Kalman filter to update forest cover estimates

Treesearch

Raymond L. Czaplewski

1990-01-01

The Kalman filter is a statistical estimator that combines a time-series of independent estimates, using a prediction model that describes expected changes in the state of a system over time. An expensive inventory can be updated using model predictions that are adjusted with more recent, but less expensive and precise, monitoring data. The concepts of the Kalman...

On the use of programmable hardware and reduced numerical precision in earth-system modeling.

PubMed

Düben, Peter D; Russell, Francis P; Niu, Xinyu; Luk, Wayne; Palmer, T N

2015-09-01

Programmable hardware, in particular Field Programmable Gate Arrays (FPGAs), promises a significant increase in computational performance for simulations in geophysical fluid dynamics compared with CPUs of similar power consumption. FPGAs allow adjusting the representation of floating-point numbers to specific application needs. We analyze the performance-precision trade-off on FPGA hardware for the two-scale Lorenz '95 model. We scale the size of this toy model to that of a high-performance computing application in order to make meaningful performance tests. We identify the minimal level of precision at which changes in model results are not significant compared with a maximal precision version of the model and find that this level is very similar for cases where the model is integrated for very short or long intervals. It is therefore a useful approach to investigate model errors due to rounding errors for very short simulations (e.g., 50 time steps) to obtain a range for the level of precision that can be used in expensive long-term simulations. We also show that an approach to reduce precision with increasing forecast time, when model errors are already accumulated, is very promising. We show that a speed-up of 1.9 times is possible in comparison to FPGA simulations in single precision if precision is reduced with no strong change in model error. The single-precision FPGA setup shows a speed-up of 2.8 times in comparison to our model implementation on two 6-core CPUs for large model setups.

DFB laser array driver circuit controlled by adjustable signal

NASA Astrophysics Data System (ADS)

Du, Weikang; Du, Yinchao; Guo, Yu; Li, Wei; Wang, Hao

2018-01-01

In order to achieve the intelligent controlling of DFB laser array, this paper presents the design of an intelligence and high precision numerical controlling electric circuit. The system takes MCU and FPGA as the main control chip, with compact, high-efficiency, no impact, switching protection characteristics. The output of the DFB laser array can be determined by an external adjustable signal. The system transforms the analog control model into a digital control model, which improves the performance of the driver. The system can monitor the temperature and current of DFB laser array in real time. The output precision of the current can reach ± 0.1mA, which ensures the stable and reliable operation of the DFB laser array. Such a driver can benefit the flexible usage of the DFB laser array.

Platform Precision Autopilot Overview and Mission Performance

NASA Technical Reports Server (NTRS)

Strovers, Brian K.; Lee, James A.

2009-01-01

The Platform Precision Autopilot is an instrument landing system-interfaced autopilot system, developed to enable an aircraft to repeatedly fly nearly the same trajectory hours, days, or weeks later. The Platform Precision Autopilot uses a novel design to interface with a NASA Gulfstream III jet by imitating the output of an instrument landing system approach. This technique minimizes, as much as possible, modifications to the baseline Gulfstream III jet and retains the safety features of the aircraft autopilot. The Platform Precision Autopilot requirement is to fly within a 5-m (16.4-ft) radius tube for distances to 200 km (108 nmi) in the presence of light turbulence for at least 90 percent of the time. This capability allows precise repeat-pass interferometry for the Unmanned Aerial Vehicle Synthetic Aperture Radar program, whose primary objective is to develop a miniaturized, polarimetric, L-band synthetic aperture radar. Precise navigation is achieved using an accurate differential global positioning system developed by the Jet Propulsion Laboratory. Flight-testing has demonstrated the ability of the Platform Precision Autopilot to control the aircraft within the specified tolerance greater than 90 percent of the time in the presence of aircraft system noise and nonlinearities, constant pilot throttle adjustments, and light turbulence.

Platform Precision Autopilot Overview and Flight Test Results

NASA Technical Reports Server (NTRS)

Lin, V.; Strovers, B.; Lee, J.; Beck, R.

2008-01-01

The Platform Precision Autopilot is an instrument landing system interfaced autopilot system, developed to enable an aircraft to repeatedly fly nearly the same trajectory hours, days, or weeks later. The Platform Precision Autopilot uses a novel design to interface with a NASA Gulfstream III jet by imitating the output of an instrument landing system approach. This technique minimizes, as much as possible, modifications to the baseline Gulfstream III jet and retains the safety features of the aircraft autopilot. The Platform Precision Autopilot requirement is to fly within a 5-m (16.4-ft) radius tube for distances to 200 km (108 nmi) in the presence of light turbulence for at least 90 percent of the time. This capability allows precise repeat-pass interferometry for the Uninhabited Aerial Vehicle Synthetic Aperture Radar program, whose primary objective is to develop a miniaturized, polarimetric, L-band synthetic aperture radar. Precise navigation is achieved using an accurate differential global positioning system developed by the Jet Propulsion Laboratory. Flight-testing has demonstrated the ability of the Platform Precision Autopilot to control the aircraft within the specified tolerance greater than 90 percent of the time in the presence of aircraft system noise and nonlinearities, constant pilot throttle adjustments, and light turbulence.

Disaggregating soil erosion processes within an evolving experimental landscape

USDA-ARS?s Scientific Manuscript database

Soil-mantled landscapes subjected to rainfall, runoff events, and downstream base level adjustments will erode and evolve in time and space. Yet the precise mechanisms for soil erosion also will vary, and such variations may not be adequately captured by soil erosion prediction technology. This st...

CPU time optimization and precise adjustment of the Geant4 physics parameters for a VARIAN 2100 C/D gamma radiotherapy linear accelerator simulation using GAMOS.

PubMed

Arce, Pedro; Lagares, Juan Ignacio

2018-01-25

We have verified the GAMOS/Geant4 simulation model of a 6 MV VARIAN Clinac 2100 C/D linear accelerator by the procedure of adjusting the initial beam parameters to fit the percentage depth dose and cross-profile dose experimental data at different depths in a water phantom. Thanks to the use of a wide range of field sizes, from 2  ×  2 cm 2 to 40  ×  40 cm 2 , a small phantom voxel size and high statistics, fine precision in the determination of the beam parameters has been achieved. This precision has allowed us to make a thorough study of the different physics models and parameters that Geant4 offers. The three Geant4 electromagnetic physics sets of models, i.e. Standard, Livermore and Penelope, have been compared to the experiment, testing the four different models of angular bremsstrahlung distributions as well as the three available multiple-scattering models, and optimizing the most relevant Geant4 electromagnetic physics parameters. Before the fitting, a comprehensive CPU time optimization has been done, using several of the Geant4 efficiency improvement techniques plus a few more developed in GAMOS.

Design of a self-adaptive fuzzy PID controller for piezoelectric ceramics micro-displacement system

NASA Astrophysics Data System (ADS)

Zhang, Shuang; Zhong, Yuning; Xu, Zhongbao

2008-12-01

In order to improve control precision of the piezoelectric ceramics (PZT) micro-displacement system, a self-adaptive fuzzy Proportional Integration Differential (PID) controller is designed based on the traditional digital PID controller combining with fuzzy control. The arithmetic gives a fuzzy control rule table with the fuzzy control rule and fuzzy reasoning, through this table, the PID parameters can be adjusted online in real time control. Furthermore, the automatic selective control is achieved according to the change of the error. The controller combines the good dynamic capability of the fuzzy control and the high stable precision of the PID control, adopts the method of using fuzzy control and PID control in different segments of time. In the initial and middle stage of the transition process of system, that is, when the error is larger than the value, fuzzy control is used to adjust control variable. It makes full use of the fast response of the fuzzy control. And when the error is smaller than the value, the system is about to be in the steady state, PID control is adopted to eliminate static error. The problems of PZT existing in the field of precise positioning are overcome. The results of the experiments prove that the project is correct and practicable.

Accurate time delay technology in simulated test for high precision laser range finder

NASA Astrophysics Data System (ADS)

Chen, Zhibin; Xiao, Wenjian; Wang, Weiming; Xue, Mingxi

2015-10-01

With the continuous development of technology, the ranging accuracy of pulsed laser range finder (LRF) is higher and higher, so the maintenance demand of LRF is also rising. According to the dominant ideology of "time analog spatial distance" in simulated test for pulsed range finder, the key of distance simulation precision lies in the adjustable time delay. By analyzing and comparing the advantages and disadvantages of fiber and circuit delay, a method was proposed to improve the accuracy of the circuit delay without increasing the count frequency of the circuit. A high precision controllable delay circuit was designed by combining the internal delay circuit and external delay circuit which could compensate the delay error in real time. And then the circuit delay accuracy could be increased. The accuracy of the novel circuit delay methods proposed in this paper was actually measured by a high sampling rate oscilloscope actual measurement. The measurement result shows that the accuracy of the distance simulated by the circuit delay is increased from +/- 0.75m up to +/- 0.15m. The accuracy of the simulated distance is greatly improved in simulated test for high precision pulsed range finder.

Precision positioning device

DOEpatents

McInroy, John E.

2005-01-18

A precision positioning device is provided. The precision positioning device comprises a precision measuring/vibration isolation mechanism. A first plate is provided with the precision measuring mean secured to the first plate. A second plate is secured to the first plate. A third plate is secured to the second plate with the first plate being positioned between the second plate and the third plate. A fourth plate is secured to the third plate with the second plate being positioned between the third plate and the fourth plate. An adjusting mechanism for adjusting the position of the first plate, the second plate, the third plate, and the fourth plate relative to each other.

Actual Operation Simulation of RESSOX Ground Experiments

DTIC Science & Technology

2010-11-01

Note 1289,” (Hewlett-Packard), 60 pp. [5] F. Tappero, A. Dempster, T . Iwata, M. Imae, T . Ikegami , Y. Fukuyama, K. Hagimoto, and A. Iwasaki, 2006...Delay Ionospheric Delay Ku-band Delay Estimation Frequency- Independent part Frequency- Dependent part Elapsed Time with Current Time Set as 0 (s) T ...im e t o b e A d ju s te d 0-6-105 Extrapolated with First- Order Least-Squares Filter Time Adjustment Command 42 nd Annual Precise Time and Time

Precision translator

DOEpatents

Reedy, R.P.; Crawford, D.W.

1982-03-09

A precision translator for focusing a beam of light on the end of a glass fiber which includes two turning fork-like members rigidly connected to each other. These members have two prongs each with its separation adjusted by a screw, thereby adjusting the orthogonal positioning of a glass fiber attached to one of the members. This translator is made of simple parts with capability to keep adjustment even in condition of rough handling.

Precision translator

DOEpatents

Reedy, Robert P.; Crawford, Daniel W.

1984-01-01

A precision translator for focusing a beam of light on the end of a glass fiber which includes two turning fork-like members rigidly connected to each other. These members have two prongs each with its separation adjusted by a screw, thereby adjusting the orthogonal positioning of a glass fiber attached to one of the members. This translator is made of simple parts with capability to keep adjustment even in condition of rough handling.

Self-assembled DNA tetrahedral optofluidic lasers with precise and tunable gain control.

PubMed

Chen, Qiushu; Liu, Huajie; Lee, Wonsuk; Sun, Yuze; Zhu, Dan; Pei, Hao; Fan, Chunhai; Fan, Xudong

2013-09-07

We have applied self-assembled DNA tetrahedral nanostructures for the precise and tunable control of the gain in an optofluidic fluorescence resonance energy transfer (FRET) laser. By adjusting the ratio of the donor and the acceptor attached to the tetrahedral vertices, 3.8 times reduction in the lasing threshold and 28-fold enhancement in the lasing efficiency were demonstrated. This work takes advantage of the self-recognition and self-assembly capabilities of biomolecules with well-defined structures and addressability, enabling nano-engineering of the laser down to the molecular level.

Note: Tandem Kirkpatrick-Baez microscope with sixteen channels for high-resolution laser-plasma diagnostics

NASA Astrophysics Data System (ADS)

Yi, Shengzhen; Zhang, Zhe; Huang, Qiushi; Zhang, Zhong; Wang, Zhanshan; Wei, Lai; Liu, Dongxiao; Cao, Leifeng; Gu, Yuqiu

2018-03-01

Multi-channel Kirkpatrick-Baez (KB) microscopes, which have better resolution and collection efficiency than pinhole cameras, have been widely used in laser inertial confinement fusion to diagnose time evolution of the target implosion. In this study, a tandem multi-channel KB microscope was developed to have sixteen imaging channels with the precise control of spatial resolution and image intervals. This precise control was created using a coarse assembly of mirror pairs with high-accuracy optical prisms, followed by precise adjustment in real-time x-ray imaging experiments. The multilayers coated on the KB mirrors were designed to have substantially the same reflectivity to obtain a uniform brightness of different images for laser-plasma temperature analysis. The study provides a practicable method to achieve the optimum performance of the microscope for future high-resolution applications in inertial confinement fusion experiments.

On the precision of automated activation time estimation

NASA Technical Reports Server (NTRS)

Kaplan, D. T.; Smith, J. M.; Rosenbaum, D. S.; Cohen, R. J.

1988-01-01

We examined how the assignment of local activation times in epicardial and endocardial electrograms is affected by sampling rate, ambient signal-to-noise ratio, and sinx/x waveform interpolation. Algorithms used for the estimation of fiducial point locations included dV/dtmax, and a matched filter detection algorithm. Test signals included epicardial and endocardial electrograms overlying both normal and infarcted regions of dog myocardium. Signal-to-noise levels were adjusted by combining known data sets with white noise "colored" to match the spectral characteristics of experimentally recorded noise. For typical signal-to-noise ratios and sampling rates, the template-matching algorithm provided the greatest precision in reproducibly estimating fiducial point location, and sinx/x interpolation allowed for an additional significant improvement. With few restrictions, combining these two techniques may allow for use of digitization rates below the Nyquist rate without significant loss of precision.

Self-Calibrated In-Process Photogrammetry for Large Raw Part Measurement and Alignment before Machining

PubMed Central

Mendikute, Alberto; Zatarain, Mikel; Bertelsen, Álvaro; Leizea, Ibai

2017-01-01

Photogrammetry methods are being used more and more as a 3D technique for large scale metrology applications in industry. Optical targets are placed on an object and images are taken around it, where measuring traceability is provided by precise off-process pre-calibrated digital cameras and scale bars. According to the 2D target image coordinates, target 3D coordinates and camera views are jointly computed. One of the applications of photogrammetry is the measurement of raw part surfaces prior to its machining. For this application, post-process bundle adjustment has usually been adopted for computing the 3D scene. With that approach, a high computation time is observed, leading in practice to time consuming and user dependent iterative review and re-processing procedures until an adequate set of images is taken, limiting its potential for fast, easy-to-use, and precise measurements. In this paper, a new efficient procedure is presented for solving the bundle adjustment problem in portable photogrammetry. In-process bundle computing capability is demonstrated on a consumer grade desktop PC, enabling quasi real time 2D image and 3D scene computing. Additionally, a method for the self-calibration of camera and lens distortion has been integrated into the in-process approach due to its potential for highest precision when using low cost non-specialized digital cameras. Measurement traceability is set only by scale bars available in the measuring scene, avoiding the uncertainty contribution of off-process camera calibration procedures or the use of special purpose calibration artifacts. The developed self-calibrated in-process photogrammetry has been evaluated both in a pilot case scenario and in industrial scenarios for raw part measurement, showing a total in-process computing time typically below 1 s per image up to a maximum of 2 s during the last stages of the computed industrial scenes, along with a relative precision of 1/10,000 (e.g., 0.1 mm error in 1 m) with an error RMS below 0.2 pixels at image plane, ranging at the same performance reported for portable photogrammetry with precise off-process pre-calibrated cameras. PMID:28891946

Self-Calibrated In-Process Photogrammetry for Large Raw Part Measurement and Alignment before Machining.

PubMed

Mendikute, Alberto; Yagüe-Fabra, José A; Zatarain, Mikel; Bertelsen, Álvaro; Leizea, Ibai

2017-09-09

Photogrammetry methods are being used more and more as a 3D technique for large scale metrology applications in industry. Optical targets are placed on an object and images are taken around it, where measuring traceability is provided by precise off-process pre-calibrated digital cameras and scale bars. According to the 2D target image coordinates, target 3D coordinates and camera views are jointly computed. One of the applications of photogrammetry is the measurement of raw part surfaces prior to its machining. For this application, post-process bundle adjustment has usually been adopted for computing the 3D scene. With that approach, a high computation time is observed, leading in practice to time consuming and user dependent iterative review and re-processing procedures until an adequate set of images is taken, limiting its potential for fast, easy-to-use, and precise measurements. In this paper, a new efficient procedure is presented for solving the bundle adjustment problem in portable photogrammetry. In-process bundle computing capability is demonstrated on a consumer grade desktop PC, enabling quasi real time 2D image and 3D scene computing. Additionally, a method for the self-calibration of camera and lens distortion has been integrated into the in-process approach due to its potential for highest precision when using low cost non-specialized digital cameras. Measurement traceability is set only by scale bars available in the measuring scene, avoiding the uncertainty contribution of off-process camera calibration procedures or the use of special purpose calibration artifacts. The developed self-calibrated in-process photogrammetry has been evaluated both in a pilot case scenario and in industrial scenarios for raw part measurement, showing a total in-process computing time typically below 1 s per image up to a maximum of 2 s during the last stages of the computed industrial scenes, along with a relative precision of 1/10,000 (e.g. 0.1 mm error in 1 m) with an error RMS below 0.2 pixels at image plane, ranging at the same performance reported for portable photogrammetry with precise off-process pre-calibrated cameras.

Research on the Diesel Engine with Sliding Mode Variable Structure Theory

NASA Astrophysics Data System (ADS)

Ma, Zhexuan; Mao, Xiaobing; Cai, Le

2018-05-01

This study constructed the nonlinear mathematical model of the diesel engine high-pressure common rail (HPCR) system through two polynomial fitting which was treated as a kind of affine nonlinear system. Based on sliding-mode variable structure control (SMVSC) theory, a sliding-mode controller for affine nonlinear systems was designed for achieving the control of common rail pressure and the diesel engine’s rotational speed. Finally, on the simulation platform of MATLAB, the designed nonlinear HPCR system was simulated. The simulation results demonstrated that sliding-mode variable structure control algorithm shows favourable control performances which are overcoming the shortcomings of traditional PID control in overshoot, parameter adjustment, system precision, adjustment time and ascending time.

Method and apparatus for controlling fluid flow

DOEpatents

Miller, J.R.

1980-06-27

A method and apparatus for precisely controlling the rate (and hence amount) of fluid flow are given. The controlled flow rate is finely adjustable, can be extremely small (on the order of microliter-atmospheres per second), can be adjusted to zero (flow stopped), and is stable to better than 1% with time. The dead volume of the valve can be made arbitrarily small, in fact essentially zero. The valve employs no wearing mechanical parts (including springs, stems, or seals). The valve is finely adjustable, has a flow rate dynamic range of many decades, can be made compatible with any fluid, and is suitable for incorporation into an open or closed loop servo-control system.

Towards the GEOSAT Follow-On Precise Orbit Determination Goals of High Accuracy and Near-Real-Time Processing

NASA Technical Reports Server (NTRS)

Lemoine, Frank G.; Zelensky, Nikita P.; Chinn, Douglas S.; Beckley, Brian D.; Lillibridge, John L.

2006-01-01

The US Navy's GEOSAT Follow-On spacecraft (GFO) primary mission objective is to map the oceans using a radar altimeter. Satellite laser ranging data, especially in combination with altimeter crossover data, offer the only means of determining high-quality precise orbits. Two tuned gravity models, PGS7727 and PGS7777b, were created at NASA GSFC for GFO that reduce the predicted radial orbit through degree 70 to 13.7 and 10.0 mm. A macromodel was developed to model the nonconservative forces and the SLR spacecraft measurement offset was adjusted to remove a mean bias. Using these improved models, satellite-ranging data, altimeter crossover data, and Doppler data are used to compute both daily medium precision orbits with a latency of less than 24 hours. Final precise orbits are also computed using these tracking data and exported with a latency of three to four weeks to NOAA for use on the GFO Geophysical Data Records (GDR s). The estimated orbit precision of the daily orbits is between 10 and 20 cm, whereas the precise orbits have a precision of 5 cm.

An injection seeded single frequency Nd:YAG Q-switched laser with precisely controllable laser pulse firing time

NASA Astrophysics Data System (ADS)

Wu, Frank F.; Khizhnyak, Anatoliy; Markov, Vladimir

2010-02-01

We have realized a single frequency Q-switched Nd:YAG laser with precisely controllable lasing time and thus enabled synchronization of multi-laser systems. The use of injection seeding to the slave ring oscillator results in unidirectional Q-switched laser oscillation with suppression of bidirectional Q-switched oscillation that otherwise would be initiated from spontaneous emission if the seeding laser is not present. Under normal condition, the cavity is high in loss during the pumping period; then a Pockels cell opens the cavity to form the pulse build up, with a second Pockels cell to perform cavity dumping, generating the Q-switched pulse output with optimized characteristics. The two Pockels cells can be replaced by a single unit if an adjustable gated electrical pulse is applied to the Pockels cell in which the pulse front is used to open the cavity and the falling edge to dump the laser pulse. Proper selection of the pump parameters and Pockels-cell gating enables operation of the system in a mode in which the Q-switched pulse can be formed only under the seeding condition. The advantage of the realized regime is in stable laser operation with no need in adjustment of the seeded light wavelength and the mode of the cavity. It is found that the frequency of the Q-switched laser radiation matches well to the injected seeded laser mode. By using two-stage amplifiers, an output energy better than 300 mJ has been achieved in MOPA configuration without active control of the cavity length and with pulse width adjustability from several nanoseconds to 20 ns. The Q-switched oscillator operates not only at precisely controlled firing time but also can be tuned over wide range. This will enable multi-laser systems synchronization and frequency locking down each other if necessary.

A precise clock distribution network for MRPC-based experiments

NASA Astrophysics Data System (ADS)

Wang, S.; Cao, P.; Shang, L.; An, Q.

2016-06-01

In high energy physics experiments, the MRPC (Multi-Gap Resistive Plate Chamber) detectors are widely used recently which can provide higher-resolution measurement for particle identification. However, the application of MRPC detectors leads to a series of challenges in electronics design with large number of front-end electronic channels, especially for distributing clock precisely. To deal with these challenges, this paper presents a universal scheme of clock transmission network for MRPC-based experiments with advantages of both precise clock distribution and global command synchronization. For precise clock distributing, the clock network is designed into a tree architecture with two stages: the first one has a point-to-multipoint long range bidirectional distribution with optical channels and the second one has a fan-out structure with copper link inside readout crates. To guarantee the precision of clock frequency or phase, the r-PTP (reduced Precision Time Protocol) and the DDMTD (digital Dual Mixer Time Difference) methods are used for frequency synthesis, phase measurement and adjustment, which is implemented by FPGA (Field Programmable Gate Array) in real-time. In addition, to synchronize global command execution, based upon this clock distribution network, synchronous signals are coded with clock for transmission. With technique of encoding/decoding and clock data recovery, signals such as global triggers or system control commands, can be distributed to all front-end channels synchronously, which greatly simplifies the system design. The experimental results show that both the clock jitter (RMS) and the clock skew can be less than 100 ps.

Apparatus and method for compensating for clock drift in downhole drilling components

DOEpatents

Hall, David R [Provo, UT; Pixton, David S [Lehi, UT; Johnson, Monte L [Orem, UT; Bartholomew, David B [Springville, UT; Hall, Jr., H. Tracy

2007-08-07

A precise downhole clock that compensates for drift includes a prescaler configured to receive electrical pulses from an oscillator. The prescaler is configured to output a series of clock pulses. The prescaler outputs each clock pulse after counting a preloaded number of electrical pulses from the oscillator. The prescaler is operably connected to a compensator module for adjusting the number loaded into the prescaler. By adjusting the number that is loaded into the prescaler, the timing may be advanced or retarded to more accurately synchronize the clock pulses with a reference time source. The compensator module is controlled by a counter-based trigger module configured to trigger the compensator module to load a value into the prescaler. Finally, a time-base logic module is configured to calculate the drift of the downhole clock by comparing the time of the downhole clock with a reference time source.

Quantum metrology and estimation of Unruh effect

PubMed Central

Wang, Jieci; Tian, Zehua; Jing, Jiliang; Fan, Heng

2014-01-01

We study the quantum metrology for a pair of entangled Unruh-Dewitt detectors when one of them is accelerated and coupled to a massless scalar field. Comparing with previous schemes, our model requires only local interaction and avoids the use of cavities in the probe state preparation process. We show that the probe state preparation and the interaction between the accelerated detector and the external field have significant effects on the value of quantum Fisher information, correspondingly pose variable ultimate limit of precision in the estimation of Unruh effect. We find that the precision of the estimation can be improved by a larger effective coupling strength and a longer interaction time. Alternatively, the energy gap of the detector has a range that can provide us a better precision. Thus we may adjust those parameters and attain a higher precision in the estimation. We also find that an extremely high acceleration is not required in the quantum metrology process. PMID:25424772

Highly multiplexed targeted proteomics using precise control of peptide retention time.

PubMed

Gallien, Sebastien; Peterman, Scott; Kiyonami, Reiko; Souady, Jamal; Duriez, Elodie; Schoen, Alan; Domon, Bruno

2012-04-01

Large-scale proteomics applications using SRM analysis on triple quadrupole mass spectrometers present new challenges to LC-MS/MS experimental design. Despite the automation of building large-scale LC-SRM methods, the increased numbers of targeted peptides can compromise the balance between sensitivity and selectivity. To facilitate large target numbers, time-scheduled SRM transition acquisition is performed. Previously published results have demonstrated incorporation of a well-characterized set of synthetic peptides enabled chromatographic characterization of the elution profile for most endogenous peptides. We have extended this application of peptide trainer kits to not only build SRM methods but to facilitate real-time elution profile characterization that enables automated adjustment of the scheduled detection windows. Incorporation of dynamic retention time adjustments better facilitate targeted assays lasting several days without the need for constant supervision. This paper provides an overview of how the dynamic retention correction approach identifies and corrects for commonly observed LC variations. This adjustment dramatically improves robustness in targeted discovery experiments as well as routine quantification experiments. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Digital cross-mounting: A new opportunity in prosthetic dentistry.

PubMed

Venezia, Pietro; Torsello, Ferruccio; D'Amato, Salvatore; Cavalcanti, Raffaele

2017-01-01

The prosthodontic management of complex rehabilitations requires several stages of treatment including one or more provisional restorations. The design and adjustments of the provisional are made to achieve an optimal functional and esthetic outcome for the patient. However, the adjustments needed are both time and cost consuming. Therefore, once a satisfactory provisional is made, the information should not be lost during the following stages of treatment. The purpose of this clinical case is to illustrate "digital cross-mounting," a procedure used to precisely transfer information from the provisional to the final fixed rehabilitation in a digital workflow.

Precise orbit determination for NASA's earth observing system using GPS (Global Positioning System)

NASA Technical Reports Server (NTRS)

Williams, B. G.

1988-01-01

An application of a precision orbit determination technique for NASA's Earth Observing System (EOS) using the Global Positioning System (GPS) is described. This technique allows the geometric information from measurements of GPS carrier phase and P-code pseudo-range to be exploited while minimizing requirements for precision dynamical modeling. The method combines geometric and dynamic information to determine the spacecraft trajectory; the weight on the dynamic information is controlled by adjusting fictitious spacecraft accelerations in three dimensions which are treated as first order exponentially time correlated stochastic processes. By varying the time correlation and uncertainty of the stochastic accelerations, the technique can range from purely geometric to purely dynamic. Performance estimates for this technique as applied to the orbit geometry planned for the EOS platforms indicate that decimeter accuracies for EOS orbit position may be obtainable. The sensitivity of the predicted orbit uncertainties to model errors for station locations, nongravitational platform accelerations, and Earth gravity is also presented.

Multichannel heterodyning for wideband interferometry, correlation and signal processing

DOEpatents

Erskine, David J.

1999-01-01

A method of signal processing a high bandwidth signal by coherently subdividing it into many narrow bandwidth channels which are individually processed at lower frequencies in a parallel manner. Autocorrelation and correlations can be performed using reference frequencies which may drift slowly with time, reducing cost of device. Coordinated adjustment of channel phases alters temporal and spectral behavior of net signal process more precisely than a channel used individually. This is a method of implementing precision long coherent delays, interferometers, and filters for high bandwidth optical or microwave signals using low bandwidth electronics. High bandwidth signals can be recorded, mathematically manipulated, and synthesized.

Multichannel heterodyning for wideband interferometry, correlation and signal processing

DOEpatents

Erskine, D.J.

1999-08-24

A method is disclosed of signal processing a high bandwidth signal by coherently subdividing it into many narrow bandwidth channels which are individually processed at lower frequencies in a parallel manner. Autocorrelation and correlations can be performed using reference frequencies which may drift slowly with time, reducing cost of device. Coordinated adjustment of channel phases alters temporal and spectral behavior of net signal process more precisely than a channel used individually. This is a method of implementing precision long coherent delays, interferometers, and filters for high bandwidth optical or microwave signals using low bandwidth electronics. High bandwidth signals can be recorded, mathematically manipulated, and synthesized. 50 figs.

Analysis of Longitudinal Studies With Repeated Outcome Measures: Adjusting for Time-Dependent Confounding Using Conventional Methods.

PubMed

Keogh, Ruth H; Daniel, Rhian M; VanderWeele, Tyler J; Vansteelandt, Stijn

2018-05-01

Estimation of causal effects of time-varying exposures using longitudinal data is a common problem in epidemiology. When there are time-varying confounders, which may include past outcomes, affected by prior exposure, standard regression methods can lead to bias. Methods such as inverse probability weighted estimation of marginal structural models have been developed to address this problem. However, in this paper we show how standard regression methods can be used, even in the presence of time-dependent confounding, to estimate the total effect of an exposure on a subsequent outcome by controlling appropriately for prior exposures, outcomes, and time-varying covariates. We refer to the resulting estimation approach as sequential conditional mean models (SCMMs), which can be fitted using generalized estimating equations. We outline this approach and describe how including propensity score adjustment is advantageous. We compare the causal effects being estimated using SCMMs and marginal structural models, and we compare the two approaches using simulations. SCMMs enable more precise inferences, with greater robustness against model misspecification via propensity score adjustment, and easily accommodate continuous exposures and interactions. A new test for direct effects of past exposures on a subsequent outcome is described.

Baseline adjustments for binary data in repeated cross-sectional cluster randomized trials.

PubMed

Nixon, R M; Thompson, S G

2003-09-15

Analysis of covariance models, which adjust for a baseline covariate, are often used to compare treatment groups in a controlled trial in which individuals are randomized. Such analysis adjusts for any baseline imbalance and usually increases the precision of the treatment effect estimate. We assess the value of such adjustments in the context of a cluster randomized trial with repeated cross-sectional design and a binary outcome. In such a design, a new sample of individuals is taken from the clusters at each measurement occasion, so that baseline adjustment has to be at the cluster level. Logistic regression models are used to analyse the data, with cluster level random effects to allow for different outcome probabilities in each cluster. We compare the estimated treatment effect and its precision in models that incorporate a covariate measuring the cluster level probabilities at baseline and those that do not. In two data sets, taken from a cluster randomized trial in the treatment of menorrhagia, the value of baseline adjustment is only evident when the number of subjects per cluster is large. We assess the generalizability of these findings by undertaking a simulation study, and find that increased precision of the treatment effect requires both large cluster sizes and substantial heterogeneity between clusters at baseline, but baseline imbalance arising by chance in a randomized study can always be effectively adjusted for. Copyright 2003 John Wiley & Sons, Ltd.

Investigation on the Nonlinear Control System of High-Pressure Common Rail (HPCR) System in a Diesel Engine

NASA Astrophysics Data System (ADS)

Cai, Le; Mao, Xiaobing; Ma, Zhexuan

2018-02-01

This study first constructed the nonlinear mathematical model of the high-pressure common rail (HPCR) system in the diesel engine. Then, the nonlinear state transformation was performed using the flow’s calculation and the standard state space equation was acquired. Based on sliding-mode variable structure control (SMVSC) theory, a sliding-mode controller for nonlinear systems was designed for achieving the control of common rail pressure and the diesel engine’s rotational speed. Finally, on the simulation platform of MATLAB, the designed nonlinear HPCR system was simulated. The simulation results demonstrate that sliding-mode variable structure control algorithm shows favorable control performances and overcome the shortcomings of traditional PID control in overshoot, parameter adjustment, system precision, adjustment time and ascending time.

Space Technology 7 Disturbance Reduction System - precision control flight Validation

NASA Technical Reports Server (NTRS)

Carmain, Andrew J.; Dunn, Charles; Folkner, William; Hruby, Vlad; Spence, Doug; O'Donnell, James; Markley, Landis; Maghami, Peiman; Hsu, Oscar; Demmons, N.;

Tooling Converts Stock Bearings To Custom Bearings

NASA Technical Reports Server (NTRS)

Fleenor, E. N., Jr.

1983-01-01

Technique for reworking stock bearings saves time and produces helicopter-rotor bearings ground more precisely. Split tapered ring at one end of threaded bolt expands to hold inside of inner race bearing assembly; nut, at other end of bolt, adjusts amount of spring tension. Piece of hardware grasps bearing firmly without interfering with grinding operation. Operation produces bearing of higher quality than commercially available bearings.

Method of Individual Adjustment for 3D CT Analysis: Linear Measurement.

PubMed

Kim, Dong Kyu; Choi, Dong Hun; Lee, Jeong Woo; Yang, Jung Dug; Chung, Ho Yun; Cho, Byung Chae; Choi, Kang Young

2016-01-01

Introduction . We aim to regularize measurement values in three-dimensional (3D) computed tomography (CT) reconstructed images for higher-precision 3D analysis, focusing on length-based 3D cephalometric examinations. Methods . We measure the linear distances between points on different skull models using Vernier calipers (real values). We use 10 differently tilted CT scans for 3D CT reconstruction of the models and measure the same linear distances from the picture archiving and communication system (PACS). In both cases, each measurement is performed three times by three doctors, yielding nine measurements. The real values are compared with the PACS values. Each PACS measurement is revised based on the display field of view (DFOV) values and compared with the real values. Results . The real values and the PACS measurement changes according to tilt value have no significant correlations ( p > 0.05). However, significant correlations appear between the real values and DFOV-adjusted PACS measurements ( p < 0.001). Hence, we obtain a correlation expression that can yield real physical values from PACS measurements. The DFOV value intervals for various age groups are also verified. Conclusion . Precise confirmation of individual preoperative length and precise analysis of postoperative improvements through 3D analysis is possible, which is helpful for facial-bone-surgery symmetry correction.

Inverse probability weighting for covariate adjustment in randomized studies

PubMed Central

Li, Xiaochun; Li, Lingling

2013-01-01

SUMMARY Covariate adjustment in randomized clinical trials has the potential benefit of precision gain. It also has the potential pitfall of reduced objectivity as it opens the possibility of selecting “favorable” model that yields strong treatment benefit estimate. Although there is a large volume of statistical literature targeting on the first aspect, realistic solutions to enforce objective inference and improve precision are rare. As a typical randomized trial needs to accommodate many implementation issues beyond statistical considerations, maintaining the objectivity is at least as important as precision gain if not more, particularly from the perspective of the regulatory agencies. In this article, we propose a two-stage estimation procedure based on inverse probability weighting to achieve better precision without compromising objectivity. The procedure is designed in a way such that the covariate adjustment is performed before seeing the outcome, effectively reducing the possibility of selecting a “favorable” model that yields a strong intervention effect. Both theoretical and numerical properties of the estimation procedure are presented. Application of the proposed method to a real data example is presented. PMID:24038458

Inverse probability weighting for covariate adjustment in randomized studies.

PubMed

Shen, Changyu; Li, Xiaochun; Li, Lingling

2014-02-20

Covariate adjustment in randomized clinical trials has the potential benefit of precision gain. It also has the potential pitfall of reduced objectivity as it opens the possibility of selecting a 'favorable' model that yields strong treatment benefit estimate. Although there is a large volume of statistical literature targeting on the first aspect, realistic solutions to enforce objective inference and improve precision are rare. As a typical randomized trial needs to accommodate many implementation issues beyond statistical considerations, maintaining the objectivity is at least as important as precision gain if not more, particularly from the perspective of the regulatory agencies. In this article, we propose a two-stage estimation procedure based on inverse probability weighting to achieve better precision without compromising objectivity. The procedure is designed in a way such that the covariate adjustment is performed before seeing the outcome, effectively reducing the possibility of selecting a 'favorable' model that yields a strong intervention effect. Both theoretical and numerical properties of the estimation procedure are presented. Application of the proposed method to a real data example is presented. Copyright © 2013 John Wiley & Sons, Ltd.

Covariate Imbalance and Precision in Measuring Treatment Effects

ERIC Educational Resources Information Center

Liu, Xiaofeng Steven

2011-01-01

Covariate adjustment can increase the precision of estimates by removing unexplained variance from the error in randomized experiments, although chance covariate imbalance tends to counteract the improvement in precision. The author develops an easy measure to examine chance covariate imbalance in randomization by standardizing the average…

Jig For Stereoscopic Photography

NASA Technical Reports Server (NTRS)

Nielsen, David J.

1990-01-01

Separations between views adjusted precisely for best results. Simple jig adjusted to set precisely, distance between right and left positions of camera used to make stereoscopic photographs. Camera slides in slot between extreme positions, where it takes stereoscopic pictures. Distance between extreme positions set reproducibly with micrometer. In view of trend toward very-large-scale integration of electronic circuits, training method and jig used to make training photographs useful to many companies to reduce cost of training manufacturing personnel.

Post implantation adjustable intraocular lenses.

PubMed

Schwartz, D M; Jethmalani, J M; Sandstedt, C A; Kornfield, J A; Grubbs, R H

2001-06-01

To eliminate persistent refractive errors after cataract and phakic IOL surgery, photosensitive silicone IOLs have been developed. These IOL formulations enable precise laser adjustment of IOL power to correct spherical and toric errors post-operatively, after wound and IOL stabilization. Initial experience with these laser adjustable IOLs indicate excellent biocompatability and adjustability of more than five diopters.

Spatio-temporal conditional inference and hypothesis tests for neural ensemble spiking precision

PubMed Central

Harrison, Matthew T.; Amarasingham, Asohan; Truccolo, Wilson

2014-01-01

The collective dynamics of neural ensembles create complex spike patterns with many spatial and temporal scales. Understanding the statistical structure of these patterns can help resolve fundamental questions about neural computation and neural dynamics. Spatio-temporal conditional inference (STCI) is introduced here as a semiparametric statistical framework for investigating the nature of precise spiking patterns from collections of neurons that is robust to arbitrarily complex and nonstationary coarse spiking dynamics. The main idea is to focus statistical modeling and inference, not on the full distribution of the data, but rather on families of conditional distributions of precise spiking given different types of coarse spiking. The framework is then used to develop families of hypothesis tests for probing the spatio-temporal precision of spiking patterns. Relationships among different conditional distributions are used to improve multiple hypothesis testing adjustments and to design novel Monte Carlo spike resampling algorithms. Of special note are algorithms that can locally jitter spike times while still preserving the instantaneous peri-stimulus time histogram (PSTH) or the instantaneous total spike count from a group of recorded neurons. The framework can also be used to test whether first-order maximum entropy models with possibly random and time-varying parameters can account for observed patterns of spiking. STCI provides a detailed example of the generic principle of conditional inference, which may be applicable in other areas of neurostatistical analysis. PMID:25380339

Tool simplifies machining of pipe ends for precision welding

NASA Technical Reports Server (NTRS)

Matus, S. T.

1969-01-01

Single tool prepares a pipe end for precision welding by simultaneously performing internal machining, end facing, and bevel cutting to specification standards. The machining operation requires only one milling adjustment, can be performed quickly, and produces the high quality pipe-end configurations required to ensure precision-welded joints.

The promise of circulating tumor cells for precision cancer therapy.

PubMed

Hwang, William L; Hwang, Katie L; Miyamoto, David T

2016-12-01

The rapidly growing array of therapeutic options in cancer requires informative biomarkers to guide the rational selection and precision application of appropriate therapies. Circulating biomarkers such as circulating tumor cells have immense potential as noninvasive, serial 'liquid biopsies' that may be more representative of the complete spectrum of a patient's individual malignancy than spatially and temporally restricted tumor biopsies. In this review, we discuss the current state-of-the-art in the isolation and molecular characterization of circulating tumor cells as well as their utility in a wide range of clinical applications such as prognostics, treatment monitoring and identification of novel therapeutic targets and resistance mechanisms to enable real-time adjustments in the clinical management of cancer.

A Flexure-Based Mechanism for Precision Adjustment of National Ignition Facility Target Shrouds in Three Rotational Degrees of Freedom

DOE PAGES

Boehm, K. -J.; Gibson, C. R.; Hollaway, J. R.; ...

2016-09-01

This study presents the design of a flexure-based mount allowing adjustment in three rotational degrees of freedom (DOFs) through high-precision set-screw actuators. The requirements of the application called for small but controlled angular adjustments for mounting a cantilevered beam. The proposed design is based on an array of parallel beams to provide sufficiently high stiffness in the translational directions while allowing angular adjustment through the actuators. A simplified physical model in combination with standard beam theory was applied to estimate the deflection profile and maximum stresses in the beams. A finite element model was built to calculate the stresses andmore » beam profiles for scenarios in which the flexure is simultaneously actuated in more than one DOF.« less

Pull-pull position control of dual motor wire rope transmission.

PubMed

Guo, Quan; Jiao, Zongxia; Yan, Liang; Yu, Qian; Shang, Yaoxing

2016-08-01

Wire rope transmission is very efficient because of the small total moving object mass. The wire rope could only transmit pulling force. Therefore it has to be kept in a tightened state during transmission; in high speed applications the dynamic performance depends on the rope's stiffness, which can be adjusted by the wire rope tension. To improve the system dynamic performance output, this paper proposes a novel pull-pull method based on dual motors connected by wire ropes, for precise, high speed position control applications. The method can regulate target position and wire rope tension simultaneously. Wire ropes remain in a pre-tightening state at all times, which prevents the influence of elasticity and reduces the position tracking error in the changing direction process. Simulations and experiments were conducted; the results indicate that both position precision and superior dynamic performance can be synchronously achieved. The research is relevant to space craft precision pointing instruments.

Study on application of adaptive fuzzy control and neural network in the automatic leveling system

NASA Astrophysics Data System (ADS)

Xu, Xiping; Zhao, Zizhao; Lan, Weiyong; Sha, Lei; Qian, Cheng

2015-04-01

This paper discusses the adaptive fuzzy control and neural network BP algorithm in large flat automatic leveling control system application. The purpose is to develop a measurement system with a flat quick leveling, Make the installation on the leveling system of measurement with tablet, to be able to achieve a level in precision measurement work quickly, improve the efficiency of the precision measurement. This paper focuses on the automatic leveling system analysis based on fuzzy controller, Use of the method of combining fuzzy controller and BP neural network, using BP algorithm improve the experience rules .Construct an adaptive fuzzy control system. Meanwhile the learning rate of the BP algorithm has also been run-rate adjusted to accelerate convergence. The simulation results show that the proposed control method can effectively improve the leveling precision of automatic leveling system and shorten the time of leveling.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keall, Paul J., E-mail: paul.keall@sydney.edu.au; Ng, Jin Aun; Juneja, Prabhjot

Purpose: Kilovoltage intrafraction monitoring (KIM) is a new real-time 3-dimensional image guidance method. Unlike previous real-time image guidance methods, KIM uses a standard linear accelerator without any additional equipment needed. The first prospective clinical trial of KIM is underway for prostate cancer radiation therapy. In this paper we report on the measured motion accuracy and precision using real-time KIM-guided gating. Methods and Materials: Imaging and motion information from the first 200 fractions from 6 patient prostate cancer radiation therapy volumetric modulated arc therapy treatments were analyzed. A 3-mm/5-second action threshold was used to trigger a gating event where the beammore » is paused and the couch position adjusted to realign the prostate to the treatment isocenter. To quantify the in vivo accuracy and precision, KIM was compared with simultaneously acquired kV/MV triangulation for 187 fractions. Results: KIM was successfully used in 197 of 200 fractions. Gating events occurred in 29 fractions (14.5%). In these 29 fractions, the percentage of beam-on time, the prostate displacement was >3 mm from the isocenter position, reduced from 73% without KIM to 24% with KIM-guided gating. Displacements >5 mm were reduced from 16% without KIM to 0% with KIM. The KIM accuracy was measured at <0.3 mm in all 3 dimensions. The KIM precision was <0.6 mm in all 3 dimensions. Conclusions: Clinical implementation of real-time KIM image guidance combined with gating for prostate cancer eliminates large prostate displacements during treatment delivery. Both in vivo KIM accuracy and precision are well below 1 mm.« less

Amplitude Control of Solid-State Modulators for Precision Fast Kicker Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Watson, J A; Anaya, R M; Caporaso, G C

2002-11-15

A solid-state modulator with very fast rise and fall times, pulse width agility, and multi-pulse burst and intra-pulse amplitude adjustment capability for use with high speed electron beam kickers has been designed and tested at LLNL. The modulator uses multiple solid-state modules stacked in an inductive-adder configuration. Amplitude adjustment is provided by controlling individual modules in the adder, and is used to compensate for transverse e-beam motion as well as the dynamic response and beam-induced steering effects associated with the kicker structure. A control algorithm calculates a voltage based on measured e-beam displacement and adjusts the modulator to regulate beammore » centroid position. This paper presents design details of amplitude control along with measured performance data from kicker operation on the ETA-II accelerator at LLNL.« less

Work load, job control and risk of leaving work by sickness certification before delivery, Norway 1989.

PubMed

Strand, K; Wergeland, E; Bjerkedal, T

1997-09-01

Sickness absence in pregnancy has been shown to be associated with strenuous working conditions and parity. So far, few studies have made adjustments for possible interaction and confounding. Such adjustments are needed to more precisely identify targets for preventive measures. We have, therefore, in a representative population of pregnant employees in Norway 1989, computed adjusted odds ratios for leaving work by sickness absence more than three (LSC > 3) and eight (LSC > 8) weeks before delivery according to working conditions identified as risk factors in earlier studies; adjusted for job control, domestic conditions and sickness absence the year prior to pregnancy. The cumulative percentage of LSC > 8 and LSC > 3 was 26.4 and 51.1. Ergonomically strenuous postures and heavy lifting increased the risk of both outcomes. In addition, shift work and hectic work pace increased the risk of LSC > 3. Influence on breaks reduced risk. Only para experienced reduced risk of LSC when working part-time. Sicklisting the year prior to pregnancy had no confounding effect, which suggest that pregnancy represents a new incompatibility with work. Preventive measures should address work postures and heavy lifting, as well as conditions influencing the woman's control with her time.

The theory precision analyse of RFM localization of satellite remote sensing imagery

NASA Astrophysics Data System (ADS)

Zhang, Jianqing; Xv, Biao

2009-11-01

The tradition method of detecting precision of Rational Function Model(RFM) is to make use of a great deal check points, and it calculates mean square error through comparing calculational coordinate with known coordinate. This method is from theory of probability, through a large number of samples to statistic estimate value of mean square error, we can think its estimate value approaches in its true when samples are well enough. This paper is from angle of survey adjustment, take law of propagation of error as the theory basis, and it calculates theory precision of RFM localization. Then take the SPOT5 three array imagery as experiment data, and the result of traditional method and narrated method in the paper are compared, while has confirmed tradition method feasible, and answered its theory precision question from the angle of survey adjustment.

Real-time focus controller for laser welding with fibre optic noninvasive capture of light

NASA Astrophysics Data System (ADS)

Cobo, Adolfo; Bardin, F.; Hand, Duncan P.; Jones, Julian D.; Collin, O.; Aubry, P.; Dubois, Thierry; Hoegstroem, M.; Nylen, P.; Jonsson, P.; Lopez-Higuera, Jose M.

2004-06-01

Laser welding is being introduced in the aerospace industry due to its many advantages over traditional techniques. However, welding of parts with complex shapes requires precise control of the focal point of the laser in order to achieve full penetration over the entire seam. In this paper, we present an improved control system for real-time adjustment of the correct focal position, which is based on the monitoring of the light emitted by the process in two different spectral bands. The reported system has been optimized for use in a real environment: it is robust, compact, easy to operate, able to adjust itself to different welding conditions, materials and laser setups, and includes a direct connection to an external PC. Results from recent field trials on complex aerospace structures are provided.

Reliability and precision of pellet-group counts for estimating landscape-level deer density

Treesearch

David S. deCalesta

2013-01-01

This study provides hitherto unavailable methodology for reliably and precisely estimating deer density within forested landscapes, enabling quantitative rather than qualitative deer management. Reliability and precision of the deer pellet-group technique were evaluated in 1 small and 2 large forested landscapes. Density estimates, adjusted to reflect deer harvest and...

Study on initiative vibration absorbing technology of optics in strong disturbed environment

NASA Astrophysics Data System (ADS)

Jia, Si-nan; Xiong, Mu-di; Zou, Xiao-jie

2007-12-01

Strong disturbed environment is apt to cause irregular vibration, which seriously affects optical collimation. To improve the performance of laser beam, three-point dynamic vibration absorbing method is proposed, and laser beam initiative vibration absorbing system is designed. The maladjustment signal is detected by position sensitive device (PSD), three groups of PZT are driven to adjust optical element in real-time, so the performance of output-beam is improved. The coupling model of the system is presented. Multivariable adaptive closed-loop decoupling arithmetic is used to design three-input-three-output decoupling controller, so that high precision dynamic adjusting is realized. Experiments indicate that the system has good shock absorbing efficiency.

A new type industrial total station based on target automatic collimation

NASA Astrophysics Data System (ADS)

Lao, Dabao; Zhou, Weihu; Ji, Rongyi; Dong, Dengfeng; Xiong, Zhi; Wei, Jiang

2018-01-01

In the case of industrial field measurement, the present measuring instruments work with manual operation and collimation, which give rise to low efficiency for field measurement. In order to solve the problem, a new type industrial total station is presented in this paper. The new instrument can identify and trace cooperative target automatically, in the mean time, coordinate of the target is measured in real time. For realizing the system, key technology including high precision absolutely distance measurement, small high accuracy angle measurement, target automatic collimation with vision, and quick precise controlling should be worked out. After customized system assemblage and adjustment, the new type industrial total station will be established. As the experiments demonstrated, the coordinate accuracy of the instrument is under 15ppm in the distance of 60m, which proved that the measuring system is feasible. The result showed that the total station can satisfy most industrial field measurement requirements.

Automated Gravimetric Calibration to Optimize the Accuracy and Precision of TECAN Freedom EVO Liquid Handler

PubMed Central

Bessemans, Laurent; Jully, Vanessa; de Raikem, Caroline; Albanese, Mathieu; Moniotte, Nicolas; Silversmet, Pascal; Lemoine, Dominique

2016-01-01

High-throughput screening technologies are increasingly integrated into the formulation development process of biopharmaceuticals. The performance of liquid handling systems is dependent on the ability to deliver accurate and precise volumes of specific reagents to ensure process quality. We have developed an automated gravimetric calibration procedure to adjust the accuracy and evaluate the precision of the TECAN Freedom EVO liquid handling system. Volumes from 3 to 900 µL using calibrated syringes and fixed tips were evaluated with various solutions, including aluminum hydroxide and phosphate adjuvants, β-casein, sucrose, sodium chloride, and phosphate-buffered saline. The methodology to set up liquid class pipetting parameters for each solution was to split the process in three steps: (1) screening of predefined liquid class, including different pipetting parameters; (2) adjustment of accuracy parameters based on a calibration curve; and (3) confirmation of the adjustment. The run of appropriate pipetting scripts, data acquisition, and reports until the creation of a new liquid class in EVOware was fully automated. The calibration and confirmation of the robotic system was simple, efficient, and precise and could accelerate data acquisition for a wide range of biopharmaceutical applications. PMID:26905719

Cognitive assessment of mice strains heterozygous for cell-adhesion genes reveals strain-specific alterations in timing.

PubMed

Gallistel, C R; Tucci, Valter; Nolan, Patrick M; Schachner, Melitta; Jakovcevski, Igor; Kheifets, Aaron; Barboza, Luendro

2014-03-05

We used a fully automated system for the behavioural measurement of physiologically meaningful properties of basic mechanisms of cognition to test two strains of heterozygous mutant mice, Bfc (batface) and L1, and their wild-type littermate controls. Both of the target genes are involved in the establishment and maintenance of synapses. We find that the Bfc heterozygotes show reduced precision in their representation of interval duration, whereas the L1 heterozygotes show increased precision. These effects are functionally specific, because many other measures made on the same mice are unaffected, namely: the accuracy of matching temporal investment ratios to income ratios in a matching protocol, the rate of instrumental and classical conditioning, the latency to initiate a cued instrumental response, the trials on task and the impulsivity in a switch paradigm, the accuracy with which mice adjust timed switches to changes in the temporal constraints, the days to acquisition, and mean onset time and onset variability in the circadian anticipation of food availability.

Cognitive assessment of mice strains heterozygous for cell-adhesion genes reveals strain-specific alterations in timing

PubMed Central

Gallistel, C. R.; Tucci, Valter; Nolan, Patrick M.; Schachner, Melitta; Jakovcevski, Igor; Kheifets, Aaron; Barboza, Luendro

2014-01-01

We used a fully automated system for the behavioural measurement of physiologically meaningful properties of basic mechanisms of cognition to test two strains of heterozygous mutant mice, Bfc (batface) and L1, and their wild-type littermate controls. Both of the target genes are involved in the establishment and maintenance of synapses. We find that the Bfc heterozygotes show reduced precision in their representation of interval duration, whereas the L1 heterozygotes show increased precision. These effects are functionally specific, because many other measures made on the same mice are unaffected, namely: the accuracy of matching temporal investment ratios to income ratios in a matching protocol, the rate of instrumental and classical conditioning, the latency to initiate a cued instrumental response, the trials on task and the impulsivity in a switch paradigm, the accuracy with which mice adjust timed switches to changes in the temporal constraints, the days to acquisition, and mean onset time and onset variability in the circadian anticipation of food availability. PMID:24446498

Analysis of disruptive events and precarious situations caused by interaction with neurosurgical microscope.

PubMed

Eivazi, Shahram; Afkari, Hoorieh; Bednarik, Roman; Leinonen, Ville; Tukiainen, Markku; Jääskeläinen, Juha E

2015-07-01

Developments in micro-neurosurgical microscopes have improved operating precision and ensured the quality of outcomes. Using the stereoscopic magnified view, however, necessitates frequent manual adjustments to the microscope during an operation. This article reports on an investigation of the interaction details concerning a state-of-the-art micro-neurosurgical microscope. The video data from detailed observations of neurosurgeons' interaction patterns with the microscope were analysed to examine disruptive events caused by adjusting the microscope. The primary findings show that interruptions caused by adjusting the microscope handgrips and mouth switch prolong the surgery time up to 10%. Surgeons, we observed, avoid interaction with the microscope's controls, settings, and configurations by working at the edge of the view, operating on a non-focused view, and assuming unergonomic body postures. The lack of an automatic method for adjusting the microscope is a major problem that causes interruptions during micro-neurosurgery. From this understanding of disruptive events, we discuss the opportunities and limitations of interactive technologies that aim to reduce the frequency or shorten the duration of interruptions caused by microscope adjustment.

VANDENBERG AFB, CALIF. - A worker in the NASA spacecraft processing facility on North Vandenberg Air Force Base adjust the supports on a solar array panel to be lifted and installed on the Gravity Probe B spacecraft. Installing each array is a 3-day process and includes a functional deployment test. The Gravity Probe B mission is a relativity experiment developed by NASA’s Marshall Space Flight Center, Stanford University and Lockheed Martin. The spacecraft will test two extraordinary predictions of Albert Einstein’s general theory of relativity that he advanced in 1916: the geodetic effect (how space and time are warped by the presence of the Earth) and frame dragging (how Earth’s rotation drags space and time around with it). Gravity Probe B consists of four sophisticated gyroscopes that will provide an almost perfect space-time reference system. The mission will look in a precision manner for tiny changes in the direction of spin.

NASA Image and Video Library

2003-11-03

VANDENBERG AFB, CALIF. - A worker in the NASA spacecraft processing facility on North Vandenberg Air Force Base adjust the supports on a solar array panel to be lifted and installed on the Gravity Probe B spacecraft. Installing each array is a 3-day process and includes a functional deployment test. The Gravity Probe B mission is a relativity experiment developed by NASA’s Marshall Space Flight Center, Stanford University and Lockheed Martin. The spacecraft will test two extraordinary predictions of Albert Einstein’s general theory of relativity that he advanced in 1916: the geodetic effect (how space and time are warped by the presence of the Earth) and frame dragging (how Earth’s rotation drags space and time around with it). Gravity Probe B consists of four sophisticated gyroscopes that will provide an almost perfect space-time reference system. The mission will look in a precision manner for tiny changes in the direction of spin.

Neural control and precision of flight muscle activation in Drosophila.

PubMed

Lehmann, Fritz-Olaf; Bartussek, Jan

2017-01-01

Precision of motor commands is highly relevant in a large context of various locomotor behaviors, including stabilization of body posture, heading control and directed escape responses. While posture stability and heading control in walking and swimming animals benefit from high friction via ground reaction forces and elevated viscosity of water, respectively, flying animals have to cope with comparatively little aerodynamic friction on body and wings. Although low frictional damping in flight is the key to the extraordinary aerial performance and agility of flying birds, bats and insects, it challenges these animals with extraordinary demands on sensory integration and motor precision. Our review focuses on the dynamic precision with which Drosophila activates its flight muscular system during maneuvering flight, considering relevant studies on neural and muscular mechanisms of thoracic propulsion. In particular, we tackle the precision with which flies adjust power output of asynchronous power muscles and synchronous flight control muscles by monitoring muscle calcium and spike timing within the stroke cycle. A substantial proportion of the review is engaged in the significance of visual and proprioceptive feedback loops for wing motion control including sensory integration at the cellular level. We highlight that sensory feedback is the basis for precise heading control and body stability in flies.

Estimating maneuvers for precise relative orbit determination using GPS

NASA Astrophysics Data System (ADS)

Allende-Alba, Gerardo; Montenbruck, Oliver; Ardaens, Jean-Sébastien; Wermuth, Martin; Hugentobler, Urs

2017-01-01

Precise relative orbit determination is an essential element for the generation of science products from distributed instrumentation of formation flying satellites in low Earth orbit. According to the mission profile, the required formation is typically maintained and/or controlled by executing maneuvers. In order to generate consistent and precise orbit products, a strategy for maneuver handling is mandatory in order to avoid discontinuities or precision degradation before, after and during maneuver execution. Precise orbit determination offers the possibility of maneuver estimation in an adjustment of single-satellite trajectories using GPS measurements. However, a consistent formulation of a precise relative orbit determination scheme requires the implementation of a maneuver estimation strategy which can be used, in addition, to improve the precision of maneuver estimates by drawing upon the use of differential GPS measurements. The present study introduces a method for precise relative orbit determination based on a reduced-dynamic batch processing of differential GPS pseudorange and carrier phase measurements, which includes maneuver estimation as part of the relative orbit adjustment. The proposed method has been validated using flight data from space missions with different rates of maneuvering activity, including the GRACE, TanDEM-X and PRISMA missions. The results show the feasibility of obtaining precise relative orbits without degradation in the vicinity of maneuvers as well as improved maneuver estimates that can be used for better maneuver planning in flight dynamics operations.

The promise of circulating tumor cells for precision cancer therapy

PubMed Central

Hwang, William L; Hwang, Katie L; Miyamoto, David T

2016-01-01

The rapidly growing array of therapeutic options in cancer requires informative biomarkers to guide the rational selection and precision application of appropriate therapies. Circulating biomarkers such as circulating tumor cells have immense potential as noninvasive, serial ‘liquid biopsies’ that may be more representative of the complete spectrum of a patient’s individual malignancy than spatially and temporally restricted tumor biopsies. In this review, we discuss the current state-of-the-art in the isolation and molecular characterization of circulating tumor cells as well as their utility in a wide range of clinical applications such as prognostics, treatment monitoring and identification of novel therapeutic targets and resistance mechanisms to enable real-time adjustments in the clinical management of cancer. PMID:27924634

Global adjustment for creating extended panoramic images in video-dermoscopy

NASA Astrophysics Data System (ADS)

Faraz, Khuram; Blondel, Walter; Daul, Christian

2017-07-01

This contribution presents a fast global adjustment scheme exploiting SURF descriptor locations for constructing large skin mosaics. Precision in pairwise image registration is well-preserved while significantly reducing the global mosaicing error.

Hardware accuracy counters for application precision and quality feedback

DOE Office of Scientific and Technical Information (OSTI.GOV)

de Paula Rosa Piga, Leonardo; Majumdar, Abhinandan; Paul, Indrani

Methods, devices, and systems for capturing an accuracy of an instruction executing on a processor. An instruction may be executed on the processor, and the accuracy of the instruction may be captured using a hardware counter circuit. The accuracy of the instruction may be captured by analyzing bits of at least one value of the instruction to determine a minimum or maximum precision datatype for representing the field, and determining whether to adjust a value of the hardware counter circuit accordingly. The representation may be output to a debugger or logfile for use by a developer, or may be outputmore » to a runtime or virtual machine to automatically adjust instruction precision or gating of portions of the processor datapath.« less

X, Y, Z positioner

DOEpatents

Goers, G.F.

1987-11-10

A three-axis control for precisely and conveniently adjusting items such as mirrors and lenses is disclosed. The adjuster apparatus includes a vertical stack of three rotatable adjusters. Rotation of the first effects vertical translation, whereas the second and third are eccentric assemblies which interact to effect movement along two angled axes perpendicular to the vertical axis. 13 figs.

X, Y, Z positioner

DOEpatents

Goers, George F.

1987-01-01

A three-axis control for precisely and conveniently adjusting items such as irrors and lenses is disclosed. The adjuster apparatus includes a vertical stack of three rotatable adjusters. Rotation of the first effects vertical translation, whereas the second and third are eccentric assemblies which interact to effect movement along two angled axes perpendicular to the vertical axis.

Effect of follow-up period on minimal-significant dose in the atomic-bomb survivor studies.

PubMed

Cologne, John; Preston, Dale L; Grant, Eric J; Cullings, Harry M; Ozasa, Kotaro

2018-03-01

It was recently suggested that earlier reports on solid-cancer mortality and incidence in the Life Span Study of atomic-bomb survivors contain still-useful information about low-dose risk that should not be ignored, because longer follow-up may lead to attenuated estimates of low-dose risk due to longer time since exposure. Here it is demonstrated, through the use of all follow-up data and risk models stratified on period of follow-up (as opposed to sub-setting the data by follow-up period), that the appearance of risk attenuation over time may be the result of less-precise risk estimation-in particular, imprecise estimation of effect-modification parameters-in the earlier periods. Longer follow-up, in addition to allowing more-precise estimation of risk due to larger numbers of radiation-related cases, provides more-precise adjustment for background mortality or incidence and more-accurate assessment of risk modification by age at exposure and attained age. It is concluded that the latest follow-up data are most appropriate for inferring low-dose risk. Furthermore, if researchers are interested in effects of time since exposure, the most-recent follow-up data should be considered rather than the results of earlier reports.

The Unified Levelling Network of Sarawak and its Adjustment

NASA Astrophysics Data System (ADS)

Som, Z. A. M.; Yazid, A. M.; Ming, T. K.; Yazid, N. M.

2016-09-01

The height reference network of Sarawak has seen major improvement in over the past two decades. The most significant improvement was the establishment of extended precise leveling network of which is now able to connect all three major datum points at Pulau Lakei, Original and Bintulu. Datum by following the major accessible routes across Sarawak. This means the leveling network in Sarawak has now been inter-connected and unified. By having such a unified network leads to the possibility of having a common single least squares adjustment been performed for the first time. The least squares adjustment of this unified levelling network was attempted in order to compute the height of all Bench Marks established in the entire levelling network. The adjustment was done by using MoreFix levelling adjustment package developed at FGHT UTM. The computational procedure adopted is linear parametric adjustment by minimum constraint. Since Sarawak has three separate datums therefore three separate adjustments were implemented by utilizing datum at Pulau Lakei, Original Miri and Bintulu Datum respectively. Results of the MoreFix unified adjustment agreed very well with adjustment repeated using Starnet. Further the results were compared with solution given by Jupem and they are in good agreement as well. The difference in height analysed were within 10mm for the case of minimum constraint at Pulau Lakei datum and with much better agreement in the case of Original Miri Datum.

Real-Time Precise Point Positioning (RTPPP) with raw observations and its application in real-time regional ionospheric VTEC modeling

NASA Astrophysics Data System (ADS)

Liu, Teng; Zhang, Baocheng; Yuan, Yunbin; Li, Min

2018-01-01

Precise Point Positioning (PPP) is an absolute positioning technology mainly used in post data processing. With the continuously increasing demand for real-time high-precision applications in positioning, timing, retrieval of atmospheric parameters, etc., Real-Time PPP (RTPPP) and its applications have drawn more and more research attention in recent years. This study focuses on the models, algorithms and ionospheric applications of RTPPP on the basis of raw observations, in which high-precision slant ionospheric delays are estimated among others in real time. For this purpose, a robust processing strategy for multi-station RTPPP with raw observations has been proposed and realized, in which real-time data streams and State-Space-Representative (SSR) satellite orbit and clock corrections are used. With the RTPPP-derived slant ionospheric delays from a regional network, a real-time regional ionospheric Vertical Total Electron Content (VTEC) modeling method is proposed based on Adjusted Spherical Harmonic Functions and a Moving-Window Filter. SSR satellite orbit and clock corrections from different IGS analysis centers are evaluated. Ten globally distributed real-time stations are used to evaluate the positioning performances of the proposed RTPPP algorithms in both static and kinematic modes. RMS values of positioning errors in static/kinematic mode are 5.2/15.5, 4.7/17.4 and 12.8/46.6 mm, for north, east and up components, respectively. Real-time slant ionospheric delays from RTPPP are compared with those from the traditional Carrier-to-Code Leveling (CCL) method, in terms of function model, formal precision and between-receiver differences of short baseline. Results show that slant ionospheric delays from RTPPP are more precise and have a much better convergence performance than those from the CCL method in real-time processing. 30 real-time stations from the Asia-Pacific Reference Frame network are used to model the ionospheric VTECs over Australia in real time, with slant ionospheric delays from both RTPPP and CCL methods for comparison. RMS of the VTEC differences between RTPPP/CCL method and CODE final products is 0.91/1.09 TECU, and RMS of the VTEC differences between RTPPP and CCL methods is 0.67 TECU. Slant Total Electron Contents retrieved from different VTEC models are also validated with epoch-differenced Geometry-Free combinations of dual-frequency phase observations, and mean RMS values are 2.14, 2.33 and 2.07 TECU for RTPPP method, CCL method and CODE final products, respectively. This shows the superiority of RTPPP-derived slant ionospheric delays in real-time ionospheric VTEC modeling.

Improved particle swarm optimization algorithm for android medical care IOT using modified parameters.

PubMed

Sung, Wen-Tsai; Chiang, Yen-Chun

2012-12-01

This study examines wireless sensor network with real-time remote identification using the Android study of things (HCIOT) platform in community healthcare. An improved particle swarm optimization (PSO) method is proposed to efficiently enhance physiological multi-sensors data fusion measurement precision in the Internet of Things (IOT) system. Improved PSO (IPSO) includes: inertia weight factor design, shrinkage factor adjustment to allow improved PSO algorithm data fusion performance. The Android platform is employed to build multi-physiological signal processing and timely medical care of things analysis. Wireless sensor network signal transmission and Internet links allow community or family members to have timely medical care network services.

Numerical simulation and experimentation of adjusting the curvatures of micro-cantilevers using the water-confined laser-generated plasma

NASA Astrophysics Data System (ADS)

Gu, Chunxing; Shen, Zongbao; Liu, Huixia; Li, Pin; Lu, Mengmeng; Zhao, Yinxin; Wang, Xiao

2013-04-01

This paper describes a precise and non-contact adjustment technique using the water-confined laser-generated plasma to adjust the curvature of micro-components (micro-mechanical cantilevers). A series of laser shock micro-adjustment experiments were conducted on 0.4 mm-thick Al samples using pulsed Nd:YAG lasers operating at 1064 nm wavelengths to verify the technical feasibility. Systematic study was carried out in the term of effects of various factors on the adjusting results, including laser energies, laser focus positions, laser shock times and confined regime configuration. The research results have shown that the different bending angles and bending directions can be obtained by changing the laser processing parameters. And, for the adjustment process, the absence of confined regime configuration could also generate suitable bending deformation. But, in the case of larger energy, the final surfaces would have the sign of ablation, hence resulting in poor surface quality. An analysis procedure including dynamic analysis performed by ANSYS/LS-DYNA and static analysis performed by ANSYS is presented in detail to attain the simulation of laser shock micro-adjustment to predict the final bending deformation. The predicted bending profiles is well correlated with the available experimental data, showing the finite element analysis can predict the final curvatures of the micro-cantilevers properly.

Working memory recall precision is a more sensitive index than span.

PubMed

Zokaei, Nahid; Burnett Heyes, Stephanie; Gorgoraptis, Nikos; Budhdeo, Sanjay; Husain, Masud

2015-09-01

Delayed adjustment tasks have recently been developed to examine working memory (WM) precision, that is, the resolution with which items maintained in memory are recalled. However, despite their emerging use in experimental studies of healthy people, evaluation of patient populations is sparse. We first investigated the validity of adjustment tasks, comparing precision with classical span measures of memory across the lifespan in 114 people. Second, we asked whether precision measures can potentially provide a more sensitive measure of WM than traditional span measures. Specifically, we tested this hypothesis examining WM in a group with early, untreated Parkinson's disease (PD) and its modulation by subsequent treatment on dopaminergic medication. Span measures correlated with precision across the lifespan: in children, young, and elderly participants. However, they failed to detect changes in WM in PD patients, either pre- or post-treatment initiation. By contrast, recall precision was sensitive enough to pick up such changes. PD patients pre-medication were significantly impaired compared to controls, but improved significantly after 3 months of being established on dopaminergic medication. These findings suggest that precision methods might provide a sensitive means to investigate WM and its modulation by interventions in clinical populations. © 2014 The Authors Journal of Neuropsychology published by John Wiley & Sons Ltd on behalf of British Psychological Society.

IV busulfan dose individualization in children undergoing hematopoietic stem cell transplant: limited sampling strategies.

PubMed

Dupuis, L Lee; Sibbald, Cathryn; Schechter, Tal; Ansari, Marc; Gassas, Adam; Théorêt, Yves; Kassir, Nastya; Champagne, Martin A; Doyle, John

2008-05-01

We currently calculate area under the busulfan concentration time curve (AUC) using 7 plasma busulfan concentrations (AUC7) drawn after the first of 16 i.v. busulfan doses given as a 2-hour infusion every 6 hours. The aim of this study was to develop and validate limited sampling strategies (LSSs) using 3 or fewer busulfan concentration values with which to reliably calculate AUC in children undergoing hematopoietic stem cell transplant (HSCT). Children in the development group (44) received i.v. busulfan at Sick Kids; the validation group consisted of 35 children who received care at CHU Ste-Justine. Busulfan doses given and subsequent plasma busulfan concentrations were recorded. LSSs using 1 to 3 concentration-time points were developed using multiple linear regression. LSS were considered to be acceptable when adjusted r(2) > 0.9, mean bias <15% and precision <15%. Extent of agreement between the AUC7 values and the LSS AUC was assessed by the intraclass correlation coefficient (ICC) and Bland-Altman (BA) analysis. Agreement was considered to be excellent when the lower limit of the 95% confidence limit of the ICC exceeded 0.9 and when the limits of agreement in the BA analysis were +/-15% for both AUC and dose. Administration of the theoretic adjusted busulfan doses based on each LSS was simulated and cases where the resulting AUC was >1500 or <900 microM x min were noted. LSSs using 1, 2, or 3 plasma busulfan concentrations were developed that showed excellent agreement with AUC7 and adjusted busulfan doses. In the validation sample, only the 2- and 3-point LSSs demonstrated acceptable precision and lack of bias. LSSs using 2 or 3 plasma busulfan concentrations can be used to reliably estimate busulfan AUC after IV administration in children undergoing HSCT.

Approximation of properties of hyperelastic materials with use of energy-based models and biaxial tension data

NASA Astrophysics Data System (ADS)

Jamróz, Weronika

2016-06-01

The paper shows the way enrgy-based models aproximate mechanical properties of hiperelastic materials. Main goal of research was to create a method of finding a set of material constants that are included in a strain energy function that constitutes a heart of an energy-based model. The most optimal set of material constants determines the best adjustment of a theoretical stress-strain relation to the experimental one. This kind of adjustment enables better prediction of behaviour of a chosen material. In order to obtain more precised solution the approximation was made with use of data obtained in a modern experiment widely describen in [1]. To save computation time main algorithm is based on genetic algorithms.

Total flavonoids content in the raw material and aqueous extractives from Bauhinia monandra Kurz (Caesalpiniaceae).

PubMed

Fernandes, Ana Josane Dantas; Ferreira, Magda Rhayanny Assunção; Randau, Karina Perrelli; de Souza, Tatiane Pereira; Soares, Luiz Alberto Lira

2012-01-01

The aim of this work was to evaluate the spectrophotometric methodology for determining the total flavonoid content (TFC) in herbal drug and derived products from Bauhinia monandra Kurz. Several analytical parameters from this method grounded on the complex formed between flavonoids and AlCl₃ were evaluated such as herbal amount (0.25 to 1.25 g); solvent composition (ethanol 40 to 80%, v/v); as well as the reaction time and AlCl₃ concentration (2 to 9%, w/v). The method was adjusted to aqueous extractives and its performance studied through precision, linearity and preliminary robustness. The results showed an important dependence of the method response from reaction time, AlCl₃ concentration, sample amount, and solvent mixture. After choosing the optimized condition, the method was applied for the matrixes (herbal material and extractives), showing precision lower than 5% (for both parameters repeatability and intermediate precision), coefficient of determination higher than 0.99, and no important influence could be observed for slight variations from wavelength or AlCl₃ concentration. Thus, it could be concluded that the evaluated analytical procedure was suitable to quantify the total flavonoid content in raw material and aqueous extractives from leaves of B. monandra.

Optimization of the Brillouin operator on the KNL architecture

NASA Astrophysics Data System (ADS)

Dürr, Stephan

2018-03-01

Experiences with optimizing the matrix-times-vector application of the Brillouin operator on the Intel KNL processor are reported. Without adjustments to the memory layout, performance figures of 360 Gflop/s in single and 270 Gflop/s in double precision are observed. This is with Nc = 3 colors, Nv = 12 right-hand-sides, Nthr = 256 threads, on lattices of size 323 × 64, using exclusively OMP pragmas. Interestingly, the same routine performs quite well on Intel Core i7 architectures, too. Some observations on the much harderWilson fermion matrix-times-vector optimization problem are added.

Faster quantum walk search on a weighted graph

NASA Astrophysics Data System (ADS)

Wong, Thomas G.

2015-09-01

A randomly walking quantum particle evolving by Schrödinger's equation searches for a unique marked vertex on the "simplex of complete graphs" in time Θ (N3 /4) . We give a weighted version of this graph that preserves vertex transitivity, and we show that the time to search on it can be reduced to nearly Θ (√{N }) . To prove this, we introduce two extensions to degenerate perturbation theory: an adjustment that distinguishes the weights of the edges and a method to determine how precisely the jumping rate of the quantum walk must be chosen.

Examining Exposure Assessment in Shift Work Research: A Study on Depression Among Nurses.

PubMed

Hall, Amy L; Franche, Renée-Louise; Koehoorn, Mieke

2018-02-13

Coarse exposure assessment and assignment is a common issue facing epidemiological studies of shift work. Such measures ignore a number of exposure characteristics that may impact on health, increasing the likelihood of biased effect estimates and masked exposure-response relationships. To demonstrate the impacts of exposure assessment precision in shift work research, this study investigated relationships between work schedule and depression in a large survey of Canadian nurses. The Canadian 2005 National Survey of the Work and Health of Nurses provided the analytic sample (n = 11450). Relationships between work schedule and depression were assessed using logistic regression models with high, moderate, and low-precision exposure groupings. The high-precision grouping described shift timing and rotation frequency, the moderate-precision grouping described shift timing, and the low-precision grouping described the presence/absence of shift work. Final model estimates were adjusted for the potential confounding effects of demographic and work variables, and bootstrap weights were used to generate sampling variances that accounted for the survey sample design. The high-precision exposure grouping model showed the strongest relationships between work schedule and depression, with increased odds ratios [ORs] for rapidly rotating (OR = 1.51, 95% confidence interval [CI] = 0.91-2.51) and undefined rotating (OR = 1.67, 95% CI = 0.92-3.02) shift workers, and a decreased OR for depression in slow rotating (OR = 0.79, 95% CI = 0.57-1.08) shift workers. For the low- and moderate-precision exposure grouping models, weak relationships were observed for all work schedule categories (OR range 0.95 to 0.99). Findings from this study support the need to consider and collect the data required for precise and conceptually driven exposure assessment and assignment in future studies of shift work and health. Further research into the effects of shift rotation frequency on depression is also recommended. © The Author(s) 2018. Published by Oxford University Press on behalf of the British Occupational Hygiene Society.

Precision mass measurements of some isotopes of tungsten and mercury for an adjustment to the mass table in the region A = 184 to A = 204

NASA Astrophysics Data System (ADS)

Barillari, Domenico K.

This thesis concerns the precise re-measurement of mass values in the region of the mercury isotopes, such that important discrepancies in the high-mass end of the mass table could be resolved. Scope and contents. Four mass spectroscopic doublets involving a comparison between 201Hg, 199Hg and 183W (and using a chlorocarbon reference) are reported from measurements made with the upgraded Manitoba 11 deflection instrument. The measurements address the problem of a mass table mis-adjustment in the region of the valley of β-stability between the tungsten group and the noble metals. The results, forming a well-closed loop of mass differences, support the earlier results of Kozier [Ko(1977)] regarding the (stable) mercury isotope masses and confirm an approximate 20 μu discrepancy in the mass adjustment of Audi et al [Au(1993)]. A local least- square re-adjustment conducted using these and existing mass table data suggests that the error originates with mass differences pertaining to one or more other nuclide pairs, perhaps 193Ir-192Ir. The work on upgrading the precision voltage supply and potentiometry system of the Manitoba II instrument is also reported, as is a new assessment on the data processing method. (Abstract shortened by UMI.)

Optogenetic feedback control of neural activity

PubMed Central

Newman, Jonathan P; Fong, Ming-fai; Millard, Daniel C; Whitmire, Clarissa J; Stanley, Garrett B; Potter, Steve M

2015-01-01

Optogenetic techniques enable precise excitation and inhibition of firing in specified neuronal populations and artifact-free recording of firing activity. Several studies have suggested that optical stimulation provides the precision and dynamic range requisite for closed-loop neuronal control, but no approach yet permits feedback control of neuronal firing. Here we present the ‘optoclamp’, a feedback control technology that provides continuous, real-time adjustments of bidirectional optical stimulation in order to lock spiking activity at specified targets over timescales ranging from seconds to days. We demonstrate how this system can be used to decouple neuronal firing levels from ongoing changes in network excitability due to multi-hour periods of glutamatergic or GABAergic neurotransmission blockade in vitro as well as impinging vibrissal sensory drive in vivo. This technology enables continuous, precise optical control of firing in neuronal populations in order to disentangle causally related variables of circuit activation in a physiologically and ethologically relevant manner. DOI: http://dx.doi.org/10.7554/eLife.07192.001 PMID:26140329

A real-time detector system for precise timing of audiovisual stimuli.

PubMed

Henelius, Andreas; Jagadeesan, Sharman; Huotilainen, Minna

2012-01-01

The successful recording of neurophysiologic signals, such as event-related potentials (ERPs) or event-related magnetic fields (ERFs), relies on precise information of stimulus presentation times. We have developed an accurate and flexible audiovisual sensor solution operating in real-time for on-line use in both auditory and visual ERP and ERF paradigms. The sensor functions independently of the used audio or video stimulus presentation tools or signal acquisition system. The sensor solution consists of two independent sensors; one for sound and one for light. The microcontroller-based audio sensor incorporates a novel approach to the detection of natural sounds such as multipart audio stimuli, using an adjustable dead time. This aids in producing exact markers for complex auditory stimuli and reduces the number of false detections. The analog photosensor circuit detects changes in light intensity on the screen and produces a marker for changes exceeding a threshold. The microcontroller software for the audio sensor is free and open source, allowing other researchers to customise the sensor for use in specific auditory ERP/ERF paradigms. The hardware schematics and software for the audiovisual sensor are freely available from the webpage of the authors' lab.

Marine chronometry in the Neuchatel mountains (Switzerland)

NASA Astrophysics Data System (ADS)

Fallet, Estelle

The history and evolution of the Swiss marine chronometer industry are summarized. From the 18th century onwards, Neuchatel watchmakers strove to develop precision horology. First J. F. Houriet and later S. Mairet, L. Richard, W. Dubois and H. Grandjean introduced the marine chronometer in the Neuchatel mountains. Precision having become a necessity for the industry, they helped achive this by means of a complex system for the distribution and maintenance of exact time, which allowed optimal adjustment. These men of vision called for the building of a cantonal observatory and strove to have their art practiced in modern watchmaking schools. Under the guidance first of Ulysse and then of Paul David Nardin, the manufacture of marine chronometers began in Le Locle in 1876. In La Chaux-de-Fonds at the beginning of the 20th century, Paul Ditisheim built a number of improved marine, ship and pocket chronometers. Together with scientists and watchmakers, the chronometer makers perfected the regulating parts of the timekeepers and solved the problems of adjustment caused by the various external influences. The manufacturers, the watchmakers at their branches, the timers and the Neuchatel business all contributed to strengthening the position of the products of their region in the world market.

Biosonar navigation above water I: estimating flight height.

PubMed

Hoffmann, Susanne; Genzel, Daria; Prosch, Selina; Baier, Leonie; Weser, Sabrina; Wiegrebe, Lutz; Firzlaff, Uwe

2015-02-15

Locomotion and foraging on the wing require precise navigation in more than just the horizontal plane. Navigation in three dimensions and, specifically, precise adjustment of flight height are essential for flying animals. Echolocating bats drink from water surfaces in flight, which requires an exceptionally precise vertical navigation. Here, we exploit this behavior in the bat, Phyllostomus discolor, to understand the biophysical and neural mechanisms that allow for sonar-guided navigation in the vertical plane. In a set of behavioral experiments, we show that for echolocating bats, adjustment of flight height depends on the tragus in their outer ears. Specifically, the tragus imposes elevation-specific spectral interference patterns on the echoes of the bats' sonar emissions. Head-related transfer functions of our bats show that these interference patterns are most conspicuous in the frequency range ∼55 kHz. This conspicuousness is faithfully preserved in the frequency tuning and spatial receptive fields of cortical single and multiunits recorded from anesthetized animals. In addition, we recorded vertical spatiotemporal response maps that describe neural tuning in elevation over time. One class of units that were very sharply tuned to frequencies ∼55 kHz showed unusual spatiotemporal response characteristics with a preference for paired echoes where especially the first echo originates from very low elevations. These behavioral and neural data provide the first insight into biosonar-based processing and perception of acoustic elevation cues that are essential for bats to navigate in three-dimensional space. Copyright © 2015 the American Physiological Society.

The iMars web-GIS - spatio-temporal data queries and single image web map services

NASA Astrophysics Data System (ADS)

Walter, S. H. G.; Steikert, R.; Schreiner, B.; Sidiropoulos, P.; Tao, Y.; Muller, J.-P.; Putry, A. R. D.; van Gasselt, S.

2017-09-01

We introduce a new approach for a system dedicated to planetary surface change detection by simultaneous visualisation of single-image time series in a multi-temporal context. In the context of the EU FP-7 iMars project we process and ingest vast amounts of automatically co-registered (ACRO) images. The base of the co-registration are the high precision HRSC multi-orbit quadrangle image mosaics, which are based on bundle-block-adjusted multi-orbit HRSC DTMs.

Understanding heart rate alarm adjustment in the intensive care units through an analytical approach.

PubMed

Fidler, Richard L; Pelter, Michele M; Drew, Barbara J; Palacios, Jorge Arroyo; Bai, Yong; Stannard, Daphne; Aldrich, J Matt; Hu, Xiao

2017-01-01

Heart rate (HR) alarms are prevalent in ICU, and these parameters are configurable. Not much is known about nursing behavior associated with tailoring HR alarm parameters to individual patients to reduce clinical alarm fatigue. To understand the relationship between heart rate (HR) alarms and adjustments to reduce unnecessary heart rate alarms. Retrospective, quantitative analysis of an adjudicated database using analytical approaches to understand behaviors surrounding parameter HR alarm adjustments. Patients were sampled from five adult ICUs (77 beds) over one month at a quaternary care university medical center. A total of 337 of 461 ICU patients had HR alarms with 53.7% male, mean age 60.3 years, and 39% non-Caucasian. Default HR alarm parameters were 50 and 130 beats per minute (bpm). The occurrence of each alarm, vital signs, and physiologic waveforms was stored in a relational database (SQL server). There were 23,624 HR alarms for analysis, with 65.4% exceeding the upper heart rate limit. Only 51% of patients with HR alarms had parameters adjusted, with a median upper limit change of +5 bpm and -1 bpm lower limit. The median time to first HR parameter adjustment was 17.9 hours, without reduction in alarms occurrence (p = 0.57). HR alarms are prevalent in ICU, and half of HR alarm settings remain at default. There is a long delay between HR alarms and parameters changes, with insufficient changes to decrease HR alarms. Increasing frequency of HR alarms shortens the time to first adjustment. Best practice guidelines for HR alarm limits are needed to reduce alarm fatigue and improve monitoring precision.

Accounting for individual differences and timing of events: estimating the effect of treatment on criminal convictions in heroin users.

PubMed

Røislien, Jo; Clausen, Thomas; Gran, Jon Michael; Bukten, Anne

2014-05-17

The reduction of crime is an important outcome of opioid maintenance treatment (OMT). Criminal intensity and treatment regimes vary among OMT patients, but this is rarely adjusted for in statistical analyses, which tend to focus on cohort incidence rates and rate ratios. The purpose of this work was to estimate the relationship between treatment and criminal convictions among OMT patients, adjusting for individual covariate information and timing of events, fitting time-to-event regression models of increasing complexity. National criminal records were cross linked with treatment data on 3221 patients starting OMT in Norway 1997-2003. In addition to calculating cohort incidence rates, criminal convictions was modelled as a recurrent event dependent variable, and treatment a time-dependent covariate, in Cox proportional hazards, Aalen's additive hazards, and semi-parametric additive hazards regression models. Both fixed and dynamic covariates were included. During OMT, the number of days with criminal convictions for the cohort as a whole was 61% lower than when not in treatment. OMT was associated with reduced number of days with criminal convictions in all time-to-event regression models, but the hazard ratio (95% CI) was strongly attenuated when adjusting for covariates; from 0.40 (0.35, 0.45) in a univariate model to 0.79 (0.72, 0.87) in a fully adjusted model. The hazard was lower for females and decreasing with older age, while increasing with high numbers of criminal convictions prior to application to OMT (all p < 0.001). The strongest predictors were level of criminal activity prior to entering into OMT, and having a recent criminal conviction (both p < 0.001). The effect of several predictors was significantly time-varying with their effects diminishing over time. Analyzing complex observational data regarding to fixed factors only overlooks important temporal information, and naïve cohort level incidence rates might result in biased estimates of the effect of interventions. Applying time-to-event regression models, properly adjusting for individual covariate information and timing of various events, allows for more precise and reliable effect estimates, as well as painting a more nuanced picture that can aid health care professionals and policy makers.

Computer-aided system of evaluation for population-based all-in-one service screening (CASE-PASS): from study design to outcome analysis with bias adjustment.

PubMed

Chen, Li-Sheng; Yen, Amy Ming-Fang; Duffy, Stephen W; Tabar, Laszlo; Lin, Wen-Chou; Chen, Hsiu-Hsi

2010-10-01

Population-based routine service screening has gained popularity following an era of randomized controlled trials. The evaluation of these service screening programs is subject to study design, data availability, and the precise data analysis for adjusting bias. We developed a computer-aided system that allows the evaluation of population-based service screening to unify these aspects and facilitate and guide the program assessor to efficiently perform an evaluation. This system underpins two experimental designs: the posttest-only non-equivalent design and the one-group pretest-posttest design and demonstrates the type of data required at both the population and individual levels. Three major analyses were developed that included a cumulative mortality analysis, survival analysis with lead-time adjustment, and self-selection bias adjustment. We used SAS AF software to develop a graphic interface system with a pull-down menu style. We demonstrate the application of this system with data obtained from a Swedish population-based service screen and a population-based randomized controlled trial for the screening of breast, colorectal, and prostate cancer, and one service screening program for cervical cancer with Pap smears. The system provided automated descriptive results based on the various sources of available data and cumulative mortality curves corresponding to the study designs. The comparison of cumulative survival between clinically and screen-detected cases without a lead-time adjustment are also demonstrated. The intention-to-treat and noncompliance analysis with self-selection bias adjustments are also shown to assess the effectiveness of the population-based service screening program. Model validation was composed of a comparison between our adjusted self-selection bias estimates and the empirical results on effectiveness reported in the literature. We demonstrate a computer-aided system allowing the evaluation of population-based service screening programs with an adjustment for self-selection and lead-time bias. This is achieved by providing a tutorial guide from the study design to the data analysis, with bias adjustment. Copyright © 2010 Elsevier Inc. All rights reserved.

Research on the phase adjustment method for dispersion interferometer on HL-2A tokamak

NASA Astrophysics Data System (ADS)

Tongyu, WU; Wei, ZHANG; Haoxi, WANG; Yan, ZHOU; Zejie, YIN

2018-06-01

A synchronous demodulation system is proposed and deployed for CO2 dispersion interferometer on HL-2A, which aims at high plasma density measurements and real-time feedback control. In order to make sure that the demodulator and the interferometer signal are synchronous in phase, a phase adjustment (PA) method has been developed for the demodulation system. The method takes advantages of the field programmable gate array parallel and pipeline process capabilities to carry out high performance and low latency PA. Some experimental results presented show that the PA method is crucial to the synchronous demodulation system and reliable to follow the fast change of the electron density. The system can measure the line-integrated density with a high precision of 2.0 × 1018 m‑2.

Application of Sensor Technology for the Efficient Positioningand Assembling of Ship Blocks

NASA Astrophysics Data System (ADS)

Lee, Sangdon; SeongbaeEun; Jung, Jai Jin; Song, Hacheol

2010-09-01

This paper proposes the application of sensor technology to assemble ship blocks efficiently. A sensor-based monitoring system is designed and implemented to improve shipbuilding productivity by reducing the labor cost for the adjustment of adequate positioning between ship blocks during pre-erection or erection stage. For the real-time remote monitoring of relative distances between two ship blocks, sensor nodes are applied to measure the distances between corresponding target points on the blocks. Highly precise positioning data can be transferred to a monitoring server via wireless network, and analyzed to support the decision making which needs to determine the next construction process; further adjustment or seam welding between the ship blocks. The developed system is expected to put to practical use, and increase the productivity during ship blocks assembly.

[The role of neurologists in deep brain stimulation for Parkinson disease: a neurosurgical perspective].

PubMed

Umemura, Atsushi

2012-01-01

Deep brain stimulation (DBS) has been accepted as an effective treatment for medically refractory Parkinson disease (PD). Appropriate patient selection, safe and precise surgery, and proper postoperative adjustment of stimulation and medication, are essential for the success of DBS. Patient selection is the most important role for the neurologist in DBS treatment. Neurologists treating PD should understand the correct indications and contraindications for DBS, and introduce it in a timely manner to patients who can be expected to benefit substantially from it. For long term treatment of PD, ideally the neurologist in charge of the patient should adjust both the stimulation parameters and medication. Neurologists engaged in this treatment should also have a comprehensive understanding of the probable complications and how to avoid them.

Spatial variability effects on precision and power of forage yield estimation

USDA-ARS?s Scientific Manuscript database

Spatial analyses of yield trials are important, as they adjust cultivar means for spatial variation and improve the statistical precision of yield estimation. While the relative efficiency of spatial analysis has been frequently reported in several yield trials, its application on long-term forage y...

Development of a laser-guided embedded-computer-controlled air-assisted precision sprayer

USDA-ARS?s Scientific Manuscript database

An embedded computer-controlled, laser-guided, air-assisted, variable-rate precision sprayer was developed to automatically adjust spray outputs on both sides of the sprayer to match presence, size, shape, and foliage density of tree crops. The sprayer was the integration of an embedded computer, a ...

A step in time: Changes in standard-frequency and time-signal broadcasts, 1 January 1972

NASA Technical Reports Server (NTRS)

Chi, A. R.; Fosque, H. S.

1973-01-01

An improved coordinated universal time (UTC) system has been adopted by the International Radio Consultative Committee. It was implemented internationally by the standard-frequency and time-broadcast stations on 1 Jan. 1972. The new UTC system eliminates the frequency offset of 300 parts in 10 to the 10th power between the old UTC and atomic time, thus making the broadcast time interval (the UTC second) constant and defined by the resonant frequency of cesium atoms. The new time scale is kept in synchronism with the rotation of the Earth within plus or minus 0.7 s by step-time adjustments of exactly 1 s, when needed. A time code has been added to the disseminated time signals to permit universal time to be obtained from the broadcasts to the nearest 0.1 s for users requiring such precision. The texts of the International Radio Consultative Committee recommendation and report to implement the new UTC system are given. The coding formats used by various standard time broadcast services to transmit the difference between the universal time (UT1) and the UTC are also given. For users' convenience, worldwide primary VLF and HF transmissions stations, frequencies, and schedules of time emissions are also included. Actual time-step adjustments made by various stations on 1 Jan. 1972, are provided for future reference.

Continuous monitoring of haemoglobin concentration after in-vivo adjustment in patients undergoing surgery with blood loss.

PubMed

Frasca, D; Mounios, H; Giraud, B; Boisson, M; Debaene, B; Mimoz, O

2015-07-01

Non-invasive monitoring of haemoglobin concentration provides real-time measurement of haemoglobin concentration (SpHb) using multi-wavelength pulse co-oximetry. We hypothesised that in-vivo adjustment using the mean of three haemoglobinometer (HemoCue®) measurements from an arterial blood sample at the first SpHb measurement (HCueART) would increase the accuracy of the monitor. The study included 41 adults for a total of 173 measurements of haemoglobin concentration. In-vivo adjusted SpHb was automatically calculated by the following formula: in-vivo adjusted SpHb = unadjusted SpHb - (SpHb - HCueART). The accuracy of in-vivo adjusted SpHb was compared with SpHb retrospectively adjusted using the same formula, except for haemoglobin level which was assessed at the central laboratory and then compared with all other available invasive methods of haemoglobin measurement (co-oximetry, HbSAT; arterial HemoCue, HCueART; capillary HemoCue, HCueCAP). Compared with laboratory measurement of haemoglobin concentration, bias (precision) for unadjusted SpHb, in-vivo adjusted SpHb, retrospectively adjusted SpHb, HbSAT, HCueART and HCueCAP were -0.4 (1.4), -0.3 (1.1), -0.3 (1.1), -0.6 (0.7), 0.0 (0.4) and -0.5 (1.2) g.dl(-1) , respectively. In-vivo adjustment of SpHb values using the mean of three arterial HemoCue measurements improved the accuracy of the device similar to those observed after a retrospective adjustment using central laboratory haemoglobin level. © 2015 The Association of Anaesthetists of Great Britain and Ireland.

Impact of orbit, clock and EOP errors in GNSS Precise Point Positioning

NASA Astrophysics Data System (ADS)

Hackman, C.

2012-12-01

Precise point positioning (PPP; [1]) has gained ever-increasing usage in GNSS carrier-phase positioning, navigation and timing (PNT) since its inception in the late 1990s. In this technique, high-precision satellite clocks, satellite ephemerides and earth-orientation parameters (EOPs) are applied as fixed input by the user in order to estimate receiver/location-specific quantities such as antenna coordinates, troposphere delay and receiver-clock corrections. This is in contrast to "network" solutions, in which (typically) less-precise satellite clocks, satellite ephemerides and EOPs are used as input, and in which these parameters are estimated simultaneously with the receiver/location-specific parameters. The primary reason for increased PPP application is that it offers most of the benefits of a network solution with a smaller computing cost. In addition, the software required to do PPP positioning can be simpler than that required for network solutions. Finally, PPP permits high-precision positioning of single or sparsely spaced receivers that may have few or no GNSS satellites in common view. A drawback of PPP is that the accuracy of the results depend directly on the accuracy of the supplied orbits, clocks and EOPs, since these parameters are not adjusted during the processing. In this study, we will examine the impact of orbit, EOP and satellite clock estimates on PPP solutions. Our primary focus will be the impact of these errors on station coordinates; however the study may be extended to error propagation into receiver-clock corrections and/or troposphere estimates if time permits. Study motivation: the United States Naval Observatory (USNO) began testing PPP processing using its own predicted orbits, clocks and EOPs in Summer 2012 [2]. The results of such processing could be useful for real- or near-real-time applications should they meet accuracy/precision requirements. Understanding how errors in satellite clocks, satellite orbits and EOPs propagate into PPP positioning and timing results allows researchers to focus their improvement efforts in areas most in need of attention. The initial study will be conducted using the simulation capabilities of Bernese GPS Software and extended to using real data if time permits. [1] J.F. Zumberge, M.B. Heflin, D.C. Jefferson, M.M. Watkins and F.H. Webb, Precise point positioning for the efficient and robust analysis of GPS data from large networks, J. Geophys. Res., 102(B3), 5005-5017, doi:10.1029/96JB03860, 1997. [2] C. Hackman, S.M. Byram, V.J. Slabinski and J.C. Tracey, Near-real-time and other high-precision GNSS-based orbit/clock/earth-orientation/troposphere parameters available from USNO, Proc. 2012 ION Joint Navigation Conference, 15 pp., in press, 2012.

Precise determination of lattice phase shifts and mixing angles

DOE PAGES

Lu, Bing -Nan; Lähde, Timo A.; Lee, Dean; ...

2016-07-09

Here, we introduce a general and accurate method for determining lattice phase shifts and mixing angles, which is applicable to arbitrary, non-cubic lattices. Our method combines angular momentum projection, spherical wall boundaries and an adjustable auxiliary potential. This allows us to construct radial lattice wave functions and to determine phase shifts at arbitrary energies. For coupled partial waves, we use a complex-valued auxiliary potential that breaks time-reversal invariance. We benchmark our method using a system of two spin-1/2 particles interacting through a finite-range potential with a strong tensor component. We are able to extract phase shifts and mixing angles formore » all angular momenta and energies, with precision greater than that of extant methods. We discuss a wide range of applications from nuclear lattice simulations to optical lattice experiments.« less

CODATA recommended values of the fundamental constants

NASA Astrophysics Data System (ADS)

Mohr, Peter J.; Taylor, Barry N.

2000-11-01

A review is given of the latest Committee on Data for Science and Technology (CODATA) adjustment of the values of the fundamental constants. The new set of constants, referred to as the 1998 values, replaces the values recommended for international use by CODATA in 1986. The values of the constants, and particularly the Rydberg constant, are of relevance to the calculation of precise atomic spectra. The standard uncertainty (estimated standard deviation) of the new recommended value of the Rydberg constant, which is based on precision frequency metrology and a detailed analysis of the theory, is approximately 1/160 times the uncertainty of the 1986 value. The new set of recommended values as well as a searchable bibliographic database that gives citations to the relevant literature is available on the World Wide Web at physics.nist.gov/constants and physics.nist.gov/constantsbib, respectively. .

Assessment of physical activity of the human body considering the thermodynamic system.

PubMed

Hochstein, Stefan; Rauschenberger, Philipp; Weigand, Bernhard; Siebert, Tobias; Schmitt, Syn; Schlicht, Wolfgang; Převorovská, Světlana; Maršík, František

2016-01-01

Correctly dosed physical activity is the basis of a vital and healthy life, but the measurement of physical activity is certainly rather empirical resulting in limited individual and custom activity recommendations. Certainly, very accurate three-dimensional models of the cardiovascular system exist, however, requiring the numeric solution of the Navier-Stokes equations of the flow in blood vessels. These models are suitable for the research of cardiac diseases, but computationally very expensive. Direct measurements are expensive and often not applicable outside laboratories. This paper offers a new approach to assess physical activity using thermodynamical systems and its leading quantity of entropy production which is a compromise between computation time and precise prediction of pressure, volume, and flow variables in blood vessels. Based on a simplified (one-dimensional) model of the cardiovascular system of the human body, we develop and evaluate a setup calculating entropy production of the heart to determine the intensity of human physical activity in a more precise way than previous parameters, e.g. frequently used energy considerations. The knowledge resulting from the precise real-time physical activity provides the basis for an intelligent human-technology interaction allowing to steadily adjust the degree of physical activity according to the actual individual performance level and thus to improve training and activity recommendations.

Total Flavonoids Content in the Raw Material and Aqueous Extractives from Bauhinia monandra Kurz (Caesalpiniaceae)

PubMed Central

Fernandes, Ana Josane Dantas; Ferreira, Magda Rhayanny Assunção; Randau, Karina Perrelli; de Souza, Tatiane Pereira; Soares, Luiz Alberto Lira

2012-01-01

The aim of this work was to evaluate the spectrophotometric methodology for determining the total flavonoid content (TFC) in herbal drug and derived products from Bauhinia monandra Kurz. Several analytical parameters from this method grounded on the complex formed between flavonoids and AlCl3 were evaluated such as herbal amount (0.25 to 1.25 g); solvent composition (ethanol 40 to 80%, v/v); as well as the reaction time and AlCl3 concentration (2 to 9%, w/v). The method was adjusted to aqueous extractives and its performance studied through precision, linearity and preliminary robustness. The results showed an important dependence of the method response from reaction time, AlCl3 concentration, sample amount, and solvent mixture. After choosing the optimized condition, the method was applied for the matrixes (herbal material and extractives), showing precision lower than 5% (for both parameters repeatability and intermediate precision), coefficient of determination higher than 0.99, and no important influence could be observed for slight variations from wavelength or AlCl3 concentration. Thus, it could be concluded that the evaluated analytical procedure was suitable to quantify the total flavonoid content in raw material and aqueous extractives from leaves of B. monandra. PMID:22701375

The system of high accuracy UV spectral radiation system

NASA Astrophysics Data System (ADS)

Lin, Guan-yu; Yu, Lei; Xu, Dian; Cao, Dian-sheng; Yu, Yu-Xiang

2016-10-01

UV spectral radiation detecting and visible observation telescope is designed by the coaxial optical. In order to decrease due to the incident light polarization effect, and improve the detection precision, polarizer need to be used in the light path. Four pieces of quartz of high Precision UV radiation depolarizer retarder stack together is placed in front of Seya namioka dispersion unit. The coherent detection principle of modulation of light signal and the reference signal multiplied processing, increase the phase sensitive detector can be adjustment function, ensure the UV spectral radiation detection stability. A lock-in amplifier is used in the electrical system to advance the accuracy of measurement. To ensure the precision measurement detected, the phase-sensitive detector function can be adjustable. the output value is not more than 10mV before each measurement, so it can be ensured that the stability of the measured radiation spectrum is less than 1 percent.

The importance of precision radar tracking data for the determination of density and winds from the high-altitude inflatable sphere

NASA Technical Reports Server (NTRS)

Schmidlin, F. J.; Michel, W. R.

1985-01-01

Analysis of inflatable sphere measurements obtained during the Energy Budget and MAP/WINE campaigns led to questions concerning the precision of the MPS-36 radar used for tracking the spheres; the compatibility of the sphere program with the MPS-36 radar tracking data; and the oversmoothing of derived parameters at high altitudes. Simulations, with winds having sinusoidal vertical wavelengths, were done with the sphere program (HIROBIN) to determine the resolving capability of various filters. It is concluded that given a precision radar and a perfectly performing sphere, the HIROBIN filters can be adjusted to provide small-scale perturbation information to 70 km (i.e., sinusoidal wavelengths of 2 km). It is recommended that the HIROBIN program be modified to enable it to use a variable length filter, that adjusts to fall velocity and accelerations to provide wind data with small perturbations.

Improving regression-model-based streamwater constituent load estimates derived from serially correlated data

USGS Publications Warehouse

Aulenbach, Brent T.

2013-01-01

A regression-model based approach is a commonly used, efficient method for estimating streamwater constituent load when there is a relationship between streamwater constituent concentration and continuous variables such as streamwater discharge, season and time. A subsetting experiment using a 30-year dataset of daily suspended sediment observations from the Mississippi River at Thebes, Illinois, was performed to determine optimal sampling frequency, model calibration period length, and regression model methodology, as well as to determine the effect of serial correlation of model residuals on load estimate precision. Two regression-based methods were used to estimate streamwater loads, the Adjusted Maximum Likelihood Estimator (AMLE), and the composite method, a hybrid load estimation approach. While both methods accurately and precisely estimated loads at the model’s calibration period time scale, precisions were progressively worse at shorter reporting periods, from annually to monthly. Serial correlation in model residuals resulted in observed AMLE precision to be significantly worse than the model calculated standard errors of prediction. The composite method effectively improved upon AMLE loads for shorter reporting periods, but required a sampling interval of at least 15-days or shorter, when the serial correlations in the observed load residuals were greater than 0.15. AMLE precision was better at shorter sampling intervals and when using the shortest model calibration periods, such that the regression models better fit the temporal changes in the concentration–discharge relationship. The models with the largest errors typically had poor high flow sampling coverage resulting in unrepresentative models. Increasing sampling frequency and/or targeted high flow sampling are more efficient approaches to ensure sufficient sampling and to avoid poorly performing models, than increasing calibration period length.

Understanding heart rate alarm adjustment in the intensive care units through an analytical approach

PubMed Central

Pelter, Michele M.; Drew, Barbara J.; Palacios, Jorge Arroyo; Bai, Yong; Stannard, Daphne; Aldrich, J. Matt; Hu, Xiao

2017-01-01

Background Heart rate (HR) alarms are prevalent in ICU, and these parameters are configurable. Not much is known about nursing behavior associated with tailoring HR alarm parameters to individual patients to reduce clinical alarm fatigue. Objectives To understand the relationship between heart rate (HR) alarms and adjustments to reduce unnecessary heart rate alarms. Methods Retrospective, quantitative analysis of an adjudicated database using analytical approaches to understand behaviors surrounding parameter HR alarm adjustments. Patients were sampled from five adult ICUs (77 beds) over one month at a quaternary care university medical center. A total of 337 of 461 ICU patients had HR alarms with 53.7% male, mean age 60.3 years, and 39% non-Caucasian. Default HR alarm parameters were 50 and 130 beats per minute (bpm). The occurrence of each alarm, vital signs, and physiologic waveforms was stored in a relational database (SQL server). Results There were 23,624 HR alarms for analysis, with 65.4% exceeding the upper heart rate limit. Only 51% of patients with HR alarms had parameters adjusted, with a median upper limit change of +5 bpm and -1 bpm lower limit. The median time to first HR parameter adjustment was 17.9 hours, without reduction in alarms occurrence (p = 0.57). Conclusions HR alarms are prevalent in ICU, and half of HR alarm settings remain at default. There is a long delay between HR alarms and parameters changes, with insufficient changes to decrease HR alarms. Increasing frequency of HR alarms shortens the time to first adjustment. Best practice guidelines for HR alarm limits are needed to reduce alarm fatigue and improve monitoring precision. PMID:29176776

An Innovate Robotic Endoscope Guidance System for Transnasal Sinus and Skull Base Surgery: Proof of Concept.

PubMed

Friedrich, D T; Sommer, F; Scheithauer, M O; Greve, J; Hoffmann, T K; Schuler, P J

2017-12-01

Objective  Advanced transnasal sinus and skull base surgery remains a challenging discipline for head and neck surgeons. Restricted access and space for instrumentation can impede advanced interventions. Thus, we present the combination of an innovative robotic endoscope guidance system and a specific endoscope with adjustable viewing angle to facilitate transnasal surgery in a human cadaver model. Materials and Methods  The applicability of the robotic endoscope guidance system with custom foot pedal controller was tested for advanced transnasal surgery on a fresh frozen human cadaver head. Visualization was enabled using a commercially available endoscope with adjustable viewing angle (15-90 degrees). Results  Visualization and instrumentation of all paranasal sinuses, including the anterior and middle skull base, were feasible with the presented setup. Controlling the robotic endoscope guidance system was effectively precise, and the adjustable endoscope lens extended the view in the surgical field without the common change of fixed viewing angle endoscopes. Conclusion  The combination of a robotic endoscope guidance system and an advanced endoscope with adjustable viewing angle enables bimanual surgery in transnasal interventions of the paranasal sinuses and the anterior skull base in a human cadaver model. The adjustable lens allows for the abandonment of fixed-angle endoscopes, saving time and resources, without reducing the quality of imaging.

Scanning digital lithography providing high speed large area patterning with diffraction limited sub-micron resolution

NASA Astrophysics Data System (ADS)

Wen, Sy-Bor; Bhaskar, Arun; Zhang, Hongjie

2018-07-01

A scanning digital lithography system using computer controlled digital spatial light modulator, spatial filter, infinity correct optical microscope and high precision translation stage is proposed and examined. Through utilizing the spatial filter to limit orders of diffraction modes for light delivered from the spatial light modulator, we are able to achieve diffraction limited deep submicron spatial resolution with the scanning digital lithography system by using standard one inch level optical components with reasonable prices. Raster scanning of this scanning digital lithography system using a high speed high precision x-y translation stage and piezo mount to real time adjust the focal position of objective lens allows us to achieve large area sub-micron resolved patterning with high speed (compared with e-beam lithography). It is determined in this study that to achieve high quality stitching of lithography patterns with raster scanning, a high-resolution rotation stage will be required to ensure the x and y directions of the projected pattern are in the same x and y translation directions of the nanometer precision x-y translation stage.

Adaptive x-ray optics development at AOA-Xinetics

NASA Astrophysics Data System (ADS)

Lillie, Charles F.; Cavaco, Jeff L.; Brooks, Audrey D.; Ezzo, Kevin; Pearson, David D.; Wellman, John A.

2013-05-01

Grazing-incidence optics for X-ray applications require extremely smooth surfaces with precise mirror figures to provide well focused beams and small image spot sizes for astronomical telescopes and laboratory test facilities. The required precision has traditionally been achieved by time-consuming grinding and polishing of thick substrates with frequent pauses for precise metrology to check the mirror figure. More recently, substrates with high quality surface finish and figures have become available at reasonable cost, and techniques have been developed to mechanically adjust the figure of these traditionally polished substrates for ground-based applications. The beam-bending techniques currently in use are mechanically complex, however, with little control over mid-spatial frequency errors. AOA-Xinetics has been developing been developing techniques for shaping grazing incidence optics with surface-normal and surface-parallel electrostrictive Lead magnesium niobate (PMN) actuators bonded to mirror substrates for several years. These actuators are highly reliable; exhibit little to no hysteresis, aging or creep; and can be closely spaced to correct low and mid-spatial frequency errors in a compact package. In this paper we discuss recent development of adaptive x-ray optics at AOA-Xinetics.

Adaptive x-ray optics development at AOA-Xinetics

NASA Astrophysics Data System (ADS)

Lillie, Charles F.; Pearson, David D.; Cavaco, Jeffrey L.; Plinta, Audrey D.; Wellman, John A.

2012-10-01

Grazing-incidence optics for X-ray applications require extremely smooth surfaces with precise mirror figures to provide well focused beams and small image spot sizes for astronomical telescopes and laboratory test facilities. The required precision has traditionally been achieved by time-consuming grinding and polishing of thick substrates with frequent pauses for precise metrology to check the mirror figure. More recently, substrates with high quality surface finish and figures have become available at reasonable cost, and techniques have been developed to mechanically adjust the figure of these traditionally polished substrates for ground-based applications. The beam-bending techniques currently in use are mechanically complex, however, with little control over mid-spatial frequency errors. AOA-Xinetics has been developing been developing techniques for shaping grazing incidence optics with surface-normal and surface-parallel electrostrictive Lead magnesium niobate (PMN) actuators bonded to mirror substrates for several years. These actuators are highly reliable; exhibit little to no hysteresis, aging or creep; and can be closely spaced to correct low and mid-spatial frequency errors in a compact package. In this paper we discuss recent development of adaptive x-ray optics at AOAXinetics.

Rigorous accuracy assessment for 3D reconstruction using time-series Dual Fluoroscopy (DF) image pairs

NASA Astrophysics Data System (ADS)

Al-Durgham, Kaleel; Lichti, Derek D.; Kuntze, Gregor; Ronsky, Janet

2017-06-01

High-speed biplanar videoradiography, or clinically referred to as dual fluoroscopy (DF), imaging systems are being used increasingly for skeletal kinematics analysis. Typically, a DF system comprises two X-ray sources, two image intensifiers and two high-speed video cameras. The combination of these elements provides time-series image pairs of articulating bones of a joint, which permits the measurement of bony rotation and translation in 3D at high temporal resolution (e.g., 120-250 Hz). Assessment of the accuracy of 3D measurements derived from DF imaging has been the subject of recent research efforts by several groups, however with methodological limitations. This paper presents a novel and simple accuracy assessment procedure based on using precise photogrammetric tools. We address the fundamental photogrammetry principles for the accuracy evaluation of an imaging system. Bundle adjustment with selfcalibration is used for the estimation of the system parameters. The bundle adjustment calibration uses an appropriate sensor model and applies free-network constraints and relative orientation stability constraints for a precise estimation of the system parameters. A photogrammetric intersection of time-series image pairs is used for the 3D reconstruction of a rotating planar object. A point-based registration method is used to combine the 3D coordinates from the intersection and independently surveyed coordinates. The final DF accuracy measure is reported as the distance between 3D coordinates from image intersection and the independently surveyed coordinates. The accuracy assessment procedure is designed to evaluate the accuracy over the full DF image format and a wide range of object rotation. Experiment of reconstruction of a rotating planar object reported an average positional error of 0.44 +/- 0.2 mm in the derived 3D coordinates (minimum 0.05 and maximum 1.2 mm).

Accuracy of Cycling Power Meters against a Mathematical Model of Treadmill Cycling.

PubMed

Maier, Thomas; Schmid, Lucas; Müller, Beat; Steiner, Thomas; Wehrlin, Jon Peter

2017-06-01

The aim of this study was to compare the accuracy among a high number of current mobile cycling power meters used by elite and recreational cyclists against a first principle-based mathematical model of treadmill cycling. 54 power meters from 9 manufacturers used by 32 cyclists were calibrated. While the cyclist coasted downhill on a motorised treadmill, a back-pulling system was adjusted to counter the downhill force. The system was then loaded 3 times with 4 different masses while the cyclist pedalled to keep his position. The mean deviation (trueness) to the model and coefficient of variation (precision) were analysed. The mean deviations of the power meters were -0.9±3.2% (mean±SD) with 6 power meters deviating by more than±5%. The coefficients of variation of the power meters were 1.2±0.9% (mean±SD), with Stages varying more than SRM (p<0.001) and PowerTap (p<0.001). In conclusion, current power meters used by elite and recreational cyclists vary considerably in their trueness; precision is generally high but differs between manufacturers. Calibrating and adjusting the trueness of every power meter against a first principle-based reference is advised for accurate measurements. © Georg Thieme Verlag KG Stuttgart · New York.

Innovation, productivity, and pricing: Capturing value from precision medicine technology in Canada.

PubMed

Emery, J C Herbert; Zwicker, Jennifer D

2017-07-01

For new technology and innovation such as precision medicine to become part of the solution for the fiscal sustainability of Canadian Medicare, decision-makers need to change how services are priced rather than trying to restrain emerging technologies like precision medicine for short-term cost savings. If provincial public payers shift their thinking to be public purchasers, value considerations would direct reform of the reimbursement system to have prices that adjust with technologically driven productivity gains. This strategic shift in thinking is necessary if Canadians are to benefit from the promised benefits of innovations like precision medicine.

Automatic Phase Calibration for RF Cavities using Beam-Loading Signals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Edelen, J. P.; Chase, B. E.

Precise calibration of the cavity phase signals is necessary for the operation of any particle accelerator. For many systems this requires human in the loop adjustments based on measurements of the beam parameters downstream. Some recent work has developed a scheme for the calibration of the cavity phase using beam measurements and beam-loading however this scheme is still a multi-step process that requires heavy automation or human in the loop. In this paper we analyze a new scheme that uses only RF signals reacting to beam-loading to calculate the phase of the beam relative to the cavity. This technique couldmore » be used in slow control loops to provide real-time adjustment of the cavity phase calibration without human intervention thereby increasing the stability and reliability of the accelerator.« less

Evaluation of AUC(0-4) predictive methods for cyclosporine in kidney transplant patients.

PubMed

Aoyama, Takahiko; Matsumoto, Yoshiaki; Shimizu, Makiko; Fukuoka, Masamichi; Kimura, Toshimi; Kokubun, Hideya; Yoshida, Kazunari; Yago, Kazuo

2005-05-01

Cyclosporine (CyA) is the most commonly used immunosuppressive agent in patients who undergo kidney transplantation. Dosage adjustment of CyA is usually based on trough levels. Recently, trough levels have been replacing the area under the concentration-time curve during the first 4 h after CyA administration (AUC(0-4)). The aim of this study was to compare the predictive values obtained using three different methods of AUC(0-4) monitoring. AUC(0-4) was calculated from 0 to 4 h in early and stable renal transplant patients using the trapezoidal rule. The predicted AUC(0-4) was calculated using three different methods: the multiple regression equation reported by Uchida et al.; Bayesian estimation for modified population pharmacokinetic parameters reported by Yoshida et al.; and modified population pharmacokinetic parameters reported by Cremers et al. The predicted AUC(0-4) was assessed on the basis of predictive bias, precision, and correlation coefficient. The predicted AUC(0-4) values obtained using three methods through measurement of three blood samples showed small differences in predictive bias, precision, and correlation coefficient. In the prediction of AUC(0-4) measurement of one blood sample from stable renal transplant patients, the performance of the regression equation reported by Uchida depended on sampling time. On the other hand, the performance of Bayesian estimation with modified pharmacokinetic parameters reported by Yoshida through measurement of one blood sample, which is not dependent on sampling time, showed a small difference in the correlation coefficient. The prediction of AUC(0-4) using a regression equation required accurate sampling time. In this study, the prediction of AUC(0-4) using Bayesian estimation did not require accurate sampling time in the AUC(0-4) monitoring of CyA. Thus Bayesian estimation is assumed to be clinically useful in the dosage adjustment of CyA.

Should English healthcare providers be penalised for failing to collect patient-reported outcome measures? A retrospective analysis

PubMed Central

Street, Andrew; Gomes, Manuel; Bojke, Chris

2015-01-01

Summary Objective The best practice tariff for hip and knee replacement in the English National Health Service (NHS) rewards providers based on improvements in patient-reported outcome measures (PROMs) collected before and after surgery. Providers only receive a bonus if at least 50% of their patients complete the preoperative questionnaire. We determined how many providers failed to meet this threshold prior to the policy introduction and assessed longitudinal stability of participation rates. Design Retrospective observational study using data from Hospital Episode Statistics and the national PROM programme from April 2009 to March 2012. We calculated participation rates based on either (a) all PROM records or (b) only those that could be linked to inpatient records; constructed confidence intervals around rates to account for sampling variation; applied precision weighting to allow for volume; and applied risk adjustment. Setting NHS hospitals and private providers in England. Participants NHS patients undergoing elective unilateral hip and knee replacement surgery. Main outcome measures Number of providers with participation rates statistically significantly below 50%. Results Crude rates identified many providers that failed to achieve the 50% threshold but there were substantially fewer after adjusting for uncertainty and precision. While important, risk adjustment required restricting the analysis to linked data. Year-on-year correlation between provider participation rates was moderate. Conclusions Participation rates have improved over time and only a small number of providers now fall below the threshold, but administering preoperative questionnaires remains problematic in some providers. We recommend that participation rates are based on linked data and take into account sampling variation. PMID:25827906

Should English healthcare providers be penalised for failing to collect patient-reported outcome measures? A retrospective analysis.

PubMed

Gutacker, Nils; Street, Andrew; Gomes, Manuel; Bojke, Chris

2015-08-01

The best practice tariff for hip and knee replacement in the English National Health Service (NHS) rewards providers based on improvements in patient-reported outcome measures (PROMs) collected before and after surgery. Providers only receive a bonus if at least 50% of their patients complete the preoperative questionnaire. We determined how many providers failed to meet this threshold prior to the policy introduction and assessed longitudinal stability of participation rates. Retrospective observational study using data from Hospital Episode Statistics and the national PROM programme from April 2009 to March 2012. We calculated participation rates based on either (a) all PROM records or (b) only those that could be linked to inpatient records; constructed confidence intervals around rates to account for sampling variation; applied precision weighting to allow for volume; and applied risk adjustment. NHS hospitals and private providers in England. NHS patients undergoing elective unilateral hip and knee replacement surgery. Number of providers with participation rates statistically significantly below 50%. Crude rates identified many providers that failed to achieve the 50% threshold but there were substantially fewer after adjusting for uncertainty and precision. While important, risk adjustment required restricting the analysis to linked data. Year-on-year correlation between provider participation rates was moderate. Participation rates have improved over time and only a small number of providers now fall below the threshold, but administering preoperative questionnaires remains problematic in some providers. We recommend that participation rates are based on linked data and take into account sampling variation. © The Royal Society of Medicine.

A FORTRAN version implementation of block adjustment of CCD frames and its preliminary application

NASA Astrophysics Data System (ADS)

Yu, Y.; Tang, Z.-H.; Li, J.-L.; Zhao, M.

2005-09-01

A FORTRAN version implementation of the block adjustment (BA) of overlapping CCD frames is developed and its flowchart is shown. The program is preliminarily applied to obtain the optical positions of four extragalactic radio sources. The results show that because of the increase in the number and sky coverage of reference stars the precision of optical positions with BA is improved compared with the single CCD frame adjustment.

Precision manometer gauge

DOEpatents

McPherson, Malcolm J.; Bellman, Robert A.

1984-01-01

A precision manometer gauge which locates a zero height and a measured height of liquid using an open tube in communication with a reservoir adapted to receive the pressure to be measured. The open tube has a reference section carried on a positioning plate which is moved vertically with machine tool precision. Double scales are provided to read the height of the positioning plate accurately, the reference section being inclined for accurate meniscus adjustment, and means being provided to accurately locate a zero or reference position.

Precision manometer gauge

DOEpatents

McPherson, M.J.; Bellman, R.A.

1982-09-27

A precision manometer gauge which locates a zero height and a measured height of liquid using an open tube in communication with a reservoir adapted to receive the pressure to be measured. The open tube has a reference section carried on a positioning plate which is moved vertically with machine tool precision. Double scales are provided to read the height of the positioning plate accurately, the reference section being inclined for accurate meniscus adjustment, and means being provided to accurately locate a zero or reference position.

Specificity of Postural Sway to the Demands of a Precision Task at Sea

ERIC Educational Resources Information Center

Chen, Fu-Chen; Stoffregen, Thomas A.

2012-01-01

Mariners actively adjust their body orientation in response to ship motion. On a ship at sea, we evaluated relations between standing postural activity and the performance of a precision aiming task. Standing participants (experienced mariners) maintained the beam from a handheld laser on a target. Targets were large or small, thereby varying the…

Precision lens assembly with alignment turning system

NASA Astrophysics Data System (ADS)

Ho, Cheng-Fang; Huang, Chien-Yao; Lin, Yi-Hao; Kuo, Hui-Jean; Kuo, Ching-Hsiang; Hsu, Wei-Yao; Chen, Fong-Zhi

2017-10-01

The poker chip assembly with high precision lens barrels is widely applied to ultra-high performance optical system. ITRC applies the poker chip assembly technology to the high numerical aperture objective lenses and lithography projection lenses because of its high efficiency assembly process. In order to achieve high precision lens cell for poker chip assembly, an alignment turning system (ATS) is developed. The ATS includes measurement, alignment and turning modules. The measurement module is equipped with a non-contact displacement sensor (NCDS) and an autocollimator (ACM). The NCDS and ACM are used to measure centration errors of the top and the bottom surface of a lens respectively; then the amount of adjustment of displacement and tilt with respect to the rotational axis of the turning machine for the alignment module can be determined. After measurement, alignment and turning processes on the ATS, the centration error of a lens cell with 200 mm in diameter can be controlled within 10 arcsec. Furthermore, a poker chip assembly lens cell with three sub-cells is demonstrated, each sub-cells are measured and accomplished with alignment and turning processes. The lens assembly test for five times by each three technicians; the average transmission centration error of assembly lens is 12.45 arcsec. The results show that ATS can achieve high assembly efficiency for precision optical systems.

Analog-to-digital conversion techniques for precision photometry

NASA Technical Reports Server (NTRS)

Opal, Chet B.

1988-01-01

Three types of analog-to-digital converters are described: parallel, successive-approximation, and integrating. The functioning of comparators and sample-and-hold amplifiers is explained. Differential and integral linearity are defined, and good and bad examples are illustrated. The applicability and relative advantages of the three types of converters for precision astronomical photometric measurements are discussed. For most measurements, integral linearity is more important than differential linearity. Successive-approximation converters should be used with multielement solid state detectors because of their high speed, but dual slope integrating converters may be superior for use with single element solid state detectors where speed of digitization is not a factor. In all cases, the input signal should be tailored so that they occupy the upper part of the converter's dynamic range; this can be achieved by providing adjustable gain, or better by varying the integration time of the observation if possible.

Monitoring of stability of ASG-EUPOS network coordinates

NASA Astrophysics Data System (ADS)

Figurski, M.; Szafranek, K.; Wrona, M.

2009-04-01

ASG-EUPOS (Active Geodetic Network - European Position Determination System) is the national system of precise satellite positioning in Poland, which increases a density of regional and global GNSS networks and is widely used by public administration, national institutions, entrepreneurs and citizens (especially surveyors). In near future ASG-EUPOS is to take role of main national network. Control of proper activity of stations and realization of ETRS'89 is a necessity. User of the system needs to be sure that observations quality and coordinates accuracy are high enough. Coordinates of IGS (International GNSS Service) and EPN (European Permanent Network) stations are precisely determined and any changes are monitored all the time. Observations are verified before they are archived in regional and global databases. The same applies to ASG-EUPOS. This paper concerns standardization of GNSS observations from different stations (uniform adjustment), examination of solutions correctness according to IGS and EPN standards and stability of solutions and sites activity

An innovative browser-based data exploration tool with simultaneous scrolling in time and wavelength domains

NASA Astrophysics Data System (ADS)

Slater, Gregory L.; Schiff, David; De Pontieu, Bart; Tarbell, Theodore D.; Freeland, Samuel L.

2017-08-01

We present Cruiser, a new web tool for the precision interactive blending of image series across time and wavelength domains. Scrolling in two dimensions enables discovery and investigation of similarities and differences in structure and evolution across multiple wavelengths. Cruiser works in the latest versions of standards compliant browsers on both desktop and IOS platforms. Co-aligned data cubes have been generated for AIA, IRIS, and Hinode SOT FG, and image data from additional instruments, both space-based and ground-based, can be data sources. The tool has several movie playing and image adjustment controls which will be described in the poster and demonstrated on a MacOS notebook and iPad.

Can statistic adjustment of OR minimize the potential confounding bias for meta-analysis of case-control study? A secondary data analysis.

PubMed

Liu, Tianyi; Nie, Xiaolu; Wu, Zehao; Zhang, Ying; Feng, Guoshuang; Cai, Siyu; Lv, Yaqi; Peng, Xiaoxia

2017-12-29

Different confounder adjustment strategies were used to estimate odds ratios (ORs) in case-control study, i.e. how many confounders original studies adjusted and what the variables are. This secondary data analysis is aimed to detect whether there are potential biases caused by difference of confounding factor adjustment strategies in case-control study, and whether such bias would impact the summary effect size of meta-analysis. We included all meta-analyses that focused on the association between breast cancer and passive smoking among non-smoking women, as well as each original case-control studies included in these meta-analyses. The relative deviations (RDs) of each original study were calculated to detect how magnitude the adjustment would impact the estimation of ORs, compared with crude ORs. At the same time, a scatter diagram was sketched to describe the distribution of adjusted ORs with different number of adjusted confounders. Substantial inconsistency existed in meta-analysis of case-control studies, which would influence the precision of the summary effect size. First, mixed unadjusted and adjusted ORs were used to combine individual OR in majority of meta-analysis. Second, original studies with different adjustment strategies of confounders were combined, i.e. the number of adjusted confounders and different factors being adjusted in each original study. Third, adjustment did not make the effect size of original studies trend to constringency, which suggested that model fitting might have failed to correct the systematic error caused by confounding. The heterogeneity of confounder adjustment strategies in case-control studies may lead to further bias for summary effect size in meta-analyses, especially for weak or medium associations so that the direction of causal inference would be even reversed. Therefore, further methodological researches are needed, referring to the assessment of confounder adjustment strategies, as well as how to take this kind of bias into consideration when drawing conclusion based on summary estimation of meta-analyses.

Fast-Time Evaluations of Airborne Merging and Spacing in Terminal Arrival Operations

NASA Technical Reports Server (NTRS)

Krishnamurthy, Karthik; Barmore, Bryan; Bussink, Frank; Weitz, Lesley; Dahlene, Laura

2005-01-01

NASA researchers are developing new airborne technologies and procedures to increase runway throughput at capacity-constrained airports by improving the precision of inter-arrival spacing at the runway threshold. In this new operational concept, pilots of equipped aircraft are cleared to adjust aircraft speed to achieve a designated spacing interval at the runway threshold, relative to a designated lead aircraft. A new airborne toolset, prototypes of which are being developed at the NASA Langley Research Center, assists pilots in achieving this objective. The current prototype allows precision spacing operations to commence even when the aircraft and its lead are not yet in-trail, but are on merging arrival routes to the runway. A series of fast-time evaluations of the new toolset were conducted at the Langley Research Center during the summer of 2004. The study assessed toolset performance in a mixed fleet of aircraft on three merging arrival streams under a range of operating conditions. The results of the study indicate that the prototype possesses a high degree of robustness to moderate variations in operating conditions.

Empirical likelihood inference in randomized clinical trials.

PubMed

Zhang, Biao

2017-01-01

In individually randomized controlled trials, in addition to the primary outcome, information is often available on a number of covariates prior to randomization. This information is frequently utilized to undertake adjustment for baseline characteristics in order to increase precision of the estimation of average treatment effects; such adjustment is usually performed via covariate adjustment in outcome regression models. Although the use of covariate adjustment is widely seen as desirable for making treatment effect estimates more precise and the corresponding hypothesis tests more powerful, there are considerable concerns that objective inference in randomized clinical trials can potentially be compromised. In this paper, we study an empirical likelihood approach to covariate adjustment and propose two unbiased estimating functions that automatically decouple evaluation of average treatment effects from regression modeling of covariate-outcome relationships. The resulting empirical likelihood estimator of the average treatment effect is as efficient as the existing efficient adjusted estimators 1 when separate treatment-specific working regression models are correctly specified, yet are at least as efficient as the existing efficient adjusted estimators 1 for any given treatment-specific working regression models whether or not they coincide with the true treatment-specific covariate-outcome relationships. We present a simulation study to compare the finite sample performance of various methods along with some results on analysis of a data set from an HIV clinical trial. The simulation results indicate that the proposed empirical likelihood approach is more efficient and powerful than its competitors when the working covariate-outcome relationships by treatment status are misspecified.

Accounting for individual differences and timing of events: estimating the effect of treatment on criminal convictions in heroin users

PubMed Central

2014-01-01

Background The reduction of crime is an important outcome of opioid maintenance treatment (OMT). Criminal intensity and treatment regimes vary among OMT patients, but this is rarely adjusted for in statistical analyses, which tend to focus on cohort incidence rates and rate ratios. The purpose of this work was to estimate the relationship between treatment and criminal convictions among OMT patients, adjusting for individual covariate information and timing of events, fitting time-to-event regression models of increasing complexity. Methods National criminal records were cross linked with treatment data on 3221 patients starting OMT in Norway 1997–2003. In addition to calculating cohort incidence rates, criminal convictions was modelled as a recurrent event dependent variable, and treatment a time-dependent covariate, in Cox proportional hazards, Aalen’s additive hazards, and semi-parametric additive hazards regression models. Both fixed and dynamic covariates were included. Results During OMT, the number of days with criminal convictions for the cohort as a whole was 61% lower than when not in treatment. OMT was associated with reduced number of days with criminal convictions in all time-to-event regression models, but the hazard ratio (95% CI) was strongly attenuated when adjusting for covariates; from 0.40 (0.35, 0.45) in a univariate model to 0.79 (0.72, 0.87) in a fully adjusted model. The hazard was lower for females and decreasing with older age, while increasing with high numbers of criminal convictions prior to application to OMT (all p < 0.001). The strongest predictors were level of criminal activity prior to entering into OMT, and having a recent criminal conviction (both p < 0.001). The effect of several predictors was significantly time-varying with their effects diminishing over time. Conclusions Analyzing complex observational data regarding to fixed factors only overlooks important temporal information, and naïve cohort level incidence rates might result in biased estimates of the effect of interventions. Applying time-to-event regression models, properly adjusting for individual covariate information and timing of various events, allows for more precise and reliable effect estimates, as well as painting a more nuanced picture that can aid health care professionals and policy makers. PMID:24886472

Performance of Stratified and Subgrouped Disproportionality Analyses in Spontaneous Databases.

PubMed

Seabroke, Suzie; Candore, Gianmario; Juhlin, Kristina; Quarcoo, Naashika; Wisniewski, Antoni; Arani, Ramin; Painter, Jeffery; Tregunno, Philip; Norén, G Niklas; Slattery, Jim

2016-04-01

Disproportionality analyses are used in many organisations to identify adverse drug reactions (ADRs) from spontaneous report data. Reporting patterns vary over time, with patient demographics, and between different geographical regions, and therefore subgroup analyses or adjustment by stratification may be beneficial. The objective of this study was to evaluate the performance of subgroup and stratified disproportionality analyses for a number of key covariates within spontaneous report databases of differing sizes and characteristics. Using a reference set of established ADRs, signal detection performance (sensitivity and precision) was compared for stratified, subgroup and crude (unadjusted) analyses within five spontaneous report databases (two company, one national and two international databases). Analyses were repeated for a range of covariates: age, sex, country/region of origin, calendar time period, event seriousness, vaccine/non-vaccine, reporter qualification and report source. Subgroup analyses consistently performed better than stratified analyses in all databases. Subgroup analyses also showed benefits in both sensitivity and precision over crude analyses for the larger international databases, whilst for the smaller databases a gain in precision tended to result in some loss of sensitivity. Additionally, stratified analyses did not increase sensitivity or precision beyond that associated with analytical artefacts of the analysis. The most promising subgroup covariates were age and region/country of origin, although this varied between databases. Subgroup analyses perform better than stratified analyses and should be considered over the latter in routine first-pass signal detection. Subgroup analyses are also clearly beneficial over crude analyses for larger databases, but further validation is required for smaller databases.

Kinematic precision of gear trains

NASA Technical Reports Server (NTRS)

Litvin, F. L.; Goldrich, R. N.; Coy, J. J.; Zaretsky, E. V.

1982-01-01

Kinematic precision is affected by errors which are the result of either intentional adjustments or accidental defects in manufacturing and assembly of gear trains. A method for the determination of kinematic precision of gear trains is described. The method is based on the exact kinematic relations for the contact point motions of the gear tooth surfaces under the influence of errors. An approximate method is also explained. Example applications of the general approximate methods are demonstrated for gear trains consisting of involute (spur and helical) gears, circular arc (Wildhaber-Novikov) gears, and spiral bevel gears. Gear noise measurements from a helicopter transmission are presented and discussed with relation to the kinematic precision theory.

The application of GPS precise point positioning technology in aerial triangulation

NASA Astrophysics Data System (ADS)

Yuan, Xiuxiao; Fu, Jianhong; Sun, Hongxing; Toth, Charles

In traditional GPS-supported aerotriangulation, differential GPS (DGPS) positioning technology is used to determine the 3-dimensional coordinates of the perspective centers at exposure time with an accuracy of centimeter to decimeter level. This method can significantly reduce the number of ground control points (GCPs). However, the establishment of GPS reference stations for DGPS positioning is not only labor-intensive and costly, but also increases the implementation difficulty of aerial photography. This paper proposes aerial triangulation supported with GPS precise point positioning (PPP) as a way to avoid the use of the GPS reference stations and simplify the work of aerial photography. Firstly, we present the algorithm for GPS PPP in aerial triangulation applications. Secondly, the error law of the coordinate of perspective centers determined using GPS PPP is analyzed. Thirdly, based on GPS PPP and aerial triangulation software self-developed by the authors, four sets of actual aerial images taken from surveying and mapping projects, different in both terrain and photographic scale, are given as experimental models. The four sets of actual data were taken over a flat region at a scale of 1:2500, a mountainous region at a scale of 1:3000, a high mountainous region at a scale of 1:32000 and an upland region at a scale of 1:60000 respectively. In these experiments, the GPS PPP results were compared with results obtained through DGPS positioning and traditional bundle block adjustment. In this way, the empirical positioning accuracy of GPS PPP in aerial triangulation can be estimated. Finally, the results of bundle block adjustment with airborne GPS controls from GPS PPP are analyzed in detail. The empirical results show that GPS PPP applied in aerial triangulation has a systematic error of half-meter level and a stochastic error within a few decimeters. However, if a suitable adjustment solution is adopted, the systematic error can be eliminated in GPS-supported bundle block adjustment. When four full GCPs are emplaced in the corners of the adjustment block, then the systematic error is compensated using a set of independent unknown parameters for each strip, the final result of the bundle block adjustment with airborne GPS controls from PPP is the same as that of bundle block adjustment with airborne GPS controls from DGPS. Although the accuracy of the former is a little lower than that of traditional bundle block adjustment with dense GCPs, it can still satisfy the accuracy requirement of photogrammetric point determination for topographic mapping at many scales.

A Flexile and High Precision Calibration Method for Binocular Structured Light Scanning System

PubMed Central

Yuan, Jianying; Wang, Qiong; Li, Bailin

2014-01-01

3D (three-dimensional) structured light scanning system is widely used in the field of reverse engineering, quality inspection, and so forth. Camera calibration is the key for scanning precision. Currently, 2D (two-dimensional) or 3D fine processed calibration reference object is usually applied for high calibration precision, which is difficult to operate and the cost is high. In this paper, a novel calibration method is proposed with a scale bar and some artificial coded targets placed randomly in the measuring volume. The principle of the proposed method is based on hierarchical self-calibration and bundle adjustment. We get initial intrinsic parameters from images. Initial extrinsic parameters in projective space are estimated with the method of factorization and then upgraded to Euclidean space with orthogonality of rotation matrix and rank 3 of the absolute quadric as constraint. Last, all camera parameters are refined through bundle adjustment. Real experiments show that the proposed method is robust, and has the same precision level as the result using delicate artificial reference object, but the hardware cost is very low compared with the current calibration method used in 3D structured light scanning system. PMID:25202736

Adjustable link for kinematic mounting systems

DOEpatents

Hale, Layton C.

1997-01-01

An adjustable link for kinematic mounting systems. The adjustable link is a low-cost, passive device that provides backlash-free adjustment along its single constraint direction and flexural freedom in all other directions. The adjustable link comprises two spheres, two sockets in which the spheres are adjustable retain, and a connection link threadly connected at each end to the spheres, to provide a single direction of restraint and to adjust the length or distance between the sockets. Six such adjustable links provide for six degrees of freedom for mounting an instrument on a support. The adjustable link has applications in any machine or instrument requiring precision adjustment in six degrees of freedom, isolation from deformations of the supporting platform, and/or additional structural damping. The damping is accomplished by using a hollow connection link that contains an inner rod and a viscoelastic separation layer between the two.

Adjustable link for kinematic mounting systems

DOEpatents

Hale, L.C.

1997-07-01

An adjustable link for kinematic mounting systems is disclosed. The adjustable link is a low-cost, passive device that provides backlash-free adjustment along its single constraint direction and flexural freedom in all other directions. The adjustable link comprises two spheres, two sockets in which the spheres are adjustable retain, and a connection link threadly connected at each end to the spheres, to provide a single direction of restraint and to adjust the length or distance between the sockets. Six such adjustable links provide for six degrees of freedom for mounting an instrument on a support. The adjustable link has applications in any machine or instrument requiring precision adjustment in six degrees of freedom, isolation from deformations of the supporting platform, and/or additional structural damping. The damping is accomplished by using a hollow connection link that contains an inner rod and a viscoelastic separation layer between the two. 3 figs.

Development and evaluation of a biomedical search engine using a predicate-based vector space model.

PubMed

Kwak, Myungjae; Leroy, Gondy; Martinez, Jesse D; Harwell, Jeffrey

2013-10-01

Although biomedical information available in articles and patents is increasing exponentially, we continue to rely on the same information retrieval methods and use very few keywords to search millions of documents. We are developing a fundamentally different approach for finding much more precise and complete information with a single query using predicates instead of keywords for both query and document representation. Predicates are triples that are more complex datastructures than keywords and contain more structured information. To make optimal use of them, we developed a new predicate-based vector space model and query-document similarity function with adjusted tf-idf and boost function. Using a test bed of 107,367 PubMed abstracts, we evaluated the first essential function: retrieving information. Cancer researchers provided 20 realistic queries, for which the top 15 abstracts were retrieved using a predicate-based (new) and keyword-based (baseline) approach. Each abstract was evaluated, double-blind, by cancer researchers on a 0-5 point scale to calculate precision (0 versus higher) and relevance (0-5 score). Precision was significantly higher (p<.001) for the predicate-based (80%) than for the keyword-based (71%) approach. Relevance was almost doubled with the predicate-based approach-2.1 versus 1.6 without rank order adjustment (p<.001) and 1.34 versus 0.98 with rank order adjustment (p<.001) for predicate--versus keyword-based approach respectively. Predicates can support more precise searching than keywords, laying the foundation for rich and sophisticated information search. Copyright © 2013 Elsevier Inc. All rights reserved.

Color Feature-Based Object Tracking through Particle Swarm Optimization with Improved Inertia Weight

PubMed Central

Guo, Siqiu; Zhang, Tao; Song, Yulong

2018-01-01

This paper presents a particle swarm tracking algorithm with improved inertia weight based on color features. The weighted color histogram is used as the target feature to reduce the contribution of target edge pixels in the target feature, which makes the algorithm insensitive to the target non-rigid deformation, scale variation, and rotation. Meanwhile, the influence of partial obstruction on the description of target features is reduced. The particle swarm optimization algorithm can complete the multi-peak search, which can cope well with the object occlusion tracking problem. This means that the target is located precisely where the similarity function appears multi-peak. When the particle swarm optimization algorithm is applied to the object tracking, the inertia weight adjustment mechanism has some limitations. This paper presents an improved method. The concept of particle maturity is introduced to improve the inertia weight adjustment mechanism, which could adjust the inertia weight in time according to the different states of each particle in each generation. Experimental results show that our algorithm achieves state-of-the-art performance in a wide range of scenarios. PMID:29690610

Color Feature-Based Object Tracking through Particle Swarm Optimization with Improved Inertia Weight.

PubMed

Guo, Siqiu; Zhang, Tao; Song, Yulong; Qian, Feng

2018-04-23

This paper presents a particle swarm tracking algorithm with improved inertia weight based on color features. The weighted color histogram is used as the target feature to reduce the contribution of target edge pixels in the target feature, which makes the algorithm insensitive to the target non-rigid deformation, scale variation, and rotation. Meanwhile, the influence of partial obstruction on the description of target features is reduced. The particle swarm optimization algorithm can complete the multi-peak search, which can cope well with the object occlusion tracking problem. This means that the target is located precisely where the similarity function appears multi-peak. When the particle swarm optimization algorithm is applied to the object tracking, the inertia weight adjustment mechanism has some limitations. This paper presents an improved method. The concept of particle maturity is introduced to improve the inertia weight adjustment mechanism, which could adjust the inertia weight in time according to the different states of each particle in each generation. Experimental results show that our algorithm achieves state-of-the-art performance in a wide range of scenarios.

Touchfree medical interfaces.

PubMed

Rossol, Nathaniel; Cheng, Irene; Rui Shen; Basu, Anup

2014-01-01

Real-time control of visual display systems via mid-air hand gestures offers many advantages over traditional interaction modalities. In medicine, for example, it allows a practitioner to adjust display values, e.g. contrast or zoom, on a medical visualization interface without the need to re-sterilize the interface. However, when users are holding a small tool (such as a pen, surgical needle, or computer stylus) the need to constantly put the tool down in order to make hand gesture interactions is not ideal. This work presents a novel interface that automatically adjusts for gesturing with hands and hand-held tools to precisely control medical displays. The novelty of our interface is that it uses a single set of gestures designed to be equally effective for fingers and hand-held tools without using markers. This type of interface was previously not feasible with low-resolution depth sensors such as Kinect, but is now achieved by using the recently released Leap Motion controller. Our interface is validated through a user study on a group of people given the task of adjusting parameters on a medical image.

Precision Control Module For UV Laser 3D Micromachining

NASA Astrophysics Data System (ADS)

Wu, Wen-Hong; Hung, Min-Wei; Chang, Chun-Li

2011-01-01

UV laser has been widely used in various micromachining such as micro-scribing or patterning processing. At present, most of the semiconductors, LEDs, photovoltaic solar panels and touch panels industries need the UV laser processing system. However, most of the UV laser processing applications in the industries utilize two dimensional (2D) plane processing. And there are tremendous business opportunities that can be developed, such as three dimensional (3D) structures of micro-electromechanical (MEMS) sensor or the precision depth control of indium tin oxide (ITO) thin films edge insulation in touch panels. This research aims to develop a UV laser 3D micromachining module that can create the novel applications for industries. By special designed beam expender in optical system, the focal point of UV laser can be adjusted quickly and accurately through the optical path control lens of laser beam expender optical system. Furthermore, the integrated software for galvanometric scanner and focal point adjustment mechanism is developed as well, so as to carry out the precise 3D microstructure machining.

A novel multi-scale adaptive sampling-based approach for energy saving in leak detection for WSN-based water pipelines

NASA Astrophysics Data System (ADS)

Saqib, Najam us; Faizan Mysorewala, Muhammad; Cheded, Lahouari

2017-12-01

In this paper, we propose a novel monitoring strategy for a wireless sensor networks (WSNs)-based water pipeline network. Our strategy uses a multi-pronged approach to reduce energy consumption based on the use of two types of vibration sensors and pressure sensors, all having different energy levels, and a hierarchical adaptive sampling mechanism to determine the sampling frequency. The sampling rate of the sensors is adjusted according to the bandwidth of the vibration signal being monitored by using a wavelet-based adaptive thresholding scheme that calculates the new sampling frequency for the following cycle. In this multimodal sensing scheme, the duty-cycling approach is used for all sensors to reduce the sampling instances, such that the high-energy, high-precision (HE-HP) vibration sensors have low duty cycles, and the low-energy, low-precision (LE-LP) vibration sensors have high duty cycles. The low duty-cycling (HE-HP) vibration sensor adjusts the sampling frequency of the high duty-cycling (LE-LP) vibration sensor. The simulated test bed considered here consists of a water pipeline network which uses pressure and vibration sensors, with the latter having different energy consumptions and precision levels, at various locations in the network. This is all the more useful for energy conservation for extended monitoring. It is shown that by using the novel features of our proposed scheme, a significant reduction in energy consumption is achieved and the leak is effectively detected by the sensor node that is closest to it. Finally, both the total energy consumed by monitoring as well as the time to detect the leak by a WSN node are computed, and show the superiority of our proposed hierarchical adaptive sampling algorithm over a non-adaptive sampling approach.

A neurorobotic platform for locomotor prosthetic development in rats and mice

NASA Astrophysics Data System (ADS)

von Zitzewitz, Joachim; Asboth, Leonie; Fumeaux, Nicolas; Hasse, Alexander; Baud, Laetitia; Vallery, Heike; Courtine, Grégoire

2016-04-01

Objectives. We aimed to develop a robotic interface capable of providing finely-tuned, multidirectional trunk assistance adjusted in real-time during unconstrained locomotion in rats and mice. Approach. We interfaced a large-scale robotic structure actuated in four degrees of freedom to exchangeable attachment modules exhibiting selective compliance along distinct directions. This combination allowed high-precision force and torque control in multiple directions over a large workspace. We next designed a neurorobotic platform wherein real-time kinematics and physiological signals directly adjust robotic actuation and prosthetic actions. We tested the performance of this platform in both rats and mice with spinal cord injury. Main Results. Kinematic analyses showed that the robotic interface did not impede locomotor movements of lightweight mice that walked freely along paths with changing directions and height profiles. Personalized trunk assistance instantly enabled coordinated locomotion in mice and rats with severe hindlimb motor deficits. Closed-loop control of robotic actuation based on ongoing movement features enabled real-time control of electromyographic activity in anti-gravity muscles during locomotion. Significance. This neurorobotic platform will support the study of the mechanisms underlying the therapeutic effects of locomotor prosthetics and rehabilitation using high-resolution genetic tools in rodent models.

A neurorobotic platform for locomotor prosthetic development in rats and mice.

PubMed

von Zitzewitz, Joachim; Asboth, Leonie; Fumeaux, Nicolas; Hasse, Alexander; Baud, Laetitia; Vallery, Heike; Courtine, Grégoire

2016-04-01

We aimed to develop a robotic interface capable of providing finely-tuned, multidirectional trunk assistance adjusted in real-time during unconstrained locomotion in rats and mice. We interfaced a large-scale robotic structure actuated in four degrees of freedom to exchangeable attachment modules exhibiting selective compliance along distinct directions. This combination allowed high-precision force and torque control in multiple directions over a large workspace. We next designed a neurorobotic platform wherein real-time kinematics and physiological signals directly adjust robotic actuation and prosthetic actions. We tested the performance of this platform in both rats and mice with spinal cord injury. Kinematic analyses showed that the robotic interface did not impede locomotor movements of lightweight mice that walked freely along paths with changing directions and height profiles. Personalized trunk assistance instantly enabled coordinated locomotion in mice and rats with severe hindlimb motor deficits. Closed-loop control of robotic actuation based on ongoing movement features enabled real-time control of electromyographic activity in anti-gravity muscles during locomotion. This neurorobotic platform will support the study of the mechanisms underlying the therapeutic effects of locomotor prosthetics and rehabilitation using high-resolution genetic tools in rodent models.

Carbon Coated Boron Nitride Nanosheets for Polymer Nanocomposites with Enhanced Dielectric Performance

PubMed Central

Yang, Minhao; Zhao, Hang; He, Delong; Hu, Chaohe; Chen, Haowei; Bai, Jinbo

2017-01-01

Carbon coated boron nitride nanosheets (BNNSs@C) hybrids with different carbon contents were synthesized by a chemical vapor deposition (CVD) method. The content of carbon in as-obtained BNNSs@C hybrids could be precisely adjusted from 2.50% to 22.62% by controlling the carbon deposition time during the CVD procedure. Afterward, the BNNSs@C hybrids were subsequently incorporated into the polyvinylidene fluoride (PVDF) matrix to fabricate the BNNSs@C/PVDF nanocomposites through a combination of solution and melting blending methods. The dielectric properties of the as-obtained BNNSs@C/PVDF nanocomposites could be accurately tuned by adjusting the carbon content. The resultant nanocomposites could afford a high dielectric constant about 39 (103 Hz) at BNNSs@C hybrids loading of 30 vol %, which is 4.8 times larger than that of pristine BNNSs-filled ones at the same filler loading, and 3.5 times higher than that of pure PVDF matrix. The largely enhanced dielectric performance could be ascribed to the improved interfacial polarizations of BNNSs/carbon and carbon/PVDF interfaces. The approach reported here offers an effective and alternative method to fabricate high-performance dielectric nanocomposites, which could be potentially applied to the embedded capacitors with high dielectric performance. PMID:28773105

The effects of compressibility on the GIA in southeast Alaska

NASA Astrophysics Data System (ADS)

Tanaka, Yoshiyuki; Sato, Tadahiro; Ohta, Yusaku; Miura, Satoshi; Freymueller, Jeffrey T.; Klemann, Volker

2015-03-01

Recent theoretical simulations on the glacial isostatic adjustment (GIA) have revealed that the model differences arising from considering mantle compressibility are not necessarily negligible if compared with the observation accuracy of present-day deformation rates. In this study, a compressible model is constructed for the GIA in southeast Alaska, and the uplift rate is compared with GPS data and the incompressible case for the first time. It is shown that, for Maxwell rheology, the incompressible model potentially underestimates the mean uplift rate by approximately 27% (4 mm/yr) with respect to the compressible case and the difference is detectable given observational precision. This difference between the compressible and incompressible models is reduced to 10% by matching the flexural rigidity of both earth models. When carrying out an inversion using incompressible models, this adjustment is important to infer a physically more correct viscoelastic structure.

Research on flight stability performance of rotor aircraft based on visual servo control method

NASA Astrophysics Data System (ADS)

Yu, Yanan; Chen, Jing

2016-11-01

control method based on visual servo feedback is proposed, which is used to improve the attitude of a quad-rotor aircraft and to enhance its flight stability. Ground target images are obtained by a visual platform fixed on aircraft. Scale invariant feature transform (SIFT) algorism is used to extract image feature information. According to the image characteristic analysis, fast motion estimation is completed and used as an input signal of PID flight control system to realize real-time status adjustment in flight process. Imaging tests and simulation results show that the method proposed acts good performance in terms of flight stability compensation and attitude adjustment. The response speed and control precision meets the requirements of actual use, which is able to reduce or even eliminate the influence of environmental disturbance. So the method proposed has certain research value to solve the problem of aircraft's anti-disturbance.

Basic research for the geodynamics program

NASA Technical Reports Server (NTRS)

Mueller, Ivan I.

1988-01-01

Additional results are presented concerning a study that considers improvements over present Earth Rotation Parameter (ERP) determination methods by directly combining observations from various space geodetic systems in one adjustment. Earlier results are extended, showing that in addition to slight improvements in accuracy, substantial (a factor of three or more) improvements in precision and significant reductions in correlations between various parameters can be obtained (by combining Lunar Laser Ranging - LLR, Satellite Laser Ranging - SLR to Lageos, and Very Long Baseline Interferometry - VLBI data in one adjustment) as compared to results from individual systems. Smaller improvements are also seen over the weighted means of the individual system results. Although data transmission would not be significantly reduced, negligible additional computer time would be required if (standardized) normal equations were available from individual solutions. Suggestions for future work and implications for the New Earth Rotation Service (IERS) are also presented.

An intelligent FFR with a self-adjustable ventilation fan.

PubMed

Zhou, Song; Li, Hui; Shen, Shengnan; Li, Siyu; Wang, Wei; Zhang, Xiaotie; Yang, James

2017-11-01

This article presents an intelligent Filtering Facepiece Respirator (FFR) with a self-adjustable ventilation fan for improved comfort. The ventilation fan with an intelligent control aims to reduce temperature, relative humidity, and CO 2 concentrations inside the facepiece. Compared with a previous version of the FFR, the advantage of this new FFR is the intelligent control of the fan's rotation speed based on the change in temperature and relative humidity in the FFR dead space. The design of the control system utilizes an 8-bit, ultra-low power STC15W404AS microcontroller (HongJin technology, Shenzhen, China), and adopts a high-precision AM2320 device (AoSong electronic, Guangzhou, China) as temperature and relative humidity sensor so that control of temperature and relative humidity is realized in real time within the FFR dead space. The ventilation fan is intelligently driven and runs on a rechargeable lithium battery with a power-save mode that provides a correspondingly longer operational time. Meanwhile, the design is simplistic. Two experiments were performed to determine the best location to place the fan.

A new supervised learning algorithm for spiking neurons.

PubMed

Xu, Yan; Zeng, Xiaoqin; Zhong, Shuiming

2013-06-01

The purpose of supervised learning with temporal encoding for spiking neurons is to make the neurons emit a specific spike train encoded by the precise firing times of spikes. If only running time is considered, the supervised learning for a spiking neuron is equivalent to distinguishing the times of desired output spikes and the other time during the running process of the neuron through adjusting synaptic weights, which can be regarded as a classification problem. Based on this idea, this letter proposes a new supervised learning method for spiking neurons with temporal encoding; it first transforms the supervised learning into a classification problem and then solves the problem by using the perceptron learning rule. The experiment results show that the proposed method has higher learning accuracy and efficiency over the existing learning methods, so it is more powerful for solving complex and real-time problems.

All chain Loran-C time synchronization

NASA Technical Reports Server (NTRS)

Sherman, H. T.

1973-01-01

A program is in progress to implement coordinated universal time (UTC) synchronization on all Loran-C transmissions. The present capability is limited to five Loran-C chains in which the tolerance is twenty-five microseconds with respect to UTC. Upon completion of the program, the transmissions of all Loran-C chains will be maintained within five microseconds of UTC. The improvement plan consists of equipping selected Loran-C transmitting stations for greater precision of frequency standard adjustment and improved monitoring capability. External time monitor stations will utilize television time transfer techniques with nearby SATCOM terminals where practicable, thus providing the requisite traceability to the Naval Observatory. The monitor equipment groups and the interrelationships with the ground station equipment are discussed. After a brief review of control doctrine, forth-coming improvements to transmitting stations and how the time monitor and navigation equipments will complement each other resulting in improved service to all users of the Loran-C system are described.

Accounting for failures may improve precision: evidence supporting improved validity of self-reported condom use.

PubMed

Crosby, Richard; Salazar, Laura F; DiClemente, Ralph J; Yarber, William L; Caliendo, Angela M; Staples-Horne, Michelle

2005-08-01

To determine whether a measure of unprotected vaginal sex that is adjusted for condom failures would produce improved accuracy in predicting biologically confirmed STDs (chlamydia and gonorrhea) among female teens. Self-reported measures were collected using audio-computer-assisted self-interviewing. DNA amplification for the presence of Chlamydia trachomatis and Neisseria gonorrhoeae was conducted. The unadjusted measure of unprotected vaginal sex was not significantly associated with biologically confirmed prevalence of STDs (prevalence ratio [PR] = 1.51; 95% CI = 0.71-3.21; P = 0.28). Alternatively, the adjusted measure achieved significance (PR = 3.59; 95% CI = 1.13-11.38; P = 0.014). More than one quarter (25.6%) of teens using condoms inconsistently and/or incorrectly tested positive for an STD compared to 7.1% among those reporting the consistent and correct use of condoms. Findings demonstrate that studies of condom effectiveness should use an adjusted measure of condom use to achieve precision and rigor.

Nonlinear effects in the time measurement device based on surface acoustic wave filter excitation.

PubMed

Prochazka, Ivan; Panek, Petr

2009-07-01

A transversal surface acoustic wave filter has been used as a time interpolator in a time interval measurement device. We are presenting the experiments and results of an analysis of the nonlinear effects in such a time interpolator. The analysis shows that the nonlinear distortion in the time interpolator circuits causes a deterministic measurement error which can be understood as the time interpolation nonlinearity. The dependence of this error on time of the measured events can be expressed as a sparse Fourier series thus it usually oscillates very quickly in comparison to the clock period. The theoretical model is in good agreement with experiments carried out on an experimental two-channel timing system. Using highly linear amplifiers in the time interpolator and adjusting the filter excitation level to the optimum, we have achieved the interpolation nonlinearity below 0.2 ps. The overall single-shot precision of the experimental timing device is 0.9 ps rms in each channel.

Design of New Muzzle for 80mm Diamter Single-Stage Gas Gun

NASA Astrophysics Data System (ADS)

Russell, R. T.; Starks, K. S.; Grote, D. L., II; Vandersall, K. S.; Zhou, M.; Thadhani, N. N.

1999-06-01

In this paper, we describe the design of a new muzzle for the Georgia Institute of Technology's 80mm diameter single-stage gas gun. The muzzle is designed to accommodate both normal and inclined impact experiments. Modular target-holding assemblies are mounted on a hardened tool steel annular plate 3 inches in thickness and 15 inches in diameter. This plate is threaded on to the gun barrel and locked into place by an anti-backlash assembly to prevent loss of alignment. The target mount for normal impact experiments consists of two 4.5 inch diameter semi-cylindrical ring sections with surfaces lapped perpendicular to the major bore axis. The inclined target mount includes a pair of concentric cylinder sections with an inner diameter of 8 inches. Tilt adjustment is achieved around two mutually perpendicular and intersecting axis of rotation, as in a gimbals assembly. Coarse alignment allows for angles between -10 and +30 degrees. Fine alignment is achieved using 3/8 inch machine screws with 40 threads per inch. This mechanism yields a precision of 0.025 inches per revolution, the same precision found in a micrometer. The linear distance between the adjustment mechanisms and the axes of rotation geometrically enhances fine alignment. Velocity measurement assemblies using shear pins, time of arrival pins, and laser/photo-diode circuits are designed as bolt-on modules.

Closed-Loop Control System for Friction Stir Welding Retractable Pin Tool

NASA Technical Reports Server (NTRS)

Ding, R. Jeffrey; Romine, Peter L.; Munafo, Paul M. (Technical Monitor)

2001-01-01

NASA invention disclosure, NASA Case No. MFS-31413, entitled "System for Controlling the Stirring Pin of a Friction Stir Welding Apparatus", (Patent Pending) authored by Jeff Ding, Dr Peter Romine and Pete Oelgoetz, addresses the precision control of the friction stir welding process. The closed-loop control system automatically adjusts the spinning welding pin, real-time, to maintain a precise penetration ligament (i.e., distance between pin-tip and weld panel backside surface). A specific pin length can be maintained while welding constant thickness or tapered material thickness weld panels. The closed-loop control system provides operator data and information relative to the exact position of the welding pin inside the weld joint. This paper presents the closed-loop RPT control system that operates using the auto-feedback of force signals sensed by the tip and shoulder of the welding pin. Significance: The FSW process can be successfully used in a production environment only if there is a method or technique that informs the FSW operator the precise location of the welding pin inside the weld joint. This is essential for applications in aerospace, automotive, pressure vessel, commercial aircraft and other industries.

Automation of a Nile red staining assay enables high throughput quantification of microalgal lipid production.

PubMed

Morschett, Holger; Wiechert, Wolfgang; Oldiges, Marco

2016-02-09

Within the context of microalgal lipid production for biofuels and bulk chemical applications, specialized higher throughput devices for small scale parallelized cultivation are expected to boost the time efficiency of phototrophic bioprocess development. However, the increasing number of possible experiments is directly coupled to the demand for lipid quantification protocols that enable reliably measuring large sets of samples within short time and that can deal with the reduced sample volume typically generated at screening scale. To meet these demands, a dye based assay was established using a liquid handling robot to provide reproducible high throughput quantification of lipids with minimized hands-on-time. Lipid production was monitored using the fluorescent dye Nile red with dimethyl sulfoxide as solvent facilitating dye permeation. The staining kinetics of cells at different concentrations and physiological states were investigated to successfully down-scale the assay to 96 well microtiter plates. Gravimetric calibration against a well-established extractive protocol enabled absolute quantification of intracellular lipids improving precision from ±8 to ±2 % on average. Implementation into an automated liquid handling platform allows for measuring up to 48 samples within 6.5 h, reducing hands-on-time to a third compared to manual operation. Moreover, it was shown that automation enhances accuracy and precision compared to manual preparation. It was revealed that established protocols relying on optical density or cell number for biomass adjustion prior to staining may suffer from errors due to significant changes of the cells' optical and physiological properties during cultivation. Alternatively, the biovolume was used as a measure for biomass concentration so that errors from morphological changes can be excluded. The newly established assay proved to be applicable for absolute quantification of algal lipids avoiding limitations of currently established protocols, namely biomass adjustment and limited throughput. Automation was shown to improve data reliability, as well as experimental throughput simultaneously minimizing the needed hands-on-time to a third. Thereby, the presented protocol meets the demands for the analysis of samples generated by the upcoming generation of devices for higher throughput phototrophic cultivation and thereby contributes to boosting the time efficiency for setting up algae lipid production processes.

Kinematic precision of gear trains

NASA Technical Reports Server (NTRS)

Litvin, F. L.; Goldrich, R. N.; Coy, J. J.; Zaretsky, E. V.

1983-01-01

Kinematic precision is affected by errors which are the result of either intentional adjustments or accidental defects in manufacturing and assembly of gear trains. A method for the determination of kinematic precision of gear trains is described. The method is based on the exact kinematic relations for the contact point motions of the gear tooth surfaces under the influence of errors. An approximate method is also explained. Example applications of the general approximate methods are demonstrated for gear trains consisting of involute (spur and helical) gears, circular arc (Wildhaber-Novikov) gears, and spiral bevel gears. Gear noise measurements from a helicopter transmission are presented and discussed with relation to the kinematic precision theory. Previously announced in STAR as N82-32733

Direction information in multiple object tracking is limited by a graded resource.

PubMed

Horowitz, Todd S; Cohen, Michael A

2010-10-01

Is multiple object tracking (MOT) limited by a fixed set of structures (slots), a limited but divisible resource, or both? Here, we answer this question by measuring the precision of the direction representation for tracked targets. The signature of a limited resource is a decrease in precision as the square root of the tracking load. The signature of fixed slots is a fixed precision. Hybrid models predict a rapid decrease to asymptotic precision. In two experiments, observers tracked moving disks and reported target motion direction by adjusting a probe arrow. We derived the precision of representation of correctly tracked targets using a mixture distribution analysis. Precision declined with target load according to the square-root law up to six targets. This finding is inconsistent with both pure and hybrid slot models. Instead, directional information in MOT appears to be limited by a continuously divisible resource.

Impact of orbit modeling on DORIS station position and Earth rotation estimates

NASA Astrophysics Data System (ADS)

Štěpánek, Petr; Rodriguez-Solano, Carlos Javier; Hugentobler, Urs; Filler, Vratislav

2014-04-01

The high precision of estimated station coordinates and Earth rotation parameters (ERP) obtained from satellite geodetic techniques is based on the precise determination of the satellite orbit. This paper focuses on the analysis of the impact of different orbit parameterizations on the accuracy of station coordinates and the ERPs derived from DORIS observations. In a series of experiments the DORIS data from the complete year 2011 were processed with different orbit model settings. First, the impact of precise modeling of the non-conservative forces on geodetic parameters was compared with results obtained with an empirical-stochastic modeling approach. Second, the temporal spacing of drag scaling parameters was tested. Third, the impact of estimating once-per-revolution harmonic accelerations in cross-track direction was analyzed. And fourth, two different approaches for solar radiation pressure (SRP) handling were compared, namely adjusting SRP scaling parameter or fixing it on pre-defined values. Our analyses confirm that the empirical-stochastic orbit modeling approach, which does not require satellite attitude information and macro models, results for most of the monitored station parameters in comparable accuracy as the dynamical model that employs precise non-conservative force modeling. However, the dynamical orbit model leads to a reduction of the RMS values for the estimated rotation pole coordinates by 17% for x-pole and 12% for y-pole. The experiments show that adjusting atmospheric drag scaling parameters each 30 min is appropriate for DORIS solutions. Moreover, it was shown that the adjustment of cross-track once-per-revolution empirical parameter increases the RMS of the estimated Earth rotation pole coordinates. With recent data it was however not possible to confirm the previously known high annual variation in the estimated geocenter z-translation series as well as its mitigation by fixing the SRP parameters on pre-defined values.

Fixed point theorems of GPS carrier phase ambiguity resolution and their application to massive network processing: Ambizap

NASA Astrophysics Data System (ADS)

Blewitt, Geoffrey

2008-12-01

Precise point positioning (PPP) has become popular for Global Positioning System (GPS) geodetic network analysis because for n stations, PPP has O(n) processing time, yet solutions closely approximate those of O(n3) full network analysis. Subsequent carrier phase ambiguity resolution (AR) further improves PPP precision and accuracy; however, full-network bootstrapping AR algorithms are O(n4), limiting single network solutions to n < 100. In this contribution, fixed point theorems of AR are derived and then used to develop "Ambizap," an O(n) algorithm designed to give results that closely approximate full network AR. Ambizap has been tested to n ≈ 2800 and proves to be O(n) in this range, adding only ˜50% to PPP processing time. Tests show that a 98-station network is resolved on a 3-GHz CPU in 7 min, versus 22 h using O(n4) AR methods. Ambizap features a novel network adjustment filter, producing solutions that precisely match O(n4) full network analysis. The resulting coordinates agree to ≪1 mm with current AR methods, much smaller than the ˜3-mm RMS precision of PPP alone. A 2000-station global network can be ambiguity resolved in ˜2.5 h. Together with PPP, Ambizap enables rapid, multiple reanalysis of large networks (e.g., ˜1000-station EarthScope Plate Boundary Observatory) and facilitates the addition of extra stations to an existing network solution without need to reprocess all data. To meet future needs, PPP plus Ambizap is designed to handle ˜10,000 stations per day on a 3-GHz dual-CPU desktop PC.

Prediction Study on Anti-Slide Control of Railway Vehicle Based on RBF Neural Networks

NASA Astrophysics Data System (ADS)

Yang, Lijun; Zhang, Jimin

While railway vehicle braking, Anti-slide control system will detect operating status of each wheel-sets e.g. speed difference and deceleration etc. Once the detected value on some wheel-set is over pre-defined threshold, brake effort on such wheel-set will be adjusted automatically to avoid blocking. Such method takes effect on guarantee safety operation of vehicle and avoid wheel-set flatness, however it cannot adapt itself to the rail adhesion variation. While wheel-sets slide, the operating status is chaotic time series with certain law, and can be predicted with the law and experiment data in certain time. The predicted values can be used as the input reference signals of vehicle anti-slide control system, to judge and control the slide status of wheel-sets. In this article, the RBF neural networks is taken to predict wheel-set slide status in multi-step with weight vector adjusted based on online self-adaptive algorithm, and the center & normalizing parameters of active function of the hidden unit of RBF neural networks' hidden layer computed with K-means clustering algorithm. With multi-step prediction simulation, the predicted signal with appropriate precision can be used by anti-slide system to trace actively and adjust wheel-set slide tendency, so as to adapt to wheel-rail adhesion variation and reduce the risk of wheel-set blocking.

Field precision machining technology of target chamber in ICF lasers

NASA Astrophysics Data System (ADS)

Xu, Yuanli; Wu, Wenkai; Shi, Sucun; Duan, Lin; Chen, Gang; Wang, Baoxu; Song, Yugang; Liu, Huilin; Zhu, Mingzhi

2016-10-01

In ICF lasers, many independent laser beams are required to be positioned on target with a very high degree of accuracy during a shot. The target chamber provides a precision platform and datum reference for final optics assembly and target collimation and location system. The target chamber consists of shell with welded flanges, reinforced concrete pedestal, and lateral support structure. The field precision machining technology of target chamber in ICF lasers have been developed based on ShenGuangIII (SGIII). The same center of the target chamber is adopted in the process of design, fabrication, and alignment. The technologies of beam collimation and datum reference transformation are developed for the fabrication, positioning and adjustment of target chamber. A supporting and rotating mechanism and a special drilling machine are developed to bore the holes of ports. An adjustment mechanism is designed to accurately position the target chamber. In order to ensure the collimation requirements of the beam leading and focusing and the target positioning, custom-machined spacers are used to accurately correct the alignment error of the ports. Finally, this paper describes the chamber center, orientation, and centering alignment error measurements of SGIII. The measurements show the field precision machining of SGIII target chamber meet its design requirement. These information can be used on similar systems.

A 45 ps time digitizer with a two-phase clock and dual-edge two-stage interpolation in a field programmable gate array device

NASA Astrophysics Data System (ADS)

Szplet, R.; Kalisz, J.; Jachna, Z.

2009-02-01

We present a time digitizer having 45 ps resolution, integrated in a field programmable gate array (FPGA) device. The time interval measurement is based on the two-stage interpolation method. A dual-edge two-phase interpolator is driven by the on-chip synthesized 250 MHz clock with precise phase adjustment. An improved dual-edge double synchronizer was developed to control the main counter. The nonlinearity of the digitizer's transfer characteristic is identified and utilized by the dedicated hardware code processor for the on-the-fly correction of the output data. Application of presented ideas has resulted in the measurement uncertainty of the digitizer below 70 ps RMS over the time interval ranging from 0 to 1 s. The use of the two-stage interpolation and a fast FIFO memory has allowed us to obtain the maximum measurement rate of five million measurements per second.

Laser-Ranging Transponders for Science Investigations of the Moon and Mars

NASA Technical Reports Server (NTRS)

Hemmati, Hamid; Chen, Yijiang; Bimbaum, Kevin

2012-01-01

An active laser was developed ranging in real-time with two terminals, emulating interplanetary distances, and with submillimeter accuracy. In order to overcome the limitations to ranging accuracy from jitters and delay drifts within the transponders, architecture was proposed based on asynchronous paired one-way ranging with local references. A portion of the transmitted light is directed, via a reference path, to the local detector. This allows for compensation of any jitter in the timing of the emitted laser pulse. The same detector is used to measure the time of the received pulses emitted from the remote terminal. This approach removes any change in the delay caused by the detector or its electronics. Two separate terminals using commercial off-the-shelf hardware were built to emulate active laser ranging over interplanetary distances. The communication link for the command to start recording pulse arrival times and data transfer from one terminal to the other was achieved using a standard wireless link, emulating free space laser communication. The deviation is well below the goal of 1-mm precision. This leaves enough margin to achieve 1-mm precision when including the fluctuations due to atmospheric turbulence while ranging to Mars through the Earth s atmosphere. The two terminals are mounted on translation stages, which can be moved freely on rails to yield a wide range of distances with fine adjustment. The two terminals were separated by approximately 16 meters.

Design of a short nonuniform acquisition protocol for quantitative analysis in dynamic cardiac SPECT imaging - a retrospective 123 I-MIBG animal study.

PubMed

Zan, Yunlong; Long, Yong; Chen, Kewei; Li, Biao; Huang, Qiu; Gullberg, Grant T

2017-07-01

Our previous works have found that quantitative analysis of 123 I-MIBG kinetics in the rat heart with dynamic single-photon emission computed tomography (SPECT) offers the potential to quantify the innervation integrity at an early stage of left ventricular hypertrophy. However, conventional protocols involving a long acquisition time for dynamic imaging reduce the animal survival rate and thus make longitudinal analysis difficult. The goal of this work was to develop a procedure to reduce the total acquisition time by selecting nonuniform acquisition times for projection views while maintaining the accuracy and precision of estimated physiologic parameters. Taking dynamic cardiac imaging with 123 I-MIBG in rats as an example, we generated time activity curves (TACs) of regions of interest (ROIs) as ground truths based on a direct four-dimensional reconstruction of experimental data acquired from a rotating SPECT camera, where TACs represented as the coefficients of B-spline basis functions were used to estimate compartmental model parameters. By iteratively adjusting the knots (i.e., control points) of B-spline basis functions, new TACs were created according to two rules: accuracy and precision. The accuracy criterion allocates the knots to achieve low relative entropy between the estimated left ventricular blood pool TAC and its ground truth so that the estimated input function approximates its real value and thus the procedure yields an accurate estimate of model parameters. The precision criterion, via the D-optimal method, forces the estimated parameters to be as precise as possible, with minimum variances. Based on the final knots obtained, a new protocol of 30 min was built with a shorter acquisition time that maintained a 5% error in estimating rate constants of the compartment model. This was evaluated through digital simulations. The simulation results showed that our method was able to reduce the acquisition time from 100 to 30 min for the cardiac study of rats with 123 I-MIBG. Compared to a uniform interval dynamic SPECT protocol (1 s acquisition interval, 30 min acquisition time), the newly proposed protocol with nonuniform interval achieved comparable (K1 and k2, P = 0.5745 for K1 and P = 0.0604 for k2) or better (Distribution Volume, DV, P = 0.0004) performance for parameter estimates with less storage and shorter computational time. In this study, a procedure was devised to shorten the acquisition time while maintaining the accuracy and precision of estimated physiologic parameters in dynamic SPECT imaging. The procedure was designed for 123 I-MIBG cardiac imaging in rat studies; however, it has the potential to be extended to other applications, including patient studies involving the acquisition of dynamic SPECT data. © 2017 American Association of Physicists in Medicine.

LOD estimation from DORIS observations

NASA Astrophysics Data System (ADS)

Stepanek, Petr; Filler, Vratislav; Buday, Michal; Hugentobler, Urs

2016-04-01

The difference between astronomically determined duration of the day and 86400 seconds is called length of day (LOD). The LOD could be also understood as the daily rate of the difference between the Universal Time UT1, based on the Earth rotation, and the International Atomic Time TAI. The LOD is estimated using various Satellite Geodesy techniques as GNSS and SLR, while absolute UT1-TAI difference is precisely determined by VLBI. Contrary to other IERS techniques, the LOD estimation using DORIS (Doppler Orbitography and Radiopositioning Integrated by satellite) measurement did not achieve a geodetic accuracy in the past, reaching the precision at the level of several ms per day. However, recent experiments performed by IDS (International DORIS Service) analysis centre at Geodetic Observatory Pecny show a possibility to reach accuracy around 0.1 ms per day, when not adjusting the cross-track harmonics in the Satellite orbit model. The paper presents the long term LOD series determined from the DORIS solutions. The series are compared with C04 as the reference. Results are discussed in the context of accuracy achieved with GNSS and SLR. Besides the multi-satellite DORIS solutions, also the LOD series from the individual DORIS satellite solutions are analysed.

The research of automatic speed control algorithm based on Green CBTC

NASA Astrophysics Data System (ADS)

Lin, Ying; Xiong, Hui; Wang, Xiaoliang; Wu, Youyou; Zhang, Chuanqi

2017-06-01

Automatic speed control algorithm is one of the core technologies of train operation control system. It’s a typical multi-objective optimization control algorithm, which achieve the train speed control for timing, comfort, energy-saving and precise parking. At present, the train speed automatic control technology is widely used in metro and inter-city railways. It has been found that the automatic speed control technology can effectively reduce the driver’s intensity, and improve the operation quality. However, the current used algorithm is poor at energy-saving, even not as good as manual driving. In order to solve the problem of energy-saving, this paper proposes an automatic speed control algorithm based on Green CBTC system. Based on the Green CBTC system, the algorithm can adjust the operation status of the train to improve the efficient using rate of regenerative braking feedback energy while ensuring the timing, comfort and precise parking targets. Due to the reason, the energy-using of Green CBTC system is lower than traditional CBTC system. The simulation results show that the algorithm based on Green CBTC system can effectively reduce the energy-using due to the improvement of the using rate of regenerative braking feedback energy.

Robust adhesive precision bonding in automated assembly cells

NASA Astrophysics Data System (ADS)

Müller, Tobias; Haag, Sebastian; Bastuck, Thomas; Gisler, Thomas; Moser, Hansruedi; Uusimaa, Petteri; Axt, Christoph; Brecher, Christian

2014-03-01

Diode lasers are gaining importance, making their way to higher output powers along with improved BPP. The assembly of micro-optics for diode laser systems goes along with the highest requirements regarding assembly precision. Assembly costs for micro-optics are driven by the requirements regarding alignment in a submicron and the corresponding challenges induced by adhesive bonding. For micro-optic assembly tasks a major challenge in adhesive bonding at highest precision level is the fact, that the bonding process is irreversible. Accordingly, the first bonding attempt needs to be successful. Today's UV-curing adhesives inherit shrinkage effects crucial for submicron tolerances of e.g. FACs. The impact of the shrinkage effects can be tackled by a suitable bonding area design, such as minimal adhesive gaps and an adapted shrinkage offset value for the specific assembly parameters. Compensating shrinkage effects is difficult, as the shrinkage of UV-curing adhesives is not constant between two different lots and varies even over the storage period even under ideal circumstances as first test results indicate. An up-to-date characterization of the adhesive appears necessary for maximum precision in optics assembly to reach highest output yields, minimal tolerances and ideal beamshaping results. Therefore, a measurement setup to precisely determine the up-to-date level of shrinkage has been setup. The goal is to provide necessary information on current shrinkage to the operator or assembly cell to adjust the compensation offset on a daily basis. Impacts of this information are expected to be an improved beam shaping result and a first-time-right production.

Precision-controlled elution of a 82Sr/82Rb generator for cardiac perfusion imaging with positron emission tomography

NASA Astrophysics Data System (ADS)

Klein, R.; Adler, A.; Beanlands, R. S.; de Kemp, R. A.

2007-02-01

A rubidium-82 (82Rb) elution system is described for use with positron emission tomography. Due to the short half-life of 82Rb (76 s), the system physics must be modelled precisely to account for transport delay and the associated activity decay and dispersion. Saline flow is switched between a 82Sr/82Rb generator and a bypass line to achieve a constant-activity elution of 82Rb. Pulse width modulation (PWM) of a solenoid valve is compared to simple threshold control as a means to simulate a proportional valve. A predictive-corrective control (PCC) algorithm is developed which produces a constant-activity elution within the constraints of long feedback delay and short elution time. The system model parameters are adjusted through a self-tuning algorithm to minimize error versus the requested time-activity profile. The system is self-calibrating with 2.5% repeatability, independent of generator activity and elution flow rate. Accurate 30 s constant-activity elutions of 10-70% of the total generator activity are achieved using both control methods. The combined PWM-PCC method provides significant improvement in precision and accuracy of the requested elution profiles. The 82Rb elution system produces accurate and reproducible constant-activity elution profiles of 82Rb activity, independent of parent 82Sr activity in the generator. More reproducible elution profiles may improve the quality of clinical and research PET perfusion studies using 82Rb.

Precision-controlled elution of a 82Sr/82Rb generator for cardiac perfusion imaging with positron emission tomography.

PubMed

Klein, R; Adler, A; Beanlands, R S; Dekemp, R A

2007-02-07

A rubidium-82 ((82)Rb) elution system is described for use with positron emission tomography. Due to the short half-life of (82)Rb (76 s), the system physics must be modelled precisely to account for transport delay and the associated activity decay and dispersion. Saline flow is switched between a (82)Sr/(82)Rb generator and a bypass line to achieve a constant-activity elution of (82)Rb. Pulse width modulation (PWM) of a solenoid valve is compared to simple threshold control as a means to simulate a proportional valve. A predictive-corrective control (PCC) algorithm is developed which produces a constant-activity elution within the constraints of long feedback delay and short elution time. The system model parameters are adjusted through a self-tuning algorithm to minimize error versus the requested time-activity profile. The system is self-calibrating with 2.5% repeatability, independent of generator activity and elution flow rate. Accurate 30 s constant-activity elutions of 10-70% of the total generator activity are achieved using both control methods. The combined PWM-PCC method provides significant improvement in precision and accuracy of the requested elution profiles. The (82)Rb elution system produces accurate and reproducible constant-activity elution profiles of (82)Rb activity, independent of parent (82)Sr activity in the generator. More reproducible elution profiles may improve the quality of clinical and research PET perfusion studies using (82)Rb.

Femtosecond profiling of shaped x-ray pulses

NASA Astrophysics Data System (ADS)

Hoffmann, M. C.; Grguraš, I.; Behrens, C.; Bostedt, C.; Bozek, J.; Bromberger, H.; Coffee, R.; Costello, J. T.; DiMauro, L. F.; Ding, Y.; Doumy, G.; Helml, W.; Ilchen, M.; Kienberger, R.; Lee, S.; Maier, A. R.; Mazza, T.; Meyer, M.; Messerschmidt, M.; Schorb, S.; Schweinberger, W.; Zhang, K.; Cavalieri, A. L.

2018-03-01

Arbitrary manipulation of the temporal and spectral properties of x-ray pulses at free-electron lasers would revolutionize many experimental applications. At the Linac Coherent Light Source at Stanford National Accelerator Laboratory, the momentum phase-space of the free-electron laser driving electron bunch can be tuned to emit a pair of x-ray pulses with independently variable photon energy and femtosecond delay. However, while accelerator parameters can easily be adjusted to tune the electron bunch phase-space, the final impact of these actuators on the x-ray pulse cannot be predicted with sufficient precision. Furthermore, shot-to-shot instabilities that distort the pulse shape unpredictably cannot be fully suppressed. Therefore, the ability to directly characterize the x-rays is essential to ensure precise and consistent control. In this work, we have generated x-ray pulse pairs via electron bunch shaping and characterized them on a single-shot basis with femtosecond resolution through time-resolved photoelectron streaking spectroscopy. This achievement completes an important step toward future x-ray pulse shaping techniques.

Space Technology 7 : Micropropulsion and Mass Distribution

NASA Technical Reports Server (NTRS)

Carnaub, A.; Dunn, C.; Ziemer, J,; Hruby, V.; Spence, D.; Demmons, N.; Roy, T.; McCormick, R.; Gasaska, C.; Young, J.;

Incorporation of habitat information in the development of indices of larval bluefin tuna (Thunnus thynnus) in the Western Mediterranean Sea (2001-2005 and 2012-2013)

NASA Astrophysics Data System (ADS)

Ingram, G. Walter; Alvarez-Berastegui, Diego; Reglero, Patricia; Balbín, Rosa; García, Alberto; Alemany, Francisco

2017-06-01

Fishery independent indices of bluefin tuna larvae in the Western Mediterranean Sea are presented utilizing ichthyoplankton survey data collected from 2001 through 2005 and 2012 through 2013. Indices were developed using larval catch rates collected using two different types of bongo sampling, by first standardizing catch rates by gear/fishing-style and then employing a delta-lognormal modeling approach. The delta-lognormal models were developed three ways: 1) a basic larval index including the following covariates: time of day, a systematic geographic area variable, month and year; 2) a standard environmental larval index including the following covariates: mean water temperature over the mixed layer depth, mean salinity over the mixed layer depth, geostrophic velocity, time of day, a systematic geographic area variable, month and year; and 3) a habitat-adjusted larval index including the following covariates: a potential habitat variable, time of day, a systematic geographic area variable, month and year. Results indicated that all three model-types had similar precision in index values. However, the habitat-adjusted larval index demonstrated a high correlation with estimates of spawning stock biomass from the previous stock assessment model, and, therefore, is recommended as a tuning index in future stock assessment models.

An online supervised learning method based on gradient descent for spiking neurons.

PubMed

Xu, Yan; Yang, Jing; Zhong, Shuiming

2017-09-01

The purpose of supervised learning with temporal encoding for spiking neurons is to make the neurons emit a specific spike train encoded by precise firing times of spikes. The gradient-descent-based (GDB) learning methods are widely used and verified in the current research. Although the existing GDB multi-spike learning (or spike sequence learning) methods have good performance, they work in an offline manner and still have some limitations. This paper proposes an online GDB spike sequence learning method for spiking neurons that is based on the online adjustment mechanism of real biological neuron synapses. The method constructs error function and calculates the adjustment of synaptic weights as soon as the neurons emit a spike during their running process. We analyze and synthesize desired and actual output spikes to select appropriate input spikes in the calculation of weight adjustment in this paper. The experimental results show that our method obviously improves learning performance compared with the offline learning manner and has certain advantage on learning accuracy compared with other learning methods. Stronger learning ability determines that the method has large pattern storage capacity. Copyright © 2017 Elsevier Ltd. All rights reserved.

Bonneville, Power Administration Timing System

NASA Technical Reports Server (NTRS)

Martin, Kenneth E.

1996-01-01

Time is an integral part of the Bonneville Power Administration's (BPA) operational systems. Generation and power transfers are planned in advance. Utilities coordinate with each other by making these adjustments on a timed schedule. Price varies with demand, so billing is based on time. Outages for maintenance are scheduled to assure they do not interrupt reliable power delivery. Disturbance records are aligned with recorded timetags for analysis and comparison with related information. Advanced applications like traveling wave fault location and real-time phase measurement require continuous timing with high precision. Most of BPA is served by a Central Time System (CTS) at the Dittmer Control Center near Portland, OR. This system keeps time locally and supplies time to both the control center systems and field locations via a microwave signal. It is kept synchronized to national standard time and coordinated with interconnected utilities. It is the official BPA time. Powwer system control and operation is described, followed by a description of BPA timing systems including CTS, the Fault Location Acquisition Reporter, time dissemination, and phasor measurements. References are provided for further reading.

SPARK GAP SWITCH

DOEpatents

Neal, R.B.

1957-12-17

An improved triggered spark gap switch is described, capable of precisely controllable firing time while switching very large amounts of power. The invention in general comprises three electrodes adjustably spaced and adapted to have a large potential impressed between the outer electrodes. The central electrode includes two separate elements electrically connected togetaer and spaced apart to define a pair of spark gaps between the end electrodes. Means are provided to cause the gas flow in the switch to pass towards the central electrode, through a passage in each separate element, and out an exit disposed between the two separate central electrode elements in order to withdraw ions from the spark gap.

A Two-Phase Time Synchronization-Free Localization Algorithm for Underwater Sensor Networks.

PubMed

Luo, Junhai; Fan, Liying

2017-03-30

Underwater Sensor Networks (UWSNs) can enable a broad range of applications such as resource monitoring, disaster prevention, and navigation-assistance. Sensor nodes location in UWSNs is an especially relevant topic. Global Positioning System (GPS) information is not suitable for use in UWSNs because of the underwater propagation problems. Hence, some localization algorithms based on the precise time synchronization between sensor nodes that have been proposed for UWSNs are not feasible. In this paper, we propose a localization algorithm called Two-Phase Time Synchronization-Free Localization Algorithm (TP-TSFLA). TP-TSFLA contains two phases, namely, range-based estimation phase and range-free evaluation phase. In the first phase, we address a time synchronization-free localization scheme based on the Particle Swarm Optimization (PSO) algorithm to obtain the coordinates of the unknown sensor nodes. In the second phase, we propose a Circle-based Range-Free Localization Algorithm (CRFLA) to locate the unlocalized sensor nodes which cannot obtain the location information through the first phase. In the second phase, sensor nodes which are localized in the first phase act as the new anchor nodes to help realize localization. Hence, in this algorithm, we use a small number of mobile beacons to help obtain the location information without any other anchor nodes. Besides, to improve the precision of the range-free method, an extension of CRFLA achieved by designing a coordinate adjustment scheme is updated. The simulation results show that TP-TSFLA can achieve a relative high localization ratio without time synchronization.

A Two-Phase Time Synchronization-Free Localization Algorithm for Underwater Sensor Networks

PubMed Central

Luo, Junhai; Fan, Liying

2017-01-01

Underwater Sensor Networks (UWSNs) can enable a broad range of applications such as resource monitoring, disaster prevention, and navigation-assistance. Sensor nodes location in UWSNs is an especially relevant topic. Global Positioning System (GPS) information is not suitable for use in UWSNs because of the underwater propagation problems. Hence, some localization algorithms based on the precise time synchronization between sensor nodes that have been proposed for UWSNs are not feasible. In this paper, we propose a localization algorithm called Two-Phase Time Synchronization-Free Localization Algorithm (TP-TSFLA). TP-TSFLA contains two phases, namely, range-based estimation phase and range-free evaluation phase. In the first phase, we address a time synchronization-free localization scheme based on the Particle Swarm Optimization (PSO) algorithm to obtain the coordinates of the unknown sensor nodes. In the second phase, we propose a Circle-based Range-Free Localization Algorithm (CRFLA) to locate the unlocalized sensor nodes which cannot obtain the location information through the first phase. In the second phase, sensor nodes which are localized in the first phase act as the new anchor nodes to help realize localization. Hence, in this algorithm, we use a small number of mobile beacons to help obtain the location information without any other anchor nodes. Besides, to improve the precision of the range-free method, an extension of CRFLA achieved by designing a coordinate adjustment scheme is updated. The simulation results show that TP-TSFLA can achieve a relative high localization ratio without time synchronization. PMID:28358342

The alarming problems of confounding equivalence using logistic regression models in the perspective of causal diagrams.

PubMed

Yu, Yuanyuan; Li, Hongkai; Sun, Xiaoru; Su, Ping; Wang, Tingting; Liu, Yi; Yuan, Zhongshang; Liu, Yanxun; Xue, Fuzhong

2017-12-28

Confounders can produce spurious associations between exposure and outcome in observational studies. For majority of epidemiologists, adjusting for confounders using logistic regression model is their habitual method, though it has some problems in accuracy and precision. It is, therefore, important to highlight the problems of logistic regression and search the alternative method. Four causal diagram models were defined to summarize confounding equivalence. Both theoretical proofs and simulation studies were performed to verify whether conditioning on different confounding equivalence sets had the same bias-reducing potential and then to select the optimum adjusting strategy, in which logistic regression model and inverse probability weighting based marginal structural model (IPW-based-MSM) were compared. The "do-calculus" was used to calculate the true causal effect of exposure on outcome, then the bias and standard error were used to evaluate the performances of different strategies. Adjusting for different sets of confounding equivalence, as judged by identical Markov boundaries, produced different bias-reducing potential in the logistic regression model. For the sets satisfied G-admissibility, adjusting for the set including all the confounders reduced the equivalent bias to the one containing the parent nodes of the outcome, while the bias after adjusting for the parent nodes of exposure was not equivalent to them. In addition, all causal effect estimations through logistic regression were biased, although the estimation after adjusting for the parent nodes of exposure was nearest to the true causal effect. However, conditioning on different confounding equivalence sets had the same bias-reducing potential under IPW-based-MSM. Compared with logistic regression, the IPW-based-MSM could obtain unbiased causal effect estimation when the adjusted confounders satisfied G-admissibility and the optimal strategy was to adjust for the parent nodes of outcome, which obtained the highest precision. All adjustment strategies through logistic regression were biased for causal effect estimation, while IPW-based-MSM could always obtain unbiased estimation when the adjusted set satisfied G-admissibility. Thus, IPW-based-MSM was recommended to adjust for confounders set.

KALREF—A Kalman filter and time series approach to the International Terrestrial Reference Frame realization

NASA Astrophysics Data System (ADS)

Wu, Xiaoping; Abbondanza, Claudio; Altamimi, Zuheir; Chin, T. Mike; Collilieux, Xavier; Gross, Richard S.; Heflin, Michael B.; Jiang, Yan; Parker, Jay W.

2015-05-01

The current International Terrestrial Reference Frame is based on a piecewise linear site motion model and realized by reference epoch coordinates and velocities for a global set of stations. Although linear motions due to tectonic plates and glacial isostatic adjustment dominate geodetic signals, at today's millimeter precisions, nonlinear motions due to earthquakes, volcanic activities, ice mass losses, sea level rise, hydrological changes, and other processes become significant. Monitoring these (sometimes rapid) changes desires consistent and precise realization of the terrestrial reference frame (TRF) quasi-instantaneously. Here, we use a Kalman filter and smoother approach to combine time series from four space geodetic techniques to realize an experimental TRF through weekly time series of geocentric coordinates. In addition to secular, periodic, and stochastic components for station coordinates, the Kalman filter state variables also include daily Earth orientation parameters and transformation parameters from input data frames to the combined TRF. Local tie measurements among colocated stations are used at their known or nominal epochs of observation, with comotion constraints applied to almost all colocated stations. The filter/smoother approach unifies different geodetic time series in a single geocentric frame. Fragmented and multitechnique tracking records at colocation sites are bridged together to form longer and coherent motion time series. While the time series approach to TRF reflects the reality of a changing Earth more closely than the linear approximation model, the filter/smoother is computationally powerful and flexible to facilitate incorporation of other data types and more advanced characterization of stochastic behavior of geodetic time series.

The supplementary motor area contributes to the timing of the anticipatory postural adjustment during step initiation in participants with and without Parkinson's disease.

PubMed

Jacobs, J V; Lou, J S; Kraakevik, J A; Horak, F B

2009-12-01

The supplementary motor area (SMA) is thought to contribute to the generation of anticipatory postural adjustments (APAs, which act to stabilize supporting body segments prior to movement), but its precise role remains unclear. In addition, participants with Parkinson's disease (PD) exhibit impaired function of the SMA as well as decreased amplitudes and altered timing of the APA during step initiation, but the contribution of the SMA to these impairments also remains unclear. To determine how the SMA contributes to generating the APA and to the impaired APAs of participants with PD, we examined the voluntary steps of eight participants with PD and eight participants without PD, before and after disrupting the SMA and dorsolateral premotor cortex (dlPMC), in separate sessions, with 1-Hz repetitive transcranial magnetic stimulation (rTMS). Both groups exhibited decreased durations of their APAs after rTMS over the SMA but not over the dlPMC. Peak amplitudes of the APAs were unaffected by rTMS to either site. The symptom severity of the participants with PD positively correlated with the extent that rTMS over the SMA affected the durations of their APAs. The results suggest that the SMA contributes to the timing of the APA and that participants with PD exhibit impaired timing of their APAs, in part, due to progressive dysfunction of circuits associated with the SMA.

A Simple, Inexpensive Water-Leveling Device for Ultramicrotomy.

ERIC Educational Resources Information Center

Brooks, Austin E.

1978-01-01

Describes a device for maintaining the proper water level in knife boats during ultramicrotomy. Water levels in troughs are adjusted rapidly and precisely during the cutting process. Illustrations are included. (Author/MA)

Environmental impacts of precision feeding programs applied in pig production.

PubMed

Andretta, I; Hauschild, L; Kipper, M; Pires, P G S; Pomar, C

2017-12-04

This study was undertaken to evaluate the effect that switching from conventional to precision feeding systems during the growing-finishing phase would have on the potential environmental impact of Brazilian pig production. Standard life-cycle assessment procedures were used, with a cradle-to-farm gate boundary. The inputs and outputs of each interface of the life cycle (production of feed ingredients, processing in the feed industry, transportation and animal rearing) were organized in a model. Grain production was independently characterized in the Central-West and South regions of Brazil, whereas the pigs were raised in the South region. Three feeding programs were applied for growing-finishing pigs: conventional phase feeding by group (CON); precision daily feeding by group (PFG) (whole herd fed the same daily adjusted diet); and precision daily feeding by individual (PFI) (diets adjusted daily to match individual nutrient requirements). Raising pigs (1 t pig BW at farm gate) in South Brazil under the CON feeding program using grain cultivated in the same region led to emissions of 1840 kg of CO2-eq, 13.1 kg of PO4-eq and 32.2 kg of SO2-eq. Simulations using grain from the Central-West region showed a greater climate change impact. Compared with the previous scenario, a 17% increase in climate change impact was found when simulating with soybeans produced in Central-West Brazil, whereas a 28% increase was observed when simulating with corn and soybeans from Central-West Brazil. Compared with the CON feeding program, the PFG and PFI programs reduced the potential environmental impact. Applying the PFG program mitigated the potential climate change impact and eutrophication by up to 4%, and acidification impact by up to 3% compared with the CON program. Making a further adjustment by feeding pigs according to their individual nutrient requirements mitigated the potential climate change impact by up to 6% and the potential eutrophication and acidification impact by up to 5% compared with the CON program. The greatest environmental gains associated with the adoption of precision feeding were observed when the diet combined soybeans from Central-West Brazil with corn produced in Southern Brazil. The results clearly show that precision feeding is an effective approach for improving the environmental sustainability of Brazilian pig production.

Fixed precision sampling plans for white apple leafhopper (Homoptera: Cicadellidae) on apple.

PubMed

Beers, Elizabeth H; Jones, Vincent P

2004-10-01

Constant precision sampling plans for the white apple leafhopper, Typhlocyba pomaria McAtee, were developed so that it could be used as an indicator species for system stability as new integrated pest management programs without broad-spectrum pesticides are developed. Taylor's power law was used to model the relationship between the mean and the variance, and Green's constant precision sequential sample equation was used to develop sampling plans. Bootstrap simulations of the sampling plans showed greater precision (D = 0.25) than the desired precision (Do = 0.3), particularly at low mean population densities. We found that by adjusting the Do value in Green's equation to 0.4, we were able to reduce the average sample number by 25% and provided an average D = 0.31. The sampling plan described allows T. pomaria to be used as reasonable indicator species of agroecosystem stability in Washington apple orchards.

Stable and simple quantitative phase-contrast imaging by Fresnel biprism

NASA Astrophysics Data System (ADS)

Ebrahimi, Samira; Dashtdar, Masoomeh; Sánchez-Ortiga, Emilio; Martínez-Corral, Manuel; Javidi, Bahram

2018-03-01

Digital holographic (DH) microscopy has grown into a powerful nondestructive technique for the real-time study of living cells including dynamic membrane changes and cell fluctuations in nanometer and sub-nanometer scales. The conventional DH microscopy configurations require a separately generated coherent reference wave that results in a low phase stability and a necessity to precisely adjust the intensity ratio between two overlapping beams. In this work, we present a compact, simple, and very stable common-path DH microscope, employing a self-referencing configuration. The microscope is implemented by a diode laser as the source and a Fresnel biprism for splitting and recombining the beams simultaneously. In the overlapping area, linear interference fringes with high contrast are produced. The frequency of the interference pattern could be easily adjusted by displacement of the biprism along the optical axis without a decrease in fringe contrast. To evaluate the validity of the method, the spatial noise and temporal stability of the setup are compared with the common off-axis DH microscope based on a Mach-Zehnder interferometer. It is shown that the proposed technique has low mechanical noise as well as superb temporal stability with sub-nanometer precision without any external vibration isolation. The higher temporal stability improves the capabilities of the microscope for studying micro-object fluctuations, particularly in the case of biological specimens. Experimental results are presented using red blood cells and silica microspheres to demonstrate the system performance.

Comparing historical and modern methods of Sea Surface Temperature measurement - Part 1: Review of methods, field comparisons and dataset adjustments

NASA Astrophysics Data System (ADS)

Matthews, J. B. R.

2012-09-01

Sea Surface Temperature (SST) measurements have been obtained from a variety of different platforms, instruments and depths over the post-industrial period. Today most measurements come from ships, moored and drifting buoys and satellites. Shipboard methods include temperature measurement of seawater sampled by bucket and in engine cooling water intakes. Engine intake temperatures are generally thought to average a few tenths of a °C warmer than simultaneous bucket temperatures. Here I review SST measurement methods, studies comparing shipboard methods by field experiment and adjustments applied to SST datasets to account for variable methods. In opposition to contemporary thinking, I find average bucket-intake temperature differences reported from field studies inconclusive. Non-zero average differences often have associated standard deviations that are several times larger than the averages themselves. Further, average differences have been found to vary widely between ships and between cruises on the same ship. The cause of non-zero average differences is typically unclear given the general absence of additional temperature observations to those from buckets and engine intakes. Shipboard measurements appear of variable quality, highly dependent upon the accuracy and precision of the thermometer used and the care of the observer where manually read. Methods are generally poorly documented, with written instructions not necessarily reflecting actual practices of merchant mariners. Measurements cannot be expected to be of high quality where obtained by untrained sailors using thermometers of low accuracy and precision.

The flight test of Pi-SAR(L) for the repeat-pass interferometric SAR

NASA Astrophysics Data System (ADS)

Nohmi, Hitoshi; Shimada, Masanobu; Miyawaki, Masanori

2006-09-01

This paper describes the experiment of the repeat pass interferometric SAR using Pi-SAR(L). The air-borne repeat-pass interferometric SAR is expected as an effective method to detect landslide or predict a volcano eruption. To obtain a high-quality interferometric image, it is necessary to make two flights on the same flight pass. In addition, since the antenna of the Pi-SAR(L) is secured to the aircraft, it is necessary to fly at the same drift angle to keep the observation direction same. We built a flight control system using an auto pilot which has been installed in the airplane. This navigation system measures position and altitude precisely with using a differential GPS, and the PC Navigator outputs a difference from the desired course to the auto pilot. Since the air density is thinner and the speed is higher than the landing situation, the gain of the control system is required to be adjusted during the repeat pass flight. The observation direction could be controlled to some extent by adjusting a drift angle with using a flight speed control. The repeat-pass flight was conducted in Japan for three days in late November. The flight was stable and the deviation was within a few meters for both horizontal and vertical direction even in the gusty condition. The SAR data were processed in time domain based on range Doppler algorism to make the complete motion compensation. Thus, the interferometric image processed after precise phase compensation is shown.

In vivo thermoluminescence dosimetry for total body irradiation.

PubMed

Palkosková, P; Hlavata, H; Dvorák, P; Novotný, J; Novotný, J

2002-01-01

An improvement in the clinical results obtained using total body irradiation (TBI) with photon beams requires precise TBI treatment planning, reproducible irradiation, precise in vivo dosimetry, accurate documentation and careful evaluation. In vivo dosimetry using LiF Harshaw TLD-100 chips was used during the TBI treatments performed in our department. The results of in vivo thermoluminescence dosimetry (TLD) show that using TLD measurements and interactive adjustment of some treatment parameters based on these measurements, like monitor unit calculations, lung shielding thickness and patient positioning, it is possible to achieve high precision in absorbed dose delivery (less than 0.5%) as well as in homogeneity of irradiation (less than 6%).

Cleft Lip and Palate Repair Using a Surgical Microscope.

PubMed

Kato, Motoi; Watanabe, Azusa; Watanabe, Shoji; Utsunomiya, Hiroki; Yokoyama, Takayuki; Ogishima, Shinya

2017-11-01

Cleft lip and palate repair requires a deep and small surgical field and is usually performed by surgeons wearing surgical loupes. Surgeons with loupes can obtain a wider surgical view, although headlights are required for the deepest procedures. Surgical microscopes offer comfort and a clear and magnification-adjustable surgical site that can be shared with the whole team, including observers, and easily recorded to further the education of junior surgeons. Magnification adjustments are convenient for precise procedures such as muscle dissection of the soft palate. We performed a comparative investigation of 18 cleft operations that utilized either surgical loupes or microscopy. Paper-based questionnaires were completed by staff nurses to evaluate what went well and what could be improved in each procedure. The operating time, complication rate, and scores of the questionnaire responses were statistically analyzed. The operating time when microscopy was used was not significantly longer than when surgical loupes were utilized. The surgical field was clearly shared with surgical assistants, nurses, anesthesiologists, and students via microscope-linked monitors. Passing surgical equipment was easier when sharing the surgical view, and preoperative microscope preparation did not interfere with the duties of the staff nurses. Surgical microscopy was demonstrated to be useful during cleft operations.

Study on high-precision measurement of long radius of curvature

NASA Astrophysics Data System (ADS)

Wu, Dongcheng; Peng, Shijun; Gao, Songtao

2016-09-01

It is hard to get high-precision measurement of the radius of curvature (ROC), because of many factors that affect the measurement accuracy. For the measurement of long radius of curvature, some factors take more important position than others'. So, at first this paper makes some research about which factor is related to the long measurement distance, and also analyse the uncertain of the measurement accuracy. At second this article also study the influence about the support status and the adjust error about the cat's eye and confocal position. At last, a 1055micrometer radius of curvature convex is measured in high-precision laboratory. Experimental results show that the proper steady support (three-point support) can guarantee the high-precision measurement of radius of curvature. Through calibrating the gain of cat's eye and confocal position, is useful to ensure the precise position in order to increase the measurement accuracy. After finish all the above process, the high-precision long ROC measurement is realized.

A FORTRAN realization of the block adjustment of CCD frames

NASA Astrophysics Data System (ADS)

Yu, Yong; Tang, Zhenghong; Li, Jinling; Zhao, Ming

A FORTRAN version realization of the block adjustment (BA) of overlapping CCD frames is developed. The flowchart is introduced including (a) data collection, (b) preprocessing, and (c) BA and object positioning. The subroutines and their functions are also demonstrated. The program package is tested by simulated data with/without the application of white noises. It is also preliminarily applied to the reduction of optical positions of four extragalactic radio sources. The results show that because of the increase in the sky coverage and number of reference stars, the precision of deducted positions is improved compared with single plate adjustment.

Testing the limits of temporal stability: Willingness to pay values among Grand Canyon whitewater boaters across decades

USGS Publications Warehouse

Neher, Chris J.; Duffield, John; Bair, Lucas S.; Patterson, David A.; Neher, Katherine

2017-01-01

We directly compare trip willingness to pay (WTP) values between 1985 and 2015 stated preference surveys of private party Grand Canyon boaters using identically designed valuation methods. The temporal gap of 30 years between these two studies is well beyond that of any tests of WTP temporal stability in the literature. Comparisons were made of mean WTP estimates for four hypothetical Colorado River flow level scenarios. WTP values from the 1985 survey were adjusted to 2015 levels using the consumer price index. Mean WTP precision was estimated through simulation. No statistically significant differences were detected between the adjusted Bishop et al. (1987) and the current study mean WTP estimates. Examination of pooled models of the data from the studies suggest that while the estimated WTP values are stable over time, the underlying valuation functions may not be, particularly when the data and models are corrected to account for differing bid structures and possible panel effects.

Testing the Limits of Temporal Stability: Willingness to Pay Values among Grand Canyon Whitewater Boaters Across Decades

NASA Astrophysics Data System (ADS)

Neher, Chris; Duffield, John; Bair, Lucas; Patterson, David; Neher, Katherine

2017-12-01

We directly compare trip willingness to pay (WTP) values between 1985 and 2015 stated preference surveys of private party Grand Canyon boaters using identically designed valuation methods. The temporal gap of 30 years between these two studies is well beyond that of any tests of WTP temporal stability in the literature. Comparisons were made of mean WTP estimates for four hypothetical Colorado River flow level scenarios. WTP values from the 1985 survey were adjusted to 2015 levels using the consumer price index. Mean WTP precision was estimated through simulation. No statistically significant differences were detected between the adjusted Bishop et al. (1987) and the current study mean WTP estimates. Examination of pooled models of the data from the studies suggest that while the estimated WTP values are stable over time, the underlying valuation functions may not be, particularly when the data and models are corrected to account for differing bid structures and possible panel effects.

Forecasting of foreign exchange rates of Taiwan’s major trading partners by novel nonlinear Grey Bernoulli model NGBM(1, 1)

NASA Astrophysics Data System (ADS)

Chen, Chun-I.; Chen, Hong Long; Chen, Shuo-Pei

2008-08-01

The traditional Grey Model is easy to understand and simple to calculate, with satisfactory accuracy, but it is also lack of flexibility to adjust the model to acquire higher forecasting precision. This research studies feasibility and effectiveness of a novel Grey model together with the concept of the Bernoulli differential equation in ordinary differential equation. In this research, the author names this newly proposed model as Nonlinear Grey Bernoulli Model (NGBM). The NGBM is nonlinear differential equation with power index n. By controlling n, the curvature of the solution curve could be adjusted to fit the result of one time accumulated generating operation (1-AGO) of raw data. One extreme case from Grey system textbook is studied by NGBM, and two published articles are chosen for practical tests of NGBM. The results prove the novel NGBM is feasible and efficient. Finally, NGBM is used to forecast 2005 foreign exchange rates of twelve Taiwan major trading partners, including Taiwan.

Design and implementation of a compliant robot with force feedback and strategy planning software

NASA Technical Reports Server (NTRS)

Premack, T.; Strempek, F. M.; Solis, L. A.; Brodd, S. S.; Cutler, E. P.; Purves, L. R.

1984-01-01

Force-feedback robotics techniques are being developed for automated precision assembly and servicing of NASA space flight equipment. Design and implementation of a prototype robot which provides compliance and monitors forces is in progress. Computer software to specify assembly steps and makes force feedback adjustments during assembly are coded and tested for three generically different precision mating problems. A model program demonstrates that a suitably autonomous robot can plan its own strategy.

KSC-03PD-3269

NASA Technical Reports Server (NTRS)

2003-01-01

VANDENBERG AFB, CALIF. A worker in the NASA spacecraft processing facility on North Vandenberg Air Force Base adjust the supports on a solar array panel to be lifted and installed on the Gravity Probe B spacecraft. Installing each array is a 3-day process and includes a functional deployment test. The Gravity Probe B mission is a relativity experiment developed by NASAs Marshall Space Flight Center, Stanford University and Lockheed Martin. The spacecraft will test two extraordinary predictions of Albert Einsteins general theory of relativity that he advanced in 1916: the geodetic effect (how space and time are warped by the presence of the Earth) and frame dragging (how Earths rotation drags space and time around with it). Gravity Probe B consists of four sophisticated gyroscopes that will provide an almost perfect space-time reference system. The mission will look in a precision manner for tiny changes in the direction of spin.

A Novel Zero Velocity Interval Detection Algorithm for Self-Contained Pedestrian Navigation System with Inertial Sensors

PubMed Central

Tian, Xiaochun; Chen, Jiabin; Han, Yongqiang; Shang, Jianyu; Li, Nan

2016-01-01

Zero velocity update (ZUPT) plays an important role in pedestrian navigation algorithms with the premise that the zero velocity interval (ZVI) should be detected accurately and effectively. A novel adaptive ZVI detection algorithm based on a smoothed pseudo Wigner–Ville distribution to remove multiple frequencies intelligently (SPWVD-RMFI) is proposed in this paper. The novel algorithm adopts the SPWVD-RMFI method to extract the pedestrian gait frequency and to calculate the optimal ZVI detection threshold in real time by establishing the function relationships between the thresholds and the gait frequency; then, the adaptive adjustment of thresholds with gait frequency is realized and improves the ZVI detection precision. To put it into practice, a ZVI detection experiment is carried out; the result shows that compared with the traditional fixed threshold ZVI detection method, the adaptive ZVI detection algorithm can effectively reduce the false and missed detection rate of ZVI; this indicates that the novel algorithm has high detection precision and good robustness. Furthermore, pedestrian trajectory positioning experiments at different walking speeds are carried out to evaluate the influence of the novel algorithm on positioning precision. The results show that the ZVI detected by the adaptive ZVI detection algorithm for pedestrian trajectory calculation can achieve better performance. PMID:27669266

Ductile cutting of silicon microstructures with surface inclination measurement and compensation by using a force sensor integrated single point diamond tool

NASA Astrophysics Data System (ADS)

Chen, Yuan-Liu; Cai, Yindi; Shimizu, Yuki; Ito, So; Gao, Wei; Ju, Bing-Feng

2016-02-01

This paper presents a measurement and compensation method of surface inclination for ductile cutting of silicon microstructures by using a diamond tool with a force sensor based on a four-axis ultra-precision lathe. The X- and Y-directional inclinations of a single crystal silicon workpiece with respect to the X- and Y-motion axes of the lathe slides were measured respectively by employing the diamond tool as a touch-trigger probe, in which the tool-workpiece contact is sensitively detected by monitoring the force sensor output. Based on the measurement results, fabrication of silicon microstructures can be thus carried out directly along the tilted silicon workpiece by compensating the cutting motion axis to be parallel to the silicon surface without time-consuming pre-adjustment of the surface inclination or turning of a flat surface. A diamond tool with a negative rake angle was used in the experiment for superior ductile cutting performance. The measurement precision by using the diamond tool as a touch-trigger probe was investigated. Experiments of surface inclination measurement and ultra-precision ductile cutting of a micro-pillar array and a micro-pyramid array with inclination compensation were carried out respectively to demonstrate the feasibility of the proposed method.

Development and Validation of RP-HPLC Method for the Estimation of Ivabradine Hydrochloride in Tablets

PubMed Central

Seerapu, Sunitha; Srinivasan, B. P.

2010-01-01

A simple, sensitive, precise and robust reverse–phase high-performance liquid chromatographic method for analysis of ivabradine hydrochloride in pharmaceutical formulations was developed and validated as per ICH guidelines. The separation was performed on SS Wakosil C18AR, 250×4.6 mm, 5 μm column with methanol:25 mM phosphate buffer (60:40 v/v), adjusted to pH 6.5 with orthophosphoric acid, added drop wise, as mobile phase. A well defined chromatographic peak of Ivabradine hydrochloride was exhibited with a retention time of 6.55±0.05 min and tailing factor of 1.14 at the flow rate of 0.8 ml/min and at ambient temperature, when monitored at 285 nm. The linear regression analysis data for calibration plots showed good linear relationship with R=0.9998 in the concentration range of 30-210 μg/ml. The method was validated for precision, recovery and robustness. Intra and Inter-day precision (% relative standard deviation) were always less than 2%. The method showed the mean % recovery of 99.00 and 98.55 % for Ivabrad and Inapure tablets, respectively. The proposed method has been successfully applied to the commercial tablets without any interference of excipients. PMID:21695008

Personalized or Precision Medicine? The Example of Cystic Fibrosis

PubMed Central

Marson, Fernando A. L.; Bertuzzo, Carmen S.; Ribeiro, José D.

2017-01-01

The advent of the knowledge on human genetics, by the identification of disease-associated variants, culminated in the understanding of human variability. With the genetic knowledge, the specificity of the clinical phenotype and the drug response of each individual were understood. Using the cystic fibrosis (CF) as an example, the new terms that emerged such as personalized medicine and precision medicine can be characterized. The genetic knowledge in CF is broad and the presence of a monogenic disease caused by mutations in the CFTR gene enables the phenotype–genotype association studies (including the response to drugs), considering the wide clinical and laboratory spectrum dependent on the mutual action of genotype, environment, and lifestyle. Regarding the CF disease, personalized medicine is the treatment directed at the symptoms, and this treatment is adjusted depending on the patient’s phenotype. However, more recently, the term precision medicine began to be widely used, although its correct application and understanding are still vague and poorly characterized. In precision medicine, we understand the individual as a response to the interrelation between environment, lifestyle, and genetic factors, which enabled the advent of new therapeutic models, such as conventional drugs adjustment by individual patient dosage and drug type and response, development of new drugs (read through, broker, enhancer, stabilizer, and amplifier compounds), genome editing by homologous recombination, zinc finger nucleases, TALEN (transcription activator-like effector nuclease), CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats-CRISPR-associated endonuclease 9), and gene therapy. Thus, we introduced the terms personalized medicine and precision medicine based on the CF. PMID:28676762

Precision adjustable stage

DOEpatents

Cutburth, Ronald W.; Silva, Leonard L.

1988-01-01

An improved mounting stage of the type used for the detection of laser beams is disclosed. A stage center block is mounted on each of two opposite sides by a pair of spaced ball bearing tracks which provide stability as well as simplicity. The use of the spaced ball bearing pairs in conjunction with an adjustment screw which also provides support eliminates extraneous stabilization components and permits maximization of the area of the center block laser transmission hole.

Arabidopsis plants perform arithmetic division to prevent starvation at night

PubMed Central

Scialdone, Antonio; Mugford, Sam T; Feike, Doreen; Skeffington, Alastair; Borrill, Philippa; Graf, Alexander; Smith, Alison M; Howard, Martin

2013-01-01

Photosynthetic starch reserves that accumulate in Arabidopsis leaves during the day decrease approximately linearly with time at night to support metabolism and growth. We find that the rate of decrease is adjusted to accommodate variation in the time of onset of darkness and starch content, such that reserves last almost precisely until dawn. Generation of these dynamics therefore requires an arithmetic division computation between the starch content and expected time to dawn. We introduce two novel chemical kinetic models capable of implementing analog arithmetic division. Predictions from the models are successfully tested in plants perturbed by a night-time light period or by mutations in starch degradation pathways. Our experiments indicate which components of the starch degradation apparatus may be important for appropriate arithmetic division. Our results are potentially relevant for any biological system dependent on a food reserve for survival over a predictable time period. DOI: http://dx.doi.org/10.7554/eLife.00669.001 PMID:23805380

Trans-oral miniature X-ray radiation delivery system with endoscopic optical feedback.

PubMed

Boese, Axel; Johnson, Fredrick; Ebert, Till; Mahmoud-Pashazadeh, Ali; Arens, Christoph; Friebe, Michael

2017-11-01

Surgery, chemo- and/or external radiation therapy are the standard therapy options for the treatment of laryngeal cancer. Trans-oral access for the surgery reduces traumata and hospitalization time. A new trend in treatment is organ-preserving surgery. To avoid regrowth of cancer, this type of surgery can be combined with radiation therapy. Since external radiation includes healthy tissue surrounding the cancerous zone, a local and direct intraoral radiation delivery would be beneficial. A general concept for a trans-oral radiation system was designed, based on clinical need identification with a medical user. A miniaturized X-ray tube was used as the radiation source for the intraoperative radiation delivery. To reduce dose distribution on healthy areas, the X-ray source was collimated by a newly designed adjustable shielding system as part of the housing. For direct optical visualization of the radiation zone, a miniature flexible endoscope was integrated into the system. The endoscopic light cone and the field of view were aligned with the zone of the collimated radiation. The intraoperative radiation system was mounted on a semi-automatic medical holder that was combined with a frontal actuator for rotational and translational movement using piezoelectric motors to provide precise placement. The entire technical set-up was tested in a simulated environment. The shielding of the X-ray source was verified by performing conventional detector-based dose measurements. The delivered dose was estimated by an ionization chamber. The adjustment of the radiation zone was performed by a manual controlling mechanism integrated into the hand piece of the device. An endoscopic fibre was also added to offer visualization and illumination of the radiation zone. The combination of the radiation system with the semi-automatic holder and actuator offered precise and stable positioning of the device in range of micrometres and will allow for future combination with a radiation planning system. The presented system was designed for radiation therapy of the oral cavity and the larynx. This first set-up tried to cover all clinical aspects that are necessary for a later use in surgery. The miniaturized X-ray tube offers the size and the power for intraoperative radiation therapy. The adjustable shielding system in combination with the holder and actuator provides a precise placement. The visualization of radiation zone allows a targeting and observation of the radiation zone.

Efficient Training of Supervised Spiking Neural Network via Accurate Synaptic-Efficiency Adjustment Method.

PubMed

Xie, Xiurui; Qu, Hong; Yi, Zhang; Kurths, Jurgen

2017-06-01

The spiking neural network (SNN) is the third generation of neural networks and performs remarkably well in cognitive tasks, such as pattern recognition. The temporal neural encode mechanism found in biological hippocampus enables SNN to possess more powerful computation capability than networks with other encoding schemes. However, this temporal encoding approach requires neurons to process information serially on time, which reduces learning efficiency significantly. To keep the powerful computation capability of the temporal encoding mechanism and to overcome its low efficiency in the training of SNNs, a new training algorithm, the accurate synaptic-efficiency adjustment method is proposed in this paper. Inspired by the selective attention mechanism of the primate visual system, our algorithm selects only the target spike time as attention areas, and ignores voltage states of the untarget ones, resulting in a significant reduction of training time. Besides, our algorithm employs a cost function based on the voltage difference between the potential of the output neuron and the firing threshold of the SNN, instead of the traditional precise firing time distance. A normalized spike-timing-dependent-plasticity learning window is applied to assigning this error to different synapses for instructing their training. Comprehensive simulations are conducted to investigate the learning properties of our algorithm, with input neurons emitting both single spike and multiple spikes. Simulation results indicate that our algorithm possesses higher learning performance than the existing other methods and achieves the state-of-the-art efficiency in the training of SNN.

Design and analysis of a 3D Elliptical Micro-Displacement Motion Stage

NASA Astrophysics Data System (ADS)

Lin, Jieqiong; Zhao, Dongpo; Lu, Mingming; Zhou, Jiakang

2017-12-01

Micro-displacement motion stage driven by piezoelectric actuator has a significant demand in the field of ultra-precision machining in recent years, while the design of micro-displacement motion stage plays an important role to realize a large displacement output and high precision control. Thus, a 3D elliptical micro-displacement motion stage driven by three PZT actuators has been developed. Firstly, the 3D elliptical trajectory of this motion stage could be adjusted through the form of the PZT actuators input signal. Then, the desired trajectory was obtained by adjusting the micro displacement of the motion stage in 3D elliptical space. Finally, the trajectory simulation and the finite element simulation were applied in this motion stage. The experimental results shown that, the output displacement of the three directions under the input force of the 1600N were 14μm, 16μm and 74μm, respectively. And the first three modes were 1471.6Hz, 2698.4Hz and 2803.4Hz, respectively. Analysis and experiments were carried out to verify the performance, result proved that a large output displacement and high precision control could be obtained.

Overcoming the detection bandwidth limit in precision spectroscopy: The analytical apparatus function for a stepped frequency scan

NASA Astrophysics Data System (ADS)

Rohart, François

2017-01-01

In a previous paper [Rohart et al., Phys Rev A 2014;90(042506)], the influence of detection-bandwidth properties on observed line-shapes in precision spectroscopy was theoretically modeled for the first time using the basic model of a continuous sweeping of the laser frequency. Specific experiments confirmed general theoretical trends but also revealed several insufficiencies of the model in case of stepped frequency scans. As a consequence in as much as up-to-date experiments use step-by-step frequency-swept lasers, a new model of the influence of the detection-bandwidth is developed, including a realistic timing of signal sampling and frequency changes. Using Fourier transform techniques, the resulting time domain apparatus function gets a simple analytical form that can be easily implemented in line-shape fitting codes without any significant increase of computation durations. This new model is then considered in details for detection systems characterized by 1st and 2nd order bandwidths, underlining the importance of the ratio of detection time constant to frequency step duration, namely for the measurement of line frequencies. It also allows a straightforward analysis of corresponding systematic deviations on retrieved line frequencies and broadenings. Finally, a special attention is paid to consequences of a finite detection-bandwidth in Doppler Broadening Thermometry, namely to experimental adjustments required for a spectroscopic determination of the Boltzmann constant at the 1-ppm level of accuracy. In this respect, the interest of implementing a Butterworth 2nd order filter is emphasized.

Fabrication of precision optics using an imbedded reference surface

DOEpatents

Folta, James A.; Spiller, Eberhard

2005-02-01

The figure of a substrate is very precisely measured and a figured-correcting layer is provided on the substrate. The thickness of the figure-correcting layer is locally measured and compared to the first measurement. The local measurement of the figure-correcting layer is accomplished through a variety of methods, including interferometry and fluorescence or ultrasound measurements. Adjustments in the thickness of the figure-correcting layer are made until the top of the figure-correcting layer matches a desired figure specification.

Etude des performances de solveurs deterministes sur un coeur rapide a caloporteur sodium

NASA Astrophysics Data System (ADS)

Bay, Charlotte

The reactors of next generation, in particular SFR model, represent a true challenge for current codes and solvers, used mainly for thermic cores. There is no guarantee that their competences could be straight adapted to fast neutron spectrum, or to major design differences. Thus it is necessary to assess the validity of solvers and their potential shortfall in the case of fast neutron reactors. As part of an internship with CEA (France), and at the instigation of EPM Nuclear Institute, this study concerns the following codes : DRAGON/DONJON, ERANOS, PARIS and APOLLO3. The precision assessment has been performed using Monte Carlo code TRIPOLI4. Only core calculation was of interest, namely numerical methods competences in precision and rapidity. Lattice code was not part of the study, that is to say nuclear data, self-shielding, or isotopic compositions. Nor was tackled burnup or time evolution effects. The study consists in two main steps : first evaluating the sensitivity of each solver to calculation parameters, and obtain its optimal calculation set ; then compare their competences in terms of precision and rapidity, by collecting usual quantities (effective multiplication factor, reaction rates map), but also more specific quantities which are crucial to the SFR design, namely control rod worth and sodium void effect. The calculation time is also a key factor. Whatever conclusion or recommendation that could be drawn from this study, they must first of all be applied within similar frameworks, that is to say small fast neutron cores with hexagonal geometry. Eventual adjustments for big cores will have to be demonstrated in developments of this study.

Spot-Welding Gun With Adjustable Pneumatic Spring

NASA Technical Reports Server (NTRS)

Burley, Richard K.

1990-01-01

Proposed spot-welding gun equipped with pneumatic spring, which could be bellows or piston and cylinder, exerts force independent of position along stroke. Applies accurate controlled force to joint welded, without precise positioning at critical position within stroke.

Soil Macronutrient Sensing for Precision Agriculture

USDA-ARS?s Scientific Manuscript database

Accurate measurements of soil macronutrients (i.e., nitrogen, phosphorus, and potassium) are needed for efficient agricultural production, including site-specific crop management (SSCM), where fertilizer nutrient application rates are adjusted spatially based on local requirements. Rapid, non-destru...

Semi-Global Matching with Self-Adjusting Penalties

NASA Astrophysics Data System (ADS)

Karkalou, E.; Stentoumis, C.; Karras, G.

2017-02-01

The demand for 3D models of various scales and precisions is strong for a wide range of applications, among which cultural heritage recording is particularly important and challenging. In this context, dense image matching is a fundamental task for processes which involve image-based reconstruction of 3D models. Despite the existence of commercial software, the need for complete and accurate results under different conditions, as well as for computational efficiency under a variety of hardware, has kept image-matching algorithms as one of the most active research topics. Semi-global matching (SGM) is among the most popular optimization algorithms due to its accuracy, computational efficiency, and simplicity. A challenging aspect in SGM implementation is the determination of smoothness constraints, i.e. penalties P1, P2 for disparity changes and discontinuities. In fact, penalty adjustment is needed for every particular stereo-pair and cost computation. In this work, a novel formulation of self-adjusting penalties is proposed: SGM penalties can be estimated solely from the statistical properties of the initial disparity space image. The proposed method of self-adjusting penalties (SGM-SAP) is evaluated using typical cost functions on stereo-pairs from the recent Middlebury dataset of interior scenes, as well as from the EPFL Herz-Jesu architectural scenes. Results are competitive against the original SGM estimates. The significant aspects of self-adjusting penalties are: (i) the time-consuming tuning process is avoided; (ii) SGM can be used in image collections with limited number of stereo-pairs; and (iii) no heuristic user intervention is needed.

Measurement of high-pressure shock waves in cryogenic deuterium-tritium ice layered capsule implosions on NIF.

PubMed

Robey, H F; Moody, J D; Celliers, P M; Ross, J S; Ralph, J; Le Pape, S; Berzak Hopkins, L; Parham, T; Sater, J; Mapoles, E R; Holunga, D M; Walters, C F; Haid, B J; Kozioziemski, B J; Dylla-Spears, R J; Krauter, K G; Frieders, G; Ross, G; Bowers, M W; Strozzi, D J; Yoxall, B E; Hamza, A V; Dzenitis, B; Bhandarkar, S D; Young, B; Van Wonterghem, B M; Atherton, L J; Landen, O L; Edwards, M J; Boehly, T R

2013-08-09

The first measurements of multiple, high-pressure shock waves in cryogenic deuterium-tritium (DT) ice layered capsule implosions on the National Ignition Facility have been performed. The strength and relative timing of these shocks must be adjusted to very high precision in order to keep the DT fuel entropy low and compressibility high. All previous measurements of shock timing in inertial confinement fusion implosions [T. R. Boehly et al., Phys. Rev. Lett. 106, 195005 (2011), H. F. Robey et al., Phys. Rev. Lett. 108, 215004 (2012)] have been performed in surrogate targets, where the solid DT ice shell and central DT gas regions were replaced with a continuous liquid deuterium (D2) fill. This report presents the first experimental validation of the assumptions underlying this surrogate technique.

High-precision method of binocular camera calibration with a distortion model.

PubMed

Li, Weimin; Shan, Siyu; Liu, Hui

2017-03-10

A high-precision camera calibration method for binocular stereo vision system based on a multi-view template and alternative bundle adjustment is presented in this paper. The proposed method could be achieved by taking several photos on a specially designed calibration template that has diverse encoded points in different orientations. In this paper, the method utilized the existing algorithm used for monocular camera calibration to obtain the initialization, which involves a camera model, including radial lens distortion and tangential distortion. We created a reference coordinate system based on the left camera coordinate to optimize the intrinsic parameters of left camera through alternative bundle adjustment to obtain optimal values. Then, optimal intrinsic parameters of the right camera can be obtained through alternative bundle adjustment when we create a reference coordinate system based on the right camera coordinate. We also used all intrinsic parameters that were acquired to optimize extrinsic parameters. Thus, the optimal lens distortion parameters and intrinsic and extrinsic parameters were obtained. Synthetic and real data were used to test the method. The simulation results demonstrate that the maximum mean absolute relative calibration errors are about 3.5e-6 and 1.2e-6 for the focal length and the principal point, respectively, under zero-mean Gaussian noise with 0.05 pixels standard deviation. The real result shows that the reprojection error of our model is about 0.045 pixels with the relative standard deviation of 1.0e-6 over the intrinsic parameters. The proposed method is convenient, cost-efficient, highly precise, and simple to carry out.

Nanometer-scale displacement measurement with high resolution using dual cavity Fabry-Pérot interferometer for biomimetic robots.

PubMed

Lee, Jin-Hyuk; Kim, Dae-Hyun

2014-10-01

A sensor of a biomimetic robot has to measure very small environmental changes such as, nanometer scale strains or displacements. Fiber optic sensor can be also one of candidates for the biomimetic sensor because the sensor is like thread and the shape of the sensor is similar to muscle fiber. A fiber optic interferometer, which is an optical-based sensor, can measure displacement precisely, so such device has been widely studied for the measurement of displacement on a nanometer-scale. Especially, a Quadrature Phase-Shifted Fiber Fabry-Pérot interferometer (QPS-FFPI) uses phase-information for this measurement, allowing it to provide a precision result with high resolution. In theory, the QPS-FFPI generates two sinusoidal signals of which the phase difference should be 90 degrees for the exact measurement of the displacement. In order to guarantee the condition of the phase difference, the relative adjustment of the cavities of the optical fibers is required. However, with such precise adjustment it is very hard to fix the proper difference of the two cavities for quadrature-phase-shifting. In this paper, a dual-cavity FFPI is newly proposed to measure the displacement on a nanometer-scale with a specific type of signal processing. In the signal processing, a novel phase-compensation algorithm is applied to force the phase difference to be exactly 90 degrees without any physical adjustment. As a result, the paper shows that the phase-compensated dual-cavity FFPI can effectively measure nanometer-scale displacement with high resolution under dynamic conditions.

The computer-aided parallel external fixator for complex lower limb deformity correction.

PubMed

Wei, Mengting; Chen, Jianwen; Guo, Yue; Sun, Hao

2017-12-01

Since parameters of the parallel external fixator are difficult to measure and calculate in real applications, this study developed computer software that can help the doctor measure parameters using digital technology and generate an electronic prescription for deformity correction. According to Paley's deformity measurement method, we provided digital measurement techniques. In addition, we proposed an deformity correction algorithm to calculate the elongations of the six struts and developed a electronic prescription software. At the same time, a three-dimensional simulation of the parallel external fixator and deformed fragment was made using virtual reality modeling language technology. From 2013 to 2015, fifteen patients with complex lower limb deformity were treated with parallel external fixators and the self-developed computer software. All of the cases had unilateral limb deformity. The deformities were caused by old osteomyelitis in nine cases and traumatic sequelae in six cases. A doctor measured the related angulation, displacement and rotation on postoperative radiographs using the digital measurement techniques. Measurement data were input into the electronic prescription software to calculate the daily adjustment elongations of the struts. Daily strut adjustments were conducted according to the data calculated. The frame was removed when expected results were achieved. Patients lived independently during the adjustment. The mean follow-up was 15 months (range 10-22 months). The duration of frame fixation from the time of application to the time of removal averaged 8.4 months (range 2.5-13.1 months). All patients were satisfied with the corrected limb alignment. No cases of wound infections or complications occurred. Using the computer-aided parallel external fixator for the correction of lower limb deformities can achieve satisfactory outcomes. The correction process can be simplified and is precise and digitized, which will greatly improve the treatment in a clinical application.

Burnishing Systems: a Short Survey of the State-of-the-art

NASA Astrophysics Data System (ADS)

Bobrovskij, I. N.

2018-01-01

The modern technological solutions allowing to implement a new technology of surface plastic deformation are considered. The technological device allowing to implement the technology of hyper productive surface plastic deformation or wide burnishing (machining time is up to 2-3 revolutions of workpiece) is presented. The device provides the constant force of instruments regardless the beating, non-roundness and other surface shape defects; usable and easily controlled force adjustment; precise installation of instruments and holders toward the along the worpieces axis; automation of the supply and retraction of instruments. Also the device allowing to implement the technology of nanostructuring burnishing is presented. The design of the device allows to eliminate the effect of auto-oscillations.

Impacting device for testing insulation

NASA Technical Reports Server (NTRS)

Redmon, J. W. (Inventor)

1984-01-01

An electro-mechanical impacting device for testing the bonding of foam insulation to metal is descirbed. The device lightly impacts foam insulation attached to metal to determine whether the insulation is properly bonded to the metal and to determine the quality of the bond. A force measuring device, preferably a load cell mounted on the impacting device, measures the force of the impact and the duration of the time the hammer head is actually in contact with the insulation. The impactor is designed in the form of a handgun having a driving spring which can propel a plunger forward to cause a hammer head to impact the insulation. The device utilizes a trigger mechanism which provides precise adjustements, allowing fireproof operation.

Validation of geometric models for fisheye lenses

NASA Astrophysics Data System (ADS)

Schneider, D.; Schwalbe, E.; Maas, H.-G.

The paper focuses on the photogrammetric investigation of geometric models for different types of optical fisheye constructions (equidistant, equisolid-angle, sterographic and orthographic projection). These models were implemented and thoroughly tested in a spatial resection and a self-calibrating bundle adjustment. For this purpose, fisheye images were taken with a Nikkor 8 mm fisheye lens on a Kodak DSC 14n Pro digital camera in a hemispherical calibration room. Both, the spatial resection and the bundle adjustment resulted in a standard deviation of unit weight of 1/10 pixel with a suitable set of simultaneous calibration parameters introduced into the camera model. The camera-lens combination was treated with all of the four basic models mentioned above. Using the same set of additional lens distortion parameters, the differences between the models can largely be compensated, delivering almost the same precision parameters. The relative object space precision obtained from the bundle adjustment was ca. 1:10 000 of the object dimensions. This value can be considered as a very satisfying result, as fisheye images generally have a lower geometric resolution as a consequence of their large field of view and also have a inferior imaging quality in comparison to most central perspective lenses.

Bundle Block Adjustment of Airborne Three-Line Array Imagery Based on Rotation Angles

PubMed Central

Zhang, Yongjun; Zheng, Maoteng; Huang, Xu; Xiong, Jinxin

2014-01-01

In the midst of the rapid developments in electronic instruments and remote sensing technologies, airborne three-line array sensors and their applications are being widely promoted and plentiful research related to data processing and high precision geo-referencing technologies is under way. The exterior orientation parameters (EOPs), which are measured by the integrated positioning and orientation system (POS) of airborne three-line sensors, however, have inevitable systematic errors, so the level of precision of direct geo-referencing is not sufficiently accurate for surveying and mapping applications. Consequently, a few ground control points are necessary to refine the exterior orientation parameters, and this paper will discuss bundle block adjustment models based on the systematic error compensation and the orientation image, considering the principle of an image sensor and the characteristics of the integrated POS. Unlike the models available in the literature, which mainly use a quaternion to represent the rotation matrix of exterior orientation, three rotation angles are directly used in order to effectively model and eliminate the systematic errors of the POS observations. Very good experimental results have been achieved with several real datasets that verify the correctness and effectiveness of the proposed adjustment models. PMID:24811075

Bundle block adjustment of airborne three-line array imagery based on rotation angles.

PubMed

Zhang, Yongjun; Zheng, Maoteng; Huang, Xu; Xiong, Jinxin

2014-05-07

In the midst of the rapid developments in electronic instruments and remote sensing technologies, airborne three-line array sensors and their applications are being widely promoted and plentiful research related to data processing and high precision geo-referencing technologies is under way. The exterior orientation parameters (EOPs), which are measured by the integrated positioning and orientation system (POS) of airborne three-line sensors, however, have inevitable systematic errors, so the level of precision of direct geo-referencing is not sufficiently accurate for surveying and mapping applications. Consequently, a few ground control points are necessary to refine the exterior orientation parameters, and this paper will discuss bundle block adjustment models based on the systematic error compensation and the orientation image, considering the principle of an image sensor and the characteristics of the integrated POS. Unlike the models available in the literature, which mainly use a quaternion to represent the rotation matrix of exterior orientation, three rotation angles are directly used in order to effectively model and eliminate the systematic errors of the POS observations. Very good experimental results have been achieved with several real datasets that verify the correctness and effectiveness of the proposed adjustment models.

78 FR 57129 - Notice of Petitions by Firms for Determination of Eligibility To Apply for Trade Adjustment...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-17

... component parts for the construction, industrial, agricultural and automotive markets. Sakco Precision, Inc... Street, 9/11/2013 The firm manufactures Mount Pleasant, PA components comprised of 15666. densified wood...

UV254 absorbance as real-time monitoring and control parameter for micropollutant removal in advanced wastewater treatment with powdered activated carbon.

PubMed

Altmann, Johannes; Massa, Lukas; Sperlich, Alexander; Gnirss, Regina; Jekel, Martin

2016-05-01

This study investigates the applicability of UV absorbance measurements at 254 nm (UVA254) to serve as a simple and reliable surrogate parameter to monitor and control the removal of organic micropollutants (OMPs) in advanced wastewater treatment applying powdered activated carbon (PAC). Correlations between OMP removal and corresponding UVA254 reduction were determined in lab-scale adsorption batch tests and successfully applied to a pilot-scale PAC treatment stage to predict OMP removals in aggregate samples with good accuracy. Real-time UVA254 measurements were utilized to evaluate adapted PAC dosing strategies and proved to be effective for online monitoring of OMP removal. Furthermore, active PAC dosing control according to differential UVA254 measurements was implemented and tested. While precise removal predictions based on real-time measurements were not accurate for all OMPs, UVA254-controlled dynamic PAC dosing was capable of achieving stable OMP removals. UVA254 can serve as an effective surrogate parameter for OMP removal in technical PAC applications. Even though the applicability as control parameter to adjust PAC dosing to water quality changes might be limited to applications with fast response between PAC adjustment and adsorptive removal (e.g. direct filtration), UVA254 measurements can also be used to monitor the adsorption efficiency in more complex PAC applications. Copyright © 2016 Elsevier Ltd. All rights reserved.

Functional sensibility assessment. Part II: Effects of sensory improvement on precise pinch force modulation after transverse carpal tunnel release.

PubMed

Hsu, Hsiu-Yun; Kuo, Li-Chieh; Chiu, Haw-Yen; Jou, I-Ming; Su, Fong-Chin

2009-11-01

Patients with median nerve compression at the carpal tunnel often have poor sensory afferents. Without adequate sensory modulation control, these patients frequently exhibit clumsy performance and excessive force output in the affected hand. We analyzed precision grip function after the sensory recovery of patients with carpal tunnel syndrome (CTS) who underwent carpal tunnel release (CTR). Thirteen CTS patients were evaluated using a custom-designed pinch device and conventional sensory tools before and after CTR to measure sensibility, maximum pinch strength, and anticipated pinch force adjustments to movement-induced load fluctuations in a pinch-holding-up activity. Based on these tests, five force-related parameters and sensory measurements were used to determine improvements in pinch performance after sensory recovery. The force ratio between the exerted pinch force and maximum load force of the lifting object was used to determine pinch force coordination and to prove that CTR enabled precision motor output. The magnitude of peak pinch force indicated an economic force output during manipulations following CTR. The peak pinch force, force ratio, and percentage of maximum pinch force also demonstrated a moderate correlation with the Semmes-Weinstein test. Analysis of these tests revealed that improved sensory function helped restore patients' performance in precise pinch force control evaluations. These results suggest that sensory information plays an important role in adjusting balanced force output in dexterous manipulation. (c) 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

Moving objects with clumsy fingers: how predictive is grip force control in patients with impaired manual sensibility?

PubMed

Nowak, Dennis A; Hermsdörfer, Joachim; Marquardt, Christian; Topka, Helge

2003-03-01

Anticipatory grip force adjustments to movement-induced load fluctuations of a hand-held object suggest that motion planning is based on an internal forward model of both the external object properties and the dynamics of the own motor apparatus. However, the central nervous system also refers to real time sensory feedback from the grasping digits in order to achieve a highly economical coupling between grip force and the actual loading requirements. We analyzed grip force control during vertical point-to-point arm movements with a hand-held instrumented object in 9 patients with moderately impaired tactile sensibility of the grasping digits due to chronic median nerve compression (n = 3), axonal (n = 3) and demyelinating sensory polyneuropathy (n = 3) in comparison to 9 healthy age- and sex-matched control subjects. Point-to-point arm movements started and ended with the object being held stationary at rest. Load force changes arose from inertial loads related to the movement. A maximum of load force occurred early in upward and near the end of downward movements. Compared to healthy controls, patients with impaired manual sensibility generated similar static grip forces during stationary holding of the object and similar force ratios between maximum grip and load force. These findings reflect effective grip force scaling in relation to the movement-induced loads despite reduced afferent feedback from the grasping digits. For both groups the maxima of grip and load force coincided very closely in time, indicating that the temporal regulation of the grip force profile with the load profile was processed with a similar high precision. In addition, linear regression analyses between grip and load forces during movement-related load increase and load decrease phases revealed a similar precise temporo-spatial coupling between grip and load forces for patients and controls. Our results suggest that the precise and anticipatory adjustment of the grip force profile to the load force profile arising from voluntary arm movements with a hand-held object is centrally mediated and less under sensory feedback control. As suggested by previous investigations, the efficient scaling of the grip force magnitude in relation to the movement-induced loads may be intact when deficits of tactile sensibility from the grasping fingers are moderate.

Pricise Target Geolocation and Tracking Based on Uav Video Imagery

NASA Astrophysics Data System (ADS)

Hosseinpoor, H. R.; Samadzadegan, F.; Dadrasjavan, F.

2016-06-01

There is an increasingly large number of applications for Unmanned Aerial Vehicles (UAVs) from monitoring, mapping and target geolocation. However, most of commercial UAVs are equipped with low-cost navigation sensors such as C/A code GPS and a low-cost IMU on board, allowing a positioning accuracy of 5 to 10 meters. This low accuracy cannot be used in applications that require high precision data on cm-level. This paper presents a precise process for geolocation of ground targets based on thermal video imagery acquired by small UAV equipped with RTK GPS. The geolocation data is filtered using an extended Kalman filter, which provides a smoothed estimate of target location and target velocity. The accurate geo-locating of targets during image acquisition is conducted via traditional photogrammetric bundle adjustment equations using accurate exterior parameters achieved by on board IMU and RTK GPS sensors, Kalman filtering and interior orientation parameters of thermal camera from pre-flight laboratory calibration process. The results of this study compared with code-based ordinary GPS, indicate that RTK observation with proposed method shows more than 10 times improvement of accuracy in target geolocation.

Web-based visualization of very large scientific astronomy imagery

NASA Astrophysics Data System (ADS)

Bertin, E.; Pillay, R.; Marmo, C.

2015-04-01

Visualizing and navigating through large astronomy images from a remote location with current astronomy display tools can be a frustrating experience in terms of speed and ergonomics, especially on mobile devices. In this paper, we present a high performance, versatile and robust client-server system for remote visualization and analysis of extremely large scientific images. Applications of this work include survey image quality control, interactive data query and exploration, citizen science, as well as public outreach. The proposed software is entirely open source and is designed to be generic and applicable to a variety of datasets. It provides access to floating point data at terabyte scales, with the ability to precisely adjust image settings in real-time. The proposed clients are light-weight, platform-independent web applications built on standard HTML5 web technologies and compatible with both touch and mouse-based devices. We put the system to the test and assess the performance of the system and show that a single server can comfortably handle more than a hundred simultaneous users accessing full precision 32 bit astronomy data.

Tank 241-B-108, cores 172 and 173 analytical results for the final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nuzum, J.L., Fluoro Daniel Hanford

1997-03-04

The Data Summary Table (Table 3) included in this report compiles analytical results in compliance with all applicable DQOS. Liquid subsamples that were prepared for analysis by an acid adjustment of the direct subsample are indicated by a `D` in the A column in Table 3. Solid subsamples that were prepared for analysis by performing a fusion digest are indicated by an `F` in the A column in Table 3. Solid subsamples that were prepared for analysis by performing a water digest are indicated by a I.wl. or an `I` in the A column of Table 3. Due to poormore » precision and accuracy in original analysis of both Lower Half Segment 2 of Core 173 and the core composite of Core 173, fusion and water digests were performed for a second time. Precision and accuracy improved with the repreparation of Core 173 Composite. Analyses with the repreparation of Lower Half Segment 2 of Core 173 did not show improvement and suggest sample heterogeneity. Results from both preparations are included in Table 3.« less

Waveguide Harmonic Generator for the SIM

NASA Technical Reports Server (NTRS)

Chang, Daniel; Poberezhskiy, Ilya; Mulder, Jerry

2008-01-01

A second-harmonic generator (SHG) serves as the source of the visible laser beam in an onboard calibration scheme for NASA's planned Space Interferometry Mission (SIM), which requires an infrared laser beam and a visible laser beam coherent with the infrared laser beam. The SHG includes quasi-phase-matched waveguides made of MgO-doped, periodically poled lithium niobate, pigtailed with polarization- maintaining optical fibers. Frequency doubling by use of such waveguides affords the required combination of coherence and sufficient conversion efficiency for the intended application. The spatial period of the poling is designed to obtain quasi-phase- matching at a nominal middle excitation wavelength of 1,319.28 nm. The SHG is designed to operate at a warm bias (ambient temperature between 20 and 25 C) that would be maintained in its cooler environment by use of electric heaters; the heater power would be adjusted to regulate the temperature precisely and thereby maintain the required precision of the spatial period. At the state of development at the time of this reporting, the SHG had been packaged and subjected to most of its planned space-qualification tests.

Femtosecond profiling of shaped x-ray pulses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoffmann, M. C.; Grguras, I.; Behrens, C.

Arbitrary manipulation of the temporal and spectral properties of x-ray pulses at free-electron lasers would revolutionize many experimental applications. At the Linac Coherent Light Source at Stanford National Accelerator Laboratory, the momentum phase-space of the free-electron laser driving electron bunch can be tuned to emit a pair of x-ray pulses with independently variable photon energy and femtosecond delay. However, while accelerator parameters can easily be adjusted to tune the electron bunch phase-space, the final impact of these actuators on the x-ray pulse cannot be predicted with sufficient precision. Furthermore, shot-to-shot instabilities that distort the pulse shape unpredictably cannot be fullymore » suppressed. Therefore, the ability to directly characterize the x-rays is essential to ensure precise and consistent control. In this work, we have generated x-ray pulse pairs via electron bunch shaping and characterized them on a single-shot basis with femtosecond resolution through time-resolved photoelectron streaking spectroscopy. Furthermore, this achievement completes an important step toward future x-ray pulse shaping techniques.« less

Femtosecond profiling of shaped x-ray pulses

DOE PAGES

Hoffmann, M. C.; Grguras, I.; Behrens, C.; ...

2018-03-26

Arbitrary manipulation of the temporal and spectral properties of x-ray pulses at free-electron lasers would revolutionize many experimental applications. At the Linac Coherent Light Source at Stanford National Accelerator Laboratory, the momentum phase-space of the free-electron laser driving electron bunch can be tuned to emit a pair of x-ray pulses with independently variable photon energy and femtosecond delay. However, while accelerator parameters can easily be adjusted to tune the electron bunch phase-space, the final impact of these actuators on the x-ray pulse cannot be predicted with sufficient precision. Furthermore, shot-to-shot instabilities that distort the pulse shape unpredictably cannot be fullymore » suppressed. Therefore, the ability to directly characterize the x-rays is essential to ensure precise and consistent control. In this work, we have generated x-ray pulse pairs via electron bunch shaping and characterized them on a single-shot basis with femtosecond resolution through time-resolved photoelectron streaking spectroscopy. Furthermore, this achievement completes an important step toward future x-ray pulse shaping techniques.« less

Cataract Surgery From 1918 to the Present and Future-Just Imagine!

PubMed

Olson, Randall J

2018-01-01

To review the history of cataract surgery over the past 100 years, and to offer predictions about new developments that may occur during the next 50 years. Interpretive essay. Review of historical literature and author experiences pertaining to cataract surgery, with commentary and perspective. By this time, cataract surgery has advanced to the point that Kelman's introduction of phacoemulsification and use of intraocular lenses (IOLs), both very controversial when initially introduced, have become state of the art. Outpatient surgery, minimally limited mobility, sutureless incisions, and topical anesthesia also have become key components of standard treatment. The author envisions availability of medications for nuclear sclerosis and presbyopia, expansion of lens surgery for refractive purposes with postsurgical adjustment and unprecedented precision, increased mechanization of lens removal with emphasis on uncomplicated surgery rather than refractive precision, and accommodating IOLs all becoming standard. Acknowledging and appreciating the past contributions of pioneers in cataract surgery is vital to understanding the development of today's clinical care. Clues as to the future do help give us a possible scenario worthy of such conjecture. Copyright © 2017 Elsevier Inc. All rights reserved.

Negative emotion enhances mnemonic precision and subjective feelings of remembering in visual long-term memory.

PubMed

Xie, Weizhen; Zhang, Weiwei

2017-09-01

Negative emotion sometimes enhances memory (higher accuracy and/or vividness, e.g., flashbulb memories). The present study investigates whether it is the qualitative (precision) or quantitative (the probability of successful retrieval) aspect of memory that drives these effects. In a visual long-term memory task, observers memorized colors (Experiment 1a) or orientations (Experiment 1b) of sequentially presented everyday objects under negative, neutral, or positive emotions induced with International Affective Picture System images. In a subsequent test phase, observers reconstructed objects' colors or orientations using the method of adjustment. We found that mnemonic precision was enhanced under the negative condition relative to the neutral and positive conditions. In contrast, the probability of successful retrieval was comparable across the emotion conditions. Furthermore, the boost in memory precision was associated with elevated subjective feelings of remembering (vividness and confidence) and metacognitive sensitivity in Experiment 2. Altogether, these findings suggest a novel precision-based account for emotional memories. Copyright © 2017 Elsevier B.V. All rights reserved.

Improved Conjugate Gradient Bundle Adjustment of Dunhuang Wall Painting Images

NASA Astrophysics Data System (ADS)

Hu, K.; Huang, X.; You, H.

2017-09-01

Bundle adjustment with additional parameters is identified as a critical step for precise orthoimage generation and 3D reconstruction of Dunhuang wall paintings. Due to the introduction of self-calibration parameters and quasi-planar constraints, the structure of coefficient matrix of the reduced normal equation is banded-bordered, making the solving process of bundle adjustment complex. In this paper, Conjugate Gradient Bundle Adjustment (CGBA) method is deduced by calculus of variations. A preconditioning method based on improved incomplete Cholesky factorization is adopt to reduce the condition number of coefficient matrix, as well as to accelerate the iteration rate of CGBA. Both theoretical analysis and experimental results comparison with conventional method indicate that, the proposed method can effectively conquer the ill-conditioned problem of normal equation and improve the calculation efficiency of bundle adjustment with additional parameters considerably, while maintaining the actual accuracy.

The impact of early visual cortex transcranial magnetic stimulation on visual working memory precision and guess rate.

PubMed

Rademaker, Rosanne L; van de Ven, Vincent G; Tong, Frank; Sack, Alexander T

2017-01-01

Neuroimaging studies have demonstrated that activity patterns in early visual areas predict stimulus properties actively maintained in visual working memory. Yet, the mechanisms by which such information is represented remain largely unknown. In this study, observers remembered the orientations of 4 briefly presented gratings, one in each quadrant of the visual field. A 10Hz Transcranial Magnetic Stimulation (TMS) triplet was applied directly at stimulus offset, or midway through a 2-second delay, targeting early visual cortex corresponding retinotopically to a sample item in the lower hemifield. Memory for one of the four gratings was probed at random, and participants reported this orientation via method of adjustment. Recall errors were smaller when the visual field location targeted by TMS overlapped with that of the cued memory item, compared to errors for stimuli probed diagonally to TMS. This implied topographic storage of orientation information, and a memory-enhancing effect at the targeted location. Furthermore, early pulses impaired performance at all four locations, compared to late pulses. Next, response errors were fit empirically using a mixture model to characterize memory precision and guess rates. Memory was more precise for items proximal to the pulse location, irrespective of pulse timing. Guesses were more probable with early TMS pulses, regardless of stimulus location. Thus, while TMS administered at the offset of the stimulus array might disrupt early-phase consolidation in a non-topographic manner, TMS also boosts the precise representation of an item at its targeted retinotopic location, possibly by increasing attentional resources or by injecting a beneficial amount of noise.

The impact of early visual cortex transcranial magnetic stimulation on visual working memory precision and guess rate

PubMed Central

van de Ven, Vincent G.; Tong, Frank; Sack, Alexander T.

2017-01-01

Neuroimaging studies have demonstrated that activity patterns in early visual areas predict stimulus properties actively maintained in visual working memory. Yet, the mechanisms by which such information is represented remain largely unknown. In this study, observers remembered the orientations of 4 briefly presented gratings, one in each quadrant of the visual field. A 10Hz Transcranial Magnetic Stimulation (TMS) triplet was applied directly at stimulus offset, or midway through a 2-second delay, targeting early visual cortex corresponding retinotopically to a sample item in the lower hemifield. Memory for one of the four gratings was probed at random, and participants reported this orientation via method of adjustment. Recall errors were smaller when the visual field location targeted by TMS overlapped with that of the cued memory item, compared to errors for stimuli probed diagonally to TMS. This implied topographic storage of orientation information, and a memory-enhancing effect at the targeted location. Furthermore, early pulses impaired performance at all four locations, compared to late pulses. Next, response errors were fit empirically using a mixture model to characterize memory precision and guess rates. Memory was more precise for items proximal to the pulse location, irrespective of pulse timing. Guesses were more probable with early TMS pulses, regardless of stimulus location. Thus, while TMS administered at the offset of the stimulus array might disrupt early-phase consolidation in a non-topographic manner, TMS also boosts the precise representation of an item at its targeted retinotopic location, possibly by increasing attentional resources or by injecting a beneficial amount of noise. PMID:28384347

A validated ultra high-pressure liquid chromatography method for separation of candesartan cilexetil impurities and its degradents in drug product

PubMed Central

Kumar, Namala Durga Atchuta; Babu, K. Sudhakar; Gosada, Ullas; Sharma, Nitish

2012-01-01

Introduction: A selective, specific, and sensitive “Ultra High-Pressure Liquid Chromatography” (UPLC) method was developed for determination of candesartan cilexetil impurities as well asits degradent in tablet formulation. Materials and Methods: The chromatographic separation was performed on Waters Acquity UPLC system and BEH Shield RP18 column using gradient elution of mobile phase A and B. 0.01 M phosphate buffer adjusted pH 3.0 with Orthophosphoric acid was used as mobile phase A and 95% acetonitrile with 5% Milli Q Water was used as mobile phase B. Ultraviolet (UV) detection was performed at 254 nm and 210 nm, where (CDS-6), (CDS-5), (CDS-7), (Ethyl Candesartan), (Desethyl CCX), (N-Ethyl), (CCX-1), (1 N Ethyl Oxo CCX), (2 N Ethyl Oxo CCX), (2 N Ethyl) and any unknown impurity were monitored at 254 nm wavelength, and two process-related impurities, trityl alcohol and MTE impurity, were estimated at 210 nm. Candesartan cilexetil andimpurities were chromatographed with a total run time of 20 min. Results: Calibration showed that the response of impurity was a linear function of concentration over the range limit of quantification to 2 μg/mL (r2≥0.999) and the method was validated over this range for precision, intermediate precision, accuracy, linearity, and specificity. For the precision study, percentage relative standard deviation of each impurity was <15% (n=6). Conclusion: The method was found to be precise, accurate, linear, and specific. The proposed method was successfully employed for estimation of candesartan cilexetil impurities in pharmaceutical preparations. PMID:23781475

The 400 microsphere per piece "rule" does not apply to all blood flow studies.

PubMed

Polissar, N L; Stanford, D C; Glenny, R W

2000-01-01

Microsphere experiments are useful in measuring regional organ perfusion as well as heterogeneity of blood flow within organs and correlation of perfusion between organ pieces at different time points. A 400 microspheres/piece "rule" is often used in planning experiments or to determine whether experiments are valid. This rule is based on the statement that 400 microspheres must lodge in a region for 95% confidence that the observed flow in the region is within 10% of the true flow. The 400 microspheres precision rule, however, only applies to measurements of perfusion to a single region or organ piece. Examples, simulations, and an animal experiment were carried out to show that good precision for measurements of heterogeneity and correlation can be obtained from many experiments with <400 microspheres/piece. Furthermore, methods were developed and tested for correcting the observed heterogeneity and correlation to remove the Poisson "noise" due to discrete microsphere measurements. The animal experiment shows adjusted values of heterogeneity and correlation that are in close agreement for measurements made with many or few microspheres/piece. Simulations demonstrate that the adjusted values are accurate for a variety of experiments with far fewer than 400 microspheres/piece. Thus the 400 microspheres rule does not apply to many experiments. A "rule of thumb" is that experiments with a total of at least 15,000 microspheres, for all pieces combined, are very likely to yield accurate estimates of heterogeneity. Experiments with a total of at least 25,000 microspheres are very likely to yield accurate estimates of correlation coefficients.

Base line estimation using single passes of laser data

NASA Technical Reports Server (NTRS)

Dunn, P. J.; Torrence, M.; Smith, D. E.; Kolenkiewicz, R.

1979-01-01

The laser data of the GEOS 3 satellite passes observed by four stations at Greenbelt (Maryland), Bermuda, Grand Turk Island (Bahamas) and Patrick Air Force Base (Florida), were employed to determine precise interstation base lines and relative heights in short orbital arcs of no more than 12-min duration. No more than five arcs of data are required to define the interstation base lines to 30-cm precision. Base lines running parallel to the orbital motion can be defined to submeter precision from a single short arc of data. Combining arcs of different orbital geometry in a common adjustment of two or more stations relative to the base station helps to compensate for weak base line definition in any single arc. This technique can be used for tracking such spacecraft as Lageos, a high-altitude retroreflector-carrying satellite designed for precise laser ranging studies.

Precision optical slit for high heat load or ultra high vacuum

DOEpatents

Andresen, N.C.; DiGennaro, R.S.; Swain, T.L.

1995-01-24

This invention relates generally to slits used in optics that must be precisely aligned and adjusted. The optical slits of the present invention are useful in x-ray optics, x-ray beam lines, optical systems in which the entrance slit is critical for high wavelength resolution. The invention is particularly useful in ultra high vacuum systems where lubricants are difficult to use and designs which avoid the movement of metal parts against one another are important, such as monochromators for high wavelength resolution with ultra high vacuum systems. The invention further relates to optical systems in which temperature characteristics of the slit materials is important. The present invention yet additionally relates to precision slits wherein the opposing edges of the slit must be precisely moved relative to a center line between the edges with each edge retaining its parallel orientation with respect to the other edge and/or the center line. 21 figures.

Precision optical slit for high heat load or ultra high vacuum

DOEpatents

Andresen, Nord C.; DiGennaro, Richard S.; Swain, Thomas L.

1995-01-01

This invention relates generally to slits used in optics that must be precisely aligned and adjusted. The optical slits of the present invention are useful in x-ray optics, x-ray beam lines, optical systems in which the entrance slit is critical for high wavelength resolution. The invention is particularly useful in ultra high vacuum systems where lubricants are difficult to use and designs which avoid the movement of metal parts against one another are important, such as monochrometers for high wavelength resolution with ultra high vacuum systems. The invention further relates to optical systems in which temperature characteristics of the slit materials is important. The present invention yet additionally relates to precision slits wherein the opposing edges of the slit must be precisely moved relative to a center line between the edges with each edge retaining its parallel orientation with respect to the other edge and/or the center line.

Memory color of natural familiar objects: effects of surface texture and 3-D shape.

PubMed

Vurro, Milena; Ling, Yazhu; Hurlbert, Anya C

2013-06-28

Natural objects typically possess characteristic contours, chromatic surface textures, and three-dimensional shapes. These diagnostic features aid object recognition, as does memory color, the color most associated in memory with a particular object. Here we aim to determine whether polychromatic surface texture, 3-D shape, and contour diagnosticity improve memory color for familiar objects, separately and in combination. We use solid three-dimensional familiar objects rendered with their natural texture, which participants adjust in real time to match their memory color for the object. We analyze mean, accuracy, and precision of the memory color settings relative to the natural color of the objects under the same conditions. We find that in all conditions, memory colors deviate slightly but significantly in the same direction from the natural color. Surface polychromaticity, shape diagnosticity, and three dimensionality each improve memory color accuracy, relative to uniformly colored, generic, or two-dimensional shapes, respectively. Shape diagnosticity improves the precision of memory color also, and there is a trend for polychromaticity to do so as well. Differently from other studies, we find that the object contour alone also improves memory color. Thus, enhancing the naturalness of the stimulus, in terms of either surface or shape properties, enhances the accuracy and precision of memory color. The results support the hypothesis that memory color representations are polychromatic and are synergistically linked with diagnostic shape representations.

Accounting for time- and space-varying changes in the gravity field to improve the network adjustment of relative-gravity data

USGS Publications Warehouse

Kennedy, Jeffrey R.; Ferre, Ty P.A.

2015-01-01

The relative gravimeter is the primary terrestrial instrument for measuring spatially and temporally varying gravitational fields. The background noise of the instrument—that is, non-linear drift and random tares—typically requires some form of least-squares network adjustment to integrate data collected during a campaign that may take several days to weeks. Here, we present an approach to remove the change in the observed relative-gravity differences caused by hydrologic or other transient processes during a single campaign, so that the adjusted gravity values can be referenced to a single epoch. The conceptual approach is an example of coupled hydrogeophysical inversion, by which a hydrologic model is used to inform and constrain the geophysical forward model. The hydrologic model simulates the spatial variation of the rate of change of gravity as either a linear function of distance from an infiltration source, or using a 3-D numerical groundwater model. The linear function can be included in and solved for as part of the network adjustment. Alternatively, the groundwater model is used to predict the change of gravity at each station through time, from which the accumulated gravity change is calculated and removed from the data prior to the network adjustment. Data from a field experiment conducted at an artificial-recharge facility are used to verify our approach. Maximum gravity change due to hydrology (observed using a superconducting gravimeter) during the relative-gravity field campaigns was up to 2.6 μGal d−1, each campaign was between 4 and 6 d and one month elapsed between campaigns. The maximum absolute difference in the estimated gravity change between two campaigns, two months apart, using the standard network adjustment method and the new approach, was 5.5 μGal. The maximum gravity change between the same two campaigns was 148 μGal, and spatial variation in gravity change revealed zones of preferential infiltration and areas of relatively high groundwater storage. The accommodation for spatially varying gravity change would be most important for long-duration campaigns, campaigns with very rapid changes in gravity and (or) campaigns where especially precise observed relative-gravity differences are used in the network adjustment.

An approach for filtering hyperbolically positioned underwater acoustic telemetry data with position precision estimates

USGS Publications Warehouse

Meckley, Trevor D.; Holbrook, Christopher M.; Wagner, C. Michael; Binder, Thomas R.

2014-01-01

The use of position precision estimates that reflect the confidence in the positioning process should be considered prior to the use of biological filters that rely on a priori expectations of the subject’s movement capacities and tendencies. Position confidence goals should be determined based upon the needs of the research questions and analysis requirements versus arbitrary selection, in which filters of previous studies are adopted. Data filtering with this approach ensures that data quality is sufficient for the selected analyses and presents the opportunity to adjust or identify a different analysis in the event that the requisite precision was not attained. Ignoring these steps puts a practitioner at risk of reporting errant findings.

Network Design in Close-Range Photogrammetry with Short Baseline Images

NASA Astrophysics Data System (ADS)

Barazzetti, L.

2017-08-01

The avaibility of automated software for image-based 3D modelling has changed the way people acquire images for photogrammetric applications. Short baseline images are required to match image points with SIFT-like algorithms, obtaining more images than those necessary for "old fashioned" photogrammetric projects based on manual measurements. This paper describes some considerations on network design for short baseline image sequences, especially on precision and reliability of bundle adjustment. Simulated results reveal that the large number of 3D points used for image orientation has very limited impact on network precision.

Ensemble-based methods for forecasting census in hospital units

PubMed Central

2013-01-01

Background The ability to accurately forecast census counts in hospital departments has considerable implications for hospital resource allocation. In recent years several different methods have been proposed forecasting census counts, however many of these approaches do not use available patient-specific information. Methods In this paper we present an ensemble-based methodology for forecasting the census under a framework that simultaneously incorporates both (i) arrival trends over time and (ii) patient-specific baseline and time-varying information. The proposed model for predicting census has three components, namely: current census count, number of daily arrivals and number of daily departures. To model the number of daily arrivals, we use a seasonality adjusted Poisson Autoregressive (PAR) model where the parameter estimates are obtained via conditional maximum likelihood. The number of daily departures is predicted by modeling the probability of departure from the census using logistic regression models that are adjusted for the amount of time spent in the census and incorporate both patient-specific baseline and time varying patient-specific covariate information. We illustrate our approach using neonatal intensive care unit (NICU) data collected at Women & Infants Hospital, Providence RI, which consists of 1001 consecutive NICU admissions between April 1st 2008 and March 31st 2009. Results Our results demonstrate statistically significant improved prediction accuracy for 3, 5, and 7 day census forecasts and increased precision of our forecasting model compared to a forecasting approach that ignores patient-specific information. Conclusions Forecasting models that utilize patient-specific baseline and time-varying information make the most of data typically available and have the capacity to substantially improve census forecasts. PMID:23721123

Ensemble-based methods for forecasting census in hospital units.

PubMed

Koestler, Devin C; Ombao, Hernando; Bender, Jesse

2013-05-30

The ability to accurately forecast census counts in hospital departments has considerable implications for hospital resource allocation. In recent years several different methods have been proposed forecasting census counts, however many of these approaches do not use available patient-specific information. In this paper we present an ensemble-based methodology for forecasting the census under a framework that simultaneously incorporates both (i) arrival trends over time and (ii) patient-specific baseline and time-varying information. The proposed model for predicting census has three components, namely: current census count, number of daily arrivals and number of daily departures. To model the number of daily arrivals, we use a seasonality adjusted Poisson Autoregressive (PAR) model where the parameter estimates are obtained via conditional maximum likelihood. The number of daily departures is predicted by modeling the probability of departure from the census using logistic regression models that are adjusted for the amount of time spent in the census and incorporate both patient-specific baseline and time varying patient-specific covariate information. We illustrate our approach using neonatal intensive care unit (NICU) data collected at Women & Infants Hospital, Providence RI, which consists of 1001 consecutive NICU admissions between April 1st 2008 and March 31st 2009. Our results demonstrate statistically significant improved prediction accuracy for 3, 5, and 7 day census forecasts and increased precision of our forecasting model compared to a forecasting approach that ignores patient-specific information. Forecasting models that utilize patient-specific baseline and time-varying information make the most of data typically available and have the capacity to substantially improve census forecasts.

EDTA analysis on the Roche MODULAR analyser.

PubMed

Davidson, D F

2007-05-01

Patient specimens can be subject to subtle interference from cross contamination by liquid-based, potassium-containing EDTA anticoagulant, leading to misinterpretation of results. A rapid method for EDTA analysis to detect such contamination is described. An in-house EDTA assay on the Roche MODULAR analyser was assessed for accuracy and precision by comparison with an adjusted calcium difference measurement (atomic absorption and o-cresolphthalein complexone colorimetry). EDTA method versus adjusted calcium difference showed: slope = 1.038 (95% confidence interval [CI] 0.949-1.131); intercept = 0.073 (95% CI 0.018-0.132) mmol/L; r = 0.914; n = 94. However, inter-assay precision of the calcium difference method was estimated to be poorer (coefficient of variation 24.8% versus 3.4% for the automated colorimetric method at an EDTA concentration of 0.25 mmol/L). Unequivocal contamination was observed at an EDTA concentration of > or =0.2 mmol/L. The automated method showed positive interference from haemolysis and negative interference from oxalate. The method was unaffected by lipaemia (triglycerides <20 mmol/L), icterus (bilirubin <500 micromol/L), glucose (<100 mmol/L), iron (<100 micromol/L), and citrate, phosphate or fluoride (all <2.5 mmol/L). The automated colorimetric assay described is an accurate, precise and rapid (3 min) means of detecting EDTA contamination of unhaemolysed biochemistry specimens.

Adjustable mounting device for high-volume production of beam-shaping systems for high-power diode lasers

NASA Astrophysics Data System (ADS)

Haag, Sebastian; Bernhardt, Henning; Rübenach, Olaf; Haverkamp, Tobias; Müller, Tobias; Zontar, Daniel; Brecher, Christian

2015-02-01

In many applications for high-power diode lasers, the production of beam-shaping and homogenizing optical systems experience rising volumes and dynamical market demands. The automation of assembly processes on flexible and reconfigurable machines can contribute to a more responsive and scalable production. The paper presents a flexible mounting device designed for the challenging assembly of side-tab based optical systems. It provides design elements for precisely referencing and fixating two optical elements in a well-defined geometric relation. Side tabs are presented to the machine allowing the application of glue and a rotating mechanism allows the attachment to the optical elements. The device can be adjusted to fit different form factors and it can be used in high-volume assembly machines. The paper shows the utilization of the device for a collimation module consisting of a fast-axis and a slow-axis collimation lens. Results regarding the repeatability and process capability of bonding side tab assemblies as well as estimates from 3D simulation for overall performance indicators achieved such as cycle time and throughput will be discussed.

[Motion control of moving mirror based on fixed-mirror adjustment in FTIR spectrometer].

PubMed

Li, Zhong-bing; Xu, Xian-ze; Le, Yi; Xu, Feng-qiu; Li, Jun-wei

2012-08-01

The performance of the uniform motion of the moving mirror, which is the only constant motion part in FTIR spectrometer, and the performance of the alignment of the fixed mirror play a key role in FTIR spectrometer, and affect the interference effect and the quality of the spectrogram and may restrict the precision and resolution of the instrument directly. The present article focuses on the research on the uniform motion of the moving mirror and the alignment of the fixed mirror. In order to improve the FTIR spectrometer, the maglev support system was designed for the moving mirror and the phase detection technology was adopted to adjust the tilt angle between the moving mirror and the fixed mirror. This paper also introduces an improved fuzzy PID control algorithm to get the accurate speed of the moving mirror and realize the control strategy from both hardware design and algorithm. The results show that the development of the moving mirror motion control system gets sufficient accuracy and real-time, which can ensure the uniform motion of the moving mirror and the alignment of the fixed mirror.

Applying Dispersive Changes to Lagrangian Particles in Groundwater Transport Models

USGS Publications Warehouse

Konikow, Leonard F.

2010-01-01

Method-of-characteristics groundwater transport models require that changes in concentrations computed within an Eulerian framework to account for dispersion be transferred to moving particles used to simulate advective transport. A new algorithm was developed to accomplish this transfer between nodal values and advecting particles more precisely and realistically compared to currently used methods. The new method scales the changes and adjustments of particle concentrations relative to limiting bounds of concentration values determined from the population of adjacent nodal values. The method precludes unrealistic undershoot or overshoot for concentrations of individual particles. In the new method, if dispersion causes cell concentrations to decrease during a time step, those particles in the cell having the highest concentration will decrease the most, and those with the lowest concentration will decrease the least. The converse is true if dispersion is causing concentrations to increase. Furthermore, if the initial concentration on a particle is outside the range of the adjacent nodal values, it will automatically be adjusted in the direction of the acceptable range of values. The new method is inherently mass conservative. ?? US Government 2010.

Applying dispersive changes to Lagrangian particles in groundwater transport models

USGS Publications Warehouse

Konikow, Leonard F.

2010-01-01

Method-of-characteristics groundwater transport models require that changes in concentrations computed within an Eulerian framework to account for dispersion be transferred to moving particles used to simulate advective transport. A new algorithm was developed to accomplish this transfer between nodal values and advecting particles more precisely and realistically compared to currently used methods. The new method scales the changes and adjustments of particle concentrations relative to limiting bounds of concentration values determined from the population of adjacent nodal values. The method precludes unrealistic undershoot or overshoot for concentrations of individual particles. In the new method, if dispersion causes cell concentrations to decrease during a time step, those particles in the cell having the highest concentration will decrease the most, and those with the lowest concentration will decrease the least. The converse is true if dispersion is causing concentrations to increase. Furthermore, if the initial concentration on a particle is outside the range of the adjacent nodal values, it will automatically be adjusted in the direction of the acceptable range of values. The new method is inherently mass conservative.

Reliability of system for precise cold forging

NASA Astrophysics Data System (ADS)

Krušič, Vid; Rodič, Tomaž

2017-07-01

The influence of scatter of principal input parameters of the forging system on the dimensional accuracy of product and on the tool life for closed-die forging process is presented in this paper. Scatter of the essential input parameters for the closed-die upsetting process was adjusted to the maximal values that enabled the reliable production of a dimensionally accurate product at optimal tool life. An operating window was created in which exists the maximal scatter of principal input parameters for the closed-die upsetting process that still ensures the desired dimensional accuracy of the product and the optimal tool life. Application of the adjustment of the process input parameters is shown on the example of making an inner race of homokinetic joint from mass production. High productivity in manufacture of elements by cold massive extrusion is often achieved by multiple forming operations that are performed simultaneously on the same press. By redesigning the time sequences of forming operations at multistage forming process of starter barrel during the working stroke the course of the resultant force is optimized.

Kriging modeling and SPSA adjusting PID with KPWF compensator control of IPMC gripper for mm-sized objects

NASA Astrophysics Data System (ADS)

Chen, Yang; Hao, Lina; Yang, Hui; Gao, Jinhai

2017-12-01

Ionic polymer metal composite (IPMC) as a new smart material has been widely concerned in the micromanipulation field. In this paper, a novel two-finger gripper which contains an IPMC actuator and an ultrasensitive force sensor is proposed and fabricated. The IPMC as one finger of the gripper for mm-sized objects can achieve gripping and releasing motion, and the other finger works not only as a support finger but also as a force sensor. Because of the feedback signal of the force sensor, this integrated actuating and sensing gripper can complete gripping miniature objects in millimeter scale. The Kriging model is used to describe nonlinear characteristics of the IPMC for the first time, and then the control scheme called simultaneous perturbation stochastic approximation adjusting a proportion integration differentiation parameter controller with a Kriging predictor wavelet filter compensator is applied to track the gripping force of the gripper. The high precision force tracking in the foam ball manipulation process is obtained on a semi-physical experimental platform, which demonstrates that this gripper for mm-sized objects can work well in manipulation applications.

A Neural Network Underlying Circadian Entrainment and Photoperiodic Adjustment of Sleep and Activity in Drosophila.

PubMed

Schlichting, Matthias; Menegazzi, Pamela; Lelito, Katharine R; Yao, Zepeng; Buhl, Edgar; Dalla Benetta, Elena; Bahle, Andrew; Denike, Jennifer; Hodge, James John; Helfrich-Förster, Charlotte; Shafer, Orie Thomas

2016-08-31

A sensitivity of the circadian clock to light/dark cycles ensures that biological rhythms maintain optimal phase relationships with the external day. In animals, the circadian clock neuron network (CCNN) driving sleep/activity rhythms receives light input from multiple photoreceptors, but how these photoreceptors modulate CCNN components is not well understood. Here we show that the Hofbauer-Buchner eyelets differentially modulate two classes of ventral lateral neurons (LNvs) within the Drosophila CCNN. The eyelets antagonize Cryptochrome (CRY)- and compound-eye-based photoreception in the large LNvs while synergizing CRY-mediated photoreception in the small LNvs. Furthermore, we show that the large LNvs interact with subsets of "evening cells" to adjust the timing of the evening peak of activity in a day length-dependent manner. Our work identifies a peptidergic connection between the large LNvs and a group of evening cells that is critical for the seasonal adjustment of circadian rhythms. In animals, circadian clocks have evolved to orchestrate the timing of behavior and metabolism. Consistent timing requires the entrainment these clocks to the solar day, a process that is critical for an organism's health. Light cycles are the most important external cue for the entrainment of circadian clocks, and the circadian system uses multiple photoreceptors to link timekeeping to the light/dark cycle. How light information from these photorecptors is integrated into the circadian clock neuron network to support entrainment is not understood. Our results establish that input from the HB eyelets differentially impacts the physiology of neuronal subgroups. This input pathway, together with input from the compound eyes, precisely times the activity of flies under long summer days. Our results provide a mechanistic model of light transduction and integration into the circadian system, identifying new and unexpected network motifs within the circadian clock neuron network. Copyright © 2016 the authors 0270-6474/16/369084-13$15.00/0.

Evaluation of terrestrial and streamside salamander monitoring techniques at Shenandoah National Park

USGS Publications Warehouse

Jung, R.E.; Droege, S.; Sauer, J.R.; Landy, R.B.

2000-01-01

In response to concerns about amphibian declines, a study evaluating and validating amphibian monitoring techniques was initiated in Shenandoah and Big Bend National Parks in the spring of 1998. We evaluate precision, bias, and efficiency of several sampling methods for terrestrial and streamside salamanders in Shenandoah National Park and assess salamander abundance in relation to environmental variables, notably soil and water pH. Terrestrial salamanders, primarily redback salamanders (Plethodon cinereus), were sampled by searching under cover objects during the day in square plots (10 to 35 m2). We compared population indices (mean daily and total counts) with adjusted population estimates from capture-recapture. Analyses suggested that the proportion of salamanders detected (p) during sampling varied among plots, necessitating the use of adjusted population estimates. However, adjusted population estimates were less precise than population indices, and may not be efficient in relating salamander populations to environmental variables. In future sampling, strategic use of capture-recapture to verify consistency of p's among sites may be a reasonable compromise between the possibility of bias in estimation of population size and deficiencies due to inefficiency associated with the estimation of p. The streamside two-lined salamander (Eurycea bislineata) was surveyed using four methods: leaf litter refugia bags, 1 m2 quadrats, 50 x 1 m visual encounter transects, and electric shocking. Comparison of survey methods at nine streams revealed congruent patterns of abundance among sites, suggesting that relative bias among the methods is similar, and that choice of survey method should be based on precision and logistical efficiency. Redback and two-lined salamander abundance were not significantly related to soil or water pH, respectively.

Interlaboratory comparison of three microbial source tracking quantitative polymerase chain reaction (qPCR) assays from fecal-source and environmental samples

USGS Publications Warehouse

Stelzer, Erin A.; Strickler, Kriston M.; Schill, William B.

2012-01-01

During summer and early fall 2010, 15 river samples and 6 fecal-source samples were collected in West Virginia. These samples were analyzed by three laboratories for three microbial source tracking (MST) markers: AllBac, a general fecal indicator; BacHum, a human-associated fecal indicator; and BoBac, a ruminant-associated fecal indicator. MST markers were analyzed by means of the quantitative polymerase chain reaction (qPCR) method. The aim was to assess interlaboratory precision when the three laboratories used the same MST marker and shared deoxyribonucleic acid (DNA) extracts of the samples, but different equipment, reagents, and analyst experience levels. The term assay refers to both the markers and the procedure differences listed above. Interlaboratory precision was best for all three MST assays when using the geometric mean absolute relative percent difference (ARPD) and Friedman's statistical test as a measure of interlaboratory precision. Adjustment factors (one for each MST assay) were calculated using results from fecal-source samples analyzed by all three laboratories and applied retrospectively to sample concentrations to account for differences in qPCR results among labs using different standards and procedures. Following the application of adjustment factors to qPCR results, ARPDs were lower; however, statistically significant differences between labs were still observed for the BacHum and BoBac assays. This was a small study and two of the MST assays had 52 percent of samples with concentrations at or below the limit of accurate quantification; hence, more testing could be done to determine if the adjustment factors would work better if the majority of sample concentrations were above the quantification limit.

Prediction of Individual Serum Infliximab Concentrations in Inflammatory Bowel Disease by a Bayesian Dashboard System.

PubMed

Eser, Alexander; Primas, Christian; Reinisch, Sieglinde; Vogelsang, Harald; Novacek, Gottfried; Mould, Diane R; Reinisch, Walter

2018-01-30

Despite a robust exposure-response relationship of infliximab in inflammatory bowel disease (IBD), attempts to adjust dosing to individually predicted serum concentrations of infliximab (SICs) are lacking. Compared with labor-intensive conventional software for pharmacokinetic (PK) modeling (eg, NONMEM) dashboards are easy-to-use programs incorporating complex Bayesian statistics to determine individual pharmacokinetics. We evaluated various infliximab detection assays and the number of samples needed to precisely forecast individual SICs using a Bayesian dashboard. We assessed long-term infliximab retention in patients being dosed concordantly versus discordantly with Bayesian dashboard recommendations. Three hundred eighty-two serum samples from 117 adult IBD patients on infliximab maintenance therapy were analyzed by 3 commercially available assays. Data from each assay was modeled using NONMEM and a Bayesian dashboard. PK parameter precision and residual variability were assessed. Forecast concentrations from both systems were compared with observed concentrations. Infliximab retention was assessed by prediction for dose intensification via Bayesian dashboard versus real-life practice. Forecast precision of SICs varied between detection assays. At least 3 SICs from a reliable assay are needed for an accurate forecast. The Bayesian dashboard performed similarly to NONMEM to predict SICs. Patients dosed concordantly with Bayesian dashboard recommendations had a significantly longer median drug survival than those dosed discordantly (51.5 versus 4.6 months, P < .0001). The Bayesian dashboard helps to assess the diagnostic performance of infliximab detection assays. Three, not single, SICs provide sufficient information for individualized dose adjustment when incorporated into the Bayesian dashboard. Treatment adjusted to forecasted SICs is associated with longer drug retention of infliximab. © 2018, The American College of Clinical Pharmacology.

Selective Hydrogen Isotope Separation via Breathing Transition in MIL-53(Al).

PubMed

Kim, Jin Yeong; Zhang, Linda; Balderas-Xicohténcatl, Rafael; Park, Jaewoo; Hirscher, Michael; Moon, Hoi Ri; Oh, Hyunchul

2017-12-13

Breathing of MIL-53(Al), a flexible metal-organic framework (MOF), leads to dynamic changes as narrow pore (np) transitions to large pore (lp). During the flexible and reversible transition, the pore apertures are continuously adjusted, thus providing the tremendous opportunity to separate mixtures of similar-sized and similar-shaped molecules that require precise pore tuning. Herein, for the first time, we report a strategy for effectively separating hydrogen isotopes through the dynamic pore change during the breathing of MIL-53(Al), a representative of flexible MOFs. The experiment shows that the selectivity for D 2 over H 2 is strongly related to the state of the pore structure of MIL-53(Al). The highest selectivity (S D 2 /H 2 = 13.6 at 40 K) was obtained by optimizing the exposure temperature, pressure, and time to systematically tune the pore state of MIL-53(Al).

Rapid and Facile Microwave-Assisted Surface Chemistry for Functionalized Microarray Slides

PubMed Central

Lee, Jeong Heon; Hyun, Hoon; Cross, Conor J.; Henary, Maged; Nasr, Khaled A.; Oketokoun, Rafiou; Choi, Hak Soo; Frangioni, John V.

2011-01-01

We describe a rapid and facile method for surface functionalization and ligand patterning of glass slides based on microwave-assisted synthesis and a microarraying robot. Our optimized reaction enables surface modification 42-times faster than conventional techniques and includes a carboxylated self-assembled monolayer, polyethylene glycol linkers of varying length, and stable amide bonds to small molecule, peptide, or protein ligands to be screened for binding to living cells. We also describe customized slide racks that permit functionalization of 100 slides at a time to produce a cost-efficient, highly reproducible batch process. Ligand spots can be positioned on the glass slides precisely using a microarraying robot, and spot size adjusted for any desired application. Using this system, we demonstrate live cell binding to a variety of ligands and optimize PEG linker length. Taken together, the technology we describe should enable high-throughput screening of disease-specific ligands that bind to living cells. PMID:23467787

Capabilities of unmanned aircraft vehicles for low altitude weed detection

NASA Astrophysics Data System (ADS)

Pflanz, Michael; Nordmeyer, Henning

2014-05-01

Sustainable crop production and food security require a consumer and environmental safe plant protection. It is recently known, that precise weed monitoring approaches could help apply pesticides corresponding to field variability. In this regard the site-specific weed management may contribute to an application of herbicides with higher ecologically aware and economical savings. First attempts of precision agriculture date back to the 1980's. Since that time, remote sensing from satellites or manned aircrafts have been investigated and used in agricultural practice, but are currently inadequate for the separation of weeds in an early growth stage from cultivated plants. In contrast, low-cost image capturing at low altitude from unmanned aircraft vehicles (UAV) provides higher spatial resolution and almost real-time processing. Particularly, rotary-wing aircrafts are suitable for precise path or stationary flight. This minimises motion blur and provides better image overlapping for stitching and mapping procedures. Through improved image analyses and the recent increase in the availability of microcontrollers and powerful batteries for UAVs, it can be expected that the spatial mapping of weeds will be enhanced in the future. A six rotors microcopter was equipped with a modified RGB camera taking images from agricultural fields. The hexacopter operates within predefined pathways at adjusted altitudes (from 5 to 10 m) by using GPS navigation. Different scenarios of optical weed detection have been carried out regarding to variable altitude, image resolution, weed and crop growth stages. Our experiences showed high capabilities for site-specific weed control. Image analyses with regard to recognition of weed patches can be used to adapt herbicide application to varying weed occurrence across a field.

Fundamental limits of scintillation detector timing precision

NASA Astrophysics Data System (ADS)

Derenzo, Stephen E.; Choong, Woon-Seng; Moses, William W.

2014-07-01

In this paper we review the primary factors that affect the timing precision of a scintillation detector. Monte Carlo calculations were performed to explore the dependence of the timing precision on the number of photoelectrons, the scintillator decay and rise times, the depth of interaction uncertainty, the time dispersion of the optical photons (modeled as an exponential decay), the photodetector rise time and transit time jitter, the leading-edge trigger level, and electronic noise. The Monte Carlo code was used to estimate the practical limits on the timing precision for an energy deposition of 511 keV in 3 mm × 3 mm × 30 mm Lu2SiO5:Ce and LaBr3:Ce crystals. The calculated timing precisions are consistent with the best experimental literature values. We then calculated the timing precision for 820 cases that sampled scintillator rise times from 0 to 1.0 ns, photon dispersion times from 0 to 0.2 ns, photodetector time jitters from 0 to 0.5 ns fwhm, and A from 10 to 10 000 photoelectrons per ns decay time. Since the timing precision R was found to depend on A-1/2 more than any other factor, we tabulated the parameter B, where R = BA-1/2. An empirical analytical formula was found that fit the tabulated values of B with an rms deviation of 2.2% of the value of B. The theoretical lower bound of the timing precision was calculated for the example of 0.5 ns rise time, 0.1 ns photon dispersion, and 0.2 ns fwhm photodetector time jitter. The lower bound was at most 15% lower than leading-edge timing discrimination for A from 10 to 10 000 photoelectrons ns-1. A timing precision of 8 ps fwhm should be possible for an energy deposition of 511 keV using currently available photodetectors if a theoretically possible scintillator were developed that could produce 10 000 photoelectrons ns-1.

Fundamental Limits of Scintillation Detector Timing Precision

PubMed Central

Derenzo, Stephen E.; Choong, Woon-Seng; Moses, William W.

2014-01-01

In this paper we review the primary factors that affect the timing precision of a scintillation detector. Monte Carlo calculations were performed to explore the dependence of the timing precision on the number of photoelectrons, the scintillator decay and rise times, the depth of interaction uncertainty, the time dispersion of the optical photons (modeled as an exponential decay), the photodetector rise time and transit time jitter, the leading-edge trigger level, and electronic noise. The Monte Carlo code was used to estimate the practical limits on the timing precision for an energy deposition of 511 keV in 3 mm × 3 mm × 30 mm Lu2SiO5:Ce and LaBr3:Ce crystals. The calculated timing precisions are consistent with the best experimental literature values. We then calculated the timing precision for 820 cases that sampled scintillator rise times from 0 to 1.0 ns, photon dispersion times from 0 to 0.2 ns, photodetector time jitters from 0 to 0.5 ns fwhm, and A from 10 to 10,000 photoelectrons per ns decay time. Since the timing precision R was found to depend on A−1/2 more than any other factor, we tabulated the parameter B, where R = BA−1/2. An empirical analytical formula was found that fit the tabulated values of B with an rms deviation of 2.2% of the value of B. The theoretical lower bound of the timing precision was calculated for the example of 0.5 ns rise time, 0.1 ns photon dispersion, and 0.2 ns fwhm photodetector time jitter. The lower bound was at most 15% lower than leading-edge timing discrimination for A from 10 to 10,000 photoelectrons/ns. A timing precision of 8 ps fwhm should be possible for an energy deposition of 511 keV using currently available photodetectors if a theoretically possible scintillator were developed that could produce 10,000 photoelectrons/ns. PMID:24874216

Precise GPS ephemerides from DMA and NGS tested by time transfer

NASA Technical Reports Server (NTRS)

Lewandowski, Wlodzimierz W.; Petit, Gerard; Thomas, Claudine

1992-01-01

It was shown that the use of the Defense Mapping Agency's (DMA) precise ephemerides brings a significant improvement to the accuracy of GPS time transfer. At present a new set of precise ephemerides produced by the National Geodetic Survey (NGS) has been made available to the timing community. This study demonstrates that both types of precise ephemerides improve long-distance GPS time transfer and remove the effects of Selective Availability (SA) degradation of broadcast ephemerides. The issue of overcoming SA is also discussed in terms of the routine availability of precise ephemerides.

Microgravity

NASA Image and Video Library

1994-07-10

TEMPUS, an electromagnetic levitation facility that allows containerless processing of metallic samples in microgravity, first flew on the IML-2 Spacelab mission. The principle of electromagnetic levitation is used commonly in ground-based experiments to melt and then cool metallic melts below their freezing points without solidification occurring. The TEMPUS operation is controlled by its own microprocessor system; although commands may be sent remotely from the ground and real time adjustments may be made by the crew. Two video cameras, a two-color pyrometer for measuring sample temperatures, and a fast infrared detector for monitoring solidification spikes, will be mounted to the process chamber to facilitate observation and analysis. In addition, a dedicated high-resolution video camera can be attached to the TEMPUS to measure the sample volume precisely.

A Plenoptic Multi-Color Imaging Pyrometer

NASA Technical Reports Server (NTRS)

Danehy, Paul M.; Hutchins, William D.; Fahringer, Timothy; Thurow, Brian S.

2017-01-01

A three-color pyrometer has been developed based on plenoptic imaging technology. Three bandpass filters placed in front of a camera lens allow separate 2D images to be obtained on a single image sensor at three different and adjustable wavelengths selected by the user. Images were obtained of different black- or grey-bodies including a calibration furnace, a radiation heater, and a luminous sulfur match flame. The images obtained of the calibration furnace and radiation heater were processed to determine 2D temperature distributions. Calibration results in the furnace showed that the instrument can measure temperature with an accuracy and precision of 10 Kelvins between 1100 and 1350 K. Time-resolved 2D temperature measurements of the radiation heater are shown.

Harmonizing Measures of Cognitive Performance Across International Surveys of Aging Using Item Response Theory.

PubMed

Chan, Kitty S; Gross, Alden L; Pezzin, Liliana E; Brandt, Jason; Kasper, Judith D

2015-12-01

To harmonize measures of cognitive performance using item response theory (IRT) across two international aging studies. Data for persons ≥65 years from the Health and Retirement Study (HRS, N = 9,471) and the English Longitudinal Study of Aging (ELSA, N = 5,444). Cognitive performance measures varied (HRS fielded 25, ELSA 13); 9 were in common. Measurement precision was examined for IRT scores based on (a) common items, (b) common items adjusted for differential item functioning (DIF), and (c) DIF-adjusted all items. Three common items (day of date, immediate word recall, and delayed word recall) demonstrated DIF by survey. Adding survey-specific items improved precision but mainly for HRS respondents at lower cognitive levels. IRT offers a feasible strategy for harmonizing cognitive performance measures across other surveys and for other multi-item constructs of interest in studies of aging. Practical implications depend on sample distribution and the difficulty mix of in-common and survey-specific items. © The Author(s) 2015.

Dynamic illumination of spatially restricted or large brain volumes via a single tapered optical fiber

PubMed Central

Pisanello, Marco; Oldenburg, Ian A.; Sileo, Leonardo; Markowitz, Jeffrey E.; Peterson, Ralph E.; Della Patria, Andrea; Haynes, Trevor M.; Emara, Mohamed S.; Spagnolo, Barbara; Datta, Sandeep Robert; De Vittorio, Massimo; Sabatini, Bernardo L.

2017-01-01

Optogenetics promises spatiotemporal precise control of neural processes using light. However, the spatial extent of illumination within the brain is difficult to control and cannot be adjusted using standard fiber optics. We demonstrate that optical fibers with tapered tips can be used to illuminate either spatially restricted or large brain volumes. Remotely adjusting the light input angle to the fiber varies the light-emitting portion of the taper over several millimeters without movement of the implant. We use this mode to activate dorsal versus ventral striatum of individual mice and reveal different effects of each manipulation on motor behavior. Conversely, injecting light over the full numerical aperture of the fiber results in light emission from the entire taper surface, achieving broader and more efficient optogenetic activation of neurons when compared to the standard flat-faced fiber stimulation. Thus, tapered fibers permit focal or broad illumination that can be precisely and dynamically matched to experimental needs. PMID:28628101

Dynamic illumination of spatially restricted or large brain volumes via a single tapered optical fiber.

PubMed

Pisanello, Ferruccio; Mandelbaum, Gil; Pisanello, Marco; Oldenburg, Ian A; Sileo, Leonardo; Markowitz, Jeffrey E; Peterson, Ralph E; Della Patria, Andrea; Haynes, Trevor M; Emara, Mohamed S; Spagnolo, Barbara; Datta, Sandeep Robert; De Vittorio, Massimo; Sabatini, Bernardo L

2017-08-01

Optogenetics promises precise spatiotemporal control of neural processes using light. However, the spatial extent of illumination within the brain is difficult to control and cannot be adjusted using standard fiber optics. We demonstrate that optical fibers with tapered tips can be used to illuminate either spatially restricted or large brain volumes. Remotely adjusting the light input angle to the fiber varies the light-emitting portion of the taper over several millimeters without movement of the implant. We use this mode to activate dorsal versus ventral striatum of individual mice and reveal different effects of each manipulation on motor behavior. Conversely, injecting light over the full numerical aperture of the fiber results in light emission from the entire taper surface, achieving broader and more efficient optogenetic activation of neurons, compared to standard flat-faced fiber stimulation. Thus, tapered fibers permit focal or broad illumination that can be precisely and dynamically matched to experimental needs.

Analysis of a piezoelectric power harvester with adjustable frequency by precise electric field method.

PubMed

Wang, Yujue; Lian, Ziyang; Yao, Mingge; Wang, Ji; Hu, Hongping

2013-10-01

A power harvester with adjustable frequency, which consists of a hinged-hinged piezoelectric bimorph and a concentrated mass, is studied by the precise electric field method (PEFM), taking into account a distribution of the electric field over the thickness. Usually, using the equivalent electric field method (EEFM), the electric field is approximated as a constant value in the piezoelectric layer. Charge on the upper electrode (UEC) of the bimorph is often assumed as output charge. However, different output charge can be obtained by integrating on electric displacement over the electrode with different thickness coordinates. Therefore, an average charge (AC) on thickness is often assumed as the output value. This method is denoted EEFM AC. The flexural vibration of the bimorph is calculated by the three methods and their results are compared. Numerical results illustrate that EEFM UEC overestimates resonant frequency, output power, and efficiency. EEFM AC can accurately calculate the output power and efficiency, but underestimates resonant frequency. The performance of the harvester, which depends on concentrated mass weight, position, and circuit load, is analyzed using PEFM. The resonant frequency can be modulated 924 Hz by moving the concentrated mass along the bimorph. This feature suggests that the natural frequency of the harvester can be adjusted conveniently to adapt to frequency fluctuation of the ambient vibration.

Regression discontinuity was a valid design for dichotomous outcomes in three randomized trials.

PubMed

van Leeuwen, Nikki; Lingsma, Hester F; Mooijaart, Simon P; Nieboer, Daan; Trompet, Stella; Steyerberg, Ewout W

2018-06-01

Regression discontinuity (RD) is a quasi-experimental design that may provide valid estimates of treatment effects in case of continuous outcomes. We aimed to evaluate validity and precision in the RD design for dichotomous outcomes. We performed validation studies in three large randomized controlled trials (RCTs) (Corticosteroid Randomization After Significant Head injury [CRASH], the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries [GUSTO], and PROspective Study of Pravastatin in elderly individuals at risk of vascular disease [PROSPER]). To mimic the RD design, we selected patients above and below a cutoff (e.g., age 75 years) randomized to treatment and control, respectively. Adjusted logistic regression models using restricted cubic splines (RCS) and polynomials and local logistic regression models estimated the odds ratio (OR) for treatment, with 95% confidence intervals (CIs) to indicate precision. In CRASH, treatment increased mortality with OR 1.22 [95% CI 1.06-1.40] in the RCT. The RD estimates were 1.42 (0.94-2.16) and 1.13 (0.90-1.40) with RCS adjustment and local regression, respectively. In GUSTO, treatment reduced mortality (OR 0.83 [0.72-0.95]), with more extreme estimates in the RD analysis (OR 0.57 [0.35; 0.92] and 0.67 [0.51; 0.86]). In PROSPER, similar RCT and RD estimates were found, again with less precision in RD designs. We conclude that the RD design provides similar but substantially less precise treatment effect estimates compared with an RCT, with local regression being the preferred method of analysis. Copyright © 2018 Elsevier Inc. All rights reserved.

RB Particle Filter Time Synchronization Algorithm Based on the DPM Model.

PubMed

Guo, Chunsheng; Shen, Jia; Sun, Yao; Ying, Na

2015-09-03

Time synchronization is essential for node localization, target tracking, data fusion, and various other Wireless Sensor Network (WSN) applications. To improve the estimation accuracy of continuous clock offset and skew of mobile nodes in WSNs, we propose a novel time synchronization algorithm, the Rao-Blackwellised (RB) particle filter time synchronization algorithm based on the Dirichlet process mixture (DPM) model. In a state-space equation with a linear substructure, state variables are divided into linear and non-linear variables by the RB particle filter algorithm. These two variables can be estimated using Kalman filter and particle filter, respectively, which improves the computational efficiency more so than if only the particle filter was used. In addition, the DPM model is used to describe the distribution of non-deterministic delays and to automatically adjust the number of Gaussian mixture model components based on the observational data. This improves the estimation accuracy of clock offset and skew, which allows achieving the time synchronization. The time synchronization performance of this algorithm is also validated by computer simulations and experimental measurements. The results show that the proposed algorithm has a higher time synchronization precision than traditional time synchronization algorithms.

Precision oncology: origins, optimism, and potential.

PubMed

Prasad, Vinay; Fojo, Tito; Brada, Michael

2016-02-01

Imatinib, the first and arguably the best targeted therapy, became the springboard for developing drugs aimed at molecular targets deemed crucial to tumours. As this development unfolded, a revolution in the speed and cost of genetic sequencing occurred. The result--an armamentarium of drugs and an array of molecular targets--set the stage for precision oncology, a hypothesis that cancer treatment could be markedly improved if therapies were guided by a tumour's genomic alterations. Drawing lessons from the biological basis of cancer and recent empirical investigations, we take a more measured view of precision oncology's promise. Ultimately, the promise is not our concern, but the threshold at which we declare success. We review reports of precision oncology alongside those of precision diagnostics and novel radiotherapy approaches. Although confirmatory evidence is scarce, these interventions have been widely endorsed. We conclude that the current path will probably not be successful or, at a minimum, will have to undergo substantive adjustments before it can be successful. For the sake of patients with cancer, we hope one form of precision oncology will deliver on its promise. However, until confirmatory studies are completed, precision oncology remains unproven, and as such, a hypothesis in need of rigorous testing. Copyright © 2016 Elsevier Ltd. All rights reserved.

Expertise for upright faces improves the precision but not the capacity of visual working memory.

PubMed

Lorenc, Elizabeth S; Pratte, Michael S; Angeloni, Christopher F; Tong, Frank

2014-10-01

Considerable research has focused on how basic visual features are maintained in working memory, but little is currently known about the precision or capacity of visual working memory for complex objects. How precisely can an object be remembered, and to what extent might familiarity or perceptual expertise contribute to working memory performance? To address these questions, we developed a set of computer-generated face stimuli that varied continuously along the dimensions of age and gender, and we probed participants' memories using a method-of-adjustment reporting procedure. This paradigm allowed us to separately estimate the precision and capacity of working memory for individual faces, on the basis of the assumptions of a discrete capacity model, and to assess the impact of face inversion on memory performance. We found that observers could maintain up to four to five items on average, with equally good memory capacity for upright and upside-down faces. In contrast, memory precision was significantly impaired by face inversion at every set size tested. Our results demonstrate that the precision of visual working memory for a complex stimulus is not strictly fixed but, instead, can be modified by learning and experience. We find that perceptual expertise for upright faces leads to significant improvements in visual precision, without modifying the capacity of working memory.

On-orbit figure sensing and figure correction control for 0.5 arc-second adjustable X-ray optics

NASA Astrophysics Data System (ADS)

Reid, Paul

This investigation seeks to develop the technology to directly monitor on-orbit changes to imaging performance of adjustable X-ray optics so as to be able to efficiently correct adverse changes at a level consistent with 0.5 arc-second X-ray telescope imaging. Adjustable X-ray optics employ thin film piezoelectric material deposited on the back of a thin glass Wolter mirror segment to introduce localized stresses in the mirror. These stresses are used in a deterministic way to improve mirror figure from 10 arc-sec, half power diameter (HPD), to 0.5 arc-sec, HPD, without the need for a heavy reaction structure. This is a realizable technology for potential future X-ray telescope missions with 0.5 arc-second resolution and several square meters effective area, such as SMART-X. We are pursuing such mirror development under an existing APRA grant. Here we propose a new investigation to accomplish the monitoring and control of the mirrors by monitoring the health of the piezoelectric actuators of the adjustable optics to a level consistent with 0.5 arcsec imaging. Such measurements are beyond the capability of conventional, thin metal film strain gauges using DC measurements. Instead, we propose to develop the technology to deposit different types of strain gauges (metal film, semiconductor) directly on the piezoelectric cells; to investigate the use of additional thin layers of piezoelectric materials such as lead zirconate titanate or zinc oxide as strain and temperature gauges; and to use AC measurement of strain gauges for precise measurement of piezoelectric adjuster performance. The intent is to use this information to correct changes in mirror shape by adjusting the voltages on the piezoelectric adjustors. Adjustable X-ray optics are designed to meet the challenge of large collecting area and high angular resolution. The mirrors are called adjustable rather than active as mirror figure error is corrected (adjusted) once or infrequently, as opposed to being changed constantly at several cycles/sec (active). In our approach, the mirror figure is corrected based on ground measurements, accounting for figure errors due to mirror manufacturing, mounting induced deformations, modeled gravity release, and modeled on-orbit thermal effects. The piezoelectric strain monitoring we seek to develop in this program extends adjustable mirror technology development, as it enables efficient adjustment and correction of mirror figure on-orbit, as required. This unprecedented level of system robustness will make telescopes less expensive to build because requirements for the non-optical systems can be looser, and it will also make the system more resistant to degradation, promoting mission success. The largest drivers for changes from ground calibration to on-orbit performance are piezoelectric material aging and an unexpected thermal environment (i.e., larger gradients than modeled or other thermal control system problem). Developing the capability to accurately monitor the health of each piezoelectric cell and the local mirror surface temperature will enable the real time sensing of any of these potential issues, help determine the cause, and enable corrections via updating models of on-orbit conditions and re-optimizing the required piezoelectric cell voltages for mirror figure correction. Our 3 year research program includes the development of the strain monitoring technology, its deposition on the adjustable optics, modeling and performance simulation, accelerated lifetime testing, and optical and electrical metrology of sample adjustable optics that incorporate monitoring sensors. Development of the capability to remotely monitor piezo performance and temperature to necessary precision will vastly improve reliability of the SMART-X mission concept, or the sub-arc-second X-ray Surveyor mission described in the 2013 NASA Astrophysics Roadmap, Enduring Quests Daring Visions.

Helical gears with circular arc teeth: Generation, geometry, precision and adjustment to errors, computer aided simulation of conditions of meshing and bearing contact

NASA Technical Reports Server (NTRS)

Litvin, Faydor L.; Tsay, Chung-Biau

1987-01-01

The authors have proposed a method for the generation of circular arc helical gears which is based on the application of standard equipment, worked out all aspects of the geometry of the gears, proposed methods for the computer aided simulation of conditions of meshing and bearing contact, investigated the influence of manufacturing and assembly errors, and proposed methods for the adjustment of gears to these errors. The results of computer aided solutions are illustrated with computer graphics.

Simultaneous determination of atenolol, chlorthalidone and amiloride in pharmaceutical preparations by capillary zone electrophoresis with ultraviolet detection.

PubMed

Al Azzam, Khaldun M; Saad, Bahruddin; Aboul-Enein, Hassan Y

2010-09-01

Capillary zone electrophoresis methods for the simultaneous determination of the beta-blocker drugs, atenolol, chlorthalidone and amiloride, in pharmaceutical formulations have been developed. The influences of several factors (buffer pH, concentration, applied voltage, capillary temperature and injection time) were studied. Using phenobarbital as internal standard, the analytes were all separated in less than 4 min. The separation was carried out in normal polarity mode at 25 degrees C, 25 kV and using hydrodynamic injection (10 s). The separation was effected in an uncoated fused-silica capillary (75 mum i.d. x 52 cm) and a background electrolyte of 25 mm H(3)PO(4) adjusted with 1 m NaOH solution (pH 9.0) and detection at 198 nm. The method was validated with respect to linearity, limit of detection and quantification, accuracy, precision and selectivity. Calibration curves were linear over the range 1-250 microg/mL for atenolol and chlorthalidone and from 2.5-250 microg/mL for amiloride. The relative standard deviations of intra- and inter-day migration times and corrected peak areas were less than 6.0%. The method showed good precision and accuracy and was successfully applied to the simultaneous determination of atenolol, chlorthalidone and amiloride in various pharmaceutical tablets formulations. 2010 John Wiley & Sons, Ltd.

Simulation Results for Airborne Precision Spacing along Continuous Descent Arrivals

NASA Technical Reports Server (NTRS)

Barmore, Bryan E.; Abbott, Terence S.; Capron, William R.; Baxley, Brian T.

2008-01-01

This paper describes the results of a fast-time simulation experiment and a high-fidelity simulator validation with merging streams of aircraft flying Continuous Descent Arrivals through generic airspace to a runway at Dallas-Ft Worth. Aircraft made small speed adjustments based on an airborne-based spacing algorithm, so as to arrive at the threshold exactly at the assigned time interval behind their Traffic-To-Follow. The 40 aircraft were initialized at different altitudes and speeds on one of four different routes, and then merged at different points and altitudes while flying Continuous Descent Arrivals. This merging and spacing using flight deck equipment and procedures to augment or implement Air Traffic Management directives is called Flight Deck-based Merging and Spacing, an important subset of a larger Airborne Precision Spacing functionality. This research indicates that Flight Deck-based Merging and Spacing initiated while at cruise altitude and well prior to the Terminal Radar Approach Control entry can significantly contribute to the delivery of aircraft at a specified interval to the runway threshold with a high degree of accuracy and at a reduced pilot workload. Furthermore, previously documented work has shown that using a Continuous Descent Arrival instead of a traditional step-down descent can save fuel, reduce noise, and reduce emissions. Research into Flight Deck-based Merging and Spacing is a cooperative effort between government and industry partners.

Tunnel profile measurement by vision metrology toward application to NATM

NASA Astrophysics Data System (ADS)

Hattori, Susumu; Akimoto, Keiichi; Ono, Tetsu; Miura, Satoru

2003-05-01

The NATM, a widely used tunnel excavation method, requires precise periodical monitoring of deformations especially at fault zones, which tends to hamper traffics with conventional measurement means. In this paper vision metrology was applied to tunnel profile measurement with a view to developing a new method. Two hundred of Retro-targets are placed on a one-meter spacing lattice at a tunnel site of 7m in diameter and 15m in longitude, and 66 images were taken to cover the target field. The object space coordinates of targets obtained by bundle adjustment were compared with ones obtained by high-precision total station observation. The root mean square (RMS) of differences of coordinates was 0.548mm, which is precise enough for monitoring deformations for the NATM.

Method of high precision interval measurement in pulse laser ranging system

NASA Astrophysics Data System (ADS)

Wang, Zhen; Lv, Xin-yuan; Mao, Jin-jin; Liu, Wei; Yang, Dong

2013-09-01

Laser ranging is suitable for laser system, for it has the advantage of high measuring precision, fast measuring speed,no cooperative targets and strong resistance to electromagnetic interference,the measuremen of laser ranging is the key paremeters affecting the performance of the whole system.The precision of the pulsed laser ranging system was decided by the precision of the time interval measurement, the principle structure of laser ranging system was introduced, and a method of high precision time interval measurement in pulse laser ranging system was established in this paper.Based on the analysis of the factors which affected the precision of range measure,the pulse rising edges discriminator was adopted to produce timing mark for the start-stop time discrimination,and the TDC-GP2 high precision interval measurement system based on TMS320F2812 DSP was designed to improve the measurement precision.Experimental results indicate that the time interval measurement method in this paper can obtain higher range accuracy. Compared with the traditional time interval measurement system,the method simplifies the system design and reduce the influence of bad weather conditions,furthermore,it satisfies the requirements of low costs and miniaturization.

An Exploratory Study of Runway Arrival Procedures: Time Based Arrival and Self-Spacing

NASA Technical Reports Server (NTRS)

Houston, Vincent E.; Barmore, Bryan

2009-01-01

The ability of a flight crew to deliver their aircraft to its arrival runway on time is important to the overall efficiency of the National Airspace System (NAS). Over the past several years, the NAS has been stressed almost to its limits resulting in problems such as airport congestion, flight delay, and flight cancellation to reach levels that have never been seen before in the NAS. It is predicted that this situation will worsen by the year 2025, due to an anticipated increase in air traffic operations to one-and-a-half to three times its current level. Improved arrival efficiency, in terms of both capacity and environmental impact, is an important part of improving NAS operations. One way to improve the arrival performance of an aircraft is to enable the flight crew to precisely deliver their aircraft to a specified point at either a specified time or specified interval relative to another aircraft. This gives the flight crew more control to make the necessary adjustments to their aircraft s performance with less tactical control from the controller; it may also decrease the controller s workload. Two approaches to precise time navigation have been proposed: Time-Based Arrivals (e.g., required times of arrival) and Self-Spacing. Time-Based Arrivals make use of an aircraft s Flight Management System (FMS) to deliver the aircraft to the runway threshold at a given time. Self-Spacing enables the flight crew to achieve an ATC assigned spacing goals at the runway threshold relative to another aircraft. The Joint Planning and Development Office (JPDO), a multi-agency initiative established to plan and coordinate the development of the Next Generation Air Transportation System (NextGen), has asked for data for both of these concepts to facilitate future research and development. This paper provides a first look at the delivery performance of these two concepts under various initial and environmental conditions in an air traffic simulation environment.

Totomatix: a novel automatic set-up to control diurnal, diel and long-term plant nitrate nutrition

PubMed Central

Adamowicz, Stéphane; Le Bot, Jacques; Huanosto Magaña, Ruth; Fabre, José

2012-01-01

Background Stand-alone nutritional set-ups are useful tools to grow plants at defined nutrient availabilities and to measure nutrient uptake rates continuously, in particular that for nitrate. Their use is essential when the measurements are meant to cover long time periods. These complex systems have, however, important drawbacks, including poor long-term reliability and low precision at high nitrate concentration. This explains why the information dealing with diel dynamics of nitrate uptake rate is scarce and concerns mainly young plants grown at low nitrate concentration. Scope The novel system detailed in this paper has been developed to allow versatile use in growth rooms, greenhouses or open fields at nitrate concentrations ranging from a few micro- to several millimoles per litres. The system controls, at set frequencies, the solution nitrate concentration, pH and volumes. Nitrate concentration is measured by spectral deconvolution of UV spectra. The main advantages of the set-up are its low maintenance (weekly basis), an ability to diagnose interference or erroneous analyses and high precision of nitrate concentration measurements (0·025 % at 3 mm). The paper details the precision of diurnal nitrate uptake rate measurements, which reveals sensitivity to solution volume at low nitrate concentration, whereas at high concentration, it is mostly sensitive to the precision of volume estimates. Conclusions This novel set-up allows us to measure and characterize the dynamics of plant nitrate nutrition at high temporal resolution (minutes to hours) over long-term experiments (up to 1 year). It is reliable and also offers a novel method to regulate up to seven N treatments by adjusting the daily uptake of test plants relative to controls, in variable environments such as open fields and glasshouses. PMID:21985796

Adjusting for publication biases across similar interventions performed well when compared with gold standard data.

PubMed

Moreno, Santiago G; Sutton, Alex J; Ades, A E; Cooper, Nicola J; Abrams, Keith R

2011-11-01

To extend, apply, and evaluate a regression-based approach to adjusting meta-analysis for publication and related biases. The approach uses related meta-analyses to improve estimation by borrowing strength on the degree of bias. The proposed adjustment approach is described. Adjustments are applied both independently and by borrowing strength across journal-extracted data on the effectiveness of 12 antidepressant drugs from placebo-controlled trials. The methods are also applied to Food and Drug Administration (FDA) data obtained on the same 12 drugs. Results are compared, viewing the FDA observed data as gold standard. Estimates adjusted for publication biases made independently for each drug were very uncertain using both the journal and FDA data. Adjusted estimates were much more precise when borrowing strength across meta-analyses. Reassuringly, adjustments in this way made to the journal data agreed closely with the observed estimates from the FDA data, while the adjusted FDA results changed only minimally from those observed from the FDA data. The method worked well in the case study considered and therefore further evaluation is encouraged. It is suggested that this approach may be especially useful when adjusting several meta-analyses on similar interventions and outcomes, particularly when there are small numbers of studies. Copyright © 2011 Elsevier Inc. All rights reserved.

Separation of atmospheric, oceanic and hydrological polar motion excitation mechanisms based on a combination of geometric and gravimetric space observations

NASA Astrophysics Data System (ADS)

Göttl, F.; Schmidt, M.; Seitz, F.; Bloßfeld, M.

2015-04-01

The goal of our study is to determine accurate time series of geophysical Earth rotation excitations to learn more about global dynamic processes in the Earth system. For this purpose, we developed an adjustment model which allows to combine precise observations from space geodetic observation systems, such as Satellite Laser Ranging (SLR), Global Navigation Satellite Systems, Very Long Baseline Interferometry, Doppler Orbit determination and Radiopositioning Integrated on Satellite, satellite altimetry and satellite gravimetry in order to separate geophysical excitation mechanisms of Earth rotation. Three polar motion time series are applied to derive the polar motion excitation functions (integral effect). Furthermore we use five time variable gravity field solutions from Gravity Recovery and Climate Experiment to determine not only the integral mass effect but also the oceanic and hydrological mass effects by applying suitable filter techniques and a land-ocean mask. For comparison the integral mass effect is also derived from degree 2 potential coefficients that are estimated from SLR observations. The oceanic mass effect is also determined from sea level anomalies observed by satellite altimetry by reducing the steric sea level anomalies derived from temperature and salinity fields of the oceans. Due to the combination of all geodetic estimated excitations the weaknesses of the individual processing strategies can be reduced and the technique-specific strengths can be accounted for. The formal errors of the adjusted geodetic solutions are smaller than the RMS differences of the geophysical model solutions. The improved excitation time series can be used to improve the geophysical modeling.

Reliability of conventional shade guides in teeth color determination.

PubMed

Todorović, Ana; Todorović, Aleksandar; Gostović, Aleksandra Spadijer; Lazić, Vojkan; Milicić, Biljana; Djurisić, Slobodan

2013-10-01

Color matching in prosthodontic therapy is a very important task because it influences the esthetic value of dental restorations. Visual shade matching represents the most frequently applied method in clinical practice. Instrumental measurements provide objective and quantified data in color assessment of natural teeth and restorations. In instrumental shade analysis, the goal is to achieve the smallest deltaE value possible, indicating the most accurate shade match. The aim of this study was to evaluate the reliability of commercially available ceramic shade guides. VITA Easyshade spectrophotometer (VITA, Germany) was used for instrumental color determination. Utilizing this device, color samples of ten VITA Classical and ten VITA 3D - Master shade guides were analyzed. Each color sample from all shade guides was measured three times and the basic parameters of color quality were examined: deltaL, deltaC, deltaH, deltaE, deltaElc. Based on these parameters spectrophotometer marks the shade matching as good, fair or adjust. After performing 1,248 measurements of ceramic color samples, frequency of evaluations adjust, fair and good were statistically significantly different between VITA Classical and VITA 3D Master shade guides (p = 0.002). There were 27.1% cases scored as adjust, 66.3% as fair and 6.7% as good. In VITA 3D - Master shade guides 30.9% cases were evaluated as adjust, 66.4% as fair and 2.7% cases as good. Color samples from different shade guides, produced by the same manufacturer, show variability in basic color parameters, which once again proves the lack of precision and nonuniformity of the conventional method.

Real time relationship between individual finger force and grip exertion on distal phalanges in linear force following tasks.

PubMed

Luo, Shi-Jian; Shu, Ge; Gong, Yan

2018-05-01

Individual finger force (FF) in a grip task is a vital concern in rehabilitation engineering and precise control of manipulators because disorders in any of the fingers will affect the stability or accuracy of the grip force (GF). To understand the functions of each finger in a dynamic grip exertion task, a GF following experiment with four individual fingers without thumb was designed. This study obtained four individual FFs from the distal phalanges with a cylindrical handle in dynamic GF following tasks. Ten healthy male subjects with similar hand sizes participated in the four-finger linear GF following tasks at different submaximal voluntary contraction (SMVC) levels. The total GF, individual FF, finger force contribution, and following error were subsequently calculated and analyzed. The statistics indicated the following: 1) the accuracy and stability of GF at low %MVC were significantly higher than those at high SMVC; 2) at low SMVC, the ability of the fingers to increase the GF was better than the ability to reduce it, but it was contrary at high SMVC; 3) when the target wave (TW) was changing, all four fingers strongly participated in the force exertion, but the participation of the little finger decreased significantly when TW remained stable; 4) the index finger and ring finger had a complementary relationship and played a vital role in the adjustment and control of GF. The middle finger and little finger had a minor influence on the force control and adjustment. In conclusion, each of the fingers had different functions in a GF following task. These findings can be used in the assessment of finger injury rehabilitation and for algorithms of precise control. Copyright © 2017 Elsevier Ltd. All rights reserved.

Dynamically formed admicelle layer to control the amplitude of cathodic electroosmotic flow.

PubMed

Erny, Guillaume L; Gonçalves, Bruna M; Esteves, Valdemar I

2012-09-21

In this manuscript, a method to precisely adjust the amplitude of a cathodic electroosmotic flow is described. The method uses a capillary pre-coated with a cationic polymer (polybrene), in presence of an anionic surfactant such as sodium dodecyl sulfate. At low concentration of surfactant, molecules will self-assemble to form an immobilized hemimicelle layer with the anionic "head" in contact with the cationic coating and the hydrophobic tail reaching into the background electrolyte. At higher concentration, surfactant molecules in solution will then interact, via hydrophobic interactions, to form an admicelle layer. It has been demonstrated that the admicelle layer can be constructed with either pure anionic surfactant (SDS), or a mixture of anionic and neutral surfactants. Admicelle coatings can be used to control the electroosmotic flow (EOF). While at low surfactant concentration the amplitude of the EOF depends on the concentration of the surfactants concentration, when this concentration reaches the critical admicelle concentration the EOF becomes near constant. The amplitude of the EOF can also be adjusted via the relative proportion of neutral and ionic surfactant in solution. Using this approach, the EOF was varied from 0.450 to 3.848 × 10(-8)m(2)V(-1)s(-1) with a precision below 0.050 × 10(-8)m(2)V(-1)s(-1) (standard deviation measured with three replicates). The coating has been tested using a mix of triazines (atrazine, simazine and terbuthylazine) and a beer sample. With the beer sample an average relative standard deviation of 1.5% for the migration time and of 2.2% for the corrected peak area was obtained. Copyright © 2012 Elsevier B.V. All rights reserved.

A rack-mounted precision waveguide-below-cutoff attenuator with an absolute electronic readout

NASA Technical Reports Server (NTRS)

Cook, C. C.

1974-01-01

A coaxial precision waveguide-below-cutoff attenuator is described which uses an absolute (unambiguous) electronic digital readout of displacement in inches in addition to the usual gear driven mechanical counter-dial readout in decibels. The attenuator is rack-mountable and has the input and output RF connectors in a fixed position. The attenuation rate for 55, 50, and 30 MHz operation is given along with a discussion of sources of errors. In addition, information is included to aid the user in making adjustments on the attenuator should it be damaged or disassembled for any reason.

Precision technique for trimming dies using a magnification device.

PubMed

Beck, D B

1980-05-01

This article described a technique for trimming a die under magnification. However, the microscope is also useful for checking (1) margins of wax patterns for completeness, (2) the internal surfaces of castings for imperfections, bubbles, or retained investment particles which could prevent proper seating of the castings on the dies, (3) for cracks or contamination in dental porcelain as well as porcelain flash on margins; and (4) precision attachment operation after casting or soldering procedures. Attention to detail in these laboratory procedures greatly improves the final fit of dental castings and saves subsequent chairside adjustments and remakes.

Precise Time - Naval Oceanography Portal

Science.gov Websites

section Advanced Search... Sections Home Time Earth Orientation Astronomy Meteorology Oceanography Ice You are here: Home › USNO › Precise Time USNO Logo USNO Navigation Master Clock GPS Display Clocks TWSTT Telephone Time NTP Info Precise Time The U. S. Naval Observatory is charged with maintaining the

Real Time Precise Point Positioning: Preliminary Results for the Brazilian Region

NASA Astrophysics Data System (ADS)

Marques, Haroldo; Monico, João.; Hirokazu Shimabukuro, Milton; Aquino, Marcio

2010-05-01

GNSS positioning can be carried out in relative or absolute approach. In the last years, more attention has been driven to the real time precise point positioning (PPP). To achieve centimeter accuracy with this method in real time it is necessary to have available the satellites precise coordinates as well as satellites clocks corrections. The coordinates can be used from the predicted IGU ephemeris, but the satellites clocks must be estimated in a real time. It can be made from a GNSS network as can be seen from EUREF Permanent Network. The infra-structure to realize the PPP in real time is being available in Brazil through the Brazilian Continuous Monitoring Network (RBMC) together with the Sao Paulo State GNSS network which are transmitting GNSS data using NTRIP (Networked Transport of RTCM via Internet Protocol) caster. Based on this information it was proposed a PhD thesis in the Univ. Estadual Paulista (UNESP) aiming to investigate and develop the methodology to estimate the satellites clocks and realize PPP in real time. Then, software is being developed to process GNSS data in the real time PPP mode. A preliminary version of the software was called PPP_RT and is able to process GNSS code and phase data using precise ephemeris and satellites clocks. The PPP processing can be accomplished considering the absolute satellite antenna Phase Center Variation (PCV), Ocean Tide Loading (OTL), Earth Body Tide, among others. The first order ionospheric effects can be eliminated or minimized by ion-free combination or parameterized in the receiver-satellite direction using a stochastic process, e.g. random walk or white noise. In the case of ionosphere estimation, a pseudo-observable is introduced in the mathematical model for each satellite and the initial value can be computed from Klobuchar model or from Global Ionospheric Map (GIM). The adjustment is realized in the recursive mode and the DIA (Detection Identification and Adaptation) is used for quality control. In this paper our proposition is to present the mathematical models implemented in the PPP_RT software and some proposal to accomplish the PPP in real time as for example using tropospheric model from Brazilian Numerical Weather Forecast Model (BNWFM) and estimating the ionosphere using stochastic process. GPS data sample from the Brazilian region was processed using the PPP_RT software considering periods under low and high ionospheric activities and the results estimating the ionosphere were compared with the ion-free combination. The PPP results also were analyzed considering the strategy of the troposphere estimation, Hopfield model or using the BNWFM. For the troposphere case, the values from BNWFM can reach similar results when estimating the troposphere. For the ionosphere case, the results have shown that ionosphere estimation can improve the time convergence of the PPP processing what is very important for PPP in real time.

Mechanical design and analysis of focal plate for gravity deformation

NASA Astrophysics Data System (ADS)

Wang, Jianping; Chu, Jiaru; Hu, Hongzhuan; Li, Kexuan; Zhou, Zengxiang

2014-07-01

The surface accuracy of astronomical telescope focal plate is a key indicator to precision stellar observation. To conduct accurate deformation measurement for focal plate in different status, a 6-DOF hexapod platform was used for attitude adjustment. For the small adjustment range of a classic 6-DOF hexapod platform, an improved structural arrangement method was proposed in the paper to achieve ultimate adjustment of the focal plate in horizontal and vertical direction. To validate the feasibility of this method, an angle change model which used ball hinge was set up for the movement and base plate. Simulation results in MATLAB suggested that the ball hinge angle change of movement and base plate is within the range of the limiting angle in the process of the platform plate adjusting to ultimate attitude. The proposed method has some guiding significance for accurate surface measurement of focal plate.

Adjusting an electron beam for drilling

NASA Technical Reports Server (NTRS)

Childress, C. L.

1980-01-01

Reticle contains two concentric circles: inner circle insures beam circularity and outer circle is guide to prevent beam from cutting workpiece clamp. Precise measurement of beam and clamp are required with old reticle. New reticle speeds up electron-beam drilling process by eliminating need to rotate eyepiece to make measurements against reticle scale.

Results of wind simulations in the mesosphere using precision C-band radars and the inflatable falling sphere technique

NASA Technical Reports Server (NTRS)

Schmidlin, F. J.; Northam, E. T.; Michel, W. R.

1985-01-01

The inflatable sphere technique represents a relatively inexpensive approach for obtaining density and wind data between 30 and 90 km. The procedure in its current form is adequate for operational rocket network type application. However, detailed information is lost because of oversmoothing. The present study had the objective to determine whether more detailed wind profiles could be obtained using the inflatable falling sphere and Hirobin. Hirobin is the name for the sphere reduction program used at NASA Wallops Island, VA. In connection with the aim of the study, information had to be obtained regarding the precision of the radar used to track the sphere. For this purpose, data from three C-band radars, each with a different tracking precision, were simulated. On the basis of the results of the investigation, it is concluded that, given a radar with a known precision and a perfectly performing sphere, the Hirobin filters can be adjusted to provide small-scale wind information to about 70 km.

Personalized medicine and chronic obstructive pulmonary disease.

PubMed

Wouters, E F M; Wouters, B B R A F; Augustin, I M L; Franssen, F M E

2017-05-01

The current review summarizes ongoing developments in personalized medicine and precision medicine in chronic obstructive pulmonary disease (COPD). Our current approach is far away of personalized management algorithms as current recommendations for COPD are largely based on a reductionist disease description, operationally defined by results of spirometry. Besides precision medicine developments, a personalized medicine approach in COPD is described based on a holistic approach of the patient and considering illness as the consequence of dynamic interactions within and between multiple interacting and self-adjusting systems. Pulmonary rehabilitation is described as a model of personalized medicine. Largely based on current understanding of inflammatory processes in COPD, targeted interventions in COPD are reviewed. Augmentation therapy for α-1-antitrypsine deficiency is described as model of precision medicine in COPD based in profound understanding of the related genetic endotype. Future developments of precision medicine in COPD require identification of relevant endotypes combined with proper identification of phenotypes involved in the complex and heterogeneous manifestations of COPD.

Air Traffic Management Technology Demostration: 1 Research and Procedural Testing of Routes

NASA Technical Reports Server (NTRS)

Wilson, Sara R.; Kibler, Jennifer L.; Hubbs, Clay E.; Smail, James W.

2015-01-01

NASA's Air Traffic Management Technology Demonstration-1 (ATD-1) will operationally demonstrate the feasibility of efficient arrival operations combining ground-based and airborne NASA technologies. The ATD-1 integrated system consists of the Traffic Management Advisor with Terminal Metering which generates precise time-based schedules to the runway and merge points; Controller Managed Spacing decision support tools which provide controllers with speed advisories and other information needed to meet the schedule; and Flight deck-based Interval Management avionics and procedures which allow flight crews to adjust their speed to achieve precise relative spacing. Initial studies identified air-ground challenges related to the integration of these three scheduling and spacing technologies, and NASA's airborne spacing algorithm was modified to address some of these challenges. The Research and Procedural Testing of Routes human-in-the-loop experiment was then conducted to assess the performance of the new spacing algorithm. The results of this experiment indicate that the algorithm performed as designed, and the pilot participants found the airborne spacing concept, air-ground procedures, and crew interface to be acceptable. However, the researchers concluded that the data revealed issues with the frequency of speed changes and speed reversals.

RP-HPLC method development and validation for simultaneous estimation of atorvastatin calcium and pioglitazone hydrochloride in pharmaceutical dosage form.

PubMed

Peraman, Ramalingam; Mallikarjuna, Sasikala; Ammineni, Pravalika; Kondreddy, Vinod kumar

2014-10-01

A simple, selective, rapid, precise and economical reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for simultaneous estimation of atorvastatin calcium (ATV) and pioglitazone hydrochloride (PIO) from pharmaceutical formulation. The method is carried out on a C8 (25 cm × 4.6 mm i.d., 5 μm) column with a mobile phase consisting of acetonitrile (ACN):water (pH adjusted to 6.2 using o-phosphoric acid) in the ratio of 45:55 (v/v). The retention time of ATV and PIO is 4.1 and 8.1 min, respectively, with the flow rate of 1 mL/min with diode array detector detection at 232 nm. The linear regression analysis data from the linearity plot showed good linear relationship with a correlation coefficient (R(2)) value for ATV and PIO of 0.9998 and 0.9997 in the concentration range of 10-80 µg mL(-1), respectively. The relative standard deviation for intraday precision has been found to be <2.0%. The method is validated according to the ICH guidelines. The developed method is validated in terms of specificity, selectivity, accuracy, precision, linearity, limit of detection, limit of quantitation and solution stability. The proposed method can be used for simultaneous estimation of these drugs in marketed dosage forms. © The Author [2013]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Smart portable rehabilitation devices.

PubMed

Mavroidis, Constantinos; Nikitczuk, Jason; Weinberg, Brian; Danaher, Gil; Jensen, Katherine; Pelletier, Philip; Prugnarola, Jennifer; Stuart, Ryan; Arango, Roberto; Leahey, Matt; Pavone, Robert; Provo, Andrew; Yasevac, Dan

2005-07-12

The majority of current portable orthotic devices and rehabilitative braces provide stability, apply precise pressure, or help maintain alignment of the joints with out the capability for real time monitoring of the patient's motions and forces and without the ability for real time adjustments of the applied forces and motions. Improved technology has allowed for advancements where these devices can be designed to apply a form of tension to resist motion of the joint. These devices induce quicker recovery and are more effective at restoring proper biomechanics and improving muscle function. However, their shortcoming is in their inability to be adjusted in real-time, which is the most ideal form of a device for rehabilitation. This introduces a second class of devices beyond passive orthotics. It is comprised of "active" or powered devices, and although more complicated in design, they are definitely the most versatile. An active or powered orthotic, usually employs some type of actuator(s). In this paper we present several new advancements in the area of smart rehabilitation devices that have been developed by the Northeastern University Robotics and Mechatronics Laboratory. They are all compact, wearable and portable devices and boast re-programmable, real time computer controlled functions as the central theme behind their operation. The sensory information and computer control of the three described devices make for highly efficient and versatile systems that represent a whole new breed in wearable rehabilitation devices. Their applications range from active-assistive rehabilitation to resistance exercise and even have applications in gait training. The three devices described are: a transportable continuous passive motion elbow device, a wearable electro-rheological fluid based knee resistance device, and a wearable electrical stimulation and biofeedback knee device. Laboratory tests of the devices demonstrated that they were able to meet their design objectives. The prototypes of portable rehabilitation devices presented here did demonstrate that these concepts are capable of the performance their commercially available but non-portable counterparts exhibit. Smart, portable devices with the ability for real time monitoring and adjustment open a new era in rehabilitation where the recovery process could be dramatically improved.

Smart portable rehabilitation devices

PubMed Central

Mavroidis, Constantinos; Nikitczuk, Jason; Weinberg, Brian; Danaher, Gil; Jensen, Katherine; Pelletier, Philip; Prugnarola, Jennifer; Stuart, Ryan; Arango, Roberto; Leahey, Matt; Pavone, Robert; Provo, Andrew; Yasevac, Dan

2005-01-01

Background The majority of current portable orthotic devices and rehabilitative braces provide stability, apply precise pressure, or help maintain alignment of the joints with out the capability for real time monitoring of the patient's motions and forces and without the ability for real time adjustments of the applied forces and motions. Improved technology has allowed for advancements where these devices can be designed to apply a form of tension to resist motion of the joint. These devices induce quicker recovery and are more effective at restoring proper biomechanics and improving muscle function. However, their shortcoming is in their inability to be adjusted in real-time, which is the most ideal form of a device for rehabilitation. This introduces a second class of devices beyond passive orthotics. It is comprised of "active" or powered devices, and although more complicated in design, they are definitely the most versatile. An active or powered orthotic, usually employs some type of actuator(s). Methods In this paper we present several new advancements in the area of smart rehabilitation devices that have been developed by the Northeastern University Robotics and Mechatronics Laboratory. They are all compact, wearable and portable devices and boast re-programmable, real time computer controlled functions as the central theme behind their operation. The sensory information and computer control of the three described devices make for highly efficient and versatile systems that represent a whole new breed in wearable rehabilitation devices. Their applications range from active-assistive rehabilitation to resistance exercise and even have applications in gait training. The three devices described are: a transportable continuous passive motion elbow device, a wearable electro-rheological fluid based knee resistance device, and a wearable electrical stimulation and biofeedback knee device. Results Laboratory tests of the devices demonstrated that they were able to meet their design objectives. The prototypes of portable rehabilitation devices presented here did demonstrate that these concepts are capable of the performance their commercially available but non-portable counterparts exhibit. Conclusion Smart, portable devices with the ability for real time monitoring and adjustment open a new era in rehabilitation where the recovery process could be dramatically improved. PMID:16011801

Creation of economical and robust large area MCPs by ALD method for photodetectors

NASA Astrophysics Data System (ADS)

Mane, Anil U.; Elam, Jeffrey W.; Wagner, Robert G.; Siegmund, Oswald H. W.; Minot, Michael J.

2016-09-01

We report a cost-effective and production achievable path to fabricate robust large-area microchannel plates (MCPs), which offers the new prospect for larger area MCP-based detector technologies. We used atomic Layer Deposition (ALD), a thin film growth technique, to independently adjust the desired electrical resistance and secondary electron emission (SEE) properties of low cost borosilicate glass micro-capillary arrays (MCAs). These capabilities allow a separation of the substrate material properties from the signal amplification properties. This methodology enables the functionalization of microporous, highly insulating MCA substrates to produce sturdy, large format MCPs with unique properties such as high gain (<107/MCP pair), low background noise, 10ps time resolution, sub-micron spatial resolution and excellent stability after only a short (2-3days) scrubbing time. The ALD self-limiting growth mechanism allows atomic level control over the thickness and composition of resistive and secondary electron emission (SEE) layers that can be deposited conformally on high aspect ratio ( 100) capillary glass arrays. We have developed several robust and consistent production doable ALD processes for the resistive coatings and SEE layers to give us precise control over the MCP parameters. Further, the adjustment of MCPs resistance by tailoring the ALD material composition permits the use of these MCPs at high or low temperature detector applications. Here we discuss ALD method for MCP functionalization and a variety of MCP testing results.

Theoretical and experimental investigation of position-controlled semi-active friction damper for seismic structures

NASA Astrophysics Data System (ADS)

Lu, Lyan-Ywan; Lin, Tzu-Kang; Jheng, Rong-Jie; Wu, Hsin-Hsien

2018-01-01

A semi-active friction damper (SAFD) can be employed for the seismic protection of structural systems. The effectiveness of an SAFD in absorbing seismic energy is usually superior to that of its passive counterpart, since its slip force can be altered in real time according to structural response and excitation. Most existing SAFDs are controlled by adjusting the clamping force applied on the friction interface. Thus, the implementation of SAFDs in practice requires precision control of the clamping force, which is usually substantially larger than the slip force. This may increase the implementation complexity and cost of SAFDs. To avoid this problem, this study proposes a novel position-controlled SAFD, named the leverage-type controllable friction damper (LCFD). The LCFD system combines a traditional passive friction damper and a leverage mechanism with a movable central pivot. By simply controlling the pivot position, the damping force generated by the LCFD system can be adjusted in real time. In order to verify the feasibility of the proposed SAFD, a prototype LCFD was tested by using a shaking table. The test results demonstrate that the equivalent friction force and hysteresis loop of the LCFD can be regulated by controlling the pivot position. By considering 16 ground motions with two different intensities, the adaptive feature of the LCFD for seismic structural control is further demonstrated numerically.

Proportional spike-timing precision and firing reliability underlie efficient temporal processing of periodicity and envelope shape cues

PubMed Central

Zheng, Y.

2013-01-01

Temporal sound cues are essential for sound recognition, pitch, rhythm, and timbre perception, yet how auditory neurons encode such cues is subject of ongoing debate. Rate coding theories propose that temporal sound features are represented by rate tuned modulation filters. However, overwhelming evidence also suggests that precise spike timing is an essential attribute of the neural code. Here we demonstrate that single neurons in the auditory midbrain employ a proportional code in which spike-timing precision and firing reliability covary with the sound envelope cues to provide an efficient representation of the stimulus. Spike-timing precision varied systematically with the timescale and shape of the sound envelope and yet was largely independent of the sound modulation frequency, a prominent cue for pitch. In contrast, spike-count reliability was strongly affected by the modulation frequency. Spike-timing precision extends from sub-millisecond for brief transient sounds up to tens of milliseconds for sounds with slow-varying envelope. Information theoretic analysis further confirms that spike-timing precision depends strongly on the sound envelope shape, while firing reliability was strongly affected by the sound modulation frequency. Both the information efficiency and total information were limited by the firing reliability and spike-timing precision in a manner that reflected the sound structure. This result supports a temporal coding strategy in the auditory midbrain where proportional changes in spike-timing precision and firing reliability can efficiently signal shape and periodicity temporal cues. PMID:23636724

Proceedings of the Fourth Precise Time and Time Interval Planning Meeting

NASA Technical Reports Server (NTRS)

Acrivos, H. N. (Compiler); Wardrip, S. C. (Compiler)

1972-01-01

The proceedings of a conference on Precise Time and Time Interval Planning are presented. The subjects discussed include the following: (1) satellite timing techniques, precision frequency sources, and very long baseline interferometry, (2) frequency stabilities and communications, and (3) very low frequency and ultrahigh frequency propagation and use. Emphasis is placed on the accuracy of time discrimination obtained with time measuring equipment and specific applications of time measurement to military operations and civilian research projects.

Acquisition and retention of laparoscopic skills is different comparing conventional laparoscopic and single-incision laparoscopic surgery: a single-centre, prospective randomized study.

PubMed

Ellis, Scott Michael; Varley, Martin; Howell, Stuart; Trochsler, Markus; Maddern, Guy; Hewett, Peter; Runge, Tina; Mees, Soeren Torge

2016-08-01

Training in laparoscopic surgery is important not only to acquire and improve skills but also avoid the loss of acquired abilities. The aim of this single-centre, prospective randomized study was to assess skill acquisition of different laparoscopic techniques and identify the point in time when acquired skills deteriorate and training is needed to maintain these skills. Sixty surgical novices underwent laparoscopic surgery (LS) and single-incision laparoscopic surgery (SILS) baseline training (BT) performing two validated tasks (peg transfer, precision cutting). The novices were randomized into three groups and skills retention testing (RT) followed after 8 (group A), 10 (group B) or 12 (group C) weeks accordingly. Task performance was measured in time with time penalties for insufficient task completion. 92 % of the participants completed the BT and managed to complete the task in the required time frame of proficiency. Univariate and multivariate analyses revealed that SILS (P < 0.0001) and precision cutting (P < 0.0001) were significantly more difficult. Males performed significantly better than females (P < 0.005). For LS, a deterioration of skills (comparison of BT vs RT) was not identified; however, for SILS a significant deterioration of skills (adjustment of BT and RT values) was demonstrated for all groups (A-C) (P < 0.05). Our data reveal that complex laparoscopic tasks (cutting) and techniques (SILS) are more difficult to learn and acquired skills more difficult to maintain. Acquired LS skills were maintained for the whole observation period of 12 weeks but SILS skills had begun to deteriorate at 8 weeks. These data show that maintenance of LS and SILS skills is divergent and training curricula need to take these specifics into account.

Clinical development of BLZ-100 for real-time optical imaging of tumors during resection

NASA Astrophysics Data System (ADS)

Franklin, Heather L.; Miller, Dennis M.; Hedges, Teresa; Perry, Jeff; Parrish-Novak, Julia

2016-03-01

Complete initial resection can give cancer patients the best opportunity for long-term survival. There is unmet need in surgical oncology for optical imaging that enables simple and precise visualization of tumors and consistent contrast with surrounding normal tissues. Near-infrared (NIR) contrast agents and camera systems that can detect them represent an area of active research and development. The investigational Tumor Paint agent BLZ-100 is a conjugate of a chlorotoxin peptide and the NIR dye indocyanine green (ICG) that has been shown to specifically bind to a broad range of solid tumors. Clinical efficacy studies with BLZ-100 are in progress, a necessary step in bringing the product into clinical practice. To ensure a product that will be useful for and accepted by surgeons, the early clinical development of BLZ- 100 incorporates multiple tumor types and imaging devices so that surgeon feedback covers the range of anticipated clinical uses. Key contrast agent characteristics include safety, specificity, flexibility in timing between dose and surgery, and breadth of tumor types recognized. Imaging devices should use wavelengths that are optimal for the contrast agent, be sensitive enough that contrast agent dosing can be adjusted for optimal contrast, include real-time video display of fluorescence and white light image, and be simple for surgeons to use with minimal disruption of surgical flow. Rapid entry into clinical studies provides the best opportunity for early surgeon feedback, enabling development of agents and devices that will gain broad acceptance and provide information that helps surgeons achieve more complete and precise resections.

Proceedings of the 7th Annual Precise Time and Time Interval (PTTI) Applications and Planning Meeting

NASA Technical Reports Server (NTRS)

1975-01-01

The Proceedings contain the papers presented at the Seventh Annual Precise Time and Time Interval (PTTI) Applications and Planning Meeting and the edited record of the discussion period following each paper. This meeting provided a forum to promote more effective, efficient, economical and skillful applications of PTTI technology to the many problem areas to which PTTI offers solutions. Specifically the purpose of the meeting is to: disseminate, coordinate, and exchange practical information associated with precise time and frequency; acquaint systems engineers, technicians and managers with precise time and frequency technology and its applications; and review present and future requirements for PTTI.

Precise control of photoinduced birefringence in azobenzene-containing liquid-crystalline polymers by post functionalization.

PubMed

Yu, Haifeng; Kobayashi, Takaomi; Ge, Ziyi

2009-10-19

A series of functionalized liquid-crystalline polymer materials with different degrees of functionality was synthesized by a post Sonogashira cross-coupling reaction of a polymer precursor. The post-functionalization was carried out under mild conditions and showed a high yield. Although a highly birefringent azotolane group was introduced into the polymer precursor, the photoresponse of the functionalized liquid-crystalline materials was not obviously changed. By adjusting the content of azotolane groups, precise control of the photoinduced birefringence was successfully obtained after thermal enhancement upon annealing. The present method to gain precise control of photoinduced birefringence might enable one to finely photocontrol the optical performances of materials, and may have a potential application as an advanced process for photonic materials. Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Camera-based micro interferometer for distance sensing

NASA Astrophysics Data System (ADS)

Will, Matthias; Schädel, Martin; Ortlepp, Thomas

2017-12-01

Interference of light provides a high precision, non-contact and fast method for measurement method for distances. Therefore this technology dominates in high precision systems. However, in the field of compact sensors capacitive, resistive or inductive methods dominates. The reason is, that the interferometric system has to be precise adjusted and needs a high mechanical stability. As a result, we have usual high-priced complex systems not suitable in the field of compact sensors. To overcome these we developed a new concept for a very small interferometric sensing setup. We combine a miniaturized laser unit, a low cost pixel detector and machine vision routines to realize a demonstrator for a Michelson type micro interferometer. We demonstrate a low cost sensor smaller 1cm3 including all electronics and demonstrate distance sensing up to 30 cm and resolution in nm range.

Precision of measurement and body size in whole-body air-displacement plethysmography.

PubMed

Wells, J C; Fuller, N J

2001-08-01

To investigate methodological and biological precision for air-displacement plethysmography (ADP) across a wide range of body size. Repeated measurements of body volume (BV) and body weight (WT), and derived estimates of density (BD) and indices of fat mass (FM) and fat-free mass (FFM). Sixteen men, aged 22--48 y; 12 women, aged 24--42 y; 13 boys, aged 5--14 y; 17 girls, aged 5--16 y. BV and WT were measured using the Bodpod ADP system from which estimates of BD, FM and FFM were derived. FM and FFM were further adjusted for height to give fat mass index (FMI) and fat-free mass index (FFMI). ADP is very precise for measuring both BV and BD (between 0.16 and 0.44% of the mean). After removing two outliers from the database, and converting BD to body composition, precision of FMI was <6% in adults and within 8% in children, while precision of FFMI was within 1.5% for both age groups. ADP shows good precision for BV and BD across a wide range of body size, subject to biological artefacts. If aberrant values can be identified and rejected, precision of body composition is also good. Aberrant values can be identified by using pairs of ADP procedures, allowing the rejection of data where successive BD values differed by >0.007 kg/l. Precision of FMI obtained using pairs of procedures improves to <4.5% in adults and <5.5% in children.

Adaptive optics and interferometry

NASA Technical Reports Server (NTRS)

Beichman, Charles A.; Ridgway, Stephen

1991-01-01

Adaptive optics and interferometry, two techniques that will improve the limiting resolution of optical and infrared observations by factors of tens or even thousands, are discussed. The real-time adjustment of optical surfaces to compensate for wavefront distortions will improve image quality and increase sensitivity. The phased operation of multiple telescopes separated by large distances will make it possible to achieve very high angular resolution and precise positional measurements. Infrared and optical interferometers that will manipulate light beams and measure interference directly are considered. Angular resolutions of single telescopes will be limited to around 10 milliarcseconds even using the adaptive optics techniques. Interferometry would surpass this limit by a factor of 100 or more. Future telescope arrays with 100-m baselines (resolution of 2.5 milliarcseconds at a 1-micron wavelength) are also discussed.

Dynamic analysis for mental sweating of a group of eccrin sweat glands on a human fingertip by optical coherence tomography

NASA Astrophysics Data System (ADS)

Ohmi, Masato; Tanigawa, Motomu; Wada, Yuki; Haruna, Masamitsu

2011-05-01

OCT is highly potential for in vivo observation of human sweating dynamics which affects activity of the sympathetic nerve. In this paper, we demonstrate dynamic OCT analysis of mental sweating of a group of eccrin sweat glands. The sweating dynamics is tracked simultaneously for nineteen sweat glands by time-sequential piled-up en-face OCT images with the frame spacing of 3.3 sec. Strong non-uniformity is observed in mental sweating where the amount of excess sweat is different for each sweat gland although the sweat glands are adjacent to each other. The non-uniformity should be necessary to adjust as precisely the total amount of excess sweat as possible through the sympathetic nerve in response to strength of the stress.

Digital Droplet PCR: CNV Analysis and Other Applications.

PubMed

Mazaika, Erica; Homsy, Jason

2014-07-14

Digital droplet PCR (ddPCR) is an assay that combines state-of-the-art microfluidics technology with TaqMan-based PCR to achieve precise target DNA quantification at high levels of sensitivity and specificity. Because quantification is achieved without the need for standard assays in an easy to interpret, unambiguous digital readout, ddPCR is far simpler, faster, and less error prone than real-time qPCR. The basic protocol can be modified with minor adjustments to suit a wide range of applications, such as CNV analysis, rare variant detection, SNP genotyping, and transcript quantification. This unit describes the ddPCR workflow in detail for the Bio-Rad QX100 system, but the theory and data interpretation are generalizable to any ddPCR system. Copyright © 2014 John Wiley & Sons, Inc.

Low frequency noise fiber delay stabilized laser with reduced sensitivity to acceleration

NASA Astrophysics Data System (ADS)

Argence, B.; Clivati, C.; Dournaux, J.-L.; Holleville, D.; Faure, B.; Lemonde, P.; Santarelli, G.

2017-11-01

Lasers with sub-hertz line-width and fractional frequency instability around 1×10-15 for 0.1 s to 10 s averaging time are currently realized by locking onto an ultra-stable Fabry-Perot cavity using the Pound-Drever-Hall method. This powerful method requires tight alignment of free space optical components, precise polarization adjustment and spatial mode matching. To circumvent these issues, we use an all-fiber Michelson interferometer with a long fiber spool as a frequency reference and a heterodyne detection technique with a fibered acousto optical modulator (AOM)1. At low Fourier frequencies, the frequency noise of our system is mainly limited by mechanical vibrations, an issue that has already been explored in the field of optoelectronic oscillators.2,3,4

[Evaluation of pipetting systems. III. Micropipette precision in a routine task].

PubMed

Salas, R; Loría, A; Rocha, C

1995-01-01

To establish a norm of the precision achievable with a micropipette in an IRMA assay under routine conditions. A micropipette (Gilson) adjusted to dispense 100 microL was used by a single analyst with experience in its use. In each assay, ten aliquots of radioactive antiprolactin were pipetted in clean tubes (PRE-batch tubes), followed by pipetting of the tubes being processed in the assay, and at the end, a second pipetting of 10 aliquots in clean tubes (POST-batch tubes). The study includes the data of 15 consecutive batches during a seven month period with an overall mean of 283 tubes per batch. The PRE- and POST-tubes were read in a gamma counter (Crystal plus). The mean, SD and CV for PRE, POST and global (PRE+POST) tubes were calculated for each batch. The global CV of the 15 batches ranged from 1.6 to 6.9%, mean of 3.1%. We found no evidence of increased imprecision due to fatigue of the analyst, but surprisingly, we observed that in nine of the 15 batches there was a significant difference in the means of the PRE-tubes vs the POST-tubes (t test) without differences in precision. Thus, part of the global variability is due to what we have called pseudoimprecision (i.e. an increase in CV due to differences in means). In addition, the POST-tubes had higher values in the first 7 batches but the opposite occurred in the last 8 batches (table 2). This shift in the sign of the PRE-POST differences suggests the presence of opposite factors operating in time, i.e. one or more factors increased the volume of pipetting after using the pipette more than 150 times (batches 1-7) whereas other/others decreased it (batches 8-15). 1. Our first approximation to a norm of micropipetting precision in batches of 200-300 tubes was a CV of 3.1%. 2. This norm was influenced by a problem of pseudoimprecision detected ex-post-facto. 3. Our findings justify continuation studies to detect the pseudoimprecision and evaluate its causes prospectively.

Method and apparatus for setting precise nozzle/belt and nozzle/edge dam block gaps

DOEpatents

Carmichael, Robert J.; Dykes, Charles D.; Woodrow, Ronald

1989-05-16

A pair of guide pins are mounted on sideplate extensions of the caster and mating roller pairs are mounted on the nozzle assembly. The nozzle is advanced toward the caster so that the roller pairs engage the guide pins. Both guide pins are remotely adjustable in the vertical direction by hydraulic cylinders acting through eccentrics. This moves the nozzle vertically. The guide pin on the inboard side of the caster is similarly horizontally adjustable. The nozzle roller pair which engage the inboard guide pin are flanged so that the nozzle moves horizontally with the inboard guide pin.

Feedforward and Feedback Motor Control Abnormalities Implicate Cerebellar Dysfunctions in Autism Spectrum Disorder

PubMed Central

Mohanty, Suman; Greene, Rachel K.; Cook, Edwin H.; Vaillancourt, David E.; Sweeney, John A.

2015-01-01

Sensorimotor abnormalities are common in autism spectrum disorder (ASD) and among the earliest manifestations of the disorder. They have been studied far less than the social-communication and cognitive deficits that define ASD, but a mechanistic understanding of sensorimotor abnormalities in ASD may provide key insights into the neural underpinnings of the disorder. In this human study, we examined rapid, precision grip force contractions to determine whether feedforward mechanisms supporting initial motor output before sensory feedback can be processed are disrupted in ASD. Sustained force contractions also were examined to determine whether reactive adjustments to ongoing motor behavior based on visual feedback are altered. Sustained force was studied across multiple force levels and visual gains to assess motor and visuomotor mechanisms, respectively. Primary force contractions of individuals with ASD showed greater peak rate of force increases and large transient overshoots. Individuals with ASD also showed increased sustained force variability that scaled with force level and was more severe when visual gain was highly amplified or highly degraded. When sustaining a constant force level, their reactive adjustments were more periodic than controls, and they showed increased reliance on slower feedback mechanisms. Feedforward and feedback mechanism alterations each were associated with more severe social-communication impairments in ASD. These findings implicate anterior cerebellar circuits involved in feedforward motor control and posterior cerebellar circuits involved in transforming visual feedback into precise motor adjustments in ASD. PMID:25653359

Nano- and micro-structuring of fused silica using time-delay adjustable double flash ns-laser radiation

NASA Astrophysics Data System (ADS)

Lorenz, Pierre; Zhao, Xiongtao; Ehrhardt, Martin; Zagoranskiy, Igor; Zimmer, Klaus; Han, Bing

2018-02-01

Large area, high speed, nanopatterning of surfaces by laser ablation is challenging due to the required high accuracy of the optical and mechanical systems fulfilling the precision of nanopatterning process. Utilization of self-organization approaches can provide an alternative decoupling spot precision and field of machining. The laser-induced front side etching (LIFE) and laser-induced back side dry etching (LIBDE) of fused silica were studied using single and double flash nanosecond laser pulses with a wavelength of 532 nm where the time delay Δτ of the double flash laser pulses was adjusted from 50 ns to 10 μs. The fused silica can be etched at both processes assisted by a 10 nm chromium layer where the etching depth Δz at single flash laser pulses is linear to the laser fluence and independent on the number of laser pulses, from 2 to 12 J/cm2, it is Δz = δLIFE/LIBDE . Φ with δLIFE 16 nm/(J/cm2) and δLIBDE 5.2 nm/(J/cm2) 3 . δLIFE. At double flash laser pulses, the Δz is dependent on the time delay Δτ of the laser pulses and the Δz slightly increased at decreasing Δτ. Furthermore, the surface nanostructuring of fused silica using IPSM-LIFE (LIFE using in-situ pre-structured metal layer) method with a single double flash laser pulse was tested. The first pulse of the double flash results in a melting of the metal layer. The surface tension of the liquid metal layer tends in a droplet formation process and dewetting process, respectively. If the liquid phase life time ΔtLF is smaller than the droplet formation time the metal can be "frozen" in an intermediated state like metal bare structures. The second laser treatment results in a evaporation of the metal and in a partial evaporation and melting of the fused silica surface, where the resultant structures in the fused silica surface are dependent on the lateral geometry of the pre-structured metal layer. A successful IPSM-LIFE structuring could be achieved assisted by a 20 nm molybdenum layer at Δτ >= 174 ns. That path the way for the high speed ultra-fast nanostructuring of dielectric surfaces by self-organizing processes. The different surface structures were analyzed by scanning electron microscopy (SEM) and white light interferometry (WLI).

Department of Defense Precise Time and Time Interval program improvement plan

NASA Technical Reports Server (NTRS)

Bowser, J. R.

1981-01-01

The United States Naval Observatory is responsible for ensuring uniformity in precise time and time interval operations including measurements, the establishment of overall DOD requirements for time and time interval, and the accomplishment of objectives requiring precise time and time interval with minimum cost. An overview of the objectives, the approach to the problem, the schedule, and a status report, including significant findings relative to organizational relationships, current directives, principal PTTI users, and future requirements as currently identified by the users are presented.

Development Roadmap for an Adjustable X-Ray Optics Observatory

NASA Technical Reports Server (NTRS)

Schwartz, Dan; Brissenden, R.; Bookbinder, J.; Davis, W.; Forman, W.; Freeman, M.; O'Dell, S.; Ramsey, B.; Reid, P.; Romaine, S.;

Unification of height systems in the frame of GGOS

NASA Astrophysics Data System (ADS)

Sánchez, Laura

2015-04-01

Most of the existing vertical reference systems do not fulfil the accuracy requirements of modern Geodesy. They refer to local sea surface levels, are stationary (do not consider variations in time), realize different physical height types (orthometric, normal, normal-orthometric, etc.), and their combination in a global frame presents uncertainties at the metre level. To provide a precise geodetic infrastructure for monitoring the Earth system, the Global Geodetic Observing System (GGOS) of the International Association of Geodesy (IAG), promotes the standardization of the height systems worldwide. The main purpose is to establish a global gravity field-related vertical reference system that (1) supports a highly-precise (at cm-level) combination of physical and geometric heights worldwide, (2) allows the unification of all existing local height datums, and (3) guarantees vertical coordinates with global consistency (the same accuracy everywhere) and long-term stability (the same order of accuracy at any time). Under this umbrella, the present contribution concentrates on the definition and realization of a conventional global vertical reference system; the standardization of the geodetic data referring to the existing height systems; and the formulation of appropriate strategies for the precise transformation of the local height datums into the global vertical reference system. The proposed vertical reference system is based on two components: a geometric component consisting of ellipsoidal heights as coordinates and a level ellipsoid as the reference surface, and a physical component comprising geopotential numbers as coordinates and an equipotential surface defined by a conventional W0 value as the reference surface. The definition of the physical component is based on potential parameters in order to provide reference to any type of physical heights (normal, orthometric, etc.). The conversion of geopotential numbers into metric heights and the modelling of the reference surface (geoid or quasigeoid determination) are considered as steps of the realization. The vertical datum unification strategy is based on (1) the physical connection of height datums to determine their discrepancies, (2) joint analysis of satellite altimetry and tide gauge records to determine time variations of sea level at reference tide gauges, (3) combination of geometrical and physical heights in a well-distributed and high-precise reference frame to estimate the relationship between the individual vertical levels and the global one, and (4) analysis of GNSS time series at reference tide gauges to separate crustal movements from sea level changes. The final vertical transformation parameters are provided by the common adjustment of the observation equations derived from these methods.

Error analysis of high-rate GNSS precise point positioning for seismic wave measurement

NASA Astrophysics Data System (ADS)

Shu, Yuanming; Shi, Yun; Xu, Peiliang; Niu, Xiaoji; Liu, Jingnan

2017-06-01

High-rate GNSS precise point positioning (PPP) has been playing a more and more important role in providing precise positioning information in fast time-varying environments. Although kinematic PPP is commonly known to have a precision of a few centimeters, the precision of high-rate PPP within a short period of time has been reported recently with experiments to reach a few millimeters in the horizontal components and sub-centimeters in the vertical component to measure seismic motion, which is several times better than the conventional kinematic PPP practice. To fully understand the mechanism of mystified excellent performance of high-rate PPP within a short period of time, we have carried out a theoretical error analysis of PPP and conducted the corresponding simulations within a short period of time. The theoretical analysis has clearly indicated that the high-rate PPP errors consist of two types: the residual systematic errors at the starting epoch, which affect high-rate PPP through the change of satellite geometry, and the time-varying systematic errors between the starting epoch and the current epoch. Both the theoretical error analysis and simulated results are fully consistent with and thus have unambiguously confirmed the reported high precision of high-rate PPP, which has been further affirmed here by the real data experiments, indicating that high-rate PPP can indeed achieve the millimeter level of precision in the horizontal components and the sub-centimeter level of precision in the vertical component to measure motion within a short period of time. The simulation results have clearly shown that the random noise of carrier phases and higher order ionospheric errors are two major factors to affect the precision of high-rate PPP within a short period of time. The experiments with real data have also indicated that the precision of PPP solutions can degrade to the cm level in both the horizontal and vertical components, if the geometry of satellites is rather poor with a large DOP value.

Gauge Adjusted Global Satellite Mapping of Precipitation (GSMAP_GAUGE)

NASA Astrophysics Data System (ADS)

Mega, T.; Ushio, T.; Yoshida, S.; Kawasaki, Z.; Kubota, T.; Kachi, M.; Aonashi, K.; Shige, S.

2013-12-01

Precipitation is one of the most important parameters on the earth system, and the global distribution of precipitation and its change are essential data for modeling the water cycle, maintaining the ecosystem environment, agricultural production, improvements of the weather forecast precision, flood warning and so on. The GPM (Global Precipitation Measurement) project is led mainly by the United States and Japan, and is now being actively promoted in Europe, France, India, and China with international cooperation. In this project, the microwave radiometers observing microwave emission from rain will be placed on many low-orbit satellites, to reduce the interval to about 3 hours in observation time for each location on the earth. However, the problem of sampling error arises if the global precipitation estimates are less than three hours. Therefore, it is necessary to utilize a gap-filling technique to generate precipitation maps with high temporal resolution, which is quite important for operational uses such as flash flood warning systems. Global Satellite Mapping of Precipitation (GSMaP) project was established by the Japan Science and Technology Agency (JST) in 2002 to produce global precipitation products with high resolution and high precision from not only microwave radiometers but also geostationary infrared radiometers. Currently, the GSMaP_MVK product has been successfully producing fairly good pictures in near real time, and the products shows a comparable score compared with other high-resolution precipitation systems (Ushio et al. 2009 and Kubota et al. 2009). However some evaluations particularly of the operational applications show the tendency of underestimation compared to some ground based observations for the cases showing extremely high precipitation rates. This is partly because the spatial and temporal samplings of the satellite estimates are different from that of the ground based estimates. The microwave imager observes signals from precipitation instantaneously, while the ground based rain gauges collects precipitation particles for one hour at a certain point. This discrepancy can cause the mismatch between the two estimates, and we need to fill the gap of the precipitation estimates between the satellite and rain gauge attributable to the spatial and temporal resolution difference. To that end, the gauge adjusted product named as GSMaP_Gauge has been developed. In this product, the CPC global gauge data analysis by Xie et al. (2007) and Chen et al. (2008) is used for the adjustment of the GSMaP_MVK data. In this presentation, the algorithm concept, examples of the product, and some validation results are presented.

Slow-Release Fertilizers For Plants

NASA Technical Reports Server (NTRS)

Ming, Douglas W.; Golden, D. C.

1995-01-01

Synthetic mineral provides growing plants with nutrients, including micronutrients. Dissolves slowly in moist soil or in hydroponic solution, releasing constituents. Mineral synthetic apatite into which nutrients calcium, phosphorous, iron, manganese, copper, zinc, molybdenum, chlorine, boron, and sulfur incorporated in form of various salts. Each pellet has homogeneous inorganic composition. Composition readily adjusted to meet precise needs of plant.

[Research and application of microcontroller system for target controlled infusion].

PubMed

Cheng, Yuke; Dou, Jianhong; Zhang, Xingan; Wang, Ruosong

2005-08-01

This paper presents a microcontroller system for target controlled infusion according to pharmacodynamic parameters of intravenous anesthetics. It can control the depth of anesthesia by adjusting the level of plasma concentrations. The system has the advantages of high precision, extending power and easy manipulation. It has been used in the clinical anesthesia.

Pumping Insulin during Exercise: What Healthcare Providers and Diabetic Patients Need To Know.

ERIC Educational Resources Information Center

Colberg, Sheri R.; Walsh, John

2002-01-01

Exercise can decrease insulin resistance. Insulin pumps deliver precise insulin adjustments that improve fuel availability and provide glycemic control to help people with diabetes overcome obstacles to exercise. Physicians, patients, and healthcare providers should be familiar with the features and nuances of specific pump models and follow basic…

A new theory of gravity

NASA Technical Reports Server (NTRS)

Ni, W.

1972-01-01

A new relativistic theory of gravity is presented. This theory agrees with all experiments to date. It is a metric theory, it is Lagrangian-based, and it possesses a preferred frame with conformally-flat space slices. With an appropriate choice of certain adjustable functions and parameters, this theory possesses precisely the same post-Newtonian limit as general relativity.

The 26th Annual Precise Time and Time Interval (PTTI) Applications and Planning Meeting

NASA Technical Reports Server (NTRS)

Sydnor, Richard (Editor)

1995-01-01

This document is a compilation of technical papers presented at the 26th Annual PTTI Applications and Planning Meeting. Papers are in the following categories: (1) Recent developments in rubidium, cesium, and hydrogen-based frequency standards, and in cryogenic and trapped-ion technology; (2) International and transnational applications of Precise Time and Time Interval technology with emphasis on satellite laser tracking, GLONASS timing, intercomparison of national time scales and international telecommunications; (3) Applications of Precise Time and Time Interval technology to the telecommunications, power distribution, platform positioning, and geophysical survey industries; (4) Applications of PTTI technology to evolving military communications and navigation systems; and (5) Dissemination of precise time and frequency by means of GPS, GLONASS, MILSTAR, LORAN, and synchronous communications satellites.

Dynamical Coordination of Hand Intrinsic Muscles for Precision Grip in Diabetes Mellitus.

PubMed

Li, Ke; Wei, Na; Cheng, Mei; Hou, Xingguo; Song, Jun

2018-03-12

This study investigated the effects of diabetes mellitus (DM) on dynamical coordination of hand intrinsic muscles during precision grip. Precision grip was tested using a custom designed apparatus with stable and unstable loads, during which the surface electromyographic (sEMG) signals of the abductor pollicis brevis (APB) and first dorsal interosseous (FDI) were recorded simultaneously. Recurrence quantification analysis (RQA) was applied to quantify the dynamical structure of sEMG signals of the APB and FDI; and cross recurrence quantification analysis (CRQA) was used to assess the intermuscular coupling between the two intrinsic muscles. This study revealed that the DM altered the dynamical structure of muscle activation for the FDI and the dynamical intermuscular coordination between the APB and FDI during precision grip. A reinforced feedforward mechanism that compensates the loss of sensory feedbacks in DM may be responsible for the stronger intermuscular coupling between the APB and FDI muscles. Sensory deficits in DM remarkably decreased the capacity of online motor adjustment based on sensory feedback, rendering a lower adaptability to the uncertainty of environment. This study shed light on inherent dynamical properties underlying the intrinsic muscle activation and intermuscular coordination for precision grip and the effects of DM on hand sensorimotor function.

Study on Fuzzy Adaptive Fractional Order PIλDμ Control for Maglev Guiding System

NASA Astrophysics Data System (ADS)

Hu, Qing; Hu, Yuwei

The mathematical model of the linear elevator maglev guiding system is analyzed in this paper. For the linear elevator needs strong stability and robustness to run, the integer order PID was expanded to the fractional order, in order to improve the steady state precision, rapidity and robustness of the system, enhance the accuracy of the parameter in fractional order PIλDμ controller, the fuzzy control is combined with the fractional order PIλDμ control, using the fuzzy logic achieves the parameters online adjustment. The simulations reveal that the system has faster response speed, higher tracking precision, and has stronger robustness to the disturbance.

Control system and method for a power delivery system having a continuously variable ratio transmission

DOEpatents

Frank, Andrew A.

1984-01-01

A control system and method for a power delivery system, such as in an automotive vehicle, having an engine coupled to a continuously variable ratio transmission (CVT). Totally independent control of engine and transmission enable the engine to precisely follow a desired operating characteristic, such as the ideal operating line for minimum fuel consumption. CVT ratio is controlled as a function of commanded power or torque and measured load, while engine fuel requirements (e.g., throttle position) are strictly a function of measured engine speed. Fuel requirements are therefore precisely adjusted in accordance with the ideal characteristic for any load placed on the engine.

Science 101: How Do Atomic Clocks Work?

ERIC Educational Resources Information Center

Science and Children, 2008

2008-01-01

You might be wondering why in the world we need such precise measures of time. Well, many systems we use everyday, such as Global Positioning Systems, require precise synchronization of time. This comes into play in telecommunications and wireless communications, also. For purely scientific reasons, we can use precise measurement of time to…

Time Delay Embedding Increases Estimation Precision of Models of Intraindividual Variability

ERIC Educational Resources Information Center

von Oertzen, Timo; Boker, Steven M.

2010-01-01

This paper investigates the precision of parameters estimated from local samples of time dependent functions. We find that "time delay embedding," i.e., structuring data prior to analysis by constructing a data matrix of overlapping samples, increases the precision of parameter estimates and in turn statistical power compared to standard…

Evaluation of the occlusal contact of crowns fabricated with the bite impression method.

PubMed

Makino, Sachi; Okada, Daizo; Shin, Chiharu; Ogura, Reiko; Ikeda, Masaomi; Miura, Hiroyuki

2013-09-30

In prosthodontic treatment, reconstruction of a proper occlusal contact relationship is very important as well as reconstruction of a proper interproximal relationship and marginal fitness. Unfortunately, occlusal relationships are sometimes lost in the process of occlusal adjustment of crowns. The purpose of this study was to compare the occlusal contacts of single crown fabricated by two different types of impression techniques. Nine subjects, whose molars required treatment with crown restoration, were enrolled in this study. Full cast crowns were fabricated using two types of impression techniques: the conventional impression method (CIM) and the bite impression method (BIM). The occlusal contacts of crowns were precisely evaluated at the following stages: after occlusal adjustment on the articulator (Step 0), before occlusal adjustment in the mouth (Step 1), after occlusal adjustment at the intercuspal position (Step 2), and after occlusal adjustment during lateral and protrusive excursions (Step 3). The number of occlusal contacts of the crowns on the functional cusps fabricated with BIM was significantly greater than that with CIM after occlusal adjustment. For this reason, the crowns fabricated with BIM might have a more functionally desirable occlusal surface compared to the crowns fabricated with CIM.

Molecular interfaces for plasmonic hot electron photovoltaics

NASA Astrophysics Data System (ADS)

Pelayo García de Arquer, F.; Mihi, Agustín; Konstantatos, Gerasimos

2015-01-01

The use of self-assembled monolayers (SAMs) to improve and tailor the photovoltaic performance of plasmonic hot-electron Schottky solar cells is presented. SAMs allow the simultaneous control of open-circuit voltage, hot-electron injection and short-circuit current. To that end, a plurality of molecule structural parameters can be adjusted: SAM molecule's length can be adjusted to control plasmonic hot electron injection. Modifying SAMs dipole moment allows for a precise tuning of the open-circuit voltage. The functionalization of the SAM can also be selected to modify short-circuit current. This allows the simultaneous achievement of high open-circuit voltages (0.56 V) and fill-factors (0.58), IPCE above 5% at the plasmon resonance and maximum power-conversion efficiencies of 0.11%, record for this class of devices.The use of self-assembled monolayers (SAMs) to improve and tailor the photovoltaic performance of plasmonic hot-electron Schottky solar cells is presented. SAMs allow the simultaneous control of open-circuit voltage, hot-electron injection and short-circuit current. To that end, a plurality of molecule structural parameters can be adjusted: SAM molecule's length can be adjusted to control plasmonic hot electron injection. Modifying SAMs dipole moment allows for a precise tuning of the open-circuit voltage. The functionalization of the SAM can also be selected to modify short-circuit current. This allows the simultaneous achievement of high open-circuit voltages (0.56 V) and fill-factors (0.58), IPCE above 5% at the plasmon resonance and maximum power-conversion efficiencies of 0.11%, record for this class of devices. Electronic supplementary information (ESI) available: Contact-potential differentiometry measurements, FTIR characterization, performance statistics and gold devices. See DOI: 10.1039/c4nr06356b

Performance Evaluation of Real-Time Precise Point Positioning Method

NASA Astrophysics Data System (ADS)

Alcay, Salih; Turgut, Muzeyyen

2017-12-01

Post-Processed Precise Point Positioning (PPP) is a well-known zero-difference positioning method which provides accurate and precise results. After the experimental tests, IGS Real Time Service (RTS) officially provided real time orbit and clock products for the GNSS community that allows real-time (RT) PPP applications. Different software packages can be used for RT-PPP. In this study, in order to evaluate the performance of RT-PPP, 3 IGS stations are used. Results, obtained by using BKG Ntrip Client (BNC) Software v2.12, are examined in terms of both accuracy and precision.

Shape adjustment optimization and experiment of cable-membrane reflectors

NASA Astrophysics Data System (ADS)

Du, Jingli; Gu, Yongzhen; Bao, Hong; Wang, Congsi; Chen, Xiaofeng

2018-05-01

Cable-membrane structures are widely employed for large space reflectors due to their lightweight, compact and easy package. In these structures, membranes are attached to cable net, serving as reflectors themselves or as supporting structures for other reflective surface. The cable length and membrane shape have to be carefully designed and fabricated to guarantee the desired reflector surface shape. However, due to inevitable error in cable length and membrane shape during the manufacture and assembly of cable-membrane reflectors, some cables have to be designed to be capable of length adjustment. By carefully adjusting the length of these cables, the degeneration in reflector shape precision due to this inevitable error can be effectively reduced. In the paper a shape adjustment algorithm for cable-membrane reflectors is proposed. Meanwhile, model updating is employed during shape adjustment to decrease the discrepancy of the numerical model with respect to the actual reflector. This discrepancy has to be considered because during attaching membranes to cable net, the accuracy of the membrane shape is hard to guarantee. Numerical examples and experimental results demonstrate the proposed method.

Design of motion adjusting system for space camera based on ultrasonic motor

NASA Astrophysics Data System (ADS)

Xu, Kai; Jin, Guang; Gu, Song; Yan, Yong; Sun, Zhiyuan

2011-08-01

Drift angle is a transverse intersection angle of vector of image motion of the space camera. Adjusting the angle could reduce the influence on image quality. Ultrasonic motor (USM) is a new type of actuator using ultrasonic wave stimulated by piezoelectric ceramics. They have many advantages in comparison with conventional electromagnetic motors. In this paper, some improvement was designed for control system of drift adjusting mechanism. Based on ultrasonic motor T-60 was designed the drift adjusting system, which is composed of the drift adjusting mechanical frame, the ultrasonic motor, the driver of Ultrasonic Motor, the photoelectric encoder and the drift adjusting controller. The TMS320F28335 DSP was adopted as the calculation and control processor, photoelectric encoder was used as sensor of position closed loop system and the voltage driving circuit designed as generator of ultrasonic wave. It was built the mathematic model of drive circuit of the ultrasonic motor T-60 using matlab modules. In order to verify the validity of the drift adjusting system, was introduced the source of the disturbance, and made simulation analysis. It designed the control systems of motor drive for drift adjusting system with the improved PID control. The drift angle adjusting system has such advantages as the small space, simple configuration, high position control precision, fine repeatability, self locking property and low powers. It showed that the system could accomplish the mission of drift angle adjusting excellent.

Stability-indicating method for simultaneous estimation of olmesartan medoxomile, amlodipine besylate and hydrochlorothiazide by RP-HPLC in tablet dosage form.

PubMed

Jain, P S; Patel, M K; Gorle, A P; Chaudhari, A J; Surana, S J

2012-09-01

A simple, specific, accurate and precise stability-indicating reversed-phase high-performance liquid chromatographic method was developed for simultaneous estimation of olmesartan medoxomile (OLME), amlodipine besylate (AMLO) and hydrochlorothiazide (HCTZ) in tablet dosage form. The method was developed using an RP C18 base deactivated silica column (250 × 4.6 mm, 5 µm) with a mobile phase consisting of triethylamine (pH 3.0) adjusted with orthophosphoric acid (A) and acetonitrile (B), with a timed gradient program of T/%B: 0/30, 7/70, 8/30, 10/30 with a flow rate of 1.4 mL/min. Ultraviolet detection was used at 236 nm. The retention times for OLME, AMLO and HCTZ were found to be 6.72, 4.28 and 2.30, respectively. The proposed method was validated for precision, accuracy, linearity, range, robustness, ruggedness and force degradation study. The calibration curves of OLME, AMLO and HCTZ were linear over the range of 50-150, 12.5-37.5 and 31-93 µg/mL, respectively. The method was found to be sensitive. The limits of detection of OLME, AMLO and HCTZ were determined 0.19, 0.16 and 0.22 µg/mL and limits of quantification of OLME, AMLO and HCTZ were determined 0.57, 0.49 and 0.66, respectively. Forced degradation study was performed according to International Conference on Harmonization guidelines.

Influence of Waveform Characteristics on LiDAR Ranging Accuracy and Precision

PubMed Central

Yang, Bingwei; Xie, Xinhao; Li, Duan

2018-01-01

Time of flight (TOF) based light detection and ranging (LiDAR) is a technology for calculating distance between start/stop signals of time of flight. In lab-built LiDAR, two ranging systems for measuring flying time between start/stop signals include time-to-digital converter (TDC) that counts time between trigger signals and analog-to-digital converter (ADC) that processes the sampled start/stop pulses waveform for time estimation. We study the influence of waveform characteristics on range accuracy and precision of two kinds of ranging system. Comparing waveform based ranging (WR) with analog discrete return system based ranging (AR), a peak detection method (WR-PK) shows the best ranging performance because of less execution time, high ranging accuracy, and stable precision. Based on a novel statistic mathematical method maximal information coefficient (MIC), WR-PK precision has a high linear relationship with the received pulse width standard deviation. Thus keeping the received pulse width of measuring a constant distance as stable as possible can improve ranging precision. PMID:29642639

Development of a screening method for genetically modified soybean by plasmid-based quantitative competitive polymerase chain reaction.

PubMed

Shimizu, Eri; Kato, Hisashi; Nakagawa, Yuki; Kodama, Takashi; Futo, Satoshi; Minegishi, Yasutaka; Watanabe, Takahiro; Akiyama, Hiroshi; Teshima, Reiko; Furui, Satoshi; Hino, Akihiro; Kitta, Kazumi

2008-07-23

A novel type of quantitative competitive polymerase chain reaction (QC-PCR) system for the detection and quantification of the Roundup Ready soybean (RRS) was developed. This system was designed based on the advantage of a fully validated real-time PCR method used for the quantification of RRS in Japan. A plasmid was constructed as a competitor plasmid for the detection and quantification of genetically modified soy, RRS. The plasmid contained the construct-specific sequence of RRS and the taxon-specific sequence of lectin1 (Le1), and both had 21 bp oligonucleotide insertion in the sequences. The plasmid DNA was used as a reference molecule instead of ground seeds, which enabled us to precisely and stably adjust the copy number of targets. The present study demonstrated that the novel plasmid-based QC-PCR method could be a simple and feasible alternative to the real-time PCR method used for the quantification of genetically modified organism contents.

A Wearable and Highly Sensitive Graphene Strain Sensor for Precise Home-Based Pulse Wave Monitoring.

PubMed

Yang, Tingting; Jiang, Xin; Zhong, Yujia; Zhao, Xuanliang; Lin, Shuyuan; Li, Jing; Li, Xinming; Xu, Jianlong; Li, Zhihong; Zhu, Hongwei

2017-07-28

Profuse medical information about cardiovascular properties can be gathered from pulse waveforms. Therefore, it is desirable to design a smart pulse monitoring device to achieve noninvasive and real-time acquisition of cardiovascular parameters. The majority of current pulse sensors are usually bulky or insufficient in sensitivity. In this work, a graphene-based skin-like sensor is explored for pulse wave sensing with features of easy use and wearing comfort. Moreover, the adjustment of the substrate stiffness and interfacial bonding accomplish the optimal balance between sensor linearity and signal sensitivity, as well as measurement of the beat-to-beat radial arterial pulse. Compared with the existing bulky and nonportable clinical instruments, this highly sensitive and soft sensing patch not only provides primary sensor interface to human skin, but also can objectively and accurately detect the subtle pulse signal variations in a real-time fashion, such as pulse waveforms with different ages, pre- and post-exercise, thus presenting a promising solution to home-based pulse monitoring.

Blood-Based Analyses of Cancer: Circulating Tumor Cells and Circulating Tumor DNA

PubMed Central

Haber, Daniel A.; Velculescu, Victor E.

2015-01-01

The ability to study nonhematologic cancers through noninvasive sampling of blood is one of the most exciting and rapidly advancing fields in cancer diagnostics. This has been driven both by major technologic advances, including the isolation of intact cancer cells and the analysis of cancer cell–derived DNA from blood samples, and by the increasing application of molecularly driven therapeutics, which rely on such accurate and timely measurements of critical biomarkers. Moreover, the dramatic efficacy of these potent cancer therapies drives the selection for additional genetic changes as tumors acquire drug resistance, necessitating repeated sampling of cancer cells to adjust therapy in response to tumor evolution. Together, these advanced noninvasive diagnostic capabilities and their applications in guiding precision cancer therapies are poised to change the ways in which we select and monitor cancer treatments. Significance Recent advances in technologies to analyze circulating tumor cells and circulating tumor DNA are setting the stage for real-time, noninvasive monitoring of cancer and providing novel insights into cancer evolution, invasion, and metastasis. PMID:24801577

Active laser ranging with frequency transfer using frequency comb

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Hongyuan; Wei, Haoyun; Yang, Honglei

2016-05-02

A comb-based active laser ranging scheme is proposed for enhanced distance resolution and a common time standard for the entire system. Three frequency combs with different repetition rates are used as light sources at the two ends where the distance is measured. Pulse positions are determined through asynchronous optical sampling and type II second harmonic generation. Results show that the system achieves a maximum residual of 379.6 nm and a standard deviation of 92.9 nm with 2000 averages over 23.6 m. Moreover, as for the frequency transfer, an atom clock and an adjustable signal generator, synchronized to the atom clock, are used asmore » time standards for the two ends to appraise the frequency deviation introduced by the proposed system. The system achieves a residual fractional deviation of 1.3 × 10{sup −16} for 1 s, allowing precise frequency transfer between the two clocks at the two ends.« less

Residential instability and obesity over time: the role of the social and built environment.

PubMed

Jones, Antwan

2015-03-01

This research uses the National Longitudinal Study of Adult Health's Obesity and Neighborhood Environment (ONE) to examine the relationship between residential instability and change in obesity in the United States. Mobility is thought to be related to obesity because it conditions what kinds of amenities are present in the areas where people live and what level of motivation individuals have to take advantage of these amenities. Thus, this research uses spatial measures as potential confounders for the mobility-health relationship. Results suggest that mobility is a protective factor against weight gain over time. However, the effect of mobility is completely explained by the environmental characteristics. After adjusting for changes in physical activity resources and the crime rate, adolescents who move and adolescents who do not move have precisely the same risk of being obese. Mobility is thus a function of the change in environmental characteristics. Implications for developing the built environment are discussed. Copyright © 2015 Elsevier Ltd. All rights reserved.

A ground track control algorithm for the Topographic Mapping Laser Altimeter (TMLA)

NASA Technical Reports Server (NTRS)

Blaes, V.; Mcintosh, R.; Roszman, L.; Cooley, J.

1993-01-01

The results of an analysis of an algorithm that will provide autonomous onboard orbit control using orbits determined with Global Positioning System (GPS) data. The algorithm uses the GPS data to (1) compute the ground track error relative to a fixed longitude grid, and (2) determine the altitude adjustment required to correct the longitude error. A program was written on a personal computer (PC) to test the concept for numerous altitudes and values of solar flux using a simplified orbit model including only the J sub 2 zonal harmonic and simple orbit decay computations. The algorithm was then implemented in a precision orbit propagation program having a full range of perturbations. The analysis showed that, even with all perturbations (including actual time histories of solar flux variation), the algorithm could effectively control the spacecraft ground track and yield more than 99 percent Earth coverage in the time required to complete one coverage cycle on the fixed grid (220 to 230 days depending on altitude and overlap allowance).

Nitrogen plasma-treated multilayer graphene-based field effect transistor fabrication and electronic characteristics

NASA Astrophysics Data System (ADS)

Su, Wei-Jhih; Chang, Hsuan-Chen; Honda, Shin-ichi; Lin, Pao-Hung; Huang, Ying-Sheng; Lee, Kuei-Yi

2017-08-01

Chemical doping with hetero-atoms is an effective method used to change the characteristics of materials. Nitrogen doping technology plays a critical role in regulating the electronic properties of graphene. Nitrogen plasma treatment was used in this work to dope nitrogen atoms to modulate multilayer graphene electrical properties. The measured I-V multilayer graphene-base field-effect transistor characteristics (GFETs) showed a V-shaped transfer curve with the hole and electron region separated from the measured current-voltage (I-V) minimum. GFETs fabricated with multilayer graphene from chemical vapor deposition (CVD) exhibited p-type behavior because of oxygen adsorption. After using different nitrogen plasma treatment times, the minimum in I-V characteristic shifted into the negative gate voltage region with increased nitrogen concentration and the GFET channel became an n-type semiconductor. GFETs could be easily fabricated using this method with potential for various applications. The GFET transfer characteristics could be tuned precisely by adjusting the nitrogen plasma treatment time.

Validation of a HPLC method for determination of hydroxymethylfurfural in crude palm oil.

PubMed

Ariffin, Abdul Azis; Ghazali, H M; Kavousi, Parviz

2014-07-01

For the first time 5-hydroxymethyl-2-furaldehyde (HMF) was separated from crude palm oil (CPO), and its authenticity was determined using an RP-HPLC method. Separation was accomplished with isocratic elution of a mobile phase comprising water and methanol (92:8 v/v) on a Purospher Star RP-18e column (250mm×4.6mm, 5.0μm). The flow rate was adjusted to 1ml/min and detection was performed at 284nm. The method was validated, and results obtained exhibit a good recovery (95.58% to 98.39%). Assessment of precision showed that the relative standard deviations (RSD%) of retention times and peak areas of spiked samples were less than 0.59% and 2.66%, respectively. Further, the limit of detection (LOD) and LOQ were 0.02, 0.05mg/kg, respectively, and the response was linear across the applied ranges. The crude palm oil samples analysed exhibited HMF content less than 2.27mg/kg. Copyright © 2014 Elsevier Ltd. All rights reserved.

Active vibration control of a single-stage spur gearbox

NASA Astrophysics Data System (ADS)

Dogruer, C. U.; Pirsoltan, Abbas K.

2017-02-01

The dynamic transmission error between driving and driven gears of a gear mechanism with torsional mode is induced by periodic time-varying mesh stiffness. In this study, to minimize the adverse effect of this time-varying mesh stiffness, a nonlinear controller which adjusts the torque acting on the driving gear is proposed. The basic approach is to modulate the input torque such that it compensates the periodic change in mesh stiffness. It is assumed that gears are assembled with high precision and gearbox is analyzed by a finite element software to calculate the mesh stiffness curve. Thus, change in the mesh stiffness, which is inherently nonlinear, can be predicted and canceled by a feed-forward loop. Then, remaining linear dynamics is controlled by pole placement techniques. Under these premises, it is claimed that any acceleration and velocity profile of the input shaft can be tracked accurately. Thereby, dynamic transmission error is kept to a minimum possible value and a spur gearbox, which does not emit much noise and vibration, is designed.

UTC Time Transfer for High Frequency Trading Using IS-95 CDMA Base Station Transmissions and IEEE-1588 Precision Time Protocol

DTIC Science & Technology

2010-11-01

CDMA base stations are each synchronized by GPS receivers, they provide an indirect link to GPS system time and UTC time . The major stock...antenna synchronizes the Local Area Network (LAN) to within 10 microseconds of UTC using the IEEE-1588 Precision Time Protocol (PTP). This is an...activities. Understanding and measuring latency on the LAN is key to the success of HFTs. Without precise time synchronization below 1 millisecond

Gradated assembly of multiple proteins into supramolecular nanomaterials

NASA Astrophysics Data System (ADS)

Hudalla, Gregory A.; Sun, Tao; Gasiorowski, Joshua Z.; Han, Huifang; Tian, Ye F.; Chong, Anita S.; Collier, Joel H.

2014-08-01

Biomaterials exhibiting precise ratios of different bioactive protein components are critical for applications ranging from vaccines to regenerative medicine, but their design is often hindered by limited choices and cross-reactivity of protein conjugation chemistries. Here, we describe a strategy for inducing multiple different expressed proteins of choice to assemble into nanofibres and gels with exceptional compositional control. The strategy employs ‘βTail’ tags, which allow for good protein expression in bacteriological cultures, yet can be induced to co-assemble into nanomaterials when mixed with additional β-sheet fibrillizing peptides. Multiple different βTail fusion proteins could be inserted into peptide nanofibres alone or in combination at predictable, smoothly gradated concentrations, providing a simple yet versatile route to install precise combinations of proteins into nanomaterials. The technology is illustrated by achieving precisely targeted hues using mixtures of fluorescent proteins, by creating nanofibres bearing enzymatic activity, and by adjusting antigenic dominance in vaccines.

Trending and accuracy of noninvasive hemoglobin monitoring in pediatric perioperative patients.

PubMed

Patino, Mario; Schultz, Lindsay; Hossain, Monir; Moeller, Jennifer; Mahmoud, Mohamed; Gunter, Joel; Kurth, C Dean

2014-10-01

Rainbow Pulse CO-Oximetry technology (Masimo Corporation, Irvine, CA) provides continuous and noninvasive measurement of arterial hemoglobin concentration (SpHb). We assessed the trending and accuracy of SpHb by this innovative monitoring compared with Hb concentration obtained with conventional laboratory techniques (Hb) in children undergoing surgical procedures with potential for substantial blood loss. Hb concentrations were recorded from Pulse CO-Oximetry and a conventional hematology analyzer. Regression analysis and 4-quadrant plot were used to evaluate the trending for changes in SpHb and Hb measurements (ΔSpHb and ΔHb). Bias, precision, and limits of agreement of SpHb and of in vivo adjusted SpHb (SpHb - first bias to HB) compared with Hb were calculated. One hundred fifty-eight SpHb-Hb data pairs and 105 delta pairs (ΔSpHb and ΔHb) from 46 patients aged 2 months to 17 years with Hb ranging from 16.7 to 7.9 g/dL were collected. To evaluate trending, the delta pairs (ΔSpHb and ΔHb) were plotted, which revealed a positive correlation (ΔSpHb = 0.022 + 0.76ΔHb) with correlation coefficient r = 0.76, 95% CI [confidence interval] = 0.57-0.86. The bias and precision of SpHb to Hb and in vivo adjusted SpHb were 0.4 ± 1.3 g/dL and 0.1 ± 1.2 g/dL, respectively; the limits of agreement were -2.0 to 3.2 g/dL before in vivo adjustment and -2.4 to 2.2 g/dL after in vivo adjustment (P value = 0.04). The mean percent bias (from the reference Hb concentration) decreased from 4.1% ± 11.9% to 0.7% ± 11.3% (P value = 0.01). No drift in bias over time was observed during the study procedure. Of patient demographic and physiological factors tested for correlation with the SpHb, only perfusion index at sensor site showed a weak correlation. The accuracy of SpHb in children with normal Hb and mild anemia is similar to that previously reported in adults and is independent of patient demographic and physiological states except for a weak correlation with perfusion index. The trending of SpHb and Hb in children with normal Hb and mild anemia showed a positive correlation. Further studies are necessary in children with moderate and severe anemia.

[Development and evaluation of a novel three-dimensional adjustable confocal laser-induced fluorescence detector].

PubMed

Liu, Fan; Yu, Shuxin; Tang, Tao; Sun, Yuanshe; Zhang, Weibing; Li, Tong

2011-09-01

Laser-induced fluorescence detector (LIFD) is one of the most sensitive detectors in analytical chemical files. Confocal optical configuration is widely used in LIFDs. Two effective approaches used to achieve the best signal to noise ratio (S/N) are increasing the confocal precision and minimizing the background noise. A novel three-dimensional adjustable confocal LIFD was developed, using a new three-dimensional adjustable supporter of reflector and modularized optical system. A detection limit (S/N = 3) of 1 x 10(-12) mol/L and a linear dynamic range of 3 orders of magnitude were obtained using fluorescein isothiocyanate (FITC) standard as the test sample. The noise level and drift levels were 8.0 x 10(-3) mV and 1.4 x 10(-3) mV/h, respectively, which were almost 10 times lower than before. And the stability of the LIFD was evaluated by five replicate injections of 5 x 10(-9) mol/L FITC, and the relative standard deviations (RSDs) of peak height and peak area were 0.38% and 0.41%, respectively. Further more, three biogenic amines, which were derivatized by FITC, were separated by high performance liquid chromatography (HPLC) and then detected by the novel LIFD. And the detection limits (S/N = 3) ranged 0.01 to 0.02 nmol/L, which were better than other methods. Therefore, the LIFD is highly sensitive, as well as shows a real low noise level and good reproducibility.

Effect of high altitude on blood glucose meter performance.

PubMed

Fink, Kenneth S; Christensen, Dale B; Ellsworth, Allan

2002-01-01

Participation in high-altitude wilderness activities may expose persons to extreme environmental conditions, and for those with diabetes mellitus, euglycemia is important to ensure safe travel. We conducted a field assessment of the precision and accuracy of seven commonly used blood glucose meters while mountaineering on Mount Rainier, located in Washington State (elevation 14,410 ft). At various elevations each climber-subject used the randomly assigned device to measure the glucose level of capillary blood and three different concentrations of standardized control solutions, and a venous sample was also collected for later glucose analysis. Ordinary least squares regression was used to assess the effect of elevation and of other environmental potential covariates on the precision and accuracy of blood glucose meters. Elevation affects glucometer precision (p = 0.08), but becomes less significant (p = 0.21) when adjusted for temperature and relative humidity. The overall effect of elevation was to underestimate glucose levels by approximately 1-2% (unadjusted) for each 1,000 ft gain in elevation. Blood glucose meter accuracy was affected by elevation (p = 0.03), temperature (p < 0.01), and relative humidity (p = 0.04) after adjustment for the other variables. The interaction between elevation and relative humidity had a meaningful but not statistically significant effect on accuracy (p = 0.07). Thus, elevation, temperature, and relative humidity affect blood glucose meter performance, and elevated glucose levels are more greatly underestimated at higher elevations. Further research will help to identify which blood glucose meters are best suited for specific environments.

A biotin-triggered genetic switch in mammalian cells and mice.

PubMed

Weber, Wilfried; Lienhart, Cédric; Baba, Marie Daoud-El; Fussenegger, Martin

2009-03-01

Adjustable and reversible transgene expression systems enabling precise control of metabolic pathways and tunable production of specific target proteins have been essential for conditional reprogramming of mammalian cells to achieve progress in basic and applied bioengineering disciplines. Most of the currently available transgene control modalities have been designed to be responsive to clinically licensed pharmacologically active drugs which were expected to prevail in future clinical trials yet raised concerns about side effects when administered long term at subclinical doses. We have chosen vitamin H, also known as biotin, to control target gene transcription in mammalian cells in a potentially side effect-free manner. BirA, the Escherichia coli repressor of the biotin biosynthesis operon, was fused to the Herpes simplex transactivation domain to generate a biotin-dependent transactivator(BIT), which, in the presence of biotin, binds and activates chimeric target promoters (P(BIT)) harboring BirA-specific operator sites 5' of a minimal promoter. Biotin-inducible transgene expression was functional in a variety of rodent, monkey and human cell lines, showed excellent adjustability and reversibility in transgenic Chinese hamster ovary cell lines, provided precise product gene control in standard bioreactor cultures and enabled dose-dependent vitamin H control of a human glycoprotein in mice. The combination of a side effect-free inducer, precise and reversible transcription tunability and broad functionality in different cell types as well as in entire animals represents a unique asset for the use of biotin-inducible transgene control in future gene therapy, tissue engineering and biopharmaceutical manufacturing scenarios.

A hybrid double-observer sightability model for aerial surveys

USGS Publications Warehouse

Griffin, Paul C.; Lubow, Bruce C.; Jenkins, Kurt J.; Vales, David J.; Moeller, Barbara J.; Reid, Mason; Happe, Patricia J.; Mccorquodale, Scott M.; Tirhi, Michelle J.; Schaberi, Jim P.; Beirne, Katherine

2013-01-01

Raw counts from aerial surveys make no correction for undetected animals and provide no estimate of precision with which to judge the utility of the counts. Sightability modeling and double-observer (DO) modeling are 2 commonly used approaches to account for detection bias and to estimate precision in aerial surveys. We developed a hybrid DO sightability model (model MH) that uses the strength of each approach to overcome the weakness in the other, for aerial surveys of elk (Cervus elaphus). The hybrid approach uses detection patterns of 2 independent observer pairs in a helicopter and telemetry-based detections of collared elk groups. Candidate MH models reflected hypotheses about effects of recorded covariates and unmodeled heterogeneity on the separate front-seat observer pair and back-seat observer pair detection probabilities. Group size and concealing vegetation cover strongly influenced detection probabilities. The pilot's previous experience participating in aerial surveys influenced detection by the front pair of observers if the elk group was on the pilot's side of the helicopter flight path. In 9 surveys in Mount Rainier National Park, the raw number of elk counted was approximately 80–93% of the abundance estimated by model MH. Uncorrected ratios of bulls per 100 cows generally were low compared to estimates adjusted for detection bias, but ratios of calves per 100 cows were comparable whether based on raw survey counts or adjusted estimates. The hybrid method was an improvement over commonly used alternatives, with improved precision compared to sightability modeling and reduced bias compared to DO modeling.

The 22nd Annual Precise Time and Time Interval (PTTI) Applications and Planning Meeting

NASA Technical Reports Server (NTRS)

Sydnor, Richard L. (Editor)

1990-01-01

Papers presented at the 22nd Annual Precise Time and Time Interval (PTTI) Applications and Planning Meeting are compiled. The following subject areas are covered: Rb, Cs, and H-based frequency standards and cryogenic and trapped-ion technology; satellite laser tracking networks, GLONASS timing, intercomparison of national time scales and international telecommunications; telecommunications, power distribution, platform positioning, and geophysical survey industries; military communications and navigation systems; and dissemination of precise time and frequency by means of GPS, GLONASS, MILSTAR, LORAN, and synchronous communication satellites.

Submillihertz magnetic spectroscopy performed with a nanoscale quantum sensor

NASA Astrophysics Data System (ADS)

Schmitt, Simon; Gefen, Tuvia; Stürner, Felix M.; Unden, Thomas; Wolff, Gerhard; Müller, Christoph; Scheuer, Jochen; Naydenov, Boris; Markham, Matthew; Pezzagna, Sebastien; Meijer, Jan; Schwarz, Ilai; Plenio, Martin; Retzker, Alex; McGuinness, Liam P.; Jelezko, Fedor

2017-05-01

Precise timekeeping is critical to metrology, forming the basis by which standards of time, length, and fundamental constants are determined. Stable clocks are particularly valuable in spectroscopy because they define the ultimate frequency precision that can be reached. In quantum metrology, the qubit coherence time defines the clock stability, from which the spectral linewidth and frequency precision are determined. We demonstrate a quantum sensing protocol in which the spectral precision goes beyond the sensor coherence time and is limited by the stability of a classical clock. Using this technique, we observed a precision in frequency estimation scaling in time T as T-3/2 for classical oscillating fields. The narrow linewidth magnetometer based on single spins in diamond is used to sense nanoscale magnetic fields with an intrinsic frequency resolution of 607 microhertz, which is eight orders of magnitude narrower than the qubit coherence time.

Adjusting measured peak discharges from an urbanizing watershed to reflect a stationary land use signal

NASA Astrophysics Data System (ADS)

Beighley, R. Edward; Moglen, Glenn E.

2003-04-01

A procedure to adjust gauged streamflow data from watersheds urbanized during or after their gauging period is presented. The procedure adjusts streamflow to be representative of a fixed land use condition, which may reflect current or future development conditions. Our intent is to determine what an event resulting in a peak discharge in, for example, 1950 (i.e., before urbanization) would produce on the current urban watershed. While past approaches assumed uniform spatial and temporal changes in urbanization, this study focuses on the use of geographic information systems (GIS) based methodologies for precisely locating in space and time where land use change has occurred. This information is incorporated into a hydrologic model to simulate the change in discharge as a result of changing land use conditions. In this paper, we use historical aerial photographs, GIS linked tax-map data, and recent land use/land cover data to recreate the spatial development history of eight gauged watersheds in the Baltimore-Washington, D. C., metropolitan area. Using our procedure to determine discharge series representative of the current urban watersheds, we found that the increase of the adjusted 2-year discharge ranged from 16 to 70 percent compared with the measured annual maximum discharge series. For the 100-year discharge the adjusted values ranged from 0 to 47 percent greater than the measured values. Additionally, relationships between the increase in flood flows and four measures of urbanization (increase in urban land, decrease in forested land, increase in high-density development, and the spatial development pattern) are investigated for predicting the increase in flood flows for ungauged watersheds. Watersheds with the largest increases in flood flows typically had more extensive development in the areas far removed from the outlet. In contrast, watersheds with development located nearer to the outlet typically had the smallest increases in peak discharge.

Anogenital distance: A longitudinal evaluation of its variants and indices in boys and girls of Sonora, Mexico.

PubMed

Loreto-Gómez, Carmen; Farías, Paulina; Moreno-Macías, Hortensia; Romano-Riquer, S P; Riojas-Rodríguez, Horacio

2017-10-01

There is no consensus on which anogenital distance (AGD) variant to use and how to adjust it by body size in humans. This study quantitatively evaluated AGD variants and body size adjustments to determine which would be the best choice. AGD variants, height, and weight were measured on five occasions during the first year of life of 307 infants. The ratio of anoscrotal distance (ASD) in boys and anofourchette distance (AFD) in girls increased from 1.9 at birth to 2.3 at 12 months of age. Each AGD variant was divided by each body size variable to generate different indices. Such indices were standardized to make them comparable when analyzing their performance through mixed models. ASD and AFD adjusted by height generated precise (p<0.05) AGD indices: 0.4-0.5 and 0.2, respectively. Results suggest that the best body size adjustment for all AGD variants in the first year of life is height. Copyright © 2017 Elsevier Inc. All rights reserved.

Speeding up the Consensus Clustering methodology for microarray data analysis

PubMed Central

2011-01-01

Background The inference of the number of clusters in a dataset, a fundamental problem in Statistics, Data Analysis and Classification, is usually addressed via internal validation measures. The stated problem is quite difficult, in particular for microarrays, since the inferred prediction must be sensible enough to capture the inherent biological structure in a dataset, e.g., functionally related genes. Despite the rich literature present in that area, the identification of an internal validation measure that is both fast and precise has proved to be elusive. In order to partially fill this gap, we propose a speed-up of Consensus (Consensus Clustering), a methodology whose purpose is the provision of a prediction of the number of clusters in a dataset, together with a dissimilarity matrix (the consensus matrix) that can be used by clustering algorithms. As detailed in the remainder of the paper, Consensus is a natural candidate for a speed-up. Results Since the time-precision performance of Consensus depends on two parameters, our first task is to show that a simple adjustment of the parameters is not enough to obtain a good precision-time trade-off. Our second task is to provide a fast approximation algorithm for Consensus. That is, the closely related algorithm FC (Fast Consensus) that would have the same precision as Consensus with a substantially better time performance. The performance of FC has been assessed via extensive experiments on twelve benchmark datasets that summarize key features of microarray applications, such as cancer studies, gene expression with up and down patterns, and a full spectrum of dimensionality up to over a thousand. Based on their outcome, compared with previous benchmarking results available in the literature, FC turns out to be among the fastest internal validation methods, while retaining the same outstanding precision of Consensus. Moreover, it also provides a consensus matrix that can be used as a dissimilarity matrix, guaranteeing the same performance as the corresponding matrix produced by Consensus. We have also experimented with the use of Consensus and FC in conjunction with NMF (Nonnegative Matrix Factorization), in order to identify the correct number of clusters in a dataset. Although NMF is an increasingly popular technique for biological data mining, our results are somewhat disappointing and complement quite well the state of the art about NMF, shedding further light on its merits and limitations. Conclusions In summary, FC with a parameter setting that makes it robust with respect to small and medium-sized datasets, i.e, number of items to cluster in the hundreds and number of conditions up to a thousand, seems to be the internal validation measure of choice. Moreover, the technique we have developed here can be used in other contexts, in particular for the speed-up of stability-based validation measures. PMID:21235792

Global Velocities from VLBI

NASA Technical Reports Server (NTRS)

Ma, Chopo; Gordon, David; MacMillan, Daniel

1999-01-01

Precise geodetic Very Long Baseline Interferometry (VLBI) measurements have been made since 1979 at about 130 points on all major tectonic plates, including stable interiors and deformation zones. From the data set of about 2900 observing sessions and about 2.3 million observations, useful three-dimensional velocities can be derived for about 80 sites using an incremental least-squares adjustment of terrestrial, celestial, Earth rotation and site/session-specific parameters. The long history and high precision of the data yield formal errors for horizontal velocity as low as 0.1 mm/yr, but the limitation on the interpretation of individual site velocities is the tie to the terrestrial reference frame. Our studies indicate that the effect of converting precise relative VLBI velocities to individual site velocities is an error floor of about 0.4 mm/yr. Most VLBI horizontal velocities in stable plate interiors agree with the NUVEL-1A model, but there are significant departures in Africa and the Pacific. Vertical precision is worse by a factor of 2-3, and there are significant non-zero values that can be interpreted as post-glacial rebound, regional effects, and local disturbances.

Mirror with thermally controlled radius of curvature

DOEpatents

Neil, George R.; Shinn, Michelle D.

2010-06-22

A radius of curvature controlled mirror for controlling precisely the focal point of a laser beam or other light beam. The radius of curvature controlled mirror provides nearly spherical distortion of the mirror in response to differential expansion between the front and rear surfaces of the mirror. The radius of curvature controlled mirror compensates for changes in other optical components due to heating or other physical changes. The radius of curvature controlled mirror includes an arrangement for adjusting the temperature of the front surface and separately adjusting the temperature of the rear surface to control the radius of curvature. The temperature adjustment arrangements can include cooling channels within the mirror body or convection of a gas upon the surface of the mirror. A control system controls the differential expansion between the front and rear surfaces to achieve the desired radius of curvature.

75 FR 38988 - Notice of Petitions by Firms for Determination of Eligibility To Apply for Trade Adjustment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-07

... Manufacturing Company, 65 Tripps Lane, East, 6/10/2010 Fulford Manufacturing company manufactures Inc. RI 02915... decrease in sales or production of each petitioning firm. List of Petitions Received by EDA for... Products for filing Flinchbaugh Engineering, Inc... 4387 Run Way, York, PA 6/7/2010 Precision manufacturing...

75 FR 30068 - Notice of Determinations Regarding Eligibility To Apply for Worker Adjustment Assistance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-28

..., Austin, TX: October 19, 2008 TA-W-72,981: TEVA Pharmaceuticals, IVAX Division, Congers, NY: November 20... Semiconductor, Inc., Microcontroller Solutions Group (MSG), Austin, TX: December 9, 2008 TA-W-73,200: Sabre...., A Subsidiary of Precision Dynamics Corporation, Dallas, TX: February 1, 2009 TA-W-73,463: Work-Fit...

[The research on a pocket microcontroller system for target controlled infusion].

PubMed

Cheng, Yu-Ke; Zhang, Xin-An; Zhang, Yan-Wu; Wu, Qun-Ling; Dou, Jian-Hong; Wang, Rou-Shong

2005-05-01

This paper present a microcontroller system for target controlled infusion according to pharmacodynamic parameters of intravenous anesthetics. It can control the depth of anesthesia by adjusting the level of plasma concentrations. The system has the advantages of high precision, extended function and easy operation. It has been now used in the clinical anesthesia.

Bias and Precision of Measures of Association for a Fixed-Effect Multivariate Analysis of Variance Model

ERIC Educational Resources Information Center

Kim, Soyoung; Olejnik, Stephen

2005-01-01

The sampling distributions of five popular measures of association with and without two bias adjusting methods were examined for the single factor fixed-effects multivariate analysis of variance model. The number of groups, sample sizes, number of outcomes, and the strength of association were manipulated. The results indicate that all five…

Accurate Determination of the Values of Fundamental Physical Constants: The Basis of the New "Quantum" SI Units

NASA Astrophysics Data System (ADS)

Karshenboim, S. G.

2018-03-01

The metric system appeared as the system of units designed for macroscopic (laboratory scale) measurements. The progress in accurate determination of the values of quantum constants (such as the Planck constant) in SI units shows that the capabilities in high-precision measurement of microscopic and macroscopic quantities in terms of the same units have increased substantially recently. At the same time, relative microscopic measurements (for example, the comparison of atomic transition frequencies or atomic masses) are often much more accurate than relative measurements of macroscopic quantities. This is the basis for the strategy to define units in microscopic phenomena and then use them on the laboratory scale, which plays a crucial role in practical methodological applications determined by everyday life and technologies. The international CODATA task group on fundamental constants regularly performs an overall analysis of the precision world data (the so-called Adjustment of the Fundamental Constants) and publishes their recommended values. The most recent evaluation was based on the data published by the end of 2014; here, we review the corresponding data and results. The accuracy in determination of the Boltzmann constant has increased, the consistency of the data on determination of the Planck constant has improved; it is these two dimensional constants that will be used in near future as the basis for the new definition of the kelvin and kilogram, respectively. The contradictions in determination of the Rydberg constant and the proton charge radius remain. The accuracy of determination of the fine structure constant and relative atomic weight of the electron has improved. Overall, we give a detailed review of the state of the art in precision determination of the values of fundamental constants. The mathematical procedure of the Adjustment, the new data and results are considered in detail. The limitations due to macroscopic properties of material standards (such as the International prototype of the kilogram) and the isotopic composition of substances involved in precision studies in general (as standard measures for the triple point of water) and, in particular, in the determination of the fundamental constants are discussed. The perspectives of the introduction of the new quantum units, which will be free from the mentioned problems, are considered. Many physicists feel no sympathy for the International system of units (SI), believing that it does not properly reflect the character of physical laws. In fact, there are three parallel systems, namely the systems of quantities, system of their units and the related standards. The definition of the units, in particular, the SI units, above all, reflects our ability to perform precision measurements of physical values under certain conditions, in particular, to create appropriate standards. This requirement is not related to the beauty of fundamental laws of nature. More accurate determination of the fundamental constants is one of the areas where we accumulate such experience.

Crop Yield Predictions - High Resolution Statistical Model for Intra-season Forecasts Applied to Corn in the US

NASA Astrophysics Data System (ADS)

Cai, Y.

2017-12-01

Accurately forecasting crop yields has broad implications for economic trading, food production monitoring, and global food security. However, the variation of environmental variables presents challenges to model yields accurately, especially when the lack of highly accurate measurements creates difficulties in creating models that can succeed across space and time. In 2016, we developed a sequence of machine-learning based models forecasting end-of-season corn yields for the US at both the county and national levels. We combined machine learning algorithms in a hierarchical way, and used an understanding of physiological processes in temporal feature selection, to achieve high precision in our intra-season forecasts, including in very anomalous seasons. During the live run, we predicted the national corn yield within 1.40% of the final USDA number as early as August. In the backtesting of the 2000-2015 period, our model predicts national yield within 2.69% of the actual yield on average already by mid-August. At the county level, our model predicts 77% of the variation in final yield using data through the beginning of August and improves to 80% by the beginning of October, with the percentage of counties predicted within 10% of the average yield increasing from 68% to 73%. Further, the lowest errors are in the most significant producing regions, resulting in very high precision national-level forecasts. In addition, we identify the changes of important variables throughout the season, specifically early-season land surface temperature, and mid-season land surface temperature and vegetation index. For the 2017 season, we feed 2016 data to the training set, together with additional geospatial data sources, aiming to make the current model even more precise. We will show how our 2017 US corn yield forecasts converges in time, which factors affect the yield the most, as well as present our plans for 2018 model adjustments.

Vertical interferometer workstation for testing large spherical optics

NASA Astrophysics Data System (ADS)

Truax, B.

2013-09-01

The design of an interferometer workstation for the testing of large concave and convex spherical optics is presented. The workstation handles optical components and mounts up to 425 mm in diameter with mass of up to 40 kg with 6 axes of adjustment. A unique method for the implementation of focus, roll and pitch was used allowing for extremely precise adjustment. The completed system includes transmission spheres with f-numbers from f/1.6 to f/0.82 incorporating reference surface diameters of up to 306 mm and surface accuracies of better than 63 nm PVr. The design challenges and resulting solutions are discussed. System performance results are presented.

Precision alignment device

DOEpatents

Jones, N.E.

1988-03-10

Apparatus for providing automatic alignment of beam devices having an associated structure for directing, collimating, focusing, reflecting, or otherwise modifying the main beam. A reference laser is attached to the structure enclosing the main beam producing apparatus and produces a reference beam substantially parallel to the main beam. Detector modules containing optical switching devices and optical detectors are positioned in the path of the reference beam and are effective to produce an electrical output indicative of the alignment of the main beam. This electrical output drives servomotor operated adjustment screws to adjust the position of elements of the structure associated with the main beam to maintain alignment of the main beam. 5 figs.

The Mechanical Design of a Kinematic Mount for the Mid Infrared Instrument Focal Plane Module on the James Webb Space Telescope

NASA Technical Reports Server (NTRS)

Thelen, Michael P.; Moore, Donald M.

2009-01-01

The detector assembly for the Mid Infrared Instrument (MIRI) of the James Webb Space Telescope (JWST) is mechanically supported in the Focal Plane Module (FPM) Assembly with an efficient hexapod design. The kinematic mount design allows for precision adjustment of the detector boresight to assembly alignment fiducials and maintains optical alignment requirements during flight conditions of launch and cryogenic operations below 7 Kelvin. This kinematic mounting technique is able to be implemented in a variety of optical-mechanical designs and is capable of micron level adjustment control and stability over wide dynamic and temperature ranges.

Precision alignment device

DOEpatents

Jones, Nelson E.

1990-01-01

Apparatus for providing automatic alignment of beam devices having an associated structure for directing, collimating, focusing, reflecting, or otherwise modifying the main beam. A reference laser is attached to the structure enclosing the main beam producing apparatus and produces a reference beam substantially parallel to the main beam. Detector modules containing optical switching devices and optical detectors are positioned in the path of the reference beam and are effective to produce an electrical output indicative of the alignment of the main beam. This electrical output drives servomotor operated adjustment screws to adjust the position of elements of the structure associated with the main beam to maintain alignment of the main beam.

Application of Least-Squares Adjustment Technique to Geometric Camera Calibration and Photogrammetric Flow Visualization

NASA Technical Reports Server (NTRS)

Chen, Fang-Jenq

1997-01-01

Flow visualization produces data in the form of two-dimensional images. If the optical components of a camera system are perfect, the transformation equations between the two-dimensional image and the three-dimensional object space are linear and easy to solve. However, real camera lenses introduce nonlinear distortions that affect the accuracy of transformation unless proper corrections are applied. An iterative least-squares adjustment algorithm is developed to solve the nonlinear transformation equations incorporated with distortion corrections. Experimental applications demonstrate that a relative precision on the order of 40,000 is achievable without tedious laboratory calibrations of the camera.

High precision pulsar timing and spin frequency second derivatives

NASA Astrophysics Data System (ADS)

Liu, X. J.; Bassa, C. G.; Stappers, B. W.

2018-05-01

We investigate the impact of intrinsic, kinematic and gravitational effects on high precision pulsar timing. We present an analytical derivation and a numerical computation of the impact of these effects on the first and second derivative of the pulsar spin frequency. In addition, in the presence of white noise, we derive an expression to determine the expected measurement uncertainty of a second derivative of the spin frequency for a given timing precision, observing cadence and timing baseline and find that it strongly depends on the latter (∝t-7/2). We show that for pulsars with significant proper motion, the spin frequency second derivative is dominated by a term dependent on the radial velocity of the pulsar. Considering the data sets from three Pulsar Timing Arrays, we find that for PSR J0437-4715 a detectable spin frequency second derivative will be present if the absolute value of the radial velocity exceeds 33 km s-1. Similarly, at the current timing precision and cadence, continued timing observations of PSR J1909-3744 for about another eleven years, will allow the measurement of its frequency second derivative and determine the radial velocity with an accuracy better than 14 km s-1. With the ever increasing timing precision and observing baselines, the impact of the, largely unknown, radial velocities of pulsars on high precision pulsar timing can not be neglected.

Bipolar square-wave current source for transient electromagnetic systems based on constant shutdown time

NASA Astrophysics Data System (ADS)

Wang, Shilong; Yin, Changchun; Lin, Jun; Yang, Yu; Hu, Xueyan

2016-03-01

Cooperative work of multiple magnetic transmitting sources is a new trend in the development of transient electromagnetic system. The key is the bipolar current waves shutdown, concurrently in the inductive load. In the past, it was difficult to use the constant clamping voltage technique to realize the synchronized shutdown of currents with different peak values. Based on clamping voltage technique, we introduce a new controlling method with constant shutdown time. We use the rising time to control shutdown time and use low voltage power source to control peak current. From the viewpoint of the circuit energy loss, by taking the high-voltage capacitor bypass resistance and the capacitor of the passive snubber circuit into account, we establish the relationship between the rising time and the shutdown time. Since the switch is not ideal, we propose a new method to test the shutdown time by the low voltage, the high voltage and the peak current. Experimental results show that adjustment of the current rising time can precisely control the value of the clamp voltage. When the rising time is fixed, the shutdown time is unchanged. The error for shutdown time deduced from the energy consumption is less than 6%. The new controlling method on current shutdown proposed in this paper can be used in the cooperative work of borehole and ground transmitting system.

Bipolar square-wave current source for transient electromagnetic systems based on constant shutdown time.

PubMed

Wang, Shilong; Yin, Changchun; Lin, Jun; Yang, Yu; Hu, Xueyan

2016-03-01

Cooperative work of multiple magnetic transmitting sources is a new trend in the development of transient electromagnetic system. The key is the bipolar current waves shutdown, concurrently in the inductive load. In the past, it was difficult to use the constant clamping voltage technique to realize the synchronized shutdown of currents with different peak values. Based on clamping voltage technique, we introduce a new controlling method with constant shutdown time. We use the rising time to control shutdown time and use low voltage power source to control peak current. From the viewpoint of the circuit energy loss, by taking the high-voltage capacitor bypass resistance and the capacitor of the passive snubber circuit into account, we establish the relationship between the rising time and the shutdown time. Since the switch is not ideal, we propose a new method to test the shutdown time by the low voltage, the high voltage and the peak current. Experimental results show that adjustment of the current rising time can precisely control the value of the clamp voltage. When the rising time is fixed, the shutdown time is unchanged. The error for shutdown time deduced from the energy consumption is less than 6%. The new controlling method on current shutdown proposed in this paper can be used in the cooperative work of borehole and ground transmitting system.

IEEE-1588(Trademark) Standard for a Precision Clock Synchronization Protocol for Networked Measurement and Control Systems

DTIC Science & Technology

2002-12-01

34th Annual Precise Time and Time Interval (PTTI) Meeting 243 IEEE-1588™ STANDARD FOR A PRECISION CLOCK SYNCHRONIZATION PROTOCOL FOR... synchronization . 2. Cyclic-systems. In cyclic-systems, timing is periodic and is usually defined by the characteristics of a cyclic network or bus...incommensurate, timing schedules for each device are easily implemented. In addition, synchronization accuracy depends on the accuracy of the common

Comparative effectiveness of commonly used devices for carotid artery stenting: an NCDR Analysis (National Cardiovascular Data Registry).

PubMed

Giri, Jay; Kennedy, Kevin F; Weinberg, Ido; Hawkins, Beau M; Press, Marcella Calfon; Drachman, Douglas; McCormick, Daniel J; Aronow, Herbert D; White, Christopher J; Rosenfield, Kenneth; Yeh, Robert W

2014-02-01

This study sought to characterize usage and outcomes of carotid stenting platforms. A variety of stents and embolic protection devices (EPDs) are used for carotid artery stenting. Little is known about current usage patterns and differences in outcomes with these devices. We analyzed 12,135 consecutive carotid stent procedures in the NCDR (National Cardiovascular Data Registry) CARE (Carotid Artery Revascularization and Endarterectomy) registry performed between January 1, 2007 and March 31, 2012. We compared baseline characteristics and crude and multivariable-adjusted rates of in-hospital combined death/stroke among patients treated with Acculink/Accunet (Abbott Laboratories, Abbott Park, Illinois), Xact/Emboshield (Abbott), and Precise/Angioguard (Cordis Corporation, Bridgewater, New Jersey) stent/EPD combinations. In 78.2% of cases, stents were used in conjunction with their specific, corresponding U.S. Food and Drug Administration-approved EPD. The Acculink/Accunet (n = 2,617, 21.6%), Xact/Emboshield (n = 3,507, 28.9%), and Precise/Angioguard (n = 2,696, 22.2%) stent/EPD combinations were used in 72.7% of all cases. The Protégé/SpiderFx (ev3 Endovascular Inc., Plymouth, Minnesota) (n = 453, 3.7%) and Wallstent/Filterwire (Boston Scientific, Natick, Massachusetts) (n = 213, 1.8%) devices were used in a minority of cases. In unadjusted analyses, the Precise/Angioguard system was associated with higher rates of the primary outcome than were the Acculink/Accunet (2.5% vs. 1.8%; p = 0.058) and Xact/Emboshield (2.5% vs. 1.9%; p = 0.14) systems that were not statistically different. In adjusted analyses, differences between Precise/Angioguard and Accunet/Acculink (odds ratio [OR]: 1.48, 95% confidence interval [CI]: 0.89 to 2.47; p = 0.065), Precise/Angioguard and Xact/Emboshield (OR: 1.16, 95% CI: 0.77 to 1.76; p = 0.38), and Xact/Emboshield and Accunet/Acculink (OR: 1.28, 95% CI: 0.82 to 1.97; p = 0.18) remained nonsignificant. In modern U.S. practice, the Acculink/Accunet, Xact/Emboshield, and Precise/Angioguard carotid stenting systems are used in most cases and are associated with similarly low rates of adverse events. Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Monitoring Digital Closed-Loop Feedback Systems

NASA Technical Reports Server (NTRS)

Katz, Richard; Kleyner, Igor

2011-01-01

A technique of monitoring digital closed-loop feedback systems has been conceived. The basic idea is to obtain information on the performances of closed-loop feedback circuits in such systems to aid in the determination of the functionality and integrity of the circuits and of performance margins. The need for this technique arises as follows: Some modern digital systems include feedback circuits that enable other circuits to perform with precision and are tolerant of changes in environment and the device s parameters. For example, in a precision timing circuit, it is desirable to make the circuit insensitive to variability as a result of the manufacture of circuit components and to the effects of temperature, voltage, radiation, and aging. However, such a design can also result in masking the indications of damaged and/or deteriorating components. The present technique incorporates test circuitry and associated engineering-telemetry circuitry into an embedded system to monitor the closed-loop feedback circuits, using spare gates that are often available in field programmable gate arrays (FPGAs). This technique enables a test engineer to determine the amount of performance margin in the system, detect out of family circuit performance, and determine one or more trend(s) in the performance of the system. In one system to which the technique has been applied, an ultra-stable oscillator is used as a reference for internal adjustment of 12 time-to-digital converters (TDCs). The feedback circuit produces a pulse-width-modulated signal that is fed as a control input into an amplifier, which controls the circuit s operating voltage. If the circuit s gates are determined to be operating too slowly or rapidly when their timing is compared with that of the reference signal, then the pulse width increases or decreases, respectively, thereby commanding the amplifier to increase or reduce, respectively, its output level, and "adjust" the speed of the circuits. The nominal frequency of the TDC s pulse width modulated outputs is approximately 40 kHz. In this system, the technique is implemented by means of a monitoring circuit that includes a 20-MHz sampling circuit and a 24-bit accumulator with a gate time of 10 ms. The monitoring circuit measures the duty cycle of each of the 12 TDCs at a repetition rate of 28 Hz. The accumulator content is reset to all zeroes at the beginning of each measurement period and is then incremented or decremented based of the value of the state of the pulse width modulated signal. Positive or negative values in the accumulator correspond to duty cycles greater or less, respectively, than 50 percent.

Intraosseous samples can be used for creatinine measurements--an experimental study in the anaesthetised pig.

PubMed

Strandberg, Gunnar; Lipcsey, Miklós; Eriksson, Mats; Larsson, Anders

2014-01-01

Intraosseous (IO) access is a valuable tool in prehospital locations and in emergency departments when other forms of vascular access are unavailable. Creatinine is often used for dose adjustment of drugs that may be administered through intraosseous cannulae. We aimed to study the possibility of analysing creatinine in intraosseous samples and study the accuracy and precision of such measurements. Eight pigs with endotoxin induced septic shock were sampled hourly for six hours and analysed for plasma creatinine. Samples were collected from arterial, venous, and IO cannulae. There was an increase in creatinine values during the later part of the experiment. The coefficients of variation between the three sampling sites were less than 10% at all sampling times. Based on our findings intraosseous samples can be used for creatinine determination in emergency settings.

A Novel High Performance Liquid Chromatographic Method for Simultaneous Determination of Ceftriaxone and Sulbactam in Sulbactomax

PubMed Central

Shrivastava, Sanjay Mohan; Singh, Rajkumar; Tariq, Abu; Siddiqui, Masoom Raza; Yadav, Jitendar; Negi, P. S.; Chaudhary, Manu

2009-01-01

An isocratic liquid chromatographic method with UV detection at 220 nm is described for simultaneous determination of ceftriaxone sodium and sulbactam sodium in Sulbactomax. Chromatographic separation of two drugs was achieved on a Hypersil ODS C-18 column using a mobile phase consisting of a binary mixture of acetonitrile and tetrabutyl ammonium hydroxide adjusted to pH7.0 with orthophosphoric acid in ratio 70:30. The developed Liquid Chromatographic method offers symmetric peak shape, good resolution and reasonable retention time for both drugs. Linearity, accuracy and precision were found to be acceptable over the concentration range of 125-750 ppm for ceftriaxone sodium and 62.5-375 ppm for sulbactam sodium. The LC method can be used for the quality control of formulated products containing ceftriaxone and sulbactam. PMID:23675112

Ultra-short pulse generation in the hybridly mode-locked erbium-doped all-fiber ring laser with a distributed polarizer

NASA Astrophysics Data System (ADS)

Krylov, Alexander A.; Sazonkin, Stanislav G.; Lazarev, Vladimir A.; Dvoretskiy, Dmitriy A.; Leonov, Stanislav O.; Pnev, Alexey B.; Karasik, Valeriy E.; Grebenyukov, Vyacheslav V.; Pozharov, Anatoly S.; Obraztsova, Elena D.; Dianov, Evgeny M.

2015-06-01

We report for the first time to the best of our knowledge on the ultra-short pulse (USP) generation in the dispersion-managed erbium-doped all-fiber ring laser hybridly mode-locked with boron nitride-doped single-walled carbon nanotubes in the co-action with a nonlinear polarization evolution in the ring cavity with a distributed polarizer. Stable 92.6 fs dechirped pulses were obtained via precise polarization state adjustment at a central wavelength of 1560 nm with 11.2 mW average output power, corresponding to the 2.9 kW maximum peak power. We have also observed the laser switching from a USP generation regime to a chirped pulse one with a corresponding pulse-width of 7.1 ps at the same intracavity dispersion.

Basic research and data analysis for the National Geodetic Satellite program and for the Earth Surveys program

NASA Technical Reports Server (NTRS)

1972-01-01

Current research is reported on precise and accurate descriptions of the earth's surface and gravitational field and on time variations of geophysical parameters. A new computer program was written in connection with the adjustment of the BC-4 worldwide geometric satellite triangulation net. The possibility that an increment to accuracy could be transferred from a super-control net to the basic geodetic (first-order triangulation) was investigated. Coordinates of the NA9 solution were computed and were transformed to the NAD datum, based on GEOS 1 observations. Normal equations from observational data of several different systems and constraint equations were added and a single solution was obtained for the combined systems. Transformation parameters with constraints were determined, and the impact of computers on surveying and mapping is discussed.

Calcium signalling indicates bilateral power balancing in the Drosophila flight muscle during manoeuvring flight

PubMed Central

Lehmann, Fritz-Olaf; Skandalis, Dimitri A.; Berthé, Ruben

2013-01-01

Manoeuvring flight in animals requires precise adjustments of mechanical power output produced by the flight musculature. In many insects such as fruit flies, power generation is most likely varied by altering stretch-activated tension, that is set by sarcoplasmic calcium levels. The muscles reside in a thoracic shell that simultaneously drives both wings during wing flapping. Using a genetically expressed muscle calcium indicator, we here demonstrate in vivo the ability of this animal to bilaterally adjust its calcium activation to the mechanical power output required to sustain aerodynamic costs during flight. Motoneuron-specific comparisons of calcium activation during lift modulation and yaw turning behaviour suggest slightly higher calcium activation for dorso-longitudinal than for dorsoventral muscle fibres, which corroborates the elevated need for muscle mechanical power during the wings’ downstroke. During turning flight, calcium activation explains only up to 54 per cent of the required changes in mechanical power, suggesting substantial power transmission between both sides of the thoracic shell. The bilateral control of muscle calcium runs counter to the hypothesis that the thorax of flies acts as a single, equally proportional source for mechanical power production for both flapping wings. Collectively, power balancing highlights the precision with which insects adjust their flight motor to changing energetic requirements during aerial steering. This potentially enhances flight efficiency and is thus of interest for the development of technical vehicles that employ bioinspired strategies of power delivery to flapping wings. PMID:23486171

Feedforward and feedback motor control abnormalities implicate cerebellar dysfunctions in autism spectrum disorder.

PubMed

Mosconi, Matthew W; Mohanty, Suman; Greene, Rachel K; Cook, Edwin H; Vaillancourt, David E; Sweeney, John A

2015-02-04

Sensorimotor abnormalities are common in autism spectrum disorder (ASD) and among the earliest manifestations of the disorder. They have been studied far less than the social-communication and cognitive deficits that define ASD, but a mechanistic understanding of sensorimotor abnormalities in ASD may provide key insights into the neural underpinnings of the disorder. In this human study, we examined rapid, precision grip force contractions to determine whether feedforward mechanisms supporting initial motor output before sensory feedback can be processed are disrupted in ASD. Sustained force contractions also were examined to determine whether reactive adjustments to ongoing motor behavior based on visual feedback are altered. Sustained force was studied across multiple force levels and visual gains to assess motor and visuomotor mechanisms, respectively. Primary force contractions of individuals with ASD showed greater peak rate of force increases and large transient overshoots. Individuals with ASD also showed increased sustained force variability that scaled with force level and was more severe when visual gain was highly amplified or highly degraded. When sustaining a constant force level, their reactive adjustments were more periodic than controls, and they showed increased reliance on slower feedback mechanisms. Feedforward and feedback mechanism alterations each were associated with more severe social-communication impairments in ASD. These findings implicate anterior cerebellar circuits involved in feedforward motor control and posterior cerebellar circuits involved in transforming visual feedback into precise motor adjustments in ASD. Copyright © 2015 the authors 0270-6474/15/352015-11$15.00/0.

Precise color images a high-speed color video camera system with three intensified sensors

NASA Astrophysics Data System (ADS)

Oki, Sachio; Yamakawa, Masafumi; Gohda, Susumu; Etoh, Takeharu G.

1999-06-01

High speed imaging systems have been used in a large field of science and engineering. Although the high speed camera systems have been improved to high performance, most of their applications are only to get high speed motion pictures. However, in some fields of science and technology, it is useful to get some other information, such as temperature of combustion flame, thermal plasma and molten materials. Recent digital high speed video imaging technology should be able to get such information from those objects. For this purpose, we have already developed a high speed video camera system with three-intensified-sensors and cubic prism image splitter. The maximum frame rate is 40,500 pps (picture per second) at 64 X 64 pixels and 4,500 pps at 256 X 256 pixels with 256 (8 bit) intensity resolution for each pixel. The camera system can store more than 1,000 pictures continuously in solid state memory. In order to get the precise color images from this camera system, we need to develop a digital technique, which consists of a computer program and ancillary instruments, to adjust displacement of images taken from two or three image sensors and to calibrate relationship between incident light intensity and corresponding digital output signals. In this paper, the digital technique for pixel-based displacement adjustment are proposed. Although the displacement of the corresponding circle was more than 8 pixels in original image, the displacement was adjusted within 0.2 pixels at most by this method.

Effectiveness of anonymised information sharing and use in health service, police, and local government partnership for preventing violence related injury: experimental study and time series analysis

PubMed Central

Florence, Curtis; Brennan, Iain; Simon, Thomas

2011-01-01

Objective To evaluate the effectiveness of anonymised information sharing to prevent injury related to violence. Design Experimental study and time series analysis of a prototype community partnership between the health service, police, and local government partners designed to prevent violence. Setting Cardiff, Wales, and 14 comparison cities designated “most similar” by the Home Office in England and Wales. Intervention After a 33 month development period, anonymised data relevant to violence prevention (precise violence location, time, days, and weapons) from patients attending emergency departments in Cardiff and reporting injury from violence were shared over 51 months with police and local authority partners and used to target resources for violence prevention. Main outcome measures Health service records of hospital admissions related to violence and police records of woundings and less serious assaults in Cardiff and other cities after adjustment for potential confounders. Results Information sharing and use were associated with a substantial and significant reduction in hospital admissions related to violence. In the intervention city (Cardiff) rates fell from seven to five a month per 100 000 population compared with an increase from five to eight in comparison cities (adjusted incidence rate ratio 0.58, 95% confidence interval 0.49 to 0.69). Average rate of woundings recorded by the police changed from 54 to 82 a month per 100 000 population in Cardiff compared with an increase from 54 to 114 in comparison cities (adjusted incidence rate ratio 0.68, 0.61 to 0.75). There was a significant increase in less serious assaults recorded by the police, from 15 to 20 a month per 100 000 population in Cardiff compared with a decrease from 42 to 33 in comparison cities (adjusted incidence rate ratio 1.38, 1.13 to 1.70). Conclusion An information sharing partnership between health services, police, and local government in Cardiff, Wales, altered policing and other strategies to prevent violence based on information collected from patients treated in emergency departments after injury sustained in violence. This intervention led to a significant reduction in violent injury and was associated with an increase in police recording of minor assaults in Cardiff compared with similar cities in England and Wales where this intervention was not implemented. PMID:21680632

Effectiveness of anonymised information sharing and use in health service, police, and local government partnership for preventing violence related injury: experimental study and time series analysis.

PubMed

Florence, Curtis; Shepherd, Jonathan; Brennan, Iain; Simon, Thomas

2011-06-16

To evaluate the effectiveness of anonymised information sharing to prevent injury related to violence. Experimental study and time series analysis of a prototype community partnership between the health service, police, and local government partners designed to prevent violence. Cardiff, Wales, and 14 comparison cities designated "most similar" by the Home Office in England and Wales. After a 33 month development period, anonymised data relevant to violence prevention (precise violence location, time, days, and weapons) from patients attending emergency departments in Cardiff and reporting injury from violence were shared over 51 months with police and local authority partners and used to target resources for violence prevention. Health service records of hospital admissions related to violence and police records of woundings and less serious assaults in Cardiff and other cities after adjustment for potential confounders. Information sharing and use were associated with a substantial and significant reduction in hospital admissions related to violence. In the intervention city (Cardiff) rates fell from seven to five a month per 100,000 population compared with an increase from five to eight in comparison cities (adjusted incidence rate ratio 0.58, 95% confidence interval 0.49 to 0.69). Average rate of woundings recorded by the police changed from 54 to 82 a month per 100,000 population in Cardiff compared with an increase from 54 to 114 in comparison cities (adjusted incidence rate ratio 0.68, 0.61 to 0.75). There was a significant increase in less serious assaults recorded by the police, from 15 to 20 a month per 100,000 population in Cardiff compared with a decrease from 42 to 33 in comparison cities (adjusted incidence rate ratio 1.38, 1.13 to 1.70). An information sharing partnership between health services, police, and local government in Cardiff, Wales, altered policing and other strategies to prevent violence based on information collected from patients treated in emergency departments after injury sustained in violence. This intervention led to a significant reduction in violent injury and was associated with an increase in police recording of minor assaults in Cardiff compared with similar cities in England and Wales where this intervention was not implemented.

The effect of recovery duration on running speed and stroke quality during intermittent training drills in elite tennis players.

PubMed

Ferrauti, A; Pluim, B M; Weber, K

2001-04-01

The aim of this study was to assess the effect of the recovery duration in intermittent training drills on metabolism and coordination in sport games. Ten nationally ranked male tennis players (age 25.3+/-3.7 years, height 1.83+/-0.8 m, body mass 77.8+/-7.7 kg; mean +/- sx) participated in a passing-shot drill (baseline sprint with subsequent passing shot) that aimed to improve both starting speed and stroke quality (speed and precision). Time pressure for stroke preparation was individually adjusted by a ball-machine and corresponded to 80% of maximum running speed. In two trials (T10, T15) separated by 2 weeks, the players completed 30 strokes and sprints subdivided into 6 x 5 repetitions with a 1 min rest between series. The rest between each stroke-and-sprint lasted either 10 s (T10) or 15 s (T15). The sequence of both conditions was randomized between participants. Post-exercise blood lactate concentration was significantly elevated in T10 (9.04+/-3.06 vs 5.01+/-1.35 mmol x l(-1), P < 0.01). Running time for stroke preparation (1.405+/-0.044 vs 1.376+/-0.045 s, P < 0.05) and stroke speed (106+/-12 vs 114+/-8 km x h(-1), P < 0.05) were significantly decreased in T10, while stroke precision - that is, more target hits (P < 0.1) and fewer errors (P < 0.05) - tended to be higher. We conclude that running speed and stroke quality during intermittent tennis drills are highly dependent on the duration of recovery time. Optimization of training efficacy in sport games (e.g. combined improvement of conditional and technical skills) requires skilful fine-tuning of monitoring guidelines.

Adjustment of the dynamic weight distribution as a sensitive parameter for diagnosis of postural alteration in a rodent model of vestibular deficit

PubMed Central

Tighilet, Brahim; Péricat, David; Frelat, Alais; Cazals, Yves; Rastoldo, Guillaume; Boyer, Florent; Dumas, Olivier

2017-01-01

Vestibular disorders, by inducing significant posturo-locomotor and cognitive disorders, can significantly impair the most basic tasks of everyday life. Their precise diagnosis is essential to implement appropriate therapeutic countermeasures. Monitoring their evolution is also very important to validate or, on the contrary, to adapt the undertaken therapeutic actions. To date, the diagnosis methods of posturo-locomotor impairments are restricted to examinations that most often lack sensitivity and precision. In the present work we studied the alterations of the dynamic weight distribution in a rodent model of sudden and complete unilateral vestibular loss. We used a system of force sensors connected to a data analysis system to quantify in real time and in an automated way the weight bearing of the animal on the ground. We show here that sudden, unilateral, complete and permanent loss of the vestibular inputs causes a severe alteration of the dynamic ground weight distribution of vestibulo lesioned rodents. Characteristics of alterations in the dynamic weight distribution vary over time and follow the sequence of appearance and disappearance of the various symptoms that compose the vestibular syndrome. This study reveals for the first time that dynamic weight bearing is a very sensitive parameter for evaluating posturo-locomotor function impairment. Associated with more classical vestibular examinations, this paradigm can considerably enrich the methods for assessing and monitoring vestibular disorders. Systematic application of this type of evaluation to the dizzy or unstable patient could improve the detection of vestibular deficits and allow predicting better their impact on posture and walk. Thus it could also allow a better follow-up of the therapeutic approaches for rehabilitating gait and balance. PMID:29112981

Two Independent Contributions to Step Variability during Over-Ground Human Walking

PubMed Central

Collins, Steven H.; Kuo, Arthur D.

2013-01-01

Human walking exhibits small variations in both step length and step width, some of which may be related to active balance control. Lateral balance is thought to require integrative sensorimotor control through adjustment of step width rather than length, contributing to greater variability in step width. Here we propose that step length variations are largely explained by the typical human preference for step length to increase with walking speed, which itself normally exhibits some slow and spontaneous fluctuation. In contrast, step width variations should have little relation to speed if they are produced more for lateral balance. As a test, we examined hundreds of overground walking steps by healthy young adults (N = 14, age < 40 yrs.). We found that slow fluctuations in self-selected walking speed (2.3% coefficient of variation) could explain most of the variance in step length (59%, P < 0.01). The residual variability not explained by speed was small (1.5% coefficient of variation), suggesting that step length is actually quite precise if not for the slow speed fluctuations. Step width varied over faster time scales and was independent of speed fluctuations, with variance 4.3 times greater than that for step length (P < 0.01) after accounting for the speed effect. That difference was further magnified by walking with eyes closed, which appears detrimental to control of lateral balance. Humans appear to modulate fore-aft foot placement in precise accordance with slow fluctuations in walking speed, whereas the variability of lateral foot placement appears more closely related to balance. Step variability is separable in both direction and time scale into balance- and speed-related components. The separation of factors not related to balance may reveal which aspects of walking are most critical for the nervous system to control. PMID:24015308

Adjustment of the dynamic weight distribution as a sensitive parameter for diagnosis of postural alteration in a rodent model of vestibular deficit.

PubMed

Tighilet, Brahim; Péricat, David; Frelat, Alais; Cazals, Yves; Rastoldo, Guillaume; Boyer, Florent; Dumas, Olivier; Chabbert, Christian

2017-01-01

Vestibular disorders, by inducing significant posturo-locomotor and cognitive disorders, can significantly impair the most basic tasks of everyday life. Their precise diagnosis is essential to implement appropriate therapeutic countermeasures. Monitoring their evolution is also very important to validate or, on the contrary, to adapt the undertaken therapeutic actions. To date, the diagnosis methods of posturo-locomotor impairments are restricted to examinations that most often lack sensitivity and precision. In the present work we studied the alterations of the dynamic weight distribution in a rodent model of sudden and complete unilateral vestibular loss. We used a system of force sensors connected to a data analysis system to quantify in real time and in an automated way the weight bearing of the animal on the ground. We show here that sudden, unilateral, complete and permanent loss of the vestibular inputs causes a severe alteration of the dynamic ground weight distribution of vestibulo lesioned rodents. Characteristics of alterations in the dynamic weight distribution vary over time and follow the sequence of appearance and disappearance of the various symptoms that compose the vestibular syndrome. This study reveals for the first time that dynamic weight bearing is a very sensitive parameter for evaluating posturo-locomotor function impairment. Associated with more classical vestibular examinations, this paradigm can considerably enrich the methods for assessing and monitoring vestibular disorders. Systematic application of this type of evaluation to the dizzy or unstable patient could improve the detection of vestibular deficits and allow predicting better their impact on posture and walk. Thus it could also allow a better follow-up of the therapeutic approaches for rehabilitating gait and balance.

Semilocal momentum-space regularized chiral two-nucleon potentials up to fifth order

NASA Astrophysics Data System (ADS)

Reinert, P.; Krebs, H.; Epelbaum, E.

2018-05-01

We introduce new semilocal two-nucleon potentials up to fifth order in the chiral expansion. We employ a simple regularization approach for the pion exchange contributions which i) maintains the long-range part of the interaction, ii) is implemented in momentum space and iii) can be straightforwardly applied to regularize many-body forces and current operators. We discuss in detail the two-nucleon contact interactions at fourth order and demonstrate that three terms out of fifteen used in previous calculations can be eliminated via suitably chosen unitary transformations. The removal of the redundant contact terms results in a drastic simplification of the fits to scattering data and leads to interactions which are much softer ( i.e., more perturbative) than our recent semilocal coordinate-space regularized potentials. Using the pion-nucleon low-energy constants from matching pion-nucleon Roy-Steiner equations to chiral perturbation theory, we perform a comprehensive analysis of nucleon-nucleon scattering and the deuteron properties up to fifth chiral order and study the impact of the leading F-wave two-nucleon contact interactions which appear at sixth order. The resulting chiral potentials at fifth order lead to an outstanding description of the proton-proton and neutron-proton scattering data from the self-consistent Granada-2013 database below the pion production threshold, which is significantly better than for any other chiral potential. For the first time, the chiral potentials match in precision and even outperform the available high-precision phenomenological potentials, while the number of adjustable parameters is, at the same time, reduced by about ˜ 40%. Last but not least, we perform a detailed error analysis and, in particular, quantify for the first time the statistical uncertainties of the fourth- and the considered sixth-order contact interactions.

Potassium conductance dynamics confer robust spike-time precision in a neuromorphic model of the auditory brain stem

PubMed Central

Boahen, Kwabena

2013-01-01

A fundamental question in neuroscience is how neurons perform precise operations despite inherent variability. This question also applies to neuromorphic engineering, where low-power microchips emulate the brain using large populations of diverse silicon neurons. Biological neurons in the auditory pathway display precise spike timing, critical for sound localization and interpretation of complex waveforms such as speech, even though they are a heterogeneous population. Silicon neurons are also heterogeneous, due to a key design constraint in neuromorphic engineering: smaller transistors offer lower power consumption and more neurons per unit area of silicon, but also more variability between transistors and thus between silicon neurons. Utilizing this variability in a neuromorphic model of the auditory brain stem with 1,080 silicon neurons, we found that a low-voltage-activated potassium conductance (gKL) enables precise spike timing via two mechanisms: statically reducing the resting membrane time constant and dynamically suppressing late synaptic inputs. The relative contribution of these two mechanisms is unknown because blocking gKL in vitro eliminates dynamic adaptation but also lengthens the membrane time constant. We replaced gKL with a static leak in silico to recover the short membrane time constant and found that silicon neurons could mimic the spike-time precision of their biological counterparts, but only over a narrow range of stimulus intensities and biophysical parameters. The dynamics of gKL were required for precise spike timing robust to stimulus variation across a heterogeneous population of silicon neurons, thus explaining how neural and neuromorphic systems may perform precise operations despite inherent variability. PMID:23554436

On- and off-line monitoring of ion beam treatment

NASA Astrophysics Data System (ADS)

Parodi, Katia

2016-02-01

Ion beam therapy is an emerging modality for high precision radiation treatment of cancer. In comparison to conventional radiation sources (photons, electrons), ion beams feature major dosimetric advantages due to their finite range with a localized dose deposition maximum, the Bragg peak, which can be selectively adjusted in depth. However, due to several sources of treatment uncertainties, full exploitation of these dosimetric advantages in clinical practice would require the possibility to visualize the stopping position of the ions in vivo, ideally in real-time. To this aim, different imaging methods have been proposed and investigated, either pre-clinically or even clinically, based on the detection of prompt or delayed radiation following nuclear interaction of the beam with the irradiated tissue. However, the chosen or ad-hoc developed instrumentation has often relied on technologies originally conceived for different applications, thus compromising on the achievable performances for the sake of cost-effectiveness. This contribution will review major examples of used instrumentation and related performances, identifying the most promising detector developments for next generation devices especially dedicated to on-line monitoring of ion beam treatment. Moreover, it will propose an original combination of different techniques in a hybrid detection scheme, aiming to make the most of complementary imaging methods and open new perspectives of image guidance for improved precision of ion beam therapy.

Positive-Buoyancy Rover for Under Ice Mobility

NASA Technical Reports Server (NTRS)

Leichty, John M.; Klesh, Andrew T.; Berisford, Daniel F.; Matthews, Jaret B.; Hand, Kevin P.

2013-01-01

A buoyant rover has been developed to traverse the underside of ice-covered lakes and seas. The rover operates at the ice/water interface and permits direct observation and measurement of processes affecting freeze- over and thaw events in lake and marine environments. Operating along the 2- D ice-water interface simplifies many aspects of underwater exploration, especially when compared to submersibles, which have difficulty in station-keeping and precision mobility. The buoyant rover consists of an all aluminum body with two aluminum sawtooth wheels. The two independent body segments are sandwiched between four actuators that permit isolation of wheel movement from movement of the central tether spool. For normal operations, the wheels move while the tether spool feeds out line and the cameras on each segment maintain a user-controlled fixed position. Typically one camera targets the ice/water interface and one camera looks down to the lake floor to identify seep sources. Each wheel can be operated independently for precision turning and adjustments. The rover is controlled by a touch- tablet interface and wireless goggles enable real-time viewing of video streamed from the rover cameras. The buoyant rover was successfully deployed and tested during an October 2012 field campaign to investigate methane trapped in ice in lakes along the North Slope of Alaska.

Data-Driven Significance Estimation for Precise Spike Correlation

PubMed Central

Grün, Sonja

2009-01-01

The mechanisms underlying neuronal coding and, in particular, the role of temporal spike coordination are hotly debated. However, this debate is often confounded by an implicit discussion about the use of appropriate analysis methods. To avoid incorrect interpretation of data, the analysis of simultaneous spike trains for precise spike correlation needs to be properly adjusted to the features of the experimental spike trains. In particular, nonstationarity of the firing of individual neurons in time or across trials, a spike train structure deviating from Poisson, or a co-occurrence of such features in parallel spike trains are potent generators of false positives. Problems can be avoided by including these features in the null hypothesis of the significance test. In this context, the use of surrogate data becomes increasingly important, because the complexity of the data typically prevents analytical solutions. This review provides an overview of the potential obstacles in the correlation analysis of parallel spike data and possible routes to overcome them. The discussion is illustrated at every stage of the argument by referring to a specific analysis tool (the Unitary Events method). The conclusions, however, are of a general nature and hold for other analysis techniques. Thorough testing and calibration of analysis tools and the impact of potentially erroneous preprocessing stages are emphasized. PMID:19129298

Design and realization of the control system for the three-channel birefringent filter

NASA Astrophysics Data System (ADS)

Zhu, Dan

2008-07-01

Space Solar Telescope is one of the large-scale scientific programs under development in China. In it, an important part is the filter, a birefringent filter with three-channels. It consists of 17 rotatable wave plates. In coordination with other mechanical and optical components, complicated and precise adjustments of their attitudes are necessary, which requests a high-accuracy control system to ensure their concertedness. The paper describes the design and realization of the control system. It mainly has a hardware plate and a software one. The former uses an industrial controller, a control card and step motors, while the latter uses the technique construction of the object oriented. That is modularization design with lengthwise dividing as per functions and breadthwise dividing as per element layers. Shift arithmetic for whole spectrum in programs is for intelligent spectral scanning. At the same time, the control information is roundly recorded in the data base of the system. Tests show that the system is characterized by high precision, good stabilization, high data safety and user-friendly interface, totally meeting the design requirements. Also discussed in this paper is some new conceivability to realize the handiness and miniaturization of the filter to fit the use in space flight in the future.

A simplified Integer Cosine Transform and its application in image compression

NASA Technical Reports Server (NTRS)

Costa, M.; Tong, K.

1994-01-01

A simplified version of the integer cosine transform (ICT) is described. For practical reasons, the transform is considered jointly with the quantization of its coefficients. It differs from conventional ICT algorithms in that the combined factors for normalization and quantization are approximated by powers of two. In conventional algorithms, the normalization/quantization stage typically requires as many integer divisions as the number of transform coefficients. By restricting the factors to powers of two, these divisions can be performed by variable shifts in the binary representation of the coefficients, with speed and cost advantages to the hardware implementation of the algorithm. The error introduced by the factor approximations is compensated for in the inverse ICT operation, executed with floating point precision. The simplified ICT algorithm has potential applications in image-compression systems with disparate cost and speed requirements in the encoder and decoder ends. For example, in deep space image telemetry, the image processors on board the spacecraft could take advantage of the simplified, faster encoding operation, which would be adjusted on the ground, with high-precision arithmetic. A dual application is found in compressed video broadcasting. Here, a fast, high-performance processor at the transmitter would precompensate for the factor approximations in the inverse ICT operation, to be performed in real time, at a large number of low-cost receivers.

Non-Invasive Monitoring of Cardiac Output in Critical Care Medicine.

PubMed

Nguyen, Lee S; Squara, Pierre

2017-01-01

Critically ill patients require close hemodynamic monitoring to titrate treatment on a regular basis. It allows administering fluid with parsimony and adjusting inotropes and vasoactive drugs when necessary. Although invasive monitoring is considered as the reference method, non-invasive monitoring presents the obvious advantage of being associated with fewer complications, at the expanse of accuracy, precision, and step-response change. A great many methods and devices are now used over the world, and this article focuses on several of them, providing with a brief review of related underlying physical principles and validation articles analysis. Reviewed methods include electrical bioimpedance and bioreactance, respiratory-derived cardiac output (CO) monitoring technique, pulse wave transit time, ultrasound CO monitoring, multimodal algorithmic estimation, and inductance thoracocardiography. Quality criteria with which devices were reviewed included: accuracy (closeness of agreement between a measurement value and a true value of the measured), precision (closeness of agreement between replicate measurements on the same or similar objects under specified conditions), and step response change (delay between physiological change and its indication). Our conclusion is that the offer of non-invasive monitoring has improved in the past few years, even though further developments are needed to provide clinicians with sufficiently accurate devices for routine use, as alternative to invasive monitoring devices.

Precise nanoliter fluid handling system with integrated high-speed flow sensor.

PubMed

Haber, Carsten; Boillat, Marc; van der Schoot, Bart

2005-04-01

A system for accurate low-volume delivery of liquids in the micro- to nanoliter range makes use of an integrated miniature flow sensor as part of an intelligent feedback control loop driving a micro-solenoid valve. The flow sensor is hydraulically connected with the pressurized system liquid in the dispensing channel and located downstream from the pressure source, above the solenoid valve. The sensor operates in a differential mode and responds in real-time to the internal flow-pulse resulting from the brief opening interval of the solenoid valve leading to a rapid ejection of a fluid droplet. The integral of the flow-pulse delivered by the sensor is directly proportional to the volume of the ejected droplet from the nozzle. The quantitative information is utilized to provide active control of the effectively dispensed or aspirated volume by adjusting the solenoid valve accordingly. This process significantly enhances the precision of the fluid delivery. The system furthermore compensates automatically for any changes in the viscosity of the dispensed liquid. The data delivered by the flow sensor can be saved and backtracked in order to confirm and validate the aspiration and dispensing process in its entirety. The collected dispense information can be used for quality control assessments and automatically be made part of an electronic record.

Investigation into the common mode rejection ratio of the physiological signal conditioner circuit

NASA Technical Reports Server (NTRS)

Obrien, Edward M.

1992-01-01

The common mode rejection ratio (CMRR) of the single operational amplifier (op amp) differential amplifier and of the three operational amplifier differential amplifier was investigated. The three op amp differential amplifier circuit is used in the signal conditioner circuit which amplifies signals such as the electromyograph or electrocardiogram. The investigation confirmed via SPICE modeling what has been observed by others in the recent literature that the CMRR for the circuit can be maximized without precision resistor values or precisely matched op amps. This can be done if one resistor in the final stage can be adjusted either by a potentiometer or by laser trimming in the case of hybrid circuit fabrication.

Microcomputer-based Peltier thermostat for precision optical radiation measurements

NASA Astrophysics Data System (ADS)

Zhu, Xiaosong; Krochmann, Eike; Chen, Jiashu

1992-03-01

We have developed a microcomputer-based thermostat for a light measuring head in precision optical radiation measurements. This thermostat consists of a single-chip microcomputer, a digital-to-analog converter, a liquid crystal display, a power operational amplifier, and a Peltier element (thermoelectric cooler). The Peltier element keeps the temperature of the photometer head at 20±0.1 °C in the ambient temperature range from -20 to 60 °C. A control algorithm which combines the ``Bang-Bang'' mode and proportional-plus-integral-plus-derivative mode is used to achieve fast and smooth thermostatic performance. This thermostat is effective, inexpensive, and easy to adjust. Several applications of the Peltier thermostat are mentioned.

High-dimensional atom localization via spontaneously generated coherence in a microwave-driven atomic system.

PubMed

Wang, Zhiping; Chen, Jinyu; Yu, Benli

2017-02-20

We investigate the two-dimensional (2D) and three-dimensional (3D) atom localization behaviors via spontaneously generated coherence in a microwave-driven four-level atomic system. Owing to the space-dependent atom-field interaction, it is found that the detecting probability and precision of 2D and 3D atom localization behaviors can be significantly improved via adjusting the system parameters, the phase, amplitude, and initial population distribution. Interestingly, the atom can be localized in volumes that are substantially smaller than a cubic optical wavelength. Our scheme opens a promising way to achieve high-precision and high-efficiency atom localization, which provides some potential applications in high-dimensional atom nanolithography.

Control system and method for a power delivery system having a continuously variable ratio transmission

DOEpatents

Frank, A.A.

1984-07-10

A control system and method for a power delivery system, such as in an automotive vehicle, having an engine coupled to a continuously variable ratio transmission (CVT). Totally independent control of engine and transmission enable the engine to precisely follow a desired operating characteristic, such as the ideal operating line for minimum fuel consumption. CVT ratio is controlled as a function of commanded power or torque and measured load, while engine fuel requirements (e.g., throttle position) are strictly a function of measured engine speed. Fuel requirements are therefore precisely adjusted in accordance with the ideal characteristic for any load placed on the engine. 4 figs.

The progress on time & frequency during the past 5 decades

NASA Astrophysics Data System (ADS)

Wang, Zheng-Ming

2002-06-01

The number and variety of applications using precise timing are astounding and increasing along with the new technology in communication, computer science, space science as well as in other fields. The world has evolved into the information age, and precise timing is at the heart of managing the flow of that information, which prompts the progress on precise timing itself rapidly. The development of time scales, UT1 determination, frequency standards, time transfer and the time dissemination for the past half century in the world and in China are described in this paper. The expectation in this field is discussed.

The 25th Annual Precise Time and Time Interval (PTTI) Applications and Planning Meeting

NASA Technical Reports Server (NTRS)

Sydnor, Richard L. (Editor)

1994-01-01

Papers in the following categories are presented: recent developments in rubidium, cesium, and hydrogen-based frequency standards, and in cryogenic and trapped-ion technology; international and transnational applications of precise time and time interval (PTTI) technology with emphasis on satellite laser tracking networks, GLONASS timing, intercomparison of national time scales and international telecommunication; applications of PTTI technology to the telecommunications, power distribution, platform positioning, and geophysical survey industries; application of PTTI technology to evolving military communications and navigation systems; and dissemination of precise time and frequency by means of GPS, GLONASS, MILSTAR, LORAN, and synchronous communications satellites.

MINOS Timing and GPS Precise Point Positioning

DTIC Science & Technology

2012-01-01

Minos Timing Spec • Neutrinos created in bunches separated by 19 ns • ~ 1 neutrino/day detected in Soudan Mine – 2 milliseconds travel time...calibration – No low-cost Fermilab to Soudan Mine connections known – Not yet tested for operational time transfer Clock Options • High-Performance... UNDERGROUND LABORATORY •;, ~ (((ft.F ~’: · GPS PRECISE POINT POSITIONING A Brief Overview What is GPS PPP? • GPS PPP is a way to use precise ephemerides

Cumulative Retrospective Exposure Assessment (REA) as a predictor of amphibole asbestos lung burden: validation procedures and results for industrial hygiene and pathology estimates.

PubMed

Rasmuson, James O; Roggli, Victor L; Boelter, Fred W; Rasmuson, Eric J; Redinger, Charles F

2014-01-01

A detailed evaluation of the correlation and linearity of industrial hygiene retrospective exposure assessment (REA) for cumulative asbestos exposure with asbestos lung burden analysis (LBA) has not been previously performed, but both methods are utilized for case-control and cohort studies and other applications such as setting occupational exposure limits. (a) To correlate REA with asbestos LBA for a large number of cases from varied industries and exposure scenarios; (b) to evaluate the linearity, precision, and applicability of both industrial hygiene exposure reconstruction and LBA; and (c) to demonstrate validation methods for REA. A panel of four experienced industrial hygiene raters independently estimated the cumulative asbestos exposure for 363 cases with limited exposure details in which asbestos LBA had been independently determined. LBA for asbestos bodies was performed by a pathologist by both light microscopy and scanning electron microscopy (SEM) and free asbestos fibers by SEM. Precision, reliability, correlation and linearity were evaluated via intraclass correlation, regression analysis and analysis of covariance. Plaintiff's answers to interrogatories, work history sheets, work summaries or plaintiff's discovery depositions that were obtained in court cases involving asbestos were utilized by the pathologist to provide a summarized brief asbestos exposure and work history for each of the 363 cases. Linear relationships between REA and LBA were found when adjustment was made for asbestos fiber-type exposure differences. Significant correlation between REA and LBA was found with amphibole asbestos lung burden and mixed fiber-types, but not with chrysotile. The intraclass correlation coefficients (ICC) for the precision of the industrial hygiene rater cumulative asbestos exposure estimates and the precision of repeated laboratory analysis were found to be in the excellent range. The ICC estimates were performed independent of specific asbestos fiber-type. Both REA and pathology assessment are reliable and complementary predictive methods to characterize asbestos exposures. Correlation analysis between the two methods effectively validates both REA methodology and LBA procedures within the determined precision, particularly for cumulative amphibole asbestos exposures since chrysotile fibers, for the most part, are not retained in the lung for an extended period of time.

Use of precision time and time interval (PTTI)

NASA Technical Reports Server (NTRS)

Taylor, J. D.

1974-01-01

A review of range time synchronization methods are discussed as an important aspect of range operations. The overall capabilities of various missile ranges to determine precise time of day by synchronizing to available references and applying this time point to instrumentation for time interval measurements are described.

Formation of precise 2D Au particle arrays via thermally induced dewetting on pre-patterned substrates

PubMed Central

Ji, Ran

2011-01-01

Summary The fabrication of precise 2D Au nanoparticle arrays over a large area is presented. The technique was based on pre-patterning of the substrate before the deposition of a thin Au film, and the creation of periodic particle arrays by subsequent dewetting induced by annealing. Two types of pre-patterned substrates were used: The first comprised an array of pyramidal pits and the second an array of circular holes. For the dewetting of Au films on the pyramidal pit substrate, the structural curvature-driven diffusion cooperates with capillarity-driven diffusion, resulting in the formation of precise 2D particle arrays for films within a structure dependent thickness-window. For the dewetting of Au films on the circular hole substrate, the periodic discontinuities in the films, induced by the deposition, can limit the diffusion paths and lead to the formation of one particle per individual separated region (holes or mesas between holes), and thus, result in the evolution of precise 2D particle arrays. The influence of the pre-patterned structures and the film thickness is analyzed and discussed. For both types of pre-patterned substrate, the Au film thickness had to be adjusted in a certain thickness-window in order to achieve the precise 2D particle arrays. PMID:21977445

The head-mounted microscope.

PubMed

Chen, Ting; Dailey, Seth H; Naze, Sawyer A; Jiang, Jack J

2012-04-01

Microsurgical equipment has greatly advanced since the inception of the microscope into the operating room. These advancements have allowed for superior surgical precision and better post-operative results. This study focuses on the use of the Leica HM500 head-mounted microscope for the operating phonosurgeon. The head-mounted microscope has an optical zoom from 2× to 9× and provides a working distance from 300 mm to 700 mm. The headpiece, with its articulated eyepieces, adjusts easily to head shape and circumference, and offers a focus function, which is either automatic or manually controlled. We performed five microlaryngoscopic operations utilizing the head-mounted microscope with successful results. By creating a more ergonomically favorable operating posture, a surgeon may be able to obtain greater precision and success in phonomicrosurgery. Phonomicrosurgery requires the precise manipulation of long-handled cantilevered instruments through the narrow bore of a laryngoscope. The head-mounted microscope shortens the working distance compared with a stand microscope, thereby increasing arm stability, which may improve surgical precision. Also, the head-mounted design permits flexibility in head position, enabling operator comfort, and delaying musculoskeletal fatigue. A head-mounted microscope decreases the working distance and provides better ergonomics in laryngoscopic microsurgery. These advances provide the potential to promote precision in phonomicrosurgery. Copyright © 2011 The American Laryngological, Rhinological, and Otological Society, Inc.

Aligning precisely polarization maintaining photonic crystal fiber and conventional single-mode fiber by online spectrum monitoring

NASA Astrophysics Data System (ADS)

Jiang, Ying; Zeng, Jie; Liang, Dakai; Ni, Xiaoyu; Luo, Wenyong

2013-06-01

The fibers aligning is very important in fusion splicing process. The core of polarization maintaining photonic crystal fiber(PM-PCF) can not be seen in the splicer due to microhole structure of its cross-section. So it is difficult to align precisely PM-PCF and conventional single-mode fiber(SMF).We demonstrate a novel method for aligning precisely PM-PCF and conventional SMF by online spectrum monitoring. Firstly, the light source of halogen lamp is connected to one end face of conventional SMF.Then align roughly one end face of PM-PCF and the other end face of conventional SMF by observing visible light in the other end face of PM-PCF. If there exists visible light, they are believed to align roughly. The other end face of PM-PCF and one end face of the other conventional SMF are aligned precisely in the other splicer by online spectrum monitoring. Now the light source of halogen lamp is changed into a broadband light source with 52nm wavelength range.The other end face of the other conventional SMF is connected to an optical spectrum analyzer.They are translationally and rotationally adjusted in the splicer by monitoring spectrum. When the transmission spectrum power is maximum, the aligning is precise.

Effects of parent drug use and personality on toddler adjustment.

PubMed

Brook, J S; Whiteman, M; Shapiro, J; Cohen, P

1996-03-01

The interrelation between parental drug use and parental personality and the effects on 18-month-old children's adjustment were examined. Data on the parents were available at four points in time: Time 1 at mean age 6.1 years, Time 2 at mean age 13.7 years, Time 3 at mean age 16.4 years, and at Time 4 at mean age 22.2 years. Data on their toddlers at 18 months of age were also available. Structured interviews were used to assess personality and drug use and the toddlers' adjustment. Time 3 parental personality traits were related to Time 4 personality traits, which in turn were related to toddler adjustment. The influence of parental alcohol involvement (Time 3) on toddler adjustment was mediated by parental personality (Times 3 and 4) and parental alcohol problems (Time 4). Interactive effects demonstrated that protective parental personality traits (nondrug conducive) enhanced the effects of low parental drug use, resulting in the highest amounts of toddler adjustment. There are significant pathways between parental personality and drug use and toddler adjustment. Parental protective factors enhance the effect of parental low drug use on toddler adjustment.

Precision slew/settle technologies for flexible spacecraft

NASA Technical Reports Server (NTRS)

Manning, R. A.; Spector, Victor A.

1993-01-01

Many spacecraft missions in the next decade will require both a high degree of agility and precision pointing. Agility includes both rotational maneuvering for retargeting and translational motion for orbit adjustment and threat avoidance. The major challenge associated with such missions is the need for control over a wide range of amplitudes and frequencies, ranging from tens of degrees at less than 1 Hz to a few micron radians at hundreds of Hz. TRW's internally funded Precision Control of Agile Spacecraft (PCAS) project is concerned with developing and validating in hardware the tools necessary to successfully complete the combined agile maneuvering/precision pointing missions. Development has been undertaken on a number of fronts for quietly slewing flexible structures. Various methods for designing slew torque profiles have been investigated. Prime candidates for slew/settle scenarios include Inverse Dynamics and Parameterized Function Space. Joint work with Processor Bayo at the University of California, Santa Barbara and Professor Flashner at the University of Southern California has led to promising torque profile design methods. Active and passive vibration suppression techniques also play a key role for rapid slew/settle mission scenarios. Active members with local control loops and passive members with high loss factor viscoelastic material have been selected for hardware verification. Progress in each of these areas produces large gains in the quiet slewing of flexible spacecraft. The main thrust of the effort to date has been the development of a modular testbed for hardware validation of the precision control concepts. The testbed is a slewing eighteen foot long flexible truss. Active and passive members can be interchanged with the baseline aluminum members to augment the inherent damping in the system. For precision control the active members utilize control laws running on a high speed digital structural control processor. Tip and midspan motions of the truss are determined using optical sensors while accelerometers can be used to monitor the motions of other points of interest. Preliminary results indicate that a mix of technologies produces the greatest benefit. For example, shaping the torque profile produces large improvements in slew/settle performance, but without added damping settling times may still be excessive. With the introduction of moderate amounts of damping, slew/settle performance is vastly improved. On the other hand, introducing damping without shaping the torque profile may not yield the desired level of performance.

A real-time surface inspection system for precision steel balls based on machine vision

NASA Astrophysics Data System (ADS)

Chen, Yi-Ji; Tsai, Jhy-Cherng; Hsu, Ya-Chen

2016-07-01

Precision steel balls are one of the most fundament components for motion and power transmission parts and they are widely used in industrial machinery and the automotive industry. As precision balls are crucial for the quality of these products, there is an urgent need to develop a fast and robust system for inspecting defects of precision steel balls. In this paper, a real-time system for inspecting surface defects of precision steel balls is developed based on machine vision. The developed system integrates a dual-lighting system, an unfolding mechanism and inspection algorithms for real-time signal processing and defect detection. The developed system is tested under feeding speeds of 4 pcs s-1 with a detection rate of 99.94% and an error rate of 0.10%. The minimum detectable surface flaw area is 0.01 mm2, which meets the requirement for inspecting ISO grade 100 precision steel balls.

Pb and Sr isotope measurements by inductively coupled plasma mass spectrometer: efficient time management for precision improvement

NASA Astrophysics Data System (ADS)

Monna, F.; Loizeau, J.-L.; Thomas, B. A.; Guéguen, C.; Favarger, P.-Y.

1998-08-01

One of the factors limiting the precision of inductively coupled plasma mass spectrometry is the counting statistics, which depend upon acquisition time and ion fluxes. In the present study, the precision of the isotopic measurements of Pb and Sr is examined. The time of measurement is optimally shared for each isotope, using a mathematical simulation, to provide the lowest theoretical analytical error. Different algorithms of mass bias correction are also taken into account and evaluated in term of improvement of overall precision. Several experiments allow a comparison of real conditions with theory. The present method significantly improves the precision, regardless of the instrument used. However, this benefit is more important for equipment which originally yields a precision close to that predicted by counting statistics. Additionally, the procedure is flexible enough to be easily adapted to other problems, such as isotopic dilution.

Proceedings of the 8th Precise Time and Time Interval (PTTI) Applications and Planning Meeting

NASA Technical Reports Server (NTRS)

1977-01-01

The Proceedings contain the papers presented at the Eight Annual Precise Time and Tme Interval PTTI Applications and Planning Meeting. The edited record of the discussions following the papers and the panel discussions are also included. This meeting provided a forum for the exchange of information on precise time and frequency technology among members of the scientific community and persons with program applications. The 282 registered attendees came from various U.S. Government agencies, private industry, universities and a number of foreign countries were represented. In this meeting, papers were presented that emphasized: (1) definitions and international regulations of precise time sources and users, (2) the scientific foundations of Hydrogen Maser standards, the current developments in this field and the application experience, and (3) how to measure the stability performance properties of precise standards. As in the previous meetings, update and new papers were presented on system applications with past, present and future requirements identified.

Nanosecond time transfer via shuttle laser ranging experiment

NASA Technical Reports Server (NTRS)

Reinhardt, V. S.; Premo, D. A.; Fitzmaurice, M. W.; Wardrip, S. C.; Cervenka, P. O.

1978-01-01

A method is described to use a proposed shuttle laser ranging experiment to transfer time with nanosecond precision. All that need be added to the original experiment are low cost ground stations and an atomic clock on the shuttle. It is shown that global time transfer can be accomplished with 1 ns precision and transfer up to distances of 2000 km can be accomplished with better than 100 ps precision.

Accuracy Validation of Large-scale Block Adjustment without Control of ZY3 Images over China

NASA Astrophysics Data System (ADS)

Yang, Bo

2016-06-01

Mapping from optical satellite images without ground control is one of the goals of photogrammetry. Using 8802 three linear array stereo images (a total of 26406 images) of ZY3 over China, we propose a large-scale and non-control block adjustment method of optical satellite images based on the RPC model, in which a single image is regarded as an adjustment unit to be organized. To overcome the block distortion caused by unstable adjustment without ground control and the excessive accumulation of errors, we use virtual control points created by the initial RPC model of the images as the weighted observations and add them into the adjustment model to refine the adjustment. We use 8000 uniformly distributed high precision check points to evaluate the geometric accuracy of the DOM (Digital Ortho Model) and DSM (Digital Surface Model) production, for which the standard deviations of plane and elevation are 3.6 m and 4.2 m respectively. The geometric accuracy is consistent across the whole block and the mosaic accuracy of neighboring DOM is within a pixel, thus, the seamless mosaic could take place. This method achieves the goal of an accuracy of mapping without ground control better than 5 m for the whole China from ZY3 satellite images.

A new theory of gravity.

NASA Technical Reports Server (NTRS)

Ni, W.-T.

1973-01-01

A new relativistic theory of gravity is presented. This theory agrees with all experiments to date. It is a metric theory; it is Lagrangian-based; and it possesses a preferred frame with conformally flat space slices. With an appropriate choice of certain adjustable functions and parameters and of the cosmological model, this theory possesses precisely the same post-Newtonian limit as general relativity.

Guarded Motion for Mobile Robots

DOE Office of Scientific and Technical Information (OSTI.GOV)

2005-03-30

The Idaho National Laboratory (INL) has created codes that ensure that a robot will come to a stop at a precise, specified distance from any obstacle regardless of the robot's initial speed, its physical characteristics, and the responsiveness of the low-level motor control schema. This Guarded Motion for Mobile Robots system iteratively adjusts the robot's action in response to information about the robot's environment.

Combining technologies: a computerized occlusal analysis system synchronized with a computerized electromyography system.

PubMed

Kerstein, Robert B

2004-04-01

Current advances in computer technologies have afforded dentists precision ways to examine occlusal contacts and muscle function. Recently, two separate computer technologies have been synchronized together, so that an operator can record their separate diagnostic data simultaneously. The two systems are: the T Scan II Occlusal Analysis System and the Biopak Electromyography Recording System. The simultaneous recording and playback capacity of these two computer systems allows the operator to analyze and correlate specific occlusal moments to specific electromyographic changes that result from these occlusal moments. This synchronization provides unparalleled evidence of the effect occlusal contact arrangement has on muscle function. Therefore, the occlusal condition of an inserted dental prosthesis or the occlusal scheme of the natural teeth (before and after corrective occlusal adjustments) can be readily evaluated, documented, and quantified for both, quality of occlusal parameters and muscle activity and the responses to the quality of the occlusal condition. This article describes their synchronization and illustrates their use in performing precision occlusal adjustment procedures on two patients: one who demonstrates occlusal disharmony while exhibiting the signs and symptoms of chronic myofascial pain dysfunction syndrome, and the other who had extensive restorative work accomplished but exhibits occlusal discomfort post-operatively.

Patterns of Unit and Item Nonresponse in the CAHPS® Hospital Survey

PubMed Central

Elliott, Marc N; Edwards, Carol; Angeles, January; Hambarsoomians, Katrin; Hays, Ron D

2005-01-01

Objective To examine the predictors of unit and item nonresponse, the magnitude of nonresponse bias, and the need for nonresponse weights in the Consumer Assessment of Health Care Providers and Systems (CAHPS®) Hospital Survey. Methods A common set of 11 administrative variables (41 degrees of freedom) was used to predict unit nonresponse and the rate of item nonresponse in multivariate models. Descriptive statistics were used to examine the impact of nonresponse on CAHPS Hospital Survey ratings and reports. Results Unit nonresponse was highest for younger patients and patients other than non-Hispanic whites (p<.001); item nonresponse increased steadily with age (p<.001). Fourteen of 20 reports of ratings of care had significant (p<.05) but small negative correlations with nonresponse weights (median −0.06; maximum −0.09). Nonresponse weights do not improve overall precision below sample sizes of 300–1,000, and are unlikely to improve the precision of hospital comparisons. In some contexts, case-mix adjustment eliminates most observed nonresponse bias. Conclusions Nonresponse weights should not be used for between-hospital comparisons of the CAHPS Hospital Survey, but may make small contributions to overall estimates or demographic comparisons, especially in the absence of case-mix adjustment. PMID:16316440

Operational Concept for Flight Crews to Participate in Merging and Spacing of Aircraft

NASA Technical Reports Server (NTRS)

Baxley, Brian T.; Barmore, Bryan E.; Abbott, Terence S.; Capron, William R.

2006-01-01

The predicted tripling of air traffic within the next 15 years is expected to cause significant aircraft delays and create a major financial burden for the airline industry unless the capacity of the National Airspace System can be increased. One approach to improve throughput and reduce delay is to develop new ground tools, airborne tools, and procedures to reduce the variance of aircraft delivery to the airport, thereby providing an increase in runway throughput capacity and a reduction in arrival aircraft delay. The first phase of the Merging and Spacing Concept employs a ground based tool used by Air Traffic Control that creates an arrival time to the runway threshold based on the aircraft s current position and speed, then makes minor adjustments to that schedule to accommodate runway throughput constraints such as weather and wake vortex separation criteria. The Merging and Spacing Concept also employs arrival routing that begins at an en route metering fix at altitude and continues to the runway threshold with defined lateral, vertical, and velocity criteria. This allows the desired spacing interval between aircraft at the runway to be translated back in time and space to the metering fix. The tool then calculates a specific speed for each aircraft to fly while enroute to the metering fix based on the adjusted land timing for that aircraft. This speed is data-linked to the crew who fly this speed, causing the aircraft to arrive at the metering fix with the assigned spacing interval behind the previous aircraft in the landing sequence. The second phase of the Merging and Spacing Concept increases the timing precision of the aircraft delivery to the runway threshold by having flight crews using an airborne system make minor speed changes during enroute, descent, and arrival phases of flight. These speed changes are based on broadcast aircraft state data to determine the difference between the actual and assigned time interval between the aircraft pair. The airborne software then calculates a speed adjustment to null that difference over the remaining flight trajectory. Follow-on phases still under development will expand the concept to all types of aircraft, arriving from any direction, merging at different fixes and altitudes, and to any airport. This paper describes the implementation phases of the Merging and Spacing Concept, and provides high-level results of research conducted to date.

Flow-guided sketch and accentuated-tone adjusting for pencil drawing generation

NASA Astrophysics Data System (ADS)

Li, Ruirui; Yang, Lei; Hu, Wei

2017-07-01

Pencil drawing is an important artistic style which is widely used in draft sketch and finished rendering. It is non-trivial if we can automatically generate the pencil drawing more precisely in order to ease the human efforts. In this paper, we propose flow-guided sketch and accentuated-tone adjusting techniques to transform the pencil drawing from natural images. This work is extended from the existing pencil drawing framework where authors combine sketch and tone together for penciling purpose. Through an edge tangent flow guided classification and convolution, we can obtain more coherent and smooth strokes, especially for portraits. In addition, we also introduce a hierarchical approach to generate strokes. According to saliency map, we can adjust the tone of images automatically. The experimental results indicate the generated toned pencil drawings by our approach are of fewer artifacts and could even solve the images with dark background

Support mechanism for a mirrored surface or other arrangement

DOEpatents

Cutburth, Ronald W.

1987-01-01

An adjustment mechanism such as a three point spherical mount for adjustably supporting a planer mirror or other type of arrangement relative to a plane defined by a given pair of intersecting perpendicular axes is disclosed herein. This mechanism includes first means for fixedly supporting the mirror or other arrangement such that the latter is positionable within the plane defined by the given pair of intersecting perpendicular axes. This latter means and the mirror or other such arrangement are supported by second means for limited movement back and forth about either of the intersecting axes. Moreover, this second means supports the first means and the mirror or other arrangement such that the latter is not movable in any other way whereby the point on the mirror or other arrangement coinciding with the intersection of the given axes does not move or float, thereby making the ability to adjust the mirror or other such arrangement more precise and accurate.

LYSO based precision timing calorimeters

NASA Astrophysics Data System (ADS)

Bornheim, A.; Apresyan, A.; Ronzhin, A.; Xie, S.; Duarte, J.; Spiropulu, M.; Trevor, J.; Anderson, D.; Pena, C.; Hassanshahi, M. H.

2017-11-01

In this report we outline the study of the development of calorimeter detectors using bright scintillating crystals. We discuss how timing information with a precision of a few tens of pico seconds and below can significantly improve the reconstruction of the physics events under challenging high pileup conditions to be faced at the High-Luminosity LHC or a future hadron collider. The particular challenge in measuring the time of arrival of a high energy photon lies in the stochastic component of the distance of initial conversion and the size of the electromagnetic shower. We present studies and measurements from test beams for calorimeter based timing measurements to explore the ultimate timing precision achievable for high energy photons of 10 GeV and above. We focus on techniques to measure the timing with a high precision in association with the energy of the photon. We present test-beam studies and results on the timing performance and characterization of the time resolution of LYSO-based calorimeters. We demonstrate time resolution of 30 ps is achievable for a particular design.

Note: electronic circuit for two-way time transfer via a single coaxial cable with picosecond accuracy and precision.

PubMed

Prochazka, Ivan; Kodet, Jan; Panek, Petr

2012-11-01

We have designed, constructed, and tested the overall performance of the electronic circuit for the two-way time transfer between two timing devices over modest distances with sub-picosecond precision and a systematic error of a few picoseconds. The concept of the electronic circuit enables to carry out time tagging of pulses of interest in parallel to the comparison of the time scales of these timing devices. The key timing parameters of the circuit are: temperature change of the delay is below 100 fs/K, timing stability time deviation better than 8 fs for averaging time from minutes to hours, sub-picosecond time transfer precision, and a few picoseconds time transfer accuracy.

Multi-GNSS real-time precise orbit/clock/UPD products and precise positioning service at GFZ

NASA Astrophysics Data System (ADS)

Li, Xingxing; Ge, Maorong; Liu, Yang; Fritsche, Mathias; Wickert, Jens; Schuh, Harald

2016-04-01

The rapid development of multi-constellation GNSSs (Global Navigation Satellite Systems, e.g., BeiDou, Galileo, GLONASS, GPS) and the IGS (International GNSS Service) Multi-GNSS Experiment (MGEX) bring great opportunities and challenges for real-time precise positioning service. In this contribution, we present a GPS+GLONASS+BeiDou+Galileo four-system model to fully exploit the observations of all these four navigation satellite systems for real-time precise orbit determination, clock estimation and positioning. A rigorous multi-GNSS analysis is performed to achieve the best possible consistency by processing the observations from different GNSS together in one common parameter estimation procedure. Meanwhile, an efficient multi-GNSS real-time precise positioning service system is designed and demonstrated by using the Multi-GNSS Experiment (MGEX) and International GNSS Service (IGS) data streams including stations all over the world. The addition of the BeiDou, Galileo and GLONASS systems to the standard GPS-only processing, reduces the convergence time almost by 70%, while the positioning accuracy is improved by about 25%. Some outliers in the GPS-only solutions vanish when multi-GNSS observations are processed simultaneous. The availability and reliability of GPS precise positioning decrease dramatically as the elevation cutoff increases. However, the accuracy of multi-GNSS precise point positioning (PPP) is hardly decreased and few centimeters are still achievable in the horizontal components even with 40° elevation cutoff.

Further analysis of clinical feasibility of OCT-based glaucoma diagnosis with Pigment epithelium central limit- Inner limit of the retina Minimal Distance (PIMD)

NASA Astrophysics Data System (ADS)

Söderberg, Per G.; Malmberg, Filip; Sandberg-Melin, Camilla

2017-02-01

The present study aimed to elucidate if comparison of angular segments of Pigment epithelium central limit- Inner limit of the retina Minimal Distance, measured over 2π radians in the frontal plane (PIMD-2π) between visits of a patient, renders sufficient precision for detection of loss of nerve fibers in the optic nerve head. An optic nerve head raster scanned cube was captured with a TOPCON 3D OCT 2000 (Topcon, Japan) device in one early to moderate stage glaucoma eye of each of 13 patients. All eyes were recorded at two visits less than 1 month apart. At each visit, 3 volumes were captured. Each volume was extracted from the OCT device for analysis. Then, angular PIMD was segmented three times over 2π radians in the frontal plane, resolved with a semi-automatic algorithm in 500 equally separated steps, PIMD-2π. It was found that individual segmentations within volumes, within visits, within subjects can be phase adjusted to each other in the frontal plane using cross-correlation. Cross correlation was also used to phase adjust volumes within visits within subjects and visits to each other within subjects. Then, PIMD-2π for each subject was split into 250 bundles of 2 adjacent PIMDs. Finally, the sources of variation for estimates of segments of PIMD-2π were derived with analysis of variance assuming a mixed model. The variation among adjacent PIMDS was found very small in relation to the variation among segmentations. The variation among visits was found insignificant in relation to the variation among volumes and the variance for segmentations was found to be on the order of 20 % of that for volumes. The estimated variances imply that, if 3 segmentations are averaged within a volume and at least 10 volumes are averaged within a visit, it is possible to estimate around a 10 % reduction of a PIMD-2π segment from baseline to a subsequent visit as significant. Considering a loss rate for a PIMD-2π segment of 23 μm/yr., 4 visits per year, and averaging 3 segmentations per volume and 3 volumes per visit, a significant reduction from baseline can be detected with a power of 80 % in about 18 months. At higher loss rate for a PIMD-2π segment, a significant difference from baseline can be detected earlier. Averaging over more volumes per visit considerably decreases the time for detection of a significant reduction of a segment of PIMD-2π. Increasing the number of segmentations averaged per visit only slightly reduces the time for detection of a significant reduction. It is concluded that phase adjustment in the frontal plane with cross correlation allows high precision estimates of a segment of PIMD-2π that imply substantially shorter followup time for detection of a significant change than mean deviation (MD) in a visual field estimated with the Humphrey perimeter or neural rim area (NRA) estimated with the Heidelberg retinal tomograph.

Detection of small orientation changes and the precision of visual working memory.

PubMed

Salmela, Viljami R; Saarinen, Jussi

2013-01-14

We investigated the precision of orientation representations with two tasks, change detection and recall. Previously change detection has been measured only with relatively large orientation changes compared to psychophysical thresholds. In the first experiment, we measured the observers' ability (d') to detect small changes in orientation (5-30°) with 1-4 Gabor items. With one item even a 10° change was well detected (average d'=2.5). As the amount of change increased to 30°, the d' increased to 5.2. When the number of items was increased, the d's gradually decreased. In the second experiment, we used a recall task and the observers adjusted the orientation of a probe Gabor to match the orientation of a Gabor held in the memory. The standard deviation (s.d.) of errors was calculated from the Gaussian distribution fitted to the data. As the number of items increased from 1 to 6, the s.d. increased from 8.6° to 19.6°. Even with six items, the observers did not make any random adjustments. The results show a square root relation between the d'/s.d. and the number of items. The d' in change detection is directly proportional to the square root of (1/n) and the orientation change. The increase of the s.d. in recall task is inversely proportional to square root of (1/n). The results suggest that limited resources and precision of representations, without additional assumptions, determine the memory performance. Copyright © 2012 Elsevier Ltd. All rights reserved.

A 3.9 ps Time-Interval RMS Precision Time-to-Digital Converter Using a Dual-Sampling Method in an UltraScale FPGA

NASA Astrophysics Data System (ADS)

Wang, Yonggang; Liu, Chong

2016-10-01

Field programmable gate arrays (FPGAs) manufactured with more advanced processing technology have faster carry chains and smaller delay elements, which are favorable for the design of tapped delay line (TDL)-style time-to-digital converters (TDCs) in FPGA. However, new challenges are posed in using them to implement TDCs with a high time precision. In this paper, we propose a bin realignment method and a dual-sampling method for TDC implementation in a Xilinx UltraScale FPGA. The former realigns the disordered time delay taps so that the TDC precision can approach the limit of its delay granularity, while the latter doubles the number of taps in the delay line so that the TDC precision beyond the cell delay limitation can be expected. Two TDC channels were implemented in a Kintex UltraScale FPGA, and the effectiveness of the new methods was evaluated. For fixed time intervals in the range from 0 to 440 ns, the average RMS precision measured by the two TDC channels reaches 5.8 ps using the bin realignment, and it further improves to 3.9 ps by using the dual-sampling method. The time precision has a 5.6% variation in the measured temperature range. Every part of the TDC, including dual-sampling, encoding, and on-line calibration, could run at a 500 MHz clock frequency. The system measurement dead time is only 4 ns.

Precision electronic speed controller for an alternating-current motor

DOEpatents

Bolie, V.W.

A high precision controller for an alternating-current multi-phase electrical motor that is subject to a large inertial load. The controller was developed for controlling, in a neutron chopper system, a heavy spinning rotor that must be rotated in phase-locked synchronism with a reference pulse train that is representative of an ac power supply signal having a meandering line frequency. The controller includes a shaft revolution sensor which provides a feedback pulse train representative of the actual speed of the motor. An internal digital timing signal generator provides a reference signal which is compared with the feedback signal in a computing unit to provide a motor control signal. The motor control signal is a weighted linear sum of a speed error voltage, a phase error voltage, and a drift error voltage, each of which is computed anew with each revolution of the motor shaft. The speed error signal is generated by a novel vernier-logic circuit which is drift-free and highly sensitive to small speed changes. The phase error is also computed by digital logic, with adjustable sensitivity around a 0 mid-scale value. The drift error signal, generated by long-term counting of the phase error, is used to compensate for any slow changes in the average friction drag on the motor. An auxillary drift-byte status sensor prevents any disruptive overflow or underflow of the drift-error counter. An adjustable clocked-delay unit is inserted between the controller and the source of the reference pulse train to permit phase alignment of the rotor to any desired offset angle. The stator windings of the motor are driven by two amplifiers which are provided with input signals having the proper quadrature relationship by an exciter unit consisting of a voltage controlled oscillator, a binary counter, a pair of read-only memories, and a pair of digital-to-analog converters.

Water vapor δ(2) H, δ(18) O and δ(17) O measurements using an off-axis integrated cavity output spectrometer - sensitivity to water vapor concentration, delta value and averaging-time.

PubMed

Tian, Chao; Wang, Lixin; Novick, Kimberly A

2016-10-15

High-precision analysis of atmospheric water vapor isotope compositions, especially δ(17) O values, can be used to improve our understanding of multiple hydrological and meteorological processes (e.g., differentiate equilibrium or kinetic fractionation). This study focused on assessing, for the first time, how the accuracy and precision of vapor δ(17) O laser spectroscopy measurements depend on vapor concentration, delta range, and averaging-time. A Triple Water Vapor Isotope Analyzer (T-WVIA) was used to evaluate the accuracy and precision of δ(2) H, δ(18) O and δ(17) O measurements. The sensitivity of accuracy and precision to water vapor concentration was evaluated using two international standards (GISP and SLAP2). The sensitivity of precision to delta value was evaluated using four working standards spanning a large delta range. The sensitivity of precision to averaging-time was assessed by measuring one standard continuously for 24 hours. Overall, the accuracy and precision of the δ(2) H, δ(18) O and δ(17) O measurements were high. Across all vapor concentrations, the accuracy of δ(2) H, δ(18) O and δ(17) O observations ranged from 0.10‰ to 1.84‰, 0.08‰ to 0.86‰ and 0.06‰ to 0.62‰, respectively, and the precision ranged from 0.099‰ to 0.430‰, 0.009‰ to 0.080‰ and 0.022‰ to 0.054‰, respectively. The accuracy and precision of all isotope measurements were sensitive to concentration, with the higher accuracy and precision generally observed under moderate vapor concentrations (i.e., 10000-15000 ppm) for all isotopes. The precision was also sensitive to the range of delta values, although the effect was not as large compared with the sensitivity to concentration. The precision was much less sensitive to averaging-time than the concentration and delta range effects. The accuracy and precision performance of the T-WVIA depend on concentration but depend less on the delta value and averaging-time. The instrument can simultaneously and continuously measure δ(2) H, δ(18) O and δ(17) O values in water vapor, opening a new window to better understand ecological, hydrological and meteorological processes. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Modeling and Assessment of Precise Time Transfer by Using BeiDou Navigation Satellite System Triple-Frequency Signals.

PubMed

Tu, Rui; Zhang, Pengfei; Zhang, Rui; Liu, Jinhai; Lu, Xiaochun

2018-03-29

This study proposes two models for precise time transfer using the BeiDou Navigation Satellite System triple-frequency signals: ionosphere-free (IF) combined precise point positioning (PPP) model with two dual-frequency combinations (IF-PPP1) and ionosphere-free combined PPP model with a single triple-frequency combination (IF-PPP2). A dataset with a short baseline (with a common external time frequency) and a long baseline are used for performance assessments. The results show that IF-PPP1 and IF-PPP2 models can both be used for precise time transfer using BeiDou Navigation Satellite System (BDS) triple-frequency signals, and the accuracy and stability of time transfer is the same in both cases, except for a constant system bias caused by the hardware delay of different frequencies, which can be removed by the parameter estimation and prediction with long time datasets or by a priori calibration.

The Pulkovo Cooperation for Radar and Optical Observations of Space Objects

NASA Astrophysics Data System (ADS)

Molotov, I.; Konovalenko, A. A.; Tuccari, G.; Falkovich, I.; Nechaeva, M.; Kiladze, R.; Titenko, V.; Agapov, V.; Khutorovsky, Z. N.; Sukhov, P. P.; Burtsev, Yu.; Sochilina, A.; Abalakin, V.; et al.

The Pulkovo observatory is arranging the cooperation of optical and radio telescopes for space debris studies in two main research directions, i.e. the precise tracking of the GEO-objects for development of the dynamical control method and the barrier method study of small fragments produced by GEO-object explosions.Radar experiments are being carried out a few times per year by using the Evpatoria RT-70 transmitter and the receiving radio telescopes in Bear Lakes (Russia), Simeiz (Ukraine), Noto (Italy), and Urumqi (China). The data processing centers are located in N. Novgorod and Noto, and integrated into the Low Frequency VLBI Network (LFVN). The adjustment of the coordinated radar VLBI measurements has been completed, and the technique of beam-track searching has been tested. The program of the LFVN modernizations is in progress The Pulkovo cooperation of optical observers (PULCOO) includes observatories and observation stations of the former Soviet Union around the world, and is to provide the routine tracking of the GEO-objects. The adjustment has been carried out for the method to search for GEO-fragments in the barriers predicted on basis of the Pulkovo "LAPLACE" theory of motion. The refurbishment program for telescopes, which cooperate with the PULCOO, is in progress.

Workplace social capital and all-cause mortality: a prospective cohort study of 28,043 public-sector employees in Finland.

PubMed

Oksanen, Tuula; Kivimäki, Mika; Kawachi, Ichiro; Subramanian, S V; Takao, Soshi; Suzuki, Etsuji; Kouvonen, Anne; Pentti, Jaana; Salo, Paula; Virtanen, Marianna; Vahtera, Jussi

2011-09-01

We examined the association between workplace social capital and all-cause mortality in a large occupational cohort from Finland. We linked responses of 28 043 participants to surveys in 2000 to 2002 and in 2004 to national mortality registers through 2009. We used repeated measurements of self- and coworker-assessed social capital. We carried out Cox proportional hazard and fixed-effects logistic regressions. During the 5-year follow-up, 196 employees died. A 1-unit increase in the mean of repeat measurements of self-assessed workplace social capital (range 1-5) was associated with a 19% decrease in the risk of all-cause mortality (age- and gender-adjusted hazard ratio [HR] = 0.81; 95% confidence interval [CI] = 0.66, 0.99). The corresponding point estimate for the mean of coworker-assessed social capital was similar, although the association was less precisely estimated (age- and gender-adjusted HR = 0.77; 95% CI = 0.50, 1.20). In fixed-effects analysis, a 1-unit increase in self-assessed social capital across the 2 time points was associated with a lower mortality risk (odds ratio = 0.81; 95% CI = 0.55, 1.19). Workplace social capital appears to be associated with lowered mortality in the working-aged population.

Workplace Social Capital and All-Cause Mortality: A Prospective Cohort Study of 28 043 Public-Sector Employees in Finland

PubMed Central

Kivimäki, Mika; Kawachi, Ichiro; Subramanian, S. V.; Takao, Soshi; Suzuki, Etsuji; Kouvonen, Anne; Pentti, Jaana; Salo, Paula; Virtanen, Marianna; Vahtera, Jussi

2011-01-01

Objectives. We examined the association between workplace social capital and all-cause mortality in a large occupational cohort from Finland. Methods. We linked responses of 28 043 participants to surveys in 2000 to 2002 and in 2004 to national mortality registers through 2009. We used repeated measurements of self- and coworker-assessed social capital. We carried out Cox proportional hazard and fixed-effects logistic regressions. Results. During the 5-year follow-up, 196 employees died. A 1-unit increase in the mean of repeat measurements of self-assessed workplace social capital (range 1–5) was associated with a 19% decrease in the risk of all-cause mortality (age- and gender-adjusted hazard ratio [HR] = 0.81; 95% confidence interval [CI] = 0.66, 0.99). The corresponding point estimate for the mean of coworker-assessed social capital was similar, although the association was less precisely estimated (age- and gender-adjusted HR = 0.77; 95% CI = 0.50, 1.20). In fixed-effects analysis, a 1-unit increase in self-assessed social capital across the 2 time points was associated with a lower mortality risk (odds ratio = 0.81; 95% CI = 0.55, 1.19). Conclusions. Workplace social capital appears to be associated with lowered mortality in the working-aged population. PMID:21778502

Tunable optical limiting optofluidic device filled with graphene oxide dispersion in ethanol

PubMed Central

Fang, Chaolong; Dai, Bo; Hong, Ruijin; Tao, Chunxian; Wang, Qi; Wang, Xu; Zhang, Dawei; Zhuang, Songlin

2015-01-01

An optofluidic device with tunable optical limiting property is proposed and demonstrated. The optofluidic device is designed for adjusting the concentration of graphene oxide (GO) in the ethanol solution and fabricated by photolithography technique. By controlling the flow rate ratio of the injection, the concentration of GO can be precisely adjusted so that the optical nonlinearity can be changed. The nonlinear optical properties and dynamic excitation relaxation of the GO/ethanol solution are investigated by using Z-scan and pump-probe measurements in the femtosecond regime within the 1.5 μm telecom band. The GO/ethanol solution presents ultrafast recovery time. Besides, the optical limiting property is in proportion to the concentration of the solution. Thus, the threshold power and the saturated power of the optical limiting property can be simply and efficiently manipulated by controlling the flow rate ratio of the injection. Furthermore, the amplitude regeneration is demonstrated by employing the proposed optofluidic device. The signal quality of intensity-impaired femtosecond pulse is significantly improved. The optofluidic device is compact and has long interaction length of optical field and nonlinear material. Heat can be dissipated in the solution and nonlinear material is isolated from other optical components, efficiently avoiding thermal damage and mechanical damage. PMID:26477662

Domain wall oscillation in magnetic nanowire with a geometrically confined region

NASA Astrophysics Data System (ADS)

Sbiaa, R.; Bahri, M. Al; Piramanayagam, S. N.

2018-06-01

In conventional magnetic devices such as magnetic tunnel junctions, a steady oscillation of a soft layer magnetization could find its application in various electronic systems. However, these devices suffer from their low output signal and large spectral linewidth. A more elegant scheme based on domain wall oscillation could be a solution to these issues if DW dynamics could be controlled precisely in space and time. In fact, in DW devices, the magnetic configuration of domain wall and its position are strongly dependent on the device geometry and material properties. Here we show that in a constricted device with judiciously adjusted dimensions, a DW can be trapped within the central part and keep oscillating with a single frequency f. For 200 nm by 40 nm nanowire, f was found to vary from 2 GHz to 3 GHz for a current density between 4.8 × 1012 A/m2 and 5.6 × 1012 A/m2. More interestingly, the device fabrication is simply based on two long nanowires connected by adjusting the offset in both x and y directions. This new type of devices enables the conversion of dc-current to an ac-voltage in a controllable manner opening thus the possibility of a new nano-oscillators with better performance.

Plasmonic metamaterial for electromagnetically induced transparency analogue and ultra-high figure of merit sensor

PubMed Central

Wu, Dong; Liu, Yumin; Yu, Li; Yu, Zhongyuan; Chen, Lei; Li, Ruifang; Ma, Rui; Liu, Chang; Zhang, Jinqiannan; Ye, Han

2017-01-01

In this work, using finite-difference time-domain method, we propose and numerically demonstrate a novel way to achieve electromagnetically induced transparency (EIT) phenomenon in the reflection spectrum by stacking two different types of coupling effect among different elements of the designed metamaterial. Compared with the conventional EIT-like analogues coming from only one type of coupling effect between bright and dark meta-atoms on the same plane, to our knowledge the novel approach is the first to realize the optically active and precise control of the wavelength position of EIT-like phenomenon using optical metamaterials. An on-to-off dynamic control of the EIT-like phenomenon also can be achieved by changing the refractive index of the dielectric substrate via adjusting an optical pump pulse. Furthermore, in near infrared region, the metamaterial structure can be operated as an ultra-high resolution refractive index sensor with an ultra-high figure of merit (FOM) reaching 3200, which remarkably improve the FOM value of plasmonic refractive index sensors. The novel approach realizing EIT-like spectral shape with easy adjustment to the working wavelengths will open up new avenues for future research and practical application of active plasmonic switch, ultra-high resolution sensors and active slow-light devices. PMID:28332629

Application of a Compact High-Definition Exoscope for Illumination and Magnification in High-Precision Surgical Procedures.

PubMed

Krishnan, Kartik G; Schöller, Karsten; Uhl, Eberhard

2017-01-01

The basic necessities for surgical procedures are illumination, exposure, and magnification. These have undergone transformation in par with technology. One of the recent developments is the compact magnifying exoscope system. In this report, we describe the application of this system for surgical operations and discuss its advantages and pitfalls. We used the ViTOM exoscope mounted on the mechanical holding arm. The following surgical procedures were conducted: lumbar and cervical spinal canal decompression (n = 5); laminotomy and removal of lumbar migrated disk herniations (n = 4); anterior cervical diskectomy and fusion (n = 1); removal of intraneural schwannomas (n = 2); removal of an acute cerebellar hemorrhage (n = 1); removal of a parafalcine atypical cerebral hematoma caused by a dural arteriovenous fistula (n = 1); and microsutures and anastomoses of a nerve (n = 1), an artery (n = 1), and veins (n = 2). The exoscope offered excellent, magnified, and brilliantly illuminated high-definition images of the surgical field. All surgical operations were successfully completed. The main disadvantage was the adjustment and refocusing using the mechanical holding arm. The time required for the surgical operation under the exoscope was slightly longer than the times required for a similar procedure performed using an operating microscope. The magnifying exoscope is an effective and nonbulky tool for surgical procedures. In visualization around the corners, the exoscope has better potential than a microscope. With technical and technologic modifications, the exoscope might become the next generation in illumination, visualization, exposure, and magnification for high-precision surgical procedures. Copyright © 2016 Elsevier Inc. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sunayama, Tomomi; Padmanabhan, Nikhil; Heitmann, Katrin

Precision measurements of the large scale structure of the Universe require large numbers of high fidelity mock catalogs to accurately assess, and account for, the presence of systematic effects. We introduce and test a scheme for generating mock catalogs rapidly using suitably derated N-body simulations. Our aim is to reproduce the large scale structure and the gross properties of dark matter halos with high accuracy, while sacrificing the details of the halo's internal structure. By adjusting global and local time-steps in an N-body code, we demonstrate that we recover halo masses to better than 0.5% and the power spectrum tomore » better than 1% both in real and redshift space for k =1 h Mpc{sup −1}, while requiring a factor of 4 less CPU time. We also calibrate the redshift spacing of outputs required to generate simulated light cones. We find that outputs separated by Δ z =0.05 allow us to interpolate particle positions and velocities to reproduce the real and redshift space power spectra to better than 1% (out to k =1 h Mpc{sup −1}). We apply these ideas to generate a suite of simulations spanning a range of cosmologies, motivated by the Baryon Oscillation Spectroscopic Survey (BOSS) but broadly applicable to future large scale structure surveys including eBOSS and DESI. As an initial demonstration of the utility of such simulations, we calibrate the shift in the baryonic acoustic oscillation peak position as a function of galaxy bias with higher precision than has been possible so far. This paper also serves to document the simulations, which we make publicly available.« less

Age-related differences in finger force control are characterized by reduced force production.

PubMed

Vieluf, Solveig; Godde, Ben; Reuter, Eva-Maria; Voelcker-Rehage, Claudia

2013-01-01

It has been repeatedly shown that precise finger force control declines with age. The tasks and evaluation parameters used to reveal age-related differences vary between studies. In order to examine effects of task characteristics, young adults (18-25 years) and late middle-aged adults (55-65 years) performed precision grip tasks with varying speed and force requirements. Different outcome variables were used to evaluate age-related differences. Age-related differences were confirmed for performance accuracy (TWR) and variability (relative root mean square error, rRMSE). The task characteristics, however, influenced accuracy and variability in both age groups: Force modulation performance at higher speed was poorer than at lower speed and at fixed force levels than at force levels adjusted to the individual maximum forces. This effect tended to be stronger for older participants for the rRMSE. A curve fit confirmed the age-related differences for both spatial force tracking parameters (amplitude and intercept) and for one temporal parameter (phase shift), but not for the temporal parameter frequency. Additionally, matching the timing parameters of the sine wave seemed to be more important than matching the spatial parameters in both young adults and late middle-aged adults. However, the effect was stronger for the group of late middle-aged, even though maximum voluntary contraction was not significantly different between groups. Our data indicate that changes in the processing of fine motor control tasks with increasing age are caused by difficulties of late middle-aged adults to produce a predefined amount of force in a short time.

Method and apparatus for analog pulse pile-up rejection

DOEpatents

De Geronimo, Gianluigi

2013-12-31

A method and apparatus for pulse pile-up rejection are disclosed. The apparatus comprises a delay value application constituent configured to receive a threshold-crossing time value, and provide an adjustable value according to a delay value and the threshold-crossing time value; and a comparison constituent configured to receive a peak-occurrence time value and the adjustable value, compare the peak-occurrence time value with the adjustable value, indicate pulse acceptance if the peak-occurrence time value is less than or equal to the adjustable value, and indicate pulse rejection if the peak-occurrence time value is greater than the adjustable value.

Method and apparatus for analog pulse pile-up rejection

DOEpatents

De Geronimo, Gianluigi

2014-11-18

A method and apparatus for pulse pile-up rejection are disclosed. The apparatus comprises a delay value application constituent configured to receive a threshold-crossing time value, and provide an adjustable value according to a delay value and the threshold-crossing time value; and a comparison constituent configured to receive a peak-occurrence time value and the adjustable value, compare the peak-occurrence time value with the adjustable value, indicate pulse acceptance if the peak-occurrence time value is less than or equal to the adjustable value, and indicate pulse rejection if the peak-occurrence time value is greater than the adjustable value.

Data and Time Transfer Using SONET Radio

NASA Technical Reports Server (NTRS)

Graceffo, Gary M.

1996-01-01

The need for precise knowledge of time and frequency has become ubiquitous throughout our society. The areas of astronomy, navigation, and high speed wide-area networks are among a few of the many consumers of this type of information. The Global Positioning System (GPS) has the potential to be the most comprehensive source of precise timing information developed to date; however, the introduction of selective availability has made it difficult for many users to recover this information from the GPS system with the precision required for today's systems. The system described in this paper is a 'Synchronous Optical NetWORK (SONET) Radio Data and Time Transfer System'. The objective of this system is to provide precise time and frequency information to a variety of end-users using a two-way data and time-transfer system. Although time and frequency transfers have been done for many years, this system is unique in that time and frequency information are embedded into existing communications traffic. This eliminates the need to make the transfer of time and frequency informatio a dedicated function of the communications system. For this system SONET has been selected as the transport format from which precise time is derived. SONET has been selected because of its high data rates and its increasing acceptance throughout the industry. This paper details a proof-of-concept initiative to perform embedded time and frequency transfers using SONET Radio.

Low-altitude photographic transects of the Arctic Network of National Park Units and Selawik National Wildlife Refuge, Alaska, July 2013

USGS Publications Warehouse

Marcot, Bruce G.; Jorgenson, M. Torre; DeGange, Anthony R.

2014-01-01

5. A Canon® Rebel 3Ti with a Sigma zoom lens (18–200 mm focal length). The Drift® HD-170 and GoPro® Hero3 cameras were secured to the struts and underwing for nadir (direct downward) imaging. The Panasonic® and Canon® cameras were each hand-held for oblique-angle landscape images, shooting through the airplanes’ windows, targeting both general landscape conditions as well as landscape features of special interest, such as tundra fire scars and landslips. The Drift® and GoPro® cameras each were set for time-lapse photography at 5-second intervals for overlapping coverage. Photographs from all cameras (100 percent .jpg format) were date- and time-synchronized to geographic positioning system waypoints taken during the flights, also at 5-second intervals, providing precise geotagging (latitude-longitude) of all files. All photographs were adjusted for color saturation and gamma, and nadir photographs were corrected for lens distortion for the Drift® and GoPro® cameras’ 170° wide-angle distortion. EXIF (exchangeable image file format) data on camera settings and geotagging were extracted into spreadsheet databases. An additional 1 hour, 20 minutes, and 43 seconds of high-resolution videos were recorded at 60 frames per second with the GoPro® camera along selected transect segments, and also were image-adjusted and corrected for lens distortion. Geotagged locations of 12,395 nadir photographs from the Drift® and GoPro® cameras were overlayed in a geographic information system (ArcMap 10.0) onto a map of 44 ecotypes (land- and water-cover types) of the Arctic Network study area. Presence and area of each ecotype occurring within a geographic information system window centered on the location of each photograph were recorded and included in the spreadsheet databases. All original and adjusted photographs, videos, geographic positioning system flight tracks, and photograph databases are available by contacting ascweb@usgs.gov.

Automatic Locking of Laser Frequency to an Absorption Peak

NASA Technical Reports Server (NTRS)

Koch, Grady J.

2006-01-01

An electronic system adjusts the frequency of a tunable laser, eventually locking the frequency to a peak in the optical absorption spectrum of a gas (or of a Fabry-Perot cavity that has an absorption peak like that of a gas). This system was developed to enable precise locking of the frequency of a laser used in differential absorption LIDAR measurements of trace atmospheric gases. This system also has great commercial potential as a prototype of means for precise control of frequencies of lasers in future dense wavelength-division-multiplexing optical communications systems. The operation of this system is completely automatic: Unlike in the operation of some prior laser-frequency-locking systems, there is ordinarily no need for a human operator to adjust the frequency manually to an initial value close enough to the peak to enable automatic locking to take over. Instead, this system also automatically performs the initial adjustment. The system (see Figure 1) is based on a concept of (1) initially modulating the laser frequency to sweep it through a spectral range that includes the desired absorption peak, (2) determining the derivative of the absorption peak with respect to the laser frequency for use as an error signal, (3) identifying the desired frequency [at the very top (which is also the middle) of the peak] as the frequency where the derivative goes to zero, and (4) thereafter keeping the frequency within a locking range and adjusting the frequency as needed to keep the derivative (the error signal) as close as possible to zero. More specifically, the system utilizes the fact that in addition to a zero crossing at the top of the absorption peak, the error signal also closely approximates a straight line in the vicinity of the zero crossing (see Figure 2). This vicinity is the locking range because the linearity of the error signal in this range makes it useful as a source of feedback for a proportional + integral + derivative control scheme that constantly adjusts the frequency in an effort to drive the error to zero. When the laser frequency deviates from the midpeak value but remains within the locking range, the magnitude and sign of the error signal indicate the amount of detuning and the control circuitry adjusts the frequency by what it estimates to be the negative of this amount in an effort to bring the error to zero.

Two-way sequential time synchronization: Preliminary results from the SIRIO-1 experiment

NASA Technical Reports Server (NTRS)

Detoma, E.; Leschiutta, S.

1981-01-01

A two-way time synchronization experiment performed in the spring of 1979 and 1980 via the Italian SIRIO-1 experimental telecommunications satellite is described. The experiment was designed and implemented to precisely monitor the satellite motion and to evaluate the possibility of performing a high precision, two-way time synchronization using a single communication channel, time-shared between the participating sites. Results show that the precision of the time synchronization is between 1 and 5 ns, while the evaluation and correction of the satellite motion effect was performed with an accuracy of a few nanoseconds or better over a time interval from 1 up to 20 seconds.

High-precision two-dimensional atom localization from four-wave mixing in a double-Λ four-level atomic system

NASA Astrophysics Data System (ADS)

Shui, Tao; Yang, Wen-Xing; Chen, Ai-Xi; Liu, Shaopeng; Li, Ling; Zhu, Zhonghu

2018-03-01

We propose a scheme for high-precision two-dimensional (2D) atom localization via the four-wave mixing (FWM) in a four-level double-Λ atomic system. Due to the position-dependent atom-field interaction, the 2D position information of the atoms can be directly determined by the measurement of the normalized light intensity of output FWM-generated field. We further show that, when the position-dependent generated FWM field has become sufficiently intense, efficient back-coupling to the FWM generating state becomes important. This back-coupling pathway leads to competitive multiphoton destructive interference of the FWM generating state by three supplied and one internally generated fields. We find that the precision of 2D atom localization can be improved significantly by the multiphoton destructive interference and depends sensitively on the frequency detunings and the pump field intensity. Interestingly enough, we show that adjusting the frequency detunings and the pump field intensity can modify significantly the FWM efficiency, and consequently lead to a redistribution of the atoms. As a result, the atom can be localized in one of four quadrants with holding the precision of atom localization.

Development of a 0.5m clear aperture Cassegrain type collimator telescope

NASA Astrophysics Data System (ADS)

Ekinci, Mustafa; Selimoǧlu, Özgür

2016-07-01

Collimator is an optical instrument used to evaluate performance of high precision instruments, especially space-born high resolution telescopes. Optical quality of the collimator telescope needs to be better than the instrument to be measured. This requirement leads collimator telescope to be a very precise instrument with high quality mirrors and a stable structure to keep it operational under specified conditions. In order to achieve precision requirements and to ensure repeatability of the mounts for polishing and metrology, opto-mechanical principles are applied to mirror mounts. Finite Element Method is utilized to simulate gravity effects, integration errors and temperature variations. Finite element analyses results of deformed optical surfaces are imported to optical domain by using Zernike polynomials to evaluate the design against specified WFE requirements. Both mirrors are aspheric and made from Zerodur for its stability and near zero CTE, M1 is further light-weighted. Optical quality measurements of the mirrors are achieved by using custom made CGHs on an interferometric test setup. Spider of the Cassegrain collimator telescope has a flexural adjustment mechanism driven by precise micrometers to overcome tilt errors originating from finite stiffness of the structure and integration errors. Collimator telescope is assembled and alignment methods are proposed.

Proceedings of the Eleventh Annual Precise Time and Time Interval (PTTI) Application and Planning Meeting. [conference

NASA Technical Reports Server (NTRS)

Wardrip, S. C. (Editor)

1979-01-01

Thirty eight papers are presented addressing various aspects of precise time and time interval applications. Areas discussed include: past accomplishments; state of the art systems; new and useful applications, procedures, and techniques; and fruitful directions for research efforts.

Exploring the Use of Molecular Biomarkers for Precision Medicine in Age-Related Macular Degeneration.

PubMed

Lorés-Motta, Laura; de Jong, Eiko K; den Hollander, Anneke I

2018-06-01

Precision medicine aims to improve patient care by adjusting medication to each patient's individual needs. Age-related macular degeneration (AMD) is a heterogeneous eye disease in which several pathways are involved, and the risk factors driving the disease differ per patient. As a consequence, precision medicine holds promise for improved management of this disease, which is nowadays a main cause of vision loss in the elderly. In this review, we provide an overview of the studies that have evaluated the use of molecular biomarkers to predict response to treatment in AMD. We predominantly focus on genetic biomarkers, but also include studies that examined circulating or eye fluid biomarkers in treatment response. This involves studies on treatment response to dietary supplements, response to anti-vascular endothelial growth factor, and response to complement inhibitors. In addition, we highlight promising new therapies that have been or are currently being tested in clinical trials and discuss the molecular studies that can help identify the most suitable patients for these upcoming therapeutic approaches.

Supersensitive ancilla-based adaptive quantum phase estimation

NASA Astrophysics Data System (ADS)

Larson, Walker; Saleh, Bahaa E. A.

2017-10-01

The supersensitivity attained in quantum phase estimation is known to be compromised in the presence of decoherence. This is particularly patent at blind spots—phase values at which sensitivity is totally lost. One remedy is to use a precisely known reference phase to shift the operation point to a less vulnerable phase value. Since this is not always feasible, we present here an alternative approach based on combining the probe with an ancillary degree of freedom containing adjustable parameters to create an entangled quantum state of higher dimension. We validate this concept by simulating a configuration of a Mach-Zehnder interferometer with a two-photon probe and a polarization ancilla of adjustable parameters, entangled at a polarizing beam splitter. At the interferometer output, the photons are measured after an adjustable unitary transformation in the polarization subspace. Through calculation of the Fisher information and simulation of an estimation procedure, we show that optimizing the adjustable polarization parameters using an adaptive measurement process provides globally supersensitive unbiased phase estimates for a range of decoherence levels, without prior information or a reference phase.

LACIS-T - A moist air wind tunnel for investigating the interactions between cloud microphysics and turbulence

NASA Astrophysics Data System (ADS)

Niedermeier, Dennis; Voigtländer, Jens; Siebert, Holger; Desai, Neel; Shaw, Raymond; Chang, Kelken; Krueger, Steven; Schumacher, Jörg; Stratmann, Frank

2017-11-01

Turbulence - cloud droplet interaction processes have been investigated primarily through numerical simulation and field measurements over the last ten years. However, only in the laboratory we can be confident in our knowledge of initial and boundary conditions, and are able to measure for extended times under statistically stationary and repeatable conditions. Therefore, the newly built turbulent wind tunnel LACIS-T (Turbulent Leipzig Aerosol Cloud Interaction Simulator) is an ideal facility for pursuing mechanistic understanding of these processes. Within the tunnel we are able to adjust precisely controlled turbulent temperature and humidity fields so as to achieve supersaturation levels allowing for detailed investigations of the interactions between cloud microphysical processes (e.g., cloud droplet activation) and the turbulent flow, under well-defined and reproducible laboratory conditions. We will present the fundamental operating principle, first results from ongoing characterization efforts, numerical simulations as well as first droplet activation experiments.

Design of high-speed burst mode clock and data recovery IC for passive optical network

NASA Astrophysics Data System (ADS)

Yan, Minhui; Hong, Xiaobin; Huang, Wei-Ping; Hong, Jin

2005-09-01

Design of a high bit rate burst mode clock and data recovery (BMCDR) circuit for gigabit passive optical networks (GPON) is described. A top-down design flow is established and some of the key issues related to the behavioural level modeling are addressed in consideration for the complexity of the BMCDR integrated circuit (IC). Precise implementation of Simulink behavioural model accounting for the saturation of frequency control voltage is therefore developed for the BMCDR, and the parameters of the circuit blocks can be readily adjusted and optimized based on the behavioural model. The newly designed BMCDR utilizes the 0.18um standard CMOS technology and is shown to be capable of operating at bit rate of 2.5Gbps, as well as the recovery time of one bit period in our simulation. The developed behaviour model is verified by comparing with the detailed circuit simulation.

Digital EPR with an arbitrary waveform generator and direct detection at the carrier frequency

PubMed Central

Tseitlin, Mark; Quine, Richard W.; Rinard, George A.; Eaton, Sandra S.; Eaton, Gareth R.

2011-01-01

A digital EPR spectrometer was constructed by replacing the traditional bridge with an arbitrary waveform generator (AWG) to produce excitation patterns and a high-speed digitizer for direct detection of the spin system response at the carrier frequency. Digital down-conversion produced baseband signals in quadrature with very precise orthogonality. Real-time resonator tuning was performed by monitoring the Fourier transforms of signals reflected from the resonator during frequency sweeps generated by the AWG. The capabilities of the system were demonstrated by rapid magnetic field scans at 256 MHz carrier frequency, and FID and spin echo experiments at 1 and 10 GHz carrier frequencies. For the rapid scan experiments the leakage through a cross-loop resonator was compensated by adjusting the amplitude and phase of a sinusoid at the carrier frequency that was generated with another AWG channel. PMID:21968420

Crew exploration vehicle (CEV) attitude control using a neural-immunology/memory network

NASA Astrophysics Data System (ADS)

Weng, Liguo; Xia, Min; Wang, Wei; Liu, Qingshan

2015-01-01

This paper addresses the problem of the crew exploration vehicle (CEV) attitude control. CEVs are NASA's next-generation human spaceflight vehicles, and they use reaction control system (RCS) jet engines for attitude adjustment, which calls for control algorithms for firing the small propulsion engines mounted on vehicles. In this work, the resultant CEV dynamics combines both actuation and attitude dynamics. Therefore, it is highly nonlinear and even coupled with significant uncertainties. To cope with this situation, a neural-immunology/memory network is proposed. It is inspired by the human memory and immune systems. The control network does not rely on precise system dynamics information. Furthermore, the overall control scheme has a simple structure and demands much less computation as compared with most existing methods, making it attractive for real-time implementation. The effectiveness of this approach is also verified via simulation.

Modeling of high-precision wavefront sensing with new generation of CMT avalanche photodiode infrared detectors.

PubMed

Gousset, Silvère; Petit, Cyril; Michau, Vincent; Fusco, Thierry; Robert, Clelia

2015-12-01

Near-infrared wavefront sensing allows for the enhancement of sky coverage with adaptive optics. The recently developed HgCdTe avalanche photodiode arrays are promising due to their very low detector noise, but still present an imperfect cosmetic that may directly impact real-time wavefront measurements for adaptive optics and thus degrade performance in astronomical applications. We propose here a model of a Shack-Hartmann wavefront measurement in the presence of residual fixed pattern noise and defective pixels. To adjust our models, a fine characterization of such an HgCdTe array, the RAPID sensor, is proposed. The impact of the cosmetic defects on the Shack-Hartmann measurement is assessed through numerical simulations. This study provides both a new insight on the applicability of cadmium mercury telluride (CMT) avalanche photodiodes detectors for astronomical applications and criteria to specify the cosmetic qualities of future arrays.

Arbitrary-shaped Brillouin microwave photonic filter by manipulating a directly modulated pump.

PubMed

Wei, Wei; Yi, Lilin; Jaouën, Yves; Hu, Weisheng

2017-10-15

We present a cost-effective gigahertz-wide arbitrary-shaped microwave photonic filter based on stimulated Brillouin scattering in fiber using a directly modulated laser (DML). After analyzing the relationship between the spectral power density and the modulation current of the DML, we manage to precisely adjust the optical spectrum of the DML, thereby controlling the Brillouin filter response arbitrarily for the first time, to the best of our knowledge. The filter performance is evaluated by amplifying a 500 Mb/s non-return-to-zero on-off keying signal using a 1 GHz rectangular filter. The comparison between the proposed DML approach and the previous approach adopting a complex IQ modulator shows similar filter flexibility, shape fidelity, and noise performance, proving that the DML-based Brillouin filter technique is a cost-effective and valid solution for microwave photonic applications.

Automatic Match between Delimitation Line and Real Terrain Based on Least-Cost Path Analysis

NASA Astrophysics Data System (ADS)

Feng, C. Q.; Jiang, N.; Zhang, X. N.; Ma, J.

2013-11-01

Nowadays, during the international negotiation on separating dispute areas, manual adjusting is lonely applied to the match between delimitation line and real terrain, which not only consumes much time and great labor force, but also cannot ensure high precision. Concerning that, the paper mainly explores automatic match between them and study its general solution based on Least -Cost Path Analysis. First, under the guidelines of delimitation laws, the cost layer is acquired through special disposals of delimitation line and terrain features line. Second, a new delimitation line gets constructed with the help of Least-Cost Path Analysis. Third, the whole automatic match model is built via Module Builder in order to share and reuse it. Finally, the result of automatic match is analyzed from many different aspects, including delimitation laws, two-sided benefits and so on. Consequently, a conclusion is made that the method of automatic match is feasible and effective.

Modeling a photoinduced planar-to-homeotropic anchoring transition triggered by surface azobenzene units in a nematic liquid crystal

NASA Astrophysics Data System (ADS)

Oswald, Patrick; Ignés-Mullol, Jordi

2017-09-01

The performance of light-controlled liquid crystal anchoring surfaces depends on the nature of the photosensitive moieties and on the concentration of spacer units. Here, we study the kinetics of photosensitive liquid crystal cells that incorporate an azobenzene-based self-assembled monolayer. We characterize the photoinduced homeotropic-to-planar transition and the subsequent reverse relaxation in terms of the underlying isomerization of the photosensitive layer. We show that the response time can be precisely adjusted by tuning the lateral packing of azobenzene units by means of inert spacer molecules. Using simple kinetic assumptions and a well-known model for the energetics of liquid crystal anchoring we are able to capture the details of the optical microscopy experimental observations. Our analysis provides fitted values for all the relevant material parameters, including the zenithal and the azimuthal anchoring strength.

A high sensitive 66 dB linear dynamic range receiver for 3-D laser radar

NASA Astrophysics Data System (ADS)

Ma, Rui; Zheng, Hao; Zhu, Zhangming

2017-08-01

This study presents a CMOS receiver chip realized in 0.18 μm standard CMOS technology and intended for high precision 3-D laser radar. The chip includes an adjustable gain transimpedance pre-amplifier, a post-amplifier and two timing comparators. An additional feedback is employed in the regulated cascode transimpedance amplifier to decrease the input impedance, and a variable gain transimpedance amplifier controlled by digital switches and analog multiplexer is utilized to realize four gain modes, extending the input dynamic range. The measurement shows that the highest transimpedance of the channel is 50 k {{Ω }}, the uncompensated walk error is 1.44 ns in a wide linear dynamic range of 66 dB (1:2000), and the input referred noise current is 2.3 pA/\\sqrt{{Hz}} (rms), resulting in a very low detectable input current of 1 μA with SNR = 5.

Dynamics of copper-phthalocyanine molecules on Au/Ge(001).

PubMed

Sotthewes, K; Heimbuch, R; Zandvliet, H J W

2015-10-07

Spatially resolved current-time scanning tunneling spectroscopy combined with current-distance spectroscopy has been used to characterize the dynamic behavior of copper-phthalocyanine (CuPc) molecules adsorbed on a Au-modified Ge(001) surface. The analyzed CuPc molecules are adsorbed in a "molecular bridge" configuration, where two benzopyrrole groups (lobes) are connected to a Au-induced nanowire, whereas the other two lobes are connected to the adjacent nanowire. Three types of lobe configurations are found: a bright lobe, a dim lobe, and a fuzzy lobe. The dim and fuzzy lobes exhibit a well-defined switching behavior between two discrete levels, while the bright lobe shows a broad oscillation band. The observed dynamic behavior is induced by electrons that are injected into the LUMO+1 orbital of the CuPc molecule. By precisely adjusting the tip-molecule distance, the switching frequency of the lobes can be tuned accurately.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Taguchi, Atsushi; Saito, Yuika; Watanabe, Koichi

Localized surface plasmon resonances were controlled at deep-ultraviolet (DUV) wavelengths by fabricating aluminum (Al) nanostructures in a size-controllable manner. Plasmon resonances were obtained at wavelengths from near-UV down to 270 nm (4.6 eV) depending on the fabricated structure size. Such precise size control was realized by the nanosphere lithography technique combined with additional microwave heating to shrink the spaces in a close-packed monolayer of colloidal nanosphere masks. By adjusting the microwave heating time, the sizes of the Al nanostructures could be controlled from 80 nm to 50 nm without the need to use nanosphere beads of different sizes. With themore » outstanding controllability and versatility of the presented fabrication technique, the fabricated Al nanostructure is promising for use as a DUV plasmonic substrate, a light-harvesting platform for mediating strong light-matter interactions between UV photons and molecules placed near the metal nanostructure.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deane, M.; Swan, S.H.; Harris, J.A.

An epidemiologic study was conducted to investigate a suspected cluster of adverse outcomes of pregnancies conceived in 1980-1981 among women who resided in a census tract in Santa Clara County, California that was thought to be exposed to drinking water from a well contaminated by an organic solvent, trichloroethane. A comparison census tract that received water from a different source was selected on the basis of demographic comparability. The cluster was confirmed; the odds ratio for spontaneous abortion was 2.3 (95% confidence interval (Cl) 1.3-4.2) after adjustment by multiple logistic regression for maternal risk factors, including maternal age, alcohol consumption,more » smoking, and prior fetal loss. The relative risk for congenital malformations was 3.1 (95% Cl 1.1-10.4). Because of the lack of precise information on the timing and extent of contamination, the pattern of spontaneous abortion rates throughout the study period cannot be used to either support or refute a causal inference.« less

Dynamics of copper-phthalocyanine molecules on Au/Ge(001)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sotthewes, K.; Heimbuch, R.; Zandvliet, H. J. W.

2015-10-07

Spatially resolved current-time scanning tunneling spectroscopy combined with current-distance spectroscopy has been used to characterize the dynamic behavior of copper-phthalocyanine (CuPc) molecules adsorbed on a Au-modified Ge(001) surface. The analyzed CuPc molecules are adsorbed in a “molecular bridge” configuration, where two benzopyrrole groups (lobes) are connected to a Au-induced nanowire, whereas the other two lobes are connected to the adjacent nanowire. Three types of lobe configurations are found: a bright lobe, a dim lobe, and a fuzzy lobe. The dim and fuzzy lobes exhibit a well-defined switching behavior between two discrete levels, while the bright lobe shows a broad oscillationmore » band. The observed dynamic behavior is induced by electrons that are injected into the LUMO+1 orbital of the CuPc molecule. By precisely adjusting the tip-molecule distance, the switching frequency of the lobes can be tuned accurately.« less

P dopants induced ferromagnetism in g-C3N4 nanosheets: Experiments and calculations

NASA Astrophysics Data System (ADS)

Liu, Yonggang; Liu, Peitao; Sun, Changqi; Wang, Tongtong; Tao, Kun; Gao, Daqiang

2017-05-01

Outstanding magnetic properties are highly desired for two-dimensional (2D) semiconductor nanosheets due to their potential applications in spintronics. Metal-free ferromagnetic 2D materials whose magnetism originated from the pure s/p electron configuration could give a long spin relaxation time, which plays the vital role in spin information transfer. Here, we synthesize 2D g-C3N4 nanosheets with room temperature ferromagnetism induced by P doping. In our case, the Curie temperature of P doped g-C3N4 nanosheets reaches as high as 911 K and the precise control of the P concentration can further adjust the saturation magnetization of the samples. First principles calculation results indicate that the magnetic moment is primarily due to strong hybridization between p bonds of P, N, and C atoms, giving the theoretical evidence of the ferromagnetism. This work opens another door to engineer a future generation of spintronic devices.

Enhancing user experience by using multi-sensor data fusion to predict phone's luminance

NASA Astrophysics Data System (ADS)

Marhoubi, Asmaa H.

2017-09-01

The movement of a phone in an environment with different brightness, makes the luminance prediction challenging. The ambient light sensor takes time to modify the brightness of the screen based on the environment it is placed in. This causes an unsatisfactory user experience and delays in adjustment of the screen brightness. In this research, a method is proposed for enhancing the prediction of luminance using accelerometer, gyroscope and speed measurement technique. The speed of the phone is identified using Sum-of-Sine parameters. The lux values are then fused with the accelerometer and gyroscope data to present more accurate luminance values for the ALS based on the movement of the phone. An investigation is made during the movement of the user in a standard lighting environment. This enhances the user experience and improves the screen brightness precision. The accuracy has given an R-Square value of up to 0.97.

Control system of water flow and casting speed in continuous steel casting

NASA Astrophysics Data System (ADS)

Tirian, G. O.; Gheorghiu, C. A.; Hepuţ, T.; Chioncel, C.

2017-05-01

This paper presents the results of research based on real data taken from the installation process at Arcelor Mittal Hunedoara. Using Matlab Simulink an intelligent system is made that takes in data from the process and makes real time adjustments in the rate of flow of the cooling water and the speed of casting that eliminates fissures in the poured material from the secondary cooling of steel. Using Matlab Simulink simulation environment allowed for qualitative analysis for various real world situations. Thus, compared to the old method of approach for the problem of cracks forming in the crust of the steel in the continuous casting, this new method, proposed and developed, brings safety and precision in this complex process, thus removing any doubt on the existence or non-existence of cracks and takes the necessary steps to prevent and correct them.

Analytical minimization of synchronicity errors in stochastic identification

NASA Astrophysics Data System (ADS)

Bernal, D.

2018-01-01

An approach to minimize error due to synchronicity faults in stochastic system identification is presented. The scheme is based on shifting the time domain signals so the phases of the fundamental eigenvector estimated from the spectral density are zero. A threshold on the mean of the amplitude-weighted absolute value of these phases, above which signal shifting is deemed justified, is derived and found to be proportional to the first mode damping ratio. It is shown that synchronicity faults do not map precisely to phasor multiplications in subspace identification and that the accuracy of spectral density estimated eigenvectors, for inputs with arbitrary spectral density, decrease with increasing mode number. Selection of a corrective strategy based on signal alignment, instead of eigenvector adjustment using phasors, is shown to be the product of the foregoing observations. Simulations that include noise and non-classical damping suggest that the scheme can provide sufficient accuracy to be of practical value.

Proceedings of the Sixteenth Annual Precise Time and Time Interval (PTTI) Applications and Planning Meeting

NASA Technical Reports Server (NTRS)

1984-01-01

The effects of ionospheric and tropospheric propagation on time and frequency transfer, advances in the generation of precise time and frequency, time transfer techniques and filtering and modeling were among the topics emphasized. Rubidium and cesium frequency standard, crystal oscillators, masers, Kalman filters, and atomic clocks were discussed.

Study on Dynamic Alignment Technology of COIL Resonator

NASA Astrophysics Data System (ADS)

Xiong, M. D.; Zou, X. J.; Guo, J. H.; Jia, S. N.; Zhang2, Z. B.

2006-10-01

The performance of great power chemical oxygen-iodine laser (COIL) beam is decided mostly by resonator mirror maladjustment and environment vibration. To improve the performance of light beam, an auto-alignment device is used in COIL resonator, the device can keep COIL resonator collimating by adjusting the optical components of resonator. So the coupling model of COIL resonator is present. The multivariable self study fuzzy uncoupling arithmetic and six-dimensional micro drive technology are used to design a six-input-three-output uncoupling controller, resulting in the realization of the high precision dynamic alignment. The experiments indicate that the collimating range of this system is 8 mrad, precision is 5 urad and frequency response is 20Hz, which meet the demand of resonator alignment system.

Kalman Filter for Mass Property and Thrust Identification (MMS)

NASA Technical Reports Server (NTRS)

Queen, Steven

2015-01-01

The Magnetospheric Multiscale (MMS) mission consists of four identically instrumented, spin-stabilized observatories, elliptically orbiting the Earth in a tetrahedron formation. For the operational success of the mission, on-board systems must be able to deliver high-precision orbital adjustment maneuvers. On MMS, this is accomplished using feedback from on-board star sensors in tandem with accelerometers whose measurements are dynamically corrected for errors associated with a spinning platform. In order to determine the required corrections to the measured acceleration, precise estimates of attitude, rate, and mass-properties is necessary. To this end, both an on-board and ground-based Multiplicative Extended Kalman Filter (MEKF) were formulated and implemented in order to estimate the dynamic and quasi-static properties of the spacecraft.

Three-dimensional precise orientation of bilateral auricular trial prosthesis using a facebow for a young adult with Crouzon syndrome

PubMed Central

Rathee, Manu; Tamrakar, Amit Kumar; Kundu, Renu; Yunus, Nadeem

2014-01-01

Facial deformity can be debilitating, especially in the psychological and cosmetic aspects. Although surgical correction or replacement of deformed or missing parts is the ideal treatment, prosthetic replacement serves the purpose in case of surgical limitations. Prosthetic rehabilitation of a missing auricle is an acceptable option as it provides better control over the tortuous anatomical shape and shade of the missing portion. Improper spatial orientation of the prosthetic ear on the face can damage the results of even the most aesthetic prosthesis. This case report describes a simple and innovative method for precise spatial orientation of auricular trial prosthesis using a facebow and custom-made adjustable mechanical retention design using stainless steel wire. PMID:25096652

Precision mechanisms for optics in a vacuum cryogenic environment

NASA Astrophysics Data System (ADS)

Navarro, R.; Elswijk, E.; Tromp, N.; Kragt, J.; Kroes, G.; Hanenburg, H.; de Haan, M.; Schuil, M.; Teuwen, M.; Janssen, H.; Venema, L.

2017-11-01

To achieve superb stability in cryogenic optical systems, NOVA-ASTRON generally designs optical instruments on the basis of a 'no adjustments' philosophy. This means that in principle no corrections are possible after assembly. The alignment precision and consequently the performance of the instrument is guaranteed from the design, the tolerance analysis and the detailed knowledge of the material behavior and manufacturing process. This resulted in a higher degree of integrated optomechanical-cryogenic design with fewer parts, but with a higher part complexity. The 'no adjustments' strategy is successful because in the end the risk on instrument performance and project delays is much reduced. Astronomical instrument specifications have become more challenging over the years. Recent designs of the European Southern Observatory Very Large Telescope Interferometer (ESO VLTI) 4 Telescope combiner MATISSE include hundreds of optical components in a cryogenic environment. Despite the large number of optical components the alignment accuracy and stability requirements are in the order of nanometers. The 'no adjustments' philosophy would be too costly in this case, because all components would need to meet extremely tight manufacturing specifications. These specifications can be relaxed dramatically if cryogenic mechanisms are used for alignment. Several mechanisms have been developed: a tip-tilt mirror mechanism, an optical path distance mechanism, a slider mechanism, a bistable cryogenic shutter and a mirror mounting clip. Key aspects of these mechanisms are that the optical element and mechanism are combined in a compact single component, driven by e.g. self braking piezo actuators in order to hold position without power. The design, realization and test results of several mechanisms are presented in this paper.

Robust adaptive extended Kalman filtering for real time MR-thermometry guided HIFU interventions.

PubMed

Roujol, Sébastien; de Senneville, Baudouin Denis; Hey, Silke; Moonen, Chrit; Ries, Mario

2012-03-01

Real time magnetic resonance (MR) thermometry is gaining clinical importance for monitoring and guiding high intensity focused ultrasound (HIFU) ablations of tumorous tissue. The temperature information can be employed to adjust the position and the power of the HIFU system in real time and to determine the therapy endpoint. The requirement to resolve both physiological motion of mobile organs and the rapid temperature variations induced by state-of-the-art high-power HIFU systems require fast MRI-acquisition schemes, which are generally hampered by low signal-to-noise ratios (SNRs). This directly limits the precision of real time MR-thermometry and thus in many cases the feasibility of sophisticated control algorithms. To overcome these limitations, temporal filtering of the temperature has been suggested in the past, which has generally an adverse impact on the accuracy and latency of the filtered data. Here, we propose a novel filter that aims to improve the precision of MR-thermometry while monitoring and adapting its impact on the accuracy. For this, an adaptive extended Kalman filter using a model describing the heat transfer for acoustic heating in biological tissues was employed together with an additional outlier rejection to address the problem of sparse artifacted temperature points. The filter was compared to an efficient matched FIR filter and outperformed the latter in all tested cases. The filter was first evaluated on simulated data and provided in the worst case (with an approximate configuration of the model) a substantial improvement of the accuracy by a factor 3 and 15 during heat up and cool down periods, respectively. The robustness of the filter was then evaluated during HIFU experiments on a phantom and in vivo in porcine kidney. The presence of strong temperature artifacts did not affect the thermal dose measurement using our filter whereas a high measurement variation of 70% was observed with the FIR filter.

Anticipatory scaling of grip forces when lifting objects of everyday life.

PubMed

Hermsdörfer, Joachim; Li, Yong; Randerath, Jennifer; Goldenberg, Georg; Eidenmüller, Sandra

2011-07-01

The ability to predict and anticipate the mechanical demands of the environment promotes smooth and skillful motor actions. Thus, the finger forces produced to grasp and lift an object are scaled to the physical properties such as weight. While grip force scaling is well established for neutral objects, only few studies analyzed objects known from daily routine and none studied grip forces. In the present study, eleven healthy subjects each lifted twelve objects of everyday life that encompassed a wide range of weights. The finger pads were covered with force sensors that enabled the measurement of grip force. A scale registered load forces. In a control experiment, the objects were wrapped into paper to prevent recognition by the subjects. Data from the first lift of each object confirmed that object weight was anticipated by adequately scaled forces. The maximum grip force rate during the force increase phase emerged as the most reliable measure to verify that weight was actually predicted and to characterize the precision of this prediction, while other force measures were scaled to object weight also when object identity was not known. Variability and linearity of the grip force-weight relationship improved for time points reached after liftoff, suggesting that sensory information refined the force adjustment. The same mechanism seemed to be involved with unrecognizable objects, though a lower precision was reached. Repeated lifting of the same object within a second and third presentation block did not improve the precision of the grip force scaling. Either practice was too variable or the motor system does not prioritize the optimization of the internal representation when objects are highly familiar.

Factors controlling precision and accuracy in isotope-ratio-monitoring mass spectrometry

NASA Technical Reports Server (NTRS)

Merritt, D. A.; Hayes, J. M.

1994-01-01

The performance of systems in which picomole quantities of sample are mixed with a carrier gas and passed through an isotope-ratio mass spectrometer system was examined experimentally and theoretically. Two different mass spectrometers were used, both having electron-impact ion sources and Faraday cup collector systems. One had an accelerating potential of 10kV and accepted 0.2 mL of He/min, producing, under those conditions, a maximum efficiency of 1 CO2 molecular ion collected per 700 molecules introduced. Comparable figures for the second instrument were 3 kV, 0.5 mL of He/min, and 14000 molecules/ion. Signal pathways were adjusted so that response times were <200 ms. Sample-related ion currents appeared as peaks with widths of 3-30 s. Isotope ratios were determined by comparison to signals produced by standard gases. In spite of rapid variations in signals, observed levels of performance were within a factor of 2 of shot-noise limits. For the 10-kV instrument, sample requirements for standard deviations of 0.1 and 0.5% were 45 and 1.7 pmol, respectively. Comparable requirements for the 3-kV instrument were 900 and 36 pmol. Drifts in instrumental characteristics were adequately neutralized when standards were observed at 20-min intervals. For the 10-kV instrument, computed isotopic compositions were independent of sample size and signal strength over the ranges examined. Nonlinearities of <0.04%/V were observed for the 3-kV system. Procedures for observation and subtraction of background ion currents were examined experimentally and theoretically. For sample/ background ratios varying from >10 to 0.3, precision is expected and observed to decrease approximately 2-fold and to depend only weakly on the precision with which background ion currents have been measured.

Pressure filtration of ceramic pastes. 4: Treatment of experimental data

NASA Technical Reports Server (NTRS)

Torrecillas, A. S.; Polo, J. F.; Perez, A. A.

1984-01-01

The use of data processing method based on the algorithm proposed by Kalman and its application to the filtration process at constant pressure are described, as well as the advantages of this method. This technique is compared to the least squares method. The operation allows the precise parameter adjustment of the equation in direct relationship to the specific resistance of the cake.

Simplified Rotation In Acoustic Levitation

NASA Technical Reports Server (NTRS)

Barmatz, M. B.; Gaspar, M. S.; Trinh, E. H.

1989-01-01

New technique based on old discovery used to control orientation of object levitated acoustically in axisymmetric chamber. Method does not require expensive equipment like additional acoustic drivers of precisely adjustable amplitude, phase, and frequency. Reflecting object acts as second source of sound. If reflecting object large enough, close enough to levitated object, or focuses reflected sound sufficiently, Rayleigh torque exerted on levitated object by reflected sound controls orientation of object.

The crush and spray: a patented design for herbicide application with less waste

Treesearch

Cherie LeBlanc Fisher; Adam H. Wiese

2009-01-01

The USDA Forest Service recently patented an equipment design to deliver herbicides more efficiently and cost-effectively. Towed by a standard all-terrain vehicle, the Crush and Spray can access out-of-the-way or wet locations. An adjustable roller first knocks down the unwanted plants. A low-set spray boom with wide angle sprayer nozzles then provides precise, close-...