de masa corporal (IMC), la relación cintura-cadera (WHR) y el VAI. Las medidas de adiposidad se compararon con los componentes de la MS, y para el VAI no se determinó la capacidad de predecir la ocurrencia de los componentes del SM. Resultados: el análisis de la asociación entre las variables bioquímicas y de presión y los componentes del SM con los indicadores antropométricos de obesidad evidencia que existe una correlación directa y significativa entre el índice de masa corporal, el peso y el VAI con la glucosa en sangre, colesterol HDL y TG (p < 0,01); el VAI fue el indicador con la correlación más fuerte para todos los parámetros. El WC se asoció significativamente con el HDL y TG, y el RHO solo con el HDL. En lo que respecta a la aplicabilidad de la VAI en la determinación del riesgo relativo de aparición de los componentes del SM, el VAI era buen predictor de obesidad abdominal (OR = 1,27, p < 0,001), hiperglucemia (OR = 1,10, p = 0,043), hipertrigliceridemia (OR = 3,64, p < 0,001) y bajos niveles de HDL-c (OR = 2,26, p < 0,001). Conclusión: el VAI mostró asociación con componentes del síndrome metabólico en los hombres y las mujeres con mayor riesgo de obesidad

  2. Stratigraphic relationships of Cretaceous and early Tertiary rocks of a part of northwestern San Juan basin

    USGS Publications Warehouse

    Baltz, Elmer Harold

    1953-01-01

    sandstone facies of the Nacimiento and San Jose formations are correlated with similar facies of these formations on the east side of the San Juan Basin. Folding along the borders of the Central basin was completed prior to deposition of the youngest San Joss beds, and they were probably widely distributed outside of the Central Basin in Eocene time. In Pliocene time, the San Juan region was beveled by the San Juan peneplain. Rejuvenation of the San Juan Mountains in late Pliocene time caused erosion in the mountains and deposition of the Bridgetimber gravel in the San Juan Basin. Uplift in Pleistocene time caused large-scale erosion in the Bridge Timber Mountain area and gravel-covered terraces represent the various stages of uplift and erosion. The stratigraphic relationships of uppermost Cretaceous and lower Tertiary rocks in the Bridge Timber Mountain area are similar to recently described relationships of equivalent rocks in other parts of the San Juan Basin. The southwestern lobe of the Pictured Cliffs sandstone was derived from older Cretaceous source areas to the southwest and deposited in the seaway which was retreating northeastward. The northeastern lobe consists of reworked Cretaceous sediments eroded from the flanks of the rising San Juan zone and Sangre de Cristo upwarp and deposited in an arm of the sea which was isolated by uplift of the mountain masses. This arm of the sea was forced to retreat to the southeast as sediments of the Fruitland, Kirtland, Animas, and Ojo Alamo formations were deposited in' the basin. The Animas formation which was derived from hi6hlands to the northeast spread progressively to the southwest and interfingered with lesser amounts of Fruitland and Kirtland sediments derived from the southwest. In latest Cretaceous or earliest Paleocene time folding began along the Hogback 'monocline' in northern and western San Juan Basin and sediments were eroded from the uplifted platforms around the margin of the Central Basin and rede

  3. Association between magnesium-deficient status and anthropometric and clinical-nutritional parameters in posmenopausal women.

    PubMed

    López-González, Beatriz; Molina-López, Jorge; Florea, Daniela Ioana; Quintero-Osso, Bartolomé; Pérez de la Cruz, Antonio; Planells del Pozo, Elena Ma

    2014-03-01

    Introducción: Durante la menopausia se produce un aumento de peso y de pérdida de masa ósea debido a la disminución hormonal producida durante este periodo y a otros factores como la nutrición. La deficiencia de magnesio podría ser un factor de riesgo para la obesidad y la osteoporosis. Objetivo: Evaluar el estado clínico-nutricional en una población de mujeres postmenopáusicas, evaluando la ingesta y los niveles séricos de magnesio, y su correlación con parámetros antropométricos, como el índice de masa corporal (IMC) y la grasa corporal, así como con parámetros bioquímicos asociados. Sujetos y Metodología: En el estudio participaron 78 mujeres sanas en situación de postmenopausia de la provincia a de Granada, con edades comprendidas entre los 44-76 años. La muestra se dividió en dos grupos de edad: grupo 1, mujeres postmenopáusicas con edad menor de 58 años y grupo 2, de edad mayor o igual a 58 años. Se registraron parámetros antropométricos y se valoró la ingesta nutricional mediante recordatorio de 72 horas, obteniendo las RDAs a través del programa Nutriber®. Para valorar los parámetros bioquímicos se realizó una extracción de sangre y el magnesio se analizó mediante espectrofotometría de absorción atómica de llama (FAAS) en muestras de eritrocitos y plasma previamente mineralizadas por vía húmeda. Resultados: Nuestros resultados muestran que el 37.8% de las mujeres presentan sobrepeso. La ingesta de magnesio encontrada en nuestra población es insuficiente en el 36% de las mujeres, mientras que la deficiencia de magnesio plasmático y eritrocitario corresponde al 23% y el 72% de las mujeres, respectivamente. Se observaron correlaciones significativas positivas entre el aporte de magnesio en la dieta y el aporte de calcio, de fósforo, y los niveles plasmáticos de prealbúmina, además de con una menor relación cintura/cadera. Los niveles de magnesio en eritrocito se correlacionaron con los niveles de triglicéridos y

  4. Independent and combined influence of the FTO rs9939609 and MC4Rrs17782313 polymorphisms on hypocaloric diet induced changes in body mass and composition and energy metabolism in non-morbid obese premenopausal women.

    PubMed

    Labayen, Idoia; Margareto, Javier; Maldonado-Martin, Sara; Gorostegi, Ilargi; Illera, Maitane; Medrano, María; Barrenechea, Lurdes; Larrarte, Eider

    2015-05-01

    Objetivo: Examinar la influencia individual y combinada de los polimorfismos genéticos FTO rs9939609 y MC4R rs17782313 en los cambios en la masa grasa (MG), gasto energético en reposo (GER), leptina y tirotropina (TSH) tras una intervención de 12 semanas de duración con dieta hipocalórica en mujeres pre-menopáusicas con obesidad no mórbida. Métodos: Se evaluaron al inicio y al final de la intervención la MG (absorciometría dual de rayos X), el GER (calorimetría indirecta) y los niveles de leptina y TSH en sangre en 77 mujeres (edad: 36.8±7.0 años) obesas (IMC: 33.9±2.8kg/m2). Resultados: No se observaron diferencias estadísticamente significativas (Ps>0.1) entre las portadores y las no portadoras del alelo A del FTOrs9939609 (TT vs. portadores del alelo) en los cambios en la masa corporal (-8.6±3.2% vs. -8.7±3.3 %), MG (12.8±4.7% vs. –12.9±6.3%), GER (-11.3±4.7 vs. -9.4±8.1%), leptina (-34.1±25.1% vs. -43.5±24.1%) y TSH (5.2±34.5% vs. -1.7±27.1%). Tampoco se observaron diferencias estadísticamente significativas en los cambios en la masa corporal (-8.6±3.6% vs. -8.9±2.6%), MG (-12.7±6.1% vs. -13.4±5.3%), GER (-9.8±7.4% -9.4±9.4%), leptina (-39.0±26.9% vs. -44.8±18.4%) y TSH (-1.0±30.0% vs. 1.5±26.5%) entre las participantes portadoras y no portadoras del alelo C del MC4Rrs17782313 (Ps>0.3). Finalmente, no se encontraron diferencias estadísticamente significativas en los cambios en la masa y composición corporal, el GER, o los niveles de leptina y TSH entre mujeres no portadoras de alelos de riesgo, portadoras del alelo C del MC4Rrs17782313, portadoras del alelo A del FTOrs9939609 y portadoras de los dos alelos de riesgo (A y C) al final de las 12 semanas de intervención con dieta hipocalórica (Ps>0.1). Conclusión: Ser portador del alelo de riesgo A del FTOrs9939609 y/o del alelo de riesgo C del MC4Rrs17782313 no influye en la pérdida de masa grasa o en el descenso del GER en mujeres obesas tras 12 semanas de intervenci

  5. Analysis of the medication reconciliation process conducted at hospital admission.

    PubMed

    Contreras Rey, María Beatriz; Arco Prados, Yolanda; Sánchez Gómez, Ernesto

    2016-06-01

    fueron y en 93 (29,8%) la aceptación no procedía por un cambio en la situación del paciente. Las mayores oportunidades de mejora se identificaron en los servicios de Digestivo, Medicina Interna y Cirugía General y en los grupos terapéuticos: sangre y órganos hematopoyéticos, sistema cardiovascular y sistema nervioso. Conclusiones: En nuestro hospital solo una tercera parte de las intervenciones fueron aceptadas y reconocidas como errores de conciliación. No obstante, la conciliación de la medicación al ingreso realizada por un farmacéutico mostró ser útil en la identificación y prevención de errores de medicación. Un mejor entendimiento de los casos en los que las intervenciones no fueron aceptadas podría mejorar el resultado en el futuro.

  6. [In Process Citation].

    PubMed

    Gonçalves Schemitt, Elizângela; Raskopf Colares, Josieli; Minuzzo Hartmann, Renata; Morgan-Martins, María Isabel; Marroni, Cláudio Augusto; Tuñón, M Jesús; Possa Marroni, Norma

    2016-03-25

    Introducción: la insuficiencia hepática fulminante (IHF) es un síndrome clínico poco frecuente, que se caracteriza por una disfunción hepática severa y repentina. La tioacetamida (TAA) es una hepatotoxina cuya administración puede inducir necrosis centrolobulillar en las células hepáticas y aumentar la formación de especies reactivas de oxígeno y la peroxidación lipídica en ratas. La glutamina es un precursor para la síntesis de glutatión. Objetivo: el objetivo del estudio es evaluar los efectos antioxidantes de la glutamina en un modelo de rata de IHF inducida por TAA. Métodos: ratas macho Wistar se dividieron en cuatro grupos de acuerdo con el tratamiento y el tiempo de evaluación: control, glutamina (25 mg/kg), tioacetamida (400 mg/kg) y tioacetamida más glutamina. Los animales se evaluaron después de 24, 36 y 48 horas. Se recogieron muestras de sangre para el análisis de los niveles de aspartato aminotransferasa (AST), alanina aminotransferasa (ALT), fosfatasa alcalina (AP), bilirrubina total (TB) y creatinina (CRE), y muestras de hígado para evaluar la peroxidación lipídica, las sustancias reactivas al ácido tiobarbitúrico (TBARS), la actividad de las enzimas antioxidantes superóxido dismutasa (SOD), glutatión peroxidasa (GPx), catalasa (CAT) y glutatión S-transferasa (GST). Además se midieron mediante inmunohistoquímica el factor nuclear kappa N (NF-κB), el fator de necrosis tumoral (TNF-α) y la óxido nítrico sintasa inducible (iNOS). Resultados: la TAA causó alteraciones en los parámetros bioquímicos e histológicos, y el aumento de los marcadores del proceso inflamatorio. Los niveles de TBARS y la actividad de SOD y GST fueron significativamente inferiores en los grupos de glutamina en comparación con TAA. La actividad de CAT se incrementó en los animales tratados con glutamina en comparación con la TAA. La actividad GPx también fue menor a las 36 y 48 h en los animales tratados com glutamina. El daño tisular y

  7. 2007 Rocky Mountain Section Friends of the Pleistocene Field Trip - Quaternary Geology of the San Luis Basin of Colorado and New Mexico, September 7-9, 2007

    USGS Publications Warehouse

    Machette, Michael N.; Coates, Mary-Margaret; Johnson, Margo L.

    2007-01-01

    Prologue Welcome to the 2007 Rocky Mountain Cell Friends of the Pleistocene Field Trip, which will concentrate on the Quaternary geology of the San Luis Basin of Colorado and New Mexico. To our best knowledge, Friends of the Pleistocene (FOP) has never run a trip through the San Luis Basin, although former trips in the region reviewed the 'Northern Rio Grande rift' in 1987 and the 'Landscape History and Processes on the Pajarito Plateau' in 1996. After nearly a decade, the FOP has returned to the Rio Grande rift, but to an area that has rarely hosted a trip with a Quaternary focus. The objective of FOP trips is to review - in the field - new and exciting research on Quaternary geoscience, typically research being conducted by graduate students. In our case, the research is more topically oriented around three areas of the San Luis Basin, and it is being conducted by a wide range of Federal, State, academic, and consulting geologists. This year's trip is ambitious?we will spend our first day mainly on the Holocene record around Great Sand Dunes National Park and Preserve, the second day on the Quaternary stratigraphy around the San Luis Hills, including evidence for Lake Alamosa and the 1.0 Ma Mesita volcano, and wrap up the trip's third day in the Costilla Plain and Sunshine Valley reviewing alluvial stratigraphy, the history of the Rio Grande, and evidence for young movement on the Sangre de Cristo fault zone. In the tradition of FOP trips, we will be camping along the field trip route for this meeting. On the night before our trip, we will be at the Great Sand Dunes National Park and Preserve's Pinyon Flats Campground, a group facility located about 2 miles north of the Visitors Center. After the first day's trip, we will dine and camp in the Bachus pit, about 3 miles southwest of Alamosa. For the final night (after day 2), we will bed down at La Junta Campground at the Bureau of Land Management (BLM) Wild and Scenic Rivers State Recreation Area, west of Questa

  8. [Effectiveness of plerixafor in patients undergoing mobilization autologous haematopoietic progenitor cell].

    PubMed

    Ruano Camps, R; Ortiz Pareja, M; Vidales Mancha, I; Muñoz Castillo, I M; Heiniger Mazo, A I

    2013-01-01

    Objetivo: Evaluar efectividad del tratamiento con plerixafor en pacientes sometidos a movilización para posterior autotrasplante de progenitores hematopoyéticos en nuestro hospital. Métodos: Estudio retrospectivo de todos los pacientes que hasta septiembre 2012, recibieron plerixafor en su esquema de movilización de progenitores hematopoyéticos a sangre periférica. Se revisaron las historias clínicas y los registros de dispensación de medicamentos de la consulta de pacientes externos. Las variables de efectividad utilizadas fueron: CD34/kg en producto de aféresis obtenidas, dosis y días recibidos de factor estimulante de colonias (G-CSF) y de plerixafor. Para cada paciente se comparó los resultados de efectividad del fármaco con los obtenidos para anteriores esquemas de movilización en los que no se utilizó plerixafor, en caso de tenerlos. Los datos se analizaron mediante IBM spss v19. Resultados: Un total de 24 pacientes recibieron plerixafor en nuestro hospital. Los diagnósticos se distribuyeron: 15 linfoma no Hodgkin , 6 pacientes con mieloma múltiple, 2 enfermedad de Hodgkin, y 1 coriocarcinoma diseminado. Los resultados de efectividad fueron: Movilización sin plerixafor (n = 18): 5 pacientes se movilizaron sólo con G-CSGF, 13 con G-CSF y quimioterapia. La dosis de G-CSF /día fue de 931,1 mcg (± 179,5), durante 9,5 días (± 4,7). El promedio de CD34/kg en producto obtenido fue de 0,2 células (± 0,5). Ningún paciente obtuvo producto suficiente (≥?2 x 106 células/kg) para el posterior autotrasplante. El 100 % de las movilizaciones fracasaron. Movilización con plerixafor (n = 24): 13 pacientes se movilizaron sólo con G-CSGF, 11 con G-CSF y quimioterapia. La dosis de G-CSF /día y de plerixafor promedio fue de 885,1 mcg (± 240,1) y 19,8 (± 4,4), respectivamente, administrados durante 8,9 (± 5,1) y 1,5 (± 0,6) días, respectivamente. El promedio de CD34/kg en producto obtenido fue de 2,3x106 células (±1,7) (p = 0,014, en relaci

  9. Hydrology of the San Luis Valley, south-central Colorado

    USGS Publications Warehouse

    Emery, P.A.; Boettcher, A.J.; Snipes, R.J.; Mcintyre, H.J.

    1969-01-01

    An investigation of the water resources of the Colorado part of the San Luis Valley was begun in 1966 by the U.S. Geological Survey, in cooperation with the Colorado Water Conservation Board. (See index map, fig. 1). The purpose of the investigation is to provide information for planning and implementing improved water-development and management practices. The major water problems in the San Luis Valley include (1) waterlogging, (2) waste of water by nonbeneficial evapotranspiration, (3) deterioration of ground-water chemical quality, and (4) failure of Colorado to deliver water to New Mexico and Texas in accordance with the Rio Grande Compact. This report describes the hydrologic environment, extent of water-resource development, and some of the problems related to that development. Information presented is based on data collected from 1966 to 1968 and on previous studies. Subsequent reports are planned as the investigation progresses. The San Luis Valley extends about 100 miles from Poncha Pass near the northeast corner of Saguache County, Colo., to a point about 16 miles south of the Colorado-New Mexico State line. The total area is 3,125 square miles, of which about 3,000 are in Colorado. The valley is nearly flat except for the San Luis Hills and a few other small areas. The Colorado part of the San Luis Valley, which is described in this report, has an average altitude of about 7,700 feet. Bounding the valley on the west are the San Juan Mountains and on the east the Sangre de Cristo Mountains. Most of the valley floor is bordered by alluvial fans deposited by streams originating in the mountains, the most extensive being the Rio Grande fan (see block diagram, fig. 2 in pocket). Most of the streamflow is derived from snowmelt from 4,700 square miles of watershed in the surrounding mountains. The northern half of the San Luis Valley is internally drained and is referred to as the closed basin. The lowest part of this area is known locally as the "sump." The

  10. Ground-Water Flow Direction, Water Quality, Recharge Sources, and Age, Great Sand Dunes National Monument, South-Central Colorado, 2000-2001

    USGS Publications Warehouse

    Rupert, Michael G.; Plummer, L. Niel

    2004-01-01

    Great Sand Dunes National Monument is located in south-central Colorado along the eastern edge of the San Luis Valley. The Great Sand Dunes National Monument contains the tallest sand dunes in North America; some rise up to750 feet. Important ecological features of the Great Sand Dunes National Monument are palustrine wetlands associated with interdunal ponds and depressions along the western edge of the dune field. The existence and natural maintenance of the dune field and the interdunal ponds are dependent on maintaining ground-water levels at historic elevations. To address these concerns, the U.S. Geological Survey conducted a study, in collaboration with the National Park Service, of ground-water flow direction, water quality, recharge sources, and age at the Great Sand Dunes National Monument. A shallow unconfined aquifer and a deeper confined aquifer are the two principal aquifers at the Great Sand Dunes National Monument. Ground water in the unconfined aquifer is recharged from Medano and Sand Creeks near the Sangre de Cristo Mountain front, flows underneath the main dune field, and discharges to Big and Little Spring Creeks. The percentage of calcium in ground water in the unconfined aquifer decreases and the percentage of sodium increases because of ionic exchange with clay minerals as the ground water flows underneath the dune field. It takes more than 60 years for the ground water to flow from Medano and Sand Creeks to Big and Little Spring Creeks. During this time, ground water in the upper part of the unconfined aquifer is recharged by numerous precipitation events. Evaporation of precipitation during recharge prior to reaching the water table causes enrichment in deuterium (2H) and oxygen-18 (18O) relative to waters that are not evaporated. This recharge from precipitation events causes the apparent ages determined using chlorofluorocarbons and tritium to become younger, because relatively young precipitation water is mixing with older waters

  11. PREFACE: Introduction to the proceedings of Dynamics Days South America 2010

    NASA Astrophysics Data System (ADS)

    Macau, Elbert E. N.; Pereira, Tiago; Prado, Antonio F. B. A.; Turci, Luiz F. R.; Winter, Othon C.

    2011-03-01

    number of attendees ever. Finally, we would like to express our gratitude to all the participants for their presentations, discussions, and remarkable interactions with one another. The tireless work undertaken by all the members of the International Advisory Committee and the Organizing Committee must also be recognized. We also wish to express our deep appreciation for the Scientific Societies and Research Support Agencies which supported the conference and provided all the resources which were necessary to make this idea of a South American Dynamics Days come true. Elbert E N Macau, Tiago Pereira, Antonio F B A Prado, Luiz F R Turci, and Othon C WinterEditors Conference photograph Conference photograph Conference photograph Conference photograph International Advisory Committee Adilson E MotterNorthwestern UniversityEvanston - IL - USA Alfredo OzorioCentro Brasileiro de Pesquisas FísicasRio de Janeiro - RJ - Brazil Celso Grebogi (Chair)University of AberdeenAberdeen - UK Ed OttUniversity of MarylandCollege Park - MD - USA Epaminondas Rosa JrIllinois State UniversityNormal - IL - USA Hans Ingo WeberPontifícia Universidade CatólicaRio de Janeiro - RJ - Brazil Holger KantzMax Planck Institute for the Physics of Complex SystemsDresden - Germany Jason Gallas (Co-chair)Universidade Federal do Rio Grande do SulPorto Alegre - RS - Brazil José Roberto Rios LeiteUniv. Federal de PernanbucoRecife - PE - Brazil Jürgen KurthsPotsdam Institute for climate Impact ResearchHumboldt University, Berlin - Germany Kenneth ShowalterWest Virginia UniversityMorgantown - WV - USA Lou PecoraNaval Research LabWashington - DC - USA Luis Antonio AguirreUniversidade Federal de Minas GeraisBelo Horizonte - MG - Brazil Marcelo VianaIMPA - Instituto Nacional de Matemática Pura e AplicadaRio de Janeiro - RJ - Brazil Miguel A F SanjuánUniversidad Rey Juan CarlosMadrid - Spain Paulo Roberto de Souza MendesPontifícia Universidade CatólicaRio de Janeiro - RJ - Brazil Roland KorbeleUniversidade de

  12. Chronic kidney disease and associated risk factors in the Bajo Lempa region of El Salvador: Nefrolempa study, 2009.

    PubMed

    Orantes, Carlos M; Herrera, Raúl; Almaguer, Miguel; Brizuela, Elsy G; Hernández, Carlos E; Bayarre, Héctor; Amaya, Juan C; Calero, Denis J; Orellana, Patricia; Colindres, Rosa M; Velázquez, María E; Núñez, Sonia G; Contreras, Verónica M; Castro, Bertha E

    2011-10-01

    INTRODUCCIÓN En El Salvador, la enfermedad renal crónica terminal es la causa principal de muerte hospitalaria en adultos, la segunda causa de muerte en los hombres y la quinta causa principal de muerte entre adultos de ambos sexos en la población general. OBJETIVO Identificar los factores de riesgo de la enfermedad renal crónica y los marcadores de daño renovascular en orina, medir la función renal y caracterizar la prevalencia de enfermedad renal crónica en personas X18 años de edad en la región del Bajo Lempa en El Salvador. METODOS Se realizó un estudio epidemiológico transversal y analítico de la enfermedad renal crónica y los factores de riesgo asociados en individuos con edades X18 años por medio de pesquisa activa en la Región del Bajo Lempa, una zona costera rural en El Salvador. Se efectuaron visitas casa por casa y consultas médicas. Se recolectaron datos epidemiológicos y clínicos que incluían: historia clínica personal y familiar para la enfermedad; factores de riesgo biológicos, de conducta, sociales y ambientales; mediciones físicas; análisis de orina buscando marcadores de daño renovascular y exámenes de sangre (creatinina y glucosa en suero, lipidograma). La tasa de filtración glomerular se calculó usando la fórmula de MDRD (sigla en inglés de Modificación de la Dieta en la Enfermedad Renal). La confirmación de casos de enfermedad renal crónica se realizó en un período de tres meses. Se utilizó la regresión logística múltiple para analizar los datos. RESULTADOS Se estudiaron un total de 375 familias y 775 individuos (343 hombres, 432 mujeres), el 88,3% del total de la población residente en la región. Se observó una elevada prevalencia de factores de riesgo: diabetes mellitus en 10,3%; hipertensión en 16,9%; antecedentes familiares de enfermedad renal crónica en 21,6%; dislipidemias en 63,1%; sobrepeso en 34%; obesidad en 22,4%; síndrome metabólico en 28,8%; uso de medicamentos anti-inZ amatorios no

  13. What are the main environmental exposures associated with elevated IgE in Cuban infants? A population-based study

    PubMed Central

    Fundora-Hernández, Hermes; Venero-Fernández, Silvia J; Suárez-Medina, Ramón; Mora-Faife, Esperanza de la C; García-García, Gladys; del Valle-Infante, Ileana; Gómez-Marrero, Liem; Venn, Andrea; Britton, John; Fogarty, Andrew W

    2014-01-01

    unos niveles altos de IgE en los niños. El objetivo de este estudio era determinar los factores de riesgo de unos niveles elevados de IgE en sueros de niños viviendo en La Habana. Métodos Se obtuvieron muestras de sangre de 877 niños. Se recolectaron datos sobre los síntomas de la alergia y un amplio rango de exposiciones. Resultados La mediana de IgE era de 35 IU/ml (rango intercuartil 13–96). El riesgo de tener unos niveles altos de IgE, por encima de la mediana, era mayor en niños que habían sido amamantados durante cuatro meses o más (odds ratio (OR) ajustado 1.28; intervalo de confianza (IC) 95%: 1.02–1.61) y en niños para los que se había reportado presencia de cucarachas en sus hogares (OR 1.30; 95% CI: 1.03–1.63). El riesgo era menor para niños cuya madre tenía un empleo pagado (OR 0.73; IC 95%: 0.54–0.97 comparado con aquellos que no la tenían), para niños viviendo en hogares en los que se utilizaba gas y electricidad para cocinar (OR 0.45; IC 95%: 0.32–0.62 comparado con electricidad solamente) y para niños con mascotas domésticas en el momento de nacer (OR 0.83; IC 95%: 0.70–1.00). No existía una asociación entre el uso del paracetamol y los niveles de IgE en suero. Conclusiones Las asociaciones con el uso de gas como combustible y el empleo de la madre indican que los niveles de IgE en una etapa temprana de la vida son menores en niños viviendo con un cierto nivel de opulencia. Las discrepancias en el efecto de una exposición temprana a mascotas o cucarachas podría reflejar las diferencias en estos alergenos, aunque la relativa opulencia podría jugar como factor de confusión. Nuevos estudios con esta cohorte podrían determinar cómo estos efectos se traducen en la expresión de la enfermedad alérgica más adelante en la vida. PMID:24674274