A Module Experimental Process System Development Unit (MEPSDU)

NASA Technical Reports Server (NTRS)

1981-01-01

The purpose of this program is to demonstrate the technical readiness of a cost effective process sequence that has the potential for the production of flat plate photovoltaic modules which met the price goal in 1986 of $.70 or less per watt peak. Program efforts included: preliminary design review, preliminary cell fabrication using the proposed process sequence, verification of sandblasting back cleanup, study of resist parameters, evaluation of pull strength of the proposed metallization, measurement of contact resistance of Electroless Ni contacts, optimization of process parameter, design of the MEPSDU module, identification and testing of insulator tapes, development of a lamination process sequence, identification, discussions, demonstrations and visits with candidate equipment vendors, evaluation of proposals for tabbing and stringing machine.

Vocal fold tissue failure: preliminary data and constitutive modeling.

PubMed

Chan, Roger W; Siegmund, Thomas

2004-08-01

In human voice production (phonation), linear small-amplitude vocal fold oscillation occurs only under restricted conditions. Physiologically, phonation more often involves large-amplitude oscillation associated with tissue stresses and strains beyond their linear viscoelastic limits, particularly in the lamina propria extracellular matrix (ECM). This study reports some preliminary measurements of tissue deformation and failure response of the vocal fold ECM under large-strain shear The primary goal was to formulate and test a novel constitutive model for vocal fold tissue failure, based on a standard-linear cohesive-zone (SL-CZ) approach. Tissue specimens of the sheep vocal fold mucosa were subjected to torsional deformation in vitro, at constant strain rates corresponding to twist rates of 0.01, 0.1, and 1.0 rad/s. The vocal fold ECM demonstrated nonlinear stress-strain and rate-dependent failure response with a failure strain as low as 0.40 rad. A finite-element implementation of the SL-CZ model was capable of capturing the rate dependence in these preliminary data, demonstrating the model's potential for describing tissue failure. Further studies with additional tissue specimens and model improvements are needed to better understand vocal fold tissue failure.

Preliminary test results from a free-piston Stirling engine technology demonstration program to support advanced radioisotope space power applications

NASA Astrophysics Data System (ADS)

White, Maurice A.; Qiu, Songgang; Augenblick, Jack E.

2000-01-01

Free-piston Stirling engines offer a relatively mature, proven, long-life technology that is well-suited for advanced, high-efficiency radioisotope space power systems. Contracts from DOE and NASA are being conducted by Stirling Technology Company (STC) for the purpose of demonstrating the Stirling technology in a configuration and power level that is representative of an eventual space power system. The long-term objective is to develop a power system with an efficiency exceeding 20% that can function with a high degree of reliability for up to 15 years on deep space missions. The current technology demonstration convertors (TDC's) are completing shakedown testing and have recently demonstrated performance levels that are virtually identical to projections made during the preliminary design phase. This paper describes preliminary test results for power output, efficiency, and vibration levels. These early results demonstrate the ability of the free-piston Stirling technology to exceed objectives by approximately quadrupling the efficiency of conventional radioisotope thermoelectric generators (RTG's). .

The administration of psilocybin to healthy, hallucinogen-experienced volunteers in a mock-functional magnetic resonance imaging environment: a preliminary investigation of tolerability.

PubMed

Carhart-Harris, Robin L; Williams, Tim M; Sessa, Ben; Tyacke, Robin J; Rich, Ann S; Feilding, Amanda; Nutt, David J

2011-11-01

This study sought to assess the tolerability of intravenously administered psilocybin in healthy, hallucinogen-experienced volunteers in a mock-magnetic resonance imaging environment as a preliminary stage to a controlled investigation using functional magnetic resonance imaging to explore the effects of psilocybin on cerebral blood flow and activity. The present pilot study demonstrated that up to 2 mg of psilocybin delivered as a slow intravenous injection produces short-lived but typical drug effects that are psychologically and physiologically well tolerated. With appropriate care, this study supports the viability of functional magnetic resonance imaging work with psilocybin.

[Evaluation of preliminary grades and credits in nurse training programs].

PubMed

Darmann-Finck, Ingrid; Duveneck, Nicole

2016-01-01

In the federal state of Bremen preliminary grades were included to the extent of 25 % in written, oral and practical final grades during the time period 2009-2014. The evaluation focuses on the effects of preliminary grades on the scale of final grades and the performance of learners as well as on the assessment of the appropriateness of final grades. A mixed-methods design was employed that consisted of a quasi-experimental study comprising of surveys of students and teachers of comparative and model courses as well as a qualitative study using group discussions. The results confirm that preliminary grades lead to a minimal improvement of the final grades of some exclusively low-achieving students. The assessment of appropriateness hardly changed. From both learners' and teachers' point of view there is still great dissatisfaction concerning the practical final grades. With regard to learning habits an increased willingness to learn new skills on the one hand and a partly increased performance pressure on the other hand were demonstrated. On the basis of these research results, the authors recommend the regular introduction of preliminary marks into the nursing training. Copyright © 2016. Published by Elsevier GmbH.

The relationship between self-control, job satisfaction and life satisfaction in Chinese employees: A preliminary study.

PubMed

Dou, Kai; Nie, Yan-Gang; Wang, Yu-Jie; Liu, Yao-Zhong

2016-01-01

Previous studies have demonstrated that self-control is positively related to life satisfaction, but this association in Chinese employees and its underlying mechanism are less commonly investigated. In this preliminary study the relationships between self-control and life satisfaction and the mediating effect of job satisfaction were tested. Participants were 482 full-time employees (188 male, 294 female) from different cities in China. They answered self-report questionnaires online that assessed self-control, job satisfaction, and life satisfaction. Path analyses were conducted and bootstrap technique was used to judge the significance of the mediation. Self-control was positively related to both job and life satisfaction. More importantly, job satisfaction significantly mediated the association between self-control and life satisfaction. Furthermore, there was no significant difference in the size of the mediating effect between intrinsic and extrinsic job satisfaction. Results of this preliminary study provide further evidence of the positive association between self-control and life satisfaction. Job satisfaction is found to mediate this relationship.

Visual acuity in young elite motorsport athletes: a preliminary report.

PubMed

Schneiders, Anthony G; Sullivan, S John; Rathbone, Emma J; Louise Thayer, A; Wallis, Laura M; Wilson, Alexandra E

2010-05-01

To determine whether elite motorsport athletes demonstrate superior levels of Visual Acuity than age and sex-matched controls. A cross-sectional observational study. A University vision and balance laboratory. Young male motorsport athletes from the New Zealand Elite Motorsport Academy and healthy age and sex-matched controls. Vision performance tests comprising; Static Visual Acuity (SVA), Dynamic Visual Acuity (DVA), Gaze Stabilization Test (GST), and the Perception Time Test (PTT). Motorsport athletes demonstrated superior visual acuity compared to age and sex-matched controls for all measures, and while this was not statistically significant for SVA, GST and DVA, it reached statistical significance for the PTT (p

Defense Acquisition and the Case of the Joint Capabilities Technology Demonstration Office: Ad Hoc Problem Solving as a Mechanism for Adaptive Change

DTIC Science & Technology

2013-04-01

Capabilities Technology Demonstration Office: Ad Hoc Problem Solving as a Mechanism for Adaptive Change Kathryn Aten and John T. Dillard Naval...Defense Acquisition and the Case of the Joint Capabilities Technology Demonstration Office: Ad Hoc Problem Solving as a Mechanism for Adaptive Change...describes the preliminary analysis and findings of our study exploring what drives successful organizational adaptation in the context of technology

Children's Behavior Responses to TV Food Advertisements

ERIC Educational Resources Information Center

Clancy-Hepburn, Katherine; And Others

1974-01-01

Two preliminary studies of children's responses to TV advertisements demonstrate the complexity of responses and indicate the need for research conducted within a multidisciplinary framework. The use of the entire family as the unit of analysis is suggested. (Author/RH)

Atmospheric moisture transport and fresh water flux over oceans derived from spacebased sensors

NASA Technical Reports Server (NTRS)

Liu, W. T.; Tang, W.

2001-01-01

preliminary results will be shown to demonstrate the application of spacebased IMT and fresh water flux in ocean-atmosphere-land interaction studies, such as the hydrologica balance on Amazon rainfall and Indian monsoon.

Illustrating idiographic methods for translation research: moderation effects, natural clinical experiments, and complex treatment-by-subgroup interactions.

PubMed

Ridenour, Ty A; Wittenborn, Andrea K; Raiff, Bethany R; Benedict, Neal; Kane-Gill, Sandra

2016-03-01

A critical juncture in translation research involves the preliminary studies of intervention tools, provider training programs, policies, and other mechanisms used to leverage knowledge garnered at one translation stage into another stage. Potentially useful for such studies are rigorous techniques for conducting within-subject clinical trials, which have advanced incrementally over the last decade. However, these methods have largely not been utilized within prevention or translation contexts. The purpose of this manuscript is to demonstrate the flexibility, wide applicability, and rigor of idiographic clinical trials for preliminary testing of intervention mechanisms. Specifically demonstrated are novel uses of state-space modeling for testing intervention mechanisms of short-term outcomes, identifying heterogeneity in and moderation of within-person treatment mechanisms, a horizontal line plot to refine sampling design during the course of a clinic-based experimental study, and the need to test a treatment's efficacy as treatment is administered along with (e.g., traditional 12-month outcomes).

Preliminary analysis of cross beam data from the Gun Barrel Hill site

NASA Technical Reports Server (NTRS)

Sandborn, V. A.; Bice, A. R.; Cliff, W. C.; Hablutzel, B. C.

1974-01-01

Preliminary evaluation of cross beam data taken at the Gun Barrell Hill test site of ESSA is presented. The evaluation is made using the analog Princeton Time Correlator. A study of the frequency band width limitations of the Princeton Time Correlator is made. Based on the band width limitations, it is possible to demonstrate that nearly identical correlation is obtained for frequencies from .01 to 3.9 hertz. Difficulty is encountered in that maximums in the correlation curves do not occur at zero time lag for zero beam separations.

Stuttering on function words in bilingual children who stutter: A preliminary study.

PubMed

Gkalitsiou, Zoi; Byrd, Courtney T; Bedore, Lisa M; Taliancich-Klinger, Casey L

2017-01-01

Evidence suggests young monolingual children who stutter (CWS) are more disfluent on function than content words, particularly when produced in the initial utterance position. The purpose of the present preliminary study was to investigate whether young bilingual CWS present with this same pattern. The narrative and conversational samples of four bilingual Spanish- and English-speaking CWS were analysed. All four bilingual participants produced significantly more stuttering on function words compared to content words, irrespective of their position in the utterance, in their Spanish narrative and conversational speech samples. Three of the four participants also demonstrated more stuttering on function compared to content words in their narrative speech samples in English, but only one participant produced more stuttering on function than content words in her English conversational sample. These preliminary findings are discussed relative to linguistic planning and language proficiency and their potential contribution to stuttered speech.

Preliminary small-angle X-ray scattering and X-ray diffraction studies of the BTB domain of lola protein from Drosophila melanogaster

NASA Astrophysics Data System (ADS)

Boyko, K. M.; Nikolaeva, A. Yu.; Kachalova, G. S.; Bonchuk, A. N.; Dorovatovskii, P. V.; Popov, V. O.

2017-11-01

The Drosophila genome has several dozens of transcription factors (TTK group) containing BTB domains assembled into octamers. The LOLA protein belongs to this family. The purification, crystallization, and preliminary X-ray diffraction and small-angle X-ray scattering (SAXS) studies of the BTB domain of this protein are reported. The crystallization conditions were found by the vapor-diffusion technique. A very low diffraction resolution (8.7 Å resolution) of the crystals was insufficient for the determination of the threedimensional structure of the BTB domain. The SAXS study demonstrated that the BTB domain of the LOLA protein exists as an octamer in solution.

A preliminary study on puncture resistances of top and bottom layers of multi-layered needlepunched nonwoven geotextiles

NASA Astrophysics Data System (ADS)

Alan, G.; Tercan, M.

2017-10-01

Needlepunched nonwoven textiles are commonly used as geotextiles for various applications. Considering both environmental and economical benefits, utilization of recycled fibres in nonwoven geotextiles has become an attractive issue. Within this scope, the aim of this study is to evaluate the puncture resistance performances of top and bottom layers of multi-layered needle punched nonwovens made of recycled fibres to be used as membrane protective geotextiles by comparing them with those of made from polypropylene and polyester fibres. Puncture resistance results indicated that nonwovens made of recycled fibres demonstrated good performances at this preliminary stage.

An Analysis of Preliminary and Post-Discussion Priority Scores for Grant Applications Peer Reviewed by the Center for Scientific Review at the NIH

PubMed Central

Martin, Michael R.; Kopstein, Andrea; Janice, Joy M.

2010-01-01

There has been the impression amongst many observers that discussion of a grant application has little practical impact on the final priority scores. Rather the final score is largely dictated by the range of preliminary scores given by the assigned reviewers. The implication is that the preliminary and final scores are the same and the discussion has little impact. The purpose of this examination of the peer review process at the National Institutes of Health is to describe the relationship between preliminary priority scores of the assigned reviewers and the final priority score given by the scientific review group. This study also describes the practical importance of any differences in priority scores. Priority scores for a sample of standard (R01) research grant applications were used in this assessment. The results indicate that the preliminary meeting evaluation is positively correlated with the final meeting outcome but that they are on average significantly different. The results demonstrate that discussion at the meeting has an important practical impact on over 13% of the applications. PMID:21103331

Construction of a short form of the healthy eating behaviour inventory for the Japanese population.

PubMed

Shimazaki, Takashi; Iio, Misa; Lee, Ying-Hua; Suzuki, Akiko; Konuma, Kayo; Teshima, Yoko; Takenaka, Koji

2016-09-01

The present study constructed a short form of the Healthy Eating Behavior Inventory suitable for use in the Japanese culture (HEBI-J) and confirmed the scale's preliminary reliability and validity. In Study 1, Japanese adults (N=75) completed a free-response questionnaire about healthy eating behaviours. Thematic analysis was used to identify three factors-balance, pattern, and restriction-associated with healthy eating behaviours and 12 items related to these healthy eating behaviours. In Study 2, Japanese office workers (N=784) completed two questionnaires regarding 12 items of healthy eating behaviours and the dietary stages of change. Confirmatory factor analysis demonstrated that the three-factor model was appropriate (GFI=.94, AGFI=.90, CFI=.90, RMSEA=.08, SRMR=.53). Reliability was confirmed by alpha coefficients and the Spearman-Brown formula. Concurrent validity was confirmed by the relationship between the healthy eating stages. This study demonstrated the preliminary reliability and validity of the HEBI-J. Copyright © 2015 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

Skylab 3 and 4 science demonstrations: Preliminary report

NASA Technical Reports Server (NTRS)

Bannister, T. C.

1974-01-01

Twelve science demonstrations were accomplished on the Skylab 3 and 4 missions. These were defined in response to crew requests for time-gap fillers and were designed to be accomplished using onboard equipment. The following 12 are described and the preliminary results are given: liquid floating zone; diffusion in liquids; ice melting; immiscible liquids; liquid films; gyroscope; Rochelle salt growth; deposition of silver crystals; fluid mechanics series; neutron environment; orbital mechanics; and charged particle mobility.

Research investigations in and demonstrations of remote sensing applications to urban environmental problems

NASA Technical Reports Server (NTRS)

Hidalgo, J. U.

1975-01-01

The applicability of remote sensing to transportation and traffic analysis, urban quality, and land use problems is discussed. Other topics discussed include preliminary user analysis, potential uses, traffic study by remote sensing, and urban condition analysis using ERTS.

Weight Loss as a Primary Objective of Therapeutic Groups for Obese Women: Two Preliminary Studies

ERIC Educational Resources Information Center

Buckroyd, Julia; Rother, Sharon; Stott, David

2006-01-01

The studies reported here explored whether therapeutic groups for women who eat compulsively can demonstrate weight loss as a primary result as well as the improvements in emotional functioning reported by other investigators. In both studies questionnaire data showed little change in self-esteem or attitudes as measured by the Rosenberg…

A Preliminary Study on Building an E-Education Platform for Indian School-Level Curricula

ERIC Educational Resources Information Center

Kanth, Rajeev Kumar; Laakso, Mikko-Jussi

2016-01-01

In this study, we explore the possibilities of utilizing and implementing an e-Education platform for Indian school-level curricula. This study will demonstrate how the e-Education platform provides a positive result to the students' learning and how this tool helps in managing the overall teaching processes efficiently. Before describing the…

Data Sources for Administrators Attempting Local Reforms: A Preliminary Study of the Power Structure of a Selected Community in East Tennessee.

ERIC Educational Resources Information Center

Allen, Charlie Joe

Using techniques of the reputational method to study community power structure, this report identifies components of power structure in a Tennessee school district, demonstrates that proven methodologies can facilitate educational leaders' reform efforts, and serves as a pilot study for further investigation. Researchers investigated the district…

A Case-Based Approach Increases Student Learning Outcomes and Comprehension of Cellular Respiration Concepts

ERIC Educational Resources Information Center

Rybarczyk, Brian J.; Baines, Antonio T.; McVey, Mitch; Thompson, Joseph T.; Wilkins, Heather

2007-01-01

This study investigated student learning outcomes using a case-based approach focused on cellular respiration. Students who used the case study, relative to students who did not use the case study, exhibited a significantly greater learning gain, and demonstrated use of higher-order thinking skills. Preliminary data indicate that after engaging…

The preliminary analysis of the reliability and validity of the Chinese Edition of the CSBS DP.

PubMed

Lin, Chu-Sui; Chang, Shu-Hui; Cheng, Shu-Fen; Chao, Pen-Chiang; Chiu, Chun-Hao

2015-03-01

This study marked a preliminary attempt to standardize the Chinese Edition of the Communication and Symbolic Behavior Scales Developmental Profile (Wetherby & Prizant, 2002; CSBS DP) to assist in the early identification of young children with special needs in Taiwan. The study was conducted among 171 infants and toddlers aged 1-2. It also included a follow-up study one year after the initial test. Three domestically developed standardized child development inventories were used to measure the concurrent validity and predictive validity. The Chinese Edition of the CSBS DP demonstrated overall good test-retest and inter-rater reliability. It also showed good concurrent and predictive validity. The current study yields preliminary evidence that the Chinese Edition of the CSBS DP could be a valuable assessment tool worthy of wider distribution. Future research should employ random sampling to establish a true national norm. Additionally, the follow-up study needs to include atypical groups and to expand to children aged 6-12 months to strengthen the applicability of the instrument in Taiwan. Copyright © 2014 Elsevier Ltd. All rights reserved.

Two preliminary studies on sleep and psychotherapy.

PubMed

Karle, W; Hopper, M; Corriere, R; Hart, J; Switzer, A

1977-09-01

Two preliminary studies were conducted to assess the effects of an intensive outpatient psychotherapy, Feeling Therapy, on sleep. This therapy was chosen because of its demonstrated ability to affect its patients' dreams. In the first study a newly entering female patient was recorded across the first three weeks of intensive daily therapy. In contrast to two control subjects recorded across a similar time period, she demonstrated low REM times and short REM latencies on the average, and considerably greater variability in nearly every parameter. In the second study, two patients were recorded across three days (the middle of which was the day of a therapy session) first when new in therapy and then again after two and one-half years of therapy. It was found that when new in therapy both subjects spent nights of significantly altered sleep the day of the therapy session. One subject showed no REM sleep whatsoever while the other showed a 10 min REM latency and low REM time. The significance of these findings and the direction of future research is discussed.

Preliminary studies on readiness of biojet fuel for commercial aviation: The feasibility and potential in Malaysia

NASA Astrophysics Data System (ADS)

Noh, H. Mohd; Mahammad Taher, M. N.; Rodrigo, G. A.; Rahman, N. A. Abdul; Othman, J.; Yahaya, N. H. R.

2017-12-01

This paper demonstrates the need for a new alternative energy using biojet fuel in commercial aviation. The demand of air travels leads the authority, airlines and government in seeking for new renewable and sustainable energy for aircraft operation in the future. This study looks into the level of readiness in using biofuel. 40 personnel who are working in the aviation industries have participated and completed the survey questionnaires. The preliminary findings suggest that the impact towards this new fuel will lead to a better environment, less cost, better maintenance and energy sustainability. The usage of biojet fuel seems possible to be pursued in Malaysia.

Financial decision-making abilities and financial exploitation in older African Americans: Preliminary validity evidence for the Lichtenberg Financial Decision Rating Scale (LFDRS).

PubMed

Lichtenberg, Peter A; Ficker, Lisa J; Rahman-Filipiak, Annalise

2016-01-01

This study examines preliminary evidence for the Lichtenberg Financial Decision Rating Scale (LFDRS), a new person-centered approach to assessing capacity to make financial decisions, and its relationship to self-reported cases of financial exploitation in 69 older African Americans. More than one third of individuals reporting financial exploitation also had questionable decisional abilities. Overall, decisional ability score and current decision total were significantly associated with cognitive screening test and financial ability scores, demonstrating good criterion validity. Study findings suggest that impaired decisional abilities may render older adults more vulnerable to financial exploitation, and that the LFDRS is a valid tool.

Problem Analysis: Application in Developing Marketing Strategies for Colleges.

ERIC Educational Resources Information Center

Martin, John; Moore, Thomas

1991-01-01

The problem analysis technique can help colleges understand students' salient needs in a competitive market. A preliminary study demonstrates the usefulness of the approach for developing strategies aimed at maintaining student loyalty and improving word-of-mouth promotion to other prospective students. (Author/MSE)

PubMed Central

Serteyn, D; Pincemail, J; Mottart, E; Caudron, I; Deby, C; Deby-Dupont, G; Philippart, C; Lamy, M

1994-01-01

This preliminary study demonstrated the existence of a free radical generation during an experimental postischemic muscular reperfusion in a halothane anesthetized horse. The authors used alpha-phényl-N-tert-butylnitrone as a spin trap agent and the electronic paramagnetic resonance method to observe in vivo a free radical generation. PMID:7889465

Successful introgression of abiotic stress tolerance from wild tepary bean to common bean

USDA-ARS?s Scientific Manuscript database

Common bean (Phaseolus vulgaris L.) production is severely limited due to abiotic stresses, including drought and sub-zero temperatures. Tepary bean (Phaseolus acutifolius Gray), a relative of common bean, has demonstrated tolerance to these stresses. Preliminary studies screening tepary accessions ...

Development of polyphenylquinoxaline graphite composites

NASA Technical Reports Server (NTRS)

Hoggatt, J. T.; Hergenrother, P. M.; Shdo, J. G.

1973-01-01

The potential of polyphenylquinoxaline (PPQ)/graphite composites to serve as structural material at 316 C (600 F)has been demonstrated using a block copolymer, BlCo(13), PPQ derivative. Initially, thirteen polyphenylquinoxalines were evaluated. From this work, four candidate polymers were selected for preliminary evaluation as matrices for HMS graphite fiber reinforced composites. The preliminary composite evaluation enabled selection of one of the four polymers for advanced composite preparation and testing. Using an experimentally established cure schedule for each of the four polymers, preliminary laminates of 50% resin volume content, prepared without postcure, were tested for flexure strength and modulus, interlaminar shear strength (short beam), and tensile strength and modulus at ambient temperature. A block copolymer (Bl Co 13) derived from one mole p-bis (phenylglyoxalyl) benzene, one fourth mole 3,3'-diaminobenzidine and three-fourths mole 3,3', 4,4'-tetraminobenzophenone was selected for extensive study. Tensile, flexural, and interlaminar shear values were obtained after aging and testing postcured BlCo(13) laminates at 316 C (600 F). The potential of PPQ/graphite laminates to serve as short term structural materials at temperatures up to 371 C (700 F) was demonstrated through weight loss experiments.

Preliminary concepts for a solar electric orbit raising experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cohen, R.B.; Penn, J.P.; Janson, S.W.

1989-01-01

Some preliminary concepts for a solar electric orbit raising demonstration that will show technological readiness for the development of operational Electric Orbital Transfer Vehicles (EOTVs) are outlined. These ideas could serve as a template for the proposed Electric Insertion Transfer Experiment (ELITE). At this moment, ELITE is not a funded program. Concepts are presented for a solar electric orbit raising demonstration, for ELITE, and for the path from the proposed ELITE to a future operational EOTV. A brief discussion of the benefits to be derived from the use of EOTVs, the conceptual organization of the ELITE team, the key technologiesmore » for EOTV and ELITE, and some preliminary options for the orbit raising vehicle and representative missions are provided.« less

Results of the 1998 Field Demonstration and Preliminary Implementation Guidance for Phytoremediation of Lead-Contaminated Soil at the Twin Cities Army Ammunition Plant, Arden Hills, Minnesota

DTIC Science & Technology

1999-03-01

Results of the 1998 Field Demonstration and Preliminary Implementation Guidance for Phytoremediation of Lead-Contaminated Soil at the Twin... Phytoremediation of Lead-Contaminated Soil at the Twin Cities Army Ammunition Plant, Arden Hills, Minnesota. 12. PERSONAL AUTHOR(S) A. P. Behel, Jr...CODES FIELD GROUP SUB-GROUP 18. SUBJECT TERMS (Continue on reverse if necessary and identify by block number) Phytoremediation of Lead-Contaminated

A Comparative Study of Competency-Based Courses Demonstrating a Potential Measure of Course Quality and Student Success

ERIC Educational Resources Information Center

Krause, Jackie; Dias, Laura Portolese; Schedler, Chris

2015-01-01

While competency-based education is growing, standardized tools for evaluating the unique characteristics of course design in this domain are still under development. This preliminary research study evaluated the effectiveness of a rubric developed for assessing course design of competency-based courses in an undergraduate Information Technology…

A Process Evaluation of Project Developmental Continuity, Interim Report VI: Recommendations for Continuing the Impact Study.

ERIC Educational Resources Information Center

Granville, Arthur; And Others

This interim report re-examines data on instrument suitability, comparability of groups, and adequacy of sample size in Year III of the process evaluation of Project Developmental Continuity (PDC) and offers preliminary recommendations concerning the feasibility of continuing the impact study. PDC is a Head Start demonstration program aimed at…

Preliminary findings on the Cross Cultural Test Of Face Recognition.

PubMed

O'Bryant, Sid E; McCaffrey, Robert J

2006-01-01

The utility of psychological tests cross-culturally has received a great deal of attention in psychology. However, this same level of attentiveness has yet to be realized in the field of neuropsychology. One such area of neuropsychological assessment that may be negatively impacted by racial and ethnic variables is the assessment of facial memory. There is a plethora of literature in cognitive psychology demonstrating an own-race recognition bias in human face memory. Simply stated, individuals are more apt to accurately remember faces of individuals who are of their own race rather than those of other races. Study 1 was conducted to evaluate the performance of the Cross Cultural Test of Face Recognition (CCTFR) in a diverse sample of non impaired individuals. Results suggested the presence of an own-race recognition bias present, but this had no impact on overall CCTFR performance. Study 2 was conducted to determine if CVA patients would perform more poorly than community controls on the CCTFR. As predicted, community controls significantly outperformed CVA patients, and the CCTFR demonstrated a moderate level of sensitivity and specificity. Combined, the results of these studies provide preliminary support for the utility of the CCTFR in the neuropsychological assessment of diverse patient populations. Clearly more research is needed to support the utility of this new test of face recognition, but preliminary results suggest that it may be a viable option for the assessment of visual memory across a spectrum of ethnic groups.

Will environmental interventions affect the level of mastery motivation among children with disabilities? A preliminary study.

PubMed

Waldman-Levi, Amiya; Erez, Asnat Bar-Haim

2015-03-01

Children with developmental disabilities tend to demonstrate lower levels of mastery motivation in comparison with typically developing children. The goal of this study was to investigate the effect of physical and social environmental interventions on the mastery motivation of children with disabilities. Participants included 19 children (from two classes) with disabilities between the ages of 2-4 years from an educational rehabilitation centre. The Individualized Assessment of Mastery Motivation was used to assess the level of mastery motivation; the Early Childhood Environment Rating Scale - Revised and the Teacher-Child Interaction Observation were used to assess the physical and social environments. A counterbalance study design was used such that the children from the two classes received two phases of intervention, social and physical environmental interventions. The study's results point to the advantage of the social intervention, over the physical one, in improving the child's mastery motivation. However, the results lend support for the efficacy of using both aspects of environmental changes to the overall persistent score. The study findings, although preliminary, demonstrate the efficacy of providing both social and physical environmental interventions to improve mastery motivation. Copyright © 2014 John Wiley & Sons, Ltd.

Health, Quality of Life and Population Density: A Preliminary Study on "Contextualized" Quality of Life

ERIC Educational Resources Information Center

Fassio, Omar; Rollero, Chiara; De Piccoli, Norma

2013-01-01

Quality of life concerns individual (physical and psychological health), interpersonal (social relationships) and contextual (environment) aspects, which are both subjective and objective. In considering contextual characteristics, empirical findings have demonstrated that people's relation to their living environment is a key issue for their…

Confocal microscopy to guide laser ablation of basal cell carinoma: a preliminary feasibility study

NASA Astrophysics Data System (ADS)

Larson, Bjorg A.; Sierra, Heidy; Chen, Jason; Rajadhyaksha, Milind

2013-03-01

Laser ablation may be a promising method for removal of skin lesions, with the potential for better cosmetic outcomes and reduced scarring and infection. An obstacle to implementing laser ablation is that the treatment leaves no tissue for histopathological analysis. Pre-operative and intra-operative mapping of BCCs using confocal microscopy may guide the ablation of the tumor until all tumor is removed. We demonstrate preliminary feasibility of confocal microscopy to guide laser ablation of BCCs in freshly excised tissue from Mohs surgery. A 2940 nm Er:YAG laser provides efficient ablation of tumor with reduced thermal damage to the surrounding tissue.

Sound-Field Amplification: Preliminary Information Regarding Special Education Referrals

ERIC Educational Resources Information Center

Flexer, C.; Long, S.

2004-01-01

In this clinical exchange, the authors discuss acoustic accessibility and sound-field amplification in general education classrooms. They bridge theory to practice by presenting preliminary information from two different school systems demonstrating how an improved signal-to-noise ratio can have a positive impact on special education referrals.

The Role of Empowerment in a School-Based Community Service Program with Inner-City, Minority Youth

PubMed Central

Gullan, Rebecca L.; Power, Thomas J.; Leff, Stephen S.

2014-01-01

Despite considerable fiscal and structural support for youth service programs, research has not demonstrated consistent outcomes across participants or programs, suggesting the need to identify critical program processes. The present study addresses this need through preliminary examination of the role of program empowerment in promoting positive identity development in inner-city, African American youth participating in a pilot school-based service program. Results suggest that participants who experienced the program as empowering experienced increases in self-efficacy, sense of civic responsibility, and ethnic identity, over and above general engagement and enjoyment of the program. Preliminary exploration of differences based on participant gender suggests that some results may be stronger and more consistent for males than females. These findings provide preliminary support for the importance of theoretically grounded program processes in producing positive outcomes for youth service participants. PMID:25104875

System description and analysis. Part 1: Feasibility study for helicopter/VTOL wide-angle simulation image generation display system

NASA Technical Reports Server (NTRS)

1977-01-01

A preliminary design for a helicopter/VSTOL wide angle simulator image generation display system is studied. The visual system is to become part of a simulator capability to support Army aviation systems research and development within the near term. As required for the Army to simulate a wide range of aircraft characteristics, versatility and ease of changing cockpit configurations were primary considerations of the study. Due to the Army's interest in low altitude flight and descents into and landing in constrained areas, particular emphasis is given to wide field of view, resolution, brightness, contrast, and color. The visual display study includes a preliminary design, demonstrated feasibility of advanced concepts, and a plan for subsequent detail design and development. Analysis and tradeoff considerations for various visual system elements are outlined and discussed.

Reference method for total water in lint cotton by automated oven drying combined with volumetric Karl Fischer titration

USDA-ARS?s Scientific Manuscript database

In a preliminary study to measure total water in lint cotton we demonstrated that volumetric Karl Fischer Titration of moisture transported by a carrier gas from an attached small oven is more accurate than standard oven drying in air. The objective of the present study was to assess the measuremen...

SERT C project study

NASA Technical Reports Server (NTRS)

1974-01-01

The SERT C (Space Electric Rocket Test - C) project study defines a spacecraft mission that would demonstrate the technology readiness of ion thruster systems for primary propulsion and station keeping applications. As a low cost precursor, SERT C develops the components and systems required for subsequent Solar Electric Propulsion (SEP) applications. The SERT C mission requirements and preliminary spacecraft and subsystem design are described.

Effects of Trichothecenes on Cardiac Cell Electrical Function

DTIC Science & Technology

1985-12-16

toxic effects . These studies demonstrated unequivocal reversible effects of certain mycotoxins on heart cell electrical activity. Preliminary studies...muscle cells shown in Figure 8 illustrate the typical effects of trichothecene mycotoxins in canine ventricular cells. T-2 tetraol, for 3xample...false tendon cells and V ventricular muscle cells (shown in Figure 8) illustrate the typical effects of trichothecene mycotoxins in canine cardiac

Validating a Culturally-Sensitive Social Competence Training Programme for Adolescents with ASD in a Chinese Context: An Initial Investigation

ERIC Educational Resources Information Center

Chan, Raymond Won Shing; Leung, Cecilia Nga Wing; Ng, Denise Ching Yiu; Yau, Sania Sau Wai

2018-01-01

Previous studies on social skills training on ASD were done almost exclusively in the West with children as the main subjects. Demonstrations of the applicability of social interventions in different cultures and age groups are warranted. The current study outlined the development and preliminary evaluation of a CBT-context-based social competence…

Preliminary experiments on active control of fan noise from a turbofan engine

NASA Technical Reports Server (NTRS)

Thomas, R. H.; Burdisso, R. A.; Fuller, C. R.; O'Brien, W. F.

1993-01-01

In the preliminary experiments reported here, active acoustic sources positioned around the circumference of a turbofan engine were used to control the fan noise radiated forward through the inlet. The main objective was to demonstrate the potential of active techniques to alleviate the noise pollution that will be produced by the next generation of larger engines. A reduction of up to 19 dB in the radiation directivity was demonstrated in a zone that encompasses a 30-deg angle, near the error sensor, while spillover effects were observed toward the lateral direction. The simultaneous control of two tones was also demonstrated using two identical controllers in a parallel control configuration.

Aberrant expression of interleukin-22 and its targeting microRNAs in oral lichen planus: a preliminary study.

PubMed

Shen, Zhengyu; Du, Guanhuan; Zhou, Zengtong; Liu, Wei; Shi, Linjun; Xu, Hui

2016-08-01

Oral lichen planus (OLP) is a T cell-mediated autoimmune disease involving oral mucosa. Interleukin-22 (IL-22) as the signature cytokine of T helper 22 cells is increasingly recognized as a key regulator in various autoimmune diseases. Our previous study reported that IL-22 immunoexpression in OLP was significantly increased compared with the normal controls. The objective of this preliminary study was to compare the IL-22 expression levels in oral biopsies from patients with OLP (n = 50) against normal oral mucosa (n = 19) using RT-qPCR and Western blot, identify the potential targeting miRNAs of IL-22, and examine the miRNA expression levels in OLP. Interleukin-22 expression level in OLP was significantly increased compared with the normal controls. The Dual-Luciferase reporter assay system in human embryonic kidney 293 (HEK293) cells demonstrated that miR-562 and miR-203 were the target miRNAs of IL-22, which was consistent with predictions from bioinformatics software analyses. Interestingly, miR-562 expression in OLP was significantly decreased, but miR-203 expression in OLP was significantly increased compared with the normal controls. This preliminary study for the first time reported that aberrant expression levels of miR-562 and miR-203 were associated with high expression of IL-22 and demonstrated the target relationship between miRNAs and IL-22 in HEK293 cells. Our data indicated that IL-22 and its targeting miRNAs contribute to the pathogenesis of OLP. Further studies are required to investigate the regulatory pathways of IL-22 and miR-562 and miR-203 in OLP. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

The development and preliminary testing of a multimedia patient-provider survivorship communication module for breast cancer survivors.

PubMed

Wen, Kuang-Yi; Miller, Suzanne M; Stanton, Annette L; Fleisher, Linda; Morra, Marion E; Jorge, Alexandra; Diefenbach, Michael A; Ropka, Mary E; Marcus, Alfred C

2012-08-01

This paper describes the development of a theory-guided and evidence-based multimedia training module to facilitate breast cancer survivors' preparedness for effective communication with their health care providers after active treatment. The iterative developmental process used included: (1) theory and evidence-based content development and vetting; (2) user testing; (3) usability testing; and (4) participant module utilization. Formative evaluation of the training module prototype occurred through user testing (n = 12), resulting in modification of the content and layout. Usability testing (n = 10) was employed to improve module functionality. Preliminary web usage data (n = 256, mean age = 53, 94.5% White, 75% college graduate and above) showed that 59% of the participants accessed the communication module, for an average of 7 min per login. The iterative developmental process was informative in enhancing the relevance of the communication module. Preliminary web usage results demonstrate the potential feasibility of such a program. Our study demonstrates survivors' openness to the use of a web-based communication skills training module and outlines a systematic iterative user and interface program development and testing process, which can serve as a prototype for others considering such an approach. Copyright © 2012. Published by Elsevier Ireland Ltd.

The development and preliminary testing of a multimedia patient–provider survivorship communication module for breast cancer survivors

PubMed Central

Wen, Kuang-Yi; Miller, Suzanne M.; Stanton, Annette L.; Fleisher, Linda; Morra, Marion E.; Jorge, Alexandra; Diefenbach, Michael A.; Ropka, Mary E.; Marcus, Alfred C.

2012-01-01

Objective This paper describes the development of a theory-guided and evidence-based multimedia training module to facilitate breast cancer survivors’ preparedness for effective communication with their health care providers after active treatment. Methods The iterative developmental process used included: (1) theory and evidence-based content development and vetting; (2) user testing; (3) usability testing; and (4) participant module utilization. Results Formative evaluation of the training module prototype occurred through user testing (n = 12), resulting in modification of the content and layout. Usability testing (n = 10) was employed to improve module functionality. Preliminary web usage data (n = 256, mean age = 53, 94.5% White, 75% college graduate and above) showed that 59% of the participants accessed the communication module, for an average of 7 min per login. Conclusion The iterative developmental process was informative in enhancing the relevance of the communication module. Preliminary web usage results demonstrate the potential feasibility of such a program. Practice implications Our study demonstrates survivors’ openness to the use of a web-based communication skills training module and outlines a systematic iterative user and interface program development and testing process, which can serve as a prototype for others considering such an approach. PMID:22770812

Preliminary Design and Analysis of an In-plane PRSEUS Joint

NASA Technical Reports Server (NTRS)

Lovejoy, Andrew E.; Poplawski, Steven

2013-01-01

As part of the National Aeronautics and Space Administration's (NASA's) Environmentally Responsible Aviation (ERA) program, the Pultruded Rod Stitched Efficient Unitized Structure (PRSEUS) has been designed, developed and tested. However, PRSEUS development efforts to date have only addressed joints required to transfer bending moments between PRSEUS panels. Development of in-plane joints for the PRSEUS concept is necessary to facilitate in-plane transfer of load from PRSEUS panels to an adjacent structure, such as from a wing panel into a fuselage. This paper presents preliminary design and analysis of an in-plane PRSEUS joint for connecting PRSEUS panels at the termination of the rod-stiffened stringers. Design requirements are provided, the PRSEUS blade joint concept is presented, and preliminary design changes and analyses are carried out to examine the feasibility of the proposed in-plane PRSEUS blade joint. The study conducted herein focuses mainly on the PRSEUS structure on one side of the joint. In particular, the design requirements for the rod shear stress and bolt bearing stress are examined. A PRSEUS blade joint design was developed that demonstrates the feasibility of this in-plane PRSEUS joint concept to terminate the rod-stiffened stringers. The presented design only demonstrates feasibility, therefore, some areas of refinement are presented that would lead to a more optimum and realistic design.

On board processor development for NASA's spaceborne imaging radar with system-on-chip technology

NASA Technical Reports Server (NTRS)

Fang, Wai-Chi

2004-01-01

This paper reports a preliminary study result of an on-board spaceborne SAR processor. It consists of a processing requirement analysis, functional specifications, and implementation with system-on-chip technology. Finally, a minimum version of this on-board processor designed for performance evaluation and for partial demonstration is illustrated.

Creating Micro-Videos to Demonstrate Technology Learning

ERIC Educational Resources Information Center

Frydenberg, Mark; Andone, Diana

2016-01-01

Short videos, also known as micro-videos, have emerged as a platform for sharing ideas, experiences, and life events on online social networks. This paper shares preliminary results of a study involving students from two universities who created six-second videos using the Vine mobile app to explain or illustrate technology concepts. An analysis…

Dientamoeba fragilis in swine population: a preliminary investigation.

PubMed

Crotti, D; Sensi, M; Crotti, S; Grelloni, V; Manuali, E

2007-04-30

Dientamoeba fragilis, a protozoan with worldwide distribution is considered to be responsible for enteric disease in humans. A wide spectrum of clinical symptoms including; diarrhoea (acute or prolonged), flatulence, abdominal pains and other unspecific bowel symptoms have been ascribed to this parasite. Asymptomatic infection has also been reported. Dientamoeba fragilis is as its name indicates an extremely delicate protozoon and only the trophozoite has ever been demonstrated in stool samples. The definitive diagnosis of this infection is based on demonstration in permanently stained stool samples. In Italy examination of ova and parasite (O&P) samples are not currently performed. This protozoan is extremely difficult to cultivate but molecular techniques such as the Polymerase Chain Reaction offer promise as a means of diagnosing infection. The epidemiology of Dientamoebiasis is not clear. This paper will present preliminary results from a study looking for the parasite's presence in swine faeces. The possible role of pigs as a reservoir of infection was studied; 121 faecal samples from breeding and fattening pigs were examined using a Giemsa permanent stain. Dientamoeba fragilis was found in 53 (43.8%) of the stool samples examined.

Variable Cycle Engine Technology Program Planning and Definition Study

NASA Technical Reports Server (NTRS)

Westmoreland, J. S.; Stern, A. M.

1978-01-01

The variable stream control engine, VSCE-502B, was selected as the base engine, with the inverted flow engine concept selected as a backup. Critical component technologies were identified, and technology programs were formulated. Several engine configurations were defined on a preliminary basis to serve as demonstration vehicles for the various technologies. The different configurations present compromises in cost, technical risk, and technology return. Plans for possible variably cycle engine technology programs were formulated by synthesizing the technology requirements with the different demonstrator configurations.

Preliminary neutronics design of china lead-alloy cooled demonstration reactor (CLEAR-III) for nuclear waste transmutation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Z.; Southwest Science and Technology Univ., No.350 Shushanhu Road, Shushan District, Hefei, Anhui, 230031; Chen, Y.

2012-07-01

China Lead-Alloy cooled Demonstration Reactor (CLEAR-III), which is the concept of lead-bismuth cooled accelerator driven sub-critical reactor for nuclear waste transmutation, was proposed and designed by FDS team in China. In this study, preliminary neutronics design studies have primarily focused on three important performance parameters including Transmutation Support Ratio (TSR), effective multiplication factor and blanket thermal power. The constraint parameters, such as power peaking factor and initial TRU loading, were also considered. In the specific design, uranium-free metallic dispersion fuel of (TRU-Zr)-Zr was used as one of the CLEAR-III fuel types and the ratio between MA and Pu was adjustedmore » to maximize transmutation ratio. In addition, three different fuel zones differing in the TRU fraction of the fuel were respectively employed for this subcritical reactor, and the zone sizes and TRU fractions were determined such that the linear powers of these zones were close to each other. The neutronics calculations and analyses were performed by using Multi-Functional 4D Neutronics Simulation System named VisualBUS and nuclear data library HENDL (Hybrid Evaluated Nuclear Data Library). In the preliminary design, the maximum TSRLLMA was {approx}11 and the blanket thermal power was {approx}1000 MW when the effective multiplication factor was 0.98. The results showed that good performance of transmutation could be achieved based on the subcritical reactor loaded with uranium-free fuel. (authors)« less

Evaluation of a Short-Term Computer-Assisted Training Programme for the Remediation of Attentional Deficits after Brain Injury: A Preliminary Study.

ERIC Educational Resources Information Center

Gauggel, S.; Niemann, T.

1996-01-01

This study evaluated a computer-assisted training program used by four patients (ages 40 to 53) who had attentional deficits caused by cerebrovascular accident and closed head injury. Patients demonstrated improvements in training tasks, attention, and visual memory, but no improvements in two verbal memory tests and a general intelligence test.…

Cohesion to the Group and Its Association with Attendance and Early Treatment Response in an Adult Day-Hospital Program for Eating Disorders: A Preliminary Clinical Investigation

ERIC Educational Resources Information Center

Crino, Natalie; Djokvucic, Ivana

2010-01-01

Treatment outcome studies demonstrate that day-hospital programs are effective in the treatment of eating disorders. Few descriptions are available on the specifics of treatment, particularly the process of therapy. The group therapy modality is thought to provide important therapeutic benefits. The present study aimed to examine the association…

Effects of space environment on structural materials - A preliminary study and development of materials characterization protocols

NASA Technical Reports Server (NTRS)

Miglionico, C.; Stein, C.; Murr, L. E.

1991-01-01

A preliminary study of materials exposed in space in LEO for nearly six years in the NASA Long-Duration Exposure Facility is presented. It is demonstrated that it will be necessary to isolate surface debris and reaction products from materials exposed in space. Replication techniques originally designed for electron microscopy examination of surfaces can be applied to lift off and isolate such surface features. Debris and reaction products were examined through a variety of analytical techniques, including the surface morphology by SEM, and internal microstructures by STEM and TEM, EDS, and SAD. The results illustrate the role that atomic oxygen and micrometeorites play in surface alteration and reaction in LEO space environments, as well as the role of debris created from other proximate materials.

Respirator fit of a medium mask on a group of South Africans: a cross-sectional study

PubMed Central

2011-01-01

Background In South Africa, respiratory protective equipment is often the primary control method used to protect workers. This preliminary study investigated how well a common disposable P2 respirator fitted persons with a range of facial dimensions. Methods Quantitative respirator fit tests were performed on 29 volunteers from different racial, gender and face size groups. Two facial dimensions width (bizygomatic) and length (menton-sellion) were measured for all participants. Results In this study 13.8% of the participants demonstrated a successful fit with the medium sized mask. These included participants from three different racial and both gender groups. The large percentage of failed fit tests (86%) indicates that reliance on off-the-shelf respirators could be problematic in South Africa. Conclusions The limitations of this preliminary study notwithstanding, respirator fit appear to be associated with individual facial characteristics and are not specific to racial/ethnic or gender characteristics. PMID:21406106

Development and initial validation of an instrument to assess stressors among South African sports coaches.

PubMed

Kubayi, Alliance; Toriola, Abel; Didymus, Faye

2018-06-01

The aim of this series of studies was to develop and initially validate an instrument to assess stressors among South African sports coaches. In study one, a preliminary pool of 45 items was developed based on existing literature and an expert panel was employed to assess the content validity and applicability of these items. In study two, the 32 items that were retained after study one were analysed using principal component analysis (PCA). The resultant factorial structure comprised four components: environmental stressors, performance stressors, task-related stressors, and athlete stressors. These four components were made up of 26 items and, together, the components and items comprised the provisional Stressors in Sports Coaching Questionnaire (SSCQ). The results show that the SSCQ demonstrates acceptable internal consistency (.73-.89). The findings provide preliminary evidence that SSCQ is a valid tool to assess stressors among South African sports coaches.

The design, analysis, and testing of a low-budget wind-tunnel flutter model with active aerodynamic controls

NASA Technical Reports Server (NTRS)

Bolding, R. M.; Stearman, R. O.

1976-01-01

A low budget flutter model incorporating active aerodynamic controls for flutter suppression studies was designed as both an educational and research tool to study the interfering lifting surface flutter phenomenon in the form of a swept wing-tail configuration. A flutter suppression mechanism was demonstrated on a simple semirigid three-degree-of-freedom flutter model of this configuration employing an active stabilator control, and was then verified analytically using a doublet lattice lifting surface code and the model's measured mass, mode shapes, and frequencies in a flutter analysis. Preliminary studies were significantly encouraging to extend the analysis to the larger degree of freedom AFFDL wing-tail flutter model where additional analytical flutter suppression studies indicated significant gains in flutter margins could be achieved. The analytical and experimental design of a flutter suppression system for the AFFDL model is presented along with the results of a preliminary passive flutter test.

A preliminary neutron crystallographic study of thaumatin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Teixeira, Susana C. M.; Institut Laue Langevin, 6 Rue Jules Horowitz, 38042 Grenoble; EPSAM and ISTM, Keele University, Staffordshire ST5 5BG

2008-05-01

Preliminary neutron crystallographic data from the sweet protein thaumatin have been recorded using the LADI-III diffractometer at the Institut Laue Langevin (ILL). The results illustrate the feasibility of a full neutron structural analysis aimed at further understanding the molecular basis of the perception of sweet taste. Such an analysis will exploit the use of perdeuterated thaumatin. A preliminary neutron crystallographic study of the sweet protein thaumatin is presented. Large hydrogenated crystals were prepared in deuterated crystallization buffer using the gel-acupuncture method. Data were collected to a resolution of 2 Å on the LADI-III diffractometer at the Institut Laue Langevin (ILL).more » The results demonstrate the feasibility of a full neutron crystallographic analysis of this structure aimed at providing relevant information on the location of H atoms, the distribution of charge on the protein surface and localized water in the structure. This information will be of interest for understanding the specificity of thaumatin–receptor interactions and will contribute to further understanding of the molecular mechanisms underlying the perception of taste.« less

A preliminary investigation into theory of mind and attributional style in adults with grandiose delusions.

PubMed

Boyden, Paul; Knowles, Rebecca; Corcoran, Rhiannon; Hamilton, Simon; Rowse, Georgina

2015-01-01

A preliminary cognitive model of grandiose delusions has been put forward suggesting that persecutory and grandiose delusions shared distinct, yet overlapping psychological processes. This study aims to test this model and hypothesises that participants experiencing grandiose delusions may demonstrate a theory of mind (ToM) impairment and differences in attributional style compared to a control group. A cross-sectional design compared the performance of 18 individuals with grandiose delusions to a control group of 14 participants with depression. ToM was measured using a non-verbal joke appreciation task and a verbal stories task. Attributional style was measured using the internal, personal and situational attributions questionnaire. Participants experiencing grandiose delusions performed significantly worse on both ToM tasks compared to controls. Furthermore, these participants provided significantly more atypical answers when explaining the joke behind the ToM cartoons. No differences for subjective funniness ratings or attributional style were found. This preliminary study indicated participants experiencing grandiose delusions have ToM impairments which may contribute to the maintenance of this symptom.

Human factors engineering and design validation for the redesigned follitropin alfa pen injection device.

PubMed

Mahony, Mary C; Patterson, Patricia; Hayward, Brooke; North, Robert; Green, Dawne

2015-05-01

To demonstrate, using human factors engineering (HFE), that a redesigned, pre-filled, ready-to-use, pre-asembled follitropin alfa pen can be used to administer prescribed follitropin alfa doses safely and accurately. A failure modes and effects analysis identified hazards and harms potentially caused by use errors; risk-control measures were implemented to ensure acceptable device use risk management. Participants were women with infertility, their significant others, and fertility nurse (FN) professionals. Preliminary testing included 'Instructions for Use' (IFU) and pre-validation studies. Validation studies used simulated injections in a representative use environment; participants received prior training on pen use. User performance in preliminary testing led to IFU revisions and a change to outer needle cap design to mitigate needle stick potential. In the first validation study (49 users, 343 simulated injections), in the FN group, one observed critical use error resulted in a device design modification and another in an IFU change. A second validation study tested the mitigation strategies; previously reported use errors were not repeated. Through an iterative process involving a series of studies, modifications were made to the pen design and IFU. Simulated-use testing demonstrated that the redesigned pen can be used to administer follitropin alfa effectively and safely.

Preliminary findings of altered functional connectivity of the default mode network linked to functional outcomes one year after pediatric traumatic brain injury.

PubMed

Stephens, Jaclyn A; Salorio, Cynthia F; Barber, Anita D; Risen, Sarah R; Mostofsky, Stewart H; Suskauer, Stacy J

2017-07-10

This study examined functional connectivity of the default mode network (DMN) and examined brain-behavior relationships in a pilot cohort of children with chronic mild to moderate traumatic brain injury (TBI). Compared to uninjured peers, children with TBI demonstrated less anti-correlated functional connectivity between DMN and right Brodmann Area 40 (BA 40). In children with TBI, more anomalous less anti-correlated) connectivity between DMN and right BA 40 was linked to poorer performance on response inhibition tasks. Collectively, these preliminary findings suggest that functional connectivity between DMN and BA 40 may relate to longterm functional outcomes in chronic pediatric TBI.

Mycological studies housed in the Apollo 16 microbial ecology evaluation device

NASA Technical Reports Server (NTRS)

Volz, P. A.

1973-01-01

Survival, death, and phenotype count have yielded variation in the number of fungi recovered from the controls and the flight exposed cuvettes during preliminary analysis of postflight first phase data. Also the preliminary analysis was indicative that fungi exposed to specific space flight conditions demonstrated variable survival rates and phenotype counts. Specific space flight conditions included full light space exposure for Chaetomium globosum, exposure at 300- and 254-nanometer wavelengths for Rhodotorula rubra, full light and 280-nanometer wavelength exposure for Trichophyton terrestre, and 254-nanometer wavelength exposure for Saccharomyces cerevisiae. In general, phenotype counts for flight cuvettes and survival rates for control cuvettes were higher compared with the remaining cuvettes.

Preliminary analytical results for ash and burned soils from the October 2007 southern California wildfires

USGS Publications Warehouse

Plumlee, Geoffrey S.; Martin, Deborah A.; Hoefen, Todd; Kokaly, Raymond F.; Hageman, Philip; Eckberg, Alison; Meeker, Gregory P.; Adams, Monique; Anthony, Michael; Lamothe, Paul J.

2007-01-01

The U.S. Geological Survey (USGS) collected ash and burned soils from about 28 sites in southern California wildfire areas (Harris, Witch, Ammo, Santiago, Canyon and Grass Valley) from Nov. 2 through 9, 2007 (table 1). USGS researchers are applying a wide variety of analytical methods to these samples, with the goal of helping identify characteristics of the ash and soils from wildland and suburban burned areas that may be of concern for their potential to adversely affect water quality, human health, endangered species, and debris-flow or flooding hazards. These studies are part of the Southern California Multi-Hazards Demonstration Project, and preliminary findings are presented here.

The NN-explore Exoplanet Stellar Speckle Imager: Instrument Description and Preliminary Results

NASA Astrophysics Data System (ADS)

Scott, Nicholas J.; Howell, Steve B.; Horch, Elliott P.; Everett, Mark E.

2018-05-01

A new speckle and wide-field imaging instrument for the WIYN telescope called NN-EXPLORE Exoplanet Stellar Speckle Imager (NESSI) is described. NESSI offers simultaneous two-color diffraction-limited imaging and wide-field traditional imaging for validation and characterization of transit and precision RV exoplanet studies. Many exoplanet targets will come from the NASA K2 and Transiting Exoplanet Survey Satellite (TESS) missions. NESSI is capable of resolving close binaries at sub-arcsecond separations down to the diffraction limit and >6 mag contrast difference in the visible band on targets as faint as 14th mag. Preliminary results from the instrument commissioning at WIYN and demonstrations of the instrument’s capabilities are presented.

Preliminary demonstration using localized skin temperature elevation as observed with thermal imaging as an indicator of fat-specific absorption during focused-field radiofrequency therapy.

PubMed

Key, Douglas J

2014-07-01

This study incorporates concurrent thermal camera imaging as a means of both safely extending the length of each treatment session within skin surface temperature tolerances and to demonstrate not only the homogeneous nature of skin surface temperature heating but the distribution of that heating pattern as a reflection of localization of subcutaneous fat distribution. Five subjects were selected because of a desire to reduce abdomen and flank fullness. Full treatment field thermal camera imaging was captured at 15 minute intervals, specifically at 15, 30, and 45 minutes into active treatment with the purpose of monitoring skin temperature and avoiding any patterns of skin temperature excess. Peak areas of heating corresponded anatomically to the patients' areas of greatest fat excess ie, visible "pinchable" fat. Preliminary observation of high-resolution thermal camera imaging used concurrently with focused field RF therapy show peak skin heating patterns overlying the areas of greatest fat excess.

EXECUTIVE SUMMARY FOR FULL-SCALE DUAL-ALKALI DEMONSTRATION AT LOUISVILLE GAS AND ELECTRIC CO. - PRELIMINARY DESIGN AND COST ESTIMATE

EPA Science Inventory

The report is the executive summary for the preliminary design of the dual-alkali system, designed by Combustion Equipment Associates, Inc./Arthur D. Little, Inc. and being installed to control SO2 emissions from Louisville Gas and Electric Company's Cane Run Unit No. 6 boiler. T...

Preliminary Evaluation Report on the Los Angeles City Schools, SB 28 Demonstration Program in Mathematics.

ERIC Educational Resources Information Center

Gordon, C. Wayne

The purpose of this preliminary report is to describe and evaluate the Los Angeles Model Mathematics Project (LAMMP). The objectives of this project include the improvement of mathematical skills and understanding of mathematical concepts, the improvement of students' self-image, the development of instructional materials and the assessment of…

76 FR 56147 - Certain Steel Nails From the People's Republic of China: Preliminary Results and Preliminary...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-12

... electroplating or hot dipping one or more times), phosphate cement, and paint. Head styles include, but are not... control and thus should be assessed a single antidumping duty rate.\\28\\ Exporters can demonstrate this independence through the absence of both de jure and de facto government control over export activities. Id...

Bully Prevention in Positive Behavior Support: Preliminary Evaluation of Third-, Fourth-, and Fifth-Grade Attitudes toward Bullying

ERIC Educational Resources Information Center

Ross, Scott W.; Horner, Robert H.

2014-01-01

The current pilot study demonstrates the potential of adding simple and efficient bully prevention strategies to already established School-Wide Positive Behavior Interventions and Supports. The self-report surveys of third-, fourth-, and fifth-grade students from three elementary schools evaluated the relationship between the implementation of…

Assessing Self-Efficacy Beliefs and Academic Outcomes: The Case for Specificity and Correspondence.

ERIC Educational Resources Information Center

Pajares, Frank

Guidelines regarding self-efficacy assessment are highlighted in the first section of this paper. In the second section, the issue of specificity versus generality of measurement is clarified. And last, preliminary results of a study of eighth graders (n=172) are presented which demonstrate that: (1) the optimal level of specificity of any…

A Preliminary Outcome Study of an Outpatient Treatment Program for Gamblers.

ERIC Educational Resources Information Center

Blackman, Sheldon; And Others

The Gamblers Treatment Clinic (GTC) opened in 1982 as a New York State Office of Mental Health Demonstration Program. The basic premise of the GTC is that excessive gambling is a disorder of impulse control. Treatment, conducted in the community in a time-limited fashion, attempts to uncover the underlying dynamics that precipitate disorders of…

Using PANDA (Preventing the Abuse of Tobacco, Narcotics, Drugs, and Alcohol) in a Baltimore City Head Start Setting: A Preliminary Study.

ERIC Educational Resources Information Center

Belcher, Harolyn M. E.; Lockhart, Paula J.; Perkins-Parks, Susan; McNally, Margaret

2000-01-01

Describes an evaluation of a substance abuse prevention curriculum, Preventing the Abuse of Tobacco, Narcotics, Drugs, and Alcohol (PANDA), taught to African American Head Start preschool students, examining changes in children's self-concept following participation. Overall, students demonstrated significantly improved self-concept, and PANDA…

Creating Micro-Videos to Demonstrate Technology Learning and Digital Literacy

ERIC Educational Resources Information Center

Frydenberg, Mark; Andone, Diana

2016-01-01

Purpose: Short videos, also known as micro-videos, have emerged as a platform for sharing ideas, experiences and life events via online social networks. This paper aims to share preliminary results of a study, involving students from two universities who created six-second videos using the Vine mobile app to explain or illustrate technological…

The Inclusive Classroom Profile (ICP) Preliminary Findings of Demonstration Study in North Carolina

ERIC Educational Resources Information Center

Soukakou, E.; Winton, P.; West, T.

2012-01-01

The Inclusive Classroom Profile (ICP) was developed in response to a lack of validated instruments designed specifically to measure the quality of inclusive practices, and it is based on research evidence on the effectiveness of specialized instructional strategies for meeting the individual needs of children in inclusive settings (Odom, 2004;…

Measuring Practicing and Prospective Elementary Teachers' Efficacy for Classroom Management: A Preliminary Development and Validation Study

ERIC Educational Resources Information Center

Putman, S. Michael

2013-01-01

Research has shown efficacy exerts a powerful influence on behavior. Classroom management represents one vehicle for demonstrations of these behaviors, yet few instruments focus solely on the measurement of this domain-specific form of efficacy. This research explored the relationship between teacher self-efficacy and classroom management through…

Used Nuclear Fuel Loading and Structural Performance Under Normal Conditions of Transport- Demonstration of Approach and Results on Used Fuel Performance Characterization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adkins, Harold; Geelhood, Ken; Koeppel, Brian

2013-09-30

This document addresses Oak Ridge National Laboratory milestone M2FT-13OR0822015 Demonstration of Approach and Results on Used Nuclear Fuel Performance Characterization. This report provides results of the initial demonstration of the modeling capability developed to perform preliminary deterministic evaluations of moderate-to-high burnup used nuclear fuel (UNF) mechanical performance under normal conditions of storage (NCS) and normal conditions of transport (NCT) conditions. This report also provides results from the sensitivity studies that have been performed. Finally, discussion on the long-term goals and objectives of this initiative are provided.

Satellite Power Systems (SPS) concept definition study exhibit C. Volume 3: Experimental verification definition

NASA Technical Reports Server (NTRS)

1979-01-01

An environmentally oriented microwave technology exploratory research program aimed at reducing the uncertainty associated with microwave power system critical technical issues is described. Topics discussed include: (1) Solar Power Satellite System (SPS) development plan elements; (2) critical technology issues related to the SPS preliminary reference configuration; (3) pilot plant to demonstrate commercial viability of the SPS system; and (4) research areas required to demonstrate feasibility of the SPS system. Progress in the development of advanced GaAs solar cells is reported along with a power distribution subsystem.

Light-controlled cellular internalization and cytotoxicity of nucleic acid-binding agents. Studies in vitro and in zebrafish embryos

PubMed Central

Penas, Cristina; Sánchez, Mateo I.; Guerra-Varela, Jorge; Sanchez-Piñón, Laura; Vázquez, M. Eugenio; Mascareñas, José L.

2016-01-01

We have synthesized oligoarginine conjugates of selected DNA-binding agents (a bisbenzamidine, acridine and thiazole orange) and demonstrated that the DNA binding and cell internalization properties of such conjugates can be inhibited by appending a negatively charged oligoglutamic tail through a photolabile linker. Irradiation with UV light releases the parent octaarginine conjugates, thus restoring their cell internalization and biological activity. Preliminary assays using zebrafish embryos demonstrates the potential of this prodrug strategy for controlling in vivo cytotoxicity. PMID:26534774

Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility.

PubMed

Rzasa, Robert M; Frohn, Michael J; Andrews, Kristin L; Chmait, Samer; Chen, Ning; Clarine, Jeffrey G; Davis, Carl; Eastwood, Heather A; Horne, Daniel B; Hu, Essa; Jones, Adrie D; Kaller, Matthew R; Kunz, Roxanne K; Miller, Silke; Monenschein, Holger; Nguyen, Thomas; Pickrell, Alexander J; Porter, Amy; Reichelt, Andreas; Zhao, Xiaoning; Treanor, James J S; Allen, Jennifer R

2014-12-01

We report the discovery of a novel series of 2-(3-alkoxy-1-azetidinyl) quinolines as potent and selective PDE10A inhibitors. Structure-activity studies improved the solubility (pH 7.4) and maintained high PDE10A activity compared to initial lead compound 3, with select compounds demonstrating good oral bioavailability. X-ray crystallographic studies revealed two distinct binding modes to the catalytic site of the PDE10A enzyme. An ex vivo receptor occupancy assay in rats demonstrated that this series of compounds covered the target within the striatum.

Electrodynamic tether system study: Extended study

NASA Technical Reports Server (NTRS)

1988-01-01

This document is the final report of a study performed by Ball Space Systems Division (BSSD) for the NASA Johnson Space Center under an extension to contract NAS9-17666. The tasks for the extended study were as follows: (1) Define an interface between the Electrodynamic Tether System (ETS) and the Space Station (SS); (2) Identify growth paths for the 100 kW ETS defined in the original study to a 200 kW level of performance; (3) Quantify orbit perturbations caused by cyclic day/night operations of a Plasma Motor/Generator (PMG) on the SS and explore methods of minimizing these effects; (4) Define the analyses, precursor technology, ground tests, and precursor demonstrations leading up to a demonstration mission for an electrodynamic tether system that would be capable of producing maneuvering thrust levels of 25 newtons; and (5) Propose a development schedule for the demonstration mission and preliminary cost estimates.

Methods of Combinatorial Optimization to Reveal Factors Affecting Gene Length

PubMed Central

Bolshoy, Alexander; Tatarinova, Tatiana

2012-01-01

In this paper we present a novel method for genome ranking according to gene lengths. The main outcomes described in this paper are the following: the formulation of the genome ranking problem, presentation of relevant approaches to solve it, and the demonstration of preliminary results from prokaryotic genomes ordering. Using a subset of prokaryotic genomes, we attempted to uncover factors affecting gene length. We have demonstrated that hyperthermophilic species have shorter genes as compared with mesophilic organisms, which probably means that environmental factors affect gene length. Moreover, these preliminary results show that environmental factors group together in ranking evolutionary distant species. PMID:23300345

Public Perceptions and Expectations of the Forensic Use of DNA: Results of a Preliminary Study

ERIC Educational Resources Information Center

Curtis, Cate

2009-01-01

The forensic use of Deoxyribonucleic Acid (DNA) is demonstrating significant success as a crime-solving tool. However, numerous concerns have been raised regarding the potential for DNA use to contravene cultural, ethical, and legal codes. In this article the expectations and level of knowledge of the New Zealand public of the DNA data-bank and…

Role of polyamines in DNA synthesis of Catharanthus roseus cells grown in suspension culture

Treesearch

Rakesh Minocha; Subhash C. Minocha; Atsushi Komamine; Walter C. Shortle

1990-01-01

The requirement for polyamines in the proliferation of cells was first demonstrated in bacteria (3). While significant progress has been made in this field using animal cell cultures, only preliminary studies have been reported with plant tissues. Serafini-Fracassini et al. (9) showed a marked increase in polyamine synthesis early during the G 1 phase, concomitant with...

Development of Artistic Perception in Students of Graphic Design: A Preliminary Report.

ERIC Educational Resources Information Center

Hanson, Glenn

This study is an attempt to determine what level of artistic perception or art taste is brought into the classroom by students in schools of journalism and whether it can be demonstrated that design instruction can raise the level of artistic perception among journalism and advertising students. It was hypothesized that women would score higher in…

Writing implementation research grant proposals: ten key ingredients

PubMed Central

2012-01-01

Background All investigators seeking funding to conduct implementation research face the challenges of preparing a high-quality proposal and demonstrating their capacity to conduct the proposed study. Applicants need to demonstrate the progressive nature of their research agenda and their ability to build cumulatively upon the literature and their own preliminary studies. Because implementation science is an emerging field involving complex and multilevel processes, many investigators may not feel equipped to write competitive proposals, and this concern is pronounced among early stage implementation researchers. Discussion This article addresses the challenges of preparing grant applications that succeed in the emerging field of dissemination and implementation. We summarize ten ingredients that are important in implementation research grants. For each, we provide examples of how preliminary data, background literature, and narrative detail in the application can strengthen the application. Summary Every investigator struggles with the challenge of fitting into a page-limited application the research background, methodological detail, and information that can convey the project’s feasibility and likelihood of success. While no application can include a high level of detail about every ingredient, addressing the ten ingredients summarized in this article can help assure reviewers of the significance, feasibility, and impact of the proposed research. PMID:23062065

Preliminary evaluation of fiber composite reinforcement of truck frame rails

NASA Technical Reports Server (NTRS)

Faddoul, J. R.

1977-01-01

The use of graphite fiber/resin matrix composite to effectively reinforce a standard steel truck frame rail is studied. A preliminary design was made and it was determined that the reinforcement weight could be reduced by a factor of 10 when compared to a steel reinforcement. A section of a 1/3 scale reinforced rail was fabricated to demonstrate low cost manufacturing techniques. The scale rail section was then tested and increased stiffness was confirmed. No evidence of composite fatigue was found after 500,000 cycles to a fiber stress of 34,000 psi. The test specimen failed in bending in a static test at a load 50 percent greater than that predicted for a non-reinforced rail.

An Overview of an Experimental Demonstration Aerotow Program

NASA Technical Reports Server (NTRS)

Murray, James E.; Bowers, Albion H.; Lokos, William A.; Peters, Todd L.; Gera, Joseph

1998-01-01

An overview of an experimental demonstration of aerotowing a delta-wing airplane with low-aspect ratio and relatively high wing loading is presented. Aerotowing of future space launch configurations is a new concept, and the objective of the work described herein is to demonstrate the aerotow operation using an airplane configuration similar to conceptual space launch vehicles. Background information on the use of aerotow for a space launch vehicle is presented, and the aerotow system used in this demonstration is described. The ground tests, analytical studies, and flight planning used to predict system behavior and to enhance flight safety are detailed. The instrumentation suite and flight test maneuvers flown are discussed, preliminary performance is assessed, and flight test results are compared with the preflight predictions.

About vortex-like atomic motion in a loaded single crystal

NASA Astrophysics Data System (ADS)

Dmitriev, A. I.; Nikonov, A. Yu.

2017-12-01

The paper presents a molecular dynamics study of internal stress and atomic displacement redistributions in a preliminary loaded solid. The study demonstrates the possibility of self-organized vortices as dynamic defects of typical size 1-5 nm due to atomic motion in the elastic region at the stage of relaxation. The simulation results agree well with experimental data on strain localization in elastic distortion regions which gives rise to nanodipoles of partial disclinations.

Preliminary Study of Arcjet Neutralization of Hall Thruster Clusters (Postprint)

DTIC Science & Technology

2007-01-18

Clustered Hall thrusters have emerged as a favored choice for extending Hall thruster options to very high powers (50 kW - 150 kW). This paper...examines the possible use of an arcjet to neutralize clustered Hall thrusters, as the hybrid arcjet- Hall thruster concept can fill a performance niche...and helium, and then demonstrate the first successful operation of a low power Hall thruster -arcjet neutralizer package. In the surrogate anode studies

A technology demonstrator for development of ultra-lightweight, large aperture, deployable telescope for space applications

NASA Astrophysics Data System (ADS)

Zuccaro Marchi, Alessandro; Gambicorti, Lisa; Simonetti, Francesca; Salinari, Piero; Lisi, Franco; Bursi, Alessandro; Olivier, Massimiliano; Gallieni, Daniele

2017-11-01

This work presents the latest results of new technological concepts for large aperture, lightweight telescopes using thin deployable active mirrors. The study is originally addressed to a spaceborne DIAL (Differential Absorption Lidar) at 935.5 nm for the measurement of water vapour profile in atmosphere, as an output of an ESA contract (whose preliminary results were presented at ICSO 2006). The high versatility of these concepts allows to exploit the presented technology for any project willing to consider large aperture, segmented lightweight telescopes. A possible scientific application is for Ultra High Energy Cosmic Rays detection through the fluorescence traces in atmosphere and diffused Cerenkov signals observation via a Schmidt-like spaceborne LEO telescope with large aperture, wide Field of View (FOV) and low f/#. A technology demonstrator has been manufactured and tested in order to investigate two project critical areas identified during the preliminary design: the performances of the long-stroke actuators used to implement the mirror active control and the mirror survivability to launch. In particular, this breadboard demonstrates at first that the mirror actuators are able to control with the adequate accuracy the surface shape and to recover a deployment error with their long stroke; secondly, the mirror survivability has been demonstrated using an electrostatic locking between mirror and backplane able to withstand without failure a vibration test representative of the launch environment.

Study of Mouthguard Design for Endurance and Air-Flow Intake

NASA Astrophysics Data System (ADS)

Zaman, I.; Rozlan, S. A. M.; Manshoor, B.; Ngali, M. Z.; Khalid, A.; Amin, N. A. M.

2017-08-01

Mouthguard is one of the important device for athletes. Wearing a mouthguard is a must to prevent them from any orofacial injuries occurs during their sport activities. Therefore, to make sure it is safe and comfort, a study on the mouthguard design is carried out to investigate the performance of the mouthguard, in term of stress distribution and air flow path by improving the pressure difference between ambient and the oral cavity pressure. A preliminary design has been study to simulate its total deformation and stress, in terms of Von Mises Stress by using ANSYS 15.0 Workbench. From the results, the critical parts are identified on the preliminary design and later being used to improve the design to the new one. By increasing the thickness of the preliminary design, the total deformation has been decreased for about 0.20 mm to 0.16 mm for the exerted external forces ranging from 50-500 N, whereas, for internal forces ranging from 100-600 N have reduced deformation from 0.24 mm to 1.44 mm. The simulation process is then followed by the air flow study in the oral cavity with an open mouth about 0.5 mm when the athlete is doing exercise with speed 4.43 m/s of air flow into a mouth. The finding indicates that the modified mouthguard has large value of velocity streamline compared to the preliminary design which is supported by significant pressure difference of 401.86 Pa, compared to 140.09 Pa of the preliminary design. Velocity stream line also shows that the higher speeds occur in the near mouthguard, that is, between the bottom surfaces of the mouthguard and the lower teeth. The results demonstrated that the thicker the mouthguard, the better it is for prevention but less in air flow distribution into the oral cavity.

Development and Feasibility of a Virtual Reality Task for the Cognitive Assessment of Older Adults: The ECO-VR.

PubMed

Oliveira, Camila R; Lopes Filho, Brandel José P; Sugarman, Michael A; Esteves, Cristiane S; Lima, Margarida Maria B M P; Moret-Tatay, Carmen; Irigaray, Tatiana Q; Argimon, Irani Iracema L

2016-12-13

Cognitive assessment with virtual reality (VR) may have superior ecological validity for older adults compared to traditional pencil-and-paper cognitive assessment. However, few studies have reported the development of VR tasks. The aim of this study was to present the development, feasibility, content validity, and preliminary evidence of construct validity of an ecological task of cognitive assessment for older adults in VR (ECO-VR). The tasks were prepared based on theoretical and clinical backgrounds. We had 29 non-expert judges identify virtual visual stimuli and three-dimensional scenarios, and five expert judges assisted with content analysis and developing instructions. Finally, six older persons participated in three pilot studies and thirty older persons participated in the preliminary study to identify construct validity evidence. Data were analyzed by descriptive statistics and partial correlation. Target stimuli and three-dimensional scenarios were judged adequate and the content analysis demonstrated that ECO-VR evaluates temporo-spatial orientation, memory, language and executive functioning. We made significant changes to the instructions after the pilot studies to increase comprehensibility and reduce the completion time. The total score of ECO-VR was positively correlated mainly with performance in executive function (r = .172, p < .05) and memory tests (r = .488, p ≤ .01). The ECO-VR demonstrated feasibility for cognitive assessment in older adults, as well as content and construct validity evidences.

Elucidating the relationship between work attention performance and emotions arising from listening to music.

PubMed

Shih, Yi-Nuo; Chien, Wei-Hsien; Chiang, Han-Sun

2016-10-17

In addition to demonstrating that human emotions improve work attention performance, numerous studies have also established that music alters human emotions. Given the pervasiveness of background music in the workplace, exactly how work attention, emotions and music listening are related is of priority concern in human resource management. This preliminary study investigates the relationship between work attention performance and emotions arising from listening to music. Thirty one males and 34 females, ranging from 20-24 years old, participated in this study following written informed consent. A randomized controlled trial (RCT) was performed in this study, which consisted of six steps and the use of the standard attention test and emotion questionnaire. Background music with lyrics adversely impacts attention performance more than that without lyrics. Analysis results also indicate that listeners self-reported feeling "loved" while music played that implied a higher score on their work-attention performance. Moreover, a greater ability of music to make listeners feel sad implied a lower score on their work-attention performance. Results of this preliminary study demonstrate that background music in the workplace should focus mainly on creating an environment in which listeners feel loved or taken care and avoiding music that causes individuals to feel stressed or sad. We recommend that future research increase the number of research participants to enhance the applicability and replicability of these findings.

Preliminary study of a millimeter wave FMCW InSAR for UAS indoor navigation.

PubMed

Scannapieco, Antonio F; Renga, Alfredo; Moccia, Antonio

2015-01-22

Small autonomous unmanned aerial systems (UAS) could be used for indoor inspection in emergency missions, such as damage assessment or the search for survivors in dangerous environments, e.g., power plants, underground railways, mines and industrial warehouses. Two basic functions are required to carry out these tasks, that is autonomous GPS-denied navigation with obstacle detection and high-resolution 3Dmapping with moving target detection. State-of-the-art sensors for UAS are very sensitive to environmental conditions and often fail in the case of poor visibility caused by dust, fog, smoke, flames or other factors that are met as nominal mission scenarios when operating indoors. This paper is a preliminary study concerning an innovative radar sensor based on the interferometric Synthetic Aperture Radar (SAR) principle, which has the potential to satisfy stringent requirements set by indoor autonomous operation. An architectural solution based on a frequency-modulated continuous wave (FMCW) scheme is proposed after a detailed analysis of existing compact and lightweight SAR. A preliminary system design is obtained, and the main imaging peculiarities of the novel sensor are discussed, demonstrating that high-resolution, high-quality observation of an assigned control volume can be achieved.

Preliminary Study of a Millimeter Wave FMCW InSAR for UAS Indoor Navigation

PubMed Central

Scannapieco, Antonio F.; Renga, Alfredo; Moccia, Antonio

2015-01-01

Small autonomous unmanned aerial systems (UAS) could be used for indoor inspection in emergency missions, such as damage assessment or the search for survivors in dangerous environments, e.g., power plants, underground railways, mines and industrial warehouses. Two basic functions are required to carry out these tasks, that is autonomous GPS-denied navigation with obstacle detection and high-resolution 3D mapping with moving target detection. State-of-the-art sensors for UAS are very sensitive to environmental conditions and often fail in the case of poor visibility caused by dust, fog, smoke, flames or other factors that are met as nominal mission scenarios when operating indoors. This paper is a preliminary study concerning an innovative radar sensor based on the interferometric Synthetic Aperture Radar (SAR) principle, which has the potential to satisfy stringent requirements set by indoor autonomous operation. An architectural solution based on a frequency-modulated continuous wave (FMCW) scheme is proposed after a detailed analysis of existing compact and lightweight SAR. A preliminary system design is obtained, and the main imaging peculiarities of the novel sensor are discussed, demonstrating that high-resolution, high-quality observation of an assigned control volume can be achieved. PMID:25621606

Online Activities for Enhancing Sex Education Curricula: Preliminary Evidence on the Effectiveness of the Abstinence and Contraception Education Storehouse

PubMed Central

Raghupathy, Shobana; Klein, Charles; Card, Josefina

2013-01-01

The purpose of this research was to conduct a preliminary evaluation of the Abstinence and Contraception Education Storehouse (ACES), a digital, classroom-based resource designed to supplement existing sex education curricula with highly interactive materials such as video clips, multimedia polls and quizzes, and audiovisual demonstrations. 335 students ages 14–19 were randomly assigned to an ACES–based (treatment) or a standard (control) sex education curriculum. Data were collected at the onset of the intervention and 3-months after the completion of the intervention. Preliminary results were highly encouraging, with ACES participants who were sexually initiated at baseline reporting at the 3-month follow-up significant reductions in the number of times they had sex in the past four weeks. Both sexually initiated and non-sexually initiated youth who experienced the ACES curriculum also demonstrated greater intent to abstain from the sex during the follow-up period than those in the control group. PMID:24078799

Multidisciplinary optimization of controlled space structures with global sensitivity equations

NASA Technical Reports Server (NTRS)

Padula, Sharon L.; James, Benjamin B.; Graves, Philip C.; Woodard, Stanley E.

1991-01-01

A new method for the preliminary design of controlled space structures is presented. The method coordinates standard finite element structural analysis, multivariable controls, and nonlinear programming codes and allows simultaneous optimization of the structures and control systems of a spacecraft. Global sensitivity equations are a key feature of this method. The preliminary design of a generic geostationary platform is used to demonstrate the multidisciplinary optimization method. Fifteen design variables are used to optimize truss member sizes and feedback gain values. The goal is to reduce the total mass of the structure and the vibration control system while satisfying constraints on vibration decay rate. Incorporating the nonnegligible mass of actuators causes an essential coupling between structural design variables and control design variables. The solution of the demonstration problem is an important step toward a comprehensive preliminary design capability for structures and control systems. Use of global sensitivity equations helps solve optimization problems that have a large number of design variables and a high degree of coupling between disciplines.

King County Metro Battery Electric Bus Demonstration: Preliminary Project Results

DOE Office of Scientific and Technical Information (OSTI.GOV)

The U.S. Federal Transit Administration (FTA) funds a variety of research projects that support the commercialization of zero-emission bus technology. To evaluate projects funded through these programs, FTA has enlisted the help of the National Renewable Energy Laboratory (NREL) to conduct third-party evaluations of the technologies deployed under the FTA programs. NREL works with the selected agencies to evaluate the performance of the zero-emission buses compared to baseline conventional buses in similar service. The evaluation effort will advance the knowledge base of zero-emission technologies in transit bus applications and provide 'lessons learned' to aid other fleets in incrementally introducing nextmore » generation zero-emission buses into their operations. This report provides preliminary performance evaluation results from a demonstration of three zero-emission battery electric buses at King County Metro in King County, Washington. NREL developed this preliminary results report to quickly disseminate evaluation results to stakeholders. Detailed evaluation results will be published in future reports.« less

Cascade Optimization Strategy with Neural Network and Regression Approximations Demonstrated on a Preliminary Aircraft Engine Design

NASA Technical Reports Server (NTRS)

Hopkins, Dale A.; Patnaik, Surya N.

2000-01-01

A preliminary aircraft engine design methodology is being developed that utilizes a cascade optimization strategy together with neural network and regression approximation methods. The cascade strategy employs different optimization algorithms in a specified sequence. The neural network and regression methods are used to approximate solutions obtained from the NASA Engine Performance Program (NEPP), which implements engine thermodynamic cycle and performance analysis models. The new methodology is proving to be more robust and computationally efficient than the conventional optimization approach of using a single optimization algorithm with direct reanalysis. The methodology has been demonstrated on a preliminary design problem for a novel subsonic turbofan engine concept that incorporates a wave rotor as a cycle-topping device. Computations of maximum thrust were obtained for a specific design point in the engine mission profile. The results (depicted in the figure) show a significant improvement in the maximum thrust obtained using the new methodology in comparison to benchmark solutions obtained using NEPP in a manual design mode.

Online Activities for Enhancing Sex Education Curricula: Preliminary Evidence on the Effectiveness of the Abstinence and Contraception Education Storehouse.

PubMed

Raghupathy, Shobana; Klein, Charles; Card, Josefina

2013-01-01

The purpose of this research was to conduct a preliminary evaluation of the Abstinence and Contraception Education Storehouse (ACES), a digital, classroom-based resource designed to supplement existing sex education curricula with highly interactive materials such as video clips, multimedia polls and quizzes, and audiovisual demonstrations. 335 students ages 14-19 were randomly assigned to an ACES-based (treatment) or a standard (control) sex education curriculum. Data were collected at the onset of the intervention and 3-months after the completion of the intervention. Preliminary results were highly encouraging, with ACES participants who were sexually initiated at baseline reporting at the 3-month follow-up significant reductions in the number of times they had sex in the past four weeks. Both sexually initiated and non-sexually initiated youth who experienced the ACES curriculum also demonstrated greater intent to abstain from the sex during the follow-up period than those in the control group.

Diversity of Alticinae in Oaxaca, Mexico: A preliminary study (Coleoptera, Chrysomelidae)1

PubMed Central

Furth, David G.

2013-01-01

Abstract This is a preliminary study of the diversity of the Flea Beetles (Alticinae) of the Mexican state of Oaxaca based on fieldwork by the author in 1991, 1997, and 2010, the literature, and specimens in several institutional collections. The number of genera and species for Mexico as well as for Oaxaca increased significantly from previous studies. There are now 625 species in 90 genera recorded from Mexico with 275 species in 68 genera recorded from Oaxaca. There are 113 species known only from the state of Oaxaca and another 38 species known only from Oaxaca and the surrounding states. Oaxaca has a relatively high diversity as well as a high percentage of endemism. This study also demonstrates the effects of how even a small amount of fieldwork together with extracting specimen data from institutional collections can significantly increase the total faunistic and diversity knowledge of an area. A complete list of the genera and species known from Oaxaca is included. PMID:24163579

A preliminary demonstration of "virtual warehousing" and cross-docking technique with active RFID combined with asset tracking equipment.

DOT National Transportation Integrated Search

2010-11-01

The University of Denvers Intermodal Transportation Institute and System Planning : Corporations GlobalTrak system have successfully demonstrated the integration of GPS : tracking and active RFID monitoring of simulated cargo of pallet and cart...

Crystallization and preliminary X-ray diffraction studies of an RNA aptamer in complex with the human IgG Fc fragment

PubMed Central

Sugiyama, Shigeru; Nomura, Yusuke; Sakamoto, Taiichi; Kitatani, Tomoya; Kobayashi, Asako; Miyakawa, Shin; Takahashi, Yoshinori; Adachi, Hiroaki; Takano, Kazufumi; Murakami, Satoshi; Inoue, Tsuyoshi; Mori, Yusuke; Nakamura, Yoshikazu; Matsumura, Hiroyoshi

2008-01-01

Aptamers, which are folded DNA or RNA molecules, bind to target molecules with high affinity and specificity. An RNA aptamer specific for the Fc fragment of human immunoglobulin G (IgG) has recently been identified and it has been demonstrated that an optimized 24-nucleotide RNA aptamer binds to the Fc fragment of human IgG and not to other species. In order to clarify the structural basis of the high specificity of the RNA aptamer, it was crystallized in complex with the Fc fragment of human IgG1. Preliminary X-ray diffraction studies revealed that the crystals belonged to the orthorhombic space group P21212, with unit-cell parameters a = 83.7, b = 107.2, c = 79.0 Å. A data set has been collected to 2.2 Å resolution. PMID:18931441

Researches on Preliminary Chemical Reactions in Spark-Ignition Engines

NASA Technical Reports Server (NTRS)

Muehlner, E.

1943-01-01

Chemical reactions can demonstrably occur in a fuel-air mixture compressed in the working cylinder of an Otto-cycle (spark ignition) internal-combustion engine even before the charge is ignited by the flame proceeding from the sparking plug. These are the so-called "prelinminary reactions" ("pre-flame" combustion or oxidation), and an exact knowledge of their characteristic development is of great importance for a correct appreciation of the phenomena of engine-knock (detonation), and consequently for its avoidance. Such reactions can be studied either in a working engine cylinder or in a combustion bomb. The first method necessitates a complicated experimental technique, while the second has the disadvantage of enabling only a single reaction to be studied at one time. Consequently, a new series of experiments was inaugurated, conducted in a motored (externally-driven) experimental engine of mixture-compression type, without ignition, the resulting preliminary reactions being detectable and measurable thermometrically.

Preliminary identification of potential markets for off-grid electrification: tool development and a case study of Ghana

NASA Astrophysics Data System (ADS)

Descoqs, Benoit; Bhattacharyya, Subhes

2018-02-01

With more than one billion people lacking access to electricity in the world, ensuring universal access to electricity by 2030 remains a major challenge which cannot be left to the government initiatives alone. Access to local information and identification of potential areas for investment can be a challenge for investors. This paper provides a tool for preliminary assessment of potential markets for off-grid electrification in developing countries and applies this to Ghana to demonstrate its applicability. A multi-criteria approach is used to rank the districts according to the overall potential and the best markets and least favourable areas for investment are identified. The tool offers flexibility to include new inputs to the analysis and the factor weights can be adjusted as appropriate. The case study shows that the tool can effectively identify potential areas from a list of candidates and offers support to analysts.

Gone But Not Forgotten: The Aeolian Modification of Fluvial Surfaces on Mars: Preliminary Results from Central Australia

NASA Technical Reports Server (NTRS)

Bourke, M. C.

2003-01-01

MOC images indicate that aeolian ridges may mask and even obliterate primary depositional surfaces on Mars. This modification increases the difficulty in mapping the recent geological history of the planet. An analogue study in central Australia demonstrates how patterns in aeolian dunes, formed over abandoned fluvial surfaces, can be used to detect buried fluvial features.

Preliminary design study of advanced composite blade and hub and nonmechanical control system for the tilt-rotor aircraft. Volume 2: Project planning data

NASA Technical Reports Server (NTRS)

1980-01-01

Project planning data for a rotor and control system procurement and testing program for modifications to the XV-15 tilt-rotor research demonstrator aircraft is presented. The design, fabrication, and installation of advanced composite blades compatible with the existing hub, an advanced composite hub, and a nonmechanical control system are required.

Development of injector/amplifier XUV lasers and initial studies of ultrashort pulse UV multiphoton ionization

NASA Astrophysics Data System (ADS)

Key, Michael H.; Blyth, W. J.; Cairns, Gerald F.; Damerell, A. R.; Dangor, A. E.; Danson, Colin N.; Evans, J. M.; Hirst, Graeme J.; Holden, M.; Hooker, Chris J.; Houliston, J. R.; Krishnan, J.; Lewis, Ciaran L. S.; Lister, J. M. D.; MacPhee, Andrew G.; Najmudin, Z.; Neely, David; Norreys, Peter A.; Offenberger, Allen A.; Osvay, Karoly; Pert, Geoffrey J.; Preston, S. G.; Ramsden, Stuart A.; Ross, Ian N.; Sibbett, Wilson; Tallents, Gregory J.; Smith, C.; Wark, Justin S.; Zhang, Jie

1994-02-01

An injector-amplifier architecture for XUV lasers has been developed and demonstrated using the Ge XXIII collisional laser. Results are described for injection into single and double plasma amplifiers. Prismatic lens-like and higher order aberrations in the amplifier are considered. Limitations on ultimate brightness are discussed and also scaling to operation at shorter wavelengths. A preliminary study has been made of UV multiphoton ionization using 300 fs pulses at high intensity.

Youth and Minority Unemployment: A Study Prepared for the Use of the Joint Economic Committee, Congress of the United States, Ninety-fifth Congress, First Session. Joint Committee Print.

ERIC Educational Resources Information Center

Williams, Walter E.

In this study, the problem of youth and minority employment in the United States is analyzed. The scope and character of the problem is defined. To demonstrate worsening trends, data from selected years since 1946 are presented. A preliminary explanation of supply and demand in the labor market is offered. A number of the causes of youth…

Noise robustness of a combined phase retrieval and reconstruction method for phase-contrast tomography.

PubMed

Kongskov, Rasmus Dalgas; Jørgensen, Jakob Sauer; Poulsen, Henning Friis; Hansen, Per Christian

2016-04-01

Classical reconstruction methods for phase-contrast tomography consist of two stages: phase retrieval and tomographic reconstruction. A novel algebraic method combining the two was suggested by Kostenko et al. [Opt. Express21, 12185 (2013)OPEXFF1094-408710.1364/OE.21.012185], and preliminary results demonstrated improved reconstruction compared with a given two-stage method. Using simulated free-space propagation experiments with a single sample-detector distance, we thoroughly compare the novel method with the two-stage method to address limitations of the preliminary results. We demonstrate that the novel method is substantially more robust toward noise; our simulations point to a possible reduction in counting times by an order of magnitude.

A multicontext approach to promoting transfer of strategy use and self regulation after brain injury: An exploratory study.

PubMed

Toglia, Joan; Johnston, Mark V; Goverover, Yael; Dain, Barry

2010-01-01

Persons with brain injury frequently demonstrate decreased ability to monitor and apply strategies learned in treatment to everyday situations. The aim of this study is to refine, explore and provide preliminary testing of the multicontext approach in promoting strategy use across situations and increasing self-regulation, awareness and functional performance. This study used a single-subject design with repeated measures pre- and post-intervention, with data analysed descriptively and graphically. Four persons with difficulty following multi-step directions, 3-5 years post-TBI, received a nine session intervention programme. Outcome measures included the Awareness Questionnaire, Self-Regulation Skills Interview, Behavior Rating Inventory of Executive Function, Multiple Errands Test and an Executive Function Performance Test sub-task. The process of change within each treatment session was examined with strategy and awareness ratings. All participants demonstrated positive changes in self-regulatory skills and strategy use that was observed across tasks. As expected, general awareness of deficits remained unchanged. Examination of individual participants revealed important, varying patterns of change in strategy use, learning transfer and self-awareness across intervention. Results provide preliminary support for the feasibility and efficacy of the multicontext approach in promoting transfer of strategy use to enhance functional performance and selective aspects of awareness. Further investigation, including a larger controlled study, is needed to confirm or limit these observations.

Test and evaluation of Apollo 14 composite casting demonstration specimens and flight and control samples

NASA Technical Reports Server (NTRS)

Fabiniak, R. C.; Fabiniak, T. J.

1971-01-01

The results of experiments 1, 2, and 10 of the Apollo 14 composite casting demonstration are discussed. The purpose of the demonstration, with regard to samples 1 and 2, was to obtain preliminary data on the liquid phase sintering process in a weightless environment. With regard to sample 10, the purpose was to obtain preliminary information on how to achieve uniform dispersion of dense particles on a metal matrix by employing shaking modes or forces in the system when the metal matrix is molten. Results of the demonstrations were interpreted in a quantitative and qualitative manner. For experiment 1 it was found that the tungsten particles were redistributed more uniformly in the flight sample than in the control sample. Experiment 2 results indicate that complete melting may not have occured and thus a high degree of significance cannot be associated with the qualitative results relating to particle redistribution data. The particle-matrix system of experiment 10 was found to be nonwetting.

Integration of a CAD System Into an MDO Framework

NASA Technical Reports Server (NTRS)

Townsend, J. C.; Samareh, J. A.; Weston, R. P.; Zorumski, W. E.

1998-01-01

NASA Langley has developed a heterogeneous distributed computing environment, called the Framework for Inter-disciplinary Design Optimization, or FIDO. Its purpose has been to demonstrate framework technical feasibility and usefulness for optimizing the preliminary design of complex systems and to provide a working environment for testing optimization schemes. Its initial implementation has been for a simplified model of preliminary design of a high-speed civil transport. Upgrades being considered for the FIDO system include a more complete geometry description, required by high-fidelity aerodynamics and structures codes and based on a commercial Computer Aided Design (CAD) system. This report presents the philosophy behind some of the decisions that have shaped the FIDO system and gives a brief case study of the problems and successes encountered in integrating a CAD system into the FEDO framework.

Feasibility, Acceptability, and Preliminary Effectiveness of a Peer-Delivered and Technology Supported Self-Management Intervention for Older Adults with Serious Mental Illness.

PubMed

Fortuna, Karen L; DiMilia, Peter R; Lohman, Matthew C; Bruce, Martha L; Zubritsky, Cynthia D; Halaby, Mitch R; Walker, Robert M; Brooks, Jessica M; Bartels, Stephen J

2018-06-01

To assess the feasibility, acceptability, and preliminary effectiveness of a peer-delivered and technology supported integrated medical and psychiatric self-management intervention for older adults with serious mental illness. Ten older adults with serious mental illness (i.e., schizophrenia, schizoaffective disorder, bipolar disorder, or major depressive disorder) and medical comorbidity (i.e., cardiovascular disease, obesity, diabetes, chronic obstructive pulmonary disease, hypertension, and/or high cholesterol) aged 60 years and older received the PeerTECH intervention in their homes. Three certified peer specialists were trained to deliver PeerTECH. Data were collected at baseline, one-month, and three-month. The pilot study demonstrated that a three-month, peer-delivered and technology-supported integrated medical and psychiatric self-management intervention ("PeerTECH") was experienced by peer specialists and participants as feasible and acceptable. PeerTECH was associated with statistically significant improvements in psychiatric self-management. In addition, pre/post, non-statistically significant improvements were observed in self-efficacy for managing chronic health conditions, hope, quality of life, medical self-management skills, and empowerment. This pre/post pilot study demonstrated it is possible to train peers to use technology to deliver an integrated psychiatric and medical self-management intervention in a home-based setting to older adults with serious mental illness with fidelity. These findings provide preliminary evidence that a peer-delivered and technology-supported intervention designed to improve medical and psychiatric self-management is feasible, acceptable, and is potentially associated with improvements in psychiatric self-management, self-efficacy for managing chronic health conditions, hope, quality of life, medical self-management skills, and empowerment with older adults with serious mental illness and chronic health conditions.

Strategic avionics technology definition studies. Subtask 3-1A: Electrical Actuation (ELA) systems

NASA Technical Reports Server (NTRS)

Lum, Ben T. F.; Pond, Charles; Dermott, William

1993-01-01

This interim report presents the preliminary results of an electrical actuation (ELA) system study (subtask TA3-1A) to support the NASA strategic avionics technology definition studies. The final report of this ELA study is scheduled for September 30, 1993. The topics are presented in viewgraph form and include the following ELA technology demonstration testing; ELA system baseline; power and energy requirements for shuttle effector systems; power efficiency and losses of ELA effector systems; and power and energy requirements for ELA power sources.

Study of statistical coding for digital TV

NASA Technical Reports Server (NTRS)

Gardenhire, L. W.

1972-01-01

The results are presented for a detailed study to determine a pseudo-optimum statistical code to be installed in a digital TV demonstration test set. Studies of source encoding were undertaken, using redundancy removal techniques in which the picture is reproduced within a preset tolerance. A method of source encoding, which preliminary studies show to be encouraging, is statistical encoding. A pseudo-optimum code was defined and the associated performance of the code was determined. The format was fixed at 525 lines per frame, 30 frames per second, as per commercial standards.

GRC-2010-C-01237

NASA Image and Video Library

2006-03-29

Fiber-Reinforced-Foam (FRF) Core Composite Sandwich Panel Concept for Advanced Composites Technologies Project - Preliminary Manufacturing Demonstration Articles for Ares V Payload Shroud Barrel Acreage Structure

GRC-2010-C-01234

NASA Image and Video Library

2006-03-29

Fiber-Reinforced-Foam (FRF) Core Composite Sandwich Panel Concept for Advanced Composites Technologies Project - Preliminary Manufacturing Demonstration Articles for Ares V Payload Shroud Barrel Acreage Structure

GRC-2010-C-01233

NASA Image and Video Library

2006-03-29

Fiber-Reinforced-Foam (FRF) Core Composite Sandwich Panel Concept for Advanced Composites Technologies Project - Preliminary Manufacturing Demonstration Articles for Ares V Payload Shroud Barrel Acreage Structure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goltz, M.N.; Carrothers, T.J.; Hopkins, G.D.

A full-scale study of in situ bioremediation is being planned for implementation at a trichloroethylene (TCE) contaminated site at Edwards Air Force Base. To support the demonstration, laboratory studies of sorption and biodegradation were performed. Column studies conducted with TCE and Edwards aquifer material determined the sorption distribution coefficient to be 0.1 millileters per gram, corresponding to a 1.5 retardation factor. Edwards aquifer material from four different depths was used to study cometabolic TCE biodegradation in the presence of toluene under aerobic conditions. The studies showed steady state TCE removal of greater than or equal to 85% in the microcosms.more » A base line simulation was performed using a computer model which incorporated all significant flow and transport processes. The simulation shows how TCE mass declines in both the dissolved and sorbed phases over the four months planned for the demonstration. Based on these preliminary studies, it appears that the planned operation of the bioremediation system can be expected to result in observable decreases in TCE mass and concentration at the Edwards demonstration site.« less

Teaching young people who are blind and have autism to make requests using a variation on the picture exchange communication system with tactile symbols: a preliminary investigation.

PubMed

Lund, Shelley K; Troha, Jeanette M

2008-04-01

This study used a single-subject multiple baseline across participants design to evaluate the effectiveness of a modified picture exchange communication system (PECS) teaching protocol with tactile symbols. Three students (two male, one female) aged 12-17 years who had autism and were blind participated in the study. The instructional program involved three phases. First, each participant learned to exchange a tactile symbol with his/her communication partner to request a preferred item/activity. Second, the distance between the communication partner and the participant was increased. Third, the participants were required to discriminate between two dissimilar tactile symbols. One out of three participants completed all phases of the instructional program. Although the other two participants did not complete the program, they demonstrated improvement from baseline responding rates. This study provided preliminary results that using tactile symbols with strategies from PECS may be an effective method to teach requesting to youth who are blind and have autism.

Preliminary Results, Analysis, and Overview of Part-1 of the GOLD Experiment

NASA Technical Reports Server (NTRS)

Wilson, K. E.; Jeganathan, M.

1996-01-01

The Ground/Orbiter Lasercomm Demonstration (GOLD) is an optical communications demonstraton between the Japanese Engineering Test Satellite (ETS-VI) and an optical ground transmitting and receiving station at the Table Mountain Facility. GOLD was an experiment that demonstrated real-time international collaboration.

The Majorana Demonstrator Status and Preliminary Results

DOE PAGES

Yu, C. -H.; Alvis, S. I.; Arnquist, I. J.; ...

2018-01-01

The MAJORANA Collaboration is using an array of high-purity Ge detectors to search for neutrinoless double-beta decay in 76Ge. Searches for neutrinoless double-beta decay are understood to be the only viable experimental method for testing the Majorana nature of the neutrino. Observation of this decay would imply violation of lepton number, that neutrinos are Majorana in nature, and provide information on the neutrino mass. The MAJORANA DEMONSTRATOR comprises 44.1 kg of p-type point-contact Ge detectors (29.7 kg enriched in 76Ge) surrounded by a low-background shield system. The experiment achieved a high efficiency of converting raw Ge material to detectors andmore » an unprecedented detector energy resolution of 2.5 keV FWHM at Q ββ. The MAJORANA collaboration began taking physics data in 2016. Here, this paper summarizes key construction aspects of the Demonstrator and shows preliminary results from initial data.« less

The Majorana Demonstrator Status and Preliminary Results

NASA Astrophysics Data System (ADS)

Yu, C.-H.; Alvis, S. I.; Arnquist, I. J.; Avignone, F. T.; Barabash, A. S.; Barton, C. J.; Bertrand, F. E.; Bode, T.; Brudanin, V.; Busch, M.; Buuck, M.; Caldwell, T. S.; Chan, Y.-D.; Christofferson, C. D.; Chu, P.-H.; Cuesta, C.; Detwiler, J. A.; Dunagan, C.; Efremenko, Yu; Ejiri, H.; Elliott, S. R.; Gilliss, T.; Giovanetti, G. K.; Green, M.; Gruszko, J.; Guinn, I. S.; Guiseppe, V. E.; Haufe, C. R.; Hehn, L.; Henning, R.; Hoppe, E. W.; Howe, M. A.; Keeter, K. J.; Kidd, M. F.; Konovalov, S. I.; Kouzes, R. T.; Lopez, A. M.; Martin, R. D.; Massarczyk, R.; Meijer, S. J.; Mertens, S.; Myslik, J.; Othman, G.; Pettus, W.; Poon, A. W. P.; Radford, D. C.; Rager, J.; Reine, A. L.; Rielage, K.; Ruof, N. W.; Shanks, B.; Shirchenko, M.; Suriano, A. M.; Tedeschi, D.; Varner, R. L.; Vasilyev, S.; Vetter, K.; Vorren, K.; White, B. R.; Wilkerson, J. F.; Wiseman, C.; Xu, W.; Yakushev, E.; Yumatov, V.; Zhitnikov, I.; Zhu, B. Z.

2018-05-01

The MAJORANA Collaboration is using an array of high-purity Ge detectors to search for neutrinoless double-beta decay in 76Ge. Searches for neutrinoless double-beta decay are understood to be the only viable experimental method for testing the Majorana nature of the neutrino. Observation of this decay would imply violation of lepton number, that neutrinos are Majorana in nature, and provide information on the neutrino mass. The MAJORANA DEMONSTRATOR comprises 44.1 kg of p-type point-contact Ge detectors (29.7 kg enriched in 76Ge) surrounded by a low-background shield system. The experiment achieved a high efficiency of converting raw Ge material to detectors and an unprecedented detector energy resolution of 2.5 keV FWHM at Qββ. The MAJORANA collaboration began taking physics data in 2016. This paper summarizes key construction aspects of the Demonstrator and shows preliminary results from initial data.

The Majorana Demonstrator Status and Preliminary Results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yu, C. -H.; Alvis, S. I.; Arnquist, I. J.

The MAJORANA Collaboration is using an array of high-purity Ge detectors to search for neutrinoless double-beta decay in 76Ge. Searches for neutrinoless double-beta decay are understood to be the only viable experimental method for testing the Majorana nature of the neutrino. Observation of this decay would imply violation of lepton number, that neutrinos are Majorana in nature, and provide information on the neutrino mass. The MAJORANA DEMONSTRATOR comprises 44.1 kg of p-type point-contact Ge detectors (29.7 kg enriched in 76Ge) surrounded by a low-background shield system. The experiment achieved a high efficiency of converting raw Ge material to detectors andmore » an unprecedented detector energy resolution of 2.5 keV FWHM at Q ββ. The MAJORANA collaboration began taking physics data in 2016. Here, this paper summarizes key construction aspects of the Demonstrator and shows preliminary results from initial data.« less

Preliminary results toward injection locking of an incoherent laser array

NASA Technical Reports Server (NTRS)

Daher, J.

1986-01-01

The preliminary results of phase locking an incoherent laser array to a master source in an attempt to achieve coherent operation are presented. The techniques necessary to demonstrate phase locking are described along with some topics for future consideration. As expected, the results obtained suggest that injection locking of an array, where the spacing between adjacent longitudinal modes of its elements is significantly larger than the locking bandwidth, may not be feasible.

Simulation studies of multiple large wind turbine generators on a utility network

NASA Technical Reports Server (NTRS)

Gilbert, L. J.; Triezenberg, D. M.

1979-01-01

The potential electrical problems that may be inherent in the inertia of clusters of wind turbine generators and an electric utility network were investigated. Preliminary and limited results of an analog simulation of two MOD-2 wind generators tied to an infinite bus indicate little interaction between the generators and between the generators and the bus. The system demonstrated transient stability for the conditions considered.

Zinc-catalyzed allenylations of aldehydes and ketones.

PubMed

Fandrick, Daniel R; Saha, Jaideep; Fandrick, Keith R; Sanyal, Sanjit; Ogikubo, Junichi; Lee, Heewon; Roschangar, Frank; Song, Jinhua J; Senanayake, Chris H

2011-10-21

The general zinc-catalyzed allenylation of aldehydes and ketones with an allenyl boronate is presented. Preliminary mechanistic studies support a kinetically controlled process wherein, after a site-selective B/Zn exchange to generate a propargyl zinc intermediate, the addition to the electrophile effectively competes with propargyl-allenyl zinc equilibration. The utility of the methodology was demonstrated by application to a rhodium-catalyzed [4+2] cycloaddition. © 2011 American Chemical Society

Development of intelligent model for personalized guidance on wheelchair tilt and recline usage for people with spinal cord injury: methodology and preliminary report.

PubMed

Fu, Jicheng; Jones, Maria; Jan, Yih-Kuen

2014-01-01

Wheelchair tilt and recline functions are two of the most desirable features for relieving seating pressure to decrease the risk of pressure ulcers. The effective guidance on wheelchair tilt and recline usage is therefore critical to pressure ulcer prevention. The aim of this study was to demonstrate the feasibility of using machine learning techniques to construct an intelligent model to provide personalized guidance to individuals with spinal cord injury (SCI). The motivation stems from the clinical evidence that the requirements of individuals vary greatly and that no universal guidance on tilt and recline usage could possibly satisfy all individuals with SCI. We explored all aspects involved in constructing the intelligent model and proposed approaches tailored to suit the characteristics of this preliminary study, such as the way of modeling research participants, using machine learning techniques to construct the intelligent model, and evaluating the performance of the intelligent model. We further improved the intelligent model's prediction accuracy by developing a two-phase feature selection algorithm to identify important attributes. Experimental results demonstrated that our approaches held the promise: they could effectively construct the intelligent model, evaluate its performance, and refine the participant model so that the intelligent model's prediction accuracy was significantly improved.

Dietary supplementation of coenzyme Q10 plus multivitamins to hamper the ROS mediated cisplatin ototoxicity in humans: A pilot study.

PubMed

Scasso, Felice; Sprio, Andrea Elio; Canobbio, Luciano; Scanarotti, Chiara; Manini, Giorgio; Berta, Giovanni Nicolao; Bassi, Anna Maria

2017-02-01

Oxidative stress exerts major role in the pathogenesis of side effects of many antineoplastic drugs, including ototoxicity of cisplatin. In particular, increased levels of reactive oxygen species (ROS) represent one of the molecular mechanisms underlying the apoptosis of different types of hearing cells. Antioxidants and ROS scavengers may thus represent potential therapeutic options to prevent platinum-associated ototoxicity. The aim of this preliminary case-control study was to explore the efficacy of a dietary antioxidant supplement, in order to hamper the occurrences of ototoxicity in patients undergoing cisplatin chemotherapy. As results, a significant protection against cochlear toxic damage was demonstrated in patients who took the antioxidant supplement, which furthermore prevented the occurrence of hearing disorders and tinnitus. These clinical evidences were corroborated by the oxidative status of patients. After cisplatin chemotherapy, the plasma derivatives of reactive oxygen metabolites (d-ROMs) content rapidly increased in control patients, but it was maintained in those under dietary supplementation, likely because of a higher anti-ROMs potential. Indeed, an increment in rapid anti-ROMs was detected in supplemented patients, though no differences were highlighted in terms of slow anti-ROMs. In conclusion, in this preliminary report we demonstrated the feasibility of a dietary antioxidant supplementation in order to prevent the cisplatin induced hearing damage.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Basher, A.M.H.

Poor control of steam generator water level of a nuclear power plant may lead to frequent nuclear reactor shutdowns. These shutdowns are more common at low power where the plant exhibits strong non-minimum phase characteristics and flow measurements at low power are unreliable in many instances. There is need to investigate this problem and systematically design a controller for water level regulation. This work is concerned with the study and the design of a suitable controller for a U-Tube Steam Generator (UTSG) of a Pressurized Water Reactor (PWR) which has time varying dynamics. The controller should be suitable for themore » water level control of UTSG without manual operation from start-up to full load transient condition. Some preliminary simulation results are presented that demonstrate the effectiveness of the proposed controller. The development of the complete control algorithm includes components such as robust output tracking, and adaptively estimating both the system parameters and state variables simultaneously. At the present time all these components are not completed due to time constraints. A robust tracking component of the controller for water level control is developed and its effectiveness on the parameter variations is demonstrated in this study. The results appear encouraging and they are only preliminary. Additional work is warranted to resolve other issues such as robust adaptive estimation.« less

A study for active control research and validation using the Total In-Flight Simulator (TIFS) aircraft

NASA Technical Reports Server (NTRS)

Chen, R. T. N.; Daughaday, H.; Andrisani, D., II; Till, R. D.; Weingarten, N. C.

1975-01-01

The results of a feasibility study and preliminary design for active control research and validation using the Total In-Flight Simulator (TIFS) aircraft are documented. Active control functions which can be demonstrated on the TIFS aircraft and the cost of preparing, equipping, and operating the TIFS aircraft for active control technology development are determined. It is shown that the TIFS aircraft is as a suitable test bed for inflight research and validation of many ACT concepts.

The feasibility study on 3-dimensional fluorescent x-ray computed tomography using the pinhole effect for biomedical applications.

PubMed

Sunaguchi, Naoki; Yuasa, Tetsuya; Hyodo, Kazuyuki; Zeniya, Tsutomu

2013-01-01

We propose a 3-dimensional fluorescent x-ray computed tomography (CT) pinhole collimator, aimed at providing molecular imaging with quantifiable measures and sub-millimeter spatial resolution. In this study, we demonstrate the feasibility of this concept and investigate imaging properties such as spatial resolution, contrast resolution and quantifiable measures, by imaging physical phantoms using a preliminary imaging system developed with monochromatic synchrotron x rays constructed at the BLNE-7A experimental line at KEK, Japan.

DEMONSTRATION OF A LIQUID CARBON DIOXIDE PROCESS FOR CLEANING METAL PARTS

EPA Science Inventory

The report gives results of a demonstration of liquid carbon dioxide (LCO2) as an alternative to chlorinated solvents for cleaning metal parts. It describes the LCO2 process, the parts tested, the contaminants removed, and results from preliminary laboratory testing and on-site d...

The Iodine Satellite (iSAT) Hall Thruster Demonstration Mission Concept and Development

NASA Technical Reports Server (NTRS)

Dankanich, John W.; Polzin, Kurt A.; Calvert, Derek; Kamhawi, Hani

2014-01-01

The use of iodine propellant for Hall thrusters has been studied and proposed by multiple organizations due to the potential mission benefits over xenon. In 2013, NASA Marshall Space Flight Center competitively selected a project for the maturation of an iodine flight operational feed system through the Technology Investment Program. Multiple partnerships and collaborations have allowed the team to expand the scope to include additional mission concept development and risk reduction to support a flight system demonstration, the iodine Satellite (iSAT). The iSAT project was initiated and is progressing towards a technology demonstration mission preliminary design review. The current status of the mission concept development and risk reduction efforts in support of this project is presented.

Overview of the MARS Laser Communications Demonstration Project

NASA Technical Reports Server (NTRS)

Edward, Bernard L.; Townes, Stephen A.; Bondurant, Roy S.; Scozzafava, Joseph J.; Boroson, Don M.; Parvin, Ben A.; Biswas, Abhijit; Pillsbury, Alan D.; Khatri, Farzana I.; Burnside, Jamie W.

2003-01-01

This paper provides an overview of the Mars Laser Communications Demonstration Project, a joint project between NASA s Goddard Space Flight Center (GSFC), the Jet Propulsion Laboratory, California Institute of Technology (JPL), and the Massachusetts Institute of Technology Lincoln Laboratory (MIT/LL). It reviews the strawman designs for the flight and ground segments, the critical technologies required, and the concept of operations. It reports preliminary conclusions from the Mars Lasercom Study conducted at MIT/LL and on additional work done at JPL and GSFC. The lasercom flight terminal will be flown on the Mars Telecom Orbiter (MTO) to be launched by NASA in 2009, and will demonstrate a technology which has the potential of vastly improving NASA s ability to communicate throughout the solar system.

Test set readings predict clinical performance to a limited extent: preliminary findings

NASA Astrophysics Data System (ADS)

Soh, BaoLin P.; Lee, Warwick M.; Kench, Peter L.; Reed, Warren M.; McEntee, Mark F.; Brennan, Patrick C.

2013-03-01

Aim: To investigate the level of agreement between test sets and actual clinical reading Background: The performance of screen readers in detecting breast cancer is being assessed in some countries by using mammographic test sets. However, previous studies have provided little evidence that performance assessed by test sets strongly correlate to performance in clinical reading. Methods: Five clinicians from BreastScreen New South Wales participated in this study. Each clinician was asked to read 200 de-identified mammographic examinations gathered from their own case history within the BreastScreen NSW Digital Imaging Library. All test sets were designed with specific proportions of true positive, true negative, false positive and false negative examinations from the previous actual clinical reads of each reader. A prior mammogram examination for comparison (when available) was also provided for each case. Results: Preliminary analyses have shown that there is a moderate level of agreement (Kappa 0.42-0.56, p < 0.001) between laboratory test sets and actual clinical reading. In addition, a mean increase of 38% in sensitivity in the laboratory test sets as compared to their actual clinical readings was demonstrated. Specificity is similar between the laboratory test sets and actual clinical reading. Conclusion: This study demonstrated a moderate level of agreement between actual clinical reading and test set reading, which suggests that test sets have a role in reflecting clinical performance.

Dating ancient mosaic glasses by luminescence: The case study of San Pietro in Vaticano

NASA Astrophysics Data System (ADS)

Galli, A.; Martini, M.; Sibilia, E.; Vandini, M.; Villa, I.

2011-12-01

The preliminary results of a study on the dosimetric properties of a set of glass tesserae from the mosaics of the vaults of St. Peter's Basilica in Rome (late XVI century) are reported. The main goal of the research was to assess the possibility of dating them by means of luminescence techniques. The samples had already been extensively studied and investigated from a historical, artistic and compositional point of view. The period of the making of the mosaic was rather well known, and could be the basis to test the experimental procedures we used for dosimetry. The experiments also aimed at demonstrating the validity of the hypothesis we put forward, i.e. the positive link between the presence of micro-crystals and the luminescence sensitivity in mosaic glass: to this aim, the samples richer in crystalline inclusions were selected. The role of calcium antimonate and cassiterite was definitely demonstrated. For what concerns their thermoluminescence (TL) characteristics, a preliminary investigation suggested that the available configuration of the detection systems did not properly fit the wavelength of the emitted TL. Much more promising results have been achieved by the use of Optically Stimulated Luminescence (OSL), even if the measured absorbed doses were rather scattered. For one sample with high OSL sensitivity, it was possible to establish its recent age, relative to one of the documented restorations that took place during the last century.

Spacecraft servicing demonstration plan

NASA Technical Reports Server (NTRS)

Bergonz, F. H.; Bulboaca, M. A.; Derocher, W. L., Jr.

1984-01-01

A preliminary spacecraft servicing demonstration plan is prepared which leads to a fully verified operational on-orbit servicing system based on the module exchange, refueling, and resupply technologies. The resulting system can be applied at the space station, in low Earth orbit with an orbital maneuvering vehicle (OMV), or be carried with an OMV to geosynchronous orbit by an orbital transfer vehicle. The three phase plan includes ground demonstrations, cargo bay demonstrations, and free flight verifications. The plan emphasizes the exchange of multimission modular spacecraft (MMS) modules which involves space repairable satellites. Three servicer mechanism configurations are the engineering test unit, a protoflight quality unit, and two fully operational units that have been qualified and documented for use in free flight verification activity. The plan balances costs and risks by overlapping study phases, utilizing existing equipment for ground demonstrations, maximizing use of existing MMS equipment, and rental of a spacecraft bus.

Regulation of pumping function of the heart in developing body under changing regimens of motor activity.

PubMed

Vafina, E Z; Abzalov, R A; Abzalov, N I; Nikitin, A S; Gulyakov, A A

2014-06-01

We analyzed parameters of the pumping function of the heart in rats subjected to enhanced motor activity after a preliminary 70-day hypokinesia under conditions of α- and β-adrenergic receptor stimulation with norepinephrine followed by blockade of β-adrenergic receptor with propranolol (obsidian) and α1-adrenergic receptors with doxazosin. After norepinephrine administration, the HR and cardiac output were higher in rats with enhanced physical activity after preliminary hypokinesia than in rats with low physical activity. After propranolol administration, stroke volume and cardiac output in 100-day-old rats with limited activity were lower, and HR higher was than in rats with enhanced physical activity after preliminary 70-day hypokinesia. After administration of doxazosin, rats with limited motor activity demonstrated more pronounced changes in HR than rats with enhanced physical activity after preliminary 70-day hypokinesia.

Preliminary Geologic/spectral Analysis of LANDSAT-4 Thematic Mapper Data, Wind River/bighorn Basin Area, Wyoming

NASA Technical Reports Server (NTRS)

Lang, H. R.; Conel, J. E.; Paylor, E. D.

1984-01-01

A LIDQA evaluation for geologic applications of a LANDSAT TM scene covering the Wind River/Bighorn Basin area, Wyoming, is examined. This involves a quantitative assessment of data quality including spatial and spectral characteristics. Analysis is concentrated on the 6 visible, near infrared, and short wavelength infrared bands. Preliminary analysis demonstrates that: (1) principal component images derived from the correlation matrix provide the most useful geologic information. To extract surface spectral reflectance, the TM radiance data must be calibrated. Scatterplots demonstrate that TM data can be calibrated and sensor response is essentially linear. Low instrumental offset and gain settings result in spectral data that do not utilize the full dynamic range of the TM system.

Intelligent redundant actuation system requirements and preliminary system design

NASA Technical Reports Server (NTRS)

Defeo, P.; Geiger, L. J.; Harris, J.

1985-01-01

Several redundant actuation system configurations were designed and demonstrated to satisfy the stringent operational requirements of advanced flight control systems. However, this has been accomplished largely through brute force hardware redundancy, resulting in significantly increased computational requirements on the flight control computers which perform the failure analysis and reconfiguration management. Modern technology now provides powerful, low-cost microprocessors which are effective in performing failure isolation and configuration management at the local actuator level. One such concept, called an Intelligent Redundant Actuation System (IRAS), significantly reduces the flight control computer requirements and performs the local tasks more comprehensively than previously feasible. The requirements and preliminary design of an experimental laboratory system capable of demonstrating the concept and sufficiently flexible to explore a variety of configurations are discussed.

eVITAL: A Preliminary Taxonomy and Electronic Toolkit of Health-Related Habits and Lifestyle

PubMed Central

Salvador-Carulla, Luis; Olson Walsh, Carolyn; Alonso, Federico; Gómez, Rafael; de Teresa, Carlos; Cabo-Soler, José Ricardo; Cano, Antonio; Ruiz, Mencía

2012-01-01

Objectives. To create a preliminary taxonomy and related toolkit of health-related habits (HrH) following a person-centered approach with a focus on primary care. Methods. From 2003–2009, a working group (n = 6 physicians) defined the knowledge base, created a framing document, and selected evaluation tools using an iterative process. Multidisciplinary focus groups (n = 29 health professionals) revised the document and evaluation protocol and participated in a feasibility study and review of the model based on a demonstration study with 11 adult volunteers in Antequera, Spain. Results. The preliminary taxonomy contains 6 domains of HrH and 1 domain of additional health descriptors, 3 subdomains, 43 dimensions, and 141 subdimensions. The evaluation tool was completed by the 11 volunteers. The eVITAL toolkit contains history and examination items for 4 levels of engagement: self-assessment, basic primary care, extended primary care, and specialty care. There was positive feedback from the volunteers and experts, but concern about the length of the evaluation. Conclusions. We present the first taxonomy of HrH, which may aid the development of the new models of care such as the personal contextual factors of the International Classification of Functioning (ICF) and the positive and negative components of the multilevel person-centered integrative diagnosis model. PMID:22545016

Antidepressant response to aripiprazole augmentation associated with enhanced FDOPA utilization in striatum: a preliminary PET study

PubMed Central

Conway, Charles R.; Chibnall, John T.; Cumming, Paul; Mintun, Mark A.; Gebara, Marie Anne I.; Perantie, Dana C.; Price, Joseph L.; Cornell, Martha E.; McConathy, Jonathan E.; Gangwani, Sunil; Sheline, Yvette I.

2014-01-01

Several double blind, prospective trials have demonstrated an antidepressant augmentation efficacy of aripiprazole in depressed patients unresponsive to standard antidepressant therapy. Although aripiprazole is now widely used for this indication, and much is known about its receptor-binding properties, the mechanism of its antidepressant augmentation remains ill-defined. In vivo animal studies and in vitro human studies using cloned dopamine dopamine D2 receptors suggest aripiprazole is a partial dopamine agonist; in this preliminary neuroimaging trial, we hypothesized that aripiprazole’s antidepressant augmentation efficacy arises from dopamine partial agonist activity. To test this, we assessed the effects of aripiprazole augmentation on the cerebral utilization of 6-[18F]-fluoro-3,4-dihydroxy-L-phenylalanine (FDOPA) using positron emission tomography (PET). Fourteen depressed patients, who had failed 8 weeks of antidepressant therapy with selective serotonin reuptake inhibitors, underwent FDOPA PET scans before and after aripiprazole augmentation; eleven responded to augmentation. Whole brain, voxel-wise comparisons of pre- and post-aripiprazole scans revealed increased FDOPA trapping in the right medial caudate of augmentation responders. An exploratory analysis of depressive symptoms revealed that responders experienced large improvements only in putatively dopaminergic symptoms of lassitude and inability to feel. These preliminary findings suggest that augmentation of antidepressant response by aripiprazole may be associated with potentiation of dopaminergic activity. PMID:24468015

A field study of wind over a simulated block building

NASA Technical Reports Server (NTRS)

Frost, W.; Shahabi, A. M.

1977-01-01

A full-scale field study of the wind over a simulated two-dimensional building is reported. The study develops an experiment to investigate the structure and magnitude of the wind fields. A description of the experimental arrangement, the type and expected accuracy of the data, and the range of the data are given. The data are expected to provide a fundamental understanding of mean wind and turbulence structure of the wind field around the bluff body. Preliminary analysis of the data demonstrates the reliability and completeness of the data in this regard.

Toward Scalable Ion Traps for Quantum Information Processing

DTIC Science & Technology

2010-01-01

3/033031 Abstract. In this paper, we report the design, fabrication and preliminary testing of a 150 zone ion trap array built in a ‘ surface ...gates [4–6]. We report here on the design, fabrication and preliminary testing of a large array built in a ‘ surface -electrode’ geometry [7, 8] and...report the first transport of atomic ions through a surface -electrode trap junction. Transport of ions through a junction has been demonstrated previously

Affordable Development and Demonstration of a Small NTR engine and Stage: A Preliminary NASA, DOE, and Industry Assessment

NASA Technical Reports Server (NTRS)

Borowski, S. K.; Sefcik, R. J.; Fittje, J. E.; McCurdy, D. R.; Qualls, A. L.; Schnitzler, B. G; Werner, J.; Weitzberg, A.; Joyner, C. R.

2015-01-01

In FY'11, Nuclear Thermal Propulsion (NTP) was identified as a key propulsion option under the Advanced In-Space Propulsion (AISP) component of NASA's Exploration Technology Development and Demonstration (ETDD) program A strategy was outlined by GRC and NASA HQ that included 2 key elements -"Foundational Technology Development" followed by specific "Technology Demonstration" projects. The "Technology Demonstration "element proposed ground technology demonstration (GTD) testing in the early 2020's, followed by a flight technology demonstration (FTD) mission by approx. 2025. In order to reduce development costs, the demonstration projects would focus on developing a small, low thrust (approx. 7.5 -16.5 klb(f)) engine that utilizes a "common" fuel element design scalable to the higher thrust (approx. 25 klb(f)) engines used in NASA's Mars DRA 5.0 study(NASA-SP-2009-566). Besides reducing development costs and allowing utilization of existing, flight proven engine hard-ware (e.g., hydrogen pumps and nozzles), small, lower thrust ground and flight demonstration engines can validate the technology and offer improved capability -increased payloads and decreased transit times -valued for robotic science missions identified in NASA's Decadal Study.

Imaging and sensing based on dual-pulse nonlinear photoacoustic contrast: a preliminary study on fatty liver

NASA Astrophysics Data System (ADS)

Tian, Chao; Xie, Zhixing; Fabiilli, Mario; Wang, Xueding

2015-03-01

We developed a simple and effective contrast for tissue characterization based on the recently proposed dual-pulse nonlinear photoacoustic technology. The new contrast takes advantage of the temperature dependence of Grüneisen parameter of tissue and involves a dual-pulse laser excitation process. A short pulse first heats the sample and causes a temperature jump, which then leads to the change of Grüneisen parameter and amplitude of the photoacoustic signal of the second pulse. For different tissues, the induced rate or trend of change is expected to be different, which constitutes the basis of the new contrast. Preliminary phantom experiment in blood and lipid mixtures and in vitro experiment in fatty rat liver have demonstrated that the proposed contrast has the capability of fast characterization of lipid-rich and blood-rich tissues.

Status review of NASA programs for reducing aircraft gas turbine engine emissions

NASA Technical Reports Server (NTRS)

Rudey, R. A.

1976-01-01

Programs initiated by NASA to develop and demonstrate low emission advanced technology combustors for reducing aircraft gas turbine engine pollution are reviewed. Program goals are consistent with urban emission level requirements as specified by the U. S. Environmental Protection Agency and with upper atmosphere cruise emission levels as recommended by the U. S. Climatic Impact Assessment Program and National Research Council. Preliminary tests of advanced technology combustors indicate that significant reductions in all major pollutant emissions should be attainable in present generation aircraft gas turbine engines without adverse effects on fuel consumption. Preliminary test results from fundamental studies indicate that extremely low emission combustion systems may be possible for future generation jet aircraft. The emission reduction techniques currently being evaluated in these programs are described along with the results and a qualitative assessment of development difficulty.

A preliminary examination of the validity and reliability of a new brief rating scale for symptom domains of psychosis: Brief Evaluation of Psychosis Symptom Domains (BE-PSD).

PubMed

Takeuchi, Hiroyoshi; Fervaha, Gagan; Lee, Jimmy; Agid, Ofer; Remington, Gary

2016-09-01

Brief assessments have the potential to be widely adopted as outcome measures in research but also routine clinical practice. Existing brief rating scales that assess symptoms of schizophrenia or psychosis have a number of limitations including inability to capture five symptom domains of psychosis and a lack of clearly defined operational anchor points for scoring. We developed a new brief rating scale for five symptom domains of psychosis with clearly defined operational anchor points - the Brief Evaluation of Psychosis Symptom Domains (BE-PSD). To examine the psychometric properties of the BE-PSD, fifty patients with schizophrenia or schizoaffective disorder were included in this preliminary cross-sectional study. To test the convergent and discriminant validity of the BE-PSD, correlational analyses were employed using the consensus Positive and Negative Syndrome Scale (PANSS) five-factor model. To examine the inter-rater reliability of the BE-PSD, single measures intraclass correlation coefficients (ICCs) were calculated for 11 patients. The BE-PSD domain scores demonstrated high convergent validity with the corresponding PANSS factor score (rs = 0.81-0.93) as well as good discriminant validity, as evidenced by lower correlations with the other PANSS factors (rs = 0.23-0.62). The BE-PSD also demonstrated excellent inter-rater reliability for each of the domain scores and the total scores (ICC(2,1) = 0.79-0.96). The present preliminary study found the BE-PSD measure to be valid and reliable; however, further studies are needed to establish the psychometric properties of the BE-PSD because of the limitations such as the small sample size and lacking data on test-retest reliability or sensitivity to change. Copyright © 2016 Elsevier Ltd. All rights reserved.

Cognitive Task Analysis of Business Jet Pilots' Weather Flying Behaviors: Preliminary Results

NASA Technical Reports Server (NTRS)

Latorella, Kara; Pliske, Rebecca; Hutton, Robert; Chrenka, Jason

2001-01-01

This report presents preliminary findings from a cognitive task analysis (CTA) of business aviation piloting. Results describe challenging weather-related aviation decisions and the information and cues used to support these decisions. Further, these results demonstrate the role of expertise in business aviation decision-making in weather flying, and how weather information is acquired and assessed for reliability. The challenging weather scenarios and novice errors identified in the results provide the basis for experimental scenarios and dependent measures to be used in future flight simulation evaluations of candidate aviation weather information systems. Finally, we analyzed these preliminary results to recommend design and training interventions to improve business aviation decision-making with weather information. The primary objective of this report is to present these preliminary findings and to document the extended CTA methodology used to elicit and represent expert business aviator decision-making with weather information. These preliminary findings will be augmented with results from additional subjects using this methodology. A summary of the complete results, absent the detailed treatment of methodology provided in this report, will be documented in a separate publication.

Preliminary plan for a Shuttle Coherent Atmospheric Lidar Experiment (SCALE)

NASA Technical Reports Server (NTRS)

Fitzjarrald, D.; Beranek, R.; Bilbro, J.; Mabry, J.

1985-01-01

A study has been completed to define a Shuttle experiment that solves the most crucial scientific and engineering problems involved in building a satellite Doppler wind profiler for making global wind measurements. The study includes: (1) a laser study to determine the feasibility of using the existing NOAA Windvan laser in the Space Shuttle spacecraft; (2) a preliminary optics and telescope design; (3) an accommodations study including power, weight, thermal, and control system requirements; and (4) a flight trajectory and operations plan designed to accomplish the required scientific and engineering goals. The experiment will provide much-needed data on the global distribution of atmospheric aerosols and demonstrate the technique of making wind measurements from space, including scanning the laser beam and interpreting the data. Engineering accomplishments will include space qualification of the laser, development of signal processing and lag angle compensation hardware and software, and telescope and optics design. All of the results of this limited Spacelab experiment will be directly applicable to a complete satellite wind profiler for the Earth Observation System/Space Station or other free-flying satellite.

Preliminary Assessment of Thrust Augmentation of NEP Based Missions

NASA Technical Reports Server (NTRS)

Chew, Gilbert; Pelaccio, Dennis G.; Chiroux, Robert; Pervan, Sherry; Rauwolf, Gerald A.; White, Charles

2005-01-01

Science Applications International Corporation (SAIC), with support from NASA Marshall Space Flight Center, has conducted a preliminary study to compare options for augmenting the thrust of a conventional nuclear electric propulsion (NEP) system. These options include a novel nuclear propulsion system concept known as Hybrid Indirect Nuclear Propulsion (HINP) and conventional chemical propulsion. The utility and technical feasibility of the HINP concept are assessed, and features and potential of this new in-space propulsion system concept are identified. As part of the study, SAIC developed top-level design tools to model the size and performance of an HINP system, as well as for several chemical propulsion options, including liquid and gelled propellants. A mission trade study was performed to compare a representative HINP system with chemical propulsion options for thrust augmentation of NEP systems for a mission to Saturn's moon Titan. Details pertaining to the approach, features, initial demonstration results for HINP model development, and the mission trade study are presented. Key technology and design issues associated with the HINP concept and future work recommendations are also identified.

Development of a Surface Plasmon Resonance n-dodecane Vapor Sensor

PubMed Central

Aguirre, Narcizo Muñoz; Pérez, Lilia Martínez; Colín, Jose Alfredo; Buenrostro-Gonzalez, Eduardo

2007-01-01

Using a high density polyethylene thin film over gold layer, a Surface Plasmon Resonance sensor for detecting n-dodecane vapor is developed. Preliminary results will be presented, showing that samples in the range of a few hundred ppm(V) of n-dodecane vapor in butane gas can be sensed. Also, studying the response as a function of time, it is demonstrated that the sensing process is quickly reversible. PMID:28903207

High-power free-electron maser with frequency multiplication operating in a shortwave part of the millimeter wave range

NASA Astrophysics Data System (ADS)

Bandurkin, I. V.; Kaminsky, A. K.; Perelstein, E. A.; Peskov, N. Yu.; Savilov, A. V.; Sedykh, S. N.

2012-08-01

The possibility of using frequency multiplication in order to obtain high-power short-wavelength radiation from a free-electron maser (FEM) with a Bragg resonator has been studied. Preliminary experiments with an LIU-3000 (JINR) linear induction accelerator demonstrate the operation of a frequency-multiplying FEM at megawatt power in the 6- and 4-mm wave bands on the second and third harmonic, respectively.

Alpha Particle Induced X-ray Emission in the Classroom

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lopez, Jorge A.; Borunda, Mario F.; Morales, Jaime

2003-08-26

We report on an experimental demonstration in an introductory modern physics course to elucidate the X-ray line spectra, and how they arise from transitions of electrons to inner shells. We seek to determine the effect of limited use of an interactive component as a supplement to a traditional lecture, and how it would improve the student achievement. In this preliminary study the students were exposed to traditional lectures on X-ray production and Bohr's model, they then were given a homework on the abc of X-ray spectra, after which they were given a pre-test on the materials, followed by an in-classmore » demonstration, and a final post-exam. The gain, as measured from pre- to post-exams appears to remark the differences in how students approached the subject before and after the use of the demonstration. This initial study shows the validity of in-class demonstrations as teaching tools and opens a wide new area of research in modern physics teaching.« less

Functionalized Nanopipettes: A Sensitive Tool for Pathogen Detection

NASA Astrophysics Data System (ADS)

Actis, P.; Jejelowo, O.; Pourmand, N.

2010-04-01

Nanopipette technology is capable of detecting and functional analyzing biomolecules. Preliminary experiments are demonstrating the sensitivity and selectivity of the technique with specific proteins targeting environmental toxins.

Sulfate reducing bacteria in microbial mats: Changing paradigms, new discoveries

NASA Astrophysics Data System (ADS)

Baumgartner, L. K.; Reid, R. P.; Dupraz, C.; Decho, A. W.; Buckley, D. H.; Spear, J. R.; Przekop, K. M.; Visscher, P. T.

2006-03-01

Sulfate reducing bacteria (SRB) have existed throughout much of Earth's history and remain major contributors to carbon cycling in modern systems. Despite their importance, misconceptions about SRB are prevalent. In particular, SRB are commonly thought to lack oxygen tolerance and to exist only in anoxic environments. Through the last two decades, researchers have discovered that SRB can, in fact, tolerate and even respire oxygen. Investigations of microbial mat systems have demonstrated that SRB are both abundant and active in the oxic zones of mats. Additionally, SRB have been found to be highly active in the lithified zones of microbial mats, suggesting a connection between sulfate reduction and mat lithification. In the present paper, we review recent research on SRB distribution and present new preliminary findings on both the diversity and distribution of δ-proteobacterial SRB in lithifying and non-lithifying microbial mat systems. These preliminary findings indicate the unexplored diversity of SRB in a microbial mat system and demonstrate the close microspatial association of SRB and cyanobacteria in the oxic zone of the mat. Possible mechanisms and further studies to elucidate mechanisms for carbonate precipitation via sulfate reduction are also discussed.

Analytical and Radio-Histo-Chemical Experiments of Plants and Tissue Culture Cells Treated with Lunar and Terrestrial Materials

NASA Technical Reports Server (NTRS)

Halliwell, R. S.

1973-01-01

The nature and mechanisms of the apparent simulation of growth originally observed in plants growing in contact with lunar soil during the Apollo project quarantine are examined. Preliminary experiments employing neutron activated lunar soil indicate uptake of a few elements by plants. It was found that while the preliminary neutron activation technique allowed demonstration of uptake of minerals it presented numerous disadvantages for use in critical experiments directed at elucidating possible mechanisms of stimulation.

Automated iodine monitor system. [for aqueous solutions

NASA Technical Reports Server (NTRS)

1973-01-01

The feasibility of a direct spectrophotometric measurement of iodine in water was established. An iodine colorimeter, was built to demonstrate the practicality of this technique. The specificity of this method was verified when applied to an on-line system where a reference solution cannot be used, and a preliminary design is presented for an automated iodine measuring and controlling system meeting the desired specifications. An Automated iodine monitor/controller system based on this preliminary design was built, tested, and delivered to the Johnson Space Center.

The Tiptop coal-mine fire, Kentucky: Preliminary investigation of the measurement of mercury and other hazardous gases from coal-fire gas vents

USGS Publications Warehouse

Hower, James C.; Henke, Kevin R.; O'Keefe, Jennifer M.K.; Engle, Mark A.; Blake, Donald R.; Stracher, Glenn B.

2009-01-01

Variation in gas temperatures, nearly 300 °C during the January visit to the fire versus < 50 °C in May, demonstrates the large temporal variability in fire intensity at the Tiptop mine. These preliminary results suggest that emissions from coal fires may be important, but additional data are required that address the reasons for significant variations in the composition, flow, and temperature of vent gases.

Ambient Assisted Living and ageing: preliminary results of RITA project.

PubMed

Aquilano, Michela; Cavallo, Filippo; Bonaccorsi, Manuele; Esposito, Raffaele; Rovini, Erika; Filippi, Massimo; Esposito, Dario; Dario, Paolo; Carrozza, Maria Chiara

2012-01-01

The ageing of population is a social phenomenon that most of worldwide countries are facing. They are, and will be even more in the future, indeed trying to find solutions for improving quality of life of their elderly citizens. The project RITA wants to demonstrate that an update of the current socio-medical services with an Ambient Assisted Living (AAL) approach could improve the service efficiency and the quality of life of both elderly and caregiver. This paper presents the preliminary results obtained in RITA.

Preliminary disposal limits, plume interaction factors, and final disposal limits

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flach, G.

In the 2008 E-Area Performance Assessment (PA), each final disposal limit was constructed as the product of a preliminary disposal limit and a plume interaction factor. The following mathematical development demonstrates that performance objectives are generally expected to be satisfied with high confidence under practical PA scenarios using this method. However, radionuclides that experience significant decay between a disposal unit and the 100-meter boundary, such as H-3 and Sr-90, can challenge performance objectives, depending on the disposed-of waste composition, facility geometry, and the significance of the plume interaction factor. Pros and cons of analyzing single disposal units or multiple disposalmore » units as a group in the preliminary disposal limits analysis are also identified.« less

Preliminary Results of the Ground/Orbiter Lasercomm Demonstration Experiment between Table Mountain and teh ETS-V1 Satellite

NASA Technical Reports Server (NTRS)

Wilson, K. E.; Lesh, J. R.; Araki, K.; Arimoto, Y.

1996-01-01

The Ground/Orbiter Lasercomm Demonstration (GOLD) is an optical communications demonstration between the Japanese Engineering Test Satellite (ETS-V1) and an optical ground transmitting and receiving station at the Table Mountain FAcility in Wrightwood California. Laser transmissions to the satellite are performed approximately four hours every third night when the satellite is at apogee above Table Mountain.

Android Robot-Mediated Mock Job Interview Sessions for Young Adults with Autism Spectrum Disorder: A Pilot Study

PubMed Central

Kumazaki, Hirokazu; Warren, Zachary; Corbett, Blythe A.; Yoshikawa, Yuichiro; Matsumoto, Yoshio; Higashida, Haruhiro; Yuhi, Teruko; Ikeda, Takashi; Ishiguro, Hiroshi; Kikuchi, Mitsuru

2017-01-01

The feasibility and preliminary efficacy of an android robot-mediated mock job interview training in terms of both bolstering self-confidence and reducing biological levels of stress in comparison to a psycho-educational approach human interview was assessed in a randomized study. Young adults (ages 18–25 years) with autism spectrum disorder (ASD) were randomized to participate either in a mock job interview training with our android robot system (n = 7) or a self-paced review of materials about job-interviewing skills (n = 8). Baseline and outcome measurements of self-reported performance/efficacy and salivary cortisol were obtained after a mock job interview with a human interviewer. After training sessions, individuals with ASD participating in the android robot-mediated sessions reported marginally improved self-confidence and demonstrated significantly lower levels of salivary cortisol as compared to the control condition. These results provide preliminary support for the feasibility and efficacy of android robot-mediated learning. PMID:28955254

Android Robot-Mediated Mock Job Interview Sessions for Young Adults with Autism Spectrum Disorder: A Pilot Study.

PubMed

Kumazaki, Hirokazu; Warren, Zachary; Corbett, Blythe A; Yoshikawa, Yuichiro; Matsumoto, Yoshio; Higashida, Haruhiro; Yuhi, Teruko; Ikeda, Takashi; Ishiguro, Hiroshi; Kikuchi, Mitsuru

2017-01-01

The feasibility and preliminary efficacy of an android robot-mediated mock job interview training in terms of both bolstering self-confidence and reducing biological levels of stress in comparison to a psycho-educational approach human interview was assessed in a randomized study. Young adults (ages 18-25 years) with autism spectrum disorder (ASD) were randomized to participate either in a mock job interview training with our android robot system ( n  = 7) or a self-paced review of materials about job-interviewing skills ( n  = 8). Baseline and outcome measurements of self-reported performance/efficacy and salivary cortisol were obtained after a mock job interview with a human interviewer. After training sessions, individuals with ASD participating in the android robot-mediated sessions reported marginally improved self-confidence and demonstrated significantly lower levels of salivary cortisol as compared to the control condition. These results provide preliminary support for the feasibility and efficacy of android robot-mediated learning.

A Preliminary Study of the Effectiveness of Different Recitation Teaching Methods

NASA Astrophysics Data System (ADS)

Endorf, Robert J.; Koenig, Kathleen M.; Braun, Gregory A.

2006-02-01

We present preliminary results from a comparative study of student understanding for students who attended recitation classes which used different teaching methods. Student volunteers from our introductory calculus-based physics course attended a special recitation class that was taught using one of four different teaching methods. A total of 272 students were divided into approximately equal groups for each method. Students in each class were taught the same topic, "Changes in energy and momentum," from Tutorials in Introductory Physics. The different teaching methods varied in the amount of student and teacher engagement. Student understanding was evaluated through pretests and posttests given at the recitation class. Our results demonstrate the importance of the instructor's role in teaching recitation classes. The most effective teaching method was for students working in cooperative learning groups with the instructors questioning the groups using Socratic dialogue. These results provide guidance and evidence for the teaching methods which should be emphasized in training future teachers and faculty members.

Synthesis of [{sup 125}I]iodoDPA-713: A new probe for imaging inflammation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Haofan; Pullambhatla, Mrudula; Guilarte, Tomas R.

2009-11-06

[{sup 125}I]IodoDPA-713 [{sup 125}I]1, which targets the translocator protein (TSPO, 18 kDa), was synthesized in seven steps from methyl-4-methoxybenzoate as a tool for quantification of inflammation in preclinical models. Preliminary in vitro autoradiography and in vivo small animal imaging were performed using [{sup 125}I]1 in a neurotoxicant-treated rat and in a murine model of lung inflammation, respectively. The radiochemical yield of [{sup 125}I]1 was 44 {+-} 6% with a specific radioactivity of 51.8 GBq/{mu}mol (1400 mCi/{mu}mol) and >99% radiochemical purity. Preliminary studies showed that [{sup 125}I]1 demonstrated increased specific binding to TSPO in a neurotoxicant-treated rat and increased radiopharmaceutical uptakemore » in the lungs of an experimental inflammation model of lung inflammation. Compound [{sup 125}I]1 is a new, convenient probe for preclinical studies of TSPO activity.« less

Application of membrane bioreactors in the preliminary treatment of early planetary base wastewater for long-duration space missions.

PubMed

Zhang, Kai; Choi, Hyeok; Dionysiou, Dionysios D; Oerther, Daniel B

2008-12-01

Membrane bioreactors (MBRs) are the preferred technology for the preliminary treatment of Early Planetary Base Wastewater (EPBW) because of their compact configuration and promising treatment performance. For long-duration space missions, irreversible membrane biofouling resulting from the strong attachment of biomass and the formation of biofilms are major concerns for the MBR process. In this study, a MBR was operated for 230 days treating synthetic EPBW. The reactor demonstrated excellent treatment performance, in terms of chemical oxygen demand removal and nitrification. Filtration resistance is mainly caused by concentration polarization, reversible fouling, and irreversible fouling. Analysis of the microbial communities in the planktonic and corresponding sessile biomass suggested that the microbial community of the planktonic biomass was significantly different from the one of the sessile biomass. This study provides valuable information for the development of the water reuse component in the National Aeronautics and Space Administration's (Washington, D.C.) Advanced Life Support system for long-term space missions.

A Pilot Study of a Peer-Group Lifestyle Intervention Enhanced With mHealth Technology and Social Media for Adults With Serious Mental Illness.

PubMed

Aschbrenner, Kelly A; Naslund, John A; Shevenell, Megan; Kinney, Elizabeth; Bartels, Stephen J

2016-06-01

This pilot study examined the preliminary effectiveness of a peer-group lifestyle intervention enhanced with mobile health technology and social media for obese individuals with serious mental illness. Thirty-two participants with a body mass index of 30 or higher received a 24-week intervention designed to facilitate peer support for lifestyle change through experiential learning and use of wearable activity tracking devices, smartphone applications, and Facebook to reinforce physical activity, healthy eating, and group participation between sessions. The primary outcome was weight loss. Secondary measures included fitness and participants' perceptions of peer-group support. Most participants (72%) lost weight, including 28% achieving clinically significant weight loss, and 17% of participants showed clinically significant improvements in cardiovascular fitness. Weight loss was associated with perceived peer-group support. This evaluation demonstrated the preliminary effectiveness of a potentially scalable peer-group lifestyle intervention delivered in community mental health settings for obese individuals with serious mental illness.

Preliminary study of high energy density Zn/Ni flow batteries

NASA Astrophysics Data System (ADS)

Liu, Jin; Wang, Yan

2015-10-01

The escalation of power system promotes the development of energy storage technologies (ESTs). Among all of ESTs, battery technologies develop quickly and diversely because of its huge application market. Aqueous redox flow batteries (RFBs) are very attractive to customers in the energy grid system, and their noticeable technological innovations in past decades are driving them to gradually replace the conventional ESTs under certain circumstance. Here, the first fully-flow-able zinc-nickel flow battery (ZNFB) is preliminary reported in this paper, and its superior performance is supposed to be suitable for both large-scale storage need and carry-on powertrain in cars. Through using semi-solid fuel cell (SSFC) technology, we incorporates the beneficial features of Zn/Ni chemistry (essentially sustainable, eco-friendly and deposit-abundant) into RFB structure to make a ;hybrid; flow battery system, which can take the advantage of both. The relationship between carbon loading and suspension conductivity is determined. Electrochemical properties of ZNFB as static test, cycling test, and fully flowing test are studied to demonstrate our design.

Financial Decision-making Abilities and Financial Exploitation in Older African Americans: Preliminary Validity Evidence for the Lichtenberg Financial Decision Rating Scale (LFDRS)

PubMed Central

Ficker, Lisa J.; Rahman-Filipiak, Annalise

2015-01-01

This study examines preliminary evidence for the Lichtenberg Financial Decision Rating Scale (LFDRS), a new person-centered approach to assessing capacity to make financial decisions, and its relationship to self-reported cases of financial exploitation in 69 older African Americans. More than one third of individuals reporting financial exploitation also had questionable decisional abilities. Overall, decisional ability score and current decision total were significantly associated with cognitive screening test and financial ability scores, demonstrating good criterion validity. Financially exploited individuals, and non-exploited individuals, showed mean group differences on the Mini Mental State Exam, Financial Situational Awareness, Psychological Vulnerability, Current Decisional Ability, and Susceptibility to undue influence subscales, and Total Lichtenberg Financial Decision Rating Scale Score. Study findings suggest that impaired decisional abilities may render older adults more vulnerable to financial exploitation, and that the LFDRS is a valid tool for measuring both decisional abilities and financial exploitation. PMID:26285038

The clinical evaluation of Pterocarpus santalinus Linn. Ointment on lower extremity wounds--a preliminary report.

PubMed

Biswas, Tuhin Kanti; Maity, Lakshmi Narayan; Mukherjee, Biswapati

2004-12-01

Pterocarpus santalinus is described in the Ayurveda for its wide spectrum of medicinal properties including wound healing. Previously the authors reported animal studies that demonstrated that an ointment made from the bark of this tree was effective without any toxic effects. They used the same ointment in 6 cases of lower extremity wounds. Healing was observed in all wounds. The study was not controlled, the findings are presented here as case studies. Further studies are planned to develop a wound healing ointment from a locally available and inexpensive plant.

Exoskeletal Engine Concept: Feasibility Studies for Medium and Small Thrust Engines

NASA Technical Reports Server (NTRS)

Halliwell, Ian

2001-01-01

The exoskeletal engine concept is one in which the shafts and disks are eliminated and are replaced by rotating casings that support the blades in spanwise compression. Omission of the shafts and disks leads to an open channel at the engine centerline. This has immense potential for reduced jet noise and for the accomodation of an alternative form of thruster for use in a combined cycle. The use of ceramic composite materials has the potential for significantly reduced weight as well as higher working temperatures without cooling air. The exoskeletal configuration is also a natural stepping-stone to complete counter-rotating turbomachinery. Ultimately this will lead to reductions in weight, length, parts count and improved efficiency. The feasibility studies are in three parts. Part I-Systems and Component Requirements addressed the mechanical aspects of components from a functionality perspective. This effort laid the groundwork for preliminary design studies. Although important, it is not felt to be particularly original, and has therefore not been included in the current overview. Part 2-Preliminary Design Studies turned to some of the cycle and performance issues inherent in an exoskeletal configuration and some initial attempts at preliminary design of turbomachinery were described. Twin-spoon and single-spool 25.800-lbf-thrust turbofans were used as reference vehicles in a mid-size commercial subsonic category in addition to a single-spool 5,000-lbf-thrust turbofan that represented a general aviation application. The exoskeletal engine, with its open centerline, has tremendous potential for noise suppression and some preliminary analysis was done which began to quantify the benefits. Part 3-Additional Preliminary Design Studies revisited the design of single-spool 25,800-lbf-thrust turbofan configurations, but in addition to the original FPR = 1.6 and BPR = 5.1 reference engine, two additional configurations used FPR = 2.4 and BPR = 3.0 and FPR = 3.2 and BPR = 2.0 were investigated. The single-spool 5,000-lbf-thrust turbofan was refined and the small engine study was extended to include a 2,000-lbf-thrust turbojet. More attention was paid to optimizing the turbomachinery. Turbine cooling flows were eliminated, in keeping with the use of uncooled CMC material in exoskeletal engines. The turbine performance parameters moved much closer to the nominal target values, demonstrating the great benefits to the cycle of uncooled turbines.

Exoskeletal Engine Concept: Feasibility Studies for Medium and Small Thrust Engines

NASA Technical Reports Server (NTRS)

Halliwell, Ian

2001-01-01

The exoskeletal engine concept is one in which the shafts and disks are eliminated and are replaced by rotating casings that support the blades in spanwise compression. Omission of the shafts and disks leads to an open channel at the engine centerline. This has immense potential for reduced jet noise and for the accommodation of an alternative form of thruster for use in a combined cycle. The use of ceramic composite materials has the potential for significantly reduced weight as well as higher working temperatures without cooling air. The exoskeletal configuration is also a natural stepping-stone to complete counter-rotating turbomachinery. Ultimately this will lead to reductions in weight, length, parts count and improved efficiency. The feasibility studies are in three parts. Part 1: Systems and Component Requirements addressed the mechanical aspects of components from a functionality perspective. This effort laid the groundwork for preliminary design studies. Although important, it is not felt to be particularly original, and has therefore not been included in the current overview. Part 2: Preliminary Design Studies turned to some of the cycle and performance issues inherent in an exoskeletal configuration and some initial attempts at preliminary design of turbomachinery were described. Twin-spoon and single-spool 25,800-lbf-thrust turbofans were used as reference vehicles in a mid-size commercial subsonic category in addition to a single-spool 5,000-lbf-thrust turbofan that represented a general aviation application. The exoskeletal engine, with its open centerline, has tremendous potential for noise suppression and some preliminary analysis was done which began to quantify the benefits. Part 3: Additional Preliminary Design Studies revisited the design of single-spool 25,800-lbf-thrust turbofan configurations, but in addition to the original FPR = 1.6 and BPR = 5.1 reference engine. two additional configurations used FPR = 2.4 and BPR = 3.0 and FPR = 3.2 and BPR = 2.0 were investigated. The single-spool 5.000-lbf-thrust turbofan was refined and the small engine study was extended to include a 2,000-lbf-thrust turbojet. More attention was paid to optimizing the turbomachinery. Turbine cooling flows were eliminated, in keeping with the use of uncooled CMC materials in exoskeletal engines. The turbine performance parameters moved much closer to the nominal target values, demonstrating the great benefits to the cycle of uncooled turbines.

Antifungal activity of synthetic naphthoquinones against dermatophytes and opportunistic fungi: preliminary mechanism-of-action tests.

PubMed

Ferreira, Maria do Perpetuo Socorro Borges Carriço; Cardoso, Mariana Filomena do Carmo; da Silva, Fernando de Carvalho; Ferreira, Vitor Francisco; Lima, Emerson Silva; Souza, João Vicente Braga

2014-07-06

This study evaluated the antifungal activities of synthetic naphthoquinones against opportunistic and dermatophytic fungi and their preliminary mechanisms of action. The minimum inhibitory concentrations (MICs) of four synthetic naphthoquinones for 89 microorganisms, including opportunistic yeast agents, dermatophytes and opportunistic filamentous fungi, were determined. The compound that exhibited the best activity was assessed for its action against the cell wall (sorbitol test), for interference associated with ergosterol interaction, for osmotic balance (K+ efflux) and for membrane leakage of substances that absorb at the wavelength of 260 nm. All tested naphthoquinones exhibited antifungal activity, and compound IVS320 (3a,10b-dihydro-1H-cyclopenta [b] naphtho [2,3-d] furan-5,10-dione)-dione) demonstrated the lowest MICs across the tested species. The MIC of IVS320 was particularly low for dermatophytes (values ranging from 5-28 μg/mL) and Cryptococcus spp. (3-5 μg/mL). In preliminary mechanism-of-action tests, IVS320 did not alter the fungal cell wall but did cause problems in terms of cell membrane permeability (efflux of K+ and leakage of substances that absorb at 260 nm). This last effect was unrelated to ergosterol interactions with the membrane.

Stereoplotting Hominid Brain Endocasts : Some Preliminary Results

NASA Astrophysics Data System (ADS)

Holloway, Ralph L.

1980-07-01

To objectively and quantitatively demonstrate regional differences in brain endocast morphology, traditional anthropometric caliper measurements must be replaced by a system providing not only localness, but homology and reasonable freedom from allometric distortion. Stereoplotting the radial distances from endocast surface (the closest point to the once underlying brain cortex) to a homologous center every ten degrees provides some 300+ data points for each dorsal endocast surface, thus giving the requisite localness. These measurements provide a large matrix of data suitable for a number of multivariate statistical techniques, and the translation of such data and analyses to readily visualized maps, which can then be compared in relation to both taxonomic and functional knowledge about the cerebral surface. This paper descri-bes some preliminary results from using such methods on a sample of 64 undistorted endocasts composed of both pongids and fossil hominids. While sample sizes within taxonomic groups need to be augmented, the preliminary and tentative pilot studies conducted so far suggest that the method has excellent potential, and that two major areas of the brain endocast surface show the greatest shape changes : 1) the posterior association areas (inferior parietal lobule); 2) the anterior prefrontal areas.

Handheld optical coherence tomography-reflectance confocal microscopy probe for detection of basal cell carcinoma and delineation of margins

NASA Astrophysics Data System (ADS)

Iftimia, Nicusor; Yélamos, Oriol; Chen, Chih-Shan J.; Maguluri, Gopi; Cordova, Miguel A.; Sahu, Aditi; Park, Jesung; Fox, William; Alessi-Fox, Christi; Rajadhyaksha, Milind

2017-07-01

We present a hand-held implementation and preliminary evaluation of a combined optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) probe for detecting and delineating the margins of basal cell carcinomas (BCCs) in human skin in vivo. A standard OCT approach (spectrometer-based) with a central wavelength of 1310 nm and 0.11 numerical aperture (NA) was combined with a standard RCM approach (830-nm wavelength and 0.9 NA) into a common path hand-held probe. Cross-sectional OCT images and enface RCM images are simultaneously displayed, allowing for three-dimensional microscopic assessment of tumor morphology in real time. Depending on the subtype and depth of the BCC tumor and surrounding skin conditions, OCT and RCM imaging are able to complement each other, the strengths of each helping overcome the limitations of the other. Four representative cases are summarized, out of the 15 investigated in a preliminary pilot study, demonstrating how OCT and RCM imaging may be synergistically combined to more accurately detect BCCs and more completely delineate margins. Our preliminary results highlight the potential benefits of combining the two technologies within a single probe to potentially guide diagnosis as well as treatment of BCCs.

Influence of preliminary deformation on the hardening effect upon aging of Al-Cu-Li alloys

NASA Astrophysics Data System (ADS)

Betsofen, S. Ya.; Ashmarin, A. A.; Knyazev, M. I.; Dolgova, M. I.

2016-09-01

The influence of preliminary deformation upon rolling of wedge specimens on the mechanical properties and the structural phase state of Al-Cu-Li alloys are studied by X-ray diffraction and hardness measurements. Strong dependence of the hardening effect upon aging on the reduction upon rolling has been revealed. Deformation weakly influences the hardness and significantly increases the hardening upon aging. Herewith, the hardening effect is nearly absent at the minimum deformation ratio of 1% and increases with its increase. It is demonstrated that the content of T1 phase increases from 2 to 4% in the range of a preliminary deformation ratio of 6-10% and the content of δ' phase is 17% at a deformation ratio in the range 1‒6% and increases to 18-19% at a deformation ratio of 6-10%. The δ' phase in an alloy contains <20% nanocrystalline particles with 6-20 nm in size, and the remaining part consists of amorphous particles (as detected by X-ray diffraction) <5 nm in size, which precipitate coherently from the matrix and have the same orientation as the nanocrystalline particles and the solid solution.

Effectiveness of a 10-week tier-1 response to intervention program in improving fine motor and visual-motor skills in general education kindergarten students.

PubMed

Ohl, Alisha M; Graze, Hollie; Weber, Karen; Kenny, Sabrina; Salvatore, Christie; Wagreich, Sarah

2013-01-01

This study examined the efficacy of a 10-wk Tier 1 Response to Intervention (RtI) program developed in collaboration with classroom teachers to improve the fine motor and visual-motor skills of general education kindergarten students. We recruited 113 students in six elementary schools. Two general education kindergarten classrooms at each school participated in the study. Classrooms were randomly assigned to the intervention and control groups. Fine motor skills, pencil grip, and visual-motor integration were measured at the beginning of the school year and after the 10-wk intervention. The intervention group demonstrated a statistically significant increase in fine motor and visual-motor skills, whereas the control group demonstrated a slight decline in both areas. Neither group demonstrated a change in pencil grip. This study provides preliminary evidence that a Tier 1 RtI program can improve fine motor and visual-motor skills in kindergarten students. Copyright © 2013 by the American Occupational Therapy Association, Inc.

Changes in autistic trait indicators in parents and their children with ASD: A preliminary longitudinal study.

PubMed

Hasegawa, Chiaki; Kikuchi, Mitsuru; Yoshimura, Yuko; Hiraishi, Hirotoshi; Munesue, Toshio; Takesaki, Natsumi; Higashida, Haruhiro; Oi, Manabu; Minabe, Yoshio; Asada, Minoru

2015-08-30

This study investigated whether the longitudinal changes in symptom severity in children with autism spectrum disorder (ASD) are associated with changes in the parents׳ autistic traits. The results demonstrated two significant correlations between the changes in children׳s Social Responsiveness Scale (SRS) scores and the Social Responsiveness Scale (SRS) score changes in either the father or both parents. Autistic symptom mitigation in ASD children was associated with increased empathy levels in their parents. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

[Genetic study of bacteriophage phi81. I. Isolation, study of complementation and preliminary mapping of amber-mutants of bacteriophage phi81].

PubMed

Sineokiĭ, S P; Pogosov, V Z; Iankovskiĭ, N K; Krylov, V N

1976-01-01

123 Amber mutants of lambdoid bacteriophage phi81 are isolated and distributed into 19 complementation groups. Deletion mapping made possible to locate 5 gene groups on the genetic map of bacteriophage phi81 and to determine a region of possible location of mm' sticky ends on the prophage genetic map. A gene of phage phi81 is localized, which controls the adsorption specificity, and which functional similarity to a respective gene of phage phi80 is demonstrated.

Learning Laboratory Chemistry through Electronic Sensors, a Microprocessor, and Student Enabling Software: A Preliminary Demonstration

ERIC Educational Resources Information Center

Zhang, Qing; Brode, Ly; Cao, Tingting; Thompson, J. E.

2017-01-01

We describe the construction and initial demonstration of a new instructional tool called ROXI (Research Opportunity through eXperimental Instruction). The system interfaces a series of electronic sensors to control software via the Arduino platform. The sensors have been designed to enable low-cost data collection in laboratory courses. Data are…

Parenchymal Texture Analysis in Digital Breast Tomosynthesis for Breast Cancer Risk Estimation: A Preliminary Study

PubMed Central

Kontos, Despina; Bakic, Predrag R.; Carton, Ann-Katherine; Troxel, Andrea B.; Conant, Emily F.; Maidment, Andrew D.A.

2009-01-01

Rationale and Objectives Studies have demonstrated a relationship between mammographic parenchymal texture and breast cancer risk. Although promising, texture analysis in mammograms is limited by tissue superimposition. Digital breast tomosynthesis (DBT) is a novel tomographic x-ray breast imaging modality that alleviates the effect of tissue superimposition, offering superior parenchymal texture visualization compared to mammography. Our study investigates the potential advantages of DBT parenchymal texture analysis for breast cancer risk estimation. Materials and Methods DBT and digital mammography (DM) images of 39 women were analyzed. Texture features, shown in studies with mammograms to correlate with cancer risk, were computed from the retroareolar breast region. We compared the relative performance of DBT and DM texture features in correlating with two measures of breast cancer risk: (i) the Gail and Claus risk estimates, and (ii) mammographic breast density. Linear regression was performed to model the association between texture features and increasing levels of risk. Results No significant correlation was detected between parenchymal texture and the Gail and Claus risk estimates. Significant correlations were observed between texture features and breast density. Overall, the DBT texture features demonstrated stronger correlations with breast percent density (PD) than DM (p ≤0.05). When dividing our study population in groups of increasing breast PD, the DBT texture features appeared to be more discriminative, having regression lines with overall lower p-values, steeper slopes, and higher R2 estimates. Conclusion Although preliminary, our results suggest that DBT parenchymal texture analysis could provide more accurate characterization of breast density patterns, which could ultimately improve breast cancer risk estimation. PMID:19201357

19 CFR 111.59 - Preliminary proceedings.

Code of Federal Regulations, 2010 CFR

2010-04-01

... submissions and demonstrations of the character contemplated by the cited statutory provisions; (6) Invites... into; (7) Advises the broker of his right to be represented by counsel; (8) Specifies the place where...

Feasibility, safety, and preliminary efficacy of Low Amplitude Seizure Therapy (LAP-ST): A proof of concept clinical trial in man.

PubMed

Youssef, Nagy A; Sidhom, Emad

2017-11-01

Current pulse amplitude used in clinical ECT may be higher than needed. Reducing pulse amplitude may improve focality of the electric field and thus cognitive adverse effects. Here we examine the feasibility, safety, and whether Low Pulse Amplitude Seizure Therapy (LAP-ST, 0.5-0.6A) minimizes cognitive adverse effects while retaining efficacy. Patients with treatment-resistant primary mood (depressive episodes) or psychotic disorders who were clinically indicated to undergo ECT were offered to be enrolled in an open-label study. The study consisted of a full acute course of LAP-ST under standard anesthesia and muscle relaxation. The primary outcome was feasibility of seizure induction. Clinical outcome measures were: time to reorientation (TRO), Mini Mental State Examination, Montgomery Aberg Depression Scale, and Brief Psychiatric Rating Scale, and Clinical Global Impression Scale. Twenty-two patients consented for enrollment in the study. LAP-ST was feasible, and all patients had seizures in the first session. Participants had a quick orientation with median TRO of 4.5min. Treatment was efficacious for both depressive and psychotic symptoms. Relatively small sample size, non-blinded, and no randomization was performed in this initial proof of concept study. This first human preliminary data of a full course of focal LAP-ST demonstrates that seizure induction is feasible. These results, although preliminary, suggest that the LAP-ST compared to the standard ECT techniques may result in less cognitive side effects, but comparable efficacy. Larger studies are needed to replicate these findings. Copyright © 2017 Elsevier B.V. All rights reserved.

Supercritical water oxidation of products of human metabolism

NASA Technical Reports Server (NTRS)

Tester, Jefferson W.; Orge A. achelling, Richard K. ADTHOMASSON; Orge A. achelling, Richard K. ADTHOMASSON

1986-01-01

Although the efficient destruction of organic material was demonstrated in the supercritical water oxidation process, the reaction kinetics and mechanisms are unknown. The kinetics and mechanisms of carbon monoxide and ammonia oxidation in and reaction with supercritical water were studied experimentally. Experimental oxidation of urine and feces in a microprocessor controlled system was performed. A minaturized supercritical water oxidation process for space applications was design, including preliminary mass and energy balances, power, space and weight requirements.

The Army Ambulatory Care Data Base (ACDB) Study: Implementation and Preliminary Data

DTIC Science & Technology

1988-09-01

NUMBNESS/T1’NGLING 009919 COLD INJURY - 55891 DIARRHEA (’(73449 PARALYSIS 00929 HEAT INJURY - 55890 GASTITOENTERITiS C) C)7803 SEIZURE DISORDER...illnesses or injuries which had resolved themselves or to indicate that there was no discernible illness/ injury present. Unfortunately, this problem was not...34normal state" or "feared condition was not demonstrated." It was believed that certain occurrences of injury or illness would not be supportable and

Directing Spinal Cord Plasticity: The Impact of Stretch Therapy on Functional Recovery after Spinal Cord Injury

DTIC Science & Technology

2013-10-01

of this award, we have found that stretching negatively influences locomotor function in animals with both acute (within days) and chronic (after 3...stretching is stopped, and both acute and chronic animals show a similar time course of recovery. Finally, in very preliminary studies, we have found...glove, data acquisition system and software work very well. The results demonstrate that forces about the ankle of the rat during therapeutic

A preliminary study of the tropical water cycle and its sensitivity to surface warming

NASA Technical Reports Server (NTRS)

Lau, K. M.; Sui, C. H.; Tao, W. K.

1993-01-01

The Goddard Cumulus Ensemble Model (GCEM) has been used to demonstrate that cumulus-scale dynamics and microphysics play a major role in determining the vertical distribution of water vapor and clouds in the tropical atmosphere. The GCEM is described and is the basic structure of cumulus convection. The long-term equilibrium response to tropical convection to surface warming is examined. A picture of the water cycle within tropical cumulus clusters is developed.

Fourier transform Raman spectroscopy and archaeology: a preliminary study of human teeth

NASA Astrophysics Data System (ADS)

Edwards, Howell G.; Farwell, Dennis W.; Roberts, Charlotte A.; Williams, Adrian C.

1994-01-01

The FT-Raman spectra of human bones and teeth in archaeological specimens dating to the 4th and 10th centuries AD from Romano-British and Anglo-Saxon burial sites in the U.K. have been recorded successfully using microscopic and remote sensing techniques. The samples exhibit fluorescence ascribed to mineral absorption from the grave soils but, nevertheless, good quality spectra are obtained. The versatility of the technique for non destructive sampling is demonstrated.

Geostationary platform systems concepts definition study. Volume 2: Technical, book 3

NASA Technical Reports Server (NTRS)

1980-01-01

The supporting research and technology, and space demonstrations required to support the 1990s operational geostationary platforms are identified. Also the requirements on and interfaces with the Space Transportation System hardware elements supporting the geostationary platform program, including the shuttle, orbital transfer vehicles, teleoperator, etc., are investigated to provide integrated support requirements. Finally, a preliminary evaluation of the practicability and capabilities of an experimental platform from the standpoint of technology, schedule, and cost is given.

New cassane diterpenes from Caesalpinia echinata.

PubMed

Cota, Betania Barros; de Oliveira, Djalma Menezes; de Siqueira, Ezequias Pessoa; Souza-Fagundes, Elaine Maria; Pimenta, Adriano M C; Santos, Daniel M; Rabello, Ana; Zani, Carlos Leomar

2011-10-01

An investigation of the ethanolic extract from stems of Caesalpinia echinata Lam (Leguminosae-Caesalpinioideae) led to the isolation of five new cassane diterpenes along with known lambertianic acid. Their structures were determined based on spectroscopic methods. A preliminary study on leishmanicidal activity demonstrated that compounds 1, 2 and 6 were found to inhibit the growth of amastigote-like forms of Leishmania amazonensis without affecting mononuclear cells obtained from human peripheral blood. Copyright © 2011 Elsevier B.V. All rights reserved.

Reaction of azides and enolisable aldehydes under the catalysis of organic bases and Cinchona based quaternary ammonium salts.

PubMed

Destro, Dario; Sanchez, Sandra; Cortigiani, Mauro; Adamo, Mauro F A

2017-06-21

Herein we report a two-step sequence for the preparation of amides starting from azides and enolisable aldehydes. The reaction proceeded via the formation of triazoline intermediates that were converted into amides via Lewis acid catalysis. Preliminary studies on the preparation of triazolines under chiral phase transfer catalysis are also presented, demonstrating that enantioenriched amides could be prepared from achiral aldehydes in moderate to low enantioselectivity.

Evaluations of Extended-Range tropical Cyclone Forecasts in the Western North Pacific by using the Ensemble Reforecasts: Preliminary Results

NASA Astrophysics Data System (ADS)

Tsai, Hsiao-Chung; Chen, Pang-Cheng; Elsberry, Russell L.

2017-04-01

The objective of this study is to evaluate the predictability of the extended-range forecasts of tropical cyclone (TC) in the western North Pacific using reforecasts from National Centers for Environmental Prediction (NCEP) Global Ensemble Forecast System (GEFS) during 1996-2015, and from the Climate Forecast System (CFS) during 1999-2010. Tsai and Elsberry have demonstrated that an opportunity exists to support hydrological operations by using the extended-range TC formation and track forecasts in the western North Pacific from the ECMWF 32-day ensemble. To demonstrate this potential for the decision-making processes regarding water resource management and hydrological operation in Taiwan reservoir watershed areas, special attention is given to the skill of the NCEP GEFS and CFS models in predicting the TCs affecting the Taiwan area. The first objective of this study is to analyze the skill of NCEP GEFS and CFS TC forecasts and quantify the forecast uncertainties via verifications of categorical binary forecasts and probabilistic forecasts. The second objective is to investigate the relationships among the large-scale environmental factors [e.g., El Niño Southern Oscillation (ENSO), Madden-Julian Oscillation (MJO), etc.] and the model forecast errors by using the reforecasts. Preliminary results are indicating that the skill of the TC activity forecasts based on the raw forecasts can be further improved if the model biases are minimized by utilizing these reforecasts.

Preliminary evaluation of the sensitivity to change of DE-STA motor unit number estimation in the upper trapezius muscle in amyotrophic lateral sclerosis.

PubMed

Ives, Colleen T; Findlater, Karen; Shoesmith, Christen L; Doherty, Timothy J

2015-07-01

To compare the sensitivity to change of decomposition-enhanced spike-triggered averaging (DE-STA) motor unit number estimation (MUNE) in the upper trapezius (UT) to that of various clinical outcome measures in subjects with amyotrophic lateral sclerosis (ALS). Ten patients with clinically probable or definite ALS were assessed at baseline, 2, 4 and 6months with the following outcome measures: manual muscle testing in five upper extremity muscle groups, scapular elevation and elbow flexion peak force measured with hand-held dynamometry, MUNE, forced vital capacity and the Revised ALS Functional Rating Scale (ALSFRS-R). ALSFRS-R was the only outcome measure for which there was a significant difference between baseline and 6months (p=0.034). ALSFRS-R had the largest standardized response mean (SRM), and was thus the most sensitive to change. MUNE demonstrated a decline over 6months and a moderate SRM (-0.63). This study has demonstrated a moderate degree of sensitivity to change for DE-STA MUNE as applied to the UT in subjects with ALS. In this preliminary study, DE-STA MUNE detected motor unit loss over 6months, with a moderate degree of sensitivity, in the upper trapezius of subjects with ALS. Copyright © 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Inhaled antibiotics for lower respiratory tract infections: focus on ciprofloxacin.

PubMed

Serisier, D J

2012-05-01

The administration of antibiotics by the inhaled route offers an appealing and logical approach to treating infectious respiratory conditions. Studies in the cystic fibrosis (CF) population have established the efficacy of this therapeutic concept and inhaled antibiotic therapy is now one of the pillars of management in CF. There are now a number of new inhaled antibiotic formulations that have shown impressive preliminary evidence for efficacy in CF and are commencing phase III efficacy studies. Translation of this paradigm into the non-CF bronchiectasis population has proven difficult thus far, apparently due to problems with tolerability of inhaled formulations. Inhaled versions of ciprofloxacin have shown good tolerability and microbiological efficacy in preliminary studies, suggesting that effective inhaled antibiotics are finally on the horizon for this previously neglected patient population. The increased use of long-term inhaled antibiotics for a wider range of non-CF indications presents risks to the broader community of greater antimicrobial resistance development that must be carefully weighed against any demonstrated benefits. Copyright 2012 Prous Science, S.A.U. or its licensors. All rights reserved.

Large scale prop-fan structural design study. Volume 2: Preliminary design of SR-7

NASA Technical Reports Server (NTRS)

Billman, L. C.; Gruska, C. J.; Ladden, R. M.; Leishman, D. K.; Turnberg, J. E.

1988-01-01

In recent years, considerable attention has been directed toward improving aircraft fuel consumption. Studies have shown that the inherent efficiency advantage that turboprop propulsion systems have demonstrated at lower cruise speeds may now be extended to the higher speeds of today's turbofan and turbojet-powered aircraft. To achieve this goal, new propeller designs will require features such as thin, high speed airfoils and aerodynamic sweep, features currently found only in wing designs for high speed aircraft. This is Volume 2 of a 2 volume study to establish structural concepts for such advanced propeller blades, to define their structural properties, to identify any new design, analysis, or fabrication techniques which were required, and to determine the structural tradeoffs involved with several blade shapes selected primarily on the basis of aero/acoustic design considerations. The feasibility of fabricating and testing dynamically scaled models of these blades for aeroelastic testing was also established. The preliminary design of a blade suitable for flight use in a testbed advanced turboprop was conducted and is described.

The Mothers and Toddlers Program, an attachment-based parenting intervention for substance using women: Post-treatment results from a randomized clinical pilot

PubMed Central

Suchman, Nancy E.; DeCoste, Cindy; Castiglioni, Nicole; McMahon, Thomas J.; Rounsaville, Bruce; Mayes, Linda

2010-01-01

This is a report of post-treatment findings from a completed randomized pilot study testing the preliminary efficacy of The Mothers and Toddlers Program (MTP), a 12 week attachment-based individual parenting therapy for mothers enrolled in substance abuse treatment and caring for children ages birth to 36 months. Forty-seven mothers were randomized to MTP versus the Parent Education Program (PE) – a comparison intervention providing individual case management and child guidance brochures. At post-treatment, MTP mothers demonstrated better reflective functioning in the Parent Development Interview, representational coherence and sensitivity, and caregiving behavior than PE mothers. Partial support was also found for proposed mechanisms of change in the MTP model. Together, preliminary findings suggest that attachment-based interventions may be more effective than traditional parent training for enhancing relationships between substance using women and their young children. PMID:20730641

Combined spectral-domain optical coherence tomography and hyperspectral imaging applied for tissue analysis: Preliminary results

NASA Astrophysics Data System (ADS)

Dontu, S.; Miclos, S.; Savastru, D.; Tautan, M.

2017-09-01

In recent years many optoelectronic techniques have been developed for improvement and the development of devices for tissue analysis. Spectral-Domain Optical Coherence Tomography (SD-OCT) is a new medical interferometric imaging modality that provides depth resolved tissue structure information with resolution in the μm range. However, SD-OCT has its own limitations and cannot offer the biochemical information of the tissue. These data can be obtained with hyperspectral imaging, a non-invasive, sensitive and real time technique. In the present study we have combined Spectral-Domain Optical Coherence Tomography (SD-OCT) with Hyperspectral imaging (HSI) for tissue analysis. The Spectral-Domain Optical Coherence Tomography (SD-OCT) and Hyperspectral imaging (HSI) are two methods that have demonstrated significant potential in this context. Preliminary results using different tissue have highlighted the capabilities of this technique of combinations.

Design study of wind turbines, 50 kW to 3000 kW for electric utility applications: Executive summary

NASA Technical Reports Server (NTRS)

1977-01-01

Preliminary designs of low power (50 to 500 kW) and high power (500 to 3000 kW) wind generator systems (WGS) for electric utility applications were developed. These designs provide the bases for detail design, fabrication, and experimental demonstration testing of these units at selected utility sites. Several feasible WGS configurations were evaluated, and the concept offering the lowest energy cost potential and minimum technical risk for utility applications was selected. The selected concept was optimized utilizing a parametric computer program prepared for this purpose. The utility requirements evaluation task examined the economic, operational and institutional factors affecting the WGS in a utility environment, and provided additional guidance for the preliminary design effort. Results of the conceptual design task indicated that a rotor operating at constant speed, driving an AC generator through a gear transmission is the most cost effective WGS configuration.

First Preliminary Report on Isolation and Characterization of Novel Acinetobacter spp. in Casing Soil Used for Cultivation of Button Mushroom, Agaricus bisporus (Lange) Imbach

PubMed Central

Choudhary, D. K.

2011-01-01

Despite evaluation of large number of agroindustrial wastes for their use as casing material for Agaricus bisporus (Lange) Imbach cultivation, scant attention has been given to the importance of biological properties of casing materials. In the present study, an attempt was made to characterize the bacterial flora in casing layer, namely, Farm Yard Manure (FYM) and Spent Mushroom Substrate/spent compost (SMS/SC) (FYM+SC, 3 : 1) and FYM and Vermi Compost (VC) (FYM+VC, 3 : 1), employing partial 16S rDNA sequencing. Available data showed a significant variety of organisms that included Acinetobacter and Pseudomonas of the γ-proteobacteria, that were the most frequently encountered genera. This is the first preliminary report on the microbial diversity of casing soils and demonstrates the presence of Acinetobacter spp. that has not been previously described in casing material. PMID:22007222

Economic Analysis in the Pacific Northwest Land Resources Project: Theoretical Considerations and Preliminary Results

NASA Technical Reports Server (NTRS)

Morse, D. R. A.; Sahlberg, J. T.

1977-01-01

The Pacific Northwest Land Resources Inventory Demonstration Project i s an a ttempt to combine a whole spectrum of heterogeneous geographic, institutional and applications elements in a synergistic approach to the evaluation of remote sensing techniques. This diversity is the prime motivating factor behind a theoretical investigation of alternative economic analysis procedures. For a multitude of reasons--simplicity, ease of understanding, financial constraints and credibility, among others--cost-effectiveness emerges as the most practical tool for conducting such evaluation determinatIons in the Pacific Northwest. Preliminary findings in two water resource application areas suggest, in conformity with most published studies, that Lands at-aided data collection methods enjoy substantial cost advantages over alternative techniques. The pntential for sensitivity analysis based on cost/accuracy tradeoffs is considered on a theoretical plane in the absence of current accuracy figures concerning the Landsat-aided approach.

Hardware demonstration of flexible beam control

NASA Technical Reports Server (NTRS)

Schaechter, D. B.

1980-01-01

An experiment employing a pinned-free flexible beam has been constructed to demonstrate and verify several facets of the control of flexible structures. The desired features of the experiment are to demonstrate active shape control, active dynamic control, adaptive control, various control law design approaches, and associated hardware requirements and mechanization difficulties. This paper contains the analytical work performed in support of the facility development, the final design specifications, control law synthesis, and some preliminary results.

Field investigation of the drift shadow

USGS Publications Warehouse

Su, G.W.; Kneafsey, T.J.; Ghezzehei, T.A.; Cook, P.J.; Marshall, B.D.

2006-01-01

The "Drift Shadow" is defined as the relatively drier region that forms below subsurface cavities or drifts in unsaturated rock. Its existence has been predicted through analytical and numerical models of unsaturated flow. However, these theoretical predictions have not been demonstrated empirically to date. In this project we plan to test the drift shadow concept through field investigations and compare our observations to simulations. Based on modeling studies we have an identified a suitable site to perform the study at an inactive mine in a sandstone formation. Pretest modeling studies and preliminary characterization of the site are being used to develop the field scale tests.

[The Prevalence and Risk Factors of Dementia in Centenarians].

PubMed

Arai, Yasumichi

2017-07-01

Centenarians are less susceptible to the diseases, functional losses and dependencies related to old age than the general public, and are therefore regarded as model cases of successful aging. For this reason, an important focus of the study of centenarians is their relative resilience to age-related cognitive decline or dementia. In the Tokyo Centenarian Study, we found approximately 60% of centenarians to have dementia; however, supercentenarians (those people living at least 110 years) maintained normal cognitive function at 100 years of age. Our preliminary data also demonstrated extremely low frequencies of the apolipoprotein E4 allele in supercentenarians. Moreover, postmortem brain samples from supercentenarians demonstrated relatively mild age-related neuropathological findings. Therefore, a more extensive investigation of supercentenarian populations might provide insight into successful brain aging.

Viscous drop collisions on surfaces of varying wettability

NASA Astrophysics Data System (ADS)

Bolleddula, Daniel; Berchielli, Al; Aliseda, Alberto

2010-11-01

We present an experimental study of increasingly viscous acetone rich and Newtonian equivalent liquid drops colliding on surfaces of varying wettability. This class of liquids applies directly to spray coating processes in pharmaceutical industries. The results from this study will elucidate the physics in a regime where resisting viscous forces and the restoring forces of capillarity are balanced, Oh˜ 1. Early spreading dynamics τ=Ut/D 1 indicate negligible dependence on contact angles while longer times demonstrate deviations from Tanner's law, D˜t^1/10. We will compare our results with recent theory to demonstrate the feasibility of modelling complex rheology spreading characteristics over short and long time scales. Preliminary results indicate an intermediate spreading regime following the inertial phase where the diameter, D˜t^n with 1/7 < n < 1/5.

Utility of Social Modeling for Proliferation Assessment - Preliminary Assessment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coles, Garill A.; Gastelum, Zoe N.; Brothers, Alan J.

2009-06-01

This Preliminary Assessment draft report will present the results of a literature search and preliminary assessment of the body of research, analysis methods, models and data deemed to be relevant to the Utility of Social Modeling for Proliferation Assessment research. This report will provide: 1) a description of the problem space and the kinds of information pertinent to the problem space, 2) a discussion of key relevant or representative literature, 3) a discussion of models and modeling approaches judged to be potentially useful to the research, and 4) the next steps of this research that will be pursued based onmore » this preliminary assessment. This draft report represents a technical deliverable for the NA-22 Simulations, Algorithms, and Modeling (SAM) program. Specifically this draft report is the Task 1 deliverable for project PL09-UtilSocial-PD06, Utility of Social Modeling for Proliferation Assessment. This project investigates non-traditional use of social and cultural information to improve nuclear proliferation assessment, including nonproliferation assessment, proliferation resistance assessments, safeguards assessments and other related studies. These assessments often use and create technical information about the State’s posture towards proliferation, the vulnerability of a nuclear energy system to an undesired event, and the effectiveness of safeguards. This project will find and fuse social and technical information by explicitly considering the role of cultural, social and behavioral factors relevant to proliferation. The aim of this research is to describe and demonstrate if and how social science modeling has utility in proliferation assessment.« less

An overview on the characterization and mechanical behavior of nanoporous Gold

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hodge, A M; Hayes, J R; Caro, J A

2005-09-13

In this paper we present what we believe are the most pressing issues in understanding the mechanical behavior of nanoporous foams. We have postulated that a gold foam presents the best candidate for a systematic study of nanoporous foams since it can be synthesized with a wide range of ligaments sizes and densities. We have also conducted preliminary tests that demonstrate (a) Au foams have a fracture behavior dictated by the ligament size, and (b) nanoporous Au is a high yield strength material. Thus, we have demonstrated the potential in developing nanoporous foams as a new class of high yieldmore » strength/low density materials.« less

Architectural Options for a Future Deep Space Optical Communications Network

NASA Technical Reports Server (NTRS)

Edwards, B. L.; Benjamin, T.; Scozzafava, J.; Khatri, F.; Sharma, J.; Parvin, B.; Liebrecht, P. E.; Fitzgerald, R. J.

2004-01-01

This paper provides an overview of different options at Earth to provide Deep Space optical communication services. It is based mainly on work done for the Mars Laser Communications Demonstration (MLCD) Project, a joint project between NASA's Goddard Space Flight Center (GSFC), the Jet Propulsion Laboratory, California Institute of Technology (JPL), and the Massachusetts Institute of Technology Lincoln Laboratory (MIT/LL). It also reports preliminary conclusions from the Tracking and Data Relay Satellite System Continuation Study at GSFC. A lasercom flight terminal will be flown on the Mars Telecommunications Orbiter (MTO) to be launched by NASA in 2009, and will be the first high rate deep space demonstration of this revolutionary technology.

An Interactive Preliminary Design System of High Speed Forebody and Inlet Flows

NASA Technical Reports Server (NTRS)

Liou, May-Fun; Benson, Thomas J.; Trefny, Charles J.

2010-01-01

This paper demonstrates a simulation-based aerodynamic design process of high speed inlet. A genetic algorithm is integrated into the design process to facilitate the single objective optimization. The objective function is the total pressure recovery and is obtained by using a PNS solver for its computing efficiency. The system developed uses existing software of geometry definition, mesh generation and CFD analysis. The process which produces increasingly desirable design in each genetic evolution over many generations is automatically carried out. A generic two-dimensional inlet is created as a showcase to demonstrate the capabilities of this tool. A parameterized study of geometric shape and size of the showcase is also presented.

Evaluation of spray injection patching.

DOT National Transportation Integrated Search

2003-01-01

A preliminary telephone survey of users of spray injection patching equipment revealed general satisfaction. In addition, a demonstration and follow-up 2-month evaluation of a rented truck-mounted unit convinced Virginia Department of Transportation ...

Lead Coolant Test Facility Systems Design, Thermal Hydraulic Analysis and Cost Estimate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Soli Khericha; Edwin Harvego; John Svoboda

2012-01-01

The Idaho National Laboratory prepared a preliminary technical and functional requirements (T&FR), thermal hydraulic design and cost estimate for a lead coolant test facility. The purpose of this small scale facility is to simulate lead coolant fast reactor (LFR) coolant flow in an open lattice geometry core using seven electrical rods and liquid lead or lead-bismuth eutectic coolant. Based on review of current world lead or lead-bismuth test facilities and research needs listed in the Generation IV Roadmap, five broad areas of requirements were identified as listed: (1) Develop and Demonstrate Feasibility of Submerged Heat Exchanger; (2) Develop and Demonstratemore » Open-lattice Flow in Electrically Heated Core; (3) Develop and Demonstrate Chemistry Control; (4) Demonstrate Safe Operation; and (5) Provision for Future Testing. This paper discusses the preliminary design of systems, thermal hydraulic analysis, and simplified cost estimate. The facility thermal hydraulic design is based on the maximum simulated core power using seven electrical heater rods of 420 kW; average linear heat generation rate of 300 W/cm. The core inlet temperature for liquid lead or Pb/Bi eutectic is 4200 C. The design includes approximately seventy-five data measurements such as pressure, temperature, and flow rates. The preliminary estimated cost of construction of the facility is $3.7M (in 2006 $). It is also estimated that the facility will require two years to be constructed and ready for operation.« less

Preliminary psychometric properties of the brief Negative Symptom Scale in youth at Clinical High-Risk for psychosis.

PubMed

Strauss, Gregory P; Chapman, Hannah C

2018-03-01

Preliminary psychometric properties of an adapted version of the Brief Negative Symptom Scale (BNSS) are reported in youth at Clinical High-Risk for psychosis (CHR). Participants included 29 CHR youth who met criteria for a prodromal syndrome on the Structured Interview for Prodromal Syndromes (SIPS). The adapted BNSS demonstrated excellent internal consistency, convergent validity, and discriminant validity, suggesting that the BNSS has utility for assessing negative symptoms in a CHR population. Copyright © 2017 Elsevier B.V. All rights reserved.

Analysis of Eocene depositional environments - Preliminary TM and TIMS results, Wind River Basin, Wyoming

NASA Technical Reports Server (NTRS)

Stucky, Richard K.; Krishtalka, Leonard; Redline, Andrew D.; Lang, Harold R.

1987-01-01

Both Landsat TM and aircraft Thermal IR Multispectral Scanner (TIMS) data have been used to map the lithofacies of the Wind River Basin's Eocene physical and biological environments. Preliminary analyses of these data have furnished maps of a fault contact boundary and a complex network of fluvial ribbon channel sandstones. The synoptic view thereby emerging for Eocene fluvial facies clarifies the relationships of ribbon channel sandstones to fossil-bearing overbank/floodplain facies and certain peleosols. The utility of TM and TIMS data is thereby demonstrated.

Preliminary Design Program: Vapor Compression Distillation Flight Experiment Program

NASA Technical Reports Server (NTRS)

Schubert, F. H.; Boyda, R. B.

1995-01-01

This document provides a description of the results of a program to prepare a preliminary design of a flight experiment to demonstrate the function of a Vapor Compression Distillation (VCD) Wastewater Processor (WWP) in microgravity. This report describes the test sequence to be performed and the hardware, control/monitor instrumentation and software designs prepared to perform the defined tests. the purpose of the flight experiment is to significantly reduce the technical and programmatic risks associated with implementing a VCD-based WWP on board the International Space Station Alpha.

Formal Modeling and Analysis of a Preliminary Small Aircraft Transportation System (SATS)Concept

NASA Technical Reports Server (NTRS)

Carrreno, Victor A.; Gottliebsen, Hanne; Butler, Ricky; Kalvala, Sara

2004-01-01

New concepts for automating air traffic management functions at small non-towered airports raise serious safety issues associated with the software implementations and their underlying key algorithms. The criticality of such software systems necessitates that strong guarantees of the safety be developed for them. In this paper we present a formal method for modeling and verifying such systems using the PVS theorem proving system. The method is demonstrated on a preliminary concept of operation for the Small Aircraft Transportation System (SATS) project at NASA Langley.

Helicopter Maritime Environment Trainer: Software Test Document

DTIC Science & Technology

2011-06-01

Toronto was requested by CF to investigate the potential use of low cost, virtual reality technologies for this purpose, following a successful...demonstration of these technologies for training ship handling skills and reductions of sea time. 2 DRDC Toronto TM 2011-048 Landing on...Simulator Preliminary Specification (Updated) b. DRDC Toronto Report Helicopter Deck Landing Simulator: Technology Demonstrator by F.A

Preliminary Results, Analysis and Overview of Part -1 of the GOLD Experiment

NASA Technical Reports Server (NTRS)

Wilson, K. E.; Jeganathan, M.

1996-01-01

The Ground/Orbiter Lasercomm Demonstration (GOLD) is an optical communications demonstration between Japanese Engineering Test Satellite (ETS-V1) and an optical ground transmitting and receiving station at the Table Mountain Facility in Wrightwood California. Laser transmissions to the satellite were performed approximately four hours every third night when the satellite was at above Table Mountain.

Effect of reconstructive vascular surgery on red cell deformability--preliminary results.

PubMed Central

Irwin, S T; Rocks, M J; McGuigan, J A; Patterson, C C; Morris, T C; O'Reilly, M J

1983-01-01

Using a simple filtration method, red cell deformability was measured in healthy control subjects and in patients with peripheral vascular disease. Impaired red cell deformability was demonstrated in patients with rest pain or gangrene and in patients with intermittent claudication. An improvement in red cell deformability was demonstrated after successful reconstructive vascular surgery in both patient groups. An improvement in red cell deformability was demonstrated in patients undergoing major limb amputation. PMID:6619311

Nonlocal nonlinear refraction in Hibiscus sabdariffa with large phase shifts.

PubMed

Ramírez-Martínez, D; Alvarado-Méndez, E; Trejo-Durán, M; Vázquez-Guevara, M A

2014-10-20

In this work we present a study of nonlinear optical properties in organic materials (hibiscus sabdariffa). Our results demonstrate that the medium exhibits a highly nonlocal nonlinear response. We show preliminary numerical results of the transmittance as nonlocal response by considering, simultaneously, the nonlinear absorption and refraction in media. Numerical results are accord to measurement obtained by Z- scan technique where we observe large phase shifts. We also analyze the far field diffraction ring patterns of the sample.

Are genetically robust regulatory networks dynamically different from random ones?

NASA Astrophysics Data System (ADS)

Sevim, Volkan; Rikvold, Per Arne

We study a genetic regulatory network model developed to demonstrate that genetic robustness can evolve through stabilizing selection for optimal phenotypes. We report preliminary results on whether such selection could result in a reorganization of the state space of the system. For the chosen parameters, the evolution moves the system slightly toward the more ordered part of the phase diagram. We also find that strong memory effects cause the Derrida annealed approximation to give erroneous predictions about the model's phase diagram.

Spread spectrum time-resolved diffuse optical measurement system for enhanced sensitivity in detecting human brain activity

NASA Astrophysics Data System (ADS)

Mehta, Kalpesh; Hasnain, Ali; Zhou, Xiaowei; Luo, Jianwen; Penney, Trevor B.; Chen, Nanguang

2017-04-01

Diffuse optical spectroscopy (DOS) and imaging methods have been widely applied to noninvasive detection of brain activity. We have designed and implemented a low cost, portable, real-time one-channel time-resolved DOS system for neuroscience studies. Phantom experiments were carried out to test the performance of the system. We further conducted preliminary human experiments and demonstrated that enhanced sensitivity in detecting neural activity in the cortex could be achieved by the use of late arriving photons.

Implementation of a Blowing Boundary Condition in the LAURA Code

NASA Technical Reports Server (NTRS)

Thompson, Richard a.; Gnoffo, Peter A.

2008-01-01

Preliminary steps toward modeling a coupled ablation problem using a finite-volume Navier-Stokes code (LAURA) are presented in this paper. Implementation of a surface boundary condition with mass transfer (blowing) is described followed by verification and validation through comparisons with analytic results and experimental data. Application of the code to a carbon-nosetip ablation problem is demonstrated and the results are compared with previously published data. It is concluded that the code and coupled procedure are suitable to support further ablation analyses and studies.

Cone-beam reconstruction for the two-circles-plus-one-line trajectory

NASA Astrophysics Data System (ADS)

Lu, Yanbin; Yang, Jiansheng; Emerson, John W.; Mao, Heng; Zhou, Tie; Si, Yuanzheng; Jiang, Ming

2012-05-01

The Kodak Image Station In-Vivo FX has an x-ray module with cone-beam configuration for radiographic imaging but lacks the functionality of tomography. To introduce x-ray tomography into the system, we choose the two-circles-plus-one-line trajectory by mounting one translation motor and one rotation motor. We establish a reconstruction algorithm by applying the M-line reconstruction method. Numerical studies and preliminary physical phantom experiment demonstrate the feasibility of the proposed design and reconstruction algorithm.

Numerical Studies of Optimization and Aberration Correction Methods for the Preliminary Demonstration of the Parametric Ionization Cooling (PIC) Principle in the Twin Helix Muon Cooling Channel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maloney, J. A.; Morozov, V. S.; Derbenev, Ya. S.

Muon colliders have been proposed for the next generation of particle accelerators that study high-energy physics at the energy and intensity frontiers. In this paper we study a possible implementation of muon ionization cooling, Parametric-resonance Ionization Cooling (PIC), in the twin helix channel. The resonant cooling method of PIC offers the potential to reduce emittance beyond that achievable with ionization cooling with ordinary magnetic focusing. We examine optimization of a variety of parameters, study the nonlinear dynamics in the twin helix channel and consider possible methods of aberration correction.

A prospective clinical study to evaluate the efficacy and safety of cellulite treatment using the combination of optical and RF energies for subcutaneous tissue heating.

PubMed

Sadick, Neil S; Mulholland, R Stephen

2004-12-01

There have not been any published studies on the use of radiofrequency (RF)-light-based technologies for the treatment of cellulite. Only preliminary results have recently been reported (ASDS Proceedings, September 2004). This two-center study investigated the safety and effectiveness of combined energies for cellulite treatment using the VelaSmoothtrade mark system. Thirty-five female subjects with cellulite and/or skin irregularities on the thighs and/or buttocks were treated with the VelaSmooth device. Patients received from eight to 16 treatments twice weekly. All patients maintained their normal lifestyle, and diet and fluid consumption. The circumference of the right and left medial thighs was measured at both baseline and approximately 4 weeks after the last treatment. During the last follow-up visit, the physician graded the level of improvement in skin smoothing and/or cellulite improvement using pre- and post-treatment photographs. Three patients provided biopsy specimens for histological assessment. All study patients showed some level of reduction in thigh circumference after 8 weeks of treatment; indeed, 70% of all patients showed such a reduction after 4 weeks of treatment. Also, 100% of all patients showed some level of improvement in skin texture and cellulite. The mean decrease in circumference was 0.8 inches. Some patients demonstrated reductions of more than 2 inches. There were minimal complications associated with treatment. This preliminary study demonstrates that the VelaSmooth system can have a beneficial effect on cellulite appearance. Further studies are needed to better define the mechanisms by which RF and light energies affect subdermal tissues and develop a method of quantified cellulite analysis.

76 FR 29252 - Part F Special Projects of National Significance Program Cooperative Agreement Under the Ryan...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-20

... level data from 10 demonstration sites, and disseminated preliminary descriptive information on... required human subjects research approvals. The SPNS Enhancing Linkages ESC is the best qualified Grantee...

Community Consultation and Public Disclosure: Preliminary Results From A New Model

PubMed Central

Ramsey, Cornelia A.; Quearry, Bonnie; Ripley, Elizabeth

2011-01-01

Emergency medicine research conducted under the exception from informed consent (EFIC) regulation enables critical scientific advancements. When EFIC is proposed, there is a requirement for broad community consultation and public disclosure regarding the risks and benefits of the study. At the present time, no clear guidelines or standards exist for conducting and evaluating the community consultation and public disclosure. This preliminary study tested the feasibility and acceptability of a new approach to community consultation and public disclosure for a large-scale EFIC trial by engaging community members in designing and conducting the strategies. The authors enrolled key community members (called Community Advocates for Research, or CARs) to use community-based participatory methods to design and implement community consultation and public disclosure. By partnering with community members who represent target populations for the research study, this new approach has demonstrated a feasible community consultation and public disclosure plan with greater community participation and less cost than previous studies. In a community survey, the percentage of community members reporting having heard about the EFIC trial more than doubled after employing the new approach. This article discusses initial implementation and results. PMID:21729187

Inquiry experiences as a lecture supplement for preservice elementary teachers and general education students

NASA Astrophysics Data System (ADS)

Marshall, Jill A.; Dorward, James T.

2000-07-01

The study reported here was designed to substantiate the findings of previous research on the use of inquiry-based laboratory activities in introductory college physics courses. The authors sought to determine whether limited use of inquiry activities as a supplement to a traditional lecture and demonstration curriculum would improve student achievement in introductory classes for preservice teachers and general education students. Achievement was measured by responses to problems designed to test conceptual understanding as well as overall course grades. We analyzed the effect on selected student outcome measures in a preliminary study in which some students engaged in inquiry activities and others did not, and interviewed students about their perceptions of the inquiry activities. In the preliminary study, preservice elementary teachers and female students showed significantly higher achievement after engaging such activities, but only on exam questions relating directly to the material covered in the exercises. In a second study we used a common exam problem to compare the performance of students who had engaged in a revised version of the inquiry activities with the performance of students in algebra and calculus-based classes. The students who had engaged in inquiry investigations significantly outperformed the other students.

Urban traffic-related determinants of health questionnaire (UTDHQ): an instrument developed for health impact assessments.

PubMed

Nadrian, Haidar; Nedjat, Saharnaz; Taghdisi, Mohammad Hossein; Shojaeizadeh, Davoud

2014-01-01

Traffic and transport is a substantial part of a range of economic, social and environmental factors distinguished to have impact on human health. This paper is a report on a preliminary section of a Health Impact Assessment (HIA) on urban traffic and transport initiatives, being conducted in Sanandaj, Iran. In this preliminary study, the psychometric properties of Urban Traffic related Determinants of Health Questionnaire (UTDHQ) were investigated. Multistage cluster sampling was employed to recruit 476 key informants in Sanandaj from April to June 2013 to participate in the study. The development of UTDHQ began with a comprehensive review of the literature. Then face, content and construct validity as well as reliability were determined. Exploratory Factor Analysis showed optimal reduced solution including 40 items and 8 factors. Three of the factors identified were Physical Environment, Social Environment, Public Services Delivery and Accessibility. UTDHQ demonstrated an appropriate validity, reliability, functionality and simplicity. Despite the need for further studies on UTDHQ, this study showed that it can be a practical and useful tool for conducting HIAs in order to inform decision makers and stakeholders about the health influences of their decisions and measures.

76 FR 47529 - Port Access Route Study: In the Waters of Montauk Channel and Block Island Sound

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-05

.... ACTION: Notice of availability of Preliminary Study Recommendations with request for comments. SUMMARY: The Coast Guard announces the availability of Preliminary Study Recommendations of a Port Access Route... study area. Preliminary recommendations indicate that marine transportation safety would be enhanced...

A Preliminary Investigation of a Specialized Music Therapy Model for Children with Disabilities Delivered in a Classroom Setting.

PubMed

Mendelson, Jenna; White, Yasmine; Hans, Laura; Adebari, Richard; Schmid, Lorrie; Riggsbee, Jan; Goldsmith, Ali; Ozler, Burcu; Buehne, Kristen; Jones, Sarah; Shapleton, Jennifer; Dawson, Geraldine

2016-01-01

Music therapy is gaining popularity as an intervention strategy for children with developmental disabilities, including autism spectrum disorder (ASD). This study was a pilot investigation of a classroom-based music-based intervention, Voices Together® , for improving communication skills in children with ASD and children with intellectual disabilities. Four local public elementary school special education classrooms, serving 5 children with a classification of autistic disorder and 32 children with intellectual disability without autism, were randomly selected to receive one of two levels of exposure to Voices Together music therapy: "long-term" (15 weeks beginning in January 2015 (Time 1), n = 14) or "short-term" (7 weeks beginning 7 weeks later in February (Time 2), n = 17). Using observational ratings, investigators reliably scored participants live in terms of their level of verbal responsiveness to prompts during three songs featured each week of the program. Both groups demonstrated increases in verbal responses over time; however, only the long-term group demonstrated significant within-group increases. Preliminary findings suggest that music therapy delivered in a classroom in 45-minute weekly sessions for 15 weeks can promote improvements in verbal responsiveness among individuals with autism and other developmental disabilities. Findings warrant further investigation into the efficacy of classroom-based music therapy programs.

Dirty liberals! Reminders of physical cleanliness influence moral and political attitudes.

PubMed

Helzer, Erik G; Pizarro, David A

2011-04-01

Many moral codes place a special emphasis on bodily purity, and manipulations that directly target bodily purity have been shown to influence a variety of moral judgments. Across two studies, we demonstrated that reminders of physical purity influence specific moral judgments regarding behaviors in the sexual domain as well as broad political attitudes. In Study 1, individuals in a public setting who were given a reminder of physical cleansing reported being more politically conservative than did individuals who were not given such a reminder. In Study 2, individuals reminded of physical cleansing in the laboratory demonstrated harsher moral judgments toward violations of sexual purity and were more likely to report being politically conservative than control participants. Together, these experiments provide further evidence of a deep link between physical purity and moral judgment, and they offer preliminary evidence that manipulations of physical purity can influence general (and putatively stable) political attitudes.

Computerized scintigraphic technique for the evaluation of adult respiratory distress syndrome: initial clinical trials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tatum, J.L.; Burke, T.S.; Sugerman, H.T.

1982-04-01

Eleven patients with suspected adult respiratory distress syndrome (ARDS) and five control patients were studied using a computerized gamma imaging and analysis technique and /sup 99m/Tc-labeled human serum albumin. The heart and right lung were imaged, lung:heart ratio was plotted vs. time, and a linear regression was fitted to the data points displayed. The slope of this fit was termed the ''slope index.'' An index value of 2 standard deviations greater than the control mean was considered positive. Radiographs from the six positive studies revealed typical diffuse air-space disease. Radiographs from two of the five negative studies demonstrated air-space consolidation.more » Both of these patients had elevated pulmonary capillary wedge pressure, cardiomegaly, and clinical course consistent with cardiogenic pulmonary edema. These preliminary data demonstrated a good correlation between positive slope index and clinical ARDS.« less

Computerized scintigraphic technique for the evaluation of adult respiratory distress syndrome: initial clinical trials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tatum, J.L.; Burke, T.S.; Sugerman, H.J.

1982-04-01

Eleven patients with suspected adult respiratory distress syndrome (ARDS) and five control patients were studied using a computerized gamma imaging and analysis technique and 99mTc-labeled human serum albumin. The heart and right lung were imaged, lung:heart ratio was plotted vs. time, and a linear regression was fitted to the data points displayed. The slope of this fit was termed the ''slope index.'' An index value of 2 standard deviations greater than the control mean was considered positive. Radiographs from the six positive studies revealed typical diffuse air-space disease. Radiographs from two of the five negative studies demonstrated air-space consolidation. Bothmore » of these patients had elevated pulmonary capillary wedge pressure, cardiomegaly, and clinical course consistent with cardiogenic pulmonary edema. These preliminary data demonstrated a good correlation between positive slope index and clinical ARDS.« less

Demonstration of new data types for use in interplanetary navigation

NASA Technical Reports Server (NTRS)

Ondrasik, V. J.; Chao, C. C.; Winn, F. B.; Yip, K. B.; Acton, C. H.; Reinbold, S. J.

1974-01-01

Mariner 10 was the first mission which contained many elements of the advanced navigation system which will be used in the late 1970's and 1980's. Preliminary navigation demonstrated were conducted using S/X charged particle calibrations, simultaneous Doppler data, nearly simultaneous range data, and bright object/star imaging data. The results of these demonstrations are very encouraging and a navigation system based upon these data types should be an order of magnitude better than the current system.

Geolab 2010: Desert Rats Field Demonstration

NASA Technical Reports Server (NTRS)

Evans, Cindy A.; Calaway, M. J.; Bell, M. S.

2009-01-01

In 2010, Desert Research and Technology Studies (Desert RATS), NASA's annual field exercise designed to test spacesuit and rover technologies, will include a first generation lunar habitat facility, the Habitat Demonstration Unit (HDU). The habitat will participate in joint operations in northern Arizona with the Lunar Electric Rover (LER) and will be used as a multi-use laboratory and working space. A Geology Laboratory or GeoLab is included in the HDU design. Historically, science participation in Desert RATS exercises has supported the technology demonstrations with geological traverse activities that are consistent with preliminary concepts for lunar surface science Extravehicular Activities (EVAs). Next year s HDU demonstration is a starting point to guide the development of requirements for the Lunar Surface Systems Program and test initial operational concepts for an early lunar excursion habitat that would follow geological traverses along with the LER. For the GeoLab, these objectives are specifically applied to support future geological surface science activities. The goal of our GeoLab is to enhance geological science returns with the infrastructure that supports preliminary examination, early analytical characterization of key samples, and high-grading lunar samples for return to Earth [1, 2] . Figure 1: Inside view schematic of the GeoLab a 1/8 section of the HDU, including a glovebox for handling and examining geological samples. Other outfitting facilities are not depicted in this figure. GeoLab Description: The centerpiece of the GeoLab is a glovebox, allowing for samples to be brought into the habitat in a protected environment for preliminary examination (see Fig. 1). The glovebox will be attached to the habitat bulkhead and contain three sample pass-through antechambers that would allow direct transfer of samples from outside the HDU to inside the glovebox. We will evaluate the need for redundant chambers, and other uses for the glovebox antechambers, such as a staging area for additional tools or samples. The sides of the glovebox are designed with instrument ports and additional smaller ports for cable pass-through, imagery feeds and environmental monitoring. This first glovebox version will be equipped with basic tools for manipulating, viewing, and early analysis of samples. The GeoLab was also designed for testing additional analytical instruments in a field setting.

A Domain-Decomposed Multilevel Method for Adaptively Refined Cartesian Grids with Embedded Boundaries

NASA Technical Reports Server (NTRS)

Aftosmis, M. J.; Berger, M. J.; Adomavicius, G.

2000-01-01

Preliminary verification and validation of an efficient Euler solver for adaptively refined Cartesian meshes with embedded boundaries is presented. The parallel, multilevel method makes use of a new on-the-fly parallel domain decomposition strategy based upon the use of space-filling curves, and automatically generates a sequence of coarse meshes for processing by the multigrid smoother. The coarse mesh generation algorithm produces grids which completely cover the computational domain at every level in the mesh hierarchy. A series of examples on realistically complex three-dimensional configurations demonstrate that this new coarsening algorithm reliably achieves mesh coarsening ratios in excess of 7 on adaptively refined meshes. Numerical investigations of the scheme's local truncation error demonstrate an achieved order of accuracy between 1.82 and 1.88. Convergence results for the multigrid scheme are presented for both subsonic and transonic test cases and demonstrate W-cycle multigrid convergence rates between 0.84 and 0.94. Preliminary parallel scalability tests on both simple wing and complex complete aircraft geometries shows a computational speedup of 52 on 64 processors using the run-time mesh partitioner.

Effects of exercise program on physiological functions in postmenopausal women with metabolic syndrome.

PubMed

Heli, Valkeinen; Ihab, Hajjar; Kun, Hu; Brad, Manor; Jessica, Wisocky; Vera, Novak

2013-12-01

The purpose of this study was to examine effects of mixed interval aerobic and strength training (MAST) program on physiological functions in older women with metabolic syndrome. 12 subjects were randomly assigned to the exercise group (16-week MAST program) or the control group. Outcomes included oxygen uptake (VO 2max ), cerebral blood flow velocity (BFV) and cognitive functions. The exercise group demonstrated increased VO 2max and certain improvements in cognitive functions. No changes were observed in BFV for both groups. These results can be used as a preliminary data for planning larger studies.

A numerical study of the hot gas environment around a STOVL aircraft in ground proximity

NASA Technical Reports Server (NTRS)

Vanoverbeke, Thomas J.; Holdeman, James D.

1988-01-01

The development of Short Takeoff Vertical Landing (STOVL) aircraft has historically been an empirical- and experience-based technology. In this study, a 3-D turbulent flow CFD code was used to calculate the hot gas environment around an STOVL aircraft operating in ground proximity. Preliminary calculations are reported for a typical STOVL aircraft configuration to identify key features of the flow field, and to demonstrate and assess the capability of current 3-D CFD codes to calculate the temperature of the gases ingested at the engine inlet as a function of flow and geometric conditions.

Pyropheophorbide 2-deoxyglucosamide: a new photosensitizer targeting glucose transporters.

PubMed

Zhang, Min; Zhang, Zhihong; Blessington, Dana; Li, Hui; Busch, Theresa M; Madrak, Vanessa; Miles, Jeremy; Chance, Britton; Glickson, Jerry D; Zheng, Gang

2003-01-01

To prepare near-infrared fluorescence imaging and photodynamic therapy agents targeted at glucose transporters, pyropheophorbide 2-deoxyglucosamide (Pyro-2DG) was synthesized and evaluated in a 9L glioma rat model. Fluorescence imaging studies demonstrate that Pyro-2DG is selectively accumulated in the tumor. Upon its photoactivation, we demonstrate that this agent efficiently causes selective mitochondrial damage to the region of a tumor that was photoirradiated after administration of this agent, but does not affect tissues photoirradiated in the absence of the agent or tissues treated with the agent that are not photoirradiated. Preliminary confocal microscopy studies suggest that Pyro-2DG is delivered and trapped in tumor cells via the GLUT/hexokinase pathway and therefore is useful both as a tumor-targeted NIR fluorescence imaging probe and as a PDT agent for the destruction of cancer.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chandler, K.; Eudy, L.

This report provides preliminary results from a National Renewable Energy Laboratory evaluation of a protoptye fuel cell transit bus operating at Connecticut Transit in Hartford. Included are descriptions of the planned fuel cell bus demonstration and equipment; early results and agency experience are also provided.

Ultrasonic Nakagami-parameter characterization of parotid-gland injury following head-and-neck radiotherapy: A feasibility study of late toxicity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Xiaofeng; Wu, Ning; Wang, Yuefeng

Purpose: The study aims to investigate whether Nakagami parameters—estimated from the statistical distribution of the backscattered ultrasound radio-frequency (RF) signals—could provide a means for quantitative characterization of parotid-gland injury resulting from head-and-neck radiotherapy. Methods: A preliminary clinical study was conducted with 12 postradiotherapy patients and 12 healthy volunteers. Each participant underwent one ultrasound study in which ultrasound scans were performed in the longitudinal, i.e., vertical orientation on the bilateral parotids. For the 12 patients, the mean radiation dose to the parotid glands was 37.7 ± 9.5 Gy, and the mean follow-up time was 16.3 ± 4.8 months. All enrolled patientsmore » experienced grade 1 or 2 late salivary-gland toxicity (RTOG/EORTC morbidity scale). The normal parotid glands served as the control group. The Nakagami-scaling and Nakagami-shape parameters were computed from the RF data to quantify radiation-induced parotid-gland changes. Results: Significant differences in Nakagami parameters were observed between the normal and postradiotherapy parotid glands. Compared with the control group, the Nakagami-scaling parameter of the postradiotherapy group decreased by 25.8% (p < 0.001), and the Nakagami-shape parameter decreased by 31.3% (p < 0.001). The area under the receiver operating characteristic curve was 0.85 for the Nakagami-scaling parameter and was 0.95 for the Nakagami-shape parameter, which further demonstrated the diagnostic efficiency of the Nakagami parameters. Conclusions: Nakagami parameters could be used to quantitatively measure parotid-gland injury following head-and-neck radiotherapy. Moreover, the clinical feasibility was demonstrated and this study provides meaningful preliminary data for future clinical investigation.« less

Ultrasonic Nakagami-parameter characterization of parotid-gland injury following head-and-neck radiotherapy: A feasibility study of late toxicity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Xiaofeng; Wu, Ning; Wang, Yuefeng

2014-02-15

Purpose: The study aims to investigate whether Nakagami parameters—estimated from the statistical distribution of the backscattered ultrasound radio-frequency (RF) signals—could provide a means for quantitative characterization of parotid-gland injury resulting from head-and-neck radiotherapy. Methods: A preliminary clinical study was conducted with 12 postradiotherapy patients and 12 healthy volunteers. Each participant underwent one ultrasound study in which ultrasound scans were performed in the longitudinal, i.e., vertical orientation on the bilateral parotids. For the 12 patients, the mean radiation dose to the parotid glands was 37.7 ± 9.5 Gy, and the mean follow-up time was 16.3 ± 4.8 months. All enrolled patientsmore » experienced grade 1 or 2 late salivary-gland toxicity (RTOG/EORTC morbidity scale). The normal parotid glands served as the control group. The Nakagami-scaling and Nakagami-shape parameters were computed from the RF data to quantify radiation-induced parotid-gland changes. Results: Significant differences in Nakagami parameters were observed between the normal and postradiotherapy parotid glands. Compared with the control group, the Nakagami-scaling parameter of the postradiotherapy group decreased by 25.8% (p < 0.001), and the Nakagami-shape parameter decreased by 31.3% (p < 0.001). The area under the receiver operating characteristic curve was 0.85 for the Nakagami-scaling parameter and was 0.95 for the Nakagami-shape parameter, which further demonstrated the diagnostic efficiency of the Nakagami parameters. Conclusions: Nakagami parameters could be used to quantitatively measure parotid-gland injury following head-and-neck radiotherapy. Moreover, the clinical feasibility was demonstrated and this study provides meaningful preliminary data for future clinical investigation.« less

DNA Vaccination Against Metastatic Breast Cancer

DTIC Science & Technology

2001-07-01

cells. Although DNA vaccines have shown effectiveness in clinical trials , it is essential to demonstrate pre- clinical effectiveness for anti-tumor... clinical trials for infectious diseases (4), it is essential to (5-7)demonstrate pre- clinical effectiveness for anti-tumor vaccines before clinical testing...Program Clinical Translational Research (CTR) award to perform a Phase I clinical trial of ELVIS2-neu. Our preliminary application was selected for

Demonstration of a Corner-cube-interferometer LWIR Hyperspectral Imager

NASA Astrophysics Data System (ADS)

Renhorn, Ingmar G. E.; Svensson, Thomas; Cronström, Staffan; Hallberg, Tomas; Persson, Rolf; Lindell, Roland; Boreman, Glenn D.

2010-01-01

An interferometric long-wavelength infrared (LWIR) hyperspectral imager is demonstrated, based on a Michelson corner-cube interferometer. This class of system is inherently mechanically robust, and should have advantages over Sagnac-interferometer systems in terms of relaxed beamsplitter-coating specifications, and wider unvignetted field of view. Preliminary performance data from the laboratory prototype system are provided regarding imaging, spectral resolution, and fidelity of acquired spectra.

Non destructive multi elemental analysis using prompt gamma neutron activation analysis techniques: Preliminary results for concrete sample

NASA Astrophysics Data System (ADS)

Dahing, Lahasen@Normanshah; Yahya, Redzuan; Yahya, Roslan; Hassan, Hearie

2014-09-01

In this study, principle of prompt gamma neutron activation analysis has been used as a technique to determine the elements in the sample. The system consists of collimated isotopic neutron source, Cf-252 with HPGe detector and Multichannel Analysis (MCA). Concrete with size of 10×10×10 cm3 and 15×15×15 cm3 were analysed as sample. When neutrons enter and interact with elements in the concrete, the neutron capture reaction will occur and produce characteristic prompt gamma ray of the elements. The preliminary result of this study demonstrate the major element in the concrete was determined such as Si, Mg, Ca, Al, Fe and H as well as others element, such as Cl by analysis the gamma ray lines respectively. The results obtained were compared with NAA and XRF techniques as a part of reference and validation. The potential and the capability of neutron induced prompt gamma as tool for multi elemental analysis qualitatively to identify the elements present in the concrete sample discussed.

Methodological development for 87Sr/86Sr measurement in olive oil and preliminary discussion of its use for geographical traceability of PDO Nîmes (France).

PubMed

Medini, Salim; Janin, Myriam; Verdoux, Patrick; Techer, Isabelle

2015-03-15

The lack of a geographical identification protocol for olive oils can lead to fraud and health risks. As some works call for Sr isotopes for the geographical identification of agri-food products, this study focus on the feasibility of extracting Sr from olive oils for isotopic measurements by TIMS. In fact, existing protocols for purification of Sr are unsuitable for lipid matrix. The defined protocol is applied to samples of PDO Nîmes olive oil. The accuracy of the extraction procedure is tested against isotopic standards. The values obtained are in conformity with NIST certified values. This consistency demonstrates that no modification of (87)Sr/(86)Sr ratio is brought about by this protocol. Consequently, the method is preliminary used on PDO Nîmes and Moroccan oils to evaluate the feasibility of a discriminant Sr signature on the two geographical products. This study provides promising results for the geographical discrimination and identification of PDO olive oils. Copyright © 2014 Elsevier Ltd. All rights reserved.

Laser immunotherapy for treatment of patients with advanced breast cancer and melanoma

NASA Astrophysics Data System (ADS)

Li, Xiaosong; Hode, Tomas; Guerra, Maria C.; Ferrel, Gabriela L.; Nordquist, Robert E.; Chen, Wei R.

2011-02-01

Laser immunotherapy (LIT) was developed for the treatment of metastatic tumors. It combines local selective photothermal interaction and active immunological stimulation to induce a long-term, systemic anti-tumor immunity. During the past sixteen years, LIT has been advanced from bench-top to bedside, with promising outcomes. In our pre-clinical and preliminary clinical studies, LIT has demonstrated the capability in inducing immunological responses, which not only can eradicate the treated primary tumors, but also can eliminate untreated metastases at distant sites. Specifically, LIT has been used to treat advanced melanoma and breast cancer patients during the past five years. LIT was shown to be effective in controlling both primary tumors and distant metastases in late-stage patients, who have failed conventional therapies such as surgery, chemotherapy, radiation, and other more advanced approaches. The methodology and the development of LIT are presented in this paper. The patients' responses to LIT are also reported in this paper. The preliminary results obtained in these studies indicated that LIT could be an effective modality for the treatment of patients with late-stage, metastatic cancers, who are facing severely limited options.

Use of photo-Fenton's reaction by 400-nm LED light for endodontic disinfection: A preliminary in vitro study on Enterococcus faecalis.

PubMed

Lagori, Giuseppe; Fornaini, Carlo; Rocca, Jean-Paul; Merigo, Elisabetta

2017-06-01

One of the biggest challenges in endodontics is the complete disinfection of root canals. In addition to mechanical preparation, the technique traditionally also involves channel disinfection with other agents such as sodium hypochlorite, hydrogen peroxide, chlorhexidine, or a combination of these. Some bacterial species are particularly resistant to eradication. Using Enterococcus faecalis in this preliminary study, we tested the bactericidal effectiveness of the Fenton reaction and the photo-Fenton reaction using an LED light with a 400-nm wavelength. Discs of hydroxyapatite were incubated in brain-heart broth contaminated with Enterococcus faecalis. After 4days, they were decontaminated with different bactericidal agents, including some with proven and well-known efficacy (5% sodium hypochlorite and 3% hydrogen peroxide) and other treatments using solutions of 1.5% hydrogen peroxide and 0.15% iron gluconate (Fenton reaction) plus LED light at a Fluence of 4.0J/cm 2 (photo-Fenton reaction). The photo-Fenton reaction demonstrated comparable performance to that of sodium hypochlorite in eliminating Enterococcus faecalis. Copyright © 2017. Published by Elsevier B.V.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goltz, M.N.; Hopkins, G.D.; Kawakami, B.T.

A trichloroethylene (TCE) ground water plume at Edwards AFB in Southern California is being used to demonstrate in situ aerobic cometabolic bioremediation in the field. The bioremediation system that will be demonstrated at Edwards was developed over nine years of research and testing in the laboratory and at a pilot field site located at Moffett Federal Airfield in Mountain View, California. Studies conducted at the Moffett field site have demonstrated that TCE can be effectively biodegraded cometabolically through the introduction into the subsurface of a primary substrate and an oxygen source to support the growth and energy requirements of amore » native population of microorganisms. A system to demonstrate the feasibility of in situ aerobic cometabolic bioremediation is presently being constructed at Edwards, using an area of the plume having TCE concentrations ranging up to 1 mg/L. A major objective of the Edwards study will be to investigate how a primary substrate and an oxygen source can be efficiently mixed and transported to indigenous microorganisms, in order to promote cometabolic degradation of TCE. In this presentation, the earlier studies at Moffett, as well as the preliminary modeling work and site characterization which have been conducted in preparation for the Edwards demonstration, will be presented. In addition, problems encountered and lessons learned bringing an innovative technology from the laboratory to the field will be discussed.« less

Vocal Affect Recognition and Psychopathy: Converging Findings Across Traditional and Cluster Analytic Approaches to Assessing the Construct

PubMed Central

Bagley, Amy D.; Abramowitz, Carolyn S.; Kosson, David S.

2010-01-01

Deficits in emotion processing have been widely reported to be central to psychopathy. However, few prior studies have examined vocal affect recognition in psychopaths, and these studies suffer from significant methodological limitations. Moreover, prior studies have yielded conflicting findings regarding the specificity of psychopaths’ affect recognition deficits. This study examined vocal affect recognition in 107 male inmates under conditions requiring isolated prosodic vs. semantic analysis of affective cues and compared subgroups of offenders identified via cluster analysis on vocal affect recognition. Psychopaths demonstrated deficits in vocal affect recognition under conditions requiring use of semantic cues and conditions requiring use of prosodic cues. Moreover, both primary and secondary psychopaths exhibited relatively similar emotional deficits in the semantic analysis condition compared to nonpsychopathic control participants. This study demonstrates that psychopaths’ vocal affect recognition deficits are not due to methodological limitations of previous studies and provides preliminary evidence that primary and secondary psychopaths exhibit generally similar deficits in vocal affect recognition. PMID:19413412

Multi-Criterion Preliminary Design of a Tetrahedral Truss Platform

NASA Technical Reports Server (NTRS)

Wu, K. Chauncey

1995-01-01

An efficient method is presented for multi-criterion preliminary design and demonstrated for a tetrahedral truss platform. The present method requires minimal analysis effort and permits rapid estimation of optimized truss behavior for preliminary design. A 14-m-diameter, 3-ring truss platform represents a candidate reflector support structure for space-based science spacecraft. The truss members are divided into 9 groups by truss ring and position. Design variables are the cross-sectional area of all members in a group, and are either 1, 3 or 5 times the minimum member area. Non-structural mass represents the node and joint hardware used to assemble the truss structure. Taguchi methods are used to efficiently identify key points in the set of Pareto-optimal truss designs. Key points identified using Taguchi methods are the maximum frequency, minimum mass, and maximum frequency-to-mass ratio truss designs. Low-order polynomial curve fits through these points are used to approximate the behavior of the full set of Pareto-optimal designs. The resulting Pareto-optimal design curve is used to predict frequency and mass for optimized trusses. Performance improvements are plotted in frequency-mass (criterion) space and compared to results for uniform trusses. Application of constraints to frequency and mass and sensitivity to constraint variation are demonstrated.

FIELD INVESTIGATIONS OF THE DRIFT SHADOW

DOE Office of Scientific and Technical Information (OSTI.GOV)

G. W. Su, T. J. Kneafsey, T. A. Ghezzehei, B. D. Marshall, and P. J. Cook

The ''Drift Shadow'' is defined as the relatively drier region that forms below subsurface cavities or drifts in unsaturated rock. Its existence has been predicted through analytical and numerical models of unsaturated flow. However, these theoretical predictions have not been demonstrated empirically to date. In this project they plan to test the drift shadow concept through field investigations and compare our observations to simulations. Based on modeling studies they have an identified suitable site to perform the study at an inactive mine in a sandstone formation. Pretest modeling studies and preliminary characterization of the site are being used to developmore » the field scale tests.« less

Barriers to cancer care, perceived social support, and patient navigation services for Korean breast cancer patients.

PubMed

Lim, Jung-Won

2015-01-01

The present study aimed to examine the relationships among barriers to cancer care, perceived social support, and patient navigation services (PNS) for Korean breast cancer patients. For Korean breast cancer patients, PNS are comprised of five services, including emotional, financial, information, transportation, and disease management. The study findings demonstrated that transportation and disease management barriers were directly associated with PNS, whereas emotional and financial barriers were indirectly associated with PNS through perceived social support. The current study provides a preliminary Korean patient navigation model to identify how barriers to cancer care can be reduced through social support and PNS.

The discrepancy rate between preliminary and official reports of emergency radiology studies: a performance indicator and quality improvement method.

PubMed

Issa, Ghada; Taslakian, Bedros; Itani, Malak; Hitti, Eveline; Batley, Nicholas; Saliba, Miriam; El-Merhi, Fadi

2015-05-01

At teaching hospitals, radiology residents give preliminary reports for imaging studies requested from the Emergency Department (ED). Discrepancy rates between preliminary and final reports represent an important performance indicator. To present a system for feedback and follow-up of discrepancies, identify the variables associated with the rate and severity of such discrepancies, target the weaknesses, and suggest the need of a standard reference value for comparison among institutions. A monitoring and communication system between the Department of Diagnostic Radiology and Emergency Department was initiated to mark and follow all studies from the ED for which the official reading was different than the preliminary interpretation. Data analysis was performed on all studies from 1 June 2011 to 31 May 2012, based on the severity of the discrepancy, imaging modality, resident training level, and organ system. The distribution of the number of discrepancies among the different resident levels and imaging modalities was determined, as well as the distribution of three severity scores in correlation with other variables. The overall discrepancy rate was 1.62%. The discrepancy rate was higher for first and second year residents (1.62% and 1.96%) than for third and fourth year residents (1.35% and 1.24%). It was higher for computed tomography (2.13%) than for radiographs (1.29%) and ultrasound (0.8%) (P value < 0.01), and higher for musculoskeletal (1.61%) than non-musculoskeletal (0.99%) radiographs (P value = 0.0003). Discrepancies with severity score one constituted 35.5% of the total discrepancies, those with severity scores two and three constituted 22.9% and 41.6%, respectively. We have demonstrated a system for follow-up of discrepancy in interpreting emergency radiology studies, and recorded the discrepancy rate, with further analysis based on different variables. In terms of quality assurance, a periodical analysis might help to reduce the number of discrepant reports by targeted intervention. © The Foundation Acta Radiologica 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

In vivo detection of oral epithelial cancer using endogenous fluorescence lifetime imaging: a pilot human study (Conference Presentation)

NASA Astrophysics Data System (ADS)

Jo, Javier A.; Hwang, Dae Yon; Palma, Jorge; Cheng, Shuna; Cuenca, Rodrigo; Malik, Bilal; Jabbour, Joey; Cheng, Lisa; Wright, John; Maitland, Kristen

2016-03-01

Endogenous fluorescence lifetime imaging (FLIM) provides direct access to the concomitant functional and biochemical changes accompanying tissue transition from benign to precancerous and cancerous. Since FLIM can noninvasively measure different and complementary biomarkers of precancer and cancer, we hypothesize that it will aid in clinically detecting early oral epithelial cancer. Our group has recently demonstrated the detection of benign from premalignant and malignant lesions based on endogenous multispectral FLIM in the hamster cheek-pouch model. Encouraged by these positive preliminary results, we have developed a handheld endoscope capable of acquiring multispectral FLIM images in real time from the oral mucosa. This novel FLIM endoscope is being used for imaging clinically suspicious pre-malignant and malignant lesions from patients before undergoing tissue biopsy for histopathological diagnosis of oral epithelial cancer. Our preliminary results thus far are already suggesting the potential of endogenous FLIM for distinguishing a variety of benign lesions from advanced dysplasia and squamous cell carcinoma (SCC). To the best of out knowledge, this is the first in vivo human study aiming to demonstrate the ability to predict the true malignancy of clinically suspicious lesions using endogenous FLIM. If successful, the resulting clinical tool will allow noninvasive real-time detection of epithelial precancerous and cancerous lesions in the oral mucosa and could potentially be used to assist at every step involved on the clinical management of oral cancer patients, from early screening and diagnosis, to treatment and monitoring of recurrence.

Making and Executing Decisions for Safe and Independent Living (MED-SAIL): development and validation of a brief screening tool.

PubMed

Mills, Whitney L; Regev, Tziona; Kunik, Mark E; Wilson, Nancy L; Moye, Jennifer; McCullough, Laurence B; Naik, Aanand D

2014-03-01

Older adults prefer to remain in their own homes for as long as possible. The purpose of this article is to describe the development and preliminary validation of Making and Executing Decisions for Safe and Independent Living (MED-SAIL), a brief screening tool for capacity to live safely and independently in the community. Prospective preliminary validation study. Outpatient geriatrics clinic located in a community-based hospital. Forty-nine community-dwelling older adults referred to the clinic for a comprehensive capacity assessment. We examined internal consistency, criterion-based validity, concurrent validity, and accuracy of classification for MED-SAIL. The items included in MED-SAIL demonstrated internal consistency (5 items; α = 0.85). MED-SAIL was significantly correlated with the Independent Living Scales (r = 0.573, p ≤0.001) and instrumental activities of daily living (r = 0.440, p ≤0.01). The Mann-Whitney U test revealed significant differences between the no capacity and partial/full capacity classifications on MED-SAIL (U(48) = 60.5, Z = -0.38, p <0.0001). The area under the curve was 0.864 (95% confidence interval: 0.84-0.99). This study demonstrated the validity of MED-SAIL as a brief screening tool to identify older adults with impaired capacity for remaining safe and independent in their current living environment. MED-SAIL is useful tool for health and social service providers in the community for the purpose of referral for definitive capacity evaluation. Published by Elsevier Inc.

In situ fluidization for peat bed rupture, and preliminary economic analysis.

PubMed

Niven, R K; Khalili, N

2002-11-01

This study concerns in situ fluidization (ISF), a new remediation method with potential application to the remediation of NAPL and heavy metal contaminants, by their release from the fluidized zone generated by a water jet. The present study examines the effect of ISF on layers of peat, of significance owing to its role as an important NAPL and metal contaminant trap. Once trapped, such contaminants are not readily accessible by most remedial methods, due to the low permeability and diffusivity of the peat. A simple tank experiment is used to demonstrate rupture of a peat layer by ISF, with removal of the peat as elutriated fines and segregated peat chunks. The application of ISF in the field is then examined by three field trials in uncontaminated sands, in both saturated and unsaturated conditions. Fluidized depths of up to 1.9 m in the saturated zone (with refusal on a peat layer) and 2.5 m in the unsaturated zone (no refusal) were attained, using a 1.9-m-long, 50 mm diameter jet operated at 5-13 1 s(-1). Pulses of dark turbidity and shell fragments in the effluent indicated the rupture of peat and shelly layers. The experiments demonstrate the hydraulic viability of ISF in the field, and its ability to remove peat-based contaminants. The issues of appropriate jet design and water generation during ISF are discussed, followed by a preliminary economic analysis of ISF relative to existing remediation methods.

Stress predicts brain changes in children: a pilot longitudinal study on youth stress, posttraumatic stress disorder, and the hippocampus.

PubMed

Carrion, Victor G; Weems, Carl F; Reiss, Allan L

2007-03-01

Does stress damage the brain? Studies of adults with posttraumatic stress disorder have demonstrated smaller hippocampal volumes when compared with the volumes of adults with no posttraumatic stress disorder. Studies of children with posttraumatic stress disorder have not replicated the smaller hippocampal findings in adults, which suggests that smaller hippocampal volume may be caused by neurodevelopmental experiences with stress. Animal research has demonstrated that the glucocorticoids secreted during stress can be neurotoxic to the hippocampus, but this has not been empirically demonstrated in human samples. We hypothesized that cortisol volumes would predict hippocampal volume reduction in patients with posttraumatic symptoms. We report data from a pilot longitudinal study of children (n = 15) with history of maltreatment who underwent clinical evaluation for posttraumatic stress disorder, cortisol, and neuroimaging. Posttraumatic stress disorder symptoms and cortisol at baseline predicted hippocampal reduction over an ensuing 12- to 18-month interval. Results from this pilot study suggest that stress is associated with hippocampal reduction in children with posttraumatic stress disorder symptoms and provide preliminary human evidence that stress may indeed damage the hippocampus. Additional studies seem to be warranted.

Cognitive Existential Couple Therapy for newly diagnosed prostate cancer patients and their partners: a descriptive pilot study.

PubMed

Collins, Anna L; Love, Anthony W; Bloch, Sidney; Street, Annette F; Duchesne, Gillian M; Dunai, Judy; Couper, Jeremy W

2013-02-01

This paper aims to describe 'Cognitive Existential Couple Therapy' (CECT), a novel couples-based intervention for men with early stage prostate cancer (PCa) and their partners, and to report preliminary findings from a pilot study that investigated the acceptability and feasibility of the intervention and the measures to be used in a subsequent randomised controlled trial. A manualised CECT programme was delivered to 12 couples facing a diagnosis of PCa within the previous 12 months by psychiatrists and clinical psychologists. Participants completed measures of psychological distress, marital function and coping pattern before and after CECT. Semi-structured interviews were conducted with nine couples shortly after the completion of CECT. The application of CECT was both feasible and acceptable as indicated by favourable participant compliance (10 of the 12 couples attended all six designated sessions), completion of measures before and after CECT and participation in semi-structured interviews by nine couples. Preliminary results included reduced levels of avoidance and hyperarousal after the programme, with this effect stronger in partners than in patients. Interviews demonstrated that couples valued the therapist's contribution to their overall care. Previous research suggests that a couple-focused psychological intervention is desirable in the context of early stage PCa. This pilot study has established that CECT is acceptable, feasible and valued by couples facing a recent PCa diagnosis and demonstrates a potential for reduced psychological distress following CECT. A randomised controlled trial is currently being undertaken to validate the efficacy of this novel approach. Copyright © 2011 John Wiley & Sons, Ltd.

Anaesthesiologists' views on the need for point-of-care information system in the operating room: a survey of the European Society of Anaesthesiologists.

PubMed

Perel, A; Berkenstadt, H; Ziv, A; Katzenelson, R; Aitkenhead, A

2004-11-01

In this preliminary study we wanted to explore the attitudes of anaesthesiologists to a point-of-care information system in the operating room. The study was conducted as a preliminary step in the process of developing such a system by the European Society of Anaesthesiologists (ESA). A questionnaire was distributed to all 2240 attendees of the ESA's annual meeting in Gothenburg, Sweden, which took place in April 2001. Of the 329 responders (response rate of 14.6%), 79% were qualified specialists with more than 10 yr of experience (68%), mostly from Western Europe. Most responders admitted to regularly experiencing lack of medical knowledge relating to real-time patient care at least once a month (74%) or at least once a week (46%), and 39% admitted to having made errors during anaesthesia due to lack of medical information that can be otherwise found in a handbook. The choice ofa less optimal but more familiar approach to patient management due to lack of knowledge was reported by 37%. Eighty-eight percent of responders believe that having a point-of-care information system for the anaesthesiologists in the operating room is either important or very important. This preliminary survey demonstrates that lack of knowledge of anaesthesiologists may be a significant source of medical errors in the operating room, and suggests that a point-of-care information system for the anaesthesiologist may be of value.

Using video games for volcanic hazard education and communication: an assessment of the method and preliminary results

NASA Astrophysics Data System (ADS)

Mani, Lara; Cole, Paul D.; Stewart, Iain

2016-07-01

This paper presents the findings from a study aimed at understanding whether video games (or serious games) can be effective in enhancing volcanic hazard education and communication. Using the eastern Caribbean island of St. Vincent, we have developed a video game - St. Vincent's Volcano - for use in existing volcano education and outreach sessions. Its twin aims are to improve residents' knowledge of potential future eruptive hazards (ash fall, pyroclastic flows and lahars) and to integrate traditional methods of education in a more interactive manner. Here, we discuss the process of game development including concept design through to the final implementation on St. Vincent. Preliminary results obtained from the final implementation (through pre- and post-test knowledge quizzes) for both student and adult participants provide indications that a video game of this style may be effective in improving a learner's knowledge. Both groups of participants demonstrated a post-test increase in their knowledge quiz score of 9.3 % for adults and 8.3 % for students and, when plotted as learning gains (Hake, 1998), show similar overall improvements (0.11 for adults and 0.09 for students). These preliminary findings may provide a sound foundation for the increased integration of emerging technologies within traditional education sessions. This paper also shares some of the challenges and lessons learnt throughout the development and testing processes and provides recommendations for researchers looking to pursue a similar study.

Preliminary testing of a prototype portable X-ray fluorescence spectrometer

NASA Technical Reports Server (NTRS)

Patten, L. L.; Anderson, N. B.; Stevenson, J. J.

1982-01-01

A portable X-ray fluorescence spectrometer for use as an analyzer in mineral resource investigative work was built and tested. The prototype battery powered spectrometer, measuring 11 by 12 by 5 inches and weighing only about 15 pounds, was designed specifically for field use. The spectrometer has two gas proportional counters and two radioactive sources, Cd (10a) and Fe (55). Preliminary field and laboratory tests on rock specimens and rock pulps have demonstrated the capability of the spectrometer to detect 33 elements to date. Characteristics of the system present some limitations, however, and further improvements are recommended.

Measuring appraisals following acquired spinal cord injury: a preliminary psychometric analysis of the appraisals of disability.

PubMed

Dean, R E; Kennedy, Paul

2009-05-01

The current study aimed to develop a reliable and valid appraisal scale (The Appraisals of DisAbility: Primary and Secondary Scale; ADAPSS) for adult spinal cord injury (SCI) populations. Items for the ADAPSS were generated using themes and quotes from a qualitative study exploring appraisals made by individuals with SCI. The ADAPSS was administered with 2 additional appraisal measures, a measure of anxiety and depression, a measure of social desirability and demographic information. The study used a cross-sectional questionnaire design with a test-retest component, sampling community-based individuals with SCI. Data analysis was undertaken on 237 completed questionnaires. Factor analysis revealed the ADAPSS to have a 6-factor structure and the following subscales identified: (a) Fearful Despondency, (b) Overwhelming Disbelief, (c) Determined Resolve, (d) Growth and Resilience, (e) Negative Perceptions of Disability, and (f) Personal Agency. Preliminary analyses suggest the ADAPSS demonstrates reasonable reliability and validity and has potential as a therapeutic outcome measure. Future research should focus on the relationship between appraisals identified on the ADAPSS and their relationship to the coping strategies that individuals employ and adjustment to SCI. (PsycINFO Database Record (c) 2009 APA, all rights reserved).

Preliminary study of effects of military obscurant smokes on flora and fauna during field and laboratory exposures. Final technical report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schaeffer, D.J.; Lower, W.R.; Kapila, S.

1986-12-01

Since continued routine use of obscurant smokes could be detrimental to the native flora and fauna of training sites, a preliminary biological and chemical study of smokes was conducted to determine whether tests could be developed to demonstrate measurable changes in organisms exposed to smokes and to evaluate whether short exposures to smokes produced measurable changes in the organisms tested. Fog oil, hexachloroethane, and tank diesel smokes were tested. Tradescantia clones were examined for mutagenic effects indicated by micronuclei induction in developing pollen and pink somatic mutations in stamen hairs. Photosynthetic perturbations were measured in Tradescantia and Ambrosia dumosa usingmore » variable fluorescence induction. Animals were examined for sister chromatid exchanges and chromosome aberrations. It was found that all of the smokes tested exerted varying degrees of physiological and mutagenic effects in one or several of the assay systems at one or more of the exposure distances. These studies indicate that exposed ecological systems, or at least components of these systems, are at a higher risk than are control organisms for several types of damage attributed to obscurant smoke exposure.« less

Development of a rapid diagnostic test for pertussis: direct detection of pertussis toxin in respiratory secretions.

PubMed Central

Friedman, R L; Paulaitis, S; McMillan, J W

1989-01-01

Monoclonal antibodies (MAb) were produced against the specific Bordetella pertussis antigen pertussis toxin (PT). In preliminary studies, one MAb (IB12) was selected and used in an enzyme-linked dot blot immunoassay to evaluate the ability of the method to detect known amounts of PT in control experiments and to test its potential for direct detection of PT in nasopharyngeal secretion (NP) specimens from patients with confirmed cases of whooping cough. The dot blot assay was able to detect PT at levels as low as 10 ng per dot in either buffer or control NP specimens. The assay demonstrated specificity, reacting only with dot blots of whole B. pertussis and not Bordetella bronchiseptica, Bordetella parapertussis, or other bacterial strains. In preliminary studies, NP aspirate, swab, and wash specimens were compared. The specimen of choice was found to be the NP aspirate, for which 100% positive results were found in the assay. These initial studies suggest that the dot blot immunoassay in which a MAb is used for direct detection of PT in NP specimens may be useful as a rapid diagnostic test for pertussis. Images PMID:2808670

Purification, Preliminary Characterization and Hepatoprotective Effects of Polysaccharides from Dandelion Root.

PubMed

Cai, Liangliang; Wan, Dongwei; Yi, Fanglian; Luan, Libiao

2017-08-25

In this study, purification, preliminary characterization and hepatoprotective effects of water-soluble polysaccharides from dandelion root (DRP) were investigated. Two polysaccharides, DRP1 and DRP2, were isolated from DRP. The two polysaccharides were α-type polysaccharides and didn't contain protein. DRP1, with a molecular weight of 5695 Da, was composed of glucose, galactose and arabinose, whereas DRP2, with molecular weight of 8882 Da, was composed of rhamnose, galacturonic acid, glucose, galactose and arabinose. The backbone of DRP1 was mainly composed of (1→6)-linked-α-d-Glc and (1→3,4)-linked-α-d-Glc. DRP2 was mainly composed of (1→)-linked-α-d-Ara and (1→)-linked-α-d-Glc. A proof-of-concept study was performed to assess the therapeutic potential of DRP1 and DRP2 in a mouse model that mimics acetaminophen (APAP) -induced liver injury (AILI) in humans. The present study shows DRP1 and DRP2 could protect the liver from APAP-induced hepatic injury by activating the Nrf2-Keap1 pathway. These conclusions demonstrate that the DRP1 and DRP2 might be suitable as functional foods and natural drugs in preventing APAP-induced liver injury.

Attentive Reading With Constrained Summarization Adapted to Address Written Discourse in People With Mild Aphasia.

PubMed

Obermeyer, Jessica A; Edmonds, Lisa A

2018-03-01

The purpose of this study was to examine the preliminary efficacy of Attentive Reading and Constrained Summarization-Written (ARCS-W) in people with mild aphasia. ARCS-W adapts an existing treatment, ARCS (Rogalski & Edmonds, 2008), to address discourse level writing in mild aphasia. ARCS-W focuses on the cognitive and linguistic skills required for discourse production. This study was a within-subject pre-postdesign. Three people with mild aphasia participated. ARCS-W integrates attentive reading or listening with constrained summarization of discourse level material in spoken and written modalities. Outcomes included macro- (main concepts) and microlinguistic (correct information units, complete utterances) discourse measures, confrontation naming, aphasia severity, and functional communication. All 3 participants demonstrated some generalization to untrained spoken and written discourse at the word, sentence, and text levels. Reduced aphasia severity and/or increased functional communication and confrontation naming were also observed in some participants. The findings of this study provide preliminary evidence of the efficacy of ARCS-W to improve spoken and written discourse in mild aphasia. Different generalization patterns suggest different mechanisms of improvement. Further research and replication are required to better understand how ARCS-W can impact discourse abilities.

Eliciting affect via immersive virtual reality: a tool for adolescent risk reduction.

PubMed

Hadley, Wendy; Houck, Christopher D; Barker, David H; Garcia, Abbe Marrs; Spitalnick, Josh S; Curtis, Virginia; Roye, Scott; Brown, Larry K

2014-04-01

A virtual reality environment (VRE) was designed to expose participants to substance use and sexual risk-taking cues to examine the utility of VR in eliciting adolescent physiological arousal. 42 adolescents (55% male) with a mean age of 14.54 years (SD = 1.13) participated. Physiological arousal was examined through heart rate (HR), respiratory sinus arrhythmia (RSA), and self-reported somatic arousal. A within-subject design (neutral VRE, VR party, and neutral VRE) was utilized to examine changes in arousal. The VR party demonstrated an increase in physiological arousal relative to a neutral VRE. Examination of individual segments of the party (e.g., orientation, substance use, and sexual risk) demonstrated that HR was significantly elevated across all segments, whereas only the orientation and sexual risk segments demonstrated significant impact on RSA. This study provides preliminary evidence that VREs can be used to generate physiological arousal in response to substance use and sexual risk cues.

TEXSYS. [a knowledge based system for the Space Station Freedom thermal control system test-bed

NASA Technical Reports Server (NTRS)

Bull, John

1990-01-01

The Systems Autonomy Demonstration Project has recently completed a major test and evaluation of TEXSYS, a knowledge-based system (KBS) which demonstrates real-time control and FDIR for the Space Station Freedom thermal control system test-bed. TEXSYS is the largest KBS ever developed by NASA and offers a unique opportunity for the study of technical issues associated with the use of advanced KBS concepts including: model-based reasoning and diagnosis, quantitative and qualitative reasoning, integrated use of model-based and rule-based representations, temporal reasoning, and scale-up performance issues. TEXSYS represents a major achievement in advanced automation that has the potential to significantly influence Space Station Freedom's design for the thermal control system. An overview of the Systems Autonomy Demonstration Project, the thermal control system test-bed, the TEXSYS architecture, preliminary test results, and thermal domain expert feedback are presented.

Real-time control of focused ultrasound heating based on rapid MR thermometry.

PubMed

Vimeux, F C; De Zwart, J A; Palussiére, J; Fawaz, R; Delalande, C; Canioni, P; Grenier, N; Moonen, C T

1999-03-01

Real-time control of the heating procedure is essential for hyperthermia applications of focused ultrasound (FUS). The objective of this study is to demonstrate the feasibility of MRI-controlled FUS. An automatic control system was developed using a dedicated interface between the MR system control computer and the FUS wave generator. Two algorithms were used to regulate FUS power to maintain the focal point temperature at a desired level. Automatic control of FUS power level was demonstrated ex vivo at three target temperature levels (increase of 5 degrees C, 10 degrees C, and 30 degrees C above room temperature) during 30-minute hyperthermic periods. Preliminary in vivo results on rat leg muscle confirm that necrosis estimate, calculated on-line during FUS sonication, allows prediction of tissue damage. CONCLUSIONS. The feasibility of fully automatic FUS control based on MRI thermometry has been demonstrated.

Minimally invasive periodontal therapy

PubMed Central

Dannan, Aous

2011-01-01

Minimally invasive dentistry is a concept that preserves dentition and supporting structures. However, minimally invasive procedures in periodontal treatment are supposed to be limited within periodontal surgery, the aim of which is to represent alternative approaches developed to allow less extensive manipulation of surrounding tissues than conventional procedures, while accomplishing the same objectives. In this review, the concept of minimally invasive periodontal surgery (MIPS) is firstly explained. An electronic search for all studies regarding efficacy and effectiveness of MIPS between 2001 and 2009 was conducted. For this purpose, suitable key words from Medical Subject Headings on PubMed were used to extract the required studies. All studies are demonstrated and important results are concluded. Preliminary data from case cohorts and from many studies reveal that the microsurgical access flap, in terms of MIPS, has a high potential to seal the healing wound from the contaminated oral environment by achieving and maintaining primary closure. Soft tissues are mostly preserved and minimal gingival recession is observed, an important feature to meet the demands of the patient and the clinician in the esthetic zone. However, although the potential efficacy of MIPS in the treatment of deep intrabony defects has been proved, larger studies are required to confirm and extend the reported positive preliminary outcomes. PMID:22368356

SU-F-T-678: Clotrimazole Sensitizes MCF-7 Breast Cancer Cell Line to Radiation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garcia, L; Tambasco, M

2016-06-15

Purpose: To study the effects of Clotrimazole (CLT) on radiosensitivity of MCF-7 Cells in correlation to detachment of Hexokinase II from the Voltage Dependent Anion Channel on the outer membrane of the mitochondria. Apoptotic fractions were also analyzed in relation to the detachment of Hexokinase. Methods: This study focused on the mammary adenocarcinoma cell line, MCF-7. Colony forming assays were used to analyze radiosensitization by CLT. Flow cytometry methods were used to analyze apoptotic vs necrotic fractions after treatment with CLT. Spectrophotometery was used to analyze the mitochondrial bound and soluble fraction of Hexokinase by means of relative enzymatic activity.more » Results: Our preliminary data have shown that CLT sensitizes MCF-7 cells to radiation in a dose and incubation time dependent manner up. We have also demonstrated that there are two radiosensitizing periods in MCF-7 cells with the first corresponding to the cycle arrest after 24 hours observed in other cell lines. The second radiosensitizing period occurs with incubation in CLT after irradiation which reaches maximum effect around 24 hours of incubation time. Preliminary data from our Hexokinase detachment assay show a factor of two increase in the ratio of unbound to bound Hexokinase when comparing incubation for 24 hours in media containing 0 and 20 µM CLT. Conclusion: This study and others indicate CLT as a possible radiosensitizing agent in cancer therapies. While CLT itself shows toxicity to the liver in high doses, this study further demonstrates that disruption of the Warburg Effect and unbinding of mitochondrial bound Hexokinase as a possible pathway for cancer treatment.« less

DRACO Flowpath Performance and Environments

NASA Technical Reports Server (NTRS)

Komar, D. R.; McDonald, Jon

1999-01-01

The Advanced Space Transportation (AST) project office has challenged NASA to design, manufacture, ground-test and flight-test an axisymmetric, hydrocarbon-fueled, flight-weight, ejector-ramjet engine system testbed no later than 2005. To accomplish this, a multi-center NASA team has been assembled. The goal of this team, led by NASA-Marshall Space Flight Center (MSFC), is to develop propulsion technologies that demonstrate rocket and airbreathing combined-cycle operation (DRACO). Current technical activities include flowpath conceptual design, engine systems conceptual design, and feasibility studies investigating the integration and operation of the DRACO engine with a Lockheed D-21B drone. This paper focuses on the activities of the Flowpath Systems Product Development Team (PDT), led by NASA-Glenn Research Center (GRC) and supported by NASA-MSFC and TechLand Research, Inc. The objective of the Flowpath PDT at the start of the DRACO program was to establish a conceptual design of the flowpath aerodynamic lines, determine the preliminary performance, define the internal environments, and support the DRACO testbed concept feasibility studies. To accomplish these tasks, the PDT convened to establish a baseline flowpath concept. With the conceptual lines defined, cycle analysis tasks were planned and the flowpath performance and internal environments were defined. Additionally, sensitivity studies investigating the effects of inlet reference area, combustion performance, and combustor/nozzle materials selection were performed to support the Flowpath PDT design process. Results of these tasks are the emphasis of this paper and are intended to verify the feasibility of the DRACO flowpath and engine system as well as identify the primary technical challenges inherent in the flight-weight design of an advanced propulsion technology demonstration engine. Preliminary cycle performance decks were developed to support the testbed concept feasibility studies but are not discussed further in this paper.

Deep transcranial magnetic stimulation for the treatment of auditory hallucinations: a preliminary open-label study

PubMed Central

2011-01-01

Background Schizophrenia is a chronic and disabling disease that presents with delusions and hallucinations. Auditory hallucinations are usually expressed as voices speaking to or about the patient. Previous studies have examined the effect of repetitive transcranial magnetic stimulation (TMS) over the temporoparietal cortex on auditory hallucinations in schizophrenic patients. Our aim was to explore the potential effect of deep TMS, using the H coil over the same brain region on auditory hallucinations. Patients and methods Eight schizophrenic patients with refractory auditory hallucinations were recruited, mainly from Beer Ya'akov Mental Health Institution (Tel Aviv university, Israel) ambulatory clinics, as well as from other hospitals outpatient populations. Low-frequency deep TMS was applied for 10 min (600 pulses per session) to the left temporoparietal cortex for either 10 or 20 sessions. Deep TMS was applied using Brainsway's H1 coil apparatus. Patients were evaluated using the Auditory Hallucinations Rating Scale (AHRS) as well as the Scale for the Assessment of Positive Symptoms scores (SAPS), Clinical Global Impressions (CGI) scale, and the Scale for Assessment of Negative Symptoms (SANS). Results This preliminary study demonstrated a significant improvement in AHRS score (an average reduction of 31.7% ± 32.2%) and to a lesser extent improvement in SAPS results (an average reduction of 16.5% ± 20.3%). Conclusions In this study, we have demonstrated the potential of deep TMS treatment over the temporoparietal cortex as an add-on treatment for chronic auditory hallucinations in schizophrenic patients. Larger samples in a double-blind sham-controlled design are now being preformed to evaluate the effectiveness of deep TMS treatment for auditory hallucinations. Trial registration This trial is registered with clinicaltrials.gov (identifier: NCT00564096). PMID:21303566

Continuum generation in ultra high numerical aperture fiber with application to multiphoton microscopy

NASA Astrophysics Data System (ADS)

Sayler, Nicholas

Nonlinear microscopy benefits from broadband laser sources, enabling efficient excitation of an array of fluorophores, for example. This work demonstrates broadening of a narrow band input pulse (6 nm to 40 nm) centered at 1040 nm with excellent shot-to-shot stability. In a preliminary demonstration, multiphoton imaging with pulses from the fiber is performed. In particular second harmonic imaging of corn starch is performed.

Heath Monitoring of Thermal Protection Systems - Preliminary Measurements and Design Specifications

NASA Technical Reports Server (NTRS)

Scott, D. A.; Price, D. C.

2007-01-01

The work reported here is the first stage of a project that aims to develop a health monitoring system for Thermal Protection Systems (TPS) that enables a vehicle to safely re-enter the Earth's atmosphere. The TPS health monitoring system is to be integrated into an existing acoustic emissions-based Concept Demonstrator, developed by CSIRO, which has been previously demonstrated for evaluating impact damage of aerospace systems.

Individual acoustic variation in Belding's ground squirrel alarm chirps in the High Sierra Nevada

NASA Astrophysics Data System (ADS)

McCowan, Brenda; Hooper, Stacie L.

2002-03-01

The acoustic structure of calls within call types can vary as function of individual identity, sex, and social group membership and is important in kin and social group recognition. Belding's ground squirrels (Spermophilus beldingi) produce alarm chirps that function in predator avoidance but little is known about the acoustic variability of these alarm chirps. The purpose of this preliminary study was to analyze the acoustic structure of alarm chirps with respect to individual differences (e.g., signature information) from eight Belding's ground squirrels from four different lakes in the High Sierra Nevada. Results demonstrate that alarm chirps are individually distinctive, and that acoustic similarity among individuals may correspond to genetic similarity and thus dispersal patterns in this species. These data suggest, on a preliminary basis, that the acoustic structure of calls might be used as a bioacoustic tool for tracking individuals, dispersal, and other population dynamics in Belding's ground squirrels, and perhaps other vocal species.

A preliminary RCT of CBT-AD for adherence and depression among HIV-positive Latinos on the U.S.-Mexico border: the Nuevo Día study.

PubMed

Simoni, Jane M; Wiebe, John S; Sauceda, John A; Huh, David; Sanchez, Giselle; Longoria, Virginia; Andres Bedoya, C; Safren, Steven A

2013-10-01

We conducted a preliminary RCT among 40 HIV-positive Latinos of Mexican descent on the U.S.-Mexico border who indicated imperfect adherence and depressive symptomatology. Participants were randomly assigned to culturally adapted cognitive-behavioral therapy for adherence and depression with an alarmed pillbox or usual care. Outcomes were depressive symptoms (self-report and blind clinician ratings), adherence (self-report and electronic pillbox), and biological markers. The intervention, delivered in English and Spanish, proved feasible and acceptable. Generalized estimating equations in intent-to-treat analyses showed some effects of "moderate" to "large" size, with maintenance over time. For example, intervention (vs. control) participants demonstrated at post-intervention a greater drop in BDI scores (OR = -3.64, p = 0.05) and greater adherence according to the electronic pillbox (OR = 3.78, p = 0.03). Biological markers indicated some relative improvement for CD4 count but not VL. The promising results suggest a larger trial to determine efficacy is warranted.

Description and preliminary results of a 100 square meter rain gauge

NASA Astrophysics Data System (ADS)

Grimaldi, Salvatore; Petroselli, Andrea; Baldini, Luca; Gorgucci, Eugenio

2018-01-01

Rainfall is one of the most crucial processes in hydrology, and the direct and indirect rainfall measurement methods are constantly being updated and improved. The standard instrument used to measure rainfall rate and accumulation is the rain gauge, which provides direct observations. Though the small dimension of the orifice allows rain gauges to be installed anywhere, it also causes errors due to the splash and wind effects. To investigate the role of the orifice dimension, this study, for the first time, introduces and demonstrates an apparatus for observing rainfall called a giant-rain gauge that is characterised by a collecting surface of 100 m2. To discuss the new instrument and its technical details, a preliminary analysis of 26 rainfall events is provided. The results suggest that there are significant differences between the standard and proposed rain gauges. Specifically, major discrepancies are evident for low time aggregation scale (5, 10, and 15 min) and for high rainfall intensity values.

Facile and Promising Method for Michael Addition of Indole and Pyrrole to Electron-Deficient trans-β-Nitroolefins Catalyzed by a Hydrogen Bond Donor Catalyst Feist's Acid and Preliminary Study of Antimicrobial Activity

PubMed Central

Al Majid, Abdullah M. A.; Islam, Mohammad Shahidul; Barakat, Assem; Al-Agamy, Mohamed H. M.; Naushad, Mu.

2014-01-01

The importance of cooperative hydrogen-bonding effects has been demonstrated using novel 3-methylenecyclopropane-1,2-dicarboxylic acid (Feist's acid (FA)) as hydrogen bond donor catalysts for the addition of indole and pyrrole to trans-β-nitrostyrene derivatives. Because of the hydrogen bond donor (HBD) ability, Feist's acid (FA) has been introduced as a new class of hydrogen bond donor catalysts for the activation of nitroolefin towards nucleophilic substitution reaction. It has effectively catalyzed the Michael addition of indoles and pyrrole to β-nitroolefins under optimum reaction condition to furnish the corresponding Michael adducts in good to excellent yields (up to 98%). The method is general, atom-economical, convenient, and eco-friendly and could provide excellent yields and regioselectivities. Some newly synthesized compounds were for examined in vitro antimicrobial activity and their preliminary results are reported. PMID:24574906

Sjögren's syndrome. Cutaneous, immunologic, and nervous system manifestations.

PubMed

Provost, T T; Vasily, D; Alexander, E

1987-08-01

The studies recounted in this review have demonstrated that cutaneous vasculitis is a frequent extraglandular manifestation of primary Sjögren's syndrome. Two histopathologic types of vasculitis have been detected. One type, a leukocytoclastic angiitis, is found in association with high-titer anti-Ro(SS-A) antibodies, rheumatoid factor, hypergammaglobulinemia, and hypocomplementemia. The second type, a mononuclear inflammatory vasculopathy, in sharp contrast, is found in association with low-titer Ro(SS-A) antibodies, normocomplementemia, and absence of hypergammaglobulinemia and rheumatoid factor. Both types of vasculitis are found in association with peripheral nervous system and CNS disease. The peripheral nervous system and CNS disease involves the entire neuroaxis and preliminary data indicate that a vasculopathy is the cause of the peripheral nervous system and CNS disease. Evoked sensory response testing, CSF analysis, and MRI have proved to be very valuable techniques in investigating these patients with Sjögren's syndrome. Preliminary data suggest that high doses of prednisone or immunosuppressive agents are effective in treating these patients.

Examining the Feasibility, Tolerability, and Preliminary Efficacy of Repetitive Task-Specific Practice for People With Unilateral Spatial Neglect

PubMed Central

Lang, Catherine E.; Birkenmeier, Rebecca; Holm, Margo; Rubinstein, Elaine; Van Swearingen, Jessie; Skidmore, Elizabeth R.

2016-01-01

OBJECTIVE. We examined the feasibility, tolerability, and preliminary efficacy of repetitive task-specific practice for people with unilateral spatial neglect (USN). METHOD. People with USN ≥6 mo poststroke participated in a single-group, repeated-measures study. Attendance, total repetitions, and satisfaction indicated feasibility and pain indicated tolerability. Paired t tests and effect sizes were used to estimate changes in upper-extremity use (Motor Activity Log), function (Action Research Arm Test), and attention (Catherine Bergego Scale). RESULTS. Twenty participants attended 99.4% of sessions and completed a high number of repetitions. Participants reported high satisfaction and low pain, and they demonstrated small, significant improvements in upper-extremity use (before Bonferroni corrections; t = –2.1, p = .04, d = .30), function (t = –3.0, p < .01, d = .20), and attention (t = –3.4, p < .01, d = –.44). CONCLUSION. Repetitive task-specific practice is feasible and tolerable for people with USN. Improvements in upper-extremity use, function, and attention may be attainable. PMID:27294994

A preliminary analysis of the effects of coaching feedback on teacher implementation fidelity of first step to success.

PubMed

Rodriguez, Billie Jo; Loman, Sheldon L; Horner, Robert H

2009-01-01

First Step to Success (FSS) is a "manualized" intervention with documented effectiveness in reducing problem behaviors for young children at risk for school failure. This study is a preliminary analysis focusing on the role of performance feedback from FSS coaches on the fidelity with which teachers implemented FSS. Three typically developing students (2 kindergarten and 1 first grade) and their respective teachers served as participants. Student behavior and teacher implementation fidelity were assessed using a nonconcurrent multiple baseline design across student/teacher dyads, in which a no coaching baseline was followed by a performance feedback condition. The baseline phase showed modest levels of implementation fidelity and initial low levels of problem behavior followed by gradually increasing trends. A relation was demonstrated between coaching feedback and improved implementation fidelity. In addition, improved fidelity was associated with improvements in student problem behavior. Implications are drawn for clinical application of FSS and other "manualized" interventions.

Exploring the Multicultural Competence of Leadership Educators

ERIC Educational Resources Information Center

Wilson, Amy B.

2013-01-01

Research examining multicultural competence among higher education professionals responsible for leadership education demonstrated significant correlations with racial identity and multicultural education and experiences. The Multicultural Competence in Student Affairs-Preliminary 2 (MCSA-P2) scale was used to measure multicultural competence.…

Connecticut Transit (CTTRANSIT) Fuel Cell Transit Bus Preliminary Evaluation Results

DOT National Transportation Integrated Search

2008-10-16

This report describes operations at Connecticut Transit (CTTRANSIT) in Hartford for one prototype fuel cell bus and three new diesel buses operating from the same location. The report discusses the planned fuel cell bus demonstration and equipment us...

A demonstrator for an incoherent Doppler wind lidar receiver

NASA Astrophysics Data System (ADS)

Fabre, F.; Marini, A.; Sidler, Thomas C.; Morancais, Didier; Fongy, G.; Vidal, Ph.

2018-04-01

The knowledge of wind fields for a global terrestrial coverage and accurate altitude sampling is one of the main keys for improvement of meteorological predictions and general understanding of atmosphere behaviour. The best way to recover this information is remote sensing from space using low Earth orbit satellites. The measurement principle is to analyse the Doppler shift of the flux emitted by the space instrument and backscattered by the atmosphere. One of the most promising principle for Doppler shift measurement is the direct detection which does not need local oscillators. what significantly simplifies the design of such a space-borne receiver. ESA-ESTEC initiated at early 95' a programme called "lncoherent Doppler Wind Lidar (IDWL) technologies" for the study and bread-boarding phase. MMS won this contract proposing an original concept based on the use of a Fizeau high resolution interferometer working in the UV band. coupled with an intensified CCD. This concept is patented by MMS, as well as the special CCD timing sequence that will be depicted below. The programme begun by a study of the space-borne instrument in order to identify main constraints and define the receiver as could be for a flight model. A detailed performance model was established and parametric analysis allowed to optimise the concept in order to reach required performances. This study phase finally provided the definition of a bread-board for expected performances demonstration. Moreover, the Laser Signal Simulator (LSS) which is used to simulate the Lidar echo in term of amplitude as well as frequency modulation was defined at this step. The performances of this test support equipment are of main importance for the validation of the demonstrator design and performances. The second part of the study aimed at defining the derailed design of the demonstrator and associated test support equipment as well as initiating preliminary validation experiments on most critical technologies, like Fizeau interferometer which needs particularly high thermal stability and spectral resolution. At the end of this design phase. the test bench equipment begun to be manufactured and equipment test results preliminary assessed the study phase results. After integration, the correct operation and control of the overall test bench were assessed and performance tests were undertaken . The final conclusion of this programme aimed at up­dating the performance simulation software in order to refine expected performances for the future flight instrument.

Opto-acoustic image fusion technology for diagnostic breast imaging in a feasibility study

NASA Astrophysics Data System (ADS)

Zalev, Jason; Clingman, Bryan; Herzog, Don; Miller, Tom; Ulissey, Michael; Stavros, A. T.; Oraevsky, Alexander; Lavin, Philip; Kist, Kenneth; Dornbluth, N. C.; Otto, Pamela

2015-03-01

Functional opto-acoustic (OA) imaging was fused with gray-scale ultrasound acquired using a specialized duplex handheld probe. Feasibility Study findings indicated the potential to more accurately characterize breast masses for cancer than conventional diagnostic ultrasound (CDU). The Feasibility Study included OA imagery of 74 breast masses that were collected using the investigational Imagio® breast imaging system. Superior specificity and equal sensitivity to CDU was demonstrated, suggesting that OA fusion imaging may potentially obviate the need for negative biopsies without missing cancers in a certain percentage of breast masses. Preliminary results from a 100 subject Pilot Study are also discussed. A larger Pivotal Study (n=2,097 subjects) is underway to confirm the Feasibility Study and Pilot Study findings.

Preliminary design study for an atomospheric science facility

NASA Technical Reports Server (NTRS)

Hutchison, R.

1972-01-01

The activities and results of the Atmospheric Science Facility preliminary design study are reported. The objectives of the study were to define the scientific goals, to determine the range of experiment types, and to develop the preliminary instrument design requirements for a reusable, general purpose, optical research facility for investigating the earth's atmosphere from a space shuttle orbital vehicle.

Science Support Room Operations During Desert RATS 2009

NASA Technical Reports Server (NTRS)

Lofgren, G. E.; Horz, F.; Bell, M. S.; Cohen, B. A.; Eppler,D. B.; Evans, C. a.; Hodges, K. V.; Hynek, B. M.; Gruener, J. E.; Kring, D. A.;

Chloroquine, quinine, procaine, quinidine, tricyclic antidepressants, and methylxanthines as prostaglandin agonists and antagonists.

PubMed

Manku, M S; Horrobin, D F

1976-11-20

Chloroquine, quanine, procaine, quinidine, clomipramine, theophylline, and caffeine have been shown to be strong prostaglandin antagonists and weak agonists. The antagonist effect is clearly demonstrable at concentrations reached in human plasma when the drugs are used therapeutically. This suggests that prostaglandins are important in several situations in which their role has hitherto been unsuspected. New approaches to the development of prostaglandin antagonists and new uses for established drugs are indicated. In a preliminary study chloroquine has been successfully used to close patent ductus arteriosus in three infants.

Voltage- and temperature- controlled LC:PDMS waveguide channels

NASA Astrophysics Data System (ADS)

Rutkowska, Katarzyna A.; Asquini, Rita; d'Alessandro, Antonio

2017-08-01

In this paper, we present our studies on electrical and thermal tuning of light propagation in waveguide channels, made for the scope from a polydimethylsiloxane (PDMS) substrate infiltrated with nematic liquid crystal (LC). We demonstrated, via numerical simulations, the changes of the waveguide optical parameters when solicited by temperature changes or electric fields. Moreover, the paper goes through the fabrication process of a waveguide channel sample and its characterization, as well as some preliminary experimental trials of sputtering indium tin oxide (ITO) and chromium layers on PDMS substrate to obtain flat electrodes.

Optical System Design for the Next Generation Space Telescope

NASA Technical Reports Server (NTRS)

Solomon, Leonard H. (Principal Investigator); Kahan, Mark A.

1996-01-01

This report provides considerations and suggested approaches for design of the Optical Telescope Assembly and the segmented primary mirror of a Next Generation Space Telescope (NGST). Based on prior studies and hardware development, we provide data and design information on low-risk materials and hardware configurations most likely to meet low weight, low temperature and long-life requirements of the nominal 8-meter aperture NGST. We also provide preliminary data for cost and performance trades, and recommendations for technology development and demonstration required to support the system design effort.

Some aspects of wind tunnel magnetic suspension systems with special application at large physical scales

NASA Technical Reports Server (NTRS)

Britcher, C. P.

1983-01-01

Wind tunnel magnetic suspension and balance systems (MSBSs) have so far failed to find application at the large physical scales necessary for the majority of aerodynamic testing. Three areas of technology relevant to such application are investigated. Two variants of the Spanwise Magnet roll torque generation scheme are studied. Spanwise Permanent Magnets are shown to be practical and are experimentally demonstrated. Extensive computations of the performance of the Spanwise Iron Magnet scheme indicate powerful capability, limited principally be electromagnet technology. Aerodynamic testing at extreme attitudes is shown to be practical in relatively conventional MSBSs. Preliminary operation of the MSBS over a wide range of angles of attack is demonstrated. The impact of a requirement for highly reliable operation on the overall architecture of Large MSBSs is studied and it is concluded that system cost and complexity need not be seriously increased.

Pinosylvin-Based Polymers: Biodegradable Poly(Anhydride-Esters) for Extended Release of Antibacterial Pinosylvin.

PubMed

Bien-Aime, Stephan; Yu, Weiling; Uhrich, Kathryn E

2016-07-01

Pinosylvin is a natural stilbenoid known to exhibit antibacterial bioactivity against foodborne bacteria. In this work, pinosylvin is chemically incorporated into a poly(anhydride-ester) (PAE) backbone via melt-condensation polymerization, and characterized with respect to its physicochemical and thermal properties. In vitro release studies demonstrate that pinosylvin-based PAEs hydrolytically degrade over 40 d to release pinosylvin. Pseudo-first order kinetic experiments on model compounds, butyric anhydride and 3-butylstilbene ester, indicate that the anhydride linkages hydrolyze first, followed by the ester bonds to ultimately release pinosylvin. An antibacterial assay shows that the released pinosylvin exhibit bioactivity, while in vitro cytocompatibility studies demonstrate that the polymer is noncytotoxic toward fibroblasts. These preliminary findings suggest that the pinosylvin-based PAEs can serve as food preservatives in food packaging materials by safely providing antibacterial bioactivity over extended time periods. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Toward continuous glucose monitoring with planar modified biosensors and microdialysis. Study of temperature, oxygen dependence and in vivo experiment.

PubMed

Ricci, Francesco; Caprio, Felice; Poscia, Alessandro; Valgimigli, Francesco; Messeri, Dimitri; Lepori, Elena; Dall'Oglio, Giorgio; Palleschi, Giuseppe; Moscone, Danila

2007-04-15

Glucose biosensors based on the use of planar screen-printed electrodes modified with an electrochemical mediator and with glucose oxidase have been optimised for their application in the continuous glucose monitoring in diabetic patients. A full study of their operative stability and temperature dependence has been accomplished, thus giving useful information for in vivo applications. The effect of dissolved oxygen concentration in the working solution was also studied in order to evaluate its effect on the linearity of the sensors. Glucose monitoring performed with serum samples was performed to evaluate the effect of matrix components on operative stability and demonstrated an efficient behaviour for 72 h of continuous monitoring. Finally, these studies led to a sensor capable of detecting glucose at concentrations as low as 0.04 mM and with a good linearity up to 2.0 mM (at 37 degrees C) with an operative stability of ca. 72 h, thus demonstrating the possible application of these sensors for continuous glucose monitoring in conjunction with a microdialysis probe. Moreover, preliminary in vivo experiments for ca. 20 h have demonstrated the feasibility of this system.

Measuring the impact and distress of health problems from the individual's perspective: development of the Perceived Impact of Problem Profile (PIPP)

PubMed Central

Pallant, Julie F; Misajon, RoseAnne; Bennett, Elizabeth; Manderson, Lenore

2006-01-01

Background The aim of this study was to develop and conduct preliminary validation of the Perceived Impact of Problem Profile (PIPP). Based on the biopsychosocial model of health and functioning, the PIPP was intended as a generic research and clinical measurement tool to assess the impact and distress of health conditions from the individuals' perspective. The ICF classification system was used to guide the structure of the PIPP with subscales included to assess impact on self-care, mobility, participation, relationships and psychological well-being. While the ICF focuses on the classification of objective health and health related status, the PIPP broadens this focus to address the individuals' subjective experience of their health condition. Methods An item pool of 23 items assessing both impact and distress on five key domains was generated. These were administered to 169 adults with mobility impairment. Rasch analysis using RUMM2020 was conducted to assess the psychometric properties of each set of items. Preliminary construct validation of the PIPP was performed using the EQ5D. Results For both the Impact and Distress scales of the PIPP, the five subscales (Self-care, Mobility, Participation, Relationships, and Psychological Well-being) showed adequate psychometric properties, demonstrating fit to the Rasch model. All subscales showed adequate person separation reliability and no evidence of differential item functioning for sex, age, educational level or rural vs urban residence. Preliminary validity testing using the EQ5D items provided support for the subscales. Conclusion This preliminary study, using a sample of adults with mobility impairment, provides support for the psychometric properties of the PIPP as a potential clinical and research measurement tool. The PIPP provides a brief, but comprehensive means to assess the key ICF components, focusing on the individuals' perspective of the impact and distress caused by their health condition. Further validation of its use across different health conditions and varying cultural settings is required. PMID:16808842

Ayahuasca-assisted therapy for addiction: results from a preliminary observational study in Canada.

PubMed

Thomas, Gerald; Lucas, Philippe; Capler, N Rielle; Tupper, Kenneth W; Martin, Gina

2013-03-01

This paper reports results from a preliminary observational study of ayahuasca-assisted treatment for problematic substance use and stress delivered in a rural First Nations community in British Columbia, Canada. The "Working with Addiction and Stress" retreats combined four days of group counselling with two expert-led ayahuasca ceremonies. This study collected pre-treatment and six months follow-up data from 12 participants on several psychological and behavioral factors related to problematic substance use, and qualitative data assessing the personal experiences of the participants six months after the retreat. Statistically significant (p < 0.05) improvements were demonstrated for scales assessing hopefulness, empowerment, mindfulness, and quality of life meaning and outlook subscales. Self-reported alcohol, tobacco and cocaine use declined, although cannabis and opiate use did not; reported reductions in problematic cocaine use were statistically significant. All study participants reported positive and lasting changes from participating in the retreats. This form of ayahuasca-assisted therapy appears to be associated with statistically significant improvements in several factors related to problematic substance use among a rural aboriginal population. These findings suggest participants may have experienced positive psychological and behavioral changes in response to this therapeutic approach, and that more rigorous research of ayahuasca-assisted therapy for problematic substance use is warranted.

A preliminary study of muscular artifact cancellation in single-channel EEG.

PubMed

Chen, Xun; Liu, Aiping; Peng, Hu; Ward, Rabab K

2014-10-01

Electroencephalogram (EEG) recordings are often contaminated with muscular artifacts that strongly obscure the EEG signals and complicates their analysis. For the conventional case, where the EEG recordings are obtained simultaneously over many EEG channels, there exists a considerable range of methods for removing muscular artifacts. In recent years, there has been an increasing trend to use EEG information in ambulatory healthcare and related physiological signal monitoring systems. For practical reasons, a single EEG channel system must be used in these situations. Unfortunately, there exist few studies for muscular artifact cancellation in single-channel EEG recordings. To address this issue, in this preliminary study, we propose a simple, yet effective, method to achieve the muscular artifact cancellation for the single-channel EEG case. This method is a combination of the ensemble empirical mode decomposition (EEMD) and the joint blind source separation (JBSS) techniques. We also conduct a study that compares and investigates all possible single-channel solutions and demonstrate the performance of these methods using numerical simulations and real-life applications. The proposed method is shown to significantly outperform all other methods. It can successfully remove muscular artifacts without altering the underlying EEG activity. It is thus a promising tool for use in ambulatory healthcare systems.

A preliminary study on the potential of manuka honey and platelet-rich plasma in wound healing.

PubMed

Sell, Scott A; Wolfe, Patricia S; Spence, Andrew J; Rodriguez, Isaac A; McCool, Jennifer M; Petrella, Rebecca L; Garg, Koyal; Ericksen, Jeffery J; Bowlin, Gary L

2012-01-01

Aim. The purpose of this study was to determine the in vitro response of cells critical to the wound healing process in culture media supplemented with a lyophilized preparation rich in growth factors (PRGF) and Manuka honey. Materials and Methods. This study utilized cell culture media supplemented with PRGF, as well as whole Manuka honey and the medical-grade Medihoney (MH), a Manuka honey product. The response of human fibroblasts (hDF), macrophages, and endothelial cells (hPMEC) was evaluated, with respect to cell proliferation, chemotaxis, collagen matrix production, and angiogenic potential, when subjected to culture with media containing PRGF, MH, Manuka honey, and a combination of PRGF and MH. Results. All three cell types demonstrated increases in cellular activity in the presence of PRGF, with further increases in activity seen in the presence of PRGF+MH. hDFs proved to be the most positively responsive cells, as they experienced enhanced proliferation, collagen matrix production, and migration into an in vitro wound healing model with the PRGF+MH-supplemented media. Conclusion. This preliminary in vitro study is the first to evaluate the combination of PRGF and Manuka honey, two products with the potential to increase regeneration individually, as a combined product to enhance dermal regeneration.

A Preliminary Study on the Potential of Manuka Honey and Platelet-Rich Plasma in Wound Healing

PubMed Central

Sell, Scott A.; Wolfe, Patricia S.; Spence, Andrew J.; Rodriguez, Isaac A.; McCool, Jennifer M.; Petrella, Rebecca L.; Garg, Koyal; Ericksen, Jeffery J.; Bowlin, Gary L.

2012-01-01

Aim. The purpose of this study was to determine the in vitro response of cells critical to the wound healing process in culture media supplemented with a lyophilized preparation rich in growth factors (PRGF) and Manuka honey. Materials and Methods. This study utilized cell culture media supplemented with PRGF, as well as whole Manuka honey and the medical-grade Medihoney (MH), a Manuka honey product. The response of human fibroblasts (hDF), macrophages, and endothelial cells (hPMEC) was evaluated, with respect to cell proliferation, chemotaxis, collagen matrix production, and angiogenic potential, when subjected to culture with media containing PRGF, MH, Manuka honey, and a combination of PRGF and MH. Results. All three cell types demonstrated increases in cellular activity in the presence of PRGF, with further increases in activity seen in the presence of PRGF+MH. hDFs proved to be the most positively responsive cells, as they experienced enhanced proliferation, collagen matrix production, and migration into an in vitro wound healing model with the PRGF+MH-supplemented media. Conclusion. This preliminary in vitro study is the first to evaluate the combination of PRGF and Manuka honey, two products with the potential to increase regeneration individually, as a combined product to enhance dermal regeneration. PMID:23304152

Prototype next generation frog foundation - preliminary evaluation : research results.

DOT National Transportation Integrated Search

2016-06-01

Conventional wisdom suggests that a solid or rigid one-piece frog is preferred because it is easy to maintain. However, testing and subsequent modeling demonstrated that a flexible frog (i.e., a two-piece frog split in the flangeway) produced signifi...

Thermal Gradient Fining of Glass

NASA Technical Reports Server (NTRS)

Wilcox, W.

1983-01-01

Molten glass fined (cleared of bubbles) by heating with suitable temperature gradient, according to preliminary experiments. Temperature gradient produces force on gas bubbles trapped in molten glass pushing bubbles to higher temperature region where they are collected. Concept demonstrated in experiments on Earth and on rocket.

A Preliminary Assessment of Silver Nanoparticle Inhibition of Monkeypox Virus Plaque Formation

NASA Astrophysics Data System (ADS)

Rogers, James V.; Parkinson, Christopher V.; Choi, Young W.; Speshock, Janice L.; Hussain, Saber M.

2008-04-01

The use of nanotechnology and nanomaterials in medical research is growing. Silver-containing nanoparticles have previously demonstrated antimicrobial efficacy against bacteria and viral particles. This preliminary study utilized an in vitro approach to evaluate the ability of silver-based nanoparticles to inhibit infectivity of the biological select agent, monkeypox virus (MPV). Nanoparticles (10 80 nm, with or without polysaccharide coating), or silver nitrate (AgNO3) at concentrations of 100, 50, 25, and 12.5 μg/mL were evaluated for efficacy using a plaque reduction assay. Both Ag-PS-25 (polysaccharide-coated, 25 nm) and Ag-NP-55 (non-coated, 55 nm) exhibited a significant ( P ≤ 0.05) dose-dependent effect of test compound concentration on the mean number of plaque-forming units (PFU). All concentrations of silver nitrate (except 100 μg/mL) and Ag-PS-10 promoted significant ( P ≤ 0.05) decreases in the number of observed PFU compared to untreated controls. Some nanoparticle treatments led to increased MPV PFU ranging from 1.04- to 1.8-fold above controls. No cytotoxicity (Vero cell monolayer sloughing) was caused by any test compound, except 100 μg/mL AgNO3. These results demonstrate that silver-based nanoparticles of approximately 10 nm inhibit MPV infection in vitro, supporting their potential use as an anti-viral therapeutic.

Preliminary technology utilization assessment of the robotic fruit harvester

NASA Technical Reports Server (NTRS)

Wilhelm, J.

1982-01-01

The results of an analysis whose purpose was to examine the history and progress of mechanical fruit harvesting, to determine the significance of a robotic fruit tree harvester and to assess the available market for such a product are summarized. Background information that can be used in determining the benefit of a proof of principle demonstration is provided. Such a demonstration could be a major step toward the transfer of this NASA technology.

A Study of an Optical Lunar Surface Communications Network with High Bandwidth Direct to Earth Link

NASA Technical Reports Server (NTRS)

Wilson, K.; Biswas, A.; Schoolcraft, J.

2011-01-01

Analyzed optical DTE (direct to earth) and lunar relay satellite link analyses, greater than 200 Mbps downlink to 1-m Earth receiver and greater than 1 Mbps uplink achieved with mobile 5-cm lunar transceiver, greater than 1Gbps downlink and greater than 10 Mpbs uplink achieved with 10-cm stationary lunar transceiver, MITLL (MIT Lincoln Laboratory) 2013 LLCD (Lunar Laser Communications Demonstration) plans to demonstrate 622 Mbps downlink with 20 Mbps uplink between lunar orbiter and ground station; Identified top five technology challenges to deploying lunar optical network, Performed preliminary experiments on two of challenges: (i) lunar dust removal and (ii)DTN over optical carrier, Exploring opportunities to evaluate DTN (delay-tolerant networking) over optical link in a multi-node network e.g. Desert RATS.

Lessons Learned from Inlet Integration Analysis of NASA's Low Boom Flight Demonstrator

NASA Technical Reports Server (NTRS)

Friedlander, David; Heath, Christopher; Castner, Ray

2017-01-01

In 2016, NASA's Aeronautics Research Mission Directorate announced the New Aviation Horizons Initiative with a goal of designing/building several X-Planes, including a Low Boom Flight Demonstrator (LBFD). That same year, NASA awarded a contract to Lockheed Martin (LM) to advance the LBFD concept through preliminary design. Several configurations of the LBFD aircraft were analyzed by both LM engineers and NASA researchers. This presentation focuses on some of the CFD simulations that were run by NASA Glenn researchers. NASA's FUN3D V13.1 code was used for all adjoint-based grid refinement studies and Spalart-Allmaras turbulence model was used during adaptation. It was found that adjoint-based grid adaptation did not accurately capture inlet performance for high speed top-aft-mounted propulsion.

Ar-Ar Thermochronlogy of Apollo 12 Impact-Melt Breccia 12033,638-1

NASA Technical Reports Server (NTRS)

Crow, C. A.; Cassata, W. S.; Jolliff, B. L.; Ziegler, R. A.; Borg, L. E.; Shearer, C. K.

2017-01-01

We have undertaken an Ar-Ar thermochronology investigation as part of a coordinated multichronometer analysis of a single Apollo 12 impact- melt breccia to demonstrate the wide range of information that can be obtained for a single complex rock. This has implications for the age of formation, component makeup, and subsequent impact/shock and exposure history of the sample. This study also serves as a capabilities demonstration for the proposed MoonRise Mission [1]. The goal of this investigation is to elucidate the history of this sample through coordinated 40Ar*/39Ar, Sm-Nd, Rb-Sr and zircon 207Pb-206Pb ages along with geochemical and petrographic context on a relatively small (approximately 450 mg) sample. Here, we report preliminary results of the Ar-Ar thermochronology.

Design, synthesis and biological activity of 6-substituted carbamoyl benzimidazoles as new nonpeptidic angiotensin II AT₁ receptor antagonists.

PubMed

Zhang, Jun; Wang, Jin-Liang; Zhou, Zhi-Ming; Li, Zhi-Huai; Xue, Wei-Zhe; Xu, Di; Hao, Li-Ping; Han, Xiao-Feng; Fei, Fan; Liu, Ting; Liang, Ai-Hua

2012-07-15

A series of 6-substituted carbamoyl benzimidazoles were designed and synthesised as new nonpeptidic angiotensin II AT(1) receptor antagonists. The preliminary pharmacological evaluation revealed a nanomolar AT(1) receptor binding affinity for all compounds in the series, and a potent antagonistic activity in an isolated rabbit aortic strip functional assay for compounds 6f, 6g, 6h and 6k was also demonstrated. Furthermore, evaluation in spontaneous hypertensive rats and a preliminary toxicity evaluation showed that compound 6g is an orally active AT(1) receptor antagonist with low toxicity. Copyright © 2012 Elsevier Ltd. All rights reserved.

Airborne oceanographic lidar system

NASA Technical Reports Server (NTRS)

1975-01-01

Specifications and preliminary design of an Airborne Oceanographic Lidar (AOL) system, which is to be constructed for installation and used on a NASA Wallops Flight Center (WFC) C-54 research aircraft, are reported. The AOL system is to provide an airborne facility for use by various government agencies to demonstrate the utility and practicality of hardware of this type in the wide area collection of oceanographic data on an operational basis. System measurement and performance requirements are presented, followed by a description of the conceptual system approach and the considerations attendant to its development. System performance calculations are addressed, and the system specifications and preliminary design are presented and discussed.

Trajectory-Oriented Approach to Managing Traffic Complexity: Trajectory Flexibility Metrics and Algorithms and Preliminary Complexity Impact Assessment

NASA Technical Reports Server (NTRS)

Idris, Husni; Vivona, Robert A.; Al-Wakil, Tarek

2009-01-01

This document describes exploratory research on a distributed, trajectory oriented approach for traffic complexity management. The approach is to manage traffic complexity based on preserving trajectory flexibility and minimizing constraints. In particular, the document presents metrics for trajectory flexibility; a method for estimating these metrics based on discrete time and degree of freedom assumptions; a planning algorithm using these metrics to preserve flexibility; and preliminary experiments testing the impact of preserving trajectory flexibility on traffic complexity. The document also describes an early demonstration capability of the trajectory flexibility preservation function in the NASA Autonomous Operations Planner (AOP) platform.

Small, high pressure ratio compressor: Aerodynamic and mechanical design

NASA Technical Reports Server (NTRS)

Bryce, C. A.; Erwin, J. R.; Perrone, G. L.; Nelson, E. L.; Tu, R. K.; Bosco, A.

1973-01-01

The Small, High-Pressure-Ratio Compressor Program was directed toward the analysis, design, and fabrication of a centrifugal compressor providing a 6:1 pressure ratio and an airflow rate of 2.0 pounds per second. The program consists of preliminary design, detailed areodynamic design, mechanical design, and mechanical acceptance tests. The preliminary design evaluate radial- and backward-curved blades, tandem bladed impellers, impeller-and diffuser-passage boundary-layer control, and vane, pipe, and multiple-stage diffusers. Based on this evaluation, a configuration was selected for detailed aerodynamic and mechanical design. Mechanical acceptance test was performed to demonstrate that mechanical design objectives of the research package were met.

Trapping para-Quinone Methide Intermediates with Ferrocene: Synthesis and Preliminary Biological Evaluation of New Phenol-Ferrocene Conjugates.

PubMed

González-Pelayo, Silvia; López, Enol; Borge, Javier; de-Los-Santos-Álvarez, Noemí; López, Luis A

2018-06-01

The reaction of para -hydroxybenzyl alcohols with ferrocene in the presence of a catalytic amount of InCl₃ provided ferrocenyl phenol derivatives, an interesting class of organometallic compounds with potential applications in medicinal chemistry. This transformation exhibited a reasonable substrate scope delivering the desired products in synthetically useful yields. Evidence of involvement of a para -quinone methide intermediate in this coupling process was also provided. Preliminary biological evaluation demonstrated that some of the ferrocene derivatives available by this methodology exhibit significant cytotoxicity against several cancer cell lines with IC 50 values within the range of 1.07⁻4.89 μM.

Preliminary Field Demonstration of Passive Radio Sounding Using the Sun as a Signal for Echo Detection

NASA Astrophysics Data System (ADS)

Peters, S. T.; Schroeder, D. M.; Romero-Wolf, A.; Haynes, M.

2017-12-01

The Radar for Icy Moon Exploration (RIME) and the Radar for Europa Assessment and Sounding: Ocean to Near-surface (REASON) have been identified as potential candidates for the implementation of passive sounding as additional observing modes for the ESA and NASA missions to Ganymede and Europa. Recent work has shown the theoretical potential for Jupiter's decametric radiation to be used as a source for passive radio sounding of its icy moons. We are further developing and adapting this geophysical approach for use in terrestrial glaciology. Here, we present results from preliminary field testing of a prototype passive radio sounder from cliffs along the California coast. This includes both using a Lloyd's mirror to measure the Sun's direct path and its reflection off the ocean's surface and exploiting autocorrelation to detect the delay time of the echo. This is the first in-situ demonstration of the autocorrelation-based passive-sounding approach using an astronomical white noise signal. We also discuss preliminary field tests on rougher terrestrial and subglacial surfaces, including at Store Glacier in Greenland. Additionally, we present modeling and experimental results that demonstrate the feasibility of applying presumming approaches to the autocorrelations to achieve coherent gain from an inherently random signal. We note that while recording with wider bandwidths and greater delays places fundamental limits on the Lloyd's mirror approach, our new autocorrelation method has no such limitation. Furthermore, we show how achieving wide bandwidths via spectral-stitching methods allows us to obtain a finer range resolution than given by the receiver's instantaneous bandwidth. Finally, we discuss the potential for this technique to eliminate the need for active transmitters in certain types of ice sounding experiments, thereby reducing the complexity, power consumption, and cost of systems and observations.

Design Study of 8 Meter Monolithic Mirror UV/Optical Space Telescope

NASA Technical Reports Server (NTRS)

Stahl, H. Philip

2008-01-01

The planned Ares V launch vehicle with its 10 meter fairing shroud and 55,000 kg capacity to the Sun Earth L2 point enables entirely new classes of space telescopes. NASA MSFC has conducted a preliminary study that demonstrates the feasibility of launching a 6 to 8 meter class monolithic primary mirror telescope to Sun-Earth L2 using an Ares V. Specific technical areas studied included optical design; structural design/analysis including primary mirror support structure, sun shade and secondary mirror support structure; thermal analysis; launch vehicle performance and trajectory; spacecraft including structure, propulsion, GN&C, avionics, power systems and reaction wheels; operations and servicing; mass and power budgets; and system cost.

Kinetics and pathogenesis of intracellular magnetic nanoparticle cytotoxicity

NASA Astrophysics Data System (ADS)

Giustini, Andrew J.; Gottesman, Rachel E.; Petryk, A. A.; Rauwerdink, A. M.; Hoopes, P. Jack

2011-03-01

Magnetic nanoparticles excited by alternating magnetic fields (AMF) have demonstrated effective tumor-specific hyperthermia. This treatment is effective as a monotherapy as well as a therapeutic adjuvant to chemotherapy and radiation. Iron oxide nanoparticles have been shown, so far, to be non-toxic, as are the exciting AMF fields when used at moderate levels. Although higher levels of AMF can be more effective, depending on the type of iron oxide nanoparticles use, these higher field strengths and/or frequencies can induce normal tissue heating and toxicity. Thus, the use of nanoparticles exhibiting significant heating at low AMF strengths and frequencies is desirable. Our preliminary experiments have shown that the aggregation of magnetic nanoparticles within tumor cells improves their heating effect and cytotoxicity per nanoparticle. We have used transmission electron microscopy to track the endocytosis of nanoparticles into tumor cells (both breast adenocarcinoma (MTG-B) and acute monocytic leukemia (THP-1) cells). Our preliminary results suggest that nanoparticles internalized into tumor cells demonstrate greater cytotoxicity when excited with AMF than an equivalent heat dose from excited external nanoparticles or cells exposed to a hot water bath. We have also demonstrated that this increase in SAR caused by aggregation improves the cytotoxicity of nanoparticle hyperthermia therapy in vitro.

Development and reliability of a preliminary Foot Osteoarthritis Magnetic Resonance Imaging Score

PubMed Central

Halstead, Jill; Martín-Hervás, Carmen; Hensor, Elizabeth MA; McGonagle, Dennis; Keenan, Anne-Maree

2017-01-01

Objective Foot osteoarthritis (OA) is very common but under-investigated musculoskeletal condition and there is little consensus as to common MRI imaging features. The aim of this study was to develop a preliminary foot OA MRI score (FOAMRIS) and evaluate its reliability. Methods This preliminary semi-quantitative score included the hindfoot, midfoot and metatarsophalangeal joints. Joints were scored for joint space narrowing (JSN, 0-3), osteophytes (0-3), joint effusion-synovitis and bone cysts (present/absent). Erosions and bone marrow lesions (BMLs) were scored (0-3) and BMLs were evaluated adjacent to entheses and at sub-tendon sites (present/absent). Additionally, tenosynovitis was scored (0-3) and midfoot ligament pathology was scored (present/absent). Reliability was evaluated in 15 people with foot pain and MRI-detected OA using 3.0T MRI multi-sequence protocols and assessed using intraclass correlation coefficients (ICC) as an overall score and per anatomical site (see supplementary data). Results Intra-reader agreement (ICC) was generally good to excellent across the foot in joint features (JSN 0.94, osteophytes 0.94, effusion-synovitis 0.62 and cysts 0.93), bone features (BML 0.89, erosion 0.78, BML-entheses 0.79, BML sub-tendon 0.75) and soft-tissue features (tenosynovitis 0.90, ligaments 0.87). Inter-reader agreement was lower for joint features (JSN 0.60, osteophytes 0.41, effusion-synovitis 0.03) and cysts 0.65, bone features (BML 0.80, erosion 0.00, BML-entheses 0.49, BML sub-tendon -0.24) and soft-tissue features (tenosynovitis 0.48, ligaments 0.50). Conclusion This preliminary FOAMRIS demonstrated good intra-reader reliability and fair inter-reader reliability when assessing the total feature scores. Further development is required in cohorts with a range of pathologies and to assess the psychometric measurement properties. PMID:28572462

A Reconnaissance Study as a "Sine Qua Non Factor" for Status Quo Change among Senior Phase Technology Teachers

ERIC Educational Resources Information Center

Mapotse, Tomé Awshar

2015-01-01

This article is based on a preliminary action research (AR) study conducted with selected schools in Limpopo. It intends to report on the progress made and research problem identified during the reconnaissance/preliminary study. The aim of this preliminary research is to ascertain whether the findings conform to the main research question of the…

9-1529 : low-cost safety solutions, pavement preservation, and maintenance practices for rural highways.

DOT National Transportation Integrated Search

2014-08-01

Task 1 : The objective of this project was to develop and : demonstrate innovative low-cost solutions to : improve safety at stop-controlled intersections. : Preliminary directives from the project panel : were to focus on treatments on the minor str...

Preliminary Evaluation of a Diagnostic Tool for Prosthetics

DTIC Science & Technology

2017-10-01

volume change. Processing algorithms for data from the activity monitors were modified to run more efficiently so that large datasets could be...left) and blade style prostheses (right). Figure 4: Ankle ActiGraph correct position demonstrated for a left leg below-knee amputee cylindrical

Remote sensing of turbidity plumes in Lake Ontario

NASA Technical Reports Server (NTRS)

Pluhowski, E. J.

1973-01-01

Preliminary analyses of ERTS-1 imagery demonstrates the utility of the satellite to monitor turbidity plumes generated by the Welland Canal, and the Genese and Oswego Rivers. Although visible in high altitude photographs, the Niagara River plume is not readily identifiable from satellite imagery.

An initial validation of the Virtual Reality Paced Auditory Serial Addition Test in a college sample.

PubMed

Parsons, Thomas D; Courtney, Christopher G

2014-01-30

Numerous studies have demonstrated that the Paced Auditory Serial Addition Test (PASAT) has utility for the detection of cognitive processing deficits. While the PASAT has demonstrated high levels of internal consistency and test-retest reliability, administration of the PASAT has been known to create undue anxiety and frustration in participants. As a result, degradation of performance may be found on the PASAT. The difficult nature of the PASAT may subsequently decrease the probability of their return for follow up testing. This study is a preliminary attempt at assessing the potential of a PASAT embedded in a virtual reality environment. The Virtual Reality PASAT (VR-PASAT) was compared with a paper-and-pencil version of the PASAT as well as other standardized neuropsychological measures. The two modalities of the PASAT were conducted with a sample of 50 healthy university students, between the ages of 19 and 34 years. Equivalent distributions were found for age, gender, education, and computer familiarity. Moderate relationships were found between VR-PASAT and other putative attentional processing measures. The VR-PASAT was unrelated to indices of learning, memory, or visuospatial processing. Comparison of the VR-PASAT with the traditional paper-and-pencil PASAT indicated that both versions require the examinee to sustain attention at an increasingly demanding, externally determined rate. Results offer preliminary support for the construct validity (in a college sample) of the VR-PASAT as an attentional processing measure and suggest that this task may provide some unique information not tapped by traditional attentional processing tasks. Copyright © 2013 Elsevier B.V. All rights reserved.

Making and Executing Decisions for Safe and Independent Living (MED-SAIL): Development and Validation of a Brief Screening Tool

PubMed Central

Mills, Whitney L.; Regev, Tziona; Kunik, Mark E.; Wilson, Nancy L.; Moye, Jennifer; McCullough, Laurence B.; Naik, Aanand D.

2017-01-01

Objectives Older adults prefer to remain in their own homes for as long as possible. The purpose of this article is to describe the development and preliminary validation of Making and Executing Decisions for Safe and Independent Living (MED-SAIL), a brief screening tool for capacity to live safely and independently in the community. Design Prospective preliminary validation study. Setting Outpatient geriatrics clinic located in a community-based hospital. Participants Forty-nine community-dwelling older adults referred to the clinic for a comprehensive capacity assessment. Measurements We examined internal consistency, criterion-based validity, concurrent validity, and accuracy of classification for MED-SAIL. Results The items included in MED-SAIL demonstrated internal consistency (5 items; α = 0.85). MED-SAIL was significantly correlated with the Independent Living Scales (r = 0.573, p ≤ 0.001) and instrumental activities of daily living (r = 0.440, p ≤ 0.01). The Mann-Whitney U test revealed significant differences between the no capacity and partial/full capacity classifications on MED-SAIL (U(48) = 60.5, Z = −0.38, p <0.0001). The area under the curve was 0.864 (95% confidence interval: 0.84–0.99). Conclusions This study demonstrated the validity of MED-SAIL as a brief screening tool to identify older adults with impaired capacity for remaining safe and independent in their current living environment. MED-SAIL is useful tool for health and social service providers in the community for the purpose of referral for definitive capacity evaluation. PMID:23567420

Asians demonstrate reduced sensitivity to unpredictable threat: a preliminary startle investigation using genetic ancestry in a multiethnic sample.

PubMed

Nelson, Brady D; Bishop, Jeffrey R; Sarapas, Casey; Kittles, Rick A; Shankman, Stewart A

2014-06-01

Research has indicated that individuals of Asian descent, relative to other racial groups, demonstrate reduced emotional responding and lower prevalence rates of several anxiety disorders. It is unclear though whether these group differences extend to biomarkers of anxiety disorders and whether genetic differences play a role. This study compared self-identified Caucasian, Latino, and Asian persons (total N = 174) on startle response during a baseline period and while anticipating unpredictable threat-a putative biomarker for certain anxiety disorders--as well as predictable threat. In addition, the association between genetic ancestry and startle response was examined within each racial group to determine potential genetic influences on responding. For the baseline period, Asian participants exhibited a smaller startle response relative to Caucasian and Latino participants, who did not differ. Within each racial group, genetic ancestry was associated with baseline startle. Furthermore, genetic ancestry mediated racial group differences in baseline startle. For the threat conditions, a Race × Condition interaction indicated that Asian participants exhibited reduced startle potentiation to unpredictable, but not predicable, threat relative to Caucasian and Latino participants, who did not differ. However, genetic ancestry was not associated with threat-potentiated startle in any racial group. This study adds to the growing literature on racial differences in emotional responding and provides preliminary evidence suggesting that genetic ancestry may play an important role. Moreover, reduced sensitivity to unpredictable threat may reflect a mechanism for why individuals of Asian descent are at less risk for particular anxiety disorders relative to other racial groups.

Use of EOS Low-Dose Biplanar X-Ray for Shunt Series in Children with Hydrocephalus: A Preliminary Study.

PubMed

Ben-Sira, Liat; Shiran, Shelly I; Pratt, Li-Tal; Precel, Ronit; Ovadia, Dror; Constantini, Shlomi; Roth, Jonathan

2018-05-04

Shunt series (SS) are a common diagnostic tool used to verify shunt integrity. SS include X-ray films of the skull, chest, and abdomen and often are performed either when a shunted patient presents with suspected shunt malfunction or as a screening test to identify shunt disconnections or dislodgment. EOS low-dose biplanar X-rays are associated with significantly reduced radiation doses compared with ordinary X-rays and are used for various indications. This is the first publication on the use of EOS as a SS technique. Over a period of 6 months, EOS were performed at our center for various orthopedic indications, mostly for scoliosis evaluation. Nine children (<20 years of age) had a ventriculoperitoneal shunt and served as the study group. We retrospectively reviewed shunt visibility and integrity in the EOS scans as well as regular SS or plain spinal X-rays. Three patients had bilateral shunts, and 8 had previous X-rays for comparison. In all patients, the shunt integrity was easily demonstrated on the EOS images. Two patients had an identified shunt disconnection confirmed on the EOS images. No shunt-related information was missed on the EOS compared with the other X-ray images. These preliminary results suggest that EOS may be used as an alternative technology to demonstrate shunt integrity instead of regular X-ray SS. Favorable shunt visibility without the need for multiple radiation exposures and image processing (such as stitching) results in a significantly shorter examination time and significant less radiation. Copyright © 2018 Elsevier Inc. All rights reserved.

Asians Demonstrate Reduced Sensitivity to Unpredictable Threat: A Preliminary Startle Investigation using Genetic Ancestry in a Multi-Ethnic Sample

PubMed Central

Nelson, Brady D.; Bishop, Jeffrey R.; Sarapas, Casey; Kittles, Rick A.; Shankman, Stewart A.

2014-01-01

Research has indicated that individuals of Asian descent, relative to other racial groups, demonstrate reduced emotional responding and lower prevalence rates of several anxiety disorders. It is unclear though whether these group differences extend to biomarkers of anxiety disorders and whether genetic differences play a role. The present study compared self-identified Caucasians, Latinos, and Asians (total N = 174) on startle response during a baseline period and while anticipating unpredictable threat–a putative biomarker for certain anxiety disorders–as well as predictable threat. In addition, the association between genetic ancestry and startle response was examined within each racial group to determine potential genetic influences on responding. For the baseline period, Asian participants exhibited a smaller startle response relative to Caucasian and Latino participants, who did not differ. Within each racial group, genetic ancestry was associated with baseline startle. Furthermore, genetic ancestry mediated racial group differences in baseline startle. For the threat conditions, a Race × Condition interaction indicated that Asian participants exhibited reduced startle potentiation to unpredictable, but not predicable, threat relative to Caucasian and Latino participants, who did not differ. However, genetic ancestry was not associated with threat-potentiated startle in any racial group. The present study adds to the growing literature on racial differences in emotional responding and provides preliminary evidence suggesting that genetic ancestry may play an important role. Moreover, reduced sensitivity to unpredictable threat may reflect a mechanism for why individuals of Asian descent are at less risk for particular anxiety disorders relative to other racial groups. PMID:24708496

Reduced ventilation-perfusion (V/Q) mismatch following endobronchial valve insertion demonstrated by Gallium-68 V/Q photon emission tomography/computed tomography.

PubMed

Leong, Paul; Le Roux, Pierre-Yves; Callahan, Jason; Siva, Shankar; Hofman, Michael S; Steinfort, Daniel P

2017-09-01

Endobronchial valves (EBVs) are increasingly deployed in the management of severe emphysema. Initial studies focussed on volume reduction as the mechanism, with subsequent improvement in forced expiratory volume in 1 s (FEV 1 ). More recent studies have emphasized importance of perfusion on predicting outcomes, though findings have been inconsistent. Gallium-68 ventilation-perfusion (V/Q) photon emission tomography (PET)/computed tomography (CT) is a novel imaging modality with advantages in spatial resolution, quantitation, and speed over conventional V/Q scintigraphy. We report a pilot case in which V/Q-PET/CT demonstrated discordant findings compared with quantitative CT analysis, and directed left lower lobe EBV placement. The patient experienced a significant improvement in 6-min walk distance (6MWD) without change in spirometry. Post-EBV V/Q-PET/CT demonstrated a marked decrease in unmatched (detrimental) V/Q areas and improvement in overall V/Q matching on post-EBV V/Q-PET/CT. These preliminary novel findings suggest that EBVs improve V/Q matching and may explain the observed functional improvements.

Mixed-methods development of a new patient-reported outcome instrument for chronic low back pain: part 1-the Patient Assessment for Low Back Pain - Symptoms (PAL-S).

PubMed

Martin, Mona L; Blum, Steven I; Liedgens, Hiltrud; Bushnell, Donald M; McCarrier, Kelly P; Hatley, Noël V; Ramasamy, Abhilasha; Freynhagen, Rainer; Wallace, Mark; Argoff, Charles; Eerdekens, Mariёlle; Kok, Maurits; Patrick, Donald L

2018-06-01

We describe the mixed-methods (qualitative and quantitative) development and preliminary validation of the Patient Assessment for Low Back Pain-Symptoms (PAL-S), a patient-reported outcome measure for use in chronic low back pain (cLBP) clinical trials. Qualitative methods (concept elicitation and cognitive interviews) were used to identify and refine symptom concepts and quantitative methods (classical test theory and Rasch measurement theory) were used to evaluate item- and scale-level performance of the measure using an iterative approach. Patients with cLBP participated in concept elicitation interviews (N = 43), cognitive interviews (N = 38), and interview-based assessment of paper-to-electronic mode equivalence (N = 8). A web-based sample of patients with self-reported cLBP participated in quantitative studies to evaluate preliminary (N = 598) and revised (n = 401) drafts and a physician-diagnosed cohort of patients with cLBP (N = 45) participated in preliminary validation of the measure. The PAL-S contained 14 items describing symptoms (overall pain, sharp, prickling, sensitive, tender, radiating, shocking, shooting, burning, squeezing, muscle spasms, throbbing, aching, and stiffness). Item-level performance, scale structure, and scoring seemed to be appropriate. One-week test-retest reproducibility was acceptable (intraclass correlation coefficient 0.81 [95% confidence interval, 0.61-0.91]). Convergent validity was demonstrated with total score and MOS-36 Bodily Pain (Pearson correlation -0.79), Neuropathic Pain Symptom Inventory (0.73), Roland-Morris Disability Questionnaire (0.67), and MOS-36 Physical Functioning (-0.65). Individual item scores and total score discriminated between numeric rating scale tertile groups and painDETECT categories. Respondent interpretation of paper and electronic administration modes was equivalent. The PAL-S has demonstrated content validity and is potentially useful to assess treatment benefit in cLBP clinical trials.

Structured Feedback Training for Time-Out: Efficacy and Efficiency in Comparison to a Didactic Method.

PubMed

Jensen, Scott A; Blumberg, Sean; Browning, Megan

2017-09-01

Although time-out has been demonstrated to be effective across multiple settings, little research exists on effective methods for training others to implement time-out. The present set of studies is an exploratory analysis of a structured feedback method for training time-out using repeated role-plays. The three studies examined (a) a between-subjects comparison to more a traditional didactic/video modeling method of time-out training, (b) a within-subjects comparison to traditional didactic/video modeling training for another skill, and (c) the impact of structured feedback training on in-home time-out implementation. Though findings are only preliminary and more research is needed, the structured feedback method appears across studies to be an efficient, effective method that demonstrates good maintenance of skill up to 3 months post training. Findings suggest, though do not confirm, a benefit of the structured feedback method over a more traditional didactic/video training model. Implications and further research on the method are discussed.

Glyphosate inhibits rust diseases in glyphosate-resistant wheat and soybean.

PubMed

Feng, Paul C C; Baley, G James; Clinton, William P; Bunkers, Greg J; Alibhai, Murtaza F; Paulitz, Timothy C; Kidwell, Kimberlee K

2005-11-29

Glyphosate is a broad-spectrum herbicide used for the control of weeds in glyphosate-resistant crops. Glyphosate inhibits 5-enolpyruvyl shikimate 3-phosphate synthase, a key enzyme in the synthesis of aromatic amino acids in plants, fungi, and bacteria. Studies with glyphosate-resistant wheat have shown that glyphosate provided both preventive and curative activities against Puccinia striiformis f. sp. tritici and Puccinia triticina, which cause stripe and leaf rusts, respectively, in wheat. Growth-chamber studies demonstrated wheat rust control at multiple plant growth stages with a glyphosate spray dose typically recommended for weed control. Rust control was absent in formulation controls without glyphosate, dependent on systemic glyphosate concentrations in leaf tissues, and not mediated through induction of four common systemic acquired resistance genes. A field test with endemic stripe rust inoculum confirmed the activities of glyphosate pre- and postinfestation. Preliminary greenhouse studies also demonstrated that application of glyphosate in glyphosate-resistant soybeans suppressed Asian soybean rust, caused by Phakopsora pachyrhizi.

Studies related to primitive chemistry. A proton and nitrogen-14 nuclear magnetic resonance amino acid and nucleic acid constituents and a and their possible relation to prebiotic

NASA Technical Reports Server (NTRS)

Manatt, S. L.; Cohen, E. A.; Shiller, A. M.; Chan, S. I.

1973-01-01

Preliminary proton nuclear magnetic resonance (NMR) studies were made to determine the applicability of this technique for the study of interactions between monomeric and polymeric amino acids with monomeric nucleic acid bases and nucleotides. Proton NMR results for aqueous solutions (D2O) demonstrated interactions between the bases cytosine and adenine and acidic and aromatic amino acids. Solutions of 5'-AMP admixed with amino acids exhibited more complex behavior but stacking between aromatic rings and destacking at high amino acids concentration was evident. The multisite nature of 5'-AMP was pointed out. Chemical shift changes for adenine and 5'-AMP with three water soluble polypeptides demonstrated that significant interactions exist. It was found that the linewidth-pH profile of each amino acid is unique. It is concluded that NMR techniques can give significant and quantitative data on the association of amino acid and nucleic acid constituents.

An Oil-Free Thrust Foil Bearing Facility Design, Calibration, and Operation

NASA Technical Reports Server (NTRS)

Bauman, Steve

2005-01-01

New testing capabilities are needed in order to foster thrust foil air bearing technology development and aid its transition into future Oil-Free gas turbines. This paper describes a new test apparatus capable of testing thrust foil air bearings up to 100 mm in diameter at speeds to 80,000 rpm and temperatures to 650 C (1200 F). Measured parameters include bearing torque, load capacity, and bearing temperatures. This data will be used for design performance evaluations and for validation of foil bearing models. Preliminary test results demonstrate that the rig is capable of testing thrust foil air bearings under a wide range of conditions which are anticipated in future Oil-Free gas turbines. Torque as a function of speed and temperature corroborates results expected from rudimentary performance models. A number of bearings were intentionally failed with no resultant damage whatsoever to the test rig. Several test conditions (specific speeds and loads) revealed undesirable axial shaft vibrations which have been attributed to the magnetic bearing control system and are under study. Based upon these preliminary results, this test rig will be a valuable tool for thrust foil bearing research, parametric studies and technology development.

Can TRUS Power Doppler Predict the Preservation of Erectile Function in HIFU Treatment of Localised Prostate Cancer? — A Preliminary Study

NASA Astrophysics Data System (ADS)

Hoh, I. M.; Calleary, J. G.; Moore, C.; Emberton, M.; Allen, C.

2006-05-01

Perhaps the single most significant unifying feature in men diagnosed with organ confined prostate cancer is the hope of erectile preservation in the treatment that offers cure. Although it is not 100% certain that the preservation of neurovascular bundle (NVB) can actually lead to intact sexual function, there is evidence that non-sparing nerve radical prostatectomy has a much higher incidence of impotence compared to nerve-sparing ones. The idea to monitor NVB flow can be realized using a simple power Doppler technique that was done before and after HIFU. The NVB flow was found intact in all patients (n=14). Tumescence returned in 93% of patients with a mean time of 6 weeks for this to occur. The erectile function score, IIEF-15 decreased by a third but shows a trend towards recovery. This preliminary study demonstrates the feasibility of transrectal power Doppler as a monitoring tool to provide immediate feedback on the NVB flow which was found intact in all patients. Although early reports of the tumescence proved encouraging, its full impact on erectile function will require longer follow-up.

Webcam mouse using face and eye tracking in various illumination environments.

PubMed

Lin, Yuan-Pin; Chao, Yi-Ping; Lin, Chung-Chih; Chen, Jyh-Horng

2005-01-01

Nowadays, due to enhancement of computer performance and popular usage of webcam devices, it has become possible to acquire users' gestures for the human-computer-interface with PC via webcam. However, the effects of illumination variation would dramatically decrease the stability and accuracy of skin-based face tracking system; especially for a notebook or portable platform. In this study we present an effective illumination recognition technique, combining K-Nearest Neighbor classifier and adaptive skin model, to realize the real-time tracking system. We have demonstrated that the accuracy of face detection based on the KNN classifier is higher than 92% in various illumination environments. In real-time implementation, the system successfully tracks user face and eyes features at 15 fps under standard notebook platforms. Although KNN classifier only initiates five environments at preliminary stage, the system permits users to define and add their favorite environments to KNN for computer access. Eventually, based on this efficient tracking algorithm, we have developed a "Webcam Mouse" system to control the PC cursor using face and eye tracking. Preliminary studies in "point and click" style PC web games also shows promising applications in consumer electronic markets in the future.

Sensitive test for sea mine identification based on polarization-aided image processing.

PubMed

Leonard, I; Alfalou, A; Brosseau, C

2013-12-02

Techniques are widely sought to detect and identify sea mines. This issue is characterized by complicated mine shapes and underwater light propagation dependencies. In a preliminary study we use a preprocessing step for denoising underwater images before applying the algorithm for mine detection. Once a mine is detected, the protocol for identifying it is activated. Among many correlation filters, we have focused our attention on the asymmetric segmented phase-only filter for quantifying the recognition rate because it allows us to significantly increase the number of reference images in the fabrication of this filter. Yet they are not entirely satisfactory in terms of recognition rate and the obtained images revealed to be of low quality. In this report, we propose a way to improve upon this preliminary study by using a single wavelength polarimetric camera in order to denoise the images. This permits us to enhance images and improve depth visibility. We present illustrative results using in situ polarization imaging of a target through a milk-water mixture and demonstrate that our challenging objective of increasing the detection rate and decreasing the false alarm rate has been achieved.

Development of a near-infrared spectroscopic system for monitoring urine glucose level for the use of long-term home healthcare

NASA Astrophysics Data System (ADS)

Tanaka, Shinobu; Hayakawa, Yuuto; Ogawa, Mitsuhiro; Yamakoshi, Ken-ichi

2010-08-01

We have been developing a new technique for measuring urine glucose concentration using near infrared spectroscopy (NIRS) in conjunction with the Partial Least Square (PLS) method. In the previous study, we reported some results of preliminary experiments for assessing feasibility of this method using a FT-IR spectrometer. In this study, considering practicability of the system, a flow-through cell with the optical path length of 10 mm was newly introduced. Accuracy of the system was verified by the preliminary experiments using urine samples. From the results obtained, it was clearly demonstrated that the present method had a capability of predicting individual urine glucose level with reasonable accuracy (the minimum value of standard error of prediction: SEP = 22.3 mg/dl) and appeared to be a useful means for long-term home health care. However, mean value of SEP obtained by the urine samples from ten subjects was not satisfactorily low (53.7 mg/dl). For improving the accuracy, (1) mechanical stability of the optical system should be improved, (2) the method for normalizing the spectrum should be reconsidered, and (3) the number of subject should be increased.

Design concept of K-DEMO for near-term implementation

NASA Astrophysics Data System (ADS)

Kim, K.; Im, K.; Kim, H. C.; Oh, S.; Park, J. S.; Kwon, S.; Lee, Y. S.; Yeom, J. H.; Lee, C.; Lee, G.-S.; Neilson, G.; Kessel, C.; Brown, T.; Titus, P.; Mikkelsen, D.; Zhai, Y.

2015-05-01

A Korean fusion energy development promotion law (FEDPL) was enacted in 2007. As a following step, a conceptual design study for a steady-state Korean fusion demonstration reactor (K-DEMO) was initiated in 2012. After the thorough 0D system analysis, the parameters of the main machine characterized by the major and minor radii of 6.8 and 2.1 m, respectively, were chosen for further study. The analyses of heating and current drives were performed for the development of the plasma operation scenarios. Preliminary results on lower hybrid and neutral beam current drive are included herein. A high performance Nb3Sn-based superconducting conductor is adopted, providing a peak magnetic field approaching 16 T with the magnetic field at the plasma centre above 7 T. Pressurized water is the prominent choice for the main coolant of K-DEMO when the balance of plant development details is considered. The blanket system adopts a ceramic pebble type breeder. Considering plasma performance, a double-null divertor is the reference configuration choice of K-DEMO. For a high availability operation, K-DEMO incorporates a design with vertical maintenance. A design concept for K-DEMO is presented together with the preliminary design parameters.

Transcriptome analysis of Spodoptera frugiperda Sf9 cells reveals putative apoptosis-related genes and a preliminary apoptosis mechanism induced by azadirachtin.

PubMed

Shu, Benshui; Zhang, Jingjing; Sethuraman, Veeran; Cui, Gaofeng; Yi, Xin; Zhong, Guohua

2017-10-16

As an important botanical pesticide, azadirachtin demonstrates broad insecticidal activity against many agricultural pests. The results of a previous study indicated the toxicity and apoptosis induction of azadirachtin in Spodoptera frugiperda Sf9 cells. However, the lack of genomic data has hindered a deeper investigation of apoptosis in Sf9 cells at a molecular level. In the present study, the complete transcriptome data for Sf9 cell line was accomplished using Illumina sequencing technology, and 97 putative apoptosis-related genes were identified through BLAST and KEGG orthologue annotations. Fragments of potential candidate apoptosis-related genes were cloned, and the mRNA expression patterns of ten identified genes regulated by azadirachtin were examined using qRT-PCR. Furthermore, Western blot analysis showed that six putative apoptosis-related proteins were upregulated after being treated with azadirachtin while the protein Bcl-2 were downregulated. These data suggested that both intrinsic and extrinsic apoptotic signal pathways comprising the identified potential apoptosis-related genes were potentially active in S. frugiperda. In addition, the preliminary results revealed that caspase-dependent or caspase-independent apoptotic pathways could function in azadirachtin-induced apoptosis in Sf9 cells.

Measuring attitudes towards suicide: Preliminary evaluation of an attitude towards suicide scale.

PubMed

Cwik, Jan Christopher; Till, Benedikt; Bieda, Angela; Blackwell, Simon E; Walter, Carolin; Teismann, Tobias

2017-01-01

Our study aimed to validate a previously published scale assessing attitudes towards suicide. Factor structure, convergent and discriminant validity, and predictive validity were investigated. Adult German participants (N=503; mean age=24.74years; age range=18-67years) anonymously completed a set of questionnaires. An exploratory factor analysis was conducted, and incongruous items were deleted. Subsequently, scale properties of the reduced scale and its construct validity were analyzed. A confirmatory factor analysis was then conducted in an independent sample (N=266; mean age=28.77years; age range=18-88years) to further confirm the factor structure of the questionnaire. Parallel analysis indicated a three-factor solution, which was also supported by confirmatory factor analysis: right to commit suicide, interpersonal gesture and resilience. The subscales demonstrated acceptable construct and discriminant validity. Cronbach's α for the subscales ranged from 0.67 to 0.83, explaining 49.70% of the total variance. Positive attitudes towards suicide proved to be predictive of suicide risk status, providing preliminary evidence for the utility of the scale. Future studies aiming to reproduce the factor structure in a more heterogeneous sample are warranted. Copyright © 2016 Elsevier Inc. All rights reserved.

FTY720-loaded poly(DL-lactide-co-glycolide) electrospun scaffold significantly increases microvessel density over 7 days in streptozotocin-induced diabetic C57b16/J mice: preliminary results.

PubMed

Bowers, D T; Chhabra, P; Langman, L; Botchwey, E A; Brayman, K L

2011-11-01

Nanofiber scaffolds could improve islet transplant success by physically mimicking the shape of extracellular matrix and by acting as a drug-delivery vehicle. Scaffolds implanted in alternate transplant sites must be prevascularized or very quickly vascularized following transplantation to prevent hypoxia-induced islet necrosis. The local release of the S1P prodrug FTY720 induces diameter enlargement and increases in length density. The objective of this preliminary study was to evaluate length and diameter differences between diabetic and nondiabetic animals implanted with FTY720-containing electrospun scaffolds using intravital imaging of dorsal skinfold window chambers. Electrospun mats of randomly oriented fibers we created from polymer solutions of PLAGA (50:50 LA:GA) with and without FTY720 loaded at a ratio of 1:200 (FTY720:PLAGA by wt). The implanted fiber mats were 4 mm in diameter and ∼0.2 mm thick. Increases in length density and vessel diameter were assessed by automated analysis of images over 7 days in RAVE, a Matlab program. Image analysis of repeated measures of microvessel metrics demonstrated a significant increase in the length density from day 0 to day 7 in the moderately diabetic animals of this preliminary study (P < .05). Furthermore, significant differences in length density at day 0 and day 3 were found between recently STZ-induced moderately diabetic and nondiabetic animals in response to FTY720 local release (P < .05, Student t test). Driving the islet revascularization process using local release of factors, such as FTY720, from biodegradable polymers makes an attractive system for the improvement of islet transplant success. Preliminary study results suggest that a recently induced moderately diabetic state may potentiate the mechanism by which local release of FTY720 from polymer fibers increases length density of microvessels. Therefore, local release of S1P receptor-targeted drugs is under further investigation for improvement of transplanted islet function. Copyright © 2011. Published by Elsevier Inc.

Collaborative Care for Patients With Severe Personality Disorders: Preliminary Results and Active Ingredients From a Pilot Study (Part I).

PubMed

Stringer, Barbara; van Meijel, Berno; Karman, Pieter; Koekkoek, Bauke; Hoogendoorn, Adriaan W; Kerkhof, Ad J F M; Beekman, Aartjan T F

2015-07-01

To test if a collaborative care program (CCP) with nurses in a coordinating position is beneficial for patients with severe personality disorders. A pilot study with a comparative multiple case study design using mixed methods investigating active ingredients and preliminary results. Most patients, their informal caregivers, and nurses value (parts of) the CCP positively; preliminary results show a significant decrease in severity of borderline symptoms. With the CCP, we may expand the supply of available treatments for patients with (severe) personality disorders, but a larger randomized controlled trial is warranted to confirm our preliminary results. © 2014 Wiley Periodicals, Inc.

Global Lakes Sentinel Services: Monitoring Water Quality Trends in Deep, Clear Lakes to Detect Causes and Effects of Changes in Trophic Status

NASA Astrophysics Data System (ADS)

Poser, Kathrin; Peters, Steef; Hommersom, Annelies; Giardino, Claudia; Bresciani, Mariano; Cazzaniga, Ilaria; Schenk, Karin; Heege, Thomas; Philipson, Petra; Ruescas, Ana; Bottcher, Martin; Stelzer, Kerstin

2015-12-01

The GLaSS project develops a prototype infrastructure to ingest and process large amounts of Sentinel-2 and Sentinel-3 data for lakes and reservoirs. To demonstrate the value of satellite observations for the management of aquatic ecosystems, global case studies are performed addressing different types of lakes with their respective problems and management questions. One of these case studies is concentrating on deep clear lakes worldwide. The aim of this case study is to evaluate trends of chlorophyll-a concentrations (Chl-a) as a proxy of the trophic status based on the MERIS full resolution data archive. Some preliminary results of this case study are presented here.

Individual differences in situation awareness: Validation of the Situationism Scale

PubMed Central

Roberts, Megan E.; Gibbons, Frederick X.; Gerrard, Meg; Klein, William M. P.

2015-01-01

This paper concerns the construct of lay situationism—an individual’s belief in the importance of a behavior’s context. Study 1 identified a 13-item Situationism Scale, which demonstrated good reliability and validity. In particular, higher situationism was associated with greater situation-control (strategies to manipulate the environment in order to avoid temptation). Subsequent laboratory studies indicated that people higher on the situationism subscales used greater situation-control by sitting farther from junk food (Study 2) and choosing to drink non-alcoholic beverages before a cognitive task (Study 3). Overall, findings provide preliminary support for the psychometric validity and predictive utility of the Situationism Scale and offer this individual difference construct as a means to expand self-regulation theory. PMID:25329242

A Systems Analysis of the Library and Information Science Statistical Data System: The Preliminary Study. Interim Report.

ERIC Educational Resources Information Center

Hamburg, Morris; And Others

The long-term goal of this investigation is to design and establish a national model for a system of library statistical data. This is a report on The Preliminary Study which was carried out over an 11-month period ending May, 1969. The objective of The Preliminary Study was to design and delimit The Research Investigation in the most efficient…

Multiple autoimmune diseases syndrome in Italian Greyhounds: preliminary studies of genome-wide diversity and possible associations within the dog leukocyte antigen (DLA) complex.

PubMed

Pedersen, Niels C; Liu, Hongwei; Greenfield, Daniel L; Echols, Layle Griffioen

2012-01-15

A disorder manifested by multiple autoimmune disorders, and resembling autoimmune polyendocrine syndrome type 2 (APS-2) in humans, may exist in Italian Greyhounds. The incidence of this disorder is increasing and its potential impact on the health of the breed is becoming of great concern. The aims of the present study were to document the existence of this syndrome, conduct a preliminary assessment of genetic diversity across the breed and within affected and unaffected dogs, determine whether the disorder associates with the dog leukocyte antigen (DLA) complex, and demonstrate similarities to APS-2 of humans. To these ends, information on disease, pedigrees, and blood or buccal swab samples were collected from affected and healthy Italian Greyhounds and extracted DNA analyzed. Analysis of Y chromosome markers and mitochondrial DNA sequences showed that Italian Greyhounds evolved from a single patriline and two major and four minor matrilines. A panel of 24 highly polymorphic simple tandem repeat (STR) markers across 20 autosomes demonstrated that affected and unaffected dogs were not distinguishable from the population as a whole by heterozygosity, F-statistics, and principal component analysis (PCA). However, analysis of allele frequencies at each STR loci identified regions of increased or decreased disease risk on four chromosomes. A similar genetic analysis using 109 single nucleotide polymorphisms (SNPs) across the DLA region showed differences between affected and unaffected dogs. PCA and zygosity mapping of DLA SNPs from unrelated dogs demonstrated two distinct subpopulations among the affected individuals. One population was very homozygous and the other closely resembled unaffected dogs in its heterozygosity, suggesting the evolution of a disease prone bloodline as a result of non-random selection. Exon 2 sequencing of the DLA class II genes demonstrated 5-8 alleles at each locus and 14 three loci haplotypes. Two specific haplotypes containing DRB1*00203 or DRB1*02901 were associated with increased disease risk in about one-third of affected dogs. However, high density SNP association mapping across the DLA region and CFA12 did not corroborate the association. Copyright © 2011 Elsevier B.V. All rights reserved.

Obese individuals with more components of the metabolic syndrome and/or prediabetes demonstrate decreased activation of reward-related brain centers in response to food cues in both the fed and fasting states: A preliminary fMRI study

PubMed Central

Farr, Olivia M.; Mantzoros, Christos S.

2016-01-01

It remains unknown whether obese individuals with more components of the metabolic syndrome and/or prediabetes demonstrate altered activation of brain centers in response to food cues. We examined obese prediabetics (n=26) vs. obese nondiabetics (n=11) using fMRI. We also performed regression analyses on the basis of the number of MetS components per subject. Obese individuals with prediabetes have decreased activation of the reward-related putamen in the fasting state and decreased activation of the salience- and reward-related insula after eating. Obese individuals with more components of MetS demonstrate decreased activation of the putamen while fasting. All these activations remain significant when corrected for BMI, waist circumference (WC), HbA1c and gender. Decreased activation in reward-related brain areas between obese individuals is more pronounced in subjects with prediabetes and MetS. Prospective studies are needed to quantify their contributions to the development of prediabetes/MetS and to study whether these conditions may predispose to the exacerbation of obesity and the development of comorbidities over time. PMID:28017966

Testimony psychotherapy in Bosnian refugees: a pilot study.

PubMed

Weine, S M; Kulenovic, A D; Pavkovic, I; Gibbons, R

1998-12-01

The authors sought to describe the use of the testimony method of psychotherapy in a group of traumatized adult refugees from genocide in Bosnia-Herzegovina. The subjects were 20 Bosnian refugees in Chicago who gave written informed consent to participate in a case series study of testimony psychotherapy. All subjects received testimony psychotherapy, averaging six sessions, approximately 90 minutes, weekly or biweekly. Subjects received standardized instruments for posttraumatic stress disorder (PTSD), depression, traumatic events, global functioning, and prior psychiatric history. The instruments were administered before treatment, at the conclusion of the treatment, and at the 2- and 6-month follow-ups. The posttreatment assessments demonstrated significant decreases in the rate of PTSD diagnosis, PTSD symptom severity, and the severity of reexperiencing, avoidance, and hyperarousal symptom clusters. Depressive symptoms demonstrated a significant decrease, and there was a significant increase in scores on the Global Assessment of Functioning Scale. Two-month and 6-month follow-up assessments demonstrated further significant decreases in all symptoms and an increase in scores on the Global Assessment of Functioning Scale. This pilot study provides preliminary evidence that testimony psychotherapy may lead to improvements in PTSD and depressive symptoms, as well as to improvement of functioning, in survivors of state-sponsored violence.

43 CFR 4.1351 - Preliminary finding by OSM.

Code of Federal Regulations, 2010 CFR

2010-10-01

... APPEALS PROCEDURES Special Rules Applicable to Surface Coal Mining Hearings and Appeals Request for...(c) of the Act, 30 U.s.c. 1260(c) (federal Program; Federal Lands Program; Federal Program for Indian... or has controlled surface coal mining and reclamation operations with a demonstrated pattern of...

Coal liquefaction demonstration plant near Morgantown, West Virgina; water assessment report. Summary report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1980-08-21

This assessment report is for public review and comment and was prepared under the provision of Sect. 13(b) of the 1974 Federal Nonnuclear Energy Research and Development Act. It includes only a preliminary assessment of the commercial project as currently planned.

APPLICATION OF FINE SCALE AIR TOXICS MODELING WITH CMAQ TO HAPEM5

EPA Science Inventory

This paper provides a preliminary demonstration of the EPA neighborhood scale modeling paradigm for air toxics by linking concentration from the Community Multiscale Air Quality (CMAQ) modeling system to the fifth version of the Hazardous Pollutant Exposure Model (HAPEM5). For t...

PRELIMINARY ASSESSMENT OF WORKER AND AMBIENT AIR EXPOSURES DURING SOIL REMEDIATION TECHNOLOGY DEMONSTRATIONS

EPA Science Inventory

Hazardous waste site remediation workers or neighboring residents may be exposed to particulates during the remediation of lead contaminated soil sites. An industrial hygiene survey and air monitoring program for both lead and dust were performed during initial soil sampling acti...

Mass Transportation in Massachusetts : demonstration project progress report no. 6 - bus and parking experiments

DOT National Transportation Integrated Search

1964-04-10

This sixth progress report, as with all previous such reports, has been prepared by the MTC staff to disseminate the results of the individual experiments and tentative preliminary conclusions so that the full Commission might have the benefit of wid...

Los Angeles congestion reduction demonstration (Metro ExpressLanes) program. National evaluation : transit system data test plan.

DOT National Transportation Integrated Search

1998-09-01

This flyer summarizes the activities and results of a preliminary human factors review for the Intelligent Vehicle Initiative (IVI) Program. As part of the IVI program, the Federal Highway Administration funded a project to investigate the human fact...

Can a genetically-modified organism-containing diet influence embryo development? A preliminary study on pre-implantation mouse embryos.

PubMed

Cisterna, B; Flach, F; Vecchio, L; Barabino, S M L; Battistelli, S; Martin, T E; Malatesta, M; Biggiogera, M

2008-01-01

In eukaryotic cells, pre-mRNAs undergo several transformation steps to generate mature mRNAs. Recent studies have demonstrated that a diet containing a genetically modified (GM) soybean can induce modifications of nuclear constituents involved in RNA processing in some tissues of young, adult and old mice. On this basis, we have investigated the ultrastructural and immunocytochemical features of pre-implantation embryos from mice fed either GM or non- GM soybean in order to verify whether the parental diet can affect the morpho-functional development of the embryonic ribonucleoprotein structural constituents involved in pre-mRNA pathways. Morphological observations revealed that the general aspect of embryo nuclear components is similar in the two experimental groups. However, immunocytochemical and in situ hybridization results suggest a temporary decrease of pre-mRNA transcription and splicing in 2-cell embryos and a resumption in 4-8-cell embryos from mice fed GM soybean; moreover, pre-mRNA maturation seems to be less efficient in both 2-cell and 4-8-cell embryos from GM-fed mice than in controls. Although our results are still preliminary and limited to the pre-implantation phases, the results of this study encourage deepening on the effects of food components and/or contaminants on embryo development.

The effects of workload on respiratory variables in simulated flight: a preliminary study.

PubMed

Karavidas, Maria Katsamanis; Lehrer, Paul M; Lu, Shou-En; Vaschillo, Evgeny; Vaschillo, Bronya; Cheng, Andrew

2010-04-01

In this pilot study, we investigated respiratory activity and end-tidal carbon dioxide (P(et)CO(2)) during exposure to varying levels of work load in a simulated flight environment. Seven pilots (age: 34-60) participated in a one-session test on the Boeing 737-800 simulator. Physiological data were collected while pilots wore an ambulatory multi-channel recording device. Respiratory variables, including inductance plethysmography (respiratory pattern) and pressure of end-tidal carbon dioxide (P(et)CO(2)), were collected demonstrating change in CO(2) levels proportional to changes in flight task workload. Pilots performed a set of simulation flight tasks. Pilot performance was rated for each task by a test pilot; and self-report of workload was taken using the NASA-TLX scale. Mixed model analysis revealed that respiration rate and minute ventilation are significantly associated with workload levels and evaluator scores controlling for "vanilla baseline" condition. Hypocapnia exclusively occurred in tasks where pilots performed more poorly. This study was designed as a preliminary investigation in order to develop a psychophysiological assessment methodology, rather than to offer conclusive findings. The results show that the respiratory system is very reactive to high workload conditions in aviation and suggest that hypocapnia may pose a flight safety risk under some circumstances. Copyright © 2010 Elsevier B.V. All rights reserved.

Early maladaptive schemas and aggressive sexual behavior: a preliminary study with male college students.

PubMed

Sigre-Leirós, Vera Lúcia; Carvalho, Joana; Nobre, Pedro

2013-07-01

The influence of adverse early attachment experiences on the development of aggressive sexual behavior has been demonstrated. Nonetheless, there is a gap in the literature regarding the conceptualization of this behavior according to developmental psychopathology models. The purpose of the present study was to investigate a potential association between Early Maladaptive Schemas (EMSs) and aggressive sexual behavior. A total of 166 male college students participated in the study. Participants were divided into two comparative groups according to data from the Sexual Experiences Survey-Short Form Perpetration (SES-SFP): Group of individuals with history of aggressive sexual behavior (N = 37) and Group of individuals without history of aggressive sexual behavior (N = 129). Aggressive sexual behavior was measured by the SES-SFP, and EMSs were measured by the Young Schema Questionnaire (YSQ-S3). Results showed that students who have committed any form of sexually aggressive behavior exhibited significantly higher levels of EMSs from the Disconnection and Rejection domain (namely, Mistrust/Abuse schema), from the Impaired Autonomy and Performance domain (namely, Dependence/Incompetence schema), and from the Overvigilance and Inhibition domain (namely, Negativity/Pessimism schema). These preliminary findings suggest that the EMSs were associated with aggressive sexual behavior, but further investigation is warranted. © 2012 International Society for Sexual Medicine.

Targeting Alertness to Improve Cognition in Older Adults: A Preliminary Report of Benefits in Executive Function and Skill Acquisition

PubMed Central

Van Vleet, Thomas M.; DeGutis, Joseph M.; Merzenich, Michael M.; Simpson, Gregory V.; Zomet, Ativ; Dabit, Sawsan

2016-01-01

Efficient self-regulation of alertness declines with age exacerbating normal declines in performance across multiple cognitive domains, including learning and skill acquisition. Previous cognitive intervention studies have shown that it is possible to enhance alertness in patients with acquired brain injury and marked attention impairments, and that this benefit generalizes to improvements in more global cognitive functions. In the current preliminary studies, we sought to test whether this approach, that targets both tonic (over a period of minutes) and phasic (moment-to-moment) alertness, can improve key executive functioning declines in older adults, and enhance the rate of skill acquisition. The results of both experiments 1 and 2 demonstrate that, compared to active control training, alertness training significantly enhanced performance in several validated executive function measures. In experiment 2, alertness training significantly improved skill acquisition compared to active control training in a well-characterized speed of processing task, with the largest benefits shown in the most challenging speed of processing blocks. The results of the current study suggest that targeting intrinsic alertness in cognitive training provides a novel approach to improve executive functions in older adults and may be a useful adjunct treatment to enhance benefits gained in other clinically validated treatments. PMID:27372902

Science-based HRA: experimental comparison of operator performance to IDAC (Information-Decision-Action Crew) simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shirley, Rachel; Smidts, Carol; Boring, Ronald

Information-Decision-Action Crew (IDAC) operator model simulations of a Steam Generator Tube Rupture are compared to student operator performance in studies conducted in the Ohio State University’s Nuclear Power Plant Simulator Facility. This study is presented as a prototype for conducting simulator studies to validate key aspects of Human Reliability Analysis (HRA) methods. Seven student operator crews are compared to simulation results for crews designed to demonstrate three different decision-making strategies. The IDAC model used in the simulations is modified slightly to capture novice behavior rather that expert operators. Operator actions and scenario pacing are compared. A preliminary review of availablemore » performance shaping factors (PSFs) is presented. After the scenario in the NPP Simulator Facility, student operators review a video of the scenario and evaluate six PSFs at pre-determined points in the scenario. This provides a dynamic record of the PSFs experienced by the OSU student operators. In this preliminary analysis, Time Constraint Load (TCL) calculated in the IDAC simulations is compared to TCL reported by student operators. We identify potential modifications to the IDAC model to develop an “IDAC Student Operator Model.” This analysis provides insights into how similar experiments could be conducted using expert operators to improve the fidelity of IDAC simulations.« less

Preliminary Evidence Assessing Social-Emotional Competences in Deaf and Hard of Hearing Infants and Toddlers Using a New Parent Questionnaire.

PubMed

Hintermair, Manfred; Sarimski, Klaus; Lang, Markus

2017-04-01

Social-emotional competences are an important developmental domain for deaf and hard of hearing (DHH) children and early diagnosis of problems is needed to ensure that DHH children receive appropriate support in this domain. In order to explore the usefulness of an instrument, which was recently developed for very young children, two studies in DHH infants and toddlers were conducted from Germany using the Social-Emotional Assessment/Evaluation Measure (Squires et al. (2013). Social-Emotional Assessment/Evaluation Measure (SEAM). Baltimore, ML: Brooks). Preliminary analysis of data obtained from a sample of 182 DHH children aged between 2 and 36 months (Study 1) suggests that it provides valid, reliable data and is suitable for use in practice. The data also corroborate well-known findings from other research in deaf education, in particular the role of parental responsivity for the development of social-emotional competences. Study 2 documents the consistency of evaluations of 44 DHH children by their mothers and by early intervention providers using the scales. Overall, the results suggest that this new evaluation instrument has potential applications in deaf educational practice but further research is needed to demonstrate its full value. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Anti-conjunctivitis effect of fresh juice of xGraptoveria (Crassulaceae): A phytochemical and ethnobotanical study.

PubMed

Markova, Nadezhda V; Batovska, Daniela I; Kozuharova, Ekaterina K; Enchev, Venelin G

2015-01-01

The parent of xGraptoveria, Graptopetalum paraguayense, is used in Chinese folk medicine for alleviating hepatic disorders, detumescence and detoxication, lowering of blood pressure, inhibition of cancer cells, exerting diuretic effects, relieving pain and infections. No data are available regarding its anti-conjunctivitis effect. The aim of this preliminary study is to test the anti-conjunctivitis properties of xGraptoveria (Crassulaceae) and to identify its bioactive constituents. Fresh watery juice of leaves of xGraptoveria was extracted with n-butanol and the extract was analyzed using gas chromatography-mass spectrometry (GC/MS). The ethnobotanical appraisal of the anti-conjunctivitis properties of xGraptoveria was based on 11 interviews about the symptoms against which this plant demonstrated positive effect. Fresh juice of xGraptoveria leaves applied directly to the irritated eye 2 times per day cured conjunctivitis in all reported cases. The main groups of organic compounds identified by GC/MS analysis in the fresh extracted leaf juice of xGraptoveria were: Alkylamines, hydroxycarboxylic acids, aliphatic and aromatic carboxylic acids, amino acids, alcohols, aromatic and aliphatic hydrocarbons. In this preliminary study, it is suggested that xGraptoveria exerts anti-conjunctivitis activity, through synergistic effect of different chemical compounds, most probably alkylamines and mainly hydroxycarboxylic, aliphatic, and aromatic carboxylic acids.

Anti-conjunctivitis effect of fresh juice of xGraptoveria (Crassulaceae): A phytochemical and ethnobotanical study

PubMed Central

Markova, Nadezhda V.; Batovska, Daniela I.; Kozuharova, Ekaterina K.; Enchev, Venelin G.

2015-01-01

Aim: The parent of xGraptoveria, Graptopetalum paraguayense, is used in Chinese folk medicine for alleviating hepatic disorders, detumescence and detoxication, lowering of blood pressure, inhibition of cancer cells, exerting diuretic effects, relieving pain and infections. No data are available regarding its anti-conjunctivitis effect. The aim of this preliminary study is to test the anti-conjunctivitis properties of xGraptoveria (Crassulaceae) and to identify its bioactive constituents. Materials and Methods: Fresh watery juice of leaves of xGraptoveria was extracted with n-butanol and the extract was analyzed using gas chromatography-mass spectrometry (GC/MS). The ethnobotanical appraisal of the anti-conjunctivitis properties of xGraptoveria was based on 11 interviews about the symptoms against which this plant demonstrated positive effect. Results: Fresh juice of xGraptoveria leaves applied directly to the irritated eye 2 times per day cured conjunctivitis in all reported cases. The main groups of organic compounds identified by GC/MS analysis in the fresh extracted leaf juice of xGraptoveria were: Alkylamines, hydroxycarboxylic acids, aliphatic and aromatic carboxylic acids, amino acids, alcohols, aromatic and aliphatic hydrocarbons. Conclusion: In this preliminary study, it is suggested that xGraptoveria exerts anti-conjunctivitis activity, through synergistic effect of different chemical compounds, most probably alkylamines and mainly hydroxycarboxylic, aliphatic, and aromatic carboxylic acids. PMID:26401380

A 100 kW-Class Technology Demonstrator for Space Solar Power

NASA Astrophysics Data System (ADS)

Howell, J.; Carrington, C.; Day, G.

2004-12-01

A first step in the development of solar power from space is the flight demonstration of critical technologies. These fundamental technologies include efficient solar power collection and generation, power management and distribution, and thermal management. In addition, the integration and utilization of these technologies into a viable satellite bus could provide an energy-rich platform for a portfolio of payload experiments such as wireless power transmission (WPT). This paper presents the preliminary design of a concept for a 100 kW-class free-flying platform suitable for flight demonstration of Space Solar Power (SSP) technology experiments.

Experimental Investigation and Demonstration of Rotary-Wing Technologies for Flight in the Atmosphere of Mars

NASA Technical Reports Server (NTRS)

Young, L. A.; Derby, M. R.; Demblewski, R.; Navarrete, J.

2002-01-01

This paper details ongoing work at NASA Ames Research Center as to experimental investigations and demonstrations related to rotary-wing technologies that might be applied to flight in the atmosphere of Mars. Such Mars rotorcraft would provide a 'three-dimensional mobility' to the exploration of the Red Planet. Preliminary results from isolated rotor testing in Mars-representative atmospheric densities, as well as progress towards coaxial test stand development are discussed. Additionally, work towards the development and use of surrogate flight vehicles -- in the terrestrial environment -- to demonstrate key technologies is also summarized.

Preliminary Development of a Multifunctional Hot Structure Heat Shield

NASA Technical Reports Server (NTRS)

Walker, Sandra P.; Daryabeigi, Kamran; Samareh, Jamshid A.; Armand, Sasan C.; Perino, Scott V

2014-01-01

Development of a Multifunctional Hot Structure Heat Shield concept has initiated with the goal to provide advanced technology with significant benefits compared to the current state of the art heat shield technology. The concept is unique in integrating the function of the thermal protection system with the primary load carrying structural component. An advanced carbon-carbon material system has been evaluated for the load carrying structure, which will be utilized on the outer surface of the heat shield, and thus will operate as a hot structure exposed to the severe aerodynamic heating associated with planetary entry. Flexible, highly efficient blanket insulation has been sized for use underneath the hot structure to maintain desired internal temperatures. The approach was to develop a preliminary design to demonstrate feasibility of the concept. The preliminary results indicate that the concept has the potential to save both mass and volume with significantly less recession compared to traditional heat shield designs, and thus provide potential to enable new planetary missions.

Preliminary identification of unicellular algal genus by using combined confocal resonance Raman spectroscopy with PCA and DPLS analysis

NASA Astrophysics Data System (ADS)

He, Shixuan; Xie, Wanyi; Zhang, Ping; Fang, Shaoxi; Li, Zhe; Tang, Peng; Gao, Xia; Guo, Jinsong; Tlili, Chaker; Wang, Deqiang

2018-02-01

The analysis of algae and dominant alga plays important roles in ecological and environmental fields since it can be used to forecast water bloom and control its potential deleterious effects. Herein, we combine in vivo confocal resonance Raman spectroscopy with multivariate analysis methods to preliminary identify the three algal genera in water blooms at unicellular scale. Statistical analysis of characteristic Raman peaks demonstrates that certain shifts and different normalized intensities, resulting from composition of different carotenoids, exist in Raman spectra of three algal cells. Principal component analysis (PCA) scores and corresponding loading weights show some differences from Raman spectral characteristics which are caused by vibrations of carotenoids in unicellular algae. Then, discriminant partial least squares (DPLS) classification method is used to verify the effectiveness of algal identification with confocal resonance Raman spectroscopy. Our results show that confocal resonance Raman spectroscopy combined with PCA and DPLS could handle the preliminary identification of dominant alga for forecasting and controlling of water blooms.

Developing evaluation scales for horticultural therapy.

PubMed

Im, Eun-Ae; Park, Sin-Ae; Son, Ki-Cheol

2018-04-01

This study developed evaluation scales for measuring the effects of horticultural therapy in practical settings. Qualitative and quantitative research, including three preliminary studies and a main study, were conducted. In the first study, a total of 779 horticultural therapists answered an open-end questionnaire based on 58 items about elements of occupational therapy and seven factors about singularity of horticultural therapy. In the second study, 20 horticultural therapists participated in in-depth interviews. In the third study, a Delphi method was conducted with 24 horticultural therapists to build a model of assessment indexes and ensure the validity. In the final study, the reserve scales were tested by 121 horticultural therapists in their practical settings for 1045 clients, to verify their reliability and validity. Preliminary questions in the effects area of horticultural therapy were developed in the first study, and validity for the components in the second study. In the third study, an expert Delphi survey was conducted as part of content validity verification of the preliminary tool of horticultural therapy for physical, cognitive, psychological-emotional, and social areas. In the final study, the evaluation tool, which verified the construct, convergence, discriminant, and predictive validity and reliability test, was used to finalise the evaluation tool. The effects of horticultural therapy were classified as four different aspects, namely, physical, cognitive, psycho-emotional, and social, based on previous studies on the effects of horticultural therapy. 98 questions in the four aspects were selected as reserve scales. The reliability of each scale was calculated as 0.982 in physical, 0.980 in cognitive, 0.965 in psycho-emotional, and 0.972 in social aspects based on the Cronbach's test of intra-item internal consistency and half reliability of Spearman-Brown. This study was the first to demonstrate validity and reliability by simultaneously developing four measures of horticultural therapy effectiveness, namely, physical, cognitive, psychological-emotional, and social, both locally and externally. It is especially worthwhile in that it can be applied in common to people. Copyright © 2018 Elsevier Ltd. All rights reserved.

A preliminary study to evaluate postural improvement in subjects with scoliosis: active therapeutic movement version 2 device and home exercises using the Mulligan's mobilization-with-movement concept.

PubMed

Lewis, Clare; Diaz, Rafael; Lopez, Geoff; Marki, Nicholas; Olivio, Ben

2014-09-01

The purpose of this preliminary study was to determine if the use of Active Therapeutic Movement Version 2 (ATM2) device and home exercises using the Mulligan's mobilization-with-movement concept by subjects with scoliosis would result in postural improvement and to document any changes in trunk range of motion and quality of life. Forty-three subjects between the ages of 12 to 75 years were recruited for the study. Each subject underwent a low back evaluation along with specific measurements for their scoliosis. Subjects participated in a 4-week intervention, 2 times a week consisting of treatment utilizing the ATM2 and were also given a home exercise program to mimic the specific movement(s) they performed on the ATM2. Photographic assessment of posture was taken before and after the intervention. Subjects were surveyed during the initial assessment and again at the final intervention using the following outcome measures: Fear Avoidance Belief Questionnaire, Short-Form Health Survey-36, Oswestry Disability Index, and a Numeric Pain Rating Scale. Results were significant for most of the variables measured. Subjects gained improvement in spinal ranges of motion for all directions except for flexion and extension (most subjects had reference range of flexion and extension at the beginning of the study). Most subjects had improved pelvic alignment after the intervention. Before and after photographs demonstrated improved posture. Subjective measurements of pain, disability, and quality of life improved. Results of this preliminary study showed improvement for selected variables. The use of ATM2 and home exercises using the Mulligan's mobilization-with-movement concept by subjects with scoliosis appears to be a potentially viable conservative treatment alternative to address various findings associated with scoliosis, including posture improvement. Copyright © 2014 National University of Health Sciences. Published by Elsevier Inc. All rights reserved.

A preliminary study of numerical simulation of thermosolutal convection of interest to crystal growth

NASA Technical Reports Server (NTRS)

Miller, T. L.

1984-01-01

Calculations were performed with computer models using three types of finite difference methods of thermosolutal convection: horizontal heating of a container filled with a stably stratified solution, finger convection in a container, and finger convection in a horizontally infinite channel. The importance of including thermosolutal convection in models of crystal growth is emphasized, and the difficulties in doing so are demonstrated. It is pointed out that these difficulties, due primarily to the fine structure of the convection, may be partly overcome by the use of fine grids and implicit time stepping methods.

General and mild Ni(0)-catalyzed α-arylation of ketones using aryl chlorides.

PubMed

Fernández-Salas, José A; Marelli, Enrico; Cordes, David B; Slawin, Alexandra M Z; Nolan, Steven P

2015-03-02

A general methodology for the α-arylation of ketones using a nickel catalyst has been developed. The new well-defined [Ni(IPr*)(cin)Cl] (1 c) pre-catalyst showed great efficiency for this transformation, allowing the coupling of a wide range of ketones, including acetophenone derivatives, with various functionalised aryl chlorides. This cinnamyl-based Ni-N-heterocyclic carbene (NHC) complex has demonstrated a different behaviour to previously reported NHC-Ni catalysts. Preliminary mechanistic studies suggest a Ni(0)/Ni(II) catalytic cycle to be at play. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Rotating and positive-displacement pumps for low-thrust rocket engines. Volume 2: Fabrication and testing

NASA Technical Reports Server (NTRS)

Csomor, A.

1974-01-01

Rotating and positive displacement pumps of various types were studied for pumping liquid fluorine for low thrust high performance rocket engines. Included in the analysis were: centrifugal, pitot, Barske, Tesla, drag, gear, vane, axial piston, radial piston, diaphragm and helirotor pump concepts. The centrifugal and gear pumps were carried through detail design and fabrication. After preliminary testing in Freon 12, the centrifugal pump was selected for further testing and development. It was tested in Freon 12 to obtain the hydrodynamic performance. Tests were also conducted in liquid fluorine to demonstrate chemical compatibility.

Comparative evaluation of the antimicrobial efficacy of aloe vera tooth gel and two popular commercial toothpastes: an in vitro study.

PubMed

George, Dilip; Bhat, Sham S; Antony, Beena

2009-01-01

Aloe vera (Aloe barbadensis Miller) has been suggested for a wide variety of ailments but its use in dentistry is limited. This article reviews the uses of the plant and describes an in vitro investigation that compared the antimicrobial effectiveness of aloe vera tooth gel with two popular, commercially available dentifrices. The preliminary results showed that aloe vera tooth gel and the toothpastes were equally effective against Candida albicans, Streptococcus mutans, Lactobacillus acidophilus, Enterococcus faecalis, Prevotella intermedia, and Peptostreptococcus anaerobius. Aloe vera tooth gel demonstrated enhanced antibacterial effect against S. mitis.

Renewable energy projects in the Dominican Republic

DOE Office of Scientific and Technical Information (OSTI.GOV)

Viani, B.

1997-12-01

This paper describes a US/Dominican Republic program to develop renewable energy projects in the country. The objective is to demonstrate the commercial viability of renewable energy generation projects, primarily small-scale wind and hydropower. Preliminary studies are completed for three micro-hydro projects with a total capacity of 262 kWe, and two small wind power projects for water pumping. In addition wind resource assessment is ongoing, and professional training and technical assistance to potential investors is ongoing. Projects goals include not less than ten small firms actively involved in installation of such systems by September 1998.

Evolutionary computing for the design search and optimization of space vehicle power subsystems

NASA Technical Reports Server (NTRS)

Kordon, Mark; Klimeck, Gerhard; Hanks, David; Hua, Hook

2004-01-01

Evolutionary computing has proven to be a straightforward and robust approach for optimizing a wide range of difficult analysis and design problems. This paper discusses the application of these techniques to an existing space vehicle power subsystem resource and performance analysis simulation in a parallel processing environment. Out preliminary results demonstrate that this approach has the potential to improve the space system trade study process by allowing engineers to statistically weight subsystem goals of mass, cost and performance then automatically size power elements based on anticipated performance of the subsystem rather than on worst-case estimates.

Determining potential 30/20 GHZ domestic satellite system concepts and establishment of a suitable experimental configuration

NASA Technical Reports Server (NTRS)

Stevens, G. H.; Anzic, G.

1979-01-01

NASA is conducting a series of millimeter wave satellite communication systems and market studies to: (1) determine potential domestic 30/20 GHz satellite concepts and market potential, and (2) establish the requirements for a suitable technology verification payload which, although intended to be modest in capacity, would sufficiently demonstrate key technologies and experimentally address key operational issues. Preliminary results and critical issues of the current contracted effort are described. Also included is a description of a NASA-developed multibeam satellite payload configuration which may be representative of concepts utilized in a technology flight verification program.

Guidelines for Computing Longitudinal Dynamic Stability Characteristics of a Subsonic Transport

NASA Technical Reports Server (NTRS)

Thompson, Joseph R.; Frank, Neal T.; Murphy, Patrick C.

2010-01-01

A systematic study is presented to guide the selection of a numerical solution strategy for URANS computation of a subsonic transport configuration undergoing simulated forced oscillation about its pitch axis. Forced oscillation is central to the prevalent wind tunnel methodology for quantifying aircraft dynamic stability derivatives from force and moment coefficients, which is the ultimate goal for the computational simulations. Extensive computations are performed that lead in key insights of the critical numerical parameters affecting solution convergence. A preliminary linear harmonic analysis is included to demonstrate the potential of extracting dynamic stability derivatives from computational solutions.

An experimental/analytical program to assess the utility of lidar for pollution monitoring

NASA Technical Reports Server (NTRS)

Mills, F. S.; Allen, R. J.; Butler, C. F.; Kindle, E. C.

1978-01-01

The development and demonstration of lidar techniques for the remote measurement of atmospheric constituents and transport processes in the lower troposphere was carried out. Particular emphasis was given to techniques for monitoring SO2 and particulates, the principal pollutants in power plant and industrial plumes. Data from a plume dispersion study conducted in Maryland during September and October 1976 were reduced, and a data base was assembled which is available to the scientific community for plume model verification. A UV Differential Absorption Lidar (DIAL) was built, and preliminary testing was done.

Automatic system for computer program documentation

NASA Technical Reports Server (NTRS)

Simmons, D. B.; Elliott, R. W.; Arseven, S.; Colunga, D.

1972-01-01

Work done on a project to design an automatic system for computer program documentation aids was made to determine what existing programs could be used effectively to document computer programs. Results of the study are included in the form of an extensive bibliography and working papers on appropriate operating systems, text editors, program editors, data structures, standards, decision tables, flowchart systems, and proprietary documentation aids. The preliminary design for an automated documentation system is also included. An actual program has been documented in detail to demonstrate the types of output that can be produced by the proposed system.

Compact regenerable sulfur scrubber for phosphoric acid fuel cells. Final report, 30 September 1986-30 September 1987

DOE Office of Scientific and Technical Information (OSTI.GOV)

Giner, J.; Cropley, C.C.

Technology for the direct desulfurization of unprocessed diesel fuel using regenerable copper-based mixed metal oxide sorbents was developed for incorporation in modular phosphoric acid fuel cell (PAFC) generators. Removal of greater 60% of the sulfur in diesel fuel was demonstrated, and sorbent sulfur loadings of approximately 1 wt% were attained. Preliminary studies indicated that the sorbents are regenerable, with up to 70% of the sorbed sulfur removed during regeneration. Incorporation of this technology into a PAFC power plant should reduce the weight of the sulfur removal unit by a minimum of 25%.

General aviation design synthesis utilizing interactive computer graphics

NASA Technical Reports Server (NTRS)

Galloway, T. L.; Smith, M. R.

1976-01-01

Interactive computer graphics is a fast growing area of computer application, due to such factors as substantial cost reductions in hardware, general availability of software, and expanded data communication networks. In addition to allowing faster and more meaningful input/output, computer graphics permits the use of data in graphic form to carry out parametric studies for configuration selection and for assessing the impact of advanced technologies on general aviation designs. The incorporation of interactive computer graphics into a NASA developed general aviation synthesis program is described, and the potential uses of the synthesis program in preliminary design are demonstrated.

Eliciting Affect via Immersive Virtual Reality: A Tool for Adolescent Risk Reduction

PubMed Central

Houck, Christopher D.; Barker, David H.; Garcia, Abbe Marrs; Spitalnick, Josh S.; Curtis, Virginia; Roye, Scott; Brown, Larry K.

2014-01-01

Objective A virtual reality environment (VRE) was designed to expose participants to substance use and sexual risk-taking cues to examine the utility of VR in eliciting adolescent physiological arousal. Methods 42 adolescents (55% male) with a mean age of 14.54 years (SD = 1.13) participated. Physiological arousal was examined through heart rate (HR), respiratory sinus arrhythmia (RSA), and self-reported somatic arousal. A within-subject design (neutral VRE, VR party, and neutral VRE) was utilized to examine changes in arousal. Results The VR party demonstrated an increase in physiological arousal relative to a neutral VRE. Examination of individual segments of the party (e.g., orientation, substance use, and sexual risk) demonstrated that HR was significantly elevated across all segments, whereas only the orientation and sexual risk segments demonstrated significant impact on RSA. Conclusions This study provides preliminary evidence that VREs can be used to generate physiological arousal in response to substance use and sexual risk cues. PMID:24365699

Extrapolating Accelerated UV Weathering Data: Perspective From PVQAT Task Group 5 (Presentation)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, D.; Annigoni, E.; Ballion, A.

2015-02-01

Taskgroup 5 (TG5) is concerned with a accelerated aging standard incorporating factors including ultraviolet radiation, temperature, and moisture. Separate experiments are being conducted in support of a test standard via the regional sub-groups in Asia, Europe, and the United States. The authors will describe the objectives and timeline for the TG5 interlaboratory study being directed out of the USA. Qualitative preliminary data from the experiment is presented. To date, the encapsulation transmittance experiment has: replicated behaviors of fielded materials (including specimen location- and formulation additive-specific discoloration); demonstrated coupling between UV aging and temperature; demonstrated that degradation in EVA results frommore » UV- aging; and obtained good qualitative comparison between Xe and UVA-340 sources for EVA. To date, the encapsulation adhesion experiment (using the compressive shear test to quantify strength of attachment) has demonstrated that attachment strength can decrease drastically (>50%) with age; however, early results suggest significant factor (UV, T, RH) dependence. Much remains to be learned about adhesion.« less

Coalition readiness management system preliminary interoperability experiment (CReaMS PIE)

NASA Astrophysics Data System (ADS)

Clark, Peter; Ryan, Peter; Zalcman, Lucien; Robbie, Andrew

2003-09-01

The United States Navy (USN) has initiated the Coalition Readiness Management System (CReaMS) Initiative to enhance coalition warfighting readiness through advancing development of a team interoperability training and combined mission rehearsal capability. It integrates evolving cognitive team learning principles and processes with advanced technology innovations to produce an effective and efficient team learning environment. The JOint Air Navy Networking Environment (JOANNE) forms the Australian component of CReaMS. The ultimate goal is to link Australian Defence simulation systems with the USN Battle Force Tactical Training (BFTT) system to demonstrate and achieve coalition level warfare training in a synthetic battlespace. This paper discusses the initial Preliminary Interoperability Experiment (PIE) involving USN and Australian Defence establishments.

Characterizing Discourse Deficits Following Penetrating Head Injury: A Preliminary Model

ERIC Educational Resources Information Center

Coelho, Carl; Le, Karen; Mozeiko, Jennifer; Hamilton, Mark; Tyler, Elizabeth; Krueger, Frank; Grafman, Jordan

2013-01-01

Purpose: Discourse analyses have demonstrated utility for delineating subtle communication deficits following closed head injuries (CHIs). The present investigation examined the discourse performance of a large group of individuals with penetrating head injury (PHI). Performance was also compared across 6 subgroups of PHI based on lesion locale. A…

Examining the Role of Multicultural Competence in Leadership Program Design

ERIC Educational Resources Information Center

Wilson, Amy B.

2015-01-01

Research examining the multicultural competence of leadership educators across a variety of institutions demonstrated variance based on leadership program structure, program elements, and the ways in which diversity was addressed in the program. The Multicultural Competence in Student Affairs-Preliminary 2 (MCSA-P2) scale was used to measure…

Aerobic Exercise for Alcohol Recovery: Rationale, Program Description, and Preliminary Findings

ERIC Educational Resources Information Center

Brown, Richard A.; Abrantes, Ana M.; Read, Jennifer P.; Marcus, Bess H.; Jakicic, John; Strong, David R.; Oakley, Julie R.; Ramsey, Susan E.; Kahler, Christopher W.; Stuart, Gregory; Dubreuil, Mary Ella; Gordon, Alan A.

2009-01-01

Alcohol use disorders are a major public health concern. Despite the demonstrated efficacy of a number of different treatments for alcohol dependence, relapse remains a major problem. Healthy lifestyle changes may contribute to long-term maintenance of recovery, and interventions targeting physical activity, in particular, may be especially…

ADVANCED COMBUSTION SYSTEMS FOR STATIONARY GAS TURBINE ENGINES: VOLUME I. REVIEW AND PRELIMINARY EVALUATION

EPA Science Inventory

The reports describe an exploratory development program to identify, evaluate, and demonstrate dry techniques for significantly reducing NOx from thermal and fuel-bound sources in stationary gas turbine engines. Volume 1 covers Phase I of the four-phase effort. In Phase I, duty c...

Tactics for the Educational Change Agent. A Preliminary Analyisis.

ERIC Educational Resources Information Center

Rosenau, Fred S.

This prototype of a guide for educational change agents focuses on the roles and tactics of personnel employed in nonprofit educational research and development organizations and in state and intermediate education agencies. Included is a compilation of reports from recent users of three classes of tactics: information, demonstration, and field…

A Preliminary Approach to Adding Indicators of Ecosystem Service Benefits to a Wetlands Functional Assessment Tool

EPA Science Inventory

State-level managers and restoration advocates have expressed a desire for approaches that address wetlands services and benefits for two purposes: to demonstrate the benefits of money budgeted for restoration, and to compare proposals when awarding restoration funds for specific...

Generational Attitudes and Teacher ICT Use

ERIC Educational Resources Information Center

Pegler, Karen; Kollewyn, Joan; Crichton, Susan

2010-01-01

This paper explores the impact of generational attitudes on teachers' ICT use. Findings from the preliminary research suggest that when applications have a use or purpose that extends beyond the classroom and into their social or personal sphere, younger teachers demonstrate noticeable confidence and a higher potential for technology integration…

Assessing and Treating Child Anxiety in Schools

ERIC Educational Resources Information Center

Mychailyszyn, Matthew P.; Beidas, Rinad S.; Benjamin, Courtney L.; Edmunds, Julie M.; Podell, Jennifer L.; Cohen, Jeremy S.; Kendall, Philip C.

2011-01-01

Anxiety disorders in youth are common and, if left untreated, can lead to a variety of negative sequelae. Randomized clinical trials have demonstrated that cognitive-behavioral therapy (CBT) is an efficacious treatment for anxiety disorders in youth with preliminary evidence showing that CBT can be successfully transported into schools. The…

Early Onset Bipolar Spectrum Disorder: Psychopharmacological, Psychological, and Educational Management

ERIC Educational Resources Information Center

McIntosh, David E.; Trotter, Jeffrey S.

2006-01-01

Although published research continues to advocate medication as the first line of treatment for early onset bipolar spectrum disorder (EOBSD; N. Lofthouse & M.A. Fristad, 2004), preliminary research demonstrating the utility of cognitive, cognitive-behavioral, and psychoeducational therapies is promising. It appears as if future treatment of EOBSD…

Lower Aerobic Endurance Linked to History of Depression in Multiple Sclerosis: Preliminary Observations.

PubMed

Chapman, Kimberly R; Anderson, Jason R; Calvo, Dayana; Pollock, Brandon S; Petersen, Jennifer; Gerhart, Hayden; Ridgel, Angela; Spitznagel, Mary Beth

2018-06-01

Despite the demonstrated benefits of exercise in multiple sclerosis (MS), this population shows low rates of physical activity. Understanding barriers to exercise in persons with MS is important. The current study examined the relationship between lifetime history of depression, current depressive symptoms, and aerobic endurance in persons with relapsing-remitting MS to determine whether depression might be one such barrier. Thirty-one participants with relapsing-remitting MS self-reported current depressive symptoms and history of depression. Aerobic endurance was assessed via 2-Minute Step Test. Linear regression demonstrated that lifetime history of depression predicted lower aerobic fitness whereas current depressive symptoms did not. Findings suggest a possible role of lifetime depression as a barrier to exercise in MS and highlight the importance of effective treatment of depression in this population to reduce its potential impact on exercise adherence.

Walking on uneven terrain with a powered ankle prosthesis: A preliminary assessment.

PubMed

Shultz, Amanda H; Lawson, Brian E; Goldfarb, Michael

2015-01-01

A successful walking gait with a powered prosthesis depends heavily on proper timing of power delivery, or push-off. This paper describes a control approach which provides improved walking on uneven terrain relative to previous work intended for use on even (level) terrain. This approach is motivated by an initial healthy subject study which demonstrated less variation in sagittal plane shank angle than sagittal plane ankle angle when walking on uneven terrain relative to even terrain. The latter therefore replaces the former as the control signal used to initiate push-off in the powered prosthesis described herein. The authors demonstrate improvement in consistency for several gait characteristics, relative to healthy, as well as controller characteristics with the new control approach, including a 50% improvement in the consistency of the percentage of stride at which push-off is initiated.

Image processing on the image with pixel noise bits removed

NASA Astrophysics Data System (ADS)

Chuang, Keh-Shih; Wu, Christine

1992-06-01

Our previous studies used statistical methods to assess the noise level in digital images of various radiological modalities. We separated the pixel data into signal bits and noise bits and demonstrated visually that the removal of the noise bits does not affect the image quality. In this paper we apply image enhancement techniques on noise-bits-removed images and demonstrate that the removal of noise bits has no effect on the image property. The image processing techniques used are gray-level look up table transformation, Sobel edge detector, and 3-D surface display. Preliminary results show no noticeable difference between original image and noise bits removed image using look up table operation and Sobel edge enhancement. There is a slight enhancement of the slicing artifact in the 3-D surface display of the noise bits removed image.

Environmental technology demonstrations involving explosives contamination at the Volunteer Site

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walker, A.J.; Broder, M.F.; Jayne, E.A.

1997-08-01

Managed by the US Army Environmental Center, the Army`s test site at Volunteer Army Ammunition Plant encompasses a 300-acre area formerly used for batch production of TNT. Soil and groundwater contamination in the test area is well characterized. A network of monitoring wells and detailed information regarding the volume, location, and concentration of soil contamination is available to potential demonstrators. On-site field and laboratory support is provided by ICI Americas Incorporated, the facility`s operator. Four demonstrations have been conducted at the test site and several are scheduled for 1997. Preliminary findings from the four demonstrations discussed will be available sometimemore » in 1997.« less

Longitudinal diffusion MRI for treatment response assessment: Preliminary experience using an MRI-guided tri-cobalt 60 radiotherapy system.

PubMed

Yang, Yingli; Cao, Minsong; Sheng, Ke; Gao, Yu; Chen, Allen; Kamrava, Mitch; Lee, Percy; Agazaryan, Nzhde; Lamb, James; Thomas, David; Low, Daniel; Hu, Peng

2016-03-01

To demonstrate the preliminary feasibility of a longitudinal diffusion magnetic resonance imaging (MRI) strategy for assessing patient response to radiotherapy at 0.35 T using an MRI-guided radiotherapy system (ViewRay). Six patients (three head and neck cancer, three sarcoma) who underwent fractionated radiotherapy were enrolled in this study. A 2D multislice spin echo single-shot echo planar imaging diffusion pulse sequence was implemented on the ViewRay system and tested in phantom studies. The same pulse sequence was used to acquire longitudinal diffusion data (every 2-5 fractions) on the six patients throughout the entire course of radiotherapy. The reproducibility of the apparent diffusion coefficient (ADC) measurements was assessed using reference regions and the temporal variations of the tumor ADC values were evaluated. In diffusion phantom studies, the ADC values measured on the ViewRay system matched well with reference ADC values with <5% error for a range of ground truth diffusion coefficients of 0.4-1.1 × 10(-3) mm(2)/s. The remote reference regions (i.e., brainstem in head and neck patients) had consistent ADC values throughout the therapy for all three head and neck patients, indicating acceptable reproducibility of the diffusion imaging sequence. The tumor ADC values changed throughout therapy, with the change differing between patients, ranging from a 40% drop in ADC within the first week of therapy to gradually increasing throughout therapy. For larger tumors, intratumoral heterogeneity was observed. For one sarcoma patient, postradiotherapy biopsy showed less than 10% necrosis score, which correlated with the observed 40% decrease in ADC from the fifth fraction to the eighth treatment fraction. This pilot study demonstrated that longitudinal diffusion MRI is feasible using the 0.35 T ViewRay MRI. Larger patient cohort studies are warranted to correlate the longitudinal diffusion measurements to patient outcomes. Such an approach may enable response-guided adaptive radiotherapy.

Pd-Catalyzed Asymmetric β-Hydride Elimination En Route to Chiral Allenes

PubMed Central

Crouch, Ian T.; Neff, Robynne K.; Frantz, Doug E.

2013-01-01

We wish to report our preliminary results on the discovery and development of a catalytic, asymmetric β-hydride elimination from vinyl Pd(II)-complexes derived from enol triflates to access chiral allenes. To achieve this, we developed a class of chiral phosphite ligands that demonstrate high enantioselectivity, allow access of either allene enantiomer, and are readily synthesized. The methodology is demonstrated on over 20 substrates and application to the formal asymmetric total synthesis of the natural product, (+)-epibatidine, is also provided. PMID:23488914

AIC Computations Using Navier-Stokes Equations on Single Image Supercomputers For Design Optimization

NASA Technical Reports Server (NTRS)

Guruswamy, Guru

2004-01-01

A procedure to accurately generate AIC using the Navier-Stokes solver including grid deformation is presented. Preliminary results show good comparisons between experiment and computed flutter boundaries for a rectangular wing. A full wing body configuration of an orbital space plane is selected for demonstration on a large number of processors. In the final paper the AIC of full wing body configuration will be computed. The scalability of the procedure on supercomputer will be demonstrated.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Greenberg, S.D.; Smith, S.; Swank, P.R.

Visual cell profiles were used to analyze the distribution of atypical bronchial cells in sputum specimens from cigarette-smoking volunteers, cigarette-smoking asbestos workers and cigarette-smoking uranium miners. The preliminary results of these sputum visual cell profile studies have demonstrated distinctive distributions of bronchial cell atypias in progressive patterns of squamous metaplasia, mild, moderate and severe atypias and carcinoma, similar to those the authors have previously reported using cell image analysis techniques to determine an atypia status index (ASI). The information gained from this study will be helpful in further validating this ASI and subsequently achieving the ultimate goal of employing cellmore » image analysis for the rapid and precise identification of premalignant atypias in sputum.« less

β-Decay Studies of r-Process Nuclei Using the Advanced Implantation Detector Array (AIDA)

NASA Astrophysics Data System (ADS)

Griffin, C. J.; Davinson, T.; Estrade, A.; Braga, D.; Burrows, I.; Coleman-Smith, P. J.; Grahn, T.; Grant, A.; Harkness-Brennan, L. J.; Kiss, G.; Kogimtzis, M.; Lazarus, I. H.; Letts, S. C.; Liu, Z.; Lorusso, G.; Matsui, K.; Nishimura, S.; Page, R. D.; Prydderch, M.; Phong, V. H.; Pucknell, V. F. E.; Rinta-Antila, S.; Roberts, O. J.; Seddon, D. A.; Simpson, J.; Thomas, S. L.; Woods, P. J.

Thought to produce around half of all isotopes heavier than iron, the r-process is a key mechanism for nucleosynthesis. However, a complete description of the r-process is still lacking and many unknowns remain. Experimental determination of β-decay half-lives and β-delayed neutron emission probabilities along the r-process path would help to facilitate a greater understanding of this process. The Advanced Implantation Detector Array (AIDA) represents the latest generation of silicon implantation detectors for β-decay studies with fast radioactive ion beams. Preliminary results from commissioning experiments demonstrate successful operation of AIDA and analysis of the data obtained during the first official AIDA experiments is now under-way.

Preparation, Characterization, and Preliminary In Vitro Testing of Nanoceria-Loaded Liposomes

PubMed Central

Grillone, Agostina; Li, Tianshu; Battaglini, Matteo; Scarpellini, Alice; Takeoka, Shinji

2017-01-01

Cerium oxide nanoparticles (nanoceria), well known for their pro- and antioxidant features, have been recently proposed for the treatment of several pathologies, including cancer and neurodegenerative diseases. However, interaction between nanoceria and biological molecules such as proteins and lipids, short blood circulation time, and the need of a targeted delivery to desired sites are some aspects that require strong attention for further progresses in the clinical application of these nanoparticles. The aim of this work is the encapsulation of nanoceria into a liposomal formulation in order to improve their therapeutic potentialities. After the preparation through a reverse-phase evaporation method, size, Z-potential, morphology, and loading efficiency of nanoceria-loaded liposomes were investigated. Finally, preliminary in vitro studies were performed to test cell uptake efficiency and preserved antioxidant activity. Nanoceria-loaded liposomes showed a good colloidal stability, an excellent biocompatibility, and strong antioxidant properties due to the unaltered activity of the entrapped nanoceria. With these results, the possibility of exploiting liposomes as carriers for cerium oxide nanoparticles is demonstrated here for the first time, thus opening exciting new opportunities for in vivo applications. PMID:28926967

DOE Office of Scientific and Technical Information (OSTI.GOV)

Apte, Michael G.; Buchanan, Ian S.; Faulkner, David

The primary goals of this research effort are to develop, evaluate, and demonstrate a very practical HVAC system for classrooms that consistently provides classrooms with the quantity of ventilation in current minimum standards, while saving energy, and reducing HVAC-related noise levels. This research is motivated by the public benefits of energy efficiency, evidence that many classrooms are under-ventilated, and public concerns about indoor environmental quality in classrooms. This report presents an interim status update and preliminary findings from energy and indoor environmental quality (IEQ) measurements in sixteen relocatable classrooms in California. The field study includes measurements of HVAC energy use,more » ventilation rates, and IEQ conditions. Ten of the classrooms were equipped with a new HVAC technology and six control classrooms were equipped with a standard HVAC system. Energy use and many IEQ parameters have been monitored continuously, while unoccupied acoustic measurements were measured in one of four planned seasonal measurement campaigns. Continuously monitored data are remotely accessed via a LonWorks{reg_sign} network and stored in a relational database at LBNL. Preliminary results are presented here.« less

Paediatric x-ray radiation dose reduction and image quality analysis.

PubMed

Martin, L; Ruddlesden, R; Makepeace, C; Robinson, L; Mistry, T; Starritt, H

2013-09-01

Collaboration of multiple staff groups has resulted in significant reduction in the risk of radiation-induced cancer from radiographic x-ray exposure during childhood. In this study at an acute NHS hospital trust, a preliminary audit identified initial exposure factors. These were compared with European and UK guidance, leading to the introduction of new factors that were in compliance with European guidance on x-ray tube potentials. Image quality was assessed using standard anatomical criteria scoring, and visual grading characteristics analysis assessed the impact on image quality of changes in exposure factors. This analysis determined the acceptability of gradual radiation dose reduction below the European and UK guidance levels. Chest and pelvis exposures were optimised, achieving dose reduction for each age group, with 7%-55% decrease in critical organ dose. Clinicians confirmed diagnostic image quality throughout the iterative process. Analysis of images acquired with preliminary and final exposure factors indicated an average visual grading analysis result of 0.5, demonstrating equivalent image quality. The optimisation process and final radiation doses are reported for Carestream computed radiography to aid other hospitals in minimising radiation risks to children.

Work It Out Together: Preliminary Efficacy of a Parent and Adolescent DVD and Workbook Intervention on Adolescent Sexual and Substance Use Attitudes and Parenting Behaviors.

PubMed

Hadley, Wendy; Brown, L K; Barker, D; Warren, J; Weddington, P; Fortune, T; Juzang, I

2016-09-01

The purpose of the current study was to test an interactive DVD and workbook specifically designed for African-American parents and adolescents (ages 13-18), based on an efficacious face-to-face intervention, to address key factors associated with risk. A total of 170 parent-adolescent dyads were enrolled and randomly assigned to receive either the "Work It Out Together" DVD or a General Health Promotion DVD (HP). Parents and adolescents completed measures of HIV knowledge, self-efficacy, and parenting behaviors. Immediately after receiving the Work It Out Together intervention, parents and adolescents demonstrated higher HIV knowledge and greater HIV prevention self-efficacy. Three months after receiving the Work It Out Together intervention, parents and adolescents reported higher levels of parental monitoring and sexually active adolescents reported higher levels of condom use self-efficacy and a lower rate of recent sex. These outcomes provide preliminary evidence that the "Work It Out Together" DVD impacted individual attitudes and protective parenting behaviors.

A Preliminary RCT of CBT-AD for Adherence and Depression among HIV-Positive Latinos on the U.S. –Mexico Border: The Nuevo Día Study

PubMed Central

Simoni, Jane M.; Wiebe, John S.; Sauceda, John A.; Huh, David; Sanchez, Giselle; Longoria, Virginia; Bedoya, C. Andres; Safren, Steven A.

2013-01-01

We conducted a preliminary RCT among 40 HIV-positive Latinos of Mexican descent on the U.S.-Mexico border who indicated imperfect adherence and depressive symptomatology. Participants were randomly assigned to culturally adapted cognitive-behavioral therapy for adherence and depression (CBT-AD) with an alarmed pillbox or usual care. Outcomes were depressive symptoms (self-report and blind clinician ratings), adherence (self-report and electronic pillbox), and biological markers. The intervention, delivered in English and Spanish, proved feasible and acceptable. Generalized estimating equations in intent-to-treat analyses showed some effects of “moderate” to “large” size, with maintenance over time. For example, intervention (vs. control) participants demonstrated at post-intervention a greater drop in BDI scores (OR = - 3.64, p = .05) and greater adherence according to the electronic pillbox (OR = 3.78, p = .03). Biological markers indicated some relative improvement for CD4 count but not VL. The promising results suggest a larger trial to determine efficacy is warranted. PMID:23812892

High-temperature catalytically assisted combustion. Final report, 1 August 1981-31 July 1983

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bracco, F.V.; Royce, B.S.H.; Santavicca, D.A.

1983-07-31

Results of research on a two-dimensional, transient catalytic combustion model and on a high temperature perovskite catalyst are presented. A recently developed two-dimensional, transient model was used to study the ignition of carbon monoxide/air mixtures in a platinum-coated catalytic honeycomb. Comparisons between calculated and measured steady-state substrate temperature profiles and exhaust-gas compositions show good agreement. A platinum-doped perovskite catalyst proposed will exhibit low-temperature light off and high-temperature stability. Preliminary tests using a perovskite powder with 1 wt.% platinium are encouraging, showing very little change in surface activity when used with propane fuel. Variations in catalytic activity from sample to samplemore » were also found, and after extensive testing the cause of these variations could not be identified. However, preliminary tests using Fourier-transform infrared photoacoustic spectroscopy do indicate differences in the various catalyst samples that may be related to the difference in catalytic activity. The use of bench-top-oven and differential-scanning-calorimetry techniques for screening catalysts in terms of relative activity and aging characteristics were also demonstrated.« less

Investigation of the effects of the macrophysical and microphysical properties of cirrus clouds on the retrieval of optical properties: Results for FIRE 2

NASA Technical Reports Server (NTRS)

Stackhouse, Paul W., Jr.; Stephens, Graeme L.

1993-01-01

Due to the prevalence and persistence of cirrus cloudiness across the globe, cirrus clouds are believed to have an important effect on the climate. Stephens et al., (1990) among others have shown that the important factor determining how cirrus clouds modulate the climate is the balance between the albedo and emittance effect of the cloud systems. This factor was shown to depend in part upon the effective sizes of the cirrus cloud particles. Since effective sizes of cirrus cloud microphysical distributions are used as a basis of parameterizations in climate models, it is crucial that the relationships between effective sizes and radiative properties be clearly established. In this preliminary study, the retrieval of cirrus cloud effective sizes are examined using a two dimensional radiative transfer model for a cirrus cloud case sampled during FIRE Cirrus 11. The purpose of this paper is to present preliminary results from the SHSG model demonstrating the sensitivity of the bispectral relationships of reflected radiances and thus the retrieval of effective sizes to phase function and dimensionality.

Transoral robotic surgery for the base of tongue squamous cell carcinoma: a preliminary comparison between da Vinci Xi and Si.

PubMed

Alessandrini, Marco; Pavone, Isabella; Micarelli, Alessandro; Caporale, Claudio

2017-09-13

Considering the emerging advantages related to da Vinci Xi robotic platform, the aim of this study is to compare for the first time the operative outcomes of this tool to the previous da Vinci Si during transoral robotic surgery (TORS), both performed for squamous cell carcinomas (SCC) of the base of tongue (BOT). Intra- and peri-operative outcomes of eight patients with early stage (T1-T2) of the BOT carcinoma and undergoing TORS by means of the da Vinci Xi robotic platform (Xi-TORS) are compared with the da Vinci Si group ones (Si-TORS). With respect to Si-TORS group, Xi-TORS group demonstrated a significantly shorter overall operative time, console time, and intraoperative blood loss, as well as peri-operative pain intensity and length of mean hospital stays and nasogastric tube positioning. Considering recent advantages offered by surgical robotic techniques, the da Vinci Xi Surgical System preliminary outcomes could suggest its possible future routine implementation in BOT squamous cell carcinoma procedures.

Work It Out Together: Preliminary Efficacy of a Parent and Adolescent DVD and Workbook Intervention on Adolescent Sexual and Substance Use Attitudes and Parenting Behaviors

PubMed Central

Brown, L. K.; Barker, D.; Warren, J.; Weddington, P.; Fortune, T.; Juzang, I.

2016-01-01

The purpose of the current study was to test an interactive DVD and workbook specifically designed for African-American parents and adolescents (ages 13–18), based on an efficacious face-to-face intervention, to address key factors associated with risk. A total of 170 parent-adolescent dyads were enrolled and randomly assigned to receive either the “Work It Out Together” DVD or a General Health Promotion DVD (HP). Parents and adolescents completed measures of HIV knowledge, self-efficacy, and parenting behaviors. Immediately after receiving the Work It Out Together intervention, parents and adolescents demonstrated higher HIV knowledge and greater HIV prevention self-efficacy. Three months after receiving the Work It Out Together intervention, parents and adolescents reported higher levels of parental monitoring and sexually active adolescents reported higher levels of condom use self-efficacy and a lower rate of recent sex. These outcomes provide preliminary evidence that the “Work It Out Together” DVD impacted individual attitudes and protective parenting behaviors. PMID:27155880

Music and academic performance.

PubMed

Arnaud Cabanac; Perlovsky, Leonid; Bonniot-Cabanac, Marie-Claude; Cabanac, Michel

2013-11-01

In a previous study we demonstrated that listening to a pleasant music while performing an academic test helped students to overcome stress, to devote more time to more stressful and more complicated task and the grades were higher. Yet, there remained ambiguities as for the causes of the higher test performance of these students: do they perform better because they hear music during their examinations, or would they perform better anyway because they are more gifted/motivated? This motivated the current study as a preliminary step toward that general question: Do students who like/perform music have better grades than the others? Our results confirmed this hypothesis: students studying music have better grades in all subjects. Copyright © 2013 Elsevier B.V. All rights reserved.

Analysis of A549 cell proteome alteration in response to recombinant influenza A virus nucleoprotein and its interaction with cellular proteins, a preliminary study.

PubMed

Kumar, D; Tiwari, K; Rajala, M S

Influenza A virus undergoes frequent changes of antigenicity and contributes to seasonal epidemics or unpredictable pandemics. Nucleoprotein, encoded by gene segment 5, is an internal protein of the virus and is conserved among strains of different host origins. In the current study, we analyzed the differentially expressed proteins in A549 cells transiently transfected with the recombinant nucleoprotein of influenza A virus by 2D gel electrophoresis. The resolved protein spots on gel were identified by MALDI-TOF/Mass spectrometry analysis. The majority of the host proteins detected to be differentially abundant in recombinant nucleoprotein-expressing cells as compared to vector-transfected cells are the proteins of metabolic pathways, glycolytic enzymes, molecular chaperones and cytoskeletal proteins. We further demonstrated the interaction of virus nucleoprotein with some of the identified host cellular proteins. In vitro binding assay carried out using the purified recombinant nucleoprotein (pET29a+NP-His) and A549 cell lysate confirmed the interaction between nucleoprotein and host proteins, such as alpha enolase 1, pyruvate kinase and β-actin. The preliminary data of our study provides the information on virus nucleoprotein interaction with proteins involved in glycolysis. However, studies are ongoing to understand the significance of these interactions in modulating the host factors during virus replication.

A Novel Acousto-Electric Levitator for Studies of Drop and Particle Clusters and Arrays

NASA Technical Reports Server (NTRS)

Tian, Yuren; Apfel, Robert E.; Zheng, Yibing

1999-01-01

A novel and compact instrumentation for studying the behavior of drop sprays and of clusters of drops now permits fundamental research into the behavior of reacting and non-reacting fluid and solid species. The new capability is made possible by simultaneous acousto-electric levitation and charging of "seed" droplets (10-30 microns in diameter) which come together in 2-D clusters (with up to 300 droplets). These clusters are interesting in their own right because of their crystalline and quasi-crystalline forms, which depend on the acoustic and electric field parameters. By varying the electric and acoustic field intensities, one can cause a cluster of droplets to condense into larger drops (e.g. 50-300 microns) which, because of their charge, form uniformly spaced 2-D arrays of monodispersed drops (e.g. 30-40 array drops in preliminary experiments). One or more layers of these 2-D arrays can form in the acoustic standing wave. Such a configuration permits a wide range of fundamental studies of drop evaporation, combustion, and nucleation. The drops can be single or multicomponent. Therefore, fundamental materials studies can also be performed. Using this same Cluster and Array Generation (CAG) instrumentation, it has been also possible in preliminary experiments to demonstrate the clustering and arraying of solid particles, both coated with an electrically conducting layer and uncoated, and both charged and uncharged.

Distribution of methyl tert-butyl ether (MTBE) and selected water-quality constituents in the surficial aquifer at the Dover National Test Site, Dover Air Force Base, Delaware, 2001

USGS Publications Warehouse

Stewart, Marie; Guertal, William R.; Barbaro, Jeffrey R.; McHale, Timothy J.

2004-01-01

A joint study by the Dover National Test Site, Dover Air Force Base, Delaware, and the U.S. Geological Survey was conducted from June 27 through July 18, 2001, to determine the spatial distribution of the gasoline oxygenate additive methyl tert-butyl ether and selected water-quality constituents in the surficial aquifer underlying the Dover National Test Site. This report provides a summary assessment of the distribution of methyl tert-butyl ether and a preliminary screening of selected constituents that may affect natural attenuation and remediation demonstrations at the Dover National Test Site. The information gathered during this study is designed to assist potential remedial investigators who are considering conducting a methyl tert-butyl ether remedial demonstration at the test site. In addition, the study supported a planned enhanced bioremediation demonstration and assisted the Dover National Test Site in identifying possible locations for future methyl tert-butyl ether remediation demonstrations. A direct-push drill rig was used to collect a total of 147 ground-water samples (115 VOC samples and 32 quality-assurance samples) at varying depths. Volatile organic compounds were above the method reporting limits in 59 of the 115 ground-water samples. The concentrations ranged from below detection limits to maximum values of 12.4 micrograms per liter of cis-1,2-dichloro-ethene, 1.14 micrograms per liter of trichloro-ethene, 2.65 micrograms per liter of tetrachloro-ethene, 1,070 micrograms per liter of methyl tert-butyl ether, 4.36 micrograms per liter of benzene, and 1.8 micrograms per liter of toluene. Vinyl chloride, ethylbenzene, p,m-xylene, and o-xylene were not detected in any of the samples collected during this investigation. Methyl tert-butyl ether was detected in 47 of the 115 ground-water samples. The highest concentrations of methyl tert-butyl ether were detected in the surficial aquifer from ?4.6 to 6.4 feet mean sea level; however, methyl tert-butyl ether was detected as deep as ?9.5 feet mean sea level. Increased methane concentrations and decreased dissolved oxygen concentrations that were found in association with the ground-water samples that contained methyl tert-butyl ether are preliminary indicators that will assist in determining if natural attenuation of methyl tert-butyl ether is occurring in the surficial aquifer. A full assessment of natural attenuation of methyl tert-butyl ether at the site is beyond the scope of this study, but the data collected during the study will be useful in selecting appropriate remedial methyl tert-butyl ether demonstrations.

High Pressure Reverse Flow APS Engine

NASA Technical Reports Server (NTRS)

Senneff, J. M.

1972-01-01

A design and test demonstration effort was undertaken to evaluate the concept of the reverse flow engine for the APS engine application. The 1500 lb (6672 N) thrust engine was designed to operate on gaseous hydrogen and gaseous oxygen propellants at a mixture ratio of 4 and to achieve the objective performance of 435 sec (4266 Nsec/kg) specific impulse. Superimposed durability requirements called for a million-cycle capability with 50 hours duration. The program was undertaken as a series of tasks including the initial preliminary design, design of critical test components and finally, the design and demonstration of an altitude engine which could be used interchangeably to examine operating parameters as well as to demonstrate the capability of the concept. The program results are reported with data to indicate that all of the program objectives were met or exceeded within the course of testing on the program. The analysis effort undertaken is also reported in detail and supplemented with test data in some cases where prior definitions could not be made. The results are contained of these analyses as well as the test results conducted throughout the course of the program. Finally, the test data and analytical results were combined to allow recommendations for a flight weight design. This preliminary design effort is also detailed.

A preliminary investigation into the use of Red Pine (Pinus Resinosa) tree cores as historic passive samplers of POPs in outdoor air

NASA Astrophysics Data System (ADS)

Rauert, Cassandra; Harner, Tom

2016-09-01

The suitability of Red Pine trees (Pinus Resinosa) to act as passive samplers for persistent organic pollutants (POPs) in outdoor air and to provide historic information on air concentration trends was demonstrated in this preliminary investigation. Red Pine tree cores from Toronto, Canada, were tested for polycyclic aromatic hydrocarbon (PAHs), alkylated-PAHs, nitro and oxy-PAHs, polybrominated diphenyl ethers (PBDEs) and novel brominated flame retardants (novel BFRs). The PBDEs and novel BFRs demonstrated a similar relative contribution in cores representing 30 years of tree growth, to that reported in contemporary air samples. Analysis of tree ring segments of 5-15 years resulted in detectable concentrations of some PAHs and alk-PAHs and demonstrated a transition from petrogenic sources to pyrogenic sources over the period 1960-2015. A simple uptake model was developed that treats the tree rings as linear-phase passive air samplers. The bark infiltration factor, IFBARK, is a key parameter of the model that reflects the permeability of the bark to allow chemicals to be transferred from ambient air to the outer tree layer (cambium). An IFBARK of about 2% was derived for the Red Pine trees based on tree core and air monitoring data.

Preliminary GN&C Design for the On-Orbit Autonomous Assembly of Nanosatellite Demonstration Mission

NASA Technical Reports Server (NTRS)

Pei, Jing; Walsh, Matt; Roithmayr, Carlos; Karlgaard, Chris; Peck, Mason; Murchison, Luke

2017-01-01

Small spacecraft autonomous rendezvous and docking (ARD) is an essential technology for future space structure assembly missions. The On-orbit Autonomous Assembly of Nanosatellites (OAAN) team at NASA Langley Research Center (LaRC) intends to demonstrate the technology to autonomously dock two nanosatellites to form an integrated system. The team has developed a novel magnetic capture and latching mechanism that allows for docking of two CubeSats without precise sensors and actuators. The proposed magnetic docking hardware not only provides the means to latch the CubeSats, but it also significantly increases the likelihood of successful docking in the presence of relative attitude and position errors. The simplicity of the design allows it to be implemented on many CubeSat rendezvous missions. Prior to demonstrating the docking subsystem capabilities on orbit, the GN&C subsystem should have a robust design such that it is capable of bringing the CubeSats from an arbitrary initial separation distance of as many as a few thousand kilometers down to a few meters. The main OAAN Mission can be separated into the following phases: 1) Launch, checkout, and drift, 2) Far-Field Rendezvous or Drift Recovery, 3) Proximity Operations, 4) Docking. This paper discusses the preliminary GN&C design and simulation results for each phase of the mission.

Genetically modified porcine split-thickness skin grafts as an alternative to allograft for provision of temporary wound coverage: preliminary characterization.

PubMed

Leto Barone, Angelo A; Mastroianni, Melissa; Farkash, Evan A; Mallard, Christopher; Albritton, Alexander; Torabi, Radbeh; Leonard, David A; Kurtz, Josef M; Sachs, David H; Cetrulo, Curtis L

2015-05-01

Temporary coverage of severely burned patients with cadaver allograft skin represents an important component of burn care, but is limited by availability and cost. Porcine skin shares many physical properties with human skin, but is susceptible to hyperacute rejection due to preformed antibodies to α-1,3-galactose (Gal), a carbohydrate on all porcine cells. Our preliminary studies have suggested that skin grafts from α-1,3-galactosyltransferase knock out (GalT-KO) miniature swine might provide temporary wound coverage comparable to allografts, since GalT-KO swine lack this carbohydrate. To further evaluate this possibility, eight non-human primates received primary autologous, allogeneic, GalT-KO, and GalT+xenogeneic skin grafts. Additionally, secondary grafts were placed to assess whether sensitization would affect the rejection time course of identical-type grafts. We demonstrate that both GalT-KO xenografts and allografts provide temporary coverage of partial- and full-thickness wounds for up to 11 days. In contrast, GalT+xenografts displayed hyperacute rejection, with no signs of vascularization and rapid avulsion from wounds. Furthermore, secondary GalT-KO transplants failed to vascularize, demonstrating that primary graft rejection sensitizes the recipient. We conclude that GalT-KO xenografts may provide temporary coverage of wounds for a duration equivalent to allografts, and thus, could serve as a readily available alternative treatment of severe burns. Copyright © 2014 Elsevier Ltd and ISBI. All rights reserved.

Entry descent and landing systems for small planetary missions: Parametric comparison of parachutes and inflatable systems for the proposed Vanguard Mars mission

NASA Astrophysics Data System (ADS)

Allouis, E.; Ellery, A.; Welch, C. S.

2006-10-01

Here, the feasibility of a post-Beagle2 robotic Mars mission of modest size, mass and cost with a high scientific return is assessed. Based on a triad of robotics comprising a lander, a rover and three penetrating moles, the mission is astrobiology focussed, but also provides a platform for technology demonstration. The study is investigating two Entry, Descent and Landing Systems (EDLS) for the 120 kg—mission based on the conventional heatshield/parachute duo and on the use of inflatable technologies as demonstrated by the IRDT/IRDT2 projects. Moreover, to make use of existing aerodynamic databases, both EDLS are considered with two geometries: the Mars pathfinder (MPF) and Huygens/Beagle2 (B2) configurations. A versatile EDL model has been developed to provide a preliminary sizing for the different EDL systems such as heatshield, parachute, and inflatables for small to medium planetary missions. With a landed mass of 65 kg, a preliminary mass is derived for each system of the mission to provide a terminal velocity compatible with the use of airbags. On both conventional and inflatable options, the MPF configuration performs slightly better mass-wise since its cone half-angle is flatter at 70. Overall, the inflatable braking device (IBD) option performs better than the conventional one and would provide in this particular case a decrease in mass of the EDLS of about 15 18% that can be redistributed to the payload.

Entry Descent and Landing Systems for small planetary missions: parametric comparison of parachutes and inflatable systems for the proposed Vanguard Mars mission

NASA Astrophysics Data System (ADS)

Allouis, E.; Ellery, A.; Welch, C. S.

2003-11-01

Here the feasibility of a post-Beagle2 robotic Mars mission of modest size, mass and cost with a high scientific return is assessed. Based on a triad of robotics comprising a lander, a rover and three penetrating moles, the mission is astrobiology focussed, but also provides a platform for technology demonstration. The study is investigating two Entry, Descent and Landing Systems (EDLS) for the 120kg - mission based on the conventional heatshield/parachute duo and on the use of inflatable technologies as demonstrated by the IRDT/IRDT2 projects. Moreover, to make use of existing aerodynamic databases, both EDLS are considered with two geometries: the Mars Pathfinder (MPF) and Huygens/Beagle2 (B2) configurations. A versatile EDL model has been developed to provide a preliminary sizing for the different EDL systems such as heatshield, parachute, and inflatables for small to medium planetary missions. With a landed mass of 65 kg, a preliminary mass is derived for each system of the mission to provide a terminal velocity compatible with the use of airbags. On both conventional and inflatable options, the MPF configuration performs slightly better mass-wise since its cone half-angle is flatter at 70 degrees. Overall, the Inflatable Braking Device (IBD) option performs better than the conventional one and would provide in this particular case a decrease in mass of the EDLS of about 15-18% that can be redistributed to the payload.

A preliminary 6-month prospective study examining self-reported religious preference, religiosity/spirituality, and retention at a Jewish residential treatment center for substance-related disorders.

PubMed

Parhami, Iman; Davtian, Margarit; Collard, Michael; Lopez, Jean; Fong, Timothy W

2014-07-01

Although there is a substantial amount of research suggesting that higher levels of religiosity/spirituality (R/S) are associated with better treatment outcomes of substance-related disorders, no studies have explored this relationship at a faith-based residential treatment center. The objective of this prospective study is to explore the relationship between R/S, self-reported religious preference, and retention at a Jewish residential treatment center for substance-related disorders. Using the Daily Spiritual Experience Scale, R/S levels were assessed for 33 subjects at baseline, 1 month, 3 months, and 6 months. Results demonstrated a significant relationship between baseline R/S level and retention at 6 months, while R/S levels were unchanged during the course of treatment. Notably, no relationship was found between self-reported religious affiliation and retention. This study demonstrates that patients' R/S level, rather than religious affiliation, is a possible predictor for better outcome at faith-based residential centers for substance-related disorders.

A Preliminary 6-Month Prospective Study Examining Self-reported Religious Preference, Religiosity/Spirituality, and Retention at a Jewish Residential Treatment Center for Substance-Related Disorders

PubMed Central

Davtian, Margarit; Collard, Michael; Lopez, Jean; Fong, Timothy W.

2012-01-01

Although there is a substantial amount of research suggesting that higher levels of religiosity/spirituality (R/S) are associated with better treatment outcomes of substance-related disorders, no studies have explored this relationship at a faith-based residential treatment center. The objective of this prospective study is to explore the relationship between R/S, self-reported religious preference, and retention at a Jewish residential treatment center for substance-related disorders. Using the Daily Spiritual Experience Scale, R/S levels were assessed for 33 subjects at baseline, 1 month, 3 months, and 6 months. Results demonstrated a significant relationship between baseline R/S level and retention at 6 months, while R/S levels were unchanged during the course of treatment. Notably, no relationship was found between self-reported religious affiliation and retention. This study demonstrates that patients’ R/S level, rather than religious affiliation, is a possible predictor for better outcome at faith-based residential centers for substance-related disorders. PMID:22460083

Class B Alkaline Stabilization to Achieve Pathogen Inactivation

PubMed Central

Bean, Christine L.; Hansen, Jacqueline J.; Margolin, Aaron B.; Balkin, Helene; Batzer, Glenda; Widmer, Giovanni

2007-01-01

Liming is a cost-effective treatment currently employed in many Class B biosolids production plants in the United States. A bench scale model of lime stabilization was designed to evaluate the persistence of viral, bacterial and parasitic pathogens. The survival of fecal coliforms, Salmonella, adenovirus type 5, rotavirus Wa, bacteriophage MS-2, Cryptosporidium parvum oocysts, Giardia lamblia cysts, and Ascaris lumbricoides ova was evaluated under lime stabilization conditions in a water matrix. Fecal coliforms and Salmonella were undetectable following 2 hours of lime stabilization, demonstrating a 7-log reduction. Adenovirus, MS-2 and rotavirus were below detectable levels following 2 h of liming, demonstrating a 4-log reduction. G. lamblia cysts were also inactivated. A. lumbricoides ova remained viable following 72 hours of liming as did C. parvum oocysts. While this study confirmed that Ascaris ova are resistant to liming, their scarcity in sludge and low recovery efficiencies limit their use as indicator. The persistence of C. parvum oocysts after exposure to lime, suggests that this parasite would be a better choice as indicator for evaluating biosolids intended for land application. The studies done with adenovirus Type 5, rotavirus Wa and male specific bacteriophage provided preliminary data demonstrating similar inactivation rates. Monitoring anthropogenic viruses is a time consuming, labor intensive and expensive process. If further studies could demonstrate that phage could be used as an indicator of other enteric viruses, enhanced monitoring could result in greater acceptance of land application of biosolids while demonstrating no increased public health threat. PMID:17431316

BATMAN: a DMD-based MOS demonstrator on Galileo Telescope

NASA Astrophysics Data System (ADS)

Zamkotsian, Frédéric; Spanò, Paolo; Bon, William; Riva, Marco; Lanzoni, Patrick; Nicastro, Luciano; Molinari, Emilio; Cosentino, Rosario; Ghedina, Adriano; Gonzalez, Manuel; Di Marcantonio, Paolo; Coretti, Igor; Cirami, Roberto; Manetta, Marco; Zerbi, Filippo; Tresoldi, Daniela; Valenziano, Luca

2012-09-01

Multi-Object Spectrographs (MOS) are the major instruments for studying primary galaxies and remote and faint objects. Current object selection systems are limited and/or difficult to implement in next generation MOS for space and groundbased telescopes. A promising solution is the use of MOEMS devices such as micromirror arrays which allow the remote control of the multi-slit configuration in real time. We are developing a Digital Micromirror Device (DMD) - based spectrograph demonstrator called BATMAN. We want to access the largest FOV with the highest contrast. The selected component is a DMD chip from Texas Instruments in 2048 x 1080 mirrors format, with a pitch of 13.68μm. Our optical design is an all-reflective spectrograph design with F/4 on the DMD component. This demonstrator permits the study of key parameters such as throughput, contrast and ability to remove unwanted sources in the FOV (background, spoiler sources), PSF effect, new observational modes. This study will be conducted in the visible with possible extension in the IR. A breadboard on an optical bench, ROBIN, has been developed for a preliminary determination of these parameters. The demonstrator on the sky is then of prime importance for characterizing the actual performance of this new family of instruments, as well as investigating the operational procedures on astronomical objects. BATMAN will be placed on the Nasmyth focus of Telescopio Nazionale Galileo (TNG) during next year.

Development and preliminary evaluation of an integrated treatment targeting parenting and depressive symptoms in mothers of children with attention-deficit/hyperactivity disorder.

PubMed

Chronis-Tuscano, Andrea; Clarke, Tana L; O'Brien, Kelly A; Raggi, Veronica L; Diaz, Yamalis; Mintz, Abigail D; Rooney, Mary E; Knight, Laura A; Seymour, Karen E; Thomas, Sharon R; Seeley, John; Kosty, Derek; Lewinsohn, Peter

2013-10-01

More than 50% of mothers of children with attention-deficit/hyperactivity disorder (ADHD) have a lifetime history of major depressive disorder (MDD). Maternal depressive symptoms are associated with impaired parenting and predict adverse developmental and treatment outcomes for children with ADHD. For these reasons, we developed and examined the preliminary efficacy of an integrated treatment targeting parenting and depressive symptoms for mothers of children with ADHD. This integrated intervention incorporated elements of 2 evidence-based treatments: behavioral parent training (BPT) and cognitive behavioral depression treatment. Ninety-eight mothers with at least mild depressive symptoms were randomized to receive either standard BPT (n = 51) or the integrated parenting intervention for ADHD (IPI-A; n = 47). Participants were assessed at baseline, posttreatment, and 3- to 6-month follow-up on measures of (a) self-reported maternal depressive symptoms, (b) observed positive and negative parenting, and (c) observed and mother-reported child disruptive behavior and mother-reported child and family impairment. The IPI-A produced effects of small to moderate magnitude relative to BPT on maternal depressive symptoms, observed negative parenting, observed child deviance, and child impairment at posttreatment and on maternal depressive symptoms, child disruptive behavior, child impairment and family functioning at follow-up. Contrary to expectations, the BPT group demonstrated moderate to large effects relative to IPI-A on observed positive parenting at follow-up. This treatment development study provides encouraging preliminary support for the integrated intervention targeting parenting and depressive symptoms in mothers of children with ADHD. Future studies should examine whether this integrated intervention improves long-term developmental outcomes for children with ADHD. (PsycINFO Database Record (c) 2013 APA, all rights reserved).

Effects of an Off-Axis Pivoting Elliptical Training Program on Gait Function in Persons With Spastic Cerebral Palsy: A Preliminary Study.

PubMed

Tsai, Liang-Ching; Ren, Yupeng; Gaebler-Spira, Deborah J; Revivo, Gadi A; Zhang, Li-Qun

2017-07-01

This preliminary study examined the effects of off-axis elliptical training on reducing transverse-plane gait deviations and improving gait function in 8 individuals with cerebral palsy (CP) (15.5 ± 4.1 years) who completed an training program using a custom-made elliptical trainer that allows transverse-plane pivoting of the footplates during exercise. Lower-extremity off-axis control during elliptical exercise was evaluated by quantifying the root-mean-square and maximal angular displacement of the footplate pivoting angle. Lower-extremity pivoting strength was assessed. Gait function and balance were evaluated using 10-m walk test, 6-minute-walk test, and Pediatric Balance Scale. Toe-in angles during gait were quantified. Participants with CP demonstrated a significant decrease in the pivoting angle (root mean square and maximal angular displacement; effect size, 1.00-2.00) and increase in the lower-extremity pivoting strength (effect size = 0.91-1.09) after training. Reduced 10-m walk test time (11.9 ± 3.7 seconds vs. 10.8 ± 3.0 seconds; P = 0.004; effect size = 1.46), increased Pediatric Balance Scale score (43.6 ± 12.9 vs. 45.6 ± 10.8; P = 0.042; effect size = 0.79), and decreased toe-in angle (3.7 ± 10.5 degrees vs. 0.7 ± 11.7 degrees; P = 0.011; effect size = 1.22) were observed after training. We present an intervention to challenge lower-extremity off-axis control during a weight-bearing and functional activity for individuals with CP. Our preliminary findings suggest that this intervention was effective in enhancing off-axis control, gait function, and balance and reducing in-toeing gait in persons with CP.

Determining the feasibility and preliminary efficacy of a stroke instructional and educational DVD in a multinational context: a randomized controlled pilot study.

PubMed

Jones, Kelly M; Bhattacharjee, Rohit; Krishnamurthi, Rita; Blanton, Sarah; Barker-Collo, Suzanne; Theadom, Alice; Thrift, Amanda G; Wolf, Steven L; Venketasubramanian, Narayanaswamy; Parmar, Priya; Maujean, Annick; Ranta, Annemarei; Cadilhac, Dominique; Sanya, Emmanuel O; MacKay-Lyons, Marilyn; Pandian, Jeyaraj D; Arora, Deepti; Obiako, Reginald O; Saposnik, Gustavo; Balalla, Shivanthi; Bornstein, Natan M; Langhorne, Peter; Norrving, Bo; Brown, Nita; Brainin, Michael; Taylor, Denise; Feigin, Valery L

2018-05-01

To assess the feasibility of conducting a randomized controlled trial of an instructional and educational stroke DVD and determine the feasibility and preliminary efficacy of this intervention in a multinational context. Non-funded, pilot randomized controlled trial of intervention versus usual care. International, multicentre, community-based. Community-living adults up to three years post stroke with moderate to severe disability and their nominated informal caregivers. Intervention patients viewed and practised rehabilitation techniques demonstrated in the DVD over six weeks. Trial feasibility by number of active recruitment sites, recruitment efficiency, randomization and follow-up. Intervention feasibility by patient and caregiver impressions. Preliminary efficacy by the quality of life - 5-level EuroQol-5D (EQ-5D) health status measure, General Health Questionnaire and Centre for Epidemiological Studies-Depression at two months. In total, 14 recruitment sites were established across eight countries. Recruitment was achieved at nine (64%) sites. Over 16 months, 66 participants were recruited (mean (SD) age = 63.5 (12.47) years) and randomized to intervention ( n = 34) and control ( n = 32) groups. In total, 54 (82%) completed a follow-up assessment. Patient and/or caregiver comments about the benefits and barriers to accessing the intervention were mixed. There were no significant between-group differences in outcomes at two months ( P > 0.05). Conducting a multinational trial of a stroke DVD requires full funding. The intervention was acceptable to some patients and their caregivers, yet a generalized education approach did not fully meet their needs and/or expectations. A more individualized method may be required to meet peoples' changing needs during stroke recovery.

Feasibility, safety, acceptability, and preliminary efficacy of measurement-based care depression treatment for HIV patients in Bamenda, Cameroon.

PubMed

Pence, Brian W; Gaynes, Bradley N; Atashili, Julius; O'Donnell, Julie K; Kats, Dmitry; Whetten, Kathryn; Njamnshi, Alfred K; Mbu, Tabenyang; Kefie, Charles; Asanji, Shantal; Ndumbe, Peter

2014-06-01

Depression affects 18-30 % of HIV-infected patients in Africa and is associated with greater stigma, lower antiretroviral adherence, and faster disease progression. However, the region's health system capacity to effectively identify and treat depression is limited. Task-shifting models may help address this large mental health treatment gap. Measurement-Based Care (MBC) is a task-shifting model in which a Depression Care Manager guides a non-psychiatric (e.g., HIV) provider in prescribing and managing antidepressant treatment. We adapted MBC for depressed HIV-infected patients in Cameroon and completed a pilot study to assess feasibility, safety, acceptability, and preliminary efficacy. We enrolled 55 participants; all started amitriptyline 25-50 mg daily at baseline. By 12 weeks, most remained at 50 mg daily (range 25-125 mg). Median (interquartile range) PHQ-9 depressive severity scores declined from 13 (12-16) (baseline) to 2 (0-3) (week 12); 87 % achieved depression remission (PHQ-9 <5) by 12 weeks. Intervention fidelity was high: HIV providers followed MBC recommendations at 96 % of encounters. Most divergences reflected a failure to increase dose when indicated. No serious and few bothersome side effects were reported. Most suicidality (prevalence 62 % at baseline; 8 % at 12 weeks) was either passive or low-risk. Participant satisfaction was high (100 %), and most participants (89 %) indicated willingness to pay for medications if MBC were implemented in routine care. The adapted MBC intervention demonstrated high feasibility, safety, acceptability, and preliminary efficacy in this uncontrolled pilot study. Further research should assess whether MBC could improve adherence and HIV outcomes in this setting.

The Cambridge Otology Quality of Life Questionnaire: an otology-specific patient-recorded outcome measure. A paper describing the instrument design and a report of preliminary reliability and validity.

PubMed

Martin, T P C; Moualed, D; Paul, A; Ronan, N; Tysome, J R; Donnelly, N P; Cook, R; Axon, P R

2015-04-01

The Cambridge Otology Quality of Life Questionnaire (COQOL) is a patient-recorded outcome measurement (PROM) designed to quantify the quality of life of patients attending otology clinics. Item-reduction model. A systematically designed long-form version (74 items) was tested with patient focus groups before being presented to adult otology patients (n. 137). Preliminary item analysis tested reliability, reducing the COQOL to 24 questions. This was then presented in conjunction with the SF-36 (V1) questionnaire to a total of 203 patients. Subsequently, these were re-presented at T + 3 months, and patients recorded whether they felt their condition had improved, deteriorated or remained the same. Non-responders were contacted by post. A correlation between COQOL scores and patient perception of change was examined to analyse content validity. Teaching hospital and university psychology department. Adult patients attending otology clinics with a wide range of otological conditions. Item reliability measured by item–total correlation, internal consistency and test– retest reliability. Validity measured by correlation between COQOL scores and patient-reported symptom change. Reliability: the COQOL showed excellent internal consistency at both initial presentation (a = 0.90) and 3 months later (a = 0.93). Validity: One-way analysis of variance showed a significant difference between groups reporting change and those reporting no change in quality of life (F(2, 80) = 5.866, P < 0.01). The COQOL is the first otology-specific PROM. Initial studies demonstrate excellent reliability and encouraging preliminary criterion validity: further studies will allow a deeper validation of the instrument.

[Comorbid psychiatric symptoms in pathological gamblers: anxiety, depression and substance abuse].

PubMed

Dannon, Pinhas; Sason, Marina; Shalgi, Bosmat; Tusan, Lali; Sapir, Yafa; Kotler, Moshe

2004-09-01

Over the centuries, gambling behaviour has been well known and characterized by the combination of pleasure, luck and competition. Our study explored the relationship between pathological gambling, depression and anxiety. We also explored demographic findings and behavioural patterns of the pathological gamblers. Fourty-seven patients were included in this study and they anonymously completed questionnaires which included demographic findings, the Hamilton depression rating scale and the Hamilton anxiety rating scale. The study results demonstrated a strong correlation between depression, anxiety, substance abuse, and pathological gambling. It also presented lower income and higher anxiety levels associated with a higher tendency for gambling. The subjects suffering from depression and anxiety also showed higher levels of suicidality and other abuse dependencies. In order to confirm these preliminary results larger studies are needed in this field.

Feasibility, acceptability, and preliminary effectiveness of patient advocates for improving adult asthma outcomes

PubMed Central

Apter, Andrea J.; Wan, Fei; Reisine, Susan; Bogen, Daniel K.; Rand, Cynthia; Bender, Bruce; Bennett, Ian M.; Gonzalez, Rodalyn; Priolo, Chantel; Sonnad, Seema S.; Bryant-Stephens, Tyra; Ferguson, Monica; Boyd, Rhonda C.; Have, Thomas Ten; Roy, Jason

2014-01-01

Background Asthmatic adults from low-income urban neighborhoods have inferior health outcomes which in part may be due to barriers accessing care and with patient-provider communication. We adapted a patient advocate (PA) intervention to overcome these barriers. Objective To conduct a pilot study to assess feasibility, acceptability, and preliminary evidence of effectiveness. Methods A prospective randomized design was employed with mixed methods evaluation. Adults with moderate or severe asthma were randomized to 16 weeks of PA or a minimal intervention (MI) comparison condition. The PA, a nonprofessional, modeled preparations for a medical visit, attended the visit, and confirmed understanding. The PA facilitated scheduling, obtaining insurance coverage, and overcoming barriers to implementing medical advice. Outcomes included electronically-monitored inhaled corticosteroid adherence, asthma control, quality of life, FEV1, ED visits, and hospitalizations. Mixed-effects models guided an intention-to-treat analysis. Results 100 adults participated: age 47±14 years, 75% female, 71% African American, 16% white, baseline FEV1 69% ± 18%, 36% experiencing hospitalizations and 56% ED visits for asthma in the prior year. Ninety-three subjects completed all visits; 36 of 53 PA-assigned had a PA visit. Adherence declined significantly in the control (p= 0.001) but not significantly in the PA group (p=.30). Both PA and MI groups demonstrated improved asthma control (p=0.01 in both) and quality of life (p=0.001, p=0.004). Hospitalizations and ED visits for asthma did not differ between groups. The observed changes over time tended to favor the PA group, but this study was underpowered to detect differences between groups. Conclusion The PA intervention was feasible and acceptable and demonstrated potential for improving asthma control and quality of life. PMID:23800333

Development and full validation of an UPLC-MS/MS method for the determination of an anti-allergic indolinone derivative in rat plasma, and application to a preliminary pharmacokinetic study.

PubMed

Oufir, Mouhssin; Sampath, Chethan; Butterweck, Veronika; Hamburger, Matthias

2012-08-01

The natural product (E,Z)-3-(4-hydroxy-3,5-dimethoxybenzylidene)indolin-2-one (indolinone) was identified some years ago as a nanomolar inhibitor of FcɛRI-receptor dependent mast cell degranulation. To further explore the potential of the compound, we established an UPLC-MS/MS assay for dosage in rat plasma. The method was fully validated according to FDA Guidance for industry. Results of this validation and long term stability study demonstrate that the method in lithium heparinized rat plasma is specific, accurate, precise and capable of producing reliable results according to recommendations of international guidelines. The method was validated with a LLOQ of 30.0 ng/mL and an ULOQ of 3000 ng/mL. The response versus concentration data were fitted with a first order polynomial with 1/X(2) weighting. No matrix effect was observed when using three independent sources of rat plasma. The average extraction recovery was consistent over the investigated range. This validation in rat plasma demonstrated that indolinone was stable for 190 days when stored below -65 °C; for 4 days at 10 °C in the autosampler; for 4h at RT, and during three successive freeze/thaw cycles at -65 °C. Preliminary pharmacokinetic data were obtained in male Sprague-Dawley rats (2 mg/kg BW i.v.). Blood samples taken from 0 to 12 h after injection were collected, and data analyzed with WinNonlin. A short half-life (4.30±0.14 min) and a relatively high clearance (3.83±1.46 L/h/kg) were found. Copyright © 2012 Elsevier B.V. All rights reserved.

Health-related quality of life questionnaire for polycystic ovary syndrome (PCOSQ-50): development and psychometric properties.

PubMed

Nasiri-Amiri, Fatemeh; Ramezani Tehrani, Fahimeh; Simbar, Masoumeh; Montazeri, Ali; Mohammadpour, Reza Ali

2016-07-01

The determinants of the health-related quality of life of women with polycystic ovary syndrome are not fully understood. The aim of this study was to develop a comprehensive instrument to assess the health-related quality of life of Iranian women with PCOS and to assess its psychometric properties. We used a mixed-method, sequential, exploratory design including both qualitative [in-depth interview to define the components of health-related quality of life questionnaire (PCOSQ)] and quantitative approaches (to assess the psychometric properties of PCOSQ). A preliminary questionnaire was developed including 147 items which emerged from the qualitative phase of the study. Considering the optimum cutoff points for content validity ratio (CVR), content validity index (CVI), and impact score, items of the preliminary questionnaire were reduced from 147 to 88 items. Finally, by excluding highly correlated items using the exploratory factor analysis, a 50-item questionnaire was obtained. The Kaiser criteria (eigenvalues >1) and Scree plot tests demonstrated that six factors were optimum with an estimated 47.3 % of variance. Assessment of the psychometric properties of the questionnaire demonstrated a mean CVI = 0.92, CVR = 0.91, Cronbach's alpha for whole questionnaire = 0.88 (0.61-0.88 for subscales), Spearman's correlation coefficients of test-retest = 0.75, and the intra-class correlation coefficient for the PCOS questionnaire subscales ranging from 0.57 to 0.88. Eventually the final questionnaire included 50 items in six domains, 'psychosocial and emotional,' 'fertility,' 'sexual function,' 'obesity and menstrual disorders,' 'hirsutism,' and 'coping' and rated on a 5-point Likert scale. The PCOSQ-50 is a valid and reliable instrument for the assessment of quality of life of women with PCOS, capable of assessing some obscure aspects overlooked by previous HRQL questionnaires.

Off-target model based OPC

NASA Astrophysics Data System (ADS)

Lu, Mark; Liang, Curtis; King, Dion; Melvin, Lawrence S., III

2005-11-01

Model-based Optical Proximity correction has become an indispensable tool for achieving wafer pattern to design fidelity at current manufacturing process nodes. Most model-based OPC is performed considering the nominal process condition, with limited consideration of through process manufacturing robustness. This study examines the use of off-target process models - models that represent non-nominal process states such as would occur with a dose or focus variation - to understands and manipulate the final pattern correction to a more process robust configuration. The study will first examine and validate the process of generating an off-target model, then examine the quality of the off-target model. Once the off-target model is proven, it will be used to demonstrate methods of generating process robust corrections. The concepts are demonstrated using a 0.13 μm logic gate process. Preliminary indications show success in both off-target model production and process robust corrections. With these off-target models as tools, mask production cycle times can be reduced.

Neuroprotective antioxidants from marijuana.

PubMed

Hampson, A J; Grimaldi, M; Lolic, M; Wink, D; Rosenthal, R; Axelrod, J

2000-01-01

Cannabidiol and other cannabinoids were examined as neuroprotectants in rat cortical neuron cultures exposed to toxic levels of the neurotransmitter, glutamate. The psychotropic cannabinoid receptor agonist delta 9-tetrahydrocannabinol (THC) and cannabidiol, (a non-psychoactive constituent of marijuana), both reduced NMDA, AMPA and kainate receptor mediated neurotoxicities. Neuroprotection was not affected by cannabinoid receptor antagonist, indicating a (cannabinoid) receptor-independent mechanism of action. Glutamate toxicity can be reduced by antioxidants. Using cyclic voltametry and a fenton reaction based system, it was demonstrated that Cannabidiol, THC and other cannabinoids are potent antioxidants. As evidence that cannabinoids can act as an antioxidants in neuronal cultures, cannabidiol was demonstrated to reduce hydroperoxide toxicity in neurons. In a head to head trial of the abilities of various antioxidants to prevent glutamate toxicity, cannabidiol was superior to both alpha-tocopherol and ascorbate in protective capacity. Recent preliminary studies in a rat model of focal cerebral ischemia suggest that cannabidiol may be at least as effective in vivo as seen in these in vitro studies.

Flight Dynamics Modeling and Simulation of a Damaged Transport Aircraft

NASA Technical Reports Server (NTRS)

Shah, Gautam H.; Hill, Melissa A.

2012-01-01

A study was undertaken at NASA Langley Research Center to establish, demonstrate, and apply methodology for modeling and implementing the aerodynamic effects of MANPADS damage to a transport aircraft into real-time flight simulation, and to demonstrate a preliminary capability of using such a simulation to conduct an assessment of aircraft survivability. Key findings from this study include: superpositioning of incremental aerodynamic characteristics to the baseline simulation aerodynamic model proved to be a simple and effective way of modeling damage effects; the primary effect of wing damage rolling moment asymmetry may limit minimum airspeed for adequate controllability, but this can be mitigated by the use of sideslip; combined effects of aerodynamics, control degradation, and thrust loss can result in significantly degraded controllability for a safe landing; and high landing speeds may be required to maintain adequate control if large excursions from the nominal approach path are allowed, but high-gain pilot control during landing can mitigate this risk.

Composition and potential origin of marine debris stranded in the Western Indian Ocean on remote Alphonse Island, Seychelles.

PubMed

Duhec, Aurélie V; Jeanne, Richard F; Maximenko, Nikolai; Hafner, Jan

2015-07-15

The abundance, composition, and potential sources of marine debris were investigated on remote Alphonse Island, during the austral winter 2013. A total of 4743 items, weighing 142 kg, were removed from 1 km of windward beach, facing the prevailing southeasterly trade winds. Our study demonstrates the prevalence of plastic debris as a world-wide marine contaminant. Characteristics of the debris suggest it originated primarily from land-based sources. To determine their potential geographic sources we used the Surface Current from Diagnostic model of near-surface ocean currents, forced by satellite sea level and wind data. While preliminary evidence indicated the Southeast Asia to be the main source of the flotsam, the model highlighted Somalia as another potential primary source. Our study concludes that most of the collected debris entered the sea as a result of inadequate waste management and demonstrates how anthropogenic waste can negatively impact even the most remote environments. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

The effect of conformation on orthopaedic health and performance in a cohort of National Hunt racehorses: preliminary results.

PubMed

Weller, R; Pfau, T; Verheyen, K; May, S A; Wilson, A M

2006-11-01

There is a lack of scientific data and studies on the effect of conformation on performance or on orthopaedic health. To investigate the relationship between conformation, injury and performance in racehorses used for racing over fences. Over 2 years, 108 National Hunt racehorses were followed and their medical and performance data recorded. Conformation was measured in 3D with a computerised motion analysis system. Linear multiple regression models were used to evaluate the effect of conformation on measures of race performance and stepwise forward logistic regression models to assess the effect on risk of injury. An increase in intermandibular width, flexor angle of the shoulder joint and coxal angle (the angle between the ilium and ischium) was demonstrated to have a positive effect on performance. Performance decreased with increasing girth, length of the hind digit and valgus conformation of the metacarpophalangeal joint. The risk of suffering from superficial digital flexor tendon injury increased with increasing metacarpophalangeal joint angle and with carpus valgus conformation. The risk of pelvic fracture increased with valgus conformation of the tarsus and decreased with an increasing coxal angle. Valgus deformation was demonstrated to be detrimental to performance or increased risk of injury, perhaps resulting in higher loads on musculoskeletal structures. The coxal angle was the only parameter to have an effect on both risk of injury and performance. An alignment of the muscles with the axis of the pelvis may be beneficial for force transmission and decrease the bending moment of the muscles on the bones. The statistical power of this study is limited, however it provides preliminary data necessary for the planning of a larger scale study on the effect of conformation on performance and risk of injury. Studies of the effects of conformation on performance and risk of injury may aid in identifying individuals likely to perform well on the racecourse and avoid risks of injury.

ASTP fluid transfer measurement experiment. [using breadboard model

NASA Technical Reports Server (NTRS)

Fogal, G. L.

1974-01-01

The ASTP fluid transfer measurement experiment flight system design concept was verified by the demonstration and test of a breadboard model. In addition to the breadboard effort, a conceptual design of the corresponding flight system was generated and a full scale mockup fabricated. A preliminary CEI specification for the flight system was also prepared.

43 CFR 4.1353 - Contents of request.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Contents of request. 4.1353 Section 4.1353 Public Lands: Interior Office of the Secretary of the Interior DEPARTMENT HEARINGS AND APPEALS PROCEDURES Special Rules Applicable to Surface Coal Mining Hearings and Appeals Request for Hearing on A Preliminary Finding Concerning A Demonstrated...

The Use of Video Self-Modeling with English Language Learners: Implications for Success

ERIC Educational Resources Information Center

Ortiz, Jennifer; Burlingame, Cheryl; Onuegbulem, Cybeles; Yoshikawa, Koichi; Rojas, Eliana D.

2012-01-01

The efficacy of video self-modeling (VSM) to improve reading fluency for English language learners (ELLs) is explored. A review of the literature demonstrates the success of VSM in improving non-ELL students' fluency. Preliminary research with culturally and linguistically diverse students implies that the intervention can be equally effective…

Feasibility of Group Voice Therapy for Individuals with Parkinson's Disease

ERIC Educational Resources Information Center

Searl, Jeff; Wilson, Kristel; Haring, Karen; Dietsch, Angela; Lyons, Kelly; Pahwa, Rajesh

2011-01-01

Purpose: The primary purpose was to demonstrate the feasibility of executing treatment tasks focused on increasing loudness in a group format for individuals with Parkinson's disease (PD). A second purpose was to report preliminary pre-to-post treatment outcomes for individuals with PD immediately after they complete the group program. Methods:…

Improving the Language Skills of Pre-Kindergarten Students: Preliminary Impacts of the "Let's Know!" Experimental Curriculum

ERIC Educational Resources Information Center

Johanson, Megan; Arthur, Ann M.

2016-01-01

Background: Improving children's oral language skills is an important focus of educational research and practice; however, relatively few interventions have demonstrated impacts on these skills. This work makes a unique contribution to our understanding of the effects of language-focused interventions in pre-kindergarten settings by examining…

GABA[subscript A] Receptor Downregulation in Brains of Subjects with Autism

ERIC Educational Resources Information Center

Fatemi, S. Hossein; Reutiman, Teri J.; Folsom, Timothy D.; Thuras, Paul D.

2009-01-01

Gamma-aminobutyric acid A (GABA[subscript A]) receptors are ligand-gated ion channels responsible for mediation of fast inhibitory action of GABA in the brain. Preliminary reports have demonstrated altered expression of GABA receptors in the brains of subjects with autism suggesting GABA/glutamate system dysregulation. We investigated the…

An Analysis of School Wide Supports and Barriers to Collaborative Problem Solving Teams

ERIC Educational Resources Information Center

Ciampaglia, Brie I.

2010-01-01

While there is preliminary evidence supporting the use of collaborative problem solving teams in schools (e.g., Telzrow, McNamara, & Hollinger, 2000) only a few outcome measures have been explored in relation to these procedures, and the results have been inconsistently demonstrated across projects (Burns & Symington, 2002). Additionally, it has…

Spanish Translation and Validation of the Bracken Basic Concept Scale.

ERIC Educational Resources Information Center

Bracken, Bruce A; Fouad, Nadya

1987-01-01

The Bracken Basic Concept Scale (BBCS) was translated into Spanish, and 32 preschool and primary age bilingual children were assessed in a counter-balanced format with the English and newly translated Spanish forms to assess the adequacy of the translation. Preliminary content validity of the Spanish BBCS was demonstrated. (Author/JAZ)

Demonstration Report for Visual Sample Plan (VSP) Verification Sampling Methods at the Navy/DRI Site

DTIC Science & Technology

2011-08-01

population of 537,197 with an overall population density of 608 people per square mile (people/ mi2 ). However, the population density in the vicinity...Preliminary Assessment Findings  approximately 12 people/ mi2 . Population density is expected to greatly increase following development of the site

Internet-Based Training to Improve Preschool Playground Safety: Evaluation of the Stamp-in-Safety Programme

ERIC Educational Resources Information Center

Schwebel, David C.; Pennefather, Jordan; Marquez, Brion; Marquez, Jessie

2015-01-01

Objective: Playground injuries result in over 200,000 US pediatric emergency department visits annually. One strategy to reduce injuries is improved adult supervision. The Stamp-in-Safety programme, which involves supervisors stamping rewards for children playing safely, has been demonstrated in preliminary classroom-based work to reduce child…

Child Abuse and Neglect: A Report on the Status of the Research.

ERIC Educational Resources Information Center

Hurt, Maure, Jr.

This state-of-the-art report provides preliminary information on the status of child abuse and neglect research projects currently in progress or recently completed. Each chapter discusses a particular research problem area and outlines the relevant demonstration projects. Chapter I describes the background of our present perception of child abuse…

LINKING AIR TOXIC CONCENTRATIONS FROM CMAQ TO THE HAPEM5 EXPOSURE MODEL AT NEIGHORHOOD SCALES FOR THE PHILADELPHIA AREA

EPA Science Inventory

This paper provides a preliminary demonstration of the EPA neighborhood scale modeling paradigm for air toxics by linking concentration from the Community Multi-scale Air Quality (CMAQ) modeling system to the fifth version of the Hazardous Pollutant Exposure Model (HAPEM5). For ...

Training Directors' Conceptualizations of the Intersections of Diversity and Trainee Competence Problems: A Preliminary Analysis

ERIC Educational Resources Information Center

Miller, David S. Shen; Forrest, Linda; Elman, Nancy S.

2009-01-01

Counseling psychology has demonstrated leadership on multicultural issues through serious and committed attention to diversity in scholarship, conferences, and training and recruitment. Yet a survey of the literature on trainees with competence problems resulted in limited references to race/ethnicity and/or gender (REG). Using transcripts of…

Affordable Development and Demonstrationof a Small NTR Engine and Stage: A Preliminary NASA, DOE and Industry Assessment

NASA Technical Reports Server (NTRS)

Borowski, Stanley K.; Sefcik, Robert J.; Qualls, A. L.; Schnitzler, B.G.; Joyner, C. R.

2014-01-01

Formulation of Affordable and Sustainable NTP Development Strategy is Underway Involving NASA, DOE and Industry. In FY11, Nuclear Thermal Propulsion (NTP) was identified as a key propulsion option under the Advanced In-Space Propulsion (AISP) component of NASA's Exploration Technology Development and Demonstration (ETDD) program.

Green's function solution to radiative heat transfer between longitudinal gray fins

NASA Technical Reports Server (NTRS)

Frankel, J. I.; Silvestri, J. J.

1991-01-01

A demonstration is presented of the applicability and versatility of a pure integral formulation for radiative-conductive heat-transfer problems. Preliminary results have been obtained which indicate that this formulation allows an accurate, fast, and stable computation procedure to be implemented. Attention is given to the accessory problem defining Green's function.

Progress Towards a Cartesian Cut-Cell Method for Viscous Compressible Flow

NASA Technical Reports Server (NTRS)

Berger, Marsha; Aftosmis, Michael J.

2011-01-01

The proposed paper reports advances in developing a method for high Reynolds number compressible viscous flow simulations using a Cartesian cut-cell method with embedded boundaries. This preliminary work focuses on accuracy of the discretization near solid wall boundaries. A model problem is used to investigate the accuracy of various difference stencils for second derivatives and to guide development of the discretization of the viscous terms in the Navier-Stokes equations. Near walls, quadratic reconstruction in the wall-normal direction is used to mitigate mesh irregularity and yields smooth skin friction distributions along the body. Multigrid performance is demonstrated using second-order coarse grid operators combined with second-order restriction and prolongation operators. Preliminary verification and validation for the method is demonstrated using flat-plate and airfoil examples at compressible Mach numbers. Simulations of flow on laminar and turbulent flat plates show skin friction and velocity profiles compared with those from boundary-layer theory. Airfoil simulations are performed at laminar and turbulent Reynolds numbers with results compared to both other simulations and experimental data

Wayside energy storage study. Volume 4 : dual-mode locomotive : preliminary design study

DOT National Transportation Integrated Search

1979-02-01

A preliminary design study was conducted to confirm the technical viability and economic attractiveness of the dual-mode locomotive concept based on the most common U.S. road locomotive, the SD40-2. The study examined the existing characteristics of ...

Transforming youth mental health services and supports in Ireland.

PubMed

Illback, Robert J; Bates, Tony

2011-02-01

Young people in the Republic of Ireland do not have access to appropriate mental health services and supports, necessitating transformational change in delivery systems. Describe ongoing development and change efforts facilitated by Headstrong--The National Centre for Youth Mental Health. Discusses findings from a national needs assessment, core strategies within the change initiative, progress in system-building, and preliminary descriptive and outcome data. Five demonstration sites comprised of four counties and a city neighbourhood are operational and preliminary data are promising with respect to implementation and outcomes. Effective change initiatives require vision and leadership, competence- and capacity-building, participative planning and engagement, adequate and thoughtfully deployed resources, and a comprehensive change management approach. © 2011 Blackwell Publishing Asia Pty Ltd.

The preliminary checkout, evaluation and calibration of a 3-component force measurement system for calibrating propulsion simulators for wind tunnel models

NASA Technical Reports Server (NTRS)

Scott, W. A.

1984-01-01

The propulsion simulator calibration laboratory (PSCL) in which calibrations can be performed to determine the gross thrust and airflow of propulsion simulators installed in wind tunnel models is described. The preliminary checkout, evaluation and calibration of the PSCL's 3 component force measurement system is reported. Methods and equipment were developed for the alignment and calibration of the force measurement system. The initial alignment of the system demonstrated the need for more efficient means of aligning system's components. The use of precision alignment jigs increases both the speed and accuracy with which the system is aligned. The calibration of the force measurement system shows that the methods and equipment for this procedure can be successful.

Bistatic radar sea state monitoring

NASA Technical Reports Server (NTRS)

Ruck, G. T.; Barrick, D. E.; Kaliszewski, T.

1972-01-01

Bistatic radar techniques were examined for remote measurement of the two-dimensional surface wave height spectrum of the ocean. One technique operates at high frequencies (HF), 3-30 MHz, and the other at ultrahigh frequencies (UHF), approximately 1 GHz. Only a preliminary theoretical examination of the UHF technique was performed; however the principle underlying the HF technique was demonstrated experimentally with results indicating that an HF bistatic system using a surface transmitter and an orbital receiver would be capable of measuring the two-dimensional wave height spectrum in the vicinity of the transmitter. An HF bistatic system could also be used with an airborne receiver for ground truth ocean wave spectrum measurements. Preliminary system requirements and hardware configurations are discussed for both an orbital system and an aircraft verification experiment.

Preliminary design of Viking Armored Gun System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gogolewski, R.P.; Cunningham, B.J.

We have completed the preliminary design of our third lightweight armored fighting vehicle -- the Viking Armored Gun System (AGS). The AGS vehicle features a two-man crew, the Ares 75mm Universal Turret System, and the John Deere 4026R Rotary Engine. In the spirit of our earlier AFV designs, our primary concern is to provide the AGS with sufficient firepower and survivability while utilizing off-the-shelf'' sub-systems and components in order to reduce developmental time and acquisition cost. We still envision that prototypic vehicles could be built within a thirty (30) month developmental/demonstration program. We still believe that vehicles of this classmore » should be built and tested soon to assess their full tactical, operational, and strategic utilities.« less

Validity and reliability of the NAB Naming Test.

PubMed

Sachs, Bonnie C; Rush, Beth K; Pedraza, Otto

2016-05-01

Confrontation naming is commonly assessed in neuropsychological practice, but few standardized measures of naming exist and those that do are susceptible to the effects of education and culture. The Neuropsychological Assessment Battery (NAB) Naming Test is a 31-item measure used to assess confrontation naming. Despite adequate psychometric information provided by the test publisher, there has been limited independent validation of the test. In this study, we investigated the convergent and discriminant validity, internal consistency, and alternate forms reliability of the NAB Naming Test in a sample of adults (Form 1: n = 247, Form 2: n = 151) clinically referred for neuropsychological evaluation. Results indicate adequate-to-good internal consistency and alternate forms reliability. We also found strong convergent validity as demonstrated by relationships with other neurocognitive measures. We found preliminary evidence that the NAB Naming Test demonstrates a more pronounced ceiling effect than other commonly used measures of naming. To our knowledge, this represents the largest published independent validation study of the NAB Naming Test in a clinical sample. Our findings suggest that the NAB Naming Test demonstrates adequate validity and reliability and merits consideration in the test arsenal of clinical neuropsychologists.

A Clinical Feasibility Study of Atrial and Ventricular Electromechanical Wave Imaging

PubMed Central

Provost, Jean; Gambhir, Alok; Vest, John; Garan, Hasan; Konofagou, Elisa E.

2014-01-01

Background Cardiac Resynchronization Therapy (CRT) and atrial ablation currently lack a noninvasive imaging modality for reliable treatment planning and monitoring. Electromechanical Wave Imaging (EWI) is an ultrasound-based method that has previously been shown to be capable of noninvasively and transmurally mapping the activation sequence of the heart in animal studies by estimating and imaging the electromechanical wave, i.e., the transient strains occurring in response to the electrical activation, at both very high temporal and spatial resolution. Objective Demonstrate the feasibility of noninvasive transthoracic EWI for mapping the activation sequence during different cardiac rhythms in humans. Methods EWI was performed in CRT patients with a left bundle-branch block (LBBB), during sinus rhythm, left-ventricular pacing, and right-ventricular pacing and in atrial flutter (AFL) patients before intervention and correlated with results from invasive intracardiac electrical mapping studies during intervention. Additionally, the feasibility of single-heartbeat EWI at 2000 frames/s, is demonstrated in humans for the first time in a subject with both AFL and right bundle-branch-block. Results The electromechanical activation maps demonstrated the capability of EWI to localize the pacing sites and characterize the LBBB activation sequence transmurally in CRT patients. In AFL patients, the propagation patterns obtained with EWI were in agreement with results obtained from invasive intracardiac mapping studies. Conclusion Our findings demonstrate the potential capability of EWI to aid in monitoring and follow-up of patients undergoing CRT pacing therapy and atrial ablation with preliminary validation in vivo. PMID:23454060

Fabrication and characterization of graphene hydrogel via hydrothermal approach as a scaffold for preliminary study of cell growth

PubMed Central

Lim, HN; Huang, NM; Lim, SS; Harrison, I; Chia, CH

2011-01-01

Background Three-dimensional assembly of graphene hydrogel is rapidly attracting the interest of researchers because of its wide range of applications in energy storage, electronics, electrochemistry, and waste water treatment. Information on the use of graphene hydrogel for biological purposes is lacking, so we conducted a preliminary study to determine the suitability of graphene hydrogel as a substrate for cell growth, which could potentially be used as building blocks for biomolecules and tissue engineering applications. Methods A three-dimensional structure of graphene hydrogel was prepared via a simple hydrothermal method using two-dimensional large-area graphene oxide nanosheets as a precursor. Results The concentration and lateral size of the graphene oxide nanosheets influenced the structure of the hydrogel. With larger-area graphene oxide nanosheets, the graphene hydrogel could be formed at a lower concentration. X-ray diffraction patterns revealed that the oxide functional groups on the graphene oxide nanosheets were reduced after hydrothermal treatment. The three-dimensional graphene hydrogel matrix was used as a scaffold for proliferation of a MG63 cell line. Conclusion Guided filopodia protrusions of MG63 on the hydrogel were observed on the third day of cell culture, demonstrating compatibility of the graphene hydrogel structure for bioapplications. PMID:21931479

The development of intonation in young children with cochlear implants: A preliminary study of the influence of age at implantation and length of implant experience

PubMed Central

Snow, David; Ertmer, David

2010-01-01

This study describes the development of emerging intonation in six children who had received a cochlear implant (CI) before the age of three years. At the time their implant was activated, the children ranged in age from 11 to 37 months. Spontaneous longitudinal speech samples were recorded from 30-minute sessions in which the child interacted with his or her mother. Data were collected 2 months before activation of each child's CI and at monthly intervals after activation for 6 months. The findings were compared to the typical pattern of early intonation development in children with normal hearing (NH). The results suggested that young CI recipients progress through stages similar to those observed in children with NH. However, the intonation development of children with a CI reflects a marked interaction between chronological age at implantation and amount of CI experience. That is, after 2 months of CI-assisted hearing experience, the older children demonstrated a later stage of intonation development than younger children. These preliminary results support the idea that children acquire some foundations or prerequisites of intonation production through maturation, as measured by chronological age, even without robust auditory experience. PMID:20882119

Preliminary evidence that different mechanisms underlie the anger superiority effect in children with and without Autism Spectrum Disorders

PubMed Central

Isomura, Tomoko; Ogawa, Shino; Yamada, Satoko; Shibasaki, Masahiro; Masataka, Nobuo

2014-01-01

Previous studies have demonstrated that angry faces capture humans' attention more rapidly than emotionally positive faces. This phenomenon is referred to as the anger superiority effect (ASE). Despite atypical emotional processing, adults and children with Autism Spectrum Disorders (ASD) have been reported to show ASE as well as typically developed (TD) individuals. So far, however, few studies have clarified whether or not the mechanisms underlying ASE are the same for both TD and ASD individuals. Here, we tested how TD and ASD children process schematic emotional faces during detection by employing a recognition task in combination with a face-in-the-crowd task. Results of the face-in-the-crowd task revealed the prevalence of ASE both in TD and ASD children. However, the results of the recognition task revealed group differences: In TD children, detection of angry faces required more configural face processing and disrupted the processing of local features. In ASD children, on the other hand, it required more feature-based processing rather than configural processing. Despite the small sample sizes, these findings provide preliminary evidence that children with ASD, in contrast to TD children, show quick detection of angry faces by extracting local features in faces. PMID:24904477

Indirect zirconia-reinforced lithium silicate ceramic CAD/CAM restorations: Preliminary clinical results after 12 months.

PubMed

Zimmermann, Moritz; Koller, Christina; Mehl, Albert; Hickel, Reinhard

2017-01-01

No clinical data are available for the new computer-aided design/computer-assisted manufacture (CAD/CAM) material zirconia-reinforced lithium silicate (ZLS) ceramic. This study describes preliminary clinical results for indirect ZLS CAD/CAM restorations after 12 months. Indirect restorations were fabricated, using the CEREC method and intraoral scanning (CEREC Omnicam, CEREC MCXL). Sixty-seven restorations were seated adhesively (baseline). Sixty restorations were evaluated after 12 months (follow-up), using modified FDI criteria. Two groups were established, according to ZLS restorations' post-processing procedure prior to adhesive seating: group I (three-step polishing, n = 32) and group II (fire glazing, n = 28). Statistical analysis was performed with Mann-Whitney U test and Wilcoxon test (P < .05). The success rate of indirect ZLS CAD/CAM restorations after 12 months was 96.7%. Two restorations clinically failed as a result of bulk fracture (failure rate 3.3%). No statistically significant differences were found for baseline and follow-up criteria (Wilcoxon test, P > .05). Statistically significant differences were found for criteria surface gloss for group I and group II (Mann-Whitney U test, P < .05). This study demonstrates ZLS CAD/CAM restorations have a high clinical success rate after 12 months. A longer clinical evaluation period is necessary to draw further conclusions.

Sewage sludge drying by energy recovery from OFMSW composting: preliminary feasibility evaluation.

PubMed

Rada, Elena Cristina; Ragazzi, Marco; Villotti, Stefano; Torretta, Vincenzo

2014-05-01

In this paper an original energy recovery method from composting is analyzed. The integrated system exploits the heat available from the aerobic biochemical process in order to support the drying of sewage sludge, using a specific solar greenhouse. The aim is to tackle the problem of organic waste treatment, with specific regard to food waste. This is done by optimizing the energy consumption of the aerobic process of composting, using the heat produced to solve a second important waste management problem such as the sewage waste treatment. Energy and mass balances are presented in a preliminary feasibility study. Referring to a composting plant with a capacity of 15,000 t/y of food waste, the estimation of the power from recovered heat for the entire plant resulted about 42 kW. The results demonstrated that the energy recoverable can cover part of the heat necessary for the treatment of sludge generated by the population served by the composting plant (in terms of food waste and green waste collection). The addition of a renewable source such as solar energy could cover the residual energy demand. The approach is presented in detail in order for it to be replicated in other case studies or at full scale applications. Copyright © 2014 Elsevier Ltd. All rights reserved.

[Mobbing, organizational dysfunction and bio-psycho-social effects: an integrated assessment. Preliminary data for the validation of the Questionnaire in the Neapoletan dialect on Distress at Work(Qn-DL)].

PubMed

Nolfe, Giovanni; Petrella, Claudio; Triassi, Maria; Zontini, Gemma; Uttieri, Simona; Pagliaro, Alessia; Blasi, Francesco; Cappuccio, Antonella; Nolfe, Giuseppe

2013-01-01

The aim of this study is to produce preliminary data about the validation of the "Naples-Questionnaire of Distress at Work" (nQ.DW). This inventory is a new assessment tool in order to evaluate the distress perceived in the working environment by means of the differentiation of the conditions linked to the mobbing from which related to organizational disfunction. The nQ-DW also measures the bio-psycho-social global effects of these two phenomena. The questionnaire has been administered to workers suffering of a psychopathological disturbance related to work distress and to a control group matched for the sociodemographic and working variables. The statistical analysis demonstrated a significant validity and reliability. The degree of internal coherence was satisfactory. The ROC curves allow the determination of a threshold value which allows to separate the workers subjected to mobbing and/or organizational stress from control-workers with an optimal reliability degree. The values of the area under the ROC curves show that the inventory has a high discriminating capacity. Future studies, based on a greater sample size, will be oriented to the analysis of the questionnaire by means of multivariate techniques like the factorial analysis.

Targeting premeal anxiety in eating disordered clients and normal controls: a preliminary investigation into the use of mindful eating vs. distraction during food exposure.

PubMed

Marek, Ryan J; Ben-Porath, Denise D; Federici, Anita; Wisniewski, Lucene; Warren, Mark

2013-09-01

Studies have demonstrated that negative affect increases prior to food intake in individuals diagnosed with an eating disorder. Mindfulness has been supported empirically to treat experiential avoidance stemming from anxiety. Thus, the current objective in this study is to empirically compare mindfulness vs. thought suppression invention during a food exposure in both clinical and nonclinical samples. In a 2 (Group: clinical vs. nonclinical) × 2 (INTERVENTION: mindfulness vs. distraction) counterbalanced within treatment design, the current investigation sought to determine the differential effectiveness of a brief mindfulness intervention vs. a brief distraction intervention in women diagnosed with AN and BN in a clinical and nonclinical sample during a food exposure. Results indicated that the eating disorder group reported a significant increase in negative affect after the mindfulness intervention as compared to the distraction intervention, whereas the nonclinical group reported a significant decrease in negative affect after the mindfulness intervention as compared to the distraction intervention. Preliminary findings suggest that clinicians may want to proceed cautiously when using mindful eating in those with severe eating disorders during the early stages of food exposure. Limitations and future directions are discussed. Copyright © 2013 Wiley Periodicals, Inc.

Correlation of ultrasound imaging of oral swallow with ventilatory alterations in cerebral palsied and normal children: preliminary observations.

PubMed

Kenny, D J; Casas, M J; McPherson, K A

1989-01-01

Preliminary results of an investigation that synchronizes the videotaped output of ultrasound camera and the analog data from physiological measurements of swallowing and ventilation in normal and cerebral palsied (CP) children are presented. Four cerebral palsied children and three control children undertook a single sip-swallow of 5 ml of liquid and a solid mastication-swallow sequence on three occasions according to a defined protocol. The CP children exhibited much more variability and less control of the liquid bolus than did the controls. The ultrasound image clearly demonstrates the lack of control of the posterior of the tongue in many CP children. Some parts of the sequence of oral swallow and the time to achieve maximum anterior displacement of the hyoid bone appear to be slowed. The sequential events of swallowing show less variability as the sip-swallow proceeds from the oral voluntary to pharyngeal and lower involuntary phases. This study also identified a short-latency apnea that appears to accompany a saliva (protective) swallow and a long-latency apnea that accompanies semi-solid or liquid bolus (alimentary) swallows. Further investigations of normal and CP children utilizing a combined diagnostic imaging-physiological measurement approach will follow this initial study.

Preliminary study on X-ray fluorescence computed tomography imaging of gold nanoparticles: Acceleration of data acquisition by multiple pinholes scheme

NASA Astrophysics Data System (ADS)

Sasaya, Tenta; Sunaguchi, Naoki; Seo, Seung-Jum; Hyodo, Kazuyuki; Zeniya, Tsutomu; Kim, Jong-Ki; Yuasa, Tetsuya

2018-04-01

Gold nanoparticles (GNPs) have recently attracted attention in nanomedicine as novel contrast agents for cancer imaging. A decisive tomographic imaging technique has not yet been established to depict the 3-D distribution of GNPs in an object. An imaging technique known as pinhole-based X-ray fluorescence computed tomography (XFCT) is a promising method that can be used to reconstruct the distribution of GNPs from the X-ray fluorescence emitted by GNPs. We address the acceleration of data acquisition in pinhole-based XFCT for preclinical use using a multiple pinhole scheme. In this scheme, multiple projections are simultaneously acquired through a multi-pinhole collimator with a 2-D detector and full-field volumetric beam to enhance the signal-to-noise ratio of the projections; this enables fast data acquisition. To demonstrate the efficacy of this method, we performed an imaging experiment using a physical phantom with an actual multi-pinhole XFCT system that was constructed using the beamline AR-NE7A at KEK. The preliminary study showed that the multi-pinhole XFCT achieved a data acquisition time of 20 min at a theoretical detection limit of approximately 0.1 Au mg/ml and at a spatial resolution of 0.4 mm.

Designing Effective EPO Products for Museums: Preliminary Evaluation Findings from the Interstellar Boundary Explorer (IBEX) EPO Program

NASA Astrophysics Data System (ADS)

Nichols, M.; Bartolone, L.; Baldassari, C.; Hoyer-Winfield, S.

2011-09-01

The Interstellar Boundary Explorer (IBEX) mission includes a comprehensive EPO program in astronomy and heliophysics that is overseen and implemented by the Adler Planetarium in Chicago, Illinois. Several EPO components were developed specifically for informal institutions, especially museums and planetaria. The program includes an internationally distributed planetarium show with accompanying informal educational materials. Our evaluator, the Program Evaluation and Research Group (PERG) at Lesley University, Cambridge, Massachusetts, assesses the effectiveness of the EPO program. In late 2009 through early 2010, more than 70 planetaria worldwide received the IBEX planetarium show. Of the many U.S. planetaria, the first 25 received the IBEX planetarium show and were offered the opportunity to receive, at no charge, accompanying informal education materials, including posters, lithographs, demonstration materials, lesson plans, and more. In Spring 2010, PERG staff conducted a study designed to gauge the effectiveness of the distribution process for the planetarium show, gather information on the professional development needs of the organizations, and document reactions of museum staff to the IBEX informal education materials and their usefulness as companion pieces to the planetarium show. In this paper, we will present preliminary findings of this particular study, in the hopes that future EPO work can make use of data in this report.

Maternal consumption of high-fat diet and grape juice modulates global histone H4 acetylation levels in offspring hippocampus: A preliminary study.

PubMed

Gonçalves, Luciana Kneib; da Silva, Ivy Reichert Vital; Cechinel, Laura Reck; Frusciante, Marina Rocha; de Mello, Alexandre Silva; Elsner, Viviane Rostirola; Funchal, Claudia; Dani, Caroline

2017-11-20

This study aimed to investigate the impact of maternal consumption of a hyperlipid diet and grape juice on global histone H4 acetylation levels in the offsprinǵs hippocampus at different stages of development. During pregnancy and lactation of offspring, dams were divided into 4 groups: control diet (CD), high-fat diet (HFD), control diet and purple grape juice (PGJCD) and purple grape juice and high-fat diet (PGJHFD). Male Wistar rats were euthanized at 21days of age (PN21, adolescents) and at 50days of age (PN50, adults). The maternal consumption of grape juice increased global histone H4 acetylation levels in hippocampus of adolescents pups (PN21), an indicative of enhanced transcriptional activity and increased gene expression. On the other hand, the maternal high-fat diet diminished significantly this epigenetic marker in the adult phase (PN50), suggesting gene silencing. These preliminary findings demonstrated that the maternal choices are able to induce changes on histone H4 acetylation status in hippocampus of the offspring, which may modulate the expression of specific genes. Interestingly, this response occurs in an age and stimuli-dependent manner and strongly reinforce the importance of maternal choices during gestation. Copyright © 2017 Elsevier B.V. All rights reserved.

Wave rotor demonstrator engine assessment

NASA Technical Reports Server (NTRS)

Snyder, Philip H.

1996-01-01

The objective of the program was to determine a wave rotor demonstrator engine concept using the Allison 250 series engine. The results of the NASA LERC wave rotor effort were used as a basis for the wave rotor design. A wave rotor topped gas turbine engine was identified which incorporates five basic requirements of a successful demonstrator engine. Predicted performance maps of the wave rotor cycle were used along with maps of existing gas turbine hardware in a design point study. The effects of wave rotor topping on the engine cycle and the subsequent need to rematch compressor and turbine sections in the topped engine were addressed. Comparison of performance of the resulting engine is made on the basis of wave rotor topped engine versus an appropriate baseline engine using common shaft compressor hardware. The topped engine design clearly demonstrates an impressive improvement in shaft horsepower (+11.4%) and SFC (-22%). Off design part power engine performance for the wave rotor topped engine was similarly improved including that at engine idle conditions. Operation of the engine at off design was closely examined with wave rotor operation at less than design burner outlet temperatures and rotor speeds. Challenges identified in the development of a demonstrator engine are discussed. A preliminary design was made of the demonstrator engine including wave rotor to engine transition ducts. Program cost and schedule for a wave rotor demonstrator engine fabrication and test program were developed.

Built-in active sensing diagnostic system for civil infrastructure systems

NASA Astrophysics Data System (ADS)

Wu, Fan; Chang, Fu-Kuo

2001-07-01

A reliable, robust monitoring system can improve the maintenance of and provide safety protection for civil structures and therefore prolong their service lives. A built-in, active sensing diagnostic technique for civil structures has been under investigation. In this technique, piezoelectric materials are used as sensors/actuators to receive and generate signals. The transducers are embedded in reinforced concrete (RC) beams and are designed to detect damage, particularly debonding damage between the reinforcing bars and concrete. This paper presents preliminary results from a feasibility study of the technology. Laboratory experiments performed on RC beams, with piezo-electric sensors and actuators mounted on reinforced steel bars, have clearly demonstrated that the proposed technique could detect debonding damage. Analytical work, using a special purpose finite-element software, PZFlex, was also conducted to interpret the relationship between the measured data and actual debonding damage. Effectiveness of the proposed technique for detecting debonding damage in civil structures has been demonstrated.