Science.gov

Sample records for preliminary lta pie

  1. Lea's Pies

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The Technology Transfer Office at Stennis Space Center worked with a pie company owner to develop an inexpensive container that would protect pies and keep them in a near frozen condition for shipping in 48 hours. A NASA engineer made a thermal barrier envelope from a metalized mylar called 'space blanket material,' developed during the Apollo era. The envelope protects the pies from heat transfer. Pictured, a NASA engineer removes the temperature logger from a pecan pie shipped to him in a prototype envelope.

  2. LTA Physics Design: Description of All MOX Pin LTA Design

    SciTech Connect

    Pavlovichev, A.M.

    2001-09-28

    In this document issued according to Work Release 02. P. 99-lb the results of neutronics studies of <<100%Pu>> MOX LTA design are presented. The parametric studies of infinite MOX-UOX grids, MOX-UOX core fragments and of VVER-1000 core with 3 MOX LTAs are performed. The neutronics parameters of MOX fueled core have been performed for the chosen design MOX LTA using the Russian 3D code BIPR-7A and 2D code PERMAK-A with the constants prepared by the cell spectrum code TVS-M.

  3. LTA structures and materials technology

    NASA Technical Reports Server (NTRS)

    Mayer, N. J.

    1975-01-01

    The state-of-the-art concerning structures and materials technology is reviewed. It is shown that many present materials developments resulting from balloon and aircraft research programs can be applied to new concepts in LTA vehicles. Both buoyant and semi-buoyant vehicles utilize similar approaches to solving structural problems and could involve pressurized non-rigid and unpressurized rigid structures. System designs common to both and vital to structural integrity include much of the past technology as well. Further research is needed in determination of structural loads, especially in future design concepts.

  4. Multi-PIE.

    PubMed

    Gross, Ralph; Matthews, Iain; Cohn, Jeff; Kanade, Takeo; Baker, Simon

    2010-05-01

    A close relationship exists between the advancement of face recognition algorithms and the availability of face databases varying factors that affect facial appearance in a controlled manner. The CMU PIE database has been very influential in advancing research in face recognition across pose and illumination. Despite its success the PIE database has several shortcomings: a limited number of subjects, single recording session and only few expressions captured. To address these issues we collected the CMU Multi-PIE database. It contains 337 subjects, imaged under 15 view points and 19 illumination conditions in up to four recording sessions. In this paper we introduce the database and describe the recording procedure. We furthermore present results from baseline experiments using PCA and LDA classifiers to highlight similarities and differences between PIE and Multi-PIE.

  5. 1981 LTA technology assessment - Past and present

    NASA Technical Reports Server (NTRS)

    Ashford, R. L.; Levitt, B. B.; Mayer, N. J.; Vocar, J. M.; Woodward, D. E.

    1981-01-01

    A four-part presentation is made of (1) lessons learned from the design and operation of the 'classic' airships of the 1920s and 30s, with respect to such issues as construction, propulsion, control, instrumentation, ground handling, habitability, aerodynamics, and structure and construction; (2) lessons learned from the development of such specialized lighter-than-air (LTA) concepts as metal-clad airships, semi-buoyant lifting bodies, experimental, sport and commercial free balloons, high-altitude platforms, and tethered aerostats; (3) the current status of LTA technology in various countries, with emphasis on significant developments in configuration, dynamics, control, structures, materials, and propulsion; and (4) a projection of future trends. It is concluded that socio-economic factors will strongly influence and encourage LTA development in the 1990s.

  6. Aerial view of entire LTA base after completion of both ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Aerial view of entire LTA base after completion of both LTA ship hangars. Date unknown but probably circa 1945. - Marine Corps Air Station Tustin, Northern Lighter Than Air Ship Hangar, Meffett Avenue & Maxfield Street, Tustin, Orange County, CA

  7. LTA measurements on shuttle cleaning nozzle

    NASA Technical Reports Server (NTRS)

    1995-01-01

    A laser transit anemometer was used to make flow field velocity measurements on a supersonic air/water cleaning nozzle used to clean liquid oxygen shuttle components at Kennedy Space Center. The velocity along the centerline of the nozzle was characterized by the LTA system and compared with CFD calculations to ascertain the optimum distance the nozzle should be placed from the liquid oxygen part for maximum cleaning..

  8. LTA structures and materials technology. [airships

    NASA Technical Reports Server (NTRS)

    Mayer, N. J.

    1975-01-01

    The state-of-the-art concerning structures and materials technology is reviewed. It is shown that many present materials developments resulting from balloon and aircraft research programs can be applied to new concepts in LTA vehicles. Both buoyant and semi-buoyant vehicles will utilize similar approaches to solving structural problems and could involve pressurized non-rigid and unpressurized rigid structures. System designs common to both and vital to structural integrity will include much of the past technology as well. Further research is needed in determination of structural loads, especially in future design concepts.

  9. LTA - Recent developments. [Lighter Than Air ships

    NASA Technical Reports Server (NTRS)

    Mayer, N. J.

    1977-01-01

    NASA-sponsored studies of existing and new LTA missions showed that airships looked very promising for some two dozen civil and military applications. These include surveillance of rural and urban areas, in the form of forest and police patrols; transport of very heavy large-volume maritime, industrial, and military payloads; coastal patrol and sea control; seismographic surveys; air pollution monitoring; and moving goods to remote areas; along with a number of less important but still attractive missions. A figure of merit of productivity (payload weight, ton moles per hour) was used to compare airships of various type and size. In each case, this criterion established an index of efficiency for evaluating not only conceptual approaches but also modes of flight. Some, in part unexpected, results of these studies are described.

  10. Aerial view of construction of both LTA ship hangars (looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Aerial view of construction of both LTA ship hangars (looking north) circa 1942. - Marine Corps Air Station Tustin, Northern Lighter Than Air Ship Hangar, Meffett Avenue & Maxfield Street, Tustin, Orange County, CA

  11. Aerial view of reroofing of northern LTA ship hangar, circa ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Aerial view of re-roofing of northern LTA ship hangar, circa 1957. - Marine Corps Air Station Tustin, Northern Lighter Than Air Ship Hangar, Meffett Avenue & Maxfield Street, Tustin, Orange County, CA

  12. Stovetop Earth Pecan Pie

    NASA Astrophysics Data System (ADS)

    Robin, C. M.

    2005-12-01

    Many fluid mechanical experiments with direct applications to Earth Science are performed with sugary syrups using conceptually straightforward procedures. Corn syrup has indeed proven to be a godsend for those studying convection and related non-linear phenomena. In addition, however, it gives experimentalists a deep physical intuition for the interior workings of hot planets. The basic concepts behind plate tectonics and mantle convection are not difficult; indeed, although they may not be aware of it, most students probably have a basic intuitive understanding of fluid mechanics gained in their daily life. However, the large size and long time scale of geophysical processes may be quite intimidating to young students. Even a simple geophysical experiment requires a complicated array of coolers, heaters and measuring and recording equipment. It is of interest to introduce students to the geodynamical concepts that can be visualized in a high-tech lab using familiar processes and equipment. Using a homemade apparatus and grocery store supplies, I propose using a 'Stove-top Earth pecan pie' to introduce simple geodynamic concepts to middle- and high-school students. The initially cold syrup heats up and the pecans begin to float (continent formation), the syrup begins to convect (mantle convection), and convection slows down after the heat is removed (secular cooling). Even Wilson cycles can be simulated by moving the pan to one side or the other of the stovetop or heating element. The activity formally introduces students to convection and its application to the earth, and makes them think about plate motion, heat transfer, scaling, and experimental procedures. As an added bonus, they can eat their experiments after recess!

  13. Airships 101: Rediscovering the Potential of Lighter-Than-Air (LTA)

    NASA Technical Reports Server (NTRS)

    Melton, John E.; Hochstetler, Ronald D.

    2012-01-01

    An overview of airships past, present, and future is provided in a Powerpoint-formatted presentation. This presentation was requested for transfer to the British MOD by Paul Espinosa of NASA Ames, Code PX. The presentation provides general information about airships divided into four main categories: the legacy of NASA Ames in LTA (Lighter-Than-Air), LTA taxonomy and theory, LTA revival and missions, and LTA research and technology.

  14. The PIE Institute Project: Final Evaluation Report

    ERIC Educational Resources Information Center

    St. John, Mark; Carroll, Becky; Helms, Jen; Smith, Anita

    2008-01-01

    The Playful Invention and Exploration (PIE) Institute project was funded in 2005 by the National Science Foundation (NSF). For the past three years, Inverness Research has served as the external evaluator for the PIE project. The authors' evaluation efforts have included extensive observation and documentation of PIE project activities; ongoing…

  15. [Pie]: Re-Count and Recall

    ERIC Educational Resources Information Center

    Scott, Paul

    2008-01-01

    The number [pie] [approximately] 3.14159 is defined to be the ratio C/d of the circumference C to the diameter d of any given circle. In this article, the author looks at some surprising and unexpected places where [pie] occurs, and then thinks about some ways of remembering all those digits in the expansion of [pie].

  16. Phase selection controlled by sodium ions in the synthesis of FAU/LTA composite zeolite

    PubMed Central

    Hu, Linyan; Xie, Sujuan; Wang, Qingxia; Liu, Shenglin; Xu, Longya

    2009-01-01

    Zeolite faujasite (FAU), Linde type A (LTA) and FAU/LTA composite have been synthesized using tetramethylammonium cation (TMA+) as template, by adjusting only the concentration of Na+ ions in the initial solution (1.00 Al2O3 4.36 SiO2 : 2.39 (TMA)2 O : β Na2 O : 249.00H2 O). Na+ ions alter the phase composition of the product more than TMA+ or OH− ions. When Na2 O concentration [Na2 O] increases from 0.024 to 0.168, the product gradually changes from pure FAU to pure LTA via the formation of FAU/LTA composite with increasing LTA fraction. Interestingly, the induction periods of FAU and LTA in the FAU/LTA composite zeolite ([Na2 O] is 0.072) are both 13 h, quite different from the induction periods of their individual pure phases—45 h for FAU and 4 h for LTA. During the crystallization, the LTA/(FAU + LTA) fraction in the composite zeolite decreases in a nearly linear fashion. Scanning electron microscopy, thermogravimetry and differential thermal analysis indicate some difference between the properties of the FAU/LTA composite zeolite and of the mechanical mixture. PMID:27877264

  17. Phase selection controlled by sodium ions in the synthesis of FAU/LTA composite zeolite.

    PubMed

    Hu, Linyan; Xie, Sujuan; Wang, Qingxia; Liu, Shenglin; Xu, Longya

    2009-02-01

    Zeolite faujasite (FAU), Linde type A (LTA) and FAU/LTA composite have been synthesized using tetramethylammonium cation (TMA(+)) as template, by adjusting only the concentration of Na(+) ions in the initial solution (1.00 Al2O3 4.36 SiO2 : 2.39 (TMA)2 O : β Na2 O : 249.00H2 O). Na(+) ions alter the phase composition of the product more than TMA(+) or OH(-) ions. When Na2 O concentration [Na2 O] increases from 0.024 to 0.168, the product gradually changes from pure FAU to pure LTA via the formation of FAU/LTA composite with increasing LTA fraction. Interestingly, the induction periods of FAU and LTA in the FAU/LTA composite zeolite ([Na2 O] is 0.072) are both 13 h, quite different from the induction periods of their individual pure phases-45 h for FAU and 4 h for LTA. During the crystallization, the LTA/(FAU + LTA) fraction in the composite zeolite decreases in a nearly linear fashion. Scanning electron microscopy, thermogravimetry and differential thermal analysis indicate some difference between the properties of the FAU/LTA composite zeolite and of the mechanical mixture.

  18. Phase selection controlled by sodium ions in the synthesis of FAU/LTA composite zeolite

    NASA Astrophysics Data System (ADS)

    Hu, Linyan; Xie, Sujuan; Wang, Qingxia; Liu, Shenglin; Xu, Longya

    2009-01-01

    Zeolite faujasite (FAU), Linde type A (LTA) and FAU/LTA composite have been synthesized using tetramethylammonium cation (TMA +) as template, by adjusting only the concentration of Na + ions in the initial solution (1.00 Al2 O3 4.36 SiO2 : 2.39 (TMA)2 O : β Na2 O : 249.00H2 O). Na + ions alter the phase composition of the product more than TMA+ or OH- ions. When Na2 O concentration [Na2 O] increases from 0.024 to 0.168, the product gradually changes from pure FAU to pure LTA via the formation of FAU/LTA composite with increasing LTA fraction. Interestingly, the induction periods of FAU and LTA in the FAU/LTA composite zeolite ([Na2 O] is 0.072) are both 13 h, quite different from the induction periods of their individual pure phases—45 h for FAU and 4 h for LTA. During the crystallization, the LTA/(FAU + LTA) fraction in the composite zeolite decreases in a nearly linear fashion. Scanning electron microscopy, thermogravimetry and differential thermal analysis indicate some difference between the properties of the FAU/LTA composite zeolite and of the mechanical mixture.

  19. Airship logistics: The LTA vehicle; a total cargo system

    NASA Technical Reports Server (NTRS)

    Hackney, L. R. M.

    1975-01-01

    Design considerations for logistics are dealt with as they pertain to the large rigid LTA vehicle as either a commercial or military cargo carrier. Pertinent factors discussed are: (1) the basic mission; (2) types of payload; (3) the payload space in regards to configuration and sizing, its capacity, and its loadability. A logistic capability comparison of selected cargo airships versus jumbo jets is also made.

  20. 21 CFR 152.126 - Frozen cherry pie.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Frozen cherry pie. 152.126 Section 152.126 Food... HUMAN CONSUMPTION FRUIT PIES Requirements for Specific Standardized Fruit Pies § 152.126 Frozen cherry pie. (a) Identity. (1) Frozen cherry pie (excluding baked and then frozen) is the food prepared...

  1. 21 CFR 152.126 - Frozen cherry pie.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Frozen cherry pie. 152.126 Section 152.126 Food... HUMAN CONSUMPTION FRUIT PIES Requirements for Specific Standardized Fruit Pies § 152.126 Frozen cherry pie. (a) Identity. (1) Frozen cherry pie (excluding baked and then frozen) is the food prepared...

  2. 21 CFR 152.126 - Frozen cherry pie.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Frozen cherry pie. 152.126 Section 152.126 Food... HUMAN CONSUMPTION FRUIT PIES Requirements for Specific Standardized Fruit Pies § 152.126 Frozen cherry pie. (a) Identity. (1) Frozen cherry pie (excluding baked and then frozen) is the food prepared...

  3. 21 CFR 152.126 - Frozen cherry pie.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Frozen cherry pie. 152.126 Section 152.126 Food... HUMAN CONSUMPTION FRUIT PIES Requirements for Specific Standardized Fruit Pies § 152.126 Frozen cherry pie. (a) Identity. (1) Frozen cherry pie (excluding baked and then frozen) is the food prepared...

  4. 21 CFR 152.126 - Frozen cherry pie.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Frozen cherry pie. 152.126 Section 152.126 Food... HUMAN CONSUMPTION FRUIT PIES Requirements for Specific Standardized Fruit Pies § 152.126 Frozen cherry pie. (a) Identity. (1) Frozen cherry pie (excluding baked and then frozen) is the food prepared...

  5. Polypropylene glycol is a selective binding inhibitor for LTA and other structurally related TLR2 agonists.

    PubMed

    Draing, Christian; Traub, Stephanie; Deininger, Susanne; Mang, Philippa; Möller, Heiko M; Manso, Miguel; Rossi, Francois; Morath, Siegfried; Hartung, Thomas; von Aulock, Sonja

    2008-03-01

    Polypropylene glycol (PPG) is commonly added to bacterial cultures to avoid foaming. However, lipoteichoic acid (LTA) from bacteria grown with PPG lacked cytokine-inducing potency in human blood. We tested the blocking efficacy of several glycols on the cytokine response to staphylococcal LTA in human blood. PPG 1200 was the most potent inhibitor tested, shown for TNF, IL-1beta, IL-6, IL-8, IL-10 and TGF-beta induction, and displayed no cytotoxic effects. TNF induction by Staphylococcus aureus or by Toll-like receptor (TLR)2 agonists (di- and triacylated lipopeptides and LTA) was also inhibited by PPG 1200, but not that induced by Escherichia coli or TLR4 agonists. In flow cytometric studies, PPG-carrying nanobeads bound more rhodamine-labeled LTA than those with glycerol. Additionally, the methyl group peak in the (1)H-NMR of LTA shifted after incubation with increasing PPG 1200 concentrations. Sequential incubation of polystyrene plates with LTA, then PPG 1200 and then blood, with washing steps in between, showed that LTA-induced TNF release was inhibited. But when PPG 1200 was pre-incubated with blood that was washed before LTA was added, TNF induction was not repressed, demonstrating that PPG binds LTA and not cellular structures. In summary, PPG 1200 is a novel inhibitor of cytokine induction by TLR2 agonists, which interferes directly with the ligands.

  6. 9 CFR 319.500 - Meat pies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Meat pies. 319.500 Section 319.500... ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION DEFINITIONS AND STANDARDS OF IDENTITY OR COMPOSITION Meat Food Entree Products, Pies,...

  7. 9 CFR 319.500 - Meat pies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Meat pies. 319.500 Section 319.500... ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION DEFINITIONS AND STANDARDS OF IDENTITY OR COMPOSITION Meat Food Entree Products, Pies,...

  8. Hybrid LTA vehicle controllability as affected by buoyancy ratio

    NASA Technical Reports Server (NTRS)

    Meyers, D. N.; Kubicki, P.; Tarczynski, T.; Fairbanks, A.; Piasecki, F. N.

    1979-01-01

    The zero and low speed controllability of heavy lift airships under various wind conditions as affected by the buoyancy ratio are investigated. A series of three hybrid LTA vehicls were examined, each having a dynamic thrust system comprised of four H-34 helicopters, but with buoyant envelopes of different volumes (and hence buoyancies), and with varying percentage of helium inflation and varying useful loads (hence gross weights). Buoyancy ratio, B, was thus examined varying from approximately 0.44 to 1.39. For values of B greater than 1.0, the dynamic thrusters must supply negative thrust (i.e. downward).

  9. Post irradiation effects (PIE) in integrated circuits

    NASA Technical Reports Server (NTRS)

    Shaw, D. C.; Lowry, L.; Barnes, C.; Zakharia, M.; Agarwal, S.; Rax, B.

    1991-01-01

    Post-irradiation effects (PIE) ranging from normal recovery to catastrophic failure have been observed in integrated circuits during the PIE period. Data presented show failure due to rebound after a 10 krad(Si) dose. In particular, five device types are investigated with varying PIE response. Special attention has been given to the HI1-507A analog multiplexer because its PIE response is extreme. X-ray diffraction has been uniquely employed to measure physical stress in the HI1-507A metallization. An attempt has been made to show a relationship between stress relaxation and radiation effects. All data presented support the current MIL-STD Method 1019.4 but demonstrate the importance of performing PIE measurements, even when mission doses are as low as 10 krad(Si).

  10. LTA application of a long trailing wire high speed/low weight reeling system

    NASA Technical Reports Server (NTRS)

    Werb, D. F.

    1975-01-01

    The successful development of a unique yet simple reeling system for handling long trailing tensile members at high speeds is described. This high speed when combined with the system simplicity, low weight and effective motive power consumption make this reeling system particularly attractive to LTA planners and designers for numerous LTA missions.

  11. 46 CFR 16.109 - Public Interest Exclusion (PIE).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Public Interest Exclusion (PIE). 16.109 Section 16.109... General § 16.109 Public Interest Exclusion (PIE). Service agents are subject to Public Interest Exclusion (PIE) actions in accordance with 49 CFR Part 40, subpart R. The PIE is an action which excludes...

  12. Extended pie menus for immersive virtual environments.

    PubMed

    Gebhardt, Sascha; Pick, Sebastian; Leithold, Franziska; Hentschel, Bernd; Kuhlen, Torsten

    2013-04-01

    Pie menus are a well-known technique for interacting with 2D environments and so far a large body of research documents their usage and optimizations. Yet, comparatively little research has been done on the usability of pie menus in immersive virtual environments (IVEs). In this paper we reduce this gap by presenting an implementation and evaluation of an extended hierarchical pie menu system for IVEs that can be operated with a six-degrees-of-freedom input device. Following an iterative development process, we first developed and evaluated a basic hierarchical pie menu system. To better understand how pie menus should be operated in IVEs, we tested this system in a pilot user study with 24 participants and focus on item selection. Regarding the results of the study, the system was tweaked and elements like check boxes, sliders, and color map editors were added to provide extended functionality. An expert review with five experts was performed with the extended pie menus being integrated into an existing VR application to identify potential design issues. Overall results indicated high performance and efficient design.

  13. The development of novel LTA4H modulators to selectively target LTB4 generation

    PubMed Central

    Low, Caroline M.; Akthar, Samia; Patel, Dhiren F.; Löser, Stephan; Wong, Chi-Tung; Jackson, Patricia L.; Blalock, J. Edwin; Hare, Stephen A.; Lloyd, Clare M.; Snelgrove, Robert J.

    2017-01-01

    The pro-inflammatory mediator leukotriene B4 (LTB4) is implicated in the pathologies of an array of diseases and thus represents an attractive therapeutic target. The enzyme leukotriene A4 hydrolase (LTA4H) catalyses the distal step in LTB4 synthesis and hence inhibitors of this enzyme have been actively pursued. Despite potent LTA4H inhibitors entering clinical trials all have failed to show efficacy. We recently identified a secondary anti-inflammatory role for LTA4H in degrading the neutrophil chemoattractant Pro-Gly-Pro (PGP) and rationalized that the failure of conventional LTA4H inhibitors may be that they inadvertently prevented PGP degradation. We demonstrate that these inhibitors do indeed fail to discriminate between the dual activities of LTA4H, and enable PGP accumulation in mice. Accordingly, we have developed novel compounds that potently inhibit LTB4 generation whilst leaving PGP degradation unperturbed. These novel compounds could represent a safer and superior class of LTA4H inhibitors for translation into the clinic. PMID:28303931

  14. The development of novel LTA4H modulators to selectively target LTB4 generation

    NASA Astrophysics Data System (ADS)

    Low, Caroline M.; Akthar, Samia; Patel, Dhiren F.; Löser, Stephan; Wong, Chi-Tung; Jackson, Patricia L.; Blalock, J. Edwin; Hare, Stephen A.; Lloyd, Clare M.; Snelgrove, Robert J.

    2017-03-01

    The pro-inflammatory mediator leukotriene B4 (LTB4) is implicated in the pathologies of an array of diseases and thus represents an attractive therapeutic target. The enzyme leukotriene A4 hydrolase (LTA4H) catalyses the distal step in LTB4 synthesis and hence inhibitors of this enzyme have been actively pursued. Despite potent LTA4H inhibitors entering clinical trials all have failed to show efficacy. We recently identified a secondary anti-inflammatory role for LTA4H in degrading the neutrophil chemoattractant Pro-Gly-Pro (PGP) and rationalized that the failure of conventional LTA4H inhibitors may be that they inadvertently prevented PGP degradation. We demonstrate that these inhibitors do indeed fail to discriminate between the dual activities of LTA4H, and enable PGP accumulation in mice. Accordingly, we have developed novel compounds that potently inhibit LTB4 generation whilst leaving PGP degradation unperturbed. These novel compounds could represent a safer and superior class of LTA4H inhibitors for translation into the clinic.

  15. Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H

    PubMed Central

    Xiao, Qiang; Dong, Ningning; Yao, Xue; Wu, Dang; Lu, Yanli; Mao, Fei; Zhu, Jin; Li, Jian; Huang, Jin; Chen, Aifang; Huang, Lu; Wang, Xuehai; Yang, Guangxiao; He, Guangyuan; Xu, Yong; Lu, Weiqiang

    2016-01-01

    Neutrophils play an important role in the occurrence and development of acute lung injury (ALI). Leukotriene B4 (LTB4), a hydrolysis product of epoxide leukotriene A4 (LTA4) catalyzed by LTA4 hydrolase (LTA4H), is one of the most potent chemoattractants for neutrophil. Bufexamac is a drug widely used as an anti-inflammatory agent on the skin, however, the mechanism of action is still not fully understood. In this study, we found bufexamac was capable of specifically inhibiting LTA4H enzymatic activity and revealed the mode of interaction of bufexamac and LTA4H using X-ray crystallography. Moreover, bufexamac significantly prevented the production of LTB4 in neutrophil and inhibited the fMLP-induced neutrophil migration through inhibition of LTA4H. Finally, bufexamac significantly attenuated lung inflammation as reflected by reduced LTB4 levels and weakened neutrophil infiltration in bronchoalveolar lavage fluid from a lipopolysaccharide-induced ALI mouse model. In summary, our study indicates that bufexamac acts as an inhibitor of LTB4 biosynthesis and may have potential clinical applications for the treatment of ALI. PMID:27126280

  16. 49 CFR 40.367 - Who initiates a PIE proceeding?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Who initiates a PIE proceeding? 40.367 Section 40... DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.367 Who initiates a PIE proceeding? The following DOT officials may initiate a PIE proceeding: (a) The drug and alcohol program manager...

  17. The Mini-Casebook--Easy As Pie.

    ERIC Educational Resources Information Center

    Blythe, Hal; Sweet, Charlie

    2003-01-01

    Presents a casebook on the song "American Pie" that considers how to define the parameters of short narrative. Describes the creation of an end-of-term cumulative writing project that the authors have successfully employed for the last decade. Discusses how they put together a casebook that teaches the necessary research skills. (SG)

  18. Direct Logistic Fuel JP-8 Conversion in a Liquid Tin Anode Solid Oxide Fuel Cell (LTA-SOFC)

    DTIC Science & Technology

    2008-04-09

    Oxide Fuel Cell (LTA- SOFC ) Prepared By CellTech Power , LLC, 131 Flanders Road, MA, 01581 April, 2008 Final Report Contract... REPORT Direct Logistic Fuel JP-8 Conversion in a Liquid Tin Anode Solid Oxide Fuel Cell (LTA- SOFC ) 14. ABSTRACT 16. SECURITY CLASSIFICATION OF: This...logistic fuel only. The aim of this program was to advance LTA- SOFC technology with respect to direct conversion of JP-8. U 1. REPORT DATE (DD-MM-YYYY) 4

  19. A revolutionary and operational tethered aerostat system illustrating new LTA technology. [for ground-air-ground communications

    NASA Technical Reports Server (NTRS)

    Menke, J. A.

    1975-01-01

    An operational tethered aerostat system, which demonstrates utility of LTA systems, is described. It was made possible by development of a reliable tethered aerostat that is used to support broadcast equipment at an altitude of 10,000 feet. Two elements of the TCOM system, the aerostat and mooring station, are particularly relevant to the LTA Workshop. They demonstrate the feasibility of using LTA vehicles in real, operational, all-weather applications and, in addition, illustrate an advance in the overall technology base of LTA. The aerostat and the mooring station, including their technical design features and demonstrated performance characteristics, are described.

  20. Listeria monocytogenes MDR transporters are involved in LTA synthesis and triggering of innate immunity during infection

    PubMed Central

    Tadmor, Keren; Pozniak, Yair; Burg Golani, Tamar; Lobel, Lior; Brenner, Moran; Sigal, Nadejda; Herskovits, Anat A.

    2014-01-01

    Multi-drug resistance (MDR) transporters are known eponymously for their ability to confer resistance to various antimicrobial drugs. However, it is likely that this is not their primary function and that MDR transporters evolved originally to play additional roles in bacterial physiology. In Listeria monocytogenes a set of MDR transporters was identified to mediate activation of innate immune responses during mammalian cell infection. This phenotype was shown to be dependent on c-di-AMP secretion, but the physiological processes underlying this phenomenon were not completely resolved. Here we describe a genetic approach taken to screen for L. monocytogenes genes or physiological pathways involved in MDR transporter-dependent triggering of the type I interferon response. We found that disruption of L. monocytogenes lipoteichoic acid (LTA) synthesis results in enhanced triggering of type I interferon responses in infected macrophage cells yet does not impact bacterial intracellular growth. This innate immune response required the MDR transporters and could be recapitulated by exposing macrophage cells to culture supernatants derived from LTA mutant bacteria. Notably, we found that the MDR transporters themselves are required for full production of LTA, an observation that links MDR transporters to LTA synthesis for the first time. In light of our findings, we propose that the MDR transporters play a role in regulating LTA synthesis, possibly via c-di-AMP efflux, a physiological function in cell wall maintenance that triggers the host innate immune system. PMID:24611134

  1. Pie de Palo, Argentina: A cataclastic diapir

    NASA Astrophysics Data System (ADS)

    Vita-Finzi, Claudio

    2009-03-01

    The term cataclastic diapirism is proposed for the low-temperature extrusion of highly fractured rocks through more competent strata to produce domed topographies at the surface. The process is illustrated by reference to the geomorphology, neotectonics and microseismicity of the Pie de Palo, an elongated ridge in the western Sierras Pampeanas of Argentina composed of shattered and sheared Lower Palaeozoic rocks and subject to coseismic uplift. The Pie de Palo is conventionally interpreted as a fault-driven basement fold linked to low-angle eastward subduction of the Nazca plate beneath South America; the diapiric model implies instead that deformation is powered by regional compression from west-verging, near-surface, crustal shortening which results ultimately from Atlantic spreading.

  2. PIE preparation of the MEGAPIE target

    NASA Astrophysics Data System (ADS)

    Wohlmuther, Michael; Wagner, Werner

    2012-12-01

    The MEGAPIE target, after successfully operating for 4 months at a beam power of 0.77 MW, is now being prepared for post irradiation examination PIE. The lead-bismuth eutectic (LBE) target was irradiated from August until December 2006, and in this period received a beam charge of 2.8 A h of 575 MeV protons. After that, the target was stored in the target storage facility of PSI, waiting for its post irradiation examination. In the meantime several campaigns of tests have been conducted by PSI and ZWILAG, the interim storage facility of Swiss nuclear power plants. In these tests the feasibility of the conditioning of the target and the extraction of sample material for the PIE has been proven. After transport to the hot cell facility at ZWILAG in June 2009, the dismantling of the MEGAPIE target started. It finally was cut into 21 pieces. Ten of these pieces will be shipped to the Hot Laboratory of PSI ('PSI hotlab') to extract samples from the structural materials as well as from the LBE. Currently it is foreseen that the sample extraction will start in the first half of 2011. The remaining parts of the MEGAPIE target were conditioned as radioactive waste. The present paper will mainly focus on the dismantling and first visual inspection of the MEGAPIE target. In addition an outlook on the PIE phase of MEGAPIE is given.

  3. Revised numerical wrapper for PIES code

    NASA Astrophysics Data System (ADS)

    Raburn, Daniel; Reiman, Allan; Monticello, Donald

    2015-11-01

    A revised external numerical wrapper has been developed for the Princeton Iterative Equilibrium Solver (PIES code), which is capable of calculating 3D MHD equilibria with islands. The numerical wrapper has been demonstrated to greatly improve the rate of convergence in numerous cases corresponding to equilibria in the TFTR device where magnetic islands are present. The numerical wrapper makes use of a Jacobian-free Newton-Krylov solver along with adaptive preconditioning and a sophisticated subspace-restricted Levenberg-Marquardt backtracking algorithm. The details of the numerical wrapper and several sample results are presented.

  4. Sex and the Cinema: What "American Pie" Teaches the Young

    ERIC Educational Resources Information Center

    Pearce, Sharyn

    2006-01-01

    This paper focuses on the wildly successful blockbuster "American Pie" teenpics, especially "American Pie 3--The Wedding". I argue that these films are specifically designed to appeal to teenage male audiences, and to provide lessons in sex and romance. Movies like this are especially important as they are experienced by far more teenagers than,…

  5. Characterisation of TNF block haplotypes affecting the production of TNF and LTA.

    PubMed

    Tan, J H; Temple, S E L; Kee, C; Waterer, G W; Tan, C R T; Gut, I; Price, P

    2011-02-01

    Polymorphisms in the central major histocompatibility complex (MHC) (particularly TNF and adjacent genes) associate with several immunopathological diseases and with susceptibility to pneumonia. The MHC is characterised by strong linkage disequilibrium (LD), so identification of loci affecting disease must be based on haplotypes. We have defined 31 tumour necrosis factor (TNF) block haplotypes (denoted FV1-31) in Caucasians, Asians and Australian Aboriginals. This study correlates the carriage of TNF block haplotypes with TNF and lymphotoxin alpha (LTA) protein production by peripheral blood mononuclear cells from 205 healthy Caucasian subjects, following in vitro stimulation with Streptococcus pneumoniae (S. pneumoniae; gram-positive bacteria), Escherichia coli (E. coli; gram-negative bacteria) or TNF over 4, 8 and 24 h. Fifteen haplotypes were present at >1%, accounting for 94.5% of the cohort. The haplotypes were grouped into five families based on common alleles. Following stimulation, cells from carriers of the FV10 haplotype (family 2) produced less LTA compared with non-FV10 carriers. Carriers of the FV18 haplotype (family 4) produced more LTA than other donors. Induction of TNF by S. pneumoniae following 24 h stimulation was also greater in donors with FV18. The FV18 haplotype associated with the 44.1 MHC ancestral haplotype (HLA-A2, -C5, -B44, -DRB1*0401 and -DQB1*0301) that has few disease associations. FV16 occurred in the 8.1 MHC haplotype (HLA-A2, B8, DR3) that is associated with multiple immunopathological diseases. FV16 did not affect TNF or LTA levels. The findings suggest that many genetic variations critical in vivo are not effectively modelled by short-term cultures.

  6. LUNAR MODULE TEST ARTICLE [LTA] [2R] IS MOVED FOR MATING TO LUNAR MODULE ADAPTER

    NASA Technical Reports Server (NTRS)

    1967-01-01

    The Lunar Module Test Article [LTA] 2R, for the second Saturn V mission, is being moved from the low bay of the Manned Spacecraft Operations Building for mating with the spacecraft Lunar Module Adapter. The second Saturn V [502], except for a different lunar return trajectory, will be a repeat of the Apollo 4 unmanned Earth orbital flight of a high apogee for systems testing using several propulsion system burns and a heat shield test at lunar re-entry speed.

  7. Gene expression of 5-lipoxygenase and LTA4 hydrolase in renal tissue of nephrotic syndrome patients

    PubMed Central

    Menegatti, E; Roccatello, D; Fadden, K; Piccoli, G; De Rosa, G; Sena, L M; Rifai, A

    1999-01-01

    Leukotrienes (LT) of the 5-lipoxygenase pathway constitute a class of potent biological lipid mediators of inflammation implicated in the pathogenesis of different models of experimental glomerulonephritis. The key enzyme, 5-lipoxygenase (5-LO), catalyses oxygenation of arachidonic acid to generate the primary leukotriene LTA4. This LT, in turn, serves as a substrate for either LTA4 hydrolase, to form the potent chemoattractant LTB4, or LTC4 synthase, to produce the powerful vasoconstrictor LTC4. To investigate the potential role of LT in the pathogenesis of human glomerulonephritis with nephrotic syndrome, we examined the gene expression of 5-LO and LTA4 hydrolase in renal tissue of 21 adult patients with nephrotic syndrome and 11 controls. The patients consisted of 11 cases of membranous nephropathy (MN), seven focal and segmental glomerulosclerosis (FSGS), two non-IgA mesangial glomerulonephritis and one minimal change disease. Total RNA purified from renal tissue was reverse transcribed into cDNA and amplified with specific primers in a polymerase chain reaction (RT-PCR). Eight patients' renal tissue, four MN and four FSGS, co-expressed 5-LO and LTA4 hydrolase. In situ hybridization analysis revealed 5-LO expression and distribution limited to the interstitial cells surrounding the peritubular capillaries. Comparative clinical and immunohistological data showed that these eight patients had impaired renal function and interstitial changes that significantly correlated with 5-LO expression. These findings suggest that leukotrienes may play an important role in the pathogenesis of MN and FSGS. These results are also relevant to elucidating the pathophysiologic mechanisms which underlie progression to renal failure in these diseases. PMID:10337029

  8. Crystal structures of Sr-diphylloaluminosilicates synthesized from LTA and FAU zeolites

    NASA Astrophysics Data System (ADS)

    Nedić, Bojana; Kremenović, Aleksandar; Dimitrijević, Radovan; Dondur, Vera

    2008-02-01

    Crystal structures of stoichiometric and non-stoichiometric Sr-diphylloaluminosilicate phases are solved and refined using X-ray powder diffraction (XRPD) data by Rietveld method in trigonal space group P3¯c1 (No. 165) and hexagonal space group P6 3/ mcm (No. 193), respectively. The stoichiometric phase is synthesized from the Sr-LTA zeolite, whereas the non-stoichiometric phase is prepared from the Sr-FAU zeolite by thermal treatment. Structural models described in the space group P3¯c1 are refined to the agreement factors: Rexp = 3.32, Rp = 6.63, Rwp = 9.27, RB = 3.70 for Sr-diphylloaluminosilicate LTA and Rexp = 3.64, Rp = 7.06, Rwp = 10.1, RB = 3.76 for Sr-diphylloaluminosilicate FAU. Structural models described in the space group P6 3/ mcm are refined to the agreement factors: Rexp = 3.32, Rp = 6.50, Rwp = 9.10, RB = 3.40 for Sr-diphylloaluminosilicate LTA and Rexp = 3.64, Rp = 6.92, Rwp = 9.90, RB = 3.55 for Sr-diphylloaluminosilicate FAU. Vacancies in the positions occupied by the Sr 2+ ions are characteristic of the Sr-diphylloaluminosilicate FAU structure.

  9. Comparison of the STA/LTA and power spectral density methods for microseismic event detection

    NASA Astrophysics Data System (ADS)

    Vaezi, Yoones; Van der Baan, Mirko

    2015-12-01

    Robust event detection and picking is a prerequisite for reliable (micro-) seismic interpretations. Detection of weak events is a common challenge among various available event detection algorithms. In this paper we compare the performance of two event detection methods, the short-term average/long-term average (STA/LTA) method, which is the most commonly used technique in industry, and a newly introduced method that is based on the power spectral density (PSD) measurements. We have applied both techniques to a 1-hr long segment of the vertical component of some raw continuous data recorded at a borehole geophone in a hydraulic fracturing experiment. The PSD technique outperforms the STA/LTA technique by detecting a higher number of weak events while keeping the number of false alarms at a reasonable level. The time-frequency representations obtained through the PSD method can also help define a more suitable bandpass filter which is usually required for the STA/LTA method. The method offers thus much promise for automated event detection in industrial, local, regional and global seismological data sets.

  10. Propulsion Induced Effects (PIE) Test Program

    NASA Technical Reports Server (NTRS)

    Cappuccio, Gelsomina; Won, Mark J.

    1999-01-01

    The Propulsion Induced Effects (PIE) test program is being lead by NASA Ames for Configuration Aerodynamics (CA). Representatives from CA, Technology Integration (TI), Inlet, and the Nozzle ITD's are working with Ames in defining and executing this test program. The objective of the CA 4-14 milestone is to assess the propulsion/airframe integration characteristics of the Technology Concept Airplane (TCA) and design variations using computational and experimental methods. The experimental aspect includes static calibrations, transonic and supersonic wind tunnel testing. The test program will generate a comprehensive database that will include all appropriate wind tunnel corrections, with emphasis placed on establishing the propulsion induced effects on the flight performance of the TCA.

  11. 49 CFR 40.379 - How do you contest the issuance of a PIE?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false How do you contest the issuance of a PIE? 40.379... issuance of a PIE? (a) If you receive a NOPE, you may contest the issuance of the PIE. (b) If you want to contest the proposed PIE, you must provide the Director information and argument in opposition to...

  12. 49 CFR 40.377 - Who decides whether to issue a PIE?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Who decides whether to issue a PIE? 40.377 Section... a PIE? (a) The ODAPC Director, or his or her designee, decides whether to issue a PIE. If a designee... determination about whether to start a PIE proceeding. (c) There is a “firewall” between the initiating...

  13. 49 CFR 40.363 - On what basis may the Department issue a PIE?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false On what basis may the Department issue a PIE? 40... the Department issue a PIE? (a) If you are a service agent, the Department may issue a PIE concerning... also may issue a PIE if you have failed to cooperate with DOT agency representatives...

  14. First Images from the 74 MHz VLA - Pie Town Link

    NASA Astrophysics Data System (ADS)

    Lane, W. M.; Cohen, A. S.; Kassim, N. E.; Lazio, T. J. W.

    2005-12-01

    A 74 MHz (4m wavelength) receiver has now been added to the VLBA antenna at Pie Town, bringing the full resolving power of the VLA + Pie Town Link to this low frequency. With baselines up to 73 km, corresponding to resolutions of ˜10 arcsec, and sensitivities ˜20 mJy bm-1, the first observations shown here have achieved by far the highest resolution and sensitivity of any images at this frequency to date.

  15. Decommissioning and PIE of the MEGAPIE spallation target

    SciTech Connect

    Latge, C.; Henry, J.; Wohlmuther, M.; Dai, Y.; Gavillet, D.; Hammer, B.; Heinitz, S.; Neuhausen, J.; Schumann, D.; Thomsen, K.; Tuerler, A.; Wagner, W.; Gessi, A.; Guertin, A.; Konstantinovic, M.; Lindau, R.; Maloy, S.; Saito, S.

    2013-07-01

    A key experiment in the Accelerated Driven Systems roadmap, the MEGAwatt PIlot Experiment (MEGAPIE) (1 MW) was initiated in 1999 in order to design and build a liquid lead-bismuth spallation target, then to operate it into the Swiss spallation neutron facility SINQ at Paul Scherrer Institute. The target has been designed, manufactured, and tested during integral tests, before irradiation carried out end of 2006. During irradiation, neutron and thermo hydraulic measurements were performed allowing deep interpretation of the experiment and validation of the models used during design phase. The decommissioning, Post Irradiation Examinations and waste management phases were defined properly. The phases dedicated to cutting, sampling, cleaning, waste management, samples preparation and shipping to various laboratories were performed by PSI teams: all these phases constitute a huge work, which allows now to perform post-irradiation examination (PIE) of structural material, irradiated in relevant conditions. Preliminary results are presented in the paper, they concern chemical characterization. The following radio-nuclides have been identified by γ-spectrometry: {sup 60}Co, {sup 101}Rh, {sup 102}Rh, {sup 108m}Ag, {sup 110m}Ag, {sup 133}Ba, {sup 172}Hf/Lu, {sup 173}Lu, {sup 194}Hg/Au, {sup 195}Au, {sup 207}Bi. For some of these nuclides the activities can be easily evaluated from γ-spectrometry results ({sup 207}Bi, {sup 194}Hg/Au), while other nuclides can only be determined after chemical separations ({sup 108m}Ag, {sup 110m}Ag, {sup 195}Au, {sup 129}I, {sup 36}Cl and α-emitting {sup 208-210}Po). The concentration of {sup 129}I is lower than expected. The chemical analysis already performed on spallation and corrosion products in the lead-bismuth eutectic (LBE) are very relevant for further applications of LBE as a spallation media and more generally as a coolant.

  16. Identifying P-phase arrivals with noise: An improved Kurtosis method based on DWT and STA/LTA

    NASA Astrophysics Data System (ADS)

    Li, Xibing; Shang, Xueyi; Wang, Zewei; Dong, Longjun; Weng, Lei

    2016-10-01

    A discrete wavelet transform (DWT) and short time average to long time average (STA/LTA)-based Kurtosis algorithm (W-S/L-K method) is proposed to pick the arrival time of the P-phase; this method advantageously combines the outstanding ability of retrieving the P-phase arrival information from wavelet coefficients at high resolutions with inherent reliability in obtaining the P-phase arrival time using the STA/LTA picking method. The W-S/L-K method uses local maximum amplitudes and local kurtosis onsets from the wavelet detail components to determine the P-phase arrival times reliably and accurately. It was tested and verified using microseismic data collected from the Yongshaba mine. The results show that the W-S/L-K method's rates of picking errors smaller than 5 ms, 10 ms, and 15 ms were 58%, 86%, and 97.5%, respectively, and the W-S/L-K method was able to pick higher quality P-phase arrival times than those determined using the Kurtosis, Skewness, STA/LTA, Kurtosis + STA/LTA, and Skewness + STA/LTA methods. The proposed method provides a reliable technique for accurately picking P-phase arrival times, especially for signals with low signal to noise ratios (SNRs), heavy tails, and spikes. Moreover, it is able to detect pure noise.

  17. Low pH Environmental Stress Inhibits LPS and LTA-Stimulated Proinflammatory Cytokine Production in Rat Alveolar Macrophages

    PubMed Central

    Fernandez, Stanley F.; Fung, Christopher; Helinski, Jadwiga D.; Alluri, Ravi; Davidson, Bruce A.; Knight, Paul R.

    2013-01-01

    Gastric aspiration increases the risks for developing secondary bacterial pneumonia. Cytokine elaboration through pathogen recognition receptors (PRRs) is an important mechanism in initiating innate immune host response. Effects of low pH stress, a critical component of aspiration pathogenesis, on the PRR pathways were examined, specifically toll-like receptor-2 (TLR2) and TLR4, using isolated rat alveolar macrophages (aMØs). We assessed the ability of aMØs after brief exposure to acidified saline to elaborate proinflammatory cytokines in response to lipopolysaccharide (LPS) and lipoteichoic acid (LTA) stimulation, known ligands of TLR4 and TLR2, respectively. Low pH stress reduced LPS- and LTA-mediated cytokine release (CINC-1, MIP-2, TNF-α, MCP-1, and IFN-β). LPS and LTA increased intracellular Ca2+ concentrations while Ca2+ chelation by BAPTA decreased LPS- and LTA-mediated cytokine responses. BAPTA blocked the effects of low pH stress on most of LPS-stimulated cytokines but not of LTA-stimulated responses. In vivo mouse model demonstrates suppressed E. coli and S. pneumoniae clearance following acid aspiration. In conclusion, low pH stress inhibits antibacterial cytokine response of aMØs due to impaired TLR2 (MyD88 pathway) and TLR4 signaling (MyD88 and TRIF pathways). The role of Ca2+ in low pH stress-induced signaling is complex but appears to be distinct between LPS- and LTA-mediated responses. PMID:24288685

  18. Code Analyses Supporting PIE of Weapons-Grade MOX Fuel

    SciTech Connect

    Ott, Larry J; Bevard, Bruce Balkcom; Spellman, Donald J; McCoy, Kevin

    2010-01-01

    The U.S. Department of energy has decided to dispose of a portion of the nation's surplus weapons-grade plutonium by reconstituting it into mixed oxide (MOX) fuel and irradiating the fuel in commercial power reactors. Four lead test assemblies (LTAs) were manufactured with weapons-grade mixed oxide (WG-MOX) fuel and irradiated in the Catawba Nuclear Station Unit 1, to a maximum fuel rod burnup of ~47.3 GWd/MTHM. As part of the fuel qualification process, five rods with varying burnups and initial plutonium contents were selected from one assembly and shipped to the Oak Ridge National Laboratory (ORNL) for hot cell examination. ORNL has provided analytical support for the post-irradiation examination (PIE) of these rods via extensive fuel performance modeling which has aided in instrument settings and PIE data interpretation. The results of these fuel performance simulations are compared in this paper with available PIE data.

  19. 49 CFR 40.409 - What does the issuance of a PIE mean to transportation employers?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What does the issuance of a PIE mean to... What does the issuance of a PIE mean to transportation employers? (a) As an employer, you are deemed to have notice of the issuance of a PIE when it appears on the List mentioned in § 40.401(a) or the...

  20. 49 CFR 40.395 - Can you settle a PIE proceeding?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Can you settle a PIE proceeding? 40.395 Section 40... DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.395 Can you settle a PIE proceeding... concurrence, settle a PIE proceeding....

  1. 49 CFR 40.383 - What procedures apply if you contest the issuance of a PIE?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What procedures apply if you contest the issuance of a PIE? 40.383 Section 40.383 Transportation Office of the Secretary of Transportation PROCEDURES... What procedures apply if you contest the issuance of a PIE? (a) DOT conducts PIE proceedings in a...

  2. 49 CFR 40.397 - When does the Director make a PIE decision?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false When does the Director make a PIE decision? 40.397... a PIE decision? The Director makes his or her decision within 60 days of the date when the record of a PIE proceeding is complete (including any meeting with the Director and any additional...

  3. Personalized Information Environments: Do Public Libraries Want a Slice of the PIE?

    ERIC Educational Resources Information Center

    Worcester, Lea

    2003-01-01

    Discussion of personalized information environments (PIEs) focuses on library personalized interfaces. Describes academic library PIEs and commercial sites, such as Amazon.com that use personalization; explores the Public Library of Charlotte and Mecklenburg's personalized interface; and discusses opportunities and challenges PIEs offer public…

  4. 49 CFR 40.385 - Who bears the burden of proof in a PIE proceeding?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Who bears the burden of proof in a PIE proceeding... TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.385 Who bears the burden of proof in a PIE proceeding? (a) As the proponent of issuing a PIE, the initiating official...

  5. 49 CFR 40.385 - Who bears the burden of proof in a PIE proceeding?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Who bears the burden of proof in a PIE proceeding... TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.385 Who bears the burden of proof in a PIE proceeding? (a) As the proponent of issuing a PIE, the initiating official...

  6. 49 CFR 40.385 - Who bears the burden of proof in a PIE proceeding?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Who bears the burden of proof in a PIE proceeding... TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.385 Who bears the burden of proof in a PIE proceeding? (a) As the proponent of issuing a PIE, the initiating official...

  7. 49 CFR 40.385 - Who bears the burden of proof in a PIE proceeding?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Who bears the burden of proof in a PIE proceeding... TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.385 Who bears the burden of proof in a PIE proceeding? (a) As the proponent of issuing a PIE, the initiating official...

  8. 49 CFR 40.385 - Who bears the burden of proof in a PIE proceeding?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Who bears the burden of proof in a PIE proceeding... TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.385 Who bears the burden of proof in a PIE proceeding? (a) As the proponent of issuing a PIE, the initiating official...

  9. Optical and structural studies of CuI clusters in zeolites LTA and FAU

    NASA Astrophysics Data System (ADS)

    Kodaira, Tetsuya; Ikeda, Takuji

    2006-05-01

    CuI clusters were incorporated into α-cages and supercages of zeolites LTA and FAU, respectively, with various loading densities. From the powder XRD measurement of CuI clusters in FAU, it can be concluded that CuI clusters with homogeneous size were distributed in the cages. In case of using FAU as a host, when the loading density became close to the maximum, photo absorption intensity gradually decreased. A polariton effect, i.e. photo excited energy transfers among the clusters, may play an important role on this phenomenon. Cu and I atoms of bulk CuI crystal have tetrahedral chemical bondings. Supercages of FAU have an arrangement of a diamond structure. Coincidence on the symmetry of the chemical bondings in the CuI clusters and the arrangement of the clusters in the supercages may be the origin of a highly ordered state of CuI clusters and will enhance the polariton effect.

  10. High performance zeolite LTA pervaporation membranes on ceramic hollow fibers by dipcoating-wiping seed deposition.

    PubMed

    Wang, Zhengbao; Ge, Qinqin; Shao, Jia; Yan, Yushan

    2009-05-27

    We demonstrate for the first time that by one single hydrothermal synthesis a zeolite LTA membrane with a high flux of 9.0 kg/m(2) h and high water/ethanol separation factor of 10,000 could be formed on a ceramic hollow fiber that is known for its ability to form a compact module. The flux is the highest reported in the literatures. A novel seeding method, dipcoating-wiping, is key to obtaining zeolite membranes with high separation performance because it reproducibly produces a uniform and trace seed layer on the support. This new seeding method is expected to have serious implications for making defect-free zeolite films and membranes for many applications. The membranes reported here have the potential to solve the key problems that have prevented zeolite membranes from widespread use for biofuel production.

  11. Genetic Variation on the BAT1-NFKBIL1-LTA Region of Major Histocompatibility Complex Class III Associates with Periodontitis

    PubMed Central

    Marchesani, Marja; Vlachopoulou, Efthymia; Mäntylä, Päivi; Paju, Susanna; Buhlin, Kåre; Suominen, Anna L.; Contreras, Johanna; Knuuttila, Matti; Hernandez, Marcela; Huumonen, Sisko; Nieminen, Markku S.; Perola, Markus; Sinisalo, Juha; Lokki, Marja-Liisa; Pussinen, Pirkko J.

    2014-01-01

    Periodontitis is a chronic inflammatory disease with a multifactorial etiology. We investigated whether human major histocompatibility complex (MHC) polymorphisms (6p21.3) are associated with periodontal parameters. Parogene 1 population samples (n = 169) were analyzed with 13,245 single nucleotide polymorphisms (SNPs) of the MHC region. Eighteen selected SNPs (P ≤ 0.001) were replicated in Parogene 2 population samples (n = 339) and the Health 2000 Survey (n = 1,420). All subjects had a detailed clinical and radiographic oral health examination. Serum lymphotoxin-α (LTA) concentrations were measured in the Parogene populations, and the protein was detected in inflamed periodontal tissue. In the Parogene 1 population, 10 SNPs were associated with periodontal parameters. The strongest associations emerged from the parameters bleeding on probing (BOP) and a probing pocket depth (PPD) of ≥6 mm with the genes BAT1, NFKBIL1, and LTA. Six SNPs, rs11796, rs3130059, rs2239527, rs2071591, rs909253, and rs1041981 (r2, ≥0.92), constituted a risk haplotype. In the Parogene 1 population, the haplotype had the strongest association with the parameter BOP, a PPD of ≥6 mm, and severe periodontitis with odds ratios (95% confidence intervals) of 2.63 (2.21 to 3.20), 2.90 (2.37 to 3.52), and 3.10 (1.63 to 5.98), respectively. These results were replicated in the other two populations. High serum LTA concentrations in the Parogene population were associated with the periodontitis risk alleles of the LTA SNPs (rs909253 and rs1041981) of the haplotype. In addition, the protein was expressed in inflamed gingival connective tissue. We identified a novel BAT1-NFKBIL1-LTA haplotype as a significant contributor to the risk of periodontitis. The genetic polymorphisms in the MHC class III region may be functionally important in periodontitis susceptibility. PMID:24566624

  12. Two-Person Pie-Cutting: The Fairest Cuts

    ERIC Educational Resources Information Center

    Barbanel, Julius B.; Brams, Steven J.

    2011-01-01

    Barbanel, Brams, and Stromquist (in 2009) asked whether there exists a two-person moving-knife procedure that yields an envy-free, undominated, and equitable division of a pie. We present two procedures: One yields an envy-free, almost undominated, and almost equitable allocation, whereas the second yields an allocation with the two "almost"…

  13. 9 CFR 381.158 - Poultry dinners (frozen) and pies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Poultry dinners (frozen) and pies. 381... AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Definitions and Standards of Identity...

  14. 9 CFR 381.158 - Poultry dinners (frozen) and pies.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Poultry dinners (frozen) and pies. 381... AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Definitions and Standards of Identity...

  15. 9 CFR 381.158 - Poultry dinners (frozen) and pies.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Poultry dinners (frozen) and pies. 381... AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Definitions and Standards of Identity...

  16. 9 CFR 381.158 - Poultry dinners (frozen) and pies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Poultry dinners (frozen) and pies. 381... AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Definitions and Standards of Identity...

  17. 9 CFR 381.158 - Poultry dinners (frozen) and pies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Poultry dinners (frozen) and pies. 381... AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Definitions and Standards of Identity...

  18. The Cassini Solstice Mission: Streamlining Operations by Sequencing with PIEs

    NASA Technical Reports Server (NTRS)

    Vandermey, Nancy; Alonge, Eleanor K.; Magee, Kari; Heventhal, William

    2014-01-01

    The Cassini Solstice Mission (CSM) is the second extended mission phase of the highly successful Cassini/Huygens mission to Saturn. Conducted at a much-reduced funding level, operations for the CSM have been streamlined and simplified significantly. Integration of the science timeline, which involves allocating observation time in a balanced manner to each of the five different science disciplines (with representatives from the twelve different science instruments), has long been a labor-intensive endeavor. Lessons learned from the prime mission (2004-2008) and first extended mission (Equinox mission, 2008-2010) were utilized to design a new process involving PIEs (Pre-Integrated Events) to ensure the highest priority observations for each discipline could be accomplished despite reduced work force and overall simplification of processes. Discipline-level PIE lists were managed by the Science Planning team and graphically mapped to aid timeline deconfliction meetings prior to assigning discrete segments of time to the various disciplines. Periapse segments are generally discipline-focused, with the exception of a handful of PIEs. In addition to all PIEs being documented in a spreadsheet, allocated out-of-discipline PIEs were entered into the Cassini Information Management System (CIMS) well in advance of timeline integration. The disciplines were then free to work the rest of the timeline internally, without the need for frequent interaction, debate, and negotiation with representatives from other disciplines. As a result, the number of integration meetings has been cut back extensively, freeing up workforce. The sequence implementation process was streamlined as well, combining two previous processes (and teams) into one. The new Sequence Implementation Process (SIP) schedules 22 weeks to build each 10-week-long sequence, and only 3 sequence processes overlap. This differs significantly from prime mission during which 5-week-long sequences were built in 24 weeks

  19. Discovery of the cell-penetrating function of A2 domain derived from LTA subunit of Escherichia coli heat-labile enterotoxin.

    PubMed

    Liu, Di; Guo, Hua; Zheng, Wenyun; Zhang, Na; Wang, Tianwen; Wang, Ping; Ma, Xingyuan

    2016-06-01

    Heat-labile enterotoxin (LT) is a protein toxin produced by enterotoxigenic Escherichia coli (ETEC). As a bacterial toxin, LT holotoxin can enter intestinal epithelial cells and cause diarrhea. In addition, LT is also a powerful mucosal adjuvant capable of enhancing the strong immune responses to co-administered antigens. However, the LT immunological mechanism is still not clear in some aspects, especially with the respect to how the LTA subunit functions alone. Here, we discovered that the A2 domain of LTA could carry a fluorescent protein into cells, whose function is similar to a cell-penetrating peptide. The transmembrane-transporting ability of the A2 domain is non-specific in its cell-penetrating function, which was shown through testing with different cell types. Moreover, the LTA2 fusion protein penetrated a fluorescently labeled cell membrane that identified LTA2 internalization through membrane transport pathways, and showed it finally localized in the endoplasmic reticulum. Furthermore, low-temperature stress and pharmacological agent treatments showed that the LTA2 internalization route is a temperature-dependent process involving the clathrin-mediated endocytosis and the macropinocytosis pathways. These results could explain the internalization of the LTA subunit alone without the LTB pentamer, contributing to a better understanding of LTA working as a mucosal adjuvant; they also suggest that the A2 domain could be used as a novel transport vehicle for research and treatment of disease.

  20. 49 CFR 40.407 - May a service agent ask to have a PIE reduced or terminated?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false May a service agent ask to have a PIE reduced or... agent ask to have a PIE reduced or terminated? (a) Yes, as a service agent concerning whom the Department has issued a PIE, you may request that the Director terminate a PIE or reduce its duration...

  1. Optimization studies of a multikilowatt PIE CO2 laser

    NASA Astrophysics Data System (ADS)

    Nath, A. K.; Seguin, H. J. J.; Seguin, V. A.

    1986-02-01

    Detailes of an investigation of the operational performance of a 10 kW CW PIE CO2 laser are presented. The results obtained from the experiment, successfully scaled by an order of magnitude from an earlier proof-of-principle device, clearly document that the PIE excitation process can be effectively utilized in the design of very large volumen lasers. Optimization data further reveal that overall wallplug efficiency is commensurate with that obtained from E-beam sustained lasers; but at far less complexity and cost. As such, this relatively simple and reliable nonself-sustained excitation process appears attractive commercial for the development of very large and cost effective CW CO2 lasers.

  2. Fully Copper-Exchanged High-Silica LTA Zeolites as Unrivaled Hydrothermally Stable NH3 -SCR Catalysts.

    PubMed

    Ryu, Taekyung; Ahn, Nak Ho; Seo, Seungwan; Cho, Jung; Kim, Hyojun; Jo, Donghui; Park, Gi Tae; Kim, Pyung Soon; Kim, Chang Hwan; Bruce, Elliott L; Wright, Paul A; Nam, In-Sik; Hong, Suk Bong

    2017-03-13

    Diesel engine technology is still the most effective solution to meet tighter CO2 regulations in the mobility and transport sector. In implementation of fuel-efficient diesel engines, the poor thermal durability of lean nitrogen oxides (NOx ) aftertreatment systems remains as one major technical hurdle. Divalent copper ions when fully exchanged into high-silica LTA zeolites are demonstrated to exhibit excellent activity maintenance for NOx reduction with NH3 under vehicle simulated conditions even after hydrothermal aging at 900 °C, a critical temperature that the current commercial Cu-SSZ-13 catalyst cannot overcome owing to thermal deactivation. Detailed structural characterizations confirm the presence of Cu(2+) ions only at the center of single 6-rings that act not only as a catalytically active center, but also as a dealumination suppressor. The overall results render the copper-exchanged LTA zeolite attractive as a viable substitute for Cu-SSZ-13.

  3. OpenMP for 3D potential boundary value problems solved by PIES

    NASA Astrophysics Data System (ADS)

    KuŻelewski, Andrzej; Zieniuk, Eugeniusz

    2016-06-01

    The main purpose of this paper is examination of an application of modern parallel computing technique OpenMP to speed up the calculation in the numerical solution of parametric integral equations systems (PIES). The authors noticed, that solving more complex boundary problems by PIES sometimes requires large computing time. This paper presents the use of OpenMP and fast C++ linear algebra library Armadillo for boundary value problems modelled by 3D Laplace's equation and solved using PIES. The testing example shows that the use of mentioned technologies significantly increases speed of calculations in PIES.

  4. Variants in LTA, TNF, IL1B and IL10 genes associated with the clinical course of sepsis.

    PubMed

    Montoya-Ruiz, Carolina; Jaimes, Fabián A; Rugeles, Maria T; López, Juan Álvaro; Bedoya, Gabriel; Velilla, Paula A

    2016-12-01

    The aim of this study was to explore the association between some SNPs of the TNF, LTA, IL1B and IL10 genes with cytokine concentrations and clinical course in Colombian septic patients. We conducted a cross-sectional study to genotype 415 septic patients and 205 patients without sepsis for the SNPs -308(G/A) rs1800629 of TNF; +252 (G/A) rs909253 of LTA; -511(A/G) rs16944 and +3953(C/T) rs1143634 of IL1B; and -1082(A/G) rs1800896, -819(C/T) rs1800871 and -592(C/A) rs1800872 of IL10. The association of theses SNPs with the following parameters was evaluated: (1) the presence of sepsis; (2) severity and clinical outcomes; (3) APACHE II and SOFA scores; and (4) procalcitonin, C-reactive protein, tumor necrosis factor, lymphotoxin alpha, interleukin 1 beta and interleukin 10 plasma concentrations. We found an association between the SNP LTA +252 with the development of sepsis [OR 1.29 (1.00-1.68)]; the SNP IL10 -1082 with sepsis severity [OR 0.53 (0.29-0.97)]; the TNF -308 with mortality [OR 0.33 (0.12-0.95)]; and the IL10 -592 and IL10 -1082 with admission to the intensive care unit (ICU) [OR 3.36 (1.57-7.18)] and [OR 0.18 (0.04-0.86)], respectively. None of the SNPs were associated with cytokine levels, procalcitonin and C-reactive protein serum concentrations, nor with APACHE II and SOFA scores. Our results suggest that these genetic variants play an important role in the development of sepsis and its clinical course.

  5. Development of the Persistence in Engineering (PIE) Survey Instrument. Research Brief

    ERIC Educational Resources Information Center

    Eris, Ozgur; Chen, Helen; Bailey, Tori; Engerman, Kimarie; Loshbaugh, Heidi; Griffin, Ashley; Lichtenstein, Gary; Cole, Angela

    2007-01-01

    The Persistence In Engineering (PIE) survey was developed to identify and characterize the fundamental factors that influence students' intentions to pursue an engineering degree over the course of their undergraduate career, and upon graduation, to practice engineering as a profession. The PIE survey is one of five data-gathering methods used in…

  6. 49 CFR 40.393 - How long does a PIE stay in effect?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false How long does a PIE stay in effect? 40.393 Section... WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.393 How long does a PIE stay in effect? (a) In the NOPE (see § 40.375(b)(5)), the initiating official proposes the duration of the...

  7. 49 CFR 40.387 - What matters does the Director decide concerning a proposed PIE?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... proposed PIE? 40.387 Section 40.387 Transportation Office of the Secretary of Transportation PROCEDURES FOR... the Director decide concerning a proposed PIE? (a) Following the service agent's response (see § 40... from the service agent (see § 40.379(b)(1)) or on his or her own motion, the Director may dismiss a...

  8. No Humble Pie: The Origins and Usage of a Statistical Chart

    ERIC Educational Resources Information Center

    Spence, Ian

    2005-01-01

    William Playfair's pie chart is more than 200 years old and yet its intellectual origins remain obscure. The inspiration likely derived from the logic diagrams of Llull, Bruno, Leibniz, and Euler, which were familiar to William because of the instruction of his mathematician brother John. The pie chart is broadly popular but--despite its common…

  9. 49 CFR 40.405 - May the Federal courts review PIE decisions?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false May the Federal courts review PIE decisions? 40.405 Section 40.405 Transportation Office of the Secretary of Transportation PROCEDURES FOR... courts review PIE decisions? The Director's decision is a final administrative action of the...

  10. Harnessing the Internet for International Exchanges on Learning Cities: The Pie Experience 2011-2013

    ERIC Educational Resources Information Center

    Kearns, Peter

    2014-01-01

    The PASCAL International Exchanges (PIE) project was developed to facilitate online exchanges of information and experience between learning cities around the world and, in doing this, to test the potential of the internet to enable such low-cost exchanges. The author provides a personal assessment of the PIE experience over the three years 2011…

  11. Relationship between human LTA4H polymorphisms and extra-pulmonary tuberculosis in an ethnic Han Chinese population in Eastern China.

    PubMed

    Yang, Jinghui; Chen, Jin; Yue, Jun; Liu, Lirong; Han, Min; Wang, Hongxiu

    2014-12-01

    Two single nucleotide polymorphisms in Leukotriene A4 hydrolase (LTA4H) gene were reported to be associated with protection from pulmonary tuberculosis in Vietnamese population. But these associations were not found in the Russians. To investigate the association of LTA4H polymorphisms with tuberculosis in a Han Chinese population in Eastern China, we genotyped 5 SNPs of LTA4H gene in 743 of pulmonary tuberculosis patients, 372 of extra-pulmonary tuberculosis patients and 888 of healthy controls individuals. The CC and TT homozygotes of rs1978331 and rs2540474 were identified to have higher rates (P < 0.01) and be risk factors in the patients with extra-pulmonary tuberculosis (OR = 1.412; 95% CI = 1.104-1.804 and(OR = 1.380; 95% CI = 1.080-1.764). However, no significant association was found between any of the SNPs and pulmonary tuberculosis. In the extra-pulmonary tuberculosis subgroups. LTA4H gene were significantly associated with tuberculous meningitis, lymph node tuberculosis, bone tuberculosis and other extra-pulmonary tuberculosis except for pleural tuberculosis. The present findings suggest that polymorphisms in the LTA4H gene may affect susceptibility to extra-pulmonary tuberculosis and change the risk of developing the disease in the Han nationality in the East China.

  12. Magnetic Resonance Imaging: A Tool for Pork Pie Development.

    PubMed

    Gaunt, Adam P; Morris, Robert H; Newton, Michael I

    2013-08-28

    The traditional British pork pie consists of roughly chopped pork cooked in a hot water pastry crust. Due to shrinkage of the meat during cooking, the gap formed around the meat is usually sealed using a gelatin based jelly to exclude air and thus help to preserve the pie. The properties of the jelly are such that it will ingress into the pastry crust causing undesirable softening. The jelly is traditionally produced by simmering pig trotters with seasoning for several hours. In this work we demonstrate the potential of magnetic resonance imaging (MRI) as a tool for investigating the conditions required for producing jellies with different properties and present two examples of this use. Firstly we demonstrate that MRI can determine the ability of water to diffuse through the jelly which is critical in minimizing the amount of moisture moving from the jelly to the crust. Secondly, the impact of jelly temperature on the penetration length into the crust is investigated. These examples highlight the power of MRI as a tool for food assessment.

  13. Introducing a Framework for Physics Innovation and Entrepreneurship (PIE) Education

    NASA Astrophysics Data System (ADS)

    Roughani, Bahram

    A desired outcome for Physics Innovation and Entrepreneurship (PIE) education is preparing physics majors with an innovative and entrepreneurial mindset who are capable of opportunity recognition and adept in leveraging physics knowledge to address specific needs. Physics as a discipline is well-recognized to prepare students who become problem solvers and critical thinkers, gifted in dealing with abstract ideas and ambiguities in the context of complex and real-world problems. These characteristics when enhanced through appropriate combinations of curricular, co-curricular, and extra-curricular programs can prepare physics majors for careers and future challenges that may involve translating physics knowledge into useful products and services either as part of a technical team within an organization or through startups. A viable PIE education model prepares graduates for various career paths in addition to the traditional options such as pursuing graduate studies or becoming a science teacher. Having a well-defined ``third option'' for physics will benefit the robustness of the physics discipline through recruitment and retention of prospective students who in principle are interested in physics as a subject, but in practice they may overlook physics as their preferred major primarily because they are uncertain about a viable career path based on an undergraduate physics education. The ''Pathways to Innovation'' at Loyola is established based on the program developed by VentureWell and Epicenter (NSF Supported).

  14. Random allocation of pies promotes the evolution of fairness in the Ultimatum Game

    PubMed Central

    Wang, Xiaofeng; Chen, Xiaojie; Wang, Long

    2014-01-01

    In the Ultimatum Game, two players are offered a chance to win a pie. The proposer suggests how to split the pie. The responder can either accept or reject the deal. If an agreement is not reached, neither player gets anything. Both game theory and evolutionary game theory predict the rational solution that the proposer offers the smallest possible share and the responder accepts it. Fairness thus requires additional mechanisms for natural selection to favor it. Studies to date assumed that individuals have competed for the fixed size of pies, in sharp contrast with real situations, where randomness is ubiquitous. Here we study the impact of random allocation of pies on the evolution of fairness in the Ultimatum Game. Interestingly, we find that the evolution of fairness can be promoted by the randomness associated with the size of pies, without the support of any additional evolutionary mechanisms. PMID:24686840

  15. 49 CFR 40.381 - What information do you present to contest the proposed issuance of a PIE?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... proposed issuance of a PIE? 40.381 Section 40.381 Transportation Office of the Secretary of Transportation... What information do you present to contest the proposed issuance of a PIE? (a) As a service agent who wants to contest a proposed PIE, you must present at least the following information to the Director:...

  16. 49 CFR 40.403 - Must a service agent notify its clients when the Department issues a PIE?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Department issues a PIE? 40.403 Section 40.403 Transportation Office of the Secretary of Transportation... Must a service agent notify its clients when the Department issues a PIE? (a) As a service agent, if the Department issues a PIE concerning you, you must notify each of your DOT-regulated...

  17. 49 CFR 40.401 - How does the Department notify employers and the public about a PIE?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... public about a PIE? 40.401 Section 40.401 Transportation Office of the Secretary of Transportation... How does the Department notify employers and the public about a PIE? (a) The Department maintains a.... (b) When the Director issues a PIE, he or she adds to the List the name and address of the...

  18. Incorporation of AgI clusters into the cages of zeolites LTA and FAU observed by optical spectra and X-ray diffraction patterns

    NASA Astrophysics Data System (ADS)

    Kodaira, Tetsuya; Ikeda, Takuji; Takeo, Harutoshi

    1999-02-01

    The loading of AgI into the cages of zeolites LTA and FAU was performed by vapor-phase adsorption. The successful incorporation of AgI clusters into the cages was confirmed by optical absorption spectra and X-ray powder diffraction patterns. Large blue shifts of the absorption edges were observed in the spectra of adsorbed AgI to both zeolites, compared with the lowest excited state of AgI in the bulk. The present observation of the shift implies that a strong quantum confinement in the photoexcited state of AgI occurs, which leads to the conclusion that AgI clusters have been formed in the cages. In the X-ray powder diffraction pattern of AgI-loaded LTA, superlattice reflection peaks are observed which cannot be assigned either to the reflection of LTA or the AgI in the bulk.

  19. Temperature-Dependent Electrical Conductivity Measurements on Hydrated and Alkali-metal Intercalated Zeolite LTA and FAU

    NASA Astrophysics Data System (ADS)

    Yumoto, Kenji; Suzuki, Yoshinori; Wada, Noboru

    2007-03-01

    Zeolite LTA and FAU films were made from zeolite powders using a hydrothermal method. Electrical conductivity measurement were performed on the zeolite films in temperature range between 180 K and 430 K, using an LCR meter with the sweeping frequency varied from 20 to 1 MHz and drawing the Cole-Cole plots. The resistivities of both hydrated LTA and FAU zeolites increased with increasing the sample temperature from RT to 430 K, which might be caused by loss of water molecules from the pores of zeolite crystals. Also, the resistivities increased with decreasing the sample temperature from RT to 180 K, probably caused by freezing of water molecules in the zeolite. When the dehydrated zeolite samples were intercalated with alkali metals (Rb and K), the resistivities of the samples did not vary much at RT. However, the resistivities of the intercalated zeolite films decreased drastically by four orders of magnitude when the sample temperature was varied from RT to 180 K. We speculate that the dynamics of alkali atoms in the zeolite pores (electron-phonon scattering) may be responsible for the drastic change in the electrical conductivity.

  20. Lipoteichoic Acid (LTA) and Lipopolysaccharides (LPS) from Periodontal Pathogenic Bacteria Facilitate Oncogenic Herpesvirus Infection within Primary Oral Cells

    PubMed Central

    Dai, Lu; DeFee, Michael R.; Cao, Yueyu; Wen, Jiling; Wen, Xiaofei; Noverr, Mairi C.; Qin, Zhiqiang

    2014-01-01

    Kaposi’s sarcoma (KS) remains the most common tumor arising in patients with HIV/AIDS, and involvement of the oral cavity represents one of the most common clinical manifestations of this tumor. HIV infection incurs an increased risk for periodontal diseases and oral carriage of a variety of bacteria. Whether interactions involving pathogenic bacteria and oncogenic viruses in the local environment facilitate replication or maintenance of these viruses in the oral cavity remains unknown. In the current study, our data indicate that pretreatment of primary human oral fibroblasts with two prototypical pathogen-associated molecular patterns (PAMPs) produced by oral pathogenic bacteria–lipoteichoic acid (LTA) and lipopolysaccharide (LPS), increase KSHV entry and subsequent viral latent gene expression during de novo infection. Further experiments demonstrate that the underlying mechanisms induced by LTA and/or LPS include upregulation of cellular receptor, increasing production of reactive oxygen species (ROS), and activating intracellular signaling pathways such as MAPK and NF-κB, and all of which are closely associated with KSHV entry or gene expression within oral cells. Based on these findings, we hope to provide the framework of developing novel targeted approaches for treatment and prevention of oral KSHV infection and KS development in high-risk HIV-positive patients. PMID:24971655

  1. Structural Conservation and Functional Diversity of the Poxvirus Immune Evasion (PIE) Domain Superfamily.

    PubMed

    Nelson, Christopher A; Epperson, Megan L; Singh, Sukrit; Elliott, Jabari I; Fremont, Daved H

    2015-08-28

    Poxviruses encode a broad array of proteins that serve to undermine host immune defenses. Structural analysis of four of these seemingly unrelated proteins revealed the recurrent use of a conserved beta-sandwich fold that has not been observed in any eukaryotic or prokaryotic protein. Herein we propose to call this unique structural scaffolding the PIE (Poxvirus Immune Evasion) domain. PIE domain containing proteins are abundant in chordopoxvirinae, with our analysis identifying 20 likely PIE subfamilies among 33 representative genomes spanning 7 genera. For example, cowpox strain Brighton Red appears to encode 10 different PIEs: vCCI, A41, C8, M2, T4 (CPVX203), and the SECRET proteins CrmB, CrmD, SCP-1, SCP-2, and SCP-3. Characterized PIE proteins all appear to be nonessential for virus replication, and all contain signal peptides for targeting to the secretory pathway. The PIE subfamilies differ primarily in the number, size, and location of structural embellishments to the beta-sandwich core that confer unique functional specificities. Reported ligands include chemokines, GM-CSF, IL-2, MHC class I, and glycosaminoglycans. We expect that the list of ligands and receptors engaged by the PIE domain will grow as we come to better understand how this versatile structural architecture can be tailored to manipulate host responses to infection.

  2. Structural Conservation and Functional Diversity of the Poxvirus Immune Evasion (PIE) Domain Superfamily

    PubMed Central

    Nelson, Christopher A.; Epperson, Megan L.; Singh, Sukrit; Elliott, Jabari I.; Fremont, Daved H.

    2015-01-01

    Poxviruses encode a broad array of proteins that serve to undermine host immune defenses. Structural analysis of four of these seemingly unrelated proteins revealed the recurrent use of a conserved beta-sandwich fold that has not been observed in any eukaryotic or prokaryotic protein. Herein we propose to call this unique structural scaffolding the PIE (Poxvirus Immune Evasion) domain. PIE domain containing proteins are abundant in chordopoxvirinae, with our analysis identifying 20 likely PIE subfamilies among 33 representative genomes spanning 7 genera. For example, cowpox strain Brighton Red appears to encode 10 different PIEs: vCCI, A41, C8, M2, T4 (CPVX203), and the SECRET proteins CrmB, CrmD, SCP-1, SCP-2, and SCP-3. Characterized PIE proteins all appear to be nonessential for virus replication, and all contain signal peptides for targeting to the secretory pathway. The PIE subfamilies differ primarily in the number, size, and location of structural embellishments to the beta-sandwich core that confer unique functional specificities. Reported ligands include chemokines, GM-CSF, IL-2, MHC class I, and glycosaminoglycans. We expect that the list of ligands and receptors engaged by the PIE domain will grow as we come to better understand how this versatile structural architecture can be tailored to manipulate host responses to infection. PMID:26343707

  3. The causal pie model: an epidemiological method applied to evolutionary biology and ecology.

    PubMed

    Wensink, Maarten; Westendorp, Rudi G J; Baudisch, Annette

    2014-05-01

    A general concept for thinking about causality facilitates swift comprehension of results, and the vocabulary that belongs to the concept is instrumental in cross-disciplinary communication. The causal pie model has fulfilled this role in epidemiology and could be of similar value in evolutionary biology and ecology. In the causal pie model, outcomes result from sufficient causes. Each sufficient cause is made up of a "causal pie" of "component causes". Several different causal pies may exist for the same outcome. If and only if all component causes of a sufficient cause are present, that is, a causal pie is complete, does the outcome occur. The effect of a component cause hence depends on the presence of the other component causes that constitute some causal pie. Because all component causes are equally and fully causative for the outcome, the sum of causes for some outcome exceeds 100%. The causal pie model provides a way of thinking that maps into a number of recurrent themes in evolutionary biology and ecology: It charts when component causes have an effect and are subject to natural selection, and how component causes affect selection on other component causes; which partitions of outcomes with respect to causes are feasible and useful; and how to view the composition of a(n apparently homogeneous) population. The diversity of specific results that is directly understood from the causal pie model is a test for both the validity and the applicability of the model. The causal pie model provides a common language in which results across disciplines can be communicated and serves as a template along which future causal analyses can be made.

  4. Use of Formative Assessment, Self- and Peer-Assessment in the Classrooms: Some Insights from Recent Language Testing and Assessment (LTA) Research

    ERIC Educational Resources Information Center

    Afitska, Oksana

    2014-01-01

    A considerable number of studies on formative teacher assessment and feedback, learner self- and peer-assessment have been carried out in the field of Language Testing and Assessment (LTA) research over the last two decades. These studies investigated the above mentioned concepts from different perspectives (impact of assessment on learning,…

  5. Percutaneous quadriceps tendon pie-crusting release of extension contracture of the knee.

    PubMed

    Liu, H X; Wen, H; Hu, Y Z; Yu, H C; Pan, X Y

    2014-05-01

    To release extension contracture of the knee, the authors used a minimally invasive technique: percutaneous quadriceps tendon pie-crusting release. Percutaneous pie-crusting release was performed using an 18-gauge needle to puncture the stiff fibrous band of the distal and lateral quadriceps tendon under maximum knee flexion. Quadriceps contracture was gradually released by multiple needle punctures. A knee brace was prescribed for one week and knee flexion exercises were performed on the first postoperative day. This technique was performed in seven post-traumatic stiff knees and five stiff total knee arthroplasties. Mean maximum flexion increased from 37° preoperatively to 50° after arthrolysis and 107(o) after pie-crusting. At a mean follow-up of eight months, mean maximum flexion was 103°. There were no major complications. The technique of quadriceps tendon pie-crusting release is a simple, minimally invasive and effective treatment for knee extension contracture.

  6. 49 CFR 40.395 - Can you settle a PIE proceeding?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.395 Can you settle a PIE proceeding? At any time before the Director's decision, you and the initiating official can, with the...

  7. SNPs in PTGS2 and LTA Predict Pain and Quality of Life in Long Term Lung Cancer Survivors

    PubMed Central

    Rausch, Sarah M.; Gonzalez, Brian D.; Clark, Matthew M.; Patten, Christi; Felten, Sara; Liu, Heshan; Li, Yafei; Sloan, Jeff; Yang, Ping

    2015-01-01

    PURPOSE Lung cancer survivors report the lowest quality of life relative to other cancer survivors. Pain is one of the most devastating, persistent, and incapacitating symptoms for lung cancer survivors. Prevalence rates vary with 80–100% of survivors experiencing cancer pain and healthcare costs are five times higher in cancer survivors with uncontrolled pain. Cancer pain often has a considerable impact on quality of life among cancer patients and cancer survivors. Therefore, early identification, and treatment is important. Although recent studies have suggested a relationship between single nucleotide polymorphisms (SNPs) in several cytokine and inflammation genes with cancer prognosis, associations with cancer pain are not clear. Therefore, the primary aim of this study was to identify SNPs related to pain in long term lung cancer survivors. PATIENTS AND METHODS Participants were enrolled in the Mayo Clinic Lung Cancer Cohort upon diagnosis of their lung cancer. 1149 Caucasian lung cancer survivors, (440 surviving < 3 years; 354 surviving 3–5 years; and 355 surviving> 5 years) completed study questionnaires and had genetic samples available. Ten SNPS from PTGS2 and LTA genes were selected based on the serum literature. Outcomes included pain, and quality of life as measured by the SF-8. RESULTS Of the 10 SNPs evaluated in LTA and PTGS2 genes, 3 were associated with pain severity (rs5277; rs1799964), social function (rs5277) and mental health (rs5275). These results suggested both specificity and consistency of these inflammatory gene SNPs in predicting pain severity in long term lung cancer survivors. CONCLUSION These results provide support for genetic predisposition to pain severity and may aid in identification of lung cancer survivors at high risk for morbidity and poor QOL. PMID:22464751

  8. Report on FY16 Low-dose Metal Fuel Irradiation and PIE

    SciTech Connect

    Edmondson, Philip D.

    2016-09-01

    This report gives an overview of the efforts into the low-dose metal fuel irradiation and PIE as part of the Fuel Cycle Research & Development (FCRD) Advanced Fuels Campaign (AFC) milestone M3FT-16OR020303031. The current status of the FCT and FCRP irradiation campaigns are given including a description of the materials that have been irradiated, analysis of the passive temperature monitors, and the initial PIE efforts of the fuel samples.

  9. Heat and Ice in Sermilik Fjord: Novel Observational Techniques Using PIES

    NASA Astrophysics Data System (ADS)

    Andres, M.; Straneo, F.; Sutherland, D.

    2014-12-01

    A 1-year pilot experiment using pressure-sensor-equipped inverted echo sounders (PIES) was conducted in Sermilik Fjord in eastern Greenland to test non-traditional methods for measuring the time-varying
heat content in high-latitude seas, shelves, and fjords and for detecting the presence of ice. PIES, which are installed on the seafloor below the reach of destructive iceberg keels, present
a promising and inexpensive way to improve understanding of fjord dynamics and shelf-fjord interactions and will increase long-term monitoring capabilities in high latitudes where
remoteness and harsh conditions hamper traditional in situ observation techniques. The use
of PIES to characterize variability at high latitudes is a novel application of an existing
technology, but rests on the same principle as the traditional blue-water uses for PIES: due
to the dependence of sound speed on temperature, the surface-to-bottom round-trip acoustic-travel-time associated with reflections between the PIES and the air-sea interface is an excellent proxy
for heat content in the intervening water column. Furthermore, since reflections from seawater-ice interfaces are also detected when ice
is present, PIES provide a means to characterize the ice component in high-latitude systems. The PIES deployed in Sermilik Fjord (August 2011 - September 2012) resolved changes in heat content at scales ranging from hourly to seasonal. Furthermore, during winter, the PIES logged about 300 iceberg detections and recorded a 2-week period of land-fast ice cover in March. The deepest icebergs in the fjord were found to have keel depths reaching to ~350 m and iceberg speeds averaged about 0.2 m/s but were as high as 0.5 m/s.

  10. An Assessment of ORNL PIE Capabilities for the AGR Program Capsule Post Irradiation Examination

    SciTech Connect

    Morris, Robert Noel

    2006-09-01

    ORNL has facilities and experienced staff that can execute +the Advanced Gas Reactor (AGR) Post Irradiation Examination (PIE) task. While the specific PIE breakdown needs to be more formally defined, the basic outline is clear and the existing capabilities can be assessed within the needs of the tasks defined in the program plan. A one-to-one correspondence between the program plan tasks and the current ORNL PIE status was conducted and while some shortcomings were identified, the general capability is available. Specific upgrade needs were identified and reviewed. A path forward was formulated. Building 3525 is available for this work and this building is currently receiving renewed attention from management so that it will be in good working order prior to the expected PIE start date. This building is equipped with the tools necessary for PIEs of this nature, but the long hiatus in coated particle fuel work has left it with aging analysis tools. This report identified several of these tools and rough estimates of what would be required to update and replace them. In addition, other ORNL buildings are available to support Building 3525 in specialized tasks along with the normal laboratory infrastructure. Before the AGR management embarks on any equipment development effort, the PIE tasks should be updated against current program (modeling and data) needs and better defined so that the items to be measured, their measurement uncertainties, and thru-put needs can be reviewed. A Data Task Matrix (DTM) should be prepared so that the program data needs can be compared against the identified PIE tasks and what is practical in the hot cell environment to make sure nothing is overlooked. Finally, thought should be given to the development of standardized equipment designs between sites to avoid redundant design efforts and different measurement techniques. This is a potentially cost saving effort that can also avoid data inconsistencies.

  11. Growth of Staphylococcus aureus MF 31 on the Top and Cut Surfaces of Southern Custard Pies

    PubMed Central

    Preonas, D. L.; Nelson, A. I.; Ordal, Z. John; Steinberg, M. P.; Wei, L. S.

    1969-01-01

    A Staphylococcus strain was inoculated on the top and cut surfaces of freshly baked Southern custard pies which were then packaged in a pasteboard carton and held at 30 C. Daily plate counts of surface sections 0.3 inch (0.76 cm) in thickness were made. The top surface inoculum showed a 24-hr lag time. This was due to the protective action of a top cakelike layer as shown by homogenization of the mix and coating of the surface. Substitution of all sweeteners with dextrose completely inhibited growth on the top surface. Further addition of dextrose to lower water activity (Aw) to 0.9 prevented growth on the cut surface as well, but such pies were organoleptically unacceptable. Growth on the top surface could also be prevented by 80 μg of undissociated sorbic acid per g in combination with 100 μg of undissociated propionic acid per g in the baked pie. Growth on the cakelike top surface was always retarded longer than on the cut surface provided the packaging allowed evaporation of surface moisture. Reducing the Aw of a different type of cream pie to 0.907 prevented top surface growth. It was concluded that baked cream pies with a cakelike top layer could be marketed with a “refrigerate after opening” label, provided the package maintains the moisture gradient caused by the surface skin and either a combination of 80 μg of undissociated sorbic acid per g and 100 μg undissociated propionic acid per g is present in the baked pie or the Aw of the baked pie is 0.920 or lower. Images PMID:5803631

  12. PIE: an online prediction system for protein-protein interactions from text.

    PubMed

    Kim, Sun; Shin, Soo-Yong; Lee, In-Hee; Kim, Soo-Jin; Sriram, Ram; Zhang, Byoung-Tak

    2008-07-01

    Protein-protein interaction (PPI) extraction has been an important research topic in bio-text mining area, since the PPI information is critical for understanding biological processes. However, there are very few open systems available on the Web and most of the systems focus on keyword searching based on predefined PPIs. PIE (Protein Interaction information Extraction system) is a configurable Web service to extract PPIs from literature, including user-provided papers as well as PubMed articles. After providing abstracts or papers, the prediction results are displayed in an easily readable form with essential, yet compact features. The PIE interface supports more features such as PDF file extraction, PubMed search tool and network communication, which are useful for biologists and bio-system developers. The PIE system utilizes natural language processing techniques and machine learning methodologies to predict PPI sentences, which results in high precision performance for Web users. PIE is freely available at http://bi.snu.ac.kr/pie/.

  13. Theoretical modeling of optical properties of Ag8 and Ag14 silver clusters embedded in an LTA sodalite zeolite cavity.

    PubMed

    Cuong, Ngo Tuan; Nguyen, Hue Minh Thi; Nguyen, Minh Tho

    2013-10-07

    Optical properties of silver Ag(n) nanoclusters are demonstrated to be dependent on their size, structure and charge state. It is found that when being contained in the sodalite cavity of LTA zeolite the tetradecanuclear hexacation silver cluster Ag14(6+) is stable. Its lower-lying states and optical spectrum are theoretically determined using the quantum chemical TD-DFT method. Its ground state possesses an outer-shell electron configuration of A1g(2)T2g(6) mimicking the s(2)p(6) valence of noble gas atoms. These frontier orbitals are constructed from 5s,5p(Ag)-AOs with contributions from framework oxygen atoms. Light absorption of Ag14(6+) embedded in the sodalite cage which is characterized by strong peaks centered at 331 and 476 nm (transitions 5s,p(Ag) → 5s,p(Ag)) leads to much longer wavelength emission. The sodalite cage, as a container, stabilizes the central Ag14(6+) cluster by electrostatic attraction. The absorption spectrum of the isovalent neutral Ag8 cluster embedded inside the same sodalite cavity is also simulated using TD-DFT and CASPT2 methods. This absorption spectrum which is similar to that of the Ag14(6+) cluster has two absorption bands in the near UV and visible regions.

  14. Personalized Integrated Educational System (PIES) for the Learner-Centered Information-Age Paradigm of Education: A Study to Improve the Design of the Functions and Features of PIES

    ERIC Educational Resources Information Center

    Dutta, Pratima

    2013-01-01

    The Personalized Integrated Educational System (PIES) design theory is a design recommendation regarding the function and features of Learning Managements Systems (LMS) that can support the information-age learner-centered paradigm of education. The purpose of this study was to improve the proposed functions and features of the PIES design theory…

  15. Asymmetric enrichment of PIE-1 in the Caenorhabditis elegans zygote mediated by binary counterdiffusion.

    PubMed

    Daniels, Brian R; Perkins, Edward M; Dobrowsky, Terrence M; Sun, Sean X; Wirtz, Denis

    2009-02-23

    To generate cellular diversity in developing organisms while simultaneously maintaining the developmental potential of the germline, germ cells must be able to preferentially endow germline daughter cells with a cytoplasmic portion containing specialized cell fate determinants not inherited by somatic cells. In Caenorhabditis elegans, germline inheritance of the protein PIE-1 is accomplished by first asymmetrically localizing the protein to the germplasm before cleavage and subsequently degrading residual levels of the protein in the somatic cytoplasm after cleavage. Despite its critical involvement in cell fate determination, the enrichment of germline determinants remains poorly understood. Here, combining live-cell fluorescence methods and kinetic modeling, we demonstrate that the enrichment process does not involve protein immobilization, intracellular compartmentalization, or localized protein degradation. Instead, our results support a heterogeneous reaction/diffusion model for PIE-1 enrichment in which the diffusion coefficient of PIE-1 is reversibly reduced in the posterior, resulting in a stable protein gradient across the zygote at steady state.

  16. Principal angles separate subject illumination spaces in YDB and CMU-PIE.

    PubMed

    Beveridge, J Ross; Draper, Bruce A; Chang, Jen-Mei; Kirby, Michael; Kley, Holger; Peterson, Chris

    2009-02-01

    The theory of illumination subspaces is well developed and has been tested extensively on the Yale Face Database B (YDB) and CMU-PIE (PIE) data sets. This paper shows that if face recognition under varying illumination is cast as a problem of matching sets of images to sets of images, then the minimal principal angle between subspaces is sufficient to perfectly separate matching pairs of image sets from nonmatching pairs of image sets sampled from YDB and PIE. This is true even for subspaces estimated from as few as six images and when one of the subspaces is estimated from as few as three images if the second subspace is estimated from a larger set (10 or more). This suggests that variation under illumination may be thought of as useful discriminating information rather than unwanted noise.

  17. Progress on accelerated calculation of 3D MHD equilibrium with the PIES code

    NASA Astrophysics Data System (ADS)

    Raburn, Daniel; Reiman, Allan; Monticello, Donald

    2016-10-01

    Continuing progress has been made in accelerating the 3D MHD equilibrium code, PIES, using an external numerical wrapper. The PIES code (Princeton Iterative Equilibrium Solver) is capable of calculating 3D MHD equilibria with islands. The numerical wrapper has been demonstrated to greatly improve the rate of convergence in numerous cases corresponding to equilibria in the TFTR device where magnetic islands are present; the numerical wrapper makes use of a Jacobian-free Newton-Krylov solver along with adaptive preconditioning and a sophisticated subspace-restricted Levenberg backtracking algorithm. The wrapper has recently been improved by automation which combines the preexisting backtracking algorithm with insights gained from the stability of the Picard algorithm traditionally used with PIES. Improved progress logging and stopping criteria have also been incorporated in to the numerical wrapper.

  18. Contributions from Particles in Europe (PiE) 2010, Villefranche-sur-Mer, France: an introduction

    NASA Astrophysics Data System (ADS)

    Mikkelsen, Ole A.; Chami, Malik; Doxaran, David

    2012-04-01

    This special issue of Geo-Marine Letters presents selected contributions from the international conference Particles in Europe (PiE) 2010 organized by Sequoia Scientific, Inc., and the Laboratoire d'Océanographie de Villefranche (LOV) on 15-17 November 2010 in Villefranche-sur-Mer, France, and guest-edited by Ole Mikkelsen, Malik Chami and David Doxaran. PiE was initiated in 2008, in order to promote and further our understanding of the importance of suspended particulate matter (SPM) for a very wide range of processes in the aquatic environment—from optics and acoustics, over sediment transport, to the global carbon balance. The papers in this special issue are in particular concerned with the interaction between SPM and water optical properties, as well as how to use optical proxy measurements to understand SPM processes. The next PiE conference is scheduled for 17-19 October 2012 in Barcelona, Spain.

  19. Gain and saturation parameters of a multikilowatt PIE CO2 laser

    NASA Astrophysics Data System (ADS)

    Nikumb, S. K.; Seguin, H. J. J.; Seguin, V. A.; Reshef, H.

    1987-07-01

    Details of an experimental investigation of the small signal gain and saturation parameter of a 10 kW CW photoinitiated, impulse-enhanced, electrically excited (PIE) CO2 laser are presented. Measurements were made as a function of several device operational conditions, such as gas pressure, input electrical power, pulser ionization, and flow velocity. Gain profiles were also obtained, both from anode to cathode, and in the direction of gas flow. The results document the effectiveness of the PIE excitation technique, while providing detailed information on the gain medium. Such data are essential to the design of an efficient optical extraction system.

  20. The application of the Galerkin method to solving PIES for Laplace's equation

    NASA Astrophysics Data System (ADS)

    Bołtuć, Agnieszka; Zieniuk, Eugeniusz

    2016-06-01

    The paper presents the application of the Galerkin method to solving the parametric integral equation system (PIES) on the example of Laplace's equation. The main aim of the paper is the analysis of the effectiveness of two methods for PIES solving: the collocation method and the Galerkin method. Researches were performed on two examples with analytical solutions. Tests concern mainly the accuracy of obtained numerical solutions and their stability. For both analyzed methods calculations were made with the various number of expressions in the approximation series, whilst in the collocation method two variants of the arrangement of collocation points were considered. We also compared the complexity of both methods using the execution time.

  1. Is the pie-crusting technique safe for MCL release in varus deformity correction in total knee arthroplasty?

    PubMed

    Meneghini, R Michael; Daluga, Andrew T; Sturgis, Lindsey A; Lieberman, Jay R

    2013-09-01

    Established for lateral release in TKA, the pie-crusting technique has not been studied for the medial collateral ligament (MCL). In cadaveric knees the MCL was release with a pie-crusting technique in one and traditional technique in the contralateral knee. Along with a control group, each MCL was subjected to mechanical testing. The stiffness, force and stress required to cause ligament elongation were less in the pie-crusting group (p < 0.05) compared to the control group, but were not statistically different than the traditional group. The pie-crusting group demonstrated a characteristic "stair-step" failure mode at the joint line, whereas the traditional group failed elastically at the tibial insertion. MCL pie-crusting is likely technique dependent since failure occurs within the ligament itself and further study is warranted.

  2. Giant Paperclip Necklaces, Soup-Can Rings and Cherry-Pie Hats

    ERIC Educational Resources Information Center

    Winters, Laurel A.

    2011-01-01

    In this article, the author describes an art project inspired by the wearable sculpture art created by artist Marjorie Schick. Students used wallpaper paste and newspapers to create papier-mache for a mountain hat, a cherry-pie mask/hat, a "dress" shoe and a Cubistic mask. Cardboard was used in many of these things, in addition to being used as…

  3. Slicing the Attitude Pie: A Validity and Reliability Study of a New Attitude Assessment Technique.

    ERIC Educational Resources Information Center

    Lull, James T.; Cappella, Joseph N.

    This paper introduces a new measure of attitude, the "attitude pie," which attempts to separate true neutrality from degree of indifference while providing an evaluation score on the issue being judged. A large reliability-validity study involving ten attitude traits, four different methods, and over one hundred subjects at three different times…

  4. EZDRAW. An Interactive Computer Graphics Program to Design Bar, Line, or Pie Graphs.

    DTIC Science & Technology

    1982-12-01

    Figure Page 1 EZDRAW System Configuration . . . . . . . . . )15 2 Representation of EZDRAW Levels by Menus . .16 * 3 GRAFMAKER Design...Graph . . . .. . . .. 47 8 EZDRAW Pie Graph ... 48 * 9 Main Module .. . . . . . .. B-2 10 Starting EZDR A’. . .. . . . .. B- 3 11 Initializing EZDRAW...Design Attributes . . . . A- 3 II EZDRAW Variables .......... ........ C-1 III EZDRAW Subroutines ..... .............. .D-1 IV DI-3000 Subroutines

  5. Preschool Instruction for the Exceptional (PIE) Project Report: 1976-1977.

    ERIC Educational Resources Information Center

    Ciccoricco, Edward A.; And Others

    Presented is the 1976-77 project report containing descriptions and evaluations of the five accomplished goals of the Preschool Instruction for the Exceptional (PIE) program which has provided services for 54 New Jersey students (3 to 5-years old). Described and discussed are the following objectives: (1) identification and diagnosis of preschool…

  6. Reflections on "Petit Battement sur le Cou de Pied": Is It Still Relevant?

    ERIC Educational Resources Information Center

    Paskevska, Anna

    2007-01-01

    This article presents multiple perspectives of "petit battement sur le cou de pied". These perspectives include historical, biomechanical, and pedagogic points of view. The article offers useful information for ballet specialists and applied research studies aimed at ballet pedagogy. (Contains 2 tables and 5 figures.)

  7. 49 CFR 40.375 - How does the initiating official start a PIE proceeding?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false How does the initiating official start a PIE proceeding? 40.375 Section 40.375 Transportation Office of the Secretary of Transportation PROCEDURES FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.375 How does the initiating official start a...

  8. Bars, Lines, & Pies: A Graphing Skills Program. Expect the Unexpected with Math[R

    ERIC Educational Resources Information Center

    Actuarial Foundation, 2013

    2013-01-01

    "Bars, Lines, & Pies" is a dynamic math program designed to build graphing skills in students, while also showing them the relevance of math in their lives. Developed by The Actuarial Foundation along with Scholastic, the graphing lessons and activities involve engaging, real-world examples about the environment and recycling. In these lessons,…

  9. Mnemonic Device for Relating the Eight Thermodynamic State Variables: The Energy Pie

    ERIC Educational Resources Information Center

    Fieberg, Jeffrey E.; Girard, Charles A.

    2011-01-01

    A mnemonic device, the energy pie, is presented that provides relationships between thermodynamic potentials ("U," "H," "G," and "A") and other sets of variables that carry energy units, "TS" and "PV." Methods are also presented in which the differential expressions for the potentials and the corresponding Maxwell relations follow from the energy…

  10. Oxidative stress in pied flycatcher (Ficedula hypoleuca) nestlings from metal contaminated environments in northern Sweden

    SciTech Connect

    Berglund, A.M.M. Sturve, J.; Foerlin, L.; Nyholm, N.E.I.

    2007-11-15

    Metals have been shown to induce oxidative stress in animals. One of the most metal polluted terrestrial environments in Sweden is the surroundings of a sulfide ore smelter plant located in the northern part of the country. Pied flycatcher nestlings (Ficedula hypoleuca) that grew up close to the industry had accumulated amounts of arsenic, cadmium, mercury, lead, iron and zinc in their liver tissue. The aim of this study was to investigate if pied flycatcher nestlings in the pollution gradient of the industry were affected by oxidative stress using antioxidant molecules and enzyme activities. The antioxidant assays were also evaluated in search for useful biomarkers in pied flycatchers. This study indicated that nestlings in metal contaminated areas showed signs of oxidative stress evidenced by up regulated hepatic antioxidant defense given as increased glutathione reductase (GR) and catalase (CAT) activities and slightly but not significantly elevated lipid peroxidation and glutathione-S-transferase (GST) activities. Stepwise linear regression indicated that lipid peroxidation and CAT activities were influenced mostly by iron, but iron and lead influenced the CAT activity to a higher degree. Positive relationships were found between GST and lead as well as GR activities and cadmium. We conclude that GR, CAT, GST activities and lipid peroxidation levels may function as useful biomarkers for oxidative stress in free-living pied flycatcher nestlings exposed to metal contaminated environments.

  11. Reading: Making It Personal Again--Now Serving PIE to Hungry Readers

    ERIC Educational Resources Information Center

    Hobbs, Nancy; Oleynik, Myra; Sacco, Kristen

    2009-01-01

    Something wonderful happens when children are asked to choose their own books and are given ample time to read and discuss them. They become hungry readers with an appetite for books! This simple strategy was the basis for developing the program known as PIE (Personalized Independent Enrichment) and its recipe for reading success. The goal of the…

  12. International Workshop on Characterization and PIE Needs for Fundamental Understanding of Fuels Performance and Safety

    SciTech Connect

    Not Listed

    2011-12-01

    The International Workshop on Characterization and PIE Needs to Support Science-Based Development of Innovative Fuels was held June 16-17, 2011, in Paris, France. The Organization for Economic Co-operation and Development (OECD), Nuclear Energy Agency (NEA) Working Party on the Fuel Cycle (WPFC) sponsored the workshop to identify gaps in global capabilities that need to be filled to meet projected needs in the 21st century. First and foremost, the workshop brought nine countries and associated international organizations, together in support of common needs for nuclear fuels and materials testing, characterization, PIE, and modeling capabilities. Finland, France, Germany, Republic of Korea, Russian Federation, Sweden, Switzerland, United Kingdom, United States of America, IAEA, and ITU (on behalf of European Union Joint Research Centers) discussed issues and opportunities for future technical advancements and collaborations. Second, the presentations provided a base level of understanding of current international capabilities. Three main categories were covered: (1) status of facilities and near term plans, (2) PIE needs from fuels engineering and material science perspectives, and (3) novel PIE techniques being developed to meet the needs. The International presentations provided valuable data consistent with the outcome of the National Workshop held in March 2011. Finally, the panel discussion on 21st century PIE capabilities, created a unified approach for future collaborations. In conclusion, (1) existing capabilities are not sufficient to meet the needs of a science-based approach, (2) safety issues and fuels behavior during abnormal conditions will receive more focus post-Fukushima; therefore we need to adopt our techniques to those issues, and (3) International collaboration is needed in the areas of codes and standards development for the new techniques.

  13. Combining MFD and PIE for accurate single-pair Förster resonance energy transfer measurements.

    PubMed

    Kudryavtsev, Volodymyr; Sikor, Martin; Kalinin, Stanislav; Mokranjac, Dejana; Seidel, Claus A M; Lamb, Don C

    2012-03-01

    Single-pair Förster resonance energy transfer (spFRET) experiments using single-molecule burst analysis on a confocal microscope are an ideal tool to measure inter- and intramolecular distances and dynamics on the nanoscale. Different techniques have been developed to maximize the amount of information available in spFRET burst analysis experiments. Multiparameter fluorescence detection (MFD) is used to monitor a variety of fluorescence parameters simultaneously and pulsed interleaved excitation (PIE) employs direct excitation of the acceptor to probe its presence and photoactivity. To calculate accurate FRET efficiencies from spFRET experiments with MFD or PIE, several calibration measurements are usually required. Herein, we demonstrate that by combining MFD with PIE information regarding all calibration factors as well as an accurate determination of spFRET histograms can be performed in a single measurement. In addition, the quality of overlap of the different detection volumes as well as the detection of acceptor photophysics can be investigated with MFD-PIE. Bursts containing acceptor photobleaching can be identified and excluded from further investigation while bursts that contain FRET dynamics are unaffected by this analysis. We have employed MFD-PIE to accurately analyze the effects of nucleotides and substrate on the interdomain separation in DnaK, the major bacterial heat shock protein 70 (Hsp70). The interdomain distance increases from 47 Å in the ATP-bound state to 84 Å in the ADP-bound state and slightly contracts to 77 Å when a substrate is bound. This is in contrast to what was observed for the mitochondrial member of the Hsp70s, Ssc1, supporting the notion of evolutionary specialization of Hsp70s for different cellular functions in different organisms and cell organelles.

  14. prepare_taxa_charts.py: A Python program to automate generation of publication ready taxonomic pie chart images from QIIME.

    PubMed

    Lakhujani, Vijay; Badapanda, Chandan

    2017-06-01

    QIIME (Quantitative Insights Into Microbial Ecology) is one of the most popular open-source bioinformatics suite for performing metagenome, 16S rRNA amplicon and Internal Transcribed Spacer (ITS) data analysis. Although, it is very comprehensive and powerful tool, it lacks a method to provide publication ready taxonomic pie charts. The script plot_taxa_summary.py bundled with QIIME generate a html file and a folder containing taxonomic pie chart and legend as separate images. The images have randomly generated alphanumeric names. Therefore, it is difficult to associate the pie chart with the legend and the corresponding sample identifier. Even if the option to have the legend within the html file is selected while executing plot_taxa_summary.py, it is very tedious to crop a complete image (having both the pie chart and the legend) due to unequal image sizes. It requires a lot of time to manually prepare the pie charts for multiple samples for publication purpose. Moreover, there are chances of error while identifying the pie chart and legend pair due to random alphanumeric names of the images. To bypass all these bottlenecks and make this process efficient, we have developed a python based program, prepare_taxa_charts.py, to automate the renaming, cropping and merging of taxonomic pie chart and corresponding legend image into a single, good quality publication ready image. This program not only augments the functionality of plot_taxa_summary.py but is also very fast in terms of CPU time and user friendly.

  15. Synthesis and characterization of LTA nanozeolite using barley husk silica: Mercury removal from standard and real solutions

    SciTech Connect

    Azizi, Seyed Naser; Dehnavi, Ahmad Roozbehani; Joorabdoozha, Amir

    2013-05-15

    Highlights: ► Silica extraction from barley husk with high purity for the synthesis of A nanozeolite. ► Free template A nanozeolite synthesized via new source of silica at low temperature. ► Optimization of SiO{sub 2}/Al{sub 2}O{sub 3}, Na{sub 2}O/SiO{sub 2} ratios, temperature and time of the synthesis. ► Utilizing of synthesized A nanozeolite for mercury removal from aqueous solutions. ► Mercury removal at optimized pH, contact time and adsorbent dose from real solution. - Abstract: In this study, synthesized Lined Type A (LTA) nanozeolite from barley husk silica (BHS) was used for mercury removal from standard and real aqueous solutions. The BHS in amorphous phase with 80% purity was extracted from barley husk ash (BHA), and used effectively as a new source of silica for the synthesis of NaA nanozeolite. The NaA nanocrystal in pure phase has been synthesized at low temperature, without adding any organic additives. The effects of heating time, reaction temperature, SiO{sub 2}/Al{sub 2}O{sub 3}, and Na{sub 2}O/SiO{sub 2} mole ratios on the crystallization of NaA nanozeolite were studied. The adsorption capacity of mercury (II) was studied as a function of pH, contact time, and amount of adsorbent. The crystallization of NaA nanozeolite from BHS was characterized by X-ray diffraction (XRD), X-ray fluorescence (XRF), scanning electron microscopy (SEM), energy-dispersive X-ray (EDX), Brunauer–Emmett–Teller (BET), and FTIR techniques. Moreover, concentration of Hg{sup 2+} ions in the aqueous solutions was analyzed by hydride generation atomic absorption spectroscopy method (HG-AAS). The standard and real samples analysis showed that NaA nanozeolite is capable of Hg{sup 2+} ions removal from the aqueous solutions. Efficiency of mercury (II) adsorption from real solutions onto the nano-sized NaA zeolite was 98%.

  16. Analysis of migration rate and chemotaxis of human adipose-derived mesenchymal stem cells in response to LPS and LTA in vitro.

    PubMed

    Herzmann, Nicole; Salamon, Achim; Fiedler, Tomas; Peters, Kirsten

    2016-03-15

    Mesenchymal stem cells (MSC) are able to stimulate the regeneration of injured tissue. Since bacterial infections are common complications in wound healing, bacterial pathogens and their components come into direct contact with MSC. The interaction with bacterial structures influences the proliferation, differentiation and migratory activity of the MSC, which might be of relevance during regeneration. Studies on MSC migration in response to bacterial components have shown different results depending on the cell type. Here, we analyzed the migration rate and chemotaxis of human adipose-derived MSC (adMSC) in response to the basic cell-wall components lipopolysaccharide (LPS) of Gram-negative bacteria and lipoteichoic acid (LTA) of Gram-positive bacteria in vitro. To this end, we used transwell and scratch assays, as well as a specific chemotaxis assay combined with live-cell imaging. We found no significant influence of LPS or LTA on the migration rate of adMSC in transwell or scratch assays. Furthermore, in the µ-slide chemotaxis assay, the stimulation with LPS did not exert any chemotactic effect on adMSC.

  17. Comparison between urinary 11-dehydrothromboxane B2 detection and platelet Light Transmission Aggregometry (LTA) assays for evaluating aspirin response in elderly patients with coronary artery disease.

    PubMed

    Liu, Tengfei; Zhang, Jingwei; Chen, Xiahuan; Feng, Xueru; Fu, Sidney W; McCaffrey, Timothy A; Liu, Meilin

    2015-10-15

    Aspirin is widely used in the primary and secondary prevention of cardiovascular diseases. The aim of our study was to compare between two established methods of aspirin response, urinary 11-dehydrothromboxane B2 (11dhTXB2) and platelet Light Transmission Aggregometry (LTA) assays in elderly Chinese patients with coronary artery disease (CAD), and to investigate the clinical significance of both methods in predicting cardiovascular events. Urinary 11dhTxB2 assay and arachidonic acid-induced (AA, 0.5mg/ml) platelet aggregation by Light Transmission Aggregometry (LTAAA) assay were measured to evaluate aspirin responses. High-on aspirin platelet reactivity (HAPR) was defined as urinary 11dhTxB2>1500pg/mg or AA-induced platelet aggregation≥15.22%-the upper quartile of our enrolled population. The two tests showed a poor correlation for aspirin inhibition (r=0.063) and a poor agreement in classifying HAPR (kappa=0.053). With a mean follow-up time of 12months, cardiovascular events occurred more frequently in HAPR patients who were diagnosed by LTA assay as compared with no-HAPR patients (22.5% versus 10.6%, P=0.039, OR=2.45, 95% CI=1.06-5.63). However, the HAPR status, as determined by urinary 11dTXB2 measurement, did not show a significant correlation with outcomes.

  18. Precision Information Environment (PIE) for International Safeguards: Pre-Demonstration Development Use Cases

    SciTech Connect

    Gastelum, Zoe N.; Henry, Michael J.

    2013-11-13

    In FY2013, the PIE International Safeguards team demonstrated our development progress to U.S. Department of Energy (DOE) staff from the Office of Nonproliferation and International Security (NA-24, our client) and the Office of Defense Nuclear Nonproliferation Research and Development (NA-22). Following the demonstration, the team was asked by our client to complete additional development prior to a planned demonstration at the International Atomic Energy Agency (IAEA), scheduled tentatively for January or spring of 2014. The team discussed four potential areas for development (in priority order), and will develop them as time and funding permit prior to an IAEA demonstration. The four capability areas are: 1. Addition of equipment manuals to PIE-accessible files 2. Optical character recognition (OCR) of photographed text 3. Barcode reader with information look-up from a database 4. Add Facilities to Data Model 5. Geospatial capabilities with information integration Each area will be described below in a use case.

  19. Arthroscopic trans-portal deep medial collateral ligament pie-crusting release.

    PubMed

    Atoun, Ehud; Debbi, Ronen; Lubovsky, Omri; Weiler, Andreas; Debbi, Eytan; Rath, Ehud

    2013-02-01

    Arthroscopic treatments of meniscal injuries of the knee are among the most common orthopaedic procedures performed. Adequate visualization of the posterior horn of the medial meniscus might be challenging, especially in patients with tight medial compartments. In these cases instrument manipulation in an attempt to reach the posterior horn of the meniscus can cause an iatrogenic chondral injury because of the narrow medial joint space. A transcutaneous medial collateral ligament (MCL) pie-crusting release facilitates expansion of the medial joint space in a case of a tight medial compartment. Nevertheless, it might cause injury to the superficial MCL, infection, and pain and injury to the saphenous nerve because of multiple needle punctures of the skin. We describe an inside-out, arthroscopic deep MCL pie-crusting release, which allows access to the medial meniscus through the anterior approach to provide good visualization of the footprint and sufficient working space.

  20. Tunable PIE and synchronized gating detections by FastFLIM for quantitative microscopy measurements of fast dynamics of single molecules

    NASA Astrophysics Data System (ADS)

    Sun, Yuansheng; Coskun, Ulas; Ferreon, Allan Chris; Barbieri, Beniamino; Liao, Shih-Chu Jeff

    2016-03-01

    The crosstalk between two fluorescent species causes problems in fluorescence microscopy imaging, especially for quantitative measurements such as co-localization, Förster resonance energy transfer (FRET), fluorescence cross correlation spectroscopy (FCCS). In laser scanning confocal microscopy, the lasers can be switched on and off by acousto-optic tunable filters (AOTF) in the microsecond scale for alternative line scanning in order to avoid the crosstalk while minimizing the time delay between two lasers on the same pixel location. In contrast, the pulsed interleaved excitation (PIE) technique synchronizes two pulsed lasers of different wavelengths in the nanosecond scale to enable measuring superfast dynamics of two fluorescent species simultaneously and yet quantitatively without the crosstalk contamination. This feature is critical for many cell biology applications, e.g. accurate determination of stoichiometry in FRET measurements for studying protein-protein interactions or cell signal events, detection of weaker bindings in FCCS by eliminating the false cross correlation due to the crosstalk. The PIE has been used with the time correlated single photon counting (TCSPC) electronics. Here, we describe a novel PIE development using the digital frequency domain (DFD) technique -- FastFLIM, which provides tunable PIE setups and synchronized gating detections, tailored and optimized to specific applications. A few PIE setups by FastFLIM and measurement examples are described. Combined with the sensitivity of Alba and Q2 systems, the PIE allowed us to quantitatively measure the fast dynamics of single molecules.

  1. Parallelization of LSODE in PIES Using NVIDIA's CUDA Architecture for GPGPU

    NASA Astrophysics Data System (ADS)

    Thompson, Paul; Ethier, Stephane

    2009-11-01

    The Princeton Iterative Equilibrium Solver (PIES) is a powerful tool for computing three dimensional MHD equilibria, without making assumptions about the form of the magnetic field. Part of its strength comes from its ability to handle equilibria with islands and stochastic regions. However, a high-resolution PIES calculation often takes several hours to complete, spending most of its time in the Livermore Solver for Ordinary Differential Equations (LSODE) to follow field-line trajectories. This work examines the feasibility of speeding up these calculations by taking advantage of the parallel computing resources of programmable Graphic Processor Units (GPUs). To this end, the LSODA variant version of LSODE is converted to NVIDIA's C for CUDA application programming interface and tested against its original Fortran version on an NVIDIA Tesla Cluster. Run times are compared between the serial and parallel versions, with special attention given to different scaling options. The new code is also analyzed for bottlenecks and opportunities for additional speedups, with the ultimate goal of developing a PIES-based MHD solver capable of running between experimental shots.

  2. "Operation Pied Piper": a psychoanalytic narrative of authority in a time of war.

    PubMed

    Farley, Lisa

    2012-01-01

    The evacuation of British children during World War II is read alongside the legend of the "Pied Piper" after which the mass migration was officially named. While virtually every British account of World War II makes mention of the evacuation, most are silent on the question of its ominous title: "Operation Pied Piper." This paper traces the legend's key theme - on influencing and being influenced - as it surfaces in the writing of one child analyst and one social worker charged with the responsibility of leading a family of five hostels for British youth. At a time when Hitler's deadly regime reached unprecedented heights across the Channel, the legend of the "Pied Piper" becomes a highly suggestive metaphor for thinking about D. W. Winnicott and Clare Britton's writing on what authority could mean in the face of leadership gone terribly wrong. Quite another, profoundly intimate loss of leadership haunts their words as well: Sigmund Freud, in exile from Hitler's Europe and leader of the psychoanalytic movement, died in London just weeks after the first wave of Blitz evacuations. It is in this context that Winnicott and Britton articulated a theory of authority that could address the losses of history without at the same time demanding the loss of the mind.

  3. African departure rather than migration speed determines variation in spring arrival in pied flycatchers.

    PubMed

    Ouwehand, Janne; Both, Christiaan

    2017-01-01

    Properly timed spring migration enhances reproduction and survival. Climate change requires organisms to respond to changes such as advanced spring phenology. Pied flycatchers Ficedula hypoleuca have become a model species to study such phenological adaptations of long-distance migratory songbirds to climate change, but data on individuals' time schedules outside the breeding season are still lacking. Using light-level geolocators, we studied variation in migration schedules across the year in a pied flycatcher population in the Netherlands, which sheds light on the ability for individual adjustments in spring arrival timing to track environmental changes at their breeding grounds. We show that variation in arrival dates to breeding sites in 2014 was caused by variation in departure date from sub-Saharan Africa and not by environmental conditions encountered en route. Spring migration duration was short for all individuals, on average 2 weeks. Males migrated ahead of females in spring, while migration schedules in autumn were flexibly adjusted according to breeding duties. Individuals were therefore not consistently early or late throughout the year. In fast migrants like our Dutch pied flycatchers, advancement of arrival to climate change likely requires changes in spring departure dates. Adaptation for earlier arrival may be slowed down by harsh circumstances in winter, or years with high costs associated with early migration.

  4. PIE on Safety-Tested AGR-1 Compact 5-1-1

    SciTech Connect

    Hunn, John D.; Morris, Robert Noel; Baldwin, Charles A.; Montgomery, Fred C.; Gerczak, Tyler J.

    2015-08-01

    Post-irradiation examination (PIE) is being performed in support of tristructural isotropic (TRISO) coated particle fuel development and qualification for High-Temperature Gas-cooled Reactors (HTGRs). AGR-1 was the first in a series of TRISO fuel irradiation experiments initiated in 2006 under the Advanced Gas Reactor (AGR) Fuel Development and Qualification Program; this work continues to be funded by the Department of Energy's Office of Nuclear Energy as part of the Advanced Reactor Technologies (ART) initiative. AGR-1 fuel compacts were fabricated at Oak Ridge National Laboratory (ORNL) in 2006 and irradiated for three years in the Idaho National Laboratory (INL) Advanced Test Reactor (ATR) to demonstrate and evaluate fuel performance under HTGR irradiation conditions. PIE is being performed at INL and ORNL to study how the fuel behaved during irradiation, and to examine fuel performance during exposure to elevated temperatures at or above temperatures that could occur during a depressurized conduction cooldown event. This report summarizes safety testing of irradiated AGR-1 Compact 5-1-1 in the ORNL Core Conduction Cooldown Test Facility (CCCTF) and post-safety testing PIE.

  5. Effect of TNF and LTA polymorphisms on biological markers of response to oxidative stimuli in coal miners: a model of gene-environment interaction

    PubMed Central

    Nadif, R; Jedlicka, A; Mintz, M; Bertrand, J; Kleeberger, S; Kauffmann, F

    2003-01-01

    Introduction: Interaction between genetic background and oxidative environmental stimuli in the pathogenesis of human lung disease has been largely unexplored. Methods: A prospective epidemiological study was undertaken in 253 coal miners. Intermediate quantitative phenotypes of response to oxidant exposure, including erythrocyte glutathione peroxidase (GSH-Px) and catalase activities, were studied. Oxidant exposures studied were smoking habits and cumulative dust exposure assessed by job history and ambient measures. Disease phenotypes included subclinical computed tomography score at the first survey and x ray profusion grades twice, five years apart, to assess established coal workers' pneumoconiosis (CWP). Miners were genotyped for common functional polymorphisms in the gene for tumour necrosis factor α (TNF) and lymphotoxin α (LTA), two proinflammatory cytokines that have been implicated in the pathogenesis of chronic lung diseases. Results: Regarding gene-environment interaction on intermediate phenotypes, results showed interaction of a promoter polymorphism at the –308 position in TNF with occupational exposure on erythrocyte GSH-Px activity with a significant association in those with high exposure (p=0.003), whereas no association was observed among those with low exposure (interaction p=0.06). Regarding gene intermediate phenotype interaction on clinical outcome, results showed an association of CWP prevalence with an NcoI polymorphism in LTA in those with low catalase activity (p=0.05), whereas no association was observed in those with high activity (interaction p=0.03). No other significant association was observed. Conclusion: The results suggest that interactions of genetic background with environmental exposure and intermediate response phenotypes are important components in the pathogenesis of CWP. PMID:12566517

  6. Inhibition of transcription by the Caenorhabditis elegans germline protein PIE-1: genetic evidence for distinct mechanisms targeting initiation and elongation.

    PubMed

    Ghosh, Dolan; Seydoux, Geraldine

    2008-01-01

    In Caenorhabditis elegans embryos, specification of the germ lineage depends on PIE-1, a maternal protein that blocks mRNA transcription in germline blastomeres. Studies in mammalian cell culture have suggested that PIE-1 inhibits P-TEFb, a kinase that phosphorylates serine 2 in the carboxyl-terminal domain (CTD) repeats of RNA polymerase II during transcriptional elongation. We have tested this hypothesis using an in vivo complementation assay for PIE-1 function. Our results support the view that PIE-1 inhibits P-TEFb using the CTD-like motif YAPMAPT. This activity is required to block serine 2 phosphorylation in germline blastomeres, but unexpectedly is not essential for transcriptional repression or specification of the germline. We find that sequences outside of the YAPMAPT are required to inhibit serine 5 phosphorylation, and that this second inhibitory mechanism is essential for transcriptional repression and specification of the germ lineage. Our results suggest that PIE-1 uses partially redundant mechanisms to block transcription by targeting both the initiation and elongation phases of the transcription cycle.

  7. Detection of rhodopsin dimerization in situ by PIE-FCCS, a time-resolved fluorescence spectroscopy.

    PubMed

    Smith, Adam W

    2015-01-01

    Rhodopsin self-associates in the plasma membrane. At low concentrations, the interactions are consistent with a monomer-dimer equilibrium (Comar et al., J Am Chem Soc 136(23):8342-8349, 2014). At high concentrations in native tissue, higher-order clusters have been observed (Fotiadis et al., Nature 421:127-128, 2003). The physiological role of rhodopsin dimerization is still being investigated, but it is clear that a quantitative assessment is essential to determining the function of rhodopsin clusters in vision. To quantify rhodopsin interactions, I will outline the theory and methodology of a specialized time-resolved fluorescence spectroscopy for measuring membrane protein-protein interactions called pulsed-interleaved excitation fluorescence cross-correlation spectroscopy (PIE-FCCS). The strength of this technique is its ability to quantify rhodopsin interactions in situ (i.e., a live cell plasma membrane). There are two reasons for restricting the scope to live cell membranes. First, the compositional heterogeneity of the plasma membrane creates a complex milieu with thousands of lipid, protein, and carbohydrate species. This makes it difficult to infer quaternary interactions from detergent solubilized samples or construct a model phospholipid bilayer that recapitulates all of the interactions present in native membranes. Second, organizational structure and dynamics is a key feature of the plasma membrane, and fixation techniques like formaldehyde cross-linking and vitrification will modulate the interactions. PIE-FCCS is based on two-color fluorescence imaging with time-correlated single-photon counting (TCSPC) (Becker et al., Rev Sci Instrum 70:1835-1841, 1999). By time-tagging every detected photon, the data can be analyzed as a fluorescence intensity distribution, fluorescence lifetime histogram, or fluorescence (cross-)correlation spectra (FCS/FCCS) (Becker, Advanced time-correlated single-photon counting techniques, Springer, Berlin, 2005). These

  8. Calling Where It Counts: Subordinate Pied Babblers Target the Audience of Their Vocal Advertisements

    PubMed Central

    Humphries, David J.; Finch, Fiona M.; Bell, Matthew B. V.; Ridley, Amanda R.

    2015-01-01

    For territorial group-living species, opportunities to reproduce on the natal territory can be limited by a number of factors including the availability of resources within a territory, access to unrelated individuals, and monopolies on reproduction by dominant group members. Individuals looking to reproduce are therefore faced with the options of either waiting for a breeding opportunity to arise in the natal territory, or searching for reproductive opportunities in non-natal groups. In the cooperatively breeding Southern pied babbler, Turdoides bicolor, most individuals who achieve reproductive success do so through taking up dominant breeding positions within non-natal groups. For subordinate pied babblers therefore, searching for breeding opportunities in non-natal groups is of primary importance as this represents the major route to reproductive success. However, prospecting (where individuals leave the group to search for reproductive opportunities within other groups) is costly and individuals rapidly lose weight when not part of a group. Here we demonstrate that subordinate pied babblers adopt an alternative strategy for mate attraction by vocal advertisement from within their natal territories. We show that subordinates focus their calling efforts on the edges of their territory, and specifically near boundaries with neighbouring groups that have potential breeding partners (unrelated individuals of the opposite sex). In contrast to prospecting, calling individuals showed no body mass loss associated with this behaviour, suggesting that calling from within the group may provide a ‘cheap’ advertisement strategy. Additionally, we show that subordinates use information regarding the composition of neighbouring groups to target the greatest number of potential mating partners. PMID:26177094

  9. Calling Where It Counts: Subordinate Pied Babblers Target the Audience of Their Vocal Advertisements.

    PubMed

    Humphries, David J; Finch, Fiona M; Bell, Matthew B V; Ridley, Amanda R

    2015-01-01

    For territorial group-living species, opportunities to reproduce on the natal territory can be limited by a number of factors including the availability of resources within a territory, access to unrelated individuals, and monopolies on reproduction by dominant group members. Individuals looking to reproduce are therefore faced with the options of either waiting for a breeding opportunity to arise in the natal territory, or searching for reproductive opportunities in non-natal groups. In the cooperatively breeding Southern pied babbler, Turdoides bicolor, most individuals who achieve reproductive success do so through taking up dominant breeding positions within non-natal groups. For subordinate pied babblers therefore, searching for breeding opportunities in non-natal groups is of primary importance as this represents the major route to reproductive success. However, prospecting (where individuals leave the group to search for reproductive opportunities within other groups) is costly and individuals rapidly lose weight when not part of a group. Here we demonstrate that subordinate pied babblers adopt an alternative strategy for mate attraction by vocal advertisement from within their natal territories. We show that subordinates focus their calling efforts on the edges of their territory, and specifically near boundaries with neighbouring groups that have potential breeding partners (unrelated individuals of the opposite sex). In contrast to prospecting, calling individuals showed no body mass loss associated with this behaviour, suggesting that calling from within the group may provide a 'cheap' advertisement strategy. Additionally, we show that subordinates use information regarding the composition of neighbouring groups to target the greatest number of potential mating partners.

  10. [The Projet PIE: a promising strategy to reach elders with a mental health problem].

    PubMed

    Nour, Kareen; Brown, Brita; Moscovitz, Nona; Hébert, Marijo; Regenstreif, Alan

    2009-01-01

    Approximately fifty percent of older adults with a mental health problem do not receive services. A proactive outreach strategy, Project PIE (Prevention-Intervention-Education) relies upon the assistance of non-traditional referral sources, namely community liaisons, to identify and refer to the CSSS vulnerable or isolated elders with a mental health problem. An evaluation of this project reveals encouraging results. The project appears useful, relevant and efficient to detect elders with a mental health problem and offer the required assistance. This project also appears to be a means to foster social solidarity.

  11. Pharmaceuticals and the Environment (PiE): Evolution and impact of the published literature revealed by bibliometric analysis.

    PubMed

    Daughton, Christian G

    2016-08-15

    The evolution and impact of the published literature surrounding the transdisciplinary, multifaceted topic of pharmaceuticals as contaminants in the environment is examined for the first time in an historical context. The preponderance of literature cited in this examination represents the earlier works. As an historical chronology, the focus is on the emergence of key, specific aspects of the overall topic (often termed PiE) in the published literature and on the most highly cited works. This examination is not a conventional, technical review of the literature; as such, little attention was devoted to the more recent literature. The many dimensions involved with PiE span over 70years of published literature. Some articles began to appear in published works in the 1940s and earlier, while others only began to receive attention in the 1990s and later. Decades of early research on what at the time seemed to be disconnected topics eventually coalesced in the mid-to-late 1990s around a number of interconnected concerns and issues that now comprise PiE. Major objectives are to provide a new perspective to the topic, to facilitate more efficient and effective review of the literature by others, and to recognize the more significant, seminal contributions to the advancement of PiE as a field of research. Some of the most highly cited articles in all of environmental science now involve PiE. As of April 2015, a core group of 385 PiE articles had each received at least 200 citations; one had received 5424 citations. But hundreds of additional articles also played important roles in the evolution and advancement of the field.

  12. Quadriceps and patellar tendon pie-crusting as a treatment for limited flexion in total knee arthroplasty.

    PubMed

    Burge, J Ross; Sanchez, Hugo B; Wagner, Russell A

    2014-04-01

    The pie-crusting method of ligament and tendon lengthening has been used successfully in various tissues but is not reported in the literature as an option for patellar or quadriceps tendons to address flexion limitation. Our case report discusses a patient with longstanding flexion limitation who underwent primary total knee arthroplasty. The report reviews the literature on intraoperative treatments, which primarily pertains to the condition of patella baja, and demonstrates that the pie-crusting technique should be included as a treatment option for a tight extensor mechanism while having some advantages over tibial tubercle osteotomy or Z-plasty.

  13. EC as PIE: five criteria for executing a successful DNP final project.

    PubMed

    Waldrop, Julee; Caruso, Diane; Fuchs, Mary Ann; Hypes, Kathe

    2014-01-01

    The goal of doctor of nursing practice (DNP) programs should be to produce nurses that are uniquely prepared to bridge the gap between the discovery of new knowledge and the scholarship of translation, application, and integration of this new knowledge in practice (American Association of Colleges of Nursing [AACN], 2006). However, there is concern over the variability in DNP programs and expected outcomes. The aim of this article is to describe a 5-point system of evaluation to determine whether a DNP final project meets the outcomes of the AACN Essentials of Doctoral Education in Advanced Nursing Practice (2006) in a comprehensive and rigorous way. In brief, the five criteria that must be met are represented by the acronym EC as PIE (E = Enhances; C = Culmination; P = Partnerships; I = Implements; E = Evaluates). Each criterion must be present and come together to form one complete "pie" representing evidence-based practice that is robust and innovative, culminating in a rigorous doctoral level DNP final project. In addition, we provide detailed examples of how these standards are currently being successfully implemented and discuss additional possibilities.

  14. Pie waste - A component of food waste and a renewable substrate for producing ethanol.

    PubMed

    Magyar, Margaret; da Costa Sousa, Leonardo; Jayanthi, Singaram; Balan, Venkatesh

    2017-02-17

    Sugar-rich food waste is a sustainable feedstock that can be converted into ethanol without an expensive thermochemical pretreatment that is commonly used in first and second generation processes. In this manuscript we have outlined the pie waste conversion to ethanol through a two-step process, namely, enzyme hydrolysis using commercial enzyme products mixtures and microbial fermentation using yeast. Optimized enzyme cocktail was found to be 45% alpha amylase, 45% gamma amylase, and 10% pectinase at 2.5mg enzyme protein/g glucan produced a hydrolysate with high glucose concentration. All three solid loadings (20%, 30%, and 40%) produced sugar-rich hydrolysates and ethanol with little to no enzyme or yeast inhibition. Enzymatic hydrolysis and fermentation process mass balance was carried out using pie waste on a 1000g dry weight basis that produced 329g ethanol at 20% solids loading. This process clearly demonstrate how food waste could be efficiently converted to ethanol that could be used for making biodiesel by reacting with waste cooking oil.

  15. The relationship of family characteristics and bipolar disorder using causal-pie models.

    PubMed

    Chen, Y-C; Kao, C-F; Lu, M-K; Yang, Y-K; Liao, S-C; Jang, F-L; Chen, W J; Lu, R-B; Kuo, P-H

    2014-01-01

    Many family characteristics were reported to increase the risk of bipolar disorder (BPD). The development of BPD may be mediated through different pathways, involving diverse risk factor profiles. We evaluated the associations of family characteristics to build influential causal-pie models to estimate their contributions on the risk of developing BPD at the population level. We recruited 329 clinically diagnosed BPD patients and 202 healthy controls to collect information in parental psychopathology, parent-child relationship, and conflict within family. Other than logistic regression models, we applied causal-pie models to identify pathways involved with different family factors for BPD. The risk of BPD was significantly increased with parental depression, neurosis, anxiety, paternal substance use problems, and poor relationship with parents. Having a depressed mother further predicted early onset of BPD. Additionally, a greater risk for BPD was observed with higher numbers of paternal/maternal psychopathologies. Three significant risk profiles were identified for BPD, including paternal substance use problems (73.0%), maternal depression (17.6%), and through poor relationship with parents and conflict within the family (6.3%). Our findings demonstrate that different aspects of family characteristics elicit negative impacts on bipolar illness, which can be utilized to target specific factors to design and employ efficient intervention programs.

  16. PIE on Safety-Tested Loose Particles from Irradiated Compact 4-4-2

    SciTech Connect

    Hunn, John D.; Gerczak, Tyler J.; Morris, Robert Noel; Baldwin, Charles A.; Montgomery, Fred C.

    2016-04-01

    Post-irradiation examination (PIE) is being performed in support of tristructural isotropic (TRISO) coated particle fuel development and qualification for High Temperature Gas-cooled Reactors (HTGRs). This work is sponsored by the Department of Energy Office of Nuclear Energy (DOE-NE) through the Advanced Reactor Technologies (ART) Office under the Advanced Gas Reactor Fuel Development and Qualification (AGR) Program. The AGR-1 experiment was the first in a series of TRISO fuel irradiation tests initiated in 2006. The AGR-1 TRISO particles and fuel compacts were fabricated at Oak Ridge National Laboratory (ORNL) in 2006 using laboratory-scale equipment and irradiated for 3 years in the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL) to demonstrate and evaluate fuel performance under HTGR irradiation conditions. Post-irradiation examination was performed at INL and ORNL to study how the fuel behaved during irradiation, and to test fuel performance during exposure to elevated temperatures at or above temperatures that could occur during a depressurized conduction cooldown event. This report summarizes safety testing and post-safety testing PIE conducted at ORNL on loose particles extracted from irradiated AGR-1 Compact 4-4-2.

  17. Difficult Dialogues, Privilege and Social Justice: Uses of the Privileged Identity Exploration (PIE) Model in Student Affairs Practice

    ERIC Educational Resources Information Center

    Watt, Sherry K.

    2007-01-01

    This article will introduce the Privileged Identity Exploration (PIE) Model. This model identifies eight (8) defense modes associated with behaviors individuals display when engaged in difficult dialogues about social justice issues. Implications for the model and ways it can be used to assist facilitators as they engage participants in…

  18. A Comparison of Learning Management Systems in a School District: Searching for the Ideal Personalized Integrated Educational System (PIES)

    ERIC Educational Resources Information Center

    Yildirim, Zahide; Reigeluth, Charles M.; Kwon, Seolim; Kageto, Yuichi; Shao, Zihang

    2014-01-01

    This study explored the use of several learning management systems (LMS), their benefits, and their limitations in relation to the desired characteristics of an ideal Personalized Integrated Educational System (PIES) for the information age. A qualitative research design was used. The participants of the study were teachers, administrators, and…

  19. 49 CFR 40.373 - Before starting a PIE proceeding, does the initiating official give the service agent an...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Before starting a PIE proceeding, does the initiating official give the service agent an opportunity to correct problems? 40.373 Section 40.373 Transportation Office of the Secretary of Transportation PROCEDURES FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Public...

  20. 49 CFR 40.369 - What is the discretion of an initiating official in starting a PIE proceeding?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What is the discretion of an initiating official in starting a PIE proceeding? 40.369 Section 40.369 Transportation Office of the Secretary of Transportation PROCEDURES FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.369 What is the discretion of...

  1. [Comparative analysis of Ayrshire and Black Pied cattle breeds by histocompatibility markers].

    PubMed

    Udina, I G; Karamysheva, E E; Sulimova, G E; Pavlenko, S P; Turkova, S O; Orlova, A R; Ernst, L K

    1998-12-01

    Distribution of BoLA-A antigens and BoLA-DRB3 alleles was studied by means of the microlymphocytotoxic test (BoLA-A) and the PCR-RFLP method (BoLA-DRB3) using restriction endonucleases RSAI, HaeIII, and XhoII in Ayrshire (n = 127) and Black Pied (n = 129) cattle breeds. Comparative analysis of profiles for class I antigens revealed significant differences in the frequencies of antigens W2, W6, W10, W31, W44, W15, and W19 (P > 99%). The studied breeds also differ in the spectrum of BoLA-DRB3 alleles and distribution of their frequencies. Heterogeneous allele frequency profile was detected in Ayrshire cattle: five of 18 detected alleles (DRB3.2*7, *8, *10, *24, and *28) accounted for 77%. Allele DRB3.2*7 (37.6%), which is classed with rare alleles in Black Pied cattle is the most common in Ayrshire cattle. The observed heterozygosity level in the combined sample of Black Pied breed (0.836) is higher than in Ayrshire breed (0.070). In both breeds, the heterozygosity level was studied in the groups of healthy and ill with persistent lymphocytosis (caused by bovine leukemia virus) animals and in the group of virus carriers in Ayrshire breed. In ill animals, a decrease in the observed heterozygosity level was detected, as compared to healthy animals and the expected heterozygosity level. The observed heterozygosity level exceeds the expected one in virus carriers. The detected features of the heterozygosity level in the studied groups allow the heterozygosity level for locus BoLA-DRB3 to be considered a nonspecific factor of resistance to leukemia and are heterozygous animals to have higher resistance to bovine leukemia. The presence of a larger proportion of highly productive animals (the annual productivity of more than 7000 kg) in the group of ill Ayrshire cattle animals, as compared to healthy animals to established. To increase resistance to bovine leukemia, the obtained data indicate the importance of the control of heterozygosity level and genetic diversity for

  2. In vivo amelioration of endogenous antitumor autoantibodies via low-dose P4N through the LTA4H/activin A/BAFF pathway

    PubMed Central

    Lin, Yu-Ling; Tsai, Nu-Man; Hsieh, Cheng-Hao; Ho, Shu-Yi; Chang, Jung; Wu, Hsin-Yi; Hsu, Ming-Hua; Chang, Chia-Ching; Liao, Kuang-Wen; Jackson, Tiffany L. B.; Mold, David E.; Huang, Ru Chih C.

    2016-01-01

    Cancer progression is associated with the development of antitumor autoantibodies in patients’ sera. Although passive treatment with antitumor antibodies has exhibited remarkable therapeutic efficacy, inhibitory effects on tumor progression by endogenous antitumor autoantibodies (EAAs) have been limited. In this study, we show that P4N, a derivative of the plant lignan nordihydroguaiaretic acid (NDGA), enhanced the production of EAAs and inhibited tumor growth at low noncytotoxic concentrations via its immunoregulatory activity. Intratumoral injection of P4N improved the quantity and quality of EAAs, and passive transfer of P4N-induced EAAs dramatically suppressed lung metastasis formation and prolonged the survival of mice inoculated with metastatic CT26 tumor cells. P4N-induced EAAs specifically recognized two surface antigens, 78-kDa glucose-regulated protein (GRP78) and F1F0 ATP synthase, on the plasma membrane of cancer cells. Additionally, P4N treatment led to B-cell proliferation, differentiation to plasma cells, and high titers of autoantibody production. By serial induction of autocrine and paracrine signals in monocytes, P4N increased B-cell proliferation and antibody production via the leukotriene A4 hydrolase (LTA4H)/activin A/B-cell activating factor (BAFF) pathway. This mechanism provides a useful platform for studying and seeking a novel immunomodulator that can be applied in targeting therapy by improving the quantity and quality of the EAAs. PMID:27856749

  3. In vivo amelioration of endogenous antitumor autoantibodies via low-dose P4N through the LTA4H/activin A/BAFF pathway.

    PubMed

    Lin, Yu-Ling; Tsai, Nu-Man; Hsieh, Cheng-Hao; Ho, Shu-Yi; Chang, Jung; Wu, Hsin-Yi; Hsu, Ming-Hua; Chang, Chia-Ching; Liao, Kuang-Wen; Jackson, Tiffany L B; Mold, David E; Huang, Ru Chih C

    2016-11-29

    Cancer progression is associated with the development of antitumor autoantibodies in patients' sera. Although passive treatment with antitumor antibodies has exhibited remarkable therapeutic efficacy, inhibitory effects on tumor progression by endogenous antitumor autoantibodies (EAAs) have been limited. In this study, we show that P4N, a derivative of the plant lignan nordihydroguaiaretic acid (NDGA), enhanced the production of EAAs and inhibited tumor growth at low noncytotoxic concentrations via its immunoregulatory activity. Intratumoral injection of P4N improved the quantity and quality of EAAs, and passive transfer of P4N-induced EAAs dramatically suppressed lung metastasis formation and prolonged the survival of mice inoculated with metastatic CT26 tumor cells. P4N-induced EAAs specifically recognized two surface antigens, 78-kDa glucose-regulated protein (GRP78) and F1F0 ATP synthase, on the plasma membrane of cancer cells. Additionally, P4N treatment led to B-cell proliferation, differentiation to plasma cells, and high titers of autoantibody production. By serial induction of autocrine and paracrine signals in monocytes, P4N increased B-cell proliferation and antibody production via the leukotriene A4 hydrolase (LTA4H)/activin A/B-cell activating factor (BAFF) pathway. This mechanism provides a useful platform for studying and seeking a novel immunomodulator that can be applied in targeting therapy by improving the quantity and quality of the EAAs.

  4. Statement-Pie: a strategy to improve the paragraph writing skills of adolescents with learning disabilities.

    PubMed

    Wallace, G W; Bott, D A

    1989-11-01

    This study investigated the effects of teaching a metacognitive text structure strategy upon the paragraph writing skills of eighth-grade students with learning disabilities. The technique, called Statement-Pie (Hanau, 1974), teaches students to understand the relationship of supporting details to a main idea. Four students were taught to use an outline as a paragraph planning guide, which they then used to convert information into written expository paragraphs. All subjects reached instructional outcome criterion on the writing of comparison/contrast and sequence paragraphs. One week after reaching mastery in the special education classroom, students generalized their paragraph writing skills to other teachers and to different classrooms. The results of this investigation indicate that when provided with direct, intensive instruction in a text structure strategy, adolescents with learning disabilities can improve their skills in paragraph writing.

  5. Variable step size and order strategy for delay differential equations in PIE(CIE)s mode

    NASA Astrophysics Data System (ADS)

    Aziz, Nurul Huda Abdul; Majid, Zanariah Abdul

    2014-12-01

    This article deals with the strategy of variable step size and variable order implementation that has been formulated for solving first order of delay differential equations. This strategy is adapted in PIE(CIE)s mode which is generally based on predictor-corrector scheme in multistep block method of order 4 to 9 with s is for convergence test. The purpose here is to enhance the efficiency of the developed predictor-corrector algorithm in the capability to vary automatically not only for the step size, but the order of the method employed as well. All order and coefficients are stored in the code in order to avoid an expensive computational work. The delay argument would be evaluated using Newton divided-difference interpolation at which the points involved would be similar to the current order of the method. Illustrative examples are included to demonstrate the validity and applicability of the presented strategy and comparison is made with the existing results.

  6. Biomechanical validation of medial pie-crusting for soft-tissue balancing in knee arthroplasty.

    PubMed

    Mihalko, William M; Woodard, Erik L; Hebert, Casey T; Crockarell, John R; Williams, John L

    2015-02-01

    Balancing a varus knee is traditionally accomplished by releasing the medial soft-tissue sleeve off the tibia. Recently, "pie-crusting" (PC) medial structures has been described. In a biomechanical cadaver study we compared PC to traditional release (TR) to determine their effects on flexion and extension gaps. PC was done in five specimens along the anterior half of the medial soft-tissue sleeve and five along the posterior half, followed by a traditional release. In 90° flexion, valgus laxity after TR was significantly greater than after PC alone. PC of the anterior or posterior aspect of the medial soft-tissue sleeve can effect changes more in flexion than in extension, respectively. Complete TR did not provide more gap opening than PC in extension, but produced more effect in flexion.

  7. Alternate non-stop migration strategies of pied flycatchers to cross the Sahara desert

    PubMed Central

    Both, Christiaan

    2016-01-01

    Each year more than two billion songbirds cross the Sahara, but how they perform this formidable task is largely unknown. Using geolocation tracks from 27 pied flycatchers, a nocturnally migrating passerine, we show that most birds made diurnal flights in both autumn and spring. These diurnal flights were estimated to be part of non-stop flights of mostly 40–60 h. In spring, birds flew across the Sahara, while autumn migration probably circumpassed part of the desert, through a long oversea flight. Our data contradict claims that passerines cross the Sahara by intermittent flight and daytime resting. The frequent occurrence of long non-stop flights to cross the desert shows migrants' physiological abilities and poses the question why this would not be the general migration strategy to cross the Sahara. PMID:27072404

  8. Variete Technique du Lambeau Sural dans les Brulures Profondes du Pied

    PubMed Central

    Ezzoubi, M.; Ettalbi, S.; Elmounjid, S.; Fassi, J.; Benchamckha, F.J.; Sakhi, M.; Boukind, E.

    2005-01-01

    Summary Les couvertures des pertes de substance de la jambe, du talon et du pied font souvent appel au lambeau sural, qui reste, de part ses dimensions, une indication limitée. Les Auteurs présentent, à travers deux cas cliniques, une variété technique pour la levée du lambeau sural, permettant d'obtenir des palettes cutanées de grande surface avec une bonne sécurité vasculaire. C'est un lambeau fasciocutané remontant jusqu'à un centimètre du creux poplité et incluant, lors de la levée, l'aponévrose, le nerf sural, la petite veine saphène et le nerf sural latéral. PMID:21990988

  9. Optical properties of the hydrated charged silver tetramer and silver hexamer encapsulated inside the sodalite cavity of an LTA-type zeolite.

    PubMed

    Cuong, Ngo Tuan; Nguyen, Hue Minh Thi; Pham-Ho, My Phuong; Nguyen, Minh Tho

    2016-07-21

    The optical spectra in the UV-VIS region of the hydrated doubly charged tetramer Ag4(2+) and hydrated multiply charged hexamer Ag6(p+) silver clusters encapsulated inside the sodalite cavity of an LTA-type zeolite have been systematically predicted using DFT, TD-DFT and CASSCF/CASPT2 methods. The optical behaviour of the model hydrated clusters [Ag6(H2O)8(Si24H24O36)](p+) is very sensitive to their charge. Among the cations [Ag6(H2O)8(Si24H24O36)](p+), only the embedded hydrated quadruply charged silver hexamer [Ag6(H2O)8(Si24H24O36)](4+) shows a strong absorption band at ∼420 nm (blue light) and emits light in red color. The absorption spectrum of the hydrated doubly charged silver tetramer cluster [Ag4(H2O)m(Si24H24O36)](2+), which shifts slightly and steadily with the increasing amount of interacting water molecules to longer wavelengths, has a strong peak in the blue region. The water environment forces the silver tetramer to relocate into one side of the cavity instead of at its center as in the case of the non-hydrated [Ag4(Si24H24O36)](2+) cluster. Water molecules act as ligands significantly splitting the energy levels of excited states of the Ag4(2+) and Ag6(4+) clusters. This causes the absorption spectra of the clusters to broaden and the emission to shift to the green-yellow and red part of the visible region.

  10. Application of large-scale computing infrastructure for diverse environmental research applications using GC3Pie

    NASA Astrophysics Data System (ADS)

    Maffioletti, Sergio; Dawes, Nicholas; Bavay, Mathias; Sarni, Sofiane; Lehning, Michael

    2013-04-01

    , execute location-based subroutines at each grid point and store the results back into the central repository for post-processing. An optional extension of this infrastructure will be to provide a 'ring buffer'-type database infrastructure, such that model results (e.g. test runs made to check parameter dependency or for development) can be visualised and downloaded after completion without submitting them to a permanent storage infrastructure. Data organization Data collected from sensors are archived and classified in distributed sites connected with an open-source software middleware, GSN. Publicly available data are available through common web services and via a cloud storage server (based on Swift). Collocation of the data and processing in the cloud would eventually eliminate data transfer requirements. Execution control logic Execution of the data analysis pipelines (for both the R-based analysis and the Alpine3D simulations) has been implemented using the GC3Pie framework developed by UZH. (https://code.google.com/p/gc3pie/). This allows large-scale, fault-tolerant execution of the pipelines to be described in terms of software appliances. GC3Pie also allows supervision of the execution of large campaigns of appliances as a single simulation. This poster will present the fundamental architectural components of the data analysis pipelines together with initial experimental results.

  11. The strategy for numerical solving of PIES without explicit calculation of singular integrals in 2D potential problems

    NASA Astrophysics Data System (ADS)

    Szerszeń, Krzysztof; Zieniuk, Eugeniusz

    2016-06-01

    The paper presents a strategy for numerical solving of parametric integral equation system (PIES) for 2D potential problems without explicit calculation of singular integrals. The values of these integrals will be expressed indirectly in terms of easy to compute non-singular integrals. The effectiveness of the proposed strategy is investigated with the example of potential problem modeled by the Laplace equation. The strategy simplifies the structure of the program with good the accuracy of the obtained solutions.

  12. Syndrome de larva migrans cutanée sur pied malformé (à propos d'un cas)

    PubMed Central

    Benbella, Imane; Khalki, Hanane; Lahmadi, Khalid; Kouara, Sara; Abbadi, Abderrahim; Er-rami, Mohammed

    2016-01-01

    Le syndrome de larva migrans cutanée est une dermite sous cutanée causée par des larves d'ankylostomes d'animaux en impasse parasitaire chez l'homme. L'infestation transcutanée est favorisée par le contact avec le sol contaminé par les larves du parasite. Nous rapportons le cas d'un nourrisson de 15 mois, originaire de Guinée-Bissau, atteint d'un syndrome de larva migrans cutanée sur un pied malformé. Cette malformation sous forme d'une syndactylie associée à une tuméfaction du pied, était à l'origine d'un retard d'acquisition de la station debout. De même, on a rapporté une notion de pieds nus, vue la difficulté de chausser le pied malformé du patient. Tous ces facteurs auraient contribués à favoriser l'infestation du malade par les larves du nématode. PMID:27217876

  13. Slow improvements of metal exposure, health- and breeding conditions of pied flycatchers (Ficedula hypoleuca) after decreased industrial heavy metal emissions.

    PubMed

    Berglund, A M M; Nyholm, N E I

    2011-09-15

    The environment around metal industries, such as smelters, is often highly contaminated due to continuous deposition of metals. We studied nest box breeding populations of pied flycatchers (Ficedula hypoleuca) in a well-studied pollution gradient from a sulfide ore smelter in Northern Sweden, after reduced aerial metal emissions (by 93-99%) from the smelter. The deposition of arsenic, cadmium, copper and zinc (based on moss samples) reflected the reduced emissions fairly well. However, nestling pied flycatchers had similar concentrations of these elements and mercury in tissues (bone, liver and blood) and feces in the 2000s, as in the 1980s, when the emissions were substantially higher. The exposure to high metal concentrations in the close vicinity of the smelter resulted in inhibited ALAD activities, depressed hemoglobin and hematocrit levels and increased mortality of nestlings. Our results indicate that in the highly contaminated environment around the smelter, nestlings reflected the slowly cycling soil pool, rather than the atmospheric deposition, and the concentration in soils plays an important role for the response of pied flycatchers to reduced atmospheric deposition.

  14. Miniature Gas Chromatograph (GC): Penning Ionization Electron Spectroscopy (PIES) Instrument for the Trace Analyses of Extraterrestrial Environments

    NASA Technical Reports Server (NTRS)

    Kojiro, Daniel R.; Sheverev, Valery A.; Holland, Paul M.; Takeuchi, Norishige

    2006-01-01

    In situ exploration of the solar system to identify its early chemistry as preserved in icy bodies and to look for compelling evidence of astrobiology will require new technology for chemical analysis. Chemical measurements in space flight environments highlight the need for a high level of positive identification of chemical compounds, since re-measurement by alternative techniques for confirmation will not be feasible. It also may not be possible to anticipate all chemical species that are observed, and important species may be present only at trace levels where they can be masked by complex chemical backgrounds. Up to now, the only techniques providing independent sample identification of GC separated components across a wide range of chemical species have been Mass Spectrometry (MS) and Ion Mobility Spectrometry (IMS). We describe here the development of a versatile and robust miniature GC detector based on Penning Ionization Electron Spectroscopy (PIES), for use with miniature GC systems being developed for planetary missions. PIES identifies the sample molecule through spectra related to its ionization potential. The combination of miniature GC technology with the primary identification capabilities of PIES provides an analytical approach ideal for planetary analyses.

  15. Monitoring lipid anchor organization in cell membranes by PIE-FCCS.

    PubMed

    Triffo, Sara B; Huang, Hector H; Smith, Adam W; Chou, Eldon T; Groves, Jay T

    2012-07-04

    This study examines the dynamic co-localization of lipid-anchored fluorescent proteins in living cells using pulsed-interleaved excitation fluorescence cross-correlation spectroscopy (PIE-FCCS) and fluorescence lifetime analysis. Specifically, we look at the pairwise co-localization of anchors from lymphocyte cell kinase (LCK: myristoyl, palmitoyl, palmitoyl), RhoA (geranylgeranyl), and K-Ras (farnesyl) proteins in different cell types. In Jurkat cells, a density-dependent increase in cross-correlation among RhoA anchors is observed, while LCK anchors exhibit a more moderate increase and broader distribution. No correlation was detected among K-Ras anchors or between any of the different anchor types studied. Fluorescence lifetime data reveal no significant Förster resonance energy transfer in any of the data. In COS 7 cells, minimal correlation was detected among LCK or RhoA anchors. Taken together, these observations suggest that some lipid anchors take part in anchor-specific co-clustering with other existing clusters of native proteins and lipids in the membrane. Importantly, these observations do not support a simple interpretation of lipid anchor-mediated organization driven by partitioning based on binary lipid phase separation.

  16. The why of practice: utilizing PIE to analyze social work practice in Australian hospitals.

    PubMed

    Nilsson, David; Joubert, Lynette; Holland, Lucy; Posenelli, Sonia

    2013-01-01

    This research used a collaborative approach to gain a comprehensive, quantitative understanding of the breadth and depth of the social work role in health care. Data was collected from individual interviews with all employed hospital social workers (N = 120) across five Melbourne, Australia health networks about their most recently completed case. This data was coded using a revised version of the Karls and Wandrei (1994) Person-in-Environment (PIE) tool to retrospectively analyze the reasons for social work involvement over the course of the case. The findings demonstrate that the hospital social work role is multidimensional across a number of domains but centers predominantly on assisting clients and their significant others with issues of altered social roles and functioning; particularly in relation to role responsibility, dependency, and managing associated role-change losses. The findings of this study will assist hospital social workers, managers, and academics to better describe and effectively undertake this complex work. These findings will also assist in the development of professional training and education to up-skill social workers who operate within this complex setting.

  17. Pie-like electrode design for high-energy density lithium-sulfur batteries

    NASA Astrophysics Data System (ADS)

    Li, Zhen; Zhang, Jin Tao; Chen, Yu Ming; Li, Ju; Lou, Xiong Wen (David)

    2015-11-01

    Owing to the overwhelming advantage in energy density, lithium-sulfur (Li-S) battery is a promising next-generation electrochemical energy storage system. Despite many efforts in pursuing long cycle life, relatively little emphasis has been placed on increasing the areal energy density. Herein, we have designed and developed a `pie' structured electrode, which provides an excellent balance between gravimetric and areal energy densities. Combining lotus root-like multichannel carbon nanofibers `filling' and amino-functionalized graphene `crust', the free-standing paper electrode (S mass loading: 3.6 mg cm-2) delivers high specific capacity of 1,314 mAh g-1 (4.7 mAh cm-2) at 0.1 C (0.6 mA cm-2) accompanied with good cycling stability. Moreover, the areal capacity can be further boosted to more than 8 mAh cm-2 by stacking three layers of paper electrodes with S mass loading of 10.8 mg cm-2.

  18. Pie-like electrode design for high-energy density lithium-sulfur batteries.

    PubMed

    Li, Zhen; Zhang, Jin Tao; Chen, Yu Ming; Li, Ju; Lou, Xiong Wen David

    2015-11-26

    Owing to the overwhelming advantage in energy density, lithium-sulfur (Li-S) battery is a promising next-generation electrochemical energy storage system. Despite many efforts in pursuing long cycle life, relatively little emphasis has been placed on increasing the areal energy density. Herein, we have designed and developed a 'pie' structured electrode, which provides an excellent balance between gravimetric and areal energy densities. Combining lotus root-like multichannel carbon nanofibers 'filling' and amino-functionalized graphene 'crust', the free-standing paper electrode (S mass loading: 3.6 mg cm(-2)) delivers high specific capacity of 1,314 mAh g(-1) (4.7 mAh cm(-2)) at 0.1 C (0.6 mA cm(-2)) accompanied with good cycling stability. Moreover, the areal capacity can be further boosted to more than 8 mAh cm(-2) by stacking three layers of paper electrodes with S mass loading of 10.8 mg cm(-2).

  19. Temporal regularity increases with repertoire complexity in the Australian pied butcherbird's song

    PubMed Central

    Taylor, Hollis; Scharff, Constance; Rothenberg, David; Parra, Lucas C.; Tchernichovski, Ofer

    2016-01-01

    Music maintains a characteristic balance between repetition and novelty. Here, we report a similar balance in singing performances of free-living Australian pied butcherbirds. Their songs include many phrase types. The more phrase types in a bird's repertoire, the more diverse the singing performance can be. However, without sufficient temporal organization, avian listeners may find diverse singing performances difficult to perceive and memorize. We tested for a correlation between the complexity of song repertoire and the temporal regularity of singing performance. We found that different phrase types often share motifs (notes or stereotyped groups of notes). These shared motifs reappeared in strikingly regular temporal intervals across different phrase types, over hundreds of phrases produced without interruption by each bird. We developed a statistical estimate to quantify the degree to which phrase transition structure is optimized for maximizing the regularity of shared motifs. We found that transition probabilities between phrase types tend to maximize regularity in the repetition of shared motifs, but only in birds of high repertoire complexity. Conversely, in birds of low repertoire complexity, shared motifs were produced with less regularity. The strong correlation between repertoire complexity and motif regularity suggests that birds possess a mechanism that regulates the temporal placement of shared motifs in a manner that takes repertoire complexity into account. We discuss alternative musical, mechanistic and ecological explanations to this effect. PMID:27703699

  20. [EEG in altricial pied flycatcher nestlings during the functional sates related with natural behavior cycle].

    PubMed

    Korneeva, E V; Aleksandrov, L I; Khramov, A E; Sitnikova, E Iu; Raevskiĭ, V V

    2014-01-01

    Electrical brain activity accompanying various forms of behavior was studied in 11-day-old pied flycatcher nestlings. Wavelet analysis of EEG, recorded from symmetrical areas of caudomedial nidopallium (higher avian auditory center) during rest, passive and active wakefulness and movements showed that the major rhythmical EEG component was confined to low-frequency range in all four states. The significant difference from other states was observed only during movements: spectral power in the range of 1-3 Hz decreased while that in the range of 5-20 Hz--increased. The range of 3-5 Hz revealed, in all functional states, the interhemispheric asymmetry of spectral power that could be due to asymmetrical embryonic development of avian visual projections. Active wakefulness and movements were characterized by high positive correlations between spectral power in right and left hemispheres. During rest this correlation was negative. The correlation values during passive wakefulness and rest were rather low that could indicate disintegration of neural connections.

  1. Pie-like electrode design for high-energy density lithium–sulfur batteries

    PubMed Central

    Li, Zhen; Zhang, Jin Tao; Chen, Yu Ming; Li, Ju; Lou, Xiong Wen (David)

    2015-01-01

    Owing to the overwhelming advantage in energy density, lithium–sulfur (Li–S) battery is a promising next-generation electrochemical energy storage system. Despite many efforts in pursuing long cycle life, relatively little emphasis has been placed on increasing the areal energy density. Herein, we have designed and developed a ‘pie' structured electrode, which provides an excellent balance between gravimetric and areal energy densities. Combining lotus root-like multichannel carbon nanofibers ‘filling' and amino-functionalized graphene ‘crust', the free-standing paper electrode (S mass loading: 3.6 mg cm−2) delivers high specific capacity of 1,314 mAh g−1 (4.7 mAh cm−2) at 0.1 C (0.6 mA cm−2) accompanied with good cycling stability. Moreover, the areal capacity can be further boosted to more than 8 mAh cm−2 by stacking three layers of paper electrodes with S mass loading of 10.8 mg cm−2. PMID:26608228

  2. Placental immune editing switch (PIES): learning about immunomodulatory pathways from a unique case report.

    PubMed

    Bronchud, Miguel H; Tresserra, Francesc; Xu, Wenjie; Warren, Sarah; Cusido, Maite; Zantop, Bernat; Zenclussen, Ana Claudia; Cesano, Alessandra

    2016-12-13

    The hypothesis of this work is that, in order to escape the natural immune surveillance mechanisms, cancer cells and the surrounding microenvironment might express ectopically genes that are physiologically present in the placenta to mediate fetal immune-tolerance. These natural "placental immune-editing switch" mechanisms (PIES) may represent the result of millions of years of mammalian evolution developed to allow materno-fetal tolerance. Here, we introduce genes of the immune regulatory pathways that are either similarly over- or under-expressed in tumor vs normal tissue. Our analysis was carried out in primary breast cancer with metastatic homolateral axillary lymph nodes as well as placenta tissue (both uterine decidual tissue and term placenta tissue) from a pregnant woman. Gene expression profiling of paired non-self and self tissues (i.e. placenta/uterus; breast cancer/normal breast tissue; metastatic lymphnode/normal lymphnode tissue) was performed using the PanCancer Immune gene panel, a 770 Nanostring gene expression panel. Our findings reveal overlapping in specific immune gene expression in placenta and cancer tissue, suggesting that these genes might play an important role in maintaining immune tolerance both physiologically (in the placenta) and pathologically (in the cancer setting).

  3. In-Situ Detection of Micrometeoroids and Orbital Debris: The Pie Experiment On MIR.

    NASA Astrophysics Data System (ADS)

    Mandeville, J. C.; Maag, C. R.; Durin, C.

    During the last few years, investigation of impact features found on material retrieved after exposure to space for a long period of time, in low earth orbits, has provided us with a great deal of data on the particulate environment, either natural or man-made. The PIE detection device presented here has been deployed outside the Kvant-2 module attached to the Russian MIR station, between June 1996 and April 1997. Part of the experiment uses a detection technique similar to the one used in previous experiments flown on LDEF and MIR. Passive sensors are composed primarly of stacked thin metal foils (gold and aluminium). According to the size of the particles, they are either decelerated or fragmented upon high velocity impact. The size of holes or impact craters give information on the size or shape of the impacting particles. Samples have been retrieved for laboratory analysis. Comparison with data from LDEF, EuReCa, HST and previous experiments on MIR provides insight in the long term evolution of small particle population and in the debris environment of a permanently manned station. Some of the samples show evidence of secondary impact cratering: an attempt is made to locate the origin of the primary impact site. Some results about the possible origin of the impactors are provided by the chemical identification of particle remnants inside the craters

  4. Placental immune editing switch (PIES): learning about immunomodulatory pathways from a unique case report

    PubMed Central

    Bronchud, Miguel H.; Tresserra, Francesc; Xu, Wenjie; Warren, Sarah; Cusido, Maite; Zantop, Bernat; Zenclussen, Ana Claudia; Cesano, Alessandra

    2016-01-01

    The hypothesis of this work is that, in order to escape the natural immune surveillance mechanisms, cancer cells and the surrounding microenvironment might express ectopically genes that are physiologically present in the placenta to mediate fetal immune-tolerance. These natural “placental immune-editing switch” mechanisms (PIES) may represent the result of millions of years of mammalian evolution developed to allow materno-fetal tolerance. Here, we introduce genes of the immune regulatory pathways that are either similarly over- or under-expressed in tumor vs normal tissue. Our analysis was carried out in primary breast cancer with metastatic homolateral axillary lymph nodes as well as placenta tissue (both uterine decidual tissue and term placenta tissue) from a pregnant woman. Gene expression profiling of paired non-self and self tissues (i.e. placenta/uterus; breast cancer/normal breast tissue; metastatic lymphnode/normal lymphnode tissue) was performed using the PanCancer Immune gene panel, a 770 Nanostring gene expression panel. Our findings reveal overlapping in specific immune gene expression in placenta and cancer tissue, suggesting that these genes might play an important role in maintaining immune tolerance both physiologically (in the placenta) and pathologically (in the cancer setting). PMID:27852037

  5. MOX Average Power Test 30 GWd/MT PIE: Quick Look

    SciTech Connect

    MORRIS, RN

    2001-02-14

    This report summarizes the early results of the post irradiation examination of the 30 GWd/MT MOX Average Power Test Capsules (numbers 3 and 10). The purpose of this preliminary examination is to document and monitor the progress of the MOX Average Power Test Irradiation. The capsules and their fuel pins were found to be in excellent condition. Measurement of the fission gas release fraction (about 1.50 to 2.26%), preliminary fuel stack gamma scan measurements, and preliminary fuel pin diameter measurements indicate that the fuel is behaving as expected.

  6. Preparation, crystal structure, and thermal stability of the cadmium sulfide nanoclusters Cd6S44+ and Cd2Na2S4+in the sodalite cavities of zeolite A (LTA).

    PubMed

    Kim, Seok Han; Heo, Nam Ho; Kim, Ghyung Hwa; Hong, Suk Bong; Seff, Karl

    2006-12-28

    The crystal structure and thermal stability of two cadmium sulfide nanoclusters prepared in zeolite A (LTA) have been studied by XPS, TGA, and single-crystal and powder XRD. The crystal structures of Cd2.4Na3.2(Cd6S4)0.4(Cd2Na2S)0.6(H2O)> or =5.8[Si12Al12O48]-LTA (a = 12.2919(7) A, crystal 1 (hydrated)) and /Cd4Na2(Cd2O)(Na2O)/[Si12Al12O48]-LTA (a = 12.2617(4) A, crystal 2 (dehydrated)) were determined by single-crystal methods in the cubic space group Pm3m at 294(1) K. Crystal 1 was prepared by ion exchange of Na12-LTA in an aqueous stream 0.05 M in Cd2+, followed by washing in a stream of water, followed by reaction in an aqueous stream 0.05 M in Na2S. Crystal 2 was made by dehydrating crystal 1 at 623 K and 1 x 10(-6) Torr for 3 days. In crystal 1, Cd6S4(4+) nanoclusters were found in and extending out of about 40% of the sodalite cavities. Central to each Cd6S4(4+) cluster is a Cd4S4 unit (interpenetrating Cd2+ and S2- tetrahedra with near Td symmetry, Cd-S = 2.997(24) A, Cd-S-Cd = 113.8(12) degrees, and S-Cd-S = 58.1(24) degrees). Each of the two remaining Cd2+ ions bonds radially through a 6-ring of the zeolite framework to a sulfide ion of this Cd4S4 unit (Cd-S = 2.90(8) A). In each of the remaining 60% of the sodalite cavities of crystal 1, a planar Cd2Na2S4+ cluster was found (Cd-S/Na-S = 2.35(5)/2.56(14) A and Cd-S-Cd/Na-S-Na = 122(5)/92(7) degrees). Cd6S4(4+) and Cd2Na2S4+ are stable within the zeolite up to about 700 K in air. Upon vacuum dehydration at 623 K, all sulfur was lost (crystal 2). Instead as anions, only two oxide ions remain per sodalite unit. One bridges between two Cd2+ ions (Cd2O2+, Cd-O = 2.28(3) A) and the other between two Na+ ions (Na2O, Na-O = 2.21(10) A).

  7. Meaningful call combinations and compositional processing in the southern pied babbler.

    PubMed

    Engesser, Sabrina; Ridley, Amanda R; Townsend, Simon W

    2016-05-24

    Language's expressive power is largely attributable to its compositionality: meaningful words are combined into larger/higher-order structures with derived meaning. Despite its importance, little is known regarding the evolutionary origins and emergence of this syntactic ability. Although previous research has shown a rudimentary capability to combine meaningful calls in primates, because of a scarcity of comparative data, it is unclear to what extent analog forms might also exist outside of primates. Here, we address this ambiguity and provide evidence for rudimentary compositionality in the discrete vocal system of a social passerine, the pied babbler (Turdoides bicolor). Natural observations and predator presentations revealed that babblers produce acoustically distinct alert calls in response to close, low-urgency threats and recruitment calls when recruiting group members during locomotion. On encountering terrestrial predators, both vocalizations are combined into a "mobbing sequence," potentially to recruit group members in a dangerous situation. To investigate whether babblers process the sequence in a compositional way, we conducted systematic experiments, playing back the individual calls in isolation as well as naturally occurring and artificial sequences. Babblers reacted most strongly to mobbing sequence playbacks, showing a greater attentiveness and a quicker approach to the loudspeaker, compared with individual calls or control sequences. We conclude that the sequence constitutes a compositional structure, communicating information on both the context and the requested action. Our work supports previous research suggesting combinatoriality as a viable mechanism to increase communicative output and indicates that the ability to combine and process meaningful vocal structures, a basic syntax, may be more widespread than previously thought.

  8. Meaningful call combinations and compositional processing in the southern pied babbler

    PubMed Central

    Engesser, Sabrina; Ridley, Amanda R.; Townsend, Simon W.

    2016-01-01

    Language’s expressive power is largely attributable to its compositionality: meaningful words are combined into larger/higher-order structures with derived meaning. Despite its importance, little is known regarding the evolutionary origins and emergence of this syntactic ability. Although previous research has shown a rudimentary capability to combine meaningful calls in primates, because of a scarcity of comparative data, it is unclear to what extent analog forms might also exist outside of primates. Here, we address this ambiguity and provide evidence for rudimentary compositionality in the discrete vocal system of a social passerine, the pied babbler (Turdoides bicolor). Natural observations and predator presentations revealed that babblers produce acoustically distinct alert calls in response to close, low-urgency threats and recruitment calls when recruiting group members during locomotion. On encountering terrestrial predators, both vocalizations are combined into a “mobbing sequence,” potentially to recruit group members in a dangerous situation. To investigate whether babblers process the sequence in a compositional way, we conducted systematic experiments, playing back the individual calls in isolation as well as naturally occurring and artificial sequences. Babblers reacted most strongly to mobbing sequence playbacks, showing a greater attentiveness and a quicker approach to the loudspeaker, compared with individual calls or control sequences. We conclude that the sequence constitutes a compositional structure, communicating information on both the context and the requested action. Our work supports previous research suggesting combinatoriality as a viable mechanism to increase communicative output and indicates that the ability to combine and process meaningful vocal structures, a basic syntax, may be more widespread than previously thought. PMID:27155011

  9. A bipartite U1 site represses U1A expression by synergizing with PIE to inhibit nuclear polyadenylation.

    PubMed

    Guan, Fei; Caratozzolo, Rose M; Goraczniak, Rafal; Ho, Eric S; Gunderson, Samuel I

    2007-12-01

    U1A protein negatively autoregulates itself by polyadenylation inhibition of its own pre-mRNA by binding as two molecules to a 3'UTR-located Polyadenylation Inhibitory Element (PIE). The (U1A)2-PIE complex specifically blocks U1A mRNA biosynthesis by inhibiting polyA tail addition, leading to lower mRNA levels. U1 snRNP bound to a 5'ss-like sequence, which we call a U1 site, in the 3'UTRs of certain papillomaviruses leads to inhibition of viral late gene expression via a similar mechanism. Although such U1 sites can also be artificially used to potently silence reporter and endogenous genes, no naturally occurring U1 sites have been found in eukaryotic genes. Here we identify a conserved U1 site in the human U1A gene that is, unexpectedly, within a bipartite element where the other part represses the U1 site via a base-pairing mechanism. The bipartite element inhibits U1A expression via a synergistic action with the nearby PIE. Unexpectedly, synergy is not based on stabilizing binding of the inhibitory factors to the 3'UTR, but rather is a property of the larger ternary complex. Inhibition targets the biosynthetic step of polyA tail addition rather than altering mRNA stability. This is the first example of a functional U1 site in a cellular gene and of a single gene containing two dissimilar elements that inhibit nuclear polyadenylation. Parallels with other examples where U1 snRNP inhibits expression are discussed. We expect that other cellular genes will harbor functional U1 sites.

  10. Captive breeding and reintroduction of the oriental pied hornbill (Anthracoceros albirostris) in Khao Kheow Open Zoo, Thailand.

    PubMed

    Chaiyarat, Rattanawat; Kongprom, Urarikha; Manathamkamon, Darika; Wanpradab, Sunan; Sangarang, Satean

    2012-01-01

    This article discusses two related issues of the captive breeding and reintroduction of the Oriental pied hornbill (Anthracoceros albirostris) in order to increase its population in the natural habitats. Oriental pied hornbills were bred in Khao Kheow Open Zoo. Three pairs were separated and kept in breeding cages. Females occupied artificial nests between February and April 2005-2007. Eggs were laid and incubated between February and March each year from 2005 to 2007. Nestlings hatched in late March and left the nest in late April 2005-2007. Each breeding pair was fed with approximately 400 g of food each day. All three pairs reproduced resulting in mature offspring of seven in 2005, six in 2006, and five in 2007. Four of sixteen 3-year-old birds were randomly selected and equipped with a GPS receiver on their backs. Activities of the birds attached and unattached with GPS were not significantly different. The first two birds (one female, one male with GPS) were reintroduced on August 5, 2006, and another nine birds (four birds with GPS) were reintroduced on December 26, 2006. The average home range of these reintroduced birds was 0.13 km(2) . Their foods consisted of wild plants and animals in the home range. The first reintroduced pair was able to breed naturally by laying and hatching eggs in an artificial nest. Two juveniles left the nest in April 2008. These results indicate that both captive breeding and reintroduction are potentially important ways to increase the population of the Oriental pied hornbill in natural habitats.

  11. Vortex wake, downwash distribution, aerodynamic performance and wingbeat kinematics in slow-flying pied flycatchers

    PubMed Central

    Muijres, Florian T.; Bowlin, Melissa S.; Johansson, L. Christoffer; Hedenström, Anders

    2012-01-01

    Many small passerines regularly fly slowly when catching prey, flying in cluttered environments or landing on a perch or nest. While flying slowly, passerines generate most of the flight forces during the downstroke, and have a ‘feathered upstroke’ during which they make their wing inactive by retracting it close to the body and by spreading the primary wing feathers. How this flight mode relates aerodynamically to the cruising flight and so-called ‘normal hovering’ as used in hummingbirds is not yet known. Here, we present time-resolved fluid dynamics data in combination with wingbeat kinematics data for three pied flycatchers flying across a range of speeds from near hovering to their calculated minimum power speed. Flycatchers are adapted to low speed flight, which they habitually use when catching insects on the wing. From the wake dynamics data, we constructed average wingbeat wakes and determined the time-resolved flight forces, the time-resolved downwash distributions and the resulting lift-to-drag ratios, span efficiencies and flap efficiencies. During the downstroke, slow-flying flycatchers generate a single-vortex loop wake, which is much more similar to that generated by birds at cruising flight speeds than it is to the double loop vortex wake in hovering hummingbirds. This wake structure results in a relatively high downwash behind the body, which can be explained by the relatively active tail in flycatchers. As a result of this, slow-flying flycatchers have a span efficiency which is similar to that of the birds in cruising flight and which can be assumed to be higher than in hovering hummingbirds. During the upstroke, the wings of slowly flying flycatchers generated no significant forces, but the body–tail configuration added 23 per cent to weight support. This is strikingly similar to the 25 per cent weight support generated by the wing upstroke in hovering hummingbirds. Thus, for slow-flying passerines, the upstroke cannot be regarded as

  12. Vortex wake, downwash distribution, aerodynamic performance and wingbeat kinematics in slow-flying pied flycatchers.

    PubMed

    Muijres, Florian T; Bowlin, Melissa S; Johansson, L Christoffer; Hedenström, Anders

    2012-02-07

    Many small passerines regularly fly slowly when catching prey, flying in cluttered environments or landing on a perch or nest. While flying slowly, passerines generate most of the flight forces during the downstroke, and have a 'feathered upstroke' during which they make their wing inactive by retracting it close to the body and by spreading the primary wing feathers. How this flight mode relates aerodynamically to the cruising flight and so-called 'normal hovering' as used in hummingbirds is not yet known. Here, we present time-resolved fluid dynamics data in combination with wingbeat kinematics data for three pied flycatchers flying across a range of speeds from near hovering to their calculated minimum power speed. Flycatchers are adapted to low speed flight, which they habitually use when catching insects on the wing. From the wake dynamics data, we constructed average wingbeat wakes and determined the time-resolved flight forces, the time-resolved downwash distributions and the resulting lift-to-drag ratios, span efficiencies and flap efficiencies. During the downstroke, slow-flying flycatchers generate a single-vortex loop wake, which is much more similar to that generated by birds at cruising flight speeds than it is to the double loop vortex wake in hovering hummingbirds. This wake structure results in a relatively high downwash behind the body, which can be explained by the relatively active tail in flycatchers. As a result of this, slow-flying flycatchers have a span efficiency which is similar to that of the birds in cruising flight and which can be assumed to be higher than in hovering hummingbirds. During the upstroke, the wings of slowly flying flycatchers generated no significant forces, but the body-tail configuration added 23 per cent to weight support. This is strikingly similar to the 25 per cent weight support generated by the wing upstroke in hovering hummingbirds. Thus, for slow-flying passerines, the upstroke cannot be regarded as inactive

  13. Effects of inbreeding on fighting ability measured in Aosta Chestnut and Aosta Black Pied cattle.

    PubMed

    Sartori, C; Mantovani, R

    2012-09-01

    Aosta Black Pied (ABP) and Aosta Chestnut (AC) are dual-purpose cattle indigenous to the western Alps and famous for their fighting ability in traditional Italian Batailles de Reines. The present study aimed to investigate the influence of inbreeding on breeding values for fighting ability achieved in participants. Inbreeding (F) and average relatedness (AR) were obtained from the entire pedigree information available (19,554 and 87,967 records for ABP and AC, respectively). Data (n = 23,998) relating to 8,259 cows competing in years 2001-2009 were analyzed to obtain heritability (h(2)) estimates and breeding values for the trait. A placement score was chosen as a phenotype for fighting ability and both a classical quantitative model (NORM) and its implementation, used to identify its indirect genetic effects (COMP), were analyzed using the expectation maximization-REML (EM-REML) method. The F and AR trends in animals born between 1990 and 2009 were generally low and were greater for ABP (+0.06%/yr) than for AC (+0.03%/yr) populations, which also presented a greater mean F (about 2.8% ± 1.7% vs. 0.8% ± 1.5% for ABP and AC, respectively) and mean AR among individuals (about 1.0% ± 0.8% vs. 0.4% ± 0.3% for ABP and AC, respectively). Heritability estimates from 0.083 ± 0.036 to 0.120 ± 0.037 were obtained using the NORM model, accounting for or not accounting for F, respectively. Similar results were obtained also for the COMP model, with h(2) estimates of 0.12 ± 0.037, whether or not F was taken into consideration. Linear regression analyses carried out on the 33 major lineages to which most of participants belonged (n = 6,087) revealed an overall negative trend of EBV compared with the increase of either F (b = -21.3, P < 0.01) or AR (b = -50.1, P < 0.01). However, a great variability in the relationship between EBV and F or AR was found by analyzing data within lineages. Despite the variability, an unfavorable effect of inbreeding was detected in the

  14. Candidate genes for colour and vision exhibit signals of selection across the pied flycatcher (Ficedula hypoleuca) breeding range.

    PubMed

    Lehtonen, P K; Laaksonen, T; Artemyev, A V; Belskii, E; Berg, P R; Both, C; Buggiotti, L; Bureš, S; Burgess, M D; Bushuev, A V; Krams, I; Moreno, J; Mägi, M; Nord, A; Potti, J; Ravussin, P-A; Sirkiä, P M; Sætre, G-P; Winkel, W; Primmer, C R

    2012-04-01

    The role of natural selection in shaping adaptive trait differentiation in natural populations has long been recognized. Determining its molecular basis, however, remains a challenge. Here, we search for signals of selection in candidate genes for colour and its perception in a passerine bird. Pied flycatcher plumage varies geographically in both its structural and pigment-based properties. Both characteristics appear to be shaped by selection. A single-locus outlier test revealed 2 of 14 loci to show significantly elevated signals of divergence. The first of these, the follistatin gene, is expressed in the developing feather bud and is found in pathways with genes that determine the structure of feathers and may thus be important in generating variation in structural colouration. The second is a gene potentially underlying the ability to detect this variation: SWS1 opsin. These two loci were most differentiated in two Spanish pied flycatcher populations, which are also among the populations that have the highest UV reflectance. The follistatin and SWS1 opsin genes thus provide strong candidates for future investigations on the molecular basis of adaptively significant traits and their co-evolution.

  15. Differentiation in neutral genes and a candidate gene in the pied flycatcher: using biological archives to track global climate change.

    PubMed

    Kuhn, Kerstin; Schwenk, Klaus; Both, Christiaan; Canal, David; Johansson, Ulf S; van der Mije, Steven; Töpfer, Till; Päckert, Martin

    2013-11-01

    Global climate change is one of the major driving forces for adaptive shifts in migration and breeding phenology and possibly impacts demographic changes if a species fails to adapt sufficiently. In Western Europe, pied flycatchers (Ficedula hypoleuca) have insufficiently adapted their breeding phenology to the ongoing advance of food peaks within their breeding area and consequently suffered local population declines. We address the question whether this population decline led to a loss of genetic variation, using two neutral marker sets (mitochondrial control region and microsatellites), and one potentially selectively non-neutral marker (avian Clock gene). We report temporal changes in genetic diversity in extant populations and biological archives over more than a century, using samples from sites differing in the extent of climate change. Comparing genetic differentiation over this period revealed that only the recent Dutch population, which underwent population declines, showed slightly lower genetic variation than the historic Dutch population. As that loss of variation was only moderate and not observed in all markers, current gene flow across Western and Central European populations might have compensated local loss of variation over the last decades. A comparison of genetic differentiation in neutral loci versus the Clock gene locus provided evidence for stabilizing selection. Furthermore, in all genetic markers, we found a greater genetic differentiation in space than in time. This pattern suggests that local adaptation or historic processes might have a stronger effect on the population structure and genetic variation in the pied flycatcher than recent global climate changes.

  16. A novel putative lipoprotein receptor (CasLpR) in the hemocytes of the blue crab, Callinectes sapidus: cloning and up-regulated expression after the injection of LPS and LTA.

    PubMed

    Tsutsui, Naoaki; Chung, J Sook

    2012-03-01

    The full-length cDNA encoding a putative lipoprotein receptor (CasLpR) was isolated from the hemocytes of Callinectes sapidus using 5' and 3' RACEs. The open reading frame for CasLpR contains a precursor of putative CasLpR consisting of 1710 amino acid residues including 22 amino acid residues of the signal peptide (22 amino acids). Mature CasLpR (1688 amino acids with 5.6% of phosphorylation sites) has multiple, putative functional domains: five low-density lipoprotein receptor domains in the N-terminus, and a G-protein-coupled receptor proteolysis site domain and a 7 transmembrane receptor (secretin family) domain in the C-terminus. To date, there are no proteins with a similar domain structure in the GenBank. The expression pattern of CasLpR was exclusive in hemocytes among all tested tissues obtained from a juvenile female at intermolt stage: brain, eyestalk ganglia, pericardial organs, and thoracic ganglia complex (nervous system); hepatopancreas (digestive system); heart, artery and hemocytes (circulatory system); gill and antennal gland (excretory system), hypodermis; and Y-organ (endocrine organ). There was no CasLpR expression in the ovary of an adult female. A putative function of CasLpR was examined after challenges of lipopolysaccharides (LPS) and lipoteichoic acid (LTA) in vivo using qRT-PCR assays. Animals at 24 h after injection of LPS or LTA up-regulated the expression of CasLpR in hemocytes by ∼3.5 and 1.4 folds, respectively, compared to the controls that received saline injection. LPS challenge also caused the greatest increment (∼55 folds) of heat shock protein 90 (Hsp90) expression in these samples. These data indicate that putative CasLpR and CasHsp90 may be involved in the defense system or the stress response of C. sapidus.

  17. 49 CFR 40.371 - On what information does an initiating official rely in deciding whether to start a PIE proceeding?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false On what information does an initiating official rely in deciding whether to start a PIE proceeding? 40.371 Section 40.371 Transportation Office of the Secretary of Transportation PROCEDURES FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Public Interest Exclusions § 40.371 On...

  18. Fifteen-year population attributable fractions and causal pies of risk factors for newly developed hepatocellular carcinomas in 11,801 men in Taiwan.

    PubMed

    Liao, Shu-Fen; Yang, Hwai-I; Lee, Mei-Hsuan; Chen, Chien-Jen; Lee, Wen-Chung

    2012-01-01

    Development of hepatocellular carcinoma (HCC) is a multi-factorial process. Chronic infections with hepatitis B virus (HBV) and hepatitis C virus (HCV) are important risk factors of HCC. Host factors, such as alcohol drinking, may also play a role. This study aims to provide a synthesis view on the development of HCC by examining multiple risk factors jointly and collectively. Causal-pie modeling technique was applied to analyze a cohort of 11,801 male residents (followed up for 15 years) in Taiwan, during which a total of 298 incident HCC cases were ascertained. The rate ratios adjusted by age were further modeled by an additive Poisson regression. Population attributable fractions (PAFs) and causal-pie weights (CPWs) were calculated. A PAF indicates the magnitude of case-load reduction under a particular intervention scenario, whereas a CPW for a particular class of causal pies represents the proportion of HCC cases attributable to that class. Using PAF we observed a chance to reduce around 60% HCC risk moving from no HBV-related intervention to the total elimination of the virus. An additional ∼15% (or ∼5%) reduction can be expected, if the HBV-related intervention is coupled with an HCV-related intervention (or an anti-drinking campaign). Eight classes of causal pies were found to be significant, including four dose-response classes of HBV (total CPW=52.7%), one independent-effect class of HCV (CPW=14.4%), one HBV-alcohol interaction class (CPW=4.2%), one HBV-HCV interaction class (CPW=1.7%), and one all-unknown class (CPW=27.0%). Causal-pie modeling for HCC helps clarify the relative importance of each viral and host factor, as well as their interactions.

  19. Overflow transports in Denmark Strait and the Faroe Bank Channel derived from combined moored ADCP and PIES measurements during 2011-2014

    NASA Astrophysics Data System (ADS)

    Moritz, Martin; Jochumsen, Kerstin; Quadfasel, Detlef

    2015-04-01

    The Denmark Strait (DS) and Faroe Bank Channel (FBC) are the major pathways of dense water leaving the Arctic Mediterranean. The water formed in the Nordic Seas crosses the sills of this passages and descends into the deep North Atlantic Ocean where it becomes part of the North Atlantic Deep Water. Estimates of strength and variability of these overflows are useful to observe temporal changes and understand mechanisms that may affect the Atlantic Meridional Overturning Circulation. The velocities in the overflows have been measured with Acoustic Doppler Current Profilers (ADCPs) for almost two decades. For transport estimates the thickness of the overflow plume is typically derived from the depth of maximum velocity shear. During 2011 and 2014 Pressure Inverted Echo Sounders (PIES) were added to the mooring sites. The thickness of the plume of overflow water that is usually characterized to be denser than σΦ=27.8 kgm-3 can be estimated from hydrographic profiles that were obtained from travel time measurements of the PIES. The volume transports in DS, calculated from ADCPs only and in combination with the plume thickness derived from PIES measurements, are compared. The mean difference between both is about 3% of the total transport of 3 Sv. Nevertheless, daily estimates can differ within the same magnitude, whereas the difference of monthly estimates reduces to about 0.3 Sv. The heat transport of the overflow relative to 0° C calculated from combined PIES and ADCP measurements across the DS varies within the order of 10 TW. Estimates of transports from hydraulic control theory were derived from PIES data upstream of the sills in DS and FBC and compared to transport observations at the sills. Additionally, the variability within the vertical structure of the water column in DS and FBC are analysed.

  20. First results of the 74-MHz Very Large Array-Pie Town link. Hercules A at low frequencies

    NASA Astrophysics Data System (ADS)

    Gizani, Nectaria A. B.; Cohen, A.; Kassim, N. E.

    2005-04-01

    We present the results of the first successful observations of the Pie Town link with the Very Large Array at 74 MHz on Hercules A. The improvement in resolution from 25 to 10 arcsec resolves the helical- and ring-like features seen at higher frequencies. We also present new high dynamic range images of this powerful radio galaxy at 325 MHz. Our low-frequency observations confirm the multiple outburst interpretation of the spectral index differences at high frequencies. A comparison between our radio and ROSAT X-ray data does not reveal any association between the X-ray emission from the cluster and the radio lobes. There are no extra regions of radio emission at 74 MHz.

  1. A new classification of the Pied Woodpeckers assemblage (Dendropicini, Picidae) based on a comprehensive multi-locus phylogeny.

    PubMed

    Fuchs, Jérôme; Pons, Jean-Marc

    2015-07-01

    The pied woodpecker assemblage historically included the widespread genera Picoides and Dendrocopos. The assignment of species to either of these two genera has for long puzzled systematists due to their overall plumage similarity. Recent molecular studies not only suggested that both of these genera are not monophyletic, but also that four other genera, the African Dendropicos the South American Veniliornis and two Asian monospecific genera (Hypopicus and Sapheopipo) are nested within the Dendrocopos-Picoides clade. Yet, our current understanding of the phylogeny and taxonomy of this group is still very partial because several distinctive Old World species that have been assigned to different genera throughout their taxonomic history have not been sampled yet. Here, using DNA sequence data gathered from four loci, we reconstructed a species level phylogeny of the Indo-Malayan and Palearctic Pied Woodpeckers to understand the phylogenetic relationships and biogeographic history of the Eurasian species with respect to African and New World lineages. Our phylogenetic analyses revealed nine strongly supported clades within the Dendropicini. Noticeably, two species that had disputed affinities at the genus level clustered in clades with species from the same biogeographical region: the Brown-backed Woodpecker (D. obsoletus) is nested in Dendropicos and the Arabian Woodpecker (D. dorae) is related to two Eurasian species, the Brown-fronted (D. auriceps) and Middle-spotted woodpeckers (D. medius). The nine clades have a strong biogeographic component and very few dispersal event among bioregions occurred. For example, the African species formed a clade, suggesting that only one dispersal event is needed to explain the presence of Dendropicini in Africa. Based on our phylogenetic results, we propose a new classification of the Dendropicini that recognizes nine genera.

  2. Demographic Divergence History of Pied Flycatcher and Collared Flycatcher Inferred from Whole-Genome Re-sequencing Data

    PubMed Central

    Nadachowska-Brzyska, Krystyna; Burri, Reto; Olason, Pall I.; Kawakami, Takeshi; Smeds, Linnéa; Ellegren, Hans

    2013-01-01

    Profound knowledge of demographic history is a prerequisite for the understanding and inference of processes involved in the evolution of population differentiation and speciation. Together with new coalescent-based methods, the recent availability of genome-wide data enables investigation of differentiation and divergence processes at unprecedented depth. We combined two powerful approaches, full Approximate Bayesian Computation analysis (ABC) and pairwise sequentially Markovian coalescent modeling (PSMC), to reconstruct the demographic history of the split between two avian speciation model species, the pied flycatcher and collared flycatcher. Using whole-genome re-sequencing data from 20 individuals, we investigated 15 demographic models including different levels and patterns of gene flow, and changes in effective population size over time. ABC provided high support for recent (mode 0.3 my, range <0.7 my) species divergence, declines in effective population size of both species since their initial divergence, and unidirectional recent gene flow from pied flycatcher into collared flycatcher. The estimated divergence time and population size changes, supported by PSMC results, suggest that the ancestral species persisted through one of the glacial periods of middle Pleistocene and then split into two large populations that first increased in size before going through severe bottlenecks and expanding into their current ranges. Secondary contact appears to have been established after the last glacial maximum. The severity of the bottlenecks at the last glacial maximum is indicated by the discrepancy between current effective population sizes (20,000–80,000) and census sizes (5–50 million birds) of the two species. The recent divergence time challenges the supposition that avian speciation is a relatively slow process with extended times for intrinsic postzygotic reproductive barriers to evolve. Our study emphasizes the importance of using genome-wide data to

  3. [Nourseothricin (streptothricin) inactivated by plasmid pIE 636-encoded acetyltransferase: detection of N-acetyl-beta-lysine in the inactivated product].

    PubMed

    Seltmann, G

    1985-12-01

    Nourseothricin (streptothricin) can be inactivated by an acetyl transferase synthesized by E. coli strains containing plasmid pIE 636. Nourseothricin inactivated in the presence of 14C-acetyl-coenzyme A was purified and submitted to partial acidic hydrolysis. By electrophoresis of the hydrolysate a 14C-containing substance moving only slowly towards the cathode could be isolated. This substance after complete hydrolysis yields only unlabelled beta-lysine.

  4. A New Dual-Frequency Liquid Crystal Lens with Ring-and-Pie Electrodes and a Driving Scheme to Prevent Disclination Lines and Improve Recovery Time

    PubMed Central

    Kao, Yung-Yuan; Chao, Paul C.-P.

    2011-01-01

    A new liquid crystal lens design is proposed to improve the recovery time with a ring-and-pie electrode pattern through a suitable driving scheme and using dual-frequency liquid crystals (DFLC) MLC-2048. Compared with the conventional single hole-type liquid crystal lens, this new structure of the DFLC lens is composed of only two ITO glasses, one of which is designed with the ring-and-pie pattern. For this device, one can control the orientation of liquid crystal directors via a three-stage switching procedure on the particularly-designed ring-and-pie electrode pattern. This aims to eliminate the disclination lines, and using different drive frequencies to reduce the recovery time to be less than 5 seconds. The proposed DFLC lens is shown effective in reducing recovery time, and then serves well as a potential device in places of the conventional lenses with fixed focus lengths and the conventional LC lens with a single circular-hole electrode pattern. PMID:22163906

  5. A new dual-frequency liquid crystal lens with ring-and-pie electrodes and a driving scheme to prevent disclination lines and improve recovery time.

    PubMed

    Kao, Yung-Yuan; Chao, Paul C-P

    2011-01-01

    A new liquid crystal lens design is proposed to improve the recovery time with a ring-and-pie electrode pattern through a suitable driving scheme and using dual-frequency liquid crystals (DFLC) MLC-2048. Compared with the conventional single hole-type liquid crystal lens, this new structure of the DFLC lens is composed of only two ITO glasses, one of which is designed with the ring-and-pie pattern. For this device, one can control the orientation of liquid crystal directors via a three-stage switching procedure on the particularly-designed ring-and-pie electrode pattern. This aims to eliminate the disclination lines, and using different drive frequencies to reduce the recovery time to be less than 5 seconds. The proposed DFLC lens is shown effective in reducing recovery time, and then serves well as a potential device in places of the conventional lenses with fixed focus lengths and the conventional LC lens with a single circular-hole electrode pattern.

  6. Uranium hydrogeochemical survey of well waters from an area around Pie Town, Catron County, West-Central New Mexico, including concentrations of twenty-three additional elements

    SciTech Connect

    Morgan, T.L.; George, W.E.; Hensley, W.K.; Thomas, G.J.; Langhorst, A.L.

    1980-10-01

    As part of the Hydrogeochemical and Stream Sediment Reconnaissance (HSSR) of the National Uranium Resource Evaluation (NURE) sponsored by the US Department of Energy (DOE), the Los Alamos Scientific Laboratory (LASL) conducted a detailed hydrogeochemical survey of well waters in a 4250-km/sup 2/ area near Pie Town in west-central New Mexico. A total of 300 well samples was collected and analyzed for uranium and 23 other elements. The results of these analyses and carbonate and bicarbonate ion concentrations are presented in the Appendixes of this report. Uranium concentrations range from below the detection limit of 0.02 parts per billion (ppB) to 293.18 ppB and average 8.71 ppB. Samples containing high levels of uranium were collected from the Largo Creek valley west of Quemado, from a small area about 6 km east of Quemado, from a small area surrounding Pie Town, and from scattered locations in the area surrounding Adams Diggings north of Pie Town. Most of the samples containing high uranium concentrations were collected from wells associated with the volcanic sedimentary facies of the Datil formation. This formation is a likely source of mobile uranium that may be precipitating in the underlying Baca formation, a known uranium host unit. Bicarbonate ion concentration, while proportional to uranium concentration in some cases, is not a strong controlling factor in the uranium concentrations in samples from this area.

  7. Active basement uplift of Sierra Pie de Palo (Northwestern Argentina): Rates and inception from10Be cosmogenic nuclide concentrations

    NASA Astrophysics Data System (ADS)

    Siame, Lionel L.; Sébrier, Michel; Bellier, Olivier; Bourlès, Didier; Costa, Carlos; Ahumada, Emilio A.; Gardini, Carlos E.; Cisneros, Hector

    2015-06-01

    Quaternary tectonic and denudation rates are investigated for an actively growing basement anticline: the Sierra Pie de Palo range, which belongs to the Andean foreland of Northwestern Argentina (28°S-33°S). In this study, a detailed morphometric analysis of the topography is combined with in situ-produced cosmogenic10Be concentrations measured in (1) surface boulders abandoned on alluvial terraces affected by fault activity (along the north bounding fault) and growth of the basement fold (along the southeastern border), (2) bedrock outcrops corresponding to an exhumed and folded, regional erosion surface, and (3) fluvial sediments sampled at the outlets of several watersheds. Along the eastern and northern borders of the range, incision and uplift rates have been estimated at approximately 0.5 and 1 mm/yr when integrated on Holocene and Pleistocene time scales, in close agreement with both long-term (structural and basin evolution data) and short-term (GPS-derived velocity field) analyses. Cosmogenic-derived denudation and uplift rates combined with geomorphic characteristics of watersheds and river channels allows estimating the onset of the uplift at 4-6 Ma, followed by a more recent period of topographic rejuvenation at roughly 1-2 Ma, probably synchronous with steepening of the eastern and northern flanks of the anticline.

  8. Effects of pollution on land snail abundance, size and diversity as resources for pied flycatcher, Ficedula hypoleuca.

    PubMed

    Eeva, Tapio; Rainio, Kalle; Suominen, Otso

    2010-09-01

    Passerine birds need extra calcium during their breeding for developing egg shells and proper growth of nestling skeleton. Land snails are an important calcium source for many passerines and human-induced changes in snail populations may pose a severe problem for breeding birds. We studied from the bird's viewpoint how air pollution affects the shell mass, abundance and diversity of land snail communities along a pollution gradient of a copper smelter. We sampled remnant snail shells from the nests of an insectivorous passerine, the pied flycatcher, Ficedula hypoleuca, to find out how the availability of land snails varies along the pollution gradient. The total snail shell mass increased towards the pollution source but declined abruptly in the vicinity of the smelter. This spatial variation in shell mass was evident also within a single snail species and could not be wholly explained by spatially varying snail numbers or species composition. Instead, the total shell mass was related to their shell size, individuals being largest at the moderately polluted areas. Smaller shell size suggests inferior growth of snails in the most heavily polluted area. Our study shows that pollution affects the diversity, abundance (available shell mass) and individual quality of land snails, posing reproductive problems for birds that rely on snails as calcium sources during breeding. There are probably both direct pollution-related (heavy metal and calcium levels) and indirect (habitat change) effects behind the observed changes in snail populations.

  9. Foveolar Müller Cells of the Pied Flycatcher: Morphology and Distribution of Intermediate Filaments Regarding Cell Transparency.

    PubMed

    Zueva, Lidia; Golubeva, Tatiana; Korneeva, Elena; Makarov, Vladimir; Khmelinskii, Igor; Inyushin, Mikhail

    2016-04-01

    Specialized intermediate filaments (IFs) have critical importance for the clearness and uncommon transparency of vertebrate lens fiber cells, although the physical mechanisms involved are poorly understood. Recently, an unusual low-scattering light transport was also described in retinal Müller cells. Exploring the function of IFs in Müller cells, we have studied the morphology and distribution pattern of IFs and other cytoskeletal filaments inside the Müller cell main processes in the foveolar part of the avian (pied flycatcher) retina. We found that some IFs surrounded by globular nanoparticles (that we suggest are crystallines) are present in almost every part of the Müller cells that span the retina, including the microvilli. Unlike IFs implicated in the mechanical architecture of the cell, these IFs are not connected to any specific cellular membranes. Instead, they are organized into bundles, passing inside the cell from the endfeet to the photoreceptor, following the geometry of the processes, and repeatedly circumventing numerous obstacles. We believe that the presently reported data effectively confirm that the model of nanooptical channels built of the IFs may provide a viable explanation of Müller cell transparency.

  10. La place de la double arthrodèse dans la prise en charge du pied bot varus équin invétéré

    PubMed Central

    Atarraf, Karima; Arroud, Mounir; Chater, Lamiae; Afifi, My Abderrahmane

    2014-01-01

    La prise en charge du pied bot varus équin invétéré ( PBVEI) pose d’énormes problèmes thérapeutiques. La double arthrodèse sous-talienne et médio-tarsienne longtemps considérée comme la solution de sécurité pour ces déformations est encore couramment utilisée. Nous rapportons une série de 13 enfants opérés pour un pied bot varus équin invétérés (16 pieds) par Arthrodèse sous-talienne et médio tarsienne réalisée au service d'orthopédie pédiatrique du CHU Hassan II; de Fès au Maroc sur une période de 4 ans; étalée de janvier 2009 à décembre 2012. L’âge moyen de nos patients était de 12,6 ans avec prédominance féminine. L'origine congénitale était retrouvée chez 10 patients. L'atteinte était gauche chez 8 patients avec une localisation bilatérale chez 3 patients. La radiographie standard du pied de face et de profil a révélée une divergence talo-calcanéenne qui variait entre 5 et 20°, l'angle talus-1er métatarsien entre 20 et 40° (avec une moyenne de 28°) et l'angle calcanéus-5ème métatarsien entre 15° et 45° (avec une moyenne de 30°). Tous les patients ont bénéficiés d'une arthrodèse sous-talienne et médio tarsienne. Les résultats étaient satisfaisants dans 98% des cas. Le pied était plantigrade dans 9 cas, le varus de l'arrière pied persistait dans 4 pieds alors que l’équin et le varus de l'avant pied étaient notés chez 2 cas. La double arthrodèse est l'intervention idéale pour stabiliser et corriger les déformations rencontrées dans le PBVE invétéré, elle assure totalement le verrouillage du couple de torsion. Elle permet outre une correction des diverses déformations et une ré-axation de l'arrière-pied dans les 3 plans de l'espace. PMID:25829977

  11. SplicePie: a novel analytical approach for the detection of alternative, non-sequential and recursive splicing.

    PubMed

    Pulyakhina, Irina; Gazzoli, Isabella; 't Hoen, Peter A C; Verwey, Nisha; den Dunnen, Johan T; den Dunnen, Johan; Aartsma-Rus, Annemieke; Laros, Jeroen F J

    2015-07-13

    Alternative splicing is a powerful mechanism present in eukaryotic cells to obtain a wide range of transcripts and protein isoforms from a relatively small number of genes. The mechanisms regulating (alternative) splicing and the paradigm of consecutive splicing have recently been challenged, especially for genes with a large number of introns. RNA-Seq, a powerful technology using deep sequencing in order to determine transcript structure and expression levels, is usually performed on mature mRNA, therefore not allowing detailed analysis of splicing progression. Sequencing pre-mRNA at different stages of splicing potentially provides insight into mRNA maturation. Although the number of tools that analyze total and cytoplasmic RNA in order to elucidate the transcriptome composition is rapidly growing, there are no tools specifically designed for the analysis of nuclear RNA (which contains mixtures of pre- and mature mRNA). We developed dedicated algorithms to investigate the splicing process. In this paper, we present a new classification of RNA-Seq reads based on three major stages of splicing: pre-, intermediate- and post-splicing. Applying this novel classification we demonstrate the possibility to analyze the order of splicing. Furthermore, we uncover the potential to investigate the multi-step nature of splicing, assessing various types of recursive splicing events. We provide the data that gives biological insight into the order of splicing, show that non-sequential splicing of certain introns is reproducible and coinciding in multiple cell lines. We validated our observations with independent experimental technologies and showed the reliability of our method. The pipeline, named SplicePie, is freely available at: https://github.com/pulyakhina/splicing_analysis_pipeline. The example data can be found at: https://barmsijs.lumc.nl/HG/irina/example_data.tar.gz.

  12. A Preliminary Study of Seismicity at Ceboruco, Volcano, Nayarit, Mexico

    NASA Astrophysics Data System (ADS)

    Sanchez, J. J.; Nunez-Cornu, F. J.; Suarez-Plascencia, C.; Trejo-Gomez, E.

    2007-12-01

    Ceboruco Volcano is located northwestern of Tepic-Zacoalco graben (Jalisco, Mexico). Its volcanic activity can be divided in four eruptive cycles differentiated by their volcano explosivity index (VEI) and chemical variations as well. As a result of andesitic effusive activity, during the first cycle the "paleo-Ceboruco" edifice was constructed. The end of this cycle is defined by a plinian eruption (VEI is estimated between 3 and 4) which occurred some 1020 years ago and formed the external caldera. During the second cycle an andesitic dome extruded in the interior of the caldera. The dome, called Dos Equis, collapsed and formed the internal caldera. The third cycle is represented by andesitic lava flows which partially cover the northern and south-southwestern part of the edifice. The last cycle is represented by historic andesitic lava flows located in the southwestern flank of the volcano. In February 2003 as part of an agreement with Nayarit Civil Defense a seismic station was installed in the SW flank of the volcano. The station is equipped with a Marslite (lennartz) digitizer with a 3DLe 1Hz. seismic sensor. Detection system is based on a STA/LTA recording algorithm. More than 2000 small earthquakes have been attributed to various local sources, and some of this earthquakes are possibly located beneath Ceboruco volcano. A preliminary classification separates high frequency and low frequency seismic events. The sources of high frequency earthquakes appear to be distributed as evidenced from waveforms variety and changing S-P arrivals separations. The low frequency seismic events also show varying signatures and some of them exhibit extended coda, including some monochromatic character.

  13. The Canonical Immediate Early 3 Gene Product pIE611 of Mouse Cytomegalovirus Is Dispensable for Viral Replication but Mediates Transcriptional and Posttranscriptional Regulation of Viral Gene Products

    PubMed Central

    Rattay, Stephanie; Trilling, Mirko; Megger, Dominik A.; Sitek, Barbara; Meyer, Helmut E.; Hengel, Hartmut

    2015-01-01

    ABSTRACT Transcription of mouse cytomegalovirus (MCMV) immediate early ie1 and ie3 is controlled by the major immediate early promoter/enhancer (MIEP) and requires differential splicing. Based on complete loss of genome replication of an MCMV mutant carrying a deletion of the ie3-specific exon 5, the multifunctional IE3 protein (611 amino acids; pIE611) is considered essential for viral replication. Our analysis of ie3 transcription resulted in the identification of novel ie3 isoforms derived from alternatively spliced ie3 transcripts. Construction of an IE3-hemagglutinin (IE3-HA) virus by insertion of an in-frame HA epitope sequence allowed detection of the IE3 isoforms in infected cells, verifying that the newly identified transcripts code for proteins. This prompted the construction of an MCMV mutant lacking ie611 but retaining the coding capacity for the newly identified isoforms ie453 and ie310. Using Δie611 MCMV, we demonstrated the dispensability of the canonical ie3 gene product pIE611 for viral replication. To determine the role of pIE611 for viral gene expression during MCMV infection in an unbiased global approach, we used label-free quantitative mass spectrometry to delineate pIE611-dependent changes of the MCMV proteome. Interestingly, further analysis revealed transcriptional as well as posttranscriptional regulation of MCMV gene products by pIE611. IMPORTANCE Cytomegaloviruses are pathogenic betaherpesviruses persisting in a lifelong latency from which reactivation can occur under conditions of immunosuppression, immunoimmaturity, or inflammation. The switch from latency to reactivation requires expression of immediate early genes. Therefore, understanding of immediate early gene regulation might add insights into viral pathogenesis. The mouse cytomegalovirus (MCMV) immediate early 3 protein (611 amino acids; pIE611) is considered essential for viral replication. The identification of novel protein isoforms derived from alternatively spliced ie3

  14. [Genetic mechanisms of resistance and susceptibility to leukemia in Ayrshire and black pied cattle breeds determined by allelic distribution of gene Bola-DRB3].

    PubMed

    Udina, I G; Karamysheva, E E; Turkova, S O; Orlova, A R; Sulimova, G E

    2003-03-01

    In the herds of Ayrshire and Black Pied cattle breeds of Russian selection, comparative analysis of allelic distribution of BoLA-DRB3 was performed in animal groups with different status of persistent lymphocytosis (PL) caused by the bovine leukemia virus (BLV). Alleles were typed by PCR-RFLP. Different spectra of BoLA-DRB3 alleles mediating susceptibility and resistance to leukemia were detected in the studied breeds. The role of amino acid motives in beta 1 domain of BoLA-DRB3 antigens was confirmed: ER (in positions 70-71), in resistance to leukemia and VDTY and VDTV (75-78), in susceptibility to leukemia. The nucleotide sequence of allele BoLA-DRB3.2*7 with deletion of codon 65, which resulted in the changed conformation of the corresponding antigen molecule, was associated with resistance to PL. Cows of Black Pied and Ayrshire breeds with genotypes coding VDTY/VDTV (RR = 11.67, P = 0.014) and VDTY/VDTY (RR = 4.71, P = 0.022), respectively, were shown to be susceptible to PL. The role of heterozygosity level was demonstrated (estimated by BoLA-DRB3 alleles and by amino acid motives in positions 75-78 of the antigen) as an unspecific factor of resistance to PL. The lowest heterozygosity level by amino acid motives (75-78) was revealed in PL animals, for which sample inbreeding coefficients were detected: F = 0.324 and F = 0.084 in Ayrshire and Black Pied breeds, respectively.

  15. Profil bactériologique du pied diabétique et son impact sur le choix des antibiotiques

    PubMed Central

    Zemmouri, Adil; Tarchouli, Mohamed; Benbouha, Abdellatif; Lamkinsi, Tarik; Bensghir, Mustapha; Elouennass, Mostafa; Haimeur, Cherqui

    2015-01-01

    Introduction Analyse du profil bactériologique des pieds diabétiques pris en charge à l'hôpital militaire de Rabat et son influence sur l'antibiothérapie de première intention. Méthodes Etude prospective non randomisée étalée sur 18 mois, ayant concerné 105 patients. Après recueil des données et en attente des résultats bactériologiques nos patients ont été divisés en deux groupes: un groupe a été mis sous Amoxicilline + Acide clavulanique + Gentamycine (59 patients) et un groupe sous Ertapénème±Gentamycine (46 patients). Résultats L’étude a regroupé 85 hommes et 20 femmes (sexe ratio = 4.26). L’âge moyen est de 64.4 ans. La gangrène a été observée chez 79% des malades; elle était humide-donc surinfectée en principe- dans 43% des cas. Par ailleurs, 67% des malades ont un chiffre de globules blancs 12000 définissant une infection sévère. L'ostéolyse a été mise en évidence chez 27% de nos patients. Parmi les différentes techniques de prélèvements: 81% ont été profonds dont 21% de biopsie osseuse per opératoire et 14% de prélèvements combinés. 42% de ces prélèvements sont poly microbiens et 21% sont stériles. Les résultats bactériologiques viennent confirmer la prédominance des bactéries aérobies à Gram positif. Le taux de remplacement de l'Ertapénème est de 22% contre un taux de 50% pour l'Amoxiclav. Conclusion L'antibiothérapie ne doit être instaurée qu'en cas d'infection du pied diabétique diagnostiquée sur les critères cliniques établis par les consensus internationaux récents. Le respect des mesures de lutte contre la diffusion de la résistance bactérienne s'avère primordiale. PMID:27386024

  16. Sharing Smaller Pies.

    ERIC Educational Resources Information Center

    Bender, Tom

    This paper details the unfavorable predicament of the United States as a consequence of using much of its own non-renewable material and energy resources. As a consequence, the United States will soon be subject to the political and economic conditions imposed upon it by other nations. The United States must begin to implement adjustments to the…

  17. Sweetie Pie Thornless Blackberry

    Technology Transfer Automated Retrieval System (TEKTRAN)

    ‘Sweetie Pie’ is a new thornless blackberry (Rubus L. subg. Watson) cultivar developed and released by the USDA-ARS Thad Cochran Southern Horticultural Laboratory. ‘Sweetie Pie’ is a vigorous, semi-erect blackberry that produces moderate yields of sweet high quality fruit having excellent flavor, ...

  18. Aerodynamics and Hovering Control of LTA Vehicles

    DTIC Science & Technology

    1977-05-01

    Cylinders (From Reference 7). 28 ~~0 0 - iI- ~43 0 C*4 JoJ o Di 29rtf IrI ALLEN ( NACA REPT 1048) f ( k a ~~ 01 WHER IS MAX.NEGATIVEdx2 FUR2...size, the propulsive power will decrease as che propeller remote inlet velocity V, decreases. Hence, a wake-immersed propeller can produce the same...M.: "The Aerodynamic Forces on Airship Hulls", NACA Report 184, 1924. 2. Milne-Thompson: THEORETICAL HYDRODYNAMICS, MacMillan, 1955. 3. Koebn, N. E

  19. Basic relationships for LTA technical analysis

    NASA Technical Reports Server (NTRS)

    Ausrotas, R. A.

    1975-01-01

    An introduction to airship performance is presented. Static lift equations are shown which, when combined with power requirements for conventional airships, allow parametric studies of range, payload, speed and airship size. It is shown that very large airships are required to attain reasonable speeds at transoceanic ranges.

  20. Preliminary Drill Sites

    DOE Data Explorer

    Lane, Michael

    2013-06-28

    Preliminary locations for intermediate depth temperature gradient holes and/or resource confirmation wells based on compilation of geological, geophysical and geochemical data prior to carrying out the DOE-funded reflection seismic survey.

  1. [Visual input affects the expression of the early genes c-Fos and ZENK in auditory telencephalic centers of pied flycatcher nestlings during the acoustically-guided freezing].

    PubMed

    Korneeva, E V; Tiunova, A A; Aleksandrov, L I; Golubeva, T B; Anokhin, K V

    2014-01-01

    The present study analyzed expression of transcriptional factors c-Fos and ZENK in 9-day-old pied flycatcher nestlings' (Ficedula hypoleuca) telencephalic auditory centers (field L, caudomedial nidopallium and caudomedial mesopallium) involved in the acoustically-guided defense behavior. Species-typical alarm call was presented to the young in three groups: 1--intact group (sighted control), 2--nestlings visually deprived just before the experiment for a short time (unsighted control) 3--nestlings visually deprived right after hatching (experimental deprivation). Induction of c-Fos as well as ZENK in nestlings from the experimental deprivation group was decreased in both hemispheres as compared with intact group. In the group of unsighted control, only the decrease of c-Fos induction was observed exclusively in the right hemisphere. These findings suggest that limitation of visual input changes the population of neurons involved into the acoustically-guided behavior, the effect being dependant from the duration of deprivation.

  2. Newcastle disease in a zoo affecting demoiselle cranes (Anthropoides virgo), greater flamingos (Phoenicopterus ruber) and a pied imperial pigeon (Ducula bicolor).

    PubMed

    Kaleta, E F; Marschall, H J

    1981-07-01

    Newcastle disease virus could be isolated from demoiselle cranes (Anthropoides virgo), greater flamingos (Phoenicopterus ruber) and a pied imperial pigeon (Ducula bicolor) in chicken embryo fibroblast (CEF) cultures. All of these birds died without prominent symptoms and had no typical pathological lesions. Identification and characterisation studies of the viruses were performed in CEF cultures and embryos. Serological cross reactions could be detected between NDV strain B1 and the new isolates by haemagglutination inhibition and plaque reduction tests. Electron microscopic examination revealed particles with paramyxovirus morphology. Inoculation of susceptible cockerels resulted in severe clinical symptoms and mortality. The distribution of lesions in the digestive tract indicates that the isolated viruses are of the velogenic viscerotropic type.

  3. Preliminary Cruise Report - Iguana Expedition

    DTIC Science & Technology

    A preliminary cruise report of Expedition Iguana , 31 March 1972-11 May 1972, gives some preliminary results, list of equipment and, personnel, stations and data gathered, and track and topographic plots. (Author)

  4. Preliminary AirMSPI Datasets

    Atmospheric Science Data Center

    2016-12-06

    ... Preliminary AirMSPI Datasets   The data files available through this web page and ftp links are preliminary ... geometric corrections. Caution should be used for science analysis. At a later date, more qualified versions will be made public.   ...

  5. On Preliminary Breakdown

    NASA Astrophysics Data System (ADS)

    Beasley, W. H.; Petersen, D.

    2013-12-01

    The preliminary breakdown phase of a negative cloud-to-ground lightning flash was observed in detail. Observations were made with a Photron SA1.1 high-speed video camera operating at 9,000 frames per second, fast optical sensors, a flat-plate electric field antenna covering the SLF to MF band, and VHF and UHF radio receivers with bandwidths of 20 MHz. Bright stepwise extensions of a negative leader were observed at an altitude of 8 km during the first few milliseconds of the flash, and were coincident with bipolar electric field pulses called 'characteristic pulses'. The 2-D step lengths of the preliminary processes were in excess of 100 meters, with some 2-D step lengths in excess of 200 meters. Smaller and shorter unipolar electric field pulses were superposed onto the bipolar electric field pulses, and were coincident with VHF and UHF radio pulses. After a few milliseconds, the emerging negative stepped leader system showed a marked decrease in luminosity, step length, and propagation velocity. Details of these events will be discussed, including the possibility that the preliminary breakdown phase consists not of a single developing lightning leader system, but of multiple smaller lightning leader systems that eventually join together into a single system.

  6. Synchrotron radiation as a tool for in situ investigation of extraterrestrial grains in low-density collectors: application to the analyses of the PIE polymid foams targets

    NASA Astrophysics Data System (ADS)

    Borg, J.; Quirico, E.; Simionovici, A.; Raynal, P.-I.; Chevallier, P.; Langevin, Y.

    2002-08-01

    The Particle Impact Experiment (PIE) was flown for 11 months outside the MIR station in 1996-97. The grains, both of extraterrestrial and terrestrial origins, captured in the low-density foam collectors, were investigated for using Synchrotron X-ray microfluorescence (SXμF) techniques, developed at LURE (Orsay, France) and ESRF (Grenoble, France). The positions of grains a few microns large are known at better than 10 μm. Chemical identification is arduous; only Z>20 elements are identified and, for the heavy elements, only a rough estimate of their abundances inside the grains can be given. We use the Fe/Ni ratio as the criterion allowing to distinguish between terrestrial orbital debris (OD) and extraterrestrial grains. In the 60 cm2 of foam analyzed by this technique, we identified two or three probable extraterrestrial grains and confirmed the existence of an OD cloud, rich in Fe-Ni alloys, crossed by the MIR station. SXμF is a powerful, non-destructive, technique of in situ identification of absorbing grains trapped in a material otherwise transparent to X-rays. It is the only analytical procedure for foams, opaque to visible light. For aerogels, exposed in many space missions and used as grain collectors in the STARDUST mission, the grains positions can be known after an optical scanning; SXμF appears as the last step for the high resolution in situ identification (size, shape, chemical composition) of the grain before its eventual extraction by microtunneling techniques.

  7. Environmental Survey preliminary report

    SciTech Connect

    Not Available

    1988-04-01

    This report presents the preliminary findings from the first phase of the Environmental Survey of the United States Department of Energy (DOE) Sandia National Laboratories conducted August 17 through September 4, 1987. The objective of the Survey is to identify environmental problems and areas of environmental risk associated with Sandia National Laboratories-Albuquerque (SNLA). The Survey covers all environmental media and all areas of environmental regulation. It is being performed in accordance with the DOE Environmental Survey Manual. This phase of the Survey involves the review of existing site environmental data, observations of the operations carried on at SNLA, and interviews with site personnel. 85 refs., 49 figs., 48 tabs.

  8. Ruiz Volcano: Preliminary report

    NASA Astrophysics Data System (ADS)

    Ruiz Volcano, Colombia (4.88°N, 75.32°W). All times are local (= GMT -5 hours).An explosive eruption on November 13, 1985, melted ice and snow in the summit area, generating lahars that flowed tens of kilometers down flank river valleys, killing more than 20,000 people. This is history's fourth largest single-eruption death toll, behind only Tambora in 1815 (92,000), Krakatau in 1883 (36,000), and Mount Pelée in May 1902 (28,000). The following briefly summarizes the very preliminary and inevitably conflicting information that had been received by press time.

  9. The revised human liver cytochrome P450 "Pie": absolute protein quantification of CYP4F and CYP3A enzymes using targeted quantitative proteomics.

    PubMed

    Michaels, Scott; Wang, Michael Zhuo

    2014-08-01

    The CYP4F subfamily of enzymes has been identified recently to be involved in the metabolism of endogenous compounds (arachidonic acid and leukotriene B4), nutrients (vitamins K1 and E), and xenobiotics (pafuramidine and fingolimod). CYP4F2 and CYP4F3B are reported to be expressed in the human liver. However, absolute concentrations of these enzymes in human liver microsomes (HLMs) and their interindividual variability have yet to be determined because of the lack of specific antibodies. Here, an liquid chromatography with tandem mass spectrometry (LC-MS/MS)-based targeted quantitative proteomic approach was employed to determine the absolute protein concentrations of CYP4F2 and CYP4F3B compared with CYP3A in two panels of HLMs (n = 31). As a result, the human hepatic cytochrome P450 (P450) "pie" has been revised to include the contribution of CYP4F enzymes, which amounts to 15% of the total hepatic cytochrome P450 enzymes. CYP4F3B displayed low interindividual variability (3.3-fold) in the HLM panels whereas CYP4F2 displayed large variability (21-fold). However, CYP4F2 variability decreased to 3.4-fold if the two donors with the lowest expression were excluded. In contrast, CYP3A exhibited 29-fold interindividual variability in the same HLM panels. The proposed marker reaction for CYP4F enzymes pafuramidine/DB289 M1 formation did not correlate with CYP4F protein content, suggesting alternate metabolic pathways for DB289 M1 formation in HLMs. In conclusion, CYP4F enzymes are highly expressed in the human liver and their physiologic and pharmacologic roles warrant further investigation.

  10. [Estimation of heritability and repeatability of resting metabolic rate in birds, with free-living pied flycatchers Ficedula hypoleuca (Aves: Passeriformes) as an example].

    PubMed

    Bushuev, A V; Kerimov, A B; Ivankina, E V

    2010-01-01

    Estimates of a trait heritability and repeatability can get at an idea of its usefulness for being an individual characteristic and its ability to change under selection pressure. Heritability and repeatability of energetic parameters still poorly studied in birds. The most important physiological characteristic of homoiotherms is resting metabolic rate (RMR), which, in the absence of productive processes, does not exceed basal metabolic rate (BMR). We estimated BMR repeatability in free-living pied flycatchers in Moscow Region (55 degrees 44' N, 36 degrees 51' E; 1992-2008) and Tomsk (56 degrees 20' N, 84 degrees 56' E; 2008-2009) populations over intervals from 40 days to 3 years. In Moscow Region population, BMR repeatability amounted to tau = 0.34 +/- 0.10 (n=80) if measured over 1 year interval, tau = 0.60 +/- 0.15 (n=19) if measured over 2 years interval, and tau = 0.85 +/- 0.13 (n=6) if measured over 3 years interval providing that consecutive BMR measurements were done in the same period of reproductive season. In Tomsk population, BMR repeatability, measured over 1 year interval, amounted to tau = 0.49 +/- 0.11 (n=50). Repeatability is a measure of a trait constancy and sets the upper limit of its heritability. To estimate RMR heritability, cross-fostering experiments have been conducted in 2003-2005 with flycatchers of Moscow Region population. RMR of chicks positively correlated with BMR of their biological fathers, whereas such correlation in metabolic rates between chicks and their foster fathers was absent. The RMR heritability estimate turned out to be h2 = 0.43 +/- 0.17 (n=210). The obtained estimates of heritability and repeatability of fundamental energetic traits are rather high for physiological features. This suggests the existence of a potential for direct selection on BMR and evolutionary stable diversity of avian populations with regard to basal metabolic rate.

  11. A PRELIMINARY JUPITER MODEL

    SciTech Connect

    Hubbard, W. B.; Militzer, B.

    2016-03-20

    In anticipation of new observational results for Jupiter's axial moment of inertia and gravitational zonal harmonic coefficients from the forthcoming Juno orbiter, we present a number of preliminary Jupiter interior models. We combine results from ab initio computer simulations of hydrogen–helium mixtures, including immiscibility calculations, with a new nonperturbative calculation of Jupiter's zonal harmonic coefficients, to derive a self-consistent model for the planet's external gravity and moment of inertia. We assume helium rain modified the interior temperature and composition profiles. Our calculation predicts zonal harmonic values to which measurements can be compared. Although some models fit the observed (pre-Juno) second- and fourth-order zonal harmonics to within their error bars, our preferred reference model predicts a fourth-order zonal harmonic whose absolute value lies above the pre-Juno error bars. This model has a dense core of about 12 Earth masses and a hydrogen–helium-rich envelope with approximately three times solar metallicity.

  12. AGR-2 Irradiated Test Train Preliminary Inspection and Disassembly First Look

    SciTech Connect

    Ploger, Scott; Demkowciz, Paul; Harp, Jason

    2015-05-01

    The AGR 2 irradiation experiment began in June 2010 and was completed in October 2013. The test train was shipped to the Materials and Fuels Complex in July 2014 for post-irradiation examination (PIE). The first PIE activities included nondestructive examination of the test train, followed by disassembly of the test train and individual capsules and detailed inspection of the capsule contents, including the fuel compacts and their graphite fuel holders. Dimensional metrology was then performed on the compacts, graphite holders, and steel capsule shells. AGR 2 disassembly and metrology were performed with the same equipment used successfully on AGR 1 test train components. Gamma spectrometry of the intact test train gave a preliminary look at the condition of the interior components. No evidence of damage to compacts or graphite components was evident from the isotopic and gross gamma scans. Disassembly of the AGR 2 test train and its capsules was conducted rapidly and efficiently by employing techniques refined during the AGR 1 disassembly campaign. Only one major difficulty was encountered while separating the test train into capsules when thermocouples (of larger diameter than used in AGR 1) and gas lines jammed inside the through tubes of the upper capsules, which required new tooling for extraction. Disassembly of individual capsules was straightforward with only a few minor complications. On the whole, AGR 2 capsule structural components appeared less embrittled than their AGR 1 counterparts. Compacts from AGR 2 Capsules 2, 3, 5, and 6 were in very good condition upon removal. Only relatively minor damage or markings were visible using high resolution photographic inspection. Compact dimensional measurements indicated radial shrinkage between 0.8 to 1.7%, with the greatest shrinkage observed on Capsule 2 compacts that were irradiated at higher temperature. Length shrinkage ranged from 0.1 to 0.9%, with by far the lowest axial shrinkage on Capsule 3 compacts

  13. GeoLab—A habitat-based laboratory for preliminary examination of geological samples

    NASA Astrophysics Data System (ADS)

    Evans, Cynthia A.; Calaway, Michael J.; Sue Bell, Mary; Young, Kelsey E.

    2013-10-01

    GeoLab is a prototype geological laboratory designed for deployment and testing during NASA's analog demonstrations. Scientists at NASA's Johnson Space Center (JSC) built GeoLab as part of a technology project to support the development of science operational concepts for future planetary surface missions. It was integrated into NASA's Habitat Demonstration Unit 1 - Pressurized Excursion Module (HDU1-PEM), a first generation exploration habitat test bed. As a test bed, GeoLab provides a high fidelity working space for crewmembers to perform preliminary examination and characterization of geologic samples. The GeoLab concept builds from the hardware and cleanroom protocols used in JSC's Astromaterials Sample Curation laboratories. The main hardware component of the GeoLab is a custom-built glovebox, constructed from stainless steel and polycarbonate, and built to provide a positive pressure nitrogen environment. The glovebox is mounted onto the habitat's structural ribs; the unique shape (trapezoidal prism) fits within a pie-shaped section of the cylindrical habitat. A key innovation of GeoLab is the mechanism for transferring samples into the glovebox: three antechambers (airlocks) that pass through the shell of the habitat. These antechambers allow geologic samples to enter and exit the main glovebox chamber directly from (and to) the outside, thereby controlling contamination from inside the habitat. The glovebox is configured to include imaging systems, instrumentation, and computer controls. The first field trials tested a simple configuration including a microscope, a commercially available handheld X-ray Fluorescence instrument, network cameras, and simple sample handling tools inside the glovebox. We present results from the initial field trials of GeoLab during the 2010 Desert Research and Technology Studies (Desert RATS) planetary analog test near Flagstaff, AZ. These field tests examined the general operations of the GeoLab hardware and the crew

  14. Preliminary reference Earth model

    NASA Astrophysics Data System (ADS)

    Dziewonski, Adam M.; Anderson, Don L.

    1981-06-01

    A large data set consisting of about 1000 normal mode periods, 500 summary travel time observations, 100 normal mode Q values, mass and moment of inertia have been inverted to obtain the radial distribution of elastic properties, Q values and density in the Earth's interior. The data set was supplemented with a special study of 12 years of ISC phase data which yielded an additional 1.75 × 10 6 travel time observations for P and S waves. In order to obtain satisfactory agreement with the entire data set we were required to take into account anelastic dispersion. The introduction of transverse isotropy into the outer 220 km of the mantle was required in order to satisfy the shorter period fundamental toroidal and spheroidal modes. This anisotropy also improved the fit of the larger data set. The horizontal and vertical velocities in the upper mantle differ by 2-4%, both for P and S waves. The mantle below 220 km is not required to be anisotropic. Mantle Rayleigh waves are surprisingly sensitive to compressional velocity in the upper mantle. High S n velocities, low P n velocities and a pronounced low-velocity zone are features of most global inversion models that are suppressed when anisotropy is allowed for in the inversion. The Preliminary Reference Earth Model, PREM, and auxiliary tables showing fits to the data are presented.

  15. Preliminary Analysis of Photoreading

    NASA Technical Reports Server (NTRS)

    McNamara, Danielle S.

    2000-01-01

    The purpose of this project was to provide a preliminary analysis of a reading strategy called PhotoReading. PhotoReading is a technique developed by Paul Scheele that claims to increase reading rate to 25,000 words per minute (Scheele, 1993). PhotoReading itself involves entering a "relaxed state" and looking at, but not reading, each page of a text for a brief moment (about I to 2 seconds). While this technique has received attention in the popular press, there had been no objective examinations of the technique's validity. To examine the effectiveness of PhotoReading, the principal investigator (i.e., trainee) participated in a PhotoReading workshop to learn the technique. Parallel versions of two standardized and three experimenter-created reading comprehension tests were administered to the trainee and an expert user of the PhotoReading technique to compare the use of normal reading strategies and the PhotoReading technique by both readers. The results for all measures yielded no benefits of using the PhotoReading technique. The extremely rapid reading rates claimed by PhotoReaders were not observed; indeed, the reading rates were generally comparable to those for normal reading. Moreover, the PhotoReading expert generally showed an increase in reading time when using the PhotoReading technique in comparison to when using normal reading strategies to process text. This increase in reading time when PhotoReading was accompanied by a decrease in text comprehension.

  16. Enhanced preliminary assessment

    SciTech Connect

    Not Available

    1992-02-01

    An Enhanced Preliminary Assessment was conducted at Fort Benjamin Harrison (FBH) Indiana, which is located approximately 12 miles from downtown Indianapolis in Lawrence Township, Marion County. FBH contains 2,501 acres, of which approximately 1,069 acres is covered by woodlands. Activities at FBH include administration, training, housing, and support. Sensitive environments at FBH include wetlands, habitat areas for the endangered Indiana bat, endangered plants, and historically and archeologically significant areas. FBH is a U.S. Army Soldier Support Center under the jurisdiction of the U.S. Army Training and Doctrine Command (TRADOC). Based on information obtained during and subsequent to a site visit (15 through 18 October 1991), 36 types of Areas Requiring Environmental Evaluation (AREEs) were identified and grouped by the following categories: Facility Operations; Maintenance/Fueling Operations; Water Treatment Operations; Training Areas; Hazardous Materials Storage/Waste Handling Areas; Sanitary Wastewater Treatment Plants; Storage Tanks; Landfills/Incinerators; Medical Facilities; Burn Pit Areas; Spill Areas; Ammunition Storage; Coal Storage; and Facility-wide AREEs. This report presents a summary of findings for each AREE and recommendations for further action.

  17. Stardust Interstellar Preliminary Examination (ISPE)

    NASA Astrophysics Data System (ADS)

    Westphal, A. J.; Allen, C.; Bajt, S.; Basset, R.; Bastien, R.; Bechtel, H.; Bleuet, P.; Borg, J.; Brenker, F.; Bridges, J.; Brownlee, D. E.; Burchell, M.; Burghammer, M.; Butterworth, A. L.; Cloetens, P.; Cody, G.; Ferroir, T.; Floss, C.; Flynn, G. J.; Frank, D.; Gainsforth, Z.; Grün, E.; Hoppe, P.; Kearsley, A.; Lemelle, L.; Leroux, H.; Lettieri, R.; Marchant, W.; Mendez, B.; Nittler, L. R.; Ogliore, R.; Postberg, F.; Sandford, S. A.; Schmitz, S.; Silversmit, G.; Simionovici, A.; Srama, R.; Stadermann, F. J.; Stephan, T.; Stroud, R. M.; Susini, J.; Sutton, S.; Trieloff, M.; Tsou, P.; Tsuchiyama, A.; Tyliczszak, T.; Vekemans, B.; Vincze, L.; Warren, J.; Zolensky, M. E.

    2009-03-01

    The Stardust Interstellar Preliminary Examination (ISPE) is a three-year effort to characterize the Stardust interstellar dust collection and collector using non-destructive techniques. We summarize the status of the ISPE.

  18. 32 CFR 651.49 - Preliminary phase.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Preliminary phase. 651.49 Section 651.49... Preliminary phase. In the preliminary phase, the proponent agency or office identifies, as early as possible... tentative list of the affected parties to be notified. A key part of this preliminary identification is...

  19. Genetic correlations between type and test-day milk yield in small dual-purpose cattle populations: The Aosta Red Pied breed as a case study.

    PubMed

    Mazza, Serena; Guzzo, Nadia; Sartori, Cristina; Mantovani, Roberto

    2016-10-01

    This study aimed at estimating the relationships between linear type traits and milk production in the dual-purpose Aosta Red Pied (ARP) cattle breed, by expressing type traits as factor scores with the same biological meaning of the individual traits. Factor analysis was applied to individual type traits for muscularity and udder of 32,275 first-parity ARP cows, obtaining 3 factor scores for individual muscularity (F1), udder side (F2), and udder conformation (F3). Data from 169,008 test-day records of milk, fat, and protein yield (kg), belonging to the first 3 lactations of 16,605 cows, were also analyzed. After obtaining genetic parameters for both morphological factors and milk production traits through a series of AIREML single-trait models, bivariate analyses were performed on a data set accounting for 201,283 records of 35,530 cows, to assess the phenotypic and genetic correlations among all factor scores and milk yield traits. The heritability estimates obtained proved to be moderate for both groups of traits, ranging from 0.132 (fat) to 0.314 (F1). Muscularity factor showed moderate and negative genetic correlations (ra) with udder size (-0.376) and udder conformation (0.214) factors. A low and negative ra was found between udder factors. Strong and positive ra were found among all the 3 milk production traits and F 0010 (ra≥0.597). Negative ra with milk traits were obtained for both F 0005 and F3, ranging from -0.417 to -0.221. Phenotypic correlations were lower than the genetic ones, and sometimes close to zero. The antagonism between milk production and meat attitude traits suggests that great attention should be paid in assigning proper weight to the traits, comprising functional traits such as udder conformation, included in selection indices for the dual-purpose breed. The ra obtained for factor scores are consistent with previous estimates for the corresponding individual type traits, and this confirms the possible use of factor analysis to

  20. Detrital zircon analysis from the Neoproterozoic-Cambrian sedimentary cover (Cuyania terrane), Sierra de Pie de Palo, Argentina: Evidence of a rift and passive margin system?

    NASA Astrophysics Data System (ADS)

    Naipauer, M.; Vujovich, G. I.; Cingolani, C. A.; McClelland, W. C.

    2010-03-01

    Metamorphic basement and its Neoproterozoic to Cambrian cover exposed in the Sierra de Pie de Palo, a basement block of the Sierras Pampeanas in Argentina, lie within the Cuyania terrane. Detrital zircon analysis of the cover sequence which includes, in ascending order, the El Quemado, La Paz, El Desecho, and Angacos Formations of the Caucete Group indicate a Laurentian origin for the Cuyania terrane. The lower section represented by the El Quemado and La Paz Formations is interpreted as having an igneous source related to a rift setting similar to that envisioned for the southern and eastern margins of Laurentia at approximately 550 Ma. The younger strata of the El Desecho Formation are correlative with the Cerro Totora Formation of the Precordillera, and both are products of rift sedimentation. Finally, the Angacos Formation and the correlative La Laja Formation of the Precordillera were deposited on the passive margin developed on the Cuyania terrane. The maximum depositional ages for the Caucete Group include ca. 550 Ma for the El Quemado Formation and ca. 531 Ma for the El Desecho Formation. Four different sediment sources areas were interpreted in the provenance analysis. The main source is crystalline basement dominated by early Mesoproterozoic igneous rocks related to the Granite-Rhyolite province of central and eastern Laurentia. Possible source areas for 1600 Ma metamorphic detrital zircons of the Caucete Group include the Yavapai-Mazatzal province ( ca. 1800-1600 Ma) of south-central to southwestern Laurentia. Younger Mesoproterozoic zircon is likely derived from Grenville-age medium- to high-grade metamorphic rocks and subordinate igneous rocks that form the basement of Cuyania as well as the southern Grenville province of Laurentia itself. Finally, Neoproterozoic igneous zircon in the Caucete Group records different magmatic pulses along the southern Laurentian margin during opening of Iapetus and break-up of Rodinia. Northwestern Cuyania terrane

  1. Segmentation: Slicing the Urban Pie.

    ERIC Educational Resources Information Center

    Keim, William A.

    1981-01-01

    Explains market segmentation and defines undifferentiated, concentrated, and differentiated marketing strategies. Describes in detail the marketing planning process at the Metropolitan Community Colleges. Focuses on the development and implementation of an ongoing recruitment program designed for the market segment composed of business employees.…

  2. Instant Pudding and Pie Filling

    DTIC Science & Technology

    1980-04-01

    0.57 Cocoa 12.46 Chocolate flavor enhancer 0.04 Artificial vanilla flavor 0.10 4 Food starch-modified, pre-gelatinized 14.32 Powdered vegetable... chocolate , vanilla and butterscotch flavors - were developed by NARADCOM, successfully production-tested, and subsequently procured through...powder of Example 1. These were chilled, sliced and served in the same manner as in Example 1. 8 Example 3 A chocolate flavored instant dessert

  3. SDI - pie in the sky

    SciTech Connect

    Arkin, W.M.

    1984-04-01

    Proponents of the controversial Strategic Defense Initiatives (SDI)reverse arrowfeel that the will to succeed will be as significant a factor as capability in their effort to make defense a popular concept. They reject the idea that a defensive system must be perfect, and want to loosen the hold of the Anti-Ballistic Missile (ABM) Treaty and Salt II. More than an improvement to deterrence, the goal of SDI is to make a technological leap over the Soviet Union to make its military investments obsolete. Scientists find research on defensive weapons more rewarding than work on offensive systems. Critics need to understand that the force of SDI is ideological in that it rejects the concept of mutually assured destruction (MAD) and concedes that nuclear war is possible.

  4. Preliminary Laboratory Measurements of the Boss Modulation Transfer Function.

    DTIC Science & Technology

    1981-06-05

    NOVS IOSOE190.rTE UNCLASSIFIED SECURITY CLASSIFICATIO~N OF THIS P& PIE fmhnw D.. ut e UNCLASSIFIED $CgUftv CL&Aqmaymm OF TWOI Pawav...these reasons, a focal length between 100 and 20b cm seemed appropriate. A single element, plano -convex lens with a focal length of 105 cm was finally

  5. Stardust Interstellar Preliminary Examination

    NASA Astrophysics Data System (ADS)

    Westphal, A.; Stardust Interstellar Preliminary Examation Team: http://www. ssl. berkeley. edu/~westphal/ISPE/

    2011-12-01

    A. J. Westphal, C. Allen, A. Ansari, S. Bajt, R. S. Bastien, H. A. Bechtel, J. Borg, F. E. Brenker, J. Bridges, D. E. Brownlee, M. Burchell, M. Burghammer, A. L. Butterworth, A. M. Davis, P. Cloetens, C. Floss, G. Flynn, D. Frank, Z. Gainsforth, E. Grün, P. R. Heck, J. K. Hillier, P. Hoppe, G. Huss, J. Huth, B. Hvide, A. Kearsley, A. J. King, B. Lai, J. Leitner, L. Lemelle, H. Leroux, R. Lettieri, W. Marchant, L. R. Nittler, R. Ogliore, F. Postberg, M. C. Price, S. A. Sandford, J.-A. Sans Tresseras, T. Schoonjans, S. Schmitz, G. Silversmit, A. Simionovici, V. A. Solé, R. Srama, T. Stephan, V. Sterken, J. Stodolna, R. M. Stroud, S. Sutton, M. Trieloff, P. Tsou, A. Tsuchiyama, T. Tyliszczak, B. Vekemans, L. Vincze, D. Zevin, M. E. Zolensky, >29,000 Stardust@home dusters ISPE author affiliations are at http://www.ssl.berkeley.edu/~westphal/ISPE/. In 2000 and 2002, a ~0.1m2 array of aerogel tiles and alumi-num foils onboard the Stardust spacecraft was exposed to the interstellar dust (ISD) stream for an integrated time of 200 days. The exposure took place in interplanetary space, beyond the orbit of Mars, and thus was free of the ubiquitous orbital debris in low-earth orbit that precludes effective searches for interstellar dust there. Despite the long exposure of the Stardust collector, <<100 ISD particles are expected to have been captured. The particles are thought to be ~1μm or less in size, and the total ISD collection is probably <10-6 by mass of the collection of cometary dust parti-cles captured in the Stardust cometary dust collector from the coma of the Jupiter-family comet Wild 2. Thus, although the first solid sample from the local interstellar medium is clearly of high interest, the diminutive size of the particles and the low numbers of particles present daunting challenges. Nevertheless, six recent developments have made a Preliminary Examination (PE) of this sample practical: (1) rapid automated digital optical scanning microscopy for three

  6. Quels agents incriminés dans les mycoses du pied ? Enquête auprès des diabétiques consultant au CHU Mohammed VI de Marrakech

    PubMed Central

    Chegour, Hakima; El Ansari, Nawal; El Mghari, Ghizlane; Tali, Abdelali; Zoughaghi, Laila; Sebbani, Majda; Amine, Mohamed

    2014-01-01

    Les infections mycosiques du pied constituent un motif fréquent de consultation chez les diabétiques, le diabète constituant à la fois un facteur favorisant et aggravant les lésions cutanéomuqueuses. L'objectif de ce travail était d'identifier la flore mycologique locale responsable des lésions du pied chez le diabétique et déterminer les facteurs favorisant la survenue de mycoses. Il s'agissait d'une étude transversale intéressant des diabétiques suivis en consultation; un prélèvement mycologique, avec examen direct et culture, a été réalisé devant toute suspicion clinique de lésion mycosique. Quatre-vingt-deux patients ont été inclus. L'hémoglobine glycosylée moyenne a été de9,2% ± 2,23. Un intertrigo inter orteil a été noté dans 90,2% des cas; l'examen mycologique était positif dans 64,8% des cas, avec 18 cas de Trichophyton rubrum et 11 cas de Candida albicans. Une atteinte unguéale a été suspectée chez 65,9% patients; la culture a mis en évidence un Trichosporon pathogène chez sept patients, un Candida albicansdans six cas, un Trichophyton rubrum dans quatre cas, avec trois cas de Trichophyton mentagrophytes et deux cas de Scytalidium dimidiatum. L’étude analytique, après confirmation mycologique, en fonction des principales caractéristiques des patients a montré que l'atteinte mycosique du pied est significativement corrélée au déséquilibre glycémique. Ce travail a montré la prédominance du Trichophyton rubrum dans les lésions d'intertrigo inter orteil et du Trichosporon dans les onychomycoses, avec une prédominance globale plus globale plus élevée du TR. PMID:25170372

  7. Concentrating solar collector subsystem: Preliminary design package

    NASA Technical Reports Server (NTRS)

    1977-01-01

    Preliminary design data are presented for a concentrating solar collector including an attitude controller. Provided are schedules, technical status, all documents required for preliminary design, and other program activities.

  8. Measuring Organizational Learning: A Preliminary Progress Report

    DTIC Science & Technology

    2010-08-01

    Contractor Report 2010-01 Measuring Organizational Learning : A Preliminary Progress Report Chris Winkler and Charles T...TITLE AND SUBTITLE Measuring Organizational Learning : A Preliminary Progress Report 5a. CONTRACT OR GRANT NUMBER W91WAW-07-C-0074 5b...Technical Publications Specialist (703) 602-8049 ii iii MEASURING ORGANIZATIONAL LEARNING : A PRELIMINARY

  9. 18 CFR 806.11 - Preliminary consultations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... COMMISSION REVIEW AND APPROVAL OF PROJECTS Application Procedure § 806.11 Preliminary consultations. (a) Any... Commission staff for an informal discussion of preliminary plans for the proposed project. To facilitate preliminary consultations, it is suggested that the project sponsor provide a general description of...

  10. 18 CFR 806.11 - Preliminary consultations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... COMMISSION REVIEW AND APPROVAL OF PROJECTS Application Procedure § 806.11 Preliminary consultations. (a) Any... Commission staff for an informal discussion of preliminary plans for the proposed project. To facilitate preliminary consultations, it is suggested that the project sponsor provide a general description of...

  11. Radioactive waste shredding: Preliminary evaluation

    SciTech Connect

    Soelberg, N.R.; Reimann, G.A.

    1994-07-01

    The critical constraints for sizing solid radioactive and mixed wastes for subsequent thermal treatment were identified via a literature review and a survey of shredding equipment vendors. The types and amounts of DOE radioactive wastes that will require treatment to reduce the waste volume, destroy hazardous organics, or immobilize radionuclides and/or hazardous metals were considered. The preliminary steps of waste receipt, inspection, and separation were included because many potential waste treatment technologies have limits on feedstream chemical content, physical composition, and particle size. Most treatment processes and shredding operations require at least some degree of feed material characterization. Preliminary cost estimates show that pretreatment costs per unit of waste can be high and can vary significantly, depending on the processing rate and desired output particle size.

  12. Lunar Excavator Preliminary Test Video

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This video shows a preliminary test of the boom and bucket wheel assembly of the lunar excavator prototype developed by the Center for Commercial Applications of Combustion at the Colorado School of Mines in Golden. According to Michael Duke, director for the center, the wheel on the end of the boom can dig up 45.36 kilograms (100 pounds) of dirt each hour which is several times the weight of the entire device.

  13. The MUNU experiment : preliminary results

    NASA Astrophysics Data System (ADS)

    Busto, J.; MUNU Collaboration

    2000-06-01

    The MUNU collaboration has built a detector to study overlineνe - e - scattering at low energy. From the results we expect to increase the sensitivity to the neutrino magnetic moment. The detector used, a 1 m 3 T.P.C. surrounded by an anti-Compton scintillator, is running at the Bugey nuclear plant. Some preliminary results will be presented in the following.

  14. A LTA flight research vehicle. [technology assessment, airships

    NASA Technical Reports Server (NTRS)

    Nebiker, F. R.

    1975-01-01

    An Airship Flight Research Program is proposed. Major program objectives are summarized and a Modernized Navy ZPG3W Airship recommended as the flight test vehicle. The origin of the current interest in modern airship vehicles is briefly discussed and the major benefits resulting from the flight research program described. Airship configurations and specifications are included.

  15. MOX LTA Fuel Cycle Analyses: Nuclear and Radiation Safety

    SciTech Connect

    Pavlovitchev, A.M.

    2001-09-28

    Tasks of nuclear safety assurance for storage and transport of fresh mixed uranium-plutonium fuel of the VVER-1000 reactor are considered in the view of 3 MOX LTAs introduction into the core. The precise code MCU that realizes the Monte Carlo method is used for calculations.

  16. Apport de l’écho-doppler artériel des membres inférieurs dans la prise en charge du pied diabétique à l'hôpital Saint-Jean de Dieu de Thiès (Sénégal)

    PubMed Central

    Dia, Aliou Amadou; Affangla, Désiré Alain; Dione, Jean-Michel; Akpo, Géraud; Mbengue, Marie; Ka, Mamadou Mourtalla; Diop, Bernard Marcel

    2015-01-01

    Introduction Le pied diabétique se définit comme l'ensemble des manifestations trophiques du pied survenant chez le diabétique par atteinte nerveuse, artérielle et ou infectieuse. Le pied diabétique est un problème majeur de santé publique à l’échelle mondiale avec un taux d'amputation de membres inférieurs très élevé. L’écho-doppler artériel des membres inférieurs est de nos jours incontournable dans la prise en charge du pied diabétique. Le but de cette étude est de montrer la place prépondérante qu'occupe l’écho-doppler artériel dans le bilan lésionnel du pied diabétique. Méthodes Nous avons mené une étude rétrospective monocentrique incluant 46 patients sur une période de 24 mois, de mars 2012 à mars 2014 à l'hôpital Saint-Jean de Dieu, un des deux hôpitaux de référence de la région de Thiès, doté depuis juillet 2011 d'un centre moderne de traitement du diabète et des maladies cardio-métaboliques (Diabcarmet). Dans les critères d'inclusion, nous avons sélectionné tous les patients diabétiques adressés pour un écho-doppler artériel des membres inférieurs dans le cadre d'une prise en charge du pied diabétique. Etaient exclus de l’étude, les patients artéritiques non-diabétiques et les patients diabétiques asymptomatiques référés pour un bilan écho-doppler de routine. Résultats Le sex-ratio était de 1.42 (27 hommes pour 19 femmes). L’âge moyen des patients était de 62,86 ans avec des extrêmes de 23 et 88 ans. 60% des patients (n=28) étaient âgés entre 50 et 70 ans. Le diabète de type 2 était retrouvé chez 95% des patients (n=44) alors que le diabète de type 1 représentait 5% (n=2). La moyenne d’évolution du diabète était estimée à 8 ans, avec des extrêmes de 2 et 20 ans. On notait une atteinte du pied droit chez 24 patients, une atteinte du pied gauche chez 18 patients et une atteinte bilatérale chez 4 patients. La plupart du temps, les lésions du pied diabétique survenaient

  17. Preliminary ECLSS waste water model

    NASA Technical Reports Server (NTRS)

    Carter, Donald L.; Holder, Donald W., Jr.; Alexander, Kevin; Shaw, R. G.; Hayase, John K.

    1991-01-01

    A preliminary waste water model for input to the Space Station Freedom (SSF) Environmental Control and Life Support System (ECLSS) Water Processor (WP) has been generated for design purposes. Data have been compiled from various ECLSS tests and flight sample analyses. A discussion of the characterization of the waste streams comprising the model is presented, along with a discussion of the waste water model and the rationale for the inclusion of contaminants in their respective concentrations. The major objective is to establish a methodology for the development of a waste water model and to present the current state of that model.

  18. Preliminary considerations concerning actinide solubilities

    SciTech Connect

    Newton, T.W.; Bayhurst, B.P.; Daniels, W.R.; Erdal, B.R.; Ogard, A.E.

    1980-01-01

    Work at the Los Alamos Scientific Laboratory on the fundamental solution chemistry of the actinides has thus far been confined to preliminary considerations of the problems involved in developing an understanding of the precipitation and dissolution behavior of actinide compounds under environmental conditions. Attempts have been made to calculate solubility as a function of Eh and pH using the appropriate thermodynamic data; results have been presented in terms of contour maps showing lines of constant solubility as a function of Eh and pH. Possible methods of control of the redox potential of rock-groundwater systems by the use of Eh buffers (redox couples) is presented.

  19. Dielectric cure monitoring: Preliminary studies

    NASA Technical Reports Server (NTRS)

    Goldberg, B. E.; Semmel, M. L.

    1984-01-01

    Preliminary studies have been conducted on two types of dielectric cure monitoring systems employing both epoxy resins and phenolic composites. An Audrey System was used for 23 cure monitoring runs with very limited success. Nine complete cure monitoring runs have been investigated using a Micromet System. Two additional measurements were performed to investigate the Micromet's sensitivity to water absorption in a post-cure carbon-phenolic material. While further work is needed to determine data significance, the Micromet system appears to show promise as a feedback control device during processing.

  20. Topaz II preliminary safety assessment

    NASA Astrophysics Data System (ADS)

    Marshall, Albert C.; Standley, Vaughn; Voss, Susan S.; Haskin, Eric

    1993-01-01

    The Strategic Defense Initiative Organization (SDIO) decided to investigate the possibility of launching a Russian Topaz II space nuclear power system. A preliminary safety assessment was conducted to determine whether or not a space mission could be conducted safely and within budget constraints. As part of this assessment, a safety policy and safety functional requirements were developed to guide both the safety assessment and future Topaz II activities. A review of the Russian flight safety program was conducted and documented. Our preliminary safety assessment included a top level event tree, neutronic analysis of normal and accident configurations, an evaluation of temperature coefficients of reactivity, a reentry and disposal analysis, and analysis of postulated launch abort impact accidents, and an analysis of postulated propellant fire and explosion accidents. Based on the assessment, it appears that it will be possible to safely launch the Topaz II system in the U.S. with some possible system modifications. The principal system modifications will probably include design changes to preclude water flooded criticality and to assure intact reentry.

  1. Preliminary Investigation of a Paraglider

    NASA Technical Reports Server (NTRS)

    Rogallo, Francis M.; Lowry, John G.; Croom, Delwin R.; Taylor, Robert T.

    1960-01-01

    A preliminary investigation of the aerodynamic and control characteristics of a flexible glider similar to a parachute in construction has been made at the Langley Research Center to evaluate its capabilities as a reentry glider. Preliminary weight estimates of the proposed vehicle indicate that such a structure can be made with extremely low wing loading. Maximum temperatures during the reentry maneuver might be held as low as about 1,500 F. The results of wind-tunnel and free-glide tests show that the glider when constructed of nonporous material performed extremely well at subsonic speeds and could be flown at angles of attack from about 200 to 900. At supersonic speeds the wing showed none of the unfavorable tendencies exhibited by conventional parachutes at these speeds, such as squidding and breathing. Several methods of packing and deploying the glider have been successfully demonstrated. The results of this study indicate that this flexible-lifting-surface concept may provide a lightweight controllable paraglider for manned space vehicles.

  2. Descent Advisor Preliminary Field Test

    NASA Technical Reports Server (NTRS)

    Green, Steven M.; Vivona, Robert A.; Sanford, Beverly

    1995-01-01

    A field test of the Descent Advisor (DA) automation tool was conducted at the Denver Air Route Traffic Control Center in September 1994. DA is being developed to assist Center controllers in the efficient management and control of arrival traffic. DA generates advisories, based on trajectory predictions, to achieve accurate meter-fix arrival times in a fuel efficient manner while assisting the controller with the prediction and resolution of potential conflicts. The test objectives were: (1) to evaluate the accuracy of DA trajectory predictions for conventional and flight-management system equipped jet transports, (2) to identify significant sources of trajectory prediction error, and (3) to investigate procedural and training issues (both air and ground) associated with DA operations. Various commercial aircraft (97 flights total) and a Boeing 737-100 research aircraft participated in the test. Preliminary results from the primary test set of 24 commercial flights indicate a mean DA arrival time prediction error of 2.4 seconds late with a standard deviation of 13.1 seconds. This paper describes the field test and presents preliminary results for the commercial flights.

  3. Topaz II preliminary safety assessment

    SciTech Connect

    Marshall, A.C. ); Standley, V. ); Voss, S.S. ); Haskin, E. . Dept. of Chemical and Nuclear Engineering)

    1992-01-01

    The Strategic Defense Initiative Organization (SDIO) decided to investigate the possibility of launching a Russian Topaz 11 space nuclear power system. A preliminary safety assessment was conducted to determine whether or not a space mission could be conducted safely and within budget constraints. As part of this assessment, a safety policy and safety functional requirements were developed to guide both the safely assessment and future Topaz II activities. A review of the Russian flight safety program was conducted and documented. Our preliminary safety assessment included a top level event tree, neutronic analysis of normal and accident configurations, an evaluation of temperature coefficients of reactivity, a reentry and disposal analysis, and analysis of postulated launch abort impact accidents, and an analysis of postulated propellant fire and explosion accidents. Based on the assessment, it appears that it will be possible to safely launch the Topaz II system in the US with some possible system modifications. The principal system modifications will probably include design changes to preclude water flooded criticality and to assure intact reentry.

  4. Topaz II preliminary safety assessment

    SciTech Connect

    Marshall, A.C. ); Standley, V. ); Voss, S.S. ); Haskin, E. )

    1993-01-10

    The Strategic Defense Initiative Organization (SDIO) decided to investigate the possibility of launching a Russian Topaz II space nuclear power system. A preliminary safety assessment was conducted to determine whether or not a space mission could be conducted safely and within budget constraints. As part of this assessment, a safety policy and safety functional requirements were developed to guide both the safety assessment and future Topaz II activities. A review of the Russian flight safety program was conducted and documented. Our preliminary safety assessment included a top level event tree, neutronic analysis of normal and accident configurations, an evaluation of temperature coefficients of reactivity, a reentry and disposal analysis, and analysis of postulated launch abort impact accidents, and an analysis of postulated propellant fire and explosion accidents. Based on the assessment, it appears that it will be possible to safely launch the Topaz II system in the U.S. with some possible system modifications. The principal system modifications will probably include design changes to preclude water flooded criticality and to assure intact reentry.

  5. Land Tenure Adjustment Project. Preliminary Draft Environmental Impact Statement/Report

    DTIC Science & Technology

    1987-04-16

    Desert District, Riverside, California ), Department of Defense (Air Force Flight Test Center - Edwards Air Force Base and George Air Force Base) and San ...The Land Tenure Adjustment (LTA) Project stems from concern of the Bureau of Land Management (Barstow and Ridgecrest Resource Areas, California ...Bernardino County, California . Of principal concern to the three agencies is the current checkerboard landownership pattern over the 2.8 million acres

  6. 37 CFR 1.115 - Preliminary amendments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... amendment unduly interferes with the preparation of a first Office action in an application. Factors that... first Office action as of the date of receipt (§ 1.6) of the preliminary amendment by the Office; and... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Preliminary amendments....

  7. 37 CFR 1.115 - Preliminary amendments.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... amendment unduly interferes with the preparation of a first Office action in an application. Factors that... first Office action as of the date of receipt (§ 1.6) of the preliminary amendment by the Office; and... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Preliminary amendments....

  8. 23 CFR 645.109 - Preliminary engineering.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Preliminary engineering. 645.109 Section 645.109 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS UTILITIES Utility Relocations, Adjustments, and Reimbursement § 645.109 Preliminary engineering. (a)...

  9. 23 CFR 645.109 - Preliminary engineering.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Preliminary engineering. 645.109 Section 645.109 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS UTILITIES Utility Relocations, Adjustments, and Reimbursement § 645.109 Preliminary engineering. (a)...

  10. 23 CFR 645.109 - Preliminary engineering.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 23 Highways 1 2012-04-01 2012-04-01 false Preliminary engineering. 645.109 Section 645.109 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS UTILITIES Utility Relocations, Adjustments, and Reimbursement § 645.109 Preliminary engineering. (a)...

  11. 23 CFR 645.109 - Preliminary engineering.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Preliminary engineering. 645.109 Section 645.109 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS UTILITIES Utility Relocations, Adjustments, and Reimbursement § 645.109 Preliminary engineering. (a)...

  12. 23 CFR 645.109 - Preliminary engineering.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false Preliminary engineering. 645.109 Section 645.109 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS UTILITIES Utility Relocations, Adjustments, and Reimbursement § 645.109 Preliminary engineering. (a)...

  13. 18 CFR 1b.6 - Preliminary investigations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Preliminary investigations. 1b.6 Section 1b.6 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.6 Preliminary investigations....

  14. 18 CFR 1b.6 - Preliminary investigations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Preliminary investigations. 1b.6 Section 1b.6 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.6 Preliminary investigations....

  15. 32 CFR 1801.11 - Preliminary information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Preliminary information. 1801.11 Section 1801.11 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER PUBLIC RIGHTS UNDER THE PRIVACY ACT OF 1974 Filing Of Privacy Act Requests § 1801.11 Preliminary...

  16. 32 CFR 1801.11 - Preliminary information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Preliminary information. 1801.11 Section 1801.11 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER PUBLIC RIGHTS UNDER THE PRIVACY ACT OF 1974 Filing Of Privacy Act Requests § 1801.11 Preliminary...

  17. 32 CFR 1801.11 - Preliminary information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Preliminary information. 1801.11 Section 1801.11 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER PUBLIC RIGHTS UNDER THE PRIVACY ACT OF 1974 Filing Of Privacy Act Requests § 1801.11 Preliminary...

  18. 32 CFR 1801.11 - Preliminary information.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false Preliminary information. 1801.11 Section 1801.11 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER PUBLIC RIGHTS UNDER THE PRIVACY ACT OF 1974 Filing Of Privacy Act Requests § 1801.11 Preliminary...

  19. 32 CFR 1801.11 - Preliminary information.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Preliminary information. 1801.11 Section 1801.11 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER PUBLIC RIGHTS UNDER THE PRIVACY ACT OF 1974 Filing Of Privacy Act Requests § 1801.11 Preliminary...

  20. 18 CFR 1b.6 - Preliminary investigations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Preliminary investigations. 1b.6 Section 1b.6 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.6 Preliminary investigations....

  1. 18 CFR 1b.6 - Preliminary investigations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Preliminary investigations. 1b.6 Section 1b.6 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.6 Preliminary investigations....

  2. 18 CFR 1b.6 - Preliminary investigations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Preliminary investigations. 1b.6 Section 1b.6 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.6 Preliminary investigations....

  3. 18 CFR 806.11 - Preliminary consultations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... any proposed structures, anticipated water needs, and the environmental impacts. (b) Preliminary... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Preliminary consultations. 806.11 Section 806.11 Conservation of Power and Water Resources SUSQUEHANNA RIVER...

  4. 18 CFR 806.11 - Preliminary consultations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... any proposed structures, anticipated water needs, and the environmental impacts. (b) Preliminary... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Preliminary consultations. 806.11 Section 806.11 Conservation of Power and Water Resources SUSQUEHANNA RIVER...

  5. 18 CFR 806.11 - Preliminary consultations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... any proposed structures, anticipated water needs, and the environmental impacts. (b) Preliminary... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Preliminary consultations. 806.11 Section 806.11 Conservation of Power and Water Resources SUSQUEHANNA RIVER...

  6. 40 CFR 158.345 - Preliminary analysis.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Preliminary analysis. 158.345 Section 158.345 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Product Chemistry § 158.345 Preliminary analysis. (a) If the product is produced...

  7. 40 CFR 158.345 - Preliminary analysis.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Preliminary analysis. 158.345 Section 158.345 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Product Chemistry § 158.345 Preliminary analysis. (a) If the product is produced...

  8. 40 CFR 158.345 - Preliminary analysis.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Preliminary analysis. 158.345 Section 158.345 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Product Chemistry § 158.345 Preliminary analysis. (a) If the product is produced...

  9. 40 CFR 158.345 - Preliminary analysis.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Preliminary analysis. 158.345 Section 158.345 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Product Chemistry § 158.345 Preliminary analysis. (a) If the product is produced...

  10. 32 CFR 1901.11 - Preliminary information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Preliminary information. 1901.11 Section 1901.11 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC RIGHTS UNDER THE PRIVACY ACT OF 1974 Filing of Privacy Act Requests § 1901.11 Preliminary information....

  11. 32 CFR 1901.11 - Preliminary information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Preliminary information. 1901.11 Section 1901.11 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY PUBLIC RIGHTS UNDER THE PRIVACY ACT OF 1974 Filing of Privacy Act Requests § 1901.11 Preliminary information....

  12. Plutonium Immobilization Can Loading Preliminary Specifications

    SciTech Connect

    Kriikku, E.

    1998-11-25

    This report discusses the Plutonium Immobilization can loading preliminary equipment specifications and includes a process block diagram, process description, equipment list, preliminary equipment specifications, plan and elevation sketches, and some commercial catalogs. This report identifies loading pucks into cans and backfilling cans with helium as the top priority can loading development areas.

  13. Surveyor 3 Preliminary Science Results

    NASA Technical Reports Server (NTRS)

    1967-01-01

    Surveyor III soft-landed on the Moon at 00:04 GMT on April 20, 1967. Data obtained have significantly increased our knowledge of the Moon. The Surveyor III spacecraft was similar to Surveyor I; the only major change in scientific instrumentation was the addition of a soil mechanics surface sampler. Surveyor III results at this preliminary evaluation of data give valuable information about the relation between the surface skin of under-dense material responsible for the photometric properties and the deeper layers of material whose properties resemble those of ordinary terrestrial soils. In addition, they provide new insight into the relation between the general lunar surface as seen by Surveyor I and the interior of a large subdued crater. The new results have also contributed to our understanding of the mechanism of downhill transport. Many critical questions cannot, however, be answered until final reduction of experimental data.

  14. Psychohistory and Slavery: Preliminary Issues.

    PubMed

    Adams, Kenneth Alan

    2015-01-01

    "Psychohistory and Slavery: Preliminary Issues," begins an examination of slavery in the antebellum South. The paper suggests that how slavery and the group-fantasy of white male supremacy were perpetuated among slaveholders is a question of fundamental importance for psychohistorians. The family and childrearing are the focus of attention. Given the ferocity of slavery, it is argued that the psychological and emotional consequences of this barbarism were not limited to the slaves themselves, but had significant impact on the slaveholders as well-their parenting, their children, and their children's parenting of the next generation. In each generation the trauma of slavery was injected into slaveholder children and became a fundamental component of elite Southern personality.

  15. Genesis Preliminary Examination: Ellipsometry Overview

    NASA Technical Reports Server (NTRS)

    Stansbery, E. K.; McNamara, K. M.

    2005-01-01

    The Genesis spacecraft returned to Earth on September 8, 2004, experiencing a non-nominal reentry in which both the drogue and main parachutes failed to deploy causing the capsule to impact the surface of the UTTR desert at a speed of approximately 310 kph (193 mph). The impact caused severe damage to the capsule and a breach of the science canister in the field. The science canister was recovered and transported to the cleanroom at UTTR within approximately 8 hours of reentry. Although the ground water table did not rise to canister level before removal, damp soil and debris from the heat shield and other spacecraft components did enter the canister and contaminate some collector surfaces. The objective of preliminary examination of the Genesis collectors is to provide the science community with the information necessary to request the most useful samples for their analysis.

  16. Preliminary results of UCN τ

    NASA Astrophysics Data System (ADS)

    Pattie, Robert; UCNtau Collaboration

    2017-01-01

    There is currently a 4 σ discrepancy between measurements of the neutron lifetime performed using cold neutron beams and those performed with ultracold neutron (UCN) storage vessels. The UCN τ experiment uses an asymmetric magneto-gravitational UCN trap with in situ counting of surviving neutrons to measure the neutron lifetime. This design eliminates a major systematic of previous bottle experiments related to the loss of UCN on material trap walls and with unloading neutrons from the storage vessel. A new in situ detection system was used in the 2015-2016 run that was able to measure the population of surviving UCN at different heights in the trap, providing important information on spectral evolution. Understanding the behavior of quasi-bound UCN in a bottle experiment is essential to achieving a subsecond precision measurement of τn. We will present the preliminary results from the 2015-2016 data set and an update on the UCN τ experiment.

  17. Monsoon '90 - Preliminary SAR results

    NASA Technical Reports Server (NTRS)

    Dubois, Pascale C.; Van Zyl, Jakob J.; Guerra, Abel G.

    1992-01-01

    Multifrequency polarimetric synthetic aperture radar (SAR) images of the Walnut Gulch watershed near Tombstone, Arizona were acquired on 28 Mar. 1990 and on 1 Aug. 1990. Trihedral corner reflectors were deployed prior to both overflights to allow calibration of the two SAR data sets. During both overflights, gravimetric soil moisture and dielectric constant measurements were made. Detailed vegetation height, density, and water content measurements were made as part of the Monsoon 1990 Experiment. Preliminary results based on analysis of the multitemporal polarimetric SAR data are presented. Only the C-band data (5.7-cm wavelength) radar images show significant difference between Mar. and Aug., with the strongest difference observed in the HV images. Based on the radar data analysis and the in situ measurements, we conclude that these differences are mainly due to changes in the vegetation and not due to the soil moisture changes.

  18. Monsoon 1990: Preliminary SAR results

    NASA Technical Reports Server (NTRS)

    Vanzyl, Jakob J.; Dubois, Pascale; Guerra, Abel

    1991-01-01

    Multifrequency polarimetric synthetic aperture radar (SAR) images of the Walnut Gulch watershed near Tombstone, Arizona were acquired on 28 Mar. 1990 and on 1 Aug. 1990. Trihedral corner reflectors were deployed prior to both overflights to allow calibration of the two SAR data sets. During both overflights, gravimetric soil moisture and dielectric constant measurements were made. Detailed vegetation height, density, and water content measurements were made as part of the Monsoon 1990 Experiment. Preliminary results based on analysis of the multitemporal polarimetric SAR data are presented. Only the C-band data (5.7-cm wavelength) radar images show significant difference between Mar. and Aug., with the strongest difference observed in the HV images. Based on the radar data analysis and the in situ measurements, we conclude that these differences are mainly due to changes in the vegetation and not due to the soil moisture changes.

  19. Preliminary hazards analysis -- vitrification process

    SciTech Connect

    Coordes, D.; Ruggieri, M.; Russell, J.; TenBrook, W.; Yimbo, P.

    1994-06-01

    This paper presents a Preliminary Hazards Analysis (PHA) for mixed waste vitrification by joule heating. The purpose of performing a PHA is to establish an initial hazard categorization for a DOE nuclear facility and to identify those processes and structures which may have an impact on or be important to safety. The PHA is typically performed during and provides input to project conceptual design. The PHA is then followed by a Preliminary Safety Analysis Report (PSAR) performed during Title 1 and 2 design. The PSAR then leads to performance of the Final Safety Analysis Report performed during the facility`s construction and testing. It should be completed before routine operation of the facility commences. This PHA addresses the first four chapters of the safety analysis process, in accordance with the requirements of DOE Safety Guidelines in SG 830.110. The hazards associated with vitrification processes are evaluated using standard safety analysis methods which include: identification of credible potential hazardous energy sources; identification of preventative features of the facility or system; identification of mitigative features; and analyses of credible hazards. Maximal facility inventories of radioactive and hazardous materials are postulated to evaluate worst case accident consequences. These inventories were based on DOE-STD-1027-92 guidance and the surrogate waste streams defined by Mayberry, et al. Radiological assessments indicate that a facility, depending on the radioactive material inventory, may be an exempt, Category 3, or Category 2 facility. The calculated impacts would result in no significant impact to offsite personnel or the environment. Hazardous materials assessment indicates that a Mixed Waste Vitrification facility will be a Low Hazard facility having minimal impacts to offsite personnel and the environment.

  20. Stardust interstellar preliminary examination (ISPE).

    SciTech Connect

    Westphal, A.J.; Allen, C.; Bajt, S.; Basset, R.; Flynn, G.L.; Sutton, S.

    2009-03-23

    The Stardust Interstellar Preliminary Examination (ISPE) is a three-year effort to characterize the Stardust interstellar dust collection and collector using non-destructive techniques. We summarize the status of the ISPE. In January 2006 the Stardust sample return capsule returned to Earth bearing the first solid samples from a primitive solar system body, Comet 81P/Wild2, and a collector dedicated to the capture and return of contemporary interstellar dust. Both collectors were {approx}0.1 m{sup 2} in area and were composed of aerogel tiles (85% of the collecting area) and aluminum foils. The Stardust Interstellar Dust Collector (SIDC) was exposed to the interstellar dust stream for a total exposure factor of 20 m{sup 2}-day during two periods before the cometary encounter. The Stardust Interstellar Preliminary Examination (ISPE) is a three-year effort to characterize the collection using nondestructive techniques. The goals and restrictions of the ISPE are described in Westphal et al. The ISPE consists of six interdependent projects: (1) Candidate identification through automated digital microscopy and a massively distributed, calibrated search; (2) Candidate extraction and photodocumentation; (3) Characterization of candidates through synchrotron-based Fourier-Tranform Infrared Spectroscopy (FTIR), Scanning X-Ray Fluoresence Microscopy (SXRF), and Scanning Transmission X-ray Microscopy (STXM); (4) Search for and analysis of craters in foils through FESEM scanning, Auger Spectroscopy and synchrotron-based Photoemission Electron Microscopy (PEEM); (5) Modeling of interstellar dust transport in the solar system; and (6) Laboratory simulations of hypervelocity dust impacts into the collecting media.

  1. Preliminary design of JEM ECLSS and TCS

    NASA Astrophysics Data System (ADS)

    Suzuki, T.; Otsuki, F.; Suzuki, K.; Shibutani, S.; Hattori, A.; Sasayama, H.; Inoue, M.; Sugai, W.

    1991-12-01

    Preliminary design of the Japanese Module (JEM), which will be attached to the U.S. Space Station Freedom (SSF), began in early 1991. The target of the design activities is the Preliminary Design Review (PDR) planned in the beginning of 1992. The pressurized module of the JEM is composed of several subsystems including the Environmental Control and Life Support System (ECLSS), the Thermal Control System (TCS), mechanical equipment (airlock), the data management system, the communications and tracking system, the electrical power system, and the experiment support system. The preliminary design of ECLSS and TCS including the baseline configurations and the design requirements are described.

  2. Space station preliminary design report

    NASA Technical Reports Server (NTRS)

    1982-01-01

    The results of a 3 month preliminary design and analysis effort is presented. The configuration that emerged consists of a very stiff deployable truss structure with an overall triangular cross section having universal modules attached at the apexes. Sufficient analysis was performed to show feasibility of the configuration. An evaluation of the structure shows that desirable attributes of the configuration are: (1) the solar cells, radiators, and antennas will be mounted to stiff structure to minimize control problems during orbit maintenance and correction, docking, and attitude control; (2) large flat areas are available for mounting and servicing of equipment; (3) Large mass items can be mounted near the center of gravity of the system to minimize gravity gradient torques; (4) the trusses are lightweight structures and can be transported into orbit in one Shuttle flight; (5) the trusses are expandable and will require a minimum of EVA; and (6) the modules are anticipated to be structurally identical except for internal equipment to minimize cost.

  3. Advanced space engine preliminary design

    NASA Technical Reports Server (NTRS)

    Cuffe, J. P. B.; Bradie, R. E.

    1973-01-01

    A preliminary design was completed for an O2/H2, 89 kN (20,000 lb) thrust staged combustion rocket engine that has a single-bell nozzle with an overall expansion ratio of 400:1. The engine has a best estimate vacuum specific impulse of 4623.8 N-s/kg (471.5 sec) at full thrust and mixture ratio = 6.0. The engine employs gear-driven, low pressure pumps to provide low NPSH capability while individual turbine-driven, high-speed main pumps provide the system pressures required for high-chamber pressure operation. The engine design dry weight for the fixed-nozzle configuration is 206.9 kg (456.3 lb). Engine overall length is 234 cm (92.1 in.). The extendible nozzle version has a stowed length of 141.5 cm (55.7 in.). Critical technology items in the development of the engine were defined. Development program plans and their costs for development, production, operation, and flight support of the ASE were established for minimum cost and minimum time programs.

  4. Stardust Interstellar Preliminary Examination (ISPE)

    NASA Technical Reports Server (NTRS)

    Westphal, A. J.; Allen, C.; Bajt, S.; Basset, R.; Bastien, R.; Bechtel, H.; Bleuet, P.; Borg, J.; Brenker F.; Bridges, J.

    2009-01-01

    In January 2006 the Stardust sample return capsule returned to Earth bearing the first solid samples from a primitive solar system body, C omet 81P/Wild2, and a collector dedicated to the capture and return o f contemporary interstellar dust. Both collectors were approximately 0.1m(exp 2) in area and were composed of aerogel tiles (85% of the co llecting area) and aluminum foils. The Stardust Interstellar Dust Col lector (SIDC) was exposed to the interstellar dust stream for a total exposure factor of 20 m(exp 2-) day during two periods before the co metary encounter. The Stardust Interstellar Preliminary Examination ( ISPE) is a three-year effort to characterize the collection using no ndestructive techniques. The ISPE consists of six interdependent proj ects: (1) Candidate identification through automated digital microsco py and a massively distributed, calibrated search (2) Candidate extr action and photodocumentation (3) Characterization of candidates thro ugh synchrotronbased FourierTranform Infrared Spectroscopy (FTIR), S canning XRay Fluoresence Microscopy (SXRF), and Scanning Transmission Xray Microscopy (STXM) (4) Search for and analysis of craters in f oils through FESEM scanning, Auger Spectroscopy and synchrotronbased Photoemission Electron Microscopy (PEEM) (5) Modeling of interstell ar dust transport in the solar system (6) Laboratory simulations of h ypervelocity dust impacts into the collecting media

  5. EUPORIAS: plans and preliminary results

    NASA Astrophysics Data System (ADS)

    Buontempo, C.

    2013-12-01

    Recent advances in our understanding and ability to forecast climate variability have meant that skilful predictions are beginning to be routinely made on seasonal to decadal (s2d) timescales. Such forecasts have the potential to be of great value to a wide range of decision-making, where outcomes are strongly influenced by variations in the climate. In 2012 the European Commission funded EUPORIAS, a four year long project to develop prototype end-to-end climate impact prediction services operating on a seasonal to decadal timescale, and assess their value in informing decision-making. EUPORIAS commenced on 1 November 2012, coordinated by the UK Met Office leading a consortium of 24 organisations representing world-class European climate research and climate service centres, expertise in impacts assessments and seasonal predictions, two United Nations agencies, specialists in new media, and commercial companies in climate-vulnerable sectors such as energy, water and tourism. The poster describes the setup of the project, its main outcome and some of the very preliminary results.

  6. Preliminary Iron Distribution on Vesta

    NASA Technical Reports Server (NTRS)

    Mittlefehldt, David W.; Mittlefehldt, David W.

    2013-01-01

    The distribution of iron on the surface of the asteroid Vesta was investigated using Dawn's Gamma Ray and Neutron Detector (GRaND) [1,2]. Iron varies predictably with rock type for the howardite, eucrite, and diogenite (HED) meteorites, thought to be representative of Vesta. The abundance of Fe in howardites ranges from about 12 to 15 wt.%. Basaltic eucrites have the highest abundance, whereas, lower crustal and upper mantle materials (cumulate eucrites and diogenites) have the lowest, and howardites are intermediate [3]. We have completed a mapping study of 7.6 MeV gamma rays produced by neutron capture by Fe as measured by the bismuth germanate (BGO) detector of GRaND [1]. The procedures to determine Fe counting rates are presented in detail here, along with a preliminary distribution map, constituting the necessary initial step to quantification of Fe abundances. We find that the global distribution of Fe counting rates is generally consistent with independent mineralogical and compositional inferences obtained by other instruments on Dawn such as measurements of pyroxene absorption bands by the Visual and Infrared Spectrometer (VIR) [4] and Framing Camera (FC) [5] and neutron absorption measurements by GRaND [6].

  7. Preliminary Response Analysis of AUV

    NASA Astrophysics Data System (ADS)

    Hariri, Azian; Basharie, Siti Mariam; Ghani, Mohamad Hanifah Abd.

    2010-06-01

    Development of Autonomous Unmanned Vehicle (AUV) involves a great task to fully understand the overall working principles of an UAV that needed time, experience and a wide range of intelligence to cover the entire scientific facts. This study is done by means to acquire the fundamental knowledge in understanding the stability and response of an UAV. The longitudinal response and stability of UAV owing to deflection of stern plane during trimmed equilibrium motion can be computed by solving the AUV equation of motion. In this study, the AUV equations of motion were rederived and the solution was computed with the aid of Matlab software. From the existing AUV, a new dimension, weight and speed were specified to be used in the rederivation of the linearised AUV longitudinal equations of motion. From the analysis done, the longitudinal response AUV shows the stern plane and thrust has relatively steady longitudinal control power and quick response characteristic. The results had successfully given a preliminary insight of the specified AUV response and dynamic stability.

  8. Preliminary results of ANAIS-25

    NASA Astrophysics Data System (ADS)

    Amaré, J.; Cebrián, S.; Cuesta, C.; García, E.; Ginestra, C.; Martínez, M.; Oliván, M. A.; Ortigoza, Y.; Ortiz de Solórzano, A.; Pobes, C.; Puimedón, J.; Sarsa, M. L.; Villar, J. A.; Villar, P.

    2014-04-01

    The ANAIS (Annual Modulation with NaI(Tl) Scintillators) experiment aims at the confirmation of the DAMA/LIBRA signal using the same target and technique at the Canfranc Underground Laboratory. 250 kg of ultrapure NaI(Tl) crystals will be used as a target, divided into 20 modules, each coupled to two photomultipliers. Two NaI(Tl) crystals of 12.5 kg each, grown by Alpha Spectra from a powder having a potassium level under the limit of our analytical techniques, form the ANAIS-25 set-up. The background contributions are being carefully studied and preliminary results are presented: their natural potassium content in the bulk has been quantified, as well as the uranium and thorium radioactive chains presence in the bulk through the discrimination of the corresponding alpha events by PSA, and due to the fast commissioning, the contribution from cosmogenic activated isotopes is clearly identified and their decay observed along the first months of data taking. Following the procedures established with ANAIS-0 and previous prototypes, bulk NaI(Tl) scintillation events selection and light collection efficiency have been also studied in ANAIS-25.

  9. San Mateo Creek Basin Preliminary Assessment

    EPA Pesticide Factsheets

    The objective of this Preliminary Assessment is to evaluate the site using the Hazard Ranking System and the Superfund Chemical Data Matrix to determine if a threat to human health and the environment exists such that further action is warranted.

  10. 40 CFR 158.345 - Preliminary analysis.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... REQUIREMENTS FOR PESTICIDES Product Chemistry § 158.345 Preliminary analysis. (a) If the product is produced by... point in the production process after which no further chemical reactions designed to produce or...

  11. Multidisciplinary Optimization Methods for Preliminary Design

    NASA Technical Reports Server (NTRS)

    Korte, J. J.; Weston, R. P.; Zang, T. A.

    1997-01-01

    An overview of multidisciplinary optimization (MDO) methodology and two applications of this methodology to the preliminary design phase are presented. These applications are being undertaken to improve, develop, validate and demonstrate MDO methods. Each is presented to illustrate different aspects of this methodology. The first application is an MDO preliminary design problem for defining the geometry and structure of an aerospike nozzle of a linear aerospike rocket engine. The second application demonstrates the use of the Framework for Interdisciplinary Design Optimization (FIDO), which is a computational environment system, by solving a preliminary design problem for a High-Speed Civil Transport (HSCT). The two sample problems illustrate the advantages to performing preliminary design with an MDO process.

  12. 29 CFR 1955.31 - Preliminary conference.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) PROCEDURES FOR WITHDRAWAL OF APPROVAL OF STATE PLANS Preliminary Conference and Discovery § 1955... those not disposed of by admissions or agreements, and control the subsequent course of the...

  13. 43 CFR 3425.1-7 - Preliminary data.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Preliminary data. 3425.1-7 Section 3425.1... Preliminary data. (a) Any application for a lease shall contain preliminary data to assist the authorized... preliminary data shall include: (1) A map, or maps, showing the topography, physical features and...

  14. AGR-1 Irradiated Test Train Preliminary Inspection and Disassembly First Look

    SciTech Connect

    Paul Demkowicz; Lance Cole; Scott Ploger; Philip Winston; Binh Pham; Michael Abbott

    2011-01-01

    The AGR-1 irradiation experiment ended on November 6, 2009, after 620 effective full power days in the Advanced Test Reactor, achieving a peak burnup of 19.6% FIMA. The test train was shipped to the Materials and Fuels Complex in March 2010 for post-irradiation examination. The first PIE activities included non-destructive examination of the test train, followed by disassembly of the test train and individual capsules and detailed inspection of the capsule contents, including the fuel compacts and the graphite fuel holders. Dimensional measurements of the compacts, graphite holders, and steel capsules shells were performed using a custom vision measurement system (for outer diameters and lengths) and conventional bore gauges (for inner diameters). Gamma spectrometry of the intact test train gave a preliminary look at the condition of the interior components. No evidence of damage to compacts or graphite components was evident from the isotopic and gross gamma scans. Neutron radiography of the intact Capsule 2 showed a high degree of detail of interior components and confirmed the observation that there was no major damage to the capsule. Disassembly of the capsules was initiated using procedures qualified during out-of-cell mockup testing. Difficulties were encountered during capsule disassembly due to irradiation-induced changes in some of the capsule components’ properties, including embrittled niobium and molybdenum parts that were susceptible to fracture and swelling of the graphite fuel holders that affected their removal from the capsule shells. This required various improvised modifications to the disassembly procedure to avoid damage to the fuel compacts. Ultimately the capsule disassembly was successful and only one compact from Capsule 4 (out of 72 total in the test train) sustained damage during the disassembly process, along with the associated graphite holder. The compacts were generally in very good condition upon removal. Only relatively minor

  15. [Features of the distribution of BoLA-A antigens and alleles of the BoLA-DRB3 gene in Black Pied cattle in relation to association with leukemia].

    PubMed

    Ernst, L K; Sulimova, G E; Orlova, A R; Udina, I G; Pavlenko, S P

    1997-01-01

    The character of distribution of BoLA class-I antigens was studied in Black Pied cattle populations differing in status in relation to leukemia. Associative relationships of distinct antigens with resistance and susceptibility to leukemia were revealed. Using the statusmetria method, an integral estimate of predisposition to leukemia (Z) was calculated taking into consideration the contribution of each antigen in the immunogenetic status of the animal. The interval of Z values was determined, which allowed animals to be divided into groups according to resistance or susceptibility to leukemia. Alleles of the BoLA-DRB3 gene were typed in subsamples of animals with leukemia and healthy animals by the PCR-RFLP method. Twenty alleles of the gene were detected, and their frequencies were determined in both subsamples. Alleles mediating resistance of animals to leukemia (BoLA-DRB3.2*11, *23, and *28) were distributed in the group of healthy animals with frequencies of 0.079, 0.132, and 0.053, respectively; they were completely absent in animals with leukemia. The data on the estimate of animal status in relation to leukemia, which were obtained by the method of statusmetria taking in consideration the real contribution of the each class-I antigen in the detection of the disease risk (value Z), and data of allele typing by the PCR-RFLP method were shown to be in good agreement. The possibility of using BoLA class-I antigen typing in herds to determine the number of animals with leukemia was demonstrated.

  16. Preliminary Results from the iMUSH Active Source Seismic Experiment

    NASA Astrophysics Data System (ADS)

    Levander, Alan; Kiser, Eric; Palomeras, Imma; Zelt, Colin; Schmandt, Brandon; Hansen, Steve; Harder, Steven; Creagar, Kenneth; Vidale, John; Abers, Geoffrey

    2015-04-01

    iMUSH (imaging Magma Under Saint Helens) is a US NSF sponsored multi-disciplinary investigation of Mount Saint Helens (MSH), currently the most active volcano in the Cascades arc in the northwestern United States. The project consists of active and passive seismic experiments, extensive magnetotelluric sounding, and geological/geochemical studies involving scientists at 7 institutions in the U.S. and Europe. The long-term goal of the seismic project is to combine analysis of the active source data with that of data from the 70 element broadband seismograph operating from summer 2014 until 2016. Combining seismic and MT analyses with other data, we hope to image the MSH volcanic plumbing system from the surface to the subducting Juan de Fuca slab. Here we describe preliminary results of the iMUSH active source seismic experiment, conducted in July and August 2014. The active source experiment consisted of twenty-three 454 or 908 kg weight shots recorded by ~3500 seismographs deployed at ~6,000 locations. Of these instruments, ~900 Nodal Seismic instruments were deployed continuously for two weeks in an areal array within 10 km of the MSH summit. 2,500 PASSCAL Texan instruments were deployed twice for five days in 3 areal arrays and 2 dense orthogonal linear arrays that extended from MSH to distances > 80 km. Overall the data quality from the shots is excellent. The seismograph arrays also recorded dozens of micro-earthquakes beneath the MSH summit and along the MSH seismic zone, and numerous other local and regional earthquakes. In addition, at least one low frequency event beneath MSH was recorded during the experiment. At this point we have begun various types of analysis of the data set: We have determined an average 1D Vp structure from stacking short-term/long-term average ratios, we have determined the 2-D Vp structure from ray-trace inversions along the two orthogonal profiles (in the NW-SE and NE-SW directions), and we have made low-fold CMP stacks of the

  17. Preliminary LISA Telescope Spacer Design

    NASA Technical Reports Server (NTRS)

    Livas, J.; Arsenovic, P.; Catellucci, K.; Generie, J.; Howard, J.; Stebbins, R. T.

    2010-01-01

    The Laser Interferometric Space Antenna (LISA) mission observes gravitational waves by measuring the separations between freely floating proof masses located 5 million kilometers apart with an accuracy of approximately 10 picometers. The separations are measured interferometrically. The telescope is an afocal Cassegrain style design with a magnification of 80x. The entrance pupil has a 40 cm diameter and will either be centered on-axis or de-centered off-axis to avoid obscurations. Its two main purposes are to transform the small diameter beam used on the optical bench to a diffraction limited collimated beam to efficiently transfer the metrology laser between spacecraft, and to receive the incoming light from the far spacecraft. It transmits and receives simultaneously. The basic optical design and requirements are well understood for a conventional telescope design for imaging applications, but the LISA design is complicated by the additional requirement that the total optical path through the telescope must remain stable at the picometer level over the measurement band during the mission to meet the measurement accuracy. This poster describes the requirements for the telescope and the preliminary work that has been done to understand the materials and mechanical issues associated with the design of a passive metering structure to support the telescope and to maintain the spacing between the primary and secondary mirrors in the LISA on-orbit environment. This includes the requirements flowdown from the science goals, thermal modeling of the spacecraft and telescope to determine the expected temperature distribution,layout options for the telescope including an on- and off-axis design, and plans for fabrication and testing.

  18. ERIS: preliminary design phase overview

    NASA Astrophysics Data System (ADS)

    Kuntschner, Harald; Jochum, Lieselotte; Amico, Paola; Dekker, Johannes K.; Kerber, Florian; Marchetti, Enrico; Accardo, Matteo; Brast, Roland; Brinkmann, Martin; Conzelmann, Ralf D.; Delabre, Bernard A.; Duchateau, Michel; Fedrigo, Enrico; Finger, Gert; Frank, Christoph; Rodriguez, Fernando G.; Klein, Barbara; Knudstrup, Jens; Le Louarn, Miska; Lundin, Lars; Modigliani, Andrea; Müller, Michael; Neeser, Mark; Tordo, Sebastien; Valenti, Elena; Eisenhauer, Frank; Sturm, Eckhard; Feuchtgruber, Helmut; George, Elisabeth M.; Hartl, Michael; Hofmann, Reiner; Huber, Heinrich; Plattner, Markus P.; Schubert, Josef; Tarantik, Karl; Wiezorrek, Erich; Meyer, Michael R.; Quanz, Sascha P.; Glauser, Adrian M.; Weisz, Harald; Esposito, Simone; Xompero, Marco; Agapito, Guido; Antichi, Jacopo; Biliotti, Valdemaro; Bonaglia, Marco; Briguglio, Runa; Carbonaro, Luca; Cresci, Giovanni; Fini, Luca; Pinna, Enrico; Puglisi, Alfio T.; Quirós-Pacheco, Fernando; Riccardi, Armando; Di Rico, Gianluca; Arcidiacono, Carmelo; Dolci, Mauro

    2014-07-01

    The Enhanced Resolution Imager and Spectrograph (ERIS) is the next-generation adaptive optics near-IR imager and spectrograph for the Cassegrain focus of the Very Large Telescope (VLT) Unit Telescope 4, which will soon make full use of the Adaptive Optics Facility (AOF). It is a high-Strehl AO-assisted instrument that will use the Deformable Secondary Mirror (DSM) and the new Laser Guide Star Facility (4LGSF). The project has been approved for construction and has entered its preliminary design phase. ERIS will be constructed in a collaboration including the Max- Planck Institut für Extraterrestrische Physik, the Eidgenössische Technische Hochschule Zürich and the Osservatorio Astrofisico di Arcetri and will offer 1 - 5 μm imaging and 1 - 2.5 μm integral field spectroscopic capabilities with a high Strehl performance. Wavefront sensing can be carried out with an optical high-order NGS Pyramid wavefront sensor, or with a single laser in either an optical low-order NGS mode, or with a near-IR low-order mode sensor. Due to its highly sensitive visible wavefront sensor, and separate near-IR low-order mode, ERIS provides a large sky coverage with its 1' patrol field radius that can even include AO stars embedded in dust-enshrouded environments. As such it will replace, with a much improved single conjugated AO correction, the most scientifically important imaging modes offered by NACO (diffraction limited imaging in the J to M bands, Sparse Aperture Masking and Apodizing Phase Plate (APP) coronagraphy) and the integral field spectroscopy modes of SINFONI, whose instrumental module, SPIFFI, will be upgraded and re-used in ERIS. As part of the SPIFFI upgrade a new higher resolution grating and a science detector replacement are envisaged, as well as PLC driven motors. To accommodate ERIS at the Cassegrain focus, an extension of the telescope back focal length is required, with modifications of the guider arm assembly. In this paper we report on the status of the

  19. Very preliminary reference Moon model

    NASA Astrophysics Data System (ADS)

    Garcia, Raphaël F.; Gagnepain-Beyneix, Jeannine; Chevrot, Sébastien; Lognonné, Philippe

    2011-09-01

    The deep structure of the Moon is a missing piece to understand the formation and evolution of the Earth-Moon system. Despite the great amount of information brought by the Apollo passive seismic experiment (ALSEP), the lunar structure below deep moonquakes, which occur around 900 km depth, remains largely unknown. We construct a reference Moon model which incorporates physical constraints, and fits both geodesic (lunar mass and polar moment of inertia, and Love numbers) and seismological (body wave arrivals measured by Apollo network) data. In this model, the core radius is constrained by the detection of S waves reflected from the core. In a first step, for each core radius, a radial model of the lunar interior, including P and S wave velocities and density, is inverted from seismic and geodesic data. In a second step, the core radius is determined from the detection of shear waves reflected on the lunar core by waveform stacking of deep moonquake Apollo records. This detection has been made possible by careful data selection and processing, including a correction of the gain of horizontal sensors based on the principle of energy equipartition inside the coda of lunar seismic records, and a precise alignment of SH waveforms by a non-linear inversion method. The Very Preliminary REference MOON model (VPREMOON) obtained here has a core radius of 380 ± 40 km and an average core mass density of 5200 ± 1000 kg/m 3. The large error bars on these estimates are due to the poorly constrained S-wave velocity profile at the base of the mantle and to mislocation errors of deep moonquakes. The detection of horizontally polarized S waves reflected from the core and the absence of detection of vertically polarized S waves favour a liquid state in the outermost part of the core. All these results are consistent, within their error bars, with previous estimates based on lunar rotation dissipation ( Williams et al., 2001) and on lunar induced magnetic moment ( Hood et al., 1999).

  20. Hydrothermal Liquefaction Treatment Preliminary Hazard Analysis Report

    SciTech Connect

    Lowry, Peter P.; Wagner, Katie A.

    2015-08-31

    A preliminary hazard assessment was completed during February 2015 to evaluate the conceptual design of the modular hydrothermal liquefaction treatment system. The hazard assessment was performed in 2 stages. An initial assessment utilizing Hazard Identification and Preliminary Hazards Analysis (PHA) techniques identified areas with significant or unique hazards (process safety-related hazards) that fall outside of the normal operating envelope of PNNL and warranted additional analysis. The subsequent assessment was based on a qualitative What-If analysis. This analysis was augmented, as necessary, by additional quantitative analysis for scenarios involving a release of hazardous material or energy with the potential for affecting the public.

  1. Preliminary designs: passive solar manufactured housing. Technical status report

    SciTech Connect

    Not Available

    1980-05-12

    The criteria established to guide the development of the preliminary designs are listed. Three preliminary designs incorporating direct gain and/or sunspace are presented. Costs, drawings, and supporting calculations are included. (MHR)

  2. 37 CFR 1.484 - Conduct of international preliminary examination.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... international preliminary examination will be conducted on inventions not previously searched by an International Searching Authority. (d) The International Preliminary Examining Authority will establish a... reply. (e) The written opinion established by the International Searching Authority under PCT Rule...

  3. 37 CFR 1.484 - Conduct of international preliminary examination.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... international preliminary examination will be conducted on inventions not previously searched by an International Searching Authority. (d) The International Preliminary Examining Authority will establish a... reply. (e) The written opinion established by the International Searching Authority under PCT Rule...

  4. Preliminary Results of an On-Line, Multi-Spectrometer Fission Product Monitoring System to Support Advanced Gas Reactor Fuel Testing and Qualification in the Advanced Test Reactor at the Idaho National Laboratory

    SciTech Connect

    Dawn M. Scates; John K. Hartwell; John B. Walter; Mark W. Drigert

    2007-10-01

    The Advanced Gas Reactor -1 (AGR-1) experiment is the first experiment in a series of eight separate low enriched uranium (LEU) oxycarbide (UCO) tri-isotropic (TRISO) particle fuel (in compact form) experiments scheduled for placement in the Advanced Test Reactor (ATR) located at the Idaho National Laboratory (INL). The experiment began irradiation in the ATR with a cycle that reached full power on December 26, 2006 and will continue irradiation for about 2.5 years. During this time six separate capsules, will be irradiated in an inert sweep gas atmosphere with individual on-line fission product monitoring on its effluent to track performance of the fuel in each individual capsule during irradiation. The goals of the irradiation experiment is to provide irradiation performance data to support fuel process development, to qualify fuel for normal operating conditions, to support development and validation of fuel, and to provide irradiated fuel and materials for post irradiation examination (PIE) and safety testing. This paper presents the preliminary test details of the fuel performance, as measured by the control and acquisition software.

  5. Polarized electrons in ELSA (preliminary results)

    NASA Astrophysics Data System (ADS)

    Nakamura, S.; von Drachenfels, W.; Durek, D.; Frommberger, F.; Hoffmann, M.; Husmann, D.; Kiel, B.; Klein, F. J.; Menze, D.; Michel, T.; Nakanishi, T.; Naumann, J.; Reichelt, T.; Steier, C.; Toyama, T.; Voigt, S.; Westermann, M.

    1998-01-01

    Polarized electrons have been accelerated in the electron stretcher accelerator ELSA for the first time. Up to 2.1 GeV the polarization of the electron beam supplied by the 120 keV polarized electron source has been measured with a Mo/ller polarimeter. Preliminary results of polarization measurements at high energies and the performance of the source are presented.

  6. 32 CFR 1900.11 - Preliminary Information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... TO CIA RECORDS UNDER THE FREEDOM OF INFORMATION ACT (FOIA) Filing of Foia Requests § 1900.11 Preliminary Information. Members of the public shall address all communications to the CIA Coordinator as... Information Act and this regulation. CIA employees receiving a communication in the nature of a FOIA...

  7. 28 CFR 36.604 - Preliminary determination.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Preliminary determination. 36.604 Section 36.604 Judicial Administration DEPARTMENT OF JUSTICE NONDISCRIMINATION ON THE BASIS OF DISABILITY BY PUBLIC ACCOMMODATIONS AND IN COMMERCIAL FACILITIES Certification of State Laws or Local Building...

  8. Preliminary Findings on Rural Homelessness in Ohio.

    ERIC Educational Resources Information Center

    First, Richard J.; And Others

    This report is designed to present preliminary findings from the first comprehensive study of rural homelessness in the United States. The study was conducted during the first 6 months of 1990, and data were collected from interviews with 921 homeless adults in 21 randomly selected rural counties in Ohio. The sample counties represent 26% of the…

  9. Secondary School Mathematics. Preliminary Version. Sample Chapters.

    ERIC Educational Resources Information Center

    Bell, Max S.; And Others

    This volume contains preliminary versions of five of the chapters prepared by the SMSG curriculum project for use in grades 7 and 8. The first four chapters and the tenth chapter in the sequence are presented. The sample chapters in this volume illustrate a number of aspects of the curriculum project: (1) association of ideas of number and space…

  10. National Mathematics Advisory Panel Preliminary Report

    ERIC Educational Resources Information Center

    US Department of Education, 2007

    2007-01-01

    The National Mathematics Advisory Panel was established within the Department of Education as part of the President's "American Competitiveness Initiative" through Executive Order 13398, April 18, 2006. This document fulfills the obligation of that order to issue a Preliminary Report no later than January 31, 2007. The Panel chose to divide into…

  11. A Preliminary "Basic Math Program" Proposal.

    ERIC Educational Resources Information Center

    Luhring, Richard

    This report proposes a preliminary basic math program that may help mitigate the student attrition problem at Contra Costa College (California). For the purposes of this proposal, Math 101, 115, and 118 are identified as courses to be included in the program. The essential features of this proposed curriculum are summarized as follows: (1) it…

  12. 32 CFR 1700.4 - Preliminary information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... receive a FOIA request shall expeditiously forward the request to the Director, Information Management... 32 National Defense 6 2013-07-01 2013-07-01 false Preliminary information. 1700.4 Section 1700.4... INTELLIGENCE PROCEDURES FOR DISCLOSURE OF RECORDS PURSUANT TO THE FREEDOM OF INFORMATION ACT §...

  13. 32 CFR 1700.4 - Preliminary information.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... receive a FOIA request shall expeditiously forward the request to the Director, Information Management... 32 National Defense 6 2014-07-01 2014-07-01 false Preliminary information. 1700.4 Section 1700.4... INTELLIGENCE PROCEDURES FOR DISCLOSURE OF RECORDS PURSUANT TO THE FREEDOM OF INFORMATION ACT §...

  14. 32 CFR 1700.4 - Preliminary information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... receive a FOIA request shall expeditiously forward the request to the Director, Information Management... 32 National Defense 6 2010-07-01 2010-07-01 false Preliminary information. 1700.4 Section 1700.4... INTELLIGENCE PROCEDURES FOR DISCLOSURE OF RECORDS PURSUANT TO THE FREEDOM OF INFORMATION ACT §...

  15. 32 CFR 1700.4 - Preliminary information.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... receive a FOIA request shall expeditiously forward the request to the Director, Information Management... 32 National Defense 6 2012-07-01 2012-07-01 false Preliminary information. 1700.4 Section 1700.4... INTELLIGENCE PROCEDURES FOR DISCLOSURE OF RECORDS PURSUANT TO THE FREEDOM OF INFORMATION ACT §...

  16. 32 CFR 1700.4 - Preliminary information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... receive a FOIA request shall expeditiously forward the request to the Director, Information Management... 32 National Defense 6 2011-07-01 2011-07-01 false Preliminary information. 1700.4 Section 1700.4... INTELLIGENCE PROCEDURES FOR DISCLOSURE OF RECORDS PURSUANT TO THE FREEDOM OF INFORMATION ACT §...

  17. 40 CFR 161.170 - Preliminary analysis.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Preliminary analysis. 161.170 Section 161.170 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES Product Chemistry Data Requirements §...

  18. 32 CFR 1800.11 - Preliminary information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Preliminary information. 1800.11 Section 1800.11 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER PUBLIC ACCESS TO NACIC RECORDS UNDER THE FREEDOM OF INFORMATION ACT (FOIA) Filing of FOIA Requests §...

  19. 32 CFR 1803.11 - Preliminary information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Preliminary information. 1803.11 Section 1803.11 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER PUBLIC REQUESTS FOR MANDATORY DECLASSIFICATION REVIEW OF CLASSIFIED INFORMATION PURSUANT TO SECTION 3.6...

  20. 32 CFR 1800.11 - Preliminary information.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false Preliminary information. 1800.11 Section 1800.11 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER PUBLIC ACCESS TO NACIC RECORDS UNDER THE FREEDOM OF INFORMATION ACT (FOIA) Filing of FOIA Requests §...

  1. 32 CFR 1803.11 - Preliminary information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Preliminary information. 1803.11 Section 1803.11 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER PUBLIC REQUESTS FOR MANDATORY DECLASSIFICATION REVIEW OF CLASSIFIED INFORMATION PURSUANT TO SECTION 3.6...

  2. 32 CFR 1800.11 - Preliminary information.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Preliminary information. 1800.11 Section 1800.11 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER PUBLIC ACCESS TO NACIC RECORDS UNDER THE FREEDOM OF INFORMATION ACT (FOIA) Filing of FOIA Requests §...

  3. 32 CFR 1800.11 - Preliminary information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Preliminary information. 1800.11 Section 1800.11 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER PUBLIC ACCESS TO NACIC RECORDS UNDER THE FREEDOM OF INFORMATION ACT (FOIA) Filing of FOIA Requests §...

  4. 32 CFR 1800.11 - Preliminary information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Preliminary information. 1800.11 Section 1800.11 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER PUBLIC ACCESS TO NACIC RECORDS UNDER THE FREEDOM OF INFORMATION ACT (FOIA) Filing of FOIA Requests §...

  5. A DESCRIPTIVE INDONESIAN GRAMMAR--PRELIMINARY EDITION.

    ERIC Educational Resources Information Center

    DYEN, ISIDORE

    THIS PRELIMINARY EDITION COMPRISES A DESCRIPTIVE GRAMMAR OF INDONESIAN (BAHASA INDONESIA), THE OFFICIAL LANGUAGE OF THE REPUBLIC OF INDONESIA. THE THREE SECTIONS--PHONOLOGY, SYNTAX, AND MORPHOLOGY--PRESENT A COMPREHENSIVE LINGUISTIC ANALYSIS OF INDONESIAN, WITH OCCASIONAL CONTRASTIVE REFERENCE TO MALAY, JAVANESE, SUNDANESE, AND SUMATRAN. THIS…

  6. 40 CFR 161.170 - Preliminary analysis.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Preliminary analysis. 161.170 Section 161.170 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES Product Chemistry Data Requirements §...

  7. Preliminary radiation shielding design for BOOMERANG

    SciTech Connect

    Donahue, Richard J.

    2002-10-23

    Preliminary radiation shielding specifications are presented here for the 3 GeV BOOMERANG Australian synchrotron light source project. At this time the bulk shield walls for the storage ring and injection system (100 MeV Linac and 3 GeV Booster) are considered for siting purposes.

  8. 25 CFR 11.1005 - Preliminary inquiry.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... detention or shelter care, the children's court shall conduct a preliminary inquiry within 24 hours for the... delinquent act; and (2) Whether continued detention or shelter care is necessary pending further proceedings...; and (2) The need for detention or shelter care. (f) If the children's court finds that probable...

  9. 25 CFR 11.1105 - Preliminary inquiry.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... shelter care, the children's court shall conduct a preliminary inquiry with 24 hours for the purpose of...) Whether continued shelter care is necessary pending further proceedings. (b) If a minor has been released... the complaint or the taking of the minor into custody; and (2) The need for shelter care. (f) If...

  10. Preliminary aerothermodynamic design method for hypersonic vehicles

    NASA Technical Reports Server (NTRS)

    Harloff, G. J.; Petrie, S. L.

    1987-01-01

    Preliminary design methods are presented for vehicle aerothermodynamics. Predictions are made for Shuttle orbiter, a Mach 6 transport vehicle and a high-speed missile configuration. Rapid and accurate methods are discussed for obtaining aerodynamic coefficients and heat transfer rates for laminar and turbulent flows for vehicles at high angles of attack and hypersonic Mach numbers.

  11. 10 CFR 71.85 - Preliminary determinations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Preliminary determinations. 71.85 Section 71.85 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PACKAGING AND TRANSPORTATION OF RADIOACTIVE MATERIAL Operating... shipment of licensed material— (a) The licensee shall ascertain that there are no cracks,...

  12. 19 CFR 207.108 - Preliminary conference.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 3 2013-04-01 2013-04-01 false Preliminary conference. 207.108 Section 207.108 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF WHETHER INJURY TO DOMESTIC INDUSTRIES RESULTS FROM IMPORTS SOLD AT LESS THAN FAIR VALUE OR...

  13. 19 CFR 207.108 - Preliminary conference.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Preliminary conference. 207.108 Section 207.108 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF WHETHER INJURY TO DOMESTIC INDUSTRIES RESULTS FROM IMPORTS SOLD AT LESS THAN FAIR VALUE OR...

  14. 19 CFR 207.108 - Preliminary conference.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 3 2014-04-01 2014-04-01 false Preliminary conference. 207.108 Section 207.108 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF WHETHER INJURY TO DOMESTIC INDUSTRIES RESULTS FROM IMPORTS SOLD AT LESS THAN FAIR VALUE OR...

  15. 19 CFR 207.108 - Preliminary conference.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Preliminary conference. 207.108 Section 207.108 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF WHETHER INJURY TO DOMESTIC INDUSTRIES RESULTS FROM IMPORTS SOLD AT LESS THAN FAIR VALUE OR...

  16. 19 CFR 207.108 - Preliminary conference.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 3 2012-04-01 2012-04-01 false Preliminary conference. 207.108 Section 207.108 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF WHETHER INJURY TO DOMESTIC INDUSTRIES RESULTS FROM IMPORTS SOLD AT LESS THAN FAIR VALUE OR...

  17. 40 CFR 161.170 - Preliminary analysis.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Preliminary analysis. 161.170 Section 161.170 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES Product Chemistry Data Requirements §...

  18. 40 CFR 161.170 - Preliminary analysis.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Preliminary analysis. 161.170 Section 161.170 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR REGISTRATION OF ANTIMICROBIAL PESTICIDES Product Chemistry Data Requirements §...

  19. Preliminary tests of the electrostatic plasma accelerator

    NASA Technical Reports Server (NTRS)

    Aston, G.; Acker, T.

    1990-01-01

    This report describes the results of a program to verify an electrostatic plasma acceleration concept and to identify those parameters most important in optimizing an Electrostatic Plasma Accelerator (EPA) thruster based upon this thrust mechanism. Preliminary performance measurements of thrust, specific impulse and efficiency were obtained using a unique plasma exhaust momentum probe. Reliable EPA thruster operation was achieved using one power supply.

  20. Preliminary Safety Analysis for the IRIS Reactor

    SciTech Connect

    Ricotti, M.E.; Cammi, A.; Cioncolini, A.; Lombardi, C.; Cipollaro, A.; Orioto, F.; Conway, L.E.; Barroso, A.C.

    2002-07-01

    A deterministic analysis of the IRIS safety features has been carried out by means of the best-estimate code RELAP (ver. RELAP5 mod3.2). First, the main system components were modeled and tested separately, namely: the Reactor Pressure Vessel (RPV), the modular helical-coil Steam Generators (SG) and the Passive (natural circulation) Emergency Heat Removal System (PEHRS). Then, a preliminary set of accident transients for the whole primary and safety systems was investigated. Since the project was in a conceptual phase, the reported analyses must be considered preliminary. In fact, neither the reactor components, nor the safety systems and the reactor signal logics were completely defined at that time. Three 'conventional' design basis accidents have been preliminary evaluated: a Loss Of primary Flow Accident, a Loss Of Coolant Accident and a Loss Of Feed Water accident. The results show the effectiveness of the safety systems also in LOCA conditions; the core remains covered for the required grace period. This provides the basis to move forward to the preliminary design. (authors)

  1. 32 CFR 651.49 - Preliminary phase.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 4 2014-07-01 2013-07-01 true Preliminary phase. 651.49 Section 651.49 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) ENVIRONMENTAL QUALITY ENVIRONMENTAL ANALYSIS OF ARMY ACTIONS (AR 200-2) Public Involvement and the Scoping Process §...

  2. 32 CFR 651.49 - Preliminary phase.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Preliminary phase. 651.49 Section 651.49 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) ENVIRONMENTAL QUALITY ENVIRONMENTAL ANALYSIS OF ARMY ACTIONS (AR 200-2) Public Involvement and the Scoping Process §...

  3. 32 CFR 651.49 - Preliminary phase.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 4 2013-07-01 2013-07-01 false Preliminary phase. 651.49 Section 651.49 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) ENVIRONMENTAL QUALITY ENVIRONMENTAL ANALYSIS OF ARMY ACTIONS (AR 200-2) Public Involvement and the Scoping Process §...

  4. 32 CFR 651.49 - Preliminary phase.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 4 2012-07-01 2011-07-01 true Preliminary phase. 651.49 Section 651.49 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) ENVIRONMENTAL QUALITY ENVIRONMENTAL ANALYSIS OF ARMY ACTIONS (AR 200-2) Public Involvement and the Scoping Process §...

  5. 18 CFR 154.105 - Preliminary statement.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Preliminary statement. 154.105 Section 154.105 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT RATE SCHEDULES AND TARIFFS Form and Composition...

  6. Engineering Technology Programs. Preliminary Curriculum Planning Guide.

    ERIC Educational Resources Information Center

    Center for Occupational Research and Development, Inc., Waco, TX.

    Developed as a resource to assist in a major revision underway in Georgia area technical schools to change curricula for preparing engineering technicians, this preliminary program-planning guide describes curriculum structures for specialized programs in three major areas--electronics, electromechanics, and mechanics. The handbook, which is…

  7. 32 CFR 1900.11 - Preliminary Information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... TO CIA RECORDS UNDER THE FREEDOM OF INFORMATION ACT (FOIA) Filing of Foia Requests § 1900.11 Preliminary Information. Members of the public shall address all communications to the CIA Coordinator as... Information Act and this regulation. CIA employees receiving a communication in the nature of a FOIA...

  8. 32 CFR 1900.11 - Preliminary Information.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... TO CIA RECORDS UNDER THE FREEDOM OF INFORMATION ACT (FOIA) Filing of Foia Requests § 1900.11 Preliminary Information. Members of the public shall address all communications to the CIA Coordinator as... Information Act and this regulation. CIA employees receiving a communication in the nature of a FOIA...

  9. 32 CFR 1900.11 - Preliminary Information.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... TO CIA RECORDS UNDER THE FREEDOM OF INFORMATION ACT (FOIA) Filing of Foia Requests § 1900.11 Preliminary Information. Members of the public shall address all communications to the CIA Coordinator as... Information Act and this regulation. CIA employees receiving a communication in the nature of a FOIA...

  10. 32 CFR 1900.11 - Preliminary Information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... TO CIA RECORDS UNDER THE FREEDOM OF INFORMATION ACT (FOIA) Filing of Foia Requests § 1900.11 Preliminary Information. Members of the public shall address all communications to the CIA Coordinator as... Information Act and this regulation. CIA employees receiving a communication in the nature of a FOIA...

  11. PIE: A Dynamic Failure-Based Technique

    NASA Technical Reports Server (NTRS)

    Voas, Jeffrey M.

    1990-01-01

    This paper presents a dynamic technique for statistically estimating three program characteristics that affect a program's computational behavior: (1) the probability that a particular section of a program is executed, (2) the probability that the particular section affects the data state, and (3) the probability that a data state produced by that section has an effect on program output. These three characteristics can be used to predict whether faults are likely to be uncovered by software testing. Index Terms: Software testing, data state, fault, failure, testability. 1 Introduction

  12. A pie in the face of greed.

    PubMed

    Baldwin, F D

    1994-01-01

    Though every physician has his or her own way of treating patients, Hunter D. "Patch" Adams, MD, has an approach all his own: He uses clowning to break the barriers of practicing medicine. In a recent Central Pennsylvania appearance, Dr. Adams discussed his approach, as well as the importance of compassion in medicine.

  13. Trash Pie: Is Your School Serving?

    ERIC Educational Resources Information Center

    Hoover, Krista M.; Curran, Mary Carla

    2010-01-01

    In observation of Earth Day, third-grade students were invited to examine what they contribute to the landfill and learn new ways they could help protect the environment. In this lesson, students collected, evaluated, and displayed data comparing the trash generated by home-lunch versus school-lunch students. Students interpreted their findings…

  14. Of stewardship, motherhood and apple pie.

    PubMed

    Livermore, David M

    2014-04-01

    Antibiotic stewardship is universally agreed to be desirable, but optimal models for stewardship remain uncertain. UK stewardship targets the particular antibiotic families-cephalosporins and fluoroquinolones-blamed for the selection of Clostridium-difficile-associated disease. To balance this there have been dramatic increases in the use of penicillin-β-lactamase inhibitor combinations. By channelling selection pressure in this way, we hazard destroying the utility of these antibiotic classes in turn, as happened with gonorrhoea where penicillins, fluoroquinolones and cefixime were sequentially lost as therapies. Strikingly, in context, almost all carbapenemase-producers are highly resistant to penicillin-β-lactamase inhibitor combinations, which may select for them. There is an urgent need to explore an alternative stewardship model, seeking to limit total antibiotic use but to maintain heterogeneity in what is used, avoiding concentrated selection pressure. There is also a great need to improve and accelerate diagnostics for infection and resistance, reducing or removing the need for protracted empirical treatment with broad-spectrum agents.

  15. 36 CFR 72.16 - Preliminary Action Program requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Preliminary Action Program... INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.16 Preliminary.... Included should be a brief discussion of the relationship of the Preliminary Action Program to...

  16. 36 CFR 72.16 - Preliminary Action Program requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Preliminary Action Program... INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.16 Preliminary.... Included should be a brief discussion of the relationship of the Preliminary Action Program to...

  17. 32 CFR 644.30 - Preliminary real estate work.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Preliminary real estate work. 644.30 Section 644... PROPERTY REAL ESTATE HANDBOOK Project Planning Military (army and Air Force) and Other Federal Agencies § 644.30 Preliminary real estate work. (a) Preliminary real estate work is defined as that action...

  18. 32 CFR 644.30 - Preliminary real estate work.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 4 2014-07-01 2013-07-01 true Preliminary real estate work. 644.30 Section 644... PROPERTY REAL ESTATE HANDBOOK Project Planning Military (army and Air Force) and Other Federal Agencies § 644.30 Preliminary real estate work. (a) Preliminary real estate work is defined as that action...

  19. 32 CFR 644.30 - Preliminary real estate work.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 4 2012-07-01 2011-07-01 true Preliminary real estate work. 644.30 Section 644... PROPERTY REAL ESTATE HANDBOOK Project Planning Military (army and Air Force) and Other Federal Agencies § 644.30 Preliminary real estate work. (a) Preliminary real estate work is defined as that action...

  20. 32 CFR 644.30 - Preliminary real estate work.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 4 2013-07-01 2013-07-01 false Preliminary real estate work. 644.30 Section 644... PROPERTY REAL ESTATE HANDBOOK Project Planning Military (army and Air Force) and Other Federal Agencies § 644.30 Preliminary real estate work. (a) Preliminary real estate work is defined as that action...

  1. 10 CFR 830.206 - Preliminary documented safety analysis.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Preliminary documented safety analysis. 830.206 Section... Preliminary documented safety analysis. If construction begins after December 11, 2000, the contractor... category 1, 2, or 3 DOE nuclear facility must: (a) Prepare a preliminary documented safety analysis for...

  2. 10 CFR 830.206 - Preliminary documented safety analysis.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Preliminary documented safety analysis. 830.206 Section... Preliminary documented safety analysis. If construction begins after December 11, 2000, the contractor... category 1, 2, or 3 DOE nuclear facility must: (a) Prepare a preliminary documented safety analysis for...

  3. 10 CFR 830.206 - Preliminary documented safety analysis.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Preliminary documented safety analysis. 830.206 Section... Preliminary documented safety analysis. If construction begins after December 11, 2000, the contractor... category 1, 2, or 3 DOE nuclear facility must: (a) Prepare a preliminary documented safety analysis for...

  4. Turbulence flight director analysis and preliminary simulation

    NASA Technical Reports Server (NTRS)

    Johnson, D. E.; Klein, R. E.

    1974-01-01

    A control column and trottle flight director display system is synthesized for use during flight through severe turbulence. The column system is designed to minimize airspeed excursions without overdriving attitude. The throttle system is designed to augment the airspeed regulation and provide an indication of the trim thrust required for any desired flight path angle. Together they form an energy management system to provide harmonious display indications of current aircraft motions and required corrective action, minimize gust upset tendencies, minimize unsafe aircraft excursions, and maintain satisfactory ride qualities. A preliminary fixed-base piloted simulation verified the analysis and provided a shakedown for a more sophisticated moving-base simulation to be accomplished next. This preliminary simulation utilized a flight scenario concept combining piloting tasks, random turbulence, and discrete gusts to create a high but realistic pilot workload conducive to pilot error and potential upset. The turbulence director (energy management) system significantly reduced pilot workload and minimized unsafe aircraft excursions.

  5. Explosive volcanic deposits on Mars: Preliminary investigations

    NASA Technical Reports Server (NTRS)

    Crown, D. A.; Leshin, L. A.; Greeley, Ronald

    1987-01-01

    Two investigations were undertaken to examine possible large scale explosive volcanic deposits on Mars. The first includes an analysis of Viking Infrared Thermal Mapper (IRTM) data covering the vast deposits in the Amazonis, Memnonia, and Aeolis regions. These postulated ignimbrites have been previously mapped, and at least five high resolution nighttime IRTM data tracks cross the deposits. Preliminary analysis of the data covering Amazonis Planitia show that local features have anomalous thermal inertias but the ignimbrites as a whole do not consistently have significantly different thermal inertias from their surroundings. Preliminary photogeologic and IRTM studies of the large and small highland paterae have also begun. The purpose of IRTM studies of postulated Martian explosive volcanic deposits is to determine the physical properties of the proposed ignimbrites. If volcanic deposits are exposed at the surface, high thermal inertias, as are observed for Apollinaris Patera, should be present.

  6. Vibration of a rolling wheel— preliminary results

    NASA Astrophysics Data System (ADS)

    Hemsworth, B.

    1983-03-01

    Preliminary results are presented of the axial vibration of a railway wheel on a vehicle travelling at speeds of up to 100 miles/h. Frequency analysis shows that the wheel response is resonant, at modes of vibration which have been identified from static tests. Further developments of measurement and analysis techniques will be necessary before a more complete picture of the importance of wheel vibration on wheel/rail noise radiation can be determined.

  7. X-48B Preliminary Flight Test Results

    NASA Technical Reports Server (NTRS)

    Taylor, Brian R.

    2009-01-01

    This slide presentation reviews the preliminary Flight tests of the X-48B development program. The X-48B is a blended wing body aircraft that is being used to test various features of the BWB concept. The research concerns the following: (1) Turbofan Development, (2) Intelligent Flight Control and Optimization, (3) Airdata Calibration (4) Parameter Identification (i.e., Determination of the parameters of a mathematical model of a system based on observation of the system inputs and response.)

  8. Bunch compression for the TLC: Preliminary design

    SciTech Connect

    Kheifets, S.A.; Ruth, R.D.; Murray, J.J.; Fieguth, T.H.

    1988-12-01

    A preliminary design of a TLC bunch compressor as a two-stage device is described. The main parameters of the compressor, as well as results of some simulations, are presented. They show that the ideal system (no imperfections) does the job of transmitting transverse emittances without distortions (at least up to the second-order terms) producing at the same time the desired bunch length of 50 m. 9 refs., 6 figs., 4 tabs.

  9. [Tonsillectomy with a laser dissector. Preliminary report].

    PubMed

    Lenz, H

    1984-11-01

    A so called laser-dissector with a flexible beam guide system for tonsillectomy is described. With this instrument the tissue is irradiated for a very short time resulting in a coagulation of the peritonsillar tissue with closure of the small vessels even before mechanical dissection is performed. A preliminary report of 10 patients is given. The main advantage is that the procedure could be performed without or with much less bleeding as in tonsillectomy without using vasoconstrictors.

  10. Preliminary design study of lunar housing configurations

    NASA Technical Reports Server (NTRS)

    Reynolds, K. H.

    1992-01-01

    A preliminary design study assesses various configurations for habitation of the lunar surface. The study assumes an initial 4-man habitation module expandable to a 48-man concept. Through the numerous coupling combinations of identical modules, five basic configuration types are identified. A design model presents each configuration in light of certain issues. The issues include circulation, internal and external spatial characteristics, functional organizations, and future growth potential. The study discusses the attributes, potentials, and unique requirements of each configuration.

  11. Interferometer experiment on nimbus 3: preliminary results.

    PubMed

    Hanel, R; Conrath, B

    1969-09-19

    A Michelson interferometer spectrometer carried aboard the Nimbus 3 satellite, launched 14 April 1969, measured the spectrum between 400 and 2000 wave numbers with a resolution of 5 wave numbers. High-quality spectra have been obtained on a global scale, and preliminary results indicate that the absorption bands of carbon dioxide, water vapor, and ozone can be used to obtain vertical distributions of temperature, water vapor, and ozone.

  12. High intensity copper atom beam - Preliminary results

    NASA Technical Reports Server (NTRS)

    Kelly, A. J.; Santavicca, D.

    1973-01-01

    The development of a nozzle which gas-dynamically accelerates neutral copper atoms at controlled energy levels and flux rates suitable for the investigation of inelastic copper atom collision processes is reported. Preliminary test data demonstrate that vapor-deposited rhenium nozzles do not degrade in the presence of copper vapor at high temperatures. Operation with high purity helium gas at nozzle stagnation temperatures in the range 2650-2700 K and total stagnation pressures from 1/4 to 2 atm with continuous copper atom flux rates of approximately 10 to the 18th power per second has been maintained, for a total time of 8-1/2 h to date.

  13. Pioneer 10 infrared radiometer experiment: preliminary results.

    PubMed

    Chase, S C; Ruiz, R D; Münch, G; Neugebauer, G; Schroeder, M; Trafton, L M

    1974-01-25

    Thermal maps of Jupiter at 20 and 40 micrometers show structure closely related to the visual appearance of the planet. Peak brightness temperatures of 126 degrees and 145 degrees K have been measured on the South Equatorial Belt, for the 20- and 40-micrometer channels, respectively. Corresponding values for the South Tropical Zone are 120 degrees and 138 degrees K. No asymmetries between the illuminated sunlit and nonilluminated parts of the disk were found. A preliminary discussion of the data, in terms of simple radiative equilibrium models, is presented. The net thermal energy of the planet as a whole is twice the solar energy input.

  14. Preliminary Cost Model for Space Telescopes

    NASA Technical Reports Server (NTRS)

    Stahl, H. Philip; Prince, F. Andrew; Smart, Christian; Stephens, Kyle; Henrichs, Todd

    2009-01-01

    Parametric cost models are routinely used to plan missions, compare concepts and justify technology investments. However, great care is required. Some space telescope cost models, such as those based only on mass, lack sufficient detail to support such analysis and may lead to inaccurate conclusions. Similarly, using ground based telescope models which include the dome cost will also lead to inaccurate conclusions. This paper reviews current and historical models. Then, based on data from 22 different NASA space telescopes, this paper tests those models and presents preliminary analysis of single and multi-variable space telescope cost models.

  15. Automated CPX support system preliminary design phase

    NASA Technical Reports Server (NTRS)

    Bordeaux, T. A.; Carson, E. T.; Hepburn, C. D.; Shinnick, F. M.

    1984-01-01

    The development of the Distributed Command and Control System (DCCS) is discussed. The development of an automated C2 system stimulated the development of an automated command post exercise (CPX) support system to provide a more realistic stimulus to DCCS than could be achieved with the existing manual system. An automated CPX system to support corps-level exercise was designed. The effort comprised four tasks: (1) collecting and documenting user requirements; (2) developing a preliminary system design; (3) defining a program plan; and (4) evaluating the suitability of the TRASANA FOURCE computer model.

  16. Preliminary Airspace Operations Simulations Findings Report

    NASA Technical Reports Server (NTRS)

    2005-01-01

    Provides preliminary findings of the initial series (normal operations and contingency management) of airspace operations simulations. The key elements of this report discuss feedback from controller subjects for UAS flight above FL430. Findings provide initial evaluation of routine UAS operations above dense ARTCC airspace (ZOB), and identify areas of further research, policy direction and procedural development. This document further serves as an addendum to the detailed AOS simulation plan (Deliverable SIM001), incorporating feedback from FAA air traffic personnel and Access 5 IPTs.

  17. Preliminary Results from the CHIPS Mission

    NASA Astrophysics Data System (ADS)

    Hurwitz, M.; Sasseen, T.; Marchant, W.; Sirk, M.; UC Berkeley CHIPS Instrument Team; SpaceDev Inc. CHIPS Spacecraft Team

    2003-03-01

    We present preliminary results from the Cosmic Hot Interstellar Plasma Spectrometer (``CHIPS") mission. CHIPS contains a grazing incidence spectrometer optimized for diffuse emission in the extreme ultraviolet band between 90 and 260 Angstroms, with a peak resolution of about 1.4 Angstroms. The spectrometer should provide unique and important new data on hot gas within the ``local bubble" of the interstellar medium. At the time this abstract was submitted, CHIPS had been successfully launched into a polar orbit, but commissioning of the spacecraft had only just begun. CHIPS is supported by NASA grant NAG5-5213.

  18. Preliminary flight prototype silver ion monitoring system

    NASA Technical Reports Server (NTRS)

    Brady, J.

    1974-01-01

    The design, fabrication, and testing of a preliminary flight prototype silver ion monitoring system based on potentiometric principles and utilizing a solid-state silver sulfide electrode paired with a pressurized double-junction reference electrode housing a replaceable electrolyte reservoir is described. The design provides automatic electronic calibration utilizing saturated silver bromide solution as a silver ion standard. The problem of loss of silver ion from recirculating fluid, its cause, and corrective procedures are reported. The instability of the silver sulfide electrode is discussed as well as difficulties met in implementing the autocalibration procedure.

  19. Preliminary summary of the ETF conceptual studies

    NASA Technical Reports Server (NTRS)

    Seikel, G. R.; Bercaw, R. W.; Pearson, C. V.; Owens, W. R.

    1978-01-01

    Power plant studies have shown the attractiveness of MHD topped steam power plants for baseload utility applications. To realize these advantages, a three-phase development program was initiated. In the first phase, the engineering data and experience were developed for the design and construction of a pilot plant, the Engineering Test Facility (ETF). Results of the ETF studies are reviewed. These three parallel independent studies were conducted by industrial teams led by the AVCO Everett Research Laboratory, the General Electric Corporation, and the Westinghouse Corporation. A preliminary analysis and the status of the critical evaluation of these results are presented.

  20. MSFC integrated experiments preliminary report. [for the Skylab program

    NASA Technical Reports Server (NTRS)

    1974-01-01

    Skylab experiments are described and their preliminary results are reported. The types of experiments described include medical, earth resources, space physics, space manufacturing, and spacecraft design.

  1. Stereoplotting Hominid Brain Endocasts : Some Preliminary Results

    NASA Astrophysics Data System (ADS)

    Holloway, Ralph L.

    1980-07-01

    To objectively and quantitatively demonstrate regional differences in brain endocast morphology, traditional anthropometric caliper measurements must be replaced by a system providing not only localness, but homology and reasonable freedom from allometric distortion. Stereoplotting the radial distances from endocast surface (the closest point to the once underlying brain cortex) to a homologous center every ten degrees provides some 300+ data points for each dorsal endocast surface, thus giving the requisite localness. These measurements provide a large matrix of data suitable for a number of multivariate statistical techniques, and the translation of such data and analyses to readily visualized maps, which can then be compared in relation to both taxonomic and functional knowledge about the cerebral surface. This paper descri-bes some preliminary results from using such methods on a sample of 64 undistorted endocasts composed of both pongids and fossil hominids. While sample sizes within taxonomic groups need to be augmented, the preliminary and tentative pilot studies conducted so far suggest that the method has excellent potential, and that two major areas of the brain endocast surface show the greatest shape changes : 1) the posterior association areas (inferior parietal lobule); 2) the anterior prefrontal areas.

  2. A preliminary neutron crystallographic study of thaumatin

    SciTech Connect

    Teixeira, Susana C. M.; Blakeley, Matthew P.; Leal, Ricardo M. F.; Mitchell, Edward P.; Forsyth, V. Trevor

    2008-05-01

    Preliminary neutron crystallographic data from the sweet protein thaumatin have been recorded using the LADI-III diffractometer at the Institut Laue Langevin (ILL). The results illustrate the feasibility of a full neutron structural analysis aimed at further understanding the molecular basis of the perception of sweet taste. Such an analysis will exploit the use of perdeuterated thaumatin. A preliminary neutron crystallographic study of the sweet protein thaumatin is presented. Large hydrogenated crystals were prepared in deuterated crystallization buffer using the gel-acupuncture method. Data were collected to a resolution of 2 Å on the LADI-III diffractometer at the Institut Laue Langevin (ILL). The results demonstrate the feasibility of a full neutron crystallographic analysis of this structure aimed at providing relevant information on the location of H atoms, the distribution of charge on the protein surface and localized water in the structure. This information will be of interest for understanding the specificity of thaumatin–receptor interactions and will contribute to further understanding of the molecular mechanisms underlying the perception of taste.

  3. Preliminary impression techniques for microstomia patients.

    PubMed

    Kumar, K Aswini; Bhat, Vinaya; Nair, K Chandrasekheran; Suresh, Reshma

    2016-01-01

    The Prosthetic rehabilitation of microstomia patients presents difficulties at all the stages. The difficulty starts with the preliminary impression making. This is due to the tongue rigidity and the decreased oral opening. A maximum oral opening which is smaller than the size of the tray can make prosthetic treatment challenging. Due to the restricted mouth opening, insertion and removal of the impression trays is extremely cumbersome and various modifications of the trays have been used in the past. Among these are the flexible trays and the sectional trays used with different modes of reassembling the segments extra orally after the impression is made. This article reviews the literature published from 1971 to 2015 concerning preliminary impression techniques used in making impressions for patients with microstomia based on various tray designs. An electronic search was performed across three databases (PubMed, Science Direct and Google Scolar) for relevant citations. The keywords/combinations used for the search were microstomia, limited/constricted/restricted mouth opening/oral access, trismus, sectional trays, impressions and prosthetic/prosthodontic rehabilitation. The search was limited to papers written in English which resulted in a total of 45 related articles of which 17 articles were included for discussion of this review.

  4. Preliminary Results of Field Emission Cathode Tests

    NASA Technical Reports Server (NTRS)

    Sovey, James S.; Kovaleski, Scott D.

    2001-01-01

    Preliminary screening tests of field emission cathodes such as chemical vapor deposited (CVD) diamond, textured pyrolytic graphite, and textured copper were conducted at background pressures typical of electric thruster test facilities to assess cathode performance and stability. Very low power electric thrusters which provide tens to hundreds micronewtons of thrust may need field emission neutralizers that have a capability of tens to hundreds of microamperes. From current voltage characteristics, it was found that the CVD diamond and textured metals cathodes clearly satisfied the Fowler-Nordheim emission relation. The CVD diamond and a textured copper cathode had average current densities of 270 and 380 mA/sq cm, respectively, at the beginning-of-life. After a few hours of operation the cathode emission currents degraded by 40 to 75% at background pressures in the 10(exp -5) Pa to 10(exp -4) Pa range. The textured pyrolytic graphite had a modest current density at beginning-of-life of 84 mA/sq cm, but this cathode was the most stable of all. Extended testing of the most promising cathodes is warranted to determine if current degradation is a burn-in effect or whether it is a long-term degradation process. Preliminary experiments with ferroelectric emission cathodes, which are ceramics with spontaneous electric polarization, were conducted. Peak current densities of 30 to 120 mA/sq cm were obtained for pulse durations of about 500 ns in the 10(exp -4) Pa pressure range.

  5. Preliminary Hazards Analysis Plasma Hearth Process

    SciTech Connect

    Aycock, M.; Coordes, D.; Russell, J.; TenBrook, W.; Yimbo, P.

    1993-11-01

    This Preliminary Hazards Analysis (PHA) for the Plasma Hearth Process (PHP) follows the requirements of United States Department of Energy (DOE) Order 5480.23 (DOE, 1992a), DOE Order 5480.21 (DOE, 1991d), DOE Order 5480.22 (DOE, 1992c), DOE Order 5481.1B (DOE, 1986), and the guidance provided in DOE Standards DOE-STD-1027-92 (DOE, 1992b). Consideration is given to ft proposed regulations published as 10 CFR 830 (DOE, 1993) and DOE Safety Guide SG 830.110 (DOE, 1992b). The purpose of performing a PRA is to establish an initial hazard categorization for a DOE nuclear facility and to identify those processes and structures which may have an impact on or be important to safety. The PHA is typically performed during and provides input to project conceptual design. The PRA then is followed by a Preliminary Safety Analysis Report (PSAR) performed during Title I and II design. This PSAR then leads to performance of the Final Safety Analysis Report performed during construction, testing, and acceptance and completed before routine operation. Radiological assessments indicate that a PHP facility, depending on the radioactive material inventory, may be an exempt, Category 3, or Category 2 facility. The calculated impacts would result in no significant impact to offsite personnel or the environment. Hazardous material assessments indicate that a PHP facility will be a Low Hazard facility having no significant impacts either onsite or offsite to personnel and the environment.

  6. Pioneer Saturn infrared radiometer - Preliminary results

    NASA Technical Reports Server (NTRS)

    Ingersoll, A. P.; Neugebauer, G.; Orton, G. S.; Muench, G.; Chase, S. C.

    1980-01-01

    Preliminary results of the infrared radiometer experiment on Pioneer Saturn are reported. The instrument made use of two broadband channels centered at 20 and 45 microns which scan at a fixed 75-deg angle with respect to the spacecraft spin axis to acquire 10,000 image pairs of Saturn and its rings in the 2.5 h before closest approach, as well as several observations of Titan. The intensities of radiation observed in both bands indicate an effective temperature of 94.4 + or - 3 K for the planet, implying a total emission greater than twice the absorbed sunlight. Infrared data also indicates a molecular abundance of 0.85 for H2 relative to H2 + He, which can be improved by comparing the derived temperature profiles and radio occultation data. Planetary temperatures are found to range from a minimum of 83 to 140 K at the 1 bar level, with differences of 2.5 K between belts and zones up to the 0.06-bar level, while ring temperatures range from 60 to 70 K on the illuminated side and from less than 60 to 67 K in the planet's shadow and average 55 K on the unilluminated side. Preliminary estimates indicate a 45-micron brightness temperature of 80 + or - 10 K for Titan.

  7. Defining resilience: A preliminary integrative literature review

    USGS Publications Warehouse

    Wilt, Bonnie; Long, Suzanna K.; Shoberg, Thomas G.

    2016-01-01

    The term “resilience” is ubiquitous in technical literature; it appears in numerous forms, such as resilience, resiliency, or resilient, and each use may have a different definition depending on the interpretation of the writer. This creates difficulties in understanding what is meant by ‘resilience’ in any given use case, especially in discussions of interdisciplinary research. To better understand this problem, this research constructs a preliminary integrative literature review to map different definitions, applications and calculation methods of resilience invoked within critical infrastructure applications. The preliminary review uses a State-of-the-Art Matrix (SAM) analysis to characterize differences in definition across disciplines and between regions. Qualifying the various usages of resilience will produce a greater precision in the literature and a deeper insight into types of data required for its evaluation, particularly with respect to critical infrastructure calculations and how such data may be analyzed. Results from this SAM analysis will create a framework of key concepts as part of the most common applications for “resilient critical infrastructure” modeling.

  8. Preliminary design for a maglev development facility

    SciTech Connect

    Coffey, H.T.; He, J.L.; Chang, S.L.; Bouillard, J.X.; Chen, S.S.; Cai, Y.; Hoppie, L.O.; Lottes, S.A.; Rote, D.M. ); Zhang, Z.Y. ); Myers, G.; Cvercko, A. ); Williams, J.R. )

    1992-04-01

    A preliminary design was made of a national user facility for evaluating magnetic-levitation (maglev) technologies in sizes intermediate between laboratory experiments and full-scale systems. A technical advisory committee was established and a conference was held to obtain advice on the potential requirements of operational systems and how the facility might best be configured to test these requirements. The effort included studies of multiple concepts for levitating, guiding, and propelling maglev vehicles, as well as the controls, communications, and data-acquisition and -reduction equipment that would be required in operating the facility. Preliminary designs for versatile, dual 2-MVA power supplies capable of powering attractive or repulsive systems were developed. Facility site requirements were identified. Test vehicles would be about 7.4 m (25 ft) long, would weigh form 3 to 7 metric tons, and would operate at speeds up to 67 m/s (150 mph) on a 3.3-km (2.05-mi) elevated guideway. The facility would utilize modular vehicles and guideways, permitting the substitution of levitation, propulsion, and guideway components of different designs and materials for evaluation. The vehicle would provide a test cell in which individual suspension or propulsion components or subsystems could be tested under realistic conditions. The system would allow economical evaluation of integrated systems under varying weather conditions and in realistic geometries.

  9. ISSA/TSS power preliminary design

    NASA Technical Reports Server (NTRS)

    Main, John A.

    1996-01-01

    A projected power shortfall during the initial utilization flights of the International Space Station Alpha (ISSA) has prompted an inquiry into the use of the Tethered Satellite System (TSS) to provide station power. The preliminary design of the combined ISSA/TSS system is currently underway in the Preliminary Design Office at the Marshall Space Flight Center. This document focuses on the justification for using a tether system on space station, the physical principles behind such a system, and how it might be operated to best utilize its capabilities. The basic components of a simple DC generator are a magnet of some type and a conductive wire. Moving the wire through the magnetic field causes forces to be applied to the electric charges in the conductor, and thus current is induced to flow. This simple concept is the idea behind generating power with space-borne tether systems. The function of the magnet is performed by the earth's magnetic field, and orbiting a conductive tether about the earth effectively moves the tether through the field.

  10. Preliminary remediation goals for ecological endpoints

    SciTech Connect

    Efroymson, R.A.; Suter, G.W. II; Sample, B.E.; Jones, D.S.

    1996-07-01

    Preliminary remediation goals (PRGs) are useful for risk assessment and decision making at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) sites. PRGs are upper concentration limits for specific chemicals in specific environmental media that are anticipated to protect human health or the environment. They can be used for multiple remedial investigations at multiple facilities. In addition to media and chemicals of potential concern, the development of PRGs generally requires some knowledge or anticipation of future land use. In Preliminary Remediation Goals for Use at the U.S. Department of Energy Oak Ridge Operations Office (Energy Systems 1995), PRGs intended to protect human health were developed with guidance from Risk Assessment Guidance for Superfund: Volume I - Human Health Evaluation Manual, Part B (RAGS) (EPA 1991). However, no guidance was given for PRGs based on ecological risk. The numbers that appear in this volume have, for the most part, been extracted from toxicological benchmarks documents for Oak Ridge National Laboratory (ORNL) and have previously been developed by ORNL. The sources of the quantities, and many of the uncertainties associated with their derivation, are described in this technical memorandum.

  11. 33 CFR 1.07-25 - Preliminary matters.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Preliminary matters. 1.07-25 Section 1.07-25 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL GENERAL PROVISIONS Enforcement; Civil and Criminal Penalty Proceedings § 1.07-25 Preliminary matters....

  12. 33 CFR 1.07-25 - Preliminary matters.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Preliminary matters. 1.07-25 Section 1.07-25 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL GENERAL PROVISIONS Enforcement; Civil and Criminal Penalty Proceedings § 1.07-25 Preliminary matters....

  13. 33 CFR 1.07-25 - Preliminary matters.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Preliminary matters. 1.07-25 Section 1.07-25 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL GENERAL PROVISIONS Enforcement; Civil and Criminal Penalty Proceedings § 1.07-25 Preliminary matters....

  14. 33 CFR 1.07-25 - Preliminary matters.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Preliminary matters. 1.07-25 Section 1.07-25 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL GENERAL PROVISIONS Enforcement; Civil and Criminal Penalty Proceedings § 1.07-25 Preliminary matters....

  15. 33 CFR 1.07-25 - Preliminary matters.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Preliminary matters. 1.07-25 Section 1.07-25 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL GENERAL PROVISIONS Enforcement; Civil and Criminal Penalty Proceedings § 1.07-25 Preliminary matters....

  16. 10 CFR 830.206 - Preliminary documented safety analysis.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Preliminary documented safety analysis. 830.206 Section 830.206 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.206 Preliminary documented safety analysis. If construction begins after December 11, 2000, the...

  17. 10 CFR 824.6 - Preliminary notice of violation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Preliminary notice of violation. 824.6 Section 824.6 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY VIOLATIONS § 824.6 Preliminary notice of violation. (a) In order to begin a proceeding...

  18. Preliminary Opto-Mechanical Design for the X2000 Transceiver

    NASA Technical Reports Server (NTRS)

    Hemmati, H.; Page, N. A.

    2000-01-01

    Preliminary optical design and mechanical conceptual design for a 30 cm aperture transceiver are described. A common aperture is used for both transmit and receive. Special attention was given to off-axis and scattered light rejection and isolation of the receive channel from the transmit channel. Requirements, details of the design and preliminary performance analysis of the transceiver are provided.

  19. 40 CFR 8.6 - Preliminary environmental review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Preliminary environmental review. 8.6 Section 8.6 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL IMPACT ASSESSMENT OF NONGOVERNMENTAL ACTIVITIES IN ANTARCTICA § 8.6 Preliminary environmental review. (a) Unless...

  20. 40 CFR 8.6 - Preliminary environmental review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Preliminary environmental review. 8.6 Section 8.6 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL ENVIRONMENTAL IMPACT ASSESSMENT OF NONGOVERNMENTAL ACTIVITIES IN ANTARCTICA § 8.6 Preliminary environmental review. (a) Unless...

  1. 18 CFR 5.16 - Preliminary licensing proposal.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Preliminary licensing... Preliminary licensing proposal. (a) No later than 150 days prior to the deadline for filing a new or subsequent license application, if applicable, the potential applicant must file for comment a...

  2. 18 CFR 5.16 - Preliminary licensing proposal.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Preliminary licensing... Preliminary licensing proposal. (a) No later than 150 days prior to the deadline for filing a new or subsequent license application, if applicable, the potential applicant must file for comment a...

  3. 32 CFR 644.30 - Preliminary real estate work.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... determined that it is practicable to proceed. (c) Preliminary real estate work on Air Force projects will be... 32 National Defense 4 2011-07-01 2011-07-01 false Preliminary real estate work. 644.30 Section 644... PROPERTY REAL ESTATE HANDBOOK Project Planning Military (army and Air Force) and Other Federal...

  4. Preliminary design study for an atomospheric science facility

    NASA Technical Reports Server (NTRS)

    Hutchison, R.

    1972-01-01

    The activities and results of the Atmospheric Science Facility preliminary design study are reported. The objectives of the study were to define the scientific goals, to determine the range of experiment types, and to develop the preliminary instrument design requirements for a reusable, general purpose, optical research facility for investigating the earth's atmosphere from a space shuttle orbital vehicle.

  5. Preliminary Proactive Sample Size Determination for Confirmatory Factor Analysis Models

    ERIC Educational Resources Information Center

    Koran, Jennifer

    2016-01-01

    Proactive preliminary minimum sample size determination can be useful for the early planning stages of a latent variable modeling study to set a realistic scope, long before the model and population are finalized. This study examined existing methods and proposed a new method for proactive preliminary minimum sample size determination.

  6. 28 CFR 2.48 - Revocation: Preliminary interview.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Revocation: Preliminary interview. 2.48....48 Revocation: Preliminary interview. (a) Interviewing officer. A parolee who is retaken on a warrant... violated his parole as charged, and if so, whether a revocation hearing should be conducted. The...

  7. 45 CFR 671.15 - Publication of preliminary determination

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Publication of preliminary determination 671.15... Publication of preliminary determination Prior to any designation or redesignation of substances pursuant to... Environmental Protection Agency and other federal agencies, within 30 days after the date of publication...

  8. 33 CFR 279.7 - Information collection and preliminary analysis.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... preliminary analysis. 279.7 Section 279.7 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF... collection and preliminary analysis. (a) Data search. This effort consists of collecting existing data and... analysis comparing the two parts and their relationship to authorized project purposes and...

  9. 10 CFR 824.6 - Preliminary notice of violation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Preliminary notice of violation. 824.6 Section 824.6 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY VIOLATIONS § 824.6 Preliminary notice of violation. (a) In order to begin a proceeding...

  10. 10 CFR 824.6 - Preliminary notice of violation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Preliminary notice of violation. 824.6 Section 824.6 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY VIOLATIONS § 824.6 Preliminary notice of violation. (a) In order to begin a proceeding...

  11. 10 CFR 824.6 - Preliminary notice of violation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Preliminary notice of violation. 824.6 Section 824.6 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY VIOLATIONS § 824.6 Preliminary notice of violation. (a) In order to begin a proceeding...

  12. 10 CFR 824.6 - Preliminary notice of violation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Preliminary notice of violation. 824.6 Section 824.6 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY VIOLATIONS § 824.6 Preliminary notice of violation. (a) In order to begin a proceeding...

  13. Preliminary design of pseudo satellites: Basic methods and feasibility criteria

    NASA Astrophysics Data System (ADS)

    Klimenko, N. N.

    2016-12-01

    Analytical models of weight and energy balances, aerodynamic models, and solar irradiance models to perform pseudo-satellite preliminary design are presented. Feasibility criteria are determined in accordance with the aim of preliminary design dependent on mission scenario and type of payload.

  14. 10 CFR 830.206 - Preliminary documented safety analysis.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Preliminary documented safety analysis. 830.206 Section 830.206 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.206... category 1, 2, or 3 DOE nuclear facility must: (a) Prepare a preliminary documented safety analysis for...

  15. 36 CFR 1007.4 - Preliminary processing of requests.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false Preliminary processing of... FREEDOM OF INFORMATION ACT § 1007.4 Preliminary processing of requests. (a) Scope of requests. Unless a... containing trade secrets or commercial or financial information submitted by a person outside of the...

  16. 78 FR 64478 - Request for Comments on the Preliminary Cybersecurity Framework

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-29

    ... National Institute of Standards and Technology Request for Comments on the Preliminary Cybersecurity... comments on the preliminary version of the Cybersecurity Framework (``preliminary Framework''). The... Executive Order 13636, ``Improving Critical Infrastructure Cybersecurity'' (``Executive Order''). Under...

  17. 76 FR 52945 - Chlorpyrifos Registration Review; Preliminary Human Health Risk Assessment; Extension of Comment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-24

    ... AGENCY Chlorpyrifos Registration Review; Preliminary Human Health Risk Assessment; Extension of Comment... availability of the chlorpyrifos registration review; preliminary human health risk assessment. This document... for the chlorpyrifos reregistration review, preliminary human health risk assessment, established...

  18. Breakthrough Propulsion Physics Workshop Preliminary Results

    NASA Technical Reports Server (NTRS)

    Millis, Marc G.

    1997-01-01

    In August, 1997, a NASA workshop was held to assess the prospects emerging from physics that might lead to creating the ultimate breakthroughs in space transportation: propulsion that requires no propellant mass, attaining the maximum transit speeds physically possible, and breakthrough methods of energy production to power such devices. Because these propulsion goals are presumably far from fruition, a special emphasis was to identify affordable, near-term, and credible research that could make measurable progress toward these propulsion goals. Experiments and theories were discussed regarding the coupling of gravity and electromagnetism, vacuum fluctuation energy, warp drives and wormholes, and superluminal quantum tunneling. Preliminary results of this workshop are presented, along with the status of the Breakthrough Propulsion Physics program that conducted this workshop.

  19. SLS-1 flight experiments preliminary significant results

    NASA Astrophysics Data System (ADS)

    1992-01-01

    Spacelab Life Sciences-1 (SLS-1) is the first of a series of dedicated life sciences Spacelab missions designed to investigate the mechanisms involved in the physiological adaptation to weightlessness and the subsequent readaptation to 1 gravity (1 G). Hypotheses generated from the physiological effects observed during earlier missions led to the formulation of several integrated experiments to determine the underlying mechanisms responsible for the observed phenomena. The 18 experiments selected for flight on SLS-1 investigated the cardiovascular, cardiopulmonary, regulatory physiology, musculoskeletal, and neuroscience disciplines in both human and rodent subjects. The SLS-1 preliminary results gave insight to the mechanisms involved in the adaptation to the microgravity environment and readaptation when returning to Earth. The experimental results will be used to promote health and safety for future long duration space flights and, as in the past, will be applied to many biomedical problems encountered here on Earth.

  20. Repository Subsurface Preliminary Fire Hazard Analysis

    SciTech Connect

    Richard C. Logan

    2001-07-30

    This fire hazard analysis identifies preliminary design and operations features, fire, and explosion hazards, and provides a reasonable basis to establish the design requirements of fire protection systems during development and emplacement phases of the subsurface repository. This document follows the Technical Work Plan (TWP) (CRWMS M&O 2001c) which was prepared in accordance with AP-2.21Q, ''Quality Determinations and Planning for Scientific, Engineering, and Regulatory Compliance Activities''; Attachment 4 of AP-ESH-008, ''Hazards Analysis System''; and AP-3.11Q, ''Technical Reports''. The objective of this report is to establish the requirements that provide for facility nuclear safety and a proper level of personnel safety and property protection from the effects of fire and the adverse effects of fire-extinguishing agents.

  1. IBIS detector performance during calibration - preliminary analysis

    NASA Astrophysics Data System (ADS)

    Bazzano, A.; Bird, A. J.; Laurent, P.; Malaguti, G.; Quadrini, E. M.; Segreto, A.; Volkmer, R.; del Santo, M.; Gabriele, M.; Tikkanen, T.

    2003-11-01

    The IBIS telescope is a high angular resolution gamma-ray imager due to be launched on the INTEGRAL satellite on October 17, 2002. The scientific goal of IBIS is to study astrophysical processes from celestial sources and diffuse regions in the hard X-ray and soft gamma-ray domains. IBIS features a coded aperture imaging system and a novel large area (~3000cm2) multilayer pixellated detector which utilises both cadmium telluride (16,384 detectors) and caesium iodide elements (4096 detectors) surrounded by a BGO active veto shield. We present an overview of, and preliminary analysis from, the IBIS calibration campaign. The performance of each pixel has been characterised, and hence the scientific performance of the IBIS detector system as a whole can now be established.

  2. Vulvodynia and fungal association: a preliminary report.

    PubMed

    Ventolini, G; Gygax, S E; Adelson, M E; Cool, D R

    2013-08-01

    Vulvodynia (vulvar pain syndrome) is a chronic multifactorial disease affecting almost 13 million women in the USA and can lead to morbidity and a reduced quality of life. We hypothesize that an initial microbiological insult in the vagina causes modifications in the biological vaginal milieu and/or an alteration on the lactobacilli flora. The vaginal milieu responds to the insult by developing an inflammatory reaction with abnormal cytokine production. These hypotheses were tested quantifying vaginal lactobacillus and cytokines, in patients with vulvodynia compared to matched healthy controls. Our preliminary data suggest a vaginal flora alteration and an immunological response involving Candida in patients with vulvodynia. Ongoing studies will assist us to clarify these findings.

  3. Preliminary calibration of a generic scramjet combustor

    NASA Technical Reports Server (NTRS)

    Jacobs, P. A.; Morgan, R. G.; Rogers, R. C.; Wendt, M.; Brescianini, C.; Paull, A.; Kelly, G.

    1991-01-01

    The results of a preliminary investigation of the combustion of hydrogen fuel at hypersonic flow conditions are provided. The tests were performed in a generic, constant-area combustor model with test gas supplied by a free-piston-driven reflected-shock tunnel. Static pressure measurements along the combustor wall indicated that burning did occur for combustor inlet conditions of P(static) approximately equal to 19kPa, T(static) approximately equal to 1080 K, and U approximately equal to 3630 m/s with a fuel equivalence ratio approximately equal to 0.9. These inlet conditions were obtained by operating the tunnel with stagnation enthalpy approximately equal to 8.1 MJ/kg, stagnation pressure approximately equal to 52 MPa, and a contoured nozzle with a nominal exit Mach number of 5.5.

  4. Preliminary design study. Shuttle modular scanning spectroradiometer

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Fundamental concepts on which to base a detailed design for a Shuttle Modular Scanning Spectroradiometer were developed, and a preliminary design is presented. The recommended design features modularity and flexibility. It includes a 75-cm f/1.7-telescope assembly in an all-reflective Schmidt configuration, a solid state scan system (pushbroom) with high resolution over a 15 deg field of view, and ten detector channels covering the spectral range from 0.45 to 12.5 micrometers. It uses charge transfer device techniques to accommodate a large number of detector elements for earth observation measurements. Methods for in-flight radiometric calibration, for image motion compensation, and for data processing are described. Recommendations for ground support equipment are included, and interfaces with the shuttle orbiter vehicle are illustrated.

  5. Advanced solar concentrator: Preliminary and detailed design

    NASA Technical Reports Server (NTRS)

    Bell, D. M.; Maraschin, R. A.; Matsushita, M. T.; Erskine, D.; Carlton, R.; Jakovcevic, A.; Yasuda, A. K.

    1981-01-01

    A single reflection point focusing two-axis tracking paraboloidal dish with a reflector aperture diameter of approximately 11 m has a reflective surface made up of 64 independent, optical quality gores. Each gore is a composite of a thin backsilvered mirror glass face sheet continuously bonded to a contoured substrate of lightweight, rigid cellular glass. The use of largely self-supporting gores allows a significant reduction in the weight of the steel support structure as compared to alternate design concepts. Primary emphasis in the preliminary design package for the low-cost, low-weight, mass producible concentrator was placed on the design of the higher cost subsystems. The outer gore element was sufficiently designed to allow fabrication of prototype gores.

  6. Lockheed Martin T-Rex: Preliminary report

    SciTech Connect

    1997-07-31

    T-Rex is a robot which may be used in toxic or flammable environments. The assessment of the T-Rex conducted at the Lockheed Martin facility was limited in its scope. The scope of the assessment was directed by the type of equipment being used and the amount of accessibility to the equipment. Due to severe time constraints--the assessment was conducted in one day--human factors interface activities were limited. This should be considered a preliminary assessment. This report covers aspects of the technology that were available to the assessment team. Recommendations for future evaluation of this technology are also included. The contents are as follows: Electrical Considerations; General Electrical Consideration; Trailing Cables; Grounding; Surface High Voltage Distribution; Low and Medium Voltage Alternating Current Circuits; Potential for Harmful Human Factor Incidents and Enterprise Disablement; Exclusion Zone Emergency Maintenance; and Recommendations.

  7. Preliminary Proton Spin Asymmetry Results from SANE

    NASA Astrophysics Data System (ADS)

    Maxwell, James

    2010-11-01

    The Spin Asymetries of the Nucleon Experiment (SANE) is a measurement of parallel and near-perpendicular double spin asymmetries in an inclusive electron scattering experiment, with the aim of calculating the spin asymmetry of the proton A^1p and spin structure function g^2p. Using Thomas Jefferson National Accelerator Facility's polarized electron beam and the University of Virginia's polarized frozen ammonia (^14NH3) target in Hall C, the experiment ran in 2009, collecting data in a Q^2 region from 2.5 to 6.5 GeV^2 in a Bjorken x region of 0.3 to 0.8. Particle detection was accomplished using the Big Electron Telescope Array (BETA), a novel non-magnetic detector array with a 194 msr acceptance. This talk will address the progress of the analysis toward the calculation of the proton spin asymmetry and structure functions, including calibration of the BETA detectors, event selection, and preliminary results.

  8. Preliminary Findings from the SHERE ISS Experiment

    NASA Technical Reports Server (NTRS)

    Hall, Nancy R.; McKinley, Gareth H.; Erni, Philipp; Soulages, Johannes; Magee, Kevin S.

    2009-01-01

    The Shear History Extensional Rheology Experiment (SHERE) is an International Space Station (ISS) glovebox experiment designed to study the effect of preshear on the transient evolution of the microstructure and viscoelastic tensile stresses for monodisperse dilute polymer solutions. The SHERE experiment hardware was launched on Shuttle Mission STS-120 (ISS Flight 10A) on October 22, 2007, and 20 fluid samples were launched on Shuttle Mission STS-123 (ISS Flight 10/A) on March 11, 2008. Astronaut Gregory Chamitoff performed experiments during Increment 17 on the ISS between June and September 2008. A summary of the ten year history of the hardware development, the experiment's science objectives, and Increment 17's flight operations are discussed in the paper. A brief summary of the preliminary science results is also discussed.

  9. A computer controlled pulsatile pump: preliminary study.

    PubMed

    Zwarts, M S; Topaz, S R; Jones, D N; Kolff, W J

    1996-12-01

    A Stepper Motor Driven Reciprocating Pump (SDRP) can replace roller pumps and rotary pumps for cardio pulmonary bypass, hemodialysis and regional perfusion. The blood pumping ventricles are basically the same as ventricles used for air driven artificial hearts and ventricular assist devices. The electric stepper motor uses a flexible linkage belt to produce a reciprocating movement, which pushes a hard sphere into the diaphragm of the blood ventricles. The SDRP generates pulsatile flow and has a small priming volume. The preset power level of the motor driver limits the maximum potential outflow pressure, so the driver acts as a safety device. A double pump can be made by connecting two fluid pumping chambers to opposing sides of the motor base. Each pump generates pulsatile flow. Pressure and flow studies with water were undertaken. Preliminary blood studies showed low hemolysis, even when circulating a small amount of blood up to 16 hours.

  10. Preliminary Model of Porphyry Copper Deposits

    USGS Publications Warehouse

    Berger, Byron R.; Ayuso, Robert A.; Wynn, Jeffrey C.; Seal, Robert R., II

    2008-01-01

    The U.S. Geological Survey (USGS) Mineral Resources Program develops mineral-deposit models for application in USGS mineral-resource assessments and other mineral resource-related activities within the USGS as well as for nongovernmental applications. Periodic updates of models are published in order to incorporate new concepts and findings on the occurrence, nature, and origin of specific mineral deposit types. This update is a preliminary model of porphyry copper deposits that begins an update process of porphyry copper models published in USGS Bulletin 1693 in 1986. This update includes a greater variety of deposit attributes than were included in the 1986 model as well as more information about each attribute. It also includes an expanded discussion of geophysical and remote sensing attributes and tools useful in resource evaluations, a summary of current theoretical concepts of porphyry copper deposit genesis, and a summary of the environmental attributes of unmined and mined deposits.

  11. Preliminary results from MERIS Land Algorithm

    NASA Astrophysics Data System (ADS)

    Gobron, N.; Pinty, B.; Taberner, M.; Melin, F.; Verstraete, M. M.; Widlowski, J.-L.

    2003-04-01

    This paper presents a first and preliminary evaluation of the performance of the algorithm implemented in the Medium Resolution Imaging Spectrometer (MERIS) ground segment for assessing the status of land surfaces. First, we propose an updated version of the MERIS algorithm itself, which improves the accuracy of the product. Second, we analyze the first results by inter-comparing the MERIS Global Vegetation Index (MGVI) to similar products derived from the Sea-viewing Wide Field-of-view Sensor (SeaWiFS) that are generated at the European Commission Joint Research Center (EC-JRC). The first evaluation between MERIS and SeaWiFS derived products is made using data acquired on the same day by both instruments. The results show acceptable agreement and the differences are well understood by radiation transfer model simulations.

  12. APEX 3D Propeller Test Preliminary Design

    NASA Technical Reports Server (NTRS)

    Colozza, Anthony J.

    2002-01-01

    A low Reynolds number, high subsonic mach number flight regime is fairly uncommon in aeronautics. Most flight vehicles do not fly under these aerodynamic conditions. However, recently there have been a number of proposed aircraft applications (such as high altitude observation platforms and Mars aircraft) that require flight within this regime. One of the main obstacles to flight under these conditions is the ability to reliably generate sufficient thrust for the aircraft. For a conventional propulsion system, the operation and design of the propeller is the key aspect to its operation. Due to the difficulty in experimentally modeling the flight conditions in ground-based facilities, it has been proposed to conduct propeller experiments from a high altitude gliding platform (APEX). A preliminary design of a propeller experiment under the low Reynolds number, high mach number flight conditions has been devised. The details of the design are described as well as the potential data that will be collected.

  13. Preliminary assessment of valve IST effectiveness

    SciTech Connect

    Grove, E.; DiBiasio, A.; Carbonaro, J.

    1994-06-01

    A preliminary review of 1ST effectiveness for Code Class 1, 2, and 3 valves at nuclear power plants was performed. These requirements are specified by ASME Section 11, and the Operations and Maintenance Standards (OM-10). The INPO NPRDS database was used to provide failure reports for these components for 1988 to 1992. This time period coincides with the issuance of Generic Letter 89-04, which resulted in a more consistent application of the requirements by the licensees. For this time period, 8593 valve failures were identified. From the review of the NPRDS database, the primary failure causes and failure modes for motor operated (MOV), air operated (AOV), and check valves (CV) were identified. Solenoid operated valves (SOV) were not reviewed in this study. Plant testing programs were effective in identifying approximately 60% of the CV failures, 46% of the AOV failures, and 44% of the MOV failures.

  14. Spacelab payload accommodation handbook. Preliminary issue

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The main characteristics of the Spacelab system are described. Sufficient information on Spacelab capabilities is provided to enable individual experimenters or payload planning groups to determine how their payload equipment can be accomodated by Spacelab topics discussed include major spacelab/experiment interfaces; Spacelab payload support systems and requirements the experiments must comply with to allow experiment design; and development and integration up to a level where a group of individual experiments are integrated into a complete Spacelab payload using Spacelab racks/floors and pallet segments. Integration of a complete Spacelab payload with Spacelab subsystems, primary module structure etc., integration of Spacelab with the Orbiter and basic operational aspects are also covered in this preliminary edition of the handbook which reflects the current Spacelab baseline design and is for information only.

  15. Preliminary microfluidic simulations for immersion lithography

    NASA Astrophysics Data System (ADS)

    Wei, Alexander C.; Nellis, Greg F.; Abdo, Amr Y.; Engelstad, Roxann L.; Chen, Cheng-Fu; Switkes, Michael; Rothschild, Mordechai

    2003-06-01

    The premise behind immersion lithography is to improve the resolution for optical lithography technology by increasing the index of refraction in the space between the final projection lens of an exposure system and the device wafer. This is accomplished through the insertion of a high index liquid in place of the low index air that currently fills the gap. The fluid management system must reliably fill the lens-wafer gap with liquid, maintain the fill under the lens throughout the entire wafer exposure process, and ensure that no bubbles are entrained during filling or scanning. This paper presents a preliminary analysis of the fluid flow characteristics of a liquid between the lens and the wafer in immersion lithography. The objective of this feasibility study was to identify liquid candidates that meet both optical and specific fluid mechanical requirements. The mechanics of the filling process was analyzed to simplify the problem and identify those fluid properties and system parameters that affect the process. Two-dimensional computational fluid dynamics (CFD) models of the fluid between the lens and the wafer were developed for simulating the process. The CFD simulations were used to investigate two methods of liquid deposition. In the first, a liquid is dispensed onto the wafer as a "puddle" and then the wafer and liquid move under the lens. This is referred to as passive filling. The second method involves the use of liquid jets in close proximity to the edge of the lens and is referred to as active filling. Numerical simulations of passive filling included a parametric study of the key dimensionless group influencing the filling process and an investigation of the effects of the fluid/wafer and fluid/lens contact angles and wafer direction. The model results are compared with experimental measurements. For active filling, preliminary simulation results characterized the influence of the jets on fluid flow.

  16. Preliminary dose assessment of the Chernobyl accident

    SciTech Connect

    Hull, A.P.

    1987-01-01

    From the major accident at Unit 4 of the Chernobyl nuclear power station, a plume of airborne radioactive fission products was initially carried northwesterly toward Poland, thence toward Scandinavia and into Central Europe. Reports of the levels of radioactivity in a variety of media and of external radiation levels were collected in the Department of Energy's Emergency Operations Center and compiled into a data bank. Portions of these and other data which were obtained directly from published and official reports were utilized to make a preliminary assessment of the extent and magnitude of the external dose to individuals downwind from Chernobyl. Radioactive /sup 131/I was the predominant fission product. The time of arrival of the plume and the maximum concentrations of /sup 131/I in air, vegetation and milk and the maximum reported depositions and external radiation levels have been tabulated country by country. A large amount of the total activity in the release was apparently carried to a significant elevation. The data suggest that in areas where rainfall occurred, deposition levels were from ten to one-hundred times those observed in nearby ''dry'' locations. Sufficient spectral data were obtained to establish average release fractions and to establish a reference spectra of the other nuclides in the release. Preliminary calculations indicated that the collective dose equivalent to the population in Scandinavia and Central Europe during the first year after the Chernobyl accident would be about 8 x 10/sup 6/ person-rem. From the Soviet report, it appears that a first year population dose of about 2 x 10/sup 7/ person-rem (2 x 10/sup 5/ Sv) will be received by the population who were downwind of Chernobyl within the U.S.S.R. during the accident and its subsequent releases over the following week. 32 refs., 14 figs., 20 tabs.

  17. North Korean refugee doctors' preliminary examination scores

    PubMed Central

    2016-01-01

    Purpose Although there have been studies emphasizing the re-education of North Korean (NK) doctors for post-unification of the Korean Peninsula, study on the content and scope of such re-education has yet to be conducted. Researchers intended to set the content and scope of re-education by a comparative analysis for the scores of the preliminary examination, which is comparable to the Korean Medical Licensing Examination (KMLE). Methods The scores of the first and second preliminary exams were analyzed by subject using the Wilcoxon signed rank test. The passing status of the group of NK doctors for KMLE in recent 3 years were investigated. The multiple-choice-question (MCQ) items of which difficulty indexes of NK doctors were lower than those of South Korean (SK) medical students by two times of the standard deviation of the scores of SK medical students were selected to investigate the relevant reasons. Results The average scores of nearly all subjects were improved in the second exam compared with the first exam. The passing rate of the group of NK doctors was 75%. The number of MCQ items of which difficulty indexes of NK doctors were lower than those of SK medical students was 51 (6.38%). NK doctors’ lack of understandings for Diagnostic Techniques and Procedures, Therapeutics, Prenatal Care, and Managed Care Programs was suggested as the possible reason. Conclusion The education of integrated courses focusing on Diagnostic Techniques and Procedures and Therapeutics, and apprenticeship-style training for clinical practice of core subjects are needed. Special lectures on the Preventive Medicine are likely to be required also. PMID:27907983

  18. NSLS-II Preliminary Design Report

    SciTech Connect

    Dierker, S.

    2007-11-01

    Following the CD0 approval of the National Synchrotron Light Source II (NSLS-II) during August 2005, Brookhaven National Laboratory prepared a conceptual design for a worldclass user facility for scientific research using synchrotron radiation. DOE SC review of the preliminary baseline in December 2006 led to the subsequent CD1 approval (approval of alternative selection and cost range). This report is the documentation of the preliminary design work for the NSLS-II facility. The preliminary design of the Accelerator Systems (Part 1) was developed mostly based of the Conceptual Design Report, except for the Booster design, which was changed from in-storage-ring tunnel configuration to in external- tunnel configuration. The design of beamlines (Part 2) is based on designs developed by engineering firms in accordance with the specification provided by the Project. The conventional facility design (Part 3) is the Title 1 preliminary design by the AE firm that met the NSLS-II requirements. Last and very important, Part 4 documents the ES&H design and considerations related to this preliminary design. The NSLS-II performance goals are motivated by the recognition that major advances in many important technology problems will require scientific breakthroughs in developing new materials with advanced properties. Achieving this will require the development of new tools that will enable the characterization of the atomic and electronic structure, chemical composition, and magnetic properties of materials, at nanoscale resolution. These tools must be nondestructive, to image and characterize buried structures and interfaces, and they must operate in a wide range of temperatures and harsh environments. The NSLS-II facility will provide ultra high brightness and flux and exceptional beam stability. It will also provide advanced insertion devices, optics, detectors, and robotics, and a suite of scientific instruments designed to maximize the scientific output of the facility

  19. Preliminary results of steel containment vessel model test

    SciTech Connect

    Luk, V.K.; Hessheimer, M.F.; Matsumoto, T.; Komine, K.; Arai, S.; Costello, J.F.

    1998-04-01

    A high pressure test of a mixed-scaled model (1:10 in geometry and 1:4 in shell thickness) of a steel containment vessel (SCV), representing an improved boiling water reactor (BWR) Mark II containment, was conducted on December 11--12, 1996 at Sandia National Laboratories. This paper describes the preliminary results of the high pressure test. In addition, the preliminary post-test measurement data and the preliminary comparison of test data with pretest analysis predictions are also presented.

  20. The role of NASTRAN in the preliminary design cycle

    NASA Technical Reports Server (NTRS)

    Grooms, H. R.; Baipsys, V. J.

    1993-01-01

    This paper explains how NASTRAN can be utilized advantageously in the preliminary design cycle. The initial portion of the preliminary design process lends itself to programs that can produce multiple configurations or variations on a particular design with minimal cost or effort. The latter portion of the process encompasses refining the design and adding more detailed analyses (particularly for other disciplines). A method for quickly generating balanced spacecraft loading conditions for use in preliminary design and analysis also is explained. The following additional sections are included: Background, Symbols, Analytical Process, Aerodynamic Load Distributions, NASTRAN Applications, Conclusion and References.

  1. Astor Pass Seismic Surveys Preliminary Report

    SciTech Connect

    Louie, John; Pullammanappallil, Satish; Faulds, James; Eisses, Amy; Kell, Annie; Frary, Roxanna; Kent, Graham

    2011-08-05

    In collaboration with the Pyramid Lake Paiute Tribe (PLPT), the University of Nevada, Reno (UNR) and Optim re-processed, or collected and processed, over 24 miles of 2d seismic-reflection data near the northwest corner of Pyramid Lake, Nevada. The network of 2d land surveys achieved a near-3d density at the Astor Pass geothermal prospect that the PLPT drilled during Nov. 2010 to Feb. 2011. The Bureau of Indian Affairs funded additional seismic work around the Lake, and an extensive, detailed single-channel marine survey producing more than 300 miles of section, imaging more than 120 ft below the Lake bottom. Optim’s land data collection utilized multiple heavy vibrators and recorded over 200 channels live, providing a state-of-the-art reflection-refraction data set. After advanced seismic analysis including first-arrival velocity optimization and prestack depth migration, the 2d sections show clear fault-plane reflections, in some areas as deep as 4000 ft, tying to distinct terminations of the mostly volcanic stratigraphy. Some lines achieved velocity control to 3000 ft depth; all lines show reflections and terminations to 5000 ft depth. Three separate sets of normal faults appear in an initial interpretation of fault reflections and stratigraphic terminations, after loading the data into the OpendTect 3d seismic visualization system. Each preliminary fault set includes a continuous trace more than 3000 ft long, and a swarm of short fault strands. The three preliminary normal-fault sets strike northerly with westward dip, northwesterly with northeast dip, and easterly with north dip. An intersection of all three fault systems documented in the seismic sections at the end of Phase I helped to locate the APS-2 and APS-3 slimholes. The seismic sections do not show the faults connected to the Astor Pass tufa spire, suggesting that we have imaged mostly Tertiary-aged faults. We hypothesize that the Recent, active faults that produced the tufa through hotspring

  2. Preliminary Framework for Human-Automation Collaboration

    SciTech Connect

    Oxstrand, Johanna Helene; Le Blanc, Katya Lee; Spielman, Zachary Alexander

    2015-09-01

    The Department of Energy’s Advanced Reactor Technologies Program sponsors research, development and deployment activities through its Next Generation Nuclear Plant, Advanced Reactor Concepts, and Advanced Small Modular Reactor (aSMR) Programs to promote safety, technical, economical, and environmental advancements of innovative Generation IV nuclear energy technologies. The Human Automation Collaboration (HAC) Research Project is located under the aSMR Program, which identifies developing advanced instrumentation and controls and human-machine interfaces as one of four key research areas. It is expected that the new nuclear power plant designs will employ technology significantly more advanced than the analog systems in the existing reactor fleet as well as utilizing automation to a greater extent. Moving towards more advanced technology and more automation does not necessary imply more efficient and safer operation of the plant. Instead, a number of concerns about how these technologies will affect human performance and the overall safety of the plant need to be addressed. More specifically, it is important to investigate how the operator and the automation work as a team to ensure effective and safe plant operation, also known as the human-automation collaboration (HAC). The focus of the HAC research is to understand how various characteristics of automation (such as its reliability, processes, and modes) effect an operator’s use and awareness of plant conditions. In other words, the research team investigates how to best design the collaboration between the operators and the automated systems in a manner that has the greatest positive impact on overall plant performance and reliability. This report addresses the Department of Energy milestone M4AT-15IN2302054, Complete Preliminary Framework for Human-Automation Collaboration, by discussing the two phased development of a preliminary HAC framework. The framework developed in the first phase was used as the

  3. Mars Express Bistatic Radar: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Simpson, R. A.; Tyler, G. L.; Paetzold, M.

    2005-08-01

    Bistatic radar, conducted at microwave frequencies, can be a convenient and cost-effective method for probing planetary surfaces at centimeter scales - dimensions of interest in selecting lander and rover sites, for example. Half a dozen such experiments have been conducted using Mars Express in a new mode, which relies on relative echo strengths in two orthogonal polarizations rather than absolute calibration of a single polarization (see Simpson and Tyler, ICARUS 152, pp 70-74, 2001). Observations conducted to date have been limited to a fixed spacecraft attitude (inertial pointing); so dielectric constant estimates are valid at only one specular point per wavelength per experiment. Preliminary results have been obtained for Vastitas Borealis (64.1N, 60.1E), the southeast rim of Argyre (56.0S, 324.8E), and plains west of Argyre (51.0S, 289.4E). Dielectric constants are N/A and 2.7, 2.0 and 2.1, and 3.2 and 3.5 at the three sites at 3.5 and 13.1 cm wavelengths, respectively. These confirm spatial variability (while being within the nominal range for Mars) and show the expected lower values at shorter wavelengths.

  4. Preliminary evaluation of implantable MOSFET radiation dosimeters.

    PubMed

    Beddar, A S; Salehpour, M; Briere, T M; Hamidian, H; Gillin, M T

    2005-01-07

    In this paper, we report on measurements performed on a new prototype implantable radiation detector that uses metal-oxide semiconductor field effect transistors (MOSFETs) designed for in vivo dosimetry. The dosimeters, which are encapsulated in hermetically sealed glass cylinders, are used in an unbiased mode during irradiation, unlike other MOSFET detectors previously used in radiotherapy applications. They are powered by radio frequency telemetry for dose measurements, obviating the need for a power supply within each capsule. We have studied the dosimetric characteristics of these MOSFET detectors in vitro under irradiation from a 60Co source. The detectors show a dose reproducibility generally within 5% or better, with the main sources of error being temperature fluctuations occurring between the pre- and post-irradiation measurements as well as detector orientation. A better temperature-controlled environment leads to a reproducibility within 2%. Our preliminary in vitro results show clearly that true non-invasive in vivo dosimetry measurements are feasible and can be performed remotely using telemetric technology.

  5. Preliminary conceptual design about the CEPC calorimeters

    NASA Astrophysics Data System (ADS)

    Yang, Haijun

    2016-11-01

    The Circular Electron Positron Collider (CEPC) as a Higgs factory was proposed in September 2013. The preliminary conceptual design report was completed in 2015.1 The CEPC detector design was using International Linear Collider Detector — ILD2 as an initial baseline. The CEPC calorimeters, including the high granularity electromagnetic calorimeter (ECAL) and the hadron calorimeter (HCAL), are designed for precise energy measurements of electrons, photons, taus and hadronic jets. The basic resolution requirements for the ECAL and HCAL are about 16%E (GeV) and 50%E (GeV), respectively. To fully exploit the physics potential of the Higgs, W, Z and related Standard Model processes, the jet energy resolution is required to reach 3%-4%, or 30%/E (GeV) at energies below about 100 GeV. To achieve the required performance, a Particle Flow Algorithm (PFA) — oriented calorimetry system is being considered as the baseline design. The CEPC ECAL detector options include silicon-tungsten or scintillator-tungsten structures with analog readout, while the HCAL detector options have scintillator or gaseous detector as the active sensor and iron as the absorber. Some latest R&D studies about ECAL and HCAL within the CEPC working group is also presented.

  6. Preliminary Results of the MARE Experiment

    NASA Astrophysics Data System (ADS)

    Ferri, E.; Bagliani, D.; Biassotti, M.; Ceruti, G.; Corsini, D.; Faverzani, M.; Gatti, F.; Giachero, A.; Gotti, C.; Kilbourne, C.; Kling, A.; Kraft-Bermuth, S.; Maino, M.; Manfrinetti, P.; Nucciotti, A.; Pessina, G.; Pizzigoni, G.; Ribeiro Gomes, M.; Schaeffer, D.; Sisti, M.

    2014-09-01

    The microcalorimeter array for a rhenium experiment (MARE) project aims at the direct and calorimetric measurement of the electron neutrino mass with sub-eV sensitivity. The design is based on large arrays of thermal detectors to study the beta decay of Re and the electron capture of Ho. One of the activities of the project, MARE 1 in Milan, has started in Milan using one array of 6 6 silicon implanted thermistors equipped with AgReO absorbers. The purposes of MARE 1 in Milan are to achieve a sensitivity on the neutrino mass of a few eV and to investigate the systematics of Re neutrino mass measurements, focusing on those caused by the beta environmental fine structure and the beta spectrum theoretical shape. In parallel, the MARE collaboration is performing an R&D work for producing absorbers embedded with radioactive metal Ho. We report here the status of MARE using Re as beta source and the preliminary results obtained with Ho.

  7. STACEE-32: Design, performance, and preliminary results

    NASA Astrophysics Data System (ADS)

    Ong, Rene A.

    2000-06-01

    The Solar Tower Atmospheric Cherenkov Effect Experiment (STACEE) is designed to detect astrophysical sources of γ-rays at energies between 25 and 500 GeV. STACEE uses large solar mirrors (heliostats) to collect the atmospheric Cherenkov radiation produced in γ-ray air showers. The use of a large mirror collection area will allow STACEE to probe γ-ray sources at energies above the reach of the Compton Gamma Ray Observatory (CGRO), but below the reach of conventional Cherenkov telescopes. During the 1998-99 observing season, a portion of STACEE using 32 heliostats was installed at the National Solar Thermal Test Facility (NSTTF) of Sandia National Laboratories (Albuquerque, NM). This initial configuration (STACEE-32) observed a number of astronomical sources, including the Crab and several active galactic nuclei (AGN). Here we report on these observations. We highlight the experimental configuration and the preliminary results from the Crab data. The full STACEE experiment using 64 heliostats will be commissioned in 2000. .

  8. Preliminary results from an advanced lighting controlstestbed

    SciTech Connect

    Avery, Douglas; Jennings, Judity; Rubinstein, Francis

    1998-03-01

    Preliminary results from a large-scale testbed of advanced lighting control technologies at the Phillip Burton Federal Building at 450 Golden Gate Ave. in San Francisco are presented. The first year objective of this project is to determine the sustainable energy savings and cost-effectiveness of different lighting control technologies compared to a portion of the building where only minimal controls are installed. The paper presents the analyzed results from six months of tests focused on accurately characterizing the energy savings potential of one type of daylight-linked lighting controls compared to the lighting in similar open-planned areas without dimming controls. After analyzing a half year;s data, we determined that the annual energy savings for this type of daylight- linked controls was 41% and 30% for the outer rows of lights on the South and North sides of the building, respectively. The annual energy savings dropped to 22% and 16% for the second row of lights for the South and North, respectively, and was negligible for the third rows of lights.

  9. Preliminary floor, seat, and dummy data

    NASA Technical Reports Server (NTRS)

    Cannon, M. R.; Zimmerman, R. E.

    1986-01-01

    According to preliminary examination of the data, out of 179 data channels that were onboard the aircraft in support of the seat experiments, there is data from 168. There was somewhat more severe environment imposed in the structure of the obstacles than by the ground impact. Therefore, both ground impact and obstacle impact are of interest for crashworthiness experiments. Most of the data channels that were studied are fairly consistent with the physical evidence: they show acceleration levels that are reasonable, and in many cases these integrate out to a reasonable velocity change. Finally, from observation thus far, the ground impact did not fail or significantly damage any seat. Nor did any of the energy absorbers in the modified seats extend. The accelerations do not appear high enough and/or energetic enough to cause this to happen. At this time, the onboard films have not been studied; only some videotape have been viewed. Some of the seats were so badly damaged by the fire that any failures which might have occurred were obscured. A close examination of the onboard films using a stop-action projector will allow a more thorough evaluation.

  10. Preliminary test results for the SVX4

    SciTech Connect

    Christofek, L.; Hanagaki, K.; Rapidis, P.; Utes, M.; /Fermilab

    2005-06-01

    We present and summarize the preliminary test results for SVX4 chip testing. There are presently two versions of the SVX4. Version 2 has on-chip bypassing and Version 1 does not. The on-chip bypassing is a layer of transistors under the front-end analog pipeline that acts as a bypassing capacitor for the voltage supply. Its size is about a microfarad. We aggressively choose to test Version 2 because of this feature. The feature is advantageous for hybrid design because it eliminates the need for an additional passive component on the hybrid itself by placing it on the actual SVX4 die. Also, the SVX4 was designed to operate in two modes: D. and CDF. One can set which mode the chip will operate by placing a jumper in the proper position on the SVX4 chip carrier. In either mode, the chip can either use the operating parameters from the shift register or the shadow register. Similarly, this is selected by placing a jumper on the SVX4 chip carrier. This chip has this feature because it was unknown whether the new design of the shadow register would be operable. The shadow register is also call the SEU register or Single Event Upset register. An introduction into the functionality of the chip and an explanation on the difference between D. and CDF mode can be found in the SVX4 User's Manual [1].

  11. Preliminary High-Throughput Metagenome Assembly

    SciTech Connect

    Dusheyko, Serge; Furman, Craig; Pangilinan, Jasmyn; Shapiro, Harris; Tu, Hank

    2007-03-26

    Metagenome data sets present a qualitatively different assembly problem than traditional single-organism whole-genome shotgun (WGS) assembly. The unique aspects of such projects include the presence of a potentially large number of distinct organisms and their representation in the data set at widely different fractions. In addition, multiple closely related strains could be present, which would be difficult to assemble separately. Failure to take these issues into account can result in poor assemblies that either jumble together different strains or which fail to yield useful results. The DOE Joint Genome Institute has sequenced a number of metagenomic projects and plans to considerably increase this number in the coming year. As a result, the JGI has a need for high-throughput tools and techniques for handling metagenome projects. We present the techniques developed to handle metagenome assemblies in a high-throughput environment. This includes a streamlined assembly wrapper, based on the JGI?s in-house WGS assembler, Jazz. It also includes the selection of sensible defaults targeted for metagenome data sets, as well as quality control automation for cleaning up the raw results. While analysis is ongoing, we will discuss preliminary assessments of the quality of the assembly results (http://fames.jgi-psf.org).

  12. Guidance for performing preliminary assessments under CERCLA

    SciTech Connect

    1991-09-01

    EPA headquarters and a national site assessment workgroup produced this guidance for Regional, State, and contractor staff who manage or perform preliminary assessments (PAs). EPA has focused this guidance on the types of sites and site conditions most commonly encountered. The PA approach described in this guidance is generally applicable to a wide variety of sites. However, because of the variability among sites, the amount of information available, and the level of investigative effort required, it is not possible to provide guidance that is equally applicable to all sites. PA investigators should recognize this and be aware that variation from this guidance may be necessary for some sites, particularly for PAs performed at Federal facilities, PAs conducted under EPA`s Environmental Priorities Initiative (EPI), and PAs at sites that have previously been extensively investigated by EPA or others. The purpose of this guidance is to provide instructions for conducting a PA and reporting results. This guidance discusses the information required to evaluate a site and how to obtain it, how to score a site, and reporting requirements. This document also provides guidelines and instruction on PA evaluation, scoring, and the use of standard PA scoresheets. The overall goal of this guidance is to assist PA investigators in conducting high-quality assessments that result in correct site screening or further action recommendations on a nationally consistent basis.

  13. Preliminary design of turbopumps and related machinery

    NASA Technical Reports Server (NTRS)

    Wislicenus, George F.

    1986-01-01

    Pumps used in large liquid-fuel rocket engines are examined. The term preliminary design denotes the initial, creative phases of design, where the general shape and characteristics of the machine are determined. This compendium is intended to provide the design engineer responsible for these initial phases with a physical understanding and background knowledge of the numerous special fields involved in the design process. Primary attention is directed to the pumping part of the turbopump and hence is concerned with essentially incompressible fluids. However, compressible flow principles are developed. As much as possible, the simplicity and reliability of incompressible flow considerations are retained by treating the mechanics of compressible fluids as a departure from the theory of incompressible fluids. Five areas are discussed: a survey of the field of turbomachinery in dimensionless form; the theoretical principles of the hydrodynamic design of turbomachinery; the hydrodynamic and gas dynamic design of axial flow turbomachinery; the hydrodynamic and gas dynamic design of radial and mixed flow turbomachinery; and some mechanical design considerations of turbomachinery. Theoretical considerations are presented with a relatively elementary mathematical treatment.

  14. Preliminary experience with monoenergetic photon mammography

    SciTech Connect

    Johnston, R.E.; Washburn, D.; Pisano, E.; Thomlinson, W.C.; Chapman, D.; Gmur, N.F.; Zhong, Zhong; Sayers, D.

    1995-12-31

    We are using a beam port at the National Synchrotron Light Source facility at Brookhaven National Laboratory as a source of monoenergetic photons. The photon source is radiation from a bending magnet on the X-ray storage ring and provides a usable X-ray spectrum from 5 keV to over 50 keV. A tunable crystal monochromotor is used for energy selection. The beam is 79mm wide and 0.5 mm high. We imaged the ACR mammography phantom and a contrast-detail phantom using a phosphor plate as the unaging detector. Phantom images were obtained at 16, 18, 20 and 22 keV. Phantom thickness varied from 15 mm to 82 mm. These images were compared to images obtained with a conventional dedicated mammography unit. Subjective preliminary results show that image contrast of the monoenergetic images is similar to those obtained from the conventional x-ray source with somewhat sharper and cleaner images from the monoenergetic source. Quantitative analysis shows that the monoenergetic images have improved contrast compared to the polyenergetic derived images. Entrance skin dose measurements show a factor of 5 to 10 times less radiation for the monoenergetic images with equivalent or better contrast Although there remain a number of technical problems to be addressed and much more work to be done, we are encouraged to further explore the use of monoenergetic imaging.

  15. Preliminary assessment of pump IST effectiveness

    SciTech Connect

    DiBiasio, A.; Grove, E.; Carbonaro, J.

    1994-06-01

    A preliminary review of Inservice Testing (IST) effectiveness for Code Class 1, 2, and 3 pumps at nuclear power plants was performed. IST requirements are specified by ASME Section XI, and the Operations and Maintenance Standard (OM Part 6). The INPO NPRDS database was used to provide failure reports for these components for 1988 to 1992. This time frame coincides with the issuance of Generic Letter 89-04, which resulted in a more consistent application of the requirements by the licensees. For this time period, 2585 pump failures were reported. A review of these failures indicated that the majority (71.6%) were due to external leakage, and were excluded from this study since these events typically do not affect pump operability and are not detected by the measurement of IST parameters. Of the remaining 733 events, a review was performed to identify the primary failure causes, failure modes, and method of detection. Plant testing programs, consisting of IST, surveillance testing, and special testing, detected approximately 40% of these occurrences. Others were detected through operational abnormalities, routine and incidental observations, alarms, and while performing maintenance. This paper provides a discussion of the results of the study.

  16. Cockpit task management: A preliminary, normative theory

    NASA Technical Reports Server (NTRS)

    Funk, Ken

    1991-01-01

    Cockpit task management (CTM) involves the initiation, monitoring, prioritizing, and allocation of resources to concurrent tasks as well as termination of multiple concurrent tasks. As aircrews have more tasks to attend to due to reduced crew sizes and the increased complexity of aircraft and the air transportation system, CTM will become a more critical factor in aviation safety. It is clear that many aviation accidents and incidents can be satisfactorily explained in terms of CTM errors, and it is likely that more accidents induced by poor CTM practice will occur in the future unless the issue is properly addressed. The first step in understanding and facilitating CTM behavior was the development of a preliminary, normative theory of CTM which identifies several important CTM functions. From this theory, some requirements for pilot-vehicle interfaces were developed which are believed to facilitate CTM. A prototype PVI was developed which improves CTM performance and currently, a research program is under way that is aimed at developing a better understanding of CTM and facilitating CTM performance through better equipment and procedures.

  17. PRELIMINARY SELECTION OF MGR DESIGN BASIS EVENTS

    SciTech Connect

    J.A. Kappes

    1999-09-16

    The purpose of this analysis is to identify the preliminary design basis events (DBEs) for consideration in the design of the Monitored Geologic Repository (MGR). For external events and natural phenomena (e.g., earthquake), the objective is to identify those initiating events that the MGR will be designed to withstand. Design criteria will ensure that radiological release scenarios resulting from these initiating events are beyond design basis (i.e., have a scenario frequency less than once per million years). For internal (i.e., human-induced and random equipment failures) events, the objective is to identify credible event sequences that result in bounding radiological releases. These sequences will be used to establish the design basis criteria for MGR structures, systems, and components (SSCs) design basis criteria in order to prevent or mitigate radiological releases. The safety strategy presented in this analysis for preventing or mitigating DBEs is based on the preclosure safety strategy outlined in ''Strategy to Mitigate Preclosure Offsite Exposure'' (CRWMS M&O 1998f). DBE analysis is necessary to provide feedback and requirements to the design process, and also to demonstrate compliance with proposed 10 CFR 63 (Dyer 1999b) requirements. DBE analysis is also required to identify and classify the SSCs that are important to safety (ITS).

  18. Preliminary analysis of regional-precipitation periodicity

    USGS Publications Warehouse

    Perry, Charles A.

    1980-01-01

    Precipitation variability plays a major role in nearly every aspect of the hydrologic cycle. Precipitation is not a random event, but it occurs after a sequence of prerequisites has been fulfilled. Recent investigations have shown that activity of the sun can affect atmospheric vorticity, an important factor in precipitation formation. Solar activity is known to be periodic; therefore, through a complex series of physical processes, precipitation variance is solar forced to a certain degree. A preliminary analysis of precipitation periodicity was made for eight regions scattered across the central United States. Each region contained 5 to 10 stations with long-term precipitation records that were averaged to obtain yearly regional-precipitation values. Graphic analysis shows 11-year and 22-year cycles that are nearly in phase with the solar cycles. An example of the effect of cyclic precipitation is presented for the Powder River basin in Wyoming and Montana. A cycle of 22 years exhibits fluctuations of approximately 22 to 27% for precipitation and 38 to 50% for runoff. A more detailed study that investigates solar-forced precipitation cycles and their relationship to hydrologic processes is needed. (USGS)

  19. Preliminary flight prototype potable water bactericide system

    NASA Technical Reports Server (NTRS)

    Jasionowski, W. J.; Allen, E. T.

    1973-01-01

    The development, design, and testing of a preliminary flight prototype potable water bactericide system are described. The system is an assembly of upgraded canisters composed of: (1) A biological filter; (2) an activated charcoal and ion exchange resin canister; (3) a silver chloride canister, (4) a deionizer, (5) a silver bromide canister with a partial bypass, and (6) mock-up instrumentation and circuitry. The system exhibited bactericidal activity against 10 to the 9th power Pseudomonas aeruginosa and/or Type IIIa, and reduced Bacillus subtilis by up to 5 orders of magnitude in 24 hours at ambient temperatures with a 1 ppm silver ion dose. Four efficacy tests were performed with a AgBr canister dosing anticipated fuel cell water. Tests show that a 0.05 ppm silver ion dose was bactericidal against 3 plus or minus 1 x 10 to the 9th power (5 plus or minus 1 x 10,000/ml Pseudomonas aeruginosa and/or Type IIIa in 15 minutes or less.

  20. Overweight and urban pollution: preliminary results.

    PubMed

    Ponticiello, Barnaba Giuseppina; Capozzella, Assunta; Di Giorgio, Valeria; Casale, Teodorico; Giubilati, Roberto; Tomei, Gianfranco; Tomei, Francesco; Rosati, Maria Valeria; Sancini, Angela

    2015-06-15

    The aim of this study is to determine whether in workers exposed to urban pollution the risk of developing overweight and obesity is higher in workers exposed to urban pollution compared to a control group. The study was conducted on 150 volunteers, 75 workers exposed to urban pollution (50 women and 25 men) and 75 indoor workers (50 women and 25 men). Once measured the weight and height and calculated body mass index (BMI) for each worker, the research was based on the comparison, between the two groups, of the mean values of the measurements and of the frequency of workers with BMI index higher than the cut-off of normality. The only statistically significant difference found was for the mean value of weight in women, which was higher among outdoor workers compared to indoor workers. The mean values of BMI and the frequency of workers with BMI higher than normal was higher among outdoor workers compared to indoor workers in both sexes, but not statistically significant. The data suggest that outdoor workers may be subject to an additional risk of developing obesity as a result of exposure to urban air pollution (which, like obesity, is a source of oxidative stress). So, our preliminary study encourages to continue this line of research by implementing the sample and considering all the confounding factors. Furthermore, the results highlight the necessity to take account of gender differences in the context of health surveillance of workers.

  1. Global precipitation measurement (GPM) preliminary design

    NASA Astrophysics Data System (ADS)

    Neeck, Steven P.; Kakar, Ramesh K.; Azarbarzin, Ardeshir A.; Hou, Arthur Y.

    2008-10-01

    The overarching Earth science mission objective of the Global Precipitation Measurement (GPM) mission is to develop a scientific understanding of the Earth system and its response to natural and human-induced changes. This will enable improved prediction of climate, weather, and natural hazards for present and future generations. The specific scientific objectives of GPM are advancing: Precipitation Measurement through combined use of active and passive remote-sensing techniques, Water/Energy Cycle Variability through improved knowledge of the global water/energy cycle and fresh water availability, Climate Prediction through better understanding of surface water fluxes, soil moisture storage, cloud/precipitation microphysics and latent heat release, Weather Prediction through improved numerical weather prediction (NWP) skills from more accurate and frequent measurements of instantaneous rain rates with better error characterizations and improved assimilation methods, Hydrometeorological Prediction through better temporal sampling and spatial coverage of highresolution precipitation measurements and innovative hydro-meteorological modeling. GPM is a joint initiative with the Japan Aerospace Exploration Agency (JAXA) and other international partners and is the backbone of the Committee on Earth Observation Satellites (CEOS) Precipitation Constellation. It will unify and improve global precipitation measurements from a constellation of dedicated and operational active/passive microwave sensors. GPM is completing the Preliminary Design Phase and is advancing towards launch in 2013 and 2014.

  2. Preliminary DMR measurements of the CMB isotropy

    NASA Technical Reports Server (NTRS)

    Smoot, G. F.; Bennett, C. L.; Kogut, A.; Aymon, J.; Backus, C.; De Amici, G.; Galuk, K.; Jackson, P. D.; Keegstra, P.; Rokke, L.

    1991-01-01

    The COBE Differential Microwave Radiometers (DMR) instrument has produced preliminary full-sky maps at frequencies 31.5, 53, and 90 GHz. The redundant channels and matched beams at three frequencies distinguish the DMR from previous large-scale surveys. Galactic emission is seen unambiguously at all three frequencies. The only large-scale anisotropy detected in the cosmic microwave background is the dipole anisotropy. There is no clear evidence for any other large-angular-scale feature in the maps. Without correcting for any systematic effects, we are able to place limits DeltaT/T sub 0 less than 3 x 10 exp -5 for the rms quadrupole amplitude, DeltaT/T sub 0 less than 4 x 10 exp -5 for monochromatic fluctuations, and DeltaT/T sub 0 less than 4 x 10 exp -5 for Gaussian fluctuations (all limits are 95 percent C.L. with TO = 2.735 K). The data limit DeltaT/T sub 0 less than 10 exp -4 for any feature larger than 7 deg. We briefly review the DMR and discuss some implications of these results in cosmology.

  3. Preliminary Results from the Lunar Prospector Alpha Particle Spectrometer

    NASA Astrophysics Data System (ADS)

    Lawson, S. L.; Feldman, W. C.; Moore, K. R.; Lawrence, D. J.; Maurice, S.; Belian, R. D.; Binder, A. B.

    2001-03-01

    Data measured using the Lunar Prospector Alpha Particle Spectrometer were surveyed to search for surface deposits of polonium-210. Preliminary results show that a marginal, yet statistically-significant signal was indeed detected on the lunar front side.

  4. Space telescope observatory management system preliminary test and verification plan

    NASA Technical Reports Server (NTRS)

    Fritz, J. S.; Kaldenbach, C. F.; Williams, W. B.

    1982-01-01

    The preliminary plan for the Space Telescope Observatory Management System Test and Verification (TAV) is provided. Methodology, test scenarios, test plans and procedure formats, schedules, and the TAV organization are included. Supporting information is provided.

  5. Preliminary basic performance analysis of the Cedar multiprocessor memory system

    NASA Technical Reports Server (NTRS)

    Gallivan, K.; Jalby, W.; Turner, S.; Veidenbaum, A.; Wijshoff, H.

    1991-01-01

    Some preliminary basic results on the performance of the Cedar multiprocessor memory system are presented. Empirical results are presented and used to calibrate a memory system simulator which is then used to discuss the scalability of the system.

  6. EURO-CARES Sample Curation Facility: Preliminary Design

    NASA Astrophysics Data System (ADS)

    Hutzler, A.; Ferrière, L.; Bennett, A.; Brucato, J. R.; Debaille, V.; Folco, L.; Longobardo, A.; Meneghin, A.; Palomba, E.; Pottage, T.; Smith, C. L.; Euro-Cares Consortium

    2016-08-01

    EURO-CARES is a multinational project, funded under the European Commission's Horizon2020 research programme to create a roadmap of a European Extra-terrestrial Sample Curation Facility. We present here a preliminary design of the facility.

  7. 33. Historic American Buildings Survey COPY OF PRELIMINARY STUDY FOR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    33. Historic American Buildings Survey COPY OF PRELIMINARY STUDY FOR HEALY BUILDING, c. 1876 (COURTESY OF THE COMMISSION OF FINE ARTS) - Georgetown University, Healy Building, Thirty-seventh & O Streets, Northwest, Washington, District of Columbia, DC

  8. Wrinkle Ridges in Aeolis Dorsa, Mars: Preliminary Mapping

    NASA Astrophysics Data System (ADS)

    Borden, R. M.; Burr, D. M.

    2016-06-01

    Previous work has interpreted wrinkle ridges as compressional landforms caused by movement along blind thrust faults. Our preliminary mapping in the Aeolis Dorsa, Mars has identified widely distributed wrinkle ridges, suggesting episodic contraction.

  9. Preliminary design activities for solar heating and cooling systems

    NASA Technical Reports Server (NTRS)

    1978-01-01

    Information on the development of solar heating and cooling systems is presented. The major emphasis is placed on program organization, system size definition, site identification, system approaches, heat pump and equipment design, collector procurement, and other preliminary design activities.

  10. Production and preliminary testing of multianalyte imaging sensor arrays

    SciTech Connect

    Richards, J.B.; Brown, S.B.; Milanovich, F.P.; Healey, B.G.; Chadha, S.; Walt, D.R.

    1994-11-01

    This report covers the production and preliminary testing of fiber optic sensors that contain a discrete array of analyte specific sensors on their distal ends. The development of the chemistries associated with this technology is covered elsewhere.

  11. Notification: Preliminary Research on Various Administrative Areas (reissued)

    EPA Pesticide Factsheets

    September 11, 2013. The U.S. Environmental Protection Agency’s Office of Inspector General plans to begin preliminary research on various administrative areas as a result of recent actions taken against a former EPA employee.

  12. Preliminary design package for prototype solar heating system

    NASA Technical Reports Server (NTRS)

    1976-01-01

    A preliminary design review on the development of a prototype solar heating system for single family dwellings is presented. The collector, storage, transport, control, and site data acquisition subsystems are described.

  13. Preliminary Examination of the Interstellar Collector of Stardust

    NASA Astrophysics Data System (ADS)

    Westphal, A. J.; Allen, C. C.; Bastien, R.; Borg, J.; Brenker, F.; Bridges, J. C.; Brownlee, D. E.; Butterworth, A. L.; Floss, C.; Flynn, G. J.; Frank, D.; Gainsforth, Z.; Gruen, E.; Hoppe, P.; Kearsley, A. T.; Leroux, H.; Nittler, L. R.; Sandford, S. A.

    2008-03-01

    We describe the Stardust Interstellar Preliminary Examination (ISPE), which will use non-destructive, non-invasive techniques to identify and characterize candidate interstellar impacts in the Stardust aerogel and foil collectors.

  14. Preliminary safety information document for the standard MHTGR: Volume 3

    SciTech Connect

    1986-01-01

    This report presents preliminary safety information for the standard MHTGR. Topics discussed include: plant protection, instrumentation, and control; electrical systems; service systems; and steam and energy conversion systems. (JDB)

  15. 40 CFR 154.31 - Notices of Preliminary Determination.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of whether any changes in the composition, packaging, labeling, or restrictions on use of a pesticide... Special Review. (c) Publication. The Agency shall issue the Notice of Preliminary Determination...

  16. Human-Robot Emergency Response - Experimental Platform and Preliminary Dataset

    DTIC Science & Technology

    2014-07-28

    Human -Robot Emergency Response - Experimental Platform and Preliminary Dataset Technical Report #UM-CS-2014-006 Hee-Tae Jung, Takeshi Takahashi,and...2014 Abstract This paper presents progress towards a research infrastructure for studying human -robot performance in laboratory emergency response...scenarios and a preliminary dataset. It incorporates an emergency response team that is composed of a human participant, n ≤ 4 vision sensors in a

  17. Cast Aluminum Structures Technology (CAST). Phase I. Preliminary Design

    DTIC Science & Technology

    1977-05-01

    49 26 Assumed Crack Growth Rate -- A357 . . . . . . . . . .. 50 27 Flaw Growth at Hole of Gear Attachment Point .... .... 52 28 A357 S-N...wo TABLES Number ?Ile 1 Statistics on.16 Classes of A357 Aluminum Casting Data .. 14 2 "CAST" Preliminary Design Allowables .. .. .. ....... 20 3...damage tolerance criteria; development of preliminary design allowables data for A357 aluminum casting alloy to be used for design until completion

  18. Preliminary design package for prototype solar heating system

    NASA Technical Reports Server (NTRS)

    1978-01-01

    A summary is given of the preliminary analysis and design activity on solar heating systems. The analysis was made without site specific data other than weather; therefore, the results indicate performance expected under these special conditions. Major items include system candidates, design approaches, trade studies and other special data required to evaluate the preliminary analysis and design. The program calls for the development and delivery of eight prototype solar heating and cooling systems for installation and operational test.

  19. Preliminary design studies of an advanced general aviation aircraft

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Preliminary design studies are presented for an advanced general aviation aircraft. Advanced guidance and display concepts, laminar flow, smart structures, fuselage and wing structural design and manufacturing, and preliminary configuration design are discussed. This project was conducted as a graduate level design class under the auspices of the KU/NASA/USRA Advanced Design Program in Aeronautics. The results obtained during the fall semester of 1990 (Phase 1) and the spring semester of 1991 (Phase 2) are presented.

  20. Preliminary status of the CALET observations

    NASA Astrophysics Data System (ADS)

    Torii, Shoji

    2016-07-01

    The CALorimetric Electron Telescope (CALET) space experiment, which has been developed by Japan in collaboration with Italy and the United States, is a high-energy astroparticle physics mission to be installed on the International Space Station (ISS). The primary goals of the CALET mission include investigating possible nearby sources of high energy electrons, studying the details of galactic particle propagation and searching for dark matter signatures. During a two- year mission, extendable to five years, the CALET experiment will measure the flux of cosmic-ray electrons (including positrons) to 20 TeV, gamma-rays to 10 TeV and nuclei with Z=1 to 40 up to several 100 TeV. The instrument consists of two layers of segmented plastic scintillators for the cosmic-ray charge identification (CHD), a 3 radiation length thick tungsten-scintillating fiber imaging calorimeter (IMC) and a 27 radiation length thick lead-tungstate calorimeter (TASC). CALET has sufficient depth, imaging capabilities and excellent energy resolution to allow for a clear separation between hadrons and electrons and between charged particles and gamma rays. The instrument was launched on Aug. 19, 2015 to the ISS with HTV-5 (H-II Transfer Vehicle 5) and was successfully berthed to the Japanese Experiment Module- Exposure Facility (JEM-EF) . After a functional check-out phase until the beginning of October, it started an initial operation phase which was completed on Nov. 17, whence it began its standard operation phase. This paper will review the preliminary status of the CALET.