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Sample records for premarket applications pmas

  1. 76 FR 60055 - Draft Guidance for Industry: Applications for Premarket Review of New Tobacco Products...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-28

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry: Applications for Premarket Review of New Tobacco Products; Availability; Agency Information Collection Activities; Proposed... ``Applications for Premarket Review of New Tobacco Products.'' The draft guidance is intended to assist...

  2. 78 FR 19714 - User Fees and Refunds for Premarket Approval Applications and Device Biologics License...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-02

    ... HUMAN SERVICES Food and Drug Administration User Fees and Refunds for Premarket Approval Applications and Device Biologics License Applications; Guidance for Industry and Food and Drug Administration Staff; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food...

  3. 78 FR 53151 - The Applicability of Good Laboratory Practice in Premarket Device Submissions: Questions and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-28

    ... HUMAN SERVICES Food and Drug Administration The Applicability of Good Laboratory Practice in Premarket Device Submissions: Questions and Answers; Draft Guidance for Industry and Food and Drug Administration Staff; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food...

  4. 21 CFR 814.9 - Confidentiality of data and information in a premarket approval application (PMA) file.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES... the safety and effectiveness of the device that is the subject of the PMA and that is the basis for... under § 20.61; and (ii) Any personnel, medical, and similar information disclosure of which...

  5. 21 CFR 814.9 - Confidentiality of data and information in a premarket approval application (PMA) file.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES... the safety and effectiveness of the device that is the subject of the PMA and that is the basis for... under § 20.61; and (ii) Any personnel, medical, and similar information disclosure of which...

  6. Can You Diagnose Me Now? A Proposal to Modify FDA's Regulation of Smartphone Mobile Health Applications with a Pre-Market Notification and Application Database System.

    PubMed

    McInerney, Stephen

    2015-01-01

    Mobile applications provide limitless possibilities for the future of medical care. Yet these changes have also created concerns about patient safety. Under the Federal Food, Drug, and Cosmetic Act (FDCA), the Food and Drug Administration (FDA) has the authority to regulate a much broader spectrum of products beyond traditional medical devices like stethoscopes or pacemakers. The regulatory question is not if FDA has the statutory. authority to regulate health-related software, but rather how it will exercise its regulatory authority. In September 2013, FDA published guidance on Mobile Medical Applications; in it, the Agency limited its oversight to a small subset of medical-related mobile applications, referred to as "mobile medical applications." For the guidance to be effective, FDA must continue to work directly with all actors--including innovators, doctors, and patients--as the market for mobile health applications continues to develop. This Article argues that FDA should adopt a two-step plan--a pre-market notification program and a mobile medical application database--to aid in the successful implementation of its 2013 guidance. By doing so, FDA will ensure that this burgeoning market can reach its fullest potential.

  7. 76 FR 48058 - Effective Date of Requirement for Premarket Approval for Cardiovascular Permanent Pacemaker...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-08

    ... premarket approval application (PMA) or a notice of completion of a product development protocol (PDP) for... requirement for premarket approval applications or product development protocols for cardiovascular permanent... progress reports and records of the trials conducted under the protocol on the safety and effectiveness...

  8. 76 FR 53851 - Effective Date of Requirement for Premarket Approval for Cardiovascular Permanent Pacemaker...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ... proposed to require the filing of a premarket approval application or a notice of completion of a product development protocol for the class III preamendments device: Cardiovascular permanent pacemaker electrode....

  9. FDA's misplaced priorities: premarket review under the Family Smoking Prevention and Tobacco Control Act.

    PubMed

    Jenson, Desmond; Lester, Joelle; Berman, Micah L

    2016-05-01

    Among other key objectives, the 2009 Family Smoking Prevention and Tobacco Control Act was designed to end an era of constant product manipulation by the tobacco industry that had led to more addictive and attractive products. The law requires new tobacco products to undergo premarket review by the US Food and Drug Administration (FDA) before they can be sold. To assess FDA's implementation of its premarket review authorities, we reviewed FDA actions on new product applications, publicly available data on industry applications to market new products, and related FDA guidance documents and public statements. We conclude that FDA has not implemented the premarket review process in a manner that prioritises the protection of public health. In particular, FDA has (1) prioritised the review of premarket applications that allow for the introduction of new tobacco products over the review of potentially non-compliant products that are already on the market; (2) misallocated resources by accommodating the industry's repeated submissions of deficient premarket applications and (3) weakened the premarket review process by allowing the tobacco industry to market new and modified products that have not completed the required review process.

  10. Analysis of the safety evaluation for premarketing clinical trials of hemodialyzer and of postmarketing safety reports of hemodialyzer in Japan and the US: insights into the construction of a sophisticated premarketing evaluation.

    PubMed

    Saito, Masami; Iwasaki, Kiyotaka

    2017-03-01

    Our aim was to conduct a scoping review of the regulations for hemodialyzers in the safety evaluation in Japan and the United States, and to evaluate the criteria for premarketing clinical trials and postmarketing safety reports to inform the development of a sophisticated premarketing evaluation in Japan. Regulations for approval of hemodialyzers were identified from the databases of the Ministry of Health, Labor and Welfare in Japan and the Federal Drug Agency (FDA) in the United States (US). The criteria for premarket clinical trials and postmarketing safety reports were evaluated for both countries. Standards in Japan required evaluation of blood compatibility and reporting of acute adverse effects by a premarketing clinical trial in 6 of 86 applications with semipermeable membrane materials deemed to be different to those of previously approved devices from 1983 to 31 August 2015. By comparison, the clinical trial was required in one of 545 approvals in the US from 1976 to 29 January 2016, but blood compatibility was not the point. All postmarketing adverse effects identified in Japan were included in the set of 'warnings'. The more stringent requirements for evaluation of blood compatibility and acute adverse effects in Japan seemed to be related to differences in the history of quality management systems for medical devices between the two countries. This study revealed that there were differences between Japan and the US in requiring the premarketing clinical trials for the hemodialyzers. Our findings could be useful for constructing sophisticated premarketing safety evaluation.

  11. 78 FR 20268 - Effective Date of Requirement for Premarket Approval for Three Class III Preamendments Devices...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    ...The Food and Drug Administration (FDA) is issuing a proposed administrative order to require the filing of a premarket approval application (PMA) or a notice of completion of a product development protocol (PDP) for the following three class III preamendments devices: Sorbent hemoperfusion devices for the treatment of hepatic coma and metabolic disturbances; cranial electrotherapy stimulator......

  12. 76 FR 50663 - Effective Date of Requirement for Premarket Approval for Three Class III Preamendments Devices

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-16

    ... the filing of a premarket approval application (PMA) or a notice of completion of a product development protocol (PDP) for the following three class III preamendments devices: Ventricular bypass (assist... current (2010) Implicit Price Deflator for the Gross Domestic Product. FDA does not expect this final...

  13. 76 FR 78930 - Guidance for Industry and Food and Drug Administration Staff; Enforcement Policy for Premarket...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ...; Enforcement Policy for Premarket Notification Requirements for Certain In Vitro Diagnostic and Radiology... for Premarket Notification Requirements for Certain In Vitro Diagnostic and Radiology Devices.'' This... for certain in vitro diagnostic and radiology devices under the regulations. DATES: Submit...

  14. 78 FR 44128 - Agency Information Collection Activities; Proposed Collection; Comment Request; Premarket...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... into class III by FDA are subject to premarket approval requirements. Premarket approval (PMA) is the... preamendments class III devices are subject to the same requirements as the preamendments devices. FDA... affect the safety and effectiveness of a device subject to an approved PMA do not require submission of...

  15. 21 CFR 170.101 - Information in a premarket notification for a food contact substance (FCN).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Information in a premarket notification for a food contact substance (FCN). 170.101 Section 170.101 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD ADDITIVES Premarket Notifications § 170.101...

  16. 21 CFR 170.104 - Action on a premarket notification for a food contact substance (FCN).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD ADDITIVES Premarket Notifications § 170.104 Action on a.... (d) If FDA and a manufacturer or supplier agree that the notifier may submit a food additive petition... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Action on a premarket notification for a...

  17. Medical devices; exemptions from premarket notification and reserved devices; class I--FDA. Notice.

    PubMed

    1998-02-02

    The Food and Drug Administration (FDA) is publishing a list of class I devices, subject to certain limitations, that will be exempt from premarket notification requirements on February 19, 1998. FDA is also publishing a list of those class I devices that FDA believes will remain subject to premarket notification requirements because they meet the new statutory criteria for premarket notification requirements. These lists do not include class I devices that have been previously exempted by regulation from the premarket notification requirements. FDA is taking this action in order to meet a requirement of the Food and Drug Administration Modernization Act of 1997 (the FDAMA). The agency requests comments on whether the list of class I devices that will remain subject to the premarket notification requirements should be modified.

  18. 21 CFR 814.20 - Application.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... PREMARKET APPROVAL OF MEDICAL DEVICES Premarket Approval Application (PMA) § 814.20 Application. Link to an... number for each item referred to in the table. A PMA shall include separate sections on nonclinical... information that it believes to be trade secret or confidential commercial or financial information in...

  19. 78 FR 52773 - Agency Information Collection Activities; Proposed Collection; Comment Request; Premarket...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-26

    ... HUMAN SERVICES Food and Drug Administration Agency Information Collection Activities; Proposed Collection; Comment Request; Premarket Notification for a New Dietary Ingredient AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA or we) is announcing...

  20. Medical devices; exemption from premarket notification and reserved devices; Class I--FDA. Proposed rule.

    PubMed

    1998-11-12

    The Food and Drug Administration (FDA) is proposing to amend its classification regulations to designate class I devices that are exempt from the premarket notification requirements, subject to certain limitations, and to designate those class I devices that remain subject to premarket notification requirements under the new statutory criteria for premarket notification requirements. The devices FDA is proposing to designate as exempt do not include class I devices that have been previously exempted by regulation from the premarket notification requirements. This action is being taken under the Federal Food, Drug, and Cosmetic Act (the act), as amended by the Medical Device Amendments of 1976 (the 1976 amendments), the Safe Medical Devices Act of 1990 (SMDA), and the Food and Drug Administration Modernization Act of 1997 (FDAMA). FDA is taking this action in order to implement a requirement of FDAMA.

  1. 78 FR 35940 - Content of Premarket Submissions for Management of Cybersecurity in Medical Devices; Draft...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-14

    ... HUMAN SERVICES Food and Drug Administration Content of Premarket Submissions for Management of Cybersecurity in Medical Devices; Draft Guidance for Industry and Food and Drug Administration Staff; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and...

  2. 77 FR 48160 - Division of Cardiovascular Devices 30-Day Notices and Annual Reports; Public Workshop; Request...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-13

    ... following public workshop entitled ``Division of Cardiovascular Devices 30-Day Notices and Annual Reports... requirements applicable to premarket approval applications (PMAs), 30-day notices and annual reports... periodic (annual) report. This workshop is intended to focus on manufacturing method and procedure...

  3. 21 CFR 170.100 - Submission of a premarket notification for a food contact substance (FCN) to the Food and Drug...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... CONSUMPTION (CONTINUED) FOOD ADDITIVES Premarket Notifications § 170.100 Submission of a premarket... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Submission of a premarket notification for a food contact substance (FCN) to the Food and Drug Administration (FDA). 170.100 Section 170.100 Food and...

  4. 21 CFR 170.100 - Submission of a premarket notification for a food contact substance (FCN) to the Food and Drug...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... CONSUMPTION (CONTINUED) FOOD ADDITIVES Premarket Notifications § 170.100 Submission of a premarket... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Submission of a premarket notification for a food contact substance (FCN) to the Food and Drug Administration (FDA). 170.100 Section 170.100 Food and...

  5. 21 CFR 170.100 - Submission of a premarket notification for a food contact substance (FCN) to the Food and Drug...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... CONSUMPTION (CONTINUED) FOOD ADDITIVES Premarket Notifications § 170.100 Submission of a premarket... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Submission of a premarket notification for a food contact substance (FCN) to the Food and Drug Administration (FDA). 170.100 Section 170.100 Food and...

  6. 21 CFR 170.100 - Submission of a premarket notification for a food contact substance (FCN) to the Food and Drug...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... CONSUMPTION (CONTINUED) FOOD ADDITIVES Premarket Notifications § 170.100 Submission of a premarket... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Submission of a premarket notification for a food contact substance (FCN) to the Food and Drug Administration (FDA). 170.100 Section 170.100 Food and...

  7. 21 CFR 170.102 - Confidentiality of information in a premarket notification for a food contact substance (FCN).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Confidentiality of information in a premarket notification for a food contact substance (FCN). 170.102 Section 170.102 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD ADDITIVES Premarket Notifications §...

  8. 21 CFR 170.105 - The Food and Drug Administration's (FDA's) determination that a premarket notification for a food...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVES Premarket Notifications § 170.105 The Food... 21 Food and Drugs 3 2013-04-01 2013-04-01 false The Food and Drug Administration's (FDA's) determination that a premarket notification for a food contact substance (FCN) is no longer effective....

  9. 21 CFR 170.105 - The Food and Drug Administration's (FDA's) determination that a premarket notification for a food...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVES Premarket Notifications § 170.105 The Food... 21 Food and Drugs 3 2011-04-01 2011-04-01 false The Food and Drug Administration's (FDA's) determination that a premarket notification for a food contact substance (FCN) is no longer effective....

  10. 21 CFR 170.103 - Withdrawal without prejudice of a premarket notification for a food contact substance (FCN).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Withdrawal without prejudice of a premarket notification for a food contact substance (FCN). 170.103 Section 170.103 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD ADDITIVES Premarket Notifications §...

  11. 21 CFR 170.105 - The Food and Drug Administration's (FDA's) determination that a premarket notification for a food...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVES Premarket Notifications § 170.105 The Food... 21 Food and Drugs 3 2012-04-01 2012-04-01 false The Food and Drug Administration's (FDA's) determination that a premarket notification for a food contact substance (FCN) is no longer effective....

  12. 21 CFR 170.105 - The Food and Drug Administration's (FDA's) determination that a premarket notification for a food...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVES Premarket Notifications § 170.105 The Food... 21 Food and Drugs 3 2010-04-01 2009-04-01 true The Food and Drug Administration's (FDA's) determination that a premarket notification for a food contact substance (FCN) is no longer effective....

  13. 21 CFR 170.105 - The Food and Drug Administration's (FDA's) determination that a premarket notification for a food...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... (CONTINUED) FOOD ADDITIVES Premarket Notifications § 170.105 The Food and Drug Administration's (FDA's... 21 Food and Drugs 3 2014-04-01 2014-04-01 false The Food and Drug Administration's (FDA's) determination that a premarket notification for a food contact substance (FCN) is no longer effective....

  14. Medical devices; exemption from premarket notification and reserved devices; class I. Food and Drug Administration, HHS. Final rule.

    PubMed

    2000-01-14

    The Food and Drug Administration (FDA) is amending its classification regulations to designate class I devices that are exempt from the premarket notification requirements, subject to certain limitations, and to designate those class I devices that remain subject to premarket notification requirements under the new statutory criteria for premarket notification requirements. The devices FDA is designating as exempt do not include class I devices that have been previously exempted by regulation from the premarket notification requirements. This action is being taken under the Federal Food, Drug, and Cosmetic Act (the act), as amended by the Medical Device Amendments of 1976 (the 1976 amendments), the Safe Medical Devices Act of 1990 (SMDA), and the FDA Modernization Act of 1997 (FDAMA). FDA is taking this action in order to implement a requirement of FDAMA. Elsewhere in this issue of the Federal Register, FDA is announcing that it is withdrawing proposed rules to revoke existing exemptions from premarket notification for two devices.

  15. Cardiovascular devices; reclassification of nonroller-type cardiopulmonary bypass blood pumps for cardiopulmonary and circulatory bypass; effective date of requirement for premarket approval for nonroller-type cardiopulmonary bypass blood pumps for temporary ventricular support. Final order.

    PubMed

    2015-06-08

    The Food and Drug Administration (FDA) is issuing a final order to reclassify nonroller-type cardiopulmonary bypass blood pump (NRP) devices for cardiopulmonary and circulatory bypass, a preamendments class III device, into class II (special controls), and to require the filing of a premarket approval application (PMA) for NRP devices for temporary ventricular support. FDA is also revising the title and identification of the regulation for NRP devices in this order.

  16. 77 FR 15779 - Medical Devices; Availability of Safety and Effectiveness Summaries for Premarket Approval...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-16

    ...-2011-M-0917] Medical Devices; Availability of Safety and Effectiveness Summaries for Premarket Approval..., FDA-2011-M-0791 Medtronic Ireland.... ASSURANT COBALT October 26, 2011. iliac balloon- expandable... November 2, 2011. LLC. transcatheter heart valve and RETROFLEX 3 delivery system, RETROFLEX...

  17. 21 CFR 866.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Effective dates of requirement for premarket approval. 866.3 Section 866.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES General Provisions §...

  18. 21 CFR 866.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Effective dates of requirement for premarket approval. 866.3 Section 866.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES General Provisions §...

  19. 21 CFR 866.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Effective dates of requirement for premarket approval. 866.3 Section 866.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES General Provisions §...

  20. 21 CFR 866.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Effective dates of requirement for premarket approval. 866.3 Section 866.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES General Provisions §...

  1. 21 CFR 866.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Effective dates of requirement for premarket approval. 866.3 Section 866.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES General Provisions §...

  2. 21 CFR 864.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Effective dates of requirement for premarket approval. 864.3 Section 864.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES General Provisions § 864.3...

  3. 21 CFR 864.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Effective dates of requirement for premarket approval. 864.3 Section 864.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES General Provisions § 864.3...

  4. The inadequacies of pre-market chemical risk assessment's toxicity studies-the implications.

    PubMed

    Tweedale, Anthony C

    2017-01-01

    Industry provides essentially all the data for most (pre-market) chemical risk assessments (RA); academics study a chemical once it is marketed. For two randomly-chosen high production chemicals, despite new European Union mandates to evaluate all data, just 13% of the herbicide bentazon and 15% of the flame-retardant hexabromocyclododecane's published toxicity studies were found in their pre-market RA, and a systematic review on bentazon concludes it has greater hazards than indicated in its RA. More important, for both, academia's toxicity studies were designated as lower quality than industries were, despite showing hazards at lower doses. The accuracy of industry's test methods is analyzed and found to be replicable but insensitive, thus inaccurate. The synthetic pharmaceutical industry originated them, and by 1983 the Organization for Economic Cooperation & Development mandated their test guidelines (TG) methods be accepted for any new study for pre-market RA. For existing studies, industry's "Klimisch" criterion is universally used to evaluate quality, but it only states that TG studies produce the best data. However, no TG can answer the realistic exposure effect hypotheses of academics; therefore, crucially in pre-market RA, tens of thousands of published experimental findings (increasingly at low dose) are ignored to determine the safe dose. Few appreciate this, so scientific debate on the most accurate elements of toxicity tests is urgently indicated. Copyright © 2016 John Wiley & Sons, Ltd.

  5. 21 CFR 868.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Effective dates of requirement for premarket approval. 868.3 Section 868.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES ANESTHESIOLOGY DEVICES General Provisions § 868.3 Effective dates...

  6. 21 CFR 807.100 - FDA action on a premarket notification.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (CONTINUED) MEDICAL DEVICES ESTABLISHMENT REGISTRATION AND DEVICE LISTING FOR MANUFACTURERS AND INITIAL...) After review of a premarket notification, FDA will: (1) Issue an order declaring the device to be... information, including clinical data if deemed necessary by the Commissioner, that demonstrates that...

  7. 21 CFR 864.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Effective dates of requirement for premarket approval. 864.3 Section 864.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES General Provisions § 864.3...

  8. 21 CFR 864.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Effective dates of requirement for premarket approval. 864.3 Section 864.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES General Provisions § 864.3...

  9. 21 CFR 864.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Effective dates of requirement for premarket approval. 864.3 Section 864.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES General Provisions § 864.3...

  10. 21 CFR 878.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Effective dates of requirement for premarket approval. 878.3 Section 878.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES General Provisions §...

  11. 21 CFR 878.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Effective dates of requirement for premarket approval. 878.3 Section 878.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES General Provisions §...

  12. 21 CFR 170.101 - Information in a premarket notification for a food contact substance (FCN).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Information in a premarket notification for a food contact substance (FCN). 170.101 Section 170.101 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD...

  13. 21 CFR 170.101 - Information in a premarket notification for a food contact substance (FCN).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Information in a premarket notification for a food contact substance (FCN). 170.101 Section 170.101 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD...

  14. 21 CFR 170.104 - Action on a premarket notification for a food contact substance (FCN).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVES... agree that the notifier may submit a food additive petition proposing the approval of the food contact... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Action on a premarket notification for a...

  15. 21 CFR 170.104 - Action on a premarket notification for a food contact substance (FCN).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVES... agree that the notifier may submit a food additive petition proposing the approval of the food contact... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Action on a premarket notification for a...

  16. 21 CFR 170.104 - Action on a premarket notification for a food contact substance (FCN).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVES... agree that the notifier may submit a food additive petition proposing the approval of the food contact... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Action on a premarket notification for a...

  17. 21 CFR 170.104 - Action on a premarket notification for a food contact substance (FCN).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVES... agree that the notifier may submit a food additive petition proposing the approval of the food contact... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Action on a premarket notification for a...

  18. 21 CFR 170.101 - Information in a premarket notification for a food contact substance (FCN).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Information in a premarket notification for a food contact substance (FCN). 170.101 Section 170.101 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD...

  19. 21 CFR 170.101 - Information in a premarket notification for a food contact substance (FCN).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Information in a premarket notification for a food contact substance (FCN). 170.101 Section 170.101 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD...

  20. 77 FR 39924 - Effective Date of Requirement for Premarket Approval for Cardiovascular Permanent Pacemaker...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-06

    ... device to meet the statute's approval requirements and the benefits to the public from the use of the... benefit to the public from the use of the device; (3) an opportunity for the submission of comments on the... premarket approval requirements of the FD&C Act, and the benefits to the public from use of the device....

  1. 21 CFR 874.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... SERVICES (CONTINUED) MEDICAL DEVICES EAR, NOSE, AND THROAT DEVICES General Provisions § 874.3 Effective dates of requirement for premarket approval. A device included in this part that is classified into... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Effective dates of requirement for...

  2. 21 CFR 874.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... SERVICES (CONTINUED) MEDICAL DEVICES EAR, NOSE, AND THROAT DEVICES General Provisions § 874.3 Effective dates of requirement for premarket approval. A device included in this part that is classified into... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Effective dates of requirement for...

  3. 77 FR 32642 - Medical Devices; Exemption From Premarket Notification: Powered Patient Transport

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ...): Division of Dockets Management (HFA-305), Food and Drug Administration, 5630 Fishers Lane, Rm. 1061... through the premarket notification process under section 510(k) of the FD&C Act (21 U.S.C. 360(k)). Section 510(k) of the FD&C Act and the implementing regulations, 21 CFR part 807, require persons...

  4. 77 FR 32644 - Medical Devices; Exemption From Premarket Notification: Wheelchair Elevator

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ... paper, disk, or CD-ROM submissions): Division of Dockets Management (HFA-305), Food and Drug... under section 510(k) of the FD&C Act (21 U.S.C. 360(k)). Section 510(k) of the FD&C Act and the... premarket notification (510(k)) containing information that allows FDA to determine whether the new...

  5. 21 CFR 892.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Effective dates of requirement for premarket approval. 892.3 Section 892.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES General Provisions § 892.3 Effective dates...

  6. 21 CFR 892.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Effective dates of requirement for premarket approval. 892.3 Section 892.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES General Provisions § 892.3 Effective dates...

  7. 21 CFR 892.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Effective dates of requirement for premarket approval. 892.3 Section 892.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES General Provisions § 892.3 Effective dates...

  8. 21 CFR 892.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Effective dates of requirement for premarket approval. 892.3 Section 892.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES General Provisions § 892.3 Effective dates...

  9. 21 CFR 892.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Effective dates of requirement for premarket approval. 892.3 Section 892.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES General Provisions § 892.3 Effective dates...

  10. 21 CFR 874.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Effective dates of requirement for premarket approval. 874.3 Section 874.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES EAR, NOSE, AND THROAT DEVICES General Provisions § 874.3...

  11. 21 CFR 874.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Effective dates of requirement for premarket approval. 874.3 Section 874.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES EAR, NOSE, AND THROAT DEVICES General Provisions § 874.3...

  12. 21 CFR 874.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Effective dates of requirement for premarket approval. 874.3 Section 874.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES EAR, NOSE, AND THROAT DEVICES General Provisions § 874.3...

  13. 21 CFR 890.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Effective dates of requirement for premarket approval. 890.3 Section 890.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES General Provisions § 890.3 Effective...

  14. 21 CFR 890.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Effective dates of requirement for premarket approval. 890.3 Section 890.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES General Provisions § 890.3 Effective...

  15. 21 CFR 878.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Effective dates of requirement for premarket approval. 878.3 Section 878.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES General Provisions §...

  16. 21 CFR 878.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Effective dates of requirement for premarket approval. 878.3 Section 878.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES General Provisions §...

  17. 21 CFR 878.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Effective dates of requirement for premarket approval. 878.3 Section 878.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES General Provisions §...

  18. 21 CFR 888.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... requirement for premarket approval. A device included in this part that is classified into class III... day of the 30th full calendar month after the regulation that classifies the device into class III is..., is classified by statute (section 513(f) of the act) into class III without any grace period and...

  19. 21 CFR 886.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... requirement for premarket approval. A device included in this part that is classified into class III... day of the 30th full calendar month after the regulation that classifies the device into class III is..., is classified by statute (section 513(f) of the act) into class III without any grace period and...

  20. 21 CFR 872.3 - Effective dates of requirement for premarket approval.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... requirement for premarket approval. A device included in this part that is classified into class III... day of the 30th full calendar month after the regulation that classifies the device into class III is..., is classified by statute (section 513(f) of the act) into class III without any grace period and...

  1. Orthopaedic Device Approval Through the Premarket Approval Process: A Financial Feasibility Analysis for a Single Center.

    PubMed

    Yang, Brian W; Iorio, Matthew L; Day, Charles S

    2017-03-15

    The 2 main routes of medical device approval through the U.S. Food and Drug Administration are the premarket approval (PMA) process, which requires clinical trials, and the 510(k) premarket notification, which exempts devices from clinical trials if they are substantially equivalent to an existing device. Recently, there has been growing concern regarding the safety of devices approved through the 510(k) premarket notification. The PMA process decreases the potential for device recall; however, it is substantially more costly and time-consuming. Investors and medical device companies are only willing to invest in devices if they can expect to recoup their investment within a timeline of roughly 7 years. Our study utilizes financial modeling to assess the financial feasibility of approving various orthopaedic medical devices through the 510(k) and PMA processes. The expected time to recoup investment through the 510(k) process ranged from 0.585 years to 7.715 years, with an average time of 2.4 years; the expected time to recoup investment through the PMA route ranged from 2.9 years to 24.5 years, with an average time of 8.5 years. Six of the 13 orthopaedic device systems that we analyzed would require longer than our 7-year benchmark to recoup the investment costs of the PMA process. With the 510(k) premarket notification, only 1 device system would take longer than 7 years to recoup its investment costs. Although the 510(k) premarket notification has demonstrated safety concerns, broad requirements for PMA authorization may limit device innovation for less-prevalent orthopaedic conditions. As a result, new approval frameworks may be beneficial. Our report demonstrates how current regulatory policies can potentially influence orthopaedic device innovation.

  2. 78 FR 14097 - Pulse Oximeters-Premarket Notification Submissions [510(k)s]; Guidance for Industry and Food and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-04

    ... current thinking in regards to information that should be included in a premarket submission for a non... guidance represents the Agency's current thinking on non-invasive pulse oximeters intended for...

  3. Designing premarket observational comparative studies using existing data as controls: challenges and opportunities.

    PubMed

    Yue, Lilly Q; Lu, Nelson; Xu, Yunling

    2014-01-01

    Due to the special nature of medical device clinical studies, observational (nonrandomized) comparative studies play important roles in the premarket safety/effectiveness evaluation of medical devices. While historical data collected in earlier investigational device exemption studies of a previously approved medical device have been used to form control groups in comparative studies, high-quality registry data are emerging to provide opportunities for the premarket evaluation of new devices. However, in such studies, various biases could be introduced in every stage and aspect of study and may compromise the objectivity of study design and validity of study results. In this article, challenges and opportunities in the design of such studies using propensity score methodology are discussed from regulatory perspectives.

  4. EARLY EVALUATION OF NEW HEALTH TECHNOLOGIES: THE CASE FOR PREMARKET STUDIES THAT HARMONIZE REGULATORY AND COVERAGE PERSPECTIVES.

    PubMed

    Levin, Leslie

    2015-01-01

    With an increasing awareness that active engagement between policy decision makers, HTA agencies, regulators and payers with industry in the premarket space is needed, a disruptive comprehensive approach is described which moves the evidentiary process exclusively into this space. Single harmonized studies pre-market to address regulatory and coverage needs and expectations are more likely to be efficient and less costly and position evidence to drive rather than test innovation. An example of such a process through the MaRS EXCITE program in Ontario, Canada, now undergoing proof of concept, is briefly discussed. Other examples of dialogue between decision makers and industry pre-market are provided though these are less robust than a comprehensive evidentiary approach.

  5. A pre-marketing ALT signal predicts post-marketing liver safety.

    PubMed

    Moylan, Cynthia A; Suzuki, Ayako; Papay, Julie I; Yuen, Nancy A; Ames, Michael; Hunt, Christine M

    2012-08-01

    Drug induced liver injury during drug development is evidenced by a higher incidence of serum alanine aminotransferase (ALT) elevations in treated versus placebo populations and termed an "ALT signal". We sought to quantify whether an ALT signal in pre-marketing clinical trials predicted post-marketing hepatotoxicity. Incidence of ALT elevations (ALT ≥ 3 times upper limits normal [× ULN]) for drug and placebo of new chemical entities and approved drugs associated with hepatotoxicity was calculated using the Food and Drug Administration (FDA) website. Post-marketing liver safety events were identified using the FDA Adverse Event Reporting System (AERS). The association of FDA AERS signal score (EB05 ≥ 2) and excess risk of pre-marketing ALT elevation (difference in incidence of ALT ≥ 3× ULN in treated versus placebo) was examined. An ALT signal of ≥ 1.2% was significantly associated with a post-marketing liver safety signal (p ≤ 0.013) and a 71.4% positive predictive value. An absent ALT signal was associated with a high likelihood of post-marketing liver safety; negative predictive value of 89.7%. Daily drug dose information improved the prediction of post-marketing liver safety. A cut-off of 1.2% increase in ALT ≥ 3× ULN in treated versus placebo groups provides an easily calculated method for predicting post-marketing liver safety.

  6. Cardiovascular devices; reclassification of intra-aortic balloon and control systems for acute coronary syndrome, cardiac and non-cardiac surgery, or complications of heart failure; effective date of requirement for premarket approval for intra-aortic balloon and control systems for septic shock or pulsatile flow generation. Final order.

    PubMed

    2013-12-30

    The Food and Drug Administration (FDA) is issuing a final order to reclassify intra-aortic balloon and control system (IABP) devices when indicated for acute coronary syndrome, cardiac and non-cardiac surgery, or complications of heart failure, a preamendments class III device, into class II (special controls), and to require the filing of a premarket approval application (PMA) or a notice of completion of a product development protocol (PDP) for IABPs when indicated for septic shock or pulsatile flow generation.

  7. 21 CFR 170.103 - Withdrawal without prejudice of a premarket notification for a food contact substance (FCN).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Withdrawal without prejudice of a premarket notification for a food contact substance (FCN). 170.103 Section 170.103 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED)...

  8. 21 CFR 170.103 - Withdrawal without prejudice of a premarket notification for a food contact substance (FCN).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Withdrawal without prejudice of a premarket notification for a food contact substance (FCN). 170.103 Section 170.103 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED)...

  9. 21 CFR 170.102 - Confidentiality of information in a premarket notification for a food contact substance (FCN).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Confidentiality of information in a premarket notification for a food contact substance (FCN). 170.102 Section 170.102 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED)...

  10. 21 CFR 170.102 - Confidentiality of information in a premarket notification for a food contact substance (FCN).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Confidentiality of information in a premarket notification for a food contact substance (FCN). 170.102 Section 170.102 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED)...

  11. 21 CFR 170.102 - Confidentiality of information in a premarket notification for a food contact substance (FCN).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Confidentiality of information in a premarket notification for a food contact substance (FCN). 170.102 Section 170.102 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED)...

  12. 21 CFR 170.103 - Withdrawal without prejudice of a premarket notification for a food contact substance (FCN).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Withdrawal without prejudice of a premarket notification for a food contact substance (FCN). 170.103 Section 170.103 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED)...

  13. 21 CFR 170.103 - Withdrawal without prejudice of a premarket notification for a food contact substance (FCN).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Withdrawal without prejudice of a premarket notification for a food contact substance (FCN). 170.103 Section 170.103 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED)...

  14. 21 CFR 170.102 - Confidentiality of information in a premarket notification for a food contact substance (FCN).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Confidentiality of information in a premarket notification for a food contact substance (FCN). 170.102 Section 170.102 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED)...

  15. 75 FR 14602 - Guidance for Industry on Drug-Induced Liver Injury: Premarketing Clinical Evaluation; Opening of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-26

    ... HUMAN SERVICES Food and Drug Administration (formerly Docket No. FDA-2008-D-0128) Guidance for Industry on Drug-Induced Liver Injury: Premarketing Clinical Evaluation; Opening of Comment Period for Future Revision of Guidance Dated July 2009; Public Conference AGENCY: Food and Drug Administration, HHS....

  16. [Do premarketing trials help to predict drug-related iatrogenic effects in elderly patients?].

    PubMed

    Bouvenot, Gilles; Villani, Patrick

    2004-01-01

    Premarketing trials contribute poorly to predicting drug-related iatrogenic effects in elderly patients. Since their main goal is the demonstration of drug efficacy, these trials are characterised by a simplistic design, they include a limited number of young participants (volunteers only), are of a short duration, and follow a strict protocol. Results of studies in young people cannot be extrapolated to elderly people. Although licensing authorities recommend the recruitment of a meaningful number of elderly people in clinical trials (with an age distribution comparable to that expected when the drug is in routine use), even in trials that are not devoted to geriatric illnesses, elderly people remain substantially under-represented in most instances for methodological reasons (to avoid increased variance introduced by a heterogenous population), safety reasons (at this stage of drug development, it could be deleterious to include patients with comorbid conditions and unfair with regard to the brand image of the products), and ethical reasons (the decision to participate could not be taken by the elderly people alone). Exclusion of elderly participants, who are particularly exposed to drug-related iatrogenic effects, influences the generalisability of study findings. The recruitment of elderly participants, a vulnerable population, is necessary to allow valid conclusions regarding elderly people, recommendations on the appropriate dosage adjustment for elderly individuals, the avoidance of prescribing decisions based on inadequate information (with respect to a more informative summary of the characteristics of the products), and the maximum benefit for elderly people from research.

  17. The practice of pre-marketing safety assessment in drug development.

    PubMed

    Chuang-Stein, Christy; Xia, H Amy

    2013-01-01

    The last 15 years have seen a substantial increase in efforts devoted to safety assessment by statisticians in the pharmaceutical industry. While some of these efforts were driven by regulations and public demand for safer products, much of the motivation came from the realization that there is a strong need for a systematic approach to safety planning, evaluation, and reporting at the program level throughout the drug development life cycle. An efficient process can help us identify safety signals early and afford us the opportunity to develop effective risk minimization plan early in the development cycle. This awareness has led many pharmaceutical sponsors to set up internal systems and structures to effectively conduct safety assessment at all levels (patient, study, and program). In addition to process, tools have emerged that are designed to enhance data review and pattern recognition. In this paper, we describe advancements in the practice of safety assessment during the premarketing phase of drug development. In particular, we share examples of safety assessment practice at our respective companies, some of which are based on recommendations from industry-initiated working groups on best practice in recent years.

  18. Premarket assessment of devices for treatment of critical limb ischemia: the role of Objective Performance Criteria and Goals.

    PubMed

    Geraghty, Patrick J; Matsumura, Jon S; Conte, Michael S

    2009-12-01

    Medical devices are cleared for marketing approval through the Food and Drug Administration (FDA). Unique statutory requirements, such as the "least burdensome mandate," have allowed the FDA to employ non-concurrent controls in its evaluation of prospective therapies. The use of Objective Performance Criteria and Goals (OPC and OPG) for the premarket evaluation of cardiovascular devices has become established as an alternative to randomized, controlled trials (RCTs). These single-armed comparisons may facilitate rapid entry of novel devices to the market. Unlike RCTs, they do not establish superiority or non-inferiority of the examined therapy, and study populations must be carefully inspected to ensure validity of comparisons to historical controls.

  19. Clinical Evidence Supporting US Food and Drug Administration Premarket Approval of High-Risk Otolaryngologic Devices, 2000-2014.

    PubMed

    Rathi, Vinay K; Wang, Bo; Ross, Joseph S; Downing, Nicholas S; Kesselheim, Aaron S; Gray, Stacey T

    2017-02-01

    The US Food and Drug Administration (FDA) approves high-risk medical devices based on premarket pivotal clinical studies demonstrating reasonable assurance of safety and effectiveness and may require postapproval studies (PAS) to further inform benefit-risk assessment. We conducted a cross-sectional analysis using publicly available FDA documents to characterize industry-sponsored pivotal studies and PAS of high-risk devices used in the treatment of otolaryngologic diseases. Between 2000 and 2014, the FDA approved 23 high-risk otolaryngologic devices based on 28 pivotal studies. Median enrollment was 118 patients (interquartile range, 67-181), and median duration of longest primary effectiveness end point follow-up was 26 weeks (interquartile range, 16-96). Fewer than half were randomized (n = 13, 46%), blinded (n = 12, 43%), or controlled (n = 10, 36%). The FDA required 23 PASs for 16 devices (70%): almost two-thirds (n = 15, 65%) monitored long-term performance, and roughly one-third (n = 8, 35%) focused on subgroups. Otolaryngologists should be aware of limitations in the strength of premarket evidence when considering the use of newly approved devices.

  20. 21 CFR 170.100 - Submission of a premarket notification for a food contact substance (FCN) to the Food and Drug...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Submission of a premarket notification for a food contact substance (FCN) to the Food and Drug Administration (FDA). 170.100 Section 170.100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD...

  1. Information Regarding the OraQuick In-Home HIV Test

    MedlinePlus

    ... test? Information on the OraQuick In-Home HIV Test can be found on FDA’s website . Additionally, information can be obtained from the manufacturer, OraSure Technologies. back to top More in Premarket Approvals (PMAs) ...

  2. 21 CFR 814.108 - Supplemental applications.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Supplemental applications. 814.108 Section 814.108 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Humanitarian Use Devices § 814.108...

  3. 21 CFR 814.108 - Supplemental applications.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Supplemental applications. 814.108 Section 814.108 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Humanitarian Use Devices § 814.108...

  4. 21 CFR 814.108 - Supplemental applications.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Supplemental applications. 814.108 Section 814.108 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Humanitarian Use Devices § 814.108...

  5. 21 CFR 814.108 - Supplemental applications.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Supplemental applications. 814.108 Section 814.108 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Humanitarian Use Devices § 814.108...

  6. Time Series Analysis of the Effectiveness and Safety of Capsule Endoscopy between the Premarketing and Postmarketing Settings: A Meta-Analysis

    PubMed Central

    Iijima, Kazuo; Umezu, Mitsuo; Iwasaki, Kiyotaka

    2016-01-01

    Background Clinical studies for assessing the effectiveness and safety in a premarketing setting are conducted under time and cost constraints. In recent years, postmarketing data analysis has been given more attention. However, to our knowledge, no studies have compared the effectiveness and the safety between the pre- and postmarketing settings. In this study, we aimed to investigate the importance of the postmarketing data analysis using clinical data. Methods and Findings Studies on capsule endoscopy with rich clinical data in both pre- and postmarketing settings were selected for the analysis. For effectiveness, clinical studies published before October 10, 2015 comparing capsule endoscopy and conventional flexible endoscopy measuring the detection ratio of obscure gastrointestinal bleeding were selected (premarketing: 4 studies and postmarketing: 8 studies) from PubMed (MEDLINE), Cochrane Library, EMBASE and Web of Science. Among the 12 studies, 5 were blinded and 7 were non-blinded. A time series meta-analysis was conducted. Effectiveness (odds ratio) decreased in the postmarketing setting (premarketing: 5.19 [95% confidence interval: 3.07–8.76] vs. postmarketing: 1.48 [0.81–2.69]). The change in odds ratio was caused by the increase in the detection ratio with flexible endoscopy as the control group. The efficacy of capsule endoscopy did not change between pre- and postmarketing settings. Heterogeneity (I2) increased in the postmarketing setting because of one study. For safety, in terms of endoscope retention in the body, data from the approval summary and adverse event reports were analyzed. The incidence of retention decreased in the postmarketing setting (premarketing: 0.75% vs postmarketing: 0.095%). The introduction of the new patency capsule for checking the patency of the digestive tract might contribute to the decrease. Conclusions Effectiveness and safety could change in the postmarketing setting. Therefore, time series meta-analyses could be

  7. 21 CFR 888.5980 - Manual cast application and removal instrument.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Manual cast application and removal instrument... and removal instrument. (a) Identification. A manual cast application and removal instrument is a...) Classification. Class I (general controls). The device is exempt from the premarket notification procedures...

  8. How pre-marketing data can be used for predicting the weight of drug interactions in clinical practice.

    PubMed

    Caccia, Silvio; Pasina, Luca; Nobili, Alessandro

    2013-04-01

    Unexpected drug interactions have led to the withdrawal of many drugs, raising concern about the gap between what is known at the time of approval and the risk of serious effects in the longer term, particularly in high-risk populations generally excluded from drug development. This is because the majority of drug interaction studies are done using in vitro methods, or in healthy young volunteers who may not reflect the complexity of patients, and the settings in which the drug will be used in clinical practice. Pre-marketing interaction studies should therefore be designed to make information easily accessible and clinically transferable. They should be adequate in terms of sample size, population, comorbidity, phenotyping and/or genotyping, end-points and outcome measures, and conducted in conditions of dose, route and timing of co-administration that reproduce the proposed therapeutic indications of the new drug. Although young volunteers have the advantage of minimizing some confounding effects introduced by diseases or polypharmacy, patients drawn from populations for whom the drug is intended would be more relevant and accurate, providing the studies are feasible and safe.

  9. 76 FR 17136 - Medical Devices; Availability of Safety and Effectiveness Summaries for Premarket Approval...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-28

    ... HUMAN SERVICES Food and Drug Administration [Docket Nos. FDA-2010-M-0519, FDA-2010-M-0556, FDA-2010-M-0558, FDA- 2010-M-0557, and FDA-2010-M-0591] Medical Devices; Availability of Safety and Effectiveness..., 2010 PMA No. Docket No. Applicant Trade name Date of action P100016 FDA-2010-M-0556.........

  10. 77 FR 37570 - Effective Date of Requirement for Premarket Approval for a Pacemaker Programmer

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-22

    ... approval application (PMA) or a notice of completion of a product development protocol (PDP) for pacemaker... a rule on small entities. There has been only one 510(k) submission assigned to this product code... for the Gross Domestic Product. FDA does not expect this final rule to result in any...

  11. 21 CFR 814.9 - Confidentiality of data and information in a premarket approval application (PMA) file.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... defined in § 20.81. (2) Any protocol for a test or study unless the protocol is shown to constitute trade..., product experience report, consumer complaint, and other similar data and information, after deletion...

  12. The Trading with the Enemy Act of 1917 and synthetic drugs: relieving scarcity, controlling prices, and establishing pre-market licensing controls.

    PubMed

    Cooper, Dale

    2005-01-01

    The "Trading with the Enemy Act" (TWEA) was enacted in October 1917 after America's entry into World War I and during a period of wartime scarcity and rising prices of synthetic drugs and dyestuffs that began in 1914. It was described as "An Act to define, regulate, and punish trading with the enemy, and for other purposes." The act and subsequent executive orders authorized an "Alien Property Custodian" to take control of all enemy property within the United States. Also, The Federal Trade Commission (FTC) was authorized to issue licenses for the use of enemy owned patents, which covered a range of industrial and consumer products. Significantly, the FTC was given the power to set the conditions for use of the patents and to fix the price for those products necessary for health. The effect of these measures was to bring federal pre-marketing control over the production, testing, and pricing of the most therapeutically significant synthetic drugs of the day. Enactment of the TWEA and the events preceding and surrounding it are significant parts of the history of the American pharmaceutical industry and federal regulation.

  13. The benefits of the 3T3 NRU test in the safety assessment of cosmetics: long-term experience from pre-marketing testing in the Czech Republic.

    PubMed

    Jírová, D; Kejlová, K; Brabec, M; Bendová, H; Kolárová, H

    2003-01-01

    We have introduced the 3T3 NRU cytotoxicity test for methodological, economical and ethical reasons as a regular part of tier pre-marketing testing to assess local tolerance of raw materials for cosmetics, household chemicals and final cosmetic products. Using the 3T3 cell line according to the standard INVITTOX protocol No.64 (NRU Assay) the borderline concentration, relevant to the highest tolerated dose, is determined for each material. The toxic effect is reached at different concentration levels specific for individual cosmetics categories, depending on their chemical characteristics. Typical ranges of cytotoxicity for specific categories of cosmetics were established after testing of hundreds of materials. The range lies between 1 microg/ml (anti-dandruff shampoos), up to 2000 microg/ml (toothpastes and mouthwashes). The 3T3 NRU cytotoxicity test is a sensitive tool able to identify more aggressive products, that are also more likely to evoke irritation in human skin. It was even possible to detect protective effects of one natural herbal ingredient. The comparative study of cytotoxicity test results and human patch test results from a group of essential oils is presented. Cytotoxicity tests represent a highly ethical approach for estimation of irritancy. On the basis of in vitro test results suggesting low risk we can proceed to confirmatory tests in human volunteers.

  14. 77 FR 33469 - Agency Information Collection Activities; Proposed Collection; Comment Request; Medical Device...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-06

    ... submissions (average annual): 38 premarket approval applications (PMA, PDP, PMR, BLA),\\1\\ 3,561 premarket... development protocol, PMR means postmarketing requirements, and BLA means biologics license applications....

  15. Mutual Recognition of the Food and Drug Administration and European Community Member State Conformity Assessment Procedures; pharmaceutical GMP inspection reports, medical device quality system evaluation reports, and certain medical device premarket evaluation reports--FDA. Proposed rule.

    PubMed

    1998-04-10

    The Food and Drug Administration (FDA) is proposing to amend its regulations pursuant to an international agreement that is expected to be concluded between the United States and the European Community (EC) (Ref. 1). Under the terms of that agreement, FDA may normally endorse good manufacturing practice (GMP) inspection reports for pharmaceuticals provided by equivalent EC Member State regulatory authorities and medical device quality system evaluation reports and certain medical device premarket evaluation reports provided by equivalent conformity assessment bodies. FDA is taking this action to enhance its ability to ensure the safety and efficacy of pharmaceuticals and medical devices through more efficient and effective utilization of its regulatory resources. The agency is requesting comments on the proposed rule.

  16. 10 CFR 903.1 - Purpose and scope; application.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., approval, and placement in effect on an interim basis by the Deputy Secretary of the Department of Energy... Marketing Administrations (PMAs) which are commenced after these regulations become effective or were...

  17. 10 CFR 903.1 - Purpose and scope; application.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., approval, and placement in effect on an interim basis by the Deputy Secretary of the Department of Energy... Marketing Administrations (PMAs) which are commenced after these regulations become effective or were...

  18. 21 CFR 814.37 - PMA amendments and resubmitted PMA's.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Premarket Approval Application (PMA) § 814... to amend a PMA or PMA supplement with any information regarding the device that is necessary for...

  19. 21 CFR 884.5380 - Contraceptive tubal occlusion device (TOD) and introducer.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (premarket approval). (c) Date premarket approval application (PMA) or notice of completion of a product development protocol (PDP) is required. A PMA or a notice of completion of a PDP is required to be filed...

  20. 21 CFR 884.5380 - Contraceptive tubal occlusion device (TOD) and introducer.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... (premarket approval). (c) Date premarket approval application (PMA) or notice of completion of a product development protocol (PDP) is required. A PMA or a notice of completion of a PDP is required to be filed...

  1. Generic approvals of irradiated foods: Application of the chemiclearance principle

    SciTech Connect

    Taub, I.A.

    1996-10-01

    The use of irradiation for food preservation requires premarket approval primarily by the Food and Drug Administration (FDA), based on data establishing the safety of the process. Several approvals have already been granted on the strength of extensive microbiological, genotoxicity, nutritional, and animal feeding studies. Extending approval to other foods that are pasteurized or are sterilized by treatment to high doses, and consequently storable of ambient temperatures, does not necessarily have to involve comprehensive research on each and every food item. Generic approvals of classes of food is possible, because of the commonality in the response of similar foods to treatment by ionizing irradiation. This commonality is the basis for the chemiclearance principle, by which it can be shown that compositionally similar conditions are toxicologically equivalent. The use of different chemical investigations into radiolytic effects in both low and high dose irradiated muscle foods will be discussed to illustrate the application of this approach for obtaining approvals, nationally and internationally.

  2. Guidance for Industry: Preparation of Premarket Submissions ...

    Center for Food Safety and Applied Nutrition (CFSAN)

    ... 用乘以消耗因数(CF)求得膳食中食品接触物质的浓度。然后用膳食浓度乘 以每人每天消耗的食品总量求得估计日摄入量。美国食品和药品管理局假设 ...

  3. 21 CFR 12.28 - Denial of hearing in whole or in part.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... application, new animal drug application, device premarket approval application or product development... established in the statutory provision governing the matter involved constitutes a waiver of the right...

  4. 21 CFR 12.28 - Denial of hearing in whole or in part.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... application, new animal drug application, device premarket approval application or product development... established in the statutory provision governing the matter involved constitutes a waiver of the right...

  5. Applications

    NASA Astrophysics Data System (ADS)

    Stern, Arthur M.

    1986-07-01

    Economic incentives have spurred numerous applications of genetically engineered organisms in manufacture of pharmaceuticals and industrial chemicals. These successes, involving a variety of methods of genetic manipulation, have dispelled early fears that genetic engineering could not be handled safely, even in the laboratory. Consequently, the potential for applications in the wider environment without physical containment is being considered for agriculture, mining, pollution control, and pest control. These proposed applications range from modest extensions of current plant breeding techniques for new disease-resistant species to radical combinations of organisms (for example, nitrogen-fixing corn plants). These applications raise concerns about potential ecological impacts (see chapter 5), largely because of adverse experiences with both deliberate and inadvertent introductions of nonindigenous species.

  6. Comparison between small radiation therapy electron beams collimated by Cerrobend and tubular applicators.

    PubMed

    Di Venanzio, Cristina; Marinelli, Marco; Tonnetti, Alessia; Verona-Rinati, Gianluca; Bagalà, Paolo; Falco, Maria Daniela; Guerra, Antonio Stefano; Pimpinella, Maria

    2015-01-08

    The purpose of this study was to compare the dosimetric properties of small field electron beams shaped by circular Cerrobend blocks and stainless steel tubular applicators. Percentage depth dose curves, beam profiles, and output factors of small-size circular fields from 2 to 5 cm diameter, obtained either by tubular applicators and Cerrobend blocks, were measured for 6, 10, and 15 MeV electron beam energies. All measurements were performed using a PTW microDiamond 60019 premarket prototype. An overall similar behavior between the two collimating systems can be observed in terms of PDD and beam profiles. However, Cerrobend collimators produce a higher bremsstrahlung background under irradiation with high-energy electrons. In such irradiation condition, larger output factors are observed for tubular applicators. Similar dosimetric properties are observed using circular Cerrobend blocks and stainless steel tubular applicators at lower beam energies. However, Cerrobend collimators allow the delivery of specific beam shapes, conformed to the target area. On the other hand, in high-energy irradiation conditions, tubular applicators produce a lower bremsstrahlung contribution, leading to lower doses outside the target volume. In addition, the higher output factors observed at high energies for tubular applicators lead to reduced treatment times.

  7. 21 CFR 814.104 - Original applications.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Humanitarian Use Devices § 814.104 Original... Development (in accordance with § 814.102) that the device qualifies as a HUD; (2) An explanation of why the device would not be available unless an HDE were granted and a statement that no comparable device...

  8. 21 CFR 814.104 - Original applications.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Humanitarian Use Devices § 814.104 Original... Development (in accordance with § 814.102) that the device qualifies as a HUD; (2) An explanation of why the device would not be available unless an HDE were granted and a statement that no comparable device...

  9. 21 CFR 814.104 - Original applications.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Humanitarian Use Devices § 814.104 Original... determination made by FDA's Office of Orphan Products Development (in accordance with § 814.102) that the device qualifies as a HUD; (2) An explanation of why the device would not be available unless an HDE were...

  10. 21 CFR 814.39 - PMA supplements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Premarket Approval Application (PMA) § 814.39 PMA supplements. Link to... or effectiveness of the device for which the applicant has an approved PMA, unless the change is of...

  11. 21 CFR 814.37 - PMA amendments and resubmitted PMA's.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Premarket Approval Application (PMA) § 814... information regarding the device that is necessary for FDA or the appropriate advisory committee to complete... applicant to amend a PMA or PMA supplement with any information regarding the device that is necessary...

  12. 21 CFR 814.39 - PMA supplements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Premarket Approval Application (PMA) § 814.39 PMA supplements. (a... before making a change affecting the safety or effectiveness of the device for which the applicant has...

  13. 21 CFR 814.39 - PMA supplements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Premarket Approval Application (PMA) § 814.39 PMA supplements. Link to... or effectiveness of the device for which the applicant has an approved PMA, unless the change is of...

  14. 21 CFR 814.37 - PMA amendments and resubmitted PMA's.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Premarket Approval Application (PMA) § 814... information regarding the device that is necessary for FDA or the appropriate advisory committee to complete... applicant to amend a PMA or PMA supplement with any information regarding the device that is necessary...

  15. 21 CFR 807.85 - Exemption from premarket notification.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... a patient named in the order of the physician or dentist (or other specially qualified person); or (2) It is intended solely for use by a physician or dentist (or other specially qualified person) and is not generally available to, or generally used by, other physicians or dentists (or other...

  16. 21 CFR 190.6 - Requirement for premarket notification.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (HFS-820), Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint... receipt of a notification made under section 413 of the Federal Food, Drug, and Cosmetic Act (the act)...

  17. 21 CFR 814.3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES General § 814.3 Definitions. Link to an amendment published at 79 FR... a medical device. (e) PMA means any premarket approval application for a class III medical...

  18. Development of an integrated modeling approach for identifying multilevel non-point-source priority management areas at the watershed scale

    NASA Astrophysics Data System (ADS)

    Chen, Lei; Zhong, Yucen; Wei, Guoyuan; Cai, Yanpeng; Shen, Zhenyao

    2014-05-01

    The identification of priority management areas (PMAs) at the large-basin scale is notably complex because of the random nature of watershed processes, which complicates the application of traditional deterministic PMAs. In this study, a multilevel PMA (ML-PMA) framework is designed as a new tool to pinpoint these sensitive areas, within a basin, that contribute the most to water quality deterioration. The main advantage of the ML-PMA framework is the wide availability of its supplementary tools and its complete framework, which integrates both watershed and river processes in addressing PMAs at the watershed scale. The watershed model, stream model, and a Markov chain approach are integrated to depict the dynamics of watershed processes and various water quality statutes. Based on the results of this study, the river migration process is vital for water quality degradation in the river network and significantly influenced the final PMA map. In addition, the proposed ML-PMA framework considers the impact of climatic conditions and hydrological properties and allows for a more cost-effective allocation of PMAs among different years. In the authors' view, the connectivity of PMAs in terms of flux distribution and propagation downstream on which the ML-PMA is based makes the ML-PMA framework particularly interesting for watershed non-point-source pollution control.

  19. Is It Really FDA Approved?

    MedlinePlus

    ... FDA approval of a premarket approval application before marketing. To receive FDA approval for these devices, manufacturers ... dialysis equipment and many types of catheters) for marketing once it has been demonstrated that the device ...

  20. 21 CFR 814.15 - Research conducted outside the United States.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... SERVICES (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES General § 814.15 Research... foreign data are applicable to the U.S. population and U.S. medical practice; (2) The studies have...

  1. 21 CFR 814.15 - Research conducted outside the United States.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... SERVICES (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES General § 814.15 Research... foreign data are applicable to the U.S. population and U.S. medical practice; (2) The studies have...

  2. 77 FR 56846 - Agency Information Collection Activities; Proposed Collection; Comment Request; Clinical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    .... FDA bases the burden on an Agency analysis of premarket submissions with clinical trials similar to... Collection; Comment Request; Clinical Laboratory Improvement Amendments of 1988 Waiver Applications AGENCY... the notice. This notice solicits comments on collections of information associated with...

  3. Creation of an iOS and Android Mobile Application for Inferior Vena Cava (IVC) Filters: A Powerful Tool to Optimize Care of Patients with IVC Filters.

    PubMed

    Deso, Steven E; Idakoji, Ibrahim A; Muelly, Michael C; Kuo, William T

    2016-06-01

    Owing to a myriad of inferior vena cava (IVC) filter types and their potential complications, rapid and correct identification may be challenging when encountered on routine imaging. The authors aimed to develop an interactive mobile application that allows recognition of all IVC filters and related complications, to optimize the care of patients with indwelling IVC filters. The FDA Premarket Notification Database was queried from 1980 to 2014 to identify all IVC filter types in the United States. An electronic search was then performed on MEDLINE and the FDA MAUDE database to identify all reported complications associated with each device. High-resolution photos were taken of each filter type and corresponding computed tomographic and fluoroscopic images were obtained from an institutional review board-approved IVC filter registry. A wireframe and storyboard were created, and software was developed using HTML5/CSS compliant code. The software was deployed using PhoneGap (Adobe, San Jose, CA), and the prototype was tested and refined. Twenty-three IVC filter types were identified for inclusion. Safety data from FDA MAUDE and 72 relevant peer-reviewed studies were acquired, and complication rates for each filter type were highlighted in the application. Digital photos, fluoroscopic images, and CT DICOM files were seamlessly incorporated. All data were succinctly organized electronically, and the software was successfully deployed into Android (Google, Mountain View, CA) and iOS (Apple, Cupertino, CA) platforms. A powerful electronic mobile application was successfully created to allow rapid identification of all IVC filter types and related complications. This application may be used to optimize the care of patients with IVC filters.

  4. Remedial Investigation Concept Plan for Picatinny Arsenal. Volume 1. Environmental Setting, Applicable Regulations, Summaries of Site Sampling Plans, Sampling Priorities, and Supporting Appendixes

    DTIC Science & Technology

    1991-03-22

    Ortho additive -- (80%) 40 gal June 1988 inventory 8aygon Propoxur (2%) 13.5 lb Sevin Carbaryl (80%) 38 lb Pyrethrins Pyrethrins (1%) 33 lb Killmaster...4 20 cans + 2.5 gal P.M.A.S. 9.5 gal Manzate 200F 7 cans + I gal Insecticides Carbaryl 4L 7 cans Proxol 80SP 1 can Oiazinon 2 gal Dursban 11 gal...1.92%) 25 cans Treflan Trifluralin (--) 70 lb Abate 4E Temephos (43%) I gal Baygon Propoxur (14.6%) 8 gal Combat ant baits Hydramethylnon (0.9%) 852

  5. 76 FR 48062 - Effective Date of Requirement for Premarket Approval for Cranial Electrotherapy Stimulator

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-08

    ...) analyzed only a subgroup of ``psychiatric subjects'' which included many types of anxiety disorders as well as non-anxiety psychiatric disorders. The subgroup represents a diagnostically heterogeneous group... under investigation was preoperative anxiety, which may not be indicative of an Axis I anxiety...

  6. 21 CFR 807.81 - When a premarket notification submission is required.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., chemical composition, energy source, or manufacturing process. (ii) A major change or modification in the... exception or alternative under § 801.128 or § 809.11 of this chapter satisfies the requirement in...

  7. 78 FR 50422 - Medical Devices; Availability of Safety and Effectiveness Summaries for Premarket Approval...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ... Calculator System. P080009, FDA-2013-M-0549..... Ethicon Endo-Surgery, SEDASYS Computer-Assisted May 3, 2013... HUMAN SERVICES Food and Drug Administration [Docket Nos. FDA-2013-M-0462, FDA-2013-M-0463, FDA-2013-M-0464, FDA- 2013-M-0549, FDA-2013-M-0592, FDA-2013-M-0594, FDA-2013-M-0595, FDA- 2013-M-0709,......

  8. 78 FR 950 - Medical Devices; Availability of Safety and Effectiveness Summaries for Premarket Approval...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-07

    ...-M-0734....... Abbott Medical Healon July 2, 2012. Optics, Inc. EndoCoat OpViscosurgical Ophthalmic... HUMAN SERVICES Food and Drug Administration [Docket Nos. FDA-2012-M-0712, FDA-2012-M-0713, FDA-2012-M-0734, FDA- 2012-M-0735, FDA-2012-M-0814, FDA-2012-M-0833, FDA-2012-M-0893, FDA- 2012-M-0965,...

  9. 78 FR 69693 - Draft Guidance for Industry: Recommendations for Premarket Notification (510(k)) Submissions for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-20

    ... Notification (510(k)) Submissions for Nucleic Acid-Based Human Leukocyte Antigen Test Kits Used for Matching of... (510(k)) Submissions for Nucleic Acid-Based Human Leukocyte Antigen (HLA) Test Kits Used for Matching...) submissions for nucleic acid-based HLA test kits used for matching of donors and recipients in transfusion...

  10. 76 FR 31965 - Medical Devices; Availability of Safety and Effectiveness Summaries for Premarket Approval...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-02

    ... December 23, 2010. SYSTEM. FDA-2011-M-0035 P100028 Cook Medical, Inc.. FORMULA BALLOON- January 14, 2011...-0132, FDA-2011-M-0170, FDA-2011-M-0175, and FDA-2011-M-0198] Medical Devices; Availability of...

  11. 78 FR 14013 - Medical Devices; Exemption From Premarket Notification; Class II Devices; Wheelchair Elevator

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-04

    ...: Electromagnetic Compatibility--Requirements and Tests,'' and ASME A18.1 ``Safety Standard for Platform Lifts and Stairway Chair Lifts'') must validate electromagnetic compatibility and electrical safety. Firms are now...: Electromagnetic Compatibility--Requirements and Tests,'' and ASME A18.1 ``Safety Standard for Platform Lifts...

  12. 78 FR 14015 - Medical Devices; Exemption From Premarket Notification; Class II Devices; Powered Patient Transport

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-04

    ... Standard: Electromagnetic Compatibility--Requirements and Tests,'' and ASME A18.1 ``Safety Standard for Platform Lifts and Stairway Chair Lifts'') must validate electromagnetic compatibility and electrical...: Electromagnetic Compatibility--Requirements and Tests,'' and ASME A18.1 ``Safety Standard for Platform Lifts...

  13. 76 FR 9583 - Draft Guidance for Industry on Clinical Pharmacogenomics: Premarketing Evaluation in Early Phase...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    ... influence the exposure- response (E/R) relationship of drugs. PGx studies can enhance the understanding of... needed to support marketing approval) can gather the additional information about effectiveness and safety that is needed to evaluate the overall benefit-risk relationship of the drug and to provide...

  14. 77 FR 2071 - Medical Devices; Availability of Safety and Effectiveness Summaries for Premarket Approval...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-13

    ... date P100031, FDA-2011-M-0502...... Roche Diagnostics ELECSYS ANTI-HBC IMMUNOASSAY & June 22, 2011. Corp.. ELECSYS PRECICONTROL ANTI-HBC. P100032, FDA-2011-M-0503...... Roche Diagnostics ELECSYS ANTI-HBC... ANALYZER. P100001, FDA-2011-M-0563...... Ortho-Clinical VITROS IMMUNODIAGNOSTICS July 20, 2011....

  15. 21 CFR 807.87 - Information required in a premarket notification submission.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... standards. (e) Proposed labels, labeling, and advertisements sufficient to describe the device, its intended... effectiveness of the device, or the device is to be marketed for a new or different indication for use, the... considered what consequences and effects the change or modification or new use might have on the safety...

  16. 21 CFR 807.90 - Format of a premarket notification submission.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Health, Document Mail Center, 10903 New Hampshire Ave., Bldg. 66, rm. G609, Silver Spring, MD 20993-0002. (2) For devices regulated by the Center for Biologics Evaluation and Research, be addressed to the Document Control Center (HFM-99), Center for Biologics Evaluation and Research, Food and...

  17. 75 FR 32476 - Agency Information Collection Activities; Proposed Collection; Comment Request; Premarket...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-08

    ... manufacture that affect the safety and effectiveness of a device subject to an approved PMA do not require submission of a PMA supplement under Sec. 814.39(a) and are eligible to be the subject of a 30-day notice. A... organization and the indexing of records into identifiable files to ensure the device's continued safety...

  18. 75 FR 72829 - Medical Devices; Availability of Safety and Effectiveness Summaries for Premarket Approval...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-26

    ... HUMAN SERVICES Food and Drug Administration Medical Devices; Availability of Safety and Effectiveness..., Center for Devices and Radiological Health, Food and Drug Administration, 10903 New Hampshire Ave., Bldg... 18, 2010. Nancy K. Stade, Deputy Director for Policy, Center for Devices and Radiological...

  19. 21 CFR 860.132 - Procedures when the Commissioner initiates a performance standard or premarket approval...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... (CONTINUED) MEDICAL DEVICES MEDICAL DEVICE CLASSIFICATION PROCEDURES Reclassification § 860.132 Procedures... the classification of a device based upon new information relevant to its classification when the Commissioner initiates a proceeding either to develop a performance standard for the device if in class II,...

  20. 75 FR 38532 - Medical Devices; Availability of Safety and Effectiveness Summaries for Premarket Approval...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-02

    ...-0063, FDA- 2010-M-0135, FDA-2010-M-0158] Medical Devices; Availability of Safety and Effectiveness..., Center for Devices and Radiological Health, Food and Drug Administration, 10903 New Hampshire Ave., Bldg... Regulations and Policy, Center for Devices and Radiological Health. BILLING CODE 4160-01-S...

  1. 75 FR 52294 - Effective Date of Requirement for Premarket Approval for Four Class III Preamendments Devices

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    ... arrhythmias or electrical shock--excessive electrical leakage current can disturb the normal electrophysiology of the heart, leading to the onset of cardiac arrhythmias. Electrical leakage can also...

  2. 78 FR 17890 - Effective Date of Requirement for Premarket Approval for Automated External Defibrillator System.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-25

    ... devices under 21 CFR 870.5300. Arrhythmia detectors and alarms are also preamendment devices that were... the preamendment class III arrhythmia detector and alarm devices in response to a 510(k) in 1985... arrhythmia detector and alarm. FDA found AEDs equivalent to the higher class of the combined devices,...

  3. 76 FR 47085 - Effective Date of Requirement for Premarket Approval for a Pacemaker Programmer

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-04

    ... recommendation. C. Risks to Health 1. Cardiac arrhythmias or electrical shock: Excessive electrical leakage current can disturb the normal electrophysiology of the heart, leading to the onset of cardiac...

  4. 76 FR 44872 - Effective Date of Requirement for Premarket Approval for an Implantable Pacemaker Pulse Generator

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    ... fainting. 3. Arrhythmias A sensing failure of the pacemaker during vulnerable periods of the cardiac cycle can induce cardiac arrhythmias, in particular, dangerously fast arrhythmias. In this case, dangerously fast arrhythmias may lead to chest pain, shortness of breath, dizziness, fainting or even death....

  5. 21 CFR 860.132 - Procedures when the Commissioner initiates a performance standard or premarket approval...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Procedures when the Commissioner initiates a... Section 860.132 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES MEDICAL DEVICE CLASSIFICATION PROCEDURES Reclassification § 860.132...

  6. 76 FR 47210 - Medical Devices; Availability of Safety and Effectiveness Summaries for Premarket Approval...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-04

    .......... Roche Molecular cobas HPV test April 19, 2011. Systems, Inc. P100029 FDA-2011-M-0296....... St. Jude...). P930014 (S45) FDA-2011-M-0338. Alcon Research, Ltd... AcrySof toric IOL and AcrySof IQ May 3, 2011....

  7. 75 FR 24708 - Agency Information Collection Activities; Proposed Collection; Comment Request; Premarket...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-05

    ... . Submit written comments on the collection of information to the Division of Dockets Management (HFA- 305... 0910-0120)--Extension Section 510(k) of the Federal Food, Drug, and Cosmetic Act (the act) (21 U.S.C. 360(k)) and the implementing regulation under part 807 (21 CFR part 807, subpart E) require a...

  8. 78 FR 5816 - Guidance for Industry on Clinical Pharmacogenomics: Premarket Evaluation in Early-Phase Clinical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-28

    ... how variations in the human genome, specifically DNA sequence variants, could affect a drug's..., specifically DNA sequence variants, could affect a drug's pharmacokinetics, pharmacodynamics, efficacy,...

  9. 76 FR 32214 - Agency Information Collection Activities; Proposed Collection; Comment Request; Premarket...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-03

    ...)--Extension Section 413(a) of the Federal Food, Drug, and Cosmetic Act (the FD&C Act) (21 U.S.C. 350b(a... ingredient, to submit to the Office of Nutrition, Labeling, and Dietary Supplements notification of the...

  10. 75 FR 47603 - Draft Guidance for Industry and Food and Drug Administration Staff; Recommendations for Premarket...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-06

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration... AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA... zonisamide assays. This draft guidance is not final nor is it in effect at this time. DATES: Although you...

  11. 77 FR 60704 - Medical Devices; Availability of Safety and Effectiveness Summaries for Premarket Approval...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-04

    ... (with the adjunctive Zenith Alignment Stent). P110029, FDA-2012-M-0372 Abbot Laboratories... ARCHITECT HBsAg April 12, 2012. Qualitative, ARCHITECT HBsAg Qualitative Confirmatory, ARCHITECT HBsAg Qualitative Confirmatory Manual Diluent, ARCHITECT HBsAg Qualitative Calibrators, and ARCHITECT...

  12. 75 FR 36099 - Medical Devices; Availability of Safety and Effectiveness Summaries for Premarket Approval...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-24

    ... Dockets Management. ADDRESSES: Submit written requests for copies of summaries of safety and effectiveness data to the Division of Dockets Management (HFA-305), Food and Drug Administration, 5630 Fishers Lane... document when submitting a written request. See the SUPPLEMENTARY INFORMATION section for electronic...

  13. 77 FR 35690 - Medical Devices; Availability of Safety and Effectiveness Summaries for Premarket Approval...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-14

    ........ Boston Scientific TAXUS Express2 February 22, 2012. Corp. Paclitaxel-Eluting Coronary Stent System... the Agency's Division of Dockets Management. ADDRESSES: Submit written requests for copies of summaries of safety and effectiveness data to the Division of Dockets Management (HFA-305), Food and...

  14. 75 FR 54154 - Medical Devices; Availability of Safety and Effectiveness Summaries for Premarket Approval...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-03

    ... BRONCHIAL THERMOPLASTY April 27, 2010 FDA-2010-0242 P090007 Roche Diagnostics ELECSYS ANTI-HCV IMMUNOASSAY AND April 29, 2010 FDA-2010-M-0261 Corp. ELECSYS PRECICONTROL ANTI-HCV FOR USE ON THE COBAS E411 IMMUNOASSAY ANALYZER P090008 Roche Diagnostics ELECSYS ANTI-HCV IMMUNOASSAY AND April 29, 2010...

  15. 77 FR 37573 - Effective Date of Requirement for Premarket Approval for an Implantable Pacemaker Pulse Generator

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-22

    ... Approval for an Implantable Pacemaker Pulse Generator AGENCY: Food and Drug Administration, HHS. ACTION... protocol (PDP) for implantable pacemaker pulse generators. The Agency has summarized its findings regarding... PMA or notice of completion of a PDP for the implantable pacemaker pulse generator. In accordance...

  16. 21 CFR 807.90 - Format of a premarket notification submission.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... SERVICES (CONTINUED) MEDICAL DEVICES ESTABLISHMENT REGISTRATION AND DEVICE LISTING FOR MANUFACTURERS AND.... (2) For devices regulated by the Center for Biologics Evaluation and Research, be addressed to the Document Control Center (HFM-99), Center for Biologics Evaluation and Research, Food and...

  17. 78 FR 4094 - Effective Date of Requirement for Premarket Approval for Two Class III Preamendments Devices

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-18

    ... the following two class III preamendments devices: Hip joint metal/metal semi- constrained, with a cemented acetabular component, prosthesis; and hip joint metal/metal semi-constrained, with an uncemented.... Hip Joint Metal/Metal Semi-Constrained, With a Cemented Acetabular Component, Prosthesis (21 CFR...

  18. 78 FR 17415 - Medical Devices; Availability of Safety and Effectiveness Summaries for Premarket Approval...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-21

    ... Assist System. P120008, FDA-2012-M-1176 Abbott Laboratories.. ARCHITECT AFP Assay, November 28, 2012. ARCHITECT AFP Calibrators and ARCHITECT AFP Controls. II. Electronic Access Persons with access to...

  19. 78 FR 44130 - Agency Information Collection Activities; Proposed Collection; Comment Request; Premarket...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... (OMB Control Number 0910-0120)--Extension Section 510(k) of the Federal Food, Drug, and Cosmetic Act... form. The most likely respondents to this information collection will be specification developers...

  20. PMGA and its application in area and power optimization for ternary FPRM circuit

    NASA Astrophysics Data System (ADS)

    Pengjun, Wang; Kangping, Li; Huihong, Zhang

    2016-01-01

    Based on the research of population migration algorithms (PMAs), a population migration genetic algorithm (PMGA) is proposed, combining a PMA with a genetic algorithm. A scheme of area and power optimization for a ternary FPRM circuit is proposed by using the PMGA. Firstly, according to the ternary FPRM logic function expression, area and power estimation models are established. Secondly, the PMGA is used to search for the best area and power polarity. Finally, 10 MCNC Benchmark circuits are used to verify the effectiveness of the proposed method. The results show that the ternary FPRM circuits optimized by the PMGA saved 13.33% area and 20.00% power on average than the corresponding FPRM circuits optimized by a whole annealing genetic algorithm. Project supported by the Natural Science Foundation of Zhejiang Province (No. LY13F040003), the National Natural Science Foundation of China (Nos. 61234002, 61306041), and the K. C. Wong Magna Fund in Ningbo University.

  1. Haptic control of a pneumatic muscle actuator to provide resistance for simulated isokinetic exercise; part II: control development and testing.

    PubMed

    Hall, Kara L; Phillips, Chandler A; Reynolds, David B; Mohler, Stanley R; Rogers, Dana B; Neidhard-Doll, Amy T

    2015-01-01

    Pneumatic muscle actuators (PMAs) have a high power to weight ratio and possess unique characteristics which make them ideal actuators for applications involving human interaction. PMAs are difficult to control due to nonlinear dynamics, presenting challenges in system implementation. Despite these challenges, PMAs have great potential as a source of resistance for strength training and rehabilitation. The objective of this work was to control a PMA for use in isokinetic exercise, potentially benefiting anyone in need of optimal strength training through a joint's range of motion. The controller, based on an inverse three-element phenomenological model and adaptive nonlinear control, allows the system to operate as a type of haptic device. A human quadriceps dynamic simulator was developed (as described in Part I of this work) so that control effectiveness and accommodation could be tested prior to human implementation. Tracking error results indicate that the control system is effective at producing PMA displacement and resistance necessary for a scaled, simulated neuromuscular actuator to maintain low-velocity isokinetic movement during simulated concentric and eccentric knee extension.

  2. 21 CFR 814.42 - Filing a PMA.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... PREMARKET APPROVAL OF MEDICAL DEVICES FDA Action on a PMA § 814.42 Filing a PMA. (a) The filing of an application means that FDA has made a threshold determination that the application is sufficiently complete to permit a substantive review. Within 45 days after a PMA is received by FDA, the agency will notify...

  3. Biomedical Applications

    NASA Astrophysics Data System (ADS)

    Méndez, Vicenç; Fedotov, Sergei; Horsthemke, Werner

    Reaction-transport equations have found many applications to biological processes of interest in medicine and microbiology. Examples range from cancer invasion to virus dispersal and transport in spiny dendrites.

  4. Rejected applications

    PubMed Central

    2014-01-01

    Objective: To review membership application materials (especially rejected applications) to the American Academy of Neurology (AAN) during its formative years (1947–1953). Methods: Detailed study of materials in the AAN Historical Collection. Results: The author identified 73 rejected applications. Rejected applicants (71 male, 2 female) lived in 25 states. The largest number was for the Associate membership category (49). These were individuals “in related fields who have made and are making contributions to the field of neurology.” By contrast, few applicants to Active membership or Fellowship status were rejected. The largest numbers of rejectees were neuropsychiatrists (19), neurosurgeons (16), and psychiatrists (14). Conclusion: The AAN, established in the late 1940s, was a small and politically vulnerable organization. A defining feature of the fledgling society was its inclusiveness; its membership was less restrictive than that of the older American Neurological Association. At the same time, the society needed to preserve its core as a neurologic society rather than one of psychiatry or neurosurgery. Hence, the balance between inclusiveness and exclusive identity was a difficult one to maintain. The Associate membership category, more than any other, was at the heart of this issue of self-definition. Associate members were largely practitioners of psychiatry or neurosurgery. Their membership was a source of consternation and was to be carefully been held in check during these critical formative years. PMID:24944256

  5. ASCI applications

    SciTech Connect

    Nowak, D.A.; Christensen, R.C.

    1997-11-11

    ASCI applications codes are key elements of the Department of Energy`s Stockpile Stewardship and Management Program (SSMP). They will provide the simulation capabilities needed to predict the performance, safety, reliability, and manufacturability of the U.S. nuclear deterrent.

  6. 78 FR 101 - Guidance for Industry and Food and Drug Administration Staff; Acceptance and Filing Reviews for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-02

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry and Food and Drug Administration Staff; Acceptance and Filing Reviews for Premarket Approval Applications; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing...

  7. 5 CFR 2641.201 - Permanent restriction on any former employee's representations to United States concerning...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... Legislation or rulemaking of general applicability and the formulation of general policies, standards or... policies for a grant program for organizations nationwide to produce science education programs targeting... manufacturers of a particular type of medical device to obtain pre-market approval for their products. It...

  8. 75 FR 41986 - Medical Devices; Pediatric Uses of Devices; Requirements for Submission of Information on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-20

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 814 RIN 0910-AG29 Medical Devices; Pediatric Uses of Devices; Requirements for Submission of Information on Pediatric Subpopulations That Suffer... available pediatric medical device information as a part of premarket approval applications, requests...

  9. 78 FR 8543 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ... premarket notifications, 12 panel track supplements, 180 real-time supplements, 127 180-day supplements, 749... necessary to either initiate or defer the application review. FDA estimates the burden of this collection of information as follows: Table 1--Estimated Annual Reporting Burden No. of Average Form FDA No. No....

  10. 21 CFR 814.84 - Reports.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Postapproval Requirements § 814.84 Reports. (a) The holder of an approved PMA shall comply with the requirements of part 803 and with any other requirements applicable to the...

  11. 21 CFR 814.126 - Postapproval requirements and reports.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Humanitarian Use Devices § 814.126... of § 814.82(a)(7). In addition, medical device reports submitted to FDA in compliance with the... known or reasonably should be known to the applicant, medical device reports made under part 803 of...

  12. 21 CFR 814.126 - Postapproval requirements and reports.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Humanitarian Use Devices § 814.126... of § 814.82(a)(7). In addition, medical device reports submitted to FDA in compliance with the... known or reasonably should be known to the applicant, medical device reports made under part 803 of...

  13. 21 CFR 814.84 - Reports.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Postapproval Requirements § 814.84 Reports. (a) The holder of an approved PMA shall comply with the requirements of part 803 and with any other requirements applicable to the...

  14. 21 CFR 814.84 - Reports.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES Postapproval Requirements § 814.84 Reports. (a) The holder of an approved PMA shall comply with the requirements of part 803 and with any other requirements applicable to the...

  15. 75 FR 4407 - The Neurological Devices Panel of the Medical Devices Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-27

    ... check the agency's Web site and call the appropriate advisory committee hot line/phone line to learn... discuss, make recommendations, and vote on a premarket approval application for the Deep Brain Stimulation... before the meeting. If FDA is unable to post the background material on its Web site prior to the...

  16. 75 FR 16365 - Medical Devices; Pediatric Uses of Devices; Requirement for Submission of Information on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 814 RIN 0910-AG29 Medical Devices; Pediatric... the regulations on premarket approval of medical devices to include requirements relating to the... submit certain medical device applications to include readily available information providing...

  17. 77 FR 16038 - Circulatory System Devices Panel of the Medical Devices Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-19

    ... HUMAN SERVICES Food and Drug Administration Circulatory System Devices Panel of the Medical Devices... (FDA). The meeting will be open to the public. Name of Committee: Circulatory System Devices Panel of... the premarket approval application (PMA) for the HeartWare Ventricular Assist System (HVAS)...

  18. 76 FR 43693 - Standard Operating Procedure for “Notice to Industry” Letters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-21

    ... (CDRH) process to clarify and more quickly inform stakeholders when CDRH has changed its expectations... has changed its expectations for data submitted as part of an IDE or premarket application on the... about changes in regulatory expectations or new scientific information is important. The Task...

  19. 21 CFR 3.9 - Effect of letter of designation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Effect of letter of designation. 3.9 Section 3.9 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PRODUCT JURISDICTION Assignment of Agency Component for Review of Premarket Applications § 3.9 Effect of letter...

  20. 21 CFR 3.9 - Effect of letter of designation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Effect of letter of designation. 3.9 Section 3.9 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PRODUCT JURISDICTION Assignment of Agency Component for Review of Premarket Applications § 3.9 Effect of letter...

  1. 21 CFR 812.38 - Confidentiality of data and information.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... date of a notice of completion of a product development protocol except as provided in this section... application for premarket approval of the device subject to the IDE; or a notice of completion of a product development protocol for the device has become effective. (b) Availability of summaries or data. (1) FDA...

  2. 21 CFR 812.38 - Confidentiality of data and information.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... date of a notice of completion of a product development protocol except as provided in this section... application for premarket approval of the device subject to the IDE; or a notice of completion of a product development protocol for the device has become effective. (b) Availability of summaries or data. (1) FDA...

  3. 21 CFR 60.22 - Regulatory review period determinations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... application for premarket approval of the device or a notice of completion of a product development protocol... notice of completion of a product development protocol is initially submitted under section 515 of the... completion of a product development protocol, or a petition is initially submitted on the date it...

  4. 77 FR 70168 - Guidance for Industry and Food and Drug Administration Staff; The Content of Investigational...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-23

    .... On June 22, 2011 (76 FR 36542), FDA announced the availability of the draft guidance document...) Device Systems.'' On December 6, 2011 (76 FR 76166), FDA announced the availability of the draft guidance...; The Content of Investigational Device Exemption and Premarket Approval Applications for...

  5. 21 CFR 814.15 - Research conducted outside the United States.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... SERVICES (CONTINUED) MEDICAL DEVICES PREMARKET APPROVAL OF MEDICAL DEVICES General § 814.15 Research... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Research conducted outside the United States. 814... paragraph (b) or (c) of this section, as applicable. (b) Research begun on or after effective date. FDA...

  6. Application note :

    SciTech Connect

    Russo, Thomas V.

    2013-08-01

    The development of the XyceTM Parallel Electronic Simulator has focused entirely on the creation of a fast, scalable simulation tool, and has not included any schematic capture or data visualization tools. This application note will describe how to use the open source schematic capture tool gschem and its associated netlist creation tool gnetlist to create basic circuit designs for Xyce, and how to access advanced features of Xyce that are not directly supported by either gschem or gnetlist.

  7. Photography applications

    USGS Publications Warehouse

    Cochran, Susan A.; Goodman, James A.; Purkis, Samuel J.; Phinn, Stuart R.

    2013-01-01

    Photographic imaging is the oldest form of remote sensing used in coral reef studies. This chapter briefly explores the history of photography from the 1850s to the present, and delves into its application for coral reef research. The investigation focuses on both photographs collected from low-altitude fixed-wing and rotary aircraft, and those collected from space by astronauts. Different types of classification and analysis techniques are discussed, and several case studies are presented as examples of the broad use of photographs as a tool in coral reef research.

  8. Premarket Evaluations of the IMDx C. difficile for Abbott m2000 Assay and the BD Max Cdiff Assay

    PubMed Central

    Espino, A. A.; Maceira, V. P.; Nattanmai, S. M.; Butt, S. A.; Wroblewski, D.; Hannett, G. E.; Musser, K. A.

    2014-01-01

    Clostridium difficile-associated diarrhea is a well-recognized complication of antibiotic use. Historically, diagnosing C. difficile has been difficult, as antigen assays are insensitive and culture-based methods require several days to yield results. Nucleic acid amplification tests (NAATs) are quickly becoming the standard of care. We compared the performance of two automated investigational/research use only (IUO/RUO) NAATs for the detection of C. difficile toxin genes, the IMDx C. difficile for Abbott m2000 Assay (IMDx) and the BD Max Cdiff Assay (Max). A prospective analysis of 111 stool specimens received in the laboratory for C. difficile testing by the laboratory's test of record (TOR), the BD GeneOhm Cdiff Assay, and a retrospective analysis of 88 specimens previously determined to be positive for C. difficile were included in the study. One prospective specimen was excluded due to loss to follow-up discrepancy analysis. Of the remaining 198 specimens, 90 were positive by all three methods, 9 were positive by TOR and Max, and 3 were positive by TOR only. One negative specimen was initially inhibitory by Max. The remaining 95 specimens were negative by all methods. Toxigenic C. difficile culture was performed on the 12 discrepant samples. True C. difficile-positive status was defined as either positive by all three amplification assays or positive by toxigenic culture. Based on this definition, the sensitivity and specificity were 96.9% and 95% for Max and 92.8% and 100% for IMDx. In summary, both highly automated systems demonstrated excellent performance, and each has individual benefits, which will ensure that they will both have a niche in clinical laboratories. PMID:24554744

  9. Premarket evaluations of the IMDx C. difficile for Abbott m2000 Assay and the BD Max Cdiff Assay.

    PubMed

    Stellrecht, K A; Espino, A A; Maceira, V P; Nattanmai, S M; Butt, S A; Wroblewski, D; Hannett, G E; Musser, K A

    2014-05-01

    Clostridium difficile-associated diarrhea is a well-recognized complication of antibiotic use. Historically, diagnosing C. difficile has been difficult, as antigen assays are insensitive and culture-based methods require several days to yield results. Nucleic acid amplification tests (NAATs) are quickly becoming the standard of care. We compared the performance of two automated investigational/research use only (IUO/RUO) NAATs for the detection of C. difficile toxin genes, the IMDx C. difficile for Abbott m2000 Assay (IMDx) and the BD Max Cdiff Assay (Max). A prospective analysis of 111 stool specimens received in the laboratory for C. difficile testing by the laboratory's test of record (TOR), the BD GeneOhm Cdiff Assay, and a retrospective analysis of 88 specimens previously determined to be positive for C. difficile were included in the study. One prospective specimen was excluded due to loss to follow-up discrepancy analysis. Of the remaining 198 specimens, 90 were positive by all three methods, 9 were positive by TOR and Max, and 3 were positive by TOR only. One negative specimen was initially inhibitory by Max. The remaining 95 specimens were negative by all methods. Toxigenic C. difficile culture was performed on the 12 discrepant samples. True C. difficile-positive status was defined as either positive by all three amplification assays or positive by toxigenic culture. Based on this definition, the sensitivity and specificity were 96.9% and 95% for Max and 92.8% and 100% for IMDx. In summary, both highly automated systems demonstrated excellent performance, and each has individual benefits, which will ensure that they will both have a niche in clinical laboratories.

  10. 76 FR 20688 - Guidance for Industry and Food and Drug Administration Staff; 30-Day Notices, 135-Day Premarket...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry and Food and Drug Administration Staff... Supplements for Manufacturing Method or Process Changes; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability...

  11. 77 FR 39953 - Effective Date of Requirement for Premarket Approval for Shortwave Diathermy for All Other Uses

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-06

    ... system for the regulation of medical devices intended for human use. Section 513 of the FD&C Act (21 U.S... cause excessive heating that results in tissue damage. In addition, a September 2011 review of Medical... shown that SWD can cause heating of implanted wire leads and presents the risk of thermal injury...

  12. Assessing new developments in the pre-market regulatory process of medical devices in the People's Republic of China.

    PubMed

    Zhang, Shixuan; Kriza, Christine; Kolominsky-Rabas, Peter L

    2014-09-01

    The objective of this paper is to provide a systematic overview of the Chinese medical device registration processes, identify challenges and suggest how these can be addressed. In addition, the paper will outline the impact of new policies and regulations since the restructuring of the China FDA. A systematic review was performed for journal articles between the year of 2009 and 2013 in the following databases: PubMed, ScienceDirect and Zhongguozhiwang. The review has identified 184 papers which were potentially relevant. Seventeen articles were included in the review, which highlights the challenges and opportunities related to the medical device registration process. In order to understand the actual impact of the regulation environment and its policies including the lack of regulatory guidance regular assessment updates are crucial. The results of this paper are aimed at informing regulatory bodies, health policy decision makers, national and international Health Technology Assessment networks as well as medical devices manufacturers.

  13. Medical Applications

    NASA Astrophysics Data System (ADS)

    Boccara, A. Claude; Mordon, Serge

    2015-10-01

    In re-listening to the lectures of Charles Townes shortly after the invention of the laser (e.g., in the Boston Science Museum), one can already have a realistic vision of the potentialities of this new tool in the field of medical therapy, as evidenced by the use of the laser in ophthalmology to cure retinal detachment in the 1960's. Since then, applications have flourished in the domain of therapy. We will thus illustrate here only some of the main fields of application of medical lasers. On the opposite, the use of lasers in medical imaging is, with one exception in ophthalmology, still at the development level. It is becoming a diagnostic tool in addition to high performance imaging facilities that are often very expensive (such as CT scan, Magnetic Resonance Imaging (MRI) and nuclear imaging). Even if progress is sometimes slow, one can now image with light inside the human body, in spite of the strong scattering of light by tissues, in the same way as a pathologist sees surgical specimens.

  14. 76 FR 81510 - Draft Guidance for Industry and Food and Drug Administration Staff; the 510(k) Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-28

    ... Staff; the 510(k) Program: Evaluating Substantial Equivalence in Premarket Notifications ; Availability... and Drug Administration Staff; The 510(k) Program: Evaluating Substantial Equivalence in Premarket... reviews premarket notification (510(k)) submissions as well as on the Special and Abbreviated...

  15. 77 FR 39498 - Guidances for Industry and Food and Drug Administration Staff: Computer-Assisted Detection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ...--Premarket Notification (510(k)) Submissions; and Clinical Performance Assessment: Considerations for... Approval and Premarket Notification (510(k)) Submissions; Availability AGENCY: Food and Drug Administration... Applied to Radiology Images and Radiology Device Data--Premarket Notification (510(k)) Submissions''...

  16. Immobilisation of fully sulfonated polyaniline on nanostructured calcium silicate.

    PubMed

    Borrmann, Thomas; Dominis, Anton; McFarlane, Andrew J; Johnston, James H; Richardson, Michael J; Kane-Maguire, Leon A P; Wallace, Gordon G

    2007-12-01

    Up to 7.4% (w/w) of the sulfonated polyaniline, poly(2-methoxyaniline-5-sulfonic acid) (PMAS) can be absorbed onto nanostructured calcium silicates. Spectroscopic and leaching studies on the novel PMAS-silicate nanocomposites obtained indicate that attachment of the PMAS occurs via electrostatic binding of PMAS sulfonate groups to Ca2+ sites on the silicates. The surface area and pore volume of the nanocomposites are comparable to those of pure silicate and increase the surface area of the PMAS polymer by several orders of magnitude. The PMAS emeraldine salt in the nanocomposites retains its chemical reactivity, being readily oxidised and reduced to its pernigraniline and leucoemeraldine forms, respectively. The conductivity of the composite is comparable to that of the pure PMAS, several orders of magnitude higher than that of dried nanostructured calcium silicate.

  17. BPPD Internal Application Checklists

    EPA Pesticide Factsheets

    EPA, Office of Pesticide Programs, BPPD internal application checklists for internal guidance to assist BPPD employees in their evaluation of applications submitted to BPPD by applicants and/or registrants.

  18. Aerospace Applications of Microprocessors

    NASA Technical Reports Server (NTRS)

    1980-01-01

    An assessment of the state of microprocessor applications is presented. Current and future requirements and associated technological advances which allow effective exploitation in aerospace applications are discussed.

  19. Sight Application Analysis Tool

    SciTech Connect

    Bronevetsky, G.

    2014-09-17

    The scale and complexity of scientific applications makes it very difficult to optimize, debug and extend them to support new capabilities. We have developed a tool that supports developers’ efforts to understand the logical flow of their applications and interactions between application components and hardware in a way that scales with application complexity and parallelism.

  20. Ruby on Rails Applications

    NASA Technical Reports Server (NTRS)

    Hochstadt, Jake

    2011-01-01

    Ruby on Rails is an open source web application framework for the Ruby programming language. The first application I built was a web application to manage and authenticate other applications. One of the main requirements for this application was a single sign-on service. This allowed authentication to be built in one location and be implemented in many different applications. For example, users would be able to login using their existing credentials, and be able to access other NASA applications without authenticating again. The second application I worked on was an internal qualification plan app. Previously, the viewing of employee qualifications was managed through Excel spread sheets. I built a database driven application to streamline the process of managing qualifications. Employees would be able to login securely to view, edit and update their personal qualifications.

  1. CYBER 200 Applications Seminar

    NASA Technical Reports Server (NTRS)

    Gary, J. P. (Compiler)

    1984-01-01

    Applications suited for the CYBER 200 digital computer are discussed. Various areas of application including meteorology, algorithms, fluid dynamics, monte carlo methods, petroleum, electronic circuit simulation, biochemistry, lattice gauge theory, economics and ray tracing are discussed.

  2. RHC Technologies and Applications

    EPA Pesticide Factsheets

    This page provides a portal to learning about several of the most common types of renewable heating and cooling technologies and end use applications. A clickable diagram compares technologies and applications with respect to their working temperatures.

  3. EPA Geospatial Applications

    EPA Pesticide Factsheets

    EPA has developed many applications that allow users to explore and interact with geospatial data. This page highlights some of the flagship geospatial web applications but these represent only a fraction of the total.

  4. Entomopathogenic nematode application technology

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Biocontrol success when using entomopathogenic nematodes (EPNs) in the genera Heterorhabditis and Steinernema relies on a variety of factors including components of the application event itself. Successful application encompasses both abiotic and biotic influences. For example, adverse array of equi...

  5. Industrial storage applications overview

    NASA Technical Reports Server (NTRS)

    Duscha, R. A.

    1980-01-01

    The implementation of a technology demonstration for the food processing industry, development and technology demonstrations for selected near-term, in-plant applications and advanced industrial applications of thermal energy storage are overviewed.

  6. Parts application handbook study

    NASA Technical Reports Server (NTRS)

    1978-01-01

    The requirements for a NASA application handbook for standard electronic parts are determined and defined. This study concentrated on identifying in detail the type of information that designers and parts engineers need and expect in a parts application handbook for the effective application of standard parts on NASA projects.

  7. Inertial MEMS System Applications

    DTIC Science & Technology

    2010-03-01

    Inertial MEMS System Applications N. Barbour, R. Hopkins, A. Kourepenis, P. Ward The Charles Stark Draper Laboratory (P-4993) 555 Technology...driven by gun-launched projectile requirements. The application of silicon MEMS inertial technology to competent munitions efforts began in the early...requirements. These applications have a unique combination of requirements including, performance over temperature, high-g launch survivability, fast

  8. Application Portable Parallel Library

    NASA Technical Reports Server (NTRS)

    Cole, Gary L.; Blech, Richard A.; Quealy, Angela; Townsend, Scott

    1995-01-01

    Application Portable Parallel Library (APPL) computer program is subroutine-based message-passing software library intended to provide consistent interface to variety of multiprocessor computers on market today. Minimizes effort needed to move application program from one computer to another. User develops application program once and then easily moves application program from parallel computer on which created to another parallel computer. ("Parallel computer" also include heterogeneous collection of networked computers). Written in C language with one FORTRAN 77 subroutine for UNIX-based computers and callable from application programs written in C language or FORTRAN 77.

  9. Engineering electrochemical capacitor applications

    NASA Astrophysics Data System (ADS)

    Miller, John R.

    2016-09-01

    Electrochemical capacitor (EC) applications have broadened tremendously since EC energy storage devices were introduced in 1978. Then typical applications operated below 10 V at power levels below 1 W. Today many EC applications operate at voltages approaching 1000 V at power levels above 100 kW. This paper briefly reviews EC energy storage technology, shows representative applications using EC storage, and describes engineering approaches to design EC storage systems. Comparisons are made among storage systems designed to meet the same application power requirement but using different commercial electrochemical capacitor products.

  10. SNS application programming plan.

    SciTech Connect

    Chu, C. M.; Galambos, J. D.; Wei, J.; Allen, C.; McGehee, P. M.; Malitsky, N.

    2001-01-01

    The plan for Spallation Neutron Source accelerator physics application programs is presented. These high level applications involve processing and managing information from the diagnostic instruments, the machine control system, models and static databases and will be used to investigate and control beam behavior. Primary components include an SNS global database and Java-based XAL Application Toolkit. A key element in the SNS application programs is time synchronization of data used in these applications, due to the short pulse (1 ms), pulsed (60 Hz) nature of the device. The data synchronization progress is also presented.

  11. Biopharmaceutical applications of nanogold

    PubMed Central

    Alanazi, Fars K.; Radwan, Awwad A.; Alsarra, Ibrahim A.

    2010-01-01

    The application of nanogold in biopharmaceutical field is reviewed in this work. The properties of nanogold including nanogold surface Plasmon absorption and nanogold surface Plasmon light scattering are illustrated. The physical, chemical, biosynthesis methods of nanogold preparation are presented. Catalytic properties as well as biomedical applications are highlighted as one of the most important applications of nanogold. Biosensing, and diagnostic and therapeutic applications of gold nanoparticles are evaluated. Moreover, gold nanoparticles in drugs, biomolecules and proteins’ delivery are analyzed. Gold nanoparticles for the site-directed photothermal applications are reviewed as the most fruitful research area in the future. PMID:24936133

  12. ERIP application instructions

    SciTech Connect

    Watt, D.M.

    1992-01-02

    This report provides background information and instructions to assist applicants in writing Energy-Related Inventions Program (ERIP) applications. Initial feedback fro usage for the new instructions shows that the best instructions would not be read and followed by all applicants. Applications from more than thirty applicants who have received the new instructions indicated that few had read the instructions. Based on this feedback, the instructions have been further revised to include a title page and table of contents. A warning was also added to advise applicants of the potential penalty of delayed review if these instructions are not followed. This revision was intended to address the possibility that some applicants did not see or bother to follow the instructions which followed the background information about ERIP. Included are two examples of ERIP applications which have been prepared for handout at workshops or mailing to applicants. Writing of example applications was time consuming and more difficult than expected for several reasons: (1) Full disclosures can be lengthy, very detailed, and technical. This contrasts with the desire to prepare examples which are comparatively short and easy for the non-technical person to read. (2) Disclosures contain confidential information which should not be published. (3) It is difficult to imagine that applicants will study examples when they do not bother to read the basic instructions.

  13. Tissue Engineered Constructs: Perspectives on Clinical Translation

    PubMed Central

    Lu, Lichun; Arbit, Harvey M.; Herrick, James L.; Segovis, Suzanne Glass; Maran, Avudaiappan; Yaszemski, Michael J.

    2015-01-01

    In this article, a “bedside to bench and back” approach for developing tissue engineered medical products (TEMPs) for clinical applications is reviewed. The driving force behind this approach is unmet clinical needs. Preclinical research, both in vitro and in vivo using small and large animal models, will help find solutions to key research questions. In clinical research, ethical issues regarding the use of cells and tissues, their sources, donor consent, as well as clinical trials are important considerations. Regulatory issues, at both institutional and government levels, must be addressed prior to the translation of TEMPs to clinical practice. TEMPs are regulated as drugs, biologics, devices, or combination products by the US Food and Drug Administration (FDA). Depending on the mode of regulation, applications for TEMP introduction must be filed with the FDA to demonstrate safety and effectiveness in premarket clinical studies, followed by 510(k) premarket clearance or premarket approval (for medical devices), biologics license application approval (for biologics), or New Drug Application approval (for drugs). A case study on nerve cuffs is presented to illustrate the regulatory process. Finally, perspectives on commercialization such as finding a company partner and funding issues, as well as physician culture change, are presented. PMID:25711151

  14. Technical applications of aerogels

    SciTech Connect

    Hrubesh, L.W.

    1997-08-18

    Aerogel materials posses such a wide variety of exceptional properties that a striking number of applications have developed for them. Many of the commercial applications of aerogels such as catalysts, thermal insulation, windows, and particle detectors are still under development and new application as have been publicized since the ISA4 Conference in 1994: e.g.; supercapacitors, insulation for heat storage in automobiles, electrodes for capacitive deionization, etc. More applications are evolving as the scientific and engineering community becomes familiar with the unusual and exceptional physical properties of aerogels, there are also scientific and technical application, as well. This paper discusses a variety of applications under development at Lawrence Livermore National Laboratory for which several types of aerogels are formed in custom sizes and shapes. Particular discussions will focus on the uses of aerogels for physics experiments which rely on the exceptional, sometimes unique, properties of aerogels.

  15. Food and Drug Administration Efforts to Mitigate Contact Lens Discomfort.

    PubMed

    Hampton, Denise; Green, Joffre Angelo; Robboy, Marc; Eydelman, Malvina

    2017-01-01

    The premarket review of contact lenses and accessories by the FDA involves the assessment of nonclinical and clinical information in support of clearance or approval of marketing applications. The review process for these medical devices, including attributes, which may contribute to comfort for lens wearers, is summarized, as are mechanisms by which FDA continues to assess and improve recommendations through the review process and through collaboration with external entities.

  16. Irregular Applications: Architectures & Algorithms

    SciTech Connect

    Feo, John T.; Villa, Oreste; Tumeo, Antonino; Secchi, Simone

    2012-02-06

    Irregular applications are characterized by irregular data structures, control and communication patterns. Novel irregular high performance applications which deal with large data sets and require have recently appeared. Unfortunately, current high performance systems and software infrastructures executes irregular algorithms poorly. Only coordinated efforts by end user, area specialists and computer scientists that consider both the architecture and the software stack may be able to provide solutions to the challenges of modern irregular applications.

  17. Exploiting chaos for applications

    SciTech Connect

    Ditto, William L.; Sinha, Sudeshna

    2015-09-15

    We discuss how understanding the nature of chaotic dynamics allows us to control these systems. A controlled chaotic system can then serve as a versatile pattern generator that can be used for a range of application. Specifically, we will discuss the application of controlled chaos to the design of novel computational paradigms. Thus, we present an illustrative research arc, starting with ideas of control, based on the general understanding of chaos, moving over to applications that influence the course of building better devices.

  18. Application Layer Multicast

    NASA Astrophysics Data System (ADS)

    Allani, Mouna; Garbinato, Benoît; Pedone, Fernando

    An increasing number of Peer-to-Peer (P2P) Internet applications rely today on data dissemination as their cornerstone, e.g., audio or video streaming, multi-party games. These applications typically depend on some support for multicast communication, where peers interested in a given data stream can join a corresponding multicast group. As a consequence, the efficiency, scalability, and reliability guarantees of these applications are tightly coupled with that of the underlying multicast mechanism.

  19. LANL application communication patterns

    SciTech Connect

    Pakiin, Scott

    2011-01-10

    This brief presentation describes the communication patterns used by a set of unclassified applications developed at Los Alamos National Laboratory: XNobel/XRAGE/RAGE/SAGE, Krak, Sweep3D, and Partisn. It mentions which processes communicate with which other processes, whether the application is typically run in a strong-scaling mode or a weak-scaling mode, what message sizes are commonly used, and how the application's performance changes at scale.

  20. Application Power Signature Analysis

    SciTech Connect

    Hsu, Chung-Hsing; Combs, Jacob; Nazor, Jolie; Santiago, Fabian; Thysell, Rachelle; Rivoire, Suzanne; Poole, Stephen W

    2014-01-01

    The high-performance computing (HPC) community has been greatly concerned about energy efficiency. To address this concern, it is essential to understand and characterize the electrical loads of HPC applications. In this work, we study whether HPC applications can be distinguished by their power-consumption patterns using quantitative measures in an automatic manner. Using a collection of 88 power traces from 4 different systems, we find that basic statistical measures do a surprisingly good job of summarizing applications' distinctive power behavior. Moreover, this study opens up a new area of research in power-aware HPC that has a multitude of potential applications.

  1. International Space Station Environmental Control and Life Support System: Verification for the Pressurized Mating Adapters

    NASA Technical Reports Server (NTRS)

    Williams, David E.

    2007-01-01

    The International Space Station (ISS) Pressurized Mating Adapters (PMAs) Environmental Control and Life Support (ECLS) System is comprised of three subsystems: Atmosphere Control and Supply (ACS), Temperature and Humidity Control (THC), and Water Recovery and Management (WRM). PMA 1 and PMA 2 flew to ISS on Flight 2A and PMA 3 flew to ISS on Flight 3A. This paper provides a summary of the PMAs ECLS design and the detailed Element Verification methodologies utilized during the Qualification phase for the PMAs.

  2. 76 FR 60836 - Applicants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION... applicants have filed with the Federal Maritime Commission an application for a license as a Non-Vessel... Intermediaries, Federal Maritime Commission, Washington, DC 20573, by telephone at (202) 523-5843 or by e-mail...

  3. Application Security Automation

    ERIC Educational Resources Information Center

    Malaika, Majid A.

    2011-01-01

    With today's high demand for online applications and services running on the Internet, software has become a vital component in our lives. With every revolutionary technology comes challenges unique to its characteristics; for online applications, security is one huge concern and challenge. Currently, there are several schemes that address…

  4. Aerospace applications of batteries

    NASA Technical Reports Server (NTRS)

    Habib, Shahid

    1993-01-01

    NASA has developed battery technology to meet the demanding requirements for aerospace applications; specifically, the space vacuum, launch loads, and high duty cycles. Because of unique requirements and operating environments associated with space applications, NASA has written its own standards and specifications for batteries.

  5. Network aware distributed applications

    SciTech Connect

    Agarwal, Deborah; Tierney, Brian L.; Gunter, Dan; Lee, Jason; Johnston, William

    2001-02-04

    Most distributed applications today manage to utilize only a small percentage of the needed and available network bandwidth. Often application developers are not aware of the potential bandwidth of the network, and therefore do not know what to expect. Even when application developers are aware of the specifications of the machines and network links, they have few resources that can help determine why the expected performance was not achieved. What is needed is a ubiquitous and easy-to-use service that provides reliable, accurate, secure, and timely estimates of dynamic network properties. This service will help advise applications on how to make use of the network's increasing bandwidth and capabilities for traffic shaping and engineering. When fully implemented, this service will make building currently unrealizable levels of network awareness into distributed applications a relatively mundane task. For example, a remote data visualization application could choose between sending a wireframe, a pre-rendered image, or a 3-D representation, based on forecasts of CPU availability and power, compression options, and available bandwidth. The same service will provide on-demand performance information so that applications can compare predicted with actual results, and allow detailed queries about the end-to-end path for application and network tuning and debugging.

  6. Applications of Solubility Data

    ERIC Educational Resources Information Center

    Tomkins, Reginald P. T.

    2008-01-01

    This article describes several applications of the use of solubility data. It is not meant to be exhaustive but rather to show that knowledge of solubility data is required in a variety of technical applications that assist in the design of chemical processes. (Contains 3 figures and 1 table.)

  7. Automatic multiple applicator electrophoresis

    NASA Technical Reports Server (NTRS)

    Grunbaum, B. W.

    1977-01-01

    Easy-to-use, economical device permits electrophoresis on all known supporting media. System includes automatic multiple-sample applicator, sample holder, and electrophoresis apparatus. System has potential applicability to fields of taxonomy, immunology, and genetics. Apparatus is also used for electrofocusing.

  8. NASA Applications Data Service

    NASA Technical Reports Server (NTRS)

    Brown, L. E.

    1979-01-01

    The NASA Applications Data Service (ADS), which is being developed to provide timely, affordable access to readily usable multisource data products and services for NASA-affliliated space-technology applications researchers, is presented. The system concept of a decentralized information network, which retrieves data from existing data bases and provides it to the user, has been adopted, and feasibility studies of the compatibility of the ADS with other existing or planned network data systems are under way. Other current efforts include the definition of the requirements and services necessary to support NASA applications experiments and encourage private industry to design the system and commercially implement it, as well as applications scenarios support, commercialization potential, standards identification, and concept justification with respect to future applications missions.

  9. International Space Station Environmental Control and Life Support System Acceptance Testing for the Pressurized Mating Adapters

    NASA Technical Reports Server (NTRS)

    Williams, David E.

    2008-01-01

    The International Space Station (ISS) Pressurized Mating Adapters (PMAs) Environmental Control and Life Support (ECLS) System is comprised of three subsystems: Atmosphere Control and Supply (ACS), Temperature and Humidity Control (THC), and Water Recovery and Management (WRM). PMAs 1 and 2 flew to ISS on Flight 2A and Pressurized Mating Adapter (PMA) 3 flew to ISS on Flight 3A. This paper provides a summary of the PMAs ECLS design and a detailed discussion of the ISS ECLS Acceptance Testing methodologies utilized for the PMAs.

  10. Stirling engine application study

    NASA Technical Reports Server (NTRS)

    Teagan, W. P.; Cunningham, D.

    1983-01-01

    A range of potential applications for Stirling engines in the power range from 0.5 to 5000 hp is surveyed. Over one hundred such engine applications are grouped into a small number of classes (10), with the application in each class having a high degree of commonality in technical performance and cost requirements. A review of conventional engines (usually spark ignition or Diesel) was then undertaken to determine the degree to which commercial engine practice now serves the needs of the application classes and to detemine the nature of the competition faced by a new engine system. In each application class the Stirling engine was compared to the conventional engines, assuming that objectives of ongoing Stirling engine development programs are met. This ranking process indicated that Stirling engines showed potential for use in all application classes except very light duty applications (lawn mowers, etc.). However, this potential is contingent on demonstrating much greater operating life and reliability than has been demonstrated to date by developmental Stirling engine systems. This implies that future program initiatives in developing Stirling engine systems should give more emphasis to life and reliability issues than has been the case in ongoing programs.

  11. Biomaterials and therapeutic applications

    NASA Astrophysics Data System (ADS)

    Ferraro, Angelo

    2016-03-01

    A number of organic and inorganic, synthetic or natural derived materials have been classified as not harmful for the human body and are appropriate for medical applications. These materials are usually named biomaterials since they are suitable for introduction into living human tissues of prosthesis, as well as for drug delivery, diagnosis, therapies, tissue regeneration and many other clinical applications. Recently, nanomaterials and bioabsorbable polymers have greatly enlarged the fields of application of biomaterials attracting much more the attention of the biomedical community. In this review paper I am going to discuss the most recent advances in the use of magnetic nanoparticles and biodegradable materials as new biomedical tools.

  12. Industrial application experiment series

    NASA Technical Reports Server (NTRS)

    Bluhm, S. A.

    1980-01-01

    The deployment of parabolic dish systems into the industrial sector for the purpose of providing users, suppliers, sponsors, and developers with a realistic assessment of system feasibility in selected near-term industrial applications will be accomplished initially through the industrial module experiment and later through additional experiments involving thermal, electric, and combined thermal and electrical systems. The approach is to progress through steps, from single module to multi-module systems, from thermal-only applications to more complex combined thermal and electric applications. The experience of other solar thermal experiments, particularly those involving parabolic dish hardware, will be utilized to the fullest extent possible in experiment planning and implementation.

  13. Wind energy applications guide

    SciTech Connect

    anon.

    2001-01-01

    The brochure is an introduction to various wind power applications for locations with underdeveloped transmission systems, from remote water pumping to village electrification. It includes an introductory section on wind energy, including wind power basics and system components and then provides examples of applications, including water pumping, stand-alone systems for home and business, systems for community centers, schools, and health clinics, and examples in the industrial area. There is also a page of contacts, plus two specific example applications for a wind-diesel system for a remote station in Antarctica and one on wind-diesel village electrification in Russia.

  14. Application Interoperability with SAMP

    NASA Astrophysics Data System (ADS)

    Fitzpatrick, M.; Laurino, O.; Paioro, L.; Taylor, M. B.

    2013-10-01

    The Simple Applications Messaging Protocol (SAMP) is a Virtual Observatory (VO) specification that enables astronomy software tools to exchange control information and data, allowing desktop applications to work as an integrated suite of tools rather than requiring complex functionality to be (redundantly) built into tools individually. In addition, SAMP allows new workflows to be created for the science user that leverages the advantages of each tool (e.g. visualization of tables or images, analysis, etc.), greatly reducing the time needed to switch between applications and tasks. We present here a short introduction to the protocol itself, a survey of some toolkits for application authors who wish to introduce SAMP functionality into their tools, and some examples of real-world usage.

  15. Photochemical Modeling Applications

    EPA Pesticide Factsheets

    Provides access to modeling applications involving photochemical models, including modeling of ozone, particulate matter (PM), and mercury for national and regional EPA regulations such as the Clean Air Interstate Rule (CAIR) and the Clean Air Mercury Rule

  16. Potential Applications for AQUATOX

    EPA Pesticide Factsheets

    AQUATOX has a myriad of potential applications to water management issues and programs, including water quality criteria and standards, TMDLs (Total Maximum Daily Loads), and ecological risk assessments of aquatic systems.

  17. Novel Applications of Computers

    ERIC Educational Resources Information Center

    Levi, Barbara G.

    1970-01-01

    Presents some novel applications of the computer to physics research. They include (1) a computer program for calculating Compton scattering, (2) speech simulation, (3) data analysis in spectrometry, and (4) measurement of complex alpha-particle spectrum. Bibliography. (LC)

  18. Neutron sources and applications

    SciTech Connect

    Price, D.L.; Rush, J.J.

    1994-01-01

    Review of Neutron Sources and Applications was held at Oak Brook, Illinois, during September 8--10, 1992. This review involved some 70 national and international experts in different areas of neutron research, sources, and applications. Separate working groups were asked to (1) review the current status of advanced research reactors and spallation sources; and (2) provide an update on scientific, technological, and medical applications, including neutron scattering research in a number of disciplines, isotope production, materials irradiation, and other important uses of neutron sources such as materials analysis and fundamental neutron physics. This report summarizes the findings and conclusions of the different working groups involved in the review, and contains some of the best current expertise on neutron sources and applications.

  19. Industrial applications of nanoparticles.

    PubMed

    Stark, W J; Stoessel, P R; Wohlleben, W; Hafner, A

    2015-08-21

    Research efforts in the past two decades have resulted in thousands of potential application areas for nanoparticles - which materials have become industrially relevant? Where are sustainable applications of nanoparticles replacing traditional processing and materials? This tutorial review starts with a brief analysis on what makes nanoparticles attractive to chemical product design. The article highlights established industrial applications of nanoparticles and then moves to rapidly emerging applications in the chemical industry and discusses future research directions. Contributions from large companies, academia and high-tech start-ups are used to elucidate where academic nanoparticle research has revolutionized industry practice. A nanomaterial-focused analysis discusses new trends, such as particles with an identity, and the influence of modern instrument advances in the development of novel industrial products.

  20. Food Applications and Regulation

    NASA Astrophysics Data System (ADS)

    Gálvez, Antonio; Abriouel, Hikmate; Omar, Nabil Ben; Lucas, Rosario

    This chapter deals with food applications of bacteriocins. Regulatory issues on the different possibilities for incorporating bacteriocins as bioprotectants are discussed. Specific applications of bacteriocins or bacteriocin-producing strains are described for main food categories, including milk and dairy products, raw meats, ready-to-eat meat and poultry products, fermented meats, fish and fish products or fermented fish. The last section of the chapter deals with applications in foods and beverages derived from plant materials, such as raw vegetable foods, fruits and fruit juices, cooked food products, fermented vegetable foods and ­fermented beverages. Results obtained for application of bacteriocins in combination with other hurdles are also discussed for each specific case, with a special emphasis on novel food packaging and food-processing technologies, such as irradiation, pulsed electric field treatments or high hydrostatic pressure treatment.

  1. Applications of supercritical fluids.

    PubMed

    Brunner, Gerd

    2010-01-01

    This review discusses supercritical fluids in industrial and near-to-industry applications. Supercritical fluids are flexible tools for processing materials. Supercritical fluids have been applied to mass-transfer processes, phase-transition processes, reactive systems, materials-related processes, and nanostructured materials. Some applications are already at industrial capacity, whereas others remain under development. In addition to extraction, application areas include impregnation and cleaning, multistage countercurrent separation, particle formation, coating, and reactive systems such as hydrogenation, biomass gasification, and supercritical water oxidation. Polymers are modified with supercritical fluids, and colloids and emulsions as well as nanostructured materials exhibit interesting phenomena when in contact with supercritical fluids that can be industrially exploited. For these applications to succeed, the properties of supercritical fluids in combination with the materials processed must be clearly determined and fundamental knowledge of the complex behavior must be made readily available.

  2. Space applications of superconductivity

    NASA Technical Reports Server (NTRS)

    Sullivan, D. B.; Vorreiter, J. W.

    1979-01-01

    Some potential applications of superconductivity in space are summarized, e.g., the use of high field magnets for cosmic ray analysis or energy storage and generation, space applications of digital superconducting devices, such as the Josephson switch and, in the future, a superconducting computer. Other superconducting instrumentation which could be used in space includes: low frequency superconducting sensors, microwave and infrared detectors, instruments for gravitational studies, and high-Q cavities for use as stabilizing elements in clocks and oscillators.

  3. Photovoltaic systems and applications

    SciTech Connect

    Not Available

    1982-01-01

    Abstracts are given of presentations given at a project review meeting held at Albuquerque, NM. The proceedings cover the past accomplishments and current activities of the Photovoltaic Systems Research, Balance-of-System Technology Development and System Application Experiments Projects at Sandia National Laboratories. The status of intermediate system application experiments and residential system analysis is emphasized. Some discussion of the future of the Photovoltaic Program in general, and the Sandia projects in particular is also presented.

  4. Programmable Logic Application Notes

    NASA Technical Reports Server (NTRS)

    Katz, Richard

    1998-01-01

    This column will be provided each quarter as a source for reliability, radiation results, NASA capabilities, and other information on programmable logic devices and related applications. This quarter's column will include some announcements and some recent radiation test results and evaluations of interest. Specifically, the following topics will be covered: the Military and Aerospace Applications of Programmable Devices and Technologies Conference to be held at GSFC in September, 1998, proton test results, and some total dose results.

  5. Aluminum powder applications

    SciTech Connect

    Gurganus, T.B.

    1995-08-01

    Aluminum powders have physical and metallurgical characteristics related to their method of manufacture that make them extremely important in a variety of applications. They can propel rockets, improve personal hygiene, increase computer reliability, refine exotic alloys, and reduce weight in the family sedan or the newest Air Force fighter. Powders formed into parts for structural and non-structural applications hold the key to some of the most exciting new developments in the aluminum future.

  6. Nanotubes in biological applications.

    PubMed

    Mundra, Ruchir V; Wu, Xia; Sauer, Jeremy; Dordick, Jonathan S; Kane, Ravi S

    2014-08-01

    Researchers over the last few years have recognized carbon nanotubes (CNTs) as promising materials for a number of biological applications. CNTs are increasingly being explored as potent drug carriers for cancer treatment, for biosensing, and as scaffolds for stem cell culture. Moreover, the integration of CNTs with proteins has led to the development of functional nanocomposites with antimicrobial properties. This review aims at understanding the critical role of CNTs in biological applications with a particular emphasis on more recent studies.

  7. Galileo Timing Applications

    DTIC Science & Technology

    2007-11-01

    Time Interval (PTTI) Meeting Intranet S Internet NetRecord NetRecord NetRecord Figure 11. NetRecorder and Trusted...Summary of application domains for the use of time in cryptography. B2G B2B B2C Applications Military waypoints, judicial reports, construction...document in different languages uses contradicting terms like “UTC,” “GMT,” and world time to refer to exactly the same thing • Individual countries

  8. Applications for alliform carbon

    DOEpatents

    Gogotsi, Yury; Mochalin, Vadym; McDonough, IV, John Kenneth; Simon, Patrice; Taberna, Pierre Louis

    2017-02-21

    This invention relates to novel applications for alliform carbon, useful in conductors and energy storage devices, including electrical double layer capacitor devices and articles incorporating such conductors and devices. Said alliform carbon particles are in the range of 2 to about 20 percent by weight, relative to the weight of the entire electrode. Said novel applications include supercapacitors and associated electrode devices, batteries, bandages and wound healing, and thin-film devices, including display devices.

  9. Programmable Logic Application Notes

    NASA Technical Reports Server (NTRS)

    Katz, Richard

    1998-01-01

    This column will be provided each quarter as a source for reliability, radiation results, NASA capabilities, and other information on programmable logic devices and related applications. This quarter's column will include some announcements and some recent radiation test results and evaluations of interest. Specifically, the following topics will be covered: the Military and Aerospace Applications of Programmable Devices and Technologies Conference to be held at GSFC in September, 1998, proton test results, heavy ion test results, and some total dose results.

  10. LCS Content Document Application

    NASA Technical Reports Server (NTRS)

    Hochstadt, Jake

    2011-01-01

    My project at KSC during my spring 2011 internship was to develop a Ruby on Rails application to manage Content Documents..A Content Document is a collection of documents and information that describes what software is installed on a Launch Control System Computer. It's important for us to make sure the tools we use everyday are secure, up-to-date, and properly licensed. Previously, keeping track of the information was done by Excel and Word files between different personnel. The goal of the new application is to be able to manage and access the Content Documents through a single database backed web application. Our LCS team will benefit greatly with this app. Admin's will be able to login securely to keep track and update the software installed on each computer in a timely manner. We also included exportability such as attaching additional documents that can be downloaded from the web application. The finished application will ease the process of managing Content Documents while streamlining the procedure. Ruby on Rails is a very powerful programming language and I am grateful to have the opportunity to build this application.

  11. Applications of electrospun fibers.

    PubMed

    Lu, Ping; Ding, Bin

    2008-01-01

    The simplicity of the electrospinning fabrication process, the diversity of electrospinnable materials, and the unique features associated with electrospun fibers make this technique and resultant structures attractive for various applications. The past few years witnessed the significant progresses in the application areas of electrospun fibers, which were demonstrated by the numbers of the recent published patents on electrospinning. It is very apparent that the current focus has been shifted from studying the modification of the electrospinning conditions and apparatus for obtaining fibers with different sizes, shapes, morphologies, structures, alignments before 2000 to looking for the possible applications of these resultant nanofibers with broad functionalities after 2001. The current paper presents a systematic review on the recent applications of electrospun nanofibers in a broad range of fields including biomedical applications such as drug delivery, tissue engineering, wound dressing and cosmetics, functional materials and devices such as composite reinforcement, filters, protective clothing and smart textiles, and energy and electronics such as batteries/cells and capacitors, sensors and catalysts. Although some of these applications may be still remained in the laboratory in the current stage, plenty of successful examples have proved that electrospun nanofibers have a bright future in a variety of industries.

  12. Applications of cavity optomechanics

    NASA Astrophysics Data System (ADS)

    Metcalfe, Michael

    2014-09-01

    "Cavity-optomechanics" aims to study the quantum properties of mechanical systems. A common strategy implemented in order to achieve this goal couples a high finesse photonic cavity to a high quality factor mechanical resonator. Then, using feedback forces such as radiation pressure, one can cool the mechanical mode of interest into the quantum ground state and create non-classical states of mechanical motion. On the path towards achieving these goals, many near-term applications of this field have emerged. After briefly introducing optomechanical systems and describing the current state-of-the-art experimental results, this article summarizes some of the more exciting practical applications such as ultra-sensitive, high bandwidth accelerometers and force sensors, low phase noise x-band integrated microwave oscillators and optical signal processing such as optical delay-lines, wavelength converters, and tunable optical filters. In this rapidly evolving field, new applications are emerging at a fast pace, but this article concentrates on the aforementioned lab-based applications as these are the most promising avenues for near-term real-world applications. New basic science applications are also becoming apparent such as the generation of squeezed light, testing gravitational theories and for providing a link between disparate quantum systems.

  13. Technology Applications Team: Applications of aerospace technology

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Highlights of the Research Triangle Institute (RTI) Applications Team activities over the past quarter are presented in Section 1.0. The Team's progress in fulfilling the requirements of the contract is summarized in Section 2.0. In addition to our market-driven approach to applications project development, RTI has placed increased effort on activities to commercialize technologies developed at NASA Centers. These Technology Commercialization efforts are summarized in Section 3.0. New problem statements prepared by the Team in the reporting period are presented in Section 4.0. The Team's transfer activities for ongoing projects with the NASA Centers are presented in Section 5.0. Section 6.0 summarizes the status of four add-on tasks. Travel for the reporting period is described in Section 7.0. The RTI Team staff and consultants and their project responsibilities are listed in Appendix A. The authors gratefully acknowledge the contributions of many individuals to the RTI Technology Applications Team program. The time and effort contributed by managers, engineers, and scientists throughout NASA were essential to program success. Most important to the program has been a productive working relationship with the NASA Field Center Technology Utilization (TU) Offices. The RTI Team continues to strive for improved effectiveness as a resource to these offices. Industry managers, technical staff, medical researchers, and clinicians have been cooperative and open in their participation. The RTI Team looks forward to continuing expansion of its interaction with U.S. industry to facilitate the transfer of aerospace technology to the private sector.

  14. Automated Inadvertent Intruder Application

    SciTech Connect

    Koffman, Larry D.; Lee, Patricia L.; Cook, James R.; Wilhite, Elmer L.

    2008-01-15

    The Environmental Analysis and Performance Modeling group of Savannah River National Laboratory (SRNL) conducts performance assessments of the Savannah River Site (SRS) low-level waste facilities to meet the requirements of DOE Order 435.1. These performance assessments, which result in limits on the amounts of radiological substances that can be placed in the waste disposal facilities, consider numerous potential exposure pathways that could occur in the future. One set of exposure scenarios, known as inadvertent intruder analysis, considers the impact on hypothetical individuals who are assumed to inadvertently intrude onto the waste disposal site. Inadvertent intruder analysis considers three distinct scenarios for exposure referred to as the agriculture scenario, the resident scenario, and the post-drilling scenario. Each of these scenarios has specific exposure pathways that contribute to the overall dose for the scenario. For the inadvertent intruder analysis, the calculation of dose for the exposure pathways is a relatively straightforward algebraic calculation that utilizes dose conversion factors. Prior to 2004, these calculations were performed using an Excel spreadsheet. However, design checks of the spreadsheet calculations revealed that errors could be introduced inadvertently when copying spreadsheet formulas cell by cell and finding these errors was tedious and time consuming. This weakness led to the specification of functional requirements to create a software application that would automate the calculations for inadvertent intruder analysis using a controlled source of input parameters. This software application, named the Automated Inadvertent Intruder Application, has undergone rigorous testing of the internal calculations and meets software QA requirements. The Automated Inadvertent Intruder Application was intended to replace the previous spreadsheet analyses with an automated application that was verified to produce the same calculations and

  15. Analysis of longitudinal laboratory data in the presence of common selection mechanisms: a view toward greater emphasis on pre-marketing pharmaceutical safety.

    PubMed

    Schildcrout, Jonathan S; Jenkins, Cathy A; Ostroff, Jack H; Gillen, Daniel L; Harrell, Frank E; Trost, Donald C

    2008-05-30

    Pharmaceutical safety has received substantial attention in the recent past; however, longitudinal clinical laboratory data routinely collected during clinical trials to derive safety profiles are often used ineffectively. For example, these data are frequently summarized by comparing proportions (between treatment arms) of participants who cross pre-specified threshold values at some time during follow-up. This research is intended, in part, to encourage more effective utilization of these data by avoiding unnecessary dichotomization of continuous data, acknowledging and making use of the longitudinal follow-up, and combining data from multiple clinical trials. However, appropriate analyses require careful consideration of a number of challenges (e.g. selection, comparability of study populations, etc.). We discuss estimation strategies based on estimating equations and maximum likelihood for analyses in the presence of three response history-dependent selection mechanisms: dropout, follow-up frequency, and treatment discontinuation. In addition, because clinical trials' participants usually represent non-random samples from target populations, we describe two sensitivity analysis approaches. All discussions are motivated by an analysis that aims to characterize the dynamic relationship between concentrations of a liver enzyme (alanine aminotransferase) and three distinct doses (no drug, low dose, and high dose) of an nk-1 antagonist across four Phase II clinical trials.

  16. Pre-market approval and post-market direct-to-consumer advertising of medical devices in Australia: a case study of breast cancer screening and diagnostic devices.

    PubMed

    Vreugdenburg, T D; Willis, C D; Mundy, L; Hiller, J E

    2013-01-01

    While research investigating direct-to-consumer advertising of therapeutic goods in Australia has historically focused on prescription medicines, recent action taken by regulators against companies promoting medical devices has placed the industry into the spotlight. Despite the need to effectively regulate direct-to-consumer advertising of medical devices due to its potential harms, inadequacies in the current regulatory system have been noted. Under the present system, devices with a questionable evidence base may enter the Australian marketplace without an evaluation of their effectiveness, and regulators are reliant on industry self-regulation and consumer complaints to draw attention to cases of advertising misconduct. Although some successes in the present system have been observed, we argue that the outlined inadequacies continue to enable the promotion of medical devices to consumers without thorough or sufficient examination of evidence.

  17. Multiphysics Application Coupling Toolkit

    SciTech Connect

    Campbell, Michael T.

    2013-12-02

    This particular consortium implementation of the software integration infrastructure will, in large part, refactor portions of the Rocstar multiphysics infrastructure. Development of this infrastructure originated at the University of Illinois DOE ASCI Center for Simulation of Advanced Rockets (CSAR) to support the center's massively parallel multiphysics simulation application, Rocstar, and has continued at IllinoisRocstar, a small company formed near the end of the University-based program. IllinoisRocstar is now licensing these new developments as free, open source, in hopes to help improve their own and others' access to infrastructure which can be readily utilized in developing coupled or composite software systems; with particular attention to more rapid production and utilization of multiphysics applications in the HPC environment. There are two major pieces to the consortium implementation, the Application Component Toolkit (ACT), and the Multiphysics Application Coupling Toolkit (MPACT). The current development focus is the ACT, which is (will be) the substrate for MPACT. The ACT itself is built up from the components described in the technical approach. In particular, the ACT has the following major components: 1.The Component Object Manager (COM): The COM package provides encapsulation of user applications, and their data. COM also provides the inter-component function call mechanism. 2.The System Integration Manager (SIM): The SIM package provides constructs and mechanisms for orchestrating composite systems of multiply integrated pieces.

  18. Nonlinear Optics and Applications

    NASA Technical Reports Server (NTRS)

    Abdeldayem, Hossin A. (Editor); Frazier, Donald O. (Editor)

    2007-01-01

    Nonlinear optics is the result of laser beam interaction with materials and started with the advent of lasers in the early 1960s. The field is growing daily and plays a major role in emerging photonic technology. Nonlinear optics play a major role in many of the optical applications such as optical signal processing, optical computers, ultrafast switches, ultra-short pulsed lasers, sensors, laser amplifiers, and many others. This special review volume on Nonlinear Optics and Applications is intended for those who want to be aware of the most recent technology. This book presents a survey of the recent advances of nonlinear optical applications. Emphasis will be on novel devices and materials, switching technology, optical computing, and important experimental results. Recent developments in topics which are of historical interest to researchers, and in the same time of potential use in the fields of all-optical communication and computing technologies, are also included. Additionally, a few new related topics which might provoke discussion are presented. The book includes chapters on nonlinear optics and applications; the nonlinear Schrodinger and associated equations that model spatio-temporal propagation; the supercontinuum light source; wideband ultrashort pulse fiber laser sources; lattice fabrication as well as their linear and nonlinear light guiding properties; the second-order EO effect (Pockels), the third-order (Kerr) and thermo-optical effects in optical waveguides and their applications in optical communication; and, the effect of magnetic field and its role in nonlinear optics, among other chapters.

  19. Applications of aerospace technology

    NASA Technical Reports Server (NTRS)

    Rouse, Doris J.

    1984-01-01

    The objective of the Research Triangle Institute Technology Transfer Team is to assist NASA in achieving widespread utilization of aerospace technology in terrestrial applications. Widespread utilization implies that the application of NASA technology is to benefit a significant sector of the economy and population of the Nation. This objective is best attained by stimulating the introduction of new or improved commercially available devices incorporating aerospace technology. A methodology is presented for the team's activities as an active transfer agent linking NASA Field Centers, industry associations, user groups, and the medical community. This methodology is designed to: (1) identify priority technology requirements in industry and medicine, (2) identify applicable NASA technology that represents an opportunity for a successful solution and commercial product, (3) obtain the early participation of industry in the transfer process, and (4) successfully develop a new product based on NASA technology.

  20. Data management applications

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Kennedy Space Center's primary institutional computer is a 4 megabyte IBM 4341 with 3.175 billion characters of IBM 3350 disc storage. This system utilizes the Software AG product known as ADABAS with the on line user oriented features of NATURAL and COMPLETE as a Data Base Management System (DBMS). It is operational under the OS/VSI and is currently supporting batch/on line applications such as Personnel, Training, Physical Space Management, Procurement, Office Equipment Maintenance, and Equipment Visibility. A third and by far the largest DBMS application is known as the Shuttle Inventory Management System (SIMS) which is operational on a Honeywell 6660 (dedicated) computer system utilizing Honeywell Integrated Data Storage I (IDSI) as the DBMS. The SIMS application is designed to provide central supply system acquisition, inventory control, receipt, storage, and issue of spares, supplies, and materials.

  1. APTASENSORS FOR BIOSECURITY APPLICATIONS

    SciTech Connect

    Fischer, N; Tarasow, T; Tok, J

    2007-01-03

    Nucleic acid aptamers have found steadily increased utility and application steadily over the last decade. In particular, aptamers have been touted as a valuable complement to and in some cases replacement for antibodies due to their structural and functional robustness as well as their ease in generation and synthesis. They are thus attractive for biosecurity applications, e.g. pathogen detection, and are especially well suited since their in vitro generation process does not require infection of any host systems. Herein we provide a brief overview of the aptamers generated against biopathogens over the last few years. In addition, a few recently described detection platforms using aptamers (aptasensors) and potentially suitable for biosecurity applications will be discussed.

  2. Medical devices: US medical device regulation.

    PubMed

    Jarow, Jonathan P; Baxley, John H

    2015-03-01

    Medical devices are regulated by the US Food and Drug Administration (FDA) within the Center for Devices and Radiological Health. Center for Devices and Radiological Health is responsible for protecting and promoting the public health by ensuring the safety, effectiveness, and quality of medical devices, ensuring the safety of radiation-emitting products, fostering innovation, and providing the public with accurate, science-based information about the products we oversee, throughout the total product life cycle. The FDA was granted the authority to regulate the manufacturing and marketing of medical devices in 1976. It does not regulate the practice of medicine. Devices are classified based on complexity and level of risk, and "pre-1976" devices were allowed to remain on the market after being classified without FDA review. Post-1976 devices of lower complexity and risk that are substantially equivalent to a marketed "predicate" device may be cleared through the 510(k) premarket notification process. Clinical data are typically not needed for 510(k) clearance. In contrast, higher-risk devices typically require premarket approval. Premarket approval applications must contain data demonstrating reasonable assurance of safety and efficacy, and this information typically includes clinical data. For novel devices that are not high risk, the de novo process allows FDA to simultaneously review and classify new devices. Devices that are not legally marketed are permitted to be used for clinical investigation purposes in the United States under the Investigational Device Exemptions regulation.

  3. Clinical applications of magnetoencephalography.

    PubMed

    Stufflebeam, Steven M; Tanaka, Naoaki; Ahlfors, Seppo P

    2009-06-01

    Magnetoencephalography (MEG), in which magnetic fields generated by brain activity are recorded outside of the head, is now in routine clinical practice throughout the world. MEG has become a recognized and vital part of the presurgical evaluation of patients with epilepsy and patients with brain tumors. We review investigations that show an improvement in the postsurgical outcomes of patients with epilepsy by localizing epileptic discharges. We also describe the most common clinical MEG applications that affect the management of patients, and discuss some applications that are close to having a clinical impact on patients.

  4. Microgravity Science and Applications

    NASA Technical Reports Server (NTRS)

    1986-01-01

    The report presents fifteen papers from a workshop on microgravity science and applications held at the Jet Propulsion Laboratory in Pasadena, California, on December 3 to 4, 1984. The workshop and panel were formed by the Solid State Sciences Committee of the Board on Physics and Astronomy of the National Research Council in response to a request from the Office of Science and Technology Policy. The goal was to review the microgravity science and applications (MSA) program of NASA and to evaluate the quality of the program. The topics for the papers are metals and alloys, electronic materials, ceramics and glasses, biotechnology, combustion science, and fluid dynamics.

  5. Applications Spacelab missions

    NASA Technical Reports Server (NTRS)

    Pellerin, C. J., Jr.

    1979-01-01

    The paper presents the plans of the Office of Space and Terrestrial Applications for the Shuttle/Spacelab missions. It is reported that the current program contains dedicated low-gravity mission (Spacelab 3 mission) and several minor missions planned for flight during 1980-1982. It is noted that these missions have either Materials Processing or Earth viewing emphasis. Finally, several representative experiments are used to illustrate the Applications Spacelab Program, such as the Materials Experiment Assembly (MEA), and the Atmospheric Trace Molecule Measured by Spectroscopy (ATMOS) experiment.

  6. Polyimide composites: Application histories

    NASA Technical Reports Server (NTRS)

    Poveromo, L. M.

    1985-01-01

    Advanced composite hardware exposed to thermal environments above 127 C (260 F) must be fabricated from materials having resin matrices whose thermal/moisture resistance is superior to that of conventional epoxy-matrix systems. A family of polyimide resins has evolved in the last 10 years that exhibits the thermal-oxidative stability required for high-temperature technology applications. The weight and structural benefits for organic-matrix composites can now be extended by designers and materials engineers to include structures exposed to 316 F (600 F). Polyimide composite materials are now commercially available that can replace metallic or epoxy composite structures in a wide range of aerospace applications.

  7. Science Application Teams

    NASA Technical Reports Server (NTRS)

    2000-01-01

    This paper discusses the science application team activities. Science Application team are: (1) Represent the diversity of NASA onboard computing of the future. (2) Drive architecture and system software requirements. (3) Demonstrate the benefit of highly capable computing onboard. (4) Study the birth of the first galaxies. (5) Study formation of stars. (6) Discusses the next generation space telescope hardware/software requirement: image processing and on-board optical calibration. Also discusses gamma ray large area space telescope; orbital thermal imaging spectrometer; solar terrestrial probe program; autonomous Mars rover;fault tolerance and errors.

  8. Location Based Application Availability

    NASA Astrophysics Data System (ADS)

    Naeem Akram, Raja; Markantonakis, Konstantinos; Mayes, Keith

    Smart cards are being integrated into a diverse range of industries: ranging from banking, telecom, transport, home/office access control to health and E-passport. Traditionally, cardholders are required to carry a smart card for each application. However, recent developments in the Near Field Communication (NFC) have renewed the interest in multiple applications for different services on a single device. This paper builds onto the NFC initiative and avoids the smart card ownership issues that hinder the adoption of such devices. The proposal integrates the Global Positioning System with the NFC in mobile phones to provide a ubiquitously and flexible service access model.

  9. National information infrastructure applications

    SciTech Connect

    Forslund, D.; George, J.; Greenfield, J.

    1996-07-01

    This is the final report of a two-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). This project sought to develop a telemedical application in which medical records are electronically searched and digital signatures of real CT scan data are indexed and used to characterize a range of diseases and are used to compare on-line medical data with archived clinical data rapidly. This system includes multimedia data management, interactive collaboration, data compression and transmission, remote data storage and retrieval, and automated data analysis integrated in a distributed application between Los Alamos and the National Jewish Hospital.

  10. Future communications satellite applications

    NASA Technical Reports Server (NTRS)

    Bagwell, James W.

    1992-01-01

    The point of view of the research is made through the use of viewgraphs. It is suggested that future communications satellite applications will be made through switched point to point narrowband communications. Some characteristics of which are as follows: small/low cost terminals; single hop communications; voice compatible; full mesh networking; ISDN compatible; and possible limited use of full motion video. Some target applications are as follows: voice/data networks between plants and offices in a corporation; data base networking for commercial and science users; and cellular radio internodal voice/data networking.

  11. Applications Using AIRS Data

    NASA Astrophysics Data System (ADS)

    Ray, S. E.; Pagano, T. S.; Fetzer, E. J.; Lambrigtsen, B.; Olsen, E. T.; Teixeira, J.; Licata, S. J.; Hall, J. R.; Thompson, C. K.

    2015-12-01

    The Atmospheric Infrared Sounder (AIRS) on NASA's Aqua spacecraft has been returning daily global observations of Earth's atmospheric constituents and properties since 2002. With a 12-year data record and daily, global observations in near real-time, AIRS data can play a role in applications that fall under many of the NASA Applied Sciences focus areas. For vector-borne disease, research is underway using AIRS near surface retrievals to assess outbreak risk, mosquito incubation periods and epidemic potential for dengue fever, malaria, and West Nile virus. For drought applications, AIRS temperature and humidity data are being used in the development of new drought indicators and improvement in the understanding of drought development. For volcanic hazards, new algorithms using AIRS data are in development to improve the reporting of sulfur dioxide concentration, the burden and height of volcanic ash and dust, all of which pose a safety threat to aircraft. In addition, anomaly maps of many of AIRS standard products are being produced to help highlight "hot spots" and illustrate trends. To distribute it's applications imagery, AIRS is leveraging existing NASA data frameworks and organizations to facilitate archiving, distribution and participation in the BEDI. This poster will communicate the status of the applications effort for the AIRS Project and provide examples of new maps designed to best communicate the AIRS data.

  12. Applications of Superconductivity

    ERIC Educational Resources Information Center

    Goodkind, John M.

    1971-01-01

    Presents a general review of current practical applications of the properties of superconducters. The devices are classified into groups according to the property that is of primary importance. The article is inteded as a first introduction for students and professionals. (Author/DS)

  13. Transducer applications, a compilation

    NASA Technical Reports Server (NTRS)

    1972-01-01

    The characteristics and applications of transducers are discussed. Subjects presented are: (1) thermal measurements, (2) liquid level and fluid flow measurements, (3) pressure transducers, (4) stress-strain measurements, (5) acceleration and velocity measurements, (6) displacement and angular rotation, and (7) transducer test and calibration methods.

  14. Business Applications of WAP.

    ERIC Educational Resources Information Center

    van Steenderen, Margaret

    2002-01-01

    Explains the development of WAP (wireless application protocol), how it works, and what the major advantages and disadvantages are, especially when applied to the use of information. Topics include standardization; mobile communications; the effect of WAP on business tools, electronic commerce, and information services; consumers; corporate users;…

  15. Forensic Applications of LIBS

    NASA Astrophysics Data System (ADS)

    Hark, Richard R.; East, Lucille J.

    Forensic science is broadly defined as the application of science to matters of the law. Practitioners typically use multidisciplinary scientific techniques for the analysis of physical evidence in an attempt to establish or exclude an association between a suspect and the scene of a crime.

  16. Biomedical applications engineering tasks

    NASA Technical Reports Server (NTRS)

    Laenger, C. J., Sr.

    1976-01-01

    The engineering tasks performed in response to needs articulated by clinicians are described. Initial contacts were made with these clinician-technology requestors by the Southwest Research Institute NASA Biomedical Applications Team. The basic purpose of the program was to effectively transfer aerospace technology into functional hardware to solve real biomedical problems.

  17. Programmable Logic Application Notes

    NASA Technical Reports Server (NTRS)

    Katz, Richard

    2000-01-01

    This column will be provided each quarter as a source for reliability, radiation results, NASA capabilities, and other information on programmable logic devices and related applications. This quarter will start a series of notes concentrating on analysis techniques with this issues section discussing worst-case analysis requirements.

  18. Programmable Logic Application Notes

    NASA Technical Reports Server (NTRS)

    Katz, Richard; Day, John H. (Technical Monitor)

    2001-01-01

    This report will be provided each quarter as a source for reliability, radiation results, NASA capabilities, and other information on programmable logic devices and related applications. This quarter will continue a series of notes concentrating on analysis techniques with this issue's section discussing the use of Root-Sum-Square calculations for digital delays.

  19. Permit application modifications

    SciTech Connect

    1995-11-01

    This document contains the Permit Application Modifications for the Y-12 Industrial Landfill V site on the Oak Ridge Reservation. These modifications include the assessment of stability of the proposed Landfill V under static and loading conditions. Analyses performed include the general slope stability, veneer stability of the bottom liner and cover system, and a liquefaction potential assessment of the foundation soils.

  20. Clinical Application of Electrocardiography.

    ERIC Educational Resources Information Center

    Brammell, H. L.; Orr, William

    The scalar electrocardiogram (ECG) is one of the most important and commonly used clinical tools in medicine. A detailed description of the recordings of cardiac electrical activity made by the ECG is presented, and the vast numbers of uses made with the data provided by this diagnostic tool are cited. Clinical applications of the ECG are listed.…

  1. Computer applications in bioprocessing.

    PubMed

    Bungay, H R

    2000-01-01

    Biotechnologists have stayed at the forefront for practical applications for computing. As hardware and software for computing have evolved, the latest advances have found eager users in the area of bioprocessing. Accomplishments and their significance can be appreciated by tracing the history and the interplay between the computing tools and the problems that have been solved in bioprocessing.

  2. Applications of kinetic theory

    SciTech Connect

    Gidaspow, D.

    1992-01-01

    The overall objective of this investigation is to develop experimentally verified models for circulating fluidized bed (CFB) combustors. This report presents the author's derivation of analytical solutions useful in understanding the operation of a CFB. The report is in a form of a chapter that reviews the kinetic theory applications.

  3. VCSEL Applications and Simulation

    NASA Technical Reports Server (NTRS)

    Cheung, Samson; Goorjian, Peter; Ning, Cun-Zheng; Li, Jian-Zhong

    2000-01-01

    This viewgraph presentation gives an overview of Vertical Cavity Surface Emitting Laser (VCSEL) simulation and its applications. Details are given on the optical interconnection in information technology of VCSEL, the formulation of the simulation, its numeric algorithm, and the computational results.

  4. TIGER Arc Modification Application

    SciTech Connect

    Armstrong, Hillary

    1995-03-06

    The application enables the geometric correction of TIGER arcs to a more accurate spatial data set. This is done in a structured automated environment according to Census Bureau guidelines and New Mexico state GIS standards. Arcs may be deleted, added, combined, split, and moved relative to a coverage or image displayed in the background.

  5. Arizona's Application Service Provider.

    ERIC Educational Resources Information Center

    Jordan, Darla

    2002-01-01

    Describes the U.S.'s first statewide K-12 application service provider (ASP). The ASP, implemented by the Arizona School Facilities Board, provides access to productivity, communications, and education software programs from any Internet-enabled device, whether in the classroom or home. (EV)

  6. Microcontroller for automation application

    NASA Technical Reports Server (NTRS)

    Cooper, H. W.

    1975-01-01

    The description of a microcontroller currently being developed for automation application was given. It is basically an 8-bit microcomputer with a 40K byte random access memory/read only memory, and can control a maximum of 12 devices through standard 15-line interface ports.

  7. 10 CFR 611.100 - Eligible applicant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... applicant's debt-to-equity ratio as of the date of the loan application; (2) The applicant's earnings before... to the date of the loan application; (3) The applicant's debt to EBITDA ratio as of the date of the... application; (6) The applicant's liquidity as of the date of the loan application; (7) Statements...

  8. Novel Applications of Peroxidase

    NASA Astrophysics Data System (ADS)

    Rob, Abdul; Ball, Andrew S.; Tuncer, Munir; Wilson, Michael T.

    1997-02-01

    The article entitled "Novel Biocatalysts Will Work Even Better for Industry" published recently in this Journal (1) was informative and interesting. However it touched only briefly on the application of peroxidase as catalyst. Here, we would like to mention in more detail the novel applications of peroxidase in agricultural, paper pulp, water treatment, pharmaceutical, and medical situations. Firstly, the peroxidase isolated from Phanerochaete chyrosporium has been shown to detoxify herbicides such as atrazine to less toxic compounds and would certainly find potential application in agriculture (2). Secondly, the peroxidase produced by Streptomyces thermoviolaceus may find application in the paper pulp industry as a delignifying agent (3). Thirdly, it has been shown that extracellular peroxidase produced by Streptomyces avermitilis can remove the intense color from paper-mill effluent obtained after semichemical alkaline pulping of wheat straw (4), and thus this enzyme might find application as a catalyst in water treatment plants. Fourthly, the heme-containing horseradish peroxidase enzyme has been exploited in several diagnostic applications in pharmaceutics and medicine, such as the detection of human immunodeficiency virus and cystic fibrosis (5-10). Finally, recent work from our laboratory has suggested that thermophilic nonheme peroxidase produced by Thermomonospora fusca BD25 may find medical use in the diagnosis of myocardial infarction (11, 12). Literature Cited 1. Wiseman, A. J. Chem. Educ. 1996, 73, 55-58. 2. Mougin, C. Appl. Environ. Microbiol. 1994, 60, 705-708. 3. McCarthy A. J.; Peace, W.; Broda, P. Appl. Microbiol. Technol. 1985, 23, 238-244. 4. Hernandez, M; Rodriguez J; Soliveri, J; Copa, J. L; Perez, M. I; Arias, M. E. Appl. Environ. Microbiol. 1994, 60, 3909-3913. 5. Hopfer, S. M.; Aslanzadeh, J. Ann. Clin. Lab. Sci. 1995, 25, 475-480. 6. Suzuki, K; Iman, M. J. Virol. Methods 1995, 55, 347-356. 7. Nielsen, K. J. Immunoassay 1995, 16, 183-197. 8

  9. Nattokinase: production and application.

    PubMed

    Dabbagh, Fatemeh; Negahdaripour, Manica; Berenjian, Aydin; Behfar, Abdolazim; Mohammadi, Fatemeh; Zamani, Mozhdeh; Irajie, Cambyz; Ghasemi, Younes

    2014-11-01

    Nattokinase (NK, also known as subtilisin NAT) (EC 3.4.21.62) is one of the most considerable extracellular enzymes produced by Bacillus subtilis natto. The main interest about this enzyme is due to its direct fibrinolytic activity. Being stable enough in the gastrointestinal tract makes this enzyme a useful agent for the oral thrombolytic therapy. Thus, NK is regarded as a valuable dietary supplement or nutraceutical. Proven safety and ease of mass production are other advantages of this enzyme. In addition to these valuable advantages, there are other applications attributed to NK including treatment of hypertension, Alzheimer's disease, and vitreoretinal disorders. This review tends to bring a brief description about this valuable enzyme and summarizes the various biotechnological approaches used in its production, recovery, and purification. Some of the most important applications of NK, as well as its future prospects, are also discussed.

  10. Biochemiluminescence and biomedical applications.

    PubMed

    Champiat, D; Roux, A; Lhomme, O; Nosenzo, G

    1994-12-01

    Although used for analytical purposes for more than 40 years it is only recently that biochemiluminescence (BCL) has found widespread acceptance. Methods employing BCL reactions now play an important role in biomedical research and laboratory medicine. The main attractions for the assay technology include exquisite sensitivity (attomole-zeptomole), high selectivity, speed and simplicity. In biomedical research, the most important applications of BCL are: (1) to estimate microbial numbers and to assess cellular states (e.g., after exposure to antibiotic or cytotoxic agents) and in reporter gene studies (firefly luciferase gene); (2) NAD(P)H involved in redox/dehydrogenase studies using Vibrio luciferase complex; (3) BCL labels and CL detection of enzyme labels in immunoassays are the most widespread routine application for this technology. BCL enzyme immunoassays represent the most active area of development, e.g., enhanced BCL method for peroxidase and BCL assays for alkaline phosphatase labels using adamantyl 1,2-dioxetane.

  11. NASA: Biomedical applications team

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The status of projects involving the adaptation of NASA technologies for medical purposes is reviewed. Devices for the measurement of joint deformation of arthritic hands, the development of an artificial pancreas, provision of an auditory signal to avert epileptic seizures, are described along with the control of medication levels, a compressed air tank to supply power for field dentistry, and an electroencephalogram monitor. The use of the Lixiscope as a portable fluoroscope, thermal laminates for hand and foot warmers for patients with Raynaud's syndrome, and the use of absorptive coatings for instruments for controlling medication levels are described. The applicability of occupation health and safety practices to industry, computerized patient scheduling, impregnation of the common facial tissue with an agent for killing respiratory viruses, commercial applications of anthropometric data, and multispectral image analysis of the skin as a diagnostic tool are reviewed.

  12. Ceramics for fusion applications

    SciTech Connect

    Clinard, F.W. Jr.

    1986-01-01

    Ceramics are required for a variety of uses in both near-term fusion devices and in commercial powerplants. These materials must retain adequate structural and electrical properties under conditions of neutron, particle, and ionizing irradiation; thermal and applied stresses; and physical and chemical sputtering. Ceramics such as Al/sub 2/O/sub 3/, MgAl/sub 2/O/sub 4/, BeO, Si/sub 3/N/sub 4/ and SiC are currently under study for fusion applications, and results to date show widely-varying response to the fusion environment. Materials can be identified today which will meet initial operating requirements, but improvements in physical properties are needed to achieve satisfactory lifetimes for critical applications.

  13. Glyconanomaterials for biosensing applications.

    PubMed

    Hao, Nanjing; Neranon, Kitjanit; Ramström, Olof; Yan, Mingdi

    2016-02-15

    Nanomaterials constitute a class of structures that have unique physiochemical properties and are excellent scaffolds for presenting carbohydrates, important biomolecules that mediate a wide variety of important biological events. The fabrication of carbohydrate-presenting nanomaterials, glyconanomaterials, is of high interest and utility, combining the features of nanoscale objects with biomolecular recognition. The structures can also produce strong multivalent effects, where the nanomaterial scaffold greatly enhances the relatively weak affinities of single carbohydrate ligands to the corresponding receptors, and effectively amplifies the carbohydrate-mediated interactions. Glyconanomaterials are thus an appealing platform for biosensing applications. In this review, we discuss the chemistry for conjugation of carbohydrates to nanomaterials, summarize strategies, and tabulate examples of applying glyconanomaterials in in vitro and in vivo sensing applications of proteins, microbes, and cells. The limitations and future perspectives of these emerging glyconanomaterials sensing systems are furthermore discussed.

  14. Glyconanomaterials for Biosensing Applications

    PubMed Central

    Hao, Nanjing; Neranon, Kitjanit

    2015-01-01

    Nanomaterials constitute a class of structures that have unique physiochemical properties and are excellent scaffolds for presenting carbohydrates, important biomolecules that mediate a wide variety of important biological events. The fabrication of carbohydrate-presenting nanomaterials, glyconanomaterials, is of high interest and utility, combining the features of nanoscale objects with biomolecular recognition. The structures can also produce strong multivalent effects, where the nanomaterial scaffold greatly enhances the relatively weak affinities of single carbohydrate ligands to the corresponding receptors, and effectively amplifies the carbohydrate-mediated interactions. Glyconanomaterials are thus an appealing platform for biosensing applications. In this review, we discuss the chemistry for conjugation of carbohydrates to nanomaterials, summarize strategies, and tabulate examples of applying glyconanomaterials in in vitro and in vivo sensing applications of proteins, microbes, and cells. The limitations and future perspectives of these emerging glyconanomaterials sensing systems are furthermore discussed. PMID:26212205

  15. QMRPACK and applications

    SciTech Connect

    Freund, R.W.; Nachtigal, N.M.

    1994-10-01

    QMRPACK is a package of quasi-minimal residual algorithms for the iterative solution of linear systems. In this paper, the authors describe the main features of QMRPACK, comment on the implementations found in the package, and discuss how they would be invoked in a user code. They briefly describe two applications of the codes in the area of simulation of material properties from first principles, and in circuit simulation. They conclude by presenting future directions for QMRPACK.

  16. 1994 Technology Applications Report

    DTIC Science & Technology

    1994-01-01

    converting the oxygen to an active form that kills the cancer cells. Another system, still in the research stage, will be used in fertility...chemical company for improved honeycomb-based ceramics for industrial catalytic converters . ABOUT THE TECHNOLOGY HfMI develops new molding, forming...other areas as well. .Developers, in turn, have converted their BMDO sensor products to commercial uses such as oil drilling and automotive applications

  17. Glyconanoparticles for biomedical applications.

    PubMed

    Dong, Chang-Ming

    2011-03-01

    Over the past two decades, glycosylated nanoparticles (i.e., glyconanoparticles having sugar residues on the surface) received much attention for biomedical applications such as bioassays and targeted drug delivery. This minireview focuses on three aspects: (1) glycosylated gold nanoparticles, (2) glycosylated quantum dots, and (3) glyconanoparticles self-assembled from amphiphilic glycopolymers. The synthetic methods and the multivalent interactions between glyconanoparticles and lectins is shortly illustrated.

  18. Baltimore applications project

    NASA Technical Reports Server (NTRS)

    Golden, T. S.; Yaffee, P.

    1978-01-01

    The Baltimore Applications Project (BAP) was originally designed as an experimental effort to assist the government of the City of Baltimore in applying technology to the solution of municipal problems. Recent modifications in the structuring and operation of the program are discussed. A tabular update on the individual tasks undertaken and their treatment is provided. Details of energy and nonenergy related tasks are presented in appendices.

  19. Applications of ionic liquids.

    PubMed

    Patel, Divia Dinesh; Lee, Jong-Min

    2012-06-01

    Ionic liquids have recently gained popularity in the scientific community owing to their special properties and characteristics. One of the reasons why ionic liquids have been termed "green solvents" is due to their negligible vapour pressure. Their use in electrochemical, biological and metal extraction applications is discussed. Wide research has been carried out for their use in batteries, solar panels, fuel cells, drug deliveries and biomass pretreatments. This work aims to consolidate the various findings from previous works in these areas.

  20. Biomedical applications of photochemistry.

    PubMed

    Chan, Barbara Pui

    2010-10-01

    Photochemistry is the study of photochemical reactions between light and molecules. Recently, there have been increasing interests in using photochemical reactions in the fields of biomaterials and tissue engineering. This work revisits the components and mechanisms of photochemistry and reviews biomedical applications of photochemistry in various disciplines, including oncology, molecular biology, and biosurgery, with particular emphasis on tissue engineering. Finally, potential toxicities and research opportunities in this field are discussed.

  1. AGU membership applications

    NASA Astrophysics Data System (ADS)

    Applications for membership have been received from the following individuals. The letter after the name denotes the proposed primary section affiliation.Aubrey L. Anderson (O), Lennart A. Anderson (V), Kathleen W. Baird (V), William R. Bergmann (A), E. N. Bernard (O), Joyce R. Blueford (O), Wayne M. Brewer (T), Nancy Ann Brewster (O), Philip S. Callahan (O), Jack G. Calvert (A), Drew A. Carey (O), Benjamin Chen (O), J. W. Cole (V), George Courtney (T), Charles G. Crawford (H).

  2. ARM for Platform Application

    NASA Astrophysics Data System (ADS)

    Patte, Mathieu; Poupat, Jean-Luc; Le Meur, Patrick

    2015-09-01

    The activities described in this paper are part of the CNES R&T “Study of a Cortex-R ARM based architecture” performed by Airbus DS Space System & Electronics in 2014. With the support of CNES, Airbus DS has performed the porting of a representative space application software on an ARM based demonstration platform. This paper presents the platform itself, the activities performed at software level and the first results on this evaluation study.

  3. Oxide Films RF Applications

    DTIC Science & Technology

    2006-06-01

    different stabilities and properties . Certain applications, such as integrated dielectrics or photoelectrochemical cells, require thin films of TiO2 that...interesting dielectric properties . Another is that the (001) plane of anatase TiO2 is one of the two main layers stacked along the (100) direction in...Public Release 13. SUPPLEMENTARY NOTES .bDib ibuUl I U 1 iited 14. ABSTRACT TiO2 films were grown using a reactive molecular beam epitaxy system

  4. Advanced Welding Applications

    NASA Technical Reports Server (NTRS)

    Ding, Robert J.

    2010-01-01

    Some of the applications of advanced welding techniques are shown in this poster presentation. Included are brief explanations of the use on the Ares I and Ares V launch vehicle and on the Space Shuttle Launch vehicle. Also included are microstructural views from four advanced welding techniques: Variable Polarity Plasma Arc (VPPA) weld (fusion), self-reacting friction stir welding (SR-FSW), conventional FSW, and Tube Socket Weld (TSW) on aluminum.

  5. Opportunities for PV applications

    NASA Technical Reports Server (NTRS)

    Scott-Monck, John A.; Rahilly, W. Patrick

    1987-01-01

    Workshop members devoted the majority of time to discussing future prospects for technology support of photovoltaic applications. Photovoltaics has provided power for almost every spacecraft launched in the free world in the last 25 years. Over this time, photovoltaics has demonstrated impressive growth in power level, operating lifetime and specific power (W/kg and W/square m). Yet, the current attitude toward this reliable form of space power generation is likely to preclude further dramatic performance gains.

  6. Fresnel lens light applicator

    SciTech Connect

    Castel, J.C.; Kerwin, R.G.

    1987-09-01

    A therapeutic laser radiation applicator is described which consists of: means for providing laser radiation in an elliptical transverse distribution; and means for converting the elliptical transverse distribution of the laser radiation into a circular distribution thereof comprising at least two axially spaced fresnel lenses, and means for mounting the fresnel lenses in preselected association with the laser radiation means for refracting a portion of a laser radiation to the circular distribution adapted to provide a therapeutic tissue irradiation pattern.

  7. Agricultural application of SWECS

    NASA Astrophysics Data System (ADS)

    Nelson, V.

    Principal applications of wind energy for agriculture are (1) farmstead power, mainly electrical, (2) building heating, (3) irrigation pumping, (4) product storage and processing, (5) hot water for residences and dairies, and (6) associated industries of agribusiness such as feedlots, fertilizer elevators, greenhouses, etc. Field experiments show that wind energy is a viable alternative, however, reliability and maintenance are still major problems. Test results of the various experiments are described.

  8. Newton polyhedron and applications

    SciTech Connect

    Bruno, A.D.

    1994-12-31

    We give a simple presentation of an algorithm of selecting asymptotical first approximations of equations (algebraic and ordinary differential and partial differential). Here the first approximation of a solution of the initial equation is a solution of the corresponding first approximation of the equation. The algorithm is based on the geometry of power exponents including the Newton polyhedron. We give also a survey of applications of the algorithm in problems of Celestial Mechanics and Hydrodynamics.

  9. Space vehicle accelerometer applications

    NASA Technical Reports Server (NTRS)

    1972-01-01

    The physics of accelerometer applications are reviewed, and details are given on accelerometer instruments and the principles of their operations. The functions to which accelerometers are applied are listed, and terms commonly used in accelerometer reports are defined. Criteria guides state what rule, limitation, or standard must be imposed on each essential design element to insure successful design. Elaboration of these criteria in the form of recommended practices show how to satisfy each of these criteria, with the best procedure described when possible.

  10. 40 CFR 194.15 - certification application(s).

    Code of Federal Regulations, 2010 CFR

    1996-07-01

    ... ISOLATION PILOT PLANT'S COMPLIANCE WITH THE 40 CFR PART 191 DISPOSAL REGULATIONS Compliance Certification and Re-certification Applications Sec. 194.15 Content of compliance re-certification application(s... Sec. 194.15 Content of compliance re PROTECTION OF ENVIRONMENT ENVIRONMENTAL PROTECTION...

  11. Transactional Network Platform: Applications

    SciTech Connect

    Katipamula, Srinivas; Lutes, Robert G.; Ngo, Hung; Underhill, Ronald M.

    2013-10-31

    In FY13, Pacific Northwest National Laboratory (PNNL) with funding from the Department of Energy’s (DOE’s) Building Technologies Office (BTO) designed, prototyped and tested a transactional network platform to support energy, operational and financial transactions between any networked entities (equipment, organizations, buildings, grid, etc.). Initially, in FY13, the concept demonstrated transactions between packaged rooftop air conditioners and heat pump units (RTUs) and the electric grid using applications or "agents" that reside on the platform, on the equipment, on a local building controller or in the Cloud. The transactional network project is a multi-lab effort with Oakridge National Laboratory (ORNL) and Lawrence Berkeley National Laboratory (LBNL) also contributing to the effort. PNNL coordinated the project and also was responsible for the development of the transactional network (TN) platform and three different applications associated with RTUs. This document describes two applications or "agents" in details, and also summarizes the platform. The TN platform details are described in another companion document.

  12. Applications of nuclear physics.

    PubMed

    Hayes, A C

    2017-02-01

    Today the applications of nuclear physics span a very broad range of topics and fields. This review discusses a number of aspects of these applications, including selected topics and concepts in nuclear reactor physics, nuclear fusion, nuclear non-proliferation, nuclear-geophysics, and nuclear medicine. The review begins with a historic summary of the early years in applied nuclear physics, with an emphasis on the huge developments that took place around the time of World War II, and that underlie the physics involved in designs of nuclear explosions, controlled nuclear energy, and nuclear fusion. The review then moves to focus on modern applications of these concepts, including the basic concepts and diagnostics developed for the forensics of nuclear explosions, the nuclear diagnostics at the National Ignition Facility, nuclear reactor safeguards, and the detection of nuclear material production and trafficking. The review also summarizes recent developments in nuclear geophysics and nuclear medicine. The nuclear geophysics areas discussed include geo-chronology, nuclear logging for industry, the Oklo reactor, and geo-neutrinos. The section on nuclear medicine summarizes the critical advances in nuclear imaging, including PET and SPECT imaging, targeted radionuclide therapy, and the nuclear physics of medical isotope production. Each subfield discussed requires a review article unto itself, which is not the intention of the current review; rather, the current review is intended for readers who wish to get a broad understanding of applied nuclear physics.

  13. Fuel cell market applications

    SciTech Connect

    Williams, M.C.

    1995-12-31

    This is a review of the US (and international) fuel cell development for the stationary power generation market. Besides DOE, GRI, and EPRI sponsorship, the US fuel cell program has over 40% cost-sharing from the private sector. Support is provided by user groups with over 75 utility and other end-user members. Objectives are to develop and demonstrate cost-effective fuel cell power generation which can initially be commercialized into various market applications using natural gas fuel by the year 2000. Types of fuel cells being developed include PAFC (phosphoric acid), MCFC (molten carbonate), and SOFC (solid oxide); status of each is reported. Potential international applications are reviewed also. Fuel cells are viewed as a force in dispersed power generation, distributed power, cogeneration, and deregulated industry. Specific fuel cell attributes are discussed: Fuel cells promise to be one of the most reliable power sources; they are now being used in critical uninterruptible power systems. They need hydrogen which can be generated internally from natural gas, coal gas, methanol landfill gas, or other fuels containing hydrocarbons. Finally, fuel cell development and market applications in Japan are reviewed briefly.

  14. Load Balancing Scientific Applications

    SciTech Connect

    Pearce, Olga Tkachyshyn

    2014-12-01

    The largest supercomputers have millions of independent processors, and concurrency levels are rapidly increasing. For ideal efficiency, developers of the simulations that run on these machines must ensure that computational work is evenly balanced among processors. Assigning work evenly is challenging because many large modern parallel codes simulate behavior of physical systems that evolve over time, and their workloads change over time. Furthermore, the cost of imbalanced load increases with scale because most large-scale scientific simulations today use a Single Program Multiple Data (SPMD) parallel programming model, and an increasing number of processors will wait for the slowest one at the synchronization points. To address load imbalance, many large-scale parallel applications use dynamic load balance algorithms to redistribute work evenly. The research objective of this dissertation is to develop methods to decide when and how to load balance the application, and to balance it effectively and affordably. We measure and evaluate the computational load of the application, and develop strategies to decide when and how to correct the imbalance. Depending on the simulation, a fast, local load balance algorithm may be suitable, or a more sophisticated and expensive algorithm may be required. We developed a model for comparison of load balance algorithms for a specific state of the simulation that enables the selection of a balancing algorithm that will minimize overall runtime.

  15. Applications of nuclear physics

    NASA Astrophysics Data System (ADS)

    Hayes, A. C.

    2017-02-01

    Today the applications of nuclear physics span a very broad range of topics and fields. This review discusses a number of aspects of these applications, including selected topics and concepts in nuclear reactor physics, nuclear fusion, nuclear non-proliferation, nuclear-geophysics, and nuclear medicine. The review begins with a historic summary of the early years in applied nuclear physics, with an emphasis on the huge developments that took place around the time of World War II, and that underlie the physics involved in designs of nuclear explosions, controlled nuclear energy, and nuclear fusion. The review then moves to focus on modern applications of these concepts, including the basic concepts and diagnostics developed for the forensics of nuclear explosions, the nuclear diagnostics at the National Ignition Facility, nuclear reactor safeguards, and the detection of nuclear material production and trafficking. The review also summarizes recent developments in nuclear geophysics and nuclear medicine. The nuclear geophysics areas discussed include geo-chronology, nuclear logging for industry, the Oklo reactor, and geo-neutrinos. The section on nuclear medicine summarizes the critical advances in nuclear imaging, including PET and SPECT imaging, targeted radionuclide therapy, and the nuclear physics of medical isotope production. Each subfield discussed requires a review article unto itself, which is not the intention of the current review; rather, the current review is intended for readers who wish to get a broad understanding of applied nuclear physics.

  16. Commercial applications for COIL

    NASA Astrophysics Data System (ADS)

    Solomon, Wayne C.; Carroll, David L.; King, D. M.; Fockler, L. A.; Stromberg, D. S.; Sexauer, M.; Milmoe, A.; Sentman, Lee H.

    2000-01-01

    The chemical oxygen-iodine laser (COIL) is a high power, fiber deliverable tool, which can be used for a number of different industrial applications. COIL is of particular interest because of its short fiber deliverable wavelength, high scaleable continuous wave power, and excellent material interaction properties. In past research the University of Illinois at Urbana-Champaign identified and decommissioning and decontamination (DD) of nuclear facilities as a primary focus for COIL technology. DD will be a major challenge in the coming decades. The use of a robotically driven fiber delivered cutting/ablation tool in contaminated areas promises to lower risks to workers for the DD mission. Further, the high cutting speed of COIL will significantly reduce the time required to cut contaminated equipment, reducing costs. The high power of COIL will permit the dismantling of thick stacks of piping and equipment as well as reactor vessels. COIL is very promising for the removal of material from contaminated surfaces, perhaps to depths thicker than an inch. Laser cutting and ablation minimizes dust and fumes, which reduces the required number of high efficiency particulate accumulator filters, thus reducing costly waste disposal. Other potential industrial applications for COIL are shipbuilding, automotive manufacturing, heavy machinery manufacturing, tasks requiring underwater cutting or welding, and there appear to be very promising applications for high powers lasers in the oil industry.

  17. FPA Depot - Web Application

    NASA Technical Reports Server (NTRS)

    Avila, Edwin M. Martinez; Muniz, Ricardo; Szafran, Jamie; Dalton, Adam

    2011-01-01

    Lines of code (LOC) analysis is one of the methods used to measure programmer productivity and estimate schedules of programming projects. The Launch Control System (LCS) had previously used this method to estimate the amount of work and to plan development efforts. The disadvantage of using LOC as a measure of effort is that one can only measure 30% to 35% of the total effort of software projects involves coding [8]. In the application, instead of using the LOC we are using function point for a better estimation of hours in each software to develop. Because of these disadvantages, Jamie Szafran of the System Software Branch of Control And Data Systems (NE-C3) at Kennedy Space Canter developed a web application called Function Point Analysis (FPA) Depot. The objective of this web application is that the LCS software architecture team can use the data to more accurately estimate the effort required to implement customer requirements. This paper describes the evolution of the domain model used for function point analysis as project managers continually strive to generate more accurate estimates.

  18. IMS applications analysis

    SciTech Connect

    RODACY,PHILIP J.; REBER,STEPHEN D.; SIMONSON,ROBERT J.; HANCE,BRADLEY G.

    2000-03-01

    This report examines the market potential of a miniature, hand-held Ion Mobility Spectrometer. Military and civilian markets are discussed, as well as applications in a variety of diverse fields. The strengths and weaknesses of competing technologies are discussed. An extensive Ion Mobility Spectrometry (IMS) bibliography is included. The conclusions drawn from this study are: (1) There are a number of competing technologies that are capable of detecting explosives, drugs, biological, or chemical agents. The IMS system currently represents the best available compromise regarding sensitivity, specificity, and portability. (2) The military market is not as large as the commercial market, but the military services are more likely to invest R and D funds in the system. (3) Military applications should be addressed before commercial applications are addressed. (4) There is potentially a large commercial market for rugged, hand-held Ion Mobility Spectrometer systems. Commercial users typically do not invest R and D funds in this type of equipment rather, they wait for off-the-shelf availability.

  19. Panoramic lens applications revisited

    NASA Astrophysics Data System (ADS)

    Thibault, Simon

    2008-04-01

    During the last few years, innovative optical design strategies to generate and control image mapping have been successful in producing high-resolution digital imagers and projectors. This new generation of panoramic lenses includes catadioptric panoramic lenses, panoramic annular lenses, visible/IR fisheye lenses, anamorphic wide-angle attachments, and visible/IR panomorph lenses. Given that a wide-angle lens images a large field of view on a limited number of pixels, a systematic pixel-to-angle mapping will help the efficient use of each pixel in the field of view. In this paper, we present several modern applications of these modern types of hemispheric lenses. Recently, surveillance and security applications have been proposed and published in Security and Defence symposium. However, modern hemispheric lens can be used in many other fields. A panoramic imaging sensor contributes most to the perception of the world. Panoramic lenses are now ready to be deployed in many optical solutions. Covered applications include, but are not limited to medical imaging (endoscope, rigiscope, fiberscope...), remote sensing (pipe inspection, crime scene investigation, archeology...), multimedia (hemispheric projector, panoramic image...). Modern panoramic technologies allow simple and efficient digital image processing and the use of standard image analysis features (motion estimation, segmentation, object tracking, pattern recognition) in the complete 360° hemispheric area.

  20. [The applicability of results].

    PubMed

    Marín-León, I

    2015-11-01

    The ultimate aim of the critical reading of medical literature is to use the scientific advances in clinical practice or for innovation. This requires an evaluation of the applicability of the results of the studies that have been published, which begins with a clear understanding of these results. When the studies do not provide sufficient guarantees of rigor in design and analysis, the conditions necessary for the applicability of the results are not met; however, the fact that the results are reliable is not enough to make it worth trying to use their conclusions. This article explains how carrying out studies in experimental or artificial conditions often moves them away from the real conditions in which they claim to apply their conclusions. To evaluate this applicability, the article proposes evaluating a set of items that will enable the reader to determine the likelihood that the benefits and risks reported in the studies will yield the least uncertainty in the clinical arena where they aim to be applied.

  1. LAVA Applications to Open Rotors

    NASA Technical Reports Server (NTRS)

    Kiris, Cetin C.; Housman, Jeff; Barad, Mike; Brehm, Christoph

    2015-01-01

    Outline: LAVA (Launch Ascent Vehicle Aerodynamics); Introduction; Acoustics Related Applications; LAVA Applications to Open Rotor; Structured Overset Grids; Cartesian Grid with Immersed Boundary; High Speed Case; High Speed Case with Plate Low Speed Case.

  2. Applications of lobster eye optics

    NASA Astrophysics Data System (ADS)

    Hudec, R.; Pina, L.; Inneman, A.; Tichy, V.

    2015-05-01

    Applications of wide field Lobster Eye X ray telescopes are presented and discussed. The wide field X ray optics was originally proposed for use in X-ray astronomy, but there are numerous other application areas as well.

  3. Sample Cancer Epidemiology Grant Applications

    Cancer.gov

    The National Cancer Institute frequently receives questions from investigators for examples of successfully funded grant applications. Several investigators agreed to let the Epidemiology and Genomics Research Program post excerpts of their grant applications online.

  4. Laser Ablation for Medical Applications

    NASA Astrophysics Data System (ADS)

    Hayashi, Ken-Ichi

    Medical applications of laser are measurement, laser surgery, in-situ monitoring, and processing of medical devices. In this paper, author briefly reviews the trends of medical applications, describes some new applications, and then discuss about the future trends and problems of medical applications. At present, the domestic market of laser equipment for medical applications is nearly 1/10 of that for industrial applications, which has registered significant growth continuously. Laser surgery as a minimum invasive surgery under arthroscope is expected to decrease the pain of patients. Precise processing such as cutting and welding is suitable for manufacturing medical devices. Pulsed laser deposition has been successfully applied to the thin film coating. The corneal refractive surgery by ArF excimer laser has been widely accepted for its highly safe operation. Laser ablation for retinal implant in the visual prosthesis is one of the promising applications of laser ablation in medicine. New applications with femtosecond laser are expected in the near future.

  5. Capacitor Technologies, Applications and Reliability

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Various aspects of capacitor technologies and applications are discussed. Major emphasis is placed on: the causes of failures; accelerated testing; screening tests; destructive physical analysis; applications techniques; and improvements in capacitor capabilities.

  6. Application Kit for Federal Assistance

    EPA Pesticide Factsheets

    The Federal Grant & Cooperative Agreement Act of 1977 requires Federal agencies to use a contract to acquire property or services that directly benefit the Federal government.This letter to the applicant explains the Application Kit for Federal Assistance.

  7. Applicant Analysis: 2001 Entering Class.

    ERIC Educational Resources Information Center

    Weaver, Richard G.; Haden, N. Karl; Ramanna, Satyan; Valachovic, Richard W.

    2003-01-01

    Presents findings of the annual analysis of dental school applicant numbers and characteristics conducted by the American Dental Education Association. There were 7,412 applicants to dental schools in 2001, and 57.6% were enrolled in 2001. Provides other data about applicants and admissions. (SLD)

  8. Birthdates of Medical School Applicants

    ERIC Educational Resources Information Center

    Abel, Ernest L; Sokol, Robert J.; Kruger, Michael L.; Yargeau, Dawn

    2008-01-01

    We determined if the "relative age" effect, wherein older students in an age cohort in early grades do better academically, extends to birthdates of applicants to medical schools, and if birthdates are related to the success of their applications. We examined birthdays of applicants from Michigan to Wayne State University's School of…

  9. Liquid lubrication for space applications

    NASA Technical Reports Server (NTRS)

    Fusaro, Robert L.; Khonsari, Michael M.

    1993-01-01

    Reviewed here is the state of the art of liquid lubrication for space applications. The areas discussed are types of liquid lubrication mechanisms, space environmental effects on lubrication, classification of lubricants, liquid lubricant additives, grease lubrication, mechanism materials, bearing anomalies and failures, lubricant supply techniques, and application types and lubricant needs for those applications.

  10. Liquid lubrication for space applications

    NASA Technical Reports Server (NTRS)

    Fusaro, Robert L.; Khonsari, Michael M.

    1992-01-01

    Reviewed here is the state of the art of liquid lubrication for space applications. The areas discussed are types of liquid lubrication mechanisms, space environmental effects on lubrication, classification of lubricants, liquid lubricant additives, grease lubrication, mechanism materials, bearing anomalies and failures, lubricant supply techniques, and application types and lubricant needs for those applications.

  11. Systems Applications in Higher Education.

    ERIC Educational Resources Information Center

    Schure, Alexander

    This paper discusses the application of computers for higher education and describes a philosophy and initial application of an accountability system that can aid in coping with the problems of occupationally related schools. Discussed are: (1) the role of computers in systems application; (2) the need for systems related information: the…

  12. Technological Applications in Science Assessment.

    ERIC Educational Resources Information Center

    Helgeson, Stanley L.; Kumar, David D.

    Educational technology has been a focus of development and research in science teaching and learning. This document reviews research dealing with computer and hypermedia applications to assessment in science education. The paper reports the findings first for computer applications for assessment and then for hypermedia applications in assessment.…

  13. Radar applications overview

    NASA Astrophysics Data System (ADS)

    Greenspan, Marshall

    1996-06-01

    During the fifty years since its initial development as a means of providing early warning of airborne attacks against allied countries during World War II, radar systems have developed to the point of being highly mobile and versatile systems capable of supporting a wide variety of remote sensing applications. Instead of being tied to stationary land-based sites, radar systems have found their way into highly mobile land vehicles as well as into aircraft, missiles, and ships of all sizes. Of all these applications, however, the most exciting revolution has occurred in the airborne platform arena where advanced technology radars can be found in all shapes and sizes...ranging from the large AWACS and Joint STARS long range surveillance and targeting systems to small millimeter wave multi-spectral sensors on smart weapons that can detect and identify their targets through the use of highly sophisticated digital signal processing hardware and software. This paper presents an overview of these radar applications with the emphasis on modern airborne sensors that span the RF spectrum. It will identify and describe the factors that influence the parameters of low frequency and ultra wide band radars designed to penetrate ground and dense foliage environments and locate within them buried mines, enemy armor, and other concealed or camouflaged weapons of war. It will similarly examine the factors that lead to the development of airborne radar systems that support long range extended endurance airborne surveillance platforms designed to detect and precision-located both small high speed airborne threats as well as highly mobile time critical moving and stationary surface vehicles. The mission needs and associated radar design impacts will be contrasted with those of radar systems designed for high maneuverability rapid acquisition tactical strike warfare platforms, and shorter range cued air-to-surface weapons with integral smart radar sensors.

  14. Factsheets Web Application

    SciTech Connect

    VIGIL,FRANK; REEDER,ROXANA G.

    2000-10-30

    The Factsheets web application was conceived out of the requirement to create, update, publish, and maintain a web site with dynamic research and development (R and D) content. Before creating the site, a requirements discovery process was done in order to accurately capture the purpose and functionality of the site. One of the high priority requirements for the site would be that no specialized training in web page authoring would be necessary. All functions of uploading, creation, and editing of factsheets needed to be accomplished by entering data directly into web form screens generated by the application. Another important requirement of the site was to allow for access to the factsheet web pages and data via the internal Sandia Restricted Network and Sandia Open Network based on the status of the input data. Important to the owners of the web site would be to allow the published factsheets to be accessible to all personnel within the department whether or not the sheets had completed the formal Review and Approval (R and A) process. Once the factsheets had gone through the formal review and approval process, they could then be published both internally and externally based on their individual publication status. An extended requirement and feature of the site would be to provide a keyword search capability to search through the factsheets. Also, since the site currently resides on both the internal and external networks, it would need to be registered with the Sandia search engines in order to allow access to the content of the site by the search engines. To date, all of the above requirements and features have been created and implemented in the Factsheet web application. These have been accomplished by the use of flat text databases, which are discussed in greater detail later in this paper.

  15. Aerospace materials for nonaerospace applications

    NASA Technical Reports Server (NTRS)

    Johnston, R. L.; Dawn, F. S.

    1974-01-01

    Many of the flame-resistant nonmetallic materials that were developed for the Apollo and Skylab programs are discussed for commercial and military applications. Interchanges of information are taking place with the government agencies, industries, and educational institutions, which are interested in applications of fire-safe nonmetallic materials. These materials are particularly applicable to the design of aircraft, mass transit interiors, residential and public building constructions, nursing homes and hospitals, and to other fields of fire safety applications. Figures 22, 23 and 24 show the potential nonaerospace applications of flame-resistant aerospace materials are shown.

  16. Direct application of geothermal energy

    SciTech Connect

    Reistad, G.M.

    1980-01-01

    An overall treatment of direct geothermal applications is presented with an emphasis on the above-ground engineering. The types of geothermal resources and their general extent in the US are described. The potential market that may be served with geothermal energy is considered briefly. The evaluation considerations, special design aspects, and application approaches for geothermal energy use in each of the applications are considered. The present applications in the US are summarized and a bibliography of recent studies and applications is provided. (MHR)

  17. Space applications instrumentation systems

    NASA Technical Reports Server (NTRS)

    Minzner, R. A.; Oberholtzer, J. D.

    1972-01-01

    A compendium of resumes of 158 instrument systems or experiments, of particular interest to space applications, is presented. Each resume exists in a standardized format, permitting entries for 26 administrative items and 39 scientific or engineering items. The resumes are organized into forty groups determined by the forty spacecraft with which the instruments are associated. The resumes are followed by six different cross indexes, each organized alphabetically according to one of the following catagories: instrument name, acronym, name of principal investigator, name of organization employing the principal investigator, assigned experiment number, and spacecraft name. The resumes are associated with a computerized instrument resume search and retrieval system.

  18. Programmable Logic Application Notes

    NASA Technical Reports Server (NTRS)

    Katz, Richard

    1999-01-01

    This column will be provided each quarter as a source for reliability, radiation results, NASA capabilities, and other information on programmable logic devices and related applications. This quarter the focus is on some experimental data on low voltage drop out regulators to support mixed 5 and 3.3 volt systems. A discussion of the Small Explorer WIRE spacecraft will also be given. Lastly, we show take a first look at robust state machines in Hardware Description Languages (VHDL) and their use in critical systems. If you have information that you would like to submit or an area you would like discussed or researched, please give me a call or e-mail.

  19. Introduction to Medical Applications

    NASA Astrophysics Data System (ADS)

    Welch, Ashley J.; van Gemert, Martin J. C.

    The first two parts of this book describe various theories associated with light propagation in tissue and the resulting response. If coherence or polarization information is not needed, we assume that the transport equation governs the optical interaction of light with tissue and the heat conduction equation provides the basis for estimating the thermal response of tissue to laser radiation. In part III of this book, the theory for optical and thermal interactions of laser light with tissue are used to analyze medical applications. In particular, the concepts of parts I and II

  20. NASA RFID Applications

    NASA Technical Reports Server (NTRS)

    Fink, Patrick, Ph.D.; Kennedy, Timothy, Ph.D; Powers, Anne; Haridi, Yasser; Chu, Andrew; Lin, Greg; Yim, Hester; Byerly, Kent, Ph.D.; Barton, Richard, Ph.D.; Khayat, Michael, Ph.D.; Studor, George; Brocato, Robert; Ngo, Phong; Arndt, G. D., Ph.D.; Gross, Julia; Phan, Chau; Ni, David, Ph.D.; Dusl, John; Dekome, Kent

    2007-01-01

    This viewgraph document reviews some potential uses for Radio Frequency Identification in space missions. One of these is inventory management in space, including the methods used in Apollo, the Space Shuttle, and Space Station. The potential RFID uses in a remote human outpost are reviewed. The use of Ultra-Wideband RFID for tracking are examined such as that used in Sapphire DART The advantages of RFID in passive, wireless sensors in NASA applications are shown such as: Micrometeoroid impact detection and Sensor measurements in environmental facilities The potential for E-textiles for wireless and RFID are also examined.

  1. Microdosimetry: Principles and applications

    PubMed Central

    Santa Cruz, Gustavo A.

    2016-01-01

    Aim to present the most important aspects of Microdosimetry, a research field in radiation biophysics. Background microdosimetry is the branch of radiation biophysics that systematically studies the spatial, temporal and spectral aspects of the stochastic nature of the energy deposition processes in microscopic structures. Materials and Methods we briefly review its history, the people, the formalism and the theories and devices that allowed researchers to begin to understand the true nature of radiation action on living matter. Results and Conclusions we outline some of its applications, especially to Boron Neutron Capture Therapy, attempting to explain the biological effectiveness of the boron thermal neutron capture reaction. PMID:26933397

  2. Antenna applications of superconductors

    NASA Astrophysics Data System (ADS)

    Hansen, R. C.

    1991-09-01

    The applicability of superconductors to antennas is examined. Potential implementations that are examined are superdirective arrays; electrically small antennas; tuning and matching of these two; high-gain millimeter-wavelength arrays; and kinetic inductance slow wave structures for array phasers and traveling wave array feeds. It is thought that superdirective arrays and small antennas will not benefit directly, but their tuning/matching networks will undergo major improvements. Miniaturization of antennas will not be aided, but much higher gain millimeter-wave arrays will be realizable. Kinetic inductance slow-wave lines appear advantageous for improved array phasers and time delay, as well as for traveling-wave array feeds.

  3. AGU membership applications

    NASA Astrophysics Data System (ADS)

    Applications for membership have been received from the following individuals. The letter after the name denotes the proposed primary section affiliation.Henry D. I. Abarbanel (O), Julia C. Allen (H), Gwendolyn L. Anson (GP), Andrew Bakun (O), C. A. Bengtson (T), Patricia A. Berge (S), Peter R. Betzer (O), Pierre Boivin (V), Michael V. Capobianco (P), Martin C. Chapman (S), Chu-Yung Chen (V), Timothy J. Clarke (S), Steven C. Constable (GP), Michele Dermer (H), G. M. Dow (T), Carl E. Draper (G), Dean A. Dunn (O), I. B. Everingham (S).

  4. Ultracapacitors for automotive applications

    NASA Astrophysics Data System (ADS)

    Ashtiani, Cyrus; Wright, Randy; Hunt, Gary

    In response to a growing consensus in the auto industry that ultracapacitors can potentially play a key role in the modern vehicle power distribution network, a task force was created at the United States Advanced Battery Consortium (USABC) to tackle issues facing the fledging industry. The task force embarked on first developing and establishing standards for performance and abuse tolerance of ultracapacitors in collaboration with the U.S. Department of Energy and National Labs. Subsequently, potential applications in the automotive industry were identified and a consensus requirement specification was drawn as a development guide for the industry.

  5. Widening ERTS applications

    NASA Technical Reports Server (NTRS)

    Mercanti, E. P.

    1974-01-01

    In less than two years of operation ERTS-1 is shown to have successfully completed its experimental mission and to be delivering an ever-increasing roster of benefits. The widening ERTS applications reviewed include air quality and weather modification, aid to oil exploration, ore-deposit exploration, short-lived event observation, flood area assessment and flood-plain mapping, land and water quality assessment, soil association mapping, crop production measurements, wildlife resources, drought and desertification studies, ground-water exploration, watershed surveys, snow and ice monitoring, surface water mapping, and iceberg surveys. Future projects and developments are also briefly reviewed.

  6. Industrial application experiment series

    NASA Technical Reports Server (NTRS)

    Bluhm, S. A.

    1981-01-01

    Two procurements within the Industrial Application Experiment Series of the Thermal Power Systems Project are discussed. The first procurement, initiated in April 1980, resulted in an award to the Applied Concepts Corporation for the Capital Concrete Experiment: two Fresnel concentrating collectors will be evaluated in single-unit installations at the Jet Propulsion Laboratory Parabolic Dish Test Site and at Capitol Concrete Products, Topeka, Kansas. The second procurement, initiated in March 1981, is titled, "Thermal System Engineering Experiment B." The objective of the procurement is the rapid deployment of developed parabolic dish collectors.

  7. Electromagnetic levitation applications

    SciTech Connect

    Bayazitoglu, Y.

    1996-11-01

    At high temperatures, most materials react with the walls of their containers. This inevitably leads to material contamination and property degradation. Therefore, it becomes difficult to process materials to the required degree of purity and/or measure their properties at high temperatures. Levitation melting has been used on earth and microgravity since to circumvent this problem. In this paper, first a broad survey of the work done in electromagnetic levitation since its invention is given. Then the heat generation due to an alternating magnetic field is studied. Finally, the application of levitation melting in the determination of thermal diffusivity, emissivity, surface tension and viscosity of liquid metals is presented.

  8. Composite prepreg application device

    NASA Technical Reports Server (NTRS)

    Sandusky, Donald A. (Inventor); Marchello, Joseph M. (Inventor)

    1996-01-01

    A heated shoe and cooled pressure roller assembly for composite prepreg application is provided. The shoe assembly includes a heated forward contact surface having a curved pressure surface. The following cooled roller provides a continuous pressure to the thermoplastic while reducing the temperature to approximately 5.degree. C. below glass transition temperature. Electric heating coils inside the forward portion of the shoe heat a thermoplastic workpiece to approximately 100.degree. C. above the glass transition. Immediately following the heated contact surface, a cooled roller cools the work. The end sharpened shape of the heated shoe trailing edge tends to prevent slag buildup and maintain a uniform, relaxed stress fabrication.

  9. Thermoplastics for prosthetic applications.

    PubMed

    Lawrence, R B; Davies, R M

    1981-10-01

    The rapid and accurate thermoforming of plastics for prosthetic applications has been the subject of considerable research and development by the Bioengineering Centre. This paper outlines the progress in the general concepts that have been effected to date. The original below knee (B/K) socket vacuum forming technique has been extended to above knee (A/K) and supracondylar cases, and there have been developments in rotational casting technology. The work is necessarily based on a sound understanding of the properties of the materials concerned and of the associated manufacturing processes. The contribution of the Bioengineering Centre is outlined together with summaries of collaborative work carried out with other organizations.

  10. Laser applications in phlebology

    NASA Astrophysics Data System (ADS)

    Longo, Leonardo; Mancini, S.; Postiglione, Marco; Postiglione, M. G.

    2001-06-01

    PURPOSE: review of laser used in phlebology METHOD: critical analysis of scientific data taken from the literature and based on 25 years personal experience. RESULTS: we have three groups of laser applications in phlebology: for the diagnosis, as physical therapy and as surgical therapy. DISCUSSION AND CONCLUSION: the laser-doppler studies the microcirculations, the no-surgical therapy shown positive results in the treatment of venous ulcers and for the wound healing. It could be indicate also as antiphlogistic and anti-edema therapy, in superficial thrombophlebitis. The surgical laser is useful for the surgical cleaning of ulcers, for haemorroids, angiomas and telangiectases.

  11. Lubricants in conveyor applications

    SciTech Connect

    Paton, C.G.; Bland, S.B.; Melley, R.E.

    1995-01-01

    This paper looks at four critical lubricants used in the conveyor systems of the northern Albertan oil sand facility. The requirements for the lubricants used in the electric motors and gear boxes of the drive systems, the pulley bearings and the idler bearings are discussed in terms of the application and the environment. A number of developments that have occurred in recent years are presented. Data from the field and from custom designed testing in the laboratory are used to support the role of simulation testing in problem solving in this area of technology. 9 refs., 21 figs.

  12. Digital communications: Microwave applications

    NASA Astrophysics Data System (ADS)

    Feher, K.

    Transmission concepts and techniques of digital systems are presented; and practical state-of-the-art implementation of digital communications systems by line-of-sight microwaves is described. Particular consideration is given to statistical methods in digital transmission systems analysis, digital modulation methods, microwave amplifiers, system gain, m-ary and QAM microwave systems, correlative techniques and applications to digital radio systems, hybrid systems, digital microwave systems design, diversity and protection switching techniques, measurement techniques, and research and development trends and unsolved problems.

  13. Applications of Groundwater Helium

    USGS Publications Warehouse

    Kulongoski, Justin T.; Hilton, David R.

    2011-01-01

    Helium abundance and isotope variations have widespread application in groundwater-related studies. This stems from the inert nature of this noble gas and the fact that its two isotopes ? helium-3 and helium-4 ? have distinct origins and vary widely in different terrestrial reservoirs. These attributes allow He concentrations and 3He/4He isotope ratios to be used to recognize and quantify the influence of a number of potential contributors to the total He budget of a groundwater sample. These are atmospheric components, such as air-equilibrated and air-entrained He, as well as terrigenic components, including in situ (aquifer) He, deep crustal and/or mantle He and tritiogenic 3He. Each of these components can be exploited to reveal information on a number of topics, from groundwater chronology, through degassing of the Earth?s crust to the role of faults in the transfer of mantle-derived volatiles to the surface. In this review, we present a guide to how groundwater He is collected from aquifer systems and quantitatively measured in the laboratory. We then illustrate the approach of resolving the measured He characteristics into its component structures using assumptions of endmember compositions. This is followed by a discussion of the application of groundwater He to the types of topics mentioned above using case studies from aquifers in California and Australia. Finally, we present possible future research directions involving dissolved He in groundwater.

  14. Plasma core reactor applications

    NASA Technical Reports Server (NTRS)

    Latham, T. S.; Rodgers, R. J.

    1976-01-01

    Analytical and experimental investigations were conducted to demonstrate the feasibility of fissioning uranium plasma core reactors and to characterize space and terrestrial applications for such reactors. Uranium hexafluoride fuel is injected into core cavities and confined away from the surface by argon buffer gas injected tangentially from the peripheral walls. Radiant heat transfer calculations were performed for a six-cavity reactor configuration. Axial working fluid channels are located along a fraction of each cavity peripheral wall. Results of calculations for outward-directed radiant energy fluxes corresponding to radiating temperatures of 2000 to 5000 K indicate total operating pressures from 80 to 650 atm, centerline temperatures from 6900 to 30,000 K, and total radiated powers from 25 to 2500 MW, respectively. Applications are described for this type of reactor such as (1) high-thrust, high specific impulse space propulsion, (2) highly efficient systems for generation of electricity, and (3) hydrogen or synthetic fuel production systems using the intense radiant energy fluxes.

  15. Superstatistics: Theory and Applications

    NASA Astrophysics Data System (ADS)

    Beck, C.

    2015-12-01

    Many driven nonequilibrium systems are described by a superposition of several dynamics on various time scales. If time scales are clearly separated then the formalism of superstatistics can be applied, leading effectively to a more general statistical mechanics relevant for complex systems. In these types of systems there is often dynamical behavior that is characterized by spatio-temporal fluctuations of an intensive parameter β. This parameter may be for example the inverse temperature, or an effective friction constant, or the amplitude of Gaussian white noise, or the energy dissipation in turbulent flows, or simply a local variance parameter extracted from a measured signal. A nonhomogenoeus spatially extended system with fluctuations in β on a large time scale, larger than the local relaxation time, leads to a superstatistical description, by averaging local Boltzmann factors using a suitable weight function f(β). Kappa distributions in space plasma physics are one example which naturally follows out of this formalism, but there are many applications in other areas as well. In this talk I will sketch the basic theory underlying the superstatistical approach and then describe a couple of recent applications.

  16. Environmental Applications of Nanotechnology

    NASA Astrophysics Data System (ADS)

    Keller, Arturo A.

    2014-07-01

    Engineered nanomaterials (ENMs) are currently used in many applications including agriculture (Gruère, 2012; Khot et al. 2012; Lopez-Moreno et al. 2010; Peralta-Videa et al. 2011; Zhao et al. 2012), aerogels (Bigall et al. 2009), aerospace (Baur and Silverman, 2007), automotive (Coelho et al. 2012; Presting and König, 2003; Salonitis et al. 2010), catalysts (Zhou et al. 2011), coatings, paints and pigments (Dhoke et al. 2009; Gopalakrishnan et al. 2011; Khanna, 2008), composites (Borchardt, 2003; Khanna and Bakshi, 2009; Petrov and Georgiev, 2012; Sahoo et al. 2010), construction (Lee et al. 2010), cosmetics (Musee, 2011; Sabitha et al. 2012; Singh and Nanda, 2012), electronics and optics (Alda et al. 2005; Avasthi et al. 2007; Song et al. 2012; Subramanian and Takhee, 2012), energy (Serrano et al. 2009), environmental remediation (Dionysiou 2004; Khin et al. 2012), filtration and purification (Dhakras, 2011; Savage and Diallo, 2005), food products (Blasco and Picó, 2011; Weiss et al. 2006), medical (Boisseau and Loubaton, 2011; Farokhzad and Langer, 2006), packaging (Silvestre et al. 2011), paper and board (Kharisov and Kharissova, 2010), plastics, security (Marín and Merkoçi, 2012), sensors (Ding et al. 2010; Duncan et al. 2012; Su et al. 2012; Tan et al. 2012), and textiles (Qian and Hinestroza, 2004; Wong et al. 2006), and research is underway on many new applications...

  17. Applications of nuclear physics

    DOE PAGES

    Hayes-Sterbenz, Anna Catherine

    2017-01-10

    Today the applications of nuclear physics span a very broad range of topics and fields. This review discusses a number of aspects of these applications, including selected topics and concepts in nuclear reactor physics, nuclear fusion, nuclear non-proliferation, nuclear-geophysics, and nuclear medicine. The review begins with a historic summary of the early years in applied nuclear physics, with an emphasis on the huge developments that took place around the time of World War II, and that underlie the physics involved in designs of nuclear explosions, controlled nuclear energy, and nuclear fusion. The review then moves to focus on modern applicationsmore » of these concepts, including the basic concepts and diagnostics developed for the forensics of nuclear explosions, the nuclear diagnostics at the National Ignition Facility, nuclear reactor safeguards, and the detection of nuclear material production and trafficking. The review also summarizes recent developments in nuclear geophysics and nuclear medicine. The nuclear geophysics areas discussed include geo-chronology, nuclear logging for industry, the Oklo reactor, and geo-neutrinos. The section on nuclear medicine summarizes the critical advances in nuclear imaging, including PET and SPECT imaging, targeted radionuclide therapy, and the nuclear physics of medical isotope production. Lastly, each subfield discussed requires a review article unto itself, which is not the intention of the current review; rather, the current review is intended for readers who wish to get a broad understanding of applied nuclear physics.« less

  18. Novel oral laser applications

    NASA Astrophysics Data System (ADS)

    Yousif, A.; Strassl, M.; Beer, F.; Verhagen, L.; Wittschier, M.; Wintner, E.

    2007-03-01

    In dental hard tissue ablation, ultra-short laser pulses have proven sufficiently their potential for material ablation with negligible collateral damage providing many advantages. The absence of micro-cracks and the possibility to avoid overheating of the pulp during dental cavity preparation may be among the most important issues, the latter opening up an avenue for potential painless treatment. Beside the evident short interaction time of laser radiation with the irradiated tissue, scanning of the ultra-short pulse trains turned out to be crucial for ablating cavities of required quality and shape. Additionally, long-pulsed laser systems have demonstrated successfully their suitability for decontamination purposes. In this paper, an overview of different indications for laser application in dental therapies in both pulse regimes is presented. A special focus is set on the decontamination of dental implants in periimplantitis therapy. Having employed commercially available long pulse systems for dental applications and ultra-short 330 fs pulses, we present first results for temperature development and corresponding ablation thresholds for dental implants, as in the future more gentle implant cleaning by ultra-short laser pulses could become of interest.

  19. Surety applications in transportation

    SciTech Connect

    Matalucci, R.V.; Miyoshi, D.S.

    1998-01-01

    Infrastructure surety can make a valuable contribution to the transportation engineering industry. The lessons learned at Sandia National Laboratories in developing surety principles and technologies for the nuclear weapons complex and the nuclear power industry hold direct applications to the safety, security, and reliability of the critical infrastructure. This presentation introduces the concepts of infrastructure surety, including identification of the normal, abnormal, and malevolent threats to the transportation infrastructure. National problems are identified and examples of failures and successes in response to environmental loads and other structural and systemic vulnerabilities are presented. The infrastructure surety principles developed at Sandia National Laboratories are described. Currently available technologies including (a) three-dimensional computer-assisted drawing packages interactively combined with virtual reality systems, (b) the complex calculational and computational modeling and code-coupling capabilities associated with the new generation of supercomputers, and (c) risk-management methodologies with application to solving the national problems associated with threats to the critical transportation infrastructure are discussed.

  20. Clean Energy Application Center

    SciTech Connect

    Freihaut, Jim

    2013-09-30

    The Mid Atlantic Clean Energy Application Center (MACEAC), managed by The Penn State College of Engineering, serves the six states in the Mid-Atlantic region (Pennsylvania, New Jersey, Delaware, Maryland, Virginia and West Virginia) plus the District of Columbia. The goals of the Mid-Atlantic CEAC are to promote the adoption of Combined Heat and Power (CHP), Waste Heat Recovery (WHR) and District Energy Systems (DES) in the Mid Atlantic area through education and technical support to more than 1,200 regional industry and government representatives in the region. The successful promotion of these technologies by the MACEAC was accomplished through the following efforts; (1)The MACEAC developed a series of technology transfer networks with State energy and environmental offices, Association of Energy Engineers local chapters, local community development organizations, utilities and, Penn State Department of Architectural Engineering alumni and their firms to effectively educate local practitioners about the energy utilization, environmental and economic advantages of CHP, WHR and DES; (2) Completed assessments of the regional technical and market potential for CHP, WHR and DE technologies application in the context of state specific energy prices, state energy and efficiency portfolio development. The studies were completed for Pennsylvania, New Jersey and Maryland and included a set of incentive adoption probability models used as a to guide during implementation discussions with State energy policy makers; (3) Using the technical and market assessments and adoption incentive models, the Mid Atlantic CEAC developed regional strategic action plans for the promotion of CHP Application technology for Pennsylvania, New Jersey and Maryland; (4) The CHP market assessment and incentive adoption model information was discussed, on a continuing basis, with relevant state agencies, policy makers and Public Utility Commission organizations resulting in CHP favorable incentive

  1. Web Platform Application

    SciTech Connect

    Paulsworth, Ashley; Kurtz, Jim; Brun de Pontet, Stephanie

    2016-06-15

    Sunvestment Energy Group (previously called Sunvestment Group) was established to create a web application that brings together site hosts, those who will obtain the energy from the solar array, with project developers and funders, including affinity investors. Sunvestment Energy Group (SEG) uses a community-based model that engages with investors who have some affinity with the site host organization. In addition to a financial return, these investors receive non-financial value from their investments and are therefore willing to offer lower cost capital. This enables the site host to enjoy more savings from solar through these less expensive Community Power Purchase Agreements (CPPAs). The purpose of this award was to develop an online platform to bring site hosts and investors together virtually.

  2. Persuasive Mobile Health Applications

    NASA Astrophysics Data System (ADS)

    Garcia Wylie, Carlos; Coulton, Paul

    With many industrialized societies bearing the cost of an increasingly sedentary lifestyle on the health of their populations there is a need to find new ways of encouraging physical activity to promote better health and well being. With the increasing power of mobile phones and the recent emergence of personal heart rate monitors, aimed at dedicated amateur runners, there is now a possibility to develop “Persuasive Mobile Health Applications” to promote well being through the use of real-time physiological data and persuade users to adopt a healthier lifestyle. In this paper we present a novel general health monitoring software for mobile phones called Heart Angel. This software is aimed at helping users monitor, record, as well as improve their fitness level through built-in cardio-respiratory tests, a location tracking application for analyzing heart rate exertion over time and location, and a fun mobile-exergame called Health Defender.

  3. Terahertz technology and applications

    NASA Technical Reports Server (NTRS)

    Siegel, P.

    2002-01-01

    Despite great scientific interest since at least the 1920's, the THz frequency range remains on e of the least tapped regions of the electromagnetic spectrum. Sandwiched between traditional microwave and optical technologies where there is a limited atmospheric propagation path, little commercial emphasis has been placed on THz systems. This has, perhaps fortunately, preserved some unique science and applications for tomorrow's technologies. For over 25 years the sole niche for THz technology has been in the high resolution spectroscopy and remote sensing areas where heterodyne and Fourier transform techniques have allowed astronomers, chemists, Earth, planetary and space scientists to measure, catalog and map thermal emission lines for a wide variety of lightweight molecules. As it turns out, no where else in the electromagnetic spectrum do we receive so much information about these chemical species. In fact, the universe is bathed in THz energy, most of it going unnoticed and undetected.

  4. Laser Applications in Orthodontics

    PubMed Central

    Heidari, Somayeh; Torkan, Sepideh

    2013-01-01

    A laser is a collimated single wavelength of light which delivers a concentrated source of energy. Soon after different types of lasers were invented, investigators began to examine the effects of different wavelengths of laser energy on oral tissues, routine dental procedures and experimental applications. Orthodontists, along with other specialist in different fields of dentistry, can now benefit from several different advantages that lasers provide during the treatment process, from the beginning of the treatment, when separators are placed, to the time of resin residues removal from the tooth surface at the end of orthodontic treatment. This article outlines some of the most common usages of laser beam in orthodontics and also provides a comparison between laser and other conventional method that were the standard of care prior to the advent of laser in this field. PMID:25606324

  5. ICE SLURRY APPLICATIONS

    PubMed Central

    Kauffeld, M.; WANG, M. J.; Goldstein, V.; Kasza, K. E.

    2011-01-01

    The role of secondary refrigerants is expected to grow as the focus on the reduction of greenhouse gas emissions increases. The effectiveness of secondary refrigerants can be improved when phase changing media are introduced in place of single phase media. Operating at temperatures below the freezing point of water, ice slurry facilitates several efficiency improvements such as reductions in pumping energy consumption as well as lowering the required temperature difference in heat exchangers due to the beneficial thermo-physical properties of ice slurry. Research has shown that ice slurry can be engineered to have ideal ice particle characteristics so that it can be easily stored in tanks without agglomeration and then be extractable for pumping at very high ice fraction without plugging. In addition ice slurry can be used in many direct contact food and medical protective cooling applications. This paper provides an overview of the latest developments in ice slurry technology. PMID:21528014

  6. Laser applications in neurosurgery

    NASA Astrophysics Data System (ADS)

    Cerullo, Leonard J.

    1985-09-01

    The "false start" of the laser in neurosurgery should not be misconstrued as a denial of the inherent advantages of precision and gentleness in dealing with neural tissue. Rather, early investigators were frustrated by unrealistic expectations, cumbersome equipment, and a general ignorance of microtechnique. By the early 70s, microneurosurgery was well established, surgical laser equipment for free hand and microlinked application had been developed, and a more realistic view of the limitations of the laser had been established. Consequently, the late 70s really heralded the renaissance of the laser in neurosurgery. Since then, there has been an overwhelming acceptance of the tool in a variety of clinical situations, broadly categorized in five groups. 1)|Perhaps the most generally accepted area is in the removal of extra-axial tumors of the brain and spinal cord. These tumors, benign by histology but treacherous by location, do not present until a significant amount of neurological compensation has already occurred. The application of additional trauma to the neural tissue, whether by further tumor growth or surgical manipulation, frequently results in irreversible damage. Here, the ability of the laser to vaporize tissue, in a fairly hemostatic fashion, without mechanical or thermal damage to sensitive surrounding tissues, is essential. 2)|The ability to incise delicate neural tissue with minimal spread of thermal destruction to adjacent functioning tissue makes the laser the ideal instrument when tumors deep under the surface are encountered in the brain or spinal cord. Thus, the second group of applications is in the transgression of normal neural structures to arrive at deeper pathological tissue. 3)|The third area of benefit for the laser in neurosurgery has been in the performance of neuroablative procedures, calling for deliberate destruction of functioning neural tissue in a controlled fashion. Again, the precision and shape confinement of the destructive

  7. Biomedical applications of collagens.

    PubMed

    Ramshaw, John A M

    2016-05-01

    Collagen-based biomedical materials have developed into important, clinically effective materials used in a range of devices that have gained wide acceptance. These devices come with collagen in various formats, including those based on stabilized natural tissues, those that are based on extracted and purified collagens, and designed composite, biosynthetic materials. Further knowledge on the structure and function of collagens has led to on-going developments and improvements. Among these developments has been the production of recombinant collagen materials that are well defined and are disease free. Most recently, a group of bacterial, non-animal collagens has emerged that may provide an excellent, novel source of collagen for use in biomaterials and other applications. These newer collagens are discussed in detail. They can be modified to direct their function, and they can be fabricated into various formats, including films and sponges, while solutions can also be adapted for use in surface coating technologies.

  8. Applications of magnetic sails

    NASA Astrophysics Data System (ADS)

    Love, S. G.; Andrews, D. G.

    The interplanetary magnetic sail is a low-thrust propulsion device that derives its motive power from the interaction of solar wind ions with the magnetic field of a circular current-bearing loop of superconducting cable. The principal advantage of a magnetic sail is that it produces thrust in opposition to the sun's gravity without consuming any propellant whatsoever. The low acceleration of a magnetic sail restricts its applicability to missions that do not demand rapid changes in velocity. In many cases, though, that disadvantage is overwhelmed by the desirability of a system that does not have to be refuelled. Missions well suited for magnetic sails include propulsion for a robot asteroid surveyor, orbital correction for structures in unstable libration points, motive power for orbital correction near planets with magnetic fields, and aerobraking in planetary ionospheres.

  9. The Booster Applications Facility

    NASA Astrophysics Data System (ADS)

    Goodwin, David P.

    2001-02-01

    In support of the human exploration program, NASA is providing $33 million to the U.S. Department of Energy to construct a radiation simulator, known as the Booster Applications Facility (BAF). The BAF justification is briefly reviewed (e.g., to reduce the radiation risk uncertainties from its present factor of 4 to 15). The BAF beam specifications are provided, as are discussions of the BAF construction schedule and anticipated operating schedules (e.g., initial operation anticipated for October 1, 2002). A breakdown of the BAF construction costs is included and the operating costs are discussed (e.g., $5 to $6 million per year). The BAF laboratory layout and the various types of DOE support for the BAF are summarized, as are the peer reviews of the project. The characteristic parameters of the Alternating Gradient Synchrotron are also included. .

  10. Nanotechnology Applications for Glaucoma.

    PubMed

    Cetinel, Sibel; Montemagno, Carlo

    2016-01-01

    Glaucoma is the second leading cause of blindness worldwide, and the antiglaucoma treatments currently available suffer from various complications. Nanotechnology-based treatments show a great deal of promise in overcoming these complications and form the basis for next-generation glaucoma treatment strategies, with the help of applications such as controlled release, targeted delivery, increased bioavailability, diffusion limitations, and biocompatibility. Significant progress has been made in nanomedicine in the efficiency of antiglaucoma medications, nanofabrication systems such as microelectromechanical systems that remove the limitations of nanodevices, and tissue regeneration vesicles for developing glaucoma treatments not based on intraocular pressure. With the use of these advanced technologies, the prevention of glaucoma-induced blindness will be possible in the near future. Herein, we reviewed the recent advances in nanotechnology-based treatment strategies for glaucoma.

  11. Applications Outside HEP

    NASA Astrophysics Data System (ADS)

    Le Dû, Patrick

    High energy and particle physics has considerable acquired knowledge, expertise and resources that can, when transferred in a realistic way, significantly impact the practice of medical imaging for diagnosis and therapy. This overview introductory talk "from basic science to the clinical reality" intends to show how successful technology transfer between fundamental research in particle physics and medical imaging can be achieved using some specific examples. Using as input, the recent advance of HEP state of the art techniques and tools in detectors developments such as solid state and gaseous detectors, calorimeters, photodetectors, read-out electronics and simulations, some direct applications in medical and molecular imaging will be presented like Positron Emission Tomography (PET) and particle therapy.

  12. Stimulus Application? Not Me

    SciTech Connect

    Wiley, H. S.

    2009-06-01

    I am afraid the situation with respect to the Challenge Grants will be similar in that only a small fraction of the expected deluge of grants will be funded. NIH has provided a very specific list of over 60 topics and a simple calculation shows that only a couple of grants will be funded per topic. Science magazine quotes the Vice Chancellor for Research at the University of California, Irvine as saying that her campus will be submitting “over 200” Challenge Grants. My discussions with friends from other universities suggest that this is a typical response. Even if this is an overestimate by a factor of 2, this would still translate to many thousands of applications flooding into the NIH, putting the payline well below the 4% that I experienced from the DoD. As was the case with the Army grants, I suspect that if the topics are not addressed exactly, grants will not stand a chance.

  13. Applications of modern ferroelectrics.

    PubMed

    Scott, J F

    2007-02-16

    Long viewed as a topic in classical physics, ferroelectricity can be described by a quantum mechanical ab initio theory. Thin-film nanoscale device structures integrated onto Si chips have made inroads into the semiconductor industry. Recent prototype applications include ultrafast switching, cheap room-temperature magnetic-field detectors, piezoelectric nanotubes for microfluidic systems, electrocaloric coolers for computers, phased-array radar, and three-dimensional trenched capacitors for dynamic random access memories. Terabit-per-square-inch ferroelectric arrays of lead zirconate titanate have been reported on Pt nanowire interconnects and nanorings with 5-nanometer diameters. Finally, electron emission from ferroelectrics yields cheap, high-power microwave devices and miniature x-ray and neutron sources.

  14. Panarchy: theory and application

    USGS Publications Warehouse

    Allen, Craig R.; Angeler, David G.; Garmestani, Ahjond S.; Gunderson, Lance H.; Holling, Crawford S.

    2014-01-01

    The concept of panarchy provides a framework that characterizes complex systems of people and nature as dynamically organized and structured within and across scales of space and time. It has been more than a decade since the introduction of panarchy. Over this period, its invocation in peer-reviewed literature has been steadily increasing, but its use remains primarily descriptive and abstract. Here, we discuss the use of the concept in the literature to date, highlight where the concept may be useful, and discuss limitations to the broader applicability of panarchy theory for research in the ecological and social sciences. Finally, we forward a set of testable hypotheses to evaluate key propositions that follow from panarchy theory.

  15. Topography measurements and applications

    NASA Astrophysics Data System (ADS)

    Song, Junfeng; Vorburger, Theodore

    2006-11-01

    Based on auto- and cross-correlation functions (ACF and CCF), a new surface parameter called profile (or topography) difference, D s, has been developed for quantifying differences between 2D profiles or between 3D topographies with a single number. When D s = 0, the two compared 2D profiles or 3D topographies must be exactly the same (point by point). A 2D and 3D topography measurement system was established at NIST. This system includes data acquisition stations using a stylus instrument and a confocal microscope, and a correlation program using the proposed parameters D s and the cross-correlation function maximum CCF max. Applications in forensic science and surface metrology are described; those include profile signature measurements for 40 NIST Standard Reference Material (SRM) 2460 standard bullets, and comparisons of profile measurements with four different techniques. An approach to optimizing the Gaussian filter long wavelength cutoff, λc, is proposed for topography measurements.

  16. Clinical application of ghrelin.

    PubMed

    Strasser, Florian

    2012-01-01

    Ghrelin as a human natural hormone is involved in fundamental regulatory processes of eating and energy balance. Ghrelin signals the nutrient availability from the gastrointestinal tract to the central nervous system, up-regulates food intake and lowers energy expenditure mainly through hypothalamic mediators acting both centrally and peripherally including the gastrointestinal tract (motility, epithelium), promotes both neuro-endocrine and inflammatory signals to increase skeletal muscle growth and decrease protein breakdown, and increases lipolysis while body fat utilization is reduced. Ghrelin does more to exert its probably sentinel role around "human energy": it influences through mainly extra-hypothalamic actions the hedonic and incentive value of food, mood and anxiety, sleep-wake regulation, learning and memory, and neurogenesis. Recently numerous ghrelin gene-derived peptides were discovered, demonstrating the complexity within the ghrelin/ghrelin receptor axis. For clinical applications, not only the natural ghrelin and its slice variants, but also several modified or artificial molecules acting at ghrelin-associated receptors were and are developed. Current clinical applications are limited to clinical studies, focusing mainly on cachexia in chronic heart failure, COPD, cancer, endstage- renal-disease or cystic fibrosis, but also on frailty in elderly, gastrointestinal motility (e.g., gastroparesis, functional dyspepsia, postoperative ileus), after curative gastrectomy, anorexia nervosa, growth hormone deficient patients, alcohol craving, sleep-wake regulation (e.g. major depression), or sympathetic nervous activity in obesity. The results of completed, preliminary studies support the clinical potential of ghrelin, ghrelin gene-derived peptides, and artificial analogues, suggesting that larger clinical trials are demanded to move ghrelin towards an available and reimbursed pharmaceutical intervention.

  17. [Skeleton extractions and applications].

    SciTech Connect

    Quadros, William Roshan

    2010-05-01

    This paper focuses on the extraction of skeletons of CAD models and its applications in finite element (FE) mesh generation. The term 'skeleton of a CAD model' can be visualized as analogous to the 'skeleton of a human body'. The skeletal representations covered in this paper include medial axis transform (MAT), Voronoi diagram (VD), chordal axis transform (CAT), mid surface, digital skeletons, and disconnected skeletons. In the literature, the properties of a skeleton have been utilized in developing various algorithms for extracting skeletons. Three main approaches include: (1) the bisection method where the skeleton exists at equidistant from at least two points on boundary, (2) the grassfire propagation method in which the skeleton exists where the opposing fronts meet, and (3) the duality method where the skeleton is a dual of the object. In the last decade, the author has applied different skeletal representations in all-quad meshing, hex meshing, mid-surface meshing, mesh size function generation, defeaturing, and decomposition. A brief discussion on the related work from other researchers in the area of tri meshing, tet meshing, and anisotropic meshing is also included. This paper concludes by summarizing the strengths and weaknesses of the skeleton-based approaches in solving various geometry-centered problems in FE mesh generation. The skeletons have proved to be a great shape abstraction tool in analyzing the geometric complexity of CAD models as they are symmetric, simpler (reduced dimension), and provide local thickness information. However, skeletons generally require some cleanup, and stability and sensitivity of the skeletons should be controlled during extraction. Also, selecting a suitable application-specific skeleton and a computationally efficient method of extraction is critical.

  18. USAF solar thermal applications overview

    NASA Technical Reports Server (NTRS)

    Hauger, J. S.; Simpson, J. A.

    1981-01-01

    Process heat applications were compared to solar thermal technologies. The generic process heat applications were analyzed for solar thermal technology utilization, using SERI's PROSYS/ECONOMAT model in an end use matching analysis and a separate analysis was made for solar ponds. Solar technologies appear attractive in a large number of applications. Low temperature applications at sites with high insolation and high fuel costs were found to be most attractive. No one solar thermal technology emerges as a clearly universal or preferred technology, however,, solar ponds offer a potential high payoff in a few, selected applications. It was shown that troughs and flat plate systems are cost effective in a large number of applications.

  19. Parallel programming of industrial applications

    SciTech Connect

    Heroux, M; Koniges, A; Simon, H

    1998-07-21

    In the introductory material, we overview the typical MPP environment for real application computing and the special tools available such as parallel debuggers and performance analyzers. Next, we draw from a series of real applications codes and discuss the specific challenges and problems that are encountered in parallelizing these individual applications. The application areas drawn from include biomedical sciences, materials processing and design, plasma and fluid dynamics, and others. We show how it was possible to get a particular application to run efficiently and what steps were necessary. Finally we end with a summary of the lessons learned from these applications and predictions for the future of industrial parallel computing. This tutorial is based on material from a forthcoming book entitled: "Industrial Strength Parallel Computing" to be published by Morgan Kaufmann Publishers (ISBN l-55860-54).

  20. Deaf mobile application accessibility requirements

    NASA Astrophysics Data System (ADS)

    Nathan, Shelena Soosay; Hussain, Azham; Hashim, Nor Laily

    2016-08-01

    Requirement for deaf mobile applications need to be analysed to ensure the disabilities need are instilled into the mobile applications developed for them. Universal design is understandable to comply every user needs, however specific disability is argued by the authors to have different need and requirements. These differences are among the reasons for these applications being developed to target for a specific group of people, however they are less usable and later abandoned. This study focuses on deriving requirements that are needed by the deaf in their mobile applications that are meant specifically for them. Studies on previous literature was conducted it can be concluded that graphic, text, multimedia and sign language interpreter are among mostly required features to be included in their mobile application to ensure the applications are usable for this community.

  1. 76 FR 35411 - Applications for Trademark Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-17

    ... Trademark Electronic Application System (TEAS) using a regular TEAS application form or a TEAS Plus application form. Applicants that file their applications using the TEAS Plus form pay a reduced filing fee if... through TEAS, and agree to receive communications concerning the application by e-mail. TEAS...

  2. 7 CFR 97.14 - Joint applicants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Joint applicants. 97.14 Section 97.14 Agriculture... PLANT VARIETY AND PROTECTION The Application § 97.14 Joint applicants. (a) Joint owners shall file a joint application by signing as joint applicants. (b) If an application for certificate is made by...

  3. 7 CFR 97.14 - Joint applicants.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Joint applicants. 97.14 Section 97.14 Agriculture... PLANT VARIETY AND PROTECTION The Application § 97.14 Joint applicants. (a) Joint owners shall file a joint application by signing as joint applicants. (b) If an application for certificate is made by...

  4. 7 CFR 97.14 - Joint applicants.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Joint applicants. 97.14 Section 97.14 Agriculture... PLANT VARIETY AND PROTECTION The Application § 97.14 Joint applicants. (a) Joint owners shall file a joint application by signing as joint applicants. (b) If an application for certificate is made by...

  5. 7 CFR 97.14 - Joint applicants.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Joint applicants. 97.14 Section 97.14 Agriculture... PLANT VARIETY AND PROTECTION The Application § 97.14 Joint applicants. (a) Joint owners shall file a joint application by signing as joint applicants. (b) If an application for certificate is made by...

  6. 7 CFR 97.14 - Joint applicants.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Joint applicants. 97.14 Section 97.14 Agriculture... PLANT VARIETY AND PROTECTION The Application § 97.14 Joint applicants. (a) Joint owners shall file a joint application by signing as joint applicants. (b) If an application for certificate is made by...

  7. Dynamic load balancing of applications

    DOEpatents

    Wheat, S.R.

    1997-05-13

    An application-level method for dynamically maintaining global load balance on a parallel computer, particularly on massively parallel MIMD computers is disclosed. Global load balancing is achieved by overlapping neighborhoods of processors, where each neighborhood performs local load balancing. The method supports a large class of finite element and finite difference based applications and provides an automatic element management system to which applications are easily integrated. 13 figs.

  8. Dynamic load balancing of applications

    DOEpatents

    Wheat, Stephen R.

    1997-01-01

    An application-level method for dynamically maintaining global load balance on a parallel computer, particularly on massively parallel MIMD computers. Global load balancing is achieved by overlapping neighborhoods of processors, where each neighborhood performs local load balancing. The method supports a large class of finite element and finite difference based applications and provides an automatic element management system to which applications are easily integrated.

  9. Holographic Cinematography And Its Applications

    NASA Astrophysics Data System (ADS)

    Smigielski, Paul

    1987-09-01

    We describe several applications of cineholography to objects scattering light by reflection: single-exposure cineholograms on 126-mm films at a repetition rate of 25 holograms per second for 3-D movies and for flight simulators applications, double-exposure cineholograms for medical and industrial applications (NDT). Limitations of cineholography are also described. The light source used for cineholograms recording is a frequency-doubled pulse YAG-laser.

  10. Microplasmas: from applications to fundamentals

    NASA Astrophysics Data System (ADS)

    Nguon, Olivier; Huang, Sisi; Gauthier, Mario; Karanassios, Vassili

    2014-05-01

    Microplasmas are receiving increasing attention in the scientific literature and in recent conferences. Yet, few analytical applications of microplasmas for elemental analysis using liquid samples have been described in the literature. To address this, we describe two applications: one involves the determination of Zn in microsamples of the metallo-enzyme Super Oxide Dismutase. The other involves determination of Pd-concentration in microsamples of Pd nanocatalysts. These applications demonstrate the potential of microplasmas and point to the need for future fundamental studies.

  11. Applications and limitations of radiomics.

    PubMed

    Yip, Stephen S F; Aerts, Hugo J W L

    2016-07-07

    Radiomics is an emerging field in quantitative imaging that uses advanced imaging features to objectively and quantitatively describe tumour phenotypes. Radiomic features have recently drawn considerable interest due to its potential predictive power for treatment outcomes and cancer genetics, which may have important applications in personalized medicine. In this technical review, we describe applications and challenges of the radiomic field. We will review radiomic application areas and technical issues, as well as proper practices for the designs of radiomic studies.

  12. Applications and limitations of radiomics

    NASA Astrophysics Data System (ADS)

    Yip, Stephen S. F.; Aerts, Hugo J. W. L.

    2016-07-01

    Radiomics is an emerging field in quantitative imaging that uses advanced imaging features to objectively and quantitatively describe tumour phenotypes. Radiomic features have recently drawn considerable interest due to its potential predictive power for treatment outcomes and cancer genetics, which may have important applications in personalized medicine. In this technical review, we describe applications and challenges of the radiomic field. We will review radiomic application areas and technical issues, as well as proper practices for the designs of radiomic studies.

  13. Applications of Probabilistic Risk Assessment

    SciTech Connect

    Burns, K.J.; Chapman, J.R.; Follen, S.M.; O'Regan, P.J. )

    1991-05-01

    This report provides a summary of potential and actual applications of Probabilistic Risk Assessment (PRA) technology and insights. Individual applications are derived from the experiences of a number of US nuclear utilities. This report identifies numerous applications of PRA techniques beyond those typically associated with PRAs. In addition, believing that the future use of PRA techniques should not be limited to those of the past, areas of plant operations, maintenance, and financial resource allocation are discussed. 9 refs., 3 tabs.

  14. Surgical applications of femtosecond lasers.

    PubMed

    Chung, Samuel H; Mazur, Eric

    2009-10-01

    Femtosecond laser ablation permits non-invasive surgeries in the bulk of a sample with submicrometer resolution. We briefly review the history of optical surgery techniques and the experimental background of femtosecond laser ablation. Next, we present several clinical applications, including dental surgery and eye surgery. We then summarize research applications, encompassing cell and tissue studies, research on C. elegans, and studies in zebrafish. We conclude by discussing future trends of femtosecond laser systems and some possible application directions.

  15. Missions and Means Framework Application

    DTIC Science & Technology

    2005-06-22

    Missions and Means Framework Application 25 Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting...The Missions and Means Framework Application 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e...Prescribed by ANSI Std Z39-18 The Missions and Means Framework Application Presentation to 73rd MORSS U.S. Military Academy 22 June 2005 Paul

  16. Porous microsphere and its applications

    PubMed Central

    Cai, Yunpeng; Chen, Yinghui; Hong, Xiaoyun; Liu, Zhenguo; Yuan, Weien

    2013-01-01

    Porous microspheres have drawn great attention in the last two decades for their potential applications in many fields, such as carriers for drugs, absorption and desorption of substances, pulmonary drug delivery, and tissue regeneration. The application of porous microspheres has become a feasible way to address existing problems. In this essay, we give a brief introduction of the porous microsphere, its characteristics, preparation methods, applications, and a brief summary of existing problems and research tendencies. PMID:23515359

  17. Pulmonary Testing Laboratory Computer Application

    PubMed Central

    Johnson, Martin E.

    1980-01-01

    An interactive computer application reporting patient pulmonary function data has been developed by Washington, D.C. VA Medical Center staff. A permanent on-line data base of patient demographics, lung capacity, flows, diffusion, arterial blood gases and physician interpretation is maintained by a minicomputer at the hospital. A user oriented application program resulted from development in concert with the clinical users. Rapid program development resulted from employing a newly developed time saving technique that has found wide application at other VA Medical Centers. Careful attention to user interaction has resulted in an application program requiring little training and which has been satisfactorily used by a number of clinicians.

  18. Enabling network-aware applications

    SciTech Connect

    Tierney, Brian L.; Gunter, Dan; Lee, Jason; Stouffer, Martin

    2001-08-01

    Many high performance distributed applications use only a small fraction of their available bandwidth. A common cause of this problem is not a flaw in the application design, but rather improperly tuned network settings. Proper tuning techniques, such as setting the correct TCP buffers and using parallel streams, are well known in the networking community, but outside the networking community they are infrequently applied. In this paper, we describe a service that makes the task of network tuning trivial for application developers and users. Widespread use of this service should virtually eliminate a common stumbling block for high performance distributed applications.

  19. Tools for distributed application management

    NASA Technical Reports Server (NTRS)

    Marzullo, Keith; Wood, Mark; Cooper, Robert; Birman, Kenneth P.

    1990-01-01

    Distributed application management consists of monitoring and controlling an application as it executes in a distributed environment. It encompasses such activities as configuration, initialization, performance monitoring, resource scheduling, and failure response. The Meta system is described: a collection of tools for constructing distributed application management software. Meta provides the mechanism, while the programmer specifies the policy for application management. The policy is manifested as a control program which is a soft real time reactive program. The underlying application is instrumented with a variety of built-in and user defined sensors and actuators. These define the interface between the control program and the application. The control program also has access to a database describing the structure of the application and the characteristics of its environment. Some of the more difficult problems for application management occur when pre-existing, nondistributed programs are integrated into a distributed application for which they may not have been intended. Meta allows management functions to be retrofitted to such programs with a minimum of effort.

  20. Tools for distributed application management

    NASA Technical Reports Server (NTRS)

    Marzullo, Keith; Cooper, Robert; Wood, Mark; Birman, Kenneth P.

    1990-01-01

    Distributed application management consists of monitoring and controlling an application as it executes in a distributed environment. It encompasses such activities as configuration, initialization, performance monitoring, resource scheduling, and failure response. The Meta system (a collection of tools for constructing distributed application management software) is described. Meta provides the mechanism, while the programmer specifies the policy for application management. The policy is manifested as a control program which is a soft real-time reactive program. The underlying application is instrumented with a variety of built-in and user-defined sensors and actuators. These define the interface between the control program and the application. The control program also has access to a database describing the structure of the application and the characteristics of its environment. Some of the more difficult problems for application management occur when preexisting, nondistributed programs are integrated into a distributed application for which they may not have been intended. Meta allows management functions to be retrofitted to such programs with a minimum of effort.

  1. 77 FR 8936 - Self-Regulatory Organizations; the NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-15

    ... Effectiveness of Proposed Rule Change To Modify NASDAQ's Pre-Market Investor Program February 10, 2012. Pursuant... of the Proposed Rule Change NASDAQ is proposing to modify its NASDAQ's Pre-Market Investor Program... a Pre-Market Investor Program to encourage greater use of NASDAQ's facilities for trading before...

  2. 24 CFR 232.505 - Application and application fee.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Application and application fee. 232.505 Section 232.505 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT...

  3. Manual control theory and applications. [physiological and neurological applications

    NASA Technical Reports Server (NTRS)

    Sadoff, M.; Repa, B.

    1974-01-01

    Control theory, including manual control theory, and a review of some previous physiological and neurological applications of control theory and associated engineering concepts are reported. The discussion includes a specially tailored battery of critical control tasks that are being developed to monitor astronaut performance in long term orbital flight. The application of these concepts and tasks to patients with various neurological disorders is considered.

  4. Apply Pesticides Correctly, A Guide for Commercial Applicators: Aerial Application.

    ERIC Educational Resources Information Center

    Wamsley, Mary Ann, Ed.; Vermeire, Donna M., Ed.

    This guide contains basic information to meet specific standards for pesticide applicators. The text is concerned with the calibration of dry and liquid pesticide systems for aerial application. Additionally, dispersal equipment is discussed with considerations for environmental and safety factors. (CS)

  5. Nanomaterials for Sensor Applications

    SciTech Connect

    Márquez, Francisco; Morant, Carmen

    2015-01-15

    A large part of the advances in nanotechnology have been directed towards the development of highspeed electronics, more efficient catalysts, and sensors. This latter group of applications has great relevance and unprecedented development potential for the coming years. Some of the main objectives for the development of sensors have focused on making more sensitive, effective and specific sensing devices. The improvement of these systems and the increase of specificity are clearly associated with a decrease in size of the components, which can lead to obtaining more rapid action, almost in real time. Nanomaterials currently used in sensor development include a long list of nanostructured systems, as for example: Metal nanotubes, nanowires, nanofibers, nanocomposites, nanorods, nanoparticles, nanostructured polymers, and different allotropes of carbon as carbon nanotubes, graphene or fullerenes, among others [1]. These nanomaterials are characterized by having unique physicochemical properties, including high electrical and thermal conductivity, extremely high surface area/volume ratio, high mechanical strength and even excellent catalytic properties [1] [2]. These materials, may exhibit relevant physicochemical behavior, such as quantization or electronic confinement effects, which can be used in the development of all kinds of sensors [2]. So far, sensors have been developed for determination and quantification of gases, radiation, biomolecules, microorganisms, etc. [2] [3]. The sensors developed so far usually use the system lock and key, wherein the selective receptor (lock) is selectively anchored to the analyte of interest (or key). This system has great limitations when analyzing the analyte in the presence of other analytes, which can alter the sensitivity or specificity of the measure, as occurs in sensors used in biomedical applications [3] [4]. One possible solution is based on the development of sensor arrays, consisting of a combination of different and

  6. Nanomaterials for Sensor Applications

    DOE PAGES

    Márquez, Francisco; Morant, Carmen

    2015-01-15

    A large part of the advances in nanotechnology have been directed towards the development of highspeed electronics, more efficient catalysts, and sensors. This latter group of applications has great relevance and unprecedented development potential for the coming years. Some of the main objectives for the development of sensors have focused on making more sensitive, effective and specific sensing devices. The improvement of these systems and the increase of specificity are clearly associated with a decrease in size of the components, which can lead to obtaining more rapid action, almost in real time. Nanomaterials currently used in sensor development include amore » long list of nanostructured systems, as for example: Metal nanotubes, nanowires, nanofibers, nanocomposites, nanorods, nanoparticles, nanostructured polymers, and different allotropes of carbon as carbon nanotubes, graphene or fullerenes, among others [1]. These nanomaterials are characterized by having unique physicochemical properties, including high electrical and thermal conductivity, extremely high surface area/volume ratio, high mechanical strength and even excellent catalytic properties [1] [2]. These materials, may exhibit relevant physicochemical behavior, such as quantization or electronic confinement effects, which can be used in the development of all kinds of sensors [2]. So far, sensors have been developed for determination and quantification of gases, radiation, biomolecules, microorganisms, etc. [2] [3]. The sensors developed so far usually use the system lock and key, wherein the selective receptor (lock) is selectively anchored to the analyte of interest (or key). This system has great limitations when analyzing the analyte in the presence of other analytes, which can alter the sensitivity or specificity of the measure, as occurs in sensors used in biomedical applications [3] [4]. One possible solution is based on the development of sensor arrays, consisting of a combination of

  7. Scaling Applications in hydrology

    NASA Astrophysics Data System (ADS)

    Gebremichael, Mekonnen

    2010-05-01

    Besides downscaling applications, scaling properties of hydrological fields can be used to address a variety of research questions. In this presentation, we will use scaling properties to address questions related to satellite evapotranspiration algorithms, precipitation-streamflow relationships, and hydrological model calibration. Most of the existing satellite-based evapotranspiration (ET) algorithms have been developed using fine-resolution Landsat TM and ASTER data. However, these algorithms are often applied to coarse-resolution MODIS data. Our results show that applying the satellite-based algorithms, which are developed at ASTER resolution, to MODIS resolution leads to ET estimates that (1) preserve the overall spatial pattern (spatial correlation in excess of 0.90), (2) increase the spatial standard deviation and maximum value, (3) have modest conditional bias: underestimate low ET rates (< 1 mm/day) and overestimate high ET rates; the overestimation is within 20%. The results emphasize the need for exploring alternatives for estimation of ET from MODIS. Understanding the relationship between the scaling properties of precipitation and streamflow is important in a number of applications. We present the results of a detailed river flow fluctuation analysis on daily records from 14 stations in the Flint River basin in Georgia in the United States with focus on effect of watershed area on long memory of river flow fluctuations. The areas of the watersheds draining to the stations range from 22 km2 to 19,606 km2. Results show that large watersheds have more persistent flow fluctuations and stronger long-term (time greater than scale break point) memory than small watersheds while precipitation time series shows weak long-term correlation. We conclude that a watershed acts as a 'filter' for a 'white noise' precipitation with more significant filtering in case of large watersheds. Finally, we compare the scaling properties of simulated and observed spatial soil

  8. Laser applications in surgery

    PubMed Central

    Azadgoli, Beina

    2016-01-01

    In modern medicine, lasers are increasingly utilized for treatment of a variety of pathologies as interest in less invasive treatment modalities intensifies. The physics behind lasers allows the same basic principles to be applied to a multitude of tissue types using slight modifications of the system. Multiple laser systems have been studied within each field of medicine. The term “laser” was combined with “surgery,” “ablation,” “lithotripsy,” “cancer treatment,” “tumor ablation,” “dermatology,” “skin rejuvenation,” “lipolysis,” “cardiology,” “atrial fibrillation (AF),” and “epilepsy” during separate searches in the PubMed database. Original articles that studied the application of laser energy for these conditions were reviewed and included. A review of laser therapy is presented. Laser energy can be safely and effectively used for lithotripsy, for the treatment of various types of cancer, for a multitude of cosmetic and reconstructive procedures, and for the ablation of abnormal conductive pathways. For each of these conditions, management with lasers is comparable to, and potentially superior to, management with more traditional methods. PMID:28090508

  9. Streamers and their applications

    NASA Astrophysics Data System (ADS)

    Pemen, A. J. M.

    2011-10-01

    In this invited lecture we give an overview of our 15 years of experience on streamer plasma research. Efforts are directed to integrating the competence areas of plasma physics, pulsed power technology and chemical processing. The current status is the development of a large scale pulsed corona system for gas treatment. Applications on biogas conditioning, VOC removal, odor abatement and control of traffic emissions have been demonstrated. Detailed research on electrical and chemical processes resulted in a boost of efficiencies. Energy transfer efficiency to the plasma was raised to above 90%. Simultaneous improvement of the plasma chemistry resulted in a highly efficient radical generation: O-radical production up to 50% of the theoretical maximum has been achieved. A major challenge in pulsed power driven streamers is to unravel, understand and ultimately control the complex interactions between the transient plasma, electrical circuits, and process. Even more a challenge is to yield electron energies that fit activation energies of the process. We will discuss our ideas on adjusting pulsed power waveforms and plasma reactor settings to obtain more controlled catalytic processing: the ``Chemical Transistor'' concept.

  10. Applications of quantum cloning

    NASA Astrophysics Data System (ADS)

    Pomarico, E.; Sanguinetti, B.; Sekatski, P.; Zbinden, H.; Gisin, N.

    2011-10-01

    Quantum Cloning Machines (QCMs) allow for the copying of information, within the limits imposed by quantum mechanics. These devices are particularly interesting in the high-gain regime, i.e., when one input qubit generates a state of many output qubits. In this regime, they allow for the study of certain aspects of the quantum to classical transition. The understanding of these aspects is the root of the two recent applications that we will review in this paper: the first one is the Quantum Cloning Radiometer, a device which is able to produce an absolute measure of spectral radiance. This device exploits the fact that in the quantum regime information can be copied with only finite fidelity, whereas when a state becomes macroscopic, this fidelity gradually increases to 1. Measuring the fidelity of the cloning operation then allows to precisely determine the absolute spectral radiance of the input optical source. We will then discuss whether a Quantum Cloning Machine could be used to produce a state visible by the naked human eye, and the possibility of a Bell Experiment with humans playing the role of detectors.

  11. Applications for Subvocal Speech

    NASA Technical Reports Server (NTRS)

    Jorgensen, Charles; Betts, Bradley

    2007-01-01

    A research and development effort now underway is directed toward the use of subvocal speech for communication in settings in which (1) acoustic noise could interfere excessively with ordinary vocal communication and/or (2) acoustic silence or secrecy of communication is required. By "subvocal speech" is meant sub-audible electromyographic (EMG) signals, associated with speech, that are acquired from the surface of the larynx and lingual areas of the throat. Topics addressed in this effort include recognition of the sub-vocal EMG signals that represent specific original words or phrases; transformation (including encoding and/or enciphering) of the signals into forms that are less vulnerable to distortion, degradation, and/or interception; and reconstruction of the original words or phrases at the receiving end of a communication link. Potential applications include ordinary verbal communications among hazardous- material-cleanup workers in protective suits, workers in noisy environments, divers, and firefighters, and secret communications among law-enforcement officers and military personnel in combat and other confrontational situations.

  12. Nanoplasmonics for photovoltaic applications

    NASA Astrophysics Data System (ADS)

    Mammo, Eliyas D.; Marques-Hueso, Jose; Richards, Bryce S.

    2012-06-01

    Plasmonics has become a focus of recent research in photovoltaic applications primarily due to their effects in enhancing the absorption performance of solar cells. In this paper a review of different approaches that have been proposed to integrate plasmonics technologies into solar cells is presented. It has been observed that a range of metallic nanostructures that show plasmon resonance wavelength in the visible and near-infrared regime can be utilized to increase the coupling of light into the solar cell. This is widely used to increase the coupling of light that can be trapped in thin layers of active regions as in thin film technologies. In this review paper, more attention is given to the techniques of fabricating the metallic nanoparticles and the ways to control their plasmon resonance wavelengths. The role of the shape, size, dielectric permittivity of the host and the type of the metallic nanoparticles on tuning the resonance wavelength are analyzed. Furthermore, the cluster of nanoparticles gives different resonance wavelength from the individual nanoparticles due to dipolar coupling among the nanoparticles. In conclusion, we show how the plasmon resonance can be engineered to increase the absorption performance of conventional solar cells.

  13. Medical applications of nanotechnology.

    PubMed

    Zdrojewicz, Zygmunt; Waracki, Mateusz; Bugaj, Bartosz; Pypno, Damian; Cabała, Krzysztof

    2015-10-29

    Nanotechnologies are new areas of research focusing on affecting matter at the atomic and molecular levels. It is beyond doubt that modern medicine can benefit greatly from it; thus nanomedicine has become one of the main branches of nanotechnological research. Currently it focuses on developing new methods of preventing, diagnosing and treating various diseases. Nanomaterials show very high efficiency in destroying cancer cells and are already undergoing clinical trials. The results are so promising that nanomaterials might become an alternative to traditional cancer therapy, mostly due to the fact that they allow cancer cells to be targeted specifically and enable detailed imaging of tissues, making planning further therapy much easier. Nanoscience might also be a source of the needed breakthrough in the fight against atherosclerosis, since nanostructures may be used in both preventing and increasing the stability of atherosclerotic lesions. One area of interest is creating nanomaterials that are not only efficient, but also well tolerated by the human body. Other potential applications of nanotechnology in medicine include: nanoadjuvants with immunomodulatory properties used to deliver vaccine antigens; the nano-knife, an almost non-invasive method of destroying cancer cells with high voltage electricity; and carbon nanotubes, which are already a popular way of repairing damaged tissues and might be used to regenerate nerves in the future. The aim of this article is to outline the potential uses of nanotechnology in medicine. Original articles and reviews have been used to present the new developments and directions of studies.

  14. Dorsal column stimulator applications

    PubMed Central

    Yampolsky, Claudio; Hem, Santiago; Bendersky, Damián

    2012-01-01

    Background: Spinal cord stimulation (SCS) has been used to treat neuropathic pain since 1967. Following that, technological progress, among other advances, helped SCS become an effective tool to reduce pain. Methods: This article is a non-systematic review of the mechanism of action, indications, results, programming parameters, complications, and cost-effectiveness of SCS. Results: In spite of the existence of several studies that try to prove the mechanism of action of SCS, it still remains unknown. The mechanism of action of SCS would be based on the antidromic activation of the dorsal column fibers, which activate the inhibitory interneurons within the dorsal horn. At present, the indications of SCS are being revised constantly, while new applications are being proposed and researched worldwide. Failed back surgery syndrome (FBSS) is the most common indication for SCS, whereas, the complex regional pain syndrome (CRPS) is the second one. Also, this technique is useful in patients with refractory angina and critical limb ischemia, in whom surgical or endovascular treatment cannot be performed. Further indications may be phantom limb pain, chronic intractable pain located in the head, face, neck, or upper extremities, spinal lumbar stenosis in patients who are not surgical candidates, and others. Conclusion: Spinal cord stimulation is a useful tool for neuromodulation, if an accurate patient selection is carried out prior, which should include a trial period. Undoubtedly, this proper selection and a better knowledge of its underlying mechanisms of action, will allow this cutting edge technique to be more acceptable among pain physicians. PMID:23230533

  15. Applications of chiral symmetry

    SciTech Connect

    Pisarski, R.D.

    1995-03-01

    The author discusses several topics in the applications of chiral symmetry at nonzero temperature. First, where does the rho go? The answer: up. The restoration of chiral symmetry at a temperature T{sub {chi}} implies that the {rho} and a{sub 1} vector mesons are degenerate in mass. In a gauged linear sigma model the {rho} mass increases with temperature, m{sub {rho}}(T{sub {chi}}) > m{sub {rho}}(0). The author conjectures that at T{sub {chi}} the thermal {rho} - a{sub 1}, peak is relatively high, at about {approximately}1 GeV, with a width approximately that at zero temperature (up to standard kinematic factors). The {omega} meson also increases in mass, nearly degenerate with the {rho}, but its width grows dramatically with temperature, increasing to at least {approximately}100 MeV by T{sub {chi}}. The author also stresses how utterly remarkable the principle of vector meson dominance is, when viewed from the modern perspective of the renormalization group. Secondly, he discusses the possible appearance of disoriented chiral condensates from {open_quotes}quenched{close_quotes} heavy ion collisions. It appears difficult to obtain large domains of disoriented chiral condensates in the standard two flavor model. This leads to the last topic, which is the phase diagram for QCD with three flavors, and its proximity to the chiral critical point. QCD may be very near this chiral critical point, and one might thereby generated large domains of disoriented chiral condensates.

  16. Application Process Improvement Yields Results.

    ERIC Educational Resources Information Center

    Holesovsky, Jan Paul

    1995-01-01

    After a continuing effort to improve its grant application process, the department of medical microbiology and immunology at the University of Wisconsin-Madison is submitting many more applications and realizing increased funding. The methods and strategy used to make the process more efficient and effective are outlined. (Author/MSE)

  17. Waiver Applicants Steer Wary Course

    ERIC Educational Resources Information Center

    McNeil, Michele

    2012-01-01

    The latest batch of states seeking relief under the No Child Left Behind Act dodge pitfalls that tripped up the first round of applicants. In the latest round of applications for waivers under the No Child Left Behind Act, states have learned lessons from their predecessors and dodged pitfalls that triggered some big revisions from first-round…

  18. Piezoelectric Transformers for Space Applications

    DTIC Science & Technology

    2003-06-01

    TWTA payload configuration is shown in Figure 3. DC Batteries HIGH VOLTAGE CIRCUITS Collectors Cathode Solar Cells Inverter High Voltage... SOLAR PANNELS SPACE- CRAFT PRIMARY POWER BUS 28 V / 42 V THRUSTER HIGH VOLTAGE POWER SUPPLY CONTROL CIRCUIT IGNITION...to a second group of applications. Worldwide companies are now investigating the use of PTs for power applications, including battery chargers

  19. Information Processing Applications: Curriculum Guidelines.

    ERIC Educational Resources Information Center

    Washington Office of the State Superintendent of Public Instruction, Olympia. Div. of Vocational-Technical and Adult Education Services.

    This guide is intended to serve as a resource for business education instructors who are teaching a course in information processing for the automated office. The following topics are covered: program goals, student learning objectives for production applications, an introduction to production applications, a curriculum outline, student learning…

  20. Clinical application of radiolabelled platelets

    SciTech Connect

    Kessler, C. )

    1990-01-01

    This book presents papers on the clinical applications of radiolabelled platelets. The papers are grouped into six sections on platelet labelling techniques, radiolabelled platelets in cardiology, monitoring of antiplatelet therapy, platelet scintigraphy in stroke patients, platelet scintigraphy in angiology, and platelet scintigraphy in hematology and other clinical applications, including renal transplant rejection.

  1. Applications Development: A Wholistic Approach.

    ERIC Educational Resources Information Center

    Miller, Tobey L.

    1982-01-01

    Louisiana State University applied a wholistic philosophy to its computer applications development. The new standards provide a step-by-step plan for the entire application process, from initiation to implementation and maintenance; list required deliverables instead of rules; and allow the programer and analyst flexibility to exercise technical…

  2. Practical Applications of Space Systems.

    ERIC Educational Resources Information Center

    National Academy of Sciences - National Research Council, Washington, DC. Assembly of Engineering.

    This report gives an overview of a study conducted by the Space Applications Board (SAB) on the practical applications of space systems. In this study, the SAB considered how the nation's space capability might be used to solve problems such as the shortage of food and energy; the improvement of the physical environment; inventorying and…

  3. Polarimetric Interferometry - Remote Sensing Applications

    DTIC Science & Technology

    2007-02-01

    This lecture is mainly based on the work of S.R. Cloude and presents examples for remote sensing applications Polarimetric SAR Interferometry...PolInSAR). PolInSAR has its origins in remote sensing and was first developed for applications in 1997 using SIRC L-Band data [1,2]. In its original form it

  4. User interfaces for voice applications.

    PubMed Central

    Kamm, C

    1995-01-01

    This paper discusses some of the aspects of task requirements, user expectations, and technological capabilities that influence the design of a voice interface and then identifies several components of user interfaces that are particularly critical in successful voice applications. Examples from several applications are provided to demonstrate how these components are used to produce effective voice interfaces. PMID:7479721

  5. User interfaces for voice applications.

    PubMed

    Kamm, C

    1995-10-24

    This paper discusses some of the aspects of task requirements, user expectations, and technological capabilities that influence the design of a voice interface and then identifies several components of user interfaces that are particularly critical in successful voice applications. Examples from several applications are provided to demonstrate how these components are used to produce effective voice interfaces.

  6. User Interfaces for Voice Applications

    NASA Astrophysics Data System (ADS)

    Kamm, Candace

    1995-10-01

    This paper discusses some of the aspects of task requirements, user expectations, and technological capabilities that influence the design of a voice interface and then identifies several components of user interfaces that are particularly critical in successful voice applications. Examples from several applications are provided to demonstrate how these components are used to produce effective voice interfaces.

  7. Microwave applicators for BPH thermotherapy

    NASA Astrophysics Data System (ADS)

    Vrba, Jan; Hlavac, R.; Herza, Jan; Chovanec, Roman; Cvek, Jakub; Oppl, L.

    2004-04-01

    Paper deals with new results in the field of intracavitary microwave applicators used for Benign Prostatic Hyperplasia (BPH) treatment. We demonstrate here that it is necessary to use more sophisticated applicators than a simple monopole radiating structure. One of the good possibilities for safe and efficient treatments we propose here is a helix structure.

  8. Evaluating Application Resilience with XRay

    SciTech Connect

    Chen, Sui; Bronevetsky, Greg; Li, Bin; Casas-Guix, Marc; Peng, Lu

    2015-05-07

    The rising count and shrinking feature size of transistors within modern computers is making them increasingly vulnerable to various types of soft faults. This problem is especially acute in high-performance computing (HPC) systems used for scientific computing, because these systems include many thousands of compute cores and nodes, all of which may be utilized in a single large-scale run. The increasing vulnerability of HPC applications to errors induced by soft faults is motivating extensive work on techniques to make these applications more resiilent to such faults, ranging from generic techniques such as replication or checkpoint/restart to algorithmspecific error detection and tolerance techniques. Effective use of such techniques requires a detailed understanding of how a given application is affected by soft faults to ensure that (i) efforts to improve application resilience are spent in the code regions most vulnerable to faults and (ii) the appropriate resilience technique is applied to each code region. This paper presents XRay, a tool to view the application vulnerability to soft errors, and illustrates how XRay can be used in the context of a representative application. In addition to providing actionable insights into application behavior XRay automatically selects the number of fault injection experiments required to provide an informative view of application behavior, ensuring that the information is statistically well-grounded without performing unnecessary experiments.

  9. Processor Emulator with Benchmark Applications

    SciTech Connect

    Lloyd, G. Scott; Pearce, Roger; Gokhale, Maya

    2015-11-13

    A processor emulator and a suite of benchmark applications have been developed to assist in characterizing the performance of data-centric workloads on current and future computer architectures. Some of the applications have been collected from other open source projects. For more details on the emulator and an example of its usage, see reference [1].

  10. HPRR operating experience and applications

    SciTech Connect

    Bailiff, E.G.; Sims, C.S.; Swaja, R.E.

    1986-01-01

    The Health Physics Research Reactor (HPRR) is a small, unmoderated fast pulse reactor located at the Oak Ridge National Laboratory (ORNL). The HPRR is the principal research tool of ORNL's Dosimetry Applications Research (DOSAR) Group. The reactor is described, its operating experience is presented, and its major applications are discussed.

  11. NAS Applications and Advanced Algorithms

    NASA Technical Reports Server (NTRS)

    Bailey, David H.; Biswas, Rupak; VanDerWijngaart, Rob; Kutler, Paul (Technical Monitor)

    1997-01-01

    This paper examines the applications most commonly run on the supercomputers at the Numerical Aerospace Simulation (NAS) facility. It analyzes the extent to which such applications are fundamentally oriented to vector computers, and whether or not they can be efficiently implemented on hierarchical memory machines, such as systems with cache memories and highly parallel, distributed memory systems.

  12. Automatix Incorporated in aerospace applications

    NASA Astrophysics Data System (ADS)

    Hilmer, C.

    1983-03-01

    Robotic assembly and artificial vision applications are currently employed or have potential in aerospace manufacturing. Automatix vision guided robotics have been used for electronic component assembly, welding of aluminum alloys with both gas metal arc welding (MIG). Other applications include gas tungsten arc welding (TIG), and visual gauging. The unique control concept has provided a single robotic controller with virtual robotic arm interchangeability.

  13. Printing Technologies for Medical Applications.

    PubMed

    Shafiee, Ashkan; Atala, Anthony

    2016-03-01

    Over the past 15 years, printers have been increasingly utilized for biomedical applications in various areas of medicine and tissue engineering. This review discusses the current and future applications of 3D bioprinting. Several 3D printing tools with broad applications from surgical planning to 3D models are being created, such as liver replicas and intermediate splints. Numerous researchers are exploring this technique to pattern cells or fabricate several different tissues and organs, such as blood vessels or cardiac patches. Current investigations in bioprinting applications are yielding further advances. As one of the fastest areas of industry expansion, 3D additive manufacturing will change techniques across biomedical applications, from research and testing models to surgical planning, device manufacturing, and tissue or organ replacement.

  14. Studies on deaf mobile application

    NASA Astrophysics Data System (ADS)

    Nathan, Shelena Soosay; Hussain, Azham; Hashim, Nor Laily

    2016-08-01

    The deaf normally considered to be disabled that do not need any mobile technology due to the inabilities of hearing and talking. However, many deaf are using mobile phone in their daily life for various purposes such as communication and learning. Many studies have attempted to identify the need of deaf people in mobile application and level of usage of the applications. This study aims in studying the recent research conducted on deaf mobile application to understand the level of importance of mobile technology for this disabled community. This paper enable identification of studies conducted are limited and the need of more research done of this disabled people to ensure their privilege of using mobile technology and its application, which leads to the identification of deaf user requirement for mobile application as future study.

  15. Corrugated pipe adhesive applicator apparatus

    DOEpatents

    Shirey, R.A.

    1983-06-14

    Apparatus for coating selected portions of the troughs of a corrugated pipe with an adhesive includes a support disposed within the pipe with a reservoir containing the adhesive disposed on the support. A pump, including a spout, is utilized for supplying the adhesive from the reservoir to a trough of the pipe. A rotatable applicator is supported on the support and contacts the trough of the pipe. The applicator itself is sized so as to fit within the trough, and contacts the adhesive in the trough and spreads the adhesive in the trough upon rotation. A trough shield, supported by the support and disposed in the path of rotation of the applicator, is utilized to prevent the applicator from contacting selected portions of the trough. A locator head is also disposed on the support and provides a way for aligning the spout, the applicator, and the trough shield with the trough. 4 figs.

  16. Steering UNICORE applications with VISIT.

    PubMed

    Eickermann, Thomas; Frings, Wolfgang; Gibbon, Paul; Kirtchakova, Lidia; Mallmann, Daniel; Visser, Anke

    2005-08-15

    The UNICORE (UNiform Interface to COmputing REsources) software provides a Grid infrastructure together with a computing portal for engineers and scientists to access supercomputer centres from anywhere on the Internet. While UNICORE is primarily designed for the submission and control of batch jobs, it is also feasible to establish an on-line connection between an application and the UNICORE user-client. This opens up the possibility of performing on-line visualization and computational steering of applications under UNICORE control while maintaining the security provided by this system. This contribution describes the design of a steering extension to UNICORE based on the steering toolkit VISIT (VISualization Interface Toolkit). VISIT is a lightweight library that supports bidirectional data exchange between visualizations and parallel applications. As an example application, a parallel simulation of a laser-plasma interaction that can be steered by an AVS/Express application is presented.

  17. Functionalized carbon nanotubes: biomedical applications

    PubMed Central

    Vardharajula, Sandhya; Ali, Sk Z; Tiwari, Pooja M; Eroğlu, Erdal; Vig, Komal; Dennis, Vida A; Singh, Shree R

    2012-01-01

    Carbon nanotubes (CNTs) are emerging as novel nanomaterials for various biomedical applications. CNTs can be used to deliver a variety of therapeutic agents, including biomolecules, to the target disease sites. In addition, their unparalleled optical and electrical properties make them excellent candidates for bioimaging and other biomedical applications. However, the high cytotoxicity of CNTs limits their use in humans and many biological systems. The biocompatibility and low cytotoxicity of CNTs are attributed to size, dose, duration, testing systems, and surface functionalization. The functionalization of CNTs improves their solubility and biocompatibility and alters their cellular interaction pathways, resulting in much-reduced cytotoxic effects. Functionalized CNTs are promising novel materials for a variety of biomedical applications. These potential applications are particularly enhanced by their ability to penetrate biological membranes with relatively low cytotoxicity. This review is directed towards the overview of CNTs and their functionalization for biomedical applications with minimal cytotoxicity. PMID:23091380

  18. Ultrafast fiber lasers: practical applications

    NASA Astrophysics Data System (ADS)

    Pastirk, Igor; Sell, Alexander; Herda, Robert; Brodschelm, Andreas; Zach, Armin

    2015-05-01

    Over past three decades ultrafast lasers have come a long way from the bulky, demanding and very sensitive scientific research projects to widely available commercial products. For the majority of this period the titanium-sapphire-based ultrafast systems were the workhorse for scientific and emerging industrial and biomedical applications. However the complexity and intrinsic bulkiness of solid state lasers have prevented even larger penetration into wider array of practical applications. With emergence of femtosecond fiber lasers, based primarily on Er-doped and Yb-doped fibers that provide compact, inexpensive and dependable fs and ps pulses, new practical applications have become a reality. The overview of current state of the art ultrafast fiber sources, their basic principles and most prominent applications will be presented, including micromachining and biomedical implementations (ophthalmology) on one end of the pulse energy spectrum and 3D lithography and THz applications on the other.

  19. NGI performance for teleradiology applications

    NASA Astrophysics Data System (ADS)

    Mogel, Greg T.; Huang, H. K.; Cao, Fei; Zhou, Zheng; Dey, Partha S.; Gill, Michael J.; Liu, Brent J.

    2002-05-01

    Tele-medical imaging applications require low cost, and high-speed backbone wide area networks (WAN) to carry large amount of imaging data for rapid turn around interpretation. Current low cost commercially WAN is too slow for medical imaging applications, while high speed WAN is too costly. The next generation Internet (NGI) or Internet2 is federal initiatives for the integration of higher speed backbone communication networks (up to 2.4 Gbits/sec) as a means to replace the current inadequate Internet for many applications including medical imaging. This paper describes our preliminary experience of connecting to Internet2 for teleradiology application. A case study is given for the NGI WAN connection between Childrens Hospital Los Angeles and National Library of Medicine. NGI WAN performance for different image modalities, measured in throughput rate and application response time, were obtained and then compared to the T1 WAN connection between Childrens Hospital Los Angeles and Saint John's Health Center Santa Monica.

  20. Functionalized carbon nanotubes: biomedical applications.

    PubMed

    Vardharajula, Sandhya; Ali, Sk Z; Tiwari, Pooja M; Eroğlu, Erdal; Vig, Komal; Dennis, Vida A; Singh, Shree R

    2012-01-01

    Carbon nanotubes (CNTs) are emerging as novel nanomaterials for various biomedical applications. CNTs can be used to deliver a variety of therapeutic agents, including biomolecules, to the target disease sites. In addition, their unparalleled optical and electrical properties make them excellent candidates for bioimaging and other biomedical applications. However, the high cytotoxicity of CNTs limits their use in humans and many biological systems. The biocompatibility and low cytotoxicity of CNTs are attributed to size, dose, duration, testing systems, and surface functionalization. The functionalization of CNTs improves their solubility and biocompatibility and alters their cellular interaction pathways, resulting in much-reduced cytotoxic effects. Functionalized CNTs are promising novel materials for a variety of biomedical applications. These potential applications are particularly enhanced by their ability to penetrate biological membranes with relatively low cytotoxicity. This review is directed towards the overview of CNTs and their functionalization for biomedical applications with minimal cytotoxicity.

  1. Corrugated pipe adhesive applicator apparatus

    DOEpatents

    Shirey, Ray A.

    1983-06-14

    Apparatus for coating selected portions of the troughs of a corrugated pipe within an adhesive includes a support disposed within the pipe with a reservoir containing the adhesive disposed on the support. A pump, including a spout, is utilized for supplying the adhesive from the reservoir to a trough of the pipe. A rotatable applicator is supported on the support and contacts the trough of the pipe. The applicator itself is sized so as to fit within the trough, and contacts the adhesive in the trough and spreads the adhesive in the trough upon rotation. A trough shield, supported by the support and disposed in the path of rotation of the applicator, is utilized to prevent the applicator from contacting selected portions of the trough. A locator head is also disposed on the support and provides a way for aligning the spout, the applicator, and the trough shield with the trough.

  2. Java Application Shell: A Framework for Piecing Together Java Applications

    NASA Technical Reports Server (NTRS)

    Miller, Philip; Powers, Edward I. (Technical Monitor)

    2001-01-01

    This session describes the architecture of Java Application Shell (JAS), a Swing-based framework for developing interactive Java applications. Java Application Shell is being developed by Commerce One, Inc. for NASA Goddard Space Flight Center Code 588. The purpose of JAS is to provide a framework for the development of Java applications, providing features that enable the development process to be more efficient, consistent and flexible. Fundamentally, JAS is based upon an architecture where an application is considered a collection of 'plugins'. In turn, a plug-in is a collection of Swing actions defined using XML and packaged in a jar file. Plug-ins may be local to the host platform or remotely-accessible through HTTP. Local and remote plugins are automatically discovered by JAS upon application startup; plugins may also be loaded dynamically without having to re-start the application. Using Extensible Markup Language (XML) to define actions, as opposed to hardcoding them in application logic, allows easier customization of application-specific operations by separating application logic from presentation. Through XML, a developer defines an action that may appear on any number of menus, toolbars, and buttons. Actions maintain and propagate enable/disable states and specify icons, tool-tips, titles, etc. Furthermore, JAS allows actions to be implemented using various scripting languages through the use of IBM's Bean Scripting Framework. Scripted action implementation is seamless to the end-user. In addition to action implementation, scripts may be used for application and unit-level testing. In the case of application-level testing, JAS has hooks to assist a script in simulating end-user input. JAS also provides property and user preference management, JavaHelp, Undo/Redo, Multi-Document Interface, Single-Document Interface, printing, and logging. Finally, Jini technology has also been included into the framework by means of a Jini services browser and the

  3. Applications of multilayer optics

    NASA Astrophysics Data System (ADS)

    Wang, Zhanshan; Zhu, Jingtao; Mu, Baozhong; Zhang, Zhong; Wang, Fengli; Xu, Jing; Li, Wenbin; Chen, Lingyan

    2010-11-01

    Recent development of multilayer mirror and its applications in extreme ultraviolet (EUV), soft X-ray ranges in China was reviewed in this paper. Three types of multilayer mirrors were developed with special performance for dense plasma diagnostics, EUV astronomical observation. Firstly, dual-periodic W/B 4C multilayer mirror was designed for Kirkpatrick-Baez (K-B) microscopy working at TiKα line (4.75 keV), which is highly reflective both at hard X-ray (CuKα line at 8.05 keV) and soft X-ray (4.75 keV). Using this mirror, the K-B system can be aligned conveniently in air using hard X-ray instead of in vacuum. The second mirror is aperiodic Mg/SiC multilayer, also a bi-functional mirror with high reflectivity for He-II emission line (30.4 nm) but suppressing He-I emission line (58.4 nm) in astronomy observation, which will replace the traditional combination of periodic multilayer and the fragile film filter. This will be more safe in satellite launching. The third mirror is Mo/Si periodic multilayer, depositing on a parabolic substrate with diameter of 230 mm, which is designed for EUV telescope for imaging of solar corona by selecting Fe-XII emission (19.5 nm). The uniformity of lateral layer thickness distribution is within ±0.3% along the diameter of mirror, measured by X-ray reflectometry. The measured peak reflectivity is 42% at the wavelength of 19.5 nm. All these multilayer mirrors were prepared by using magnetron sputtering system in our group.

  4. Security Data Warehouse Application

    NASA Technical Reports Server (NTRS)

    Vernon, Lynn R.; Hennan, Robert; Ortiz, Chris; Gonzalez, Steve; Roane, John

    2012-01-01

    The Security Data Warehouse (SDW) is used to aggregate and correlate all JSC IT security data. This includes IT asset inventory such as operating systems and patch levels, users, user logins, remote access dial-in and VPN, and vulnerability tracking and reporting. The correlation of this data allows for an integrated understanding of current security issues and systems by providing this data in a format that associates it to an individual host. The cornerstone of the SDW is its unique host-mapping algorithm that has undergone extensive field tests, and provides a high degree of accuracy. The algorithm comprises two parts. The first part employs fuzzy logic to derive a best-guess host assignment using incomplete sensor data. The second part is logic to identify and correct errors in the database, based on subsequent, more complete data. Host records are automatically split or merged, as appropriate. The process had to be refined and thoroughly tested before the SDW deployment was feasible. Complexity was increased by adding the dimension of time. The SDW correlates all data with its relationship to time. This lends support to forensic investigations, audits, and overall situational awareness. Another important feature of the SDW architecture is that all of the underlying complexities of the data model and host-mapping algorithm are encapsulated in an easy-to-use and understandable Perl language Application Programming Interface (API). This allows the SDW to be quickly augmented with additional sensors using minimal coding and testing. It also supports rapid generation of ad hoc reports and integration with other information systems.

  5. Nanotechnology: Principles and Applications

    NASA Astrophysics Data System (ADS)

    Logothetidis, S.

    Nanotechnology is one of the leading scientific fields today since it combines knowledge from the fields of Physics, Chemistry, Biology, Medicine, Informatics, and Engineering. It is an emerging technological field with great potential to lead in great breakthroughs that can be applied in real life. Novel nano- and biomaterials, and nanodevices are fabricated and controlled by nanotechnology tools and techniques, which investigate and tune the properties, responses, and functions of living and non-living matter, at sizes below 100 nm. The application and use of nanomaterials in electronic and mechanical devices, in optical and magnetic components, quantum computing, tissue engineering, and other biotechnologies, with smallest features, widths well below 100 nm, are the economically most important parts of the nanotechnology nowadays and presumably in the near future. The number of nanoproducts is rapidly growing since more and more nanoengineered materials are reaching the global market The continuous revolution in nanotechnology will result in the fabrication of nanomaterials with properties and functionalities which are going to have positive changes in the lives of our citizens, be it in health, environment, electronics or any other field. In the energy generation challenge where the conventional fuel resources cannot remain the dominant energy source, taking into account the increasing consumption demand and the CO2 emissions alternative renewable energy sources based on new technologies have to be promoted. Innovative solar cell technologies that utilize nanostructured materials and composite systems such as organic photovoltaics offer great technological potential due to their attractive properties such as the potential of large-scale and low-cost roll-to-roll manufacturing processes The advances in nanomaterials necessitate parallel progress of the nanometrology tools and techniques to characterize and manipulate nanostructures. Revolutionary new approaches

  6. Transform coding for space applications

    NASA Technical Reports Server (NTRS)

    Glover, Daniel

    1993-01-01

    Data compression coding requirements for aerospace applications differ somewhat from the compression requirements for entertainment systems. On the one hand, entertainment applications are bit rate driven with the goal of getting the best quality possible with a given bandwidth. Science applications are quality driven with the goal of getting the lowest bit rate for a given level of reconstruction quality. In the past, the required quality level has been nothing less than perfect allowing only the use of lossless compression methods (if that). With the advent of better, faster, cheaper missions, an opportunity has arisen for lossy data compression methods to find a use in science applications as requirements for perfect quality reconstruction runs into cost constraints. This paper presents a review of the data compression problem from the space application perspective. Transform coding techniques are described and some simple, integer transforms are presented. The application of these transforms to space-based data compression problems is discussed. Integer transforms have an advantage over conventional transforms in computational complexity. Space applications are different from broadcast or entertainment in that it is desirable to have a simple encoder (in space) and tolerate a more complicated decoder (on the ground) rather than vice versa. Energy compaction with new transforms are compared with the Walsh-Hadamard (WHT), Discrete Cosine (DCT), and Integer Cosine (ICT) transforms.

  7. 42 CFR 435.907 - Written application.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 4 2012-10-01 2012-10-01 false Written application. 435.907 Section 435.907 Public..., AND AMERICAN SAMOA Eligibility in the States and District of Columbia Applications § 435.907 Written application. (a) The agency must require a written application from the applicant, an...

  8. 42 CFR 435.907 - Written application.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Written application. 435.907 Section 435.907 Public..., AND AMERICAN SAMOA Eligibility in the States and District of Columbia Applications § 435.907 Written application. (a) The agency must require a written application from the applicant, an...

  9. 42 CFR 435.907 - Written application.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false Written application. 435.907 Section 435.907 Public..., AND AMERICAN SAMOA Eligibility in the States and District of Columbia Applications § 435.907 Written application. (a) The agency must require a written application from the applicant, an...

  10. 75 FR 23227 - Initial Patent Applications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-03

    ... renewal. Previously, the utility, design, and plant applications were broken out in a manner that helped... New Plant 7 hours and 36 minutes 350 2,660 Applications--Application Data Sheet. Original New Design 5... Divisional Applications. Plant Continuation/Divisional 2 hours and 12 minutes 150 330 Applications....

  11. 33 CFR 125.21 - Applications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... oath in writing and shall include applicant's answers in full to inquiries with respect to such matters... application also shall include applicant's complete identification, citizenship record, personal description, military record, if any, and a statement of the applicant's sponsor certifying the applicant's...

  12. Alginate: properties and biomedical applications

    PubMed Central

    Lee, Kuen Yong; Mooney, David J.

    2011-01-01

    Alginate is a biomaterial that has found numerous applications in biomedical science and engineering due to its favorable properties, including biocompatibility and ease of gelation. Alginate hydrogels have been particularly attractive in wound healing, drug delivery, and tissue engineering applications to date, as these gels retain structural similarity to the extracellular matrices in tissues and can be manipulated to play several critical roles. This review will provide a comprehensive overview of general properties of alginate and its hydrogels, their biomedical applications, and suggest new perspectives for future studies with these polymers. PMID:22125349

  13. ELECTRICAL TECHNIQUES FOR ENGINEERING APPLICATIONS.

    USGS Publications Warehouse

    Bisdorf, Robert J.

    1985-01-01

    Surface electrical geophysical methods have been used in such engineering applications as locating and delineating shallow gravel deposits, depth to bedrock, faults, clay zones, and other geological phenomena. Other engineering applications include determining water quality, tracing ground water contaminant plumes and locating dam seepages. Various methods and electrode arrays are employed to solve particular geological problems. The sensitivity of a particular method or electrode array depends upon the physics on which the method is based, the array geometry, the electrical contrast between the target and host materials, and the depth to the target. Each of the available electrical methods has its own particular advantages and applications which the paper discusses.

  14. Visualizing Twenty Years of Applications

    SciTech Connect

    Potel, Mike; Wong, Pak C.

    2014-11-01

    This issue of IEEE Computer Graphics and Applications marks the 20th anniversary of the Applications department as a regular feature of the magazine. We thought it might be interesting to look back at the 20 years of Applications department articles to assess its evolution over that time. By aggregating all twenty years of articles and applying a little statistical and visual analytics, we’ve uncovered some interesting characteristics and trends we thought we’d share to mark this 20 year milestone.

  15. Bistable Mechanisms for Space Applications.

    PubMed

    Zirbel, Shannon A; Tolman, Kyler A; Trease, Brian P; Howell, Larry L

    2016-01-01

    Compliant bistable mechanisms are monolithic devices with two stable equilibrium positions separated by an unstable equilibrium position. They show promise in space applications as nonexplosive release mechanisms in deployment systems, thereby eliminating friction and improving the reliability and precision of those mechanical devices. This paper presents both analytical and numerical models that are used to predict bistable behavior and can be used to create bistable mechanisms in materials not previously feasible for compliant mechanisms. Materials compatible with space applications are evaluated for use as bistable mechanisms and prototypes are fabricated in three different materials. Pin-puller and cutter release mechanisms are proposed as potential space applications.

  16. NASA Applications of Molecular Nanotechnology

    NASA Technical Reports Server (NTRS)

    Globus, Al; Bailey, David; Han, Jie; Jaffe, Richard; Levit, Creon; Merkle, Ralph; Srivastava, Deepak

    1998-01-01

    Laboratories throughout the world are rapidly gaining atomically precise control over matter. As this control extends to an ever wider variety of materials, processes and devices, opportunities for applications relevant to NASA's missions will be created. This document surveys a number of future molecular nanotechnology capabilities of aerospace interest. Computer applications, launch vehicle improvements, and active materials appear to be of particular interest. We also list a number of applications for each of NASA's enterprises. If advanced molecular nanotechnology can be developed, almost all of NASA's endeavors will be radically improved. In particular, a sufficiently advanced molecular nanotechnology can arguably bring large scale space colonization within our grasp.

  17. Application specific serial arithmetic arrays

    NASA Technical Reports Server (NTRS)

    Winters, K.; Mathews, D.; Thompson, T.

    1990-01-01

    High performance systolic arrays of serial-parallel multiplier elements may be rapidly constructed for specific applications by applying hardware description language techniques to a library of full-custom CMOS building blocks. Single clock pre-charged circuits have been implemented for these arrays at clock rates in excess of 100 Mhz using economical 2-micron (minimum feature size) CMOS processes, which may be quickly configured for a variety of applications. A number of application-specific arrays are presented, including a 2-D convolver for image processing, an integer polynomial solver, and a finite-field polynomial solver.

  18. Industrial Application Of Instant Holography

    NASA Astrophysics Data System (ADS)

    Schorner, J.; Rottenkolber, H.

    1983-10-01

    The development of holographic test methods has lead to a wide industrial application. Today serial tests of aircraft tyres with holography have become routine. A large chemical company is testing their plastic materials like tanks, wheels and fans with the method of holographic interferometry. In the power engine industry turbine blades are tested holographically to find an optimal shape and to test the vibration behaviour. The automotive industry is using holographic methods' for construction optimization. The economic application of these test methods was possible by using instant holography. The principle of a new hologramrecorder is presented. The application of this equipment is shown in examples of testing materials, optimizing constructions and vibration analysis.

  19. Nanomaterials for Space Exploration Applications

    NASA Technical Reports Server (NTRS)

    Moloney, Padraig G.

    2006-01-01

    Nano-engineered materials are multi-functional materials with superior mechanical, thermal and electrical properties. Nanomaterials may be used for a variety of space exploration applications, including ultracapacitors, active/passive thermal management materials, and nanofiltration for water recovery. Additional applications include electrical power/energy storage systems, hybrid systems power generation, advanced proton exchange membrane fuel cells, and air revitalization. The need for nanomaterials and their growth, characterization, processing and space exploration applications is discussed. Data is presented for developing solid-supported amine adsorbents based on carbon nanotube materials and functionalization of nanomaterials is examined.

  20. Austempered Materials for Powertrain Applications

    NASA Astrophysics Data System (ADS)

    Lefevre, Justin; Hayrynen, Kathy L.

    2013-07-01

    Austempered irons and steels offer the design engineer alternatives to conventional material/process combinations. Depending on the material and the application, Austempering may provide the following benefits to producers of powertrain components such as gears and shafts: ease of manufacturing, increased bending and/or contact fatigue strength, better wear resistance and enhanced dampening characteristics resulting in lower noise. Austempered materials have been used to improve the performance of powertrain components in numerous applications for a wide range of industries, from gears and shafts to clutch plates and crankshafts. This paper focuses on Austempered solutions for powertrain applications with an emphasis on gear and shaft solutions.

  1. Bistable Mechanisms for Space Applications

    PubMed Central

    Zirbel, Shannon A.; Tolman, Kyler A.; Trease, Brian P.

    2016-01-01

    Compliant bistable mechanisms are monolithic devices with two stable equilibrium positions separated by an unstable equilibrium position. They show promise in space applications as nonexplosive release mechanisms in deployment systems, thereby eliminating friction and improving the reliability and precision of those mechanical devices. This paper presents both analytical and numerical models that are used to predict bistable behavior and can be used to create bistable mechanisms in materials not previously feasible for compliant mechanisms. Materials compatible with space applications are evaluated for use as bistable mechanisms and prototypes are fabricated in three different materials. Pin-puller and cutter release mechanisms are proposed as potential space applications. PMID:28030588

  2. Ultrasonics: Fundamentals, Technologies, and Applications

    SciTech Connect

    Ensminger, Dale; Bond, Leonard J.

    2011-09-17

    This is a new edition of a bestselling industry reference. Discusses the science, technology, and applications of low and high power ultrasonics, including industrial implementations and medical uses. Reviews the basic equations of acoustics, starting from basic wave equations and their applications. New material on property determination, inspection of metals (NDT) and non-metals, imaging, process monitoring and control. Expanded discussion of transducers, transducer wave-fields, scattering, attenuation and measurement systems and models. New material that discusses high power ultrasonics - in particular using mechanical effects and sonochemistry, including applications to nano-materials. Examines diagnosis, therapy, and surgery from a technology and medical physics perspective.

  3. User clustering in smartphone applications.

    PubMed

    Schaefers, Klaus; Ribeiro, David

    2012-01-01

    In the context of mobile health applications usability is a crucial factor to achieve user acceptance. The successful user interface (UI) design requires a deep understanding of the needs and requirements of the targeted audience. This paper explores the application of the K-Means algorithm on smartphone usage data in order to offer Human Computer Interaction (HCI) specialists a better insight into their user group. Two different feature space representations are introduced and used to identify persona like stereotypes in a real world data set, which was obtained from a public available smartphone application.

  4. Application of Smart Solid State Sensor Technology in Aerospace Applications

    NASA Technical Reports Server (NTRS)

    Hunter, Gary W.; Xu, Jennifer C.; Dungan, L.K.; Makel, D.; Ward, B.; Androjna, D.

    2008-01-01

    Aerospace applications require a range of chemical sensing technologies to monitor conditions in both space vehicles and aircraft operations. One example is the monitoring of oxygen. For example, monitoring of ambient oxygen (O2) levels is critical to ensuring the health, safety, and performance of humans living and working in space. Oxygen sensors can also be incorporated in detection systems to determine if hazardous leaks are occurring in space propulsion systems and storage facilities. In aeronautic applications, O2 detection has been investigated for fuel tank monitoring. However, as noted elsewhere, O2 is not the only species of interest in aerospace applications with a wide range of species of interest being relevant to understand an environmental or vehicle condition. These include combustion products such as CO, HF, HCN, and HCl, which are related to both the presence of a fire and monitoring of post-fire clean-up operations. This paper discusses the development of an electrochemical cell platform based on a polymer electrolyte, NAFION, and a three-electrode configuration. The approach has been to mature this basic platform for a range of applications and to test this system, combined with "Lick and Stick" electronics, for its viability to monitor an environment related to astronaut crew health and safety applications with an understanding that a broad range of applications can be addressed with a core technology.

  5. 21 CFR 314.65 - Withdrawal by the applicant of an unapproved application.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... SERVICES (CONTINUED) DRUGS FOR HUMAN USE APPLICATIONS FOR FDA APPROVAL TO MARKET A NEW DRUG Applications... application and will provide a copy to the applicant on request under the fee schedule in § 20.45 of...

  6. Terahertz applications: trends and challenges

    NASA Astrophysics Data System (ADS)

    Robin, Thierry; Bouye, Clementine; Cochard, Jacques

    2014-03-01

    The objective of our work [1] was to determine the opportunities and challenges for Terahertz application development for the next years with a focus on systems: for homeland security and for Non Destructive Testing (NDT). Terahertz radiation has unique abilities and has been the subject of extensive research for many years. Proven concepts have emerged for numerous applications including Industrial NDT, Security, Health, Telecommunications, etc. Nevertheless, there has been no widely deployed application and Businesses based on THz technologies are still in their infancy. Some technological, market and industrial barriers are still to be broken. We summarize the final analysis and data: study of the technology trends and major bottlenecks per application segment, main challenges to be addressed in the next years, key opportunities for THz technologies based on market needs and requirements.

  7. Three new applicators for hyperthermia.

    PubMed

    Gabriele, P; Orecchia, R; Tseroni, V; Melano, A; Fillini, C; Ragona, R; Bolla, L; Ogno, G

    1989-01-01

    A computerized system with automatic treatment parameters control for radiological hyperthermia, called Sapic SV03, is presented. The system has been planned and built by the "Sezione Avionica ed Equipaggiamenti" of the Aeritalia in cooperation with the Radiotherapy Department of the University of Turin. The device is supplied with a multifrequency generator system (915, 433, 2-30 MHz) connected with many kinds of applicators, with a fiber optic system for temperature control and a previsional thermometry system. In this paper the authors presented three new applicators. The first one is a concave parallel microstrip applicator at 433 MHz, with a size 16 x 9 cm; the heating pattern is homogenous until 4 cm of depth. This antenna can be used for the treatment of chest wall recurrences of breast cancer. The second is a 27 MHz inductive ring and the third applicator is a pyramidal antenna ("TEM line") that operates at a frequency around 27 MHz.

  8. MICROWAVE TECHNOLOGY CHEMICAL SYNTHESIS APPLICATIONS

    EPA Science Inventory

    Microwave-accelerated chemical syntheses in various solvents as well as under solvent-free conditions have witnessed an explosive growth. The technique has found widespread application predominantly exploiting the inexpensive unmodified household microwave (MW) ovens although th...

  9. Medical Applications of Laser Spectroscopy

    NASA Astrophysics Data System (ADS)

    Svanberg, S.

    1989-01-01

    Lasers are finding many applications in medicine and biology. While most laser use focuses on the heat generation of the laser beam interacting with tissue, spectroscopic aspects play a more dominating part in a number of emerging applications. Tumour-seeking agents, such as hematoporphyrin derivative (HPD), in combination with laser radiation provide new possibilities for cancer tumour detection and treatment. The fluorescence emission from tissue irradiated with UV light can be used for tumour localization. Natural tissue fluorescence as well as fluorescence due to injected HPD can be utilized. Results from studies on animals and from clinical applications are reported. The use of fluorescence for identifying atherosclerotic plaque in human vessels is illustrated. Spectroscopic analysis of the laser-induced plasma obtained when a high-power, pulsed laser beam interacts with tissue is also discussed with applications to plaque removal and laser fragmentation of kidney- and gall-stones.

  10. Pesticide formulations and application systems

    SciTech Connect

    Kaneko; Spicer

    1985-01-01

    This book discusses pesticide formulations; spraying techniques and/or low and ultra low volume applications employing oil carriers, including subsurface drip irrigation and plant growth regulators; and granule technology.

  11. CORRECTIVE ACTIONS- TECHNOLOGIES AND APPLICATIONS

    EPA Science Inventory

    This publication provides information presented at a seminar series designed to address selection and application of technologies suitable for controlling and treating releases of hazardous wastes or their constituents from RCRA treatment, storage and disposal facilities. ngineer...

  12. Trends in Mobile Application Development

    NASA Astrophysics Data System (ADS)

    Holzer, Adrian; Ondrus, Jan

    Major software companies, such as Apple and Google, are disturbing the relatively safe and established actors of the mobile application business. These newcomers have caused significant structural changes by imposing and enforcing their own rules for the future of mobile application development. The implications of these changes do not only concern the mobile network operators and mobile phone manufacturers. This changed environment also brings additional opportunities and constraints for current mobile application developers. Therefore, developers need to assess what their options are and how they can take advantages of these current trends. In this paper, we take a developer’s perspective in order to explore how the structural changes will influence the mobile application development markets. Moreover, we discuss what aspects developers need to take into account in order to position themselves within the current trends.

  13. Nanosized microporous crystals: emerging applications.

    PubMed

    Mintova, Svetlana; Jaber, Maguy; Valtchev, Valentin

    2015-10-21

    This review highlights recent developments in the synthesis and unconventional applications of nanosized microporous crystals including framework (zeolites) and layered (clays) type materials. Owing to their microporous nature nanosized zeolites and clays exhibit novel properties, different from those of bulk materials. The factors controlling the formation of nanosized microporous crystals are first revised. The most promising approaches from the viewpoint of large-scale production of nanosized zeolites and clays are discussed in depth. The preparation and advanced applications of nanosized zeolites and clays in free (suspension and powder forms) and fixed (films) forms are summarized. Further the review emphasises the non-conventional applications of new porous materials. A comprehensive analysis of the emerging applications of microporous nanosized crystals in the field of semiconductor industry, optical materials, chemical sensors, medicine, cosmetics, and food industry is presented. Finally, the future needs and perspectives of nanosized microporous materials (zeolites and clays) are addressed.

  14. Accelarators, Colliders and Their Application

    NASA Astrophysics Data System (ADS)

    Wilson, E.

    This document is part of Subvolume C 'Accelerators and Colliders' of Volume 21 'Elementary Particles' of Landolt-Börnstein - Group I 'Elementary Particles, Nuclei and Atoms'. It contains the Chapter '1 Accelarators, Colliders and Their Application' with the content:

  15. US Navy lithium cell applications

    NASA Technical Reports Server (NTRS)

    Bowers, F. M.

    1978-01-01

    Applications of lithium systems that are already in the fleet are discussed. The approach that the Navy is taking in the control of the introduction of lithium batteries into the fleet is also discussed.

  16. 78 FR 59422 - Delayed Applications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-26

    ... Pipeline and Hazardous Materials Safety Administration Delayed Applications AGENCY: Office of Hazardous Materials Safety, Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: List of... Paquet, Director, Office of Hazardous Materials Special Permits and Approvals, Pipeline and...

  17. Commercial Applications Multispectral Sensor System

    NASA Technical Reports Server (NTRS)

    Birk, Ronald J.; Spiering, Bruce

    1993-01-01

    NASA's Office of Commercial Programs is funding a multispectral sensor system to be used in the development of remote sensing applications. The Airborne Terrestrial Applications Sensor (ATLAS) is designed to provide versatility in acquiring spectral and spatial information. The ATLAS system will be a test bed for the development of specifications for airborne and spaceborne remote sensing instrumentation for dedicated applications. This objective requires spectral coverage from the visible through thermal infrared wavelengths, variable spatial resolution from 2-25 meters; high geometric and geo-location accuracy; on-board radiometric calibration; digital recording; and optimized performance for minimized cost, size, and weight. ATLAS is scheduled to be available in 3rd quarter 1992 for acquisition of data for applications such as environmental monitoring, facilities management, geographic information systems data base development, and mineral exploration.

  18. Geant4 Applications in Space

    SciTech Connect

    Asai, M.; /SLAC

    2007-11-07

    Use of Geant4 is rapidly expanding in space application domain. I try to overview three major application areas of Geant4 in space, which are apparatus simulation for pre-launch design and post-launch analysis, planetary scale simulation for radiation spectra and surface and sub-surface explorations, and micro-dosimetry simulation for single event study and radiation-hardening of semiconductor devices. Recently, not only the mission dependent applications but also various multi-purpose or common tools built on top of Geant4 are also widely available. I overview some of such tools as well. The Geant4 Collaboration identifies that the space applications are now one of the major driving forces of the further developments and refinements of Geant4 toolkit. Highlights of such developments are introduced.

  19. Pediatric cardiovascular safety: challenges in drug and device development and clinical application.

    PubMed

    Bates, Katherine E; Vetter, Victoria L; Li, Jennifer S; Cummins, Susan; Aguel, Fernando; Almond, Christopher; Dubin, Anne M; Elia, Josephine; Finkle, John; Hausner, Elizabeth A; Joseph, Francesca; Karkowsky, Abraham M; Killeen, Matthew; Lemacks, Jodi; Mathis, Lisa; McMahon, Ann W; Pinnow, Ellen; Rodriguez, Ignacio; Stockbridge, Norman L; Stockwell, Margaret; Tassinari, Melissa; Krucoff, Mitchell W

    2012-10-01

    Development of pediatric medications and devices is complicated by differences in pediatric physiology and pathophysiology (both compared with adults and within the pediatric age range), small patient populations, and practical and ethical challenges to designing clinical trials. This article summarizes the discussions that occurred at a Cardiac Safety Research Consortium-sponsored Think Tank convened on December 10, 2010, where members from academia, industry, and regulatory agencies discussed important issues regarding pediatric cardiovascular safety of medications and cardiovascular devices. Pediatric drug and device development may use adult data but often requires additional preclinical and clinical testing to characterize effects on cardiac function and development. Challenges in preclinical trials include identifying appropriate animal models, clinically relevant efficacy end points, and methods to monitor cardiovascular safety. Pediatric clinical trials have different ethical concerns from adult trials, including consideration of the subjects' families. Clinical trial design in pediatrics should assess risks and benefits as well as incorporate input from families. Postmarketing surveillance, mandated by federal law, plays an important role in both drug and device safety assessment and becomes crucial in the pediatric population because of the limitations of premarketing pediatric studies. Solutions for this wide array of issues will require collaboration between academia, industry, and government as well as creativity in pediatric study design. Formation of various epidemiologic tools including registries to describe outcomes of pediatric cardiac disease and its treatment as well as cardiac effects of noncardiovascular medications, should inform preclinical and clinical development and improve benefit-risk assessments for the patients. The discussions in this article summarize areas of emerging consensus and other areas in which consensus remains elusive

  20. Veterinary School Applicants: Financial Literacy and Behaviors.

    PubMed

    Carr, McKensie M; Greenhill, Lisa M

    2015-01-01

    Each year the Association of American Veterinary Medical Colleges (AAVMC) conducts a survey after the close of the Veterinary Medical College Application Service (VMCAS) application. The survey provides a glimpse into applicant behavior surrounding the veterinary school application process. Additional survey questions probe into applicant financial behaviors, use of financial products and services, and pet ownership. This article examines the 2013 survey data from applicants who successfully completed the application, with a focus on applicant financial literacy and behaviors. Data from the study revealed a disconnect between applicants' perception of their ability to deal with day-to-day finances and their actual financial behaviors, particularly for first-generation college student applicants and applicants who are racially/ethnically underrepresented in veterinary medicine (URVM). Many applicants were not able to accurately report the average veterinary school graduate's student debt level, which suggests the potential need for better education about the costs associated with attending veterinary school.